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Sample records for radiation-induced parametric instabilities

  1. Parametric Instability in Advanced Laser Interferometer Gravitational Wave Detectors

    International Nuclear Information System (INIS)

    Ju, L; Grass, S; Zhao, C; Degallaix, J; Blair, D G

    2006-01-01

    High frequency parametric instabilities in optical cavities are radiation pressure induced interactions between test mass mechanical modes and cavity optical modes. The parametric gain depends on the cavity power and the quality factor of the test mass internal modes (usually in ultrasonic frequency range), as well as the overlap integral for the mechanical and optical modes. In advanced laser interferometers which require high optical power and very low acoustic loss test masses, parametric instabilities could prevent interferometer operation if not suppressed. Here we review the problem of parametric instabilities in advanced detector configurations for different combinations of sapphire and fused silica test masses, and compare three methods for control or suppression of parametric instabilities-thermal tuning, surface damping and active feedback

  2. Parametric plasma surface instabilities with s-polarized radiation

    International Nuclear Information System (INIS)

    Rappaport, H.L.

    1994-01-01

    The authors argue that parametric plasma surface mode excitation is a viable broadband instability mechanism in the microwave regime since the wavelength of incident radiation ca be large compared to plasma ion density gradient scale lengths. They restrict their attention to plasmas which are uniform in the planes perpendicular to the density gradients. The boundary is characterized by three parameters: (1) the ion density gradient scale length, (2) the electron Debye length, and (3) the excursion of boundary electrons as they move in response to monochromatic radiation. For s-polarized radiation, equilibrium fluid motion is parallel to the boundary when the ratio of the pump quiver velocity to the speed of light is small. In this case, an abruptly bounded plasma may be modeled with no transition width. If in this case the cold fluid approximation is used as well, the specular and diffuse boundary approximations become the same. A new formation is presented in which pump induced perturbations are expressed as an explicit superposition of linear and non-linear plasma half-space modes. A four-wave interaction is found to produce instability as well as surface wave frequency-shift. This mode is compared against other modes known to exist in this geometry. The theory of surface wave linear mode conversion is reviewed with special attention paid to power flow and energy conservation in this system

  3. Saturation of radiation-induced parametric instabilities by excitation of Langmuir turbulence

    Energy Technology Data Exchange (ETDEWEB)

    Dubois, D.F.; Rose, H.A. [Los Alamos National Lab., NM (United States); Russell, D. [Lodestar Research Inc., Boulder, CO (United States)

    1995-12-01

    Progress made in the last few years in the calculation of the saturation spectra of parametric instabilities which involve Langmuir daughter waves will be reviewed. These instabilities include the ion acoustic decay instability, the two plasmon decay instability (TPDI), and stimulated Raman scattering (SRS). In particular I will emphasize spectral signatures which can be directly compared with experiment. The calculations are based on reduced models of driven Laugmuir turbulence. Thomson scattering from hf-induced Langmuir turbulence in the unpreconditioned ionosphere has resulted in detailed agreement between theory and experiment at early times. Strong turbulence signatures dominate in this regime where the weak turbulence approximation fails completely. Recent experimental studies of the TPDI have measured the Fourier spectra of Langmuir waves as well as the angular and frequency, spectra of light emitted near 3/2 of the pump frequency again permitting some detailed comparisons with theory. The experiments on SRS are less detailed but by Thomson scattering the secondary decay of the daughter Langmuir wave has been observed. Scaling laws derived from a local model of SRS saturation are compared with full simulations and recent Nova experiments.

  4. Saturation of radiation-induced parametric instabilities by excitation of Langmuir turbulence

    International Nuclear Information System (INIS)

    DuBois, D.F.

    1996-01-01

    Progress made in the last few years in the calculation of the saturation spectra of parametric instabilities which involve Langmuir daughter waves will be reviewed. These instabilities include the ion acoustic decay instability, the two plasmon decay instability (TPDI), and stimulated Raman scattering (SRS). In particular we will emphasize spectral signatures which can be directly compared with experiment. The calculations are based on reduced models of driven Langmuir turbulence. Thomson scattering from hf-induced Langmuir turbulence in the unpreconditioned ionosphere has resulted in detailed agreement between theory and experiment at early times. Strong turbulence signatures dominate in this regime where the weak turbulence approximation fails completely. Recent experimental studies of the TPDI have measured the Fourier spectra of Langmuir waves as well as the angular and frequency spectra of light emitted near 3/2 of the pump frequency again permitting some detailed comparisons with theory. Thomson scattering measurements of the Langmuir wave spectra from SRS are consistent with the saturation by secondary and tertiary decay of the primary SRS Langmuir waves. Scaling laws derived from a local model of SRS saturation are compared with full simulations and recent Nova experiments. (orig.)

  5. Radiation-induced instability of human genome

    International Nuclear Information System (INIS)

    Ryabchenko, N.N.; Demina, Eh.A.

    2014-01-01

    A brief review is dedicated to the phenomenon of radiation-induced genomic instability where the increased level of genomic changes in the offspring of irradiated cells is characteristic. Particular attention is paid to the problems of genomic instability induced by the low-dose radiation, role of the bystander effect in formation of radiation-induced instability, and its relationship with individual radiosensitivity. We believe that in accordance with the paradigm of modern radiobiology the increased human individual radiosensitivity can be formed due to the genome instability onset and is a significant risk factor for radiation-induced cancer

  6. Radiation-induced chromosomal instability

    International Nuclear Information System (INIS)

    Ritter, S.

    1999-01-01

    Recent studies on radiation-induced chromosomal instability in the progeny of exposed mammalian cells were briefly described as well as other related studies. For the analysis of chromosomal damage in clones, cells were seeded directly after exposure in cell well-dish to form single cell clones and post-irradiation chromosome aberrations were scored. Both exposure to isoeffective doses of X-ray or 270 MeV/u C-ions (13 keV/μm) increased the number of clones with abnormal karyotype and the increase was similar for X-ray and for C-ions. Meanwhile, in the progeny of cells for mass cultures, there was no indication of a delayed expression of chromosomal damage up to 40 population doublings after the exposure. A high number of aberrant cells were only observed directly after exposure to 10.7 MeV/u O-ions, i.e. in the first cycle cells and decreased with subsequent cell divisions. The reason for these differences in the radiation-induced chromosomal instability between clonal isolates and mass culture has not been clarified. Recent studies indicated that genomic instability occurs at a high frequency in the progeny of cells irradiated with both sparsely and densely ionizing radiation. Such genomic instability is thought likely to increase the risk of carcinogenesis, but more data are required for a well understanding of the health risks resulting from radiation-induced delayed instability. (M.N.)

  7. Parametric instability producing broad symmetrical structure in the spectrum of ionospheric heating-induced radiation

    International Nuclear Information System (INIS)

    Kuo, S.P.

    1997-01-01

    A four-wave interaction process in which an O-mode electromagnetic pump decays parametrically into a lower hybrid decay mode and two-electron Bernstein sidebands is analyzed. It is shown that the instability can be excited in a spatial region near the electron Bernstein/upper hybrid double resonance and in a narrow pump frequency range slightly below the third harmonic electron cyclotron resonance. The two electron Bernstein sidebands have about the same intensity and thus, produce Broad Symmetrical Structure (BSS) in the emission spectrum after being converted into electromagnetic radiation by scattering off background field-aligned density irregularities. The results also show that the size of the instability zone becomes very small as the pump frequency operates near a cyclotron harmonic higher than the third. Thus, the converted emission will be too weak to be detected. This explains why the BSS feature in the spectrum of stimulated electromagnetic emissions (SEEs) has only been observed in the third harmonic case. copyright 1997 American Institute of Physics

  8. Parametric plasma surface instabilities with p-polarized radiation

    International Nuclear Information System (INIS)

    Rappaport, H.L.

    1994-01-01

    The authors argue that parametric plasma surface mode excitation is a viable broadband instability mechanism in the microwave regime since the wavelength of incident radiation can be large compared to plasma ion density gradient scale lengths. The authors restrict their attention to plasmas which are uniform in the planes perpendicular to the density gradients. The boundary region is characterized by three parameters: (1) the ion density gradient length; (2) the electron Debye length; and (3) the excursion of boundary electrons as they move in response to monochromatic p-polarized radiation. A thin vacuum plasma transition layer, in which the ion density gradient scale length is large compared with the Debye length and the electron excursion, is included in the analysis of plasma stability. The recently proposed Lagrangian Frame Two-Plasmon Decay mode (LFTPD) is investigated in the regime in which the instability is not resonantly coupled to surface waves propagating along the boundary region. In this case they have found both spatially dependent growth rate profiles and spatially dependent transit layer magnetic fields due to nonlinear surface currents. LFTPD growth rate profiles are displayed as a function of pump amplitude. The results of a time domain simulation of this mode is also shown

  9. White-light parametric instabilities in plasmas.

    Science.gov (United States)

    Santos, J E; Silva, L O; Bingham, R

    2007-06-08

    Parametric instabilities driven by partially coherent radiation in plasmas are described by a generalized statistical Wigner-Moyal set of equations, formally equivalent to the full wave equation, coupled to the plasma fluid equations. A generalized dispersion relation for stimulated Raman scattering driven by a partially coherent pump field is derived, revealing a growth rate dependence, with the coherence width sigma of the radiation field, scaling with 1/sigma for backscattering (three-wave process), and with 1/sigma1/2 for direct forward scattering (four-wave process). Our results demonstrate the possibility to control the growth rates of these instabilities by properly using broadband pump radiation fields.

  10. Ionizing radiation induced genomic instability and its relation to radiation carcinogenesis

    International Nuclear Information System (INIS)

    Wang Zhongwen

    2000-01-01

    There are widespread testimonies that the genomic instability induced by ionizing irradiation exits in mammal and its vitro cells. Genomic instability can enhance the frequency of genetic changes among the progeny of the original irradiated cells. In the radiation-leukemogenesis, there is no significant difference between controls and CBA/H mouses of PPI (preconception patent irradiation), but the offsprings of the PPI recipients show a different character (shorter latent period and higher incidence) after an extra γ-radiation. The radiation-induced genomic instability may get the genome on the verge of mutation and lead to carcinogens following mutation of some critical genes. The genomic instability, as the early event of initiation of carcinomas, may be play a specific or unique role

  11. Ionospheric modification and parametric instabilities

    International Nuclear Information System (INIS)

    Fejer, J.A.

    1979-01-01

    Thresholds and linear growth rates for stimulated Brillouin and Raman scattering and for the parametric decay instability are derived by using arguments of energy transfer. For this purpose an expression for the ponderomotive force is derived. Conditions under which the partial pressure force due to differential dissipation exceeds the ponderomotive force are also discussed. Stimulated Brillouin and Raman scattering are weakly excited by existing incoherent backscatter radars. The parametric decay instability is strongly excited in ionospheric heating experiments. Saturation theories of the parametric decay instability are therefore described. After a brief discussion of the purely growing instability the effect of using several pumps is discussed as well as the effects of inhomogenicity. Turning to detailed theories of ionospheric heating, artificial spread F is discussed in terms of a purely growing instability where the nonlinearity is due to dissipation. Field-aligned short-scale striations are explained in terms of dissipation of the parametrically excited Langmuir waves (plasma oscillations): they might be further amplified by an explosive instability (except the magnetic equator). Broadband absorption is probably responsible for the 'overshoot' effect: the initially observed level of parametrically excited Langmuir waves is much higher than the steady state level

  12. A general approach to optomechanical parametric instabilities

    International Nuclear Information System (INIS)

    Evans, M.; Barsotti, L.; Fritschel, P.

    2010-01-01

    We present a simple feedback description of parametric instabilities which can be applied to a variety of optical systems. Parametric instabilities are of particular interest to the field of gravitational-wave interferometry where high mechanical quality factors and a large amount of stored optical power have the potential for instability. In our use of Advanced LIGO as an example application, we find that parametric instabilities, if left unaddressed, present a potential threat to the stability of high-power operation.

  13. Relativistic parametric instabilities in extended extragalactic radio sources

    Energy Technology Data Exchange (ETDEWEB)

    Ferrari, A [Consiglio Nazionale delle Ricerche, Turin (Italy). Lab. di Cosmo-Geofisica; Trussoni, E; Zaninetti, L

    1978-01-01

    A general discussion is presented of parametric instabilities of electromagnetic waves in cold plasmas. Previous results for f = eE/msub(e)c..omega../sub 0/ >> 1 and << 1 are extended and the intermediate range f approximately 1, which could be relevant in some astrophysical applications, is analysed by numerical techniques. In the final section a model for particle acceleration and radiation emission by turbulent plasma modes excited in extended radiosources by parametric absorption of strong electromagnetic waves is tentatively discussed.

  14. Absolute decay parametric instability of high-temperature plasma

    International Nuclear Information System (INIS)

    Zozulya, A.A.; Silin, V.P.; Tikhonchuk, V.T.

    1986-01-01

    A new absolute decay parametric instability having wide spatial localization region is shown to be possible near critical plasma density. Its excitation is conditioned by distributed feedback of counter-running Langmuir waves occurring during parametric decay of incident and reflected pumping wave components. In a hot plasma with the temperature of the order of kiloelectronvolt its threshold is lower than that of a known convective decay parametric instability. Minimum absolute instability threshold is shown to be realized under conditions of spatial parametric resonance of higher orders

  15. Parametric influence of powerful radiation on plasma surface

    International Nuclear Information System (INIS)

    Kuklin, V.M.; Panchenko, I.P.; Chernousenko, V.M.

    1989-01-01

    A self-consistent set of equations that describes one-dimensional dynamics to develop the instability of long-wave intensive Langmuir wave is obtained and solved. The parametric instability influence on the character of absorption of the incident radiation energy is elucidated primarily. 40 refs.; 8 figs

  16. Observation of Parametric Instability in Advanced LIGO.

    Science.gov (United States)

    Evans, Matthew; Gras, Slawek; Fritschel, Peter; Miller, John; Barsotti, Lisa; Martynov, Denis; Brooks, Aidan; Coyne, Dennis; Abbott, Rich; Adhikari, Rana X; Arai, Koji; Bork, Rolf; Kells, Bill; Rollins, Jameson; Smith-Lefebvre, Nicolas; Vajente, Gabriele; Yamamoto, Hiroaki; Adams, Carl; Aston, Stuart; Betzweiser, Joseph; Frolov, Valera; Mullavey, Adam; Pele, Arnaud; Romie, Janeen; Thomas, Michael; Thorne, Keith; Dwyer, Sheila; Izumi, Kiwamu; Kawabe, Keita; Sigg, Daniel; Derosa, Ryan; Effler, Anamaria; Kokeyama, Keiko; Ballmer, Stefan; Massinger, Thomas J; Staley, Alexa; Heinze, Matthew; Mueller, Chris; Grote, Hartmut; Ward, Robert; King, Eleanor; Blair, David; Ju, Li; Zhao, Chunnong

    2015-04-24

    Parametric instabilities have long been studied as a potentially limiting effect in high-power interferometric gravitational wave detectors. Until now, however, these instabilities have never been observed in a kilometer-scale interferometer. In this Letter, we describe the first observation of parametric instability in a gravitational wave detector, and the means by which it has been removed as a barrier to progress.

  17. Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review.

    Science.gov (United States)

    Lorimore, S A; Wright, E G

    2003-01-01

    To review studies of radiation responses in the haemopoietic system in the context of radiation-induced genomic instability, bystander effects and inflammatory-type processes. There is considerable evidence that cells that themselves are not exposed to ionizing radiation but are the progeny of cells irradiated many cell divisions previously may express a high frequency of gene mutations, chromosomal aberrations and cell death. These effects are collectively known as radiation-induced genomic instability. A second untargeted effect results in non-irradiated cells exhibiting responses typically associated with direct radiation exposure but occurs as a consequence of contact with irradiated cells or by receiving soluble signals from irradiated cells. These effects are collectively known as radiation-induced bystander effects. Reported effects include increases or decreases in damage-inducible and stress-related proteins; increases or decreases in reactive oxygen species, cell death or cell proliferation, and induction of mutations and chromosome aberrations. This array of responses is reminiscent of effects mediated by cytokines and other similar regulatory factors that may involve, but do not necessarily require, gap junction-mediated transfer, have multiple inducers and a variety of context-dependent consequences in different cell systems. That chromosomal instability in haemopoietic cells can be induced by an indirect bystander-type mechanism both in vitro and in vivo provides a potential link between these two untargeted effects and there are radiation responses in vivo consistent with the microenvironment contributing secondary cell damage as a consequence of an inflammatory-type response to radiation-induced injury. Intercellular signalling, production of cytokines and free radicals are features of inflammatory responses that have the potential for both bystander-mediated and persisting damage as well as for conferring a predisposition to malignancy. The

  18. Genomic instability and radiation

    Energy Technology Data Exchange (ETDEWEB)

    Little, John B [Harvard School of Public Health, Boston, MA 02115 (United States)

    2003-06-01

    Genomic instability is a hallmark of cancer cells, and is thought to be involved in the process of carcinogenesis. Indeed, a number of rare genetic disorders associated with a predisposition to cancer are characterised by genomic instability occurring in somatic cells. Of particular interest is the observation that transmissible instability can be induced in somatic cells from normal individuals by exposure to ionising radiation, leading to a persistent enhancement in the rate at which mutations and chromosomal aberrations arise in the progeny of the irradiated cells after many generations of replication. If such induced instability is involved in radiation carcinogenesis, it would imply that the initial carcinogenic event may not be a rare mutation occurring in a specific gene or set of genes. Rather, radiation may induce a process of instability in many cells in a population, enhancing the rate at which the multiple gene mutations necessary for the development of cancer may arise in a given cell lineage. Furthermore, radiation could act at any stage in the development of cancer by facilitating the accumulation of the remaining genetic events required to produce a fully malignant tumour. The experimental evidence for such induced instability is reviewed. (review)

  19. Genomic instability and radiation

    International Nuclear Information System (INIS)

    Little, John B

    2003-01-01

    Genomic instability is a hallmark of cancer cells, and is thought to be involved in the process of carcinogenesis. Indeed, a number of rare genetic disorders associated with a predisposition to cancer are characterised by genomic instability occurring in somatic cells. Of particular interest is the observation that transmissible instability can be induced in somatic cells from normal individuals by exposure to ionising radiation, leading to a persistent enhancement in the rate at which mutations and chromosomal aberrations arise in the progeny of the irradiated cells after many generations of replication. If such induced instability is involved in radiation carcinogenesis, it would imply that the initial carcinogenic event may not be a rare mutation occurring in a specific gene or set of genes. Rather, radiation may induce a process of instability in many cells in a population, enhancing the rate at which the multiple gene mutations necessary for the development of cancer may arise in a given cell lineage. Furthermore, radiation could act at any stage in the development of cancer by facilitating the accumulation of the remaining genetic events required to produce a fully malignant tumour. The experimental evidence for such induced instability is reviewed. (review)

  20. Trans-generational radiation-induced chromosomal instability in the female enhances the action of chemical mutagens

    International Nuclear Information System (INIS)

    Camats, Nuria; Garcia, Francisca; Parrilla, Juan Jose; Calaf, Joaquim; Martin, Miguel; Caldes, Montserrat Garcia

    2008-01-01

    Genomic instability can be produced by ionising radiation, so-called radiation-induced genomic instability, and chemical mutagens. Radiation-induced genomic instability occurs in both germinal and somatic cells and also in the offspring of irradiated individuals, and it is characterised by genetic changes including chromosomal rearrangements. The majority of studies of trans-generational, radiation-induced genomic instability have been described in the male germ line, whereas the authors who have chosen the female as a model are scarce. The aim of this work is to find out the radiation-induced effects in the foetal offspring of X-ray-treated female rats and, at the same time, the possible impact of this radiation-induced genomic instability on the action of a chemical mutagen. In order to achieve both goals, the quantity and quality of chromosomal damage were analysed. In order to detect trans-generational genomic instability, a total of 4806 metaphases from foetal tissues from the foetal offspring of X-irradiated female rats (5 Gy, acute dose) were analysed. The study's results showed that there is radiation-induced genomic instability: the number of aberrant metaphases and the breaks per total metaphases studied increased and were found to be statistically significant (p ≤ 0.05), with regard to the control group. In order to identify how this trans-generational, radiation-induced chromosomal instability could influence the chromosomal behaviour of the offspring of irradiated rat females in front of a chemical agent (aphidicolin), a total of 2481 metaphases were studied. The observed results showed that there is an enhancement of the action of the chemical agent: chromosomal breaks per aberrant metaphases show significant differences (p ≤ 0.05) in the X-ray- and aphidicolin-treated group as regards the aphidicolin-treated group. In conclusion, our findings indicate that there is trans-generational, radiation-induced chromosomal instability in the foetal cells

  1. Trans-generational radiation-induced chromosomal instability in the female enhances the action of chemical mutagens

    Energy Technology Data Exchange (ETDEWEB)

    Camats, Nuria [Institut de Biotecnologia i Biomedicina (IBB), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Garcia, Francisca [Institut de Biotecnologia i Biomedicina (IBB), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Parrilla, Juan Jose [Servicio de Ginecologia y Obstetricia, Hospital Universitario Virgen de la Arrixaca, 30120 El Palmar, Murcia (Spain); Calaf, Joaquim [Servei de Ginecologia i Obstetricia, Hospital Universitari de la Santa Creu i Sant Pau, 08025 Barcelona (Spain); Martin, Miguel [Departament de Pediatria, d' Obstetricia i Ginecologia i de Medicina Preventiva, Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Caldes, Montserrat Garcia [Institut de Biotecnologia i Biomedicina (IBB), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Departament de Biologia Cel.lular, Fisiologia i Immunologia, Universitat Autonoma de Barcelona, 08193 Barcelona (Spain)], E-mail: Montserrat.Garcia.Caldes@uab.es

    2008-04-02

    Genomic instability can be produced by ionising radiation, so-called radiation-induced genomic instability, and chemical mutagens. Radiation-induced genomic instability occurs in both germinal and somatic cells and also in the offspring of irradiated individuals, and it is characterised by genetic changes including chromosomal rearrangements. The majority of studies of trans-generational, radiation-induced genomic instability have been described in the male germ line, whereas the authors who have chosen the female as a model are scarce. The aim of this work is to find out the radiation-induced effects in the foetal offspring of X-ray-treated female rats and, at the same time, the possible impact of this radiation-induced genomic instability on the action of a chemical mutagen. In order to achieve both goals, the quantity and quality of chromosomal damage were analysed. In order to detect trans-generational genomic instability, a total of 4806 metaphases from foetal tissues from the foetal offspring of X-irradiated female rats (5 Gy, acute dose) were analysed. The study's results showed that there is radiation-induced genomic instability: the number of aberrant metaphases and the breaks per total metaphases studied increased and were found to be statistically significant (p {<=} 0.05), with regard to the control group. In order to identify how this trans-generational, radiation-induced chromosomal instability could influence the chromosomal behaviour of the offspring of irradiated rat females in front of a chemical agent (aphidicolin), a total of 2481 metaphases were studied. The observed results showed that there is an enhancement of the action of the chemical agent: chromosomal breaks per aberrant metaphases show significant differences (p {<=} 0.05) in the X-ray- and aphidicolin-treated group as regards the aphidicolin-treated group. In conclusion, our findings indicate that there is trans-generational, radiation-induced chromosomal instability in the foetal

  2. Interplay between parametric instabilities in fusion - relevant laser plasmas

    International Nuclear Information System (INIS)

    Huller, St.

    2003-01-01

    The control of parametric instabilities plays an important role in laser fusion. They are driven by the incident laser beams in the underdense plasma surrounding a fusion capsule and hinder the absorption process of incident laser light which is necessary to heat the fusion target. Due to its high intensity and power, the laser light modifies the plasma density dynamically, such that two or more parametric instabilities compete, in particular stimulated Brillouin scattering and the filamentation instability. The complicated interplay between these parametric instabilities is studied in detail by developing an adequate model accompanied by numerical simulations with multidimensional codes. The model is applied to generic and to smoothed laser beams, which are necessary to limit parametric instabilities, with parameters close to experimental conditions. (author)

  3. Parametric instabilities in advanced gravitational wave detectors

    International Nuclear Information System (INIS)

    Gras, S; Zhao, C; Blair, D G; Ju, L

    2010-01-01

    As the LIGO interferometric gravitational wave detectors have finished gathering a large observational data set, an intense effort is underway to upgrade these observatories to improve their sensitivity by a factor of ∼10. High circulating power in the arm cavities is required, which leads to the possibility of parametric instability due to three-mode opto-acoustic resonant interactions between the carrier, transverse optical modes and acoustic modes. Here, we present detailed numerical analysis of parametric instability in a configuration that is similar to Advanced LIGO. After examining parametric instability for a single three-mode interaction in detail, we examine instability for the best and worst cases, as determined by the resonance condition of transverse modes in the power and signal recycling cavities. We find that, in the best case, the dual recycling detector is substantially less susceptible to instability than a single cavity, but its susceptibility is dependent on the signal recycling cavity design, and on tuning for narrow band operation. In all cases considered, the interferometer will experience parametric instability at full power operation, but the gain varies from 3 to 1000, and the number of unstable modes varies between 7 and 30 per test mass. The analysis focuses on understanding the detector complexity in relation to opto-acoustic interactions, on providing insights that can enable predictions of the detector response to transient disturbances, and of variations in thermal compensation conditions.

  4. Radiation-induced transgenerational instability.

    Science.gov (United States)

    Dubrova, Yuri E

    2003-10-13

    To date, the analysis of mutation induction has provided an irrefutable evidence for an elevated germline mutation rate in the parents directly exposed to ionizing radiation and a number of chemical mutagens. However, the results of numerous publications suggest that radiation may also have an indirect effect on genome stability, which is transmitted through the germ line of irradiated parents to their offspring. This review describes the phenomenon of transgenerational instability and focuses on the data showing increased cancer incidence and elevated mutation rates in the germ line and somatic tissues of the offspring of irradiated parents. The possible mechanisms of transgenerational instability are also discussed.

  5. Chromosomal instability induced by ionizing radiation

    International Nuclear Information System (INIS)

    Morgan, W.F.; Marder, B.A.; Day, J.P.

    1995-01-01

    There is accumulating evidence indicating genomic instability can manifest multiple generations after cellular exposure to DNA damaging agents. For instance, some cells surviving exposure to ionizing radiations show delayed reproductive cell death, delayed mutation and / or delayed chromosomal instability. Such instability, especially chromosome destabilization has been implicated in mutation, gene amplification, cellular transformation, and cell killing. To investigate chromosomal instability following DNA damage, we have used fluorescence in situ hybridization to detect chromosomal rearrangements in a human/hamster somatic hybrid cell line following exposure to ionizing radiation. Delayed chromosomal instability was detected when multiple populations of uniquely arranged metaphases were observed in clonal isolates raised from single cells. The relationship between delayed chromosomal destabilization and other endpoints of genomic instability, namely; delayed mutation and gene amplification will be discussed, as will the potential cytogenetic and molecular mechanisms contributing to delayed chromosomal instability

  6. Parametrically tunable soliton-induced resonant radiation by three-wave mixing

    DEFF Research Database (Denmark)

    Zhou, Binbin; Liu, Xing; Guo, Hairun

    2017-01-01

    We show that a temporal soliton can induce resonant radiation by three-wave mixing nonlinearities. This constitutes a new class of resonant radiation whose spectral positions are parametrically tunable. The experimental verification is done in a periodically poled lithium niobate crystal, where...... a femtosecond near-IR soliton is excited and resonant radiation waves are observed exactly at the calculated soliton phasematching wavelengths via the sum- and difference-frequency generation nonlinearities. This extends the supercontinuum bandwidth well into the mid IR to span 550–5000 nm, and the mid-IR edge...

  7. Mitigation of radiation-pressure-induced angular instability of a Fabry–Perot cavity consisting of suspended mirrors

    Energy Technology Data Exchange (ETDEWEB)

    Nagano, Koji, E-mail: knagano@icrr.u-tokyo.ac.jp [KAGRA Observatory, Institute for Cosmic Ray Research, The University of Tokyo, 5-1-5 Kashiwa-no-Ha, Kashiwa, Chiba 277-8582 (Japan); Enomoto, Yutaro; Nakano, Masayuki [KAGRA Observatory, Institute for Cosmic Ray Research, The University of Tokyo, 5-1-5 Kashiwa-no-Ha, Kashiwa, Chiba 277-8582 (Japan); Furusawa, Akira [Department of Applied Physics, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656 (Japan); Kawamura, Seiji [KAGRA Observatory, Institute for Cosmic Ray Research, The University of Tokyo, 5-1-5 Kashiwa-no-Ha, Kashiwa, Chiba 277-8582 (Japan)

    2016-12-01

    To observe radiation pressure noise in optical cavities consisting of suspended mirrors, high laser power is necessary. However, because the radiation pressure on the mirrors could cause an angular anti-spring effect, the high laser power could induce angular instability to the cavity. An angular control system using radiation pressure as an actuator, which was previously invented to reduce the anti-spring effect for the low power case, was applied to the higher power case where the angular instability would occur. As a result the angular instability was mitigated. It was also demonstrated that the cavity was unstable without this control system. - Highlights: • High laser power could cause angular instability to a suspended Fabry–Perot cavity. • To mitigate the instability, the control system using radiation pressure is applied. • Mitigating the radiation-pressure-induced angular instability is demonstrated. • It is also confirmed that the cavity would be unstable without the control system.

  8. Parametric instability in GEO 600 interferometer

    International Nuclear Information System (INIS)

    Gurkovsky, A.G.; Vyatchanin, S.P.

    2007-01-01

    We present analysis of undesirable effect of parametric instability in signal recycled GEO 600 interferometer. The basis for this effect is provided by excitation of additional (Stokes) optical mode, having frequency ω 1 , and mirror elastic mode, having frequency ω m , when the optical energy stored in the main FP cavity mode, having frequency ω 0 , exceeds a certain threshold and detuning Δ=ω 0 -ω 1 -ω m is small. We discuss the potential of observing parametric instability and its precursors in GEO 600 interferometer. This approach provides the best option to get familiar with this phenomenon, to develop experimental methods to depress it and to test the effectiveness of these methods in situ

  9. Bystander effects in UV-induced genomic instability: Antioxidants inhibit delayed mutagenesis induced by ultraviolet A and B radiation

    Directory of Open Access Journals (Sweden)

    Dahle Jostein

    2005-01-01

    Full Text Available Abstract Background Genomic instability is characteristic of many types of human cancer. Recently, we reported that ultraviolet radiation induced elevated mutation rates and chromosomal instability for many cell generations after ultraviolet irradiation. The increased mutation rates of unstable cells may allow them to accumulate aberrations that subsequently lead to cancer. Ultraviolet A radiation, which primarily acts by oxidative stress, and ultraviolet B radiation, which initially acts by absorption in DNA and direct damage to DNA, both produced genomically unstable cell clones. In this study, we have determined the effect of antioxidants on induction of delayed mutations by ultraviolet radiation. Delayed mutations are indicative of genomic instability. Methods Delayed mutations in the hypoxanthine phosphoribosyl transferase (hprt gene were detected by incubating the cells in medium selectively killing hprt mutants for 8 days after irradiation, followed by a 5 day period in normal medium before determining mutation frequencies. Results The UVB-induced delayed hprt mutations were strongly inhibited by the antioxidants catalase, reduced glutathione and superoxide dismutase, while only reduced glutathione had a significant effect on UVA-induced delayed mutations. Treatment with antioxidants had only minor effects on early mutation frequenies, except that reduced glutathione decreased the UVB-induced early mutation frequency by 24 %. Incubation with reduced glutathione was shown to significantly increase the intracellular amount of reduced glutathione. Conclusion The strong effects of these antioxidants indicate that genomic instability, which is induced by the fundamentally different ultraviolet A and ultraviolet B radiation, is mediated by reactive oxygen species, including hydrogen peroxide and downstream products. However, cells take up neither catalase nor SOD, while incubation with glutathione resulted in increased intracellular levels of

  10. Electron Parametric Instabilities Driven by Relativistically Intense Laser Light in Plasma

    Science.gov (United States)

    Barr, H. C.; Mason, P.; Parr, D. M.

    1999-08-01

    A unified treatment of electron parametric instabilities driven by ultraintense laser light in plasma is described. It is valid for any intensity, polarization, plasma density, and scattering geometry. The method is applied to linearly polarized light in both underdense plasma and overdense plasma accessible by self-induced transparency. New options arise which are hybrids of stimulated Raman scattering, the two plasmon decay, the relativistic modulational and filamentation instabilities, and stimulated harmonic generation. There is vigorous growth over a wide range of wave numbers and harmonics.

  11. Strategies for the control of parametric instability in advanced gravitational wave detectors

    International Nuclear Information System (INIS)

    Ju, L; Blair, D G; Zhao, C; Gras, S; Zhang, Z; Barriga, P; Miao, H; Fan, Y; Merrill, L

    2009-01-01

    Parametric instabilities have been predicted to occur in all advanced high optical power gravitational wave detectors. In this paper we review the problem of parametric instabilities, summarize the latest findings and assess various schemes proposed for their control. We show that non-resonant passive damping of test masses reduces parametric instability but has a noise penalty, and fails to suppress the Q-factor of many modes. Resonant passive damping is shown to have significant advantages but requires detailed modeling. An optical feedback mode suppression interferometer is proposed which is capable of suppressing all instabilities but requires experimental development.

  12. Strategies for the control of parametric instability in advanced gravitational wave detectors

    Energy Technology Data Exchange (ETDEWEB)

    Ju, L; Blair, D G; Zhao, C; Gras, S; Zhang, Z; Barriga, P; Miao, H; Fan, Y; Merrill, L, E-mail: juli@physics.uwa.edu.a [School of Physics, University of Western Australia, 35 Stirling Highway, Crawley, Perth, WA 6009 (Australia)

    2009-01-07

    Parametric instabilities have been predicted to occur in all advanced high optical power gravitational wave detectors. In this paper we review the problem of parametric instabilities, summarize the latest findings and assess various schemes proposed for their control. We show that non-resonant passive damping of test masses reduces parametric instability but has a noise penalty, and fails to suppress the Q-factor of many modes. Resonant passive damping is shown to have significant advantages but requires detailed modeling. An optical feedback mode suppression interferometer is proposed which is capable of suppressing all instabilities but requires experimental development.

  13. Investigation of Parametric Instability of the Planetary Gear under Speed Fluctuations

    Directory of Open Access Journals (Sweden)

    Xinghui Qiu

    2017-01-01

    Full Text Available Planetary gear is widely used in engineering and usually has symmetrical structure. As the number of teeth in contact changes during rotation, the time-varying mesh stiffness parametrically excites the planetary gear and may cause severe vibrations and instabilities. Taking speed fluctuations into account, the time-varying mesh stiffness is frequency modulated, and therefore sideband instabilities may arise and original instabilities are significantly affected. Considering two different speed fluctuations, original and sideband instabilities are numerically and analytically investigated. A rotational lumped-parameter model of the planetary gear is developed, in which the time-varying mesh stiffness, input speed fluctuations, and damping are considered. Closed-form approximations of instability boundaries for primary and combination instabilities are obtained by perturbation analysis and verified by numerical analysis. The effects of speed fluctuations and damping on parametric instability are systematically examined. Because of the frequency modulation, whether a parametric instability occurs cannot be simply predicted by the planet meshing phase which is applicable to constant speed. Besides adjusting the planet meshing phase, speed fluctuation supplies a new thought to minimize certain instability by adjusting the amplitude or frequency of the speed fluctuation. Both original and sideband instabilities are shrunken by damping, and speed fluctuation further shrinks the original instability.

  14. Parametric instabilities of rotor-support systems with application to industrial ventilators

    Science.gov (United States)

    Parszewski, Z.; Krodkiemski, T.; Marynowski, K.

    1980-01-01

    Rotor support systems interaction with parametric excitation is considered for both unequal principal shaft stiffness (generators) and offset disc rotors (ventilators). Instability regions and types of instability are computed in the first case, and parametric resonances in the second case. Computed and experimental results are compared for laboratory machine models. A field case study of parametric vibrations in industrial ventilators is reported. Computed parametric resonances are confirmed in field measurements, and some industrial failures are explained. Also the dynamic influence and gyroscopic effect of supporting structures are shown and computed.

  15. Radiation-induced genomic instability, and the cloning and functional analysis of its related gene

    International Nuclear Information System (INIS)

    Muto, Masahiro; Kanari, Yasuyoshi; Kubo, Eiko; Yamada, Yutaka

    2000-01-01

    Exposure to ionizing radiation produces a number of biological consequences including gene mutations, chromosome aberrations, cellular transformation and cell death. The classical view has been that mutations occur at the sites of DNA damage, that is, damage produced by radiation is converted into a mutation during subsequent DNA replication or as a consequence of enzymatic repair processes. However, many investigators have presented evidence for an alternative mechanism to explain these biological effects. This evidence suggests that radiation may induce a process of genomic instability that is transmissible over many generations of cell replication and that serves to enhance the probability of the occurrence of such genetic effects among the progeny of the irradiated cell after many generations of cell replication. If such a process exists in vivo, it could have significant implications for mechanisms of carcinogenesis. Exposure of B10 mice to fractionated X-irradiation induces a high incidence of thymic lymphomas, whereas the incidence in STS/A mice is very low. Such strain differences are presumably determined genetically, and various genetic factors have been reported to be involved in radiation-induced lymphomagenesis. The mechanism of radiation-induced lymphomagenesis appears to develop through a complex and multistep process. Using this experimental system, we characterized the prelymphoma cells induced by radiation, and identified the genetic changes preceding the development of thymic lymphomas by comparing the oncogenic alterations with the pattern of T cell receptor (TCR) γ rearrangements. In these studies, the latent expression of some chromosomal aberrations and p53 mutations in irradiated progeny has been interpreted to be a manifestation of genomic instability. In the present report we review the results of in vivo studies conducted in our laboratory that support the hypothesis of genomic instability induced by radiation, and we describe the

  16. Lower hybrid parametric instabilities nonuniform pump waves and tokamak applications

    International Nuclear Information System (INIS)

    Berger, R.L.; Chen, L.; Kaw, P.K.; Perkins, F.W.

    1976-11-01

    Electrostatic lower hybrid ''pump'' waves often launched into tokamak plasmas by structures (e.g., waveguides) whose dimensions are considerably smaller than characteristic plasma sizes. Such waves propagate in well-defined resonance cones and give rise to parametric instabilities driven by electron E x B velocities. The finite size of the resonance cone region determines the threshold for both convective quasimode decay instabilities and absolute instabilities. The excitation of absolute instabilities depends on whether a travelling or standing wave pump model is used; travelling wave pumps require the daughter waves to have a definite frequency shift. Altogether, parametric instabilities driven by E x B velocities occur for threshold fields significantly below the threshold for filamentation instabilities driven by pondermotive forces. Applications to tokamak heating show that nonlinear effects set in when a certain power-per-wave-launching port is exceeded

  17. Compact dispersion relations for parametric instabilities of electromagnetic waves in magnetized plasmas

    International Nuclear Information System (INIS)

    Cohen, B.I.

    1987-01-01

    The existence of compact dispersion relations for parametric instabilities of coherent electromagnetic waves in magnetized plasmas is addressed here. In general, comprehensive dispersion relations for parametric instabilities in unmagnetized plasmas become more complicated in the presence of an applied time-independent magnetic field. This is demonstrated with a fluid perturbation theory. A compact dispersion relation for parametric instabilities in unmagnetized plasma is heuristically extended here to the case of a magnetized plasma. This dispersion relation gives the correct results in a variety of circumstances of interest in considering electron cyclotron heating applications

  18. Parametric dependence of density limits in the Tokamak Experiment for Technology Oriented Research (TEXTOR): Comparison of thermal instability theory with experiment

    International Nuclear Information System (INIS)

    Kelly, F.A.; Stacey, W.M.; Rapp, J.

    2001-01-01

    The observed dependence of the TEXTOR [Tokamak Experiment for Technology Oriented Research: E. Hintz, P. Bogen, H. A. Claassen et al., Contributions to High Temperature Plasma Physics, edited by K. H. Spatschek and J. Uhlenbusch (Akademie Verlag, Berlin, 1994), p. 373] density limit on global parameters (I, B, P, etc.) and wall conditioning is compared with the predicted density limit parametric scaling of thermal instability theory. It is necessary first to relate the edge parameters of the thermal instability theory to n(bar sign) and the other global parameters. The observed parametric dependence of the density limit in TEXTOR is generally consistent with the predicted density limit scaling of thermal instability theory. The observed wall conditioning dependence of the density limit can be reconciled with the theory in terms of the radiative emissivity temperature dependence of different impurities in the plasma edge. The thermal instability theory also provides an explanation of why symmetric detachment precedes radiative collapse for most low power shots, while a multifaceted asymmetric radiation from the edge MARFE precedes detachment for most high power shots

  19. Self-Induced Faraday Instability Laser

    Science.gov (United States)

    Perego, A. M.; Smirnov, S. V.; Staliunas, K.; Churkin, D. V.; Wabnitz, S.

    2018-05-01

    We predict the onset of self-induced parametric or Faraday instabilities in a laser, spontaneously caused by the presence of pump depletion, which leads to a periodic gain landscape for light propagating in the cavity. As a result of the instability, continuous wave oscillation becomes unstable even in the normal dispersion regime of the cavity, and a periodic train of pulses with ultrahigh repetition rate is generated. Application to the case of Raman fiber lasers is described, in good quantitative agreement between our conceptual analysis and numerical modeling.

  20. The effect of transverse crack upon parametric instability of a rotor-bearing system with an asymmetric disk

    Science.gov (United States)

    Han, Qinkai; Chu, Fulei

    2012-12-01

    It is well known that either the asymmetric disk or transverse crack brings parametric inertia (or stiffness) excitation to the rotor-bearing system. When both of them appear in a rotor system, the parametric instability behaviors have not gained sufficient attentions. Thus, the effect of transverse crack upon parametric instability of a rotor-bearing system with an asymmetric disk is studied. First, the finite element equations of motion are established for the asymmetric rotor system. Both the open and breathing transverse cracks are taken into account in the model. Then, the discrete state transition matrix (DSTM) method is introduced for numerically acquiring the instability regions. Based upon these, some computations for a practical asymmetric rotor system with open or breathing transverse crack are conducted, respectively. Variations of the primary and combination instability regions induced by the asymmetric disk with the crack depth are observed, and the effect of the orientation angle between the crack and asymmetric disk on various instability regions are discussed in detail. It is shown that for the asymmetric angle around 0, the existence of transverse (either open or breathing) crack has attenuation effect upon the instability regions. Under certain crack depth, the instability regions could be vanished by the transverse crack. When the asymmetric angle is around π/2, increasing the crack depth would enhance the instability regions.

  1. The effect of a laser beam displacement on parametric oscillatory instabilities for Advanced LIGO

    International Nuclear Information System (INIS)

    Heinert, D.; Strigin, S.E.

    2011-01-01

    The arm cavities of real gravitational wave detectors can show small deviations like a tilt or a spatial shift between the cavity mirrors. These deviations lead to a separation of the optical mode centres with respect to the mirror's centre. In this Letter we perform the computation of parametric instable modes considering the described displacement. We further analyse the possibility of parametric oscillatory instability in the Advanced LIGO interferometer for the case of a displaced arm cavity. Our results reveal an additional number of optical and elastic mode combinations due to a displacement that can give rise to the undesirable effect of parametric oscillatory instability. -- Highlights: → We analyse the possibility of parametric oscillatory instability in the Advanced LIGO interferometer. → We perform the computation of parametric instable modes considering the mirror displacement. → Our results reveal an additional number of optical and elastic mode unstable combinations.

  2. Induction of genetic instability by ionizing radiation

    International Nuclear Information System (INIS)

    Little, J.B.

    1999-01-01

    Evidence is presented to support the hypothesis that radiation may induce a heritable, genome-wide process of instability that leads to an enhanced frequency of genetic changes occurring among the progeny of the original irradiated cell. This instability is transmissible over many generations of cell replication. Mutational instability is induced in a relatively large fraction (approximately 10 %) of the cell population, and may be modulated by factors acting in vivo. Thus, it cannot be a targeted event involving a specific gene or set of genes. There is no dose-response relationship in the range 2-12 Gy, suggesting that the instability phenotype may be induced by quite low radiation doses. The molecular mechanisms associated with the genesis of mutations in unstable populations differ from those for direct X-ray-induced mutations. These results suggest that it may not be possible to predict the nature of the dose-response relationship for the ultimate genetic effects of radiation based on a qualitative or quantitative analysis of the original DNA lesions. (author)

  3. Observational Signatures of Parametric Instability at 1AU

    Science.gov (United States)

    Bowen, T. A.; Bale, S. D.; Badman, S.

    2017-12-01

    Observations and simulations of inertial compressive turbulence in the solar wind are characterized by density structures anti-correlated with magnetic fluctuations parallel to the mean field. This signature has been interpreted as observational evidence for non-propagating pressure balanced structures (PBS), kinetic ion acoustic waves, as well as the MHD slow mode. Recent work, specifically Verscharen et al. (2017), has highlighted the unexpected fluid like nature of the solar wind. Given the high damping rates of parallel propagating compressive fluctuations, their ubiquity in satellite observations is surprising and suggests the presence of a driving process. One possible candidate for the generation of compressive fluctuations in the solar wind is the parametric instability, in which large amplitude Alfvenic fluctuations decay into parallel propagating compressive waves. This work employs 10 years of WIND observations in order to test the parametric decay process as a source of compressive waves in the solar wind through comparing collisionless damping rates of compressive fluctuations with growth rates of the parametric instability. Preliminary results suggest that generation of compressive waves through parametric decay is overdamped at 1 AU. However, the higher parametric decay rates expected in the inner heliosphere likely allow for growth of the slow mode-the remnants of which could explain density fluctuations observed at 1AU.

  4. Genomic instability and radiation effects

    International Nuclear Information System (INIS)

    Christian Streffer

    2007-01-01

    Complete text of publication follows. Cancer, genetic mutations and developmental abnormalities are apparently associated with an increased genomic instability. Such phenomena have been frequently shown in human cancer cells in vitro and in situ. It is also well-known that individuals with a genetic predisposition for cancer proneness, such as ataxia telangiectesia, Fanconi anaemia etc. demonstrate a general high genomic instability e.g. in peripheral lymphocytes before a cancer has developed. Analogous data have been found in mice which develop a specific congenital malformation which has a genetic background. Under these aspects it is of high interest that ionising radiation can increase the genomic instability of mammalian cells after exposures in vitro an in vivo. This phenomenon is expressed 20 to 40 cell cycles after the exposure e.g. by de novo chromosomal aberrations. Such effects have been observed with high and low LET radiation, high LET radiation is more efficient. With low LET radiation a good dose response is observed in the dose range 0.2 to 2.0 Gy, Recently it has been reported that senescence and genomic instability was induced in human fibroblasts after 1 mGy carbon ions (1 in 18 cells are hit), apparently bystander effects also occurred under these conditions. The instability has been shown with DNA damage, chromosomal aberrations, gene mutation and cell death. It is also transferred to the next generation of mice with respect to gene mutations, chromosomal aberrations and congenital malformations. Several mechanisms have been discussed. The involvement of telomeres has gained interest. Genomic instability seems to be induced by a general lesion to the whole genome. The transmission of one chromosome from an irradiated cell to an non-irradiated cell leads to genomic instability in the untreated cells. Genomic instability increases mutation rates in the affected cells in general. As radiation late effects (cancer, gene mutations and congenital

  5. The influence of dual-recycling on parametric instabilities at Advanced LIGO

    International Nuclear Information System (INIS)

    Green, A C; Brown, D D; Dovale-Álvarez, M; Collins, C; Miao, H; Mow-Lowry, C M; Freise, A

    2017-01-01

    Laser interferometers with high circulating power and suspended optics, such as the LIGO gravitational wave detectors, experience an optomechanical coupling effect known as a parametric instability : the runaway excitation of a mechanical resonance in a mirror driven by the optical field. This can saturate the interferometer sensing and control systems and limit the observation time of the detector. Current mitigation techniques at the LIGO sites are successfully suppressing all observed parametric instabilities, and focus on the behaviour of the instabilities in the Fabry–Perot arm cavities of the interferometer, where the instabilities are first generated. In this paper we model the full dual-recycled Advanced LIGO design with inherent imperfections. We find that the addition of the power- and signal-recycling cavities shapes the interferometer response to mechanical modes, resulting in up to four times as many peaks. Changes to the accumulated phase or Gouy phase in the signal-recycling cavity have a significant impact on the parametric gain, and therefore which modes require suppression. (paper)

  6. Scaling of plasma turbulence resulting from parametric instabilities

    International Nuclear Information System (INIS)

    Ott, E.

    1976-01-01

    Dimensional analysis is used to obtain results on the turbulent state resulting from parametric instabilities of an initially cold plasma. The results include the possibility of an applied magnetic field, multiple ion species, and arbitrary dimensionality

  7. Parametric instabilities excited by localized pumps near the lower-hybrid frequency

    International Nuclear Information System (INIS)

    Kuo, Y.Y.; Chen, L.

    1976-04-01

    Parametric instabilities excited in non-uniform plasmas by spatially localized pump fields oscillating near the local lower-hybrid frequency are analytically investigated. Corresponding threshold conditions, temporal growth rates, and spatial amplification factors are obtained for the oscillating-two-stream instability and the decay instabilities due to nonlinear electron and ion Landau dampings

  8. Lack of specificity of chromosome breaks resulting from radiation-induced genomic instability in Chinese hamster cells

    International Nuclear Information System (INIS)

    Trott, K.-R.; Teibe, A.

    1998-01-01

    In V79 Chinese hamster cells, radiation-induced genomic instability results in a persistently increased frequency of micronuclei, dicentric chromosomes and apoptosis and in decreased colony-forming ability. These manifestations of radiation-induced genomic instability may be attributed to an increased rate of chromosome breakage events many generations after irradiation. This chromosomal instability does not seem to be a property which has been inflicted on individual chromosomes at the time of irradiation. Rather, it appears to be secondary to an increased level of non-specific clastogenic factors in the progeny of most if not all irradiated cells. This conclusion is drawn from the observations presented here, that all the chromosomes in surviving V79 cells are involved in the formation of dicentric chromosome aberrations 1 or 2 weeks after irradiation with about equal probability if corrections are made for chromosome length. (orig.)

  9. Parametric instabilities of parallel propagating incoherent Alfven waves in a finite ion beta plasma

    International Nuclear Information System (INIS)

    Nariyuki, Y.; Hada, T.; Tsubouchi, K.

    2007-01-01

    Large amplitude, low-frequency Alfven waves constitute one of the most essential elements of magnetohydrodynamic (MHD) turbulence in the fast solar wind. Due to small collisionless dissipation rates, the waves can propagate long distances and efficiently convey such macroscopic quantities as momentum, energy, and helicity. Since loading of such quantities is completed when the waves damp away, it is important to examine how the waves can dissipate in the solar wind. Among various possible dissipation processes of the Alfven waves, parametric instabilities have been believed to be important. In this paper, we numerically discuss the parametric instabilities of coherent/incoherent Alfven waves in a finite ion beta plasma using a one-dimensional hybrid (superparticle ions plus an electron massless fluid) simulation, in order to explain local production of sunward propagating Alfven waves, as suggested by Helios/Ulysses observation results. Parameter studies clarify the dependence of parametric instabilities of coherent/incoherent Alfven waves on the ion and electron beta ratio. Parametric instabilities of coherent Alfven waves in a finite ion beta plasma are vastly different from those in the cold ions (i.e., MHD and/or Hall-MHD systems), even if the collisionless damping of the Alfven waves are neglected. Further, ''nonlinearly driven'' modulational instability is important for the dissipation of incoherent Alfven waves in a finite ion beta plasma regardless of their polarization, since the ion kinetic effects let both the right-hand and left-hand polarized waves become unstable to the modulational instability. The present results suggest that, although the antisunward propagating dispersive Alfven waves are efficiently dissipated through the parametric instabilities in a finite ion beta plasma, these instabilities hardly produce the sunward propagating waves

  10. Effects of three-body interactions in the parametric and modulational instabilities of Bose–Einstein condensates

    International Nuclear Information System (INIS)

    Wamba, Etienne; Mohamadou, Alidou; Ekogo, Thierry B.; Atangana, Jacque; Kofane, Timoleon C.

    2011-01-01

    The parametric modulational instability for a discrete nonlinear Schrödinger equation with a cubic–quintic nonlinearity is analyzed. This model describes the dynamics of BECs, with both two- and three-body interatomic interactions trapped in an optical lattice. We identify and discuss the salient features of the three-body interaction in the parametric modulational instability. It is shown that the three-body interaction term can both, shift as well as narrow the window of parametric instability, and also change the behavior of a modulationally stable and parametrically unstable BEC with attractive two-body interaction. We explore this instability through the multiple-scale analysis and identify it numerically. The effect of the three body losses have also been investigated. -- Highlights: ► The parametric MI for the 1D GPE with a cubic–quintic nonlinearity is analyzed. ► The two- and three-body recombination and time-dependent scattering length is considered. ► We generate bright matter waves soliton through MI.

  11. Measurements of parametric instability near the critical density and the resultant electron heating: Final report

    International Nuclear Information System (INIS)

    Mizuno, K.; De Groot, J.S.; Seka, W.

    1986-01-01

    Detailed studies of the ion acoustic parametric decay instability have been made. Theoretical and particle simulation results indicate these instabilities are important in long scale length plasma irradiated by moderate intensity laser light (10'' ≤ Iλ 2 /T/sub e/ (W/cm 2 ) (μm 2 )/(keV) ≤ 5 x 10 14 ). Laser light (λ 0 ≅ 1/2 μm) is focused onto a CH target. The parametric decay instability has been measured by detecting the emission spectrum at frequencies near 2ω 0 . The experimental results clearly indicate that this parametric instability is important for short wavelength (1/2 μm) laser light irradiation. The threshold of the parametric instability (λ 0 = 1/2 μm) was only slightly higher than that of 1 μm laser case. The measured wavelength shift of the Stokes component (λ 0 = 1/2 μm) compared very well with the 1 μm laser results

  12. A general theory of electronic parametric instability of relativistically intense laser light in plasma

    International Nuclear Information System (INIS)

    Parr, D.M.

    2000-04-01

    This thesis studies the propagation and stability of ultraintense laser light in plasma. A new method is devised, both general and inclusive yet requiring only modest computational effort. The exact anharmonic waveforms for laser light are established. An examination of their stability extends the theory of electron parametric instabilities to relativistic regimes in plasmas of any density including classically overdense plasma accessible by self-induced transparency. Such instabilities can rapidly degrade intense pulses, but can also be harnessed, for example in the self-resonant laser wakefield accelerator. Understanding both the new and established regimes is thus basic to the success of many applications arising in high-field science, including novel x-ray sources and ignition of laser fusion targets, as well as plasma-based accelerator schemes. A covariant formulation of a cold electron fluid plasma is Lorentz transformed to the laser group velocity frame; this is the essence of the method and produces a very simple final model. Then, first, the zero-order laser 'driver' model is developed, in this frame representing a spatially homogeneous environment and thus soluble numerically as ordinary differential equations. The linearised first-order system leads to a further set of differential equations, whose solution defines the growth and other characteristics of an instability. The method is exact, rugged and flexible, avoiding the many approximations and restrictions previously necessary. This approach unifies all theory on purely electronic parametric instabilities over the last 30 years and, for the first time in generality, extends it into the ultrahigh relativistic regime. Besides extensions to familiar parametric instabilities, such as Stimulated Raman Scattering and Two-Plasmon Decay, strong stimulated harmonic generation emerges across a wide range of harmonics with high growth rates, presenting a varied and complex physical entity

  13. A variational approach to parametric instabilities in inhomogeneous plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Afeyan, B.B.

    1993-12-31

    A variational principle is constructed for the pump strength of a three-wave parametric instability in a spatially nonuniform medium. Using this expression together with appropriate trial functions, analytic estimates of the growth rate of the most unstable mode of a given parametric instability may be calculated. The usefullness of the variational method is first demonstrated on the Rosenbluth model problem with a power-law phase-mismatch, followed by a treatment of the Liu, Rosenbluth, and White sidescattering model equation. Two particular instabilities which are of interest in laser fusion and laser-plasma interaction experiments are treated next. These are Stimulated Raman Scattering and Two-Plasmon Decay. Various incidence and scattering geometries, and different density profiles are considered. Previously known results are reproduced in a unified manner and extended to cases where the usual local-expansion techniques do not apply. In particular, using the variational approach, the growth rate of the Two-Plasmon Decay instability occurring at or anywhere below the apex of a parabolic density profile is obtained for the first time. Similarly, Stimulated Raman Scattering from a density extremum at or anywhere below quarter critical, and for all scattering angles from backscattering to sidescattering inclusively is considered for the first time. The limit where the Two-Plasmon Decay and Stimulated Raman Scattering instabilities merge and become indistinguishable is also treated.

  14. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro

    Science.gov (United States)

    Morgan, William F.

    2003-01-01

    A long-standing dogma in the radiation sciences is that energy from radiation must be deposited in the cell nucleus to elicit a biological effect. A number of non-targeted, delayed effects of ionizing radiation have been described that challenge this dogma and pose new challenges to evaluating potential hazards associated with radiation exposure. These effects include induced genomic instability and non-targeted bystander effects. The in vitro evidence for non-targeted effects in radiation biology will be reviewed, but the question as to how one extrapolates from these in vitro observations to the risk of radiation-induced adverse health effects such as cancer remains open.

  15. Radiation-induced genomic instability: Are epigenetic mechanisms the missing link?

    Energy Technology Data Exchange (ETDEWEB)

    Aypar, Umut; Morgan, William F.; Baulch, Janet E.

    2011-02-01

    Purpose: This review examines the evidence for the hypothesis that epigenetics are involved in the initiation and perpetuation of radiation-induced genomic instability (RIGI). Conclusion: In addition to the extensively studied targeted effects of radiation, it is now apparent that non-targeted delayed effects such as RIGI are also important post-irradiation outcomes. In RIGI, unirradiated progeny cells display phenotypic changes at delayed times after radiation of the parental cell. RIGI is thought to be important in the process of carcinogenesis, however, the mechanism by which this occurs remains to be elucidated. In the genomically unstable clones developed by Morgan and colleagues, radiation-induced mutations, double-strand breaks, or changes in mRNA levels alone could not account for the initiation or perpetuation of RIGI. Since changes in the DNA sequence could not fully explain the mechanism of RIGI, inherited epigenetic changes may be involved. Epigenetics are known to play an important role in many cellular processes and epigenetic aberrations can lead to carcinogenesis. Recent studies in the field of radiation biology suggest that the changes in methylation patterns may be involved in RIGI. Together these clues have led us to hypothesize that epigenetics may be the missing link in understanding the mechanism behind RIGI.

  16. Role of parametric decay instabilities in generating ionospheric irregularities

    International Nuclear Information System (INIS)

    Kuo, S.P.; Cheo, B.R.; Lee, M.C.

    1983-01-01

    We show that purely growing instabilities driven by the saturation spectrum of parametric decay instabilities can produce a broad spectrum of ionospheric irregularities. The threshold field Vertical BarE/sub th/Vertical Bar of the instabilities decreases with the scale lengths lambda of the ionospheric irregularities as Vertical BarE/sub th/Vertical Barproportionallambda -2 in the small-scale range ( -2 with scale lengths larger than a few kilometers. The excitation of kilometer-scale irregularities is strictly restricted by the instabilities themselves and by the spatial inhomogeneity of the medium. These results are drawn from the analyses of four-wave interaction. Ion-neutral collisions impose no net effect on the instabilities when the excited ionospheric irregularities have a field-aligned nature

  17. The Role of DNA Methylation Changes in Radiation-Induced Transgenerational Genomic Instability and Bystander Effects in cranial irradiated Mice

    Science.gov (United States)

    Zhang, Meng; Sun, Yeqing; Gao, Yinglong; Zhang, Baodong

    Heavy-ion radiation could lead to genome instability in the germline, and therefore to transgenerational genome and epigenome instability in offspring of exposed males. The exact mechanisms of radiation-induced genome instability in directly exposed and in bystander organ remain obscure, yet accumulating evidence points to the role of DNA methylation changes in genome instability development. The potential of localized body-part exposures to affect the germline and thus induce genome and epigenome changes in the progeny has not been studied. To investigate whether or not the paternal cranial irradiation can exert deleterious changes in the protected germline and the offsprings, we studied the alteration of DNA methylation in the shielded testes tissue. Here we report that the localized paternal cranial irradiation results in a significant altered DNA methylation in sperm cells and leads to a profound epigenetic dysregulation in the unexposed progeny conceived 3 months after paternal exposure. The possible molecular mechanisms and biological consequences of the observed changes are discussed. Keywords: Heavy-ion radiation; Transgenerational effect; Genomic Instability Bystander Effects; DNA methylation.

  18. Study of genomic instability induced by low dose ionizing radiation

    International Nuclear Information System (INIS)

    Seoane, A.; Crudeli, C.; Dulout, F.

    2006-01-01

    The crews of commercial flights and services staff of radiology and radiotherapy from hospitals are exposed to low doses of ionizing radiation. Genomic instability includes those adverse effects observed in cells, several generations after the exposure occurred. The purpose of this study was to analyze the occurrence of genomic instability by very low doses of ionizing radiation [es

  19. Possible parametric instabilities of beat waves in a transversely magnetized plasma

    International Nuclear Information System (INIS)

    Salimullah, M.

    1988-05-01

    The effect of an external magnetic field on the various possible parametric instabilities of the longitudinal beat wave at the difference frequency of two incident laser beams in a hot plasma has been thoeretically investigated. The kinetic equation is employed to obtain the nonlinear response of the magnetized electrons due to the nonlinear coupling of the beat wave with the low-frequency electrostatic plasma modes. It is noted that the growth rates of the three-wave and the four-wave parametric instabilities can be influenced by the external transverse magnetic field. (author). 20 refs, 3 figs

  20. Absolute parametric instability in a nonuniform plane plasma

    Indian Academy of Sciences (India)

    The paper reports an analysis of the effect of spatial plasma nonuniformity on absolute parametric instability (API) of electrostatic waves in magnetized plane waveguides subjected to an intense high-frequency (HF) electric field using the separation method. In this case the effect of strong static magnetic field is considered.

  1. Absolute parametric instability in a nonuniform plane plasma ...

    Indian Academy of Sciences (India)

    Abstract. The paper reports an analysis of the effect of spatial plasma nonuniformity on absolute parametric instability (API) of electrostatic waves in magnetized plane waveguides subjected to an intense high-frequency (HF) electric field using the separation method. In this case the effect of strong static magnetic field is ...

  2. Chaos of radiative heat-loss-induced flame front instability.

    Science.gov (United States)

    Kinugawa, Hikaru; Ueda, Kazuhiro; Gotoda, Hiroshi

    2016-03-01

    We are intensively studying the chaos via the period-doubling bifurcation cascade in radiative heat-loss-induced flame front instability by analytical methods based on dynamical systems theory and complex networks. Significant changes in flame front dynamics in the chaotic region, which cannot be seen in the bifurcation diagrams, were successfully extracted from recurrence quantification analysis and nonlinear forecasting and from the network entropy. The temporal dynamics of the fuel concentration in the well-developed chaotic region is much more complicated than that of the flame front temperature. It exhibits self-affinity as a result of the scale-free structure in the constructed visibility graph.

  3. Local parametric instability near elliptic points in vortex flows under shear deformation

    Energy Technology Data Exchange (ETDEWEB)

    Koshel, Konstantin V., E-mail: kvkoshel@poi.dvo.ru [Pacific Oceanological Institute, FEB RAS, 43, Baltiyskaya Street, Vladivostok 690041 (Russian Federation); Institute of Applied Mathematics, FEB RAS, 7, Radio Street, Vladivostok 690022 (Russian Federation); Far Eastern Federal University, 8, Sukhanova Street, Vladivostok 690950 (Russian Federation); Ryzhov, Eugene A., E-mail: ryzhovea@gmail.com [Pacific Oceanological Institute, FEB RAS, 43, Baltiyskaya Street, Vladivostok 690041 (Russian Federation)

    2016-08-15

    The dynamics of two point vortices embedded in an oscillatory external flow consisted of shear and rotational components is addressed. The region associated with steady-state elliptic points of the vortex motion is established to experience local parametric instability. The instability forces the point vortices with initial positions corresponding to the steady-state elliptic points to move in spiral-like divergent trajectories. This divergent motion continues until the nonlinear effects suppress their motion near the region associated with the steady-state separatrices. The local parametric instability is then demonstrated not to contribute considerably to enhancing the size of the chaotic motion regions. Instead, the size of the chaotic motion region mostly depends on overlaps of the nonlinear resonances emerging in the perturbed system.

  4. Possible radioprotective effect of folic acid supplementation on low dose ionizing radiation-induced genomic instability in vitro.

    Science.gov (United States)

    Padula, Gisel; Ponzinibbio, María Virginia; Seoane, Analia I

    2016-08-01

    Ionizing radiation (IR) induces DNA damage through production of single and double-strand breaks and reactive oxygen species (ROS). Folic acid (FA) prevents radiation-induced DNA damage by modification of DNA synthesis and/or repair and as a radical scavenger. We hypothesized that in vitro supplementation with FA will decrease the sensitivity of cells to genetic damage induced by low dose of ionizing radiation. Annexin V, comet and micronucleus assays were performed in cultured CHO cells. After 7 days of pre-treatment with 0, 100, 200 or 300 nM FA, cultures were exposed to radiation (100 mSv). Two un-irradiated controls were executed (0 and 100 nM FA). Data were statistically analyzed with X2-test and linear regression analysis (P 0.05). We observed a significantly decreased frequency of apoptotic cells with the increasing FA concentration (P <0.05). The same trend was observed when analyzing DNA damage and chromosomal instability (P <0.05 for 300 nM). Only micronuclei frequencies showed significant differences for linear regression analysis (R2=94.04; P <0.01). Our results have demonstrated the radioprotective effect of folic acid supplementation on low dose ionizing radiation-induced genomic instability in vitro; folate status should be taken into account when studying the effect of low dose radiation in environmental or occupational exposure.

  5. The role of radiation types and dose in induced genomic instability

    International Nuclear Information System (INIS)

    Kadhim Munira, A.

    2007-01-01

    Complete text of publication follows. Genomic Instability (GI) is defined as long-term alterations induced by low-dose exposure to a variety of genotoxic agents in mammalian cells that act to increase the 'apparent' spontaneous mutation frequency.GI is a hallmark of tumorigenic progression and is observed in the progeny of irradiated and bystander cells as the delayed and stochastic appearance of de novo chromosomal aberrations, gene mutations and delayed lethal mutations both in vitro and in vivo. It occurs at a frequency several orders of magnitude greater than would be expected for mutation in a single gene, implying that GI is a multigenic phenomenon. The expression of GI can be influenced by genotype, cell type and radiation quality; however the underlying mechanisms are not fully understood. While several studies have demonstrated GI induction by high and low LET radiation, our work on human and mouse primary cell systems has shown significant differences in the capacity to induce GI and the spectrum of alterations depending on LET. These differences might be attributed to differences in radiation track structure, radiation dose and radiation exposure regime (distribution of hit and un hit cells). In this presentation I shall review the role of radiation quality; describe the possible mechanisms underlining the observed differences between radiation type and present results of experiments demonstrating that the dose of low LET radiation might be the most significant factor in determining the role of radiation type in the induction of GI.

  6. Parametric instabilities in resonantly-driven Bose–Einstein condensates

    Science.gov (United States)

    Lellouch, S.; Goldman, N.

    2018-04-01

    Shaking optical lattices in a resonant manner offers an efficient and versatile method to devise artificial gauge fields and topological band structures for ultracold atomic gases. This was recently demonstrated through the experimental realization of the Harper–Hofstadter model, which combined optical superlattices and resonant time-modulations. Adding inter-particle interactions to these engineered band systems is expected to lead to strongly-correlated states with topological features, such as fractional Chern insulators. However, the interplay between interactions and external time-periodic drives typically triggers violent instabilities and uncontrollable heating, hence potentially ruling out the possibility of accessing such intriguing states of matter in experiments. In this work, we study the early-stage parametric instabilities that occur in systems of resonantly-driven Bose–Einstein condensates in optical lattices. We apply and extend an approach based on Bogoliubov theory (Lellouch et al 2017 Phys. Rev. X 7 021015) to a variety of resonantly-driven band models, from a simple shaken Wannier–Stark ladder to the more intriguing driven-induced Harper–Hofstadter model. In particular, we provide ab initio numerical and analytical predictions for the stability properties of these topical models. This work sheds light on general features that could guide current experiments to stable regimes of operation.

  7. Parametrization of the radiation induced leakage current increase of NMOS transistors

    International Nuclear Information System (INIS)

    Backhaus, M.

    2017-01-01

    The increase of the leakage current of NMOS transistors during exposure to ionizing radiation is known and well studied. Radiation hardness by design techniques have been developed to mitigate this effect and have been successfully used. More recent developments in smaller feature size technologies do not make use of these techniques due to their drawbacks in terms of logic density and requirement of dedicated libraries. During operation the resulting increase of the supply current is a serious challenge and needs to be considered during the system design. A simple parametrization of the leakage current of NMOS transistors as a function of total ionizing dose is presented. The parametrization uses a transistor transfer characteristics of the parasitic transistor along the shallow trench isolation to describe the leakage current of the nominal transistor. Together with a parametrization of the number of positive charges trapped in the silicon dioxide and number of activated interface traps in the silicon to silicon dioxide interface the leakage current results as a function of the exposure time to ionizing radiation. This function is fitted to data of the leakage current of single transistors as well as to data of the supply current of full ASICs.

  8. Parametric instability analysis of truncated conical shells using the Haar wavelet method

    Science.gov (United States)

    Dai, Qiyi; Cao, Qingjie

    2018-05-01

    In this paper, the Haar wavelet method is employed to analyze the parametric instability of truncated conical shells under static and time dependent periodic axial loads. The present work is based on the Love first-approximation theory for classical thin shells. The displacement field is expressed as the Haar wavelet series in the axial direction and trigonometric functions in the circumferential direction. Then the partial differential equations are reduced into a system of coupled Mathieu-type ordinary differential equations describing dynamic instability behavior of the shell. Using Bolotin's method, the first-order and second-order approximations of principal instability regions are determined. The correctness of present method is examined by comparing the results with those in the literature and very good agreement is observed. The difference between the first-order and second-order approximations of principal instability regions for tensile and compressive loads is also investigated. Finally, numerical results are presented to bring out the influences of various parameters like static load factors, boundary conditions and shell geometrical characteristics on the domains of parametric instability of conical shells.

  9. Parametric instabilities in an electron beam plasma system

    International Nuclear Information System (INIS)

    Nakach, R.; Cuperman, S.; Gell, Y.; Levush, B.

    1981-01-01

    The excitation of low frequency parametric instabilities by a finite wave length pump in a system consisting of a warm electron plasma traversed by a warm electron beam is investigated in a fluid dissipationless model. The dispersion relation for the three-dimensional problem in a magnetized plasma with arbitrary directions for the waves is derived, and the one-dimensional case is analyzed numerically. For the one-dimensional back-scattering decay process, it is found that when the plasma-electron Debye length (lambda sub(D)sup(p)) is larger than the beam-electron Debye length (lambda sub(D)sup(b)), two low frequency electrostatic instability branches with different growth rates may simultaneously exist. When lambda sub(D)sup(p) approximately lambda sub(D)sup(b), the large growth rate instability found in the analysis depends strongly on the amplitude of the pump field. In the case (lambda sub(D)sup(p) < lambda sub(D)sup(b)) only one low frequency instability branch is generally excited

  10. Parametrization of the radiation induced leakage current increase of NMOS transistors

    CERN Document Server

    Backhaus, Malte

    2017-01-13

    The increase of the leakage current of NMOS transistors during exposure to ionizing radiation is known and well studied. Radiation hardness by design techniques have been developed to mitigate this effect and have been successfully used. More recent developments in smaller feature size technologies do not make use of these techniques due to their drawbacks in terms of logic density and requirement of dedicated libraries. During operation the resulting increase of the supply current is a serious challenge and needs to be considered during the system design. A simple parametrization of the leakage current of NMOS transistors as a function of total ionizing dose is presented. The parametrization uses a transistor transfer characteristics of the parasitic transistor along the shallow trench isolation to describe the leakage current of the nominal transistor. Together with a parametrization of the number of positive charges trapped in the silicon dioxide and number of activated interface traps in the silicon to si...

  11. Enhanced micronucleus formation in the descendants of {gamma}-ray-irradiated tobacco cells: Evidence for radiation-induced genomic instability in plant cells

    Energy Technology Data Exchange (ETDEWEB)

    Yokota, Yuichiro, E-mail: yokota.yuichiro@jaea.go.jp [Life Science and Biotechnology Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency, 1233 Watanuki-machi, Takasaki, Gunma 370-1292 (Japan); Funayama, Tomoo; Hase, Yoshihiro [Life Science and Biotechnology Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency, 1233 Watanuki-machi, Takasaki, Gunma 370-1292 (Japan); Hamada, Nobuyuki [Radiation Safety Research Center, Nuclear Technology Research Laboratory, Central Research Institute of Electric Power Industry, 2-11-1 Iwado-kita, Komae, Tokyo 201-8511 (Japan); Kobayashi, Yasuhiko; Tanaka, Atsushi; Narumi, Issay [Life Science and Biotechnology Division, Quantum Beam Science Directorate, Japan Atomic Energy Agency, 1233 Watanuki-machi, Takasaki, Gunma 370-1292 (Japan)

    2010-09-10

    Ionizing radiation-induced genomic instability has been documented in various end points such as chromosomal aberrations and mutations, which arises in the descendants of irradiated mammalian or yeast cells many generations after the initial insult. This study aimed at addressing radiation-induced genomic instability in higher plant tobacco cells. We thus investigated micronucleus (MN) formation and cell proliferation in tobacco cells irradiated with {gamma}-rays and their descendants. In {gamma}-irradiated cells, cell cycle was arrested at G{sub 2}/M phase at around 24 h post-irradiation but released afterward. In contrast, MN frequency peaked at 48 h post-irradiation. Almost half of 40 Gy-irradiated cells had MN at 48 h post-irradiation, but proliferated as actively as sham-irradiated cells up to 120 h post-irradiation. Moreover, the descendants that have undergone at least 22 generations after irradiation still showed a two-fold MN frequency compared to sham-irradiated cells. This is the direct evidence for radiation-induced genomic instability in tobacco cells.

  12. Radiation and chemotherapy bystander effects induce early genomic instability events: telomere shortening and bridge formation coupled with mitochondrial dysfunction.

    LENUS (Irish Health Repository)

    Gorman, Sheeona

    2012-02-01

    The bridge breakage fusion cycle is a chromosomal instability mechanism responsible for genomic changes. Radiation bystander effects induce genomic instability; however, the mechanism driving this instability is unknown. We examined if radiation and chemotherapy bystander effects induce early genomic instability events such as telomere shortening and bridge formation using a human colon cancer explant model. We assessed telomere lengths, bridge formations, mitochondrial membrane potential and levels of reactive oxygen species in bystander cells exposed to medium from irradiated and chemotherapy-treated explant tissues. Bystander cells exposed to media from 2Gy, 5Gy, FOLFOX treated tumor and matching normal tissue showed a significant reduction in telomere lengths (all p values <0.018) and an increase in bridge formations (all p values <0.017) compared to bystander cells treated with media from unirradiated tissue (0Gy) at 24h. There was no significant difference between 2Gy and 5Gy treatments, or between effects elicited by tumor versus matched normal tissue. Bystander cells exposed to media from 2Gy irradiated tumor tissue showed significant depolarisation of the mitochondrial membrane potential (p=0.012) and an increase in reactive oxygen species levels. We also used bystander cells overexpressing a mitochondrial antioxidant manganese superoxide dismutase (MnSOD) to examine if this antioxidant could rescue the mitochondrial changes and subsequently influence nuclear instability events. In MnSOD cells, ROS levels were reduced (p=0.02) and mitochondrial membrane potential increased (p=0.04). These events were coupled with a decrease in percentage of cells with anaphase bridges and a decrease in the number of cells undergoing telomere length shortening (p values 0.01 and 0.028 respectively). We demonstrate that radiation and chemotherapy bystander responses induce early genomic instability coupled with defects in mitochondrial function. Restoring mitochondrial

  13. The problem of induced genomic instability in the child organism under conditions of long-term effect of small radiation doses

    International Nuclear Information System (INIS)

    Suskov, I.I.; Kuz'mina, N.S.

    2001-01-01

    The phenomenological aspects of the genomic instability induced in the descendants of the multi-divided cells having been exposed to the radiation are examined. It is demonstrated that the regularity of the genomic instability induction do not correspond to the classical conception of the radiation genetics (hit principle and target theory). The mechanisms and the biological significance of this new genetic phenomenon in the child organism under conditions of low-intensive effect of small-dose radiation and its connection with the state of health are discussed [ru

  14. Secondary Instabilities and Spatiotemporal Chaos in Parametric Surface Waves

    International Nuclear Information System (INIS)

    Zhang, W.; Vinals, J.

    1995-01-01

    A 2D model is introduced to study the onset of parametric surface waves, their secondary instabilities, and the transition to spatiotemporal chaos. We obtain the stability boundary of a periodic standing wave above onset against Eckhaus, zigzag, and transverse amplitude modulations (TAM), as a function of the control parameter var-epsilon and the wavelength of the pattern. The Eckhaus and TAM boundaries cross at a finite value of var-epsilon, thus explaining the finite threshold for the TAM observed experimentally. At larger values of var-epsilon, a numerical solution reveals a transition to spatiotemporal chaotic states mediated by the TAM instability

  15. Parametric instabilities in inhomogeneous plasma

    International Nuclear Information System (INIS)

    Nicholson, D.R.

    1975-01-01

    The nonlinear coupling of three waves in a plasma is considered. One of the waves is assumed large and constant; its amplitude is the parameter of the parametric instability. The spatial-temporal evolution of the other two waves is treated theoretically, in one dimension, by analytic methods and by direct numerical integration of the basic equations. Various monotonic forms of inhomogeneity are considered; agreement with previous work is found and new results are established. Nonmonotonic inhomogeneities are considered, in the form of turbulence and, as a model problem, in the form of a simple sinusoidal modulation. Relatively small amounts of nonmonotonic inhomogeneity, in the presence of a linear density gradient, are found to destabilize the well-known convective saturation, absolute growth occurring instead. (U.S.)

  16. Comparison of parametric instabilities for different test mass materials in advanced gravitational wave interferometers

    International Nuclear Information System (INIS)

    Ju, L.; Zhao, C.; Gras, S.; Degallaix, J.; Blair, D.G.; Munch, J.; Reitze, D.H.

    2006-01-01

    Following the recognition that parametric instabilities can significantly compromise the performance of advanced laser interferometer gravitational wave detectors, we compare the performance of three different test mass configurations: all fused silica test masses, all sapphire test masses and fused silica inboard test masses with sapphire end test masses. We show that the configuration with sapphire end test masses offers the opportunity for thermal tuning on a time scale comparable to the ring up time of oscillatory instabilities. This approach may enable significant reduction of parametric gain

  17. Heating tokamaks by parametric decay of intense extraordinary mode radiation

    International Nuclear Information System (INIS)

    Elder, G.B.; Perkins, F.W.

    1979-08-01

    Intense electron beam technology has developed coherent, very high power (350 megawatts) microwave sources at frequencies which are a modest fraction of the electron cyclotron frequency in tokamaks. Propagation into a plasma occurs via the extraordinary mode which is subject to parametric decay instabilities in the density range ω/sub o/ 2 2 < ω/sub o/(ω/sub o/ + Ω/sub e/). For an incident wave focused onto a hot spot by a dish antenna of radius rho, the effective threshold power P/sub o/ required to induced effective parametric heating is P/sub o/ approx. = 10 MW x/rho Ω/sub e//ω/sub o/ (T/sub e//1 keV)/sup 3/2/ where x denotes the distance to the hot spot

  18. Radiation-induced ηe-modes

    International Nuclear Information System (INIS)

    Shukla, P.K.; Yu, M.Y.

    1990-01-01

    Impurity radiation in a plasma can cause not only static instabilities, but also dynamic instabilities related to the drift and acoustic waves. Radiative instabilities are of much interest because they are associated with relatively high frequency and short wavelength fluctuations, which have been suspected to be responsible for anomalous electron energy transport in tokamak edge plasmas. In this paper, we consider radiation-induced η e instabilities, taking into account electrostatic effects as well as density and temperature inhomogeneities. Also included are the effects of finite gyroradius and dissipation. It is found that the latter can cause strong linear coupling between the modes of interest. The resulting instabilities can have larger growth rates than the static radiative instability. Analytical expressions for the growth rates and instability regimes are given for the limiting cases of practical interest. In particular, it is shown that the η e -mode can couple to both radiation and dissipation to cause resistive instabilities. The parameter regimes of the original radiative as well as the dissipative modes are thereby broadened and shifted because of the interaction. (author) 3 refs

  19. Study of parametric instabilities during the Alcator C lower hybrid wave heating experiments

    International Nuclear Information System (INIS)

    Takase, Y.

    1983-10-01

    Parametric excitation of ion-cyclotron quasi-modes (ω/sub R/ approx. = nω/sub ci/) and ion-sound quasi-modes (ω/sub R/ approx. = k/sub parallel to/v/sub ti/) during lower hybrid wave heating of tokamak plasmas have been studied in detail. Such instabilities may significantly modify the incident wavenumber spectrum near the plasma edge. Convective losses for these instabilities are high if well-defined resonance cones exist, but they are significantly reduced if the resonance cones spread and fill the plasma volume (or some region of it). These instabilities preferentially excite lower hybrid waves with larger values of n/sub parallel to/ than themselves possess, and the new waves tend to be absorbed near the outer layers of the plasma. Parametric instabilities during lower hybrid heating of Alcator C plasmas have been investigated using rf probes (to study tilde phi and tilde n/sub i/) and CO 2 scattering technique (to study tilde n/sub e/). At lower densities (anti n/sub e/ less than or equal to 0.5 x 10 14 cm -3 ) where waves observed in the plasma interior using CO 2 scattering appear to be localized, parametric decay is very weak. Both ion-sound and ion-cyclotron parametric decay processes have been observed at higher densities (anti n greater than or equal to 1.5 x 10 14 cm -3 ) where waves appear to be unlocalized. Finally, at still higher densities (anti n /sub e/ greater than or equal to 2 x 10 4 cm -3 ) pump depletion has been observed. Above these densities heating and current drive efficiencies are expected to degrade significantly

  20. ASPEN: A fully kinetic, reduced-description particle-in-cell model for simulating parametric instabilities

    International Nuclear Information System (INIS)

    Vu, H.X.; Bezzerides, B.; DuBois, D.F.

    1999-01-01

    A fully kinetic, reduced-description particle-in-cell (RPIC) model is presented in which deviations from quasineutrality, electron and ion kinetic effects, and nonlinear interactions between low-frequency and high-frequency parametric instabilities are modeled correctly. The model is based on a reduced description where the electromagnetic field is represented by three separate temporal envelopes in order to model parametric instabilities with low-frequency and high-frequency daughter waves. Because temporal envelope approximations are invoked, the simulation can be performed on the electron time scale instead of the time scale of the light waves. The electrons and ions are represented by discrete finite-size particles, permitting electron and ion kinetic effects to be modeled properly. The Poisson equation is utilized to ensure that space-charge effects are included. The RPIC model is fully three dimensional and has been implemented in two dimensions on the Accelerated Strategic Computing Initiative (ASCI) parallel computer at Los Alamos National Laboratory, and the resulting simulation code has been named ASPEN. The authors believe this code is the first particle-in-cell code capable of simulating the interaction between low-frequency and high-frequency parametric instabilities in multiple dimensions. Test simulations of stimulated Raman scattering, stimulated Brillouin scattering, and Langmuir decay instability are presented

  1. Parametric Instability, Inverse Cascade, and the 1/f Range of Solar-Wind Turbulence.

    Science.gov (United States)

    Chandran, Benjamin D G

    2018-02-01

    In this paper, weak turbulence theory is used to investigate the nonlinear evolution of the parametric instability in 3D low- β plasmas at wavelengths much greater than the ion inertial length under the assumption that slow magnetosonic waves are strongly damped. It is shown analytically that the parametric instability leads to an inverse cascade of Alfvén wave quanta, and several exact solutions to the wave kinetic equations are presented. The main results of the paper concern the parametric decay of Alfvén waves that initially satisfy e + ≫ e - , where e + and e - are the frequency ( f ) spectra of Alfvén waves propagating in opposite directions along the magnetic field lines. If e + initially has a peak frequency f 0 (at which fe + is maximized) and an "infrared" scaling f p at smaller f with -1 scaling throughout a range of frequencies that spreads out in both directions from f 0 . At the same time, e - acquires an f -2 scaling within this same frequency range. If the plasma parameters and infrared e + spectrum are chosen to match conditions in the fast solar wind at a heliocentric distance of 0.3 astronomical units (AU), then the nonlinear evolution of the parametric instability leads to an e + spectrum that matches fast-wind measurements from the Helios spacecraft at 0.3 AU, including the observed f -1 scaling at f ≳ 3 × 10 -4 Hz. The results of this paper suggest that the f -1 spectrum seen by Helios in the fast solar wind at f ≳ 3 × 10 -4 Hz is produced in situ by parametric decay and that the f -1 range of e + extends over an increasingly narrow range of frequencies as r decreases below 0.3 AU. This prediction will be tested by measurements from the Parker Solar Probe .

  2. Radiation induced genomic instability

    International Nuclear Information System (INIS)

    Morgan, W.

    2003-01-01

    This presentation will focus on delayed genetic effects occurring in the progeny of cells after exposure to ionizing radiation. We have developed a model system for investigating those genetic effects occurring multiple generations after radiation exposure. The presentation will describe some of the delayed effects observed after radiation exposures including delayed chromosomal rearrangements, and recombination events as determined by a plasmid based assay system. We will present new data on how changes in gene expression as measured by differential display and DNA microarray analysis provides a mechanism by which cells display a memory of irradiation, and introduce candidate genes that may play a role in initiating and perpetuation the unstable phenotype. These results will be discussed in terms of the recently described non-targeted Death Inducing Effect (DIE) where by secreted factors from clones of unstable cells can elicit effects in non irradiated cells and may serve to perpetuate the unstable phenotype in cells that themselves were not irradiated

  3. Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis

    Directory of Open Access Journals (Sweden)

    Ifigeneia V. Mavragani

    2017-07-01

    Full Text Available Cellular effects of ionizing radiation (IR are of great variety and level, but they are mainly damaging since radiation can perturb all important components of the cell, from the membrane to the nucleus, due to alteration of different biological molecules ranging from lipids to proteins or DNA. Regarding DNA damage, which is the main focus of this review, as well as its repair, all current knowledge indicates that IR-induced DNA damage is always more complex than the corresponding endogenous damage resulting from endogenous oxidative stress. Specifically, it is expected that IR will create clusters of damage comprised of a diversity of DNA lesions like double strand breaks (DSBs, single strand breaks (SSBs and base lesions within a short DNA region of up to 15–20 bp. Recent data from our groups and others support two main notions, that these damaged clusters are: (1 repair resistant, increasing genomic instability (GI and malignant transformation and (2 can be considered as persistent “danger” signals promoting chronic inflammation and immune response, causing detrimental effects to the organism (like radiation toxicity. Last but not least, the paradigm shift for the role of radiation-induced systemic effects is also incorporated in this picture of IR-effects and consequences of complex DNA damage induction and its erroneous repair.

  4. Parametric instabilities in shallow water magnetohydrodynamics of astrophysical plasma in external magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    Klimachkov, D.A., E-mail: klimachkovdmitry@gmail.com [Space Research Institute of Russian Academy of Science, 84/32, Profsoyuznaya str., Moscow, 117997 (Russian Federation); Petrosyan, A.S. [Space Research Institute of Russian Academy of Science, 84/32, Profsoyuznaya str., Moscow, 117997 (Russian Federation); Moscow Institute of Physics and Technology (State University), 9 Institutskyi per., Dolgoprudny, Moscow Region, 141700 (Russian Federation)

    2017-01-15

    This article deals with magnetohydrodynamic (MHD) flows of a thin rotating layer of astrophysical plasma in external magnetic field. We use the shallow water approximation to describe thin rotating plasma layer with a free surface in a vertical external magnetic field. The MHD shallow water equations with external vertical magnetic field are revised by supplementing them with the equations that are consequences of the magnetic field divergence-free conditions and reveal the existence of third component of the magnetic field in such approximation providing its relation with the horizontal magnetic field. It is shown that the presence of a vertical magnetic field significantly changes the dynamics of the wave processes in astrophysical plasma compared to the neutral fluid and plasma layer in a toroidal magnetic field. The equations for the nonlinear wave packets interactions are derived using the asymptotic multiscale method. The equations for three magneto-Poincare waves interactions, for three magnetostrophic waves interactions, for the interactions of two magneto-Poincare waves and for one magnetostrophic wave and two magnetostrophic wave and one magneto-Poincare wave interactions are obtained. The existence of parametric decay and parametric amplifications is predicted. We found following four types of parametric decay instabilities: magneto-Poincare wave decays into two magneto-Poincare waves, magnetostrophic wave decays into two magnetostrophic waves, magneto-Poincare wave decays into one magneto-Poincare wave and one magnetostrophic wave, magnetostrophic wave decays into one magnetostrophic wave and one magneto-Poincare wave. Following mechanisms of parametric amplifications are found: parametric amplification of magneto-Poincare waves, parametric amplification of magnetostrophic waves, magneto-Poincare wave amplification in magnetostrophic wave presence and magnetostrophic wave amplification in magneto-Poincare wave presence. The instabilities growth rates

  5. Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects

    Science.gov (United States)

    Morgan, William F.

    2003-01-01

    The goal of this review is to summarize the evidence for non-targeted and delayed effects of exposure to ionizing radiation in vivo. Currently, human health risks associated with radiation exposures are based primarily on the assumption that the detrimental effects of radiation occur in irradiated cells. Over the years a number of non-targeted effects of radiation exposure in vivo have been described that challenge this concept. These include radiation-induced genomic instability, bystander effects, clastogenic factors produced in plasma from irradiated individuals that can cause chromosomal damage when cultured with nonirradiated cells, and transgenerational effects of parental irradiation that can manifest in the progeny. These effects pose new challenges to evaluating the risk(s) associated with radiation exposure and understanding radiation-induced carcinogenesis.

  6. Investigation of the Periodic Absolute Parametric Instability in a Nonuniform Cylindrical Warm Plasma Waveguide

    International Nuclear Information System (INIS)

    Zaki, N.G.

    2009-01-01

    In this paper, the effect of spatial plasma nonuniformity on periodic Absolute Parametric Instability (API) of electrostatic waves in a magnetized pump warm plasma is investigated in a cylindrical geometry. An API plays a crucial role in the processes of the energy transfer from the electromagnetic radiation to the plasma and may have an important consequences for experiments on RF plasma heating in a magnetic traps and for a laser-fusion system. In conclusion; it is found that: A) allowance for the spatial nonuniformity of the plasma density leads to A.I) localization of an unstable wave in a finite region of a plasma volume, A.2) increasing the threshold value of the pump wave amplitude above which parametric amplification occurs and A.3) decreasing the value of the growth rate of unstable waves, B) more growth rate of periodic API is decreased due to electrons warmness in comparison with the case of cold plasma, and C) Independent of the geometry of the problem ( plane or cylinder), the results of the API in a warm plasma waveguide are still valid

  7. Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo

    International Nuclear Information System (INIS)

    Koturbash, Igor; Baker, Mike; Loree, Jonathan; Kutanzi, Kristy; Hudson, Darryl; Pogribny, Igor; Sedelnikova, Olga; Bonner, William; Kovalchuk, Olga

    2006-01-01

    Purpose: Although modern cancer radiation therapy has led to increased patient survival rates, the risk of radiation treatment-related complications is becoming a growing problem. Among various complications, radiation also poses a threat to the progeny of exposed parents. It causes transgenerational genome instability that is linked to transgenerational carcinogenesis. Although the occurrence of transgenerational genome instability, which manifests as elevated delayed and nontargeted mutation, has been well documented, the mechanisms by which it arises remain obscure. We hypothesized that epigenetic alterations may play a pivotal role in the molecular etiology of transgenerational genome instability. Methods and Materials: We studied the levels of cytosine DNA methylation in somatic tissues of unexposed offspring upon maternal, paternal, or combined parental exposure. Results: We observed a significant loss of global cytosine DNA methylation in the thymus tissue of the offspring upon combined parental exposure. The loss of DNA methylation was paralleled by a significant decrease in the levels of maintenance (DNMT1) and de novo methyltransferases DNMT3a and 3b and methyl-CpG-binding protein MeCP2. Along with profound changes in DNA methylation, we noted a significant accumulation of DNA strand breaks in thymus, which is a radiation carcinogenesis target organ. Conclusions: The observed changes were indicative of a profound epigenetic dysregulation in the offspring, which in turn could lead to genome destabilization and possibly could serve as precursor for transgenerational carcinogenesis. Future studies are clearly needed to address the cellular and carcinogenic repercussions of those changes

  8. Radiation-induced Genomic Instability and Radiation Sensitivity

    Energy Technology Data Exchange (ETDEWEB)

    Varnum, Susan M.; Sowa, Marianne B.; Kim, Grace J.; Morgan, William F.

    2013-01-19

    The obvious relationships between reactive oxygen and nitrogen species, mitochondrial dysfunction, inflammatory type responses and reactive chemokines and cytokines suggests a general stress response induced by ionizing radiation most likely leads to the non-targeted effects described after radiation exposure. We argue that true bystander effects do not occur in the radiation therapy clinic. But there is no question that effects outside the target volume do occur. These “out of field effects” are considered very low dose effects in the context of therapy. So what are the implications of non-targeted effects on radiation sensitivity? The primary goal of therapy is to eradicate the tumor. Given the genetic diversity of the human population, lifestyle and environment factors it is likely some combination of these will influence patient outcome. Non-targeted effects may contribute to a greater or lesser extent. But consider the potential situation involving a partial body exposure due to a radiation accident or radiological terrorism. Non-targeted effects suggest that the tissue at risk for demonstrating possible detrimental effects of radiation exposure might be greater than the volume actually irradiated.

  9. Parametric decay instabilities in ECR heated plasmas

    International Nuclear Information System (INIS)

    Porkolab, M.

    1982-01-01

    The possibility of parametric excitation of electron Bernstein waves and low frequency ion oscillations during ECR heating at omega/sub o/ approx. = l omega/sub ce/, l = 1,2 is examined. In particular, the thresholds for such instabilities are calculated. It is found that Bernstein waves and lower hybrid quasi-modes have relatively low homogeneous where T/sub e/ approx. = T/sub i/. Thus, these processes may lead to nonlinear absorption and/or scattering of the incident pump wave. The resulting Bernstein waves may lead to either more effective heating (especially during the start-up phase) or to loss of microwave energy if the decay waves propagate out of the system before their energy is absorbed by particles. While at omega/sub o/ = omega/sub UH/ the threshold is reduced due to the WKB enhancement of the pump wave, (and this instability may be important in tokamaks) in EBT's and tandem mirrors the instability at omega /sub o/ greater than or equal to 2 omega/sub ce/ may be important. The instability may persist even if omega > 2 omega/sub ce/ and this may be the case during finite beta depression of the magnetic field in which case the decay waves may be trapped in the local magnetic well so that convective losses are minimized. The excited fluctuations may lead to additional scattering of the ring electrons and the incident microwave fields. Application of these calculations to ECR heating of tokamaks, tandem mirrors, and EBT's will be examined

  10. Genetic alterations during radiation-induced carcinogenesis

    International Nuclear Information System (INIS)

    Kodama, Seiji

    1995-01-01

    This paper reviews radiation-induced genetic alterations and its carcinogenesis, focusing on the previous in vitro assay outcome. A colony formation assay using Syrian hamster fetal cells and focus formation assay using mouse C3H10T1/2 cells are currently available to find malignant transformation of cells. Such in vitro assays has proposed the hypothesis that radiation-induced carcinogenesis arises from at least two-stage processes; i.e., that an early step induced by irradiation plays an important role in promoting the potential to cause the subsequent mutation. A type of genetic instability induced by radiation results in a persistently elevated frequency of spontaneous mutations, so-called the phenomenon of delayed reproductive death. One possible mechanism by which genetic instability arises has been shown to be due to the development of abnormality in the gene group involved in the maintenance mechanism of genome stability. Another possibility has also been shown to stem from the loss of telomere (the extremities of a chromosome). The importance of search for radiation-induced genetic instability is emphasized in view of the elucidation of carcinogenesis. (N.K.)

  11. The role of nonlinear beating currents on parametric instabilities in magnetoplasmas

    International Nuclear Information System (INIS)

    Kuo, S.P.

    1996-01-01

    A general coupled mode equation for the low-frequency decay modes of parametric instabilities in magnetoplasmas is derived. The relative importance of the nonlinear contributions from the ponderomotive force, nonlinear beating current, and anisotropic effect to the parametric coupling is then manifested by the coupling terms of the equation. It is first shown in the unmagnetized case, that the contribution of the nonlinear beating current is negligibly small because of the small coefficient (i.e., weight) of this current contribution, instead of the beating current itself. It then follows that the weight of the beating current contribution increases significantly in the magnetized case, and consequently, this contribution to the parametric coupling is found to be important, as exemplified by two specific examples. copyright 1996 American Institute of Physics

  12. Nonlinear behavior of the radiative condensation instability

    International Nuclear Information System (INIS)

    McCarthy, D.; Drake, J.F.

    1991-01-01

    An investigation of the nonlinear behavior of the radiative condensation instability is presented in a simple one-dimensional magnetized plasma. It is shown that the radiative condensation is typically a nonlinear instability---the growth of the instability is stronger once the disturbance reaches finite amplitude. Moreover, classical parallel thermal conduction is insufficient by itself to saturate the instability. Radiative collapse continues until the temperature in the high density condensation falls sufficiently to reduce the radiation rate

  13. Absolute parametric instability of low-frequency waves in a 2D ...

    Indian Academy of Sciences (India)

    solved in two-dimensional (2D) nonuniform plane plasma. Equations which describe the spatial part of the electric potential are obtained. Also, the growth rates and conditions of the parametric instability for periodic and aperiodic cases are obtained. It is found that the spatial nonuniformity of the plasma exerts a stabilizing ...

  14. Radiation-induced genomic instability and bystander effects: inter-related inflammatory-type non-targeted effects of exposure to ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    Wright, E.G. (Molecular and Cellular Pathology Laboratories, Division of Pathology and Neuroscience, Ninewells Hospital and Medical School, Dundee, Scotland (United Kingdom))

    2008-12-15

    The dogma that genetic alterations are restricted to directly irradiated cells has been challenged by observations in which effects of ionizing radiation, characteristically associated with the consequences of energy deposition in the cell nucleus, arise in non-irradiated cells. These, so called, untargeted effects are demonstrated in cells that are the descendants of irradiated cells (radiation-induced genomic instability) or in cells that have communicated with neighbouring irradiated cells (radiation-induced bystander effects). There are also reports of long-range signals in vivo, known as clastogenic factors, with the capacity to induce damage in unirradiated cells. Clastogenic factors may be related to the inflammatory responses that have been implicated in some of the pathological consequences of radiation exposures. The phenotypic expression of untargeted effects reflects a balance between the type of signals produced and the responses of cell populations to such signals, both of which may be significantly influenced by cell type and genotype. There is accumulating evidence that untargeted effects in vitro involve inter-cellular signalling, production of cytokines and free radical generation. These are also features of inflammatory responses in vivo that are known to have the potential for both bystander-mediated and persisting damage as well as for conferring a predisposition to malignancy. At present it is far from clear how untargeted effects contribute to overall cellular radiation responses and in vivo consequences but it is possible that the various untargeted effects may reflect inter-related aspects of a non-specific inflammatory-type response to radiation-induced stress and injury and be involved in a variety of the pathological consequences of radiation exposures. (orig.)

  15. Radiation-induced genomic instability and bystander effects: inter-related inflammatory-type non-targeted effects of exposure to ionizing radiation

    International Nuclear Information System (INIS)

    Wright, E.G.

    2008-01-01

    The dogma that genetic alterations are restricted to directly irradiated cells has been challenged by observations in which effects of ionizing radiation, characteristically associated with the consequences of energy deposition in the cell nucleus, arise in non-irradiated cells. These, so called, untargeted effects are demonstrated in cells that are the descendants of irradiated cells (radiation-induced genomic instability) or in cells that have communicated with neighbouring irradiated cells (radiation-induced bystander effects). There are also reports of long-range signals in vivo, known as clastogenic factors, with the capacity to induce damage in unirradiated cells. Clastogenic factors may be related to the inflammatory responses that have been implicated in some of the pathological consequences of radiation exposures. The phenotypic expression of untargeted effects reflects a balance between the type of signals produced and the responses of cell populations to such signals, both of which may be significantly influenced by cell type and genotype. There is accumulating evidence that untargeted effects in vitro involve inter-cellular signalling, production of cytokines and free radical generation. These are also features of inflammatory responses in vivo that are known to have the potential for both bystander-mediated and persisting damage as well as for conferring a predisposition to malignancy. At present it is far from clear how untargeted effects contribute to overall cellular radiation responses and in vivo consequences but it is possible that the various untargeted effects may reflect inter-related aspects of a non-specific inflammatory-type response to radiation-induced stress and injury and be involved in a variety of the pathological consequences of radiation exposures. (orig.)

  16. Induction of chromosomal instability in human lymphoblasts by low doses of γ-radiation

    International Nuclear Information System (INIS)

    Gibbons, C.F.; Grosovsky, A.J.

    2003-01-01

    Full text: Genomic instability is a hallmark of tumorigenic progression, and a similar phenotype is also observed in a high fraction (10 - 50%) of cells that survive exposure to ionizing radiation. In both cases unstable clones are characterized by non-clonal chromosomal rearrangements, which are indicative of a high rate of genetic change during the outgrowth of an unstable parental cell. We postulate that the remarkably high frequency of radiation-induced genomic instability is incompatible with a mutational mechanism for a specific gene, or even a large family of genes. Rather, we hypothesize that a major portion of instability is attributable to the formation of chromosomal rearrangement junction sequences that act as de novo chromosomal breakage hotspots. We further suggest that critical target sequences, which represent at least 10% of the genome and include repetitive DNA sequences such as those found in centromeric heterochromatin, can be involved in breakage and rearrangement hotspots that drive persistent genomic instability and karyotypic heterogeneity. Since chromosomal damage is induced even by low dose radiation exposure, we hypothesize that this phenotype can be efficiently induced at doses that are relevant to environmental, occupational, or medical exposure. In the present study, TK6 human B-lymphoblastoid cells were irradiated with 0, 10, 20 and 200cGy, in order to provide a set of data points for single, low dose exposures. Independent clones were analyzed karyotypically approximately 40 generations after radiation exposure. Preliminary results suggest that the fraction of clones exhibiting genomic instability after 20 cGy (0.16) is similar to and statistically indistinguishable from the fraction of unstable clones following 200 cGy (0.2) exposure. These findings support the hypothesis that instability following radiation, and perhaps also in cancer, primarily reflects non-mutational mechanisms

  17. Parametric trapping of electromagnetic waves in an inhomogeneous plasma

    International Nuclear Information System (INIS)

    Silin, V.P.; Starodub, A.N.

    1977-01-01

    Considered is parametric instability in an inhomogeneous plasma at which a pumping wave is transformed to an electromagnetic wave and aperiodically in-time-growing disturbances. It is shown that after achievement of some boundary pumping value by electric field intensity an absolute parametric instability evolution becomes possible. In-time growing plasma disturbances are localized near electric field extremums of a pumping wave. Such localization areas are small as compared to characteristic size of pumping inhomogeneity in a plasma. The secondary electromagnetic waves stay within the localization areas and, therefore, are not scattered by a plasma. As following from this it has been established, that due to parametric instability electromagnetic radiation trapping by a plasma occurs. Such a trapping is considerably connected with a spatial structure of a pumping field and it cannot arise within the field of a running wave in the theoretical model considered. However parametric trapping turns out to be possible even with very small reflection coefficients

  18. Parametric instabilities in an electron beam-plasma system: magnetic field effects

    International Nuclear Information System (INIS)

    Gell, Y.; Levush, B.; Nakach, R.

    1981-09-01

    The effects of a magnetic field on the excitation of low-frequency parametric instabilities in a beam-plasma system are considered. The dispersion relation of the three-dimensional beamless configuration, is analytically evaluated for an electrostatic pump wave having a finite wave-vector parallel to the magnetic field. The results of this analysis serve as a guide to the numerical study of the stability of the involved system including the beam. As for the one-dimensional case, one finds that two low-frequency electrostatic instability branches having different growth rates may exist simultaneously. The effects of the magnetic field on these instabilities could be summarized as follows: the small growth rate instability is negligibly small when the electron gyrofrequency is about equal to the pump wave frequency. This instability is magnetic field independent for high enough values of the field. When the plasma electron Debye length is greater than the beam electron Debye length, a large growth rate instability is excited and appears to be weakly dependent on the magnetic field, while the two instability branches are quite sensitive to change of the magnetic field, when the two Debye lengths are equal. Other characteristics of this system are also discussed

  19. Parametric instability of a large-amplitude nonmonochromatic Alfvacute en wave

    International Nuclear Information System (INIS)

    Malara, F.; Velli, M.

    1996-01-01

    The parametric instability of a finite-amplitude Alfvacute en wave is studied in a one-dimensional geometry. The pump wave is an exact solution of the nonlinear magnetohydrodynamic (MHD) equations, i.e., the magnetic field perturbation has a uniform intensity and rotates in the plane perpendicular to the propagation direction, but its Fourier spectrum contains several wavelengths. The weakly nonmonochromatic regime is first studied by an analytical approach. It is shown that the growth rate of the instability decreases quadratically with a parameter that measures the departure from the monochromatic case. The fully nonmonochromatic case is studied by numerically solving the instability equations, when the phase function of the pump wave has a power-law spectrum. Though the growth rate is maximum in the monochromatic case, it remains of the same order of magnitude also for wide spectrum pump waves. For quasimonochromatic waves the correction to the growth rate depends only on the spectral index of the phase function. copyright 1996 American Institute of Physics

  20. Absolute parametric instability of low frequency waves in a 2-D nonuniform anisotropic warm plasma

    International Nuclear Information System (INIS)

    Zaki, N.G.

    2004-01-01

    Using the separation method, the problem of absolute parametric instability (API) of electrostatic waves in magnetized pumped warm plasma is investigated. In this case the effect of static strong magnetic field is considered. The problem of strong magnetic field is solved in 2-D nonuniform plane plasma. The equations which describe the spatial part of the electric potential are obtained. Also the growth rates and conditions of the parametric instability for periodic cases are obtained. It is found that the spatial nonuniformity of the plasma exerts a stabilizing effect on the API. It is shown that the growth rates of periodic and aperiodic API in warm plasma are reduced in comparison with a cold plasma case

  1. Relativistic effects in ultra-high-intensity laser-plasma interaction: electron parametric instabilities and ponderomotive force

    International Nuclear Information System (INIS)

    Quesnel, Brice

    1998-01-01

    This research thesis reports a theoretical and numeric study of the behaviour of two non linear phenomena of the laser-plasma interaction physics in a relativistic regime: the electronic parametric instabilities, and the ponderomotive force. In a first part, the author establishes the three-dimensional scattering relationship of electron parametric instabilities for a circularly polarised wave propagating in a homogeneous and cold plasma, without limitations of wave intensity, nor of plasma density. Results are verified by comparison with those of two-dimensional numerical simulations. The Weibel instability is also briefly studied in relativistic regime. In the second part, the author establishes an expression of the ponderomotive force exerted by an ultra-intense laser pulse in the vacuum about the focus point. A numerical code of integration of equations of motion of an electron in the laser field is used for the different expressions corresponding different approximation degrees. Results are used to interpret a recent experiment, and to critic other theoretical works [fr

  2. Excitation of upper-hybrid waves by a thermal parametric instability

    International Nuclear Information System (INIS)

    Lee, M.C.; Kuo, S.P.

    1983-01-01

    A purely growing instability characterized by a four-wave interaction is analysed in a uniform, magnetized plasma. Up-shifted and down-shifted upper-hybrid waves and a non-oscillatory mode can be excited by a pump wave of ordinary rather than extraordinary polarization in the case of ionospheric heating. The differential Ohmic heating force dominates over the ponderomotive force as the wave-wave coupling mechanism. The beating current at zero frequency produces a significant stabilizing effect on the excitation of short-scale modes by counterbalancing the destabilizing effect of the differential Ohmic heating. The effect of ionospheric inhomogeneity is estimated, showing a tendency to raise the thresholds of the instability. When applied to ionospheric heating experiments, the present theory can explain the excitation of field-aligned plasma lines and ionospheric irregularities with a continuous spectrum ranging from metre-scale to hundreds of metre-scale. Further, the proposed mechanism may become a competitive process to the parametric decay instability and be responsible for the overshoot phenomena of the plasma line enhancement at Arecibo. (author)

  3. The elevation of radiation load on ecosystems and genome instability of organisms

    International Nuclear Information System (INIS)

    Gaziyev, A. I.; Bezlepkin, V.Q.

    2002-01-01

    prophylaxis of human disorders. Thus, it was found that the action of low-dose ionizing radiation on living organisms might induce an adaptive repair response in them aimed at decreasing the genetic consequences of the exposure. However, the potentialities of defense and repair systems of an organism are limited, so an increase in genome lesions may cause inheritable mutations, cancer and other pathologies, and death. DNA lesions caused by ionizing radiation in small and sublethal doses can essentially be repaired, whereas unrepaired lesions and errors of repair, replication, and recombination systems lead to formation of mutational changes in DNA sequences. These changes may be transmitted to daughter cells and induce genome instability in the progeny. Induced genome instability in survived somatic cells is characterized by persistence of a high level of acquired variability in many generations of these cells. Genome instability manifests itself as an increased frequency of karyotypic anomalies, chromosome and gene mutations, clonal heterogeneity, and malignant transformation in the progeny of cells exposed to DNA-damaging agents. Besides, cells with genome instability show increased amplification of genes and changes in their expression, as well as disturbances in their differentiation, delays in reproductive death and other phenotypic characters of abnormal development. Whereas some progress has been made towards knowledge of genome instability in the somatic cells of mammals, the radiation-induced genome instability in germ cells transmitted to individuals of the next generation is still not clearly understood. At the same time, evidence has been obtained which suggests that the transmission of genome instability to the somatic cells of the progeny from the germ cells of gamma - radiation-exposed parents is possible. This conclusion is based on the data on mutation frequency in the progeny of parents exposed to DNA-damaging agents. For instance, a significant increase in

  4. Folic acid deficiency increases chromosomal instability, chromosome 21 aneuploidy and sensitivity to radiation-induced micronuclei

    International Nuclear Information System (INIS)

    Beetstra, Sasja; Thomas, Philip; Salisbury, Carolyn; Turner, Julie; Fenech, Michael

    2005-01-01

    Folic acid deficiency can lead to uracil incorporation into DNA, hypomethylation of DNA, inefficient DNA repair and increase chromosome malsegregation and breakage. Because ionising radiation increases demand for efficient DNA repair and also causes chromosome breaks we hypothesised that folic acid deficiency may increase sensitivity to radiation-induced chromosome breakage. We tested this hypothesis by using the cytokinesis-block micronucleus assay in 10 day WIL2-NS cell cultures at four different folic acid concentrations (0.2, 2, 20, and 200 nM) that span the 'normal' physiological range in humans. The study showed a significant dose-dependent increase in frequency of binucleated cells with micronuclei and/or nucleoplasmic bridges with decreasing folic acid concentration (P < 0.0001, P = 0.028, respectively). These biomarkers of chromosomal instability were also increased in cells irradiated (1.5 Gy γ-rays) on day 9 relative to un-irradiated controls (P < 0.05). Folic acid deficiency and γ-irradiation were shown to have a significant interactive effect on frequency of cells containing micronuclei (two-way ANOVA, interaction P 0.0039) such that the frequency of radiation-induced micronucleated cells (i.e. after subtracting base-line frequency of un-irradiated controls) increased with decreasing folic acid concentration (P-trend < 0.0001). Aneuploidy of chromosome 21, apoptosis and necrosis were increased by folic acid deficiency but not by ionising radiation. The results of this study show that folate status has an important impact on chromosomal stability and is an important modifying factor of cellular sensitivity to radiation-induced genome damage

  5. Genomic instability in rat: Breakpoints induced by ionising radiation and interstitial telomeric-like sequences

    International Nuclear Information System (INIS)

    Camats, Nuria; Ruiz-Herrera, Aurora; Parrilla, Juan Jose; Acien, Maribel; Paya, Pilar; Giulotto, Elena; Egozcue, Josep; Garcia, Francisca; Garcia, Montserrat

    2006-01-01

    The Norwegian rat (Rattus norvegicus) is the most widely studied experimental species in biomedical research although little is known about its chromosomal structure. The characterisation of possible unstable regions of the karyotype of this species would contribute to the better understanding of its genomic architecture. The cytogenetic effects of ionising radiation have been widely used for the study of genomic instability, and the importance of interstitial telomeric-like sequences (ITSs) in instability of the genome has also been reported in previous studies in vertebrates. In order to describe the unstable chromosomal regions of R. norvegicus, the distribution of breakpoints induced by X-irradiation and ITSs in its karyotype were analysed in this work. For the X-irradiation analysis, 52 foetuses (from 14 irradiated rats) were studied, 4803 metaphases were analysed, and a total of 456 breakpoints induced by X-rays were detected, located in 114 chromosomal bands, with 25 of them significantly affected by X-irradiation (hot spots). For the analysis of ITSs, three foetuses (from three rats) were studied, 305 metaphases were analysed and 121 ITSs were detected, widely distributed in the karyotype of this species. Seventy-six percent of all hot spots analysed in this study were co-localised with ITSs

  6. Genomic instability in rat: Breakpoints induced by ionising radiation and interstitial telomeric-like sequences

    Energy Technology Data Exchange (ETDEWEB)

    Camats, Nuria [Institut de Biotecnologia i Biomedicina (IBB), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Departament de Biologia Cel.lular, Fisiologia i Immunologia Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Ruiz-Herrera, Aurora [Departament de Biologia Cel.lular, Fisiologia i Immunologia Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Parrilla, Juan Jose [Servicio de Ginecologia y Obstetricia, Hospital Universitario Virgen de la Arrixaca, Ctra, Madrid-Cartagena, s/n, El Palmar, 30120 Murcia (Spain); Acien, Maribel [Servicio de Ginecologia y Obstetricia, Hospital Universitario Virgen de la Arrixaca, Ctra, Madrid-Cartagena, s/n, El Palmar, 30120 Murcia (Spain); Paya, Pilar [Servicio de Ginecologia y Obstetricia, Hospital Universitario Virgen de la Arrixaca, Ctra, Madrid-Cartagena, s/n, El Palmar, 30120 Murcia (Spain); Giulotto, Elena [Dipartimento di Genetica e Microbiologia Adriano Buzzati Traverso, Universita degli Studi di Pavia, 27100 Pavia (Italy); Egozcue, Josep [Departament de Biologia Cel.lular, Fisiologia i Immunologia Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Garcia, Francisca [Institut de Biotecnologia i Biomedicina (IBB), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain); Garcia, Montserrat [Institut de Biotecnologia i Biomedicina (IBB), Universitat Autonoma de Barcelona, 08193 Barcelona (Spain) and Departament de Biologia Cellular, Fisiologia i Immunologia Universitat Autonoma de Barcelona, 08193 Barcelona (Spain)]. E-mail: Montserrat.Garcia.Caldes@uab.es

    2006-03-20

    The Norwegian rat (Rattus norvegicus) is the most widely studied experimental species in biomedical research although little is known about its chromosomal structure. The characterisation of possible unstable regions of the karyotype of this species would contribute to the better understanding of its genomic architecture. The cytogenetic effects of ionising radiation have been widely used for the study of genomic instability, and the importance of interstitial telomeric-like sequences (ITSs) in instability of the genome has also been reported in previous studies in vertebrates. In order to describe the unstable chromosomal regions of R. norvegicus, the distribution of breakpoints induced by X-irradiation and ITSs in its karyotype were analysed in this work. For the X-irradiation analysis, 52 foetuses (from 14 irradiated rats) were studied, 4803 metaphases were analysed, and a total of 456 breakpoints induced by X-rays were detected, located in 114 chromosomal bands, with 25 of them significantly affected by X-irradiation (hot spots). For the analysis of ITSs, three foetuses (from three rats) were studied, 305 metaphases were analysed and 121 ITSs were detected, widely distributed in the karyotype of this species. Seventy-six percent of all hot spots analysed in this study were co-localised with ITSs.

  7. Genomic instability following irradiation

    International Nuclear Information System (INIS)

    Hacker-Klom, U.B.; Goehde, W.

    2001-01-01

    Ionising irradiation may induce genomic instability. The broad spectrum of stress reactions in eukaryontic cells to irradiation complicates the discovery of cellular targets and pathways inducing genomic instability. Irradiation may initiate genomic instability by deletion of genes controlling stability, by induction of genes stimulating instability and/or by activating endogeneous cellular viruses. Alternatively or additionally it is discussed that the initiation of genomic instability may be a consequence of radiation or other agents independently of DNA damage implying non nuclear targets, e.g. signal cascades. As a further mechanism possibly involved our own results may suggest radiation-induced changes in chromatin structure. Once initiated the process of genomic instability probably is perpetuated by endogeneous processes necessary for proliferation. Genomic instability may be a cause or a consequence of the neoplastic phenotype. As a conclusion from the data available up to now a new interpretation of low level radiation effects for radiation protection and in radiotherapy appears useful. The detection of the molecular mechanisms of genomic instability will be important in this context and may contribute to a better understanding of phenomenons occurring at low doses <10 cSv which are not well understood up to now. (orig.)

  8. Electromagnetic theory of the radiative Pierce instability

    International Nuclear Information System (INIS)

    Klochkov, D.N.; Rukhadze, A.A.

    1997-01-01

    A study is made of the radiative Pierce instability of a relativistic electron beam propagating in a waveguide in the presence of an infinitely strong magnetic field. The perturbation theory is used to find the growth rates and conditions of instability over a broad range of the beam current. It is shown that, under the Pierce boundary conditions, the instability is Raman in nature, and there is no current threshold for the instability. This allows the instability saturation level to be accurately determined from the condition for the violation of the Cherenkov resonance and the radiation efficiency to be estimated

  9. Electromagnetic theory of the radiative Pierce instability

    International Nuclear Information System (INIS)

    Klochkov, D.N.; Rukhadze, A.A.

    1997-01-01

    The radiative Pierce instability of a relativistic electron beam in a waveguide stabilized by an infinite strong magnetic field is considered. the increment and conditions for instability development in a wide interval of the beam currents are determined on the basis of the perturbation theory. It is shown that the instability has always the Raman character and is threshold less in current for the Pierce boundary conditions. It permits sufficiently strictly to define the instability saturation level from breaking the resonance condition and to estimate the radiation efficiency

  10. Comparison of the coherent radiation-induced microbunching instability in a free-electron laser and a magnetic chicane

    Directory of Open Access Journals (Sweden)

    S. Reiche

    2003-04-01

    Full Text Available A self-amplified spontaneous emission free-electron laser (SASE FEL is a device which is based on the creation of a very intense, relativistic electron beam which has very little temperature in all three phase planes. The beam in this system is described as having “high brightness,” and when it is bent repetitively in a magnetic undulator, undergoes a radiation-mediated microbunching instability. This instability can amplify the original radiation amplitude at a particular, resonant wavelength by many orders of magnitude. In order to obtain high brightness beams, it is necessary to compress them to obtain higher currents than available from the electron source. Compression is accomplished by the use of magnetic chicanes, which are quite similar to, if much longer than, a single period of the undulator. It should not be surprising that such chicanes also support a radiation-mediated microbunching interaction, which has recently been investigated, and has been termed coherent synchrotron radiation (CSR instability. The purpose of this paper is to compare and contrast the characteristics of the closely related FEL and CSR microbunching instabilities. We show that a high-gain regime of the CSR instability exists which is formally similar to the FEL instability.

  11. An update on the mechanisms and pathophysiological consequences of genomic instability with a focus on ionizing radiation

    Directory of Open Access Journals (Sweden)

    Streffer C

    2015-12-01

    Full Text Available Christian Streffer Institute for Medical Radiobiology, University Clinics Essen, Essen, Germany Abstract: The genome of eukaryotic cells is generally instable. DNA damage occurs by endogenous processes and exogenous toxic agents. The efficient DNA repair pathways conserve the genetic information to a large extent throughout the life. However, exposure to genotoxic agents can increase the genomic instability. This phenomenon develops in a delayed manner after approximately 20 and more cell generations. It is comparatively thoroughly investigated after the exposure to ionizing radiation. The increase of genomic instability has been observed after exposures to ionizing radiation in vitro and in vivo as well as with many different types of radiation. The effect is induced over a wide dose range, and it has been found with cell death, chromosomal damage, cell transformations, mutations, double-strand breaks, malformations, and cancers. No specific chromosomes or genomic sites have been observed for such events. The increased genomic instability can be transmitted to the next generation. Possible mechanisms such as oxidative stress (mitochondria may be involved, reduced DNA repair, changes in telomeres, epigenetic effects are discussed. A second wave of oxidative stress has been observed after radiation exposures with considerably high doses as well as with cytotoxic agents at time periods when an increased genomic instability was seen. However, the increase of genomic instability also happens to much lower radiation doses. Hypoxia induces an increase of genomic instability. This effect is apparently connected with a reduction of DNA repair. Changes of telomeres appear as the most probable mechanisms for the increase of genomic instability. Syndromes have been described with a genetic predisposition for high radiosensitivity. These individuals show an increase of cancer, a deficient DNA repair, a disturbed regulation of the cell cycle, and an

  12. Thresholds of parametric instabilities near the lower hybrid frequency

    International Nuclear Information System (INIS)

    Berger, R.L.; Perkins, F.W.

    1975-06-01

    Resonant decay instabilities of a pump wave with frequency ω 0 near the lower-hybrid frequency ω/sub LH/ are analyzed with respect to the wavenumber k of the decay waves and the ratio ω 0 /ω/sub LH/ to determine the decay process with the minimum threshold. It was found that the lowest thresholds are for decay into an electron plasma (lower hybrid) wave plus either a backward ion-cyclotron wave, an ion Bernstein wave, or a low frequency sound wave. For ω 0 less than (2ω/sub LH/)/sup 1 / 2 /, it was found that these decay processes can occur and have faster growth than ion quasimodes provided the drift velocity (cE 0 /B 0 ) is much less than the sound speed. In many cases of interest, electromagnetic corrections to the lower-hybrid wave rule out decay into all but short wavelength (k rho/sub i/ greater than 1) waves. The experimental results are consistent with the linear theory of parametric instabilities in a homogeneous plasma. (U.S.)

  13. Parametric Cherenkov radiation (development of idea)

    International Nuclear Information System (INIS)

    Buts, V.A.

    2004-01-01

    Some physical results of researches about charged particles radiation in mediums with a periodic heterogeneity and in periodic potential are reported. The development of ideas Parametric Cherenkov Radiation has shown, that in mediums, which have even a weak degree of a periodic heterogeneity of an permittivity or potential, the nonrelativistic oscillators can radiated as relativistic. They effectively radiate the high numbers of harmonics. In particular, in the carried out experiments the ultra-violet radiation was excited at action on a crystal of intensive ten-centimetric radiation. These results give the reasons to hope for making of nonrelativistic lasers on free electrons

  14. Fine features of parametric X-ray radiation by relativistic electrons and ions

    Directory of Open Access Journals (Sweden)

    K.B. Korotchenko

    2017-11-01

    Full Text Available In present work within the frame of dynamic theory for parametric X-ray radiation in two-beam approximation we have presented detailed studies on parametric radiation emitted by relativistic both electrons and ions at channeling in crystals that is highly requested at planned experiments. The analysis done has shown that the intensity of radiation at relativistic electron channeling in Si (110 with respect to the conventional parametric radiation intensity has up to 5% uncertainty, while the error of approximate formulas for calculating parametric X-ray radiation maxima does not exceed 1.2%. We have demonstrated that simple expressions for the Fourier components of Si crystal susceptibility χ0 and χgσ could be reduced, as well as the temperature dependence for radiation maxima in Si crystal (diffraction plane (110 within Debye model. Moreover, for any types of channeled ions it is shown that the parametric X-ray radiation intensity is proportional to z2−b(Z,z/z with the function b(Z,z depending on the screening parameter and the ion charge number z=Z−Ze.

  15. Chromosomal instability can be induced by the formation of breakage-prone chromosome rearrangement junctions

    International Nuclear Information System (INIS)

    Allen, R.N.; Ritter, L.; Moore, S.R.; Grosovsky, A.J.

    2003-01-01

    Full text: Studies in our lab have led to the hypothesis that chromosomal rearrangements can generate novel breakage-prone sites, resulting in chromosomal instability acting predominantly in cis. For example, specific breakage of large blocks of centromeric region heterochromatin on chromosome 16q by treatment with 2,6-diaminopurine (DAP) is associated with repeated rearrangement of chromosome 16q during outgrowth of DAP-treated clones, thereby establishing a link between the initial site of damage and the occurrence of persistent chromosomal instability. Similarly, karyotypic analysis of gamma ray induced instability demonstrated that chromosomal rearrangements in sub-clones were significantly clustered near the site of previously identified chromosomal rearrangement junctions in unstable parental clones. This study investigates the hypothesis that integration of transfected sequences into host chromosomes could create breakage-prone junction regions and persistent genomic instability without exposure to DNA-damage agents. These junctions may mimic the unstable chromosomal rearrangements induced by DAP or radiation, and thus provide a test of the broader hypothesis that instability can to some extent be attributed to the formation of novel chromosomal breakage hot spots. These experiments were performed using human-hamster hybrid AL cells containing a single human chromosome 11, which was used to monitor instability in a chromosomal painting assay. AL cells were transfected with a 2.5 Kb fragment containing multiple copies of the 180 bp human alpha heterochromatic repeat, which resulted in chromosomal instability in 41% of the transfected clones. Parallel exposure to gamma-radiation resulted in a similar level of chromosomal instability, although control transfections with plasmid alone did not lead to karyotypic instability. Chromosomal instability induced by integration of alpha heterochromatic repeats was also frequently associated with delayed reproductive

  16. Impact of the Wiggler Coherent Synchrotron Radiation Impedance on the Beam Instability

    International Nuclear Information System (INIS)

    Wu, Juhao

    2003-01-01

    Coherent Synchrotron Radiation (CSR) can play an important role by not only increasing the energy spread and emittance of a beam, but also leading to a potential instability. Previous studies of the CSR induced longitudinal instability were carried out for the CSR impedance due to dipole magnets. However, many storage rings include long wigglers where a large fraction of the synchrotron radiation is emitted. This includes high-luminosity factories such as DAPHNE, PEP-II, KEK-B, and CESR-C as well as the damping rings of future linear colliders. In this paper, the instability due to the CSR impedance from a wiggler is studied assuming a large wiggler parameter K. The primary consideration is a low frequency microwave-like instability, which arises near the pipe cut-off frequency. Detailed results are presented on the growth rate and threshold for the damping rings of several linear collider designs. Finally, the optimization of the relative fraction of damping due to the wiggler systems is discussed for the damping rings

  17. Electromagnetic radiation from beam-plasma instabilities

    International Nuclear Information System (INIS)

    Stenzel, R.L.; Whelan, D.A.

    1982-01-01

    This chapter investigates the mechanism by which unstable electrostatic waves of an electron-beam plasma system are converted into observed electromagnetic waves. Electromagnetic radiation arises from both natural beam-plasma systems (e.g., type III solar bursts and kilometric radiation), and from man-made electron beams injected from rockets and spacecraft. A pulsed magnetized discharge plasma is produced with a 1 m diam. oxide-coated cathode and the discussed experiment is performed in the quiescent afterglow. The primary beam-plasma instability involves the excitation of electrostatic plasma waves. Electromagnetic radiation from the beam-plasma system is observed with microwave antennas outside the plasma (all probes removed) or with coax-fed dipoles which can be inserted radially and axially into the plasma. The physical process of mode coupling by which electromagnetic radiation is generated in an electrostatic beam-plasma instability is identified. The results are relevant to beam injection experiments from rockets or satellites into space plasmas. The limited penetration of the beam current into the plasma due to instabilities is demonstrated

  18. Non-homologous end-joining genes are not inactivated in human radiation-induced sarcomas with genomic instability

    International Nuclear Information System (INIS)

    Lefevre, S.H.; Coquelle, A.; Gonin-Laurent, N.

    2005-01-01

    DNA double-strand break (DSB) repair pathways are implicated in the maintenance of genomic stability. However the alterations of these pathways, as may occur in human tumor cells with strong genomic instability, remain poorly characterized. We analyzed the loss of heterozygosity (LOH) and the presence of mutations for a series of genes implicated in DSB repair by non-homologous end-joining in five radiation-induced sarcomas devoid of both active Tp53 and Rb1. LOH was recurrently observed for 8 of the 9 studied genes (KU70, KU80, XRCC4, LIG4, Artemis, MRE11, RAD50, NBS1) but not for DNA-PKcs. No mutation was found in the remaining allele of the genes with LOH and the mRNA expression did not correlate with the allelic status. Our findings suggest that non-homologous end-joining repair pathway alteration is unlikely to be involved in the high genomic instability observed in these tumors. (author)

  19. Observation of parametric X-ray radiation by an imaging plate

    International Nuclear Information System (INIS)

    Takabayashi, Y.; Shchagin, A.V.

    2012-01-01

    We have demonstrated experimentally the application of an imaging plate for registering the angular distribution of parametric X-ray radiation. The imaging plate was used as a two-dimensional position-sensitive X-ray detector. High-quality images of the fine structure in the angular distributions of the yield around the reflection of the parametric X-ray radiation produced in a silicon crystal by a 255-MeV electron beam from a linear accelerator have been observed in the Laue geometry. A fairly good agreement between results of measurements and calculations by the kinematic theory of parametric X-ray radiation is shown. Applications of the imaging plates for the observation of the angular distribution of X-rays produced by accelerated particles in a crystal are also discussed.

  20. Radiation loss driven instabilities in laser heated plasmas

    International Nuclear Information System (INIS)

    Evans, R.G.

    1985-01-01

    Any plasma in which a significant part of the power balance is due to optically thin radiative losses may be subject to a radiation cooling instability. A simple analytical model gives the dispersion relation for the instability and inclusion of a realistic radiation loss term in a two dimensional hydrodynamic simulation shows that ''jet'' like features form in moderate to high Z plasmas

  1. Spin effect on parametric interactions of waves in magnetoplasmas

    International Nuclear Information System (INIS)

    Shahid, M.; Melrose, D. B.; Jamil, M.; Murtaza, G.

    2012-01-01

    The parametric decay instability of upper hybrid wave into low-frequency electromagnetic Shear Alfvén wave and Ordinary mode radiation (O-mode) has been investigated in an electron-ion plasma immersed in the uniform external magnetic field. Incorporating quantum effect due to electron spin, the fluid model has been used to investigate the linear and nonlinear response of the plasma species for three-wave coupling in a magnetoplasma. It is shown that the spin of electrons has considerable effect on the parametric decay of upper hybrid wave into Ordinary mode radiation (O-mode) and Shear Alfvén wave even in classical regime.

  2. Parametrically induced low-frequency waves in weakly inhomogeneous magnetized plasmas

    International Nuclear Information System (INIS)

    Pesic, S.

    1981-01-01

    The linear dispersion relation governing the parametric interaction of a lower hybrid pump wave with a weakly-inhomogeneous current carrying hot plasma confined by a helical magnetic field is derived and solved numerically. The stability boundaries are delineated over a wide range in the k-space. The frequency and growth rate of decay instabilities are calculated for plasma parameters relevant to lower hybrid plasma heating experiments. The parametric excitation of drift waves and ion cyclotron current instabilities is discussed. In the low-density plasma region low minimum thresholds and high growth rates are obtained for the pump decay into ion cyclotron and nonresonant quasimodes. The spatial amplification of hot ion Bernstein waves and nonresonant quasimodes dominate in the plasma core (ω 0 /ωsub(LH) < 2). The presented theoretical results are in qualitative agreement with current LH plasma heating experiments. (author)

  3. Single-mode coherent synchrotron radiation instability

    Directory of Open Access Journals (Sweden)

    S. Heifets

    2003-06-01

    Full Text Available The microwave instability driven by the coherent synchrotron radiation (CSR has been previously studied [S. Heifets and G. V. Stupakov, Phys. Rev. ST Accel. Beams 5, 054402 (2002] neglecting effect of the shielding caused by the finite beam pipe aperture. In practice, the unstable mode can be close to the shielding threshold where the spectrum of the radiation in a toroidal beam pipe is discrete. In this paper, the CSR instability is studied in the case when it is driven by a single synchronous mode. A system of equations for the beam-wave interaction is derived and its similarity to the 1D free-electron laser theory is demonstrated. In the linear regime, the growth rate of the instability is obtained and a transition to the case of continuous spectrum is discussed. The nonlinear evolution of the single-mode instability, both with and without synchrotron damping and quantum diffusion, is also studied.

  4. Radiation-induced genomic instability is associated with DNA methylation changes in cultured human keratinocytes

    International Nuclear Information System (INIS)

    Kaup, Sahana; Grandjean, Valerie; Mukherjee, Rajarshi; Kapoor, Aparna; Keyes, Edward; Seymour, Colin B.; Mothersill, Carmel E.; Schofield, Paul N.

    2006-01-01

    The mechanism by which radiation-induced genomic instability is initiated, propagated and effected is currently under intense scrutiny. We have investigated the potential role of altered genomic methylation patterns in the cellular response to irradiation and have found evidence for widespread dysregulation of CpG methylation persisting up to 20 population doublings post-irradiation. Similar effects are seen with cells treated with medium from irradiated cells (the 'bystander effect') rather than subjected to direct irradiation. Using an arbitrarily primed methylation sensitive PCR screening method we have demonstrated that irradiation causes reproducible alterations in the methylation profile of a human keratinocyte cell line, HPV-G, and have further characterised one of these sequences as being a member of a retrotransposon element derived sequence family on chromosome 7; MLT1A. Multiple changes were also detected in the screen, which indicate that although the response of cells is predominantly hypermethylation, specific hypomethylation occurs as well. Sequence specific changes are also reported in the methylation of the pericentromeric SAT2 satellite sequence. This is the first demonstration that irradiation results in the induction of heritable methylation changes in mammalian cells, and provides a link between the various non-radiological instigators of genomic instability, the perpetuation of the unstable state and several of its manifestations

  5. Electromagnetic radiation by parametric decay of upper hybrid waves in ionospheric modification experiments

    International Nuclear Information System (INIS)

    Leyser, T.B.

    1994-01-01

    A nonlinear dispersion relation for the parametric decay of an electrostatic upper hybrid wave into an ordinary mode electromagnetic wave, propagating parallel to the ambient magnetic field, and an electrostatic low frequency wave, being either a lower hybrid wave or a high harmonic ion Bernstein wave, is derived. The coherent and resonant wave interaction is considered to take place in a weakly magnetized and collisionless Vlasov plasma. The instability growth rate is computed for parameter values typical of ionospheric modification experiments, in which a powerful high frequency electromagnetic pump wave is injected into the ionospheric F-region from ground-based transmitters. The electromagnetic radiation which is excited by the decaying upper hybrid wave is found to be consistent with the prominent and commonly observed downshifted maximum (DM) emission in the spectrum of stimulated electromagnetic emission

  6. Curvature-Induced Instabilities of Shells

    Science.gov (United States)

    Pezzulla, Matteo; Stoop, Norbert; Steranka, Mark P.; Bade, Abdikhalaq J.; Holmes, Douglas P.

    2018-01-01

    Induced by proteins within the cell membrane or by differential growth, heating, or swelling, spontaneous curvatures can drastically affect the morphology of thin bodies and induce mechanical instabilities. Yet, the interaction of spontaneous curvature and geometric frustration in curved shells remains poorly understood. Via a combination of precision experiments on elastomeric spherical shells, simulations, and theory, we show how a spontaneous curvature induces a rotational symmetry-breaking buckling as well as a snapping instability reminiscent of the Venus fly trap closure mechanism. The instabilities, and their dependence on geometry, are rationalized by reducing the spontaneous curvature to an effective mechanical load. This formulation reveals a combined pressurelike term in the bulk and a torquelike term in the boundary, allowing scaling predictions for the instabilities that are in excellent agreement with experiments and simulations. Moreover, the effective pressure analogy suggests a curvature-induced subcritical buckling in closed shells. We determine the critical buckling curvature via a linear stability analysis that accounts for the combination of residual membrane and bending stresses. The prominent role of geometry in our findings suggests the applicability of the results over a wide range of scales.

  7. Dissipative-drift wave instability in the presence of impurity radiation

    International Nuclear Information System (INIS)

    Bharuthram, R.; Shukla, P.K.

    1992-01-01

    It is believed that electrostatic fluctuations in edge plasmas are usually triggered by micro and macroscopic plasma instabilities. The latter involve dissipative-drift waves as well as tearing and rippling modes in nonuniform plasmas. However, if the plasma edge contains impurity radiation, then the radiative condensation instability could be the cause of nonthermal fluctuations. The radiative condensation instabilities have been extensively investigated in a homogeneous plasma by many authors. The effect of equilibrium density and electron temperature inhomogeneities in the study of radiative condensation instabilities has been examined by Shukla and Yu. They found new drift-like modes driven by the combined effect of impurity radiation loss and the equilibrium density and temperature gradients. The analyses of Shukla and Yu is, however, limited to low-frequency, long wavelength collisionless drift waves. Since the edge plasma of toroidal devices is highly collisional, the results of collisionless theories cannot be directly applied to explain the origin of nonthermal fluctuations. In this paper, we study the influence of impurity radiation on the dissipative-drift wave instability in a collision-dominated nonuniform plasma embedded in a homogeneous magnetic field. (author) 6 refs

  8. Delayed chromosomal instability induced by DNA damage

    International Nuclear Information System (INIS)

    Morgan, W.F.; Marder, B.A.; Day, J.P.

    1994-01-01

    Cellular exposure to DNA damaging agents rapidly results in a dose dependent increase in chromosomal breakage and gross structural chromosomal rearrangements. Over recent years, evidence has been accumulating indicating genomic instability can manifest multiple generations after cellular exposure to physical and chemical DNA damaging agents. Genomic instability manifests in the progeny of surviving cells, and has been implicated in mutation, gene application, cellular transformation, and cell killing. To investigate chromosome instability following DNA damage, we have used fluorescence in situ hybridization to detect chromosomal rearrangements in a human/hamster somatic hybrid cell line following exposure to ionizing radiation. Delayed chromosomal instability was detected when multiple populations of uniquely arranged metaphases were observed in clonal isolates raised from single cells surviving X-irradiation many generations after exposure. At higher radiation doses, chromosomal instability was observed in a relatively high frequency of surviving clones and, in general, those clones showed delayed chromosome instability also showed reduced survival as measured by colony forming ability

  9. Effects of warmness and spatial nonuniformity of plasma waveguide on periodic absolute parametric instability

    International Nuclear Information System (INIS)

    Zaki, N.G.; Bekheit, A.H.

    2011-01-01

    The periodic absolute parametric instability (API) of the low-frequency oscillations excited by a monochromatic pumping field of an arbitrary amplitude in a warm 1-D (one-dimensional) nonuniform magnetoactive plasma is investigated. The separation method can be used for solving the two-fluid plasma equations describing the system. By applying this method we were able to determine the frequencies and growth rates of unstable modes and the self-consistent electric field. Plasma electrons are considered to have a thermal velocity. Different solutions for the spatial equation can be obtained the following cases: A) API in a uniform plasma, B) API in a nonuniform plasma. The latter has been studied here for two cases: B.1) the exact harmonic oscillator and B.2) the bounded harmonic oscillator (a bounded plasma). An increment has been found in the build-up of the oscillations, and it has been shown that the spatial nonuniformity of the plasma exerts the stabilizing effect on the parametric instability. A reduced growth rate of API in the warm plasma, in comparison to the cold plasma, is reported. It has also been found that the warmness of the plasma has no effect on the solution of the space part of the problem (only through the separation constant). (authors)

  10. Whirling modes and parametric instabilities in the discrete Sine-Gordon equation: Experimental tests in Josephson rings

    International Nuclear Information System (INIS)

    Watanabe, S.; Strogatz, S.H.; van der Zant, H.S.J.; Orlando, T.P.

    1995-01-01

    We analyze the damped driven discrete sine-Gordon equation. For underdamped, highly discrete systems, we show that whirling periodic solutions undergo parametric instabilities at certain drive strengths. The theory predicts novel resonant steps in the current-voltage characteristics of discrete Josephson rings, occurring in the return path of the subgap region. We have observed these steps experimentally in a ring of 8 underdamped junctions. An unusual prediction, verified experimentally, is that such steps occur even if there are no vortices in the ring. Numerical simulations indicate that complex spatiotemporal behavior occurs past the onset of instability

  11. Computer modelling of radiation-induced bystander effect

    International Nuclear Information System (INIS)

    Khvostunov, Igor K.; Nikjoo, Hooshang

    2002-01-01

    Radiation-induced genomic instability and bystander effects are now well established consequences of exposure of living cells to ionising radiation. It has been observed that cells not directly hit by radiation tracks may still exhibit radiation effects. We present a quantitative modelling of the radiation-induced bystander effect based on a diffusion model of spreading the bystander signal. The model assumes the bystander factor to be a protein of low molecular weight, given out by the hit cell, diffusing in the medium and reacting with non-hit cells. The model calculations successfully predict the results of cell survival in an irradiated conditioned medium. The model predicts the shape of dose-effect relationship for cell survival and oncogenic transformation induced by broad-beam and micro-beam irradiation by alpha-particles. (author)

  12. Effects of Warmness and Spatial Nonuniformity of the Plasma Waveguide on Periodic Absolute Parametric Instability

    International Nuclear Information System (INIS)

    Zaki, N.G.; Bekheit, A.H.

    2011-01-01

    The periodic absolute parametric instability (API) of the low-frequency oscillations excited by a monochromatic pumping field of arbitrary amplitude in a warm I-D nonuniform magneto active plasma is investigated. One can use the separation method to solve the two-fluid plasma equations which describe the system. The method used enables us to determine the frequencies and growth rates of unstable modes and the self-consistent electric field. Plasma electrons are considered to have a thermal velocity. One can examine different solutions for the spatial equation in the following cases: A) API in uniform Plasma B) API in nonuniform plasma, we study this case for two variants: B.1) Exact harmonic oscillator and B.2) Bounded harmonic oscillator (bounded plasma). Increment is found in the buildup of the oscillations, and it is shown that the spatial nonuniformity of the plasma exerts a stabilizing effect on the parametric instability. It is shown that the growth rate of API in warm plasma is reduced compared to cold plasma. It is found also that the warmness of the plasma has no effect on the solution of the space part of the problem ( only through the separation constant )

  13. Current-driven parametric resonance in magnetic multilayers

    International Nuclear Information System (INIS)

    Wang, C; Seinige, H; Tsoi, M

    2013-01-01

    Current-induced parametric excitations were observed in point-contact spin-valve nanodevices. Point contacts were used to inject high densities of direct and microwave currents into spin valves, thus producing oscillating spin-transfer and Oersted-field torques on magnetic moments. The resulting magnetodynamics were observed electrically by measuring rectified voltage signals across the contact. In addition to the spin-torque-driven ferromagnetic resonance we observe doubled-frequency signals which correspond to the parametric excitation of magnetic moments. Numerical simulations suggest that while both spin-transfer torque and ac Oersted field contribute to the parametrically excited dynamics, the ac spin torque dominates, and dc spin torque can switch it on and off. The dc bias dependence of the parametric resonance signal enabled the mapping of instability regions characterizing the nonlinearity of the oscillation. (paper)

  14. Nonthermal Radiation Processes in Interplanetary Plasmas

    Science.gov (United States)

    Chian, A. C. L.

    1990-11-01

    amplitude to exceed the thresfiold conditions, nonlinear mode conversion electromagnetic waves can be effected through parametric instabilities. A number of electromagnetic parametric instabilities driven by intense Langmuir waves can be excited in a plasma: (1) electromagnetic decay/fusion instabilities driven by a traveling Langmuir pump; (2) double electromagnetic decay/fusion instabilities driven by two oppositely directed Langmuir pumps; and (3) electromagnetic oscillating two-stream instabilities driven by two counterstreaming Langmuir pumps. It is concluded that the electromagnetic parametric instabilities induced by Langmuir waves are likely sources of nonthermal radiations in interplanetary plasmas. Keq ( : INTERPLANETARY MEDIUM - PLASMAS

  15. RADIATIVE RAYLEIGH-TAYLOR INSTABILITIES

    International Nuclear Information System (INIS)

    Jacquet, Emmanuel; Krumholz, Mark R.

    2011-01-01

    We perform analytic linear stability analyses of an interface separating two stratified media threaded by a radiation flux, a configuration relevant in several astrophysical contexts. We develop a general framework for analyzing such systems and obtain exact stability conditions in several limiting cases. In the optically thin, isothermal regime, where the discontinuity is chemical in nature (e.g., at the boundary of a radiation pressure-driven H II region), radiation acts as part of an effective gravitational field, and instability arises if the effective gravity per unit volume toward the interface overcomes that away from it. In the optically thick a diabaticregime where the total (gas plus radiation) specific entropy of a Lagrangian fluid element is conserved, for example at the edge of radiation pressure-driven bubble around a young massive star, we show that radiation acts like a modified equation of state and derive a generalized version of the classical Rayleigh-Taylor stability condition.

  16. Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation?

    Science.gov (United States)

    Morgan, William F.

    2003-01-01

    A number of nontargeted and delayed effects associated with radiation exposure have now been described. These include radiation-induced genomic instability, death-inducing and bystander effects, clastogenic factors and transgenerational effects. It is unlikely that these nontargeted effects are directly induced by cellular irradiation. Instead, it is proposed that some as yet to be identified secreted factor can be produced by irradiated cells that can stimulate effects in nonirradiated cells (death-inducing and bystander effects, clastogenic factors) and perpetuate genomic instability in the clonally expanded progeny of an irradiated cell. The proposed factor must be soluble and capable of being transported between cells by cell-to-cell gap junction communication channels. Furthermore, it must have the potential to stimulate cellular cytokines and/or reactive oxygen species. While it is difficult to imagine a role for such a secreted factor in contributing to transgenerational effects, the other nontargeted effects of radiation may all share a common mechanism.

  17. Genomic instability and radiation risk in molecular pathways to colon cancer.

    Directory of Open Access Journals (Sweden)

    Jan Christian Kaiser

    Full Text Available Colon cancer is caused by multiple genomic alterations which lead to genomic instability (GI. GI appears in molecular pathways of microsatellite instability (MSI and chromosomal instability (CIN with clinically observed case shares of about 15-20% and 80-85%. Radiation enhances the colon cancer risk by inducing GI, but little is known about different outcomes for MSI and CIN. Computer-based modelling can facilitate the understanding of the phenomena named above. Comprehensive biological models, which combine the two main molecular pathways to colon cancer, are fitted to incidence data of Japanese a-bomb survivors. The preferred model is selected according to statistical criteria and biological plausibility. Imprints of cell-based processes in the succession from adenoma to carcinoma are identified by the model from age dependences and secular trends of the incidence data. Model parameters show remarkable compliance with mutation rates and growth rates for adenoma, which has been reported over the last fifteen years. Model results suggest that CIN begins during fission of intestinal crypts. Chromosomal aberrations are generated at a markedly elevated rate which favors the accelerated growth of premalignant adenoma. Possibly driven by a trend of Westernization in the Japanese diet, incidence rates for the CIN pathway increased notably in subsequent birth cohorts, whereas rates pertaining to MSI remained constant. An imbalance between number of CIN and MSI cases began to emerge in the 1980s, whereas in previous decades the number of cases was almost equal. The CIN pathway exhibits a strong radio-sensitivity, probably more intensive in men. Among young birth cohorts of both sexes the excess absolute radiation risk related to CIN is larger by an order of magnitude compared to the MSI-related risk. Observance of pathway-specific risks improves the determination of the probability of causation for radiation-induced colon cancer in individual patients

  18. Comparison of radiation parametrizations within the HARMONIE-AROME NWP model

    Science.gov (United States)

    Rontu, Laura; Lindfors, Anders V.

    2018-05-01

    Downwelling shortwave radiation at the surface (SWDS, global solar radiation flux), given by three different parametrization schemes, was compared to observations in the HARMONIE-AROME numerical weather prediction (NWP) model experiments over Finland in spring 2017. Simulated fluxes agreed well with each other and with the observations in the clear-sky cases. In the cloudy-sky conditions, all schemes tended to underestimate SWDS at the daily level, as compared to the measurements. Large local and temporal differences between the model results and observations were seen, related to the variations and uncertainty of the predicted cloud properties. The results suggest a possibility to benefit from the use of different radiative transfer parametrizations in a NWP model to obtain perturbations for the fine-resolution ensemble prediction systems. In addition, we recommend usage of the global radiation observations for the standard validation of the NWP models.

  19. The Influence of Trapped Particles on the Parametric Decay Instability of Near-Acoustic Waves

    Science.gov (United States)

    Affolter, M.; Anderegg, F.; Dubin, D. H. E.; Driscoll, C. F.

    2017-10-01

    We present quantitative measurements of a decay instability to lower frequencies of near-acoustic waves. These experiments are conducted on pure ion plasmas confined in a cylindrical Penning-Malmberg trap. The axisymmetric, standing plasma waves have near-acoustic dispersion, discretized by the axial wave number kz =mz(π /Lp) . The nonlinear coupling rates are measured between large amplitude mz = 2 (pump) waves and small amplitude mz = 1 (daughter) waves, which have a small frequency detuning Δω = 2ω1 -ω2 . Classical 3-wave parametric coupling rates are proportional to pump wave amplitude as Γ (δn2 /n0) , with oscillatory energy exchange for Γ Δω / 2 . Experiments on cold plasmas agree quantitatively for oscillatory energy exchange, and agree within a factor-of-two for decay instability rates. However, nascent theory suggest that this latter agreement is merely fortuitous, and that the instability mechanism is trapped particles. Experiments at higher temperatures show that trapped particles reduce the instability threshold below classical 3-wave theory predictions. Supported by NSF Grant PHY-1414570, and DOE Grants DE-SC0002451 and DE-SC0008693. M. Affolter is supported by the DOE FES Postdoctoral Research Program administered by ORISE for the DOE. ORISE is managed by ORAU under DOE Contract Number DE-SC0014664.

  20. Parametric studies on automotive radiators

    International Nuclear Information System (INIS)

    Oliet, C.; Oliva, A.; Castro, J.; Perez-Segarra, C.D.

    2007-01-01

    This paper presents a set of parametric studies performed on automotive radiators by means of a detailed rating and design heat exchanger model developed by the authors. This numerical tool has been previously verified and validated using a wide experimental data bank. A first part of the analysis focuses on the influence of working conditions on both fluids (mass flows, inlet temperatures) and the impact of the selected coolant fluid. Following these studies, the influence of some geometrical parameters is analysed (fin pitch, louver angle) as well as the importance of coolant flow lay-out on the radiator global performance. This work provides an overall behaviour report of automobile radiators working at usual range of operating conditions, while significant knowledge-based design conclusions have also been reported. The results show the utility of this numerical model as a rating and design tool for heat exchangers manufacturers, being a reasonable compromise between classic ε - NTU methods and CFD

  1. Frequency Upconversion and Parametric Surface Instabilities in Microwave Plasma Interactions.

    Science.gov (United States)

    Rappaport, Harold Lee

    In this thesis the interaction of radiation with plasmas whose density profiles are nearly step functions of space and/or time are studied. The wavelengths of radiation discussed are large compared with plasma density gradient scale lengths. The frequency spectra are evaluated and the energy balance investigated for the transmitted and reflected transient electromagnetic waves that are generated when a monochromatic source drives a finite width plasma in which a temporal step increase in density occurs. Transmission resonances associated with the abrupt boundaries manifest themselves as previously unreported multiple frequency peaks in the transmitted electromagnetic spectrum. A tunneling effect is described in which a burst of energy is transmitted from the plasma immediately following a temporal density transition. Stability of an abruptly bounded plasma, one for which the incident radiation wavelength is large compared with the plasma density gradient scale length, is investigated for both s and p polarized radiation types. For s-polarized radiation a new formalism is introduced in which pump induced perturbations are expressed as an explicit superposition of linear and non-linear plasma half-space modes. Results for a particular regime and a summary of relevant literature is presented. We conclude that when s-polarized radiation acts alone on an abrupt diffusely bounded underdense plasma stimulated excitation of electron surface modes is suppressed. For p-polarized radiation the recently proposed Lagrangian Frame Two-Plasmon Decay mode (LFTPD) ^dag is investigated in the regime in which the instability is not resonantly coupled to surface waves propagating along the boundary region. In this case, spatially dependent growth rate profiles and spatially dependent transit layer magnetic fields are reported. The regime is of interest because we have found that when the perturbation wavenumber parallel to the boundary is less than the pump frequency divided by twice

  2. Genomic instability induced by 60Co γ ray radiation in normal human liver cells

    International Nuclear Information System (INIS)

    Gen Xiaohua; Guo Xianhua; Zuo Yahui; Wang Xiaoli; Wang Zhongwen

    2007-01-01

    Objective: To explore the genomic instability induced by 60 Co γ rays. Methods: The cloning efficiency and micronucleus efficiency of normal human liver cell irradiated by 60 Co γ rays were detected, and the method of single cell gel electrophoresis (SCGE) was carried out to measure DNA chains damage. The fast-growing cells were divided into different dose-groups and then irradiated by 60 Co γ rays. After 40 populations doubling, the progenies were secondly irradiated with 2 Gy 60 Co γ rays. Results: The cloning efficiency decreased with the increase of doses after the initial irradiation. After the survival cells were given second irradiation, both results of SCGE and micronucleus frequency showed that the second damage was correlated with the original irradiation doses. Conclusions: 60 Co γ rays can not only induce the immediate biological effects in liver cells, but also lead to the genomic instability in the descendants that leads to an enhanced frequency of genetic changes occurring among the progeny of the original irradiated cell. The expanding effect of second event helps to study the genomic instability. (authors)

  3. Pomegranate Intake Protects Against Genomic Instability Induced by Medical X-rays In Vivo in Mice.

    Science.gov (United States)

    Nallanthighal, Sameera; Shirode, Amit B; Judd, Julius A; Reliene, Ramune

    2016-01-01

    Ionizing radiation (IR) is a well-documented human carcinogen. The increased use of IR in medical procedures has doubled the annual radiation dose and may increase cancer risk. Genomic instability is an intermediate lesion in IR-induced cancer. We examined whether pomegranate extract (PE) suppresses genomic instability induced by x-rays. Mice were treated orally with PE and exposed to an x-ray dose of 2 Gy. PE intake suppressed x-ray-induced DNA double-strand breaks (DSBs) in peripheral blood and chromosomal damage in bone marrow. We hypothesized that PE-mediated protection against x-ray-induced damage may be due to the upregulation of DSB repair and antioxidant enzymes and/or increase in glutathione (GSH) levels. We found that expression of DSB repair genes was not altered (Nbs1 and Rad50) or was reduced (Mre11, DNA-PKcs, Ku80, Rad51, Rad52 and Brca2) in the liver of PE-treated mice. Likewise, mRNA levels of antioxidant enzymes were reduced (Gpx1, Cat, and Sod2) or were not altered (HO-1 and Sod1) as a function of PE treatment. In contrast, PE-treated mice with and without IR exposure displayed higher hepatic GSH concentrations than controls. Thus, ingestion of pomegranate polyphenols is associated with inhibition of x-ray-induced genomic instability and elevated GSH, which may reduce cancer risk.

  4. Radiation induced chromosomal instability in lymphocytes of cancer patients

    International Nuclear Information System (INIS)

    Sudo, H.; Sagara, M.; Ban, S.; Noda, S.; Iwakawa, M.; Harada, Y.; Imai, T.; Cologne, J.B.

    2003-01-01

    Full text: Cytokinesis-blocked micronucleus (CBMN) assay has been extensively used to evaluate the radiation sensitivity of human individuals. Using the CBMN assay, Scott et al (1998, 1999) demonstrated that a fraction of radiosensitive individuals in breast cancer case population was larger than in normal individual population. However, Vral et al were very skeptical about the Scott et al's findings (2002). Under the approval from the ethical committee of NIRS, peripheral blood was obtained from 46 normal healthy females, 131 breast cancer patients, 32 cervical cancer patients and 7 female head and neck cancer patients. Radiosensitivity of T-lymphocytes was assessed by using a CBMN assay. The frequencies of MN per binucleated cell in healthy donors were 0.031(±0.010) and 0.151(±0.066) for cells treated before and after X-ray-irradiation (2Gy), respectively. Spontaneous MN frequencies in cancer patients were significantly higher than healthy donors (p < 0.001). Radiation sensitivities of breast- and head and neck-cancer patients were significantly higher than normal individuals (p < 0.001). Cervical cancer patients were more resistant to irradiation than healthy donors, though the number of cases for statistical analysis was small. (p < 0.001). We are considering that the HPV infection affected the radiosensitivity of cervical cancer cases. Because it is widely believed that one key mechanism which leads to spontaneous micronucleus formation involves an imbalance of chromosomal segregation and a chromosomal instability in patients' lymphocytes might be greater than that in normal individuals' lymphocytes. Recently, Kuschel et al (2002) demonstrated that ratios in two SNPs on XRCC3 were significantly different between cancer patients and healthy females. Then, we can suppose that the radiation-related genes with low penetrance may be involved in tumorigenesis of mammary- and head and neck-cells, and also, in patients' radiation susceptibility

  5. Towards Stabilizing Parametric Active Contours

    DEFF Research Database (Denmark)

    Liu, Jinchao; Fan, Zhun; Olsen, Søren Ingvor

    2014-01-01

    Numerical instability often occurs in evolving of parametric active contours. This is mainly due to the undesired change of parametrization during evolution. In this paper, we propose a new tangential diffusion term to compensate this undesired change. As a result, the parametrization will converge...

  6. Bystander-mediated genomic instability after high LET radiation in murine primary haemopoietic stem cells

    International Nuclear Information System (INIS)

    Bowler, Deborah A.; Moore, Stephen R.; Macdonald, Denise A.; Smyth, Sharon H.; Clapham, Peter; Kadhim, Munira A.

    2006-01-01

    Communication between irradiated and unirradiated (bystander) cells can result in responses in unirradiated cells that are similar to responses in their irradiated counterparts. The purpose of the current experiment was to test the hypothesis that bystander responses will be similarly induced in primary murine stem cells under different cell culture conditions. The experimental systems used here, co-culture and media transfer, are similar in that they both restrict communication between irradiated and bystander cells to media borne factors, but are distinct in that with the media transfer technique, cells can only communicate after irradiation, and with co-culture, cells can communication before, during and after irradiation. In this set of parallel experiments, cell type, biological endpoint, and radiation quality and dose, were kept constant. In both experimental systems, clonogenic survival was significantly decreased in all groups, whether irradiated or bystander, suggesting a substantial contribution of bystander effects (BE) to cell killing. Genomic instability (GI) was induced under all radiation and bystander conditions in both experiments, including a situation where unirradiated cells were incubated with media that had been conditioned for 24 h with irradiated cells. The appearance of delayed aberrations (genomic instability) 10-13 population doublings after irradiation was similar to the level of initial chromosomal damage, suggesting that the bystander factor is able to induce chromosomal alterations soon after irradiation. Whether these early alterations are related to those observed at later timepoints remains unknown. These results suggest that genomic instability may be significantly induced in a bystander cell population whether or not cells communicate during irradiation

  7. Competing Turing and Faraday Instabilities in Longitudinally Modulated Passive Resonators.

    Science.gov (United States)

    Copie, François; Conforti, Matteo; Kudlinski, Alexandre; Mussot, Arnaud; Trillo, Stefano

    2016-04-08

    We experimentally investigate the interplay of Turing (modulational) and Faraday (parametric) instabilities in a bistable passive nonlinear resonator. The Faraday branch is induced via parametric resonance owing to a periodic modulation of the resonator dispersion. We show that the bistable switching dynamics is dramatically affected by the competition between the two instability mechanisms, which dictates two completely novel scenarios. At low detunings from resonance, switching occurs between the stable stationary lower branch and the Faraday-unstable upper branch, whereas at high detunings we observe the crossover between the Turing and Faraday periodic structures. The results are well explained in terms of the universal Lugiato-Lefever model.

  8. A study of parametric instability in a harmonic gyrotron: Designs of third harmonic gyrotrons at 94 GHz and 210 GHz

    International Nuclear Information System (INIS)

    Saraph, G.P.; Antonsen, T.M. Jr.; Nusinovich, G.S.; Levush, B.

    1995-01-01

    Mode competition can present a major hurdle in achieving stable, efficient operation of a gyrotron at the cyclotron harmonics. A type of mode interaction in which three modes at different cyclotron harmonics are parametrically coupled together is analyzed here. This coupling can lead to parametric excitation or suppression of a mode; cyclic mode hopping; or the coexistence of three modes. Simulation results are presented for the parametric instability involving modes at the fundamental, second harmonic, and third harmonic of the cyclotron frequency. It is shown that the parametric excitation can lead to stable, efficient operation of a high-power gyrotron at the third harmonic. Based on this phenomenon, two practical designs are presented here for the third harmonic operation at 94 and 210 GHz. copyright 1995 American Institute of Physics

  9. Parametric variation of radiated power in Aditya Tokamak

    International Nuclear Information System (INIS)

    Tahiliani, Kumudni; Chowdhuri, M.B.; Manchanda, R.

    2017-01-01

    We report the study of parametric variation of radiated power in Aditya Tokamak for ohmic discharges. The radiated power was measured using AXUV diodes that are responsive to radiation in the range 1 eV to 4 keV and are insensitive to the neutral particles (<0.5 keV). Hence only the radiation power loss is measured and charge exchange losses are excluded. The measured radiated power was also used for the estimation of the effective ion charge, Z eff based on the scaling obtained by the regression analysis of the data from multiple Tokamaks. The estimated values were compared with the experimental Z eff values obtained from the visible continuum measurement. We also tested the scaling for modelled radiation power loss. (author)

  10. Tunable surface plasmon instability leading to emission of radiation

    Energy Technology Data Exchange (ETDEWEB)

    Gumbs, Godfrey [Department of Physics and Astronomy, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065 (United States); Donostia International Physics Center (DIPC), P de Manuel Lardizabal, 4, 20018 San Sebastian, Basque Country (Spain); Iurov, Andrii, E-mail: aiurov@chtm.unm.edu [Department of Physics and Astronomy, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065 (United States); Center for High Technology Materials, University of New Mexico, Albuquerque, New Mexico 87106 (United States); Huang, Danhong [Air Force Research Laboratory, Space Vehicles Directorate, Kirtland Air Force Base, New Mexico 87117 (United States); Pan, Wei [Sandia National Laboratory, Albuquerque, New Mexico 87185 (United States)

    2015-08-07

    We propose a new approach for energy conversion from a dc electric field to tunable terahertz emission based on hybrid semiconductors by combining two-dimensional (2D) crystalline layers and a thick conducting material with possible applications for chemical analysis, security scanning, medical (single-molecule) imaging, and telecommunications. The hybrid nano-structure may consist of a single or pair of sheets of graphene, silicene, or a 2D electron gas. When an electric current is passed through a 2D layer, we discover that two low-energy plasmon branches exhibit a characteristic loop in their dispersion before they merge into an unstable region beyond a critical wave vector q{sub c}. This finite q{sub c} gives rise to a wavenumber cutoff in the emission dispersion of the surface plasmon induced instability and emission of radiation (spiler). However, there is no instability for a single driven layer far from the conductor, and the instability of an isolated pair of 2D layers occurs without a wavenumber cutoff. The wavenumber cutoff is found to depend on the conductor electron density, layer separation, distances of layers from the conductor surface, and the driving-current strength.

  11. Bystander effects, adaptive response and genomic instability induced by prenatal irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Streffer, Christian [Institute for Science and Ethics, University Duisburg-Essen, Auf dem Sutan 12, D-45239 Essen (Germany)]. E-mail: streffer.essen@t-online.de

    2004-12-02

    The developing human embryo and fetus undergo very radiosensitive stages during the prenatal development. It is likely that the induction of low dose related effects such as bystander effects, the adaptive response, and genomic instability would have profound effects on embryonic and fetal development. In this paper, I review what has been reported on the induction of these three phenomena in exposed embryos and fetuses. All three phenomena have been shown to occur in murine embryonic or fetal cells and structures, although the induction of an adaptive response (and also likely the induction of bystander effects) are limited in terms of when during development they can be induced and the dose or dose-rate used to treat animals in utero. In contrast, genomic instability can be induced throughout development, and the effects of radiation exposure on genome instability can be observed for long times after irradiation including through pre- and postnatal development and into the next generation of mice. There are clearly strain-specific differences in the induction of these phenomena and all three can lead to long-term detrimental effects. This is true for the adaptive response as well. While induction of an adaptive response can make fetuses more resistant to some gross developmental defects induced by a subsequent high dose challenge with ionizing radiation, the long-term effects of this low dose exposure are detrimental. The negative effects of all three phenomena reflect the complexity of fetal development, a process where even small changes in the timing of gene expression or suppression can have dramatic effects on the pattern of biological events and the subsequent development of the mammalian organism.

  12. Anomalous phenomena in ECRH experiments at toroidal devices and low-threshold parametric decay instabilities

    Directory of Open Access Journals (Sweden)

    Saveliev A.N.

    2012-09-01

    Full Text Available In the paper the possibility of total 3D trapping of electron Bernstein (EB waves in the tokamak equatorial plane in the vicinity of the local density maximum produced by electron pump-out-effect is demonstrated. Thresholds and growth rates of the associated absolute (temporally growing parametric decay instability (PDI leading to anomalous absorption is predicted in the range of less than 100 kW. Its possible role in explanation of ion acceleration observed in ECRH experiments as well as in redistribution of the deposited power is discussed.

  13. Perspectives on the role of bystander effect and genomic instability on therapy-induced secondary malignancy

    International Nuclear Information System (INIS)

    Perumal, Venkatachalam; Raavi, Venkateswarlu; Kanagaraj, Karthik; Shangamithra, V.; Paul, Solomon F.D.; Chinnadurai, M.

    2017-01-01

    Deviation from the orchestra of regulated cell division into unregulated and then result into the formation of tumor, is known as carcinogenesis. While causes and hallmarks of many cancer types are well established, newer concepts on tumor cell response to treatment, challenges established therapeutic regime and drives into alternative toward the better management. The phenomena of therapeutics induced bystander response, and genomic instability on late effects of cancer therapy is emerging as a newer challenge. Bystander response is defined as the manifestation of radiation/chemotherapy drug signatures on the unexposed cells which are in the closer vicinity of the directly exposed; on the other hand, genomic instability is defined as the expression of radiation/chemotherapy drug signatures in the progeny of exposed cells. Unequivocally, existence of those phenomena has been demonstrated with many cell types (both in vitro and in vivo) followed by radiation and widely used chemotherapeutic drugs. Nevertheless, it is also revealed that the effects are variable and depend on dose, type of radiation/chemicals agents, experimental model, type of donor and recipient cells, and biomarkers adopted; moreover, to observe those effects, reactive oxygen species has been reported as leading mediators of those responses when compared to other molecules such as interleukins, cytokines, and inflammatory markers. Available data on those phenomena and our findings suggest that a role of therapeutic drugs induced bystander effects, and genomic instability on the development of secondary malignancy cannot be ruled out completely. (author)

  14. Mechanisms of cadmium induced genomic instability

    Energy Technology Data Exchange (ETDEWEB)

    Filipic, Metka, E-mail: metka.filipic@nib.si [National Institute of Biology, Department for Genetic Toxicology and Cancer Biology, Ljubljana (Slovenia)

    2012-05-01

    Cadmium is an ubiquitous environmental contaminant that represents hazard to humans and wildlife. It is found in the air, soil and water and, due to its extremely long half-life, accumulates in plants and animals. The main source of cadmium exposure for non-smoking human population is food. Cadmium is primarily toxic to the kidney, but has been also classified as carcinogenic to humans by several regulatory agencies. Current evidence suggests that exposure to cadmium induces genomic instability through complex and multifactorial mechanisms. Cadmium dose not induce direct DNA damage, however it induces increase in reactive oxygen species (ROS) formation, which in turn induce DNA damage and can also interfere with cell signalling. More important seems to be cadmium interaction with DNA repair mechanisms, cell cycle checkpoints and apoptosis as well as with epigenetic mechanisms of gene expression control. Cadmium mediated inhibition of DNA repair mechanisms and apoptosis leads to accumulation of cells with unrepaired DNA damage, which in turn increases the mutation rate and thus genomic instability. This increases the probability of developing not only cancer but also other diseases associated with genomic instability. In the in vitro experiments cadmium induced effects leading to genomic instability have been observed at low concentrations that were comparable to those observed in target organs and tissues of humans that were non-occupationally exposed to cadmium. Therefore, further studies aiming to clarify the relevance of these observations for human health risks due to cadmium exposure are needed.

  15. Mechanisms of cadmium induced genomic instability

    International Nuclear Information System (INIS)

    Filipič, Metka

    2012-01-01

    Cadmium is an ubiquitous environmental contaminant that represents hazard to humans and wildlife. It is found in the air, soil and water and, due to its extremely long half-life, accumulates in plants and animals. The main source of cadmium exposure for non-smoking human population is food. Cadmium is primarily toxic to the kidney, but has been also classified as carcinogenic to humans by several regulatory agencies. Current evidence suggests that exposure to cadmium induces genomic instability through complex and multifactorial mechanisms. Cadmium dose not induce direct DNA damage, however it induces increase in reactive oxygen species (ROS) formation, which in turn induce DNA damage and can also interfere with cell signalling. More important seems to be cadmium interaction with DNA repair mechanisms, cell cycle checkpoints and apoptosis as well as with epigenetic mechanisms of gene expression control. Cadmium mediated inhibition of DNA repair mechanisms and apoptosis leads to accumulation of cells with unrepaired DNA damage, which in turn increases the mutation rate and thus genomic instability. This increases the probability of developing not only cancer but also other diseases associated with genomic instability. In the in vitro experiments cadmium induced effects leading to genomic instability have been observed at low concentrations that were comparable to those observed in target organs and tissues of humans that were non-occupationally exposed to cadmium. Therefore, further studies aiming to clarify the relevance of these observations for human health risks due to cadmium exposure are needed.

  16. High frequency parametric wave phenomena and plasma heating: a review

    International Nuclear Information System (INIS)

    Porkolab, M.

    1975-11-01

    A survey of parametric instabilities in plasma, and associated particle heating, is presented. A brief summary of linear theory is given. The physical mechanism of decay instability, the purely growing mode (oscillating two-stream instability) and soliton and density cavity formation is presented. Effects of density gradients are discussed. Possible nonlinear saturation mechanisms are pointed out. Experimental evidence for the existence of parametric instabilities in both unmagnetized and magnetized plasmas is reviewed in some detail. Experimental observation of plasma heating associated with the presence of parametric instabilities is demonstrated by a number of examples. Possible application of these phenomena to heating of pellets by lasers and heating of magnetically confined fusion plasmas by high power microwave sources is discussed

  17. Light-induced ion-acoustic instability of rarefied plasma

    International Nuclear Information System (INIS)

    Krasnov, I.V.; Sizykh, D.V.

    1987-01-01

    A new method of ion-acoustic instability excitation under the effect of coherent light, resonance to ion quantum transitions on collisionless plasma, is suggested. The light-induced ion-acoustic instability (LIIAI) considered is based on the induced progressive nonequilibrium resonance particles in the field of travelling electromagnetic wave. Principal possibility to use LIIAI in high-resolution spectroscopy and in applied problems of plasma physics, related to its instability, is pointed out

  18. Telomeres and Telomerase in the Radiation Response: implications for instability, reprogramming, and carcinogenesis

    Directory of Open Access Journals (Sweden)

    Brock James Sishc

    2015-11-01

    Full Text Available Telomeres are nucleoprotein complexes comprised of tandem arrays of repetitive DNA sequence that serve to protect chromosomal termini from inappropriate degradation, as well as to prevent these natural DNA ends from being recognized as broken DNA (double-strand breaks; DSBs and triggering of inappropriate DNA damage responses. Preservation of telomere length requires telomerase, the specialized reverse transcriptase capable of maintaining telomere length via template-mediated addition of telomeric repeats onto the ends of newly synthesized chromosomes. Loss of either end-capping function or telomere length maintenance has been associated with genomic instability or senescence in a variety of settings; therefore telomeres and telomerase have well-established connections to cancer and aging. It has long been recognized that oxidative stress promotes shortening of telomeres, and that telomerase activity is a radiation-inducible function. However, the effects of ionizing radiation (IR exposure on telomeres per se are much less well understood and appreciated. To gain a deeper understanding of the roles telomeres and telomerase play in the response of human cells to ionizing radiations of different qualities, we tracked changes in telomeric end-capping function, telomere length, and telomerase activity in panels of mammary epithelial and hematopoietic cell lines exposed to low linear energy transfer (LET gamma(γ-rays or high LET high charge, high energy (HZE particles, delivered either acutely or at low dose rates (LDR. In addition to demonstrating that dysfunctional telomeres contribute to IR-induced mutation frequencies and genome instability, we reveal non-canonical roles for telomerase, in that telomerase activity was required for IR-induced enrichment of mammary epithelial putative stem/progenitor cell populations, a finding also suggestive of cellular reprogramming. Taken together, the results reported here establish the critical importance of

  19. Nonlinear theory for the parametric instability with comparable electron and ion temperatures

    International Nuclear Information System (INIS)

    Oberman, C.

    1972-01-01

    The basic linear theory of the parametric instability driven by a pump E 0 sin ω 0 t oscillating near the electron plasma frequency is reviewed. An expression is derived for the temporal nonlinear development of the fluctuation spectrum of the excited waves. For plasma with comparable electron and ion temperatures nonlinear Landau damping of electron plasma waves on ions provides the dominant nonlinearity. The steady state solutions are examined both analytically and numerically in the limit when the spontaneous emission term is small. The characteristics of the plasma wave spectrum agrees well with the general features of ionospheric observations. The enhanced dissipation rate of the pump due to the presence of the fluctuations agrees with laboratory observations. (U.S.)

  20. Causation of cancer by ionizing radiation and genomic instability

    International Nuclear Information System (INIS)

    Streffer, Christian

    2013-01-01

    The causation of cancer by ionizing radiation has been shown in many epidemiological (with exposed humans) as well as experimental studies with mammals especially mice but also rats, dogs and monkeys. Risk values have been determined in medium radiation dose ranges (∼100 to 2,000 mSv). However, in the low dose range (<100 mSv) the situation is unclear and unsolved up to now. A better knowledge of the mechanisms for the development of cancer in humans over decades after low to medium radiation exposures is necessary for the understanding of the open questions. An increase of chromosomal aberrations and other genetic changes have been frequently observed directly after radiation exposures in many cell systems including human cells. However, in 1989 it was found that an increase of genomic instability occurred after irradiation of mouse zygotes in the fibroblasts of the neonates developing from the irradiated zygotes. That means genomic instability developed many cell generations later in cells which never had been exposed to various qualities of ionizing radiations in vivo and any treatment and secondary cancers developed in photon irradiated M.Hodgkin patients preferentially in those patients who showed a comparatively high genomic instability in their lymphocytes. Since several decades it has been experienced that certain cancer patients show an extremely high radio-sensitivity. This clinical observation has been confirmed by experimental investigations with cells of such patients. It has been proven that this increased radio-sensitivity is due to genetic mutations. A number of syndromes could be defined on such a genetic basis like ataxia telangiectasia, bloom's syndrome, fanconi anemia, retinoblasoma and others. In all these syndromes mutations occur in genes which are to regulation of the cell cycle or DNA repair (preferentially repair of DSBs). These patients with an increased radio-sensitivity frequently develop cancer - very often lymphoma - and they also

  1. Radiation-induced instability of MnS precipitates and its possible consequences on irradiation-induced stress corrosion cracking of austenitic stainless steels

    International Nuclear Information System (INIS)

    Chung, H.M.; Sanecki, J.E.; Garner, F.A.

    1996-12-01

    Irradiation-assisted stress corrosion cracking (IASCC) is a significant materials issue for the light water reactor (LWR) industry and may also pose a problem for fusion power reactors that will use water as coolant. A new metallurgical process is proposed that involves the radiation-induced release into solution of minor impurity elements not usually thought to participate in IASCC. MnS-type precipitates, which contain most of the sulfur in stainless steels, are thought to be unstable under irradiation. First, Mn transmutes strongly to Fe in thermalized neutron spectra. Second, cascade-induced disordering and the inverse Kirkendall effect operating at the incoherent interfaces of MnS precipitates are thought to act as a pump to export Mn from the precipitate into the alloy matrix. Both of these processes will most likely allow sulfur, which is known to exert a deleterious influence on intergranular cracking, to re-enter the matrix. To test this hypothesis, compositions of MnS-type precipitates contained in several unirradiated and irradiated heats of Type 304, 316, and 348 stainless steels (SSs) were analyzed by Auger electron spectroscopy. Evidence is presented that shows a progressive compositional modification of MnS precipitates as exposure to neutrons increases in boiling water reactors. As the fluence increases, the Mn level in MnS decreases, whereas the Fe level increases. The S level also decreases relative to the combined level of Mn and Fe. MnS precipitates were also found to be a reservoir of other deleterious impurities such as F and O which could be also released due to radiation-induced instability of the precipitates

  2. Absolute differential yield of parametric x-ray radiation

    International Nuclear Information System (INIS)

    Shchagin, A.V.; Pristupa, V.I.; Khizhnyak, N.A.

    1993-01-01

    The results of measurements of absolute differential yield of parametric X-ray radiation (PXR) in thin single crystal are presented for the first time. It has been established that the experimental results are in good agreement with theoretical calculations according with kinematical theory. The influence of density effect on PXR properties is discussed. (author). 19 refs., 7 figs

  3. Influence of Physical and Geometrical Uncertainties in the Parametric Instability Load of an Axially Excited Cylindrical Shell

    Directory of Open Access Journals (Sweden)

    Frederico Martins Alves da Silva

    2015-01-01

    Full Text Available This work investigates the influence of Young’s modulus, shells thickness, and geometrical imperfection uncertainties on the parametric instability loads of simply supported axially excited cylindrical shells. The Donnell nonlinear shallow shell theory is used for the displacement field of the cylindrical shell and the parameters under investigation are considered as uncertain parameters with a known probability density function in the equilibrium equation. The uncertainties are discretized as Hermite-Chaos polynomials together with the Galerkin stochastic procedure that discretizes the stochastic equation in a set of deterministic equations of motion. Then, a general expression for the transversal displacement is obtained by a perturbation procedure which identifies all nonlinear modes that couple with the linear modes. So, a particular solution is selected which ensures the convergence of the response up to very large deflections. Applying the standard Galerkin method, a discrete system in time domain that considers the uncertainties is obtained and solved by fourth-order Runge-Kutta method. Several numerical strategies are used to study the nonlinear behavior of the shell considering the uncertainties in the parameters. Special attention is given to the influence of the uncertainties on the parametric instability and time response, showing that the Hermite-Chaos polynomial is a good numerical tool.

  4. Radiation-induced cancer

    International Nuclear Information System (INIS)

    Dutrillaux, B.; CEA Fontenay-aux-Roses, 92

    1998-01-01

    The induction of malignant diseases is one of the most concerning late effects of ionising radiation. A large amount of information has been collected form atomic bomb survivors, patients after therapeutic irradiation, occupational follow-up and accidentally exposed populations. Major uncertainties persist in the (very) low range i.e, population and workers radioprotection. A review of the biological mechanisms leading to cancer strongly suggests that the vast majority of radiation-induced malignancies arise as a consequence of recessive mutations can be unveiled by ageing, this process being possibly furthered by constitutional or acquired genomic instability. The individual risk is likely to be very low, probably because of the usual dose level. However, the magnitude of medical exposure and the reliance of our societies on nuclear industry are so high that irreproachable decision-making processes and standards for practice are inescapable. (author)

  5. Delayed chromosomal instability caused by large deletion

    International Nuclear Information System (INIS)

    Ojima, M.; Suzuki, K.; Kodama, S.; Watanabe, M.

    2003-01-01

    Full text: There is accumulating evidence that genomic instability, manifested by the expression of delayed phenotypes, is induced by X-irradiation but not by ultraviolet (UV) light. It is well known that ionizing radiation, such as X-rays, induces DNA double strand breaks, but UV-light mainly causes base damage like pyrimidine dimers and (6-4) photoproducts. Although the mechanism of radiation-induced genomic instability has not been thoroughly explained, it is suggested that DNA double strand breaks contribute the induction of genomic instability. We examined here whether X-ray induced gene deletion at the hprt locus induces delayed instability in chromosome X. SV40-immortalized normal human fibroblasts, GM638, were irradiated with X-rays (3, 6 Gy), and the hprt mutants were isolated in the presence of 6-thioguanine (6-TG). A 2-fold and a 60-fold increase in mutation frequency were found by 3 Gy and 6 Gy irradiation, respectively. The molecular structure of the hprt mutations was determined by multiplex polymerase chain reaction of nine exons. Approximately 60% of 3 Gy mutants lost a part or the entire hprt gene, and the other mutants showed point mutations like spontaneous mutants. All 6 Gy mutants show total gene deletion. The chromosomes of the hprt mutants were analyzed by Whole Human Chromosome X Paint FISH or Xq telomere FISH. None of the point or partial gene deletion mutants showed aberrations of X-chromosome, however total gene deletion mutants induced translocations and dicentrics involving chromosome X. These results suggest that large deletion caused by DNA double strand breaks destabilizes chromosome structure, which may be involved in an induction of radiation-induced genomic instability

  6. Dioxin induces genomic instability in mouse embryonic fibroblasts.

    Directory of Open Access Journals (Sweden)

    Merja Korkalainen

    Full Text Available Ionizing radiation and certain other exposures have been shown to induce genomic instability (GI, i.e., delayed genetic damage observed many cell generations later in the progeny of the exposed cells. The aim of this study was to investigate induction of GI by a nongenotoxic carcinogen, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD. Mouse embryonic fibroblasts (C3H10T1/2 were exposed to 1, 10 or 100 nM TCDD for 2 days. Micronuclei (MN and expression of selected cancer-related genes were assayed both immediately and at a delayed point in time (8 days. For comparison, similar experiments were done with cadmium, a known genotoxic agent. TCDD treatment induced an elevated frequency of MN at 8 days, but not directly after the exposure. TCDD-induced alterations in gene expression were also mostly delayed, with more changes observed at 8 days than at 2 days. Exposure to cadmium produced an opposite pattern of responses, with pronounced effects immediately after exposure but no increase in MN and few gene expression changes at 8 days. Although all responses to TCDD alone were delayed, menadione-induced DNA damage (measured by the Comet assay, was found to be increased directly after a 2-day TCDD exposure, indicating that the stability of the genome was compromised already at this time point. The results suggested a flat dose-response relationship consistent with dose-response data reported for radiation-induced GI. These findings indicate that TCDD, although not directly genotoxic, induces GI, which is associated with impaired DNA damage response.

  7. Radiation-induced instability of MnS precipitates and its possible consequences on IASCC of austenitic stainless steels

    International Nuclear Information System (INIS)

    Chung, H.M.; Garner, F.A.

    1996-01-01

    Irradiation assisted stress corrosion cracking (IASCC) continues to be a significant materials issue for the light water reactor industry and may also pose a problem for fusion power devices that employ water cooling. Although a number of potential mechanisms have been proposed to participate in this phenomenon, at this time it is not clear that any of these candidate mechanisms are sufficient to rationalize the observed failures. A new mechanism is proposed in this paper that involves the radiation-induced release into solution of elements not usually thought to participate in IASCC. It is shown in this paper that MnS precipitates, which contain most of the sulphur in stainless steels, are probably unstable under irradiation. First, the Mn transmutes very strongly to Fe in highly thermalized neutron spectra. Second, the combination of cascade-induced disordering and the inverse-Kirkendall effect operating at the incoherent interfaces of MnS precipitates will probably act as a pump to export Mn from the precipitate surface into the alloy matrix. Both of these processes will most likely allow some of the sulphur to re-enter the alloy matrix. Sulphur is known to exert a deleterious influence on grain boundary cracking. MnS precipitates are also thought to be a reservoir of other deleterious impurities such as fluorine which could be also released due to radiation-induced instability of the precipitates. This possibility has been confirmed by Auger electron spectroscopy of Types 304, 316, and 348 stainless steel specimens sectioned from several BWR components irradiated up to 3.5x10 21 n/cm 2 (E > 1 MeV)

  8. Radiation-induced instability of MnS precipitates and its possible consequences on IASCC of austenitic stainless steels

    Energy Technology Data Exchange (ETDEWEB)

    Chung, H.M. [Argonne National Lab., IL (United States); Garner, F.A. [Pacific Northwest National Lab., Richland, WA (United States)

    1996-10-01

    Irradiation assisted stress corrosion cracking (IASCC) continues to be a significant materials issue for the light water reactor industry and may also pose a problem for fusion power devices that employ water cooling. Although a number of potential mechanisms have been proposed to participate in this phenomenon, at this time it is not clear that any of these candidate mechanisms are sufficient to rationalize the observed failures. A new mechanism is proposed in this paper that involves the radiation-induced release into solution of elements not usually thought to participate in IASCC. It is shown in this paper that MnS precipitates, which contain most of the sulphur in stainless steels, are probably unstable under irradiation. First, the Mn transmutes very strongly to Fe in highly thermalized neutron spectra. Second, the combination of cascade-induced disordering and the inverse-Kirkendall effect operating at the incoherent interfaces of MnS precipitates will probably act as a pump to export Mn from the precipitate surface into the alloy matrix. Both of these processes will most likely allow some of the sulphur to re-enter the alloy matrix. Sulphur is known to exert a deleterious influence on grain boundary cracking. MnS precipitates are also thought to be a reservoir of other deleterious impurities such as fluorine which could be also released due to radiation-induced instability of the precipitates. This possibility has been confirmed by Auger electron spectroscopy of Types 304, 316, and 348 stainless steel specimens sectioned from several BWR components irradiated up to 3.5x10{sup 21} n/cm{sup 2} (E > 1 MeV).

  9. Physical mechanism of parametric instabilities near the lower-hybrid frequency in inhomogeneous plasma

    International Nuclear Information System (INIS)

    Porkolab, M.

    1974-10-01

    The dispersion relation for parametric instabilities near the lower-hybrid frequency is obtained from model fluid equations. The following instabilities are discussed: for rf pump frequencies ω 0 greater than or equal to 3ω/sub LH/, ω/sub pe/ approximately equal to Ω/sub e/, resonant decay into ion sound (ion cyclotron) modes (previously predicted) is found. In the regime of 1 less than or equal to ω 0 /ω/sub LH/ less than or equal to 3, ω/sub pe/ approximately equal to Ω/sub e/, decay into ion quasi-modes is found. In strong magnetic fields decay into quasi-modes is also found for 3 less than or equal to ω 0 /ω/sub LH/. This mechanism is similar to nonlinear Landau damping in weak turbulence theory. In addition, decay into the purely growing mode and fluid-quasi modes may also occur. The results are compared with recent calculations from the Vlasov equation. The effects of plasma-inhomogeneities are considered, including effective thresholds due to density gradients and finite pump extent. The implications of these results to rf heating of tokamaks near the lower-hybrid frequency are discussed. (auth)

  10. Observation of parametric X-ray radiation in an anomalous diffraction region

    Energy Technology Data Exchange (ETDEWEB)

    Alexeyev, V.I., E-mail: vial@x4u.lebedev.ru [P.N. Lebedev Physical Institute RAS, 53 Leninskiy prospect, Moscow (Russian Federation); Belgorod National Research University, 85 Pobedy st., Belgorod (Russian Federation); Eliseyev, A.N., E-mail: elisseev@pluton.lpi.troitsk.ru [P.N. Lebedev Physical Institute RAS, 53 Leninskiy prospect, Moscow (Russian Federation); Belgorod National Research University, 85 Pobedy st., Belgorod (Russian Federation); Irribarra, E., E-mail: esteban.irribarra@epn.edu.ec [Escuela Politécnica Nacional, Ladrón de Guevara E11-253, Quito (Ecuador); Kishin, I.A., E-mail: ivan.kishin@mail.ru [P.N. Lebedev Physical Institute RAS, 53 Leninskiy prospect, Moscow (Russian Federation); Belgorod National Research University, 85 Pobedy st., Belgorod (Russian Federation); Kubankin, A.S., E-mail: kubankin@bsu.edu.ru [P.N. Lebedev Physical Institute RAS, 53 Leninskiy prospect, Moscow (Russian Federation); Belgorod National Research University, 85 Pobedy st., Belgorod (Russian Federation); Nazhmudinov, R.M., E-mail: fizeg@bk.ru [P.N. Lebedev Physical Institute RAS, 53 Leninskiy prospect, Moscow (Russian Federation); Belgorod National Research University, 85 Pobedy st., Belgorod (Russian Federation)

    2016-08-19

    A new possibility to expand the energy region of diffraction processes based on the interaction of relativistic charged particles with crystalline structures is presented. Diffracted photons related to parametric X-ray radiation produced by relativistic electrons are detected below the low energy threshold for the X-ray diffraction mechanism in crystalline structures for the first time. The measurements were performed during the interaction of 7 MeV electrons with a textured polycrystalline tungsten foil and a highly oriented pyrolytic graphite crystal. The experiment results are in good agreement with a developed model based on the PXR kinematical theory. The developed experimental approach can be applied to separate the contributions of real and virtual photons to the total diffracted radiation generated during the interaction of relativistic charged particles with crystalline targets. - Highlights: • Parametric X-ray radiation below the low energy threshold for diffraction of free X-rays. • Experimental separation of the contributions from different radiation mechanisms. • PXR from relativistic electrons in mosaic crystals and textured polycrystlas.

  11. A review of investigations on flow instabilities in natural circulation boiling loops

    International Nuclear Information System (INIS)

    Gonella V Durga Prasad; Manmohan Pandey; Manjeet S Kalra

    2005-01-01

    Full text of publication follows: Steam generation systems are subjected to flow instabilities due to parametric fluctuations, inlet conditions etc., which may result in mechanical vibrations of components (called flow induced vibrations) and system control problems. Analysis of these instabilities in natural circulation boiling loops is very important for the safety of nuclear reactors and other boiling systems. This paper presents the state of the art in this area by reviewing over 100 contributions made in the past 30 years. A large number of experimental and numerical investigations have been conducted to study and understand the conditions for inception of flow instabilities, parametric effects of instabilities, and the system behavior under such conditions. Work done on instabilities due to channel thermal-hydraulics as well as neutronics-thermohydraulics coupling has been reviewed. Different methods of analysis used by researchers and results obtained by them have been discussed. Various numerical techniques adopted and computer codes developed have also been discussed. The knowledge obtained from the investigations made in the past three decades has been summarized to present the state of the art of the understanding of flow instabilities. (authors)

  12. Jeans instability of rotating magnetized quantum plasma: Influence of radiation

    Energy Technology Data Exchange (ETDEWEB)

    Joshi, H., E-mail: hjoshi8525@yahoo.com [Department of Physics, Mewar University, Chittorgarh (Raj.) India (India); Pensia, R. K. [Department of Physics, Govt. Girls College, Neemuch (M.P.) India (India)

    2015-07-31

    The effect of radiative heat-loss function and rotation on the Jeans instability of quantum plasma is investigated. The basic set of equations for this problem is constructed by considering quantum magnetohydrodynamic (QMHD) model. Using normal mode analysis, the general dispersion relation is obtained. This dispersion relation is studied in both, longitudinal and transverse direction of propagations. In both case of longitudinal and transverse direction of propagation, the Jeans instability criterion is modified due to presence of radiative heat-loss function and quantum correction.

  13. Nonlinear-optical generation of short-wavelength radiation controlled by laser-induced interference structures

    International Nuclear Information System (INIS)

    Popov, A K; Kimberg, V V

    1998-01-01

    A study is reported of the combined influence of laser-induced resonances in the energy continuum, of splitting of discrete resonances in the field of several strong radiations, and of absorption of the initial and generated radiations on totally resonant parametric conversion to the short-wavelength range. It is shown that the radiation power can be increased considerably by interference processes involving quantum transitions. (nonlinear optical phenomena and devices)

  14. Temperature dependence of parametric instabilities in the context of the shock-ignition approach to inertial confinement fusion

    Czech Academy of Sciences Publication Activity Database

    Weber, Stefan A.; Riconda, C.

    2015-01-01

    Roč. 3, Feb (2015), e6 ISSN 2095-4719 R&D Projects: GA MŠk ED1.1.00/02.0061; GA MŠk EE2.3.20.0279 Grant - others:ELI Beamlines(XE) CZ.1.05/1.1.00/02.0061; LaserZdroj (OP VK 3)(XE) CZ.1.07/2.3.00/20.0279 Institutional support: RVO:68378271 Keywords : inertial confinement fusion * shock ignition * laser- plasma interaction * parametric instabilities Subject RIV: BL - Plasma and Gas Discharge Physics

  15. Molecular Mechanisms of Radiation-Induced Genomic Instability in Human Cells

    Energy Technology Data Exchange (ETDEWEB)

    Howard L. Liber; Jeffrey L. Schwartz

    2005-10-31

    There are many different model systems that have been used to study chromosome instability. What is clear from all these studies is that conclusions concerning chromosome instability depend greatly on the model system and instability endpoint that is studied. The model system for our studies was the human B-lymphoblastoid cell line TK6. TK6 was isolated from a spontaneously immortalized lymphoblast culture. Thus there was no outside genetic manipulation used to immortalize them. TK6 is a relatively stable p53-normal immortal cell line (37). It shows low gene and chromosome mutation frequencies (19;28;31). Our general approach to studying instability in TK6 cells has been to isolate individual clones and analyze gene and chromosome mutation frequencies in each. This approach maximizes the possibility of detecting low frequency events that might be selected against in mass cultures.

  16. Formal Solutions for Polarized Radiative Transfer. III. Stiffness and Instability

    Science.gov (United States)

    Janett, Gioele; Paganini, Alberto

    2018-04-01

    Efficient numerical approximation of the polarized radiative transfer equation is challenging because this system of ordinary differential equations exhibits stiff behavior, which potentially results in numerical instability. This negatively impacts the accuracy of formal solvers, and small step-sizes are often necessary to retrieve physical solutions. This work presents stability analyses of formal solvers for the radiative transfer equation of polarized light, identifies instability issues, and suggests practical remedies. In particular, the assumptions and the limitations of the stability analysis of Runge–Kutta methods play a crucial role. On this basis, a suitable and pragmatic formal solver is outlined and tested. An insightful comparison to the scalar radiative transfer equation is also presented.

  17. Anticipating Terrorist Safe Havens from Instability Induced Conflict

    Science.gov (United States)

    Shearer, Robert; Marvin, Brett

    This chapter presents recent methods developed at the Center for Army Analysis to classify patterns of nation-state instability that lead to conflict. The ungoverned areas endemic to failed nation-states provide terrorist organizations with safe havens from which to plan and execute terrorist attacks. Identification of those states at risk for instability induced conflict should help to facilitate effective counter terrorism policy planning efforts. Nation-states that experience instability induced conflict are similar in that they share common instability factors that make them susceptible to experiencing conflict. We utilize standard pattern classification algorithms to identify these patterns. First, we identify features (political, military, economic and social) that capture the instability of a nation-state. Second, we forecast the future levels of these features for each nation-state. Third, we classify each future state’s conflict potential based upon the conflict level of those states in the past most similar to the future state.

  18. Enhancement and suppression of opto-acoustic parametric interactions using optical feedback

    International Nuclear Information System (INIS)

    Zhang Zhongyang; Zhao Chunnong; Ju, L.; Blair, D. G.

    2010-01-01

    A three mode opto-acoustic parametric amplifier (OAPA) is created when two orthogonal optical modes in a high finesse optical cavity are coupled via an acoustic mode of the cavity mirror. Such interactions are predicted to occur in advanced long baseline gravitational wave detectors. They can have high positive gain, which leads to strong parametric instability. Here we show that an optical feedback scheme can enhance or suppress the parametric gain of an OAPA, allowing exploration of three-mode parametric interactions, especially in cavity systems that have insufficient optical power to achieve spontaneous instability. We derive analytical equations and show that optical feedback is capable of controlling predicted instabilities in advanced gravitational wave detectors within a time scale of 13∼10 s.

  19. Radiation-induced hyperproliferation of intestinal crypts results in elevated genome instability with inactive p53-related genomic surveillance.

    Science.gov (United States)

    Zhou, Xin; Ma, Xiaofei; Wang, Zhenhua; Sun, Chao; Wang, Yupei; He, Yang; Zhang, Hong

    2015-12-15

    Radiation-induced hyperproliferation of intestinal crypts is well documented, but its potential tumorigenic effects remain elusive. Here we aim to determine the genomic surveillance process during crypt hyperproliferation, and its consequential outcome after ionizing radiation. Crypt regeneration in the intestine was induced by a single dose of 12Gy abdominal irradiation. γ-H2AX, 53BP1 and DNA-PKcs were used as DNA repair surrogates to investigate the inherent ability of intestinal crypt cells to recognize and repair double-strand breaks. Ki67 staining and the 5-bromo-2'-deoxyuridine incorporation assay were used to study patterns of cell proliferation in regenerating crypts. Staining for ATM, p53, Chk1 and Chk2 was performed to study checkpoint activation and release. Apoptosis was evaluated through H&E staining and terminal deoxynucleotidyl transferase (dUTP) nick-end labeling. The ATM-p53 pathway was immediately activated after irradiation. A second wave of DSBs in crypt cells was observed in regenerating crypts, accompanied with significantly increased chromosomal bridges. The p53-related genomic surveillance pathway was not active during the regeneration phase despite DSBs and chromosomal bridges in the cells of regenerating crypts. Non-homologous end joining (NHEJ) DSBs repair was involved in the DSBs repair process, as indicated by p-DNA-PKcs staining. Intestinal crypt cells retained hyperproliferation with inactive p53-related genomic surveillance system. NHEJ was involved in the resultant genomic instability during hyperproliferation. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. The role of free radicals and stress signalling in persistent genomic instability induced by long wavelength UV light

    International Nuclear Information System (INIS)

    Phillipson, R.; McMillan, T.J.

    2003-01-01

    Induction of persistent genomic instability has commonly been investigated with ionising radiation. It has been characterised as a decrease in plating efficiency, and an increase in chromosomal aberrations and mutation frequency in the progeny of cells that survive the initial irradiation. We now present data demonstrating the phenomenon following exposure to long-wavelength solar UV-A (320-400nm) radiation at environmentally relevant doses. Using the spontaneously immortalised human skin keratinocyte line, HaCaT, we observed a significant decrease in plating efficiency (77 +/- 2% of control), and increase in micronuclei (2.5 fold) and mutation frequency (2 fold), 7 days after the initial radiation insult. Modification of UV-A-induced instability by incubation with exogenous catalase implicated reactive oxygen species (ROS), in-particular hydrogen peroxide, in the production and/or maintenance of the phenomenon. Assessment of anti-oxidant enzymes revealed a significant increase in glutathione-s-transferase activity (158 +/- 4% of control) at day 7 in the irradiated cell population, which was inhibited by incubation with exogenous catalase (97 +/- 3%), providing further evidence for an ROS-mediated pathway. Furthermore, inhibition of UV-A-induced micronuclei at day 7 by the flavonoid-containing-protein inhibitor diphenyleneiodonium (DPI) indicates that the NADPH oxidase family of enzymes may be involved in this phenomenon. Measurement of superoxide production by the cytochrome c reduction assay revealed that the irradiated cell population produce 50% more superoxide than the unirradiated controls, and that incubation with DPI led to a preferential reduction in superoxide production in the UV-A treated population at day 7. Finally, NADPH oxidase activity is increased significantly over controls in UV-A-treated cells. These data demonstrate that oxidative stress, analogous to that produced by ionising radiation, induces persistent genomic instability through a

  1. Is there a genetic instability in A-bomb survivors' lymphocytes?

    International Nuclear Information System (INIS)

    Nakamura, Nori; Kodama, Yoshiaki; Awa, Akio

    1997-01-01

    Based on the reports that the genetic instability can be induced even by low LET radiation and that the instability can be essentially the cause of radiation carcinogenicity, data accumulated hitherto on the chromosome aberrations in A-bomb survivors were re-evaluated since it can be conceivable that there is still remaining a genetic instability in them. For a measure of biological radiation dose, translocation frequency was used and for genetic instability, dicentrics frequency. The relationship between those frequencies was analyzed in about 2500 survivors and showed either a saturable or linear one. For clear conclusion, additional studies on dicentrics frequency occurring in cultured lymphocytes from subjects who received various radiation doses would be necessary. (K.H.)

  2. Parametric study on kink instabilities of twisted magnetic flux ropes in the solar atmosphere

    Science.gov (United States)

    Mei, Z. X.; Keppens, R.; Roussev, I. I.; Lin, J.

    2018-01-01

    Aims: Twisted magnetic flux ropes (MFRs) in the solar atmosphere have been researched extensively because of their close connection to many solar eruptive phenomena, such as flares, filaments, and coronal mass ejections (CMEs). In this work, we performed a set of 3D isothermal magnetohydrodynamic (MHD) numerical simulations, which use analytical twisted MFR models and study dynamical processes parametrically inside and around current-carrying twisted loops. We aim to generalize earlier findings by applying finite plasma β conditions. Methods: Inside the MFR, approximate internal equilibrium is obtained by pressure from gas and toroidal magnetic fields to maintain balance with the poloidal magnetic field. We selected parameter values to isolate best either internal or external kink instability before studying complex evolutions with mixed characteristics. We studied kink instabilities and magnetic reconnection in MFRs with low and high twists. Results: The curvature of MFRs is responsible for a tire tube force due to its internal plasma pressure, which tends to expand the MFR. The curvature effect of toroidal field inside the MFR leads to a downward movement toward the photosphere. We obtain an approximate internal equilibrium using the opposing characteristics of these two forces. A typical external kink instability totally dominates the evolution of MFR with infinite twist turns. Because of line-tied conditions and the curvature, the central MFR region loses its external equilibrium and erupts outward. We emphasize the possible role of two different kink instabilities during the MFR evolution: internal and external kink. The external kink is due to the violation of the Kruskal-Shafranov condition, while the internal kink requires a safety factor q = 1 surface inside the MFR. We show that in mixed scenarios, where both instabilities compete, complex evolutions occur owing to reconnections around and within the MFR. The S-shaped structures in current distributions

  3. He{sup 2+} HEATING VIA PARAMETRIC INSTABILITIES OF PARALLEL PROPAGATING ALFVÉN WAVES WITH AN INCOHERENT SPECTRUM

    Energy Technology Data Exchange (ETDEWEB)

    He, Peng; Gao, Xinliang; Lu, Quanming; Wang, Shui, E-mail: gaoxl@mail.ustc.edu.cn [CAS Key Laboratory of Geospace Environment, Department of Geophysics and Planetary Science, University of Science and Technology of China, Hefei 230026 (China)

    2016-08-10

    The preferential heating of heavy ions in the solar corona and solar wind has been a long-standing hot topic. In this paper we use a one-dimensional hybrid simulation model to investigate the heating of He{sup 2+} particles during the parametric instabilities of parallel propagating Alfvén waves with an incoherent spectrum. The evolution of the parametric instabilities has two stages and involves the heavy ion heating during the entire evolution. In the first stage, the density fluctuations are generated by the modulation of the pump Alfvén waves with a spectrum, which then results in rapid coupling with the pump Alfvén waves and the cascade of the magnetic fluctuations. In the second stage, each pump Alfvén wave decays into a forward density mode and a backward daughter Alfvén mode, which is similar to that of a monochromatic pump Alfvén wave. In both stages the perpendicular heating of He{sup 2+} particles occurs. This is caused by the cyclotron resonance between He{sup 2+} particles and the high-frequency magnetic fluctuations, whereas the Landau resonance between He{sup 2+} particles and the density fluctuations leads to the parallel heating of He{sup 2+} particles. The influence of the drift velocity between the protons and the He{sup 2+} particles on the heating of He{sup 2+} particles is also discussed in this paper.

  4. Two-phase flow induced parametric vibrations in structural systems

    International Nuclear Information System (INIS)

    Hara, Fumio

    1980-01-01

    This paper is divided into two parts concerning piping systems and a nuclear fuel pin system. The significant experimental results concerning the random vibration induced in an L-shaped pipe by air-water two-phase flow and the theoretical analysis of the vibration are described in the first part. It was clarified for the first time that the parametric excitation due to the periodic changes of system mass, centrifugal force and Coriolis force was the mechanism of exciting the vibration. Moreover, the experimental and theoretical analyses of the mechanism of exciting vibration by air-water two-phase flow in a straight, horizontal pipe were carried out, and the first natural frequency of the piping system was strongly related to the dominant frequency of void signals. The experimental results on the vibration of a nuclear fuel pin model in parallel air-water two-phase flow are reported in the latter part. The relations between vibrational strain variance and two-phase flow velocity or pressure fluctuation, and the frequency characteristics of vibrational strain variance were obtained. The theoretical analysis of the dynamic interaction between air-water two-phase flow and a fuel pin structure, and the vibrational instability of fuel pins in alternate air and water slugs or in large bubble flow are also reported. (Kako, I.)

  5. On the instability effects in radiation-sensitive chalcogenide glasses

    International Nuclear Information System (INIS)

    Balitska, V.; Kovalskiy, A.; Shpotyuk, O.; Vakiv, M.

    2007-01-01

    The features of application of radiation-sensitive media based on chalcogenide glasses of As-Ge-S system for registration of high-energy γ-radiation are analysed. It is shown that compositional features of the observed time-instability effect should be taken into account in order to ensure a higher accuracy of the developed dosimeters

  6. On the instability effects in radiation-sensitive chalcogenide glasses

    Energy Technology Data Exchange (ETDEWEB)

    Balitska, V. [Lviv State University for Vital Activity Safety, 35 Kleparivska str., Lviv, UA-79007 (Ukraine); Lviv Institute of Materials of SRC ' Carat' , 202 Stryjska str., Lviv, UA-79031 (Ukraine); Kovalskiy, A. [Lviv Institute of Materials of SRC ' Carat' , 202 Stryjska str., Lviv, UA-79031 (Ukraine); International Materials Institute for New Functionality in Glass, Lehigh University, 5 East Packer Avenue, Bethlehem, PA 18015-3195 (United States); Shpotyuk, O. [Lviv Institute of Materials of SRC ' Carat' , 202 Stryjska str., Lviv, UA-79031 (Ukraine); International Materials Institute for New Functionality in Glass, Lehigh University, 5 East Packer Avenue, Bethlehem, PA 18015-3195 (United States)], E-mail: shpotyuk@novas.lviv.ua; Vakiv, M. [Lviv Institute of Materials of SRC ' Carat' , 202 Stryjska str., Lviv, UA-79031 (Ukraine)

    2007-04-15

    The features of application of radiation-sensitive media based on chalcogenide glasses of As-Ge-S system for registration of high-energy {gamma}-radiation are analysed. It is shown that compositional features of the observed time-instability effect should be taken into account in order to ensure a higher accuracy of the developed dosimeters.

  7. Genomic instability in mutation induction on normal human fibroblasts irradiated with chronic low-dose radiations in heavy-ion radiation field

    International Nuclear Information System (INIS)

    Suzuki, M.; Tsuruoka, C.; Uchihori, Y.; Yasuda, H.; Fujitaka, K.

    2003-01-01

    Full text: At a time when manned space exploration is more a reality with the planned the International Space Station (ISS) underway, the potential exposure of crews in a spacecraft to chronic low-dose radiations in the field of low-flux galactic cosmic rays (GCR) and the subsequent biological effects have become one of the major concerns of space science. We have studied both in vitro life span and genomic instability in cellular effects in normal human skin fibroblasts irradiated with chronic low-dose radiations in heavy-ion radiation field. Cells were cultured in a CO2 incubator, which was set in the irradiation room for the biological study of heavy ions in the Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences (NIRS), and irradiated with scattered radiations produced from heavy ions. Absorbed dose measured using a thermoluminescence dosimeter (TLD) and a Si-semiconductor detector was to be around 1.4 mGy per day when operating the HIMAC machine for biological experiments. The total population doubling number (tPDN) of low-dose irradiated cells was significantly smaller (79-93%) than that of unirradiated cells. The results indicate that the life span of the cell population shortens by irradiating with low-dose scattered radiations in the heavy-ion irradiation field. Genomic instability in cellular responses was examined to measure either cell killing or mutation induction in low-dose accumulated cells after exposing to X-ray challenging doses. The results showed that there was no enhanced effect on cell killing between low-dose accumulated and unirradiated cells after exposing to defined challenging doses of 200kV X rays. On the contrary, the mutation frequency on hprt locus of low-dose accumulated cells was much higher than that of unirradiated cells. The results suggested that genomic instability was induced in mutagenesis by the chronic low-dose irradiations in heavy-ion radiation field

  8. Temporal instability of viscous liquid microjets with spatially varying surface tension

    Energy Technology Data Exchange (ETDEWEB)

    Furlani, E P [Integrated Materials and Microstructures Laboratory, Electronic Imaging Products, Eastman Kodak Company, Rochester, NY 14650-2121 (United States)

    2005-01-07

    A linear theory is developed for the temporal instability of a viscous liquid microjet of Newtonian fluid with a spatially periodic variation of surface tension imposed along its length. The variation of surface tension induces Marangoni flow within the jet that leads to breakup and drop formation. An analytical expression is derived for the behaviour of the free surface of the microjet. This expression is useful for parametric analysis of jet instability and breakup as a function of jet radius, wavelength and fluid properties.

  9. Temporal instability of viscous liquid microjets with spatially varying surface tension

    International Nuclear Information System (INIS)

    Furlani, E P

    2005-01-01

    A linear theory is developed for the temporal instability of a viscous liquid microjet of Newtonian fluid with a spatially periodic variation of surface tension imposed along its length. The variation of surface tension induces Marangoni flow within the jet that leads to breakup and drop formation. An analytical expression is derived for the behaviour of the free surface of the microjet. This expression is useful for parametric analysis of jet instability and breakup as a function of jet radius, wavelength and fluid properties

  10. Parametric instability and wave turbulence driven by tidal excitation of internal waves

    Science.gov (United States)

    Le Reun, Thomas; Favier, Benjamin; Le Bars, Michael

    2018-04-01

    We investigate the stability of stratified fluid layers undergoing homogeneous and periodic tidal deformation. We first introduce a local model which allows to study velocity and buoyancy fluctuations in a Lagrangian domain periodically stretched and sheared by the tidal base flow. While keeping the key physical ingredients only, such a model is efficient to simulate planetary regimes where tidal amplitudes and dissipation are small. With this model, we prove that tidal flows are able to drive parametric subharmonic resonances of internal waves, in a way reminiscent of the elliptical instability in rotating fluids. The growth rates computed via Direct Numerical Simulations (DNS) are in very good agreement with WKB analysis and Floquet theory. We also investigate the turbulence driven by this instability mechanism. With spatio-temporal analysis, we show that it is a weak internal wave turbulence occurring at small Froude and buoyancy Reynolds numbers. When the gap between the excitation and the Brunt-V\\"ais\\"al\\"a frequencies is increased, the frequency spectrum of this wave turbulence displays a -2 power law reminiscent of the high-frequency branch of the Garett and Munk spectrum (Garrett & Munk 1979) which has been measured in the oceans. In addition, we find that the mixing efficiency is altered compared to what is computed in the context of DNS of stratified turbulence excited at small Froude and large buoyancy Reynolds numbers and is consistent with a superposition of waves.

  11. Electric field induced instabilities in free emulsion films

    Energy Technology Data Exchange (ETDEWEB)

    Tchoukov, P.; Dabros, T. [Natural Resources Canada, Devon, AB (Canada); Mostowfi, F. [Schlumberger DBR Technology Center, Edmonton, AB (Canada); Panchev, N. [Champion Technologies Inc., Houston, TX (United States); Czarnecki, J. [Alberta Univ., Edmonton, AB (Canada). Dept. of Chemical and Materials Engineering

    2009-07-01

    This presentation reported on a study that investigated the mechanism of electric field-induced breakdown of free emulsion films. Instability patterns were observed on the plane of a water-oil-water film following electric polarization. The length-scales of the instabilities were measured by analyzing images immediately after applying the electric field. Linear stability analysis was used to calculate the theoretical dominant wavelengths. The calculated values were found to be in good agreement with measured values. The films were formed in a thin film apparatus modified so that the oil film separated 2 aqueous phase compartments, each in contact with a platinum electrode. This enabled the measurement of disjoining pressure while applying the electric field to the film. It was concluded that breakdown of thin films induced by electric field has many applications, including electrostatic de-emulsification/desalination of crude oil and emulsion stability measurements. It was concluded that electroporation and dielectric breakdown may be responsible for electric field-induced breakdown. This study also presented evidence of an increase in electric field-induced instabilities in emulsion films resulting in rupture. tabs., figs.

  12. Parametric instabilities in magnetized bi-ion and dusty plasmas

    Indian Academy of Sciences (India)

    -ion or dusty plasma with parametric pumping of the magnetic field is analysed. The equation of motion governing the perturbed plasma is derived and parametrically excited transverse modes propagating along the magnetic field are found.

  13. Radiation Effects on the Thermodiffusive Instability of Premixed Flames on a Cylindrical Porous Flame Holder

    Science.gov (United States)

    Du, Minglong; Yang, Lijun

    2017-10-01

    A linear analysis method was used to investigate the mechanics of radiation heat loss and mass transfer in the porous wall of premixed annular flames and their effect on thermodiffusive instability. The dispersion relation between the disturbance wave growth rate and wavenumber was calculated numerically. Results showed that radiation heat loss elevated the annular flame slightly away from the porous wall. In the annular flame with small Lewis numbers, radiation heat loss changed the thermodiffusive instability from a pulsating to a cellular state, while for the large Lewis numbers, only the pulsating instability was represented. Increasing radiation heat loss and the radius of the porous wall enhanced the instability of the annular flames. Heat losses decreased with the continued increase in thickness of the porous wall and the decrease in porosity. Annular flames with long-wave mode along the angular direction were more unstable than the shortwave mode.

  14. ANALYTICAL SOLUTIONS FOR RADIATIVE TRANSFER: IMPLICATIONS FOR GIANT PLANET FORMATION BY DISK INSTABILITY

    International Nuclear Information System (INIS)

    Boss, Alan P.

    2009-01-01

    The disk instability mechanism for giant planet formation is based on the formation of clumps in a marginally gravitationally unstable protoplanetary disk, which must lose thermal energy through a combination of convection and radiative cooling if they are to survive and contract to become giant protoplanets. While there is good observational support for forming at least some giant planets by disk instability, the mechanism has become theoretically contentious, with different three-dimensional radiative hydrodynamics codes often yielding different results. Rigorous code testing is required to make further progress. Here we present two new analytical solutions for radiative transfer in spherical coordinates, suitable for testing the code employed in all of the Boss disk instability calculations. The testing shows that the Boss code radiative transfer routines do an excellent job of relaxing to and maintaining the analytical results for the radial temperature and radiative flux profiles for a spherical cloud with high or moderate optical depths, including the transition from optically thick to optically thin regions. These radial test results are independent of whether the Eddington approximation, diffusion approximation, or flux-limited diffusion approximation routines are employed. The Boss code does an equally excellent job of relaxing to and maintaining the analytical results for the vertical (θ) temperature and radiative flux profiles for a disk with a height proportional to the radial distance. These tests strongly support the disk instability mechanism for forming giant planets.

  15. Star formation through thermal instability of radiative plasma with finite electron inertia and finite Larmor radius corrections

    Energy Technology Data Exchange (ETDEWEB)

    Kaothekar, Sachin, E-mail: sackaothekar@gmail.com [Department of Physics, Mahakal Institute of Technology, Ujjain-456664, Madhya Pradesh (India)

    2016-08-15

    I have studied the effects of finite electron inertia, finite ion Larmor radius (FLR) corrections, and radiative heat-loss function on the thermal instability of an infinite homogeneous, viscous plasma incorporating the effect of thermal conductivity for star formation in interstellar medium (ISM). A general dispersion relation is derived using the normal mode analysis method with the help of relevant linearized perturbation equations of the problem. The wave propagation is discussed for longitudinal and transverse directions to the external magnetic field and the conditions of modified thermal instabilities and stabilities are discussed in different cases. We find that the thermal instability criterion is get modified into radiative instability criterion by inclusion of radiative heat-loss functions with thermal conductivity. The viscosity of medium removes the effect of FLR corrections from the condition of radiative instability. Numerical calculation shows stabilizing effect of heat-loss function, viscosity and FLR corrections, and destabilizing effect of finite electron inertia on the thermal instability. Results carried out in this paper shows that stars are formed in interstellar medium mainly due to thermal instability.

  16. Star formation through thermal instability of radiative plasma with finite electron inertia and finite Larmor radius corrections

    Directory of Open Access Journals (Sweden)

    Sachin Kaothekar

    2016-08-01

    Full Text Available I have studied the effects of finite electron inertia, finite ion Larmor radius (FLR corrections, and radiative heat-loss function on the thermal instability of an infinite homogeneous, viscous plasma incorporating the effect of thermal conductivity for star formation in interstellar medium (ISM. A general dispersion relation is derived using the normal mode analysis method with the help of relevant linearized perturbation equations of the problem. The wave propagation is discussed for longitudinal and transverse directions to the external magnetic field and the conditions of modified thermal instabilities and stabilities are discussed in different cases. We find that the thermal instability criterion is get modified into radiative instability criterion by inclusion of radiative heat-loss functions with thermal conductivity. The viscosity of medium removes the effect of FLR corrections from the condition of radiative instability. Numerical calculation shows stabilizing effect of heat-loss function, viscosity and FLR corrections, and destabilizing effect of finite electron inertia on the thermal instability. Results carried out in this paper shows that stars are formed in interstellar medium mainly due to thermal instability.

  17. Out-of-phase flashing induced instabilities in CIRCUS facility

    Energy Technology Data Exchange (ETDEWEB)

    Christian Pablo Marcel; Van der Hagen, T.H.J.J. [Interfaculty Reactor Institute, Delft University of Technology, Mekelweg 15, 2629 JB Delft (Netherlands)

    2005-07-01

    Full text of publication follows: Flashing-induced instabilities are very important during the startup phase of natural-circulation boiling water reactors. To study this type of instability an axial fully scaled facility named CIRCUS was constructed. Experiments at low power and low pressure (typical startup conditions) are carried out on this steam/water natural circulation loop with two parallel risers. A detailed measurement of the void-fraction profile is possible by using needle-probes and the use of glass tubes for the riser and core sections allow to use optical techniques for velocity measurements. The flashing and the mechanism of flashing-induced instabilities are analyzed paying special attention on the strong coupling effect between the two riser channels. It is clear from the experiments that the out-of-phase instability is much more susceptible to occur than the in-phase instability in a system with two parallel risers. The instability region is found as soon as the operational boundary between single-phase and two-phase operation is crossed. The relation between the period of the oscillations and the fluid transient time is also investigated. The stability map constructed using this experimental data is also discussed. (authors)

  18. Studies on the parametric decay of waves in fusion plasmas

    International Nuclear Information System (INIS)

    Paettikangas, T.

    1992-08-01

    Parametric instabilities of large-amplitude electromagnetic waves are investigated in fusion applications. In laser fusion, the electromegnetic wave reflected from the overdense plasma can act as a secondary pump wave and exite parametric instabilities. In double simulated Brilloun scattering (DSBS), both the incoming and the reflected pump wave scatter from a common ion sound wave. The stationary states and the dynamics of DSBS are investigated by using a simple envelope model. The ion sound wave that is exited in DSBS is shown to have soliton-like properties. The simulated Raman scattering (SRS) of free-electron-laser radiation can be applied to current drive in tokamaks. SRS generates fast longitudinal electron plasma waves which accelerate electrons to relativistic energies. Since the energetic current-carrying electrons are almost collisionless, the current decays very slowly. The feasibility of the Raman current drive in tokamaks is investigated theoretically. The current drive efficiency and the optimum free-electron-laser parameters are determined. The energy transfer to the fast electrons from the electrostatic wave is studied with relativistic Vlasov-Maxwell simulations. The parametric decay of a wave to half-harmonics is investigated. It is shown that the growth rate of the decay vanishes in the limit of a long wavelenght of the pump wave even for general electromagnetic or electrostatic decay models. The results are applied to the decay of a fast magnetosonic waves in tokamak plasmas. (orig.)

  19. Genomic instability and the role of radiation quality

    International Nuclear Information System (INIS)

    Kadhim, M. A.; Hill, M. A.; Moore, S. R.

    2006-01-01

    Genomic instability (GI) is a hallmark of tumorigenic progression and is observed as delayed genetic damage in the progeny of irradiated and unirradiated bystander cells. The expression of GI can be influenced by genotype, cell type and radiation quality. While several studies have demonstrated the induction of GI by high and low-linear energy transfer (LET) radiation, our work on human and mouse primary cell systems has shown LET-dependent differences in the induction and expression of GI. These differences might be attributed to differences in radiation track structure, dose rate, contribution of bystander cells and radiation dose. This paper reviews the role of radiation quality in the induction of GI and describe the possible mechanisms underlining the observed differences between radiation types on its induction. The experimental results presented suggest that dose might be the most significant factor in determining induction of GI after low-LET radiation. (authors)

  20. Substrate-induced instability in gas microstrip detectors

    International Nuclear Information System (INIS)

    Bateman, J.E.; Connolly, J.F.

    1992-12-01

    The results of a programme of research into substrate-induced gain instability in gas microstrip detectors are reported. Information has been collected on a wide range of substrates including many commonly available glasses and ceramics. A theoretical model of the gain instability is proposed. While we have not yet found an acceptable substrate for the construction of high flux detectors our experience points to electronically conductive glasses as the most promising source of a stable substrate. (Author)

  1. On physical and numerical instabilities arising in simulations of non-stationary radiatively cooling shocks

    Science.gov (United States)

    Badjin, D. A.; Glazyrin, S. I.; Manukovskiy, K. V.; Blinnikov, S. I.

    2016-06-01

    We describe our modelling of the radiatively cooling shocks and their thin shells with various numerical tools in different physical and calculational setups. We inspect structure of the dense shell, its formation and evolution, pointing out physical and numerical factors that sustain its shape and also may lead to instabilities. We have found that under certain physical conditions, the circular shaped shells show a strong bending instability and successive fragmentation on Cartesian grids soon after their formation, while remain almost unperturbed when simulated on polar meshes. We explain this by physical Rayleigh-Taylor-like instabilities triggered by corrugation of the dense shell surfaces by numerical noise. Conditions for these instabilities follow from both the shell structure itself and from episodes of transient acceleration during re-establishing of dynamical pressure balance after sudden radiative cooling onset. They are also easily excited by physical perturbations of the ambient medium. The widely mentioned non-linear thin shell instability, in contrast, in tests with physical perturbations is shown to have only limited chances to develop in real radiative shocks, as it seems to require a special spatial arrangement of fluctuations to be excited efficiently. The described phenomena also set new requirements on further simulations of the radiatively cooling shocks in order to be physically correct and free of numerical artefacts.

  2. The genetics of radiation-induced and sporadic osteosarcoma: a unifying theory?

    International Nuclear Information System (INIS)

    Rosemann, Michael; Kuosaite, Virginija; Nathrath, Michaela; Atkinson, Michael J.

    2002-01-01

    Cancer is a disease of the genome, with the neoplastic phenotype being passed from one cell generation to the other. Radiation-induced cancer has often been considered to represent a unique entity amongst neoplasia, with the energy deposition being held responsible for both direct (gene mutations) and indirect (bystander effects, induced instability etc) alterations to the cellular genome. However, radiogenic tumours in man and experimental animals appear to be physiologically and genetically indistinguishable from their sporadic counterparts, suggesting that the aetiologies of these two tumour types are in fact closely related. We have conducted a general screen of the genetic alterations in radiation-induced mouse osteosarcoma, a tumour that is histopathologically indistinguishable from human sporadic osteosarcoma. Comparison of the two tumour types indicates the existence of a common set of genetic changes, providing additional evidence to support the concept that the molecular pathology of radiation-induced malignancy is no different to that of sporadic cancers. (author)

  3. Dynamics of polaritons in semiconductor microcavities near instability thresholds

    International Nuclear Information System (INIS)

    He, Peng-Bin

    2012-01-01

    A theoretical study is presented on the dynamics of polaritons in semiconductor microcavities near parametric instability thresholds. With upward or downward ramp of optical pump, different instability modes emerge in parameter space defined by damping and detuning. According to these modes, stationary short-wave, stationary periodic, oscillatory periodic, and oscillatory uniform parametric instabilities are distinguished. By multiple scale expansion, the dynamics near threshold can be described by a critical mode with a slowly varying amplitude for the last three instabilities. Furthermore, it is found that the evolutions of their amplitudes are governed by real or complex Ginzburg–Landau equations. -- Highlights: ► Phase diagrams for different instability in extended parameter space. ► Different instability modes near thresholds. ► Different envelop equations near thresholds obtained by multi-scale expansion.

  4. Delayed cell death, giant cell formation and chromosome instability induced by X-irradiation in human embryo cells

    International Nuclear Information System (INIS)

    Roy, K.; Kodama, Seiji; Suzuki, Keiji; Watanabe, Masami

    1999-01-01

    We studied X-ray-induced delayed cell death, delayed giant cell formation and delayed chromosome aberrations in normal human embryo cells to explore the relationship between initial radiation damage and delayed effect appeared at 14 to 55 population doubling numbers (PDNs) after X-irradiation. The delayed effect was induced in the progeny of X-ray survivors in a dose-dependent manner and recovered with increasing PDNs after X-irradiation. Delayed plating for 24 h post-irradiation reduced both acute and delayed lethal damage, suggesting that potentially lethal damage repair (PLDR) can be effective for relieving the delayed cell death. The chromosome analysis revealed that most of the dicentrics (more than 90%) observed in the progeny of X-ray survivors were not accompanied with fragments, in contrast with those observed in the first mitosis after X-irradiation. The present results indicate that the potentiality of genetic instability is determined during the repair process of initial radiation damage and suggest that the mechanism for formation of delayed chromosome aberrations by radiation might be different from that of direct radiation-induced chromosome aberrations. (author)

  5. Interaction of a parametric transducer with a resonant bar gravitational radiation detector

    International Nuclear Information System (INIS)

    Linthorne, N.P.; Veitch, P.J.; Blair, D.G.

    1990-01-01

    It is shown that a microwave parametric transducer for a resonant bar gravitational radiation antenna can achieve high electromechanical coupling without degrading the acoustic Q of the antenna. The reactive coupling of the transducer to the antenna leads to both cold-damping and modification of the antenna's resonant frequency. These effects are examined in a 1.5 tonne niobium resonant bar antenna. At low coupling the observed behaviour is found to be in good agreement with theory. At higher coupling, the behaviour is complicated by other effects. We discuss how these parametric effects may be used to advantage when suitably controlled. (author)

  6. Effect of magnetic field and radiative condensation on the Jeans instability of dusty plasma with polarization force

    International Nuclear Information System (INIS)

    Prajapati, R.P.

    2013-01-01

    The Jeans instability of self-gravitating dusty plasma with polarization force is investigated considering the effects of magnetic field, dust temperature and radiative condensation. The condition of Jeans instability and expression of critical Jeans wave number are obtained which depend upon polarization force and dust temperature but these are unaffected by the presence of magnetic field. The radiative heat-loss functions also modify the Jeans condition of instability and expression of critical Jeans wave number. It is observed that the polarization force and ratio of radiative heat-loss functions have destabilizing while magnetic field and dust temperature have stabilizing influence on the growth rate of Jeans instability.

  7. Instability induced by cross-diffusion in reaction-diffusion systems

    DEFF Research Database (Denmark)

    Tian, Canrong; Lin, Zhigui; Pedersen, Michael

    2010-01-01

    In this paper the instability of the uniform equilibrium of a general strongly coupled reaction–diffusion is discussed. In unbounded domain and bounded domain the sufficient conditions for the instability are obtained respectively. The conclusion is applied to the ecosystem, it is shown that cros...... can induce the instability of an equilibrium which is stable for the kinetic system and for the self-diffusion–reaction system.......In this paper the instability of the uniform equilibrium of a general strongly coupled reaction–diffusion is discussed. In unbounded domain and bounded domain the sufficient conditions for the instability are obtained respectively. The conclusion is applied to the ecosystem, it is shown that cross-diffusion...

  8. Outflow-Induced Dynamical and Radiative Instability in Stellar Envelopes with an Application to Luminous Blue Variables and Wolf-Rayet Stars

    Science.gov (United States)

    Stothers, Richard B.; Hansen, James E. (Technical Monitor)

    2002-01-01

    Theoretical models of the remnants of massive stars in a very hot, post-red-supergiant phase display no obvious instability if standard assumptions are made. However, the brightest observed classical luminous blue variables (LBVs) may well belong to such a phase. A simple time-dependent theory of moving stellar envelopes is developed in order to treat deep hydrodynamical disturbances caused by surface mass loss and to test the moving envelopes for dynamical instability. In the case of steady-state outflow, the theory reduces to the equivalent of the Castor, Abbott, and Klein formulation for optically thick winds at distances well above the sonic point. The time-dependent version indicates that the brightest and hottest LBVs are both dynamically and radiatively unstable, as a result of the substantial lowering of the generalized Eddington luminosity limit by the mass-loss acceleration. It is suggested that dynamical instability, by triggering secular cycles of mass loss, is primarily what differentiates LBVs from the purely radiatively unstable Wolf-Rayet stars. Furthermore, when accurate main-sequence mass-loss rates are used to calculate the evolutionary tracks, the predicted surface hydrogen and nitrogen abundances of the blue remnants agree much better with observations of the brightest LBVs than before.

  9. Ionising radiation and trans-generational instability

    International Nuclear Information System (INIS)

    Vrhovac, I.; Niksic, G.

    2007-01-01

    Indirect monitoring of the impact posed by ionising radiation to the genome instability of the descendants, consequent to the irradiation of one of their parents, boils down to the investigation of changes occurring exclusively in the mini-satellite loci of the cells constituting the gametal developmental line. The resultant mini-satellite mutations are expressed in their percentages, and equal to the ratio of the number of mutated alleles in that particular generation over the total number of alleles present. The impact of ionising radiation to the irradiated parent's offspring was first noticed on haematopoietic mouse stem-cells. Even though an irradiated cell of a female parent lacks any mutations whatsoever, daughter cells present with the increased mutation rates. The observed phenomenon of the so called trans-generational instability has been defined as the occurrence of mutations in the genome of individuals originating from the irradiated ancestors. Due to the aforementioned, one can conclude that these mutations need not be present in the irradiated parental cells, and do not necessarily vanish in the next few generations, but may result in the increase in mutation rates observed in the latter. The results of the investigations performed on the animal model, as well as of those carried out in human population, point to the occurrence of significant changes to be found on mini-satellite loci of the descending generation, while the mechanism underlying those changes hasn't been completely clarified yet, and, therefore, calls for the further investigation. (author)

  10. Effect of the thermal spread in a beam on the radiative Pierce instability

    International Nuclear Information System (INIS)

    Klochkov, D.N.; Pekar, M.Yu.; Rukhadze, A.A.

    1999-01-01

    The linear dynamics of the radiative Pierce instability in a single plane in the case of the relativistic electron beam with T temperature stabilized through a strong magnetic field, is considered. It is shown that the instability increment decreases with the thermal spread growth [ru

  11. Causes of genome instability

    DEFF Research Database (Denmark)

    Langie, Sabine A S; Koppen, Gudrun; Desaulniers, Daniel

    2015-01-01

    function, chromosome segregation, telomere length). The purpose of this review is to describe the crucial aspects of genome instability, to outline the ways in which environmental chemicals can affect this cancer hallmark and to identify candidate chemicals for further study. The overall aim is to make......Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome's integrity, whether as a consequence of inherited defects or induced via exposure to environmental agents (chemicals, biological agents and radiation). Thus...

  12. Radiation-induced colon cancer with high frequency microsatellite instability (MSI-H), report of a case

    International Nuclear Information System (INIS)

    Arai, Masami; Ueno, Masashi; Koizumi, Koichi

    2002-01-01

    We report a 67-year-old female with radiation-induced colon cancer which developed 23 years after radiation therapy for cancer of the endometrium. She was strongly suspected to be a case of hereditary nonpolyposis colorectal cancer (HNPCC) due to her clinical manifestations, i.e. metachronous multiple cancer developed in the endometrium and colon. MSI test and immunohistochemistry for mismatch repair (MMR) proteins revealed that MSI was highly positive and expression of hMSH2 was lost in the colon cancers. Further, on examining the genetic change, the point mutation, ACG→ATG, responsible for amino acid change, was detected in codon8 (exon1) of the hMSH2 gene. The change, however, could be a polymorphism of this gene and further analyses were necessitated to confirm the genetic background for HNPCC. Interestingly, three cancers with adenoma were located in the mucosa of radiation colitis, in which several atypical glands were also found. This is the only case of radiation-induced colorectal cancer with MSI-H in our hospital. Because of our previous studies, we believe that the genetic pathway in carcinogenesis of the radiation-induced colon cancer is different from that of HNPCC, despite their having several kinds of clinical and pathological features in common. (author)

  13. Radiation-induced colon cancer with high frequency microsatellite instability (MSI-H), report of a case

    Energy Technology Data Exchange (ETDEWEB)

    Arai, Masami; Ueno, Masashi; Koizumi, Koichi [Japanese Foundation for Cancer Research, Tokyo (Japan). Hospital] [and others

    2002-07-01

    We report a 67-year-old female with radiation-induced colon cancer which developed 23 years after radiation therapy for cancer of the endometrium. She was strongly suspected to be a case of hereditary nonpolyposis colorectal cancer (HNPCC) due to her clinical manifestations, i.e. metachronous multiple cancer developed in the endometrium and colon. MSI test and immunohistochemistry for mismatch repair (MMR) proteins revealed that MSI was highly positive and expression of hMSH2 was lost in the colon cancers. Further, on examining the genetic change, the point mutation, ACG{yields}ATG, responsible for amino acid change, was detected in codon8 (exon1) of the hMSH2 gene. The change, however, could be a polymorphism of this gene and further analyses were necessitated to confirm the genetic background for HNPCC. Interestingly, three cancers with adenoma were located in the mucosa of radiation colitis, in which several atypical glands were also found. This is the only case of radiation-induced colorectal cancer with MSI-H in our hospital. Because of our previous studies, we believe that the genetic pathway in carcinogenesis of the radiation-induced colon cancer is different from that of HNPCC, despite their having several kinds of clinical and pathological features in common. (author)

  14. A novel strategy to identify the critical conditions for growth-induced instabilities.

    Science.gov (United States)

    Javili, A; Steinmann, P; Kuhl, E

    2014-01-01

    Geometric instabilities in living structures can be critical for healthy biological function, and abnormal buckling, folding, or wrinkling patterns are often important indicators of disease. Mathematical models typically attribute these instabilities to differential growth, and characterize them using the concept of fictitious configurations. This kinematic approach toward growth-induced instabilities is based on the multiplicative decomposition of the total deformation gradient into a reversible elastic part and an irreversible growth part. While this generic concept is generally accepted and well established today, the critical conditions for the formation of growth-induced instabilities remain elusive and poorly understood. Here we propose a novel strategy for the stability analysis of growing structures motivated by the idea of replacing growth by prestress. Conceptually speaking, we kinematically map the stress-free grown configuration onto a prestressed initial configuration. This allows us to adopt a classical infinitesimal stability analysis to identify critical material parameter ranges beyond which growth-induced instabilities may occur. We illustrate the proposed concept by a series of numerical examples using the finite element method. Understanding the critical conditions for growth-induced instabilities may have immediate applications in plastic and reconstructive surgery, asthma, obstructive sleep apnoea, and brain development. © 2013 Elsevier Ltd. All rights reserved.

  15. Ablative stabilization of Rayleigh-Taylor instabilities resulting from a laser-driven radiative shock

    Science.gov (United States)

    Huntington, C. M.; Shimony, A.; Trantham, M.; Kuranz, C. C.; Shvarts, D.; Di Stefano, C. A.; Doss, F. W.; Drake, R. P.; Flippo, K. A.; Kalantar, D. H.; Klein, S. R.; Kline, J. L.; MacLaren, S. A.; Malamud, G.; Miles, A. R.; Prisbrey, S. T.; Raman, K. S.; Remington, B. A.; Robey, H. F.; Wan, W. C.; Park, H.-S.

    2018-05-01

    The Rayleigh-Taylor (RT) instability is a common occurrence in nature, notably in astrophysical systems like supernovae, where it serves to mix the dense layers of the interior of an exploding star with the low-density stellar wind surrounding it, and in inertial confinement fusion experiments, where it mixes cooler materials with the central hot spot in an imploding capsule and stifles the desired nuclear reactions. In both of these examples, the radiative flux generated by strong shocks in the system may play a role in partially stabilizing RT instabilities. Here, we present experiments performed on the National Ignition Facility, designed to isolate and study the role of radiation and heat conduction from a shock front in the stabilization of hydrodynamic instabilities. By varying the laser power delivered to a shock-tube target with an embedded, unstable interface, the radiative fluxes generated at the shock front could be controlled. We observe decreased RT growth when the shock significantly heats the medium around it, in contrast to a system where the shock did not produce significant heating. Both systems are modeled with a modified set of buoyancy-drag equations accounting for ablative stabilization, and the experimental results are consistent with ablative stabilization when the shock is radiative. This result has important implications for our understanding of astrophysical radiative shocks and supernova radiative hydrodynamics [Kuranz et al., Nature Communications 9(1), 1564 (2018)].

  16. Radiation-induced genomic instability driven by de novo chromosomal rearrangement hot spots

    International Nuclear Information System (INIS)

    Grosovsky, A.J.; Allen, R.N.; Moore, S.R.

    2003-01-01

    Genomic instability has become generally recognized as a critical contributor to tumor progression by generating the necessary number of genetic alterations required for expression of a clinically significant malignancy. Our study of chromosomal instability investigates the hypothesis that chromosomal rearrangements can generate novel breakage-prone sites, resulting in instability acting predominantly in cis. Here we present an analysis of the karyotypic distribution of instability associated chromosomal rearrangements in TK6 and derivative human lymphoblasts. Karyotypic analysis performed on a total of 455 independent clones included 183 rearrangements distributed among 100 separate unstable clones. The results demonstrate that the breakpoints of chromosomal rearrangements in unstable clones are non-randomly distributed throughout the genome. This pattern is statistically significant, and incompatible with expectations for random breakage associated with loss or alteration of a trans-acting factor. Furthermore, specific chromosomal breakage hot spots associated with instability have been identified; these occur in several independent unstable clones and are often repeatedly broken and rejoined during the outgrowth of an individual clone. In complimentary studies, genomic instability was generated without any exposure to a DNA-damaging agent, but rather by transfection with alpha heterochromatin DNA. In a prospective analysis, human-hamster hybrid AL cells containing a single human chromosome 11 were transfected with heterochromatic alpha DNA repeats and clones were analyzed by chromosome 11 painting. Transfection with alpha DNA was associated with karyotypic heterogeneity in 40% of clones examined; control transfections with plasmid alone did not lead to karyotypic heterogeneity

  17. Two-parametric model of electron beam in computational dosimetry for radiation processing

    International Nuclear Information System (INIS)

    Lazurik, V.M.; Lazurik, V.T.; Popov, G.; Zimek, Z.

    2016-01-01

    Computer simulation of irradiation process of various materials with electron beam (EB) can be applied to correct and control the performances of radiation processing installations. Electron beam energy measurements methods are described in the international standards. The obtained results of measurements can be extended by implementation computational dosimetry. Authors have developed the computational method for determination of EB energy on the base of two-parametric fitting of semi-empirical model for the depth dose distribution initiated by mono-energetic electron beam. The analysis of number experiments show that described method can effectively consider random displacements arising from the use of aluminum wedge with a continuous strip of dosimetric film and minimize the magnitude uncertainty value of the electron energy evaluation, calculated from the experimental data. Two-parametric fitting method is proposed for determination of the electron beam model parameters. These model parameters are as follow: E 0 – energy mono-energetic and mono-directional electron source, X 0 – the thickness of the aluminum layer, located in front of irradiated object. That allows obtain baseline data related to the characteristic of the electron beam, which can be later on applied for computer modeling of the irradiation process. Model parameters which are defined in the international standards (like E p – the most probably energy and R p – practical range) can be linked with characteristics of two-parametric model (E 0 , X 0 ), which allows to simulate the electron irradiation process. The obtained data from semi-empirical model were checked together with the set of experimental results. The proposed two-parametric model for electron beam energy evaluation and estimation of accuracy for computational dosimetry methods on the base of developed model are discussed. - Highlights: • Experimental and computational methods of electron energy evaluation. • Development

  18. Faraday instability of crystallization waves in 4He

    International Nuclear Information System (INIS)

    Abe, H; Ueda, T; Morikawa, M; Saitoh, Y; Nomura, R; Okuda, Y

    2007-01-01

    Periodic modulation of the gravity acceleration makes a flat surface of a fluid unstable and standing waves are parametrically excited on the surface. This phenomenon is called Faraday instability. Since a crystal-superfluid interface of 4 He at low temperatures is very mobile and behaves like a fluid surface, Saarloos and Weeks predicted that Faraday instability of the crystallization waves exists in 4 He and that the threshold excitation for the instability depends on the crystal growth coefficient. We successfully observed the Faraday instability of the crystal-liquid interface at 160 mK. Faraday waves were parametrically generated at one half of the driving frequency 90 Hz. Amplitude of the Faraday wave becomes smaller at higher temperature due to decrease of the crystal growth coefficient and disappears above 200 mK

  19. Simulating Space Radiation-Induced Breast Tumor Incidence Using Automata.

    Science.gov (United States)

    Heuskin, A C; Osseiran, A I; Tang, J; Costes, S V

    2016-07-01

    Estimating cancer risk from space radiation has been an ongoing challenge for decades primarily because most of the reported epidemiological data on radiation-induced risks are derived from studies of atomic bomb survivors who were exposed to an acute dose of gamma rays instead of chronic high-LET cosmic radiation. In this study, we introduce a formalism using cellular automata to model the long-term effects of ionizing radiation in human breast for different radiation qualities. We first validated and tuned parameters for an automata-based two-stage clonal expansion model simulating the age dependence of spontaneous breast cancer incidence in an unexposed U.S. We then tested the impact of radiation perturbation in the model by modifying parameters to reflect both targeted and nontargeted radiation effects. Targeted effects (TE) reflect the immediate impact of radiation on a cell's DNA with classic end points being gene mutations and cell death. They are well known and are directly derived from experimental data. In contrast, nontargeted effects (NTE) are persistent and affect both damaged and undamaged cells, are nonlinear with dose and are not well characterized in the literature. In this study, we introduced TE in our model and compared predictions against epidemiologic data of the atomic bomb survivor cohort. TE alone are not sufficient for inducing enough cancer. NTE independent of dose and lasting ∼100 days postirradiation need to be added to accurately predict dose dependence of breast cancer induced by gamma rays. Finally, by integrating experimental relative biological effectiveness (RBE) for TE and keeping NTE (i.e., radiation-induced genomic instability) constant with dose and LET, the model predicts that RBE for breast cancer induced by cosmic radiation would be maximum at 220 keV/μm. This approach lays the groundwork for further investigation into the impact of chronic low-dose exposure, inter-individual variation and more complex space radiation

  20. Three-dimensional Langmuir wave instabilities in type III solar radio bursts

    International Nuclear Information System (INIS)

    Bardwell, S.; Goldman, M.V.

    1976-01-01

    Assuming that type III solar radio bursts are associated with electron streams moving at about c/3, Langmuir waves should be strongly excited. We have studied all of the Langmuir-wave linear parametric instabilities excited in cylindrical symmetry by an electron-stream--driven Langmuir wave-pump propagating along the stream axis. Included in this unified homogeneous treatment are induced backscattering off ions, the oscillating two-stream instability, and a new ''stimulated modulational instability,'' previously unconsidered in this context. Near a few solar radii, the latter two deposit Langmuir wave energy into a forward-scattering cone about the stream axis. It is concluded that the linear stage of the forward-scattering instabilities involves transfer of energy to Langmuir waves which remain in resonance with the stream, and therefore probably do not prevent rapid depletion of the electron stream due to quasilinear plateau formation at these distances from the Sun

  1. Significance of genetic predisposition and genomic instability for individual sensitivity to radiation. Implications for radiation protection

    International Nuclear Information System (INIS)

    Heller, H.

    2001-01-01

    At its closed-door meeting on 20/21 January 2000 the Radiation Protection Committee dedicated much of its attention to the significance of genetic predisposition and genetic instability for individual radiation sensitivity and to the implication of this for radiation protection. The statements and contributions to the closing plenary discussion touched on many aspects of ethics, personal rights, occupational medicine and insurance issues relating to this subject, all of which extend far beyond the purely technical issues of radiation protection. The present volume contains the lecture manuscripts of the meeting as well as a summarising assessment by the Radiation Protection Committee [de

  2. Untargeted effects of ionizing radiation: Implications for radiation pathology

    International Nuclear Information System (INIS)

    Wright, Eric G; Coates, Philip J

    2006-01-01

    The dogma that genetic alterations are restricted to directly irradiated cells has been challenged by observations in which effects of ionizing radiation, characteristically associated with the consequences of energy deposition in the cell nucleus, arise in non-irradiated cells. These, so called, untargeted effects are demonstrated in cells that have received damaging signals produced by irradiated cells (radiation-induced bystander effects) or that are the descendants of irradiated cells (radiation-induced genomic instability). Radiation-induced genomic instability is characterized by a number of delayed adverse responses including chromosomal abnormalities, gene mutations and cell death. Similar effects, as well as responses that may be regarded as protective, have been attributed to bystander mechanisms. Whilst the majority of studies to date have used in vitro systems, some adverse non-targeted effects have been demonstrated in vivo. However, at least for haemopoietic tissues, radiation-induced genomic instability in vivo may not necessarily be a reflection of genomically unstable cells. Rather the damage may reflect responses to ongoing production of damaging signals; i.e. bystander responses, but not in the sense used to describe the rapidly induced effects resulting from direct interaction of irradiated and non-irradiated cells. The findings are consistent with a delayed and long-lived tissue reaction to radiation injury characteristic of an inflammatory response with the potential for persisting bystander-mediated damage. An important implication of the findings is that contrary to conventional radiobiological dogma and interpretation of epidemiologically-based risk estimates, ionizing radiation may contribute to malignancy and particularly childhood leukaemia by promoting initiated cells rather than being the initiating agent. Untargeted mechanisms may also contribute to other pathological consequences

  3. Signaling pathways underpinning the manifestations of ionizing radiation-induced bystander effects.

    Science.gov (United States)

    Hamada, Nobuyuki; Maeda, Munetoshi; Otsuka, Kensuke; Tomita, Masanori

    2011-06-01

    For nearly a century, ionizing radiation has been indispensable to medical diagnosis. Furthermore, various types of electromagnetic and particulate radiation have also been used in cancer therapy. However, the biological mechanism of radiation action remains incompletely understood. In this regard, a rapidly growing body of experimental evidence indicates that radiation exposure induces biological effects in cells whose nucleus has not been irradiated. This phenomenon termed the 'non-targeted effects' challenges the long-held tenet that radiation traversal through the cell nucleus is a prerequisite to elicit genetic damage and biological responses. The non-targeted effects include biological effects in cytoplasm-irradiated cells, bystander effects that arise in non-irradiated cells having received signals from irradiated cells, and genomic instability occurring in the progeny of irradiated cells. Such non-targeted responses are interrelated, and the bystander effect is further related with an adaptive response that manifests itself as the attenuated stressful biological effects of acute high-dose irradiation in cells that have been pre-exposed to low-dose or low-dose-rate radiation. This paper reviews the current body of knowledge about the bystander effect with emphasis on experimental approaches, in vitro and in vivo manifestations, radiation quality dependence, temporal and spatial dependence, proposed mechanisms, and clinical implications. Relations of bystander responses with the effects in cytoplasm-irradiated cells, genomic instability and adaptive response will also be briefly discussed.

  4. Chaotic parametric soliton-like pulses in ferromagnetic-film active ring resonators

    International Nuclear Information System (INIS)

    Grishin, S. V.; Golova, T. M.; Morozova, M. A.; Romanenko, D. V.; Seleznev, E. P.; Sysoev, I. V.; Sharaevskii, Yu. P.

    2015-01-01

    The generation of quasi-periodic sequences of parametric soliton-like pulses in an active ring resonator with a ferromagnetic film via the three-wave parametric instability of a magnetostatic surface wave is studied theoretically and experimentally. These dissipative structures form in time due to the competition between the cubic nonlinearity caused by parametric coupling between spin waves and the time dispersion caused by the resonant cavity that is present in a self-oscillatory system. The development of dynamic chaos due to the parametric instability of a magnetostatic surface wave results in irregular behavior of a phase. However, this behavior does not break a quasi-periodic pulse sequence when the gain changes over a wide range. The generated soliton-like pulses have a chaotic nature, which is supported by the maximum Lyapunov exponent estimated from experimental time series

  5. Analysis of beam transverse instability in electron linac

    International Nuclear Information System (INIS)

    Mondrus, I.N.; Shenderovich, A.M.

    1990-01-01

    Dispersion equations describing transverse beam instability in a single resonator section and in an accelerator comprising a sequence of resonator sections are derived. It is shown that close to parametric resonance of any multiplicity a reduction of cumulative instability incoherent takes place between nonsymmetric defocusing wave frequency and the frequency of accelerator cluster transport. Under exact resonance the increment equals to zero and under misalignment due to resonance depending on its sign and disturbance frequency an instability of either fast or slow wave takes place. It is shown that this effect leads to beam instability suppression of sections with the opposite sign of misalignment due to resonance are located in turn. The results obtained show that application of a parametric resonance through reducing slight the single section absolute instability threshold current, allows one to effectively suppress cumulative instability. The requirement to the accuracy of tuning to a resonance of identical sections is substantially reduced under the alternation of sections with different sign misalignment due to resonance and can be easily realized in practice

  6. Vanguards of paradigm shift in radiation biology. Radiation-induced adaptive and bystander responses

    International Nuclear Information System (INIS)

    Matsumoto, Hideki; Hamada, Nobuyuki; Kobayashi, Yasuhiko; Takahashi, Akihisa; Ohnishi, Takeo

    2007-01-01

    The risks of exposure to low dose ionizing radiation (below 100 mSv) are estimated by extrapolating from data obtained after exposure to high dose radiation, using a linear no-threshold model (LNT model). However, the validity of using this dose-response model is controversial because evidence accumulated over the past decade has indicated that living organisms, including humans, respond differently to low dose/low dose-rate radiation than they do to high dose/high dose-rate radiation. In other words, there are accumulated findings which cannot be explained by the classical ''target theory'' of radiation biology. The radioadaptive response, radiation-induced bystander effects, low-dose radio-hypersensitivity, and genomic instability are specifically observed in response to low dose/low dose-rate radiation, and the mechanisms underlying these responses often involve biochemical/molecular signals that respond to targeted and non-targeted events. Recently, correlations between the radioadaptive and bystander responses have been increasingly reported. The present review focuses on the latter two phenomena by summarizing observations supporting their existence, and discussing the linkage between them from the aspect of production of reactive oxygen and nitrogen species. (author)

  7. Parametric wave penetration through an overdense plasma layer

    International Nuclear Information System (INIS)

    Gradov, O.M.; Suender, D.

    1981-01-01

    The nonlinear penetration of an electromagnetic wave through an overdense plasma layer due to the excitation of parametric instabilities is studied. The quasistatic h.f. surface wave and the ion-acoustic wave, both parametrically growing, generate a nonlinear current which also exist beyound the linear skin length of the incident electromagnetic wave. This current leads to an exponential amplification of the electromagnetic wave amplitude in the layer. The growth rate of this process depends on the overthreshold value of the external wave intensity and the thickness of the layer. The saturation level of the transmitted wave amplitude is estimated for the case, when the instabilities are stabilized by generation of ion-acoustic harmonics. (author)

  8. Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation

    International Nuclear Information System (INIS)

    Suzuki, Keiji; Kodama, Seiji; Watanabe, Masami

    2010-01-01

    Ionizing radiation induces delayed destabilization of the genome in the progenies of surviving cells. This phenomenon, which is called radiation-induced genomic instability, is manifested by delayed induction of radiation effects, such as cell death, chromosome aberration, and mutation in the progeny of cells surviving radiation exposure. Previously, there was a report showing that delayed cell death was absent in Ku80-deficient Chinese hamster ovary (CHO) cells, however, the mechanism of their defect has not been determined. We found that delayed induction of DNA double strand breaks and chromosomal breaks were intact in Ku80-deficient cells surviving X-irradiation, whereas there was no sign for the production of chromosome bridges between divided daughter cells. Moreover, delayed induction of dicentric chromosomes was significantly compromised in those cells compared to the wild-type CHO cells. Reintroduction of the human Ku86 gene complimented the defective DNA repair and recovered delayed induction of dicentric chromosomes and delayed cell death, indicating that defective Ku80-dependent dicentric induction was the cause of the absence of delayed cell death. Since DNA-PKcs-defective cells showed delayed phenotypes, Ku80-dependent illegitimate rejoining is involved in delayed impairment of the integrity of the genome in radiation-survived cells.

  9. Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Keiji, E-mail: kzsuzuki@nagasaki-u.ac.jp [Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523 (Japan); Kodama, Seiji [Research Institute for Advanced Science and Technology, Osaka Prefecture University, 1-2 Gakuen-machi, Sakai 599-8570 (Japan); Watanabe, Masami [Kyoto University Research Reactor Institute, Kumatori-cho Sennan-gun, Osaka 590-0494 (Japan)

    2010-01-05

    Ionizing radiation induces delayed destabilization of the genome in the progenies of surviving cells. This phenomenon, which is called radiation-induced genomic instability, is manifested by delayed induction of radiation effects, such as cell death, chromosome aberration, and mutation in the progeny of cells surviving radiation exposure. Previously, there was a report showing that delayed cell death was absent in Ku80-deficient Chinese hamster ovary (CHO) cells, however, the mechanism of their defect has not been determined. We found that delayed induction of DNA double strand breaks and chromosomal breaks were intact in Ku80-deficient cells surviving X-irradiation, whereas there was no sign for the production of chromosome bridges between divided daughter cells. Moreover, delayed induction of dicentric chromosomes was significantly compromised in those cells compared to the wild-type CHO cells. Reintroduction of the human Ku86 gene complimented the defective DNA repair and recovered delayed induction of dicentric chromosomes and delayed cell death, indicating that defective Ku80-dependent dicentric induction was the cause of the absence of delayed cell death. Since DNA-PKcs-defective cells showed delayed phenotypes, Ku80-dependent illegitimate rejoining is involved in delayed impairment of the integrity of the genome in radiation-survived cells.

  10. Electromagnetic interference-induced instability in CPP-GMR read heads

    International Nuclear Information System (INIS)

    Khunkitti, P.; Siritaratiwat, A.; Kaewrawang, A.; Mewes, T.; Mewes, C.K.A.; Kruesubthaworn, A.

    2016-01-01

    Electromagnetic interference (EMI) has been a significant issue for the current perpendicular-to-the-plane giant magnetoresistance (CPP-GMR) read heads because it can cause magnetic failure. Furthermore, the magnetic noise induced by the spin transfer torque (STT) effect has played an important role in the CPP read heads because it can affect the stability of the heads. Accordingly, this work proposed an investigation of the magnetic instabilities induced by EMI through the STT effect in a CPP-GMR read head via micromagnetic simulations. The magnetization fluctuation caused by EMI was examined, and then, magnetic noise was evaluated by using power spectral density analysis. It was found that the magnetization orientation can be fluctuated by EMI in close proximity to the head. The results also showed a multimode spectral density. The main contributions of the spectral density were found to originate at the edges of the stripe height sides due to the characteristics of the demagnetization field inside the free layer. Hence, the magnetic instabilities produced by EMI become a significant factor that essentially impacts the reliability of the CPP-GMR read heads. - Highlights: • The instability induced by electromagnetic interference in read head is examined. • The magnetization orientation can be fluctuated by electromagnetic interference. • The electromagnetic interference can induce additional noise spectra to the system. • The noise is mainly located at stripe height of the read head. • The noise induced by electromagnetic interference is a crucial factor for the head.

  11. Electromagnetic interference-induced instability in CPP-GMR read heads

    Energy Technology Data Exchange (ETDEWEB)

    Khunkitti, P.; Siritaratiwat, A.; Kaewrawang, A. [KKU-Seagate Cooperation Research Laboratory, Department of Electrical Engineering, Faculty of Engineering, Khon Kaen University, Khon Kaen 40002 (Thailand); Mewes, T.; Mewes, C.K.A. [Department of Physics and Astronomy, MINT Center, University of Alabama, Tuscaloosa, AL 35487 (United States); Kruesubthaworn, A., E-mail: anankr@kku.ac.th [KKU-Seagate Cooperation Research Laboratory, Department of Electrical Engineering, Faculty of Engineering, Khon Kaen University, Khon Kaen 40002 (Thailand)

    2016-08-15

    Electromagnetic interference (EMI) has been a significant issue for the current perpendicular-to-the-plane giant magnetoresistance (CPP-GMR) read heads because it can cause magnetic failure. Furthermore, the magnetic noise induced by the spin transfer torque (STT) effect has played an important role in the CPP read heads because it can affect the stability of the heads. Accordingly, this work proposed an investigation of the magnetic instabilities induced by EMI through the STT effect in a CPP-GMR read head via micromagnetic simulations. The magnetization fluctuation caused by EMI was examined, and then, magnetic noise was evaluated by using power spectral density analysis. It was found that the magnetization orientation can be fluctuated by EMI in close proximity to the head. The results also showed a multimode spectral density. The main contributions of the spectral density were found to originate at the edges of the stripe height sides due to the characteristics of the demagnetization field inside the free layer. Hence, the magnetic instabilities produced by EMI become a significant factor that essentially impacts the reliability of the CPP-GMR read heads. - Highlights: • The instability induced by electromagnetic interference in read head is examined. • The magnetization orientation can be fluctuated by electromagnetic interference. • The electromagnetic interference can induce additional noise spectra to the system. • The noise is mainly located at stripe height of the read head. • The noise induced by electromagnetic interference is a crucial factor for the head.

  12. p53-Dependent suppression of genome instability in germ cells

    Energy Technology Data Exchange (ETDEWEB)

    Otozai, Shinji [Department of Otorhinolaryngology and Head and Neck Surgery, Osaka University School of Medicine, Osaka 565-0871 (Japan); Ishikawa-Fujiwara, Tomoko [Department of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka University, B4, 2-2 Yamadaoka, Suita, Osaka 565-0871 (Japan); Oda, Shoji [Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8562 (Japan); Kamei, Yasuhiro [Department of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka University, B4, 2-2 Yamadaoka, Suita, Osaka 565-0871 (Japan); Ryo, Haruko [Nomura Project, National Institute of Biomedical Innovation, Osaka 565-0085 (Japan); Sato, Ayuko [Department of Pathology, Hyogo College of Medicine, Hyogo 663-8501 (Japan); Nomura, Taisei [Nomura Project, National Institute of Biomedical Innovation, Osaka 565-0085 (Japan); Mitani, Hiroshi [Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8562 (Japan); Tsujimura, Tohru [Department of Pathology, Hyogo College of Medicine, Hyogo 663-8501 (Japan); Inohara, Hidenori [Department of Otorhinolaryngology and Head and Neck Surgery, Osaka University School of Medicine, Osaka 565-0871 (Japan); Todo, Takeshi, E-mail: todo@radbio.med.osaka-u.ac.jp [Department of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka University, B4, 2-2 Yamadaoka, Suita, Osaka 565-0871 (Japan)

    2014-02-15

    Highlights: • Radiation-induced microsatellite instability (MSI) was investigated in medaka fish. • msh2{sup −/−} fish had a high frequency of spontaneous MSI. • p53{sup −/−} fish had a high frequency of radiation-induced MSI. • p53 and msh2 suppress MSI by different pathways: mismatch removal and apoptosis. - Abstract: Radiation increases mutation frequencies at tandem repeat loci. Germline mutations in γ-ray-irradiated medaka fish (Oryzias latipes) were studied, focusing on the microsatellite loci. Mismatch-repair genes suppress microsatellite mutation by directly removing altered sequences at the nucleotide level, whereas the p53 gene suppresses genetic alterations by eliminating damaged cells. The contribution of these two defense mechanisms to radiation-induced microsatellite instability was addressed. The spontaneous mutation frequency was significantly higher in msh2{sup −/−} males than in wild-type fish, whereas there was no difference in the frequency of radiation-induced mutations between msh2{sup −/−} and wild-type fish. By contrast, irradiated p53{sup −/−} fish exhibited markedly increased mutation frequencies, whereas their spontaneous mutation frequency was the same as that of wild-type fish. In the spermatogonia of the testis, radiation induced a high level of apoptosis both in wild-type and msh2{sup −/−} fish, but negligible levels in p53{sup −/−} fish. The results demonstrate that the msh2 and p53 genes protect genome integrity against spontaneous and radiation-induced mutation by two different pathways: direct removal of mismatches and elimination of damaged cells.

  13. p53-Dependent suppression of genome instability in germ cells

    International Nuclear Information System (INIS)

    Otozai, Shinji; Ishikawa-Fujiwara, Tomoko; Oda, Shoji; Kamei, Yasuhiro; Ryo, Haruko; Sato, Ayuko; Nomura, Taisei; Mitani, Hiroshi; Tsujimura, Tohru; Inohara, Hidenori; Todo, Takeshi

    2014-01-01

    Highlights: • Radiation-induced microsatellite instability (MSI) was investigated in medaka fish. • msh2 −/− fish had a high frequency of spontaneous MSI. • p53 −/− fish had a high frequency of radiation-induced MSI. • p53 and msh2 suppress MSI by different pathways: mismatch removal and apoptosis. - Abstract: Radiation increases mutation frequencies at tandem repeat loci. Germline mutations in γ-ray-irradiated medaka fish (Oryzias latipes) were studied, focusing on the microsatellite loci. Mismatch-repair genes suppress microsatellite mutation by directly removing altered sequences at the nucleotide level, whereas the p53 gene suppresses genetic alterations by eliminating damaged cells. The contribution of these two defense mechanisms to radiation-induced microsatellite instability was addressed. The spontaneous mutation frequency was significantly higher in msh2 −/− males than in wild-type fish, whereas there was no difference in the frequency of radiation-induced mutations between msh2 −/− and wild-type fish. By contrast, irradiated p53 −/− fish exhibited markedly increased mutation frequencies, whereas their spontaneous mutation frequency was the same as that of wild-type fish. In the spermatogonia of the testis, radiation induced a high level of apoptosis both in wild-type and msh2 −/− fish, but negligible levels in p53 −/− fish. The results demonstrate that the msh2 and p53 genes protect genome integrity against spontaneous and radiation-induced mutation by two different pathways: direct removal of mismatches and elimination of damaged cells

  14. Chromosomal instability in the progeny of irradiated parents

    International Nuclear Information System (INIS)

    Voro btsova, I.E.; Vorobyova, M.V.; Bogomazova, A.N.

    1997-01-01

    Genomic instability have been demonstrated in irradiated cells as the increased frequency of sporadic chromosome aberrations persisted over multiple generations of cell divisions. We found that chromosomal instability characterized as well the somatic cells of irradiated parents progeny. It means that radiation induced genomic instability can be transmitted via germ line cells. As a measure of instability the sensitivity of chromosomes to radiation was estimated. In animal experiments the irradiation of mature germ cells of male rats (dose - 4.5 Gy of X-rays) increase the frequency of chromosome aberrations induced by challenging irradiation in regenerating hepatocytes, in bone marrow cells and in fetal fibroblasts in the progeny of irradiated male rats. The chromosomal sensitivity of cultivated lymphocytes to in vitro irradiation (1.5 Gy of γ(rays 137 Cs) is increased in the children born parents undergone antitumor radiotherapy or worked as 'liquidators' of Chernobyl accident consequences before conception in comparison to the children of unexposed parents. The cytogenetic radiosensitivity of lymphocytes to irradiation in vitro is also increased in children evacuated from contaminated by radionuclides areas ('positive' control group). The increased spontaneous frequency of chromatid-type acentric was found in all group of children with irradiation history. The instability of genome of irradiated parents progeny seems could be the mechanism of these health effects. (authors)

  15. Two-stream cyclotron radiative instabilities due to the marginally mirror-trapped fraction for fustion alphas in tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Arunasalam, V.

    1995-07-01

    It is shown here that the marginally mirror-trapped fraction of the newly-born fusion alpha particles in the deuterium-tritium (DT) reaction dominated tokamak plasmas can induce a two-stream cyclotron radiative instability for the fast Alfven waves propagating near the harmonics of the alpha particle cyclotron frequency {omega}{sub c{alpha}}. This can explain both the experimentally observed time behavior and the spatially localized origin of the fusion product ion cyclotron emission (ICE) in TFTR at frequencies {omega} {approx} m{omega}{sub c{alpha}}.

  16. Two-stream cyclotron radiative instabilities due to the marginally mirror-trapped fraction for fustion alphas in tokamaks

    International Nuclear Information System (INIS)

    Arunasalam, V.

    1995-07-01

    It is shown here that the marginally mirror-trapped fraction of the newly-born fusion alpha particles in the deuterium-tritium (DT) reaction dominated tokamak plasmas can induce a two-stream cyclotron radiative instability for the fast Alfven waves propagating near the harmonics of the alpha particle cyclotron frequency ω cα . This can explain both the experimentally observed time behavior and the spatially localized origin of the fusion product ion cyclotron emission (ICE) in TFTR at frequencies ω ∼ mω cα

  17. Parametric spatiotemporal oscillation in reaction-diffusion systems.

    Science.gov (United States)

    Ghosh, Shyamolina; Ray, Deb Shankar

    2016-03-01

    We consider a reaction-diffusion system in a homogeneous stable steady state. On perturbation by a time-dependent sinusoidal forcing of a suitable scaling parameter the system exhibits parametric spatiotemporal instability beyond a critical threshold frequency. We have formulated a general scheme to calculate the threshold condition for oscillation and the range of unstable spatial modes lying within a V-shaped region reminiscent of Arnold's tongue. Full numerical simulations show that depending on the specificity of nonlinearity of the models, the instability may result in time-periodic stationary patterns in the form of standing clusters or spatially localized breathing patterns with characteristic wavelengths. Our theoretical analysis of the parametric oscillation in reaction-diffusion system is corroborated by full numerical simulation of two well-known chemical dynamical models: chlorite-iodine-malonic acid and Briggs-Rauscher reactions.

  18. Manifestations and mechanisms of non-targeted effects of ionizing radiation

    International Nuclear Information System (INIS)

    Wright, Eric G.

    2010-01-01

    A well-established radiobiological paradigm is that the biological effects of ionizing radiation occur in irradiated cells as a consequence of the DNA damage they incur. However, many observations of, so-called, non-targeted effects indicate that genetic alterations are not restricted to directly irradiated cells. Non-targeted effects are responses exhibited by non-irradiated cells that are the descendants of irradiated cells (radiation-induced genomic instability) or by cells that have communicated with irradiated cells (radiation-induced bystander effects). Radiation-induced genomic instability is characterized by chromosomal abnormalities, gene mutations and cell death. Similar effects, as well as responses that may be regarded as protective, have been attributed to bystander mechanisms. The majority of studies to date have used in vitro systems but some non-targeted effects have been demonstrated in vivo and there is also evidence for radiation-induced instability in the mammalian germ line. However, there may be situations where radiation-induced genomic instability in vivo may not necessarily identify genomically unstable somatic cells but the manifestation of responses to ongoing production of damaging signals generated by genotype-dependent mechanisms having properties in common with inflammatory processes. Non-targeted mechanisms have significant implications for understanding mechanisms of radiation action but the current state of knowledge does not permit definitive statements about whether these phenomena have implications for assessing radiation risk.

  19. Persistent genetic instability induced by synergistic interaction between x-irradiation and 6-thioguanine

    International Nuclear Information System (INIS)

    Grosovsky, A.J.; Nelson, S.L.; Smith, L.E.

    1995-01-01

    Clonal karyotypic analysis was performed using G-banding on four groups of clones derived from TK6 human lymphoblasts: 25 HPRT - total gene deletion mutants induced by exposure to 2 Gy of x-rays; 8 spontaneous HPRT - total gene deletion mutants; 25 clones irradiated with 2 Gy, not selected with 6-thioguanine. Ten to twenty metaphases were examined for each clone. Extensive karyotypic heterogeneity was observed among x-ray induced HPRT - mutants involving translocations, deletions, duplications and aneuploidy; recovery of chromosomal aberrations and karyotypic heterogeneity was greater than the additive effects of clones treated with x-irradiation or 6-thioguanine alone. This synergistic interaction between x-irradiation and 6-thioguanine was observed despite a 7 day phenotypic expression interval between exposure to the two agents. Thus, x-irradiated TK6 cells appear to be persistently hypersensitive to the induction of genetic instability. Several mutants appeared to exhibit evidence of clonal evolution since aberrant chromosomes observed in one metaphase, were found to be further modified in other metaphases. In order to determine if genetic instability, identified by clonal karyotypic heterogeneity, affected specific locus mutation rates, we utilized the heterozygous thymidine kinase (tk) locus as a genetic marker. Four x-ray induced HPRT - mutants with extensive karyotypic heterogeneity, exhibited mutation rates at tk ranging from 5 to 8 fold higher than the parental TK6 cells. Further analysis, using fractionated low dose radiation exposure, is currently in progress

  20. Macromechanical Parametric Amplification

    DEFF Research Database (Denmark)

    Neumeyer, Stefan

    between the two peaks can be altered. The first experimental bistable amplified steady-state responses are also reported. The derived analytical models and experimental setups can readily be extended to investigate other factors. Some of the results are also applicable to the more general field of systems...... for energy harvesting. Using analytical, numerical, and experimental methods, the thesis focuses on superthreshold pumping (above the systems parametric instability threshold), nonlinear effects, frequency response backbones, and frequency detuning effects for parametric amplifiers. Part one of the thesis...... covers superthreshold pumping and nonlinear effects. Superthresh-old pumping produces some useful characteristics. For instance, strong superthreshold pumping yields a high gain even though nonlinear effects tend to reduce it. In addition, a narrower excitation phase range is realized for which...

  1. Jeans instability in collisional strongly coupled dusty plasma with radiative condensation and polarization force

    International Nuclear Information System (INIS)

    Prajapati, R. P.; Bhakta, S.; Chhajlani, R. K.

    2016-01-01

    The influence of dust-neutral collisions, polarization force, and electron radiative condensation is analysed on the Jeans (gravitational) instability of partially ionized strongly coupled dusty plasma (SCDP) using linear perturbation (normal mode) analysis. The Boltzmann distributed ions, dynamics of inertialess electrons, charged dust and neutral particles are considered. Using the plane wave solutions, a general dispersion relation is derived which is modified due to the presence of dust-neutral collisions, strong coupling effect, polarization force, electron radiative condensation, and Jeans dust/neutral frequencies. In the long wavelength perturbations, the Jeans instability criterion depends upon strong coupling effect, polarization interaction parameter, and thermal loss, but it is independent of dust-neutral collision frequency. The stability of the considered configuration is analysed using the Routh–Hurwitz criterion. The growth rates of Jeans instability are illustrated, and stabilizing influence of viscoelasticity and dust-neutral collision frequency while destabilizing effect of electron radiative condensation, polarization force, and Jeans dust-neutral frequency ratio is observed. This work is applied to understand the gravitational collapse of SCDP with dust-neutral collisions.

  2. Experimental and numerical investigations on flashing-induced instabilities in a single channel

    Energy Technology Data Exchange (ETDEWEB)

    Marcel, Christian P.; Rohde, M.; Van Der Hagen, T.H.J.J. [Department of Physics of Nuclear Reactors, Delft University of Technology (TUDelft), Delft, 2629 JB (Netherlands)

    2009-11-15

    During the start-up phase, natural circulation BWRs (NC-BWRs) need to be operated at low pressure conditions. Such conditions favor flashing-induced instabilities due to the large hydrostatic pressure drop induced by the tall chimney. Moreover, in novel NC-BWR designs the steam separation is performed in the steam separators which create large pressure drops at the chimney outlet, which effect on stability has not been investigated yet. In this work, flashing-induced oscillations occurring in a tall, bottom heated channel are numerically investigated by using a simple linear model with three regions and an accurate implementation for estimating the water properties. The model is used to investigate flashing-induced instabilities in a channel for different values of the core inlet friction value. The results are compared with experiments obtained by using the CIRCUS facility at the same conditions, showing a good agreement. In addition, the experiments on flashing-induced instabilities are presented in a novel manner allowing visualizing new details of the phenomenon numerical stability investigations on the effect of the friction distribution are also done. It is found that by increasing the total restriction in the channel the system is destabilized. In addition, the chimney outlet restriction has a stronger destabilizing effect than the core inlet restriction. A stable two-phase region is observed prior to the instabilities in the experiments and the numerical simulations which may help to pressurize the vessel of NC-BWRs and thus reducing the effects of flashing instabilities during start-up. (author)

  3. Parametric modulation in the Taylor-Couette ferrofluid flow

    International Nuclear Information System (INIS)

    Singh, Jitender; Bajaj, Renu

    2008-01-01

    A parametric instability of the Taylor-Couette ferrofluid flow excited by a periodically oscillating magnetic field, has been investigated numerically. The Floquet analysis has been employed. It has been found that the modulation of the applied magnetic field affects the stability of the basic flow. The instability response has been found to be synchronous with respect to the frequency of periodically oscillating magnetic field.

  4. Nonlinear parametric instability of wind turbine wings

    DEFF Research Database (Denmark)

    Larsen, Jesper Winther; Nielsen, Søren R.K.

    2006-01-01

    -base eigenmodes. It turns out that the system becomes unstable at certain excitation amplitudes and frequencies. If the ratio between the support point motion and the rotational frequency of the rotor is rational, the response becomes periodic, and Floquet theory may be used to determine instability. In reality...

  5. Electron/electron acoustic instability

    International Nuclear Information System (INIS)

    Gary, S.P.

    1987-01-01

    The electron acoustic wave becomes a normal mode of an unmagnetized collisionless plasma in the presence of two electron components with similar densities, but strongly disparate temperatures. The characteristic frequency of this mode is the plasma frequency of the cooler electron component. If these two electron components have a relative drift speed several times the thermal speed of the cooler component, the electron/electron acoustic instability may arise. This paper describes the parametric dependences of the threshold drift speed and maximum growth rate of this instability, and compares these with the same properties of the electron/ion acoustic instability. Under the condition of zero current, the electron/ion acoustic instability typically has the lower threshold drift speed, so that observation of the electron/electron acoustic instability is a strong indication of the presence of an electrical current in the plasma

  6. Suppression of the Rayleigh-Taylor instability due to self-radiation in a multiablation target

    International Nuclear Information System (INIS)

    Fujioka, Shinsuke; Sunahara, Atsushi; Nishihara, Katsunobu; Johzaki, Tomoyuki; Shiraga, Hiroyuki; Shigemori, Keisuke; Nakai, Mitsuo; Ikegawa, Tadashi; Murakami, Masakatsu; Nagai, Keiji; Norimatsu, Takayoshi; Azechi, Hiroshi; Yamanaka, Tatsuhiko; Ohnishi, Naofumi

    2004-01-01

    A scheme to suppress the Rayleigh-Taylor instability has been investigated for a direct-drive inertial fusion target. In a high-Z doped-plastic target, two ablation surfaces are formed separately--one driven by thermal radiation and the other driven by electron conduction. The growth of the Rayleigh-Taylor instability is significantly suppressed on the radiation-driven ablation surface inside the target due to the large ablation velocity and long density scale length. A significant reduction of the growth rate was observed in simulations and experiments using a brominated plastic target. A new direct-drive pellet was designed using this scheme

  7. Bystander Effect Induced by UV Radiation; why should we be interested? 

    Directory of Open Access Journals (Sweden)

    Maria Widel

    2012-11-01

    Full Text Available The bystander effect, whose essence is an interaction of cells directly subjected to radiation with adjacent non-subjected cells, via molecular signals, is an important component of ionizing radiation action. However, knowledge of the bystander effect in the case of ultraviolet (UV radiation is quite limited. Reactive oxygen and nitrogen species generated by UV in exposed cells induce bystander effects in non-exposed cells, such as reduction in clonogenic cell survival and delayed cell death, oxidative DNA damage and gene mutations, induction of micronuclei, lipid peroxidation and apoptosis. Although the bystander effect after UV radiation has been recognized in cell culture systems, its occurrence in vivo has not been studied. However, solar UV radiation, which is the main source of UV in the environment, may induce in human dermal tissue an inflammatory response and immune suppression, events which can be considered as bystander effects of UV radiation. The oxidative damage to DNA, genomic instability and the inflammatory response may lead to carcinogenesis. UV radiation is considered one of the important etiologic factors for skin cancers, basal- and squamous-cell carcinomas and malignant melanoma. Based on the mechanisms of actions it seems that the UV-induced bystander effect can have some impact on skin damage (carcinogenesis?, and probably on cells of other tissues. The paper reviews the existing data about the UV-induced bystander effect and discusses a possible implication of this phenomenon for health risk. 

  8. Parametric instabilities in large plasmas

    International Nuclear Information System (INIS)

    Brambilla, Marco; Liberman, Bernardo.

    1979-01-01

    Parametric decay processes in large plasmas are considered as the linear stage of a three wave interaction (pump, sideband and beat wave) in which the amplitude of the externally excited pump is sufficiently large to neglect pump depletion to first order, yet sufficiently small to allow a linearized treatment of the pump propagation to zeroth order. The coupling coefficients are then obtained from an iterative solution of Vlasov equation, and a compact expression is derived, in which the multiple series over Bessel functions is explicitly summed. Even in the limit of a very long wavelength pump, the dispersion relation obtained in this way does not coincide with the one obtained using the well-known ''dipole'' approximation, unless both the sideband and beat wave are resonant modes of the plasma. An analysis of the origin of this discrepancy allows us to conclude that ''quasimodes'' (evanescent waves driven absolutely unstable by the pump) are more correctly described by the iterative approach

  9. Involvement of reactive oxygen species (ROS) in the induction of genetic instability by radiation

    International Nuclear Information System (INIS)

    Tominaga, Hideyuki; Kodama, Seiji; Suzuki, Keiji; Watanabe, Masami; Matsuda, Naoki

    2004-01-01

    Radiation generates reactive oxygen species (ROS) that interact with cellular molecules, including DNA, lipids, and proteins. To know how ROS contribute to the induction of genetic instability, we examined the effect of the anti-ROS condition, using both ascorbic acid phosphate (APM) treatment or a low oxygen condition, on the induction of delayed reproductive cell death and delayed chromosome aberrations. The primary surviving colonies of mouse m5S-derived cl. 2011-14 cells irradiated with 6 Gy of X-rays were replated and allowed to form secondary colonies. The anti-ROS treatments were applied to either preirradiation culture or postirradiation cultures for primary or secondary colony formation. Both anti-ROS conditions relieved X-ray-induced acute cell killing to a similar extent. These anti-ROS conditions also relieved genetic instability when those conditions were applied during primary colony formation. However, no effect was observed when the conditions were applied during preirradiation culture and secondary colony formation. We also demonstrated that the amounts of ROS in X-ray-irradiated cells rapidly increase and then decrease at 6 hr postirradiation, and the levels of ROS then gradually decrease to a baseline within 2 weeks. The APM treatment kept the ROS production at a lower level than an untreated control. These results suggest that the cause of genetic instability might be fixed by ROS during a 2-week postirradiation period. (author)

  10. Waves and instabilities in plasmas

    International Nuclear Information System (INIS)

    Chen, L.

    1987-01-01

    The contents of this book are: Plasma as a Dielectric Medium; Nyquist Technique; Absolute and Convective Instabilities; Landau Damping and Phase Mixing; Particle Trapping and Breakdown of Linear Theory; Solution of Viasov Equation via Guilding-Center Transformation; Kinetic Theory of Magnetohydrodynamic Waves; Geometric Optics; Wave-Kinetic Equation; Cutoff and Resonance; Resonant Absorption; Mode Conversion; Gyrokinetic Equation; Drift Waves; Quasi-Linear Theory; Ponderomotive Force; Parametric Instabilities; Problem Sets for Homework, Midterm and Final Examinations

  11. Long-term biological effects induced by ionizing radiation--implications for dose mediated risk.

    Science.gov (United States)

    Miron, S D; Astărăstoae, V

    2014-01-01

    Ionizing radiations are considered to be risk agents that are responsible for the effects on interaction with living matter. The occurring biological effects are due to various factors such as: dose, type of radiation, exposure time, type of biological tissue, health condition and the age of the person exposed. The mechanisms involved in the direct modifications of nuclear DNA and mitochondrial DNA are reviewed. Classical target theory of energy deposition in the nucleus that causes DNA damages, in particular DNA double-strand breaks and that explanation of the biological consequences of ionizing radiation exposure is a paradigm in radiobiology. Recent experimental evidences have demonstrated the existence of a molecular mechanism that explains the non-targeted effects of ionizing radiation exposure. Among these novel data, genomic instability and a variety of bystander effects are discussed here. Those bystander effects of ionizing radiation are fulfilled by cellular communication systems that give rise to non-targeted effects in the neighboring non irradiated cells. This paper provides also a commentary on the synergistic effects induced by the co-exposures to ionizing radiation and various physical agents such as electromagnetic fields and the co-exposures to ionizing radiation and chemical environmental contaminants such as metals. The biological effects of multiple stressors on genomic instability and bystander effects are also discussed. Moreover, a brief presentation of the methods used to characterize cyto- and genotoxic damages is offered.

  12. GSK-3 inhibitors induce chromosome instability

    Directory of Open Access Journals (Sweden)

    Staples Oliver D

    2007-08-01

    Full Text Available Abstract Background Several mechanisms operate during mitosis to ensure accurate chromosome segregation. However, during tumour evolution these mechanisms go awry resulting in chromosome instability. While several lines of evidence suggest that mutations in adenomatous polyposis coli (APC may promote chromosome instability, at least in colon cancer, the underlying mechanisms remain unclear. Here, we turn our attention to GSK-3 – a protein kinase, which in concert with APC, targets β-catenin for proteolysis – and ask whether GSK-3 is required for accurate chromosome segregation. Results To probe the role of GSK-3 in mitosis, we inhibited GSK-3 kinase activity in cells using a panel of small molecule inhibitors, including SB-415286, AR-A014418, 1-Azakenpaullone and CHIR99021. Analysis of synchronised HeLa cells shows that GSK-3 inhibitors do not prevent G1/S progression or cell division. They do, however, significantly delay mitotic exit, largely because inhibitor-treated cells have difficulty aligning all their chromosomes. Although bipolar spindles form and the majority of chromosomes biorient, one or more chromosomes often remain mono-oriented near the spindle poles. Despite a prolonged mitotic delay, anaphase frequently initiates without the last chromosome aligning, resulting in chromosome non-disjunction. To rule out the possibility of "off-target" effects, we also used RNA interference to selectively repress GSK-3β. Cells deficient for GSK-3β exhibit a similar chromosome alignment defect, with chromosomes clustered near the spindle poles. GSK-3β repression also results in cells accumulating micronuclei, a hallmark of chromosome missegregation. Conclusion Thus, not only do our observations indicate a role for GSK-3 in accurate chromosome segregation, but they also raise the possibility that, if used as therapeutic agents, GSK-3 inhibitors may induce unwanted side effects by inducing chromosome instability.

  13. Anisotropic instability of the photoelectrons generated by soft x-ray radiation of the laser-produced plasma focus

    International Nuclear Information System (INIS)

    Klumov, B.A.; Tarakanov, V.P.

    1994-01-01

    The electron field with the anisotropic distribution function is being formed when the gas is being affected with ionizing radiation. The anisotropy of the distribution function occurs due to the fact that photoelectrons fly mainly in the direction perpendicular to that of ionizing radiation quantum propagation. In order to emphasize the most typical features of the developed anisotropic instability, photoelectrons were believed to fly strictly across the photon propagation direction. Two-dimensional electromagnetic particle simulations have been carried out to study high-frequency disturbances in the plasma produced by ionizing radiation. Elastic processes were taken into account. It has been shown, in particular, that the energy of anisotropic electrons transforms mainly into that of magnetic pulsations (approximately 7% of the energy transforms into that of magnetic pulsations). Development of the anisotropic instability result in a space stratification into current filaments. The anisotropic instability study can be important for an interpretation of electromagnetic emission spectra for a plasma disturbed by radiation

  14. Parametric excitation of nonlinear longitudinal oscillations in a magnetoactive plasma

    International Nuclear Information System (INIS)

    Demchenko, V.V.

    1977-01-01

    Parametric excitation by HF field of nonlinear longitudinal electron oscillations in the region of hybrid resonances of a cold nonrelativistic plasma has been investigated. It is shown that the inhomogeneity of a pumping field and that of the equilibrium plasma density result in the parametric instability. Expressions are derived for the increments of instable oscillations and the widths of the instability regions are determined. The increments of instable oscillations in the order of magnitude due to the inhomogeneities of the pumping field (γsub(E)) or of the plasma density (γsub(N)) are egual to γsub(E) approximately k(zetasub(0)) ωsub(pe), γsub(N) approximately (zetasub(0))/Lωsub(pe), where (zetasub(0))=(e)Esub(0)/msub(e)ωsub(0)sup(2) is the amplitude of displacement of an electron from the equilibrium state, k, ω 0 , E 0 are the wave number, frequency and amplitude of the pumping field, L is the characteristic size of the inhomogeneity of the plasma density, ωsub(pe) is the electron plasma frequency

  15. Rayleigh-Taylor and Richtmyer-Meshkov instability induced flow, turbulence, and mixing. I

    Science.gov (United States)

    Zhou, Ye

    2017-12-01

    Rayleigh-Taylor (RT) and Richtmyer-Meshkov (RM) instabilities play an important role in a wide range of engineering, geophysical, and astrophysical flows. They represent a triggering event that, in many cases, leads to large-scale turbulent mixing. Much effort has been expended over the past 140 years, beginning with the seminal work of Lord Rayleigh, to predict the evolution of the instabilities and of the instability-induced mixing layers. The objective of Part I of this review is to provide the basic properties of the flow, turbulence, and mixing induced by RT, RM, and Kelvin-Helmholtz (KH) instabilities. Historical efforts to study these instabilities are briefly reviewed, and the significance of these instabilities is discussed for a variety of flows, particularly for astrophysical flows and for the case of inertial confinement fusion. Early experimental efforts are described, and analytical attempts to model the linear, and nonlinear regimes of these mixing layers are examined. These analytical efforts include models for both single-mode and multi-mode initial conditions, as well as multi-scale models to describe the evolution. Comparisons of these models and theories to experimental and simulation studies are then presented. Next, attention is paid to the issue of the influence of stabilizing mechanisms (e.g., viscosity, surface tension, and diffuse interface) on the evolution of these instabilities, as well as the limitations and successes of numerical methods. Efforts to study these instabilities and mixing layers using group-theoretic ideas, as well as more formal notions of turbulence cascade processes during the later stages of the induced mixing layers, are inspected. A key element of the review is the discussion of the late-time self-similar scaling for the RT and RM growth factors, α and θ. These parameters are influenced by the initial conditions and much of the observed variation can be explained by this. In some cases, these instabilities

  16. Observation of parametric instabilities in the quarter critical density region driven by the Nike KrF laser

    Energy Technology Data Exchange (ETDEWEB)

    Weaver, J. L.; Kehne, D.; Brown, C. M.; Obenschain, S. P.; Serlin, V.; Schmitt, A. J. [U.S. Naval Research Laboratory, Washington DC 20375 (United States); Oh, J.; Lehmberg, R. H.; Mclean, E.; Manka, C. [Research Support Instruments, Lanham, Maryland 20905 (United States); Phillips, L. [Alogus Research Corporation, McLean, Virginia 22101 (United States); Afeyan, B. [Polymath Research, Inc., Pleasanton, California 94566 (United States); Seely, J.; Feldman, U. [Berkeley Research Associates, Inc., Beltsville, Maryland 20705 (United States)

    2013-02-15

    The krypton-fluoride (KrF) laser is an attractive choice for inertial confinement fusion due to its combination of short wavelength ({lambda}=248 nm), large bandwidth (up to 3 THz), and superior beam smoothing by induced spatial incoherence. These qualities improve the overall hydrodynamics of directly driven pellet implosions and should allow use of increased laser intensity due to higher thresholds for laser plasma instabilities when compared to frequency tripled Nd:glass lasers ({lambda}=351 nm). Here, we report the first observations of the two-plasmon decay instability using a KrF laser. The experiments utilized the Nike laser facility to irradiate solid plastic planar targets over a range of pulse lengths (0.35 ns{<=}{tau}{<=}1.25 ns) and intensities (up to 2 Multiplication-Sign 10{sup 15} W/cm{sup 2}). Variation of the laser pulse created different combinations of electron temperature and electron density scale length. The observed onset of instability growth was consistent with the expected scaling that KrF lasers have a higher intensity threshold for instabilities in the quarter critical density region.

  17. Observation of parametric instabilities in the quarter critical density region driven by the Nike KrF laser

    International Nuclear Information System (INIS)

    Weaver, J. L.; Kehne, D.; Brown, C. M.; Obenschain, S. P.; Serlin, V.; Schmitt, A. J.; Oh, J.; Lehmberg, R. H.; Mclean, E.; Manka, C.; Phillips, L.; Afeyan, B.; Seely, J.; Feldman, U.

    2013-01-01

    The krypton-fluoride (KrF) laser is an attractive choice for inertial confinement fusion due to its combination of short wavelength (λ=248 nm), large bandwidth (up to 3 THz), and superior beam smoothing by induced spatial incoherence. These qualities improve the overall hydrodynamics of directly driven pellet implosions and should allow use of increased laser intensity due to higher thresholds for laser plasma instabilities when compared to frequency tripled Nd:glass lasers (λ=351 nm). Here, we report the first observations of the two-plasmon decay instability using a KrF laser. The experiments utilized the Nike laser facility to irradiate solid plastic planar targets over a range of pulse lengths (0.35 ns≤τ≤1.25 ns) and intensities (up to 2×10 15 W/cm 2 ). Variation of the laser pulse created different combinations of electron temperature and electron density scale length. The observed onset of instability growth was consistent with the expected scaling that KrF lasers have a higher intensity threshold for instabilities in the quarter critical density region.

  18. Observation of parametric instabilities in the quarter critical density region driven by the Nike KrF laser

    Science.gov (United States)

    Weaver, J. L.; Oh, J.; Phillips, L.; Afeyan, B.; Seely, J.; Kehne, D.; Brown, C. M.; Obenschain, S. P.; Serlin, V.; Schmitt, A. J.; Feldman, U.; Lehmberg, R. H.; Mclean, E.; Manka, C.

    2013-02-01

    The krypton-fluoride (KrF) laser is an attractive choice for inertial confinement fusion due to its combination of short wavelength (λ =248 nm), large bandwidth (up to 3 THz), and superior beam smoothing by induced spatial incoherence. These qualities improve the overall hydrodynamics of directly driven pellet implosions and should allow use of increased laser intensity due to higher thresholds for laser plasma instabilities when compared to frequency tripled Nd:glass lasers (λ =351 nm). Here, we report the first observations of the two-plasmon decay instability using a KrF laser. The experiments utilized the Nike laser facility to irradiate solid plastic planar targets over a range of pulse lengths (0.35 ns≤τ≤1.25 ns) and intensities (up to 2×1015 W/cm2). Variation of the laser pulse created different combinations of electron temperature and electron density scale length. The observed onset of instability growth was consistent with the expected scaling that KrF lasers have a higher intensity threshold for instabilities in the quarter critical density region.

  19. Raman and loss induced quantum noise in depleted fiber optical parametric amplifiers

    DEFF Research Database (Denmark)

    Friis, Søren Michael Mørk; Rottwitt, Karsten; McKinstrie, C. J.

    2013-01-01

    We present a semi-classical approach for predicting the quantum noise properties of fiber optical parametric amplifiers. The unavoidable contributors of noise, vacuum fluctuations, loss-induced noise, and spontaneous Raman scattering, are included in the analysis of both phase-insensitive and phase...

  20. Experimental study of parametric instabilities and anomalous heating in plasma

    International Nuclear Information System (INIS)

    Batanov, G.M.; Rabinovich, M.S.

    1975-01-01

    Over the last few years the study of the dissipation of electromagnetic wave energy in a hot plasma has become perhaps one of the main problems of high-temperature plasma physics and controlled thermonuclear fusion. The focus of attention is on the processes by which electromagnetic energy is transformed into potential plasma waves and the processes involving relaxation of the latter. In this paper the authors summarize the experimental research into these processes conducted at the Lebedev Physics Institute over the 10 cm wave band. In the case of an isotropic plasma the authors recorded non-linear generation of Langmuir noise, the energy density of which was found to be comparable, in order of magnitude, with that of a pump wave. They detected the generation of fast-electron streams, the non-stationary character of the latter with respect to time, and non-linear transmissivity of the plasma layer. In the case of a magnetoactive plasma they studied the parametric excitation of oscillations at the upper hybrid frequency during its resonance with the first overtone of the pump wave. Excitation of plasma noise was found to be accompanied by a flux of fast-electrons, in the energy spectrum of which separate groups were detected. It was also found that the effective collision frequency increased by 1-3 orders, compared to the pari-collision frequency. In the region of magnetic waves close to the electron cyclotron resonance the authors observed forced Mandel'shtam-Brillouin scattering and kinetic instability of the plasma. It was found that the excitation of ionic Langmuir noise preceded ''anomalous absorption'' of waves and ''anomalous heating'' of electrons. The authors further consider the possibility of an experimental study of anomalous heating in plasma in the region of the lower hybrid frequencies, using the Institute's L-2 stellarator. (author)

  1. Threshold of decay instability in an inhomogeneous plasma (Leningrad 1973)

    International Nuclear Information System (INIS)

    Piliia, A.D.

    It is shown that in a spatially inhomogeneous plasma there can exist an absolute decay instability with a threshold lower than that found earlier. This instability arises when two parametrically coupled waves have turning points inside the plasma layer. The cause of the instability is a positive inverse coupling, caused by a nonlinear conversion and a reflection of the waves

  2. Radiation-induced apoptosis

    International Nuclear Information System (INIS)

    Ohyama, Harumi

    1995-01-01

    Apoptosis is an active process of gene-directed cellular self-destruction that can be induced in many cell types via numerous physiological and pathological stimuli. We found that interphasedeath of thymocytes is a typical apoptosis showing the characteristic features of apoptosis including cell shrinkage, chromatin condensation and DNA degradation. Moderate dose of radiation induces extensive apoptosis in rapidly proliferating cell population such as the epithelium of intestinal crypt. Recent reports indicate that the ultimate form of radiation-induced mitotic death in several cells is also apoptosis. One of the hallmarks of apoptosis is the enzymatic internucleosomal degradation of chromatin DNA. We identified an endonuclease responsible for the radiation-induced DNA degradation in rat thymocytes. The death-sparing effects of interrupting RNA and protein synthesis suggested a cell genetic program for apoptosis. Apoptosis of thymocytes initiated by DNA damage, such as radiation and radio mimetic substance, absolutely requires the protein of p53 cancer suppresser gene. The cell death induced by glucocorticoid, or aging, has no such requirement. Expression of oncogene bcl-2 rescues cells from the apoptosis. Massive apoptosis in radiosensitive cells induced by higher dose radiation may be fatal. It is suggested that selective apoptotic elimination of cells would play an important role for protection against carcinogenesis and malformation through removal of cells with unrepaired radiation-induced DNA damages. Data to evaluate the significance of apoptosis in the radiation risk are still poor. Further research should be done in order to clarify the roles of the cell death on the acute and late effects of irradiation. (author)

  3. On the ghost-induced instability on de Sitter background

    Science.gov (United States)

    Peter, Patrick; Salles, Filipe de O.; Shapiro, Ilya L.

    2018-03-01

    It is known that the perturbative instability of tensor excitations in higher derivative gravity may not take place if the initial frequency of the gravitational waves is below the Planck threshold. One can assume that this is a natural requirement if the cosmological background is sufficiently mild, since in this case the situation is qualitatively close to the free gravitational wave in flat space. Here, we explore the opposite situation and consider the effect of a very far from Minkowski radiation-dominated or de Sitter cosmological background with a large Hubble rate, e.g., typical of an inflationary period. It turns out that, then, for initial Planckian or even trans-Planckian frequencies, the instability is rapidly suppressed by the very fast expansion of the Universe.

  4. Contribution of bystander effects in radiation induced genotoxicity

    International Nuclear Information System (INIS)

    Zhou, H.; Persaud, R.; Gillispie, J.; Randers-Pehrson, G.; Hei, T.K.; Suzuki, Masao

    2005-01-01

    The controversial use of a linear, no threshold extrapolation model for low dose risk assessment is based on the accepted dogma that the deleterious effects of ionizing radiation such as mutagenesis and carcinogenesis are attributable mainly to direct damage to DNA. However, this extrapolation was challenged by the recent reports on the bystander phenomenon. The bystander effect contributes to this debate by implying that the biological effects of low doses, where not all cells are traversed by a charged particle, are amplified by the transfer of factors to un-irradiated neighbors. This interested phenomenon implies that a linear extrapolation of risks from high to low doses may underestimate rather than over estimate low dose risks. Together with some radiation-induced phenomena such as adaptive response and genomic instability, the radiobiological response at low doses is likely to be a complex interplay among many factors. (author)

  5. Absorption of turbulent laser plasma radiation

    International Nuclear Information System (INIS)

    Silin, V.P.

    1979-02-01

    Some theoretical results relating to the interaction of high-power laser radiation with a plasma are presented including the development of a theory of parametric instabilities in an inhomogeneous laser plasma which shows that the size of the spatial region in which the turbulent state develops is comparable with the characteristic dimension of a several-fold fluctuation in the plasma density close to its critical value. The conditions are identified under which parametric turbulence gives an anomalous effective collision frequency substantially greater than the normal electron-ion collision frequency. Even during the build-up of strong parametric turbulence, conditions are found for the development of anomalous dissipation which results in heating of the bulk of the electrons. Under opposite conditions, the dynamic behaviour due to the influence of the ponderomotive forces associated with the p component of the radiation field shows that under slow plasma flow conditions, a considerable proportion of the laser energy absorbed by the plasma is transferred to the fast electrons. Suppression of the Cherenkov mechanism for generation of the fast electron component is observed on transition to fast plasma flow conditions. (author)

  6. Modeling and simulations of radiative blast wave driven Rayleigh-Taylor instability experiments

    Science.gov (United States)

    Shimony, Assaf; Huntington, Channing M.; Trantham, Matthew; Malamud, Guy; Elbaz, Yonatan; Kuranz, Carolyn C.; Drake, R. Paul; Shvarts, Dov

    2017-10-01

    Recent experiments at the National Ignition Facility measured the growth of Rayleigh-Taylor RT instabilities driven by radiative blast waves, relevant to astrophysics and other HEDP systems. We constructed a new Buoyancy-Drag (BD) model, which accounts for the ablation effect on both bubble and spike. This ablation effect is accounted for by using the potential flow model ]Oron et al PoP 1998], adding another term to the classical BD formalism: βDuA / u , where β the Takabe constant, D the drag term, uA the ablation velocity and uthe instability growth velocity. The model results are compared with the results of experiments and 2D simulations using the CRASH code, with nominal radiation or reduced foam opacity (by a factor of 1000). The ablation constant of the model, βb / s, for the bubble and for the spike fronts, are calibrated using the results of the radiative shock experiments. This work is funded by the Lawrence Livermore National Laboratory under subcontract B614207, and was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract No. DE-AC52-07NA27344.

  7. P53 Gene Mutation as Biomarker of Radiation Induced Cell Injury and Genomic Instability

    International Nuclear Information System (INIS)

    Mukh-Syaifudin

    2006-01-01

    Gene expression profiling and its mutation has become one of the most widely used approaches to identify genes and their functions in the context of identify and categorize genes to be used as radiation effect markers including cell and tissue sensitivities. Ionizing radiation produces genetic damage and changes in gene expression that may lead to cancer due to specific protein that controlling cell proliferation altered the function, its expression or both. P53 protein encoded by p53 gene plays an important role in protecting cell by inducing growth arrest and or cell suicide (apoptosis) after deoxyribonucleic acid (DNA) damage induced by mutagen such as ionizing radiation. The mutant and thereby dysfunctional of this gene was found in more than 50% of various human cancers, but it is as yet unclear how p53 mutations lead to neoplastic development. Wild-type p53 has been postulated to play a role in DNA repair, suggesting that expression of mutant forms of p53 might alter cellular resistance to the DNA damage caused by radiation. Moreover, p53 is thought to function as a cell cycle checkpoint after irradiation, also suggesting that mutant p53 might change the cellular proliferative response to radiation. P53 mutations affect the cellular response to DNA damage, either by increasing DNA repair processes or, possibly, by increasing cellular tolerance to DNA damage. The association of p53 mutations with increased radioresistance suggests that alterations in the p53 gene might lead to oncogenic transformation. Current attractive model of carcinogenesis also showed that p53 gene is the major target of radiation. The majority of p53 mutations found so far is single base pair changes ( point mutations), which result in amino acid substitutions or truncated forms of the p53 protein, and are widely distributed throughout the evolutionary conserved regions of the gene. Examination of p53 mutations in human cancer also shows an association between particular carcinogens and

  8. Density Fluctuations in the Solar Wind Driven by Alfvén Wave Parametric Decay

    Science.gov (United States)

    Bowen, Trevor A.; Badman, Samuel; Hellinger, Petr; Bale, Stuart D.

    2018-02-01

    Measurements and simulations of inertial compressive turbulence in the solar wind are characterized by anti-correlated magnetic fluctuations parallel to the mean field and density structures. This signature has been interpreted as observational evidence for non-propagating pressure balanced structures, kinetic ion-acoustic waves, as well as the MHD slow-mode. Given the high damping rates of parallel propagating compressive fluctuations, their ubiquity in satellite observations is surprising and suggestive of a local driving process. One possible candidate for the generation of compressive fluctuations in the solar wind is the Alfvén wave parametric instability. Here, we test the parametric decay process as a source of compressive waves in the solar wind by comparing the collisionless damping rates of compressive fluctuations with growth rates of the parametric decay instability daughter waves. Our results suggest that generation of compressive waves through parametric decay is overdamped at 1 au, but that the presence of slow-mode-like density fluctuations is correlated with the parametric decay of Alfvén waves.

  9. REIONIZATION ON LARGE SCALES. I. A PARAMETRIC MODEL CONSTRUCTED FROM RADIATION-HYDRODYNAMIC SIMULATIONS

    International Nuclear Information System (INIS)

    Battaglia, N.; Trac, H.; Cen, R.; Loeb, A.

    2013-01-01

    We present a new method for modeling inhomogeneous cosmic reionization on large scales. Utilizing high-resolution radiation-hydrodynamic simulations with 2048 3 dark matter particles, 2048 3 gas cells, and 17 billion adaptive rays in a L = 100 Mpc h –1 box, we show that the density and reionization redshift fields are highly correlated on large scales (∼> 1 Mpc h –1 ). This correlation can be statistically represented by a scale-dependent linear bias. We construct a parametric function for the bias, which is then used to filter any large-scale density field to derive the corresponding spatially varying reionization redshift field. The parametric model has three free parameters that can be reduced to one free parameter when we fit the two bias parameters to simulation results. We can differentiate degenerate combinations of the bias parameters by combining results for the global ionization histories and correlation length between ionized regions. Unlike previous semi-analytic models, the evolution of the reionization redshift field in our model is directly compared cell by cell against simulations and performs well in all tests. Our model maps the high-resolution, intermediate-volume radiation-hydrodynamic simulations onto lower-resolution, larger-volume N-body simulations (∼> 2 Gpc h –1 ) in order to make mock observations and theoretical predictions

  10. Plasma wave instability and amplification of terahertz radiation in field-effect-transistor arrays

    International Nuclear Information System (INIS)

    Popov, V V; Tsymbalov, G M; Shur, M S

    2008-01-01

    We show that the strong amplification of terahertz radiation takes place in an array of field-effect transistors at small DC drain currents due to hydrodynamic plasmon instability of the collective plasmon mode. Planar designs compatible with standard integrated circuit fabrication processes and strong coupling of terahertz radiation to plasmon modes in FET arrays make such arrays very attractive for potential applications in solid-state terahertz amplifiers and emitters

  11. Detection of chromosomal instability in α-irradiated and bystander human fibroblasts

    International Nuclear Information System (INIS)

    Ponnaiya, Brian; Jenkins-Baker, Gloria; Bigelow, Alan; Marino, Stephen; Geard, Charles R.

    2004-01-01

    There is increasing evidence biological responses to ionizing radiation are not confined to those cells that are directly hit, but may be seen in the progeny at subsequent generations (genomic instability) and in non-irradiated neighbors of irradiated cells (bystander effects). These so called non-targeted phenomena would have significant contributions to radiation-induced carcinogenesis, especially at low doses where only a limited number of cells in a population are directed hit. Here we present data using a co-culturing protocol examining chromosomal instability in α-irradiated and bystander human fibroblasts BJ1-htert. At the first cell division following exposure to 0.1 and 1 Gy α-particles, irradiated populations demonstrated a dose dependent increase in chromosome-type aberrations. At this time bystander BJ1-htert populations demonstrated elevated chromatid-type aberrations when compared to controls. Irradiated and bystander populations were also analyzed for chromosomal aberrations as a function of time post-irradiation. When considered over 25 doublings, all irradiated and bystander populations had significantly higher frequencies of chromatid aberrations when compared to controls (2-3-fold over controls) and were not dependent on dose. The results presented here support the link between the radiation-induced phenomena of genomic instability and the bystander effect

  12. Radiation condensation instability of compressional electromagnetic modes in magnetoplasmas containing charged dust impurities

    International Nuclear Information System (INIS)

    Shukla, P K; Eliasson, B; Kopp, A

    2006-01-01

    We report on an investigation into the radiation condensation (RC) instability of low-frequency (in comparison with the electron gyrofrequency) compressional electromagnetic waves in a magnetized plasma containing charged dust impurities. By using a two-fluid model, supplemented by the Faraday and Ampere laws, we derive a new dispersion relation. The latter is numerically analysed to examine the role of charged dust grains on the growth rate of the RC instability. The relevance of our investigation to density condensation in the next generation tokamak edges and on solar prominences is discussed

  13. Efficient primary and parametric resonance excitation of bistable resonators

    KAUST Repository

    Ramini, Abdallah

    2016-09-12

    We experimentally demonstrate an efficient approach to excite primary and parametric (up to the 4th) resonance of Microelectromechanical system MEMS arch resonators with large vibrational amplitudes. A single crystal silicon in-plane arch microbeam is fabricated such that it can be excited axially from one of its ends by a parallel-plate electrode. Its micro/nano scale vibrations are transduced using a high speed camera. Through the parallel-plate electrode, a time varying electrostatic force is applied, which is converted into a time varying axial force that modulates dynamically the stiffness of the arch resonator. Due to the initial curvature of the structure, not only parametric excitation is induced, but also primary resonance. Experimental investigation is conducted comparing the response of the arch near primary resonance using the axial excitation to that of a classical parallel-plate actuation where the arch itself forms an electrode. The results show that the axial excitation can be more efficient and requires less power for primary resonance excitation. Moreover, unlike the classical method where the structure is vulnerable to the dynamic pull-in instability, the axial excitation technique can provide large amplitude motion while protecting the structure from pull-in. In addition to primary resonance, parametrical resonances are demonstrated at twice, one-half, and two-thirds the primary resonance frequency. The ability to actuate primary and/or parametric resonances can serve various applications, such as for resonator based logic and memory devices. (C) 2016 Author(s). All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license

  14. Decay instability of a whistler in a plasma

    International Nuclear Information System (INIS)

    Tewari, D.P.; Sharma, R.R.

    1982-01-01

    The parametric instabilities of a high power whistler in a high density plasma possess large growth rate when the scattered sideband is an electrostatic lower hybrid mode. The efficient channels of decay include oscillating two stream instability, nonlinear Landau damping and resonant decay involving ion acoustic and ion cyclotron modes. The processes of nonlinear scattering, i.e., the ones possessing whistler sidebands are relatively less significant. (author)

  15. Epstein–Barr virus particles induce centrosome amplification and chromosomal instability

    Science.gov (United States)

    Shumilov, Anatoliy; Tsai, Ming-Han; Schlosser, Yvonne T.; Kratz, Anne-Sophie; Bernhardt, Katharina; Fink, Susanne; Mizani, Tuba; Lin, Xiaochen; Jauch, Anna; Mautner, Josef; Kopp-Schneider, Annette; Feederle, Regina; Hoffmann, Ingrid; Delecluse, Henri-Jacques

    2017-01-01

    Infections with Epstein–Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection of B-lymphocytes (in vitro and in a mouse model) leads to an increased rate of centrosome amplification, associated with chromosomal instability. This effect can be reproduced with virus-like particles devoid of EBV DNA, but not with defective virus-like particles that cannot infect host cells. Viral protein BNRF1 induces centrosome amplification, and BNRF1-deficient viruses largely lose this property. These findings identify a new mechanism by which EBV particles can induce chromosomal instability without establishing a chronic infection, thereby conferring a risk for development of tumours that do not necessarily carry the viral genome. PMID:28186092

  16. Heat loads to divertor nearby components from secondary radiation evolved during plasma instabilities

    Energy Technology Data Exchange (ETDEWEB)

    Sizyuk, V., E-mail: vsizyuk@purdue.edu; Hassanein, A., E-mail: hassanein@purdue.edu [Center for Materials under Extreme Environment, School of Nuclear Engineering, Purdue University, West Lafayette, IN 47907 (United States)

    2015-01-15

    A fundamental issue in tokamak operation related to power exhaust during plasma instabilities is the understanding of heat and particle transport from the core plasma into the scrape-off layer and to plasma-facing materials. During abnormal and disruptive operation in tokamaks, radiation transport processes play a critical role in divertor/edge-generated plasma dynamics and are very important in determining overall lifetimes of the divertor and nearby components. This is equivalent to or greater than the effect of the direct impact of escaped core plasma on the divertor plate. We have developed and implemented comprehensive enhanced physical and numerical models in the upgraded HEIGHTS package for simulating detailed photon and particle transport in the evolved edge plasma during various instabilities. The paper describes details of a newly developed 3D Monte Carlo radiation transport model, including optimization methods of generated plasma opacities in the full range of expected photon spectra. Response of the ITER divertor's nearby surfaces due to radiation from the divertor-developed plasma was simulated by using actual full 3D reactor design and magnetic configurations. We analyzed in detail the radiation emission spectra and compared the emission of both carbon and tungsten as divertor plate materials. The integrated 3D simulation predicted unexpectedly high damage risk to the open stainless steel legs of the dome structure in the current ITER design from the intense radiation during a disruption on the tungsten divertor plate.

  17. Parametric analysis of protective grid flow induced vibration

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Jooyoung; Eom, Kyongbo; Jeon, Sangyoun; Suh, Jungmin [KEPCO NF Co., Daejeon (Korea, Republic of)

    2012-10-15

    Protective grid (P-grid) flow-induced vibration in a nuclear power reactor is one of the critical factors for the mechanical integrity of a nuclear fuel. The P-grid is located at the lower most position above the bottom nozzle of the nuclear fuel as shown in Fig. 1, and it is required for not only filtering debris, but also supporting fuel rods. On the other hand, P-grid working conditions installed in a nuclear fuel in a reactor are severe in terms of flow speed, temperature and pressure. Considering such a severe condition of P-grid's functional performance in working environment, excessive vibration could be developed. Furthermore, if the P-grid is exposed to high levels of excessive vibration over a long period of time, fatigue failure could be unavoidable. Therefore, it is important to reduce excessive vibration while maintaining P-grid's own functional performance. KEPCO Nuclear Fuel has developed a test facility - Investigation Flow-induced Vibration (INFINIT) - to study flow-induced vibration caused by flowing coolant at various flow rates. To investigate specific relationships between configuration of P-grid and flow-induced vibration characteristics, several types of the P-grids were tested in INFINIT facility. And, based on the test results through parametric studies, the flow-induced vibration characteristics could be analyzed, and critical design parameters were found.

  18. Pressure-anisotropy-induced nonlinearities in the kinetic magnetorotational instability

    Science.gov (United States)

    Squire, J.; Quataert, E.; Kunz, M. W.

    2017-12-01

    In collisionless and weakly collisional plasmas, such as hot accretion flows onto compact objects, the magnetorotational instability (MRI) can differ significantly from the standard (collisional) MRI. In particular, pressure anisotropy with respect to the local magnetic-field direction can both change the linear MRI dispersion relation and cause nonlinear modifications to the mode structure and growth rate, even when the field and flow perturbations are very small. This work studies these pressure-anisotropy-induced nonlinearities in the weakly nonlinear, high-ion-beta regime, before the MRI saturates into strong turbulence. Our goal is to better understand how the saturation of the MRI in a low-collisionality plasma might differ from that in the collisional regime. We focus on two key effects: (i) the direct impact of self-induced pressure-anisotropy nonlinearities on the evolution of an MRI mode, and (ii) the influence of pressure anisotropy on the `parasitic instabilities' that are suspected to cause the mode to break up into turbulence. Our main conclusions are: (i) The mirror instability regulates the pressure anisotropy in such a way that the linear MRI in a collisionless plasma is an approximate nonlinear solution once the mode amplitude becomes larger than the background field (just as in magnetohyrodynamics). This implies that differences between the collisionless and collisional MRI become unimportant at large amplitudes. (ii) The break up of large-amplitude MRI modes into turbulence via parasitic instabilities is similar in collisionless and collisional plasmas. Together, these conclusions suggest that the route to magnetorotational turbulence in a collisionless plasma may well be similar to that in a collisional plasma, as suggested by recent kinetic simulations. As a supplement to these findings, we offer guidance for the design of future kinetic simulations of magnetorotational turbulence.

  19. The instability of the spiral wave induced by the deformation of elastic excitable media

    International Nuclear Information System (INIS)

    Ma Jun; Jia Ya; Wang Chunni; Li Shirong

    2008-01-01

    There are some similarities between the spiral wave in excitable media and in cardiac tissue. Much evidence shows that the appearance and instability of the spiral wave in cardiac tissue can be linked to one kind of heart disease. There are many models that can be used to investigate the formation and instability of the spiral wave. Cardiac tissue is excitable and elastic, and it is interesting to simulate the transition and instability of the spiral wave induced by media deformation. For simplicity, a class of the modified Fitzhugh-Nagumo (MFHN) model, which can generate a stable rotating spiral wave, meandering spiral wave and turbulence within appropriate parameter regions, will be used to simulate the instability of the spiral wave induced by the periodical deformation of media. In the two-dimensional case, the total acreage of elastic media is supposed to be invariable in the presence of deformation, and the problem is described with L x x L y = N x ΔxN x Δy = L' x L' y = N x Δx'N x Δy'. In our studies, elastic media are decentralized into N x N sites and the space of the adjacent sites is changed to simulate the deformation of elastic media. Based on the nonlinear dynamics theory, the deformation effect on media is simplified and simulated by perturbing the diffusion coefficients D x and D y with different periodical signals, but the perturbed diffusion coefficients are compensatory. The snapshots of our numerical results find that the spiral wave can coexist with the spiral turbulence, instability of the spiral wave and weak deformation of the spiral wave in different conditions. The ratio parameter ε and the frequency of deformation forcing play a deterministic role in inducing instability of the spiral wave. Extensive studies confirm that the instability of the spiral wave can be induced and developed only if an appropriate frequency for deformation is used. We analyze the power spectrum for the time series of the mean activator of four sampled sites

  20. The instability of the spiral wave induced by the deformation of elastic excitable media

    Science.gov (United States)

    Ma, Jun; Jia, Ya; Wang, Chun-Ni; Li, Shi-Rong

    2008-09-01

    There are some similarities between the spiral wave in excitable media and in cardiac tissue. Much evidence shows that the appearance and instability of the spiral wave in cardiac tissue can be linked to one kind of heart disease. There are many models that can be used to investigate the formation and instability of the spiral wave. Cardiac tissue is excitable and elastic, and it is interesting to simulate the transition and instability of the spiral wave induced by media deformation. For simplicity, a class of the modified Fitzhugh-Nagumo (MFHN) model, which can generate a stable rotating spiral wave, meandering spiral wave and turbulence within appropriate parameter regions, will be used to simulate the instability of the spiral wave induced by the periodical deformation of media. In the two-dimensional case, the total acreage of elastic media is supposed to be invariable in the presence of deformation, and the problem is described with Lx × Ly = N × ΔxN × Δy = L'xL'y = N × Δx'N × Δy'. In our studies, elastic media are decentralized into N × N sites and the space of the adjacent sites is changed to simulate the deformation of elastic media. Based on the nonlinear dynamics theory, the deformation effect on media is simplified and simulated by perturbing the diffusion coefficients Dx and Dy with different periodical signals, but the perturbed diffusion coefficients are compensatory. The snapshots of our numerical results find that the spiral wave can coexist with the spiral turbulence, instability of the spiral wave and weak deformation of the spiral wave in different conditions. The ratio parameter ɛ and the frequency of deformation forcing play a deterministic role in inducing instability of the spiral wave. Extensive studies confirm that the instability of the spiral wave can be induced and developed only if an appropriate frequency for deformation is used. We analyze the power spectrum for the time series of the mean activator of four sampled sites

  1. Reversible beam heater for suppression of microbunching instability by transverse gradient undulators

    Science.gov (United States)

    Liu, Tao; Qin, Weilun; Wang, Dong; Huang, Zhirong

    2017-08-01

    The microbunching instability driven by beam collective effects in a linear accelerator of a free-electron laser (FEL) facility significantly degrades the electron beam quality and FEL performance. A conventional method to suppress this instability is to introduce an additional uncorrelated energy spread by laser-electron interaction, which has been successfully operated in the Linac Coherent Light Source and Fermi@Elettra, etc. Some other ideas are recently proposed to suppress the instability without increasing energy spread, which could benefit the seeded FEL schemes. In this paper, we propose a reversible electron beam heater using two transverse gradient undulators to suppress the microbunching instability. This scheme introduces both an energy spread increase and a transverse-to-longitudinal phase space coupling, which suppress the microbunching instabilities driven by both longitudinal space charge and coherent synchrotron radiation before and within the system. Finally the induced energy spread increase and emittance growth are reversed. Theoretical analysis and numerical simulations are presented to verify the feasibility of the scheme and indicate the capability to improve the seeded FEL radiation performance.

  2. Effect of rotation on Jeans instability of magnetized radiative quantum plasma

    Science.gov (United States)

    Joshi, H.; Pensia, R. K.

    2017-03-01

    The influence of rotation on the Jeans instability of homogeneous magnetized radiative quantum plasma is investigated. The basic equations of the problem are constructed and linearized by using the Quantum Magnetohydrodynamics (QMHD) model. The general dispersion relation is obtained by using the normal mode analysis technique, which is reduced for both the transverse and the longitudinal mode of propagations and further it is reduced for the axis of rotation parallel and perpendicular to the magnetic field. We found that the stabilizing effects of rotation are decreases for a strong magnetic field which is shown in the graphical representation. We also found that the quantum correction modified the condition of Jeans instability in both modes of propagation. The stabilizing effect of rotation is more increased in the presence of quantum correction.

  3. Estimation of low-dose radiation-responsive proteins in the absence of genomic instability in normal human fibroblast cells.

    Science.gov (United States)

    Yim, Ji-Hye; Yun, Jung Mi; Kim, Ji Young; Nam, Seon Young; Kim, Cha Soon

    2017-11-01

    Low-dose radiation has various biological effects such as adaptive responses, low-dose hypersensitivity, as well as beneficial effects. However, little is known about the particular proteins involved in these effects. Here, we sought to identify low-dose radiation-responsive phosphoproteins in normal fibroblast cells. We assessed genomic instability and proliferation of fibroblast cells after γ-irradiation by γ-H2AX foci and micronucleus formation analyses and BrdU incorporation assay, respectively. We screened fibroblast cells 8 h after low-dose (0.05 Gy) γ-irradiation using Phospho Explorer Antibody Microarray and validated two differentially expressed phosphoproteins using Western blotting. Cell proliferation proceeded normally in the absence of genomic instability after low-dose γ-irradiation. Phospho antibody microarray analysis and Western blotting revealed increased expression of two phosphoproteins, phospho-NFκB (Ser536) and phospho-P70S6K (Ser418), 8 h after low-dose radiation. Our findings suggest that low-dose radiation of normal fibroblast cells activates the expression of phospho-NFκB (Ser536) and phospho-P70S6K (Ser418) in the absence of genomic instability. Therefore, these proteins may be involved in DNA damage repair processes.

  4. Evidence for the electromagnetic decay instability driven by two plasmon decay

    International Nuclear Information System (INIS)

    Baker, K.L.; Afeyan, B.B.; Estabrook, K.G.; Drake, R.P.

    1997-01-01

    This paper examines the electromagnetic decay instability (EDI) and its role in laser-produced plasmas. The electromagnetic decay instability provides another channel through which parametric instabilities involving Langmuir waves can saturate. In the case where EDI is pumped by the Langmuir waves associated with two plasmon decay, EDI is shown to present an explanation for ω o /2 emission from laser-produced plasmas which is consistent with experimental observations

  5. SELF-DESTRUCTING SPIRAL WAVES: GLOBAL SIMULATIONS OF A SPIRAL-WAVE INSTABILITY IN ACCRETION DISKS

    International Nuclear Information System (INIS)

    Bae, Jaehan; Hartmann, Lee; Nelson, Richard P.; Richard, Samuel

    2016-01-01

    We present results from a suite of three-dimensional global hydrodynamic simulations that shows that spiral density waves propagating in circumstellar disks are unstable to the growth of a parametric instability that leads to break down of the flow into turbulence. This spiral wave instability (SWI) arises from a resonant interaction between pairs of inertial waves, or inertial-gravity waves, and the background spiral wave. The development of the instability in the linear regime involves the growth of a broad spectrum of inertial modes, with growth rates on the order of the orbital time, and results in a nonlinear saturated state in which turbulent velocity perturbations are of a similar magnitude to those induced by the spiral wave. The turbulence induces angular momentum transport and vertical mixing at a rate that depends locally on the amplitude of the spiral wave (we obtain a stress parameter α ∼ 5 × 10 −4 in our reference model). The instability is found to operate in a wide range of disk models, including those with isothermal or adiabatic equations of state, and in viscous disks where the dimensionless kinematic viscosity ν ≤ 10 −5 . This robustness suggests that the instability will have applications to a broad range of astrophysical disk-related phenomena, including those in close binary systems, planets embedded in protoplanetary disks (including Jupiter in our own solar system) and FU Orionis outburst models. Further work is required to determine the nature of the instability and to evaluate its observational consequences in physically more complete disk models than we have considered in this paper.

  6. Radionuclides in radiation-induced bystander effect; may it share in radionuclide therapy?

    Science.gov (United States)

    Widel, M

    2017-01-01

    For many years in radiobiology and radiotherapy predominated the conviction that cellular DNA is the main target for ionizing radiation, however, the view has changed in the past 20 years. Nowadays, it is assumed that not only directed (targeted) radiation effect, but also an indirect (non-targeted) effect may contribute to the result of radiation treatment. Non-targeted effect is relatively well recognized after external beam irradiation in vitro and in vivo, and comprises such phenomena like radiation-induced bystander effect (RIBE), genomic instability, adaptive response and abscopal (out of field) effect. These stress-induced and molecular signaling mediated phenomena appear in non-targeted cells as variety responses resembling that observed in directly hit cells. Bystander effects can be both detrimental and beneficial in dependence on dose, dose-rate, cell type, genetic status and experimental condition. Less is known about radionuclide-induced non-targeted effects in radionuclide therapy, although, based on characteristics of the radionuclide radiation, on experiments in vitro utilizing classical and 3-D cell cultures, and preclinical study on animals it seems obvious that exposure to radionuclide is accompanied by various bystander effects, mostly damaging, less often protective. This review summarizes existing data on radionuclide induced bystander effects comprising radionuclides emitting beta- and alpha-particles and Auger electrons used in tumor radiotherapy and diagnostics. So far, separation of the direct effect of radionuclide decay from crossfire and bystander effects in clinical targeted radionuclide therapy is impossible because of the lack of methods to assess whether, and to what extent bystander effect is involved in human organism. Considerations on this topic are also included.

  7. Photon–phonon parametric oscillation induced by quadratic coupling in an optomechanical resonator

    International Nuclear Information System (INIS)

    Zhang, Lin; Ji, Fengzhou; Zhang, Xu; Zhang, Weiping

    2017-01-01

    A direct photon–phonon parametric effect of quadratic coupling on the mean-field dynamics of an optomechanical resonator in the large-scale-movement regime is found and investigated. Under a weak pumping power, the mechanical resonator damps to a steady state with a nonlinear static response sensitively modified by the quadratic coupling. When the driving power increases beyond the static energy balance, the steady states lose their stabilities via Hopf bifurcations, and the resonator produces stable self-sustained oscillation (limit-circle behavior) of discrete energies with step-like amplitudes due to the parametric effect of quadratic coupling, which can be understood roughly by the power balance between gain and loss on the resonator. A further increase in the pumping power can induce a chaotic dynamic of the resonator via a typical routine of period-doubling bifurcation, but which can be stabilized by the parametric effect through an inversion-bifurcation process back to the limit-circle states. The bifurcation-to-inverse-bifurcation transitions are numerically verified by the maximal Lyapunov exponents of the dynamics, which indicate an efficient way of suppressing the chaotic behavior of the optomechanical resonator by quadratic coupling. Furthermore, the parametric effect of quadratic coupling on the dynamic transitions of an optomechanical resonator can be conveniently detected or traced by the output power spectrum of the cavity field. (paper)

  8. Radiation-induced epigenetic alterations after low and high LET irradiations

    International Nuclear Information System (INIS)

    Aypar, Umut; Morgan, William F.; Baulch, Janet E.

    2011-01-01

    Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the missing link in understanding radiation-induced genomic instability (RIGI). This study tests the hypothesis that irradiation induces epigenetic aberrations, which could eventually lead to RIGI, and that the epigenetic aberrations induced by low linear energy transfer (LET) irradiation are different than those induced by high LET irradiations. GM10115 cells were irradiated with low LET X-rays and high LET iron (Fe) ions and evaluated for DNA damage, cell survival and chromosomal instability. The cells were also evaluated for specific locus methylation of nuclear factor-kappa B (NFκB), tumor suppressor in lung cancer 1 (TSLC1) and cadherin 1 (CDH1) gene promoter regions, long interspersed nuclear element 1 (LINE-1) and Alu repeat element methylation, CpG and non-CpG global methylation and miRNA expression levels. Irradiated cells showed increased micronucleus induction and cell killing immediately following exposure, but were chromosomally stable at delayed times post-irradiation. At this same delayed time, alterations in repeat element and global DNA methylation and miRNA expression were observed. Analyses of DNA methylation predominantly showed hypomethylation, however hypermethylation was also observed. We demonstrate that miRNA expression levels can be altered after X-ray irradiation and that these miRNA are involved in chromatin remodeling and DNA methylation. A higher incidence of epigenetic changes was observed after exposure to X-rays than Fe ions even though Fe ions elicited more chromosomal damage and cell killing. This distinction is apparent at miRNA analyses at which only three miRNA involved in two major pathways were altered after high LET irradiations while six miRNA involved in five major pathways were altered after low LET irradiations. This study also shows that the irradiated cells acquire epigenetic changes suggesting that epigenetic aberrations may arise in the

  9. Radiation-induced epigenetic alterations after low and high LET irradiations

    Energy Technology Data Exchange (ETDEWEB)

    Aypar, Umut, E-mail: uaypa001@umaryland.edu [Department of Radiation Oncology, Radiation Oncology Research Laboratory, University of Maryland School of Medicine, Baltimore, MD 21201 (United States); Morgan, William F. [Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352 (United States); Baulch, Janet E. [Department of Radiation Oncology, Radiation Oncology Research Laboratory, University of Maryland School of Medicine, Baltimore, MD 21201 (United States)

    2011-02-10

    Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the missing link in understanding radiation-induced genomic instability (RIGI). This study tests the hypothesis that irradiation induces epigenetic aberrations, which could eventually lead to RIGI, and that the epigenetic aberrations induced by low linear energy transfer (LET) irradiation are different than those induced by high LET irradiations. GM10115 cells were irradiated with low LET X-rays and high LET iron (Fe) ions and evaluated for DNA damage, cell survival and chromosomal instability. The cells were also evaluated for specific locus methylation of nuclear factor-kappa B (NF{kappa}B), tumor suppressor in lung cancer 1 (TSLC1) and cadherin 1 (CDH1) gene promoter regions, long interspersed nuclear element 1 (LINE-1) and Alu repeat element methylation, CpG and non-CpG global methylation and miRNA expression levels. Irradiated cells showed increased micronucleus induction and cell killing immediately following exposure, but were chromosomally stable at delayed times post-irradiation. At this same delayed time, alterations in repeat element and global DNA methylation and miRNA expression were observed. Analyses of DNA methylation predominantly showed hypomethylation, however hypermethylation was also observed. We demonstrate that miRNA expression levels can be altered after X-ray irradiation and that these miRNA are involved in chromatin remodeling and DNA methylation. A higher incidence of epigenetic changes was observed after exposure to X-rays than Fe ions even though Fe ions elicited more chromosomal damage and cell killing. This distinction is apparent at miRNA analyses at which only three miRNA involved in two major pathways were altered after high LET irradiations while six miRNA involved in five major pathways were altered after low LET irradiations. This study also shows that the irradiated cells acquire epigenetic changes suggesting that epigenetic aberrations may arise

  10. Mechanisms and biological importance of photon-induced bystander responses. Do they have an impact on low-dose radiation responses

    International Nuclear Information System (INIS)

    Tomita, Masanori; Maeda, Munetoshi

    2015-01-01

    Elucidating the biological effect of low linear energy transfer (LET), low-dose and/or low-dose-rate ionizing radiation is essential in ensuring radiation safety. Over the past two decades, non-targeted effects, which are not only a direct consequence of radiation-induced initial lesions produced in cellular DNA but also of intra- and inter-cellular communications involving both targeted and non-targeted cells, have been reported and are currently defining a new paradigm in radiation biology. These effects include radiation-induced adaptive response, low-dose hypersensitivity, genomic instability, and radiation-induced bystander response (RIBR). RIBR is generally defined as a cellular response that is induced in non-irradiated cells that receive bystander signals from directly irradiated cells. RIBR could thus play an important biological role in low-dose irradiation conditions. However, this suggestion was mainly based on findings obtained using high-LET charged-particle radiations. The human population (especially the Japanese, who are exposed to lower doses of radon than the world average) is more frequently exposed to low-LET photons (X-rays or γ-rays) than to high-LET charged-particle radiation on a daily basis. There are currently a growing number of reports describing a distinguishing feature between photon-induced bystander response and high-LET RIBR. In particular, photon-induced by-stander response is strongly influenced by irradiation dose, the irradiated region of the targeted cells, and p53 status. The present review focuses on the photon-induced bystander response, and discusses its impact on the low-dose radiation effect. (author)

  11. Tidal instability in exoplanetary systems evolution

    Directory of Open Access Journals (Sweden)

    Le Gal P.

    2011-02-01

    Full Text Available A new element is proposed to play a role in the evolution of extrasolar planetary systems: the tidal (or elliptical instability. It comes from a parametric resonance and takes place in any rotating fluid whose streamlines are (even slightly elliptically deformed. Based on theoretical, experimental and numerical works, we estimate the growth rate of the instability for hot-jupiter systems, when the rotation period of the star is known. We present the physical process, its application to stars, and preliminary results obtained on a few dozen systems, summarized in the form of a stability diagram. Most of the systems are trapped in the so-called "forbidden zone", where the instability cannot grow. In some systems, the tidal instability is able to grow, at short timescales compared to the system evolution. Implications are discussed in the framework of misaligned transiting systems, as the rotational axis of the star would be unstable in systems where this elliptical instability grows.

  12. Near-self-imaging cavity for three-mode optoacoustic parametric amplifiers using silicon microresonators.

    Science.gov (United States)

    Liu, Jian; Torres, F A; Ma, Yubo; Zhao, C; Ju, L; Blair, D G; Chao, S; Roch-Jeune, I; Flaminio, R; Michel, C; Liu, K-Y

    2014-02-10

    Three-mode optoacoustic parametric amplifiers (OAPAs), in which a pair of photon modes are strongly coupled to an acoustic mode, provide a general platform for investigating self-cooling, parametric instability and very sensitive transducers. Their realization requires an optical cavity with tunable transverse modes and a high quality-factor mirror resonator. This paper presents the design of a table-top OAPA based on a near-self-imaging cavity design, using a silicon torsional microresonator. The design achieves a tuning coefficient for the optical mode spacing of 2.46  MHz/mm. This allows tuning of the mode spacing between amplification and self-cooling regimes of the OAPA device. Based on demonstrated resonator parameters (frequencies ∼400  kHz and quality-factors ∼7.5×10(5) we predict that the OAPA can achieve parametric instability with 1.6 μW of input power and mode cooling by a factor of 1.9×10(4) with 30 mW of input power.

  13. Effects of Ionizing Radiation on Cellular Structures, Induced Instability, and Carcinogenesis

    International Nuclear Information System (INIS)

    Resat, Marianne S.; Arthurs, Benjamin J.; Estes, Brian J.; Morgan, william F.

    2006-01-01

    According to the American Cancer Society, the United States can expect 1,368,030 new cases of cancer in 2004 [1]. Among the many carcinogens Americans are exposed to, ionizing radiation will contribute to this statistic. Humans live in a radiation environment. Ionizing radiation is in the air we breathe, the earth we live on, and the food we eat. Man-made radiation adds to this naturally occurring radiation level thereby increasing the chance for human exposure. For many decades the scientific community, governmental regulatory bodies, and concerned citizens have struggled to estimate health risks associated with radiation exposures, particularly at low doses. While cancer induction is the primary concern and the most important somatic effect of exposure to ionizing radiation, potential health risks do not involve neoplastic diseases exclusively but also include somatic mutations that might contribute to birth defects and ocular maladies, and heritable mutations that might impact on disease risks in future generations. Consequently it is important we understand the effect of ionizing radiation on cellular structures and the subsequent long-term health risks associated with exposure to ionizing radiation

  14. Current-induced atomic dynamics, instabilities, and Raman signals

    DEFF Research Database (Denmark)

    Lu, Jing Tao; Brandbyge, Mads; Hedegard, Per

    2012-01-01

    We derive and employ a semiclassical Langevin equation obtained from path integrals to describe the ionic dynamics of a molecular junction in the presence of electrical current. The electronic environment serves as an effective nonequilibrium bath. The bath results in random forces describing Joule...... heating, current-induced forces including the nonconservative wind force, dissipative frictional forces, and an effective Lorentz-type force due to the Berry phase of the nonequilibrium electrons. Using a generic two-level molecular model, we highlight the importance of both current-induced forces...... and Joule heating for the stability of the system. We compare the impact of the different forces, and the wide-band approximation for the electronic structure on our result. We examine the current-induced instabilities (excitation of runaway "waterwheel" modes) and investigate the signature...

  15. Detection and Repair of Ionizing Radiation-Induced DNA Double Strand Breaks: New Developments in Nonhomologous End Joining

    International Nuclear Information System (INIS)

    Wang, Chen; Lees-Miller, Susan P.

    2013-01-01

    DNA damage can occur as a result of endogenous metabolic reactions and replication stress or from exogenous sources such as radiation therapy and chemotherapy. DNA double strand breaks are the most cytotoxic form of DNA damage, and defects in their repair can result in genome instability, a hallmark of cancer. The major pathway for the repair of ionizing radiation-induced DSBs in human cells is nonhomologous end joining. Here we review recent advances on the mechanism of nonhomologous end joining, as well as new findings on its component proteins and regulation

  16. Detection and Repair of Ionizing Radiation-Induced DNA Double Strand Breaks: New Developments in Nonhomologous End Joining

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Chen [Departments of Biochemistry and Molecular Biology and Oncology, and Southern Alberta Cancer Research Institute, University of Calgary, Calgary (Canada); Lees-Miller, Susan P., E-mail: leesmill@ucalgary.ca [Departments of Biochemistry and Molecular Biology and Oncology, and Southern Alberta Cancer Research Institute, University of Calgary, Calgary (Canada)

    2013-07-01

    DNA damage can occur as a result of endogenous metabolic reactions and replication stress or from exogenous sources such as radiation therapy and chemotherapy. DNA double strand breaks are the most cytotoxic form of DNA damage, and defects in their repair can result in genome instability, a hallmark of cancer. The major pathway for the repair of ionizing radiation-induced DSBs in human cells is nonhomologous end joining. Here we review recent advances on the mechanism of nonhomologous end joining, as well as new findings on its component proteins and regulation.

  17. Computational parametric study of a Richtmyer-Meshkov instability for an inclined interface.

    Science.gov (United States)

    McFarland, Jacob A; Greenough, Jeffrey A; Ranjan, Devesh

    2011-08-01

    A computational study of the Richtmyer-Meshkov instability for an inclined interface is presented. The study covers experiments to be performed in the Texas A&M University inclined shock tube facility. Incident shock wave Mach numbers from 1.2 to 2.5, inclination angles from 30° to 60°, and gas pair Atwood numbers of ∼0.67 and ∼0.95 are used in this parametric study containing 15 unique combinations of these parameters. Qualitative results are examined through a time series of density plots for multiple combinations of these parameters, and the qualitative effects of each of the parameters are discussed. Pressure, density, and vorticity fields are presented in animations available online to supplement the discussion of the qualitative results. These density plots show the evolution of two main regions in the flow field: a mixing region containing driver and test gas that is dominated by large vortical structures, and a more homogeneous region of unmixed fluid which can separate away from the mixing region in some cases. The interface mixing width is determined for various combinations of the parameters listed at the beginning of the Abstract. A scaling method for the mixing width is proposed using the interface geometry and wave velocities calculated using one-dimensional gas dynamic equations. This model uses the transmitted wave velocity for the characteristic velocity and an initial offset time based on the travel time of strong reflected waves. It is compared to an adapted Richtmyer impulsive model scaling and shown to scale the initial mixing width growth rate more effectively for fixed Atwood number.

  18. Delay-induced wave instabilities in single-species reaction-diffusion systems

    Science.gov (United States)

    Otto, Andereas; Wang, Jian; Radons, Günter

    2017-11-01

    The Turing (wave) instability is only possible in reaction-diffusion systems with more than one (two) components. Motivated by the fact that a time delay increases the dimension of a system, we investigate the presence of diffusion-driven instabilities in single-species reaction-diffusion systems with delay. The stability of arbitrary one-component systems with a single discrete delay, with distributed delay, or with a variable delay is systematically analyzed. We show that a wave instability can appear from an equilibrium of single-species reaction-diffusion systems with fluctuating or distributed delay, which is not possible in similar systems with constant discrete delay or without delay. More precisely, we show by basic analytic arguments and by numerical simulations that fast asymmetric delay fluctuations or asymmetrically distributed delays can lead to wave instabilities in these systems. Examples, for the resulting traveling waves are shown for a Fisher-KPP equation with distributed delay in the reaction term. In addition, we have studied diffusion-induced instabilities from homogeneous periodic orbits in the same systems with variable delay, where the homogeneous periodic orbits are attracting resonant periodic solutions of the system without diffusion, i.e., periodic orbits of the Hutchinson equation with time-varying delay. If diffusion is introduced, standing waves can emerge whose temporal period is equal to the period of the variable delay.

  19. Induction of genetic instability in ρ53 in primary cultures of normal human urothelium exposed low-dose of gamma radiation

    International Nuclear Information System (INIS)

    Colucci, S.; Mothersill, C.; Seymour, C.; Harney, J.; Gamble, S.; Arrand, J.

    1997-01-01

    We have previously shown that primary explant cultures of human urothelium exposed to low doses of gamma radiation subsequently exhibit a high level of stable P53 but it was not clear from those studies whether this protein stabilisation occurred through epigenetic events or as a result of mutation. In these experiments, primary urothelium cultures from five different patients were exposed to 0.5 and 5 Gy γ- radiation from a 60 Cobalt source and allowed to grow for 7- 10 division cycles to allow development of any radiation-induced, non lethal changes in the urothelial cells. C-myc, Bcl-2, and stable P53 protein expression was found to be elevated in cultures following both radiation doses. Following 0.5 Gy exposure, the cultures also developed multiple distinct 'foci' of rapidly-dividing cells which strongly over-expressed P53. These grew on a background of morphologically normal cells. When such foci were selectively analysed for their p53 mutation status by PCR-SSCPE, there was evidence that they contained cells which had developed changes to thr p53 gene post-irradiation. These changes appeared to occur more frequently in focal cells than in cells of normal morphological appearance in the same culture. DNA sequence analysis of the p53 gene in 0.5 Gy-induced foci displayed frame shift mutations in some cases. These results may have mechanistic importance given the controversy regarding low-dose radiation effects and p53-related genomic instability. (authors)

  20. Graphical analysis of electron inertia induced acoustic instability

    International Nuclear Information System (INIS)

    Karmakar, P.K.; Deka, U.; Dwivedi, C.B.

    2005-01-01

    Recently, the practical significance of the asymptotic limit of m e /m i →0 for electron density distribution has been judged in a two-component plasma system with drifting ions. It is reported that in the presence of drifting ions with drift speed exceeding the ion acoustic wave speed, the electron inertial delay effect facilitates the resonance coupling of the usual fluid ion acoustic mode with the ion-beam mode. In this contribution the same instability is analyzed by graphical and numerical methods. This is to note that the obtained dispersion relation differs from those of the other known normal modes of low frequency ion plasma oscillations and waves. This is due to consideration of electron inertial delay in derivation of the dispersion relation of the ion acoustic wave fluctuations. Numerical calculations of the dispersion relation and wave energy are carried out to depict the graphical appearance of poles and positive-negative energy modes. It is found that the electron inertia induced ion acoustic wave instability arises out of linear resonance coupling between the negative and positive energy modes. Characterization of the resonance nature of the instability in Mach number space for different wave numbers of the ion acoustic mode is presented

  1. Spiral intensity patterns in the internally pumped optical parametric oscillator

    DEFF Research Database (Denmark)

    Lodahl, Peter; Bache, Morten; Saffman, Mark

    2001-01-01

    We describe a nonlinear optical system that supports spiral pattern solutions in the field intensity. This new spatial structure is found to bifurcate above a secondary instability in the internally pumped optical parametric oscillator. The analytical predictions of threshold and spatial scale...

  2. A novel approach to study effects of asymmetric stiffness on parametric instabilities of multi-rotor-system

    Science.gov (United States)

    Jain, Anuj Kumar; Rastogi, Vikas; Agrawal, Atul Kumar

    2018-01-01

    The main focus of this paper is to study effects of asymmetric stiffness on parametric instabilities of multi-rotor-system through extended Lagrangian formalism, where symmetries are broken in terms of the rotor stiffness. The complete insight of dynamic behaviour of multi-rotor-system with asymmetries is evaluated through extension of Lagrangian equation with a case study. In this work, a dynamic mathematical model of a multi-rotor-system through a novel approach of extension of Lagrangian mechanics is developed, where the system is having asymmetries due to varying stiffness. The amplitude and the natural frequency of the rotor are obtained analytically through the proposed methodology. The bond graph modeling technique is used for modeling the asymmetric rotor. Symbol-shakti® software is used for the simulation of the model. The effects of the stiffness of multi-rotor-system on amplitude and frequencies are studied using numerical simulation. Simulation results show a considerable agreement with the theoretical results obtained through extended Lagrangian formalism. It is further shown that amplitude of the rotor increases inversely the stiffness of the rotor up to a certain limit, which is also affirmed theoretically.

  3. Nitric oxide coordinates development of genomic instability in realization of combined effect with ionizing radiation.

    Science.gov (United States)

    Mikhailenko, V M; Diomina, E A; Muzalov, I I; Gerashchenko, B I

    2013-03-01

    The aim of this study was to investigate the ability of environmental nitrogen oxides or natural nitric oxide (NO) donors to modify free radicals ba-lance and development of genomic instability alone or in combination with ionizing radiation. Genotoxicity and cytogenetic abnormalities were assessed in vitro in peripheral blood lymphocytes (PBL) isolated from healthy humans or in vivo in rats PBL. Human PBL were treated with physiologically relevant NO donor - S-Nitrosoglutathione and X-ray irradiation. The inhalation treatment of animals with NO was carried out in chamber with purified gaseous NO mixed inside with air. Levels of S-Nitrosohemoglobin and methemoglobin in the blood were assessed with electron paramagnetic resonance. The total level of reactive oxygen and nitrogen species in PBL was determined fluorometrically, and serum levels of reactive oxygen species was determined by spectrophotometric assay. DNA damages were assessed by alkaline single-cell gel electrophoresis. The frequency of chromosomal aberrations in human PBL measured with the conventional cytogenetic assay in metaphase cells on short-term (52 h) and long-term (72 h) cultures. Environmental nitrogen oxides or release of NO from stable complexes with biomolecules (such as S-Nitrosothiols) intensified generation of free radicals, DNA damage and development of genomic instability alone or in combination with ionizing radiation. Treatment of PBL by S-Nitrosoglutathione caused prevalent induction of chromatid type but irradiation - chromosome aberrations. The dose dependence of chromatid-type aberrations observed in human PBL after combined influence of S-Nitrosoglutathione and ionizing radiation indicates a crucial role of NO in the formation of chromosomal instability. NO can deregulate free radicals balance resulted in genotoxic effect, posttranslational modification of repair enzymes and thus coordinated development of genomic instability and increase of cancer risk.

  4. Relativistic, Viscous, Radiation Hydrodynamic Simulations of Geometrically Thin Disks. I. Thermal and Other Instabilities

    Science.gov (United States)

    Fragile, P. Chris; Etheridge, Sarina M.; Anninos, Peter; Mishra, Bhupendra; Kluźniak, Włodek

    2018-04-01

    We present results from two-dimensional, general relativistic, viscous, radiation hydrodynamic numerical simulations of Shakura–Sunyaev thin disks accreting onto stellar-mass Schwarzschild black holes. We consider cases on both the gas- and radiation-pressure-dominated branches of the thermal equilibrium curve, with mass accretion rates spanning the range from \\dot{M}=0.01{L}Edd}/{c}2 to 10L Edd/c 2. The simulations directly test the stability of this standard disk model on the different branches. We find clear evidence of thermal instability for all radiation-pressure-dominated disks, resulting universally in the vertical collapse of the disks, which in some cases then settle onto the stable, gas-pressure-dominated branch. Although these results are consistent with decades-old theoretical predictions, they appear to be in conflict with available observational data from black hole X-ray binaries. We also find evidence for a radiation-pressure-driven instability that breaks the unstable disks up into alternating rings of high and low surface density on a timescale comparable to the thermal collapse. Since radiation is included self-consistently in the simulations, we are able to calculate light curves and power density spectra (PDS). For the most part, we measure radiative efficiencies (ratio of luminosity to mass accretion rate) close to 6%, as expected for a nonrotating black hole. The PDS appear as broken power laws, with a break typically around 100 Hz. There is no evidence of significant excess power at any frequencies, i.e., no quasi-periodic oscillations are observed.

  5. Activation barrier scaling and crossover for noise-induced switching in micromechanical parametric oscillators.

    Science.gov (United States)

    Chan, H B; Stambaugh, C

    2007-08-10

    We explore fluctuation-induced switching in parametrically driven micromechanical torsional oscillators. The oscillators possess one, two, or three stable attractors depending on the modulation frequency. Noise induces transitions between the coexisting attractors. Near the bifurcation points, the activation barriers are found to have a power law dependence on frequency detuning with critical exponents that are in agreement with predicted universal scaling relationships. At large detuning, we observe a crossover to a different power law dependence with an exponent that is device specific.

  6. Nonlinear parametric phenomena in plasma during radio frequency heating in the ion cyclotron frequency range

    International Nuclear Information System (INIS)

    Stepanov, K.N.

    1996-01-01

    Parametric phenomena in plasma which occur due to varying electric fields with the ion cyclotron frequency are reviewed. Beam-like lower hybrid instability emerges in strong pumping fields provided that the transverse relative velocity of particles is larger than the ion thermal speed (υ Ti ). The resulting turbulence and the following numerous manifestations observed experimentally are addressed. The turbulence may prove important for experiments aimed at plasma production or radio frequency (RF) cleaning of metallic surfaces of vacuum chambers in stellarators, tokamaks and helicon devices. In contrast, for a weak field (U Ti ) the kinetic parametric instabilities of ion cyclotron oscillations arise due to electrons. The issues of the turbulence, mathematical modelling, its role in turbulent heating observed on the torsatron Uragan-3M, decay instabilities associated with ion cyclotron oscillations and the triggering of ion quasimodes are considered. (author)

  7. A model of parametric X-ray radiation for application to diagnostic radiology

    International Nuclear Information System (INIS)

    Di Domenico, G.; Cardarelli, P.; Gambaccini, M.; Marziani, M.; Taibi, A.; Comandini, A.

    2011-01-01

    Parametric X-ray Radiation (PXR) is well known as an intense, tunable and quasi-monochromatic X-ray source. From the very first work of Ter-Mikaelian, who proposed the interaction phenomenon for Parametric X-rays many theoretical and experimental studies have investigated the characteristics of such a novel X-ray source. Within the framework of classical electrodynamics, we have thoroughly studied the physical implications of electrons moving through a medium at relativistic speed and then developed an analytical model of X-ray diffraction based on the PXR phenomenon. The model has been used to obtain information on the characteristics of PXR diffracted beam in terms of X-ray intensity, energy spectrum and angular distribution. Several crystals have been studied both in Bragg and Laue geometry and their relative yield has been compared. Preliminary results on the diagnostic potential of PXR have shown that, at a distance from the crystal which produces a size of the X-ray field useful for an imaging application, the photon yield of PXR is higher than that produced by a conventional X-ray tube, provided that a similar electron current is available.

  8. Epigenetics in radiation biology: a new research frontier

    International Nuclear Information System (INIS)

    Agarwal, Sural

    2014-01-01

    The number of people that receive exposure to ionizing radiation (IR) via occupational, diagnostic, or treatment-related modalities is progressively rising. It is now accepted that the negative consequences of radiation exposure are not isolated to exposed cells or individuals. Exposure to IR can induce genome instability in the germ line, and is further associated with transgenerational genomic instability in the off spring of exposed males. The exact molecular mechanisms for transgenerational genome instability have yet to be elucidated, although there is support for it being an epigenetically induced phenomenon. This review is centered on the long-term biological effects associated with IR exposure, mainly focusing on the epigentic mechanisms and also some facts about whether dental radiology (IOPA, OPG, CT, MRI, CBCT) can lead to carcinogenesis. (author)

  9. A parametric investigation on the cyclotron maser instability driven by ring-beam electrons with intrinsic Alfvén waves

    Science.gov (United States)

    Tong, Zi-Jin; Wang, Chuan-Bing; Zhang, Pei-Jin; Liu, Jin

    2017-05-01

    The electron-cyclotron maser is a process that generates the intense and coherent radio emission in the plasma. In this paper, we present a comprehensive parametric investigation on the electron-cyclotron-maser instability driven by non-thermal ring-beam electrons with intrinsic Alfvén waves, which pervade the solar atmosphere and interplanetary space. It is found that both forward propagating and backward propagating waves can be excited in the fast ordinary (O) and extraordinary (X) electromagnetic modes. The growth rates of X1 mode are almost always weakened by Alfvén waves. The average pitch-angle ϕ 0 of electrons is a key parameter for the effect of Alfvén waves on the growth rate of modes O1, O2, and X2. For a beam-dominated electron distribution ( ϕ 0 ≲ 30 ° ), the growth rates of the maser instability for O1, O2, and X2 modes are enhanced with the increase of the Alfvén wave energy density. In other conditions, the growth rates of O1, O2, and X2 modes weakened with the increasing Alfvén wave intensity, except that the growth of the O1 mode may also be enhanced by Alfvén waves for a ring distribution. The results may be important for us in analyzing the mechanism of radio bursts with various fine structures observed in space and astrophysical plasmas.

  10. Radiation-induced thermoacoustic imaging

    International Nuclear Information System (INIS)

    Bowen, T.

    1984-01-01

    This invention provides a new technique for obtaining information non-invasively on the composition and structures of a material or body by detecting radiation-induced thermoacoustic image features. This is accomplished by utilizing the acoustic wave generated by sudden thermal stress. The sudden thermal stress is induced by a pulse of radiation which deposits energy causing a rapid, but very small, rise of temperature (typically, ΔT approximately 10sup(-6) - 10sup(-5) deg C). The radiation may be ionizing radiation, such as high energy electrons, photons (x-rays), neutrons, or other charged particles or it may be non-ionizing radiation, such as R.F. and microwave electromagnetic radiation and ultrasonic radiation. The choice of radiation depends on the nature of the body to be imaged and the type of information desired

  11. Buneman instability and Pierce instability in a collisionless bounded plasma

    International Nuclear Information System (INIS)

    Iizuka, Satoru; Saeki, Koichi; Sato, Noriyoshi; Hatta, Yoshisuke

    1983-01-01

    A systematic experiment is performed on the Buneman instability and the Pierce instability in a bounded plasma consisting of beam electrons and stationary ions. Current fluctuations are confirmed to be induced by the Buneman instability. On the other hand, the Pierce instability gives rise to a current limitation. The phenomena are well explained by Mikhailovskii's theory taking account of ion motion in a bounded plasma. (author)

  12. SELF-DESTRUCTING SPIRAL WAVES: GLOBAL SIMULATIONS OF A SPIRAL-WAVE INSTABILITY IN ACCRETION DISKS

    Energy Technology Data Exchange (ETDEWEB)

    Bae, Jaehan; Hartmann, Lee [Department of Astronomy, University of Michigan, 1085 S. University Ave., Ann Arbor, MI 48109 (United States); Nelson, Richard P.; Richard, Samuel, E-mail: jaehbae@umich.edu, E-mail: lhartm@umich.edu, E-mail: r.p.nelson@qmul.ac.uk, E-mail: samuel.richard@qmul.ac.uk [Astronomy Unit, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom)

    2016-09-20

    We present results from a suite of three-dimensional global hydrodynamic simulations that shows that spiral density waves propagating in circumstellar disks are unstable to the growth of a parametric instability that leads to break down of the flow into turbulence. This spiral wave instability (SWI) arises from a resonant interaction between pairs of inertial waves, or inertial-gravity waves, and the background spiral wave. The development of the instability in the linear regime involves the growth of a broad spectrum of inertial modes, with growth rates on the order of the orbital time, and results in a nonlinear saturated state in which turbulent velocity perturbations are of a similar magnitude to those induced by the spiral wave. The turbulence induces angular momentum transport and vertical mixing at a rate that depends locally on the amplitude of the spiral wave (we obtain a stress parameter α ∼ 5 × 10{sup −4} in our reference model). The instability is found to operate in a wide range of disk models, including those with isothermal or adiabatic equations of state, and in viscous disks where the dimensionless kinematic viscosity ν ≤ 10{sup −5}. This robustness suggests that the instability will have applications to a broad range of astrophysical disk-related phenomena, including those in close binary systems, planets embedded in protoplanetary disks (including Jupiter in our own solar system) and FU Orionis outburst models. Further work is required to determine the nature of the instability and to evaluate its observational consequences in physically more complete disk models than we have considered in this paper.

  13. [Radiation-induced bystander effect: the important part of ionizing radiation response. Potential clinical implications].

    Science.gov (United States)

    Wideł, Maria; Przybyszewski, Waldemar; Rzeszowska-Wolny, Joanna

    2009-08-18

    It has long been a central radiobiological dogma that the damaging effects of ionizing radiation, such as cell death, cytogenetic changes, apoptosis, mutagenesis, and carcinogenesis, are the results of the direct ionization of cell structures, particularly DNA, or indirect damage via water radiolysis products. However, several years ago attention turned to a third mechanism of radiation, termed the "bystander effect" or "radiation-induced bystander effect" (RIBE). This is induced by agents and signals emitted by directly irradiated cells and manifests as a lowering of survival, cytogenetic damage, apoptosis enhancement, and biochemical changes in neighboring non-irradiated cells. The bystander effect is mainly observed in in vitro experiments using very low doses of alpha particles (range; mGy, cGy), but also after conventional irradiation (X-rays, gamma rays) at low as well as conventional doses. The mechanisms responsible for the bystander effect are complex and still poorly understood. It is believed that molecular signals released from irradiated cells induce different signaling ways in non-irradiated neighboring cells, leading to the observed events. The molecular signals may be transmitted through gap junction intercellular communication and through a medium transfer mechanism. The nature of these transmitted factors are diverse, and still not definitely established. It seems that RIBE may have important clinical implications for health risk associated with radiation exposure. Potentially, this effect may have important implications in the creation of whole-body or localized side effects in tissues beyond the irradiation field and also in low-dose radiological and radioisotope diagnostics. Factors emitted by irradiated cells may result in the risk of genetic instability, mutations, and second primary cancer induction. They might also have their own part in inducing and extending post-radiation side effects in normal tissue. The bystander effect may be a

  14. Radiation-induced bystander effect: The important part of ionizing radiation response. Potential clinical implications

    Directory of Open Access Journals (Sweden)

    Maria Wideł

    2009-08-01

    Full Text Available It has long been a central radiobiological dogma that the damaging effects of ionizing radiation, such as cell death, cytogenetic changes, apoptosis, mutagenesis, and carcinogenesis, are the results of the direct ionization of cell structures, particularly DNA, or indirect damage via water radiolysis products. However, several years ago attention turned to a third mechanism of radiation, termed the “bystander effect” or “radiation-induced bystander effect” (RIBE. This is induced by agents and signals emitted by directly irradiated cells and manifests as a lowering of survival, cytogenetic damage, apoptosis enhancement, and biochemical changes in neighboring non-irradiated cells. The bystander effect is mainly observed in in vitro experiments using very low doses of alpha particles (range; mGy, cGy, but also after conventional irradiation (X-rays, gamma rays at low as well as conventional doses. The mechanisms responsible for the bystander effect are complex and still poorly understood. It is believed that molecular signals released from irradiated cells induce different signaling ways in non-irradiated neighboring cells, leading to the observed events. The molecular signals may be transmitted through gap junction intercellular communication and through a medium transfer mechanism. The nature of these transmitted factors are diverse, and still not defi nitely established. It seems that RIBE may have important clinical implications for health risk associated with radiation exposure. Potentially, this effectmay have important implications in the creation of whole-body or localized side effects in tissues beyond the irradiation fi eld and also in low-dose radiological and radioisotope diagnostics. Factors emitted by irradiated cells may result in the risk of genetic instability, mutations, and second primary cancer induction. They might also have their own part in inducing and extending post-radiation side effects in normal tissue. The

  15. Three-dimensional instability analysis of boundary layers perturbed by streamwise vortices

    Science.gov (United States)

    Martín, Juan A.; Paredes, Pedro

    2017-12-01

    A parametric study is presented for the incompressible, zero-pressure-gradient flat-plate boundary layer perturbed by streamwise vortices. The vortices are placed near the leading edge and model the vortices induced by miniature vortex generators (MVGs), which consist in a spanwise-periodic array of small winglet pairs. The introduction of MVGs has been experimentally proved to be a successful passive flow control strategy for delaying laminar-turbulent transition caused by Tollmien-Schlichting (TS) waves. The counter-rotating vortex pairs induce non-modal, transient growth that leads to a streaky boundary layer flow. The initial intensity of the vortices and their wall-normal distances to the plate wall are varied with the aim of finding the most effective location for streak generation and the effect on the instability characteristics of the perturbed flow. The study includes the solution of the three-dimensional, stationary, streaky boundary layer flows by using the boundary region equations, and the three-dimensional instability analysis of the resulting basic flows by using the plane-marching parabolized stability equations. Depending on the initial circulation and positioning of the vortices, planar TS waves are stabilized by the presence of the streaks, resulting in a reduction in the region of instability and shrink of the neutral stability curve. For a fixed maximum streak amplitude below the threshold for secondary instability (SI), the most effective wall-normal distance for the formation of the streaks is found to also offer the most stabilization of TS waves. By setting a maximum streak amplitude above the threshold for SI, sinuous shear layer modes become unstable, as well as another instability mode that is amplified in a narrow region near the vortex inlet position.

  16. The Parametric Decay Instability of Alfvén Waves in Turbulent Plasmas and the Applications in the Solar Wind

    Energy Technology Data Exchange (ETDEWEB)

    Shi, Mijie; Xiao, Chijie; Wang, Xiaogang [State Key Laboratory of Nuclear Physics and Technology, Fusion Simulation Center, School of Physics, Peking University, Beijing 100871 (China); Li, Hui, E-mail: cjxiao@pku.edu.cn [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    2017-06-10

    We perform three-dimensional ideal magnetohydrodynamic (MHD) simulations to study the parametric decay instability (PDI) of Alfvén waves in turbulent plasmas and explore its possible applications in the solar wind. We find that, over a broad range of parameters in background turbulence amplitudes, the PDI of an Alfvén wave with various amplitudes can still occur, though its growth rate in turbulent plasmas tends to be lower than both the theoretical linear theory prediction and that in the non-turbulent situations. Spatial–temporal FFT analyses of density fluctuations produced by the PDI match well with the dispersion relation of the slow MHD waves. This result may provide an explanation of the generation mechanism of slow waves in the solar wind observed at 1 au. It further highlights the need to explore the effects of density variations in modifying the turbulence properties as well as in heating the solar wind plasmas.

  17. Survivin and chromosome instability induced by X-irradiation

    International Nuclear Information System (INIS)

    Shen Bo; Ju Guizhi; Liu Yang

    2006-01-01

    Objective: To explore the biological effect of survivin on chromosome instability induced by X-ray irradiation. Methods: Immunocytochemistry was used to detect the expression of sutvivin in HeLa cells. Carrier pSUPER-SVV was transfected into HeLa cells to interfere the expression of survivin. Flow cytometry assay was applied to detect the occurrence of polyploid at 0 h, 4 h, 12 h, and 48 h after the HeLa cells transfected with pSUPER-SVV and irradiated with 4 Gy X-rays irradiation, and compared with the group irradiated with 4 Gy X-rays but no transfection. Results: The expression of survivin was down-regulated by transfecting with small hair RNA, its depression rate was estimated to be about 32.16% at 48 h after transfection. The occurrence of polyploid giant cells was higher in the 4 Gy X-ray irradiated group at 48 h after the irradiation than the control groups (P<0.001). Being expression of survivin interfered, the occurrence at 12 h or 48 h after irradiation, however, was about two times higher than that in the control group. Conclusion: X-ray irradiation can induce chromosome instability in HeLa cells and the effect could be enhanced by interfering the expression of surviving. It was suggested that survivin plays an important role in maintaining the stability of chromosome. (authors)

  18. Parametric excitation electromagnetic radiation in a bounded non-equilibrium plasma

    International Nuclear Information System (INIS)

    Balakirev, V.A.; Tolstoluzhskij, A.P.

    1981-01-01

    An excitation mechanism of electromagnetic radiation in a bounded plasma-beam system which is based on the process of induced scattering of electron beam-strengthened high-frequency wave (HF) of a plasma waveguide with an ion-sound wave, is investigated. It is shown that the process under investigation is an effective mechanism of electromagnetic radiation production. Up to 73 % of the beam power is trabsformed to the electromagnetic radiation under the conditions considered. As the frequency of the irradiated wave is close to the plasma frequency it can vary within wide limits by the change in plasma density. It is noted that the necessary condition of electromagnetic radiation production in the mechanism under consideration has the form of inequality ωsub(l)-ωsub(s)/(ksub(l)-ksub(s)>c (ωsub(l) - frequency of HF wave, ωsub(s)- frequency of ion-sound wave) and is less rigid as compared with the synchronism conditions for three-wave resonant interaction of proper oscillations. Therefore, the considered induced scattering process is less sensitive to a possible inhomogeneity of plasma density [ru

  19. The effect of spin induced magnetization on Jeans instability of viscous and resistive quantum plasma

    International Nuclear Information System (INIS)

    Sharma, Prerana; Chhajlani, R. K.

    2014-01-01

    The effect of spin induced magnetization and electrical resistivity incorporating the viscosity of the medium is examined on the Jeans instability of quantum magnetoplasma. Formulation of the system is done by using the quantum magnetohydrodynamic model. The analysis of the problem is carried out by normal mode analysis theory. The general dispersion relation is derived from set of perturbed equations to analyse the growth rate and condition of self-gravitational Jeans instability. To discuss the influence of resistivity, magnetization, and viscosity parameters on Jeans instability, the general dispersion relation is reduced for both transverse and longitudinal mode of propagations. In the case of transverse propagation, the gravitating mode is found to be affected by the viscosity, magnetization, resistivity, and magnetic field strength whereas Jeans criterion of instability is modified by the magnetization and quantum parameter. In the longitudinal mode of propagation, the gravitating mode is found to be modified due to the viscosity and quantum correction in which the Jeans condition of instability is influenced only by quantum parameter. The other non-gravitating Alfven mode in this direction is affected by finite electrical resistivity, spin induced magnetization, and viscosity. The numerical study for the growth rate of Jeans instability is carried out for both in the transverse and longitudinal direction of propagation to the magnetic field. The effect of various parameters on the growth rate of Jeans instability in quantum plasma is analysed

  20. Multi-level approach for parametric roll analysis

    Science.gov (United States)

    Kim, Taeyoung; Kim, Yonghwan

    2011-03-01

    The present study considers multi-level approach for the analysis of parametric roll phenomena. Three kinds of computation method, GM variation, impulse response function (IRF), and Rankine panel method, are applied for the multi-level approach. IRF and Rankine panel method are based on the weakly nonlinear formulation which includes nonlinear Froude- Krylov and restoring forces. In the computation result of parametric roll occurrence test in regular waves, IRF and Rankine panel method show similar tendency. Although the GM variation approach predicts the occurrence of parametric roll at twice roll natural frequency, its frequency criteria shows a little difference. Nonlinear roll motion in bichromatic wave is also considered in this study. To prove the unstable roll motion in bichromatic waves, theoretical and numerical approaches are applied. The occurrence of parametric roll is theoretically examined by introducing the quasi-periodic Mathieu equation. Instability criteria are well predicted from stability analysis in theoretical approach. From the Fourier analysis, it has been verified that difference-frequency effects create the unstable roll motion. The occurrence of unstable roll motion in bichromatic wave is also observed in the experiment.

  1. Damaging and protective cell signalling in the untargeted effects of ionizing radiation

    International Nuclear Information System (INIS)

    Coates, Philip J.; Lorimore, Sally A.; Wright, Eric G.

    2004-01-01

    The major adverse consequences of radiation exposures are attributed to DNA damage in irradiated cells that has not been correctly restored by metabolic repair processes. However, the dogma that genetic alterations are restricted to directly irradiated cells has been challenged by observations in which effects of ionizing radiation arise in non-irradiated cells. These, so called, untargeted effects are demonstrated in cells that are the descendants of irradiated cells either directly or via media transfer (radiation-induced genomic instability) or in cells that have communicated with irradiated cells (radiation-induced bystander effects). Radiation-induced genomic instability is characterized by a number of delayed responses including chromosomal abnormalities, gene mutations and cell death. Bystander effects include increases or decreases in damage-inducible and stress-related proteins, increases or decreases in reactive oxygen and nitrogen species, cell death or cell proliferation, cell differentiation, radioadaptation, induction of mutations and chromosome aberrations and chromosomal instability. The phenotypic expression of untargeted effects and the potential consequences of these effects in tissues reflect a balance between the type of bystander signals produced and the responses of cell populations to such signals, both of which may be significantly influenced by cell type and genotype. Thus, in addition to targeted effects of damage induced directly in cells by irradiation, a variety of untargeted effects may also make important short-term and long-term contributions to determining overall outcome after radiation exposures

  2. Maternal effects of the scid mutation on radiation-induced transgenerational instability in mice.

    NARCIS (Netherlands)

    Hatch, T.; Derijck, A.H.A.; Black, P.D.; Heijden, G.W. van der; Boer, P. de; Dubrova, Y.E.

    2007-01-01

    The results of a number of recent studies show that mutation rates in the offspring of irradiated parents are substantially elevated, however, the effect of parental genotype on transgenerational instability remains poorly understood. Here, we have analysed the mutation frequency at an expanded

  3. Using the longitudinal space charge instability for generation of vacuum ultraviolet and x-ray radiation

    Directory of Open Access Journals (Sweden)

    E. A. Schneidmiller

    2010-11-01

    Full Text Available Longitudinal space charge (LSC driven microbunching instability in electron beam formation systems of x-ray free-electron lasers (FELs is a recently discovered effect hampering beam instrumentation and FEL operation. The instability was observed in different facilities in infrared and visible wavelength ranges. In this paper we propose to use such an instability for generation of vacuum ultraviolet (VUV and x-ray radiation. A typical longitudinal space charge amplifier (LSCA consists of few amplification cascades (drift space plus chicane with a short undulator behind the last cascade. If the amplifier starts up from the shot noise, the amplified density modulation has a wide band, on the order of unity. The bandwidth of the radiation within the central cone is given by an inverse number of undulator periods. A wavelength compression could be an attractive option for LSCA since the process is broadband, and a high compression stability is not required. LSCA can be used as a cheap addition to the existing or planned short-wavelength FELs. In particular, it can produce the second color for a pump-probe experiment. It is also possible to generate attosecond pulses in the VUV and x-ray regimes. Some user experiments can profit from a relatively large bandwidth of the radiation, and this is easy to obtain in the LSCA scheme. Finally, since the amplification mechanism is broadband and robust, LSCA can be an interesting alternative to the self-amplified spontaneous emission free-electron laser (SASE FEL in the case of using laser-plasma accelerators as drivers of light sources.

  4. Radiation-induced centers in inorganic glasses

    International Nuclear Information System (INIS)

    Brekhovskikh, S.M.; Tyul'nin, V.A.

    1988-01-01

    The nature, structure and formation mechanisms of radiation-induced colour centers, EPR, luminescence, generated ionizing radiation in nonorganic oxide glasses are considered. Experimental material covering both fundamental aspects of radiation physics and glass chemistry, and aspects intimately connected with the creation of new materials with the given radiation-spectral characteristics, with possibilities to prepare radiation-stable and radiation-sensitive glasses is systematized and generalized. Considerable attention is paid to the detection of radiation-induced center binding with composition, glass structures redox conditions for their synthesis. Some new possibilities of practical application of glasses with radiation-induced centers, in particular, to record optical information are reflected in the paper

  5. Surfactants and the Rayleigh-Taylor instability of Couette type flows

    Science.gov (United States)

    Frenkel, A. L.; Halpern, D.; Schweiger, A. S.

    2011-11-01

    We study the Rayleigh-Taylor instability of slow Couette- type flows in the presence of insoluble surfactants. It is known that with zero gravity, the surfactant makes the flow unstable to longwave disturbances in certain regions of the parameter space; while in other parametric regions, it reinforces the flow stability (Frenkel and Halpern 2002). Here, we show that in the latter parametric sectors, and when the (gravity) Bond number Bo is below a certain threshold value, the Rayleigh-Taylor instability is completely stabilized for a finite interval of Ma, the (surfactant) Marangoni number: MaL Ma2. For Ma Ma2, and also for MaL Ma2 as functions of the Bond number. We note that (for an interval of the Bond number) there are two distinct criticalities with nonzero (and distinct) critical wavenumbers.

  6. Polariton condensation, superradiance and difference combination parametric resonance in mode-locked laser

    Science.gov (United States)

    Bagayev, S. N.; Arkhipov, R. M.; Arkhipov, M. V.; Egorov, V. S.; Chekhonin, I. A.; Chekhonin, M. A.

    2017-11-01

    The generation of the ring mode-locked laser containing resonant absorption medium in the cavity was investigated. It is shown that near the strong resonant absorption lines a condensation of polaritons arises. Intensive radiation looks like as superradiance in a medium without population inversion. We studied theoretically the microscopic mechanism of these phenomena. It was shown that in this system in absorbing medium a strong self-induced difference combination parametric resonance exists. Superradiance on polaritonic modes in the absorbing medium are due to the emergence of light-induced resonant polarization as a result of fast periodic nonadiabatic quantum jumps in the absorber.

  7. Coherent Synchrotron Radiation effect in damping rings

    International Nuclear Information System (INIS)

    Raubenheimer, T

    2004-01-01

    Coherent Synchrotron Radiation (CSR) can play an important role by not only increasing the energy spread and emittance of a beam, but also leading to a potential instability. Previous studies of the CSR induced longitudinal instability were carried out for the CSR impedance due to dipole magnets. In this paper, the instability due to the CSR impedance from a wiggler is studied assuming a large wiggler parameter K. The primary consideration is a low frequency microwave-like instability in the damping rings of several linear collider projects. The threshold is determined by the instability with the longest possible wavelength

  8. Parametric excitation of electron Bernstein waves by radio waves in the ionosphere and its possible consequence for airglow

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Ashok; Tripathi, V K [Department of Physics, Indian Institute of Technology Delhi, New Delhi-110016 (India)

    2007-06-07

    A high power radio wave, launched into the polar ionosphere at angle {theta} with the earth's magnetic field from a ground-based transmitter in the vicinity of twice the electron cyclotron frequency (2.75 MHz), is reported to create an airglow at an effective radiated power (ERP) = 10 MW. We interpret this result as a consequence of parametric decay of the radio wave into an electron Bernstein wave (EBW) and an ion acoustic wave (IAW). The oscillatory velocity of electrons due to the pump couples with the density perturbation due to the IAW to produce a current, driving the Bernstein mode. The latter, in connection with the pump, exerts a ponderomotive force on electrons, driving the IAW. The growth rate of the parametric instability is maximum for {theta} = 0. At the same time, for any given value of {theta}, the growth rate increases with b(=k{sub 1}{sup 2}v{sub th}{sup 2}/2{omega}{sub c}{sup 2}) and attains a maximum around b {approx} 2, then falls gradually. The EBW produces energetic electrons via cyclotron damping. These electrons collide with the neutral atoms of the plasma to excite them to higher energy states. As the excited atoms return to lower energy states, they radiate in the visible.

  9. Parametric excitation of electron Bernstein waves by radio waves in the ionosphere and its possible consequence for airglow

    International Nuclear Information System (INIS)

    Kumar, Ashok; Tripathi, V K

    2007-01-01

    A high power radio wave, launched into the polar ionosphere at angle θ with the earth's magnetic field from a ground-based transmitter in the vicinity of twice the electron cyclotron frequency (2.75 MHz), is reported to create an airglow at an effective radiated power (ERP) = 10 MW. We interpret this result as a consequence of parametric decay of the radio wave into an electron Bernstein wave (EBW) and an ion acoustic wave (IAW). The oscillatory velocity of electrons due to the pump couples with the density perturbation due to the IAW to produce a current, driving the Bernstein mode. The latter, in connection with the pump, exerts a ponderomotive force on electrons, driving the IAW. The growth rate of the parametric instability is maximum for θ = 0. At the same time, for any given value of θ, the growth rate increases with b(=k 1 2 v th 2 /2ω c 2 ) and attains a maximum around b ∼ 2, then falls gradually. The EBW produces energetic electrons via cyclotron damping. These electrons collide with the neutral atoms of the plasma to excite them to higher energy states. As the excited atoms return to lower energy states, they radiate in the visible

  10. Parametric decay of lower hybrid wave into drift waves

    International Nuclear Information System (INIS)

    Sanuki, Heiji.

    1976-12-01

    A dispersion relation describing the parametric decay of a lower hybrid wave into an electrostatic drift wave and a drift Alfven wave is derived for an inhomogeneous magnetized plasma. Particularly the stimulated scattering of a drift Alfven wave in such a plasma was investigated in detail. The resonance backscattering instability is found to yield the minimum threshold. (auth.)

  11. Genomic instability induced by 137Cs γ-ray irradiation in CHL surviving cells

    International Nuclear Information System (INIS)

    Yue Jingyin; Liu Bingchen; Wu Hongying; Zhou Jiwen; Mu Chuanjie

    1999-01-01

    Objective: To study in parallel several possible manifestations of instability of surviving CHL cells after irradiation, namely the frequencies of mutation at locus, micronuclei and apoptosis. Methods: The frequencies of mutation at HGPRT locus, micronuclei and apoptosis were assayed at various times in surviving cells irradiated with γ-rays. Results: The surviving cells showed a persistently increased frequency of mutation at the HGPRT locus after irradiation until 53 days. Mutant fraction as high as 10 -4 was scored, tens of times higher than those assayed in control cells studied in parallel. The frequency of bi nucleated cells with micronuclei determined within 24 hours after irradiation increased with dose and reached a peak value of (26.58 +- 2.48)% at 3 Gy, decreasing at higher doses to a plateau around 20%. The micronucleus frequency decreased steeply to about (14.47 +- 2.39)% within the first 3 days post-irradiation, and fluctuated at around 10% up to 56 days post-irradiation. The delayed efficiency of irradiated cells was significantly decreased. The frequency of apoptosis peaked about (24.90 +- 4.72)% at 10 Gy 48 h post-irradiation (γ-ray dose between 3-10 Gy) and then decreased to about 12% within 3 days. It was significantly higher than in control cells until 14 days. Conclusions: It shows that genomic instability induced by radiation can be transmitted to the progeny of surviving cells and may take many forms of expression such as lethal mutation, chromosome aberrations, gene mutation, etc

  12. Radiation-induced camptocormia and dropped head syndrome. Review and case report of radiation-induced movement disorders

    International Nuclear Information System (INIS)

    Seidel, Clemens; Kuhnt, Thomas; Kortmann, Rolf-Dieter; Hering, Kathrin

    2015-01-01

    In recent years, camptocormia and dropped head syndrome (DHS) have gained attention as particular forms of movement disorders. Camptocormia presents with involuntary forward flexion of the thoracolumbar spine that typically increases during walking or standing and may severely impede walking ability. DHS is characterized by weakness of the neck extensors and a consecutive inability to extend the neck; in severe cases the head is fixed in a ''chin to chest position.'' Many diseases may underlie these conditions, and there have been some reports about radiation-induced camptocormia and DHS. A PubMed search with the keywords ''camptocormia,'' ''dropped head syndrome,'' ''radiation-induced myopathy,'' ''radiation-induced neuropathy,'' and ''radiation-induced movement disorder'' was carried out to better characterize radiation-induced movement disorders and the radiation techniques involved. In addition, the case of a patient developing camptocormia 23 years after radiation therapy of a non-Hodgkin's lymphoma of the abdomen is described. In total, nine case series of radiation-induced DHS (n = 45 patients) and - including our case - three case reports (n = 3 patients) about radiogenic camptocormia were retrieved. Most cases (40/45 patients) occurred less than 15 years after radiotherapy involving extended fields for Hodgkin's disease. The use of wide radiation fields including many spinal segments with paraspinal muscles may lead to radiation-induced movement disorders. If paraspinal muscles and the thoracolumbar spine are involved, the clinical presentation can be that of camptocormia. DHS may result if there is involvement of the cervical spine. To prevent these disorders, sparing of the spine and paraspinal muscles is desirable. (orig.) [de

  13. Contribution of radiation-induced, nitric oxide-mediated bystander effect to radiation-induced adaptive response.

    Science.gov (United States)

    Matsumoto, H.; Ohnishi, T.

    There has been a recent upsurge of interest in radiation-induced adaptive response and bystander effect which are specific modes in stress response to low-dose low-dose rate radiation Recently we found that the accumulation of inducible nitric oxide NO synthase iNOS in wt p53 cells was induced by chronic irradiation with gamma rays followed by acute irradiation with X-rays but not by each one resulting in an increase in nitrite concentrations of medium It is suggested that the accumulation of iNOS may be due to the depression of acute irradiation-induced p53 functions by pre-chronic irradiation In addition we found that the radiosensitivity of wt p53 cells against acute irradiation with X-rays was reduced after chronic irradiation with gamma rays This reduction of radiosensitivity of wt p53 cells was nearly completely suppressed by the addition of NO scavenger carboxy-PTIO to the medium This reduction of radiosensitivity of wt p53 cells is just radiation-induced adaptive response suggesting that NO-mediated bystander effect may considerably contribute to adaptive response induced by radiation

  14. Entanglement in a parametric converter

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Su-Yong; Qamar, Shahid; Lee, Hai-Woong; Zubairy, M Suhail [Center for Quantum Physics, COMSATS Institute of Information Technology, Islamabad (Pakistan)], E-mail: shahid_qamar@pieas.edu.pk, E-mail: zubairy@physics.tamu.edu

    2008-07-28

    In this paper, we consider a parametric converter as a source of entangled radiation. We examine recently derived conditions (Hillery and Zubairy 2006 Phys. Rev. Lett. 96 050503, Duan et al 2000 Phys. Rev. Lett. 84 2722) for determining when the two output modes in a parametric converter are entangled. We show that for different initial field states, the two criteria give different conditions that ensure that the output states are entangled. We also present an input-output calculation for the entanglement of the output field.

  15. Joint instability and osteoarthritis.

    Science.gov (United States)

    Blalock, Darryl; Miller, Andrew; Tilley, Michael; Wang, Jinxi

    2015-01-01

    Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated with osteoarthritis (OA). Thus, understanding the physiology of joint stability and the mechanisms of joint instability-induced OA is of clinical significance. The first section of this review discusses the structure and function of major joint tissues, including periarticular muscles, which play a significant role in joint stability. Because the knee, ankle, and shoulder joints demonstrate a high incidence of ligament injury and joint instability, the second section summarizes the mechanisms of ligament injury-associated joint instability of these joints. The final section highlights the recent advances in the understanding of the mechanical and biological mechanisms of joint instability-induced OA. These advances may lead to new opportunities for clinical intervention in the prevention and early treatment of OA.

  16. Radiation hydrodynamical instabilities in cosmological and galactic ionization fronts

    Science.gov (United States)

    Whalen, Daniel J.; Norman, Michael L.

    2011-11-01

    Ionization fronts, the sharp radiation fronts behind which H/He ionizing photons from massive stars and galaxies propagate through space, were ubiquitous in the universe from its earliest times. The cosmic dark ages ended with the formation of the first primeval stars and galaxies a few hundred Myr after the Big Bang. Numerical simulations suggest that stars in this era were very massive, 25-500 solar masses, with H(II) regions of up to 30,000 light-years in diameter. We present three-dimensional radiation hydrodynamical calculations that reveal that the I-fronts of the first stars and galaxies were prone to violent instabilities, enhancing the escape of UV photons into the early intergalactic medium (IGM) and forming clumpy media in which supernovae later exploded. The enrichment of such clumps with metals by the first supernovae may have led to the prompt formation of a second generation of low-mass stars, profoundly transforming the nature of the first protogalaxies. Cosmological radiation hydrodynamics is unique because ionizing photons coupled strongly to both gas flows and primordial chemistry at early epochs, introducing a hierarchy of disparate characteristic timescales whose relative magnitudes can vary greatly throughout a given calculation. We describe the adaptive multistep integration scheme we have developed for the self-consistent transport of both cosmological and galactic ionization fronts.

  17. Stable radiation pressure acceleration of ions by suppressing transverse Rayleigh-Taylor instability with multiple Gaussian pulses

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, M. L.; Liu, B.; Hu, R. H.; Shou, Y. R.; Lin, C.; Lu, H. Y.; Lu, Y. R.; Ma, W. J., E-mail: wenjun.ma@pku.edu.cn [State Key Laboratory of Nuclear Physics and Technology, and Key Laboratory of HEDP of the Ministry of Education, CAPT, Peking University, Beijing 100871 (China); Gu, Y. Q. [Laser Fusion Research Center, China Academy of Engineering Physics, Mianyang, Sichuan 621900 (China); Yan, X. Q., E-mail: x.yan@pku.edu.cn [State Key Laboratory of Nuclear Physics and Technology, and Key Laboratory of HEDP of the Ministry of Education, CAPT, Peking University, Beijing 100871 (China); Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan, Shanxi 030006 (China)

    2016-08-15

    In the case of a thin plasma slab accelerated by the radiation pressure of an ultra-intense laser pulse, the development of Rayleigh-Taylor instability (RTI) will destroy the acceleration structure and terminate the acceleration process much sooner than theoretical limit. In this paper, a new scheme using multiple Gaussian pulses for ion acceleration in a radiation pressure acceleration regime is investigated with particle-in-cell simulation. We found that with multiple Gaussian pulses, the instability could be efficiently suppressed and the divergence of the ion bunch is greatly reduced, resulting in a longer acceleration time and much more collimated ion bunch with higher energy than using a single Gaussian pulse. An analytical model is developed to describe the suppression of RTI at the laser-plasma interface. The model shows that the suppression of RTI is due to the introduction of the long wavelength mode RTI by the multiple Gaussian pulses.

  18. Chaotic neoclassical separatrix dissipation in parametric drift-wave decay.

    Science.gov (United States)

    Kabantsev, A A; Tsidulko, Yu A; Driscoll, C F

    2014-02-07

    Experiments and theory characterize a parametric decay instability between plasma drift waves when the nonlinear coupling is modified by an electrostatic barrier. Novel mode coupling terms representing enhanced dissipation and mode phase shifts are caused by chaotic separatrix crossings on the wave-ruffled separatrix. Experimental determination of these coupling terms is in broad agreement with new chaotic neoclassical transport analyses.

  19. Strain-induced shear instability in Liverpool Bay

    Science.gov (United States)

    Wihsgott, Juliane; Palmer, Matthew R.

    2013-04-01

    Liverpool Bay is a shallow subsection of the eastern Irish Sea with large tides (10 m), which drive strong tidal currents (1 ms-1). The Bay is heavily influenced by large freshwater inputs from several Welsh and English rivers that maintain a strong and persistent horizontal density gradient. This gradient interacts with the sheared tidal currents to strain freshwater over denser pelagic water on a semi-diurnal frequency. This Strain-Induced-Periodic-Stratification (SIPS) has important implications on vertical and horizontal mixing. The subtle interaction between stratification and turbulence in this complex environment is shown to be of critical importance to freshwater transport, and subsequently the fate of associated biogeochemical and pollutant pathways. Recent work identified an asymmetry of current ellipses due to SIPS that increases shear instability in the halocline with the potential to enhance diapycnal mixing. Here, we use data from a short, high intensity process study which reveals this mid-water mechanism maintains prolonged periods of sub-critical gradient Richardson number (Ri ≤ ¼) that suggests shear instability is likely. A time series of measurements from a microstructure profiler identifies the associated increase in turbulence is short lived and 'patchy' but sufficient to promote diapycnal mixing. The significance of this mixing process is further investigated by comparing our findings with long-term observations from the Liverpool Bay Coastal Observatory. We identify that the conditions for shear instability during SIPS are regularly met and suggest that this process contributes to the current underestimates of near coastal mixing observed in regional models. To assist our understanding of the observed processes and to test the current capability of turbulence 'closure schemes' we employ a one-dimensional numerical model to investigate the physical mechanisms driving diapycnal mixing in Liverpool Bay.

  20. Phase instability in crystals under irradiation

    International Nuclear Information System (INIS)

    Martin, G.

    1975-01-01

    A diffusion term is introduced in the standard chemical rate model of the defect population in crystals under irradiation. For point defect generation rates larger than a critical value (g*), the uniform point defect population is shown to be unstable with respect to spatial fluctuations of the point defect concentration. g* is temperature dependent. Severala effects including the nucleation of arrays of point defect clusters, or radiation induced precipitation may occur above the instability threshold. Defect-defect interaction potentials play a crucial role in the numerical value of this threshold [fr

  1. Parametric amplification and bidirectional invisibility in PT -symmetric time-Floquet systems

    Science.gov (United States)

    Koutserimpas, Theodoros T.; Alù, Andrea; Fleury, Romain

    2018-01-01

    Parity-time (PT )-symmetric wave devices, which exploit balanced interactions between material gain and loss, exhibit extraordinary properties, including lasing and flux-conserving scattering processes. In a seemingly different research field, periodically driven systems, also known as time-Floquet systems, have been widely studied as a relevant platform for reconfigurable active wave control and manipulation. In this article, we explore the connection between PT -symmetry and parametric time-Floquet systems. Instead of relying on material gain, we use parametric amplification by considering a time-periodic modulation of the refractive index at a frequency equal to twice the incident signal frequency. We show that the scattering from a simple parametric slab, whose dynamics follows the Mathieu equation, can be described by a PT -symmetric scattering matrix, whose PT -breaking threshold corresponds to the Mathieu instability threshold. By combining different parametric slabs modulated out of phase, we create PT -symmetric time-Floquet systems that feature exceptional scattering properties, such as coherent perfect absorption (CPA)-laser operation and bidirectional invisibility. These bidirectional properties, rare for regular PT -symmetric systems, are related to a compensation of parametric amplification due to multiple scattering between two parametric systems modulated with a phase difference.

  2. Corona-induced electrohydrodynamic instabilities in low conducting liquids

    Energy Technology Data Exchange (ETDEWEB)

    Vega, F.; Perez, A.T. [Depto. Electronica y Electromagnetismo, Facultad de Fisica, Universidad de Sevilla, Avda. Reina Mercedes, s/n. 41012, Sevilla (Spain)

    2003-06-01

    The rose-window electrohydrodynamic (EHD) instability has been observed when a perpendicular field with an additional unipolar ion injection is applied onto a low conducting liquid surface. This instability has a characteristic pattern with cells five to 10 times greater than those observed in volume instabilities caused by unipolar injection. We have used corona discharge from a metallic point to perform some measurements of the rose-window instability in low conducting liquids. The results are compared to the linear theoretical criterion for an ohmic liquid. They confirmed that the minimum voltage for this instability is much lower than that for the interfacial instability in high conducting liquids. This was predicted theoretically in the dependence of the critical voltage as a function of the non-dimensional conductivity. It is shown that in a non-ohmic liquid the rose window appears as a secondary instability after the volume instability. (orig.)

  3. Collapse instability of solitons in the nonpolynomial Schroedinger equation with dipole-dipole interactions

    International Nuclear Information System (INIS)

    Gligoric, G; Hadzievski, Lj; Maluckov, A; Malomed, B A

    2009-01-01

    A model of the Bose-Einstein condensate (BEC) of dipolar atoms, confined in a combination of a cigar-shaped trap and optical lattice acting in the axial direction, is studied in the framework of the one-dimensional (1D) nonpolynomial Schroedinger equation (NPSE) with additional terms describing long-range dipole-dipole (DD) interactions. The NPSE makes it possible to describe the collapse of localized modes, which was experimentally observed in the self-attractive BEC confined in tight traps, in the framework of the 1D description. We study the influence of the DD interactions on the dynamics of bright solitons, especially concerning their collapse-induced instability. Both attractive and repulsive contact and DD interactions are considered. The results are summarized in the form of stability/collapse diagrams in a respective parametric space. In particular, it is shown that the attractive DD interactions may prevent the collapse instability in the condensate with attractive contact interactions.

  4. Beam splitter coupled CdSe optical parametric oscillator

    International Nuclear Information System (INIS)

    Levinos, N.J.; Arnold, G.P.

    1980-01-01

    An optical parametric oscillator is disclosed in which the resonant radiation is separated from the pump and output radiation so that it can be manipulated without interfering with them. Thus, for example, very narrow band output may readily be achieved by passing the resonant radiation through a line narrowing device which does not in itself interfere with either the pump radiation or the output radiation

  5. Faraday instability and Faraday patterns in a superfluid Fermi gas

    International Nuclear Information System (INIS)

    Tang Rongan; Xue Jukui; Li Haocai

    2011-01-01

    With the consideration of the coupling between the transverse width and the longitudinal density, the parametric excitations related to Faraday waves in a cigar-shaped superfluid Fermi gas are studied. A Mathieu equation is obtained, and it is demonstrated firstly that the excited actual 3D Faraday pattern is the combination of the longitudinal Faraday density wave and the corresponding transverse width fluctuation in the longitudinal direction. The Faraday instability growth index and the kinematic equations of the Faraday density wave and the width fluctuation along the Bose-Einstein condensate (BEC)-Bardeen-Cooper-Schrieffer (BCS) crossover are also given for the first time. It is found that the 3D Faraday pattern presents quite different behaviours (such as the excitations and the motions) when the system crosses from the BEC side to the BCS side. The coupling not only plays an important role in the parametric excitation, but also determines the dominant wavelength of the spatial structure. Along the crossover, the coupling effects are more significant in the BCS side. The final numerical investigation verifies these results and gives a detailed study of the parametric excitations (i.e. Faraday instability) and the 3D pattern formation.

  6. An instability due to the nonlinear coupling of p-modes to g-modes: Implications for coalescing neutron star binaries

    International Nuclear Information System (INIS)

    Weinberg, Nevin N.; Arras, Phil; Burkart, Joshua

    2013-01-01

    A weakly nonlinear fluid wave propagating within a star can be unstable to three-wave interactions. The resonant parametric instability is a well-known form of three-wave interaction in which a primary wave of frequency ω a excites a pair of secondary waves of frequency ω b + ω c ≅ ω a . Here we consider a nonresonant form of three-wave interaction in which a low-frequency primary wave excites a high-frequency p-mode and a low-frequency g-mode such that ω b + ω c >> ω a . We show that a p-mode can couple so strongly to a g-mode of similar radial wavelength that this type of nonresonant interaction is unstable even if the primary wave amplitude is small. As an application, we analyze the stability of the tide in coalescing neutron star binaries to p-g mode coupling. We find that the equilibrium tide and dynamical tide are both p-g unstable at gravitational wave frequencies f gw ≳ 20 Hz and drive short wavelength p-g mode pairs to significant energies on very short timescales (much less than the orbital decay time due to gravitational radiation). Resonant parametric coupling to the tide is, by contrast, either stable or drives modes at a much smaller rate. We do not solve for the saturation of the p-g instability and therefore we cannot say precisely how it influences the evolution of neutron star binaries. However, we show that if even a single daughter mode saturates near its wave breaking amplitude, the p-g instability of the equilibrium tide will (1) induce significant orbital phase errors (Δφ ≳ 1 radian) that accumulate primarily at low frequencies (f gw ≲ 50 Hz) and (2) heat the neutron star core to a temperature of T ∼ 10 10 K. Since there are at least ∼100 unstable p-g daughter pairs, Δφ and T are potentially much larger than these values. Tides might therefore significantly influence the gravitational wave signal and electromagnetic emission from coalescing neutron star binaries at much larger orbital separations than previously

  7. Self-induced parametric amplification arising from nonlinear elastic coupling in a micromechanical resonating disk gyroscope.

    Science.gov (United States)

    Nitzan, Sarah H; Zega, Valentina; Li, Mo; Ahn, Chae H; Corigliano, Alberto; Kenny, Thomas W; Horsley, David A

    2015-03-12

    Parametric amplification, resulting from intentionally varying a parameter in a resonator at twice its resonant frequency, has been successfully employed to increase the sensitivity of many micro- and nano-scale sensors. Here, we introduce the concept of self-induced parametric amplification, which arises naturally from nonlinear elastic coupling between the degenerate vibration modes in a micromechanical disk-resonator, and is not externally applied. The device functions as a gyroscope wherein angular rotation is detected from Coriolis coupling of elastic vibration energy from a driven vibration mode into a second degenerate sensing mode. While nonlinear elasticity in silicon resonators is extremely weak, in this high quality-factor device, ppm-level nonlinear elastic effects result in an order-of-magnitude increase in the observed sensitivity to Coriolis force relative to linear theory. Perfect degeneracy of the primary and secondary vibration modes is achieved through electrostatic frequency tuning, which also enables the phase and frequency of the parametric coupling to be varied, and we show that the resulting phase and frequency dependence of the amplification follow the theory of parametric resonance. We expect that this phenomenon will be useful for both fundamental studies of dynamic systems with low dissipation and for increasing signal-to-noise ratio in practical applications such as gyroscopes.

  8. Radiation-induced heart injury

    International Nuclear Information System (INIS)

    Suzuki, Yoshihiko; Niibe, Hideo

    1975-01-01

    In order to identify radiation-induced heart injury and to differentiate it from heart disease, an attempt was made to clarify post-irradiation heart injury by investigating the histological changes which occur during the internal between the irradiation and the time of demonstrable histological changes. A study was made of 83 autopsies in which most of the primary neoplasms were breast cancers, lung cancers and mediastinal tumors. In 43 of these autopsies the heart had been irradiated. Sixty eight dd-strain mice were also used for microautoradiographic study. Histological changes in the heart were observed in 27 of the 43 cases receiving irradiation. The limit of the tolerance dose to the heart for indicating histological changes was 1220 ret in humans. The latent period without histological changes was 2.7 months after initiation of radiation therapy. Greater heart injury was observed after re-irradiation or after the combined therapy of radiation and chemotherapy especially mitomycin (MMC). The histological findings after treatment with MMC were similar to those of radiation-induced heart injury. Results of the study indicate that the damage is secondary to radiation-induced changes of the vascula connective tissue. (Evans, G.)

  9. Joint Instability and Osteoarthritis

    Directory of Open Access Journals (Sweden)

    Darryl Blalock

    2015-01-01

    Full Text Available Joint instability creates a clinical and economic burden in the health care system. Injuries and disorders that directly damage the joint structure or lead to joint instability are highly associated with osteoarthritis (OA. Thus, understanding the physiology of joint stability and the mechanisms of joint instability-induced OA is of clinical significance. The first section of this review discusses the structure and function of major joint tissues, including periarticular muscles, which play a significant role in joint stability. Because the knee, ankle, and shoulder joints demonstrate a high incidence of ligament injury and joint instability, the second section summarizes the mechanisms of ligament injury-associated joint instability of these joints. The final section highlights the recent advances in the understanding of the mechanical and biological mechanisms of joint instability-induced OA. These advances may lead to new opportunities for clinical intervention in the prevention and early treatment of OA.

  10. The Parametric Instability of Alfven Waves: Effects of Temperature Anisotropy

    Czech Academy of Sciences Publication Activity Database

    Tenerani, A.; Velli, M.; Hellinger, Petr

    2017-01-01

    Roč. 851, č. 2 (2017), 99/1-99/9 ISSN 0004-637X R&D Projects: GA ČR GA15-10057S Institutional support: RVO:67985815 Keywords : instabilities * plasmas * waves Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics OBOR OECD: Astronomy (including astrophysics,space science) Impact factor: 5.533, year: 2016

  11. Connections between classical and parametric network entropies.

    Directory of Open Access Journals (Sweden)

    Matthias Dehmer

    Full Text Available This paper explores relationships between classical and parametric measures of graph (or network complexity. Classical measures are based on vertex decompositions induced by equivalence relations. Parametric measures, on the other hand, are constructed by using information functions to assign probabilities to the vertices. The inequalities established in this paper relating classical and parametric measures lay a foundation for systematic classification of entropy-based measures of graph complexity.

  12. Radiation-induced gene expression in human subcutaneous fibroblasts is predictive of radiation-induced fibrosis

    DEFF Research Database (Denmark)

    Rødningen, Olaug Kristin; Børresen-Dale, Anne-Lise; Alsner, Jan

    2008-01-01

    BACKGROUND AND PURPOSE: Breast cancer patients show a large variation in normal tissue reactions after ionizing radiation (IR) therapy. One of the most common long-term adverse effects of ionizing radiotherapy is radiation-induced fibrosis (RIF), and several attempts have been made over the last...... years to develop predictive assays for RIF. Our aim was to identify basal and radiation-induced transcriptional profiles in fibroblasts from breast cancer patients that might be related to the individual risk of RIF in these patients. MATERIALS AND METHODS: Fibroblast cell lines from 31 individuals......-treated fibroblasts. Transcriptional differences in basal and radiation-induced gene expression profiles were investigated using 15K cDNA microarrays, and results analyzed by both SAM and PAM. RESULTS: Sixty differentially expressed genes were identified by applying SAM on 10 patients with the highest risk of RIF...

  13. Turing instability in reaction-diffusion systems with nonlinear diffusion

    Energy Technology Data Exchange (ETDEWEB)

    Zemskov, E. P., E-mail: zemskov@ccas.ru [Russian Academy of Sciences, Dorodnicyn Computing Center (Russian Federation)

    2013-10-15

    The Turing instability is studied in two-component reaction-diffusion systems with nonlinear diffusion terms, and the regions in parametric space where Turing patterns can form are determined. The boundaries between super- and subcritical bifurcations are found. Calculations are performed for one-dimensional brusselator and oregonator models.

  14. Transmission of chromosomal and instability via a chromosome irradiated with ionizing radiation

    International Nuclear Information System (INIS)

    Kodama, Seiji; Tanabe, Masateru; Shiraishi, Kazunori; Oshimura, Mitsuo

    2010-01-01

    We examined the stability of the transferred chromosome in 5 and 12 microcell hybrids including unirradiated human chromosomes 6 and 8, respectively, and 6 and 19 microcell hybrids including 4 Gy-irradiated human chromosomes 6 and 8, respectively. The transferred chromosome was structurally stable in most microcell hybrids transferred with the unirradiated chromosomes 6 and 8. In contrast, the 4 Gy-irradiated human chromosomes were unstable in 3 out of 6 hybrids (50%) with chromosome 6 and 3 out of 19 hybrids (16%) with chromosome 8, showing multiple aberrations in high frequencies (35∼98%). To know the cause of delayed chromosomal instability, intrachromosomal rearrangements of the human chromosome is investigated by subtelomere FISH in 17 microcell hybrids transferred with chromosomes 6 and 8. We found frequent intrachromosomal in 7 microcell hybrids (41%). However, no clear correlation was observed between the intrachromosomal rearrangements and the induction of delayed chromosomal instability by ionizing radiation

  15. Application of radiation-induced apoptosis in radiation oncology and radiation protection

    International Nuclear Information System (INIS)

    Crompton, N.E.A.; Emery, G.C.; Ozsahin, M.; Menz, R.; Knesplova, L.; Larsson, B.

    1997-01-01

    A rapid assay of the ability of lymphocytes to respond to radiation-induced damage is presented. Age and genetic dependence of radiation response have been quantified. The assay is sensitive to low doses of radiation. Its ability to assess the cytotoxic response of blood capillaries to radiation has been evaluated. (author)

  16. Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes

    Directory of Open Access Journals (Sweden)

    Philpott Michael P

    2010-02-01

    Full Text Available Abstract Background The human cell cycle transcription factor FOXM1 is known to play a key role in regulating timely mitotic progression and accurate chromosomal segregation during cell division. Deregulation of FOXM1 has been linked to a majority of human cancers. We previously showed that FOXM1 was upregulated in basal cell carcinoma and recently reported that upregulation of FOXM1 precedes malignancy in a number of solid human cancer types including oral, oesophagus, lung, breast, kidney, bladder and uterus. This indicates that upregulation of FOXM1 may be an early molecular signal required for aberrant cell cycle and cancer initiation. Results The present study investigated the putative early mechanism of UVB and FOXM1 in skin cancer initiation. We have demonstrated that UVB dose-dependently increased FOXM1 protein levels through protein stabilisation and accumulation rather than de novo mRNA expression in human epidermal keratinocytes. FOXM1 upregulation in primary human keratinocytes triggered pro-apoptotic/DNA-damage checkpoint response genes such as p21, p38 MAPK, p53 and PARP, however, without causing significant cell cycle arrest or cell death. Using a high-resolution Affymetrix genome-wide single nucleotide polymorphism (SNP mapping technique, we provided the evidence that FOXM1 upregulation in epidermal keratinocytes is sufficient to induce genomic instability, in the form of loss of heterozygosity (LOH and copy number variations (CNV. FOXM1-induced genomic instability was significantly enhanced and accumulated with increasing cell passage and this instability was increased even further upon exposure to UVB resulting in whole chromosomal gain (7p21.3-7q36.3 and segmental LOH (6q25.1-6q25.3. Conclusion We hypothesise that prolonged and repeated UVB exposure selects for skin cells bearing stable FOXM1 protein causes aberrant cell cycle checkpoint thereby allowing ectopic cell cycle entry and subsequent genomic instability. The aberrant

  17. Fundamental cavity impedance and longitudinal coupled-bunch instabilities at the High Luminosity Large Hadron Collider

    Directory of Open Access Journals (Sweden)

    P. Baudrenghien

    2017-01-01

    Full Text Available The interaction between beam dynamics and the radio frequency (rf station in circular colliders is complex and can lead to longitudinal coupled-bunch instabilities at high beam currents. The excitation of the cavity higher order modes is traditionally damped using passive devices. But the wakefield developed at the cavity fundamental frequency falls in the frequency range of the rf power system and can, in theory, be compensated by modulating the generator drive. Such a regulation is the responsibility of the low-level rf (llrf system that measures the cavity field (or beam current and generates the rf power drive. The Large Hadron Collider (LHC rf was designed for the nominal LHC parameter of 0.55 A DC beam current. At 7 TeV the synchrotron radiation damping time is 13 hours. Damping of the instability growth rates due to the cavity fundamental (400.789 MHz can only come from the synchrotron tune spread (Landau damping and will be very small (time constant in the order of 0.1 s. In this work, the ability of the present llrf compensation to prevent coupled-bunch instabilities with the planned high luminosity LHC (HiLumi LHC doubling of the beam current to 1.1 A DC is investigated. The paper conclusions are based on the measured performances of the present llrf system. Models of the rf and llrf systems were developed at the LHC start-up. Following comparisons with measurements, the system was parametrized using these models. The parametric model then provides a more realistic estimation of the instability growth rates than an ideal model of the rf blocks. With this modeling approach, the key rf settings can be varied around their set value allowing for a sensitivity analysis (growth rate sensitivity to rf and llrf parameters. Finally, preliminary measurements from the LHC at 0.44 A DC are presented to support the conclusions of this work.

  18. Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid

    Energy Technology Data Exchange (ETDEWEB)

    Polyzos, Aris [Environmental Health Centre, Environmental and occupational Toxicology Division, Health Canada, Tunney' s Pasture, P.L. 0803A, Ottawa, Ont., K1A 0L2 (Canada); Parfett, Craig [Environmental Health Centre, Environmental and occupational Toxicology Division, Health Canada, Tunney' s Pasture, P.L. 0803A, Ottawa, Ont., K1A 0L2 (Canada); Healy, Caroline [Environmental Health Centre, Environmental and occupational Toxicology Division, Health Canada, Tunney' s Pasture, P.L. 0803A, Ottawa, Ont., K1A 0L2 (Canada); Douglas, George R. [Environmental Health Centre, Environmental and occupational Toxicology Division, Health Canada, Tunney' s Pasture, P.L. 0803A, Ottawa, Ont., K1A 0L2 (Canada); Yauk, Carole L. [Environmental Health Centre, Environmental and occupational Toxicology Division, Health Canada, Tunney' s Pasture, P.L. 0803A, Ottawa, Ont., K1A 0L2 (Canada)]. E-mail: Carole_Yauk@hc-sc.gc.ca

    2006-06-25

    Expanded simple tandem repeat (ESTR) sequences have proven useful biomarkers to detect genotoxicity in vivo. Their high sensitivity has been used to assess environmentally relevant doses of mutagens such as ionizing radiation, DNA alkylating agents and airborne particulate pollution, for germline mutations in mouse assays. The mutagenic response involves size alteration of these ESTR loci induced by agents causing a variety of cellular damage. The mechanistic aspects of this induced instability remain unclear and have not been studied in detail. Mechanistic knowledge is important to help understand the relevance of increased ESTR mutation frequencies. In this study, we applied a murine cell culture system to examine induced response to four agents exhibiting different modes of toxic action including: N-nitroso-N-ethylurea (ENU), benzo(a)pyrene (BaP), okadaic acid and etoposide at slightly sub-toxic levels. We used single-molecule-polymerase chain reaction (SM-PCR) to assess the relative mutant frequency after 4-week chemical treatments at the Ms6-hm ESTR sequence of cultured C3H/10T1/2 cells (a mouse embryonic cell line). Increased mutation was observed with both 0.64 mM ENU (1.95-fold increase, P < 0.0001), 1 {mu}M benzo(a)pyrene (1.87-fold increase, P = 0.0006) and 3 nM etoposide (1.89-fold increase, P = 0.0003). The putative ESTR mutagen okadaic acid (1.27-fold increase, P = 0.2289), administered at 0.5 nM, did not affect the C3H/10T1/2 Ms6-hm locus. Therefore, agents inducing small and bulky adducts, and indirectly causing strand breaks through inhibition of topoisomerase, caused similar induction of instability at an ESTR locus at matched toxicities. As size spectra for induced mutations were identical, the data indicate that although these chemicals exhibit distinct modes of action, a similar indirect process is influencing ESTR instability. In contrast, a potent tumour promoter that is a kinase inhibitor does not contribute to induced ESTR instability in

  19. Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid

    International Nuclear Information System (INIS)

    Polyzos, Aris; Parfett, Craig; Healy, Caroline; Douglas, George R.; Yauk, Carole L.

    2006-01-01

    Expanded simple tandem repeat (ESTR) sequences have proven useful biomarkers to detect genotoxicity in vivo. Their high sensitivity has been used to assess environmentally relevant doses of mutagens such as ionizing radiation, DNA alkylating agents and airborne particulate pollution, for germline mutations in mouse assays. The mutagenic response involves size alteration of these ESTR loci induced by agents causing a variety of cellular damage. The mechanistic aspects of this induced instability remain unclear and have not been studied in detail. Mechanistic knowledge is important to help understand the relevance of increased ESTR mutation frequencies. In this study, we applied a murine cell culture system to examine induced response to four agents exhibiting different modes of toxic action including: N-nitroso-N-ethylurea (ENU), benzo(a)pyrene (BaP), okadaic acid and etoposide at slightly sub-toxic levels. We used single-molecule-polymerase chain reaction (SM-PCR) to assess the relative mutant frequency after 4-week chemical treatments at the Ms6-hm ESTR sequence of cultured C3H/10T1/2 cells (a mouse embryonic cell line). Increased mutation was observed with both 0.64 mM ENU (1.95-fold increase, P < 0.0001), 1 μM benzo(a)pyrene (1.87-fold increase, P = 0.0006) and 3 nM etoposide (1.89-fold increase, P = 0.0003). The putative ESTR mutagen okadaic acid (1.27-fold increase, P = 0.2289), administered at 0.5 nM, did not affect the C3H/10T1/2 Ms6-hm locus. Therefore, agents inducing small and bulky adducts, and indirectly causing strand breaks through inhibition of topoisomerase, caused similar induction of instability at an ESTR locus at matched toxicities. As size spectra for induced mutations were identical, the data indicate that although these chemicals exhibit distinct modes of action, a similar indirect process is influencing ESTR instability. In contrast, a potent tumour promoter that is a kinase inhibitor does not contribute to induced ESTR instability in cell

  20. Parametric instability of a functionally graded Timoshenko beam on Winkler's elastic foundation

    International Nuclear Information System (INIS)

    Mohanty, S.C.; Dash, R.R.; Rout, T.

    2011-01-01

    Highlights: → Winkler's elastic foundation enhances the stability of both FGO and FGSW beams with material properties distribution along the thickness as per power law and exponential law. → FGO beam with steel-rich bottom is more stable than a beam with aluminium-rich bottom for both the types of property distribution. → FGSW beam with the properties in FGM core varying as per power law becomes less stable with increase in core thickness. → Exponential variation of core properties enhances its stability with the increase in core thickness. - Abstract: This article presents an investigation of the dynamic stability of functionally graded ordinary (FGO) beam and functionally graded sandwich (FGSW) beam on Winkler's elastic foundation using finite element method. The material properties are assumed to follow both exponential and power law. It is found that the foundation enhances stability of the FGO beam for first three modes. The effect of distributions of material properties of the FGO beam on its parametric instability is investigated. It is found that the FGO beam with steel-rich bottom is more stable as compared to that with Al-rich bottom for all the three modes and for both the types of property distributions. The effect of property distribution on stability of FGSW beam with steel as bottom skin and alumina as top skin is also investigated. It is observed that the beam having properties in core according to exponential law is the most stable beam while the beam having properties in core as per power law with index 2.5 is the least stable beam. For an FGSW beam it is found that the increase in the thickness of FGM core makes the beam less stable when the properties in FGM vary as per power law whereas the stability of beam enhances with the increase of thickness of FGM core when the properties vary according to exponential law.

  1. On the parametrization of lateral dose profiles in proton radiation therapy

    CERN Document Server

    Embriaco, A

    2015-01-01

    Hadrontherapy requires a good knowledge of the physical interactions of the particles when they cross the biological tissue: one of the aspects that determine the characterization of the beam is the study of the lateral profile. We study different parametrizations for the lateral dose profile of protons beam in water considering different energies at different depth. We compare six functions: we start from the well known Gaussian and Double Gaussian parametrizations and also analyse more recent parametrization obtained with Triple Gaussian and Double Gaussian Lorentz-Cauchy functions. Finally we propose alternative parametrizations based on the Gauss-Rutherford and Gauss-Levy functions. The goal is to improve the performances of the actual treatment planning used in proton beam therapy by suggesting alternative approaches to the Gaussian description typically employed.

  2. Radiation-induced pneumothorax

    International Nuclear Information System (INIS)

    Epstein, D.M.; Littman, P.; Gefter, W.B.; Miller, W.T.; Raney, R.B. Jr.

    1983-01-01

    Pneumothorax is an uncommon complication of radiation therapy to the chest. The proposed pathogenesis is radiation-induced fibrosis promoting subpleural bleb formation that ruptures resulting in pneumothorax. We report on two young patients with primary sarcomas without pulmonary metastases who developed spontaneous pneumothorax after irradiation. Neither patient had antecedent radiographic evidence of pulmonary fibrosis

  3. Electron beam instabilities in gyrotron beam tunnels

    International Nuclear Information System (INIS)

    Pedrozzi, M.; Alberti, S.; Hogge, J.P.; Tran, M.Q.; Tran, T.M.

    1997-10-01

    Electron beam instabilities occurring in a gyrotron electron beam can induce an energy spread which might significantly deteriorate the gyrotron efficiency. Three types of instabilities are considered to explain the important discrepancy found between the theoretical and experimental efficiency in the case of quasi-optical gyrotrons (QOG): the electron cyclotron maser instability, the Bernstein instability and the Langmuir instability. The low magnetic field gradient in drift tubes of QOG makes that the electron cyclotron maser instability can develop in the drift tube at very low electron beam currents. Experimental measurements show that with a proper choice of absorbing structures in the beam tunnel, this instability can be suppressed. At high beam currents, the electrostatic Bernstein instability can induce a significant energy spread at the entrance of the interaction region. The induced energy spread scales approximately linearly with the electron beam density and for QOG one observes that the beam density is significantly higher than the beam density of an equivalent cylindrical cavity gyrotron. (author) figs., tabs., refs

  4. Radiation induced sarcomas of bone following therapeutic radiation

    International Nuclear Information System (INIS)

    Kim, J.H.; Chu, F.C.H.; Woodward, H.Q.; Huvos, A.

    1983-01-01

    Because of new therapeutic trends of multi-modality and the importance of late effects, we have updated our series of radiation induced bone sarcomas seen at Memorial Sloan-Kettering Cancer Center over the past four decades. A total of 37 cases of bone sarcoma arising from normal bone in the irradiated field was analyzed. The median for latent period from irradiation to diagnosis of bone sarcoma was 11 years with a minimum latent period of four years. The median radiation dose for the bone sarcoma was 6000 rad in 6 weeks with a minimum total radiation dose of 3000 rad in 3 weeks. We have found nine patients who developed bone sarcomas in the radiation field after successful treatment of Hodgkin's disease. Criteria for radiation induced bone sarcomas and the magnitude of the risk of bone sarcomas are briefly discussed

  5. Double parametric resonance for matter-wave solitons in a time-modulated trap

    International Nuclear Information System (INIS)

    Baizakov, Bakhtiyor; Salerno, Mario; Filatrella, Giovanni; Malomed, Boris

    2005-01-01

    We analyze the motion of solitons in a self-attractive Bose-Einstein condensate, loaded into a quasi-one-dimensional parabolic potential trap, which is subjected to time-periodic modulation with an amplitude ε and frequency Ω. First, we apply the variational approximation, which gives rise to decoupled equations of motion for the center-of-mass coordinate of the soliton, ξ(t), and its width a(t). The equation for ξ(t) is the ordinary Mathieu equation (ME) (it is an exact equation that does not depend on the adopted ansatz), the equation for a(t) being a nonlinear generalization of the ME. Both equations give rise to the same map of instability zones in the (ε,Ω) plane, generated by the parametric resonances (PRs), if the instability is defined as the onset of growth of the amplitude of the parametrically driven oscillations. In this sense, the double PR is predicted. Direct simulations of the underlying Gross-Pitaevskii equation give rise to a qualitatively similar but quantitatively different stability map for oscillations of the soliton's width a(t). In the direct simulations, we identify the soliton dynamics as unstable if the instability (again, realized as indefinite growth of the amplitude of oscillations) can be detected during a time comparable with, or smaller than, the lifetime of the condensate (therefore accessible to experimental detection). Two-soliton configurations are also investigated. It is concluded that multiple collisions between solitons are elastic, and they do not affect the instability borders

  6. Radiation-induced bone neoplasma in facial cranium

    Energy Technology Data Exchange (ETDEWEB)

    Zomer-Drozda, J; Buraczewska-Lipinska, H; Buraczewski, J [Instytut Onkologii, Warsaw (Poland)

    1976-01-01

    Radiation-induced bone neoplasms in the region of facial cranium account for about 40% of all radiation-induced tumours of bones, although the number of cases with lesions irradiated in this area is proportionally much lower than the number of cases treated with radiotherapy in other parts of the body. Four personal cases of radiation-induced tumours with complicated course are reported. Attention is called to the value of radiological investigations in the diagnosis of bone diseases and in differential diagnosis of radiation-induced tumours of bones.

  7. Radiation parametric generation in non-linear crystals

    International Nuclear Information System (INIS)

    Pacheco, M.T.; Pereira, M.A.C.Q.

    1983-01-01

    A short historical development review is presented on the optical parametric oscillators. Analysis on behaviour of the simple resonant oscillators (SRO), double resonant oscillators (DRO) and ring resonant oscillators (RRO), in the plane wave pumping approximation is shown. Comparision between the three oscillators types is given. (Author) [pt

  8. Theory and Observations of Microbunching Instability in Electron Machines

    International Nuclear Information System (INIS)

    Stupakov, Gennady V.

    2003-01-01

    For not very short bunches, the coherent synchrotron radiation (CSR) is usually suppressed by the shielding effect of the conducting walls of the vacuum chamber. However an initial density fluctuation in the beam with a characteristic length much shorter than the bunch length can radiate coherently. If the radiation-reaction force drives growth of the initial fluctuation, one can expect an instability which leads to micro-bunching of the beam and increased coherent radiation at short wavelengths. It has recently been realized that such an instability can play an important role in electron/positron rings where it often manifests itself as a bursting of radiation in the range of hundreds of gigahertz or terahertz. This instability can also be a source of an undesirable emittance growth in bunch compressors used in the next generation short-wavelength FELs. In this paper, we review progress in theoretical studies and numerical simulations of the microbunching instability and show connection of the theory to recent observations in electron machines

  9. Radiative instabilities of atmospheric jets and boundary layers

    International Nuclear Information System (INIS)

    Candelier, J.

    2010-01-01

    Complex flows occur in the atmosphere and they can be source of internal gravity waves. We focus here on the sources associated with radiative and shear (or Kelvin-Helmholtz) instabilities. Stability studies of shear layers in a stably stratified fluid concern mainly cases where shear and stratification are aligned along the same direction. In these cases, Miles (1961) and Howard (1961) found a necessary condition for stability based on the Richardson number: Ri ≥ 1/4. In this thesis, we show that this condition is not necessary when shear and stratification are not aligned: we demonstrate that a two-dimensional planar Bickley jet can be unstable for all Richardson numbers. Although the most unstable mode remains 2D, we show there exists an infinite family of 3D unstable modes exhibiting a radiative structure. A WKBJ theory is found to provide the main characteristics of these modes. We also study an inviscid and stratified boundary layer over an inclined wall with non-Boussinesq and compressible effects. We show that this flow is unstable as soon as the wall is not horizontal for all Froude numbers and that strongly stratified 3D perturbations behave exactly like compressible 2D perturbations. Applications of the results to the jet stream and the atmospheric boundary layer are proposed. (author) [fr

  10. A challenge to mutation theory of radiation carcinogenesis

    International Nuclear Information System (INIS)

    Watanabe, Masami

    2006-01-01

    This paper presents an objection against the commonly accepted mutation theory in radiation carcinogenesis. First, author's studies of X-ray irradiated syrian hamster embryo (SHE) cells on malignant morphological changes and mutational change of HGPRT gene showed that the changing patterns were quite different, and as well, other studies in mice gave the essentially similar results. Thus radiation-induced carcinogenesis in cells does not simply occur by an accumulation of radiation-induced mutation. Second, as cultured cells usually used for oncogenesis studies already have the infinitively proliferative ability, the author used the primary cell culture obtained from the rodent embryo. Even those cells became immortal to be cancerous after repeated culture passage with the higher frequency of 10 3 -10 4 relative to somatic cell mutation. Cells thus seem to be easily changeable to cancerous ones. Bystander effect can cause transformation in non-irradiated cells and genetic instability by radiation can form the potentially unstable chromatin region, which induces telomere instability. The author has found that, while short-lived radicals yielded by X-ray irradiation attack DNA to induce cell death and chromosome aberration, long-lived radicals in biomolecules do not, but can cause mutation and carcinogenesis, which are reduced by vitamine C supplementation. The author concludes that the primary target in the radiation carcinogenesis in cells and even in the whole individuals is conceivably protein and not DNA. (T.I.)

  11. Radiation-Induced Epigenetic Alterations after Low and High LET Irradiations

    Energy Technology Data Exchange (ETDEWEB)

    Aypar, Umut; Morgan, William F.; Baulch, Janet E.

    2011-02-01

    Epigenetics, including DNA methylation and microRNA (miRNA) expression, could be the missing link in understanding the delayed, non-targeted effects of radiation including radiationinduced genomic instability (RIGI). This study tests the hypothesis that irradiation induces epigenetic aberrations, which could eventually lead to RIGI, and that the epigenetic aberrations induced by low linear energy transfer (LET) irradiation are different than those induced by high LET irradiations. GM10115 cells were irradiated with low LET x-rays and high LET iron (Fe) ions and evaluated for DNA damage, cell survival and chromosomal instability. The cells were also evaluated for specific locus methylation of nuclear factor-kappa B (NFκB), tumor suppressor in lung cancer 1 (TSLC1) and cadherin 1 (CDH1) gene promoter regions, long interspersed nuclear element 1 (LINE-1) and Alu repeat element methylation, CpG and non-CpG global methylation and miRNA expression levels. Irradiated cells showed increased micronucleus induction and cell killing immediately following exposure, but were chromosomally stable at delayed times post-irradiation. At this same delayed time, alterations in repeat element and global DNA methylation and miRNA expression were observed. Analyses of DNA methylation predominantly showed hypomethylation, however hypermethylation was also observed. MiRNA shown to be altered in expression level after x-ray irradiation are involved in chromatin remodeling and DNA methylation. Different and higher incidence of epigenetic changes were observed after exposure to low LET x-rays than high LET Fe ions even though Fe ions elicited more chromosomal damage and cell killing. This study also shows that the irradiated cells acquire epigenetic changes even though they are chromosomally stable suggesting that epigenetic aberrations may arise in the cell without initiating RIGI.

  12. Regulation of radiation-induced protein kinase Cδ activation in radiation-induced apoptosis differs between radiosensitive and radioresistant mouse thymic lymphoma cell lines

    International Nuclear Information System (INIS)

    Nakajima, Tetsuo; Yukawa, Osami; Tsuji, Hideo; Ohyama, Harumi; Wang, Bing; Tatsumi, Kouichi; Hayata, Isamu; Hama-Inaba, Hiroko

    2006-01-01

    Protein kinase Cδ (PKCδ) has an important role in radiation-induced apoptosis. The expression and function of PKCδ in radiation-induced apoptosis were assessed in a radiation-sensitive mouse thymic lymphoma cell line, 3SBH5, and its radioresistant variant, XR223. Rottlerin, a PKCδ-specific inhibitor, completely abolished radiation-induced apoptosis in 3SBH5. Radiation-induced PKCδ activation correlated with the degradation of PKCδ, indicating that PKCδ activation through degradation is involved in radiation-induced apoptosis in radiosensitive 3SBH5. In radioresistant XR223, radiation-induced PKCδ activation was lower than that in radiosensitive 3SBH5. Cytosol PKCδ levels in 3SBH5 decreased markedly after irradiation, while those in XR223 did not. There was no apparent change after irradiation in the membrane fractions of either cell type. In addition, basal cytosol PKCδ levels in XR223 were higher than those in 3SBH5. These results suggest that the radioresistance in XR223 to radiation-induced apoptosis is due to a difference in the regulation of radiation-induced PKCδ activation compared to that of 3SBH5. On the other hand, Atm -/- mouse thymic lymphoma cells were more radioresistant to radiation-induced apoptosis than wild-type mouse thymic lymphoma cells. Irradiated wild-type cells, but not Atm -/- cells, had decreased PKCδ levels, indicating that the Atm protein is involved in radiation-induced apoptosis through the induction of PKCδ degradation. The decreased Atm protein levels induced by treatment with Atm small interfering RNA had no effect on radiation-induced apoptosis in 3SBH5 cells. These results suggest that the regulation of radiation-induced PKCδ activation, which is distinct from the Atm-mediated cascade, determines radiation sensitivity in radiosensitive 3SBH5 cells

  13. KC-A Kinectic computer code for investigation of parametric plasma instabilities

    International Nuclear Information System (INIS)

    Olshansky, V.

    1995-07-01

    In the frame of a joint research program of the Institute of Plasma Physics of the NationaI Science Center 'Kharkov Institute of Physics and Technology' (Kh IPT), Ukraine, and the plasma physics group of the Austrian Research Center Seibersdorf (FZS) a kinetic computer code with the acronym KC for investigation of paramarametric plasma instabilities has been implemented at the computer facilities of FZS as a starting point for further research in this field. This code based on a macroparticle technique is appropriate for studying the evolution of instabilities in a turbulent plasma including saturation. The results can be of interest for heating of tokamaks of the next generation, i.g. ITER. The present report describes the underlying physical models and numerical methods as well as the code structure and how to use the code as a reference of forthcoming joint papers. (author)

  14. 3 cases of radiation-induced sarcoma

    International Nuclear Information System (INIS)

    Shiba, Keiichiro; Fukuma, Hisatoshi; Beppu, Yasuo; Hirota, Teruyuki; Shinohara, Norio.

    1982-01-01

    Criteria for the diagnosis of radiation-induced sarcoma have been previously described. All cases must have a history of irradiation and the second neoplasm must have arisen in the area of the radiation field. A latent period of several years must have elapsed after irradiation before clinical evidence of a second malignant neoplasm. Most important thing is that, all suspected cases must have been proved histologically. We have experienced 3 cases of radiation-induced sarcoma, they were 42-years-old man who developed an osteosarcoma of the lumbar spine at the field of postoperative irradiation for seminoma 7 years previously, 69-years-old woman who developed a malignant fibrous histiocytoma of the buttock at the field of radical radiation for uterine carcinoma 7 years previously and 59-years-old woman who developed an extraskeletal osteosarcoma of the abdominal wall at the field of postoperative irradiation for uterine sarcoma 7 years previously. The last case is very rare and only 8 cases of radiation-induced extraskeletal osteosarcoma have been reported. Since there has been a definite trend in the treatment of cancer toward employing radiation for more favorable cases, in addition to technical improvements in the administration of radiotherapy and more modern equipment, survival data may have been altered considerably in many malignant tumors. Accordingly, more radiation-induced tumors may be encountered in the future. The clinical presentation and histopathology of these radiation-induced sarcomas are presented with a review of the literature. (author)

  15. Modulation of radiation induced DNA damage by natural products in hemopoietic tissue of mice

    International Nuclear Information System (INIS)

    Jayakumar, S.; Bhilwade, H.N.; Chaubey, R.C.

    2014-01-01

    Ionizing radiation is known to induce oxidative stress through generation of ROS leading to a variety of DNA lesions. However, the most dangerous DNA lesions which are responsible for the origin of lethal effects, mutagenesis, genomic instability and carcinogenesis are the DSBs. During recent years efforts are being made to identify phytochemicals, antioxidants or neutraxeuticals which can reduce harmful effect of radiation during accidental exposure or prevent normal tissue injury during radiotherapy. In the present study, we have investigated the radioprotective role of curcumin, a dietary antioxidant, taurine, malabaricone-C, and umbelliferone, for their radioprotective properties in hemopoietic cells of mice. Groups of mice-were fed 1% of curcumin in diet for three weeks. Similarly other groups of mice were injected i.p. with 50 mg/kg body weight of taurine for five consecutive days. After the completion of the treatment mice pre-treated with curcumin and taurine were exposed to 3 Gy of gamma rays. Malabaricone-C was tested for its radiomodulation potential in vitro, in spleenocytes of mouse. Spleenocytes were isolated and treated with different concentrations (0.5-25 ìM) of malabaricone-C. Immediately after irradiation, alkaline comet assay were performed using standard procedures. Twenty four post radiation exposure mice were sacrificed for micronucleus test. Results of these studies showed significant reduction in DNA damage by curcumin. The micronucleus data showed marginal increase in the frequency of micronucleated erythrocytes in curcumin fed group as compared to the controls. Mice receiving curcumin for 3 weeks in diet followed by gamma radiation (3 Gy), showed approximately 50% reduction in the frequency of micro nucleated polychromatic erythrocytes. Pre-treatment of mice with taurine significantly (p < 0.01) reduced the frequency of gamma rays induced mn-PCEs in bone marrow tissue. Malabaricone-C at 1.5 ìM concentration showed very good protection

  16. Numerical study of jets secondary instabilities

    International Nuclear Information System (INIS)

    Brancher, Pierre

    1996-01-01

    The work presented in this dissertation is a contribution to the study of the transition to turbulence in open shear flows. Results from direct numerical simulations are interpreted within the framework of hydrodynamic stability theory. The first chapter is an introduction to the primary and secondary instabilities observed in jets and mixing layers. The numerical method used in the present study is detailed in the second chapter. The dynamics of homogeneous circular jets subjected to stream wise and azimuthal perturbations are investigated in the third chapter. A complete scenario describing the evolution of the jet is proposed with emphasis on the dynamics of vorticity within the flow. In the fourth chapter a parametric study reveals a three-dimensional secondary instability mainly controlled in the linear regime by the Strouhal number of the primary instability. In the nonlinear regime the dynamics of the azimuthal harmonies are described by means of model equations and are linked to the formation of stream wise vortices in the braid. The fifth chapter is dedicated to the convective or absolute nature of the secondary instabilities in plane shear layers. It is shown that there are flow configurations for which the two-dimensional secondary instability (pairing) is absolute even though the primary instability (Kelvin-Helmholtz) is convective. Some preliminary results concerning the three-dimensional secondary instabilities arc presented at the end of this chapter. The last chapter summarizes the main results and examines possible extensions of this work. (author) [fr

  17. Epigenetic mechanism of radiation carcinogenesis

    International Nuclear Information System (INIS)

    Niwa, Ohtsura

    1995-01-01

    Carcinogenic action of radiations has long been thought to be due to its mutagenic activity. Since DNA damage is induced and distributes in a stochastic fashion, radiation induction of cancers was also assumed to follow a stochastic kinetics. However, recent progress in radiation research has revealed that some features of radiation carcinogenesis are not explainable by the simple action of radiation as a DNA damaging and mutagenic agent. Firstly, frequencies of radiation-induced transformation in vitro and radiation-induced mammary cancers in rats are too high to be accounted for by the frequency of radiation-induced mutation. Secondly, trans-generation carcinogenesis among F1 mice born to irradiated parents occurs also much more frequently than to be predicted by the frequency of radiation induced germline mutation. Thirdly, multistage carcinogenesis theory predicts that carcinogens give hits to the target cells so as to shorten the latency of cancers. However, latencies of radiation induced solid cancers among atomic bomb survivors are similar to those of the control population. Fourthly, although radiation elevates the frequency of cancers, the induced cancers seem to share the same spectrum of cancer types as in the unirradiated control populations. This suggests that radiation induces cancer by enhancement of the spontaneous carcinogenesis process. These data suggest that the first step of radiation carcinogenesis may not be the direct induction of mutation. Radiation may induce genetic instability which increases the spontaneous mutation rate in the cells to produce carcinogenic mutations. Growth stimulatory effect of radiation may also contribute to the process. Thus, epigenetic, but not genetic effect of radiation might better contribute in the process of carcinogenesis. (author)

  18. Critical target and dose and dose-rate responses for the induction of chromosomal instability by ionizing radiation

    Science.gov (United States)

    Limoli, C. L.; Corcoran, J. J.; Milligan, J. R.; Ward, J. F.; Morgan, W. F.

    1999-01-01

    To investigate the critical target, dose response and dose-rate response for the induction of chromosomal instability by ionizing radiation, bromodeoxyuridine (BrdU)-substituted and unsubstituted GM10115 cells were exposed to a range of doses (0.1-10 Gy) and different dose rates (0.092-17.45 Gy min(-1)). The status of chromosomal stability was determined by fluorescence in situ hybridization approximately 20 generations after irradiation in clonal populations derived from single progenitor cells surviving acute exposure. Overall, nearly 700 individual clones representing over 140,000 metaphases were analyzed. In cells unsubstituted with BrdU, a dose response was found, where the probability of observing delayed chromosomal instability in any given clone was 3% per gray of X rays. For cells substituted with 25-66% BrdU, however, a dose response was observed only at low doses (1.0 Gy), the incidence of chromosomal instability leveled off. There was an increase in the frequency and complexity of chromosomal instability per unit dose compared to cells unsubstituted with BrdU. The frequency of chromosomal instability appeared to saturate around approximately 30%, an effect which occurred at much lower doses in the presence of BrdU. Changing the gamma-ray dose rate by a factor of 190 (0.092 to 17.45 Gy min(-1)) produced no significant differences in the frequency of chromosomal instability. The enhancement of chromosomal instability promoted by the presence of the BrdU argues that DNA comprises at least one of the critical targets important for the induction of this end point of genomic instability.

  19. Chromosomal damages and mutagenesis in mammalian and human cells induced by ionizing radiations with different LET

    International Nuclear Information System (INIS)

    Govorun, R.D.

    1997-01-01

    On the basis of literature and proper data the inference was made about essential role of structural chromosomal (and gene) damages in spontaneous and radiation-induced mutagenesis of mammalian and human cells on HPRT-loci. The evidences of increasing role of these damages in the mutagenesis after the influence of ionizing radiations with high LET are adduced. The consequences of HPRT-gene damages have been examined hypothetically. The geterogeneity of mutant subclones on their cytogenetical properties were revealed experimentally. The data reflect a phenomenon of the reproductive chromosomal instability in many generations of mutant cell. The mutagenesis of mammalian cells is also accompanied by the impairment of chromosome integrity with high probability as a stage of appropriate genome reorganization because of changed vital conditions

  20. Inhibiting extracellular matrix metalloproteinase inducer maybe beneficial for diminishing the atherosclerotic plaque instability

    Directory of Open Access Journals (Sweden)

    Xie S

    2009-01-01

    Full Text Available Atherosclerotic plaque rupture and local thrombosis activation in the artery cause acute serious incidents such as acute coronary syndrome and stroke. The exact mechanism of plaque rupture remains unclear but excessive degradation of the extracellular matrix scaffold by matrix-degrading metalloproteinases (MMPs has been implicated as one of the major molecular mechanisms in this process. Convincing evidence is available to prove that extracellular matrix metalloproteinase inducer (EMMPRIN induces MMP expression and is involved in the inflammatory responses in the artery wall. The inflammation and MMPs have been shown to play a critical role for atherosclerotic lesion development and progression. More recent data showed that increased EMMPRIN expression was associated with vulnerable atherosclerotic lesions. Therefore, we speculate that EMMPRIN may be pivotal for atherosclerotic plaque instability, and hence inhibition of EMMPRIN expression could be a promising approach for the prevention or treatment of atheroma instability.

  1. Nonlinear instabilities induced by the F coil power amplifier at FTU: Modeling and control

    International Nuclear Information System (INIS)

    Zaccarian, L.; Boncagni, L.; Cascone, D.; Centioli, C.; Cerino, S.; Gravanti, F.; Iannone, F.; Mecocci, F.; Pangione, L.; Podda, S.; Vitale, V.; Vitelli, R.

    2009-01-01

    In this paper we focus on the instabilities caused by the nonlinear behavior of the F coil current amplifier at FTU. This behavior induces closed-loop instability of the horizontal position stabilizing loop whenever the requested current is below the circulating current level. In the paper we first illustrate a modeling phase where nonlinear dynamics are derived and identified to reproduce the open-loop responses measured by the F coil current amplifier. The derived model is shown to successfully reproduce the experimental behavior by direct comparison with experimental data. Based on this dynamic model, we then reproduce the closed-loop scenario of the experiment and show that the proposed nonlinear model successfully reproduces the nonlinear instabilities experienced in the experimental sessions. Given the simulation setup, we next propose a nonlinear control solution to this instability problem. The proposed solution is shown to recover stability in closed-loop simulations. Experimental tests are scheduled for the next experimental campaign after the FTU restart.

  2. Irradiation-induced instability of MnS precipitates and its possible contribution to IASCC in light water reactors

    International Nuclear Information System (INIS)

    Garner, F.A.; Greenwood, L.R.; Chung, H.M.

    1997-01-01

    Although a number of candidate mechanisms have been proposed to participate in the IASCC phenomenon, it is not clear at this time that all of the contributing mechanisms have been identified. A new mechanism was proposed by Garner and Greenwood as a potential contribution to IASCC that involves the radiation-induced release into solution of sulphur and other deleterious elements that are normally concentrated into MnS precipitates. The instability arises from the combined action of the transmutation of manganese to iron, cascade-induced mixing and the very strong action of the inverse Kirkendall effect. The latter mechanism acts as a pump to export manganese from the precipitate surface and to replace it primarily with iron, as well as smaller amounts of chromium, nickel and other lesser elements. Evidence previously presented by Chung and coworkers appears to show that MnS precipitates in typical 300 series stainless steels become progressively depleted in manganese and enriched with iron as irradiation proceeds in boiling water reactor neutron spectra. It is shown in this paper that transmutation alone is insufficient to produce the observed behavior

  3. Biological effects of low-dose ionizing radiation exposure

    International Nuclear Information System (INIS)

    Reinoehl-Kompa, Sabine; Baldauf, Daniela; Heller, Horst

    2009-01-01

    The report on the meeting of the Strahlenschutzkommission 2007 concerning biological effects of low-dose ionizing radiation exposure includes the following contributions: Adaptive response. The importance of DNA damage mechanisms for the biological efficiency of low-energy photons. Radiation effects in mammography: the relative biological radiation effects of low-energy photons. Radiation-induced cataracts. Carcinomas following prenatal radiation exposure. Intercellular apoptosis induction and low-dose irradiation: possible consequences for the oncogenesis control. Mechanistic models for the carcinogenesis with radiation-induced cell inactivation: application to all solid tumors in the Japanese atomic bomb survivors. Microarrays at low radiation doses. Mouse models for the analysis of biological effects of low-dose ionizing radiation. The bystander effect: observations, mechanisms and implications. Lung carcinoma risk of Majak workers - modeling of carcinogenesis and the bystander effect. Microbeam studies in radiation biology - an overview. Carcinogenesis models with radiation-induced genomic instability. Application to two epidemiological cohorts.

  4. Radiation-induced radical ions in calcium sulfite

    Science.gov (United States)

    Bogushevich, S. E.

    2006-07-01

    We have used EPR to study the effect of γ radiation on calcium sulfite. We have observed and identified the radiation-induced radical ions SO 2 - (iso) with g = 2.0055 and SO 2 - (orth-1) with g1 = 2.0093, g2 = 2.0051, g3 = 2.0020, identical to the initial and thermally induced SO 2 - respectively, SO 3 - (iso) with g = 2.0031 and SO 3 - (axial) with g⊥ = 2.0040, g∥ = 2.0023, identical to mechanically induced SO 3 - . We have established the participation of radiation-induced radical ions SO 3 - in formation of post-radiation SO 2 - .

  5. Convective instability of sludge storage under evaporation and solar radiation

    Science.gov (United States)

    Tsiberkin, Kirill; Tatyana, Lyubimova

    2014-05-01

    The sludge storages are an important part of production cycle at salt manufacturing, water supply, etc. A quality of water in the storage depends on mixing of pure water and settled sediment. One of the leading factors is thermal convection. There are two main mechanisms of the layer instability exist. First, it is instability of water due to evaporation from the free surface [1]. It cools the water from upside, increases the particles concentration and leads to the instability in the near-surface layer. Second, the sediment absorbs a solar radiation and heats the liquid from below making it unstable in the near-bottom area. We assume the initial state is the mechanical equilibrium. The water and sediment particles are motionless, the sediment forms a uniform sludge layer of thickness z0, there are no evaporation and heating by solar energy, and the temperature has a linear profile is determined by fixed upper and bottom temperatures of the layer. Taking into account the evaporation and solar radiation absorption, we obtain a non-stationary solution for the temperature using Fourier series method. The local temperature gradients increases rapidly with time, and local Rayleigh number can be estimated by thermal conduction length Lt: Raloc(z,t) = gβ(δT(z,t)/δz)L4t-/νΞ , Lt ~ √Ξt, (1) where g is gravity acceleration, β, ν and Ξ are thermal volume expansion coefficient, kinematic viscosity and thermal conductivity of the liquid, respectively. Raloc* reaches the critical value at finite time t* and water motion begins. The maximal power of solar radiation in visible band equals 230 Wt/m2 at the latitude of "Uralkalii" salt manufacturer (Berezniki, Perm Region, Russian Federation). We neglect IR and UV radiation because of its huge absorption by water [2]. The evaporation speed is found using results for shallow water reservoir [3] and meteorological data for Berezniki [4]. We get the t*~ 6 · 102 s (10 min) for the layer of 1 m depth and t*~ 2 · 103 s (40

  6. Radiation- induced aneuploidy in mammalian germ cells

    International Nuclear Information System (INIS)

    Tease, C.

    1989-01-01

    The ability of ionizing radiation to induce aneuploidy in mammalian germ cells has been investigated experimentally in the laboratory mouse using a variety of cytogenetic and genetic methods. These studies have provided unambiguous evidence of induced nondisjunction in both male and female germ cells when the effect of irradiation is screened in meiotic cells or preimplantation embryos. In contrast, however, cytogenetic analyses of post-implantation embryos and genetic assays for induced chromosome gains have not found a significant radiation effect. These apparently contradictory findings may be reconciled if (a) radiation induces tertiary rather than primary trisomy, or (b) induces embryo-lethal genetic damage, such as deletions, in addition to numerical anomalies. Either or both of these explanations may account for the apparent loss during gestation of radiation-induced trisomic embryos. Extrapolating from the information so far available, it seems unlikely that environmental exposure to low doses if low dose rate radiation will result in a detectable increase in the rate of aneuploidy in the human population. (author)

  7. Propagating self-sustained annealing of radiation-induced interstitial complexes

    International Nuclear Information System (INIS)

    Bokov, P M; Selyshchev, P A

    2016-01-01

    A propagating self-sustained annealing of radiation induced defects as a result of thermal-concentration instability is studied. The defects that are considered in the model are complexes. Each of them consists of one atom of impunity and of one interstitial atom. Crystal with defects has extra energy which is transformed into heat during defect annealing. Simulation of the auto-wave of annealing has been performed. The front and the speed of the auto-wave have been obtained. It is shown that annealing occurs in a narrow region of time and space. There are two kinds of such annealing behaviour. In the first case the speed of the auto-wave oscillates near its constant mean value and the front of temperature oscillates in a complex way. In the second case the speed of propagation is constant and fronts of temperature and concentration look like sigmoid functions. (paper)

  8. Radiation-induced camptocormia and dropped head syndrome. Review and case report of radiation-induced movement disorders

    Energy Technology Data Exchange (ETDEWEB)

    Seidel, Clemens; Kuhnt, Thomas; Kortmann, Rolf-Dieter; Hering, Kathrin [Leipzig University, Department of Radiotherapy and Radiation Oncology, Leipzig (Germany)

    2015-10-15

    In recent years, camptocormia and dropped head syndrome (DHS) have gained attention as particular forms of movement disorders. Camptocormia presents with involuntary forward flexion of the thoracolumbar spine that typically increases during walking or standing and may severely impede walking ability. DHS is characterized by weakness of the neck extensors and a consecutive inability to extend the neck; in severe cases the head is fixed in a ''chin to chest position.'' Many diseases may underlie these conditions, and there have been some reports about radiation-induced camptocormia and DHS. A PubMed search with the keywords ''camptocormia,'' ''dropped head syndrome,'' ''radiation-induced myopathy,'' ''radiation-induced neuropathy,'' and ''radiation-induced movement disorder'' was carried out to better characterize radiation-induced movement disorders and the radiation techniques involved. In addition, the case of a patient developing camptocormia 23 years after radiation therapy of a non-Hodgkin's lymphoma of the abdomen is described. In total, nine case series of radiation-induced DHS (n = 45 patients) and - including our case - three case reports (n = 3 patients) about radiogenic camptocormia were retrieved. Most cases (40/45 patients) occurred less than 15 years after radiotherapy involving extended fields for Hodgkin's disease. The use of wide radiation fields including many spinal segments with paraspinal muscles may lead to radiation-induced movement disorders. If paraspinal muscles and the thoracolumbar spine are involved, the clinical presentation can be that of camptocormia. DHS may result if there is involvement of the cervical spine. To prevent these disorders, sparing of the spine and paraspinal muscles is desirable. (orig.) [German] In den letzten Jahren haben Bewegungsstoerungen von Wirbelsaeule und paraspinaler Muskulatur in

  9. Feedback-enhanced sensitivity in optomechanics

    DEFF Research Database (Denmark)

    Harris, Glen I.; Andersen, Ulrik L.; Knittel, Joachim

    2012-01-01

    The intracavity power, and hence sensitivity, of optomechanical sensors is commonly limited by parametric instability. Here we characterize the degradation of sensitivity induced by parametric instability in a micron-scale cavity optomechanical system. Feedback via optomechanical transduction...... and electrical gradient force actuation is applied to suppress the parametric instability. As a result a 5.4-fold increase in mechanical motion transduction sensitivity is achieved to a final value of 1.9×10-18 mHz-1/2....

  10. Moisture-induced solid state instabilities in α-chymotrypsin and their reduction through chemical glycosylation

    Directory of Open Access Journals (Sweden)

    Solá Ricardo J

    2010-08-01

    Full Text Available Abstract Background Protein instability remains the main factor limiting the development of protein therapeutics. The fragile nature (structurally and chemically of proteins makes them susceptible to detrimental events during processing, storage, and delivery. To overcome this, proteins are often formulated in the solid-state which combines superior stability properties with reduced operational costs. Nevertheless, solid protein pharmaceuticals can also suffer from instability problems due to moisture sorption. Chemical protein glycosylation has evolved into an important tool to overcome several instability issues associated with proteins. Herein, we employed chemical glycosylation to stabilize a solid-state protein formulation against moisture-induced deterioration in the lyophilized state. Results First, we investigated the consequences of moisture sorption on the stability and structural conformation of the model enzyme α-chymotrypsin (α-CT under controlled humidity conditions. Results showed that α-CT aggregates and inactivates as a function of increased relative humidity (RH. Furthermore, α-CT loses its native secondary and tertiary structure rapidly at increasing RH. In addition, H/D exchange studies revealed that α-CT structural dynamics increased at increasing RH. The magnitude of the structural changes in tendency parallels the solid-state instability data (i.e., formation of buffer-insoluble aggregates, inactivation, and loss of native conformation upon reconstitution. To determine if these moisture-induced instability issues could be ameliorated by chemical glycosylation we proceeded to modify our model protein with chemically activated glycans of differing lengths (lactose and dextran (10 kDa. The various glycoconjugates showed a marked decrease in aggregation and an increase in residual activity after incubation. These stabilization effects were found to be independent of the glycan size. Conclusion Water sorption leads to

  11. Controlling Parametric Resonance

    DEFF Research Database (Denmark)

    Galeazzi, Roberto; Pettersen, Kristin Ytterstad

    2012-01-01

    the authors review the conditions for the onset of parametric resonance, and propose a nonlinear control strategy in order to both induce the resonant oscillations and to stabilize the unstable motion. Lagrange’s theory is used to derive the dynamics of the system and input–output feedback linearization...

  12. Cavitation instabilities and rotordynamic effects in turbopumps and hydroturbines turbopump and inducer cavitation, experiments and design

    CERN Document Server

    Salvetti, Maria

    2017-01-01

    The book provides a detailed approach to the physics, fluid dynamics, modeling, experimentation and numerical simulation of cavitation phenomena, with special emphasis on cavitation-induced instabilities and their implications on the design and operation of high performance turbopumps and hydraulic turbines. The first part covers the fundamentals (nucleation, dynamics, thermodynamic effects, erosion) and forms of cavitation (attached cavitation, cloud cavitation, supercavitation, vortex cavitation) relevant to hydraulic turbomachinery, illustrates modern experimental techniques for the characterization, visualization and analysis of cavitating flows, and introduces the main aspects of the hydrodynamic design and performance of axial inducers, centrifugal turbopumps and hydo-turbines. The second part focuses on the theoretical modeling, experimental analysis, and practical control of cavitation-induced fluid-dynamic and rotordynamic instabilities of hydraulic turbomachinery, with special emphasis on cavitating...

  13. Strings, vortex rings, and modes of instability

    Directory of Open Access Journals (Sweden)

    Steven S. Gubser

    2015-03-01

    Full Text Available We treat string propagation and interaction in the presence of a background Neveu–Schwarz three-form field strength, suitable for describing vortex rings in a superfluid or low-viscosity normal fluid. A circular vortex ring exhibits instabilities which have been recognized for many years, but whose precise boundaries we determine for the first time analytically in the small core limit. Two circular vortices colliding head-on exhibit stronger instabilities which cause splitting into many small vortices at late times. We provide an approximate analytic treatment of these instabilities and show that the most unstable wavelength is parametrically larger than a dynamically generated length scale which in many hydrodynamic systems is close to the cutoff. We also summarize how the string construction we discuss can be derived from the Gross–Pitaevskii Lagrangian, and also how it compares to the action for giant gravitons.

  14. DNA instability, paternal irradiation and leukaemia in children around Sellafield

    International Nuclear Information System (INIS)

    Baverstock, K.F.

    1991-01-01

    The chemical instability of DNA under physiological conditions requires that cells have highly developed processes for repairing stochastic single-strand damage. It is proposed here that provided ionising-radiation-induced single-strand damage does not occur at a rate sufficient to perturb the dynamic steady state between degradation and repair, it can be regarded as 'irrelevant' to biological effect, leaving double-strand damage and DNA-protein crosslinks as 'relevant' damage to biological effect. At dose rates of ∼ 0.05 Gy/min low-LET radiation the rate of induced single-strand damage equals that of the spontaneous damage, and in this region a transition, with increasing dose-rate, from constant effect to increasing effect, will be expected. This is observed in studies of specific locus mutation by radiation in the male mouse. The application of this biophysical principle governing the influence of radiation dose-rate, to the association observed between paternal preconceptional dose to Sellafield workers and childhood leukaemia in their offspring, shows that the likelihood of a casual relationship is extremely remote. (author)

  15. Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice.

    Directory of Open Access Journals (Sweden)

    Rabindra N Bhattacharjee

    Full Text Available BACKGROUND: Telomeres are essential to maintain chromosomal stability. Cells derived from mice lacking telomerase RNA component (mTERC-/- mice display elevated telomere-mediated chromosome instability. Age-dependent telomere shortening and associated chromosome instability reduce the capacity to respond to cellular stress occurring during inflammation and cancer. Inflammation is one of the important risk factors in cancer progression. Controlled innate immune responses mediated by Toll-like receptors (TLR are required for host defense against infection. Our aim was to understand the role of chromosome/genome instability in the initiation and maintenance of inflammation. METHODOLOGY/PRINCIPAL FINDINGS: We examined the function of TLR4 in telomerase deficient mTERC-/- mice harbouring chromosome instability which did not develop any overt immunological disorder in pathogen-free condition or any form of cancers at this stage. Chromosome instability was measured in metaphase spreads prepared from wildtype (mTERC+/+, mTERC+/- and mTERC-/- mouse splenocytes. Peritoneal and/or bone marrow-derived macrophages were used to examine the responses of TLR4 by their ability to produce inflammatory mediators TNFalpha and IL6. Our results demonstrate that TLR4 is highly up-regulated in the immune cells derived from telomerase-null (mTERC-/- mice and lipopolysaccharide, a natural ligand for TLR4 stabilises NF-kappaB binding to its promoter by down-regulating ATF-3 in mTERC-/- macrophages. CONCLUSIONS/SIGNIFICANCE: Our findings implied that background chromosome instability in the cellular level stabilises the action of TLR4-induced NF-kappaB action and sensitises cells to produce excess pro-inflammatory mediators. Chromosome/genomic instability data raises optimism for controlling inflammation by non-toxic TLR antagonists among high-risk groups.

  16. Radiation-induced myelopathy

    Energy Technology Data Exchange (ETDEWEB)

    Gaenshirt, H [Heidelberg Univ. (F.R. Germany). Neurologische Klinik

    1975-10-01

    12 cases of radiation-induced myelopathy after /sup 60/Co teletherapy are reported on. Among these were 10 thoracal lesions, one cerviothoracal lesion, and one lesion of the medulla oblongata. In 9 cases, Hodgkin's disease had been the primary disease, tow patients had been irradiated because of suspected vertebral metastases of cancer of the breast, and one patient had suffered from a glomus tumour of the petrous bone. The spinal doses had exceeded the tolerance doses recommended in the relevant literature. There was no close correlation between the radiation dose and the course of the disease. The latency periods between the end of the radiotherapy and the onset of the neurological symptons varied from 6 to 16 mouths and were very constant in 7 cases with 6 to 9 months. The segmental height of the lesion corresponded to the level of irradiation. The presenting symptons of radiation-induced myelopathy are buruing dysaesthesias and Brown-Sequard's paralysis which may develop into transverse lesion of the cord with paraplegia still accompanied by dissociated perception disorders. The disease developed intermittently. Disturbances of the bladder function are frequent. The fluid is normal in most cases. Myelographic examinations were made in 8 cases. 3 cases developed into stationary cases exhibiting. Brown-Sequard syndrome, while 9 patients developed transverse lesion of the cord with paraplegia. 3 patients have died; antopsy findings are given for two of these. In the pathogenesis of radiation-induced myelopathy, the vascular factor is assumed to be of decisive importance.

  17. Progress in understanding turbulent mixing induced by Rayleigh-Taylor and Richtmyer-Meshkov instabilities

    International Nuclear Information System (INIS)

    Zhou Ye; Remington, B.A.; Robey, H.F.; Cook, A.W.; Glendinning, S.G.; Dimits, A.; Buckingham, A.C.; Zimmerman, G.B.; Burke, E.W.; Peyser, T.A.; Cabot, W.; Eliason, D.

    2003-01-01

    Turbulent hydrodynamic mixing induced by the Rayleigh-Taylor (RT) and Richtmyer-Meshkov (RM) instabilities occurs in settings as varied as exploding stars (supernovae), inertial confinement fusion (ICF) capsule implosions, and macroscopic flows in fluid dynamics facilities such as shock tubes. Turbulence theory and modeling have been applied to RT and RM induced flows and developed into a quantitative description of turbulence from the onset to the asymptotic end-state. The treatment, based on a combined approach of theory, direct numerical simulation (DNS), and experimental data analysis, has broad generality. Three areas of progress will be reported. First, a robust, easy to apply criteria will be reported for the mixing transition in a time-dependent flow. This allows an assessment of whether flows, be they from supernova explosions or ICF experiments, should be mixed down to the molecular scale or not. Second, through DNS, the structure, scaling, and spectral evolution of the RT instability induced flow will be inspected. Finally, using these new physical insights, a two-scale, dynamic mix model has been developed that can be applied to simulations of ICF experiments and astrophysics situations alike

  18. Microbunch Instability Theory and Simulations

    Energy Technology Data Exchange (ETDEWEB)

    Stupakov, G.

    2005-01-26

    Over the last years there have been several reports of quasiperiodic bursts of coherent synchrotron radiation (CSR) in electron rings in the microwave and far-infrared range. The observations were made on synchrotron radiation light sources which include the Synchrotron Ultraviolet Radiation Facility SURF II [1], the VUV ring at the National Synchrotron Light Source at BNL [2, 3], second generation light sources MAX-I [4], BESSY II [5], and ALS [6]. General features of those observations can be summarized as follows. Above a threshold current, there is a strongly increased radiation of the beam in the range of wavelengths shorter than the bunch length, {lambda} < {sigma}{sub 2}. At large currents, this radiation is observed as a sequence of random bursts. In the bursting regime, intensity of the radiation scales approximately as square of the number of particles in the bunch, indicating a coherent nature of the phenomenon. It is generally accepted that the source of this radiation is related to the microbunching of the beam arising from development of a microwave instability caused by the coherent synchrotron radiation of the beam. A relativistic electron beam moving in a circular orbit in free space can radiate coherently if the wavelength of the synchrotron radiation exceeds the length of the bunch. In accelerators coherent radiation of the bunch is usually suppressed by the shielding effect of the conducting walls of the vacuum chamber [7-9], which gives an exponential cutoff of wavelengths greater than a certain threshold. However, an initial density fluctuation with a characteristic length much shorter than the shielding threshold would radiate coherently. If the radiation reaction force is such that it results in the growth of the initial fluctuation one can expect an instability that leads to micro-bunching of the beam and an increased coherent radiation at short wavelengths. A possibility of CSR instability was pointed out in Refs. [10, 11].

  19. Mass-induced instability of SAdS black hole in Einstein-Ricci cubic gravity

    Science.gov (United States)

    Myung, Yun Soo

    2018-05-01

    We perform the stability analysis of Schwarzschild-AdS (SAdS) black hole in the Einstein-Ricci cubic gravity. It shows that the Ricci tensor perturbations exhibit unstable modes for small black holes. We call this the mass-induced instability of SAdS black hole because the instability of small black holes arises from the massiveness in the linearized Einstein-Ricci cubic gravity, but not a feature of higher-order derivative theory giving ghost states. Also, we point out that the correlated stability conjecture holds for the SAdS black hole by computing the Wald entropy of SAdS black hole in Einstein-Ricci cubic gravity.

  20. In Vitro Studies on Space Radiation-Induced Delayed Genetic Responses: Shielding Effects

    Science.gov (United States)

    Kadhim, Munira A.; Green, Lora M.; Gridley, Daila S.; Murray, Deborah K.; Tran, Da Thao; Andres, Melba; Pocock, Debbie; Macdonald, Denise; Goodhead, Dudley T.; Moyers, Michael F.

    2003-01-01

    Understanding the radiation risks involved in spaceflight is of considerable importance, especially with the long-term occupation of ISS and the planned crewed exploration missions. Several independent causes may contribute to the overall risk to astronauts exposed to the complex space environment, such as exposure to GCR as well as SPES. Protons and high-Z energetic particles comprise the GCR spectrum and may exert considerable biological effects even at low fluence. There are also considerable uncertainties associated with secondary particle effects (e.g. HZE fragments, neutrons etc.). The interaction of protons and high-LET particles with biological materials at all levels of biological organization needs to be investigated fully in order to establish a scientific basis for risk assessment. The results of these types of investigation will foster the development of appropriately directed countermeasures. In this study, we compared the biological responses to proton irradiation presented to the target cells as a monoenergetic beam of particles of complex composition delivered to cells outside or inside a tissue phantom head placed in the United States EVA space suit helmet. Measurements of chromosome aberrations, apoptosis, and the induction of key proteins were made in bone marrow from CBA/CaJ and C57BL/6 mice at early and late times post exposure to radiation at 0, 0.5, 1 and 2 Gy while inside or outside of the helmet. The data showed that proton irradiation induced transmissible chromosomal/genomic instability in haematopoietic stem cells in both strains of mice under both irradiation conditions and especially at low doses. Although differences were noted between the mouse strains in the degree and kinetics of transforming growth factor-beta 1 and tumor necrosis factor-alpha secretion, there were no significant differences observed in the level of the induced instability under either radiation condition, or for both strains of mice. Consequently, when

  1. Progress in indirect and direct-drive planar experiments on hydrodynamic instabilities at the ablation front

    Energy Technology Data Exchange (ETDEWEB)

    Casner, A., E-mail: alexis.casner@cea.fr; Masse, L.; Huser, G.; Galmiche, D.; Liberatore, S.; Riazuelo, G. [CEA, DAM, DIF, F-91297 Arpajon (France); Delorme, B. [CEA, DAM, DIF, F-91297 Arpajon (France); CELIA, University of Bordeaux-CNRS-CEA, F-33400 Talence (France); Martinez, D.; Remington, B.; Smalyuk, V. A. [Lawrence Livermore National Laboratory, Livermore, California 94550 (United States); Igumenshchev, I.; Michel, D. T.; Froula, D.; Seka, W.; Goncharov, V. N. [Laboratory of Laser Energetics, Rochester, New York 14623-1299 (United States); Olazabal-Loumé, M.; Nicolaï, Ph.; Breil, J.; Tikhonchuk, V. T. [CELIA, University of Bordeaux-CNRS-CEA, F-33400 Talence (France); Fujioka, S. [Institute of Laser Engineering, Osaka University, Suita, Osaka 565 (Japan); and others

    2014-12-15

    Understanding and mitigating hydrodynamic instabilities and the fuel mix are the key elements for achieving ignition in Inertial Confinement Fusion. Cryogenic indirect-drive implosions on the National Ignition Facility have evidenced that the ablative Rayleigh-Taylor Instability (RTI) is a driver of the hot spot mix. This motivates the switch to a more flexible higher adiabat implosion design [O. A. Hurricane et al., Phys. Plasmas 21, 056313 (2014)]. The shell instability is also the main candidate for performance degradation in low-adiabat direct drive cryogenic implosions [Goncharov et al., Phys. Plasmas 21, 056315 (2014)]. This paper reviews recent results acquired in planar experiments performed on the OMEGA laser facility and devoted to the modeling and mitigation of hydrodynamic instabilities at the ablation front. In application to the indirect-drive scheme, we describe results obtained with a specific ablator composition such as the laminated ablator or a graded-dopant emulator. In application to the direct drive scheme, we discuss experiments devoted to the study of laser imprinted perturbations with special phase plates. The simulations of the Richtmyer-Meshkov phase reversal during the shock transit phase are challenging, and of crucial interest because this phase sets the seed of the RTI growth. Recent works were dedicated to increasing the accuracy of measurements of the phase inversion. We conclude by presenting a novel imprint mitigation mechanism based on the use of underdense foams. The foams induce laser smoothing by parametric instabilities thus reducing the laser imprint on the CH foil.

  2. Oxidized low density lipoprotein induced caspase-1 mediated pyroptotic cell death in macrophages: implication in lesion instability?

    Directory of Open Access Journals (Sweden)

    Jing Lin

    Full Text Available BACKGROUND: Macrophage death in advanced lesion has been confirmed to play an important role in plaque instability. However, the mechanism underlying lesion macrophage death still remains largely unknown. METHODS AND RESULTS: Immunohistochemistry showed that caspase-1 activated in advanced lesion and co-located with macrophages and TUNEL positive reaction. In in-vitro experiments showed that ox-LDL induced caspase-1 activation and this activation was required for ox-LDL induced macrophages lysis, IL-1β and IL-18 production as well as DNA fragmentation. Mechanism experiments showed that CD36 and NLRP3/caspase-1/pathway involved in ox-LDL induced macrophage pyroptosis. CONCLUSION: Our study here identified a novel cell death, pyroptosis in ox-LDL induced human macrophage, which may be implicated in lesion macrophages death and play an important role in lesion instability.

  3. Instability of a double layer and initiation of a photoelectric gas discharge by UV radiation

    International Nuclear Information System (INIS)

    Meshalkin, E.A.

    1991-01-01

    At the present time there is no theory or systematic experiments for the conversion of the energy of vacuum uv radiation into current energy in connection with the photoelectric effect in gases. The aim in this work was to study the process by which an SCL is established and to obtain a gas discharge associated with photoemission (a photoelectric gas discharge), similar to the gas discharge in thermal-emission converters, in order to transform optical energy into electrical current. The development of a space-charge layer (SCL) is studied when a metallic target in air or nitrogen at a pressure in the range 10 -3 -10 torr is subjected to UV radiation. A laser plasma was used as the source of the UV radiation, modulated in intensity at a frequency of 75 MHz. It was found that after a period of development in the course of which the potential difference across the SCL can reach 185 V, it drops abruptly. This effect is due to an instability of the SCL which arises because the pressure of the electron gas in the background plasma exceeds the confining pressure of the electric field which penetrates from SCL into the plasma. A photoelectric arc discharge was observed in which the energy of the UV radiation was converted into current energy with an efficiency ∼ 1%. The current was found to be 3.1 A and the power in the load was 10W. Because of the threshold for the occurrence of the instability in the SCL, the potential drop across the SCL could be completely modulated at a frequency of 75 MHz. The amplitude of the HF current reached 0.3 A

  4. Radiation-induced polymerization and radiation effect on polymers

    International Nuclear Information System (INIS)

    Seguchi, Tadao

    1977-12-01

    The processes of radiation-induced polymerization of monomers and also radiation effects on polymers have been studied by instrumental analyses of electron spin resonance (ESR), nuclear magnetic resonance (NMR) and electron microscopy. In radiation-induced polymerization, graft-copolymerization and absorbed state polymerization were taken up. For graft-copolymerization, monomers such as methylmethacrylate and butadiene were made to react with irradiated polyethylene, and behaviors of the initiating radicals and propagating radicals were followed under the reaction by ESR. For absorbed state polymerization, acrylonitrile/zeolite and methylmethacrylate/zeolite were chosen. Absorbed monomers were irradiated at 77 0 K and polymerized at room temperature. Active species and the concentrations were measured by ESR and the yields of polymer were observed by NMR. In radiation effect on polymers, polyvinylfluoride, polyvinylidenfluoride and polytetrafluoroethylene were taken up. Active species trapped in the polymer matrixes were identified and decay and reactivity of the species were also studied. On the basis of information from the electron microscopy and x-ray analysis, radiation effects on these polymers are described. In polytetrafluoroethylene produced by radiation polymerization, the relation between morphology and polymerization conditions and also the process of crystallization during polymerization were studied. (auth.)

  5. Study on radiation-inducible genes

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Yong; Kim, Dong Ho; Joe, Min Ho; Park, Hae Jun; Song, Hyu Npa

    2012-01-15

    Radiation-inducible genes of E. coli, which is a model strain for bacterial study, and Salmonella, which is a typical strain for pathogenic bacteria were compared through omic analysis. Heat shock response genes and prophage genes were induced by radiation in Salmonella, not in E. coli. Among prophage genes tested, STM2628 showed the highest activation by radiation, and approximately 1 kb promoter region was turned out to be necessary for radiation response. To screen an artificial promoter showing activation by 2 Gy, the high-throughput screening method using fluorescent MUG substrate was established. The use of bacteria as anticancer agents has attracted interest. In this study, we tried to develop tumor targeting bacteria in which the radiation-inducible promoter activate a transgene encoding a cytotoxic protein. To do this, a tumor-targeting hfq Salmonella mutant strain was constructed, and we found that its virulence decreased. For outward secretion of anticancer protein produced inside bacteria, the signal peptide of SspH1 was determined and the signal peptide was proven to be able to secrete an anticancer protein. Tumor xenograft mouse model was secured, which can be used for efficiency evaluation of bacterial tumor therapy.

  6. Study on radiation-inducible genes

    International Nuclear Information System (INIS)

    Lim, Sang Yong; Kim, Dong Ho; Joe, Min Ho; Park, Hae Jun; Song, Hyu Npa

    2012-01-01

    Radiation-inducible genes of E. coli, which is a model strain for bacterial study, and Salmonella, which is a typical strain for pathogenic bacteria were compared through omic analysis. Heat shock response genes and prophage genes were induced by radiation in Salmonella, not in E. coli. Among prophage genes tested, STM2628 showed the highest activation by radiation, and approximately 1 kb promoter region was turned out to be necessary for radiation response. To screen an artificial promoter showing activation by 2 Gy, the high-throughput screening method using fluorescent MUG substrate was established. The use of bacteria as anticancer agents has attracted interest. In this study, we tried to develop tumor targeting bacteria in which the radiation-inducible promoter activate a transgene encoding a cytotoxic protein. To do this, a tumor-targeting hfq Salmonella mutant strain was constructed, and we found that its virulence decreased. For outward secretion of anticancer protein produced inside bacteria, the signal peptide of SspH1 was determined and the signal peptide was proven to be able to secrete an anticancer protein. Tumor xenograft mouse model was secured, which can be used for efficiency evaluation of bacterial tumor therapy

  7. Radiation-induced cancers in man

    International Nuclear Information System (INIS)

    Hirose, Fumio

    1978-01-01

    Radiation-induced cancers in man were divided into three groups, a group in which cancers occurred after atomic bomb exposure, a group in which cancers occurred in radiologists and other medical specialists, and a group in which cancers occurred after exposure to diagnostic radiation, and they were summarized. In atomic bomb survivors leukemia, thyroid cancer, salivary gland cancer, lung cancer, and breast cancer occurred so frequently. In addition to them, mortality ratios by malignant lymphoma, stomach cancer, esophageal cancer, and by cancer of urinary tract were increased. The incidence of leukemia was decreased in those who treated radiation owing to the development of the protection of occupational exposure, and the incidence of radiation-induced cancers was decreased in patients owing to the improvement of therapy. However, a new problem has arisen as to the occurrence of cancers after medical exposure, such as various histological types of cancers after the treatment of skin diseases on the head, and breast cancer after the treatment of pneumothorax. Dose-to-effect relation, hereditary factors, effect of age, immunological influences and endocrine actions were also studied in each radiation-induced cancer. (Ichikawa, K.)

  8. Radiation-induced cancers in man

    Energy Technology Data Exchange (ETDEWEB)

    Hirose, F [Hiroshima Univ. (Japan). Research Inst. for Nuclear Medicine and Biology

    1978-07-01

    Radiation-induced cancers in man were divided into three groups, a group in which cancers occurred after atomic bomb exposure, a group in which cancers occurred in radiologists and other medical specialists, and a group in which cancers occurred after exposure to diagnostic radiation, and they were summarized. In atomic bomb survivors leukemia, thyroid cancer, salivary gland cancer, lung cancer, and breast cancer occurred so frequently. In addition to them, mortality ratios by malignant lymphoma, stomach cancer, esophageal cancer, and by cancer of urinary tract were increased. The incidence of leukemia was decreased in those who treated radiation owing to the development of the protection of occupational exposure, and the incidence of radiation-induced cancers was decreased in patients owing to the improvement of therapy. However, a new problem has arisen as to the occurrence of cancers after medical exposure, such as various histological types of cancers after the treatment of skin diseases on the head, and breast cancer after the treatment of pneumothorax. Dose-to-effect relation, hereditary factors, effect of age, immunological influences and endocrine actions were also studied in each radiation-induced cancer.

  9. Narrow linewidth pulsed optical parametric oscillator

    Indian Academy of Sciences (India)

    Tunable narrow linewidth radiation by optical parametric oscillation has many applications, particularly in spectroscopic investigation. In this paper, different techniques such as injection seeding, use of spectral selecting element like grating, grating and etalon in combination, grazing angle of incidence, entangled cavity ...

  10. Delayed repair of radiation induced clustered DNA damage: Friend or foe?

    International Nuclear Information System (INIS)

    Eccles, Laura J.; O'Neill, Peter; Lomax, Martine E.

    2011-01-01

    A signature of ionizing radiation exposure is the induction of DNA clustered damaged sites, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. Clustered damage is made up of double strand breaks (DSB) with associated base lesions or abasic (AP) sites, and non-DSB clusters comprised of base lesions, AP sites and single strand breaks. This review will concentrate on the experimental findings of the processing of non-DSB clustered damaged sites. It has been shown that non-DSB clustered damaged sites compromise the base excision repair pathway leading to the lifetime extension of the lesions within the cluster, compared to isolated lesions, thus the likelihood that the lesions persist to replication and induce mutation is increased. In addition certain non-DSB clustered damaged sites are processed within the cell to form additional DSB. The use of E. coli to demonstrate that clustering of DNA lesions is the major cause of the detrimental consequences of ionizing radiation is also discussed. The delayed repair of non-DSB clustered damaged sites in humans can be seen as a 'friend', leading to cell killing in tumour cells or as a 'foe', resulting in the formation of mutations and genetic instability in normal tissue.

  11. Radiation-induced brain injury: A review

    Directory of Open Access Journals (Sweden)

    Michael eRobbins

    2012-07-01

    Full Text Available Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive long enough (> 6 months to experience radiation-induced brain injury. Prior to 1970, the human brain was thought to be highly radioresistant; the acute CNS syndrome occurs after single doses > 30 Gy; white matter necrosis occurs at fractionated doses > 60 Gy. Although white matter necrosis is uncommon with modern techniques, functional deficits, including progressive impairments in memory, attention, and executive function have become important, because they have profound effects on quality of life. Preclinical studies have provided valuable insights into the pathogenesis of radiation-induced cognitive impairment. Given its central role in memory and neurogenesis, the majority of these studies have focused on the hippocampus. Irradiating pediatric and young adult rodent brains leads to several hippocampal changes including neuroinflammation and a marked reduction in neurogenesis. These data have been interpreted to suggest that shielding the hippocampus will prevent clinical radiation-induced cognitive impairment. However, this interpretation may be overly simplistic. Studies using older rodents, that more closely match the adult human brain tumor population, indicate that, unlike pediatric and young adult rats, older rats fail to show a radiation-induced decrease in neurogenesis or a loss of mature neurons. Nevertheless, older rats still exhibit cognitive impairment. This occurs in the absence of demyelination and/or white matter necrosis similar to what is observed clinically, suggesting that more subtle molecular, cellular and/or microanatomic modifications are involved in this radiation-induced brain injury. Given that radiation-induced cognitive impairment likely reflects damage to both hippocampal- and non-hippocampal-dependent domains, there is a critical need to investigate the microanatomic and functional effects of radiation in various brain

  12. Global optimization of silicon nanowires for efficient parametric processes

    DEFF Research Database (Denmark)

    Vukovic, Dragana; Xu, Jing; Mørk, Jesper

    2013-01-01

    We present a global optimization of silicon nanowires for parametric single-pump mixing. For the first time, the effect of surface roughness-induced loss is included in the analysis, significantly influencing the optimum waveguide dimensions.......We present a global optimization of silicon nanowires for parametric single-pump mixing. For the first time, the effect of surface roughness-induced loss is included in the analysis, significantly influencing the optimum waveguide dimensions....

  13. Ionizing radiation induced malignancies in man

    International Nuclear Information System (INIS)

    Dutrillaux, B.

    1997-01-01

    Using data on gene and chromosome alterations in human cancers, it is proposed that most radiation induced cancers are a consequence of recessive mutations of tumor suppressor genes. This explains the long delay between radiation exposure and the cancer onset. As a consequence, radiation induced cancers belong to groups of tumors where no specific translocations (forming or activating oncogenes) but multiple unbalanced chromosome rearrangements (deletions unmasking recessive mutations) exist. This explains why osteosarcomas, malignant fibrous histiocytoma, chondrosarcomas are frequently induced, but not liposarcoma, Ewing sarcomas and rhabdomyosarcomas, among others. A single exception confirms this rule: papillary thyroid cancer, frequently induced in exposed children, in which structural rearrangements frequently form a RET/PTC3 fusion gene. This fusion gene is the results of the inversion of a short segment of chromosome 10, and it is assumed that such rearrangement (small para-centric inversion) can easily occur after exposure to radiations, at contrast with translocations between to genes belonging to different chromosomes. (author)

  14. Three cases of radiation-induced cancer in oral regions

    International Nuclear Information System (INIS)

    Kawamura, Hiroshi; Shinoki, Kunihiko; Endo, Yoshitaka; Fujita, Yasushi; Hayashi, Susumu

    1985-01-01

    Three cases of radiation-induced cancer in the oral regions were reported with relation to radiation therapy. One was the general radiation-induced cancer following radiotherapy for the hemangioma. The other two cases, which belonged in the B-1 group of Sakai and his coworker's diagnostic criteria for radiation-induced cancer, were those occurring after radiotherapy for the malignant tumors. Due to the relatively high dosage exposure by the patient in the radiotherapy it is necessary to look out the latency of the radiation-induced cancer. After radiotherapy, careful and periodical observation is important for immediate treatment in an early stage for the radiation-induced cancer to have a favorable prognosis. In addition careful observation of the changes after radiotherapy helps in discovering the precancerous lesions from the therapy. For the radiation-induced cancer, surgical treatment would be the best, however, radiation therapy is also effective in certain cases. (author)

  15. A simulation study of electron-cloud instability and beam-induced multipacting in the LHC

    International Nuclear Information System (INIS)

    Zimmermann, F.

    1997-02-01

    In the LHC beam pipe, photoemission and secondary emission give rise to a quasi-stationary electron cloud, which is established after a few bunch passages. The response of this electron cloud to a transversely displaced bunch resembles a short-range wakefield and can cause a fast instability. In addition, beam-induced multipacting of the electrons may lead to an enhanced gas desorption and an associated pressure increase. In this paper the authors report preliminary simulation results of the electron-cloud build-up both in a dipole magnet and in a straight section of the LHC at top energy. The effective wakefield created by the electron cloud translates into an instability rise time of about 25 ms horizontally and 130 ms vertically. This rise time is not much larger than that of the resistive-wall instability at injection energy

  16. The nature and principles of the radiation-induced cancerogenesis

    International Nuclear Information System (INIS)

    Lips'ka, A.YI.; Serkyiz, Ya.Yi.

    2004-01-01

    The paper represents the analysis of the authors and literary data concerning the nature and principles of the radiation-induced neoplasms. The mechanisms of the radiation-induced cancerogenesis development are not clear understood. The experimental data altogether do not allow developing the mathematical model of the radiation-induced cancerogenesis at the molecular level. This model has to take into account all necessary indices including radiation factor and the state of the organism. The general principles of the radiation-induced cancerogenesis have been formulated in the present review. It is possible to use these principles in order to predict and calculate the risks of the radiation-induced neoplasms

  17. Flow-Induced Instabilities in Pump-Turbines in China

    Directory of Open Access Journals (Sweden)

    Zhigang Zuo

    2017-08-01

    Full Text Available The stability of pump-turbines is of great importance to the operation of pumped storage power (PSP stations. Both hydraulic instabilities and operational instabilities have been reported in PSP stations in China. In order to provide a reference to the engineers and scientists working on pump-turbines, this paper summarizes the hydraulic instabilities and performance characteristics that promote the operational instabilities encountered in pump-turbine operations in China. Definitions, analytical methods, numerical and experimental studies, and main results are clarified. Precautions and countermeasures are also provided based on a literature review. The gaps between present studies and the need for engineering practice are pointed out.

  18. Instabilities constraint and relativistic mean field parametrization

    International Nuclear Information System (INIS)

    Sulaksono, A.; Kasmudin; Buervenich, T.J.; Reinhard, P.-G.; Maruhn, J.A.

    2011-01-01

    Two parameter sets (Set 1 and Set 2) of the standard relativistic mean field (RMF) model plus additional vector isoscalar nonlinear term, which are constrained by a set of criteria 20 determined by symmetric nuclear matter stabilities at high densities due to longitudinal and transversal particle–hole excitation modes are investigated. In the latter parameter set, δ meson and isoscalar as well as isovector tensor contributions are included. The effects in selected finite nuclei and nuclear matter properties predicted by both parameter sets are systematically studied and compared with the ones predicted by well-known RMF parameter sets. The vector isoscalar nonlinear term addition and instability constraints have reasonably good effects in the high-density properties of the isoscalar sector of nuclear matter and certain finite nuclei properties. However, even though the δ meson and isovector tensor are included, the incompatibility with the constraints from some experimental data in certain nuclear properties at saturation point and the excessive stiffness of the isovector nuclear matter equation of state at high densities as well as the incorrect isotonic trend in binding the energies of finite nuclei are still encountered. It is shown that the problem may be remedied if we introduce additional nonlinear terms not only in the isovector but also in the isoscalar vectors. (author)

  19. Radiation-induced linking reactions in polyethylene

    International Nuclear Information System (INIS)

    Zoepfl, F.J.

    1983-01-01

    Three types of measurements are reported relating to chemical reactions in polyethylene induced by ionizing radiation: 1) viscometric and low-angle laser light scattering measurements to determine the effect of a radical scavenger on the yield of links; 2) calorimetric measurements to determine the effect of radiation-induced linking on the melting behavior of polyethylene; and 3) high-resolution solution carbon 13 nuclear magnetic resonance (NMR) spectrometry measurements to determine the nature of the links and the method of their formation. The NMR results present the first direct detection of radiation-induced long-chain branching (Y links) in polyethylene, and place an apparent upper limit on the yield of H-shaped crosslinks that are formed when polyethylene is irradiated to low absorbed doses. The effect of radiation-induced linking on the melting behavior of polyethylene was examined using differential scanning calorimetry (DSC). It was found that radiation-induced links do not change the heat of fusion of polythylene crystals, but decrease the melt entropy and increase the fold surface free energy per unit area of the crystals. The carbon 13 NMR results demonstrate that long-chain branches (Y links) are formed much more frequently than H-shaped crosslinks at low absorbed doses. The Y links are produced by reactions of alkyl free radicals with terminal vinyl groups in polyethylene

  20. Epigenetic effects of ionizing radiation

    International Nuclear Information System (INIS)

    EI-Naggar, A.M.

    2007-01-01

    Data generated during the last three decades provide evidence of Epigenetic Effects that ave-induced by ionizing radiation, particularly those of high LET values, and low level dose exposures. Epigenesist is defined as the stepwise process by which genetic information, as modified by environmental influences, is translated into the substance and behavior of cells, tissues, organism.The epigenetic effects cited in the literature are essentially classified into fine types depending on the type and nature of the effect induced.The most accepted postulation, for the occurrence of these epigenetic effects, is a radiation induced bio electric disturbances in the environment of the non-irradiated cellular volume. This will trigger signals that will induce effects in the unirradiated cells.The epigenetic effects referenced in the literature up to date are five types; namely, Genomic Instability, Bystander. Effects, Clastogenic Plasma Factors,, Abscopal Effects, and Tran generational Effects.The demonstration of Epigenetic Effects associated with exposure to ionizing radiation indicates the need to re- examine the concept of radiation dose and target size. Also an improved understanding of qualifiring and quantifying radiation risk estimates may be attained. Also, a more logical means to understand the underlying mechanisms of radiation induced carcinogenic transformation of cells

  1. Parametric instability in the Watt governor with periodic loading

    International Nuclear Information System (INIS)

    Bhattacharjee, Shayak; Kumar, Krishna

    2014-01-01

    In this work we examine a potential source of instability in the Watt governor, which can occur when the governor is subjected to periodic variation of the load torque. Floquet analysis is used to obtain the condition for existence of the unstable solutions, and results are obtained which supplement the usual Maxwell–Vyshnegradskii conditions for governor stability. Pedagogically, this paper is relevant for senior undergraduate students. It presents a detailed yet simple exposition of classical Floquet theory, a subject often ignored in undergraduate education even though the related concept of Bloch's theorem is popular in quantum mechanics courses. At the same time, it touches on certain practical engineering applications of physical concepts, with its discussion on mechanical governors. (paper)

  2. Transmission of persistent ionizing radiation-induced foci through cell division in human primary cells

    Energy Technology Data Exchange (ETDEWEB)

    Vaurijoux, Aurelie, E-mail: aurelie.vaurijoux@irsn.fr [Institut de Radioprotection et de Sureté Nucléaire (IRSN), Laboratoire de Dosimétrie Biologique, BP 17, 92262 Fontenay aux roses cedex (France); Voisin, Pascale; Freneau, Amelie [Institut de Radioprotection et de Sureté Nucléaire (IRSN), Laboratoire de Dosimétrie Biologique, BP 17, 92262 Fontenay aux roses cedex (France); Barquinero, Joan Francesc [Universitat Autònoma de Barcelona, Faculty of Biosciences, 08193 Cerdanyola del Vallès (Spain); Gruel, Gaetan [Institut de Radioprotection et de Sureté Nucléaire (IRSN), Laboratoire de Dosimétrie Biologique, BP 17, 92262 Fontenay aux roses cedex (France)

    2017-03-15

    Highlights: • Persistent IRIF do not permanently block cell proliferation. • Persistent IRIF are transmitted in part and sometimes asymmetrically to daughter cells. • IRIF differ in their nature before and after the first cell division. - Abstract: Unrepaired DNA double-strand breaks (DSBs) induced by ionizing radiation are associated with lethal effects and genomic instability. After the initial breaks and chromatin destabilization, a set of post-translational modifications of histones occurs, including phosphorylation of serine 139 of histone H2AX (γH2AX), which leads to the formation of ionizing radiation-induced foci (IRIF). DSB repair results in the disappearance of most IRIF within hours after exposure, although some remain 24 h after irradiation. Their relation to unrepaired DSBs is generally accepted but still controversial. This study evaluates the frequency and kinetics of persistent IRIF and analyzes their impact on cell proliferation. We observed persistent IRIF up to 7 days postirradiation, and more than 70% of cells exposed to 5 Gy had at least one of these persistent IRIF 24 h after exposure. Moreover we demonstrated that persistent IRIF did not block cell proliferation definitively. The frequency of IRIF was lower in daughter cells, due to asymmetric distribution of IRIF between some of them. We report a positive association between the presence of IRIF and the likelihood of DNA missegregation. Hence, the structure formed after the passage of a persistent IRI focus across the S and G2 phases may impede the correct segregation of the affected chromosome's sister chromatids. The ensuing abnormal resolution of anaphase might therefore cause the nature of IRIF in daughter-cell nuclei to differ before and after the first cell division. The resulting atypical chromosomal assembly may be lethal or result in a gene dosage imbalance and possibly enhanced genomic instability, in particular in the daughter cells.

  3. Transmission of persistent ionizing radiation-induced foci through cell division in human primary cells

    International Nuclear Information System (INIS)

    Vaurijoux, Aurelie; Voisin, Pascale; Freneau, Amelie; Barquinero, Joan Francesc; Gruel, Gaetan

    2017-01-01

    Highlights: • Persistent IRIF do not permanently block cell proliferation. • Persistent IRIF are transmitted in part and sometimes asymmetrically to daughter cells. • IRIF differ in their nature before and after the first cell division. - Abstract: Unrepaired DNA double-strand breaks (DSBs) induced by ionizing radiation are associated with lethal effects and genomic instability. After the initial breaks and chromatin destabilization, a set of post-translational modifications of histones occurs, including phosphorylation of serine 139 of histone H2AX (γH2AX), which leads to the formation of ionizing radiation-induced foci (IRIF). DSB repair results in the disappearance of most IRIF within hours after exposure, although some remain 24 h after irradiation. Their relation to unrepaired DSBs is generally accepted but still controversial. This study evaluates the frequency and kinetics of persistent IRIF and analyzes their impact on cell proliferation. We observed persistent IRIF up to 7 days postirradiation, and more than 70% of cells exposed to 5 Gy had at least one of these persistent IRIF 24 h after exposure. Moreover we demonstrated that persistent IRIF did not block cell proliferation definitively. The frequency of IRIF was lower in daughter cells, due to asymmetric distribution of IRIF between some of them. We report a positive association between the presence of IRIF and the likelihood of DNA missegregation. Hence, the structure formed after the passage of a persistent IRI focus across the S and G2 phases may impede the correct segregation of the affected chromosome's sister chromatids. The ensuing abnormal resolution of anaphase might therefore cause the nature of IRIF in daughter-cell nuclei to differ before and after the first cell division. The resulting atypical chromosomal assembly may be lethal or result in a gene dosage imbalance and possibly enhanced genomic instability, in particular in the daughter cells.

  4. Non-targeted effects of radiation: applications for radiation protection and contribution to LNT discussion

    International Nuclear Information System (INIS)

    Belyakov, O.V.; Folkard, M.; Prise, K.M.; Michael, B.D.; Mothersill, C.

    2002-01-01

    According to the target theory of radiation induced effects (Lea, 1946), which forms a central core of radiation biology, DNA damage occurs during or very shortly after irradiation of the nuclei in targeted cells and the potential for biological consequences can be expressed within one or two cell generations. A range of evidence has now emerged that challenges the classical effects resulting from targeted damage to DNA. These effects have also been termed non-(DNA)-targeted (Ward, 1999) and include radiation-induced bystander effects (Iyer and Lehnert, 2000a), genomic instability (Wright, 2000), adaptive response (Wolff, 1998), low dose hyper-radiosensitivity (HRS) (Joiner, et al., 2001), delayed reproductive death (Seymour, et al., 1986) and induction of genes by radiation (Hickman, et al., 1994). An essential feature of non-targeted effects is that they do not require a direct nuclear exposure by irradiation to be expressed and they are particularly significant at low doses. This new evidence suggests a new paradigm for radiation biology that challenges the universality of target theory. In this paper we will concentrate on the radiation-induced bystander effects because of its particular importance for radiation protection

  5. Parametric and Non-Parametric System Modelling

    DEFF Research Database (Denmark)

    Nielsen, Henrik Aalborg

    1999-01-01

    the focus is on combinations of parametric and non-parametric methods of regression. This combination can be in terms of additive models where e.g. one or more non-parametric term is added to a linear regression model. It can also be in terms of conditional parametric models where the coefficients...... considered. It is shown that adaptive estimation in conditional parametric models can be performed by combining the well known methods of local polynomial regression and recursive least squares with exponential forgetting. The approach used for estimation in conditional parametric models also highlights how...... networks is included. In this paper, neural networks are used for predicting the electricity production of a wind farm. The results are compared with results obtained using an adaptively estimated ARX-model. Finally, two papers on stochastic differential equations are included. In the first paper, among...

  6. Proceedings of the international conference on emerging frontiers and challenges in radiation biology: abstracts

    International Nuclear Information System (INIS)

    Purohit, R.K.; Chakrawarti, Aruna; Agarwal, Manisha; Arora, Anil

    2012-01-01

    This abstract volume includes abstracts related to six technical sessions of the conference viz., Radiation induced genomic instability and bystander effects, Radiation dosimetry and dose limits, Radiation protection and nuclear technology application, Molecular diagnosis and targeted therapy for cancer, cancer care and chemoradiotherapy, health hazards of radiation and protection. Papers relevant to INIS are indexed separately

  7. Experimental study of the Richtmyer-Meshkov instability induced by a Mach 3 shock wave

    International Nuclear Information System (INIS)

    BP Puranik; JG Oakley; MH Anderson; R Bonaazza

    2003-01-01

    OAK-B135 An experimental investigation of a shock-induced interfacial instability (Richtmyer-Meshkov instability) is undertaken in an effort to study temporal evolution of interfacial perturbations in the late stages of development. The experiments are performed in a vertical shock tube with a square cross-section. A membraneless interface is prepared by retracting a sinusoidally shaped metal plate initially separating carbon dioxide from air, with both gases initially at atmospheric pressure. With carbon dioxide above the plate, the Rayleigh-Taylor instability commences as the plate is retracted and the amplitude of the initial sinusoidal perturbation imposed on the interface begins to grow. The interface is accelerated by a strong shock wave (M=3.08) while its shape is still sinusoidal and before the Kelvin-Helmhotz instability distorts it into the well known mushroom-like structures; its initial amplitude to wavelength ratio is large enough that the interface evolution enters its nonlinear stage very shortly after shock acceleration. The pre-shock evolution of the interface due to the Rayleigh-Taylor instability and the post-shock evolution of the interface due to the Richtmyer-Meshkov instability are visualized using planar Mie scattering. The pre-shock evolution of the interface is carried out in an independent set of experiments. The initial conditions for the Richtmyer-Meshkov experiment are determined from the pre-shock Rayleigh-Taylor growth. One image of the post-shock interface is obtained per experiment and image sequences, showing the post-shock evolution of the interface, are constructed from several experiments. The growth rate of the perturbation amplitude is measured and compared with two recent analytical models of the Richtmyer-Meshkov instability

  8. Radiation-induced brain injury: A review

    Energy Technology Data Exchange (ETDEWEB)

    Greene-Schloesser, Dana; Robbins, Mike E.; Peiffer, Ann M.; Shaw, Edward G. [Department of Radiation Oncology, Wake Forest School of Medicine,, Winston-Salem, NC (United States); Brain Tumor Center of Excellence, Wake Forest School of Medicine,, Winston-Salem, NC (United States); Wheeler, Kenneth T. [Brain Tumor Center of Excellence, Wake Forest School of Medicine,, Winston-Salem, NC (United States); Department of Radiology, Wake Forest School of Medicine,, Winston-Salem, NC (United States); Chan, Michael D., E-mail: mrobbins@wakehealth.edu [Department of Radiation Oncology, Wake Forest School of Medicine,, Winston-Salem, NC (United States); Brain Tumor Center of Excellence, Wake Forest School of Medicine,, Winston-Salem, NC (United States)

    2012-07-19

    Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive long enough (>6 months) to experience radiation-induced brain injury. Prior to 1970, the human brain was thought to be highly radioresistant; the acute CNS syndrome occurs after single doses >30 Gy; white matter necrosis occurs at fractionated doses >60 Gy. Although white matter necrosis is uncommon with modern techniques, functional deficits, including progressive impairments in memory, attention, and executive function have become important, because they have profound effects on quality of life. Preclinical studies have provided valuable insights into the pathogenesis of radiation-induced cognitive impairment. Given its central role in memory and neurogenesis, the majority of these studies have focused on the hippocampus. Irradiating pediatric and young adult rodent brains leads to several hippocampal changes including neuroinflammation and a marked reduction in neurogenesis. These data have been interpreted to suggest that shielding the hippocampus will prevent clinical radiation-induced cognitive impairment. However, this interpretation may be overly simplistic. Studies using older rodents, that more closely match the adult human brain tumor population, indicate that, unlike pediatric and young adult rats, older rats fail to show a radiation-induced decrease in neurogenesis or a loss of mature neurons. Nevertheless, older rats still exhibit cognitive impairment. This occurs in the absence of demyelination and/or white matter necrosis similar to what is observed clinically, suggesting that more subtle molecular, cellular and/or microanatomic modifications are involved in this radiation-induced brain injury. Given that radiation-induced cognitive impairment likely reflects damage to both hippocampal- and non-hippocampal-dependent domains, there is a critical need to investigate the microanatomic and functional effects of radiation in various brain regions as well as their

  9. Radiation-induced brain injury: A review

    International Nuclear Information System (INIS)

    Greene-Schloesser, Dana; Robbins, Mike E.; Peiffer, Ann M.; Shaw, Edward G.; Wheeler, Kenneth T.; Chan, Michael D.

    2012-01-01

    Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive long enough (>6 months) to experience radiation-induced brain injury. Prior to 1970, the human brain was thought to be highly radioresistant; the acute CNS syndrome occurs after single doses >30 Gy; white matter necrosis occurs at fractionated doses >60 Gy. Although white matter necrosis is uncommon with modern techniques, functional deficits, including progressive impairments in memory, attention, and executive function have become important, because they have profound effects on quality of life. Preclinical studies have provided valuable insights into the pathogenesis of radiation-induced cognitive impairment. Given its central role in memory and neurogenesis, the majority of these studies have focused on the hippocampus. Irradiating pediatric and young adult rodent brains leads to several hippocampal changes including neuroinflammation and a marked reduction in neurogenesis. These data have been interpreted to suggest that shielding the hippocampus will prevent clinical radiation-induced cognitive impairment. However, this interpretation may be overly simplistic. Studies using older rodents, that more closely match the adult human brain tumor population, indicate that, unlike pediatric and young adult rats, older rats fail to show a radiation-induced decrease in neurogenesis or a loss of mature neurons. Nevertheless, older rats still exhibit cognitive impairment. This occurs in the absence of demyelination and/or white matter necrosis similar to what is observed clinically, suggesting that more subtle molecular, cellular and/or microanatomic modifications are involved in this radiation-induced brain injury. Given that radiation-induced cognitive impairment likely reflects damage to both hippocampal- and non-hippocampal-dependent domains, there is a critical need to investigate the microanatomic and functional effects of radiation in various brain regions as well as their

  10. Delayed Radiation-Induced Vasculitic Leukoencephalopathy

    Energy Technology Data Exchange (ETDEWEB)

    Rauch, Philipp J. [Departments of Pathology and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut (United States); Faculty of Medicine, University of Heidelberg, Heidelberg (Germany); Park, Henry S. [Departments of Pathology and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut (United States); Knisely, Jonathan P.S. [Department of Radiation Medicine, North Shore University Hospital, Manhasset, New York (United States); Chiang, Veronica L. [Departments of Pathology and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut (United States); Vortmeyer, Alexander O., E-mail: alexander.vortmeyer@yale.edu [Departments of Pathology and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut (United States)

    2012-05-01

    Purpose: Recently, single-fraction, high-dosed focused radiation therapy such as that administered by Gamma Knife radiosurgery has been used increasingly for the treatment of metastatic brain cancer. Radiation therapy to the brain can cause delayed leukoencephalopathy, which carries its own significant morbidity and mortality. While radiosurgery-induced leukoencephalopathy is known to be clinically different from that following fractionated radiation, pathological differences are not well characterized. In this study, we aimed to integrate novel radiographic and histopathologic observations to gain a conceptual understanding of radiosurgery-induced leukoencephalopathy. Methods and Materials: We examined resected tissues of 10 patients treated at Yale New Haven Hospital between January 1, 2009, and June 30, 2010, for brain metastases that had been previously treated with Gamma Knife radiosurgery, who subsequently required surgical management of a symptomatic regrowing lesion. None of the patients showed pathological evidence of tumor recurrence. Clinical and magnetic resonance imaging data for each of the 10 patients were then studied retrospectively. Results: We provide evidence to show that radiosurgery-induced leukoencephalopathy may present as an advancing process that extends beyond the original high-dose radiation field. Neuropathologic examination of the resected tissue revealed traditionally known leukoencephalopathic changes including demyelination, coagulation necrosis, and vascular sclerosis. Unexpectedly, small and medium-sized vessels revealed transmural T-cell infiltration indicative of active vasculitis. Conclusions: We propose that the presence of a vasculitic component in association with radiation-induced leukoencephalopathy may facilitate the progressive nature of the condition. It may also explain the resemblance of delayed leukoencephalopathy with recurring tumor on virtually all imaging modalities used for posttreatment follow-up.

  11. Visible-light-induced instability in amorphous metal-oxide based TFTs for transparent electronics

    Directory of Open Access Journals (Sweden)

    Tae-Jun Ha

    2014-10-01

    Full Text Available We investigate the origin of visible-light-induced instability in amorphous metal-oxide based thin film transistors (oxide-TFTs for transparent electronics by exploring the shift in threshold voltage (Vth. A large hysteresis window in amorphous indium-gallium-zinc-oxide (a-IGZO TFTs possessing large optical band-gap (≈3 eV was observed in a visible-light illuminated condition whereas no hysteresis window was shown in a dark measuring condition. We also report the instability caused by photo irradiation and prolonged gate bias stress in oxide-TFTs. Larger Vth shift was observed after photo-induced stress combined with a negative gate bias than the sum of that after only illumination stress and only negative gate bias stress. Such results can be explained by trapped charges at the interface of semiconductor/dielectric and/or in the gate dielectric which play a role in a screen effect on the electric field applied by gate voltage, for which we propose that the localized-states-assisted transitions by visible-light absorption can be responsible.

  12. Visible-light-induced instability in amorphous metal-oxide based TFTs for transparent electronics

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Tae-Jun [Department of Electronic Materials Engineering, Kwangwoon University, Seoul 139-701 (Korea, Republic of)

    2014-10-15

    We investigate the origin of visible-light-induced instability in amorphous metal-oxide based thin film transistors (oxide-TFTs) for transparent electronics by exploring the shift in threshold voltage (V{sub th}). A large hysteresis window in amorphous indium-gallium-zinc-oxide (a-IGZO) TFTs possessing large optical band-gap (≈3 eV) was observed in a visible-light illuminated condition whereas no hysteresis window was shown in a dark measuring condition. We also report the instability caused by photo irradiation and prolonged gate bias stress in oxide-TFTs. Larger V{sub th} shift was observed after photo-induced stress combined with a negative gate bias than the sum of that after only illumination stress and only negative gate bias stress. Such results can be explained by trapped charges at the interface of semiconductor/dielectric and/or in the gate dielectric which play a role in a screen effect on the electric field applied by gate voltage, for which we propose that the localized-states-assisted transitions by visible-light absorption can be responsible.

  13. Radiation from a Relativistic Electron Beam in a Molecular Medium due to Parametric Pumping by a Strong Electromagnetic Wave,

    Science.gov (United States)

    1981-02-01

    UNIVERSITY OF MARYLAND DEPARTMENT OF PHYSICS 4WJD ASTRONOMY COLLG PAM A 2 3i 81 4 30) 235. RADIATION FROM A .ELATIVISTIC_§LECTRON BEAM IN AZOLECULAR...A MOLECULAR MEDIUM DUE TO PARAMETRIC PUMPING BY A STRONG ELECTROMAGNETIC WAVE L. Stenflo Department of Plasma Physics Umel University S-90187 Umel...GUteborg, Sweden and Laboratory for Plasma and Fusion Energy Studies University of Maryland College Park, Maryland 20742 Physics Publication Number 81

  14. Beclin 1 and UVRAG confer protection from radiation-induced DNA damage and maintain centrosome stability in colorectal cancer cells.

    Directory of Open Access Journals (Sweden)

    Jae Myung Park

    Full Text Available Beclin 1 interacts with UV-irradiation-resistance-associated gene (UVRAG to form core complexes that induce autophagy. While cells with defective autophagy are prone to genomic instability that contributes to tumorigenesis, it is unknown whether Beclin1 or UVRAG can regulate the DNA damage/repair response to cancer treatment in established tumor cells. We found that siRNA knockdown of Beclin 1 or UVRAG can increase radiation-induced DNA double strand breaks (DSBs, shown by pATM and γH2Ax, and promote colorectal cancer cell death. Furthermore, knockdown of Beclin 1, UVRAG or ATG5 increased the percentage of irradiated cells with nuclear foci expressing 53BP1, a marker of nonhomologous end joining but not RAD51 (homologous recombination, compared to control siRNA. Beclin 1 siRNA was shown to attenuate UVRAG expression. Cells with a UVRAG deletion mutant defective in Beclin 1 binding showed increased radiation-induced DSBs and cell death compared to cells with ectopic wild-type UVRAG. Knockdown of Beclin 1 or UVRAG, but not ATG5, resulted in a significant increase in centrosome number (γ-tubulin staining in irradiated cells compared to control siRNA. Taken together, these data indicate that Beclin 1 and UVRAG confer protection against radiation-induced DNA DSBs and may maintain centrosome stability in established tumor cells.

  15. DMA mitigates ionizing radiation induced damage in Balb/c mice through Akt/NFκB/PTEN pathway

    International Nuclear Information System (INIS)

    Tiwari, Vinod; Ranjan, Atul; Tandon, Vibha

    2014-01-01

    Ionizing radiation is associated with massive apoptosis in tumor as well as in radiosensitive organs. DMA, (5-(4-methylpiperazin-1-yl)-2-(2'-(3,4-dimethoxy-phenyl)-5'-benzimidazolyl) a cytoprotective radiomodulator, work in dual mode of action as free radical quencher and modifier of genomic instability caused by radiation. We observed 34% radioprotection with 50 mg/Kg bw intravenous dose of DMA in Balb/c mice at 8 Gy. DMA treatment before irradiation restored the normal crypts and villi architecture in Balb/c mice. The villi height was restored equivalent to control group in DMA treated animals, whereas, it was degenerated in irradiated animals. IR-induced apoptosis was reduced in spleen in presence of DMA as a result of preservation of splenic lymphocytes from radiation. This clearly exhibits the radioprotective ability of DMA to mitigate radiation induced tissue damage. IR-induced S phase check point was overcome by DMA. DMA promoted activation and phosphorylation of GSK3β through the activation of Akt in Balb/c mice. There was reduction in PTEN level in DMA pretreated mice where as it was upregulated in irradiated mice. Relative enhanced kinase activity of Akt was observed in DMA treated Balb/c mice and irradiated A549, MRC5 cell lines. There was no significant radioprotection in DMA treated Akt siRNA transfected cells in comparison to only Akt siRNA transfected cells with increasing dose of radiation. Akt activation was found in a dose-dependent manner by DMA through Luciferase reporter assay. We observed that DMA treated HEK cells transfected with control siRNA, resulted in less early apoptotic cells within 24h, but radiation (5 Gy) treated cells showed 20% early apoptotic cells within 3 h which were reduced to 12% at 3 h, 9% at 6 h and 8% at 24 h in DMA+radiation treated cells determined by Annexin V binding assay. Further molecular mRNA expression analysis of key regulatory genes unveil that DMA inhibited p21 and augmented Akt and Gadd45 in

  16. Parametric decay instability near the upper hybrid resonance in magnetically confined fusion plasmas

    DEFF Research Database (Denmark)

    Hansen, Søren Kjer; Nielsen, Stefan Kragh; Salewski, Mirko

    2017-01-01

    In this paper we investigate parametric decay of an electromagnetic pump wave into two electrostatic daughter waves, particularly an X-mode pump wave decaying into a warm upper hybrid wave (a limit of an electron Bernstein wave) and a warm lower hybrid wave. We describe the general theory...

  17. An Experimental Study of Roughness-Induced Instabilities in a Supersonic Boundary Layer

    Science.gov (United States)

    Kegerise, Michael A.; King, Rudolph A.; Choudhari, Meelan; Li, Fei; Norris, Andrew

    2014-01-01

    Progress on an experimental study of laminar-to-turbulent transition induced by an isolated roughness element in a supersonic laminar boundary layer is reported in this paper. Here, the primary focus is on the effects of roughness planform shape on the instability and transition characteristics. Four different roughness planform shapes were considered (a diamond, a circle, a right triangle, and a 45 degree fence) and the height and width of each one was held fixed so that a consistent frontal area was presented to the oncoming boundary layer. The nominal roughness Reynolds number was 462 and the ratio of the roughness height to the boundary layer thickness was 0.48. Detailed flow- field surveys in the wake of each geometry were performed via hot-wire anemometry. High- and low-speed streaks were observed in the wake of each roughness geometry, and the modified mean flow associated with these streak structures was found to support a single dominant convective instability mode. For the symmetric planform shapes - the diamond and circular planforms - the instability characteristics (mode shapes, growth rates, and frequencies) were found to be similar. For the asymmetric planform shapes - the right-triangle and 45 degree fence planforms - the mode shapes were asymmetrically distributed about the roughness-wake centerline. The instability growth rates for the asymmetric planforms were lower than those for the symmetric planforms and therefore, transition onset was delayed relative to the symmetric planforms.

  18. The amount of DNA damage needed to activate the radiation-induced G2 checkpoint varies between single cells

    International Nuclear Information System (INIS)

    Tkacz-Stachowska, Kinga; Lund-Andersen, Christin; Velissarou, Angeliki; Myklebust, June H.; Stokke, Trond; Syljuåsen, Randi G.

    2011-01-01

    Background and purpose: The radiation-induced G2 checkpoint helps facilitate DNA repair before cell division. However, recent work has revealed that human cells often escape the G2 checkpoint with unrepaired DNA breaks. The purpose was to explore whether G2 checkpoint activation occurs according to a threshold level of DNA damage. Materials and methods: G2 checkpoint activation was assayed at 75–90 min and 24–48 h after X-ray irradiation of BJ diploid fibroblasts and U2OS osteosarcoma cells. Multiparameter flow cytometry with pacific blue barcoding, and flow cytometry-based sorting of phospho-H3 positive cells to microscope slides, were used to examine the DNA damage marker γ-H2AX in individual mitotic cells that had escaped the G2 checkpoint. Results: For all radiation doses and times tested, the number of γ-H2AX foci varied between individual mitotic cells. At 75 min the median levels of γ-H2AX in mitotic cells increased with higher radiation doses. At 24–48 h, following a prolonged G2 checkpoint, cells were more resistant to checkpoint re-activation by a second dose of radiation. Conclusion: Our results suggest that different amounts of DNA damage are needed to activate the G2 checkpoint in individual cells. Such single cell variation in checkpoint activation may potentially contribute to radiation-induced genomic instability.

  19. Electron-cloud instabilities and beam-induced multipacting in the LHC and in the VLHC

    International Nuclear Information System (INIS)

    Zimmermann, F.

    1997-10-01

    In the beam pipe of the Large Hadron Collider (LHC), photoemission and secondary emission give rise to a quasi-stationary electron cloud, which is established after a few buncn passages. The response of this electron cloud to a transversely displaced bunch resembles a short-range wakefield and can cause a fast instability. In additoin, beam-induced multipacting of the electrons may lead to an enhanced gas desorption and an associated pressure increase. In this paper the authors report preliminary simulation results of the electron-cloud build-up both in a dipole magnet and in a straight section of the LHC at top energy. The effective wakefield created by the electron cloud translates into an instability rise time of about 40 ms horizontally and 500 ms vertically. This rise time is not much larger than that of the resistive-wall instability at injection energy. Similar simulation studies show that the instability rise time for the proposed Very Large Hadron Collider (VLHC) is about 3--4 s in both trasnverse planes. The smaller growth rate in the VLHC, as compared with the LHC, is primarily due to the much lower bunch population

  20. Onset of Absolute Instability Induced by Viscous Dissipation in the Poiseuille-Darcy-Benard Convection of a Newtonian Fluid

    International Nuclear Information System (INIS)

    Brandão, P V; Alves, L S de B; Barletta, A

    2014-01-01

    The present paper investigates the transition from convective to absolute instability induced by viscous dissipation. As far as the authors are aware, this is the first time such a study is reported in the literature. Its framework is provided by the Poiseuille-Darcy-Benard convection of a Newtonian fluid. We found the same behaviour observed in the absence of viscous dissipation whenever the Gebhart number is smaller than Ge < 0.95, which is the stabilising effect of the cross flow. When 0.95 < Ge < 4.31, weak cross flows still stabilise the onset of absolute instability but stronger cross flows destabilise it. For a stronger viscous dissipation, i.e. Ge > 4.31, the cross flow always destabilises this onset. The latter two conditions create a scenario where viscous dissipation is capable of inducing a transition to absolute instability in the absence of wall heating, i.e. with a zero Rayleigh number

  1. Two-dimensional simulations of magnetically-driven instabilities

    International Nuclear Information System (INIS)

    Peterson, D.; Bowers, R.; Greene, A.E.; Brownell, J.

    1986-01-01

    A two-dimensional Eulerian MHD code is used to study the evolution of magnetically-driven instabilities in cylindrical geometry. The code incorporates an equation of state, resistivity, and radiative cooling model appropriate for an aluminum plasma. The simulations explore the effects of initial perturbations, electrical resistivity, and radiative cooling on the growth and saturation of the instabilities. Comparisons are made between the 2-D simulations, previous 1-D simulations, and results from the Pioneer experiments of the Los Alamos foil implosion program

  2. Genomic instability after targeted irradiation of human lymphocytes: Evidence for inter-individual differences under bystander conditions

    International Nuclear Information System (INIS)

    Kadhim, Munira A.; Lee, Ryonfa; Moore, Stephen R.; Macdonald, Denise A.; Chapman, Kim L.; Patel, Gaurang; Prise, Kevin M.

    2010-01-01

    Environmental 222 radon exposure is a human health concern, and many studies demonstrate that very low doses of high LET α-particle irradiation initiate deleterious genetic consequences in both irradiated and non-irradiated bystander cells. One consequence, radiation-induced genomic instability (RIGI), is a hallmark of tumorigenesis and is often assessed by measuring delayed chromosomal aberrations. We utilised a technique that facilitates transient immobilization of primary lymphocytes for targeted microbeam irradiation and have reported that environmentally relevant doses, e.g. a single 3 He 2+ particle traversal to a single cell, are sufficient to induce RIGI. Herein we sought to determine differences in radiation response in lymphocytes isolated from five healthy male donors. Primary lymphocytes were irradiated with a single particle per cell nucleus. We found evidence for inter-individual variation in radiation response (RIGI, measured as delayed chromosome aberrations). Although this was not highly significant, it was possibly masked by high levels of intra-individual variation. While there are many studies showing a link between genetic predisposition and RIGI, there are few studies linking genetic background with bystander effects in normal human lymphocytes. In an attempt to investigate inter-individual variation in the induction of bystander effects, primary lymphocytes were irradiated with a single particle under conditions where fractions of the population were traversed. We showed a marked genotype-dependent bystander response in one donor after exposure to 15% of the population. The findings may also be regarded as a radiation-induced genotype-dependent bystander effect triggering an instability phenotype.

  3. Genomic instability after targeted irradiation of human lymphocytes: Evidence for inter-individual differences under bystander conditions

    Energy Technology Data Exchange (ETDEWEB)

    Kadhim, Munira A., E-mail: mkadhim@brookes.ac.uk [School of Life Sciences, Oxford Brookes University, Oxford OX3 0BP (United Kingdom); Lee, Ryonfa [Biophysics, GSI Helmholtzzentrum fuer Schwerionenforschung GmbH, Planckstrasse 1, D-64291 Darmstadt (Germany); Moore, Stephen R.; Macdonald, Denise A. [Radiation and Genome Stability Unit, Medical Research Council, Harwell, Oxfordshire OX11 0RD (United Kingdom); Chapman, Kim L. [School of Life Sciences, Oxford Brookes University, Oxford OX3 0BP (United Kingdom); Patel, Gaurang; Prise, Kevin M. [Centre for Cancer Research and Cell Biology, Queen' s University Belfast, Belfast BT9 7BL (United Kingdom)

    2010-06-01

    Environmental {sup 222}radon exposure is a human health concern, and many studies demonstrate that very low doses of high LET {alpha}-particle irradiation initiate deleterious genetic consequences in both irradiated and non-irradiated bystander cells. One consequence, radiation-induced genomic instability (RIGI), is a hallmark of tumorigenesis and is often assessed by measuring delayed chromosomal aberrations. We utilised a technique that facilitates transient immobilization of primary lymphocytes for targeted microbeam irradiation and have reported that environmentally relevant doses, e.g. a single {sup 3}He{sup 2+} particle traversal to a single cell, are sufficient to induce RIGI. Herein we sought to determine differences in radiation response in lymphocytes isolated from five healthy male donors. Primary lymphocytes were irradiated with a single particle per cell nucleus. We found evidence for inter-individual variation in radiation response (RIGI, measured as delayed chromosome aberrations). Although this was not highly significant, it was possibly masked by high levels of intra-individual variation. While there are many studies showing a link between genetic predisposition and RIGI, there are few studies linking genetic background with bystander effects in normal human lymphocytes. In an attempt to investigate inter-individual variation in the induction of bystander effects, primary lymphocytes were irradiated with a single particle under conditions where fractions of the population were traversed. We showed a marked genotype-dependent bystander response in one donor after exposure to 15% of the population. The findings may also be regarded as a radiation-induced genotype-dependent bystander effect triggering an instability phenotype.

  4. Role of neurotensin in radiation-induced hypothermia in rats

    International Nuclear Information System (INIS)

    Kandasamy, S.B.; Hunt, W.A.; Harris, A.H.

    1991-01-01

    The role of neurotensin in radiation-induced hypothermia was examined. Intracerebroventricular (ICV) administration of neurotensin produced dose-dependent hypothermia. Histamine appears to mediate neurotensin-induced hypothermia because the mast cell stabilizer disodium cromoglycate and antihistamines blocked the hypothermic effects of neurotensin. An ICV pretreatment with neurotensin antibody attenuated neurotensin-induced hypothermia, but did not attenuate radiation-induced hypothermia, suggesting that radiation-induced hypothermia was not mediated by neurotensin

  5. Non-linear hydrodynamic instability and turbulence in eccentric astrophysical discs with vertical structure

    Science.gov (United States)

    Wienkers, A. F.; Ogilvie, G. I.

    2018-04-01

    Non-linear evolution of the parametric instability of inertial waves inherent to eccentric discs is studied by way of a new local numerical model. Mode coupling of tidal deformation with the disc eccentricity is known to produce exponentially growing eccentricities at certain mean-motion resonances. However, the details of an efficient saturation mechanism balancing this growth still are not fully understood. This paper develops a local numerical model for an eccentric quasi-axisymmetric shearing box which generalises the often-used cartesian shearing box model. The numerical method is an overall second order well-balanced finite volume method which maintains the stratified and oscillatory steady-state solution by construction. This implementation is employed to study the non-linear outcome of the parametric instability in eccentric discs with vertical structure. Stratification is found to constrain the perturbation energy near the mid-plane and localise the effective region of inertial wave breaking that sources turbulence. A saturated marginally sonic turbulent state results from the non-linear breaking of inertial waves and is subsequently unstable to large-scale axisymmetric zonal flow structures. This resulting limit-cycle behaviour reduces access to the eccentric energy source and prevents substantial transport of angular momentum radially through the disc. Still, the saturation of this parametric instability of inertial waves is shown to damp eccentricity on a time-scale of a thousand orbital periods. It may thus be a promising mechanism for intermittently regaining balance with the exponential growth of eccentricity from the eccentric Lindblad resonances and may also help explain the occurrence of "bursty" dynamics such as the superhump phenomenon.

  6. Universal model of bias-stress-induced instability in inkjet-printed carbon nanotube networks field-effect transistors

    Science.gov (United States)

    Jung, Haesun; Choi, Sungju; Jang, Jun Tae; Yoon, Jinsu; Lee, Juhee; Lee, Yongwoo; Rhee, Jihyun; Ahn, Geumho; Yu, Hye Ri; Kim, Dong Myong; Choi, Sung-Jin; Kim, Dae Hwan

    2018-02-01

    We propose a universal model for bias-stress (BS)-induced instability in the inkjet-printed carbon nanotube (CNT) networks used in field-effect transistors (FETs). By combining two experimental methods, i.e., a comparison between air and vacuum BS tests and interface trap extraction, BS instability is explained regardless of either the BS polarity or ambient condition, using a single platform constituted by four key factors: OH- adsorption/desorption followed by a change in carrier concentration, electron concentration in CNT channel corroborated with H2O/O2 molecules in ambient, charge trapping/detrapping, and interface trap generation. Under negative BS (NBS), the negative threshold voltage shift (ΔVT) is dominated by OH- desorption, which is followed by hole trapping in the interface and/or gate insulator. Under positive BS (PBS), the positive ΔVT is dominated by OH- adsorption, which is followed by electron trapping in the interface and/or gate insulator. This instability is compensated by interface trap extraction; PBS instability is slightly more complicated than NBS instability. Furthermore, our model is verified using device simulation, which gives insights on how much each mechanism contributes to BS instability. Our result is potentially useful for the design of highly stable CNT-based flexible circuits in the Internet of Things wearable healthcare era.

  7. Delayed repair of radiation induced clustered DNA damage: Friend or foe?

    Science.gov (United States)

    Eccles, Laura J.; O’Neill, Peter; Lomax, Martine E.

    2011-01-01

    A signature of ionizing radiation exposure is the induction of DNA clustered damaged sites, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. Clustered damage is made up of double strand breaks (DSB) with associated base lesions or abasic (AP) sites, and non-DSB clusters comprised of base lesions, AP sites and single strand breaks. This review will concentrate on the experimental findings of the processing of non-DSB clustered damaged sites. It has been shown that non-DSB clustered damaged sites compromise the base excision repair pathway leading to the lifetime extension of the lesions within the cluster, compared to isolated lesions, thus the likelihood that the lesions persist to replication and induce mutation is increased. In addition certain non-DSB clustered damaged sites are processed within the cell to form additional DSB. The use of E. coli to demonstrate that clustering of DNA lesions is the major cause of the detrimental consequences of ionizing radiation is also discussed. The delayed repair of non-DSB clustered damaged sites in humans can be seen as a “friend”, leading to cell killing in tumour cells or as a “foe”, resulting in the formation of mutations and genetic instability in normal tissue. PMID:21130102

  8. Relationship between radiation induced activation of DNA repair genes and radiation induced apoptosis in human cell line A431

    International Nuclear Information System (INIS)

    Bom, Hee Seung; Min, Jung Jun; Kim, Kyung Keun; Choi, Keun Hee

    2000-01-01

    The purpose of this study was to evaluate the relationship between radiation-induced acivation of DNA repair genes and radiation induced apoptosis in A431 cell line. Five and 25 Gys of gamma radiation were given to A431 cells by a Cs-137 cell irradiator. Apoptosis was evaluated by flow cytometry using annexin V-fluorescein isothiocyanate and propidium iodide staining. The expression of DNA repair genes was evaluated by both Northern and Western blot analyses. The number of apoptotic cells increased with the increased radiation dose. It increased most significantly at 12 hours after irradiation. Expression of p53, p21, and ℎRAD50 reached the highest level at 12 hours after 5 Gy irradiation. In response to 25 Gy irradiation, ℎRAD50 and p21 were expressed maximally at 12 hours, but p53 and GADD45 genes showed the highest expression level after 12 hours. Induction of apoptosis and DNA repair by ionizing radiation were closely correlated. The peak time of inducing apoptosis and DNA repair was 12 hours in this study model. ℎRAD50, a recently discovered DNA repair gene, was also associated with radiation-induced apoptosis.=20

  9. Study on radiation-inducible genes

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Sang Yong; Kim, Dong Ho; Joe, Min Ho; Song, Hyu Npa

    2012-01-15

    Transcription of previously identified radiation-inducible genes, uscA and cyoA, was examined responding to radiation. The putative promoter regions of both genes were cloned into pRS415 vector containing lacZ, and the core promoter region necessary for radiation response were determined through promoter deletion method. To investigate the role of uscA, which is assumed to be small RNA related with radiation response, a deletion mutant strain of uscA was constructed. However, uscA deletion did not affect bacterial survival against radiation exposure. The use of bacteria as anticancer agents has attracted interest. In this study, we tried to develop tumor targeting bacteria in which the radiation-inducible promoter activate a transgene encoding a cytotoxic protein. For outward secretion of anticancer protein produced inside bacteria, the N-terminal 140 amino acid of SspH1 was found to function as a secretion signal peptide. To create an attenuated tumor-targeting bacteria, Salmonella ptsI mutant strain was constructed, and we found that its virulence decreased. Finally, the tumor-targeting ability of ptsI mutant was verified by the use of in-vivo imaging analysis.

  10. Study on radiation-inducible genes

    International Nuclear Information System (INIS)

    Lim, Sang Yong; Kim, Dong Ho; Joe, Min Ho; Song, Hyu Npa

    2012-01-01

    Transcription of previously identified radiation-inducible genes, uscA and cyoA, was examined responding to radiation. The putative promoter regions of both genes were cloned into pRS415 vector containing lacZ, and the core promoter region necessary for radiation response were determined through promoter deletion method. To investigate the role of uscA, which is assumed to be small RNA related with radiation response, a deletion mutant strain of uscA was constructed. However, uscA deletion did not affect bacterial survival against radiation exposure. The use of bacteria as anticancer agents has attracted interest. In this study, we tried to develop tumor targeting bacteria in which the radiation-inducible promoter activate a transgene encoding a cytotoxic protein. For outward secretion of anticancer protein produced inside bacteria, the N-terminal 140 amino acid of SspH1 was found to function as a secretion signal peptide. To create an attenuated tumor-targeting bacteria, Salmonella ptsI mutant strain was constructed, and we found that its virulence decreased. Finally, the tumor-targeting ability of ptsI mutant was verified by the use of in-vivo imaging analysis

  11. Beam instability Workshop - plenary sessions

    International Nuclear Information System (INIS)

    2001-01-01

    The purpose of this workshop was to provide a review of the mechanisms of limiting beam instabilities, their cures, including feedback, and beam measurement for synchrotron radiation light sources. 12 plenary sessions took place whose titles are: 1) challenging brilliance and lifetime issues with increasing currents; 2) limiting instabilities in multibunch; 3) experience from high currents in B factories; 4) longitudinal dynamics in high intensity/bunch; 5) Transverse instabilities for high intensity/bunch; 6) working group introduction from ESRF experience; 7) impedance modelling: simulations, minimization; 8) report on the broadband impedance measurements and modelling workshop; 9) feedback systems for synchrotron light sources; 10) beam instabilities diagnostics; 11) harmonic cavities: the pros and cons; and 12) experimental study of fast beam-ion instabilities at PLS. This document gathers the 12 articles that were presented during these sessions

  12. Beam instability Workshop - plenary sessions

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The purpose of this workshop was to provide a review of the mechanisms of limiting beam instabilities, their cures, including feedback, and beam measurement for synchrotron radiation light sources. 12 plenary sessions took place whose titles are: 1) challenging brilliance and lifetime issues with increasing currents; 2) limiting instabilities in multibunch; 3) experience from high currents in B factories; 4) longitudinal dynamics in high intensity/bunch; 5) Transverse instabilities for high intensity/bunch; 6) working group introduction from ESRF experience; 7) impedance modelling: simulations, minimization; 8) report on the broadband impedance measurements and modelling workshop; 9) feedback systems for synchrotron light sources; 10) beam instabilities diagnostics; 11) harmonic cavities: the pros and cons; and 12) experimental study of fast beam-ion instabilities at PLS. This document gathers the 12 articles that were presented during these sessions.

  13. Heritability of Radiation Response in Lung Cancer Families

    Directory of Open Access Journals (Sweden)

    H.-Erich Wichmann

    2012-03-01

    Full Text Available Radiation sensitivity is assumed to be a cancer susceptibility factor due to impaired DNA damage signalling and repair. Relevant genetic factors may also determine the observed familial aggregation of early onset lung cancer. We investigated the heritability of radiation sensitivity in families of 177 Caucasian cases of early onset lung cancer. In total 798 individuals were characterized for their radiation-induced DNA damage response. DNA damage analysis was performed by alkaline comet assay before and after in vitro irradiation of isolated lymphocytes. The cells were exposed to a dose of 4 Gy and allowed to repair induced DNA-damage up to 60 minutes. The primary outcome parameter Olive Tail Moment was the basis for heritability estimates. Heritability was highest for basal damage (without irradiation 70% (95%-CI: 51%–88% and initial damage (directly after irradiation 65% (95%-CI: 47%–83% and decreased to 20%–48% for the residual damage after different repair times. Hence our study supports the hypothesis that genomic instability represented by the basal DNA damage as well as radiation induced and repaired damage is highly heritable. Genes influencing genome instability and DNA repair are therefore of major interest for the etiology of lung cancer in the young. The comet assay represents a proper tool to investigate heritability of the radiation sensitive phenotype. Our results are in good agreement with other mutagen sensitivity assays.

  14. Role of endothelium in radiation-induced normal tissue damages

    International Nuclear Information System (INIS)

    Milliat, F.

    2007-05-01

    More than half of cancers are treated with radiation therapy alone or in combination with surgery and/or chemotherapy. The goal of radiation therapy is to deliver enough ionising radiation to destroy cancer cells without exceeding the level that the surrounding healthy cells can tolerate. Unfortunately, radiation-induced normal tissue injury is still a dose limiting factor in the treatment of cancer with radiotherapy. The knowledge of normal tissue radiobiology is needed to determine molecular mechanisms involved in normal tissue pathogenic pathways in order to identify therapeutic targets and develop strategies to prevent and /or reduce side effects of radiation therapy. The endothelium is known to play a critical role in radiation-induced injury. Our work shows that endothelial cells promote vascular smooth muscle cell proliferation, migration and fibro-genic phenotype after irradiation. Moreover, we demonstrate for the first time the importance of PAI-1 in radiation-induced normal tissue damage suggesting that PAI-1 may represent a molecular target to limit injury following radiotherapy. We describe a new role for the TGF-b/Smad pathway in the pathogenesis of radiation-induced damages. TGF-b/Smad pathway is involved in the fibro-genic phenotype of VSMC induced by irradiated EC as well as in the radiation-induced PAI-1 expression in endothelial cells. (author)

  15. Instabilities in passive dispersion oscillating fiber ring cavities

    Science.gov (United States)

    Copie, François; Conforti, Matteo; Kudlinski, Alexandre; Mussot, Arnaud; Biancalana, Fabio; Trillo, Stefano

    2017-05-01

    We investigate theoretically and experimentally the development of instabilities in passive ring cavities with stepwise longitudinal variation of the dispersion. We derive an extended version of the Lugiato-Lefever equation that permits to model dispersion oscillating cavities and we demonstrate that this equation is valid well beyond the mean field approximation. We review the theory of Turing (modulational) and Faraday (parametric) instability in inhomogeneous fiber cavities. We report the experimental demonstration of the generation of stable Turing and Faraday temporal patterns in the same device, which can be controlled by changing the detuning and/or the input power. Moreover, we experimentally record the round-trip-to-round-trip dynamics of the spectrum, which shows that Turing and Faraday instabilities not only differ by their characteristic frequency but also by their dynamical behavior. Contribution to the Topical Issue: "Theory and Applications of the Lugiato-Lefever Equation", edited by Yanne K. Chembo, Damia Gomila, Mustapha Tlidi, Curtis R. Menyuk.

  16. Gravitational instabilities of the cosmic neutrino background with non-zero lepton number

    Directory of Open Access Journals (Sweden)

    Neil D. Barrie

    2017-09-01

    Full Text Available We argue that a cosmic neutrino background that carries non-zero lepton charge develops gravitational instabilities. Fundamentally, these instabilities are related to the mixed gravity-lepton number anomaly. We have explicitly computed the gravitational Chern–Simons term which is generated quantum-mechanically in the effective action in the presence of a lepton number asymmetric neutrino background. The induced Chern–Simons term has a twofold effect: (i gravitational waves propagating in such a neutrino background exhibit birefringent behaviour leading to an enhancement/suppression of the gravitational wave amplitudes depending on the polarisation, where the magnitude of this effect is related to the size of the lepton asymmetry; (ii Negative energy graviton modes are induced in the high frequency regime, which leads to very fast vacuum decay producing, e.g., positive energy photons and negative energy gravitons. From the constraint on the present radiation energy density, we obtain an interesting bound on the lepton asymmetry of the universe.

  17. Measurements of the parametric decay of CO2 laser radiation into plasma waves at quarter critical density using ruby laser Thomson scattering

    International Nuclear Information System (INIS)

    Schuss, J.J.; Chu, T.K.; Johnson, L.C.

    1977-11-01

    We report the results of small-angle ruby laser Thomson scattering measurements of the parametric excitation of plasma waves by CO 2 laser radiation at quarter-critical density in a laser-heated gas target plasma. From supplementary data obtained from interferometry and large-angle ruby laser scattering we infer that the threshold conditions for a convective decay are satisfied

  18. Temperature-gradient instability induced by conducting end walls

    International Nuclear Information System (INIS)

    Berk, H.L.; Ryutov, D.D.; Tsidulko, Yu.A.

    1990-04-01

    A new rapidly growing electron temperature gradient instability is found for a plasma in contact with a conducting wall. The linear instability analysis is presented and speculations are given for its nonlinear consequences. This instability illustrates that conducting walls can produce effects that are detrimental to plasma confinement. This mode should be of importance in open-ended systems including astrophysical plasmas, mirror machines and at the edge of tokamaks where field lines are open and are connected to limiters or divertors. 16 refs., 2 figs

  19. Parametric instability of spinning elastic rings excited by fluctuating space-fixed stiffnesses

    Science.gov (United States)

    Liu, Chunguang; Cooley, Christopher G.; Parker, Robert G.

    2017-07-01

    This study investigates the vibration of rotating elastic rings that are dynamically excited by an arbitrary number of space-fixed discrete stiffnesses with periodically fluctuating stiffnesses. The rotating, elastic ring is modeled using thin-ring theory with radial and tangential deformations. Primary and combination instability regions are determined in closed-form using the method of multiple scales. The ratio of peak-to-peak fluctuation to average discrete stiffness is used as the perturbation parameter, so the resulting perturbation analysis is not limited to small mean values of discrete stiffnesses. The natural frequencies and vibration modes are determined by discretizing the governing equations using Galerkin's method. Results are demonstrated for compliant gear applications. The perturbation results are validated by direct numerical integration of the equations of motion and Floquet theory. The bandwidths of the instability regions correlate with the fractional strain energy stored in the discrete stiffnesses. For rings with multiple discrete stiffnesses, the phase differences between them can eliminate large amplitude response under certain conditions.

  20. Quantitative analysis of negative bias illumination stress-induced instability mechanisms in amorphous InGaZnO thin-film transistors

    International Nuclear Information System (INIS)

    Kim, Yong Sik; Bae, Min Kyung; Kong, Dong Sik; Jung, Hyun Kwang; Kim, Jae Hyeong; Kim, Woo Joon; Hur, In Seok; Kim, Dong Myong; Kim, Dae Hwan

    2011-01-01

    The physical origins of the negative bias illumination stress (NBIS)-induced threshold voltage shift (ΔV T ) in amorphous InGaZnO (a-IGZO) thin-film transistors (TFTs) under ambient light from a backlight unit are quantitatively and systematically investigated. Furthermore, a methodology for extracting the instability parameters is proposed and demonstrated. For the quantitative analysis, the subgap density-of-states (DOS)-based DC I-V model is intensively used. The NBIS time-evolution of the measured I DS -V GS characteristics is reproduced very well via the proposed methodology and instability parameters. Consequently, photo-excited electron detrapping, followed by ionization of oxygen vacancies (V O +2 ) and field-enhanced V O +2 diffusion, followed by hole trapping into the gate insulator, are found to be the dominant mechanisms in NBIS-induced instability of a-IGZO TFTs.

  1. Genomic mutation study for long-term cells induced by carbon ions

    International Nuclear Information System (INIS)

    Wang, X.; Furusawa, Y.; Suzuki, M.; Hirayama, R.; Matsumoto, Y.; Qin, Y.

    2007-01-01

    Complete text of publication follows. Objective: Densely ionizing (high LET) radiation can increase the relative biological effectiveness of cell and tissue. Astronauts in the space exploration have the potential exposure of chronic low-dose radiations in the field of low-flux galactic cosmic rays (GCR) and the subsequent biological effects have become one of the major concerns of space science. Furthermore, Heavy ions also are used new radiation therapy owing increased lethal effectiveness of high LET radiation. During radiation therapy, normal tissues also are exposed to ionizing radiation. Radiation can induce genomic mutation and instability in descendants of irradiated cells. Induction of genomic instability can represent one of the initiating steps leading to malignant transformation. Higher frequencies of mutation can be expected to provide higher rates of carcinogenicity with human exposure. Therefore, the study of radiation induced genomic mutation and instability is relevant to the estimates of the risk of secondary malignancies associated with radiation therapy and the carcinogenic effects of space environmental radiation. The hypoxanthine-guanine phosphoribosyltransferase (hprt) locus has been the most commonly used as a target gene for mutation detection studies. In this study, we investigated the generation expression dependence of mutation induction on HPRT locus in CHO cells irradiated with carbon ions. Methods: Chinese hamster ovary (CHO) cells were irradiated with graded doses of carbon ions (290MeV/u, LET:13kev/um) accelerated with Heavy Ion Medical Accelerator in Chiba (HIMAC) at National Institute of Radiological Sciences(NIRS). The survival effect of cells plated immediately after irradiation was measured with cell colony formation assay. After irradiation, cells were continues reseeding and cultures for lone-term proliferation. Cell samples were collected at 6, 12, 18, 24, 30, 37 and 44 days post irradiation. Mutation induction of cell

  2. Majority of Solar Wind Intervals Support Ion-Driven Instabilities

    Science.gov (United States)

    Klein, K. G.; Alterman, B. L.; Stevens, M. L.; Vech, D.; Kasper, J. C.

    2018-05-01

    We perform a statistical assessment of solar wind stability at 1 AU against ion sources of free energy using Nyquist's instability criterion. In contrast to typically employed threshold models which consider a single free-energy source, this method includes the effects of proton and He2 + temperature anisotropy with respect to the background magnetic field as well as relative drifts between the proton core, proton beam, and He2 + components on stability. Of 309 randomly selected spectra from the Wind spacecraft, 53.7% are unstable when the ion components are modeled as drifting bi-Maxwellians; only 4.5% of the spectra are unstable to long-wavelength instabilities. A majority of the instabilities occur for spectra where a proton beam is resolved. Nearly all observed instabilities have growth rates γ slower than instrumental and ion-kinetic-scale timescales. Unstable spectra are associated with relatively large He2 + drift speeds and/or a departure of the core proton temperature from isotropy; other parametric dependencies of unstable spectra are also identified.

  3. Heavy-ion radiation induced bystander effect in mice

    Science.gov (United States)

    Liang, Shujian; Sun, Yeqing; Zhang, Meng; Wang, Wei; Cui, Changna

    2012-07-01

    Radiation-induced bystander effect is defined as the induction of damage in neighboring non-hit cells by signals released from directly-irradiated cells. Recently, Low dose of high LET radiation induced bystander effects in vivo have been reported more and more. It has been indicated that radiation induced bystander effect was localized not only in bystander tissues but also in distant organs. Genomic, epigenetic, metabolomics and proteomics play significant roles in regulating heavy-ion radiation stress responses in mice. To identify the molecular mechanism that underlies bystander effects of heavy-ion radiation, the male mice head were exposed to 2000mGy dose of 12C heavy-ion radiation and the distant organ liver was detected on 1h, 6h, 12h and 24h after radiation, respectively. MSAP was used to monitor the level of polymorphic DNA methylation changes. The results show that heavy-ion irradiate mouse head can induce liver DNA methylation changes significantly. The percent of DNA methylation changes are time-dependent and highest at 6h after radiation. We also prove that the hypo-methylation changes on 1h and 6h after irradiation. But the expression level of DNA methyltransferase DNMT3a is not changed. UPLC/Synapt HDMS G2 was employed to detect the proteomics of bystander liver 1h after irradiation. 64 proteins are found significantly different between treatment and control group. GO process show that six of 64 which were unique in irradiation group are associated with apoptosis and DNA damage response. The results suggest that mice head exposed to heavy-ion radiation can induce damage and methylation pattern changed in distant organ liver. Moreover, our findings are important to understand the molecular mechanism of radiation induced bystander effects in vivo.

  4. A study of radiation-induced cerebral vascular injury in nasopharyngeal carcinoma patients with radiation-induced temporal lobe necrosis.

    Directory of Open Access Journals (Sweden)

    Jianhong Ye

    Full Text Available To investigate radiation-induced carotid and cerebral vascular injury and its relationship with radiation-induced temporal lobe necrosis in nasopharyngeal carcinoma (NPC patients.Fifty eight NPC patients with radiation-induced temporal lobe necrosis (TLN were recruited in the study. Duplex ultrasonography was used to scan bilateral carotid arterials to evaluate the intima-media thickness (IMT and occurrence of plaque formation. Flow velocities of bilateral middle cerebral arteries (MCAs, internal carotid arteries (ICAs and basal artery (BA were estimated through Transcranial Color Doppler (TCD. The results were compared with data from 33 patients who were free from radiation-induced temporal lobe necrosis after radiotherapy and 29 healthy individuals.Significant differences in IMT, occurrence of plaques of ICAs and flow velocities of both MCAs and ICAs were found between patients after radiotherapy and healthy individuals (p<0.05. IMT had positive correlation with post radiation interval (p = 0.049. Compared with results from patients without radiation-induced TLN, the mean IMT was significantly thicker in patients with TLN (p<0.001. Plaques were more common in patients with TLN than patients without TLN (p = 0.038. In addition, flow velocities of MCAs and ICAs in patients with TLN were much faster (p<0.001, p<0.001. Among patients with unilateral TLN, flow velocity of MCAs was significantly different between ipsilateral and contralateral sides to the lesion (p = 0.001.Thickening of IMT, occurrence of plaque formation and hemodynamic abnormality are more common in patients after radiotherapy, especially in those with TLN, compared with healthy individuals.

  5. Modification of the collective Thomson scattering radiometer in the search for parametric decay on TEXTOR

    DEFF Research Database (Denmark)

    Nielsen, Stefan Kragh; Salewski, Mirko; Bongers, W.

    2012-01-01

    Strong scattering of high-power millimeter waves at 140 GHz has been shown to take place in heating and current-drive experiments at TEXTOR when a tearing mode is present in the plasma. The scattering signal is at present supposed to be generated by the parametric decay instability. Here we descr...

  6. Radiation physics, biophysics, and radiation biology

    International Nuclear Information System (INIS)

    Hall, E.J.

    1992-05-01

    The following research programs from the Center for Radiological Research of Columbia University are described: Design and development of a new wall-less ultra miniature proportional counter for nanodosimetry; some recent measurements of ionization distributions for heavy ions at nanometer site sizes with a wall-less proportional counter; a calculation of exciton energies in periodic systems with helical symmetry: application to a hydrogen fluoride chain; electron energy-loss function in polynucleotide and the question of plasmon excitation; a non-parametric, microdosimetric-based approach to the evaluation of the biological effects of low doses of ionizing radiation; high-LET radiation risk assessment at medium doses; high-LET radiobiological effects: increased lesion severity or increased lesion proximity; photoneutrons generated by high energy medical linacs; the biological effectiveness of neutrons; implications for radiation protection; molecular characterization of oncogenes induced by neutrons; and the inverse dose-rate effect for oncogenic transformation by charged particles is LET dependent

  7. Radiation-induced heart injury. Radiopathological study

    Energy Technology Data Exchange (ETDEWEB)

    Suzuki, Y; Niibe, H [Gunma Univ., Maebashi (Japan). School of Medicine

    1975-11-01

    In order to identify radiation-induced heart injury and to differentiate it from heart disease, an attempt was made to clarify post-irradiation heart injury by investigating the histological changes which occur during the interval between the irradiation and the time of demonstrable histological changes. A study was made of 83 autopsies in which most of the primary neoplasms were breast cancers, lung cancers and mediastinal tumors. In 43 of these autopsies the heart had been irradiated. Sixty eight dd-strain mice were also used for microautoradiographic study. Histological changes in the heart were observed in 27 of the 43 cases receiving irradiation. The limit of the tolerance dose to the heart for indicating histological changes was 1220 ret in humans. The latent period without histological changes was 2.7 months after initiation of radiation therapy. Greater heart injury was observed after re-irradiation or after the combined therapy of radiation and chemotherapy especially mitomycin (MMC). The histological findings after treatment with MMC were similar to those of radiation-induced heart injury. Results of the study indicate that the damage is secondary to radiation-induced changes of the vascula connective tissue.

  8. Relativistic gravitational instabilities

    International Nuclear Information System (INIS)

    Schutz, B.F.

    1987-01-01

    The purpose of these lectures is to review and explain what is known about the stability of relativistic stars and black holes, with particular emphases on two instabilities which are due entirely to relativistic effects. The first of these is the post-Newtonian pulsational instability discovered independently by Chandrasekhar (1964) and Fowler (1964). This effectively ruled out the then-popular supermassive star model for quasars, and it sets a limit to the central density of white dwarfs. The second instability was also discovered by Chandrasekhar (1970): the gravitational wave induced instability. This sets an upper bound on the rotation rate of neutron stars, which is near that of the millisecond pulsar PSR 1937+214, and which is beginning to constrain the equation of state of neutron matter. 111 references, 5 figures

  9. Assessment of radiation damage - the need for a multi-parametric and integrative approach with the help of both clinical and biological dosimetry

    International Nuclear Information System (INIS)

    Meineke, Viktor

    2008-01-01

    Full text: Accidental exposure to ionising radiation leads to a damage on different levels of the biological organization of the organism. Depending on exposure conditions, such as nature of radiation, time and affected organs and organ systems, the clinical endpoint of radiation damage and the resulting acute and chronic radiation syndromes may vary to a great extent. Exposure situations range from pure localised radiation scenarios and partial body exposures up to whole body exposures. Therefore clinical pictures vary from localized radiation injuries up to the extreme situation of a radiation-induced multi-organ involvement and failure requiring immediate, intensive and interdisciplinary medical treatment. These total different and complex clinical situations not only show up most different clinical diagnostic and therapeutic aspects but necessarily due to different levels of the underlying biological damage, biological indicators of effects may vary to a wide extent. This fact means that an exact assessment of the extent of radiation damage within individual patients can only be performed when taking into consideration both clinical signs and symptoms as well as different biological indicators. Among the clinical indicators, routine laboratory parameters such as blood counts and the documentation of clinical signs and symptoms (such as the METREPOL system) are the key parameters, whereas the dicentric assay, the gold standard for biological dosimetry, but also methods under development such as the gamma-H2Ax focus assay or the estimation of variations of gene expression have to be taken into account. Each method provides best results in different situations, or in other words, there are methods that work better in a specific exposure condition or at a given time of examination (e.g. time after exposure) than others. Some methods show up results immediately, others require days to weeks until results are available for clinical decision making. Therefore to

  10. Parametric decay of an extraordinary electromagnetic wave in relativistic plasma

    Energy Technology Data Exchange (ETDEWEB)

    Dorofeenko, V. G. [Institute for Advanced Studies (Austria); Krasovitskiy, V. B., E-mail: krasovit@mail.ru [Keldysh Institute of Applied Mathematics (Russian Federation); Turikov, V. A. [Peoples’ Friendship University of Russia (Russian Federation)

    2015-03-15

    Parametric instability of an extraordinary electromagnetic wave in plasma preheated to a relativistic temperature is considered. A set of self-similar nonlinear differential equations taking into account the electron “thermal” mass is derived and investigated. Small perturbations of the parameters of the heated plasma are analyzed in the linear approximation by using the dispersion relation determining the phase velocities of the fast and slow extraordinary waves. In contrast to cold plasma, the evanescence zone in the frequency range above the electron upper hybrid frequency vanishes and the asymptotes of both branches converge. Theoretical analysis of the set of nonlinear equations shows that the growth rate of decay instability increases with increasing initial temperature of plasma electrons. This result is qualitatively confirmed by numerical simulations of plasma heating by a laser pulse injected from vacuum.

  11. Three-wave interaction during electron cyclotron resonance heating and current drive

    DEFF Research Database (Denmark)

    Nielsen, Stefan Kragh; Jacobsen, Asger Schou; Hansen, Søren Kjer

    2016-01-01

    Non-linear wave-wave interactions in fusion plasmas, such as the parametric decay instability (PDI) of gyrotron radiation, can potentially hamper the use of microwave diagnostics. Here we report on anomalous scattering in the ASDEX Upgrade tokamak during electron cyclotron resonance heating...... experiments. The observations can be linked to parametric decay of the gyrotron radiation at the second harmonic upper hybrid resonance layer....

  12. Cavitation instabilities in hydraulic machines

    International Nuclear Information System (INIS)

    Tsujimoto, Y

    2013-01-01

    Cavitation instabilities in hydraulic machines, hydro turbines and turbopump inducers, are reviewed focusing on the cause of instabilities. One-dimensional model of hydro turbine system shows that the overload surge is caused by the diffuser effect of the draft tube. Experiments show that this effect also causes the surge mode oscillations at part load. One dimensional model of a cavitating turbopump inducer shows that the mass flow gain factor, representing the cavity volume increase caused by the incidence angle increase is the cause of cavitation surge and rotating cavitation. Two dimensional model of a cavitating turbopump inducer shows that various modes of cavitation instabilities start to occur when the cavity length becomes about 65% of the blade spacing. This is caused by the interaction of the local flow near the cavity trailing edge with the leading edge of the next blade. It was shown by a 3D CFD that this is true also for real cases with tip cavitation. In all cases, it was shown that cavitation instabilities are caused by the fundamental characteristics of cavities that the cavity volume increases with the decrease of ambient pressure or the increase of the incidence angle

  13. Secondary Instability of Second Modes in Hypersonic Boundary Layers

    Science.gov (United States)

    Li, Fei; Choudhari, Meelan M.; Chang, Chau-Lyan; White, Jeffery A.

    2012-01-01

    Second mode disturbances dominate the primary instability stage of transition in a number of hypersonic flow configurations. The highest amplification rates of second mode disturbances are usually associated with 2D (or axisymmetric) perturbations and, therefore, a likely scenario for the onset of the three-dimensionality required for laminar-turbulent transition corresponds to the parametric amplification of 3D secondary instabilities in the presence of 2D, finite amplitude second mode disturbances. The secondary instability of second mode disturbances is studied for selected canonical flow configurations. The basic state for the secondary instability analysis is obtained by tracking the linear and nonlinear evolution of 2D, second mode disturbances using nonlinear parabolized stability equations. Unlike in previous studies, the selection of primary disturbances used for the secondary instability analysis was based on their potential relevance to transition in a low disturbance environment and the effects of nonlinearity on the evolution of primary disturbances was accounted for. Strongly nonlinear effects related to the self-interaction of second mode disturbances lead to an upstream shift in the upper branch neutral location. Secondary instability computations confirm the previously known dominance of subharmonic modes at relatively small primary amplitudes. However, for the Purdue Mach 6 compression cone configuration, it was shown that a strong fundamental secondary instability can exist for a range of initial amplitudes of the most amplified second mode disturbance, indicating that the exclusive focus on subharmonic modes in the previous applications of secondary instability theory to second mode primary instability may not have been fully justified.

  14. Radiation-induced degradation of pollutants

    International Nuclear Information System (INIS)

    Proksch, E.

    1988-01-01

    This article outlines the fundamentals of radiation-induced degradation of noxious substances in drinking water and waste water and discusses the relevant literature. Radiation methods present a number of advantages and disadvantages, which should carefully be considered in each case. In many cases, there seems to be merit in combining the radiation method with other techniques, as e.g. ozone treatement and biodegradation. 30 refs., 3 figs. (Author)

  15. The general dispersion relation of induced streaming instabilities in quantum outflow systems

    Energy Technology Data Exchange (ETDEWEB)

    Mehdian, H., E-mail: mehdian@khu.ac.ir; Hajisharifi, K.; Hasanbeigi, A. [Department of Physics and Institute for Plasma Research, Kharazmi University, 49 Dr Mofatteh Avenue, Tehran 15614 (Iran, Islamic Republic of)

    2015-11-15

    In this manuscript the dispersion relations of streaming instabilities, by using the unique property (neutralized in charge and current by default) of plasma shells colliding, have been generalized and studied. This interesting property for interpenetrating beams enables one to find the general dispersion relations without any restrictions used in the previous works in this area. In our previous work [H. Mehdian et al., ApJ. 801, 89 (2015)], employing the plasma shell concept and boost frame method, the general dispersion relation for filamentation instability has been derived in the relativistic classical regime. But in this paper, using the above mentioned concepts, the general dispersion relations (for each of streaming instabilities, filamentation, two-stream and multi-stream) in the non-relativistic quantum regime have been derived by employing the quantum fluid equations together with Maxwell equations. The derived dispersion relations enable to describe any arbitrary system of interacting two and three beams, justified neutralization condition, by choosing the inertial reference frame embedded on the one of the beams. Furthermore, by the numerical and analytical study of these dispersion relations, many new features of streaming instabilities (E.g. their cut-off wave numbers and growth rates) in terms of all involved parameters have been illustrated. The obtained results in this paper can be used to describe many astrophysical systems and laboratory astrophysics setting, such as collision of non-parallel plasma shells over a background plasma or the collision of three neutralized plasma slabs, and justifying the many plasma phenomena such as particle accelerations and induced fields.

  16. Pyruvate metabolism: A therapeutic opportunity in radiation-induced skin injury

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Hyun; Kang, Jeong Wook [Department of Radiation Oncology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752 (Korea, Republic of); Lee, Dong Won [Department of Plastic Surgery, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752 (Korea, Republic of); Oh, Sang Ho [Department of Dermatology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752 (Korea, Republic of); Lee, Yun-Sil [College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewah Womans University, Seoul 120-750 (Korea, Republic of); Lee, Eun-Jung [Department of Radiation Oncology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752 (Korea, Republic of); Cho, Jaeho, E-mail: jjhmd@yuhs.ac [Department of Radiation Oncology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752 (Korea, Republic of)

    2015-05-08

    Ionizing radiation is used to treat a range of cancers. Despite recent technological progress, radiation therapy can damage the skin at the administration site. The specific molecular mechanisms involved in this effect have not been fully characterized. In this study, the effects of pyruvate, on radiation-induced skin injury were investigated, including the role of the pyruvate dehydrogenase kinase 2 (PDK2) signaling pathway. Next generation sequencing (NGS) identified a wide range of gene expression differences between the control and irradiated mice, including reduced expression of PDK2. This was confirmed using Q-PCR. Cell culture studies demonstrated that PDK2 overexpression and a high cellular pyruvate concentration inhibited radiation-induced cytokine expression. Immunohistochemical studies demonstrated radiation-induced skin thickening and gene expression changes. Oral pyruvate treatment markedly downregulated radiation-induced changes in skin thickness and inflammatory cytokine expression. These findings indicated that regulation of the pyruvate metabolic pathway could provide an effective approach to the control of radiation-induced skin damage. - Highlights: • The effects of radiation on skin thickness in mice. • Next generation sequencing revealed that radiation inhibited pyruvate dehydrogenase kinase 2 expression. • PDK2 inhibited irradiation-induced cytokine gene expression. • Oral pyruvate treatment markedly downregulated radiation-induced changes in skin thickness.

  17. The induction of genomic instability in related human lymphoblasts following exposure to Cs gamma radiation vs accelerated 56Fe Ions

    International Nuclear Information System (INIS)

    Evans, H.H.; Horng, M.-F.; Ricanati, M.; Diaz-Insua, M.

    2003-01-01

    Full text: The induction of genomic instability by exposure to Cs-137 gamma radiation and Fe-56 accelerated ions was investigated by measuring the frequency and characteristics of TK6 and WTK1 unstable clones isolated 36 generations after exposure. While the two cell lines are related, TK6 is more sensitive to radiation, has normal p53 expression, and is repair deficient. Clones surviving the radiation and respective controls were analyzed for 17 characteristics including chromosomal aberrations, growth defects, alterations in response to a second radiation and mutant frequencies at two different loci. Putative unstable clones were defined as those exhibiting a significant alteration in one or more characteristics as compared to the respective control medians. Over half of the unstable WTK1 clones and over 90% of the TK6 unstable clones surviving exposure to either radiation exhibited chromosomal instability, the major aberrations consisting of chromatid breaks and dicentric chromosomes formed by end-to-end fusions. Alterations in the other measured characteristics occurred much less often than cytogenetic alterations in the TK6 unstable clones. The phenotype of the WTK1 unstable clones was more diverse and complex than in the case of TK6 unstable clones. The phenotype of the TK6 unstable clones differed in the survivors of Cs-137 vs. Fe-56. In the clones surviving Cs-137, the aberrations consisted mainly of dicentric chromosomes, while clones surviving exposure to Fe-56 exhibited both breaks and dicentrics. The uniform prevalence of chromosomal aberrations in the unstable TK6 clones vs. the relatively diverse phenotype of the unstable WTK1 clones suggests that the deficiency in DNA double-strand break repair in TK6 cells may be accompanied by a deficiency in telomere maintenance that leads to telomere fusion, dicentric chromosomes, anaphase bridges, breakage and the occurrence of chromosomal instability in the majority of clones isolated following exposure

  18. Non-thermal plasma instabilities induced by deformation of the electron energy distribution function

    Science.gov (United States)

    Dyatko, N. A.; Kochetov, I. V.; Napartovich, A. P.

    2014-08-01

    Non-thermal plasma is a key component in gas lasers, microelectronics, medical applications, waste gas cleaners, ozone generators, plasma igniters, flame holders, flow control in high-speed aerodynamics and others. A specific feature of non-thermal plasma is its high sensitivity to variations in governing parameters (gas composition, pressure, pulse duration, E/N parameter). This sensitivity is due to complex deformations of the electron energy distribution function (EEDF) shape induced by variations in electric field strength, electron and ion number densities and gas excitation degree. Particular attention in this article is paid to mechanisms of instabilities based on non-linearity of plasma properties for specific conditions: gas composition, steady-state and decaying plasma produced by the electron beam, or by an electric current pulse. The following effects are analyzed: the negative differential electron conductivity; the absolute negative electron mobility; the stepwise changes of plasma properties induced by the EEDF bi-stability; thermo-current instability and the constriction of the glow discharge column in rare gases. Some of these effects were observed experimentally and some of them were theoretically predicted and still wait for experimental confirmation.

  19. Coherent Synchrotron Radiation A Simulation Code Based on the Non-Linear Extension of the Operator Splitting Method

    CERN Document Server

    Dattoli, Giuseppe

    2005-01-01

    The coherent synchrotron radiation (CSR) is one of the main problems limiting the performance of high intensity electron accelerators. A code devoted to the analysis of this type of problems should be fast and reliable: conditions that are usually hardly achieved at the same time. In the past, codes based on Lie algebraic techniques have been very efficient to treat transport problem in accelerators. The extension of these method to the non-linear case is ideally suited to treat CSR instability problems. We report on the development of a numerical code, based on the solution of the Vlasov equation, with the inclusion of non-linear contribution due to wake field effects. The proposed solution method exploits an algebraic technique, using exponential operators implemented numerically in C++. We show that the integration procedure is capable of reproducing the onset of an instability and effects associated with bunching mechanisms leading to the growth of the instability itself. In addition, parametric studies a...

  20. Causes of genome instability: the effect of low dose chemical exposures in modern society

    Science.gov (United States)

    Langie, Sabine A.S.; Koppen, Gudrun; Desaulniers, Daniel; Al-Mulla, Fahd; Al-Temaimi, Rabeah; Amedei, Amedeo; Azqueta, Amaya; Bisson, William H.; Brown, Dustin; Brunborg, Gunnar; Charles, Amelia K.; Chen, Tao; Colacci, Annamaria; Darroudi, Firouz; Forte, Stefano; Gonzalez, Laetitia; Hamid, Roslida A.; Knudsen, Lisbeth E.; Leyns, Luc; Lopez de Cerain Salsamendi, Adela; Memeo, Lorenzo; Mondello, Chiara; Mothersill, Carmel; Olsen, Ann-Karin; Pavanello, Sofia; Raju, Jayadev; Rojas, Emilio; Roy, Rabindra; Ryan, Elizabeth; Ostrosky-Wegman, Patricia; Salem, Hosni K.; Scovassi, Ivana; Singh, Neetu; Vaccari, Monica; Van Schooten, Frederik J.; Valverde, Mahara; Woodrick, Jordan; Zhang, Luoping; van Larebeke, Nik; Kirsch-Volders, Micheline; Collins, Andrew R.

    2015-01-01

    Genome instability is a prerequisite for the development of cancer. It occurs when genome maintenance systems fail to safeguard the genome’s integrity, whether as a consequence of inherited defects or induced via exposure to environmental agents (chemicals, biological agents and radiation). Thus, genome instability can be defined as an enhanced tendency for the genome to acquire mutations; ranging from changes to the nucleotide sequence to chromosomal gain, rearrangements or loss. This review raises the hypothesis that in addition to known human carcinogens, exposure to low dose of other chemicals present in our modern society could contribute to carcinogenesis by indirectly affecting genome stability. The selected chemicals with their mechanisms of action proposed to indirectly contribute to genome instability are: heavy metals (DNA repair, epigenetic modification, DNA damage signaling, telomere length), acrylamide (DNA repair, chromosome segregation), bisphenol A (epigenetic modification, DNA damage signaling, mitochondrial function, chromosome segregation), benomyl (chromosome segregation), quinones (epigenetic modification) and nano-sized particles (epigenetic pathways, mitochondrial function, chromosome segregation, telomere length). The purpose of this review is to describe the crucial aspects of genome instability, to outline the ways in which environmental chemicals can affect this cancer hallmark and to identify candidate chemicals for further study. The overall aim is to make scientists aware of the increasing need to unravel the underlying mechanisms via which chemicals at low doses can induce genome instability and thus promote carcinogenesis. PMID:26106144

  1. The plastic instability of clamped-clamped conical thin-walled pipe reducers

    International Nuclear Information System (INIS)

    Awad, Ibrahim; Saleh, Ch.A.R.; Ragab, A.R.

    2016-01-01

    The analytical study for plastic deformation of clamped–clamped conical reducer pipe under internal pressure does not deduce a closed form expression for the pressure at plastic instability. The presented study employs finite element analysis (FEA) to estimate the internal pressure at instability for conical reducers made of different materials and having different dimensional configurations. Forty dimensional configurations, classified as medium type, and five types of materials have been included in the analysis using ABAQUS package. A correlation expression is derived by nonlinear regression to predict the instability pressure. The proposed expression is verified for other dimensional configurations out of the above used forty models and for other materials. Experiments have been conducted by pressurizing conical clamped-clamped reducers until bursting in order to verify the finite element models. Comparison of instability pressures, strains and deflections at specific points along the conical surface shows satisfactory agreement between analysis and experiments. - Highlights: • This study offers a parametric study of the plastic instability pressure of clamped-clamped conical reducers. • A closed form analytical expression for the instability pressure is derived by using nonlinear regression. • The finite element analysis is validated by conducting bursting tests.

  2. Basic reactions induced by radiation

    International Nuclear Information System (INIS)

    Charlesby, A.

    1980-01-01

    This paper summarises some of the basic reactions resulting from exposure to high energy radiation. In the initial stages energy is absorbed, but not necessarily at random, giving radical and ion species which may then react to promote the final chemical change. However, it is possible to intervene at intermediate stages to modify or reduce the radiation effect. Under certain conditions enhanced reactions are also possible. Several expressions are given to calculate radiation yield in terms of energy absorbed. Some analogies between radiation-induced reactions in polymers, and those studied in radiobiology are outlined. (author)

  3. Radiation-Induced Differentiation in Human Lung Fibroblast

    International Nuclear Information System (INIS)

    Park, Sa-Rah; Ahn, Ji-Yeon; Han, Young-Soo; Shim, Jie-Young; Yun, Yeon-Sook; Song, Jie-Young

    2007-01-01

    One of the most common tumors in many countries is lung cancer and patients with lung cancer may take radiotherapy. Although radiotherapy may have its own advantages, it can also induce serious problems such as acute radiation pneumonitis and pulmonary fibrosis. Pulmonary fibrosis is characterized by excessive production of α-SMA and accumulation of extracellular matrix (ECM) such as collagen and fibronectin. There has been a great amount of research about fibrosis but the exact mechanism causing the reaction is not elucidated especially in radiation-induced fibrosis. Until now it has been known that several factors such as transforming growth factor (TGF-β), tumor necrosis factor (TNF), interleukin (IL)-1, IL-6, platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) are related to fibrosis. Among them TGF-β with Smad signaling is known to be the main stream and other signaling molecules such as MAPK, ERK and JNK (3) also participates in the process. In addition to those above factors, it is thought that more diverse and complicate mechanisms may involve in the radiationinduced fibrosis. Therefore, to investigate the underlying mechanisms in radiation induced fibrosis, first of all, we confirmed whether radiation induces trans differentiation in human normal lung fibroblasts. Here, we suggest that not only TGF-β but also radiation can induce trans differentiation in human lung fibroblast WI-38 and IMR-90

  4. On Parametric (and Non-Parametric Variation

    Directory of Open Access Journals (Sweden)

    Neil Smith

    2009-11-01

    Full Text Available This article raises the issue of the correct characterization of ‘Parametric Variation’ in syntax and phonology. After specifying their theoretical commitments, the authors outline the relevant parts of the Principles–and–Parameters framework, and draw a three-way distinction among Universal Principles, Parameters, and Accidents. The core of the contribution then consists of an attempt to provide identity criteria for parametric, as opposed to non-parametric, variation. Parametric choices must be antecedently known, and it is suggested that they must also satisfy seven individually necessary and jointly sufficient criteria. These are that they be cognitively represented, systematic, dependent on the input, deterministic, discrete, mutually exclusive, and irreversible.

  5. Radiation-Induced Alopecia after Endovascular Embolization under Fluoroscopy

    Directory of Open Access Journals (Sweden)

    Vipawee Ounsakul

    2016-01-01

    Full Text Available Radiation-induced alopecia after fluoroscopically guided procedures is becoming more common due to an increasing use of endovascular procedures. It is characterized by geometric shapes of nonscarring alopecia related to the area of radiation. We report a case of a 46-year-old man presenting with asymptomatic, sharply demarcated rectangular, nonscarring alopecic patch on the occipital scalp following cerebral angiography with fistula embolization under fluoroscopy. His presentations were compatible with radiation-induced alopecia. Herein, we also report a novel scalp dermoscopic finding of blue-grey dots in a target pattern around yellow dots and follicles, which we detected in the lesion of radiation-induced alopecia.

  6. Frequency-dependent Alfvén-wave Propagation in the Solar Wind: Onset and Suppression of Parametric Decay Instability

    Science.gov (United States)

    Shoda, Munehito; Yokoyama, Takaaki; Suzuki, Takeru K.

    2018-06-01

    Using numerical simulations we investigate the onset and suppression of parametric decay instability (PDI) in the solar wind, focusing on the suppression effect by the wind acceleration and expansion. Wave propagation and dissipation from the coronal base to 1 au is solved numerically in a self-consistent manner; we take into account the feedback of wave energy and pressure in the background. Monochromatic waves with various injection frequencies, f 0, are injected to discuss the suppression of PDI, while broadband waves are applied to compare the numerical results with observation. We find that high-frequency ({f}0≳ {10}-3 {Hz}) Alfvén waves are subject to PDI. Meanwhile, the maximum growth rate of the PDI of low-frequency ({f}0≲ {10}-4 {Hz}) Alfvén waves becomes negative due to acceleration and expansion effects. Medium-frequency ({f}0≈ {10}-3.5 {Hz}) Alfvén waves have a positive growth rate but do not show the signature of PDI up to 1 au because the growth rate is too small. The medium-frequency waves experience neither PDI nor reflection so they propagate through the solar wind most efficiently. The solar wind is shown to possess a frequency-filtering mechanism with respect to Alfvén waves. The simulations with broadband waves indicate that the observed trend of the density fluctuation is well explained by the evolution of PDI while the observed cross-helicity evolution is in agreement with low-frequency wave propagation.

  7. Parametric excitation of very low frequency (VLF) electromagnetic whistler waves and interaction with energetic electrons in radiation belt

    Science.gov (United States)

    Sotnikov, V.; Kim, T.; Caplinger, J.; Main, D.; Mishin, E.; Gershenzon, N.; Genoni, T.; Paraschiv, I.; Rose, D.

    2018-04-01

    The concept of a parametric antenna in ionospheric plasma is analyzed. Such antennas are capable of exciting electromagnetic radiation fields, specifically the creation of whistler waves generated at the very low frequency (VLF) range, which are also capable of propagating large distances away from the source region. The mechanism of whistler wave generation is considered a parametric interaction of quasi-electrostatic whistler waves (also known as low oblique resonance (LOR) oscillations) excited by a conventional loop antenna. The interaction of LOR waves with quasi-neutral density perturbations in the near field of an antenna gives rise to electromagnetic whistler waves on combination frequencies. It is shown in this work that the amplitude of these waves can considerably exceed the amplitude of whistler waves directly excited by a loop. Additionally, particle-in-cell simulations, which demonstrate the excitation and spatial structure of VLF waves excited by a loop antenna, are presented. Possible applications including the wave-particle interactions to mitigate performance anomalies of low Earth orbit satellites, active space experiments, communication via VLF waves, and modification experiments in the ionosphere will be discussed.

  8. Radiation-induced neuropathies: collateral damage of improved cancer prognosis

    International Nuclear Information System (INIS)

    Pradat, Pierre-Francois; Maisonobe, Thierry; Psimaras, Dimitri; Lenglet, Timothee; Porcher, Raphael; Lefaix, J.L.; Delenian, S.

    2012-01-01

    Because of the improvement of cancer prognosis, long-term damages of treatments become a medical and public health problem. Among the iatrogenic complications, neurological impairment is crucial to consider since motor disability and pain have a considerable impact on quality of life of long cancer survivors. However, radiation-induced neuropathies have not been the focus of great attention. The objective of this paper is to provide an updated review about the radiation-induced lesions of the peripheral nerve system. Radiation-induced neuropathies are characterized by their heterogeneity in both symptoms and disease course. Signs and symptoms depend on the affected structures of the peripheral nerve system (nerve roots, nerve plexus or nerve trunks). Early-onset complications are often transient and late complications are usually progressive and associated with a poor prognosis. The most frequent and well known is delayed radiation-induced brachial plexopathy, which may follow breast cancer irradiation. Radiation-induced lumbosacral radiculoplexopathy is characterized by pure or predominant lower motor neuron signs. They can be misdiagnosed, confused with amyotrophic lateral sclerosis (ALS) or with leptomeningeal metastases since nodular MRI enhancement of the nerve roots of the cauda equina and increased cerebrospinal fluid protein content can be observed. In the absence of specific markers of the link with radiotherapy, the diagnosis of post-radiation neuropathy may be difficult. Recently, a posteriori conformal radiotherapy with 3D dosimetric reconstitution has been developed to link a precise anatomical site to unexpected excess irradiation. The importance of early diagnosis of radiation-induced neuropathies is underscored by the emergence of new disease-modifying treatments. Although the pathophysiology is not fully understood, it is already possible to target radiation-induced fibrosis but also associated factors such as ischemia, oxidative stress and

  9. Parametric Amplification of Gravitational Fluctuations during Reheating

    International Nuclear Information System (INIS)

    Finelli, F.; Brandenberger, R.; Finelli, F.

    1999-01-01

    Cosmological perturbations can undergo amplification by parametric resonance during preheating even on scales larger than the Hubble radius, without violating causality. A unified description of gravitational and matter fluctuations is crucial to determine the strength of the instability. To extract specific signatures of the oscillating inflaton field during reheating, it is essential to focus on a variable describing metric fluctuations which is constant in the standard analyses of inflation. For a massive inflaton without self-coupling, we find no additional growth of superhorizon modes during reheating beyond the usual predictions. For a massless self-coupled inflaton, there is a sub-Hubble scale resonance. copyright 1999 The American Physical Society

  10. Hexavalent chromium induces chromosome instability in human urothelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Wise, Sandra S. [Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, Department of Applied Medical Science, University of Southern Maine, Science Building, 96 Falmouth Street, Portland, ME 04103 (United States); Holmes, Amie L. [Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, Department of Applied Medical Science, University of Southern Maine, Science Building, 96 Falmouth Street, Portland, ME 04103 (United States); Department of Radiation Oncology, Dana Farber Cancer Institute, 450 Brookline Ave., Boston, MA 02215 (United States); Liou, Louis [Department of Pathology, Boston University School of Medicine, 670 Albany St., Boston, MA 02118 (United States); Adam, Rosalyn M. [Department of Surgery, Harvard Medical School, Boston, MA 02115 (United States); Wise, John Pierce Sr., E-mail: john.wise@louisville.edu [Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, Department of Applied Medical Science, University of Southern Maine, Science Building, 96 Falmouth Street, Portland, ME 04103 (United States)

    2016-04-01

    Numerous metals are well-known human bladder carcinogens. Despite the significant occupational and public health concern of metals and bladder cancer, the carcinogenic mechanisms remain largely unknown. Chromium, in particular, is a metal of concern as incidences of bladder cancer have been found elevated in chromate workers, and there is an increasing concern for patients with metal hip implants. However, the impact of hexavalent chromium (Cr(VI)) on bladder cells has not been studied. We compared chromate toxicity in two bladder cell lines; primary human urothelial cells and hTERT-immortalized human urothelial cells. Cr(VI) induced a concentration- and time-dependent increase in chromosome damage in both cell lines, with the hTERT-immortalized cells exhibiting more chromosome damage than the primary cells. Chronic exposure to Cr(VI) also induced a concentration-dependent increase in aneuploid metaphases in both cell lines which was not observed after a 24 h exposure. Aneuploidy induction was higher in the hTERT-immortalized cells. When we correct for uptake, Cr(VI) induces a similar amount of chromosome damage and aneuploidy suggesting that the differences in Cr(VI) sensitivity between the two cells lines were due to differences in uptake. The increase in chromosome instability after chronic chromate treatment suggests this may be a mechanism for chromate-induced bladder cancer, specifically, and may be a mechanism for metal-induced bladder cancer, in general. - Highlights: • Hexavalent chromium is genotoxic to human urothelial cells. • Hexavalent chromium induces aneuploidy in human urothelial cells. • hTERT-immortalized human urothelial cells model the effects seen in primary urothelial cells. • Hexavalent chromium has a strong likelihood of being carcinogenic for bladder tissue.

  11. Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

    International Nuclear Information System (INIS)

    Lentini, Laura; Amato, Angela; Schillaci, Tiziana; Di Leonardo, Aldo

    2007-01-01

    Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN). CIN is characterized by chromosomal aberrations, gains or losses of whole chromosomes (aneuploidy), and it is often associated with centrosome amplification. Centrosomes control cell division by forming a bipolar mitotic spindle and play an essential role in the maintenance of chromosomal stability. However, whether centrosome amplification could directly cause aneuploidy is not fully established. Also, alterations in genes required for mitotic progression could be involved in CIN. A major candidate is represented by Aurora-A/STK15 that associates with centrosomes and is overexpressed in several types of human tumour. Centrosome amplification were induced by hydroxyurea treatment and visualized by immunofluorescence microscopy. Aurora-A/STK15 ectopic expression was achieved by retroviral infection and puromycin selection in HCT116 tumour cells. Effects of Aurora-A/STK15 depletion on centrosome status and ploidy were determined by Aurora-A/STK15 transcriptional silencing by RNA interference. Changes in the expression levels of some mitotic genes were determined by Real time RT-PCR. We investigated whether amplification of centrosomes and overexpression of Aurora-A/STK15 induce CIN using as a model system a colon carcinoma cell line (HCT116). We found that in HCT116 cells, chromosomally stable and near diploid cells harbouring a MIN phenotype, centrosome amplification induced by hydroxyurea treatment is neither maintained nor induces aneuploidy. On the contrary, ectopic overexpression of Aurora-A/STK15 induced supernumerary centrosomes and aneuploidy. Aurora-A/STK15 transcriptional silencing by RNA interference in cells ectopically overexpressing this kinase promptly decreased cell numbers with supernumerary centrosomes and aneuploidy. Our results show that centrosome amplification alone is not sufficient

  12. Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

    Directory of Open Access Journals (Sweden)

    Schillaci Tiziana

    2007-11-01

    Full Text Available Abstract Background Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN. CIN is characterized by chromosomal aberrations, gains or losses of whole chromosomes (aneuploidy, and it is often associated with centrosome amplification. Centrosomes control cell division by forming a bipolar mitotic spindle and play an essential role in the maintenance of chromosomal stability. However, whether centrosome amplification could directly cause aneuploidy is not fully established. Also, alterations in genes required for mitotic progression could be involved in CIN. A major candidate is represented by Aurora-A/STK15 that associates with centrosomes and is overexpressed in several types of human tumour. Methods Centrosome amplification were induced by hydroxyurea treatment and visualized by immunofluorescence microscopy. Aurora-A/STK15 ectopic expression was achieved by retroviral infection and puromycin selection in HCT116 tumour cells. Effects of Aurora-A/STK15 depletion on centrosome status and ploidy were determined by Aurora-A/STK15 transcriptional silencing by RNA interference. Changes in the expression levels of some mitotic genes were determined by Real time RT-PCR. Results We investigated whether amplification of centrosomes and overexpression of Aurora-A/STK15 induce CIN using as a model system a colon carcinoma cell line (HCT116. We found that in HCT116 cells, chromosomally stable and near diploid cells harbouring a MIN phenotype, centrosome amplification induced by hydroxyurea treatment is neither maintained nor induces aneuploidy. On the contrary, ectopic overexpression of Aurora-A/STK15 induced supernumerary centrosomes and aneuploidy. Aurora-A/STK15 transcriptional silencing by RNA interference in cells ectopically overexpressing this kinase promptly decreased cell numbers with supernumerary centrosomes and aneuploidy. Conclusion Our

  13. Radiation induced mitotic delay and stimulation of growth

    International Nuclear Information System (INIS)

    Feldmann, A.

    1974-01-01

    The mechanisms responsible for the radiation induced mitotic delay and stimulation of growth are discussed in connection with the results of studies in Lemna minor and Lepidium sativum. The action of temperature seems to be of major importance. As many authors suggest that various chemical agents and slight intoxications also affect mitosis in a way similar to that induced by ionizing radiation, the radiation induced stimulation has lost its specific character and approaches might be found for further investigations of this phenomenon. (MG) [de

  14. Genetic instability model for cancer risk in A-bomb survivors

    International Nuclear Information System (INIS)

    Niwa, Ohtsura

    1998-01-01

    This review was written rather against Mendelsohn's reductionist model for cancer risk in A-bomb survivors in following chapters. Assumptions for carcinogenic process: mutation of a cell to the cancer cell and its proliferation. Multi-step theory for carcinogenesis and age of crisis: induction of cancer by accumulation of cancer-related gene mutations which being linear to time (age). Effect of exogenous hit in the multi-step theory: radiation as an exogenous hit to damage DNA. Dose-effect relationship for cancer risk in the survivors and the problem for the latent period: for solid tumors, dose-effect relationship is linear and shortening of the latent period is not observed. Considerations on cancer data in adulthood exposure/Indirect effect model in radiation carcinogenesis: solid cancer data supporting the indirect effect model. Possible mechanism for radiation-induced long-term increase of natural mutation frequency: genetic instability remaining in the irradiated cells which being a basis of the indirect effect model. Notes for considerations of carcinogenicity in exposed people/Difference in carcinogenic mechanisms due to age. The author concluded that the radiation-induced carcinogenesis is deeply related with the natural carcinogenesis and particularly for solid cancers, it can not be explained by the classic reductionist model. (K.H.)

  15. Radiation-induced apoptosis in F9 teratocarcinoma cells

    International Nuclear Information System (INIS)

    Langley, R.E.; Palayoor, S.T.; Coleman, C.N.; Bump, E.A.

    1994-01-01

    We have found that F9 murine teratocarcinoma cells undergo morphological changes and internucleosomal DNA fragmentation characteristic of apoptosis after exposure to ionizing radiation. We studied the time course, radiation dose-response, and the effects of protein and RNA synthesis inhibitors on this process. The response is dose dependent in the range 2-12 Gy. Internucleosomal DNA fragmentation can be detected as early as 6 h postirradiation and is maximal by 48 h. Cycloheximide, a protein synthesis inhibitor, and 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole, an RNA synthesis inhibitor, both induced internucleosomal DNA fragmentation in the unirradiated cells and enhanced radiation-induced DNA fragmentation. F9 cells can be induced to differentiate into cells resembling endoderm with retinoic acid. After irradiation, differentiated F9 cells exhibit less DNA fragmentation than stem cells. This indicates that ionizing radiation can induce apoptosis in non-lymphoid tumours. We suggest that embryonic tumour cells may be particularly susceptible to agents that induce apoptosis. (Author)

  16. Radiation-induced apoptosis in F9 teratocarcinoma cells

    Energy Technology Data Exchange (ETDEWEB)

    Langley, R E; Palayoor, S T; Coleman, C N; Bump, E A [Joint Center for Radiation Therapy and Dana Farber Cancer Inst., Boston (United States)

    1994-05-01

    We have found that F9 murine teratocarcinoma cells undergo morphological changes and internucleosomal DNA fragmentation characteristic of apoptosis after exposure to ionizing radiation. We studied the time course, radiation dose-response, and the effects of protein and RNA synthesis inhibitors on this process. The response is dose dependent in the range 2-12 Gy. Internucleosomal DNA fragmentation can be detected as early as 6 h postirradiation and is maximal by 48 h. Cycloheximide, a protein synthesis inhibitor, and 5,6-dichloro-1-[beta]-D-ribofuranosylbenzimidazole, an RNA synthesis inhibitor, both induced internucleosomal DNA fragmentation in the unirradiated cells and enhanced radiation-induced DNA fragmentation. F9 cells can be induced to differentiate into cells resembling endoderm with retinoic acid. After irradiation, differentiated F9 cells exhibit less DNA fragmentation than stem cells. This indicates that ionizing radiation can induce apoptosis in non-lymphoid tumours. We suggest that embryonic tumour cells may be particularly susceptible to agents that induce apoptosis. (Author).

  17. Radiation induced crosslinking of polytetrafluoroethylene

    International Nuclear Information System (INIS)

    Oshima, Akihiro; Tabata, Yoneho; Ikeda, Shigetoshi; Otsuhata, Kazushige; Kudoh, Hisaaki; Seguchi, Tadao.

    1995-01-01

    The Irradiation temperature effect on polytetrafluoroethylene (PTFE) from room temperature to 380degC was investigated by tensile test and thermal analysis. The behavior of tensile properties and changes of crystallinity on irradiation indicated the formation of a network structure in PTFE by radiation induced crosslinking in inert gas in the molten state just above the melting temperature of PTFE (327degC). The crosslinked PTFE showed a much improved radiation resistance in an atmospheric radiation field. (author)

  18. Study of radiation-induced chromosomal aberrations

    International Nuclear Information System (INIS)

    Wolfring, E.

    2004-06-01

    A method for determining chromosomal aberrations was established for the purpose of examining the relative biological effectiveness (RBE) of photon radiation with respect to mammary epithelium cells. Cells were exposed to 25 kV X-radiation and to 200 kV X-radiation for comparison and the resulting concentrations of chromosomal aberrations were compared. The RBE M value for radiation-induced fragmentation was found to be 4.2 ± 2.4, while the RBE M value for radiation-induced generation of dicentric chromosomes was found to be 0.5 ± 0.5. In addition to the evaluation of chromosomal aberrations the number of cell cycles undergone by the cells was monitored by means of BrDU staining. As expected, the proportion of cells which underwent more than one cell cycle following exposure to 5 Gy was very low in both cases, amounting to 1.9% (25 kV) and 3.2 (200 kV). Non-radiated cells yielded control values of 26.0% and 12.6%, suggesting variations in external conditions from day to day

  19. Cell cycle arrest induced by radiation

    International Nuclear Information System (INIS)

    Okaichi, Yasuo; Matsumoto, Hideki; Ohnishi, Takeo

    1994-01-01

    It is known that various chemical reactions, such as cell cycle arrest, DNA repair and cell killing, can occur within the cells when exposed to ionizing radiation and ultraviolet radiation. Thus protein dynamics involved in such chemical reactions has received considerable attention. In this article, cell cycle regulation is first discussed in terms of the G2/M-phase and the G1/S-phase. Then, radiation-induced cell cycle arrest is reviewed. Cell cycle regulation mechanism involved in the G2 arrest, which is well known to occur when exposed to radiation, has recently been investigated using yeasts. In addition, recent study has yielded a noticeable finding that the G1 arrest can occur with intracellular accumulation of p53 product following ionization radiation. p53 is also shown to play an extremely important role in both DNA repair and cell killing due to DNA damage. Studies on the role of genes in protein groups induced by radiation will hold promise for the elucidation of cell cycle mechanism. (N.K.) 57 refs

  20. Neutron star pulsations and instabilities

    International Nuclear Information System (INIS)

    Lindblom, L.

    2001-01-01

    Gravitational radiation (GR) drives an instability in certain modes of rotating stars. This instability is strong enough in the case of the r-modes to cause their amplitudes to grow on a timescale of tens of seconds in rapidly rotating neutron stars. GR emitted by these modes removes angular momentum from the star at a rate which would spin it down to a relatively small angular velocity within about one year, if the dimensionless amplitude of the mode grows to order unity. A pedagogical level discussion is given here on the mechanism of GR instability in rotating stars, on the relevant properties of the r-modes, and on our present understanding of the dissipation mechanisms that tend to suppress this instability in neutron stars. The astrophysical implications of this GR driven instability are discussed for young neutron stars, and for older systems such as low mass x-ray binaries. Recent work on the non-linear evolution of the r-modes is also presented. (author)