WorldWideScience

Sample records for radiation giving rise

  1. How effects of chemicals might differ from those of radiations in giving rise to genetic ill-health in man

    Evans, H.J.

    1980-01-01

    Possible differences between the effects of the two groups of agents are considered. Two types of genetic damage are discussed. The first type involves mutational changes induced in germ cells or germ cell precursors which are then transmitted to the products of conception and to any resultant offspring and their descendants. The second kind is that damage sustained by the genome in somatic cells which is transmitted to daughter cells. Such somatic mutations are not heritable in the familiar sense, but they are transmitted to descendant cells within the body. It is concluded that a greater heterogeneity is expected in mutagenic response to chemical mutagens than to radiations in human populations, that the spectrum of mutations following chemical exposure may be quite different from that following radiation exposure, and that for many chemical agents, and in contrast to ionising radiations, one might expect a greater burden of genetic ill-health due to increased frequencies of mildly deleterious recessive and polygenic mutations. (Auth.)

  2. Can False Advertising Give Rise to Antitrust Liability? (2)

    Christopher Cole

    2014-01-01

    With the Retractable Technologies case, is the theory that false advertising can give rise to violations of the Sherman Act, while rarely invoked, gaining traction? Christopher A. Cole (Crowell & Moring)

  3. Can False Advertising Give Rise to Antitrust Liability?

    Christopher Cole

    2014-01-01

    With the Retractable Technologies case, is the theory that false advertising can give rise to violations of the Sherman Act, while rarely invoked, gaining traction? Christopher A. Cole (Crowell & Moring)

  4. Royal Order of 28 March 1969 listing occupational diseases giving rise to compensation

    1969-01-01

    This Royal Order, made in implementation of the Act of 24 December 1963 on compensation for damage resulting from occupational diseases and prevention thereof, as amended by an Act fo 24 December 1968, lists the occupational diseases giving rise to compensation and includes those caused by ionizing radiations. The Order came into force on 1 July 1969 and repealed a previous Order of 18 January 1964 which laid down a first list of such diseases giving rise to compensation. (NEA) [fr

  5. Do spinors give rise to a frame-dragging effect?

    Randono, Andrew

    2010-01-01

    We investigate the effect of the intrinsic spin of a fundamental spinor field on the surrounding spacetime geometry. We show that despite the lack of a rotating stress-energy source (and despite claims to the contrary) the intrinsic spin of a spin-half fermion gives rise to a frame-dragging effect analogous to that of orbital angular momentum, even in Einstein-Hilbert gravity where torsion is constrained to be zero. This resolves a paradox regarding the counter-force needed to restore Newton's third law in the well-known spin-orbit interaction. In addition, the frame-dragging effect gives rise to a long-range gravitationally mediated spin-spin dipole interaction coupling the internal spins of two sources. We argue that despite the weakness of the interaction, the spin-spin interaction will dominate over the ordinary inverse square Newtonian interaction in any process of sufficiently high energy for quantum field theoretical effects to be non-negligible.

  6. Magma chamber interaction giving rise to asymmetric oscillations

    Walwer, D.; Ghil, M.; Calais, E.

    2017-12-01

    Geodetic time series at four volcanoes (Okmok, Akutan, Shishaldin, and Réunion) are processed using Multi-channel Singular Spectrum Analysis (M-SSA) and reveal sawtooth-shaped oscillations ; the latter are characterized by short intervals of fast inflations followed by longer intervals of slower deflations. At Okmok and Akutan, the oscillations are first damped and then accentuated. At Okmok, the increase in amplitude of the oscillations is followed by an eruption. We first show that the dynamics of these four volcanoes bears similarities with that of a simple nonlinear, dissipative oscillator, indicating that the inflation-deflation episodes are relaxation oscillations. These observations imply that ab initio dynamical models of magma chambers should possess an asymmetric oscillatory regime. Next, based on the work of Whitehead and Helfrich [1991], we show that a model of two magma chambers — connected by a cylindrical conduit in which the magma viscosity depends on temperature — gives rise to asymmetric overpressure oscillations in the magma reservoirs. These oscillations lead to surface deformations that are consistent with those observed at the four volcanoes in this study. This relaxation oscillation regime occurs only when the vertical temperature gradient in the host rock between the two magma chambers is large enough and when the magma flux entering the volcanic system is sufficiently high. The magma being supplied by a deeper source region, the input flux depends on the pressure difference between the source and the deepest reservoir. When this difference is not sufficiently high, the magma flux exponentially decreases, leading to damped oscillations as observed at Akutan and Okmok. The combination of observational and modeling results clearly supports the role of relaxation oscillations in the dynamics of volcanic systems.

  7. Purposeful Goal-Directed Movements Give Rise to Higher Tactile Discrimination Performance

    Georgiana Juravle

    2011-10-01

    Full Text Available Tactile perception is inhibited during goal-directed reaching movements (sensory suppression. Here, participants performed simple reaching or exploratory movements (where contact with the table surface was maintained. We measured tactile discrimination thresholds for vibratory stimuli delivered to participants' wrists while executing the movement, and while at rest. Moreover, we measured discrimination performance (in a same vs. different task for the materials covering the table surface, during the execution of the different movements. The threshold and discrimination tasks could be performed either singly or together, both under active movement and passive conditions (ie, no movement required, but with tactile stimulation. Thresholds measured at rest were significantly lower than thresholds measured during both active movements and passive touches. This provides a clear indication of sensory suppression during movement execution. Moreover, the discrimination data revealed main effects of task (single vs. dual, movement execution type (passive vs. active, and movement type (reach vs. exploration: Discrimination performance was significantly higher under conditions of single-tasking, active movements, as well as exploratory movements. Therefore, active movement of the hand with the purpose of gaining tactual information about the surface of the table gives rise to enhanced performance, thus suggesting that we feel more when we need to; It would appear that tactual information is prioritized when relevant for the movement being executed.

  8. Transitional paternalism: how shared normative powers give rise to the asymmetry of adolescent consent and refusal.

    Manson, Neil C

    2015-02-01

    In many jurisdictions, adolescents acquire the right to consent to treatment; but in some cases their refusals - e.g. of life-saving treatment - may not be respected. This asymmetry of adolescent consent and refusal seems puzzling, even incoherent. The aim here is to offer an original explanation, and a justification, of this asymmetry. Rather than trying to explain the asymmetry in terms of a variable standard of competence - where the adolescent is competent to consent to, but not refuse, certain interventions - the account offered here focuses more closely on the normative power to render actions permissible. Where normative powers are shared they can readily give rise to an asymmetry between consent and refusal. We then turn to why it is justifiable that normative powers be shared in adolescence. Transitional paternalism holds that the acquisition of normative powers by competent adolescents should not be an instant one, achieved in a single step, but that there should be a transitional period where paternalistic protection is rolled back, but not entirely withdrawn until a later date. Transitional paternalism could be implemented without generating the asymmetry between consent and refusal but, it is argued, the asymmetric version of transitional paternalism is to be preferred insofar as it offers a greater respect for the adolescent's decisions than the symmetrical alternative. © 2014 John Wiley & Sons Ltd.

  9. Human Liver Cells Expressing Albumin and Mesenchymal Characteristics Give Rise to Insulin-Producing Cells

    Irit Meivar-Levy

    2011-01-01

    Full Text Available Activation of the pancreatic lineage in the liver has been suggested as a potential autologous cell replacement therapy for diabetic patients. Transcription factors-induced liver-to-pancreas reprogramming has been demonstrated in numerous species both in vivo and in vitro. However, human-derived liver cells capable of acquiring the alternate pancreatic repertoire have never been characterized. It is yet unknown whether hepatic-like stem cells or rather adult liver cells give rise to insulin-producing cells. Using an in vitro experimental system, we demonstrate that proliferating adherent human liver cells acquire mesenchymal-like characteristics and a considerable level of cellular plasticity. However, using a lineage-tracing approach, we demonstrate that insulin-producing cells are primarily generated in cells enriched for adult hepatic markers that coexpress both albumin and mesenchymal markers. Taken together, our data suggest that adult human hepatic tissue retains a substantial level of developmental plasticity, which could be exploited in regenerative medicine approaches.

  10. Protein and peptide alkoxyl radicals can give rise to C-terminal decarboxylation and backbone cleavage

    Davies, Michael Jonathan

    1996-01-01

    Previous studies have demonstrated that gamma-irradiation of some free amino acids in the presence of oxygen gives high yields of side-chain hydroperoxides. It is shown in the present study that N-acetyl amino acids and peptides also give high levels of hydroperoxides on gamma-irradiation, even...

  11. IODP Expedition 324: Ocean Drilling at Shatsky Rise Gives Clues about Oceanic Plateau Formation

    Jörg Geldmacher

    2011-09-01

    Full Text Available Integrated Ocean Drilling Program (IODP Expedition 324 cored Shatsky Rise at five sites (U1346–U1350 to study processes of oceanic plateau formation and evolution. Site penetrations ranged from 191.8 m to 324.1 m with coring of 52.6 m to 172.7 m into igneous basement at four of the sites. Average recovery in basement was 38.7%–67.4%. Cored igneous sections consist mainly of variably evolved tholeiiticbasalts emplaced as pillows or massive flows. Massive flows are thickest and make up the largest percentage of section on the largest and oldest volcano, late Jurassic age Tamu Massif; thus, it may have formed at high effusion rates. Such massive flows are characteristic of flood basalts, and similar flows were cored at Ontong Java Plateau. Indeed, the similarity of igneous sections at Site U1347 with that cored on Ontong Java Plateau implies similar volcanic styles for these two plateaus. On younger, smaller Shatsky Rise volcanoes, pillow flows are common and massive flows thinner andfewer, which might mean volcanism waned with time. Cored sediments from summit sites contain fossils and structures implying shallow water depths or emergence at the time of eruption and normal subsidence since. Summit sites also show pervasive alteration that could be due to high fluid fluxes. A thick section of volcaniclastics cored on Tamu Massif suggests that shallow, explosive submarine volcanism played a significant role in the geologic development of the plateau summit. Expedition 324 results imply that Shatsky Risebegan with massive eruptions forming a huge volcano and that subsequent eruptions waned in intensity, forming volcanoes that are large, but which did not erupt with unusually high effusionrates. Similarities of cored sections on Tamu Massif with those ofOntong Java Plateau indicate that these oceanic plateaus formed insimilar fashion.

  12. Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development

    Beucher, Anthony; Martín, Mercè; Spenle, Caroline; Poulet, Martine; Collin, Caitlin; Gradwohl, Gérard

    2011-01-01

    During mouse pancreas development, the transient expression of Neurogenin3 (Neurog3) in uncommitted pancreas progenitors is required to determine endocrine destiny. However it has been reported that Neurog3-expressing cells can eventually adopt acinar or ductal fates and that Neurog3 levels were important to secure the islet destiny. It is not known whether the competence of Neurog3-induced cells to give rise to non-endocrine lineages is an intrinsic property of these progenitors or depends o...

  13. On the merging rates of envelope-deprived components of binary systems which can give rise to supernova events

    Tornambe, Amedo

    1989-01-01

    We derive theoretical rates of mergings of envelope-deprived components of binary systems, which can give rise to supernova events. The effects of the various assumptions one is forced to make on the physical properties of the progenitor system and of its evolutionary behaviour through common envelope phases are discussed. Four cases have been analysed: CO-CO, He-CO, He-He double degenerate mergings and He star-CO dwarf merging. (author)

  14. Migrating glioma cells express stem cell markers and give rise to new tumors upon xenografting

    Munthe, Sune; Sørensen, Mia D; Thomassen, Mads

    2016-01-01

    Glioblastoma (GBM) is the most frequent and malignant brain tumor with an overall survival of only 14.6 months. Although these tumors are treated with surgery, radiation and chemotherapy, recurrence is inevitable. A critical population of tumor cells in terms of therapy, the so-called cancer stem......-like phenotype is currently lacking. In the present study, the aim was to characterize the phenotype of migrating tumor cells using a novel migration assay based on serum-free stem cell medium and patient-derived spheroid cultures. The results showed pronounced migration of five different GBM spheroid cultures......-related genes and the HOX-gene list in migrating cells compared to spheroids. Determination of GBM molecular subtypes revealed that subtypes of spheroids and migrating cells were identical. In conclusion, migrating tumor cells preserve expression of stem cell markers and functional CSC characteristics. Since...

  15. Evaluation gives productivity and quality gives fruit in Aguacate subjected has to gamma radiation

    De La Cruz Torres, Eulogio; Garcia Andrade, Juan M.; Ibannez Palacios, Jorge; Mijares Oviedo, Pedro

    1999-01-01

    Evaluation of productivity, post harvest behavior and fruit quality was performed on four years Has avocado trees irradiated with 60 Co gamma rays in doses of 5, 10, 15, 20 and 25 Gy, established in the La Labor Experimental Center of the Centro de Investigaciones Cientificas y Tecnologicas del Aguacate en el Estado de Mexico (CICTAMEX) at Temascaltepec Mexico. Productivity had a significant increase in the dose of 15 Gy being the average number of fruits nearly 400 % more than the control at fruit setting, being such difference reduced at fruit harvesting to 300%. In regard to post harvest performance, the respiration index (mg CO2 /kg/hr) did not show significant differences among treatments. Also others variables such as physiological weight losses, texture, maturity pattern, and sensorial tests (color, flavor, aroma, texture) were not different in regard to the control. This means that radiation has altered productivity but not the quality and post harvest behavior of fruits

  16. Histone H1- and other protein- and amino acid-hydroperoxides can give rise to free radicals which oxidize DNA

    Luxford, C; Morin, B; Dean, R T

    1999-01-01

    analysis has demonstrated that radicals from histone H1-hydroperoxides, and other protein and amino acid hydroperoxides, can also oxidize both free 2'-deoxyguanosine and intact calf thymus DNA to give the mutagenic oxidized base 7, 8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine, 8-oxod......Exposure of amino acids, peptides and proteins to radicals, in the presence of oxygen, gives high yields of hydroperoxides. These materials are readily decomposed by transition metal ions to give further radicals. We hypothesized that hydroperoxide formation on nuclear proteins, and subsequent...... decomposition of these hydroperoxides to radicals, might result in oxidative damage to associated DNA. We demonstrate here that exposure of histone H1 and model compounds to gamma-radiation in the presence of oxygen gives hydroperoxides in a dose-dependent manner. These hydroperoxides decompose to oxygen...

  17. Stem/progenitor cells derived from the cochlear sensory epithelium give rise to spheres with distinct morphologies and features.

    Diensthuber, Marc; Oshima, Kazuo; Heller, Stefan

    2009-06-01

    Nonmammalian vertebrates regenerate lost sensory hair cells by means of asymmetric division of supporting cells. Inner ear or lateral line supporting cells in birds, amphibians, and fish consequently serve as bona fide stem cells resulting in high regenerative capacity of hair cell-bearing organs. Hair cell regeneration does not happen in the mammalian cochlea, but cells with proliferative capacity can be isolated from the neonatal cochlea. These cells have the ability to form clonal floating colonies, so-called spheres, when cultured in nonadherent conditions. We noticed that the sphere population derived from mouse cochlear sensory epithelium cells was heterogeneous, consisting of morphologically distinct sphere types, hereby classified as solid, transitional, and hollow. Cochlear sensory epithelium-derived stem/progenitor cells initially give rise to small solid spheres, which subsequently transition into hollow spheres, a change that is accompanied by epithelial differentiation of the majority of sphere cells. Only solid spheres, and to a lesser extent, transitional spheres, appeared to harbor self-renewing stem cells, whereas hollow spheres could not be consistently propagated. Solid spheres contained significantly more rapidly cycling Pax-2-expressing presumptive otic progenitor cells than hollow spheres. Islet-1, which becomes upregulated in nascent sensory patches, was also more abundant in solid than in hollow spheres. Likewise, hair cell-like cells, characterized by the expression of multiple hair cell markers, differentiated in significantly higher numbers in cell populations derived from solid spheres. We conclude that cochlear sensory epithelium cell populations initially give rise to small solid spheres that have self-renewing capacity before they subsequently convert into hollow spheres, a process that is accompanied by loss of stemness and reduced ability to spontaneously give rise to hair cell-like cells. Solid spheres might, therefore, represent

  18. Synchrotron radiation gives insight in smaller and smaller crystals

    Hintsches, E.

    1983-01-01

    Scientists from the ''Max-Planck-Institut fuer Festkoerperforschung'' in Stuttgart have extended the method of X-ray analysis to study the structure of very small crystals. For the first time a crystal with 6 μm linear dimension has been successfully analysed using the synchrotron radiation from the DESY electron synchrotron at Hamburg. Thus this important method of analysis has been demonstrated to be usefull for structural studies of crystals, which are smaller by a factor of 20 than hitherto. (orig.) [de

  19. On the merging rates of envelope-deprived components of binary systems which can give rise to supernova events

    Tornambe, Amedeo

    1989-08-01

    Theoretical rates of mergings of envelope-deprived components of binary systems, which can give rise to supernova events are described. The effects of the various assumptions on the physical properties of the progenitor system and of its evolutionary behavior through common envelope phases are discussed. Four cases have been analyzed: CO-CO, He-CO, He-He double degenerate mergings and He star-CO dwarf merging. It is found that, above a critical efficiency of the common envelope action in system shrinkage, the rate of CO-CO mergings is not strongly sensitive to the efficiency. Below this critical value, no CO-CO systems will survive for times larger than a few Gyr. In contrast, He-CO dwarf systems will continue to merge at a reasonable rate up to 20 Gyr, and more, also under extreme conditions.

  20. Pox neuro control of cell lineages that give rise to larval poly-innervated external sensory organs in Drosophila.

    Jiang, Yanrui; Boll, Werner; Noll, Markus

    2015-01-15

    The Pox neuro (Poxn) gene of Drosophila plays a crucial role in the development of poly-innervated external sensory (p-es) organs. However, how Poxn exerts this role has remained elusive. In this study, we have analyzed the cell lineages of all larval p-es organs, namely of the kölbchen, papilla 6, and hair 3. Surprisingly, these lineages are distinct from any previously reported cell lineages of sensory organs. Unlike the well-established lineage of mono-innervated external sensory (m-es) organs and a previously proposed model of the p-es lineage, we demonstrate that all wild-type p-es lineages exhibit the following features: the secondary precursor, pIIa, gives rise to all three support cells-socket, shaft, and sheath, whereas the other secondary precursor, pIIb, is neuronal and gives rise to all neurons. We further show that in one of the p-es lineages, that of papilla 6, one cell undergoes apoptosis. By contrast in Poxn null mutants, all p-es lineages have a reduced number of cells and their pattern of cell divisions is changed to that of an m-es organ, with the exception of a lineage in a minority of mutant kölbchen that retains a second bipolar neuron. Indeed, the role of Poxn in p-es lineages is consistent with the specification of the developmental potential of secondary precursors and the regulation of cell division but not apoptosis. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. Contribution gives the cosmic radiation to the doses for exhibition to the natural radiation in the Cuban population

    Tomas Zerquera, J.; Peres Sanchez, D.; Prendes Alonso, M

    1998-01-01

    With the objective to specify the preponderant contribution the cosmic component the radiation in the dose that the Cuban population receives you carries out a program she gives mensurations she gives this component in the whole country

  2. Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development.

    Beucher, Anthony; Martín, Mercè; Spenle, Caroline; Poulet, Martine; Collin, Caitlin; Gradwohl, Gérard

    2012-01-15

    During mouse pancreas development, the transient expression of Neurogenin3 (Neurog3) in uncommitted pancreas progenitors is required to determine endocrine destiny. However it has been reported that Neurog3-expressing cells can eventually adopt acinar or ductal fates and that Neurog3 levels were important to secure the islet destiny. It is not known whether the competence of Neurog3-induced cells to give rise to non-endocrine lineages is an intrinsic property of these progenitors or depends on pancreas developmental stage. Using temporal genetic labeling approaches we examined the dynamic of endocrine progenitor differentiation and explored the plasticity of Neurog3-induced cells throughout development. We found that Neurog3(+) progenitors develop into hormone-expressing cells in a fast process taking less then 10h. Furthermore, fate-mapping studies in heterozygote (Neurog3(CreERT/+)) and Neurog3-deficient (Neurog3(CreERT/CreERT)) embryos revealed that Neurog3-induced cells have different potential over time. At the early bud stage, failed endocrine progenitors can adopt acinar or ductal fate, whereas later in the branching pancreas they do not contribute to the acinar lineage but Neurog3-deficient cells eventually differentiate into duct cells. Thus these results provide evidence that the plasticity of Neurog3-induced cells becomes restricted during development. Furthermore these data suggest that during the secondary transition, endocrine progenitor cells arise from bipotent precursors already committed to the duct/endocrine lineages and not from domain of cells having distinct potentialities. Copyright © 2011 Elsevier Inc. All rights reserved.

  3. Muscle-derived stem cells isolated as non-adherent population give rise to cardiac, skeletal muscle and neural lineages.

    Arsic, Nikola; Mamaeva, Daria; Lamb, Ned J; Fernandez, Anne

    2008-04-01

    Stem cells with the ability to differentiate in specialized cell types can be extracted from a wide array of adult tissues including skeletal muscle. Here we have analyzed a population of cells isolated from skeletal muscle on the basis of their poor adherence on uncoated or collagen-coated dishes that show multi-lineage differentiation in vitro. When analysed under proliferative conditions, these cells express stem cell surface markers Sca-1 (65%) and Bcrp-1 (80%) but also MyoD (15%), Neuronal beta III-tubulin (25%), GFAP (30%) or Nkx2.5 (1%). Although capable of growing as non-attached spheres for months, when given an appropriate matrix, these cells adhere giving rise to skeletal muscle, neuronal and cardiac muscle cell lineages. A similar cell population could not be isolated from either bone marrow or cardiac tissue suggesting their specificity to skeletal muscle. When injected into damaged muscle, these non-adherent muscle-derived cells are retrieved expressing Pax7, in a sublaminar position characterizing satellite cells and participate in forming new myofibers. These data show that a non-adherent stem cell population can be specifically isolated and expanded from skeletal muscle and upon attachment to a matrix spontaneously differentiate into muscle, cardiac and neuronal lineages in vitro. Although competing with resident satellite cells, these cells are shown to significantly contribute to repair of injured muscle in vivo supporting that a similar muscle-derived non-adherent cell population from human muscle may be useful in treatment of neuromuscular disorders.

  4. Muscle-derived stem cells isolated as non-adherent population give rise to cardiac, skeletal muscle and neural lineages

    Arsic, Nikola; Mamaeva, Daria; Lamb, Ned J.; Fernandez, Anne

    2008-01-01

    Stem cells with the ability to differentiate in specialized cell types can be extracted from a wide array of adult tissues including skeletal muscle. Here we have analyzed a population of cells isolated from skeletal muscle on the basis of their poor adherence on uncoated or collagen-coated dishes that show multi-lineage differentiation in vitro. When analysed under proliferative conditions, these cells express stem cell surface markers Sca-1 (65%) and Bcrp-1 (80%) but also MyoD (15%), Neuronal β III-tubulin (25%), GFAP (30%) or Nkx2.5 (1%). Although capable of growing as non-attached spheres for months, when given an appropriate matrix, these cells adhere giving rise to skeletal muscle, neuronal and cardiac muscle cell lineages. A similar cell population could not be isolated from either bone marrow or cardiac tissue suggesting their specificity to skeletal muscle. When injected into damaged muscle, these non-adherent muscle-derived cells are retrieved expressing Pax7, in a sublaminar position characterizing satellite cells and participate in forming new myofibers. These data show that a non-adherent stem cell population can be specifically isolated and expanded from skeletal muscle and upon attachment to a matrix spontaneously differentiate into muscle, cardiac and neuronal lineages in vitro. Although competing with resident satellite cells, these cells are shown to significantly contribute to repair of injured muscle in vivo supporting that a similar muscle-derived non-adherent cell population from human muscle may be useful in treatment of neuromuscular disorders

  5. A Hebbian learning rule gives rise to mirror neurons and links them to control theoretic inverse models

    Alexander eHanuschkin

    2013-06-01

    Full Text Available Mirror neurons are neurons whose responses to the observation of a motor act resemble responses measured during production of that act. Computationally, mirror neurons have been viewed as evidence for the existence of internal inverse models. Such models, rooted within control theory, map desired sensory targets onto the motor commands required to generate those targets. To jointly explore both the formation of mirrored responses and their functional contribution to inverse models, we develop a correlation-based theory of interactions between a sensory and a motor area. We show that a simple eligibility-weighted Hebbian learning rule, operating within a sensorimotor loop during motor explorations and stabilized by heterosynaptic competition, naturally gives rise to mirror neurons as well as control theoretic inverse models encoded in the synaptic weights from sensory to motor neurons. Crucially, we find that the correlational structure or stereotypy of the neural code underlying motor explorations determines the nature of the learned inverse model: Random motor codes lead to causal inverses that map sensory activity patterns to their motor causes; such inverses are maximally useful, they allow for imitating arbitrary sensory target sequences. By contrast, stereotyped motor codes lead to less useful predictive inverses that map sensory activity to future motor actions.Our theory generalizes previous work on inverse models by showing that such models can be learned in a simple Hebbian framework without the need for error signals or backpropagation, and it makes new conceptual connections between the causal nature of inverse models, the statistical structure of motor variability, and the time-lag between sensory and motor responses of mirror neurons. Applied to bird song learning, our theory can account for puzzling aspects of the song system, including necessity of sensorimotor gating and selectivity of auditory responses to bird’s own song

  6. A Hebbian learning rule gives rise to mirror neurons and links them to control theoretic inverse models.

    Hanuschkin, A; Ganguli, S; Hahnloser, R H R

    2013-01-01

    Mirror neurons are neurons whose responses to the observation of a motor act resemble responses measured during production of that act. Computationally, mirror neurons have been viewed as evidence for the existence of internal inverse models. Such models, rooted within control theory, map-desired sensory targets onto the motor commands required to generate those targets. To jointly explore both the formation of mirrored responses and their functional contribution to inverse models, we develop a correlation-based theory of interactions between a sensory and a motor area. We show that a simple eligibility-weighted Hebbian learning rule, operating within a sensorimotor loop during motor explorations and stabilized by heterosynaptic competition, naturally gives rise to mirror neurons as well as control theoretic inverse models encoded in the synaptic weights from sensory to motor neurons. Crucially, we find that the correlational structure or stereotypy of the neural code underlying motor explorations determines the nature of the learned inverse model: random motor codes lead to causal inverses that map sensory activity patterns to their motor causes; such inverses are maximally useful, by allowing the imitation of arbitrary sensory target sequences. By contrast, stereotyped motor codes lead to less useful predictive inverses that map sensory activity to future motor actions. Our theory generalizes previous work on inverse models by showing that such models can be learned in a simple Hebbian framework without the need for error signals or backpropagation, and it makes new conceptual connections between the causal nature of inverse models, the statistical structure of motor variability, and the time-lag between sensory and motor responses of mirror neurons. Applied to bird song learning, our theory can account for puzzling aspects of the song system, including necessity of sensorimotor gating and selectivity of auditory responses to bird's own song (BOS) stimuli.

  7. Postnatal Sonic hedgehog (Shh) responsive cells give rise to oligodendrocyte lineage cells during myelination and in adulthood contribute to remyelination.

    Sanchez, Maria A; Armstrong, Regina C

    2018-01-01

    Sonic hedgehog (Shh) regulates a wave of oligodendrocyte production for extensive myelination during postnatal development. During this postnatal period of oligodendrogenesis, we fate-labeled cells exhibiting active Shh signaling to examine their contribution to the regenerative response during remyelination. Bitransgenic mouse lines were generated for induced genetic fate-labeling of cells actively transcribing Shh or Gli1. Gli1 transcription is an effective readout for canonical Shh signaling. Shh CreERT2 mice and Gli1 CreERT2 mice were crossed to either R26 tdTomato mice to label cells with red fluorescence, or, R26 IAP mice to label membranes with alkaline phosphatase. When tamoxifen (TMX) was given on postnatal days 6-9 (P6-9), Shh ligand synthesis was prevalent in neurons of Shh CreERT2 ; R26 tdTomato mice and Shh CreERT2 ;R26 IAP mice. In Gli1 CreERT2 crosses, TMX from P6-9 detected Gli1 transcription in cells that populated the corpus callosum (CC) during postnatal myelination. Delaying TMX to P14-17, after the peak of oligodendrogenesis, significantly reduced labeling of Shh synthesizing neurons and Gli1 expressing cells in the CC. Importantly, Gli1 CreERT2 ;R26 tdTomato mice given TMX from P6-9 showed Gli1 fate-labeled cells in the adult (P56) CC, including cycling progenitor cells identified by EdU incorporation and NG2 immunolabeling. Furthermore, after cuprizone demyelination of the adult CC, Gli1 fate-labeled cells incorporated EdU and were immunolabeled by NG2 early during remyelination while forming myelin-like membranes after longer periods for remyelination to progress. These studies reveal a postnatal cell population with transient Shh signaling that contributes to oligodendrogenesis during CC myelination, and gives rise to cells that continue to proliferate in adulthood and contribute to CC remyelination. Published by Elsevier Inc.

  8. Differential receptive field organizations give rise to nearly identical neural correlations across three parallel sensory maps in weakly electric fish.

    Hofmann, Volker; Chacron, Maurice J

    2017-09-01

    Understanding how neural populations encode sensory information thereby leading to perception and behavior (i.e., the neural code) remains an important problem in neuroscience. When investigating the neural code, one must take into account the fact that neural activities are not independent but are actually correlated with one another. Such correlations are seen ubiquitously and have a strong impact on neural coding. Here we investigated how differences in the antagonistic center-surround receptive field (RF) organization across three parallel sensory maps influence correlations between the activities of electrosensory pyramidal neurons. Using a model based on known anatomical differences in receptive field center size and overlap, we initially predicted large differences in correlated activity across the maps. However, in vivo electrophysiological recordings showed that, contrary to modeling predictions, electrosensory pyramidal neurons across all three segments displayed nearly identical correlations. To explain this surprising result, we incorporated the effects of RF surround in our model. By systematically varying both the RF surround gain and size relative to that of the RF center, we found that multiple RF structures gave rise to similar levels of correlation. In particular, incorporating known physiological differences in RF structure between the three maps in our model gave rise to similar levels of correlation. Our results show that RF center overlap alone does not determine correlations which has important implications for understanding how RF structure influences correlated neural activity.

  9. Conditions giving rise to intense visible room temperature photoluminescence in SrWO4 thin films: the role of disorder

    Orhan, E.; Anicete-Santos, M.; Maurera, M.A.M.A.; Pontes, F.M.; Paiva-Santos, C.O.; Souza, A.G.; Varela, J.A.; Pizani, P.S.; Longo, E.

    2005-01-01

    The nature of intense visible photoluminescence at room temperature of SrWO 4 (SWO) non-crystalline thin films is discussed in the light of experimental results and theoretical calculations. The SWO thin films were synthesized by the polymeric precursors method. Their structural properties have been obtained by X-ray diffraction data and the corresponding photoluminescence (PL) spectra have been measured. The UV-vis optical spectra measurements suggest the creation of localized states in the disordered structure. The photoluminescence measurements reveal that the PL changes with the degree of disorder in the SWO thin film. To understand the origin of visible PL at room temperature in disordered SWO, we performed quantum-mechanical calculations on crystalline and disordered SWO periodic models. Their electronic structures are analyzed in terms of DOS, band dispersion and charge densities. We used DFT method with the hybrid non-local B3LYP approximation. The polarization induced by the symmetry break and the existence of localized levels favors the creation of trapped holes and electrons, giving origin to the room temperature photoluminescence phenomenon in the SWO thin films

  10. How thoughts give rise to action - conscious motor intention increases the excitability of target-specific motor circuits.

    Volker R Zschorlich

    Full Text Available The present study shows evidence for conscious motor intention in motor preparation prior to movement execution. We demonstrate that conscious motor intention of directed movement, combined with minimally supra-threshold transcranial magnetic stimulation (TMS of the motor cortex, determines the direction and the force of resulting movements, whilst a lack of intention results in weak and omni-directed muscle activation. We investigated changes of consciously intended goal directed movements by analyzing amplitudes of motor-evoked potentials of the forearm muscle, flexor carpi radialis (FCR, and extensor carpi radialis (ECR, induced by transcranial magnetic stimulation over the right motor cortex and their motor outcome. Right-handed subjects were asked to develop a strong intention to move their left wrist (flexion or extension, without any overt motor output at the wrist, prior to brain stimulation. Our analyses of hand acceleration and electromyography showed that during the strong motor intention of wrist flexion movement, it evoked motor potential responses that were significantly larger in the FCR muscle than in the ECR, whilst the opposite was true for an extension movement. The acceleration data on flexion/extension corresponded to this finding. Under no-intention conditions again, which served as a reference for motor evoked potentials, brain stimulation resulted in undirected and minimally simultaneous extension/flexion innervation and virtually no movement. These results indicate that conscious intentions govern motor function, which in turn shows that a neuronal activation representing an "intention network" in the human brain pre-exists, and that it functionally represents target specific motor circuits. Until today, it was unclear whether conscious motor intention exists prior to movement, or whether the brain constructs such an intention after movement initiation. Our study gives evidence that motor intentions become aware before

  11. How Thoughts Give Rise to Action - Conscious Motor Intention Increases the Excitability of Target-Specific Motor Circuits

    Zschorlich, Volker R.; Köhling, Rüdiger

    2013-01-01

    The present study shows evidence for conscious motor intention in motor preparation prior to movement execution. We demonstrate that conscious motor intention of directed movement, combined with minimally supra-threshold transcranial magnetic stimulation (TMS) of the motor cortex, determines the direction and the force of resulting movements, whilst a lack of intention results in weak and omni-directed muscle activation. We investigated changes of consciously intended goal directed movements by analyzing amplitudes of motor-evoked potentials of the forearm muscle, flexor carpi radialis (FCR), and extensor carpi radialis (ECR), induced by transcranial magnetic stimulation over the right motor cortex and their motor outcome. Right-handed subjects were asked to develop a strong intention to move their left wrist (flexion or extension), without any overt motor output at the wrist, prior to brain stimulation. Our analyses of hand acceleration and electromyography showed that during the strong motor intention of wrist flexion movement, it evoked motor potential responses that were significantly larger in the FCR muscle than in the ECR, whilst the opposite was true for an extension movement. The acceleration data on flexion/extension corresponded to this finding. Under no-intention conditions again, which served as a reference for motor evoked potentials, brain stimulation resulted in undirected and minimally simultaneous extension/flexion innervation and virtually no movement. These results indicate that conscious intentions govern motor function, which in turn shows that a neuronal activation representing an “intention network” in the human brain pre-exists, and that it functionally represents target specific motor circuits. Until today, it was unclear whether conscious motor intention exists prior to movement, or whether the brain constructs such an intention after movement initiation. Our study gives evidence that motor intentions become aware before any motor

  12. Temperature rise, sea level rise and increased radiative forcing - an application of cointegration methods

    Schmith, Torben; Thejll, Peter; Johansen, Søren

    2016-04-01

    We analyse the statistical relationship between changes in global temperature, global steric sea level and radiative forcing in order to reveal causal relationships. There are in this, however, potential pitfalls due to the trending nature of the time series. We therefore apply a statistical method called cointegration analysis, originating from the field of econometrics, which is able to correctly handle the analysis of series with trends and other long-range dependencies. Further, we find a relationship between steric sea level and temperature and find that temperature causally depends on the steric sea level, which can be understood as a consequence of the large heat capacity of the ocean. This result is obtained both when analyzing observed data and data from a CMIP5 historical model run. Finally, we find that in the data from the historical run, the steric sea level, in turn, is driven by the external forcing. Finally, we demonstrate that combining these two results can lead to a novel estimate of radiative forcing back in time based on observations.

  13. Glycation of low-density lipoproteins by methylglyoxal and glycolaldehyde gives rise to the in vitro formation of lipid-laden cells

    Brown, B E; Dean, R T; Davies, Michael Jonathan

    2005-01-01

    AIMS/HYPOTHESIS: Previous studies have implicated the glycoxidative modification of low-density lipoprotein (LDL) by glucose and aldehydes (apparently comprising both glycation and oxidation), as a causative factor in the elevated levels of atherosclerosis observed in diabetic patients. Such LDL...... or endothelial cells. The extent of lipid accumulation depends on the degree of glycation, with increasing aldehyde concentration or incubation time, giving rise to greater extents of particle modification and lipid accumulation. Modification of lysine residues appears to be a key determinant of cellular uptake...

  14. Beta-scission of alkoxyl radicals on peptides and proteins can give rise to backbone cleavage and loss of side-chains

    Headlam, H.A.; Davies, M.J.; Mortimer, A.; Easton, C.J.

    2000-01-01

    Full text: Exposure of proteins to radicals in the presence of O 2 brings about multiple changes including side-chain oxidation, backbone fragmentation, cross-linking, unfolding, changes in hydrophobicity and conformation, altered susceptibility to proteolytic enzymes and formation of new reactive groups (e.g. hydroperoxides and 3,4-dihydroxyphenylalanine). All of these processes can result in loss of structural or enzymatic activity. The mechanisms that give rise to backbone cleavage are only partly understood. Whilst it is known that direct hydrogen atom abstraction at a-carbon sites gives backbone cleavages it has also been proposed that initial attack at side-chain sites might also give rise to backbone cleavage. In this study we have examined whether initial attack at the β- (C-3) position can give rise to α-carbon radicals (and hence backbone cleavage) via the formation, and subsequent β- scission, of C-3 alkoxyl radicals. This process has been observed previously with protected amino acids in organic solvents (J. Chem. Soc. Perkin Trans. 2, 1997, 503-507) but the occurrence of such reactions with proteins in aqueous solution has not been explored. Alkoxyl radicals were generated at the C-3 position of a variety of protected amino acids and small peptides by two methods: metal-ion catalysed decomposition of hydroperoxides formed as a result of γ-radiolysis in the presence of O 2 , and UV photolysis of nitrate esters. In most cases radicals have been detected by EPR spectroscopy using nitroso and nitrone spin traps, which can be assigned by comparison with literature data to α-carbon radicals; in some case assignments were confirmed by the generation of the putative species by other routes. With Ala peptide hydroperoxides and nitrate esters, and MNP as the spin trap, the major radical detected in each case has been assigned to the adduct of an α-carbon radical with partial structure - NH- . CH-C(O) - consistent with the rapid occurrence of the above

  15. Radiation monitoring for the HTTR rise-to-power test (1) and (2)'

    Nakazawa, Takashi; Yoshino, Toshiaki; Yasu, Katsuji; Ashikagaya, Yoshinobu; Kikuchi, Toshiki [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment

    2001-02-01

    The High Temperature Engineering Test Reactor (HTTR) is the first high temperature gas-cooled research reactor in Japan. This reactor is a helium-gas-cooled and graphite-moderated reactor with a thermal output of 30 MW. The rated operation temperature of the outlet coolant is 850degC. (During high temperature test operation, this reaches 950degC). The first criticality of the HTTR was attained in November 1998. The single loaded, parallel loaded operation with a thermal output of 9 MW (called the HTTR Rise-to-Power Test (1)) was completed between September 16, 1999 and July 8, 2000. The single loaded, parallel loaded continuous operation with a thermal output of 20 MW (called the HTTR Rise-to-Power Test (2)) has also been carried out, but it was shutdown at the halfway stage by a single from the reactor, when the thermal output was 16.5 MW and the reactor outlet coolant temperature was 500degC. This report describes the radiation monitoring carried out during the HTTR Rise-to-Power Tests (1) and (2)'. The data measured by the various radiation monitors is also reported. These data will be used for the estimation of radiation levels (such as the radiation dose equivalent rate, the radioactive concentration in effluents, etc.) for the next HTTR Rise-to-Power Test, and for periodic inspections. (author)

  16. Very low temperature rise laser annealing of radiation-damaged solar cells in orbit

    Poulek, V.

    1988-01-01

    Solar cells of all space objects are damaged by radiation in orbit. This damage, however, can be removed by laser annealing. A new in-orbit laser regeneration system for both body- and spin-stabilized space objects is proposed. For successful annealing of solar cells damaged by 10 years' radiation dose in orbit it is necessary for the temperature rise in the incidence point of the laser beam to reach about 400 0 C. By continuous regeneration, however, between two annealing cycles the solar cells are hit by about two orders of magnitude lower radiation dose. This makes it possible to carry out the regeneration at a temperature rise well under 1 0 C! If an optimal laser regeneration system is used, such low temperature rise laser annealing of radiation-damaged solar cells is possible. A semiconductor GaAlAs diode laser with output power up to 10 mW CW was used for annealing. Some results of the very low temperature rise annealing experiment are given in this paper. (author)

  17. A Set of Regioselective O-Methyltransferases Gives Rise to the Complex Pattern of Methoxylated Flavones in Sweet Basil1[C][W][OA

    Berim, Anna; Hyatt, David C.; Gang, David R.

    2012-01-01

    Polymethoxylated flavonoids occur in a number of plant families, including the Lamiaceae. To date, the metabolic pathways giving rise to the diversity of these compounds have not been studied. Analysis of our expressed sequence tag database for four sweet basil (Ocimum basilicum) lines afforded identification of candidate flavonoid O-methyltransferase genes. Recombinant proteins displayed distinct substrate preferences and product specificities that can account for all detected 7-/6-/4′-methylated, 8-unsubstituted flavones. Their biochemical specialization revealed only certain metabolic routes to be highly favorable and therefore likely in vivo. Flavonoid O-methyltransferases catalyzing 4′- and 6-O-methylations shared high identity (approximately 90%), indicating that subtle sequence changes led to functional differentiation. Structure homology modeling suggested the involvement of several amino acid residues in defining the proteins’ stringent regioselectivities. The roles of these individual residues were confirmed by site-directed mutagenesis, revealing two discrete mechanisms as a basis for the switch between 6- and 4′-O-methylation of two different substrates. These findings delineate major pathways in a large segment of the flavone metabolic network and provide a foundation for its further elucidation. PMID:22923679

  18. Local infection of opium poppy leaves by Peronospora somniferi sporangia can give rise to systemic infections and seed infection in resistant cultivars

    Montes-Borrego, M.; Muñoz-Ledesma, F.J.; Jiménez-Díaz, R.M.; Landa, B.B.

    2017-07-01

    Downy mildew (DM) of opium poppy (Papaver somniferum) caused by Peronospora somniferi is one of the most destructive diseases of this crop due to the systemic nature of infection as compared with local infections caused by Peronospora meconopsidis, the other downy mildew pathogen of this crop. We developed an inoculation method using Peronospora somniferi sporangia as inoculum and demonstrated for the first time that local infection of leaves by sporangia give rise to systemic infections in the plant as well as of seeds. Our results also showed that this inoculation protocol was very effective in reproducing disease symptoms and assessing the resistance response to DM in opium poppy genotypes under field conditions. More interestingly, results indicate that up to 100% of seed samples from some genotypes showing a complete (symptomless) resistant phenotype were infected by the pathogen when seeds were analyzed by a P. somniferi-specific nested-PCR protocol. This latter aspect deserves further attention while breeding opium poppy for resistance to P. somniferi.

  19. Local infection of opium poppy leaves by Peronospora somniferi sporangia can give rise to systemic infections and seed infection in resistant cultivars

    Montes-Borrego, M.; Muñoz-Ledesma, F.J.; Jiménez-Díaz, R.M.; Landa, B.B.

    2017-01-01

    Downy mildew (DM) of opium poppy (Papaver somniferum) caused by Peronospora somniferi is one of the most destructive diseases of this crop due to the systemic nature of infection as compared with local infections caused by Peronospora meconopsidis, the other downy mildew pathogen of this crop. We developed an inoculation method using Peronospora somniferi sporangia as inoculum and demonstrated for the first time that local infection of leaves by sporangia give rise to systemic infections in the plant as well as of seeds. Our results also showed that this inoculation protocol was very effective in reproducing disease symptoms and assessing the resistance response to DM in opium poppy genotypes under field conditions. More interestingly, results indicate that up to 100% of seed samples from some genotypes showing a complete (symptomless) resistant phenotype were infected by the pathogen when seeds were analyzed by a P. somniferi-specific nested-PCR protocol. This latter aspect deserves further attention while breeding opium poppy for resistance to P. somniferi.

  20. New way to rise estimation objectivity of radiation consequences on human

    Akhmatullina, N. B.

    2001-01-01

    The discussion of negative consequences of radiation on human often leaves without attention the fact that the basic meaning of danger of radiation level rise in environment for human connected with genetic structure defects. Namely changes in genome lead to different negative consequences and not only accompany, but also precede them. However the tendency which appeared in our country to substitute the direct genetic analysis with references to rise of frequency of morbidity on separate nosologic groups, whose area is widen arbitrary, has brought to nonadequateness of methodologic approach, distorted the determination of 'genetic consequence' itself and as the effect of this, distorted the real estimation of consequences of Kazakh Test Sites (TS) and other sources of radiation contamination activity. The question is arising: how can we distinguish observed and discribed effects of other genotoxicants of chemical and biological origin? There are different cytogenetic methods to detect genetic damages. The more widely used - is the estimation of the chromosome anomalies frequency estimation in somatic cells, especially in lymphocytes of peripheral blood. Traditionally researches proceeds from thin mechanisms of mutagenesis, which points that radiation mutagenesis leads primarily to chromosome, and chemical - to chromatide aberrations. In radiation influence chromosome aberrations appears in nondivided lymphocytes (G1-phase) and became easily observed in first metaphase (Browen e.a.1972, Bender e.a.1966). On the contrary the aberrations, induced by chemical factors, appears primarily in the S- phase irrespectively of what is cycle's stage, when the cells were exposed. Therefore the majority of aberrations have chromatide type (Evanse e.a.1980, Preston e.a.1981). Following pointed criteria many original investigations on people exposed to radiation were carried out. Moreover it was proved the application of such method to estimate the absorbed radiation in the

  1. Can molluscan assemblages give insights into Holocene environmental changes other than sea level rise? A case study from a macrotidal bay (Marennes-Oleron, France)

    Poirier, Clement; Sauriau, Pierre-guy; Chaumillon, Eric; Allard, Jonathan

    2009-01-01

    During the Late Holocene, the rate of sea level rise decreased and climate changes, hydrodynamic processes or anthropogenic impacts became predominant parameters governing the sedimentary infill of estuarine environments. The aim of this study is to describe the response of past benthic mollusc communities to these forcing factors. Mollusc skeletal remains were sampled from three 8000, 5500 and 2600 year-long sedimentary records in the Marennes-Oleron Bay (Atlantic Coast, France), where envir...

  2. Evaluation gives productivity and quality gives fruit in Aguacate subjected has to gamma radiation; Evaluacion de productividad y calidad de fruta en aguacate hass sometido a radiacion gamma

    De La Cruz Torres, Eulogio; Garcia Andrade, Juan M [Instituto Nacional de Investigaciones Nucleares. Mexico D.F. (Mexico); Ibannez Palacios, Jorge [Facultad de Ciencias Agricolas. U.A.E., Toluca (Mexico); Mijares Oviedo, Pedro [Fundacion Salvador Sanchez Col CICTAMEX, Coatepec Harina (Mexico)

    1999-07-01

    Evaluation of productivity, post harvest behavior and fruit quality was performed on four years Has avocado trees irradiated with 60 Co gamma rays in doses of 5, 10, 15, 20 and 25 Gy, established in the La Labor Experimental Center of the Centro de Investigaciones Cientificas y Tecnologicas del Aguacate en el Estado de Mexico (CICTAMEX) at Temascaltepec Mexico. Productivity had a significant increase in the dose of 15 Gy being the average number of fruits nearly 400 % more than the control at fruit setting, being such difference reduced at fruit harvesting to 300%. In regard to post harvest performance, the respiration index (mg CO2 /kg/hr) did not show significant differences among treatments. Also others variables such as physiological weight losses, texture, maturity pattern, and sensorial tests (color, flavor, aroma, texture) were not different in regard to the control. This means that radiation has altered productivity but not the quality and post harvest behavior of fruits.

  3. Giving presentations

    Ellis, Mark

    1997-01-01

    This is part of a series of books, which gives training in key business communication skills. Emphasis is placed on building awareness of language appropriateness and fluency in typical business interactions. This new edition is in full colour.

  4. Devonian rise in atmospheric oxygen correlated to the radiations of terrestrial plants and large predatory fish

    Dahl, Tais Wittchen; Hammarlund, Emma; Anbar, Ariel D.

    2010-01-01

    after the initial rise of animals and, therefore, suggesting that early metazoans evolved in a relatively low oxygen environment. This later oxygenation correlates with the diversification of vascular plants, which likely contributed to increased oxygenation through the enhanced burial of organic carbon...

  5. Radiofrequency radiation from nearby base stations gives high levels in an apartment in Stockholm, Sweden: A case report

    Hardell, Lennart; Carlberg, Michael; Hedendahl, Lena K.

    2018-01-01

    Exposure to radiofrequency (RF) radiation was classified in 2011 as a possible human carcinogen, Group 2B, by the International Agency for Research on Cancer of the World Health Organisation. Evidence of the risk of cancer risk has since strengthened. Exposure is changing due to the rapid development of technology resulting in increased ambient radiation. RF radiation of sufficient intensity heats tissues, but the energy is insufficient to cause ionization, hence it is called non-ionizing radiation. These non-thermal exposure levels have resulted in biological effects in humans, animals and cells, including an increased cancer risk. In the present study, the levels of RF radiation were measured in an apartment close to two groups of mobile phone base stations on the roof. A total of 74,531 measurements were made corresponding to ~83 h of recording. The total mean RF radiation level was 3,811 µW/m2 (range 15.2–112,318 µW/m2) for the measurement of the whole apartment, including balconies. Particularly high levels were measured on three balconies and 3 of 4 bedrooms. The total mean RF radiation level decreased by 98% when the measured down-links from the base stations for 2, 3 and 4 G were disregarded. The results are discussed in relation to the detrimental health effects of non-thermal RF radiation. Due to the current high RF radiation, the apartment is not suitable for long-term living, particularly for children who may be more sensitive than adults. For a definitive conclusion regarding the effect of RF radiation from nearby base stations, one option would be to turn them off and repeat the measurements. However, the simplest and safest solution would be to turn them off and dismantle them. PMID:29725476

  6. Radiofrequency radiation from nearby base stations gives high levels in an apartment in Stockholm, Sweden: A case report.

    Hardell, Lennart; Carlberg, Michael; Hedendahl, Lena K

    2018-05-01

    Exposure to radiofrequency (RF) radiation was classified in 2011 as a possible human carcinogen, Group 2B, by the International Agency for Research on Cancer of the World Health Organisation. Evidence of the risk of cancer risk has since strengthened. Exposure is changing due to the rapid development of technology resulting in increased ambient radiation. RF radiation of sufficient intensity heats tissues, but the energy is insufficient to cause ionization, hence it is called non-ionizing radiation. These non-thermal exposure levels have resulted in biological effects in humans, animals and cells, including an increased cancer risk. In the present study, the levels of RF radiation were measured in an apartment close to two groups of mobile phone base stations on the roof. A total of 74,531 measurements were made corresponding to ~83 h of recording. The total mean RF radiation level was 3,811 µW/m 2 (range 15.2-112,318 µW/m 2 ) for the measurement of the whole apartment, including balconies. Particularly high levels were measured on three balconies and 3 of 4 bedrooms. The total mean RF radiation level decreased by 98% when the measured down-links from the base stations for 2, 3 and 4 G were disregarded. The results are discussed in relation to the detrimental health effects of non-thermal RF radiation. Due to the current high RF radiation, the apartment is not suitable for long-term living, particularly for children who may be more sensitive than adults. For a definitive conclusion regarding the effect of RF radiation from nearby base stations, one option would be to turn them off and repeat the measurements. However, the simplest and safest solution would be to turn them off and dismantle them.

  7. Analysis gives alterations stable chromosomic induced by the radiation in vitro the sanguine samples to well-known dose. Preliminary results obtained by means of chromosomic painting

    Prieto, M.J.; Moreno, M.; Gomez-Espi, M.; Olivares, P.; Herranz, R.

    1998-01-01

    In the University General Hospital Gregorio Marannon, once standardized the technique in situ hybridization with fluorescence by means of painting chromosomic the couples 1 and 2 you this carrying out the irradiation gives sanguine samples to well-known dose The objective these irradiations it is the elaboration in vitro a calibration chart dose effect for gamma ray. This new curve will allow to estimate dose in individuals with suspicion overexposure to ionizing radiations, solving some gives the limitations that it presents the technique classic cytogenetics

  8. Plus 90 and counting: Countries rise to the challenge of radiation safety

    2006-01-01

    Full text: Radiation science is the source of tools and technologies that help to address some of the most pressing issues of our times - human health, food and agriculture, industry, energy and environmental management. In many cases, the data and information gathered by applying radiation-based technologies simply cannot be obtained through any other means. Nor can the impressive results. Consider these figures. On average, over 25 million nuclear imaging procedures are carried out per year around the world to diagnose disease; annually, almost 10 million people benefit from radiopharmaceuticals (radioactive drugs), often in the context of cancer treatment. At the same time, advanced molecular and radioisotope techniques are being used to develop more effective measures to combat infectious diseases such as malaria, hepatitis, and tuberculosis. Techniques to fortify staple food crops provide vital nutrients to populations that have enough to eat, but lack the variety needed to be well-nourished. The ability to eliminate harmful bacteria and pests from the surface of raw produce enhances storage and transport - and opens opportunities to export markets. Radiation-based technologies, many of which have proven effective over decades of use in the developed world, now contribute to virtually every sector of society. In keeping with the underlying principles of the United Nations, the IAEA is committed to ensuring that all of its Member States have equal access to the advantages offered by these powerful tools. In return, the States must accept the responsibility for protecting the public and the environment from radiation exposure. Yet about once every other day, authorities at one of the world's busiest ports Rotterdam in The Netherlands detect radioactive material in shipments of scrap metal coming through their docks. Mostly the sources of radiation are pieces of old hospital equipment or industrial instruments that do not pose high health risks. The scrap metal

  9. A model of cardiovascular disease giving a plausible mechanism for the effect of fractionated low-dose ionizing radiation exposure.

    Mark P Little

    2009-10-01

    Full Text Available Atherosclerosis is the main cause of coronary heart disease and stroke, the two major causes of death in developed society. There is emerging evidence of excess risk of cardiovascular disease at low radiation doses in various occupationally exposed groups receiving small daily radiation doses. Assuming that they are causal, the mechanisms for effects of chronic fractionated radiation exposures on cardiovascular disease are unclear. We outline a spatial reaction-diffusion model for atherosclerosis and perform stability analysis, based wherever possible on human data. We show that a predicted consequence of multiple small radiation doses is to cause mean chemo-attractant (MCP-1 concentration to increase linearly with cumulative dose. The main driver for the increase in MCP-1 is monocyte death, and consequent reduction in MCP-1 degradation. The radiation-induced risks predicted by the model are quantitatively consistent with those observed in a number of occupationally-exposed groups. The changes in equilibrium MCP-1 concentrations with low density lipoprotein cholesterol concentration are also consistent with experimental and epidemiologic data. This proposed mechanism would be experimentally testable. If true, it also has substantive implications for radiological protection, which at present does not take cardiovascular disease into account. The Japanese A-bomb survivor data implies that cardiovascular disease and cancer mortality contribute similarly to radiogenic risk. The major uncertainty in assessing the low-dose risk of cardiovascular disease is the shape of the dose response relationship, which is unclear in the Japanese data. The analysis of the present paper suggests that linear extrapolation would be appropriate for this endpoint.

  10. Rise of radiation protection: science, medicine and technology in society, 1896--1935

    Serwer, D.P.

    1976-12-01

    The history of radiation protection before World War II is treated as a case study of interactions between science, medicine, and technology. The fundamental concerns include the following: are how medical and technical decisions with social impacts are made under conditions of uncertainty; how social pressures are brought to bear on the development of science, medicine, and technology; what it means for medicine or technology to be scientific; why professional groups seek international cooperation; and the roles various professionals and organizations play in controlling the harmful side effects of science, medicine, and technology. These questions are addressed in the specific context of protection from the biological effects of x-rays and radium in medical use

  11. Rise of radiation protection: science, medicine and technology in society, 1896--1935

    Serwer, D.P.

    1976-12-01

    The history of radiation protection before World War II is treated as a case study of interactions between science, medicine, and technology. The fundamental concerns include the following: are how medical and technical decisions with social impacts are made under conditions of uncertainty; how social pressures are brought to bear on the development of science, medicine, and technology; what it means for medicine or technology to be scientific; why professional groups seek international cooperation; and the roles various professionals and organizations play in controlling the harmful side effects of science, medicine, and technology. These questions are addressed in the specific context of protection from the biological effects of x-rays and radium in medical use.

  12. Decree of the 12. may 2004 giving the modes of monitoring the radiation quality of waters specified to human consumption

    2004-01-01

    The present decree settles the modes of radiation quality monitoring of waters specified for human consumption. It defines the radionuclides to be taken into account for the calculation of the total indicative dose. The total indicative dose corresponds to the involved efficient dose resulted from an intake during one year of every natural radionuclide, radon and its short lived daughters excepted ( specified in present annexe). The calculation of dose is made for adults on the base of a consumption of 730 liters of water by year. The coefficients of doses used to allow the dose calculation from the measured activity, expressed in SvBq -1 , are these ones taken in application of the article R.13333-10 of the code of Public Health. The alpha and beta activities, tritium and potassium activities have to be measured whatever the case. According to the results of the reference analysis and the type of installation in proximity it is proceeding to the research of other radioactive elements such 234 U, 238 U, 226 Ra, 228 Ra, 210 Po, 210 Pb, 14 C, 90 Sr, gamma emitters radionuclides in particular 60 Co, 131 I, 134 Cs, and 137 Cs and alpha emitters radionuclides in particular 238 Pu, 239 Pu, 240 Pu and 241 Am. (N.C.)

  13. Radiation

    Winther, J.F.; Ulbak, K.; Dreyer, L.; Pukkala, E.; Oesterlind, A.

    1997-01-01

    Exposure to solar and ionizing radiation increases the risk for cancer in humans. Some 5% of solar radiation is within the ultraviolet spectrum and may cause both malignant melanoma and non-melanocytic skin cancer; the latter is regarded as a benign disease and is accordingly not included in our estimation of avoidable cancers. Under the assumption that the rate of occurrence of malignant melanoma of the buttocks of both men and women and of the scalp of women would apply to all parts of the body in people completely unexposed to solar radiation, it was estimated that approximately 95% of all malignant melanomas arising in the Nordic populations around the year 2000 will be due to exposure to natural ultraviolet radiation, equivalent to an annual number of about 4700 cases, with 2100 in men and 2600 in women, or some 4% of all cancers notified. Exposure to ionizing radiation in the Nordic countries occurs at an average effective dose per capita per year of about 3 mSv (Iceland, 1.1 mSv) from natural sources, and about 1 mSv from man-made sources. While the natural sources are primarily radon in indoor air, natural radionuclides in food, cosmic radiation and gamma radiation from soil and building materials, the man-made sources are dominated by the diagnostic and therapeutic use of ionizing radiation. On the basis of measured levels of radon in Nordic dwellings and associated risk estimates for lung cancer derived from well-conducted epidemiological studies, we estimated that about 180 cases of lung cancer (1% of all lung cancer cases) per year could be avoided in the Nordic countries around the year 2000 if indoor exposure to radon were eliminated, and that an additional 720 cases (6%) could be avoided annually if either radon or tobacco smoking were eliminated. Similarly, it was estimated that the exposure of the Nordic populations to natural sources of ionizing radiation other than radon and to medical sources will each give rise to an annual total of 2120

  14. Radiation protection in the field of environmental protection

    Zhao Yamin

    2003-01-01

    The relationship of radiation protection with environmental protection, the sources that may give rise to the environmental radiation contamination, and the system of radiation protection and the fundamental principles and requirements for radiation environmental management are introduced. Some special radiation protection problems faced with in the radiation environmental management are discussed. (author)

  15. How effective is albedo modification (solar radiation management geoengineering) in preventing sea-level rise from the Greenland Ice Sheet?

    Applegate, Patrick J; Keller, Klaus

    2015-01-01

    Albedo modification (AM) is sometimes characterized as a potential means of avoiding climate threshold responses, including large-scale ice sheet mass loss. Previous work has investigated the effects of AM on total sea-level rise over the present century, as well as AM’s ability to reduce long-term (≫10 3 yr) contributions to sea-level rise from the Greenland Ice Sheet (GIS). These studies have broken new ground, but neglect important feedbacks in the GIS system, or are silent on AM’s effectiveness over the short time scales that may be most relevant for decision-making (<10 3 yr). Here, we assess AM’s ability to reduce GIS sea-level contributions over decades to centuries, using a simplified ice sheet model. We drive this model using a business-as-usual base temperature forcing scenario, as well as scenarios that reflect AM-induced temperature stabilization or temperature drawdown. Our model results suggest that (i) AM produces substantial near-term reductions in the rate of GIS-driven sea-level rise. However, (ii) sea-level rise contributions from the GIS continue after AM begins. These continued sea level rise contributions persist for decades to centuries after temperature stabilization and temperature drawdown begin, unless AM begins in the next few decades. Moreover, (iii) any regrowth of the GIS is delayed by decades or centuries after temperature drawdown begins, and is slow compared to pre-AM rates of mass loss. Combined with recent work that suggests AM would not prevent mass loss from the West Antarctic Ice Sheet, our results provide a nuanced picture of AM’s possible effects on future sea-level rise. (letter)

  16. Duality gives rise to Chaplygin cosmologies with a big rip

    Chimento, Luis P; Lazkoz, Ruth

    2006-01-01

    We consider modifications to the Friedmann equation motivated by recent proposals along these lines pursuing an explanation to the observed late time acceleration. Here we show that these approaches can be framed within a theory with modified gravity, and we discuss the construction of the duals of the cosmologies generated within that framework. We then investigate the modifications required to generate extended, generalized and modified Chaplygin cosmologies, and then show that their duals belong to a larger family of cosmologies we call enlarged Chaplygin cosmologies. Finally, by letting the parameters of these models take values not earlier considered in the literature we show that some representatives of that family of cosmologies display sudden future singularities. This fact indicates that the behaviour of these spacetimes is rather different from that of generalized or modified Chaplygin gas cosmologies. This reinforces the idea that modifications of gravity can be responsible for unexpected evolutionary features in the universe

  17. Glioblastoma stem-like cells give rise to tumour endothelium

    Wang, Rong; Chadalavada, Kalyani; Wilshire, Jennifer; Kowalik, Urszula; Hovinga, Koos E.; Geber, Adam; Fligelman, Boris; Leversha, Margaret; Brennan, Cameron; Tabar, Viviane

    2010-01-01

    Glioblastoma (GBM) is among the most aggressive of human cancers. A key feature of GBMs is the extensive network of abnormal vasculature characterized by glomeruloid structures and endothelial hyperplasia. Yet the mechanisms of angiogenesis and the origin of tumour endothelial cells remain poorly

  18. Different Selection Pressures Give Rise to Distinct Ethnic Phenomena

    Moya, Cristina; Boyd, Robert

    2015-01-01

    Many accounts of ethnic phenomena imply that processes such as stereotyping, essentialism, ethnocentrism, and intergroup hostility stem from a unitary adaptation for reasoning about groups. This is partly justified by the phenomena’s co-occurrence in correlational studies. Here we argue that these behaviors are better modeled as functionally independent adaptations that arose in response to different selection pressures throughout human evolution. As such, different mechanisms may be triggered by different group boundaries within a single society. We illustrate this functionalist framework using ethnographic work from the Quechua-Aymara language boundary in the Peruvian Altiplano. We show that different group boundaries motivate different ethnic phenomena. For example, people have strong stereotypes about socioeconomic categories, which are not cooperative units, whereas they hold fewer stereotypes about communities, which are the primary focus of cooperative activity. We also show that, despite the cross-cultural importance of ethnolinguistic boundaries, the Quechua-Aymara linguistic distinction does not strongly motivate any of these intergroup processes. PMID:25731969

  19. The human elements in phenomena giving rise to nuclear accidents

    Carnino, A.; Raggenbass, A.

    1977-01-01

    In its search for a high degree of safety, the nuclear industry should take into account the human parameters, which play an important role. This role is reflected in the individual records kept on incidents and analysis of these records, as has been carried out in conventional industry, represents a first attempt to allow for this factor. The first inquiries covering the background of incidents led to a series of studies and action in respect of individual staff members: on the part of operators, education of personnel in relation to their duties (for example, simulation of reactor control) and attempts to find objective selection criteria for certain specific posts; on the part of those responsible for safety, ergonomic studies and studies on human reliability. For effective prevention of accidents it is necessary to move backwards along the causality chains and therefore to study a nuclear facility as a man-machine system in order to discover the greatest number of potential accident factors. The nuclear facility is introduced into an environment which imposes its rules, constraints and checks and a full study of the human element in safety implies that they should be taken into account. The programme of the Nuclear Safety Department of the Institute of Protection and Nuclear Safety includes not only systematic updating of incident records but also special ergonomic studies (maintenance in a radioactive environment), studies of human reliability and overall studies known as safety management studies. (author)

  20. Construction of computational program of aging in insulating materials for searching reversed sequential test conditions to give damage equivalent to simultaneous exposure of heat and radiation

    Fuse, Norikazu; Homma, Hiroya; Okamoto, Tatsuki

    2013-01-01

    Two consecutive numerical calculations on degradation of polymeric insulations under thermal and radiation environment are carried out to simulate so-called reversal sequential acceleration test. The aim of the calculation is to search testing conditions which provide material damage equivalent to the case of simultaneous exposure of heat and radiation. At least following four parameters are needed to be considered in the sequential method; dose rate and exposure time in radiation, as well as temperature and aging time in heating. The present paper discusses the handling of these parameters and shows some trial calculation results. (author)

  1. Variation Process of Radiation Belt Electron Fluxes due to Interaction With Chorus and EMIC Rising-tone Emissions Localized in Longitude

    Kubota, Y.; Omura, Y.

    2017-12-01

    Using results of test particle simulations of a large number of electrons interacting with a pair of chorus emissions, we create Green's functions to model the electron distribution function after all of the possible interactions with the waves [Omura et al., 2015]. Assuming that the waves are generated in a localized range of longitudes in the dawn side, we repeat taking the convolution integral of the Green's function with the distribution function of the electrons injected into the generation region of the localized waves. From numerical and theoretical analyses, we find that electron acceleration process only takes place efficiently below 4 MeV. Because extremely relativistic electrons go through the wave generation region rapidly due to grad-B0 and curvature drift, they don't have enough interaction time to be accelerated. In setting up the electrons after all interaction with chorus emissions as initial electron distribution function, we also compute the loss process of radiation belt electron fluxes due to interaction with EMIC rising-tone emissions generated in a localized range of longitudes in the dusk side [Kubota and Omura,2017]. References: (1) Omura, Y., Y. Miyashita, M. Yoshikawa, D. Summers, M. Hikishima, Y. Ebihara, and Y. Kubota (2015), Formation process of relativistic electron flux through interaction with chorus emissions in the Earth's inner magnetosphere, J. Geophys. Res. Space Physics, 120, 9545-9562, doi:10.1002/2015JA021563. (2) Kubota, Y., and Y. Omura (2017), Rapid precipitation of radiation belt electrons induced by EMIC rising tone emissions localized in longitude inside and outside the plasmapause, J. Geophys. Res. Space Physics, 122, 293-309, doi:10.1002/2016JA023267.

  2. Rising equity

    Burr, M.T.

    1992-01-01

    This article reports on the results of a financial rankings survey of the independent energy industry indicating that lenders and investors provided more than five billion dollars in capital for new, private power projects during the first six months of 1992. The topics of the article include rising equity requirements, corporate finance, mergers and acquisitions, project finance investors, revenue bonds, project finance lenders for new projects, project finance lenders for restructurings, and project finance advisors

  3. Radiation color and electron-hole centers of serpentines

    Lyutoev, V.P.; Yukhtanov, P.P.

    1999-01-01

    Radiation-induced coloring of serpentine (Mg 3 [Si 2 O 5 ](OH) 4 ), gamma radiation dose being 30 Mrad, is studied by the ESR and absorption spectroscopy methods. It is ascertained that ionizing radiation gives rise to formation of radiation centers on the mineral basic structural elements. paramagnetic centers and coloring centers, relating to radiation centers, stem from the same type of defects - O - oxygen centers, formed as a result of radiation-induced break of OH-bonds [ru

  4. Give Me Strength.

    维拉

    1996-01-01

    Mort had an absolutely terrible day at the office.Everythingthat could go wrong did go wrong.As he walked home he could beheard muttering strange words to himself:“Oh,give me strength,give me strength.”Mort isn’t asking for the kind of strength thatbuilds strong muscles:he’s asking for the courage or ability to

  5. The relationship of temperature rise to specific absorption rate and current in the human leg for exposure to electromagnetic radiation in the high frequency band

    Wainwright, P R

    2003-01-01

    Of the biological effects of human exposure to radiofrequency and microwave radiation, the best-established are those due to elevation of tissue temperature. To prevent harmful levels of heating, restrictions have been proposed on the specific absorption rate (SAR). However, the relationship between SAR and temperature rise is not an invariant, since not only the heat capacity but also the efficiency of heat dissipation varies between different tissues and exposure scenarios. For small enough SAR, the relationship is linear and may be characterized by a 'heating factor'. Under whole-body irradiation the SAR may be particularly high in the ankles due to the concentration of current flowing through a relatively small cross-sectional area. In a previous paper, the author has presented calculations of the SAR distribution in a human leg in the high frequency (HF) band. In this paper, the heating factor for this situation is derived using a finite element approximation of the Pennes bio-heat equation. The sensitivity of the results to different blood perfusion rates is investigated, and a simple local thermoregulatory model is applied. Both time-dependent and steady-state solutions are considered. Results confirm the appropriateness of the ICNIRP reference level of 100 mA on current through the leg, but suggest that at higher currents significant thermoregulatory adjustments to muscle blood flow will occur

  6. Giving behavior of millionaires.

    Smeets, Paul; Bauer, Rob; Gneezy, Uri

    2015-08-25

    This paper studies conditions influencing the generosity of wealthy people. We conduct incentivized experiments with individuals who have at least €1 million in their bank account. The results show that millionaires are more generous toward low-income individuals in a giving situation when the other participant has no power, than in a strategic setting, where the other participant can punish unfair behavior. Moreover, the level of giving by millionaires is higher than in any other previous study. Our findings have important implications for charities and financial institutions that deal with wealthy individuals.

  7. Giving Back, Moving Forward

    Louise Fortmann

    2014-07-01

    Full Text Available While reflecting on her own experience with giving back in Zimbabwe, Fortmann considers how the idea of “giving back” sits at the intersection of feminist theory, participatory research, and the democratization of science. From feminist theory arises the question of how to reciprocate to those who have contributed to our research. The participatory research and democratization of science literature push us to recognize and consider the collaborative nature of our research. Fortmann concludes by identifying three categories of reciprocity in research: material, intellectual, and personal. Sharing must occur, regardless of the kind of research taking place.

  8. Give blood at CERN

    SC Unit

    2008-01-01

    ACCIDENTS and ILLNESSES don’t take a break! DO SOMETHING AMAZING - GIVE BLOOD! IT’S IN ALL OUR INTERESTS. 30 July 2008 from 9.30 a.m. to 4 p.m. CERN RESTAURANT NOVAE First floor - Salle des Pas Perdus After you have given blood, you are invited to partake of refreshments kindly offered by NOVAE.

  9. Anisotropic conducting films for electromagnetic radiation applications

    Cavallo, Francesca; Lagally, Max G.; Rojas-Delgado, Richard

    2015-06-16

    Electronic devices for the generation of electromagnetic radiation are provided. Also provided are methods for using the devices to generate electromagnetic radiation. The radiation sources include an anisotropic electrically conducting thin film that is characterized by a periodically varying charge carrier mobility in the plane of the film. The periodic variation in carrier mobility gives rise to a spatially varying electric field, which produces electromagnetic radiation as charged particles pass through the film.

  10. Rise of a cold plume

    Kakuta, Michio

    1977-06-01

    The rise of smoke from the stacks of two research reactors in normal operation was measured by photogrametric method. The temperature of effluent gas is less than 20 0 C higher than that of the ambient air (heat emission of the order 10 4 cal s -1 ), and the efflux velocity divided by the wind speed is between 0.5 and 2.8 in all 16 smoke runs. The field data obtained within downwind distance of 150m are compared with those by plume rise formulas presently available. Considering the shape of bending-over plume, the Briggs' formula for 'jet' gives a reasonable explanation of the observed plume rise. (auth.)

  11. Plume rise from multiple sources

    Briggs, G.A.

    1975-01-01

    A simple enhancement factor for plume rise from multiple sources is proposed and tested against plume-rise observations. For bent-over buoyant plumes, this results in the recommendation that multiple-source rise be calculated as [(N + S)/(1 + S)]/sup 1/3/ times the single-source rise, Δh 1 , where N is the number of sources and S = 6 (total width of source configuration/N/sup 1/3/ Δh 1 )/sup 3/2/. For calm conditions a crude but simple method is suggested for predicting the height of plume merger and subsequent behavior which is based on the geometry and velocity variations of a single buoyant plume. Finally, it is suggested that large clusters of buoyant sources might occasionally give rise to concentrated vortices either within the source configuration or just downwind of it

  12. SPHINX: a generator based on 1 microsecond current rise time LTD stages. Status and first results for production of soft X-ray radiation

    Mangeant, Ch.; Roques, B.; Cadiergues, R.

    2005-01-01

    SPHINX is the new name of the facility developed for soft X-ray production. This facility is based on the ECF2 generator which was designed as a 1-3 MJ, 1 μs rise time, 5-10 MA current driver. We present a detailed view of the technology used for the capacitor bank, for the central vacuum part and for the Z-pinch loads [ru

  13. Radiation safety aspects in the use of radiation sources in industrial and heath-care applications

    Venkat Raj, V.

    2001-01-01

    The principle underlying the philosophy of radiation protection and safety is to ensure that there exists an appropriate standard of protection and safety for humans, without unduly limiting the benefits of the practices giving rise to exposure or incurring disproportionate costs in interventions. To realise these objectives, the International Commission on Radiation Protection (ICRP-60) and IAEA's Safety Series (IAEA Safety Series 120, 1996) have enunciated the following criteria for the application and use of radiation: (1) justification of practices; (2) optimisation of protection; (3) dose limitation and (4) safety of sources. Though these criteria are the basic tenets of radiation protection, the radiation hazard potentials of individual applications vary and the methods to achieve the above mentioned objectives principles are different. This paper gives a brief overview of the various applications of radiation and radioactive sources in India, their radiation hazard perspective and the radiation safety measures provided to achieve the basic radiation protection philosophy. (author)

  14. Composite heat transfer in a pipe with thermal radiation of two-dimensional propagation - in connection with the temperature rise in flowing medium upstream from heating section

    Echigo, R.; Hasegawa, S.; Kamiuto, K.

    1975-01-01

    An analytical procedure is presented for simultaneous convective and radiative heat transfer with a fully developed laminar flow in a pipe by taking account of the two-dimensional propagation of radiative transfer and also shows the numerical results on the temperature profiles and the heat-transfer characteristics. In order to solve the energy equation with two-dimensional radiative transfer the entire ranges of the temperature field have to be solved simultaneously both along the radial and flow directions. Moreover, the heat flux by thermal radiation emitted from the heating wall propagates upstream so that it is necessary to examine the temperature profiles of the flowing medium to a certain distance upstream from the entrance of the heating section. In this way in order to attempt to solve the governing equation numerically by a finite difference method the dimension of matrix becomes extremely large provided that a satisfactory validity of numerical calculation is required Consequently the band matrix method is used and the temperature profiles of the medium in both regions upstream and downstream from the entrance of the heating section are illustrated and the heat transfer results are discussed in some detail by comparing with those of the one-dimensional transfer of radiation.(auth)

  15. How to Safely Give Ibuprofen

    ... of ibuprofen are available in similar forms. How to Give When giving ibuprofen, refer to the following dosage ... of Use Notice of Nondiscrimination Visit the Nemours Web site. Note: All information on KidsHealth® is for ...

  16. Radiation

    2013-01-01

    The chapter one presents the composition of matter and atomic theory; matter structure; transitions; origin of radiation; radioactivity; nuclear radiation; interactions in decay processes; radiation produced by the interaction of radiation with matter

  17. The radiation chemistry of macromolecules

    1973-01-01

    The Radiation Chemistry of Macromolecules, Volume II is a collection of papers that discusses radiation chemistry of specific systems. Part 1 deals with radiation chemistry of substituted vinyl polymers, particularly polypropylene (PP) as its structure is intermediate between polyethylene and polyisobutylene. This part also discusses polypropylene oxide (PPOx) for it can be prepared in the atactic, isotactic, and optically active forms. One paper focuses on the fundamental chemical processes and the changes in physical properties that give rise to many different applications of polystyrene. An

  18. Radiation-Induced Bystander Response: Mechanism and Clinical Implications

    Suzuki, Keiji; Yamashita, Shunichi

    2014-01-01

    Significance: Absorption of energy from ionizing radiation (IR) to the genetic material in the cell gives rise to damage to DNA in a dose-dependent manner. There are two types of DNA damage; by a high dose (causing acute or deterministic effects) and by a low dose (related to chronic or stochastic effects), both of which induce different health effects. Among radiation effects, acute cutaneous radiation syndrome results from cell killing as a consequence of high-dose exposure.

  19. The Limits to Giving Back

    Jade S. Sasser

    2014-07-01

    Full Text Available In this thematic section, authors consider the limitations on giving back that they faced in field research, or saw others face. For some authors, their attempts at giving back were severely limited by the scope of their projects, or their understandings of local cultures or histories. For others, very specific circumstances and historical interventions of foreigners in certain places can limit how and to what extent a researcher is able to have a reciprocal relationship with the participating community. Some authors, by virtue of their lesser positions of power relative to those that they were studying, simply decided not to give back to those communities. In each article it becomes apparent that how and in what ways people give back is unique (and limited both to their personal values and the contexts in which they do research.

  20. Effect of a gravitational wave on electromagnetic radiation confined in a cavity

    Tourrenc, P.

    1978-01-01

    Gravitational radiation is considered within the first-order approximation. A pattern of an electromagnetic cavity is studied: Gravitational waves give rise to a deformation of the planes limiting the cavity. This deformation alters the electromagnetic radiation. Several cases are studied and orders of magnitude are put forward. (author)

  1. Upfront Androgen Deprivation Therapy With Salvage Radiation May Improve Biochemical Outcomes in Prostate Cancer Patients With Post-Prostatectomy Rising PSA

    Jang, Joanne W. [Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States); Hwang, Wei-Ting [Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States); Guzzo, Thomas J.; Wein, Alan J. [Department of Urology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States); Haas, Naomi B. [Department of Medical Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States); Both, Stefan [Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States); Vapiwala, Neha, E-mail: vapiwala@uphs.upenn.edu [Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, PA (United States)

    2012-08-01

    Purpose: The addition of androgen deprivation therapy (ADT) to definitive external beam radiation therapy (RT) improves outcomes in higher-risk prostate cancer patients. However, the benefit of ADT with salvage RT in post-prostatectomy patients is not clearly established. Our study compares biochemical outcomes in post-prostatectomy patients who received salvage RT with or without concurrent ADT. Methods and Materials: Of nearly 2,000 post-prostatectomy patients, we reviewed the medical records of 191 patients who received salvage RT at University of Pennsylvania between 1987 and 2007. Follow-up data were obtained by chart review and electronic polling of the institutional laboratory database and Social Security Death Index. Biochemical failure after salvage RT was defined as a prostate-specific antigen of 2.0 ng/mL above the post-RT nadir or the initiation of ADT after completion of salvage RT. Results: One hundred twenty-nine patients received salvage RT alone, and 62 patients received combined ADT and salvage RT. Median follow-up was 5.4 years. Patients who received combined ADT and salvage RT were younger, had higher pathologic Gleason scores, and higher rates of seminal vesicle invasion, lymph node involvement, and pelvic nodal irradiation compared with patients who received salvage RT alone. Patients who received combined therapy had improved biochemical progression-free survival (bPFS) compared with patients who received RT alone (p = 0.048). For patients with pathologic Gleason scores {<=}7, combined RT and ADT resulted in significantly improved bPFS compared to RT alone (p = 0.013). Conclusions: These results suggest that initiating ADT during salvage RT in the post-prostatectomy setting may improve bPFS compared with salvage RT alone. However, prospective randomized data are necessary to definitively determine whether hormonal manipulation should be used with salvage RT. Furthermore, the optimal nature and duration of ADT and the patient subgroups in

  2. GIVING AND RECEIVING CONSTRUCTIVE FEEDBACK

    Ірина Олійник

    2015-05-01

    Full Text Available The article scrutinizes the notion of feedback applicable in classrooms where team teaching is provided. The experience of giving and receiving feedback has been a good practice in cooperation between a U.S. Peace Corps volunteer and a Ukrainian counterpart. Giving and receiving feedback is an effective means of classroom observation that provides better insight into the process of teaching a foreign language. The article discusses the stages of feedback and explicates the notion of sharing experience between two teachers working simultaneously in the same classroom. The guidelines for giving and receiving feedback have been provided as well as the most commonly used vocabulary items have been listed. It has been proved that mutual feedback leads to improving teaching methods and using various teaching styles and techniques.

  3. The New Planned Giving Officer.

    Jordan, Ronald R.; Quynn, Katelyn L.

    1994-01-01

    A planned giving officer is seen as an asset to college/university development for technical expertise, credibility, and connections. Attorneys, certified public accountants, bank trust officers, financial planners, investment advisers, life insurance agents, and real estate brokers may be qualified but probably also need training. (MSE)

  4. (Micro)Financing to Give

    Bajde, Domen

    2013-01-01

    and workings of microfinance. We illustrate how market-like elements are productively and problematically deployed in philanthropic giving and address the need to consider a broader range of socio-material relations involved in the framing of transactions. A complex network of actors and (trans)actions needs...

  5. Producers give prices a boost

    Anon.

    1992-01-01

    Uranium producers came alive in August, helping spot prices crack the $8.00 barrier for the first time since March. The upper end of NUKEM's price range actually finished the month at $8.20. Scrambling to fulfill their long-term delivery contracts, producers dominate the market. In the span of three weeks, five producers came out for 2 million lbs U3O8, ultimately buying nearly 1.5 million lbs. One producer accounted for over half this volume. The major factor behind rising prices was that producers required specific origins to meet contract obligations. Buyers willing to accept open origins created the lower end of NUKEM's price range

  6. Radiation from nitrogen molecule due to electron impact

    Khare, S P; Kumar, A

    1977-01-01

    A review is presented of the experimental results of the collisional cross sections of the nitrogen molecules due to electron impact which give rise to radiations in the 3,000 Angstrom to 10,500 Angstron wavelength region. Calculations of the fluorescence efficiencies are described and are compared with experimental data. (GHT)

  7. Fast rise time IR detectors for lepton colliders

    Drago, A.; Bini, S.; Guidi, M. Cestelli; Marcelli, A.; Pace, E.

    2016-01-01

    Diagnostics is a fundamental issue for accelerators whose demands are continuously increasing. In particular bunch-by-bunch diagnostics is a key challenge for the latest generation of lepton colliders and storage rings. The Frascati Φ-factory, DAΦNE, colliding at 1.02 GeV in the centre of mass, hosts in the main rings few synchrotron radiation beamlines and two of them collect the synchrotron radiation infrared emission: SINBAD from the electron ring and 3+L from the positron ring. At DAΦNE each bucket is 2.7 ns long and particles are gathered in bunches emitting pulsed IR radiation, whose intensity in the long wavelength regime is directly proportional to the accumulated particles. Compact uncooled photoconductive HgCdTe detectors have been tested in both beamlines using dedicated optical layouts. Actually, the fast rise time of HgCdTe semiconductors give us the chance to test bunch-by-bunch devices for both longitudinal and transverse diagnostics. For the longitudinal case, single pixel detectors have been used, while for the transverse diagnostics, multi-pixel array detectors, with special custom design, are under test. This contribution will briefly describe the status of the research on fast IR detectors at DAΦNE, the results obtained and possible foreseen developments.

  8. Ultraviolet radiation

    Faber, M.

    1989-01-01

    Although UV radiation can arise from a large number of man-made sources, the sun is the main source and both the general public and people working out of doors will be exposed to it. This natural background radiation and the variations in its magnitude must be taken into account when exposure limits are discussed. The full extent to which UV affects human well-being is difficult to quantify. Artificially produced UV has, however, been used in mines and cellars and in far northern latitudes as a supplement to combat functional impairment among people. Many of the observed effects, such as a decrease in the incidence of infectious diseases and in absenteeism, may be due to the bactericidal nature of the radiation. On the other hand, large doses of UV have an acute destructive effect on the skin and eye. Doses so low that they give rise only to normally acceptable or even desirable acute effects can, if repeated, induce changes resulting in late effects such as elastosis of the skin, keratosis and skin cancers. These effects will be of greater significance in people with lightly pigmented skin. 130 refs, 13 figs, 2 tabs

  9. Analysis gives sensibility two models gives migration and transport gives radionuclides in the geosphere

    Torres Berdeguez, M. B.; Gil Castillo, R.; Peralta Vidal, J.L.

    1998-01-01

    An sensibility analysis it was applied two models, the first one, a model compressible for the near field (I finish source) The second, a simple model gives migration and transport radionuclides in the geosphere. The study was developed varying the securities ed simultaneously at the same time each parameter and observing the results in changes in the output and input. The intention in analysis it is to determine the parameter that but it influences in the variation the concentration. The statistical technique Regression it was employee in the study. This statistical method is used to analyze the dependence between a dependent variable and an or but independent variables

  10. The Rise of Iran

    Rahigh-Aghsan, Ali

    Iran is viewed as a rising power that poses an increasing threat to regional and even global security. This view is wrong for three reasons. Iran's hard and soft power is exaggerated by most accounts; it is too limited to allow the Iranians to dominate the Persian Gulf let alone the Middle East...

  11. The Rise of Iran

    Rahigh-Aghsan, Ali; Jakobsen, Peter Viggo

    2010-01-01

    Iran is viewed as a rising power that poses an increasing threat to regional and even global security. This view is wrong for three reasons. Iran's hard and soft power is exaggerated by most accounts; it is too limited to allow the Iranians to dominate the Persian Gulf let alone the Middle East...

  12. Measurement of background gamma radiation in the northern Marshall Islands

    Bordner, Autumn S.; Crosswell, Danielle A.; Katz, Ainsley O.; Shah, Jill T.; Zhang, Catherine R.; Nikolic-Hughes, Ivana; Hughes, Emlyn W.; Ruderman, Malvin A.

    2016-01-01

    Sixty-seven nuclear tests were conducted on two atolls in the northern Marshall Islands between 1946 and 1958. These tests produced radioactive fallout, which even today gives rise to radiation measurable above naturally occurring background levels. Rather than obtain new data, recent estimates of contamination levels in the northern Marshall Islands use measurements made decades ago to calculate present radiation levels. In contrast, we report on timely measurements on three different atolls...

  13. Wandering towards a goal how can mindless mathematical laws give rise to aims and intention?

    Foster, Brendan; Merali, Zeeya

    2018-01-01

    This collection of prize-winning essays addresses the controversial question of how meaning and goals can emerge in a physical world governed by mathematical laws. What are the prerequisites for a system to have goals? What makes a physical process into a signal? Does eliminating the homunculus solve the problem? The three winning essays, by Larissa Albantakis, Carlo Rovelli and Jochen Szangolies tackle exactly these challenges, while many other aspects (agency, the role of the observer, causality versus teleology, ghosts in the machine etc.) put in an appearance in the other award winning contributions. These seventeen imaginative, stimulating and often entertaining essays are enhanced versions of the prize-winning entries to the FQXi essay competition in 2017. The Foundational Questions Institute, FQXi, catalyzes, supports, and disseminates research on questions at the foundations of physics and cosmology, particularly new frontiers and innovative ideas integral to a deep understanding of reality, but unlik...

  14. An explanatory heuristic gives rise to the belief that words are well suited for their referents.

    Sutherland, Shelbie L; Cimpian, Andrei

    2015-10-01

    The mappings between the words of a language and their meanings are arbitrary. There is, for example, nothing inherently dog-like about the word dog. And yet, building on prior evidence (e.g., Brook, 1970; Piaget, 1967), the six studies reported here (N=1062) suggest that both children and (at least to some extent) adults see a special "fit" between objects and their names, as if names were particularly suitable or appropriate for the objects they denote. These studies also provide evidence for a novel proposal concerning the source of these nominal fit beliefs. Specifically, beliefs about nominal fit may be a byproduct of the heuristic processes that people use to make sense of the world more generally (Cimpian & Salomon, 2014a). In sum, the present studies provide new insights into how people conceive of language and demonstrate that these conceptions are rooted in the processes that underlie broader explanatory reasoning. Copyright © 2015 Elsevier B.V. All rights reserved.

  15. Condensation of Counterions Gives Rise to Contraction Transitions in a One-Dimensional Polyelectrolyte Gel

    Gerald S. Manning

    2018-04-01

    Full Text Available The equilibrium volume of a polyelectrolyte gel results from a balance between the tendency to swell caused by outbound polymer/counterion diffusion along with Coulomb interactions on the one hand; and, on the other, the elastic resilience of the cross-linked polymer network. Direct Coulomb forces contribute both to non-ideality of the equilibrated Donnan osmotic pressure, but also to stretching of the network. To isolate the effect of polyelectrolyte expansion, we have analyzed a “one-dimensional” version of a gel, a linear chain of charged beads connected by Hooke’s law springs. As in the range of weak Coulomb strengths previously studied, the springs are significantly stretched by the repulsive interactions among the beads even when the Coulomb strength is strong enough to cause condensation of counterions. There is a quasi-abrupt transition from a stretched state to a partially collapsed state in a transition range between weak and strong Coulomb strengths. Fluctuations between stretched and contracted conformations occur within the transition range. As the solvent quality decreases past the transition range, a progressive collapse can result if the condensed counterions strengthen the spring constant.

  16. Macromolecular crowding gives rise to microviscosity, anomalous diffusion and accelerated actin polymerization.

    Rashid, Rafi; Chee, Stella Min Ling; Raghunath, Michael; Wohland, Thorsten

    2015-04-30

    Macromolecular crowding (MMC) has been used in various in vitro experimental systems to mimic in vivo physiology. This is because the crowded cytoplasm of cells contains many different types of solutes dissolved in an aqueous medium. MMC in the extracellular microenvironment is involved in maintaining stem cells in their undifferentiated state (niche) as well as in aiding their differentiation after they have travelled to new locations outside the niche. MMC at physiologically relevant fractional volume occupancies (FVOs) significantly enhances the adipogenic differentiation of human bone marrow-derived mesenchymal stem cells during chemically induced adipogenesis. The mechanism by which MMC produces this enhancement is not entirely known. In the context of extracellular collagen deposition, we have recently reported the importance of optimizing the FVO while minimizing the bulk viscosity. Two opposing properties will determine the net rate of a biochemical reaction: the negative effect of bulk viscosity and the positive effect of the excluded volume, the latter being expressed by the FVO. In this study we have looked more closely at the effect of viscosity on reaction rates. We have used fluorimetry to measure the rate of actin polymerization and fluorescence correlation spectroscopy (FCS) to measure diffusion of various probes in solutions containing the crowder Ficoll at physiological concentrations. Similar to its effect on collagen, Ficoll enhanced the actin polymerization rate despite increasing the bulk viscosity. Our FCS measurements reveal a relatively minor component of anomalous diffusion. In addition, our measurements do suggest that microviscosity becomes relevant in a crowded environment. We ruled out bulk viscosity as a cause of the rate enhancement by performing the actin polymerization assay in glycerol. These opposite effects of Ficoll and glycerol led us to conclude that microviscosity becomes relevant at the length scale of the reacting molecules within a crowded microenvironment. The excluded volume effect (arising from crowding) increases the effective concentration of actin, which increases the reaction rate, while the microviscosity does not increase sufficiently to lower the reaction rate. This study reveals finer details about the mechanism of MMC.

  17. Macromolecular crowding gives rise to microviscosity, anomalous diffusion and accelerated actin polymerization

    Rashid, Rafi; Chee, Stella Min Ling; Raghunath, Michael; Wohland, Thorsten

    2015-05-01

    Macromolecular crowding (MMC) has been used in various in vitro experimental systems to mimic in vivo physiology. This is because the crowded cytoplasm of cells contains many different types of solutes dissolved in an aqueous medium. MMC in the extracellular microenvironment is involved in maintaining stem cells in their undifferentiated state (niche) as well as in aiding their differentiation after they have travelled to new locations outside the niche. MMC at physiologically relevant fractional volume occupancies (FVOs) significantly enhances the adipogenic differentiation of human bone marrow-derived mesenchymal stem cells during chemically induced adipogenesis. The mechanism by which MMC produces this enhancement is not entirely known. In the context of extracellular collagen deposition, we have recently reported the importance of optimizing the FVO while minimizing the bulk viscosity. Two opposing properties will determine the net rate of a biochemical reaction: the negative effect of bulk viscosity and the positive effect of the excluded volume, the latter being expressed by the FVO. In this study we have looked more closely at the effect of viscosity on reaction rates. We have used fluorimetry to measure the rate of actin polymerization and fluorescence correlation spectroscopy (FCS) to measure diffusion of various probes in solutions containing the crowder Ficoll at physiological concentrations. Similar to its effect on collagen, Ficoll enhanced the actin polymerization rate despite increasing the bulk viscosity. Our FCS measurements reveal a relatively minor component of anomalous diffusion. In addition, our measurements do suggest that microviscosity becomes relevant in a crowded environment. We ruled out bulk viscosity as a cause of the rate enhancement by performing the actin polymerization assay in glycerol. These opposite effects of Ficoll and glycerol led us to conclude that microviscosity becomes relevant at the length scale of the reacting molecules within a crowded microenvironment. The excluded volume effect (arising from crowding) increases the effective concentration of actin, which increases the reaction rate, while the microviscosity does not increase sufficiently to lower the reaction rate. This study reveals finer details about the mechanism of MMC.

  18. An extension to Galilean relativity gives rise to quantum mechanics framework

    Berkovich, Simon

    The presented scheme for quantum mechanics appeared from considering Cellular Automaton Universe in view of the hidden energy associated with the property of inertia. Galilean relativity states that all inertial frames are equivalent. Our consideration reveals one seemingly small exception - the original frame of reference for the material formations of the Cellular Automaton infrastructure is not isotropic. This frame of reference has a distinctive direction as long as elementary particles of matter are generated by cellular automaton relocations As a result, Cellular Automaton Universe basically complying with the laws of macrophysics for bulk bodies, could exhibit peculiar characteristics for microphysics.. Why the states of microobjects are described by complex numbers is obscure. The observables are presented by real numbers through corresponding macro manipulations. In the inertial frame with unidirectional anisotropy isolated particles are characterized by two numbers; magnitude of their velocity and inclination angle to motion direction. So, these quantum states are mapped to a complex Hilbert space with zero vector representing bulk bodies. The effect of spin may be associated with the sign of the inclination angle trending separations for Stern-Gerlach output and Paul Principle. Emeritus.

  19. Myxoid stroma and delicate vasculature of a superficial angiomyxoma give rise to the red planet sign

    Green, Margaret; Logemann, Nichola; Sulit, Daryl J

    2014-01-01

    Superficial angiomyxomas are uncommon benign mesenchymal tumors. They often recur locally if partially removed. This case report demonstrates not only the characteristic pathological findings of a superficial angiomyxoma in a 33- year-old man, but also shows a unique dermatoscopic image, which in our estimation resembles a celestial red planet such as the blood moon seen during a lunar eclipse. We propose to call this the “red planet” sign for a superficial angiomyxoma on dermoscopic examinat...

  20. Myxoid stroma and delicate vasculature of a superficial angiomyxoma give rise to the red planet sign.

    Green, Margaret; Logemann, Nichola; Sulit, Daryl J

    2014-09-16

    Superficial angiomyxomas are uncommon benign mesenchymal tumors. They often recur locally if partially removed. This case report demonstrates not only the characteristic pathological findings of a superficial angiomyxoma in a 33- year-old man, but also shows a unique dermatoscopic image, which in our estimation resembles a celestial red planet such as the blood moon seen during a lunar eclipse. We propose to call this the "red planet" sign for a superficial angiomyxoma on dermoscopic examination.

  1. Driven to distraction: A lack of change gives rise to mind wandering.

    Faber, Myrthe; Radvansky, Gabriel A; D'Mello, Sidney K

    2018-04-01

    How does the dynamic structure of the external world direct attention? We examined the relationship between event structure and attention to test the hypothesis that narrative shifts (both theoretical and perceived) negatively predict attentional lapses. Self-caught instances of mind wandering were collected while 108 participants watched a 32.5 min film called The Red Balloon. We used theoretical codings of situational change and human perceptions of event boundaries to predict mind wandering in 5-s intervals. Our findings suggest a temporal alignment between the structural dynamics of the film and mind wandering reports. Specifically, the number of situational changes and likelihood of perceiving event boundaries in the prior 0-15 s interval negatively predicted mind wandering net of low-level audiovisual features. Thus, mind wandering is less likely to occur when there is more event change, suggesting that narrative shifts keep attention from drifting inwards. Copyright © 2018 Elsevier B.V. All rights reserved.

  2. Primitive human hematopoietic cells give rise to differentially specified daughter cells upon their initial cell division.

    Giebel, B.; Zhang, T.; Beckmann, J.; Spanholtz, J.; Wernet, P.; Ho, A.; Punzel, M.

    2006-01-01

    It is often predicted that stem cells divide asymmetrically, creating a daughter cell that maintains the stem-cell capacity, and 1 daughter cell committed to differentiation. While asymmetric stem-cell divisions have been proven to occur in model organisms (eg, in Drosophila), it remains illusive

  3. 45 CFR 77.3 - Conditions that may give rise to remedial actions.

    2010-10-01

    ... cash management system fails to comply with generally accepted accounting principles or Departmental regulations or demonstrates irregularities, misrepresentations, fraud, or abuse in its operation. ...

  4. Treatment Outcomes from 68Ga-PSMA PET/CT-Informed Salvage Radiation Treatment in Men with Rising PSA After Radical Prostatectomy: Prognostic Value of a Negative PSMA PET.

    Emmett, Louise; van Leeuwen, Pim J; Nandurkar, Rohan; Scheltema, Matthijs J; Cusick, Thomas; Hruby, George; Kneebone, Andrew; Eade, Thomas; Fogarty, Gerald; Jagavkar, Raj; Nguyen, Quoc; Ho, Bao; Joshua, Anthony M; Stricker, Phillip

    2017-12-01

    68 Ga-PSMA (prostate-specific membrane antigen) PET/CT is increasingly used in men with prostate-specific antigen (PSA) failure after radical prostatectomy (RP) to triage those who will benefit from salvage radiation treatment (SRT). This study examines the value of PSMA-informed SRT in improving treatment outcomes in the context of biochemical failure after RP. Methods: We analyzed men with rising PSA after RP with PSA readings between 0.05 and 1.0 ng/mL, considered eligible for SRT at the time of PSMA. For each patient, clinical and pathologic features as well as scan results, including site of PSMA-positive disease, number of lesions, and a certainty score, were documented. Subsequent management, including SRT, and most recent PSA were recorded using medical records. Treatment response was defined as both PSA ≤ 0.1 ng/mL and >50% reduction in PSA. Multivariate logistic regression analysis was performed for association of clinical variables and treatment response to SRT. Results: One hundred sixty-four men were included. PSMA was positive in 62% ( n = 102/164): 38 of 102 in the prostatic fossa, 41 of 102 in pelvic nodes, and 23 of 102 distantly. Twenty-four patients received androgen-deprivation therapy (ADT) and were excluded for outcomes analysis. In total, 99 of 146 received SRT with a median follow-up after radiation treatment of 10.5 mo (interquartile range, 6-14 mo). Overall treatment response after SRT was 72% ( n = 71/99). Forty-five percent ( n = 27/60) of patients with a negative PSMA underwent SRT whereas 55% (33/60) did not. In men with a negative PSMA who received SRT, 85% ( n = 23/27) demonstrated a treatment response, compared with a further PSA increase in 65% (22/34) in those not treated. In 36 of 99 patients with disease confined to the prostate fossa on PSMA, 81% ( n = 29/36) responded to SRT. In total, 26 of 99 men had nodal disease on PSMA, of whom 61% ( n = 16/26) had treatment response after SRT. On multivariate logistic regression

  5. The Rise of Iran

    Jakobsen, Peter Viggo; Rahigh-Aghsan, Ali

    2010-01-01

    Iran is viewed by many as a rising power that poses an increasing threat to regional and even global security. This view is wrong for three reasons. Iran's hard and soft power is exaggerated by most accounts; it is too limited to allow the Iranians to dominate the Persian Gulf let alone the Middle...... East, and its brand of Shi‘ism has very limited appeal outside of Iran. Second, growing internal political and economic instability will seriously limit Iran's bid for regional dominance. Third, the failure to stop the Iranian nuclear program has led analysts to underestimate the ability of the other...... regional powers and the West to balance Iran and contain its influence, even if it acquires nuclear weapons. If these limitations on Iranian power are taken into account the rise seems destined to be a short one....

  6. The radiation environment of proton accelerators and storage rings

    Stevenson, G.R.

    1976-01-01

    These lecture notes survey the physical processes that give rise to the stray-radiation environment of proton synchrotrons and storage rings, with emphasis on their importance for radiation protection. The origins of the prompt radiation field (which disappears when the accelerator is switched off) are described in some detail: proton-nucleus interactions, extranuclear cascades, muon generation and transport. The effects of induced radioactivity in the accelerator structure and surroundings, notably in iron, concrete, air, and water, are discussed and methods for monitoring hadrons in the radiation environment outside the accelerator are listed. Seventy-six references to the literature are included. (Author)

  7. Radiation environment of proton accelerators and storage rings

    Stevenson, G R

    1976-03-08

    These lecture notes survey the physical processes that give rise to the stray-radiation environment of proton synchrotrons and storage rings, with emphasis on their importance for radiation protection. The origins of the prompt radiation field (which disappears when the accelerator is switched off) are described in some detail: proton-nucleus interactions, extranuclear cascades, muon generation and transport. The effects of induced radioactivity in the accelerator structure and surroundings, notably in iron, concrete, air, and water, are discussed, and methods for monitoring hadrons in the radiation environment outside the accelerator are listed. Seventy-six references to the literature are included.

  8. Contemporary sea level rise.

    Cazenave, Anny; Llovel, William

    2010-01-01

    Measuring sea level change and understanding its causes has considerably improved in the recent years, essentially because new in situ and remote sensing observations have become available. Here we report on most recent results on contemporary sea level rise. We first present sea level observations from tide gauges over the twentieth century and from satellite altimetry since the early 1990s. We next discuss the most recent progress made in quantifying the processes causing sea level change on timescales ranging from years to decades, i.e., thermal expansion of the oceans, land ice mass loss, and land water-storage change. We show that for the 1993-2007 time span, the sum of climate-related contributions (2.85 +/- 0.35 mm year(-1)) is only slightly less than altimetry-based sea level rise (3.3 +/- 0.4 mm year(-1)): approximately 30% of the observed rate of rise is due to ocean thermal expansion and approximately 55% results from land ice melt. Recent acceleration in glacier melting and ice mass loss from the ice sheets increases the latter contribution up to 80% for the past five years. We also review the main causes of regional variability in sea level trends: The dominant contribution results from nonuniform changes in ocean thermal expansion.

  9. Radiations

    Pujol Mora, J.

    1999-01-01

    The exposition to ionizing radiations is a constant fact in the life of the human being and its utilization as diagnostic and therapeutic method is generalized. However, it is notorious how as years go on, the fear to the ionizing radiation seems to persist too, and this fact is not limited to the common individual, but to the technical personnel and professional personnel that labors with them same. (S. Grainger) [es

  10. Radiation

    Davidson, J.H.

    1986-01-01

    The basic facts about radiation are explained, along with some simple and natural ways of combating its ill-effects, based on ancient healing wisdom as well as the latest biochemical and technological research. Details are also given of the diet that saved thousands of lives in Nagasaki after the Atomic bomb attack. Special comment is made on the use of radiation for food processing. (U.K.)

  11. Enhanced performance on high current discharges in JET produced by ICRF heating during the current rise

    Bures, M.; Bhatnagar, V.; Cotrell, G.; Corti, S.; Christiansen, J.P.; Hellsten, T.; Jacquinot, J.; Lallia, P.; Lomas, P.; O'Rourke, J.; Taroni, A.; Tibone, F.; Start, D.F.H.

    1989-01-01

    The performance of high current discharges can be increased by applying central ICRF heating before or shortly after the onset of sawtooth activity in the plasma current rise phase. Sawtooth-free periods have been obtained resulting in the enhanced discharge performance. High T e (0) 9 - 10.5 keV with peaked profiles T e (0)/ e > = 3 - 4 were obtained giving values of n e (0)T e (0) up to 6x10 20 (keV m -3 ). Improvements in T i (0) and neutron production are observed. A 60 % enhancement in D-D reaction rate from 2nd harmonic deuterium (2ω CD ) heating appears to be present. In all current rise (CR) discharges radiation amounts to 25-50 % of total power. (author) 4 refs., 6 figs

  12. To give or not to give, that's the question: How methodology is destiny in Dutch giving data

    Bekkers, R.H.F.P.; Wiepking, P.

    2006-01-01

    In research on giving, methodology is destiny. The volume of donations estimated from sample surveys strongly depends on the length of the questionnaire used to measure giving. By comparing two giving surveys from the Netherlands, the authors show that a short questionnaire on giving not only

  13. To Give or Not to Give, That Is the Question : How Methodology Is Destiny in Dutch Giving Data

    Bekkers, René; Wiepking, Pamala

    2006-01-01

    In research on giving, methodology is destiny. The volume of donations estimated from sample surveys strongly depends on the length of the questionnaire used to measure giving. By comparing two giving surveys from the Netherlands, the authors show that a short questionnaire on giving not only

  14. Coal prices rise

    McLean, A.

    2001-01-01

    Coking and semi hard coking coal price agreements had been reached, but, strangely enough, the reaching of common ground on semi soft coking coal, ultra low volatile coal and thermal coal seemed some way off. More of this phenomenon later, but suffice to say that, traditionally, the semi soft and thermal coal prices have fallen into place as soon as the hard, or prime, coking coal prices have been determined. The rise and rise of the popularity of the ultra low volatile coals has seen demand for this type of coal grow almost exponentially. Perhaps one of the most interesting facets of the coking coal settlements announced to date is that the deals appear almost to have been preordained. The extraordinary thing is that the preordination has been at the prescience of the sellers. Traditionally, coking coal price fixing has been the prerogative of the Japanese Steel Mills (JSM) cartel (Nippon, NKK, Kawasaki, Kobe and Sumitomo) who presented a united front to a somewhat disorganised force of predominantly Australian and Canadian sellers. However, by the time JFY 2001 had come round, the rules of the game had changed

  15. Concrete radiation shielding

    Kaplan, M.F.

    1989-01-01

    The increased use of nuclear energy has given rise to a growth in the amount of artificially produced radiation and radioactive materials. The design and construction of shielding to protect people, equipment and structures from the effects of radiation has never been more important. Experience has shown that concrete is an effective, versatile and economical material for the construction of radiation shielding. This book provides information on the principles governing the interaction of radiation with matter and on relevant nuclear physics to give the engineer an understanding of the design and construction of concrete shielding. It covers the physical, mechanical and nuclear properties of concrete; the effects of elevated temperatures and possible damage to concrete due to radiation; basic procedures for the design of concrete radiation shields and finally the special problems associated with their construction and cost. Although written primarily for engineers concerned with the design and construction of concrete shielding, the book also reviews the widely scattered data and information available on this subject and should therefore be of interest to students and those wishing to research further in this field. (author)

  16. Anthropogenic forcing dominates sea level rise since 1850

    Jevrejeva, Svetlana; Grinsted, Aslak; Moore, John

    2009-01-01

    The rate of sea level rise and its causes are topics of active debate. Here we use a delayed response statistical model to attribute the past 1000 years of sea level variability to various natural (volcanic and solar radiative) and anthropogenic (greenhouse gases and aerosols) forcings. We show...... that until 1800 the main drivers of sea level change are volcanic and solar radiative forcings. For the past 200 years sea level rise is mostly associated with anthropogenic factors. Only 4 ± 1.5 cm (25% of total sea level rise) during the 20th century is attributed to natural forcings, the remaining 14 ± 1...

  17. The rise of Chrome

    Jonathan Tamary

    2015-10-01

    Full Text Available Since Chrome’s initial release in 2008 it has grown in market share, and now controls roughly half of the desktop browsers market. In contrast with Internet Explorer, the previous dominant browser, this was not achieved by marketing practices such as bundling the browser with a pre-loaded operating system. This raises the question of how Chrome achieved this remarkable feat, while other browsers such as Firefox and Opera were left behind. We show that both the performance of Chrome and its conformance with relevant standards are typically better than those of the two main contending browsers, Internet Explorer and Firefox. In addition, based on a survey of the importance of 25 major features, Chrome product managers seem to have made somewhat better decisions in selecting where to put effort. Thus the rise of Chrome is consistent with technical superiority over the competition.

  18. Enhanced performance of high current discharges in JET produced by ICRF heating during the current rise

    Bures, M.; Bhatnagar, V.; Christiansen, J.P.

    1989-01-01

    The performance of high current discharges can be improved by applying central ICRF heating before or shortly after the onset of sawtooth activity in the plasma current rise phase. Long sawtooth-free periods have been obtained which result in a transiently-enhanced discharge performance. High T c (0) = 9-10.5 keV with peaked profile T e (0)/ e > = 3-4 were obtained giving values of N e (0)T e (0) up to 6 x 10 20 (keV m -3 ). Improvements in T i (0) and neutron production are observed. A best value of n Dd (0)T i (0)τ E = 1.65 x 10 20 (m -3 keV s) was achieved. Local transport simulation shows that the electron and ion thermal diffusivities do not differ substantially in the two cases of current-rise (CR) and flat-top (FT) heating, the performance of the central plasma region being enhanced, in the case of current-rise, entirely by the elimination of the sawtooth instability. The maximum D-D reaction rate is enhanced by a factor of 2 compared to the flat-top value. An appreciable part of the reaction rate is attributed to 2nd harmonic deuterium (2ω CD ) heating. In all current-rise discharges radiation amounts to 25-50% of total power and Ζ eff remains roughly constant. (author)

  19. Plume rise predictions

    Briggs, G.A.

    1976-01-01

    Anyone involved with diffusion calculations becomes well aware of the strong dependence of maximum ground concentrations on the effective stack height, h/sub e/. For most conditions chi/sub max/ is approximately proportional to h/sub e/ -2 , as has been recognized at least since 1936 (Bosanquet and Pearson). Making allowance for the gradual decrease in the ratio of vertical to lateral diffusion at increasing heights, the exponent is slightly larger, say chi/sub max/ approximately h/sub e/ - 2 . 3 . In inversion breakup fumigation, the exponent is somewhat smaller; very crudely, chi/sub max/ approximately h/sub e/ -1 . 5 . In any case, for an elevated emission the dependence of chi/sub max/ on h/sub e/ is substantial. It is postulated that a really clever ignorant theoretician can disguise his ignorance with dimensionless constants. For most sources the effective stack height is considerably larger than the actual source height, h/sub s/. For instance, for power plants with no downwash problems, h/sub e/ is more than twice h/sub s/ whenever the wind is less than 10 m/sec, which is most of the time. This is unfortunate for anyone who has to predict ground concentrations, for he is likely to have to calculate the plume rise, Δh. Especially when using h/sub e/ = h/sub s/ + Δh instead of h/sub s/ may reduce chi/sub max/ by a factor of anywhere from 4 to infinity. Factors to be considered in making plume rise predictions are discussed

  20. Radiation hazards

    Rausch, L.

    1979-01-01

    On a scientific basis and with the aid of realistic examples, the author gives a popular introduction to an understanding and judgment of the public discussion over radiation hazards: Uses and hazards of X-ray examinations, biological radiation effects, civilisation risks in comparison, origins and explanation of radiation protection regulations. (orig.) [de

  1. Whether and How Much to Give

    Petrovski, Erik

    This study evaluates whether factors known to foster charitable giving have a uniform influence on both (1) the decision to give and (2) the decision of how much to give. I establish that these two decisions are independent by dismissing the widely used Tobit model, which assumes a singe decision...

  2. Radiative inflation and dark energy

    Di Bari, Pasquale; King, Stephen F.; Luhn, Christoph; Merle, Alexander; Schmidt-May, Angnis

    2011-01-01

    We propose a model based on radiative symmetry breaking that combines inflation with dark energy and is consistent with the Wilkinson Microwave Anisotropy Probe 7-year regions. The radiative inflationary potential leads to the prediction of a spectral index 0.955 S < or approx. 0.967 and a tensor to scalar ratio 0.142 < or approx. r < or approx. 0.186, both consistent with current data but testable by the Planck experiment. The radiative symmetry breaking close to the Planck scale gives rise to a pseudo Nambu-Goldstone boson with a gravitationally suppressed mass which can naturally play the role of a quintessence field responsible for dark energy. Finally, we present a possible extra dimensional scenario in which our model could be realized.

  3. Mapping the imaginary of charitable giving

    Bajde, Domen

    2012-01-01

    The meaningfulness of charitable giving is largely owed to the imaginary conceptions that underpin this form of giving. Building on Taylor's notion of “social imaginary” and Godelier's work on “gift imaginary,” we theorize the imaginary of charitable giving. Through a combination of qualitative m...... across relatively stable assemblages of conceptions of poverty, donors, end-recipients and charitable giving. These assemblages are suggested to form a multifaceted imaginary that is both cultural (shared) and personal (individually performed).......The meaningfulness of charitable giving is largely owed to the imaginary conceptions that underpin this form of giving. Building on Taylor's notion of “social imaginary” and Godelier's work on “gift imaginary,” we theorize the imaginary of charitable giving. Through a combination of qualitative...

  4. The Practical Realities of Giving Back

    Ashton Bree Wesner

    2014-07-01

    Full Text Available In this thematic section, authors consider practical ways of giving back to the communities in which they conduct research. Each author discusses their evolving thoughts on how to give back in these practical ways. Some of these authors discuss giving back by giving money, food, rides, parties, and water bottles. In other cases, authors discuss giving back by creating jobs in the short or long term, grant writing, advocacy, and education. Story-telling is also a theme that many of the authors in this section discuss. For some authors, non-material forms of giving back are critical—simply maintaining social ties to the communities in which they worked, or sharing humor. The authors consider the utility of their attempts at giving back, and in some cases present their personal philosophy or guidelines on the subject.

  5. Radiation pneumonitis and fibrosis

    Shopova, V.; Salovsky, P.; Dancheva, V.

    2001-01-01

    The likelihood of toxic pulmonary lesions development as the result of radiation therapy for pulmonary carcinoma and breast cancer is discussed. Two possible forms of radiation induced changes are described, namely: classical radiation pneumonitis (RP) terminating with lung fibrosis circumscribed in the radiation zone, and sporadic RP giving rise to bilateral lymphatic alveolitis and manifestations outside the irradiation field. Attention is called to the fact that chemotherapy augments the risk of toxic lung damage occurrence. A number of markers for early RP diagnosis, including lactate dehydrogenase activity, KL-6, procollagen III, transforming growth factor β, C-reactive protein and partial oxygen pressure are listed. Therapeutic possibilities in coping with RP and pulmonary fibrosis are assayed. Apart from the standard therapeutic approach using corticosteroids and azatioprin, ideas are set forth concerning the application of some antioxidants, angiotensin converting enzyme inhibitors and γ-interferon. It is pointed out that radiation pneumonitis and pulmonary fibrosis treatment has an essential practical bearing on life expectancy and quality of life in a great number of cancer patients. (author)

  6. Rising from Plagiarising.

    Mohan, Muralee; Shetty, Deepthi; Shetty, Tripthi; Pandya, Kalpa

    2015-09-01

    Amongst the various forms of scientific misconduct, plagiarism has become increasingly prevalent in today's scientific process. Plagiarism is copying another author's ideas or words and portraying them as your own. Inclusion of another source's contents without giving credit to the source results in this unethical practice. Text derived directly from a source must always be put under quotation marks. Decreased awareness about plagiarism and what exactly constitutes it results in unintentional plagiarism. Plagiarism can be that of the ideas in which the author projects others' ideas as his own. It can also be that of the text also known as word to word plagiarism. Mosaic plagiarism is another form. Various guidelines formulated by esteemed scientific bodies such as World Association of Medical Editors, Committee on publication Ethics have provided an insight to authors, editors, publishers and peer reviewers into the practice of ethical writing. By understanding the true essence of plagiarism and following strict guidelines, it is certainly possible to avoid plagiarism. Various softwares are available to detect plagiarism. These softwares have a wide database which is scanned to reveal any kind of malpractice. If detected, it can have grave consequences causing not only retraction of the article but also loss of dignity. Failure to detect plagiarism reflects negatively on a journal. Originality is the true essence of any research or scientific paper. Any violation of this fact is an unforgivable offence. Thus, this review article attempts to cover the meaning, types, risks and ways to avoid plagiarism.

  7. Moessbauer radiation dynamical diffraction in crystals being subjected to the action of external variable fields

    Baryshevskii, V.G.; Skadorov, V.V.

    1986-01-01

    A dynamical theory is developed of the Moessbauer radiation diffraction by crystals being subjected to an variable external field action. Equations describing the dynamical diffraction by nonstationary crystals are obtained. It is shown that the resonant interaction between Moessbauer radiation and shift field induced in the crystal by a variable external field giving rise to an effective conversion of the incident wave into a wave with changed frequency. (author)

  8. Sound radiation quantities arising from a resilient circular radiator.

    Aarts, Ronald M; Janssen, Augustus J E M

    2009-10-01

    Power series expansions in ka are derived for the pressure at the edge of a radiator, the reaction force on the radiator, and the total radiated power arising from a harmonically excited, resilient, flat, circular radiator of radius a in an infinite baffle. The velocity profiles on the radiator are either Stenzel functions (1-(sigma/a)2)n, with sigma the radial coordinate on the radiator, or linear combinations of Zernike functions Pn(2(sigma/a)2-1), with Pn the Legendre polynomial of degree n. Both sets of functions give rise, via King's integral for the pressure, to integrals for the quantities of interest involving the product of two Bessel functions. These integrals have a power series expansion and allow an expression in terms of Bessel functions of the first kind and Struve functions. Consequently, many of the results in [M. Greenspan, J. Acoust. Soc. Am. 65, 608-621 (1979)] are generalized and treated in a unified manner. A foreseen application is for loudspeakers. The relation between the radiated power in the near-field on one hand and in the far field on the other is highlighted.

  9. Conditions needed to give meaning to rad-equivalence principle

    Latarjet, R.

    1980-01-01

    To legislate on mutagenic chemical pollution the problem to be faced is similar to that tackled about 30 years ago regarding pollution by ionizing radiations. It would be useful to benefit from the work of these 30 years by establishing equivalences, if possible, between chemical mutagens and radiations. Inevitable mutagenic pollutions are considered here, especially those associated with fuel based energy production. As with radiations the legislation must derive from a compromise between the harmful and beneficial effects of the polluting system. When deciding on tolerance doses it is necessary to safeguard the biosphere without inflicting excessive restrictions on industry and on the economy. The present article discusses the conditions needed to give meaning to the notion of rad-equivalence. Some examples of already established equivalences are given, together with the first practical consequences which emerge [fr

  10. How to Give a Good Talk?

    Legout , Arnaud

    2013-01-01

    Why should you give great talks? How to make great slides? How to give a talk? How to make good presentations?; 3rd cycle; Warning: download the powerpoint version to get animations. Animated slides in the PDF version may look cluttered.

  11. On Capillary Rise and Nucleation

    Prasad, R.

    2008-01-01

    A comparison of capillary rise and nucleation is presented. It is shown that both phenomena result from a balance between two competing energy factors: a volume energy and a surface energy. Such a comparison may help to introduce nucleation with a topic familiar to the students, capillary rise. (Contains 1 table and 3 figures.)

  12. Whether and How Much to Give

    Petrovski, Erik

    2017-01-01

    Charitable giving involves two seemingly distinct decisions: whether to give and how much to give. However, many researchers methodologically assume that these decisions are one and the same. The present study supports the argument that this is an incorrect assumption that is likely to generate...... misleading conclusions, in part, since the second decision is much more financial in nature than the first. The argument that charitable giving entails two distinct decisions is validated by empirically dismissing the prevailing Tobit model, which assumes a single decision, in favor of less restrictive two......-stage approaches: Cragg’s model and the Heckman model. Most importantly, it is shown that only by adopting a two-stage approach may it be uncovered that common determinants of charitable giving such as income and gender affect the two decisions at hand very differently. Data comes from a high-quality 2012 Danish...

  13. Nature and magnitude of the problem of spent radiation sources

    1991-09-01

    Various types of sealed radiation sources are widely used in industry, medicine and research. Virtually all countries have some sealed sources. The activity in the sources varies from kilobecquerels in consumer products to hundreds of pentabecquerels in facilities for food irradiation. Loss or misuse of sealed sources can give rise to accidents resulting in radiation exposure of workers and members of the general public, and can also give rise to extensive contamination of land, equipment and buildings. In extreme cases the exposure can be lethal. Problems of safety relating to spent radiation sources have been under consideration within the Agency for some years. The first objective of the project has been to prepare a comprehensive report reviewing the nature and background of the problem, also giving an overview of existing practices for the management of spent radiation sources. This report is the fulfilment of this first objective. The safe management of spent radiation sources cannot be studied in isolation from their normal use, so it has been necessary to include some details which are relevant to the use of radiation sources in general, although that area is outside the scope of this report. The report is limited to radiation sources made up of radioactive material. The Agency is implementing a comprehensive action plan for assistance to Member States, especially the developing countries, in all aspects of the safe management of spent radiation sources. The Agency is further seeking to establish regional or global solutions to the problems of long-term storage of spent radiation sources, as well as finding routes for the disposal of sources when it is not feasible to set up safe national solutions. The cost of remedial actions after an accident with radiation sources can be very high indeed: millions of dollars. If the Agency can help to prevent even one such single accident, the cost of its whole programme in this field would be more than covered. Refs

  14. Children are sensitive to norms of giving

    McAuliffe, K.; Raihani, N. J.; Dunham, Y.

    2017-01-01

    People across societies engage in costly sharing, but the extent of such sharing shows striking cultural variation, highlighting the importance of local norms in shaping generosity. Despite this acknowledged role for norms, it is unclear when they begin to exert their influence in development. Here we use a Dictator Game to investigate the extent to which 4- to 9-year-old children are sensitive to selfish (give 20%) and generous (give 80%) norms. Additionally, we varied whether children were ...

  15. System for the chemical professing and evaluation gives the residual thickness the gives detecting for gives appearances LR115 type 2

    Carrazana Gonzalez, J.A.; Tomas Zerquera, J.; Prendes Alonso, M.

    1998-01-01

    In this work the system is described built in the CPHR for the homogeneous chemical processing gives detecting gives nuclear appearances. A new developed method is exposed, based on the application gives the technique optical densitometry, for the precise estimate gives the residual thickness, gives detecting, gives nuclear appearances LR115 type 2 after the process gives chemical engraving

  16. Diagnostics from three rising submillimeter bursts

    Zhou, Ai-Hua; Li, Jian-Ping; Wang, Xin-Dong

    2016-01-01

    In this paper we investigate three novel rising submillimeter (THz) bursts that occurred sequentially in Super Active Region NOAA 10486. The average rising rate of the flux density above 200 GHz is only 20 sfu GHz −1 (corresponding to spectral index α of 1.6) for the THz spectral components of the 2003 October 28 and November 4 bursts, but it attained values of 235 sfu GHz −1 (α = 4.8) in the 2003 November 2 burst. The steeply rising THz spectrum can be produced by a population of highly relativistic electrons with a low-energy cutoff of 1 MeV, but it only requires a low-energy cutoff of 30 keV for the two slowly rising THz bursts, via gyrosynchrotron (GS) radiation based on our numerical simulations of burst spectra in the magnetic dipole field case. The electron density variation is much larger in the THz source than in the microwave (MW) source. It is interesting that the THz source radius decreased by 20%–50% during the decay phase for the three events, but the MW source increased by 28% for the 2003 November 2 event. In the paper we will present a formula that can be used to calculate the energy released by ultrarelativistic electrons, taking the relativistic correction into account for the first time. We find that the energy released by energetic electrons in the THz source exceeds that in the MW source due to the strong GS radiation loss in the THz range, although the modeled THz source area is 3–4 orders smaller than the modeled MW source one. The total energies released by energetic electrons via the GS radiation in radio sources are estimated, respectively, to be 5.2 × 10 33 , 3.9 × 10 33 and 3.7 × 10 32 erg for the October 28, November 2 and 4 bursts, which are 131, 76 and 4 times as large as the thermal energies of 2.9 × 10 31 , 2.1 × 10 31 and 5.2 × 10 31 erg estimated from soft X-ray GOES observations. (paper)

  17. The Effect of Media on Charitable Giving and Volunteering: Evidence from the "Give Five" Campaign

    Yoruk, Baris K.

    2012-01-01

    Fundraising campaigns advertised via mass media are common. To what extent such campaigns affect charitable behavior is mostly unknown, however. Using giving and volunteering surveys conducted biennially from 1988 to 1996, I investigate the effect of a national fundraising campaign, "Give Five," on charitable giving and volunteering patterns. The…

  18. The giving standard: conditional cooperation in the case of charitable giving

    P. Wiepking (Pamala); M. Heijnen (Merijn)

    2011-01-01

    textabstractIn this study, we make a first attempt to investigate the mechanisms of conditional cooperation in giving outside experiments, using retrospective survey data on charitable giving (the Giving the Netherlands Panel Study 2005 (GINPS05, 2005 ; N  = 1474)). Our results show that in the case

  19. Radiative properties of clouds

    Twomey, S.

    1993-01-01

    The climatic effects of condensation nuclei in the formation of cloud droplets and the subsequent role of the cloud droplets as contributors to the planetary short-wave albedo is emphasized. Microphysical properties of clouds, which can be greatly modified by the degree of mixing with cloud-free air from outside, are discussed. The effect of clouds on visible radiation is assessed through multiple scattering of the radiation. Cloudwater or ice absorbs more with increasing wavelength in the near-infrared region, with water vapor providing the stronger absorption over narrower wavelength bands. Cloud thermal infrared absorption can be solely related to liquid water content at least for shallow clouds and clouds in the early development state. Three-dimensional general circulation models have been used to study the climatic effect of clouds. It was found for such studies (which did not consider variations in cloud albedo) that the cooling effects due to the increase in planetary short-wave albedo from clouds were offset by heating effects due to thermal infrared absorption by the cloud. Two permanent direct effects of increased pollution are discussed in this chapter: (a) an increase of absorption in the visible and near infrared because of increased amounts of elemental carbon, which gives rise to a warming effect climatically, and (b) an increased optical thickness of clouds due to increasing cloud droplet number concentration caused by increasing cloud condensation nuclei number concentration, which gives rise to a cooling effect climatically. An increase in cloud albedo from 0.7 to 0.87 produces an appreciable climatic perturbation of cooling up to 2.5 K at the ground, using a hemispheric general circulation model. Effects of pollution on cloud thermal infrared absorption are negligible

  20. Thinkers and feelers: Emotion and giving.

    Corcoran, Katie E

    2015-07-01

    Voluntary organizations, such as religious congregations, ask their members to contribute money as a part of membership and rely on these contributions for their survival. Yet often only a small cadre of members provides the majority of the contributions. Past research on congregational giving focuses on cognitive rational processes, generally neglecting the role of emotion. Extending Collins' (2004) interaction ritual theory, I predict that individuals who experience positive emotions during religious services will be more likely to give a higher proportion of their income to their congregation than those who do not. Moreover, I argue that this effect will be amplified in congregational contexts characterized by high aggregate levels of positive emotion, strictness, dense congregational networks, and expressive rituals. Using data from the 2001 U.S. Congregational Life Survey and multilevel modeling, I find support for several of these hypotheses. The findings suggest that both cognitive and emotional processes underlie congregational giving. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. Conscientious refusals and reason-giving.

    Marsh, Jason

    2014-07-01

    Some philosophers have argued for what I call the reason-giving requirement for conscientious refusal in reproductive healthcare. According to this requirement, healthcare practitioners who conscientiously object to administering standard forms of treatment must have arguments to back up their conscience, arguments that are purely public in character. I argue that such a requirement, though attractive in some ways, faces an overlooked epistemic problem: it is either too easy or too difficult to satisfy in standard cases. I close by briefly considering whether a version of the reason-giving requirement can be salvaged despite this important difficulty. © 2013 John Wiley & Sons Ltd.

  2. Spectral and spatial shaping of Smith-Purcell radiation

    Remez, Roei; Shapira, Niv; Roques-Carmes, Charles; Tirole, Romain; Yang, Yi; Lereah, Yossi; Soljačić, Marin; Kaminer, Ido; Arie, Ady

    2017-12-01

    The Smith-Purcell effect, observed when an electron beam passes in the vicinity of a periodic structure, is a promising platform for the generation of electromagnetic radiation in previously unreachable spectral ranges. However, most of the studies of this radiation were performed on simple periodic gratings, whose radiation spectrum exhibits a single peak and its higher harmonics predicted by a well-established dispersion relation. Here, we propose a method to shape the spatial and spectral far-field distribution of the radiation using complex periodic and aperiodic gratings. We show, theoretically and experimentally, that engineering multiple peak spectra with controlled widths located at desired wavelengths is achievable using Smith-Purcell radiation. Our method opens the way to free-electron-driven sources with tailored angular and spectral responses, and gives rise to focusing functionality for spectral ranges where lenses are unavailable or inefficient.

  3. Radiation levels at CERN's injectors and their impact on electronic equipment

    AUTHOR|(SzGeCERN)649218; Brugger, Markus

    2013-01-01

    Electronic devices operating in hostile radiation environments, such as those found close to high-energy particle accelerators, can suffer from different types of radiation induced failures. At CERN, the mixed particle and energy radiation fields present at the Large Hadron Collider (LHC) and its injector chain can give rise to both stochastic and cumulative effects causing radiation induced failures of exposed electronics and materials, thus directly impacting components and system lifetimes, as well as maintenance requirements. With its original focus on the LHC, the Radiation to Electronics (R2E) project has been successfully implementing mitigation actions in order to avoid accelerator downtime due to radiation induced failures on active electronics. In a next step, the emphasis is put on CERN's injector chain, collecting the respective available information about radiation levels, the definition of additional monitoring requirements and a critical analysis of present and future equipment installations. T...

  4. The economic impact of giving up nuclear power in France

    Carnot, N.; Gallon, St.

    2001-01-01

    French nuclear plants will have to be shut down in the 2020's. Electricite de France (EDF) could replace them by either nuclear or gas-fired plants. Choosing the latter would lead to an increase in Green House Gases (GHG) emissions and to a rise of EDF's generation costs. In 2020, the price of electricity in Europe will be determined by a competitive market. Therefore, a rise of EDF's generation costs will mainly depress its operating profit (and slightly increase the market's price). Giving up nuclear power in 2020 would consequently lead to a fall of EDF's value and would penalize its shareholders, the State. On a macro-economic scale, the shock on the production cost of electricity would lead to a 0,5 to 1,0 percentage point drop of GDP (depending on the hypotheses). Structural unemployment would rise by 0,3 to 0,6 percentage point. The model used to find these results does not take into account the risk of nuclear accidents nor the uncertainty on the costs of nuclear waste disposal. On the other hand, gas-price is assumed to be low, and the costs of gas-fired generation do not integrate the risk premium due to gas-price volatility. In conclusion, the best choice on both micro and macro scales, consists in extending the life of current nuclear plants (if such an extension is authorised by safety regulators). These plants would be financially-amortized, produce electricity at a very competitive cost and emit no GHG. Furthermore, extending the life of current nuclear plants will defer any irreversible commitment on their replacement. The necessary decision could therefore be taken later on, with more information on the cost of alternative generation technologies and their efficiency. (author)

  5. Termination of Commercial Contracts by giving Notice

    Edlund, Hans Henrik

    2008-01-01

    Some long-term contracts are brought to an end if one of the parties gives notice. Usually, such a step is not considered a breach of contract. It causes the contract to end in accordance with the contract. When no express rules cover the situation, it is often not entirely clear whether or not t...

  6. Children are sensitive to norms of giving.

    McAuliffe, Katherine; Raihani, Nichola J; Dunham, Yarrow

    2017-10-01

    People across societies engage in costly sharing, but the extent of such sharing shows striking cultural variation, highlighting the importance of local norms in shaping generosity. Despite this acknowledged role for norms, it is unclear when they begin to exert their influence in development. Here we use a Dictator Game to investigate the extent to which 4- to 9-year-old children are sensitive to selfish (give 20%) and generous (give 80%) norms. Additionally, we varied whether children were told how much other children give (descriptive norm) or what they should give according to an adult (injunctive norm). Results showed that children generally gave more when they were exposed to a generous norm. However, patterns of compliance varied with age. Younger children were more likely to comply with the selfish norm, suggesting a licensing effect. By contrast, older children were more influenced by the generous norm, yet capped their donations at 50%, perhaps adhering to a pre-existing norm of equality. Children were not differentially influenced by descriptive or injunctive norms, suggesting a primacy of norm content over norm format. Together, our findings indicate that while generosity is malleable in children, normative information does not completely override pre-existing biases. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. They Make Space and Give Time

    ... Resonance – Journal of Science Education; Volume 3; Issue 3. They Make Space and Give Time The Engineer as Poet. Gangan Prathap. Book Review Volume 3 ... Author Affiliations. Gangan Prathap1. National Aerospace Laboratories and the Jawaharlal Nehru Centre for Advanced Scientific Research in Bangalore.

  8. Bidding to give in the field

    Onderstal, Sander; Schram, Arthur J. H. C.; Soetevent, Adriaan R.

    In a door-to-door fundraising field experiment, we study the impact of fundraising mechanisms on charitable giving. We approached about 4500 households, each participating in an all-pay auction, a lottery, a non-anonymous voluntary contribution mechanism (VCM), or an anonymous VCM. In contrast to

  9. Bidding to give in the field

    Onderstal, S.; Schram, A.J.H.C.; Soetevent, A.R.

    2013-01-01

    In a door-to-door fundraising field experiment, we study the impact of fundraising mechanisms on charitable giving. We approached about 4500 households, each participating in an all-pay auction, a lottery, a non-anonymous voluntary contribution mechanism (VCM), or an anonymous VCM. In contrast to

  10. Why healthcare workers give prelacteal feeds.

    Akuse, R M; Obinya, E A

    2002-08-01

    Because prelacteal feeds can adversely affect breastfeeding, UNICEF/WHO discourage their use unless medically indicated. The study was carried out to determine the proportion of healthcare workers who routinely give prelacteal feeds, and their reasons for doing so; further, to determine whether any differences exist between medically and non-medically trained healthcare workers in their administration of prelacteal feeds. Survey. Primary, secondary and tertiary health facilities in Kaduna township Nigeria. Of 1100 healthcare workers sampled, 747 (68%) responded. Of these 80% had received medical training, 20% had not. Use of a pretested validated questionnaire. Large proportions of both medical and non-medically trained healthcare workers stated they routinely give prelacteal feeds (doctors, 68.2%; nurses, 70.2%; and non-medical, 73.6%). However their reasons for doing so differed significantly (P=0.00001). Nurses gave mainly for perceived breast milk insufficiency, doctors for prevention of dehydration, hypoglycaemia and neonatal jaundice and non-medical staff to prepare the gastrointestinal tract for digestion and to quench thirst. Most healthcare workers (medical and non-medical) routinely and unnecessarily give prelacteal feeds. Therefore training and retraining programmes in lactation management are necessary and must include non-medical staff. These programmes, while emphasizing the danger of giving prelacteal feeds, must deal with the misconceptions of each group. Deliberate efforts have to be made to incorporate clinical training in breastfeeding in curricula of Schools of Medicine and Nursing.

  11. Asian American Giving to US Higher Education

    Tsunoda, Kozue

    2010-01-01

    Asian Americans have had significant impacts on and within mainstream US society, and their great efforts and gifts in the name of charitable causes are no exception. This study aims to examine perceptions within American university development offices about Asian American giving to US higher education. The article begins with a literature review…

  12. Radiation pattern of open ended waveguide in air core surrounded by annular plasma column

    Sharma, D.R.; Verma, J.S.

    1977-01-01

    Radiation pattern of open ended waveguide excited in circular symmetric mode (TM 01 ) in an air core having central conductor and surrounded by an annular plasma column is studied. The field distribution at the open end of the waveguide is considered to be equivalent to the vector sum of magnetic current rings of various radii, ranging from the outer radius of the inner conductor to the inner radius of the outer conductor of the waveguide at the open end. The radiation field is obtained as a vector sum of field components due to individual rings of current. Such a configuration gives rise to multiple narrow radiation beams away from the critical angle. (author)

  13. Medical standards for radiation workers

    Rae, S.

    1977-01-01

    The Council of the European Communities in its Directive of June 1, 1976 has laid down revised basic safety standards for the health protection of the general public and workers against the danger of ionising radiation. The Directive requires each Member State of the Community 'for the guidance of medical practitioners.....to draw up a list, which need not be exhaustive, of the criteria which should be taken into account when judging a worker's fitness to be exposed to ionising radiation'. Medical officers with current responsibility for radiation workers in the U.K. therefore met recently for informal exploratory discussion at the National Radiological Protection Board's headquarters, and an account is given of the views expressed there about the composition of the required 'list', and the possibility of standardizing the procedure adopted. Consideration was given to the objectives of medical examinations, the form of examination, and specific conditions which may give rise to difficulty in making a fitness assessment. These conditions are skin abnormalities, blood abnormalities, cataract, pregnancy, and psychological and psychiatric conditions. It was concluded that the medical examination of radiation workers, including blood examinations, are of value to the extent that they form part of any good general occupational health practice. The promulgation of the Euratom Directive has provided an opportunity for reviewing and standardising procedures for medical surveillance in the light of current knowledge concerning average occupational radiation doses and dose-response relationships. (U.K.)

  14. Radiation protection in veterinary medicine

    1991-01-01

    Diagnostic radiology is an essential part of present-day veterinary practice. The need for radiation protection exists because occupational exposure to ionizing radiation can result in deleterious effects that may manifest themselves not only in exposed individuals but in their descendants as well. These are respectively called somatic and genetic effects. Somatic effects are characterized by observable changes occurring in the body organs of the exposed individual. These changes may appear from within a few hours to many years later, depending on the amount and duration of exposure of the individual. In veterinary medicine, the possibility that anyone may be exposed to enough radiation to create somatic effect is extremely remote. Genetic effects are more a cause for concern at the lower doses used in veterinary radiology. Although the radiation doses may be small and appear to cause no observable damage, the probability of chromosomal damage in the germ cells, with the consequence of mutations, does exist. These mutations may give rise to genetic defects and therefore make these doses significant when applied to a large number of individuals. There are two main aspects of the problem to be considered. First, personnel working with X-ray equipment must be protected from excessive exposure to radiation during their work. Secondly, personnel in the vicinity of veterinary X-ray facilities and the general public require adequate protection

  15. Radiation medicine

    1991-01-01

    This booklet has been produced by UKAEA and the Marie Curie Memorial Foundation to give some basic information about what radiation is and how it is used in day to day diagnosis and treatment. It will be of interest to people undergoing treatment, their relatives and friends, and anyone who wants to know more about this important area. After a brief historical introduction the booklet explains what radiation is, the natural and man-made sources of radiation, how it is produced and how X-rays are used in medical diagnosis and treatment. The radiation protection measures taken and safety standards followed are mentioned. (author)

  16. Synchrotron radiation

    Farge, Y.

    1982-01-01

    Synchrotron radiation is produced by electrons accelerated near the velocity of light in storage rings, which are used for high energy Physics experiments. The radiation light exhibits a wide spread continuous spectrum ranging from 01 nanometre to radiofrequency. This radiation is characterized by high power (several kilowatts) and intense brightness. The paper recalls the emission laws and the distinctive properties of the radiation, and gives some of the numerous applications in research, such as molecular spectroscopy, X ray diffraction by heavy proteins and X ray microlithography in LVSI circuit making [fr

  17. The Rise of Blog Nation

    Lum, Lydia

    2005-01-01

    This article reports on the growth of blogs in popular culture, and the fact that they are becoming more widely accepted in the media industry. The rise and popularity of blogs--short for "Web logs"--are causing journalism educators to overhaul their teachings. In fact, blogging's influence varies from one university program to the next, just like…

  18. Finding Rising and Falling Words

    Tjong Kim Sang, E.

    2016-01-01

    We examine two different methods for finding rising words (among which neologisms) and falling words (among which archaisms) in decades of magazine texts (millions of words) and in years of tweets (billions of words): one based on correlation coefficients of relative frequencies and time, and one

  19. How to give a good talk.

    Alon, Uri

    2009-10-23

    We depend on talks to communicate our work, and we spend much of our time as audience members in talks. However, few scientists are taught the well-established principles of giving good talks. Here, I describe how to prepare, present, and answer questions in a scientific talk. We will see how a talk prepared with a single premise and delivered with good eye contact is clear and enjoyable.

  20. Rise, stagnation, and rise of Danish women's life expectancy

    Lindahl-Jacobsen, Rune; Rau, Roland; Jeune, Bernard

    2016-01-01

    Health conditions change from year to year, with a general tendency in many countries for improvement. These conditions also change from one birth cohort to another: some generations suffer more adverse events in childhood, smoke more heavily, eat poorer diets, etc., than generations born earlier...... favor forecasts that hinge on cohort differences. We use a combination of age decomposition and exchange of survival probabilities between countries to study the remarkable recent history of female life expectancy in Denmark, a saga of rising, stagnating, and now again rising lifespans. The gap between...... female life expectancy in Denmark vs. Sweden grew to 3.5 y in the period 1975-2000. When we assumed that Danish women born 1915-1945 had the same survival probabilities as Swedish women, the gap remained small and roughly constant. Hence, the lower Danish life expectancy is caused by these cohorts...

  1. Role-modeling and conversations about giving in the socialization of adolescent charitable giving and volunteering.

    Ottoni-Wilhelm, Mark; Estell, David B; Perdue, Neil H

    2014-01-01

    This study investigated the relationship between the monetary giving and volunteering behavior of adolescents and the role-modeling and conversations about giving provided by their parents. The participants are a large nationally-representative sample of 12-18 year-olds from the Panel Study of Income Dynamics' Child Development Supplement (n = 1244). Adolescents reported whether they gave money and whether they volunteered. In a separate interview parents reported whether they talked to their adolescent about giving. In a third interview, parents reported whether they gave money and volunteered. The results show that both role-modeling and conversations about giving are strongly related to adolescents' giving and volunteering. Knowing that both role-modeling and conversation are strongly related to adolescents' giving and volunteering suggests an often over-looked way for practitioners and policy-makers to nurture giving and volunteering among adults: start earlier, during adolescence, by guiding parents in their role-modeling of, and conversations about, charitable giving and volunteering. Copyright © 2013 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

  2. The new German radiation protection ordinance

    Pfeffer, W.; Weimer, G.

    2003-01-01

    According to European law, the Basic Safety Standards (BSS) published by the European Council in 1996 and the Council Directive on health protection of individuals against dangers of ionising radiation in relation to medical exposure had to be transferred into national law within due time. In 2001 the new Ordinance for the Implementation of the Euratom Guidelines on Radiation Protection] was published, which replaces the old Radiation Protection Ordinance. The new German Ordinance adapts the European Directive to German law, covering the general principles but even giving more details in many fields of radiation protection. The BSS scope certainly is much broader than the prescriptions important for the field of radiation protection in nuclear power plants. According to the scope of this workshop on occupational exposure in nuclear power plants - and as the BSS most probably will be quite familiar to all of you - after a short general overview on relevant contents of the German Ordinance, this presentation will focus on the main issues important in the operation of NPP and especially on some areas which may give rise to necessary changes caused by the new Ordinance. (A.L.B.)

  3. Give and Take in Dictator Games

    Cappelen, Alexander W.; Nielsen, Ulrik Haagen; Sørensen, Erik Ø.

    2014-01-01

    It has been shown that participants in the dictator game are less willing to give money to the other participant when their choice set also includes the option to take money. We examine whether this effect is due to the choice set providing a signal about entitlements in a setting where...... entitlements initially may be considered unclear. We find that the share of positive transfers depends on the choice set even when there is no uncertainty about entitlements, and that this choice-set effect is robust across a heterogenous group of participants recruited from the general adult population...

  4. Correction of incomplete charge collection in CdTe detectors using the correlation with the rise time distribution

    Horovitz, Yossi.

    1994-01-01

    Experimentally and theoretically it was found that there is a correlation between tile pulse rise time and the amount of charge that is collected in the detector contacts. As the rise time becomes longer less charge is collected. In this thesis it has been proven that one can find from this correlation, with the aid of a mathematical function, the theoretical amount of charge that has to be collected in the contacts if no trapping took place. This mathematical function called the correction function, f(t), is dependent on the rise time and the material quality (the trap concentration). In order to find the correction function, a computer, simulation was written. This computer program simulates, based on a phenomenological theoretical model, the charge collection in the detector. This model depends on three parameters (for the holes and for the electrons) that characterized the charge collection quality of the detector. The parameters are: the mean free time to be trapped, the detrapping time and the transit time that depends on the electric field. By a comparison between the simulation output and experimental data, these parameters were found. The correction function was found to be linear with rise time. This conclusion is confirmed experimentally. In this work experiments have been carried out that measured the correlation between two parameters. These experiments measured, for each photon that interacts with the detector, the pulse rise time and the pulse amplitude. A computer program accepts these spectra and substitute each element in the correction function and corrects for the incomplete charge collection. It was found that the correction function does not depend on the energy of the radiation source and source-detector geometry but depends on the material quality. The application of the correction function to the two dimensional spectra gives a correction of tens of percents in charge collection and provides an improvement in the resolution and the peak

  5. Response of single bacterial cells to stress gives rise to complex history dependence at the population level

    Mathis, Roland; Ackermann, Martin

    2016-01-01

    Most bacteria live in ever-changing environments where periods of stress are common. One fundamental question is whether individual bacterial cells have an increased tolerance to stress if they recently have been exposed to lower levels of the same stressor. To address this question, we worked with the bacterium Caulobacter crescentus and asked whether exposure to a moderate concentration of sodium chloride would affect survival during later exposure to a higher concentration. We found that the effects measured at the population level depended in a surprising and complex way on the time interval between the two exposure events: The effect of the first exposure on survival of the second exposure was positive for some time intervals but negative for others. We hypothesized that the complex pattern of history dependence at the population level was a consequence of the responses of individual cells to sodium chloride that we observed: (i) exposure to moderate concentrations of sodium chloride caused delays in cell division and led to cell-cycle synchronization, and (ii) whether a bacterium would survive subsequent exposure to higher concentrations was dependent on the cell-cycle state. Using computational modeling, we demonstrated that indeed the combination of these two effects could explain the complex patterns of history dependence observed at the population level. Our insight into how the behavior of single cells scales up to processes at the population level provides a perspective on how organisms operate in dynamic environments with fluctuating stress exposure. PMID:26960998

  6. A versatile class of cell surface directional motors gives rise to gliding motility and sporulation in Myxococcus xanthus.

    Morgane Wartel

    2013-12-01

    Full Text Available Eukaryotic cells utilize an arsenal of processive transport systems to deliver macromolecules to specific subcellular sites. In prokaryotes, such transport mechanisms have only been shown to mediate gliding motility, a form of microbial surface translocation. Here, we show that the motility function of the Myxococcus xanthus Agl-Glt machinery results from the recent specialization of a versatile class of bacterial transporters. Specifically, we demonstrate that the Agl motility motor is modular and dissociates from the rest of the gliding machinery (the Glt complex to bind the newly expressed Nfs complex, a close Glt paralogue, during sporulation. Following this association, the Agl system transports Nfs proteins directionally around the spore surface. Since the main spore coat polymer is secreted at discrete sites around the spore surface, its transport by Agl-Nfs ensures its distribution around the spore. Thus, the Agl-Glt/Nfs machineries may constitute a novel class of directional bacterial surface transporters that can be diversified to specific tasks depending on the cognate cargo and machinery-specific accessories.

  7. Identification and Targeting of Candidate Pre-Existing Lurker Cells that Give Rise to Castration-Resistant Prostate Cancer

    2015-10-01

    castration-resistance of each subset in humans. We also measured castration-resistance of isolated subsets in vitro in the presence or absence of DHT in...microns). In vitro growth in the absence of DHT also demonstrates castration-resistant properties of the intermediate/luminal progenitor cells...subsets without DHT compared to DHT -containing media, demonstrating castration-resistance). 4 4) other achievements: We found that tumors

  8. Hello handsome! Male's facial attractiveness gives rise to female's fairness bias in Ultimatum Game scenarios-An ERP study.

    Ma, Qingguo; Qian, Da; Hu, Linfeng; Wang, Lei

    2017-01-01

    The current study delineated how male proposers' facial attractiveness affect female responders' fairness considerations and their subsequent decision outcome during the Ultimatum Game (UG). Event Related Potentials (ERPs) were recorded from 17 female subjects, who played the role as responders and had to decide whether to accept offers from either attractive or unattractive male proposers. Behavioral data (Acceptance Ratio and Response time) revealed that, more offers were accepted from attractive-face conditions; subjects typically responded quicker to unfair offers from unattractive proposers as compared with slower to unfair offers from attractive proposers. The ERP data demonstrated similar N2 amplitudes elicited by both attractive and unattractive faces, and a larger early frontal LPP elicited by the attractive faces compared with unattractive ones, but no significant differences of both late posterior LPP and typical parietal LPP amplitudes were observed between these two face conditions, which was different from our previous study with similar paradigm but male participants. The results suggest that, in comparison to males, females might not experience the potential attention bias towards unattractive opposite-sex faces and are less likely to possess an enhanced processing and evaluation of those faces. This phenomenon might be explained by endogenous gender differences in mate preference. The feedback-related negativity (FRN) and P300 responses during an offer presentation were further measured in both attractive-face and unattractive-face conditions and the results demonstrated that the amplitudes elicited by fair and unfair offers were not statistically different in the former condition, but were different in the latter condition. More specifically, unfair offers generated larger FRN and smaller P300 than fair ones in the unattractive-face condition. Findings suggest that, although females tend to possess less salient evaluation of male's facial attractiveness, the attractiveness of male proposers would still attenuate female responders' fairness consideration during the UG.

  9. Protein Crowding in Lipid Bilayers Gives Rise to Non-Gaussian Anomalous Lateral Diffusion of Phospholipids and Proteins

    Jeon, J. H.; Javanainen, M.; Martinez-Seara, Hector; Metzler, R.; Vattulainen, I.

    2016-01-01

    Roč. 6, č. 2 (2016), č. článku 021006. ISSN 2160-3308 Institutional support: RVO:61388963 Keywords : protein crowding * membranes * simulations * diffusion * non-Gaussian anomalous diffusion Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 12.789, year: 2016 http://journals.aps.org/prx/abstract/10.1103/PhysRevX.6.021006

  10. Scorpion β-toxin interference with NaV channel voltage sensor gives rise to excitatory and depressant modes

    Leipold, Enrico; Borges, Adolfo

    2012-01-01

    Scorpion β toxins, peptides of ∼70 residues, specifically target voltage-gated sodium (NaV) channels to cause use-dependent subthreshold channel openings via a voltage–sensor trapping mechanism. This excitatory action is often overlaid by a not yet understood depressant mode in which NaV channel activity is inhibited. Here, we analyzed these two modes of gating modification by β-toxin Tz1 from Tityus zulianus on heterologously expressed NaV1.4 and NaV1.5 channels using the whole cell patch-clamp method. Tz1 facilitated the opening of NaV1.4 in a use-dependent manner and inhibited channel opening with a reversed use dependence. In contrast, the opening of NaV1.5 was exclusively inhibited without noticeable use dependence. Using chimeras of NaV1.4 and NaV1.5 channels, we demonstrated that gating modification by Tz1 depends on the specific structure of the voltage sensor in domain 2. Although residue G658 in NaV1.4 promotes the use-dependent transitions between Tz1 modification phenotypes, the equivalent residue in NaV1.5, N803, abolishes them. Gating charge neutralizations in the NaV1.4 domain 2 voltage sensor identified arginine residues at positions 663 and 669 as crucial for the outward and inward movement of this sensor, respectively. Our data support a model in which Tz1 can stabilize two conformations of the domain 2 voltage sensor: a preactivated outward position leading to NaV channels that open at subthreshold potentials, and a deactivated inward position preventing channels from opening. The results are best explained by a two-state voltage–sensor trapping model in that bound scorpion β toxin slows the activation as well as the deactivation kinetics of the voltage sensor in domain 2. PMID:22450487

  11. Misrepresentation of neuroscience data might give rise to misleading conclusions in the media: the case of attention deficit hyperactivity disorder.

    Francois Gonon

    Full Text Available BACKGROUND: There is often a huge gap between neurobiological facts and firm conclusions stated by the media. Data misrepresentation in the conclusions and summaries of neuroscience articles might contribute to this gap. METHODOLOGY/PRINCIPAL FINDINGS: Using the case of attention deficit hyperactivity disorder (ADHD, we identified three types of misrepresentation. The first relies on prominent inconsistencies between results and claimed conclusions and was observed in two scientific reports dealing with ADHD. Only one out of the 61 media articles echoing both scientific reports adequately described the results and, thus questioned the claimed conclusion. The second type of misrepresentation consists in putting a firm conclusion in the summary while raw data that strongly limit the claim are only given in the results section. To quantify this misrepresentation we analyzed the summaries of all articles asserting that polymorphisms of the gene coding for the D4 dopaminergic receptor are associated with ADHD. Only 25 summaries out of 159 also mentioned that this association confers a small risk. This misrepresentation is also observed in most media articles reporting on ADHD and the D4 gene. The third misrepresentation consists in extrapolating basic and pre-clinical findings to new therapeutic prospects in inappropriate ways. Indeed, analysis of all ADHD-related studies in mice showed that 23% of the conclusions were overstated. The frequency of this overstatement was positively related with the impact factor of the journal. CONCLUSION/SIGNIFICANCE: Data misrepresentations are frequent in the scientific literature dealing with ADHD and may contribute to the appearance of misleading conclusions in the media. In synergy with citation distortions and publication biases they influence social representations and bias the scientific evidence in favor of the view that ADHD is primarily caused by biological factors. We discuss the social consequences and the causes of data misrepresentations and suggest a few corrective actions.

  12. Misrepresentation of neuroscience data might give rise to misleading conclusions in the media: the case of attention deficit hyperactivity disorder.

    Gonon, Francois; Bezard, Erwan; Boraud, Thomas

    2011-01-31

    There is often a huge gap between neurobiological facts and firm conclusions stated by the media. Data misrepresentation in the conclusions and summaries of neuroscience articles might contribute to this gap. Using the case of attention deficit hyperactivity disorder (ADHD), we identified three types of misrepresentation. The first relies on prominent inconsistencies between results and claimed conclusions and was observed in two scientific reports dealing with ADHD. Only one out of the 61 media articles echoing both scientific reports adequately described the results and, thus questioned the claimed conclusion. The second type of misrepresentation consists in putting a firm conclusion in the summary while raw data that strongly limit the claim are only given in the results section. To quantify this misrepresentation we analyzed the summaries of all articles asserting that polymorphisms of the gene coding for the D4 dopaminergic receptor are associated with ADHD. Only 25 summaries out of 159 also mentioned that this association confers a small risk. This misrepresentation is also observed in most media articles reporting on ADHD and the D4 gene. The third misrepresentation consists in extrapolating basic and pre-clinical findings to new therapeutic prospects in inappropriate ways. Indeed, analysis of all ADHD-related studies in mice showed that 23% of the conclusions were overstated. The frequency of this overstatement was positively related with the impact factor of the journal. Data misrepresentations are frequent in the scientific literature dealing with ADHD and may contribute to the appearance of misleading conclusions in the media. In synergy with citation distortions and publication biases they influence social representations and bias the scientific evidence in favor of the view that ADHD is primarily caused by biological factors. We discuss the social consequences and the causes of data misrepresentations and suggest a few corrective actions.

  13. A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development.

    Philip J Byrd

    2016-03-01

    Full Text Available Patients with biallelic truncating mutations in PALB2 have a severe form of Fanconi anaemia (FA-N, with a predisposition for developing embryonal-type tumours in infancy. Here we describe two unusual patients from a single family, carrying biallelic PALB2 mutations, one truncating, c.1676_1677delAAinsG;(p.Gln559ArgfsTer2, and the second, c.2586+1G>A; p.Thr839_Lys862del resulting in an in frame skip of exon 6 (24 amino acids. Strikingly, the affected individuals did not exhibit the severe developmental defects typical of FA-N patients and initially presented with B cell non-Hodgkin lymphoma. The expressed p.Thr839_Lys862del mutant PALB2 protein retained the ability to interact with BRCA2, previously unreported in FA-N patients. There was also a large increased chromosomal radiosensitivity following irradiation in G2 and increased sensitivity to mitomycin C. Although patient cells were unable to form Rad51 foci following exposure to either DNA damaging agent, U2OS cells, in which the mutant PALB2 with in frame skip of exon 6 was induced, did show recruitment of Rad51 to foci following damage. We conclude that a very mild form of FA-N exists arising from a hypomorphic PALB2 allele.

  14. Assess the dominant circumstances and factors giving rise to accidents in the gold and platinum mining industries

    Ashworth, SGE

    1994-03-01

    Full Text Available This report summarises both the statistical analysis of accident data and detailed accident case studies in attempt to make a complete conclusions of what causes the accidents in gold and platinum mines. And also discusses the recommendations...

  15. Biochemical Analysis of Two Single Mutants that Give Rise to a Polymorphic G6PD A-Double Mutant

    Edson Jiovany Ramírez-Nava

    2017-10-01

    Full Text Available Glucose-6-phosphate dehydrogenase (G6PD is a key regulatory enzyme that plays a crucial role in the regulation of cellular energy and redox balance. Mutations in the gene encoding G6PD cause the most common enzymopathy that drives hereditary nonspherocytic hemolytic anemia. To gain insights into the effects of mutations in G6PD enzyme efficiency, we have investigated the biochemical, kinetic, and structural changes of three clinical G6PD variants, the single mutations G6PD A+ (Asn126AspD and G6PD Nefza (Leu323Pro, and the double mutant G6PD A− (Asn126Asp + Leu323Pro. The mutants showed lower residual activity (≤50% of WT G6PD and displayed important kinetic changes. Although all Class III mutants were located in different regions of the three-dimensional structure of the enzyme and were not close to the active site, these mutants had a deleterious effect over catalytic activity and structural stability. The results indicated that the G6PD Nefza mutation was mainly responsible for the functional and structural alterations observed in the double mutant G6PD A−. Moreover, our study suggests that the G6PD Nefza and G6PD A− mutations affect enzyme functions in a similar fashion to those reported for Class I mutations.

  16. Identification and Targeting of Candidate Preexisting Lurker Cells That Give Rise to Castration-Resistant Prostate Cancer

    2016-10-01

    highly (4- to 5-fold) en- riched for organoid formation compared to CD38hi luminal cellsCell Reports 17, 2596–2606, December 6, 2016 2597 Figure 1... riched in CD38lo cells (Figure 3A) but has not been previously associated with PIA. In tissue sections, PSCA expression was observed more commonly in...without a mesenchymal niche . Nature 459, 262–265.2606 Cell Reports 17, 2596–2606, December 6, 2016Sboner, A., Demichelis, F., Calza, S., Pawitan, Y., Setlur

  17. Congenital unilateral absence of the upper extremity may give rise to a specific kind of thoracolumbar curve.

    Olgun, Z Deniz; Demirkiran, Gokhan; Polly, David; Yazici, Muharrem

    2018-03-01

    There is an increased incidence of scoliosis in patients with congenital malformations of the upper extremity even in the absence of overt vertebral abnormalities. In this case series, we summarize the curve characteristics of four patients presenting to two spine surgery clinics with unilateral amelia or phocomelia and a progressive scoliotic curve with the apex on the side of deficiency. All patients required orthopedic intervention for their curves. Amelia and phocomelia are severe congenital malformations of the upper limb affecting trunk balance and, conceivably, causing scoliosis with the absence of counterbalancing weight on the affected side. The combination of upper limb absence and same-sided scoliosis in these patients may provide a clue of the mechanical factors causing scoliosis in other disorders. In this article, we attempt to define this exceptional deformity, theorize on its etiology, and draw attention to this particular combination of problems. Case series; Level IV.

  18. Impact of Technology on Work : Technical Functionalities that Give Rise to New Job Designs in Industry 4.0

    Waschull, S.; Bokhorst, J.A.C.; Wortmann, J.C.; Lödding, Hermann; Riedel, Ralph; Thoben, Klaus-Dieter; Von Cieminski, Gregor; Kiritsis, Dimitris

    2017-01-01

    With rapid advancements in the application of Industry 4.0 technologies throughout industries, a collection of different views on its potential implications for workers are emerging. Various authors agree that these technologies and their application in manufacturing systems is structurally

  19. Acquired IFNγ resistance impairs anti-tumor immunity and gives rise to T-cell-resistant melanoma lesions

    Sucker, Antje; Zhao, Fang; Pieper, Natalia; Heeke, Christina; Maltaner, Raffaela; Stadtler, Nadine; Real, Birgit; Bielefeld, Nicola; Howe, Sebastian; Weide, Benjamin; Gutzmer, Ralf; Utikal, Jochen; Loquai, Carmen; Gogas, Helen; Klein-Hitpass, Ludger; Zeschnigk, Michael; Westendorf, Astrid M.; Trilling, Mirko; Horn, Susanne; Schilling, Bastian; Schadendorf, Dirk; Griewank, Klaus G.; Paschen, Annette

    2017-01-01

    Melanoma treatment has been revolutionized by antibody-based immunotherapies. IFNγ secretion by CD8+ T cells is critical for therapy efficacy having anti-proliferative and pro-apoptotic effects on tumour cells. Our study demonstrates a genetic evolution of IFNγ resistance in different melanoma patient models. Chromosomal alterations and subsequent inactivating mutations in genes of the IFNγ signalling cascade, most often JAK1 or JAK2, protect melanoma cells from anti-tumour IFNγ activity. JAK1/2 mutants further evolve into T-cell-resistant HLA class I-negative lesions with genes involved in antigen presentation silenced and no longer inducible by IFNγ. Allelic JAK1/2 losses predisposing to IFNγ resistance development are frequent in melanoma. Subclones harbouring inactivating mutations emerge under various immunotherapies but are also detectable in pre-treatment biopsies. Our data demonstrate that JAK1/2 deficiency protects melanoma from anti-tumour IFNγ activity and results in T-cell-resistant HLA class I-negative lesions. Screening for mechanisms of IFNγ resistance should be considered in therapeutic decision-making. PMID:28561041

  20. Coffee bean extracts rich and poor in kahweol both give rise to elevation of liver enzymes in healthy volunteers

    Schouten Evert G

    2004-07-01

    Full Text Available Abstract Background Coffee oil potently raises serum cholesterol levels in humans. The diterpenes cafestol and kahweol are responsible for this elevation. Coffee oil also causes elevation of liver enzyme levels in serum. It has been suggested that cafestol is mainly responsible for the effect on serum cholesterol levels and that kahweol is mainly responsible for the effect on liver enzyme levels. The objective of this study was to investigate whether coffee oil that only contains a minute amount of kahweol indeed does not cause elevation of liver enzyme levels. Methods The response of serum alanine aminotransferase (ALAT and aspartate aminotransferase (ASAT to Robusta coffee oil (62 mg/day cafestol, 1.6 mg/day kahweol was measured in 18 healthy volunteers. Results After nine days one subject was taken off Robusta oil treatment due to an ALAT level of 3.6 times the upper limit of normal (ULN. Another two subjects stopped treatment due to other reasons. After 16 days another two subjects were taken off Robusta oil treatment. One of those subjects had levels of 5.8 ULN for ALAT and 2.0 ULN for ASAT; the other subject had an ALAT level of 12.4 ULN and an ASAT level of 4.7 ULN. It was then decided to terminate the study. The median response of subjects to Robusta oil after 16 days was 0.27 ULN (n = 15, 25th,75th percentile: 0.09;0.53 for ALAT and 0.06 ULN (25th,75th percentile -0.06;0.22 for ASAT. Conclusions We conclude that the effect on liver enzyme levels of coffee oil containing hardly any kahweol is similar to that of coffee oil containing high amounts of kahweol. Therefore it is unlikely that kahweol is the component of coffee oil that is responsible for the effect. Furthermore, we conclude that otherwise unexplained elevation of liver enzyme levels observed in patients might be caused by a switch from consumption of filtered coffee to unfiltered coffee.

  1. Engineered photoproteins that give rise to photosynthetically-incompetent bacteria are effective as photovoltaic materials for biohybrid photoelectrochemical cells.

    Liu, Juntai; Friebe, Vincent M; Swainsbury, David J K; Crouch, Lucy I; Szabo, David A; Frese, Raoul N; Jones, Michael R

    2018-04-17

    Reaction centre/light harvesting proteins such as the RCLH1X complex from Rhodobacter sphaeroides carry out highly quantum-efficient conversion of solar energy through ultrafast energy transfer and charge separation, and these pigment-proteins have been incorporated into biohybrid photoelectrochemical cells for a variety of applications. In this work we demonstrate that, despite not being able to support normal photosynthetic growth of Rhodobacter sphaeroides, an engineered variant of this RCLH1X complex lacking the PufX protein and with an enlarged light harvesting antenna is unimpaired in its capacity for photocurrent generation in two types of bio-photoelectrochemical cells. Removal of PufX also did not impair the ability of the RCLH1 complex to act as an acceptor of energy from synthetic light harvesting quantum dots. Unexpectedly, the removal of PufX led to a marked improvement in the overall stability of the RCLH1 complex under heat stress. We conclude that PufX-deficient RCLH1 complexes are fully functional in solar energy conversion in a device setting and that their enhanced structural stability could make them a preferred choice over their native PufX-containing counterpart. Our findings on the competence of RCLH1 complexes for light energy conversion in vitro are discussed with reference to the reason why these PufX-deficient proteins are not capable of light energy conversion in vivo.

  2. Population Density Modulates Drug Inhibition and Gives Rise to Potential Bistability of Treatment Outcomes for Bacterial Infections.

    Jason Karslake

    2016-10-01

    Full Text Available The inoculum effect (IE is an increase in the minimum inhibitory concentration (MIC of an antibiotic as a function of the initial size of a microbial population. The IE has been observed in a wide range of bacteria, implying that antibiotic efficacy may depend on population density. Such density dependence could have dramatic effects on bacterial population dynamics and potential treatment strategies, but explicit measures of per capita growth as a function of density are generally not available. Instead, the IE measures MIC as a function of initial population size, and population density changes by many orders of magnitude on the timescale of the experiment. Therefore, the functional relationship between population density and antibiotic inhibition is generally not known, leaving many questions about the impact of the IE on different treatment strategies unanswered. To address these questions, here we directly measured real-time per capita growth of Enterococcus faecalis populations exposed to antibiotic at fixed population densities using multiplexed computer-automated culture devices. We show that density-dependent growth inhibition is pervasive for commonly used antibiotics, with some drugs showing increased inhibition and others decreased inhibition at high densities. For several drugs, the density dependence is mediated by changes in extracellular pH, a community-level phenomenon not previously linked with the IE. Using a simple mathematical model, we demonstrate how this density dependence can modulate population dynamics in constant drug environments. Then, we illustrate how time-dependent dosing strategies can mitigate the negative effects of density-dependence. Finally, we show that these density effects lead to bistable treatment outcomes for a wide range of antibiotic concentrations in a pharmacological model of antibiotic treatment. As a result, infections exceeding a critical density often survive otherwise effective treatments.

  3. Different selection pressures give rise to distinct ethnic phenomena : a functionalist framework with illustrations from the Peruvian Altiplano.

    Moya, Cristina; Boyd, Robert

    2015-03-01

    Many accounts of ethnic phenomena imply that processes such as stereotyping, essentialism, ethnocentrism, and intergroup hostility stem from a unitary adaptation for reasoning about groups. This is partly justified by the phenomena's co-occurrence in correlational studies. Here we argue that these behaviors are better modeled as functionally independent adaptations that arose in response to different selection pressures throughout human evolution. As such, different mechanisms may be triggered by different group boundaries within a single society. We illustrate this functionalist framework using ethnographic work from the Quechua-Aymara language boundary in the Peruvian Altiplano. We show that different group boundaries motivate different ethnic phenomena. For example, people have strong stereotypes about socioeconomic categories, which are not cooperative units, whereas they hold fewer stereotypes about communities, which are the primary focus of cooperative activity. We also show that, despite the cross-cultural importance of ethnolinguistic boundaries, the Quechua-Aymara linguistic distinction does not strongly motivate any of these intergroup processes.

  4. Reversible conformational transition gives rise to 'zig-zag' temperature dependence of the rate constant of irreversible thermoinactivation of enzymes.

    Levitsky VYu; Melik-Nubarov, N S; Siksnis, V A; Grinberg VYa; Burova, T V; Levashov, A V; Mozhaev, V V

    1994-01-15

    We have obtained unusual 'zig-zag' temperature dependencies of the rate constant of irreversible thermoinactivation (k(in)) of enzymes (alpha-chymotrypsin, covalently modified alpha-chymotrypsin, and ribonuclease) in a plot of log k(in) versus reciprocal temperature (Arrhenius plot). These dependencies are characterized by the presence of both ascending and descending linear portions which have positive and negative values of the effective activation energy (Ea), respectively. A kinetic scheme has been suggested that fits best for a description of these zig-zag dependencies. A key element of this scheme is the temperature-dependent reversible conformational transition of enzyme from the 'low-temperature' native state to a 'high-temperature' denatured form; the latter form is significantly more stable against irreversible thermoinactivation than the native enzyme. A possible explanation for a difference in thermal stabilities is that low-temperature and high-temperature forms are inactivated according to different mechanisms. Existence of the suggested conformational transition was proved by the methods of fluorescence spectroscopy and differential scanning calorimetry. The values of delta H and delta S for this transition, determined from calorimetric experiments, are highly positive; this fact underlies a conclusion that this heat-induced transition is caused by an unfolding of the protein molecule. Surprisingly, in the unfolded high-temperature conformation, alpha-chymotrypsin has a pronounced proteolytic activity, although this activity is much smaller than that of the native enzyme.

  5. Generation and characterization of p53 null transformed hepatic progenitor cells: oval cells give rise to hepatocellular carcinoma.

    Dumble, Melissa L; Croager, Emma J; Yeoh, George C T; Quail, Elizabeth A

    2002-03-01

    Oval cells are bipotential liver stem cells able to differentiate into hepatocytes and bile duct epithelia. In normal adult liver oval cells are quiescent, existing in low numbers around the periportal region, and proliferate following severe, prolonged liver trauma. There is evidence implicating oval cells in the development of hepatocellular carcinoma, and hence the availability of an immortalized oval cell line would be invaluable for the study of liver cell lineage differentiation and carcinogenesis. A novel approach in the generation of cell lines is the use of the p53 knockout mouse. Absence of p53 allows a cell to cycle past the normal Hayflick limit, rendering it immortalized, although subsequent genetic alterations are thought necessary for transformation. p53 knockout mice were fed a choline-deficient, ethionine-supplemented diet, previously shown to increase oval cell numbers in wild-type mice. The oval cells were isolated by centrifugal elutriation and maintained in culture. Colonies of hepatic cells were isolated and characterized with respect to phenotype, growth characteristics and tumorigenicity. Analysis of gene expression by Northern blotting and immunocytochemistry suggests they are oval-like cells by virtue of albumin and transferrin expression, as well as the oval cell markers alpha fetoprotein, M(2)-pyruvate kinase and A6. Injection into athymic nude mice shows the cell lines are capable of forming tumors which phenotypically resemble hepatocellular carcinoma. Thus, the use of p53 null hepatic cells successfully generated immortalized and tumorigenic hepatic stem cell lines. The results presented support the idea that deleting p53 allows immortalization and contributes to the transformation of the oval-like cell lines. Further, the tumorigenic status of the cell lines is direct evidence for the participation of oval cells in the formation of hepatocellular carcinoma.

  6. A homozygote splice site PMS2 mutation as cause of Turcot syndrome gives rise to two different abnormal transcripts.

    Sjursen, Wenche; Bjørnevoll, Inga; Engebretsen, Lars F; Fjelland, Kristine; Halvorsen, Tore; Myrvold, Helge E

    2009-01-01

    Turcot syndrome is a rare, inherited disease predisposing of tumours in the central nerve system and in the colorectal system. This report describes a Turcot patient with an extraordinary clinical history. The patient is still alive at the age of 43. She was operated at the age of 10 by brain tumour and at the age of 16 by colorectal cancer. She has since then been treated for multiple cancers (gastrointestinal, endometrial, basal cell carcinomas), and removal of adenomatous polyps at several occasions. The aim of this work was to investigate if there was any specific genotype that explains her remarkable clinical history. Microsatellite instability and immunohistochemistry analysis for four DNA mismatch repair proteins were performed. DNA mutation analysis was done for genes involved in polyposis and mismatch repair by denaturing high performance liquid chromatography and sequencing. cDNA analysis was carried out for the mismatch repair gene PMS2. The patients genotype was found to be a homozygous splice site mutation in the PMS2 gene, c.989-1G

  7. Gdf5 progenitors give rise to fibrocartilage cells that mineralize via hedgehog signaling to form the zonal enthesis.

    Dyment, Nathaniel A; Breidenbach, Andrew P; Schwartz, Andrea G; Russell, Ryan P; Aschbacher-Smith, Lindsey; Liu, Han; Hagiwara, Yusuke; Jiang, Rulang; Thomopoulos, Stavros; Butler, David L; Rowe, David W

    2015-09-01

    The sequence of events that leads to the formation of a functionally graded enthesis is not clearly defined. The current study demonstrates that clonal expansion of Gdf5 progenitors contributes to linear growth of the enthesis. Prior to mineralization, Col1+ cells in the enthesis appose Col2+ cells of the underlying primary cartilage. At the onset of enthesis mineralization, cells at the base of the enthesis express alkaline phosphatase, Indian hedgehog, and ColX as they mineralize. The mineralization front then extends towards the tendon midsubstance as cells above the front become encapsulated in mineralized fibrocartilage over time. The hedgehog (Hh) pathway regulates this process, as Hh-responsive Gli1+ cells within the developing enthesis mature from unmineralized to mineralized fibrochondrocytes in response to activated signaling. Hh signaling is required for mineralization, as tissue-specific deletion of its obligate transducer Smoothened in the developing tendon and enthesis cells leads to significant reductions in the apposition of mineralized fibrocartilage. Together, these findings provide a spatiotemporal map of events - from expansion of the embryonic progenitor pool to synthesis of the collagen template and finally mineralization of this template - that leads to the formation of the mature zonal enthesis. These results can inform future tendon-to-bone repair strategies to create a mechanically functional enthesis in which tendon collagen fibers are anchored to bone through mineralized fibrocartilage. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. An Unusual Ligand Coordination Gives Rise to a New Family of Rhodium Metalloinsertors with Improved Selectivity and Potency

    2015-01-01

    Rhodium metalloinsertors are octahedral complexes that bind DNA mismatches with high affinity and specificity and exhibit unique cell-selective cytotoxicity, targeting mismatch repair (MMR)-deficient cells over MMR-proficient cells. Here we describe a new generation of metalloinsertors with enhanced biological potency and selectivity, in which the complexes show Rh–O coordination. In particular, it has been found that both Δ- and Λ-[Rh(chrysi)(phen)(DPE)]2+ (where chrysi =5,6 chrysenequinone diimmine, phen =1,10-phenanthroline, and DPE = 1,1-di(pyridine-2-yl)ethan-1-ol) bind to DNA containing a single CC mismatch with similar affinities and without racemization. This is in direct contrast with previous metalloinsertors and suggests a possible different binding disposition for these complexes in the mismatch site. We ascribe this difference to the higher pKa of the coordinated immine of the chrysi ligand in these complexes, so that the complexes must insert into the DNA helix with the inserting ligand in a buckled orientation; spectroscopic studies in the presence and absence of DNA along with the crystal structure of the complex without DNA support this assignment. Remarkably, all members of this new family of compounds have significantly increased potency in a range of cellular assays; indeed, all are more potent than cisplatin and N-methyl-N′-nitro-nitrosoguanidine (MNNG, a common DNA-alkylating chemotherapeutic agent). Moreover, the activities of the new metalloinsertors are coupled with high levels of selective cytotoxicity for MMR-deficient versus proficient colorectal cancer cells. PMID:25254630

  9. A Hebbian learning rule gives rise to mirror neurons and links them to control theoretic inverse models

    Hanuschkin, A.; Ganguli, S.; Hahnloser, R. H. R.

    2013-01-01

    Mirror neurons are neurons whose responses to the observation of a motor act resemble responses measured during production of that act. Computationally, mirror neurons have been viewed as evidence for the existence of internal inverse models. Such models, rooted within control theory, map-desired sensory targets onto the motor commands required to generate those targets. To jointly explore both the formation of mirrored responses and their functional contribution to inverse models, we develop...

  10. Unfolding transitions in myosin give rise to the double-hyperbolic force-velocity relation in muscle

    Nielsen, Bjørn Gilbert

    2003-01-01

    This work presents an extension to a recent model of muscle contraction that was based on entropic elasticity (Nielsen 2002 J. Theor Biol. 219 99-119). By using entropic elasticity as the origin of muscle force, various possibilities emerge that can account for the presence of the double......-hyperbolic force-velocity relation in muscle that was observed by Edman (1988 J. Physiol. 404 301-21). In the present work, it will be argued that a slight change (elongation) of the contour length of the entropic springs involved in their high-force regions is sufficient to produce such a double...

  11. Identification and Targeting of Candidate Pre-Existing Lurker Cells that Give Rise to Castration-Resistant Prostate Cancer

    2014-10-01

    carcinoma with different signaling pathways characteristic of each histo- logical pattern. eIF4E-driven protein translation pathway is el - evated in...and 4EBP1 ( Epitomics ); Histone H3, AKT, and p4EBP1 (Thr37/46); pErk1/ 2 (T202/Y204), pSTAT3 (Y705), Sox2, MTA1, Src, and pSrc (Y416) (Cell Signaling

  12. The experience gives the Cuban program with children gives territories affected by the Chernobyl accident

    Garcia, O.; Llanes, R.

    1998-01-01

    From 1990 it works in Cuba a program destined to offer medical attention you specialize and to develop a plan sanatoria gives rehabilitation with children provided the different areas affected by the contamination radioactive resultant to the Chernobyl accident

  13. Potential application of a centralized solar water-heating system for a high-rise residential building in Hong Kong

    Chow, T.T.; Fong, K.F.; Chan, A.L.S.; Lin, Z.

    2006-01-01

    There is a growing, government-led trend of applying renewable energy in Hong Kong. One area of interest lies in the wider use of solar-energy systems. The worldwide fast development of building-integrated solar technology has prompted the design alternative of fixing the solar panels on the external facades of buildings. In Hong Kong, high-rise buildings are found everywhere in the urban districts. How to make full use of the vertical facades of these buildings to capture the most solar radiation can be an important area in the technology promotion. In this numerical study, the potential application of a centralized solar water-heating system in high-rise residence was evaluated. Arrays of solar thermal collectors, that occupied the top two-third of the south and west facades of a hypothetical high-rise residence, were proposed for supporting the domestic hot-water system. Based on typical meteorological data, it was found that the annual efficiency of the vertical solar collectors could reach 38.4% on average, giving a solar fraction of 53.4% and a payback period of 9.2 years. Since the solar collectors were able to reduce the heat transmission through the building envelope, the payback was in fact even shorter if the energy saving in air-conditioner operation was considered

  14. The Luxury of Igniting Change by Giving

    Llamas, Rosa; Uth Thomsen, Thyra

    2016-01-01

    This study investigates the phenomenon of luxury from a consumer perspective, by means of multisited phenomenological inquiry. The findings expand the pervasive view of luxury as accumulation of highly valued goods by offering a transformative perspective of luxury as transforming the life...... the giver with a sense of luxury in terms of pleasure, purpose, and connection with humankind. Thus, the findings not only extend the traditional conceptualization of luxury from having to giving, but also challenge current conceptualizations of sharing out as a non-reciprocal pro-social behavior...... by illustrating how ‘the luxury of giving’ relies on both pro-social and pro-ego consumption rationales, which implicitly include circular reciprocation....

  15. Giving Devices the Ability to Exercise Reason

    Thomas Keeley

    2008-10-01

    Full Text Available One of the capabilities that separates humans from computers has been the ability to exercise "reason / judgment". Computers and computerized devices have provided excellent platforms for following rules. Computer programs provide the scripts for processing the rules. The exercise of reason, however, is more of an image processing function than a function composed of a series of rules. The exercise of reason is more right brain than left brain. It involves the interpretation of information and balancing inter-related alternatives. This paper will discuss a new way to define and process information that will give devices the ability to exercise human-like reasoning and judgment. The paper will discuss the characteristics of a "dynamic graphical language" in the context of addressing judgment, since judgment is often required to adjust rules when operating in a dynamic environment. The paper will touch on architecture issues and how judgment is integrated with rule processing.

  16. Giving up nuclear energy. Obstacles, conditions, consequences

    Koegel-Dorfs, H.

    1990-01-01

    Life on this earth is not possible without using energy. The resources of the energies used so far are limited and their utilization carries certain risks which have now become obvious: climatic problems on the one hand, safety problems on the other. Chernobyl, Wackersdorf, tornados and population growth are issues mentioned all the time in the fight for the best solution. Even church synodes have spoken up and demanded to give up nuclear energy. The energy issue, however, has become a question of survival. This study, worked out by a group of scientists (natural science, energy science, lawyers, theologians) analyses the obstacles, conditions and consequences of such a step. The possible solution of rational energy utilization and substitution of energy services and regenerative energies is discussed in depth. The book concludes that problems can only be coped with if there is a feeling of joint responsibility and global social consensus. (orig./HP) [de

  17. Radiation sterilization of vitamins - studies on the radiolysis and radiation protection of vitamins in aqueous systems and the solid state

    Rao, K.N.; Moorthy, P.N.; Kishore, K.

    1978-01-01

    Radiation sterilization of pharmaceutical products may cause their radiation degradation and loss in their potency. Radiation degradation may even give rise to new products whose effects on the organisms could be different from the parent substances. Extent of radiolytic decomposition of vitamins thiamine, nicotinamide, riboflavine and pyridoxine was studied under controlled conditions so that either only the hydrated electrons (esub(aq)) or only hydrogen atom (H) and hydroxyl radical react with these molecules. Experiments were also conducted in which scavengers for these species were added to reduce radiolytic degradation of the vitamins. It was found that irradiation of vitamins in the frozen aqueous state and with addition of glucose reduces radiolytic degradation and their irradiation in dry solid state causes no detectable damage. The last finding indicates that the best method for radiation sterilization of vitamin preparations may be to irradiate the components in the dry solid state and then compound them together. (M.G.B.)

  18. Effects of Low Level Radiation exposure on Neurogenesis and Cognitive Function: Mechanisms and Prevention

    2005-09-01

    1 mental model in the old rat. Int. J. Radiat. Oncol. Biol. Phys., 31: 65-70, 1995. give rise to new nerons in the adult mammalian hippocampus. I...Morris water maze localized within a network , could significantly increase the and white noise and bright light used to motivate escape complexity and...irradiation. However, we cannot ex- can be incorporated into the hippocampal networks and/or elude the possibility that a more challenging version of the

  19. Radiative corrections to e+e- → W+W- in the Weinberg model

    Veltman, M.J.G.; Lemoine, M.

    1980-01-01

    The one-loop radiation corrections to the process e+e- ->W+W- are calculated in the Weinberg model. The corrections are computed in a c.m. energy range of 180-1000 GeV. The dependence on the Higgs mass is studied in detail; it is found that variations in the Higgs mass from 10-1000 GeV give rise

  20. Is sea-level rising?

    Unnikrishnan, A.S.

    correction in the estimation of trends obtained for tide gauge records. The altimeter data permits to prepare spatial maps of sea-level rise trends. We present a map prepared for the Indian Ocean (Figure 4) north of 10oS , which shows a fairly uniform... drawn information from research papers published by the author and report of the IPCC AR5 WG1 Chapter 13: Sea Level Changes, in which the author has served as a ‘Lead Author’. Figure1 is prepared using data from the University of Colorado. Nerem, R...

  1. Sea Level Rise Data Discovery

    Quach, N.; Huang, T.; Boening, C.; Gill, K. M.

    2016-12-01

    Research related to sea level rise crosses multiple disciplines from sea ice to land hydrology. The NASA Sea Level Change Portal (SLCP) is a one-stop source for current sea level change information and data, including interactive tools for accessing and viewing regional data, a virtual dashboard of sea level indicators, and ongoing updates through a suite of editorial products that include content articles, graphics, videos, and animations. The architecture behind the SLCP makes it possible to integrate web content and data relevant to sea level change that are archived across various data centers as well as new data generated by sea level change principal investigators. The Extensible Data Gateway Environment (EDGE) is incorporated into the SLCP architecture to provide a unified platform for web content and science data discovery. EDGE is a data integration platform designed to facilitate high-performance geospatial data discovery and access with the ability to support multi-metadata standard specifications. EDGE has the capability to retrieve data from one or more sources and package the resulting sets into a single response to the requestor. With this unified endpoint, the Data Analysis Tool that is available on the SLCP can retrieve dataset and granule level metadata as well as perform geospatial search on the data. This talk focuses on the architecture that makes it possible to seamlessly integrate and enable discovery of disparate data relevant to sea level rise.

  2. Maintaining clinical governance when giving telephone advice.

    Alazawi, William; Agarwal, Kosh; Suddle, Abid; Aluvihare, Varuna; Heneghan, Michael A

    2013-10-01

    Delivering excellent healthcare depends on accurate communication between professionals who may be in different locations. Frequently, the first point of contact with the liver unit at King's College Hospital (KCH) is through a telephone call to a specialist registrar or liver fellow, for whom no case notes are available in which to record information. The aim of this study was to improve the clinical governance of telephone referrals and to generate contemporaneous records that could be easily retrieved and audited. An electronic database for telephone referrals and advice was designed and made securely available to registrars in our unit. Service development in a tertiary liver centre that receives referrals from across the UK and Europe. Demographic and clinical data were recorded prospectively and analysed retrospectively. Data from 350 calls were entered during 5 months. The information included the nature and origin of the call (200 from 75 different institutions), disease burden and severity of disease among the patients discussed with KCH, and outcome of the call. The majority of cases were discussed with consultants or arrangements were made for formal review at KCH. A telephone referrals and advice database provides clinical governance, serves as a quality indicator and forms a contemporaneous record at the referral centre. Activity data and knowledge of disease burden help to tailor services to the needs of referrers and commissioners. We recommend implementation of similar models in other centres that give extramural verbal advice.

  3. Cultivating gratitude and giving through experiential consumption.

    Walker, Jesse; Kumar, Amit; Gilovich, Thomas

    2016-12-01

    Gratitude promotes well-being and prompts prosocial behavior. Here, we examine a novel way to cultivate this beneficial emotion. We demonstrate that 2 different types of consumption-material consumption (buying for the sake of having) and experiential consumption (buying for the sake of doing)-differentially foster gratitude and giving. In 6 studies we show that reflecting on experiential purchases (e.g., travel, meals out, tickets to events) inspires more gratitude than reflecting on material purchases (e.g., clothing, jewelry, furniture), and that thinking about experiences leads to more subsequent altruistic behavior than thinking about possessions. In Studies 1-2b, we use within-subject and between-subjects designs to test our main hypothesis: that people are more grateful for what they've done than what they have. Study 3 finds evidence for this effect in the real-world setting of online customer reviews: Consumers are more likely to spontaneously mention feeling grateful for experiences they have bought than for material goods they have bought. In our final 2 studies, we show that experiential consumption also makes people more likely to be generous to others. Participants who contemplated a significant experiential purchase behaved more generously toward anonymous others in an economic game than those who contemplated a significant material purchase. It thus appears that shifting spending toward experiential consumption can improve people's everyday lives as well as the lives of those around them. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  4. Giving what one should: explanations for the knowledge-behavior gap for altruistic giving.

    Blake, Peter R

    2018-04-01

    Several studies have shown that children struggle to give what they believe that they should: the so-called knowledge-behavior gap. Over a dozen recent Dictator Game studies find that, although young children believe that they should give half of a set of resources to a peer, they typically give less and often keep all of the resources for themselves. This article reviews recent evidence for five potential explanations for the gap and how children close it with age: self-regulation, social distance, theory of mind, moral knowledge and social learning. I conclude that self-regulation, social distance, and social learning show the most promising evidence for understanding the mechanisms that can close the gap. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. Effects of ionizing radiations on insects

    Goyffon, Max.

    1978-01-01

    The most traditional effects caused by irradiation are development and morphogenesis disorders since on the whole the sensitivity of the developing organism to ionizing radiations is all the greater as the growth rate is faster. During the development of higher insects two categories of cell divide: larval cells on the one hand, which differentiate immediately after segmentation and give rise to larval organisms, and embryonic cells on the other which divide actively to form various islets or imaginal discs destined, each to its own extent, to provide the organs of the adult. Two cell categories thus coexist in the larva, one undergoing differentiation and the other multiplication, the radiosensitivity of which will be quite different for this very reason and will account at least partly, where the lethal effect of ionizing radiations is concerned, for the results observed. Three chapters deal in turn with effects on longevity, on regeneration and restoration and on morphogenesis and development. Strong doses give rise beyond a certain threshold to the appearance of acute radiodermatitis; their clinical signs and different degrees of seriousness liken them to burns of a special type [fr

  6. Radiation exposure

    Dalton, L.K.

    1991-01-01

    The book gives accounts of some social and environmental impacts of the developing radiation industries, including the experiences of affected communities and individuals. Its structure is based on a division which has been made between nuclear and non-nuclear radiation sources, because they create distinctly different problems for environmental protection and so for public health policy. The emissions from electronic and electrical installations - the non-nuclear radiations - are dealt with in Part I. Emissions from radioactive substances - the nuclear radiations - are dealt with in Part II. Part III is for readers who want more detailed information about scientific basis of radiation-related biological changes and their associated health effects. 75 refs., 9 tabs., 7 figs., ills

  7. Plume rise measurements at Turbigo

    Anfossi, D

    1982-01-01

    This paper presents analyses of plume measurements obtained during that campaign by the ENEL ground-based Lidar. The five stacks of Turbigo Power Plant have different heights and emission parameters and their plumes usually combine, so a model for multiple sources was used to predict the plume rises. These predictions are compared with the observations. Measurements of sigma/sub v/ and sigma/sub z/ over the first 1000 m are compared with the curves derived from other observations in the Po Valley, using the no-lift balloon technique over the same range of downwind distance. Skewness and kurtosis distributions are shown, both along the vertical and the horizontal directions. In order to show the plume structure in more detail, we present two examples of Lidar-derived cross sections and the corresponding vertically and horizontally integrated concentration profiles.

  8. Superphenix set to rise again

    Dorozynski, A.

    1993-01-01

    Superphenix, France's seemingly jinxed fast breeder reactor, which has not produced a single kilowatt of energy in more than 3 years, looks set to rise up next year like the mythical bird it is named after. The $5 billion reactor, the largest fast breeder in the world, has just been given the seal of approval by a public commission ordered by the government to look at the pros and cons of restarting. It still has hoops to jump through: a safety check and approval from the ministries of industries and environment. But the consortium of French, Italian, and German power utilities that run the plant are confident they can get it running by next summer. The Superphenix that rises out of the ashes will, however, be a different species of bird from the one planned 20 years ago. The consortium plans to turn the reactor into a debreeder, one that will incinerate more plutonium than it produces and so eat into Europe's plutonium stockpile. Calculations by Superphenix staff and the Atomic Energy Commission indicate that a plutonivorous fast breeder could incinerate 15 to 25 kilograms of plutonium while producing 1 billion kilowatt-hours of electricity-scarcely enough to make a dent in the tonnes of plutonium produced by Electricite de France's reactors each year. The Superphenix consortium is anxious to get the reactor back on line. The annual cost of upkeep and repair of the idle plant and salaries for its 700 staff may reach $140 million this year, 20% more than if the plant was running normally. If restarted, the existing core and a second one ready on the shelf will generate electricity worth $1.3 billion

  9. Radiation protection limits and review procedure

    Dafauti, Sunita; Gopalakrishnan, R.K.; Pradeepkumar, K.S.

    2017-01-01

    The primary means of controlling radiation exposure in planned exposure situations in nuclear facilities/radiological laboratories are by good design of facilities, equipment, operating procedures and by ensuring appropriate training to all plant occupational workers. In planned exposure situations, exposure at some level can be expected to occur. For planned exposure situations, exposures are subject to control for ensuring that the specified dose limits for occupational exposure and those for public exposure are not exceeded and optimization is applied to attain the desired level of protection and safety. The person or organization responsible for any facility or activity that gives rise to radiation exposure should have the prime responsibility for protection and safety, which cannot be delegated

  10. Nearly degenerate neutrinos, supersymmetry and radiative corrections

    Casas, J.A.; Espinosa, J.R.; Ibarra, A.; Navarro, I.

    2000-01-01

    If neutrinos are to play a relevant cosmological role, they must be essentially degenerate with a mass matrix of the bimaximal mixing type. We study this scenario in the MSSM framework, finding that if neutrino masses are produced by a see-saw mechanism, the radiative corrections give rise to mass splittings and mixing angles that can accommodate the atmospheric and the (large angle MSW) solar neutrino oscillations. This provides a natural origin for the Δm 2 sol 2 atm hierarchy. On the other hand, the vacuum oscillation solution to the solar neutrino problem is always excluded. We discuss also in the SUSY scenario other possible effects of radiative corrections involving the new neutrino Yukawa couplings, including implications for triviality limits on the Majorana mass, the infrared fixed point value of the top Yukawa coupling, and gauge coupling and bottom-tau unification

  11. Giving in Europe : The state of research on giving in 20 European countries

    Hoolwerf, L.K.; Schuyt, T.N.M.

    2017-01-01

    This study is in intitial attempt to map philanthropy in Europe and presents a first overall estimation of the European philanthropic sector. Containing an overview of what we know about research on the philanthropy sector, it provides data and and assesment of the data on giving by households,

  12. Multi-layer planting as a strategy of greening the transitional space in high-rise buildings: A review

    Prihatmanti, Rani; Taib, Nooriati

    2018-03-01

    The issues regarding the rapid development in the urban have resulted in the increasing number of infrastructure built, including the high-rise buildings to accommodate the urban dwellers. Lack of greeneries due to the land limitation in the urban area has increased the surface radiation as well as the air temperature that leads to the Urban Heat Island (UHI) phenomena. Where urban land is limited, growing plants vertically could be a solution. Plants, which are widely known as one of the sustainability elements in the built environment could be integrated in building as a part of urban faming by growing edible plant species. This is also to address the food security issue in the urban as well as high-density cities. Since space is limited, the function of transitional space could be optimized for the green space. This paper explores the strategy of greening transitional space in the high-rise setting. To give a maximum impact in a limited space, multi-layer planting concept could be introduced. This concept is believed that multiple layers of plants could modify the microclimate, as well as the radiation to the building, compare to single layer plant. In addition to that, the method selected also determines the efficacy of the vertical greeneries. However, there are many other limitations related to the multi-layer planting method if installed in a transitional space that needs to be further studied. Despite its limitations, the application of vertical greeneries with multi-layer planting concept could be a promising solution for greening the limited space as well as improving the thermal comfort in the high-rise building.

  13. Quark radiation from LEP

    Cartwright, Susan

    1992-01-01

    Like any other electrically charged particles, quarks should give out electromagnetic radiation (photons) when they vibrate. One of the physics results from CERN's LEP collider is the first clear observation of this quark radiation from electron-positron collisions. At lower energies this radiation could only be inferred

  14. Radiation biology. Chapter 20

    Wondergem, J. [International Atomic Energy Agency, Vienna (Austria)

    2014-09-15

    Radiation biology (radiobiology) is the study of the action of ionizing radiations on living matter. This chapter gives an overview of the biological effects of ionizing radiation and discusses the physical, chemical and biological variables that affect dose response at the cellular, tissue and whole body levels at doses and dose rates relevant to diagnostic radiology.

  15. Quark radiation from LEP

    Cartwright, Susan

    1992-04-15

    Like any other electrically charged particles, quarks should give out electromagnetic radiation (photons) when they vibrate. One of the physics results from CERN's LEP collider is the first clear observation of this quark radiation from electron-positron collisions. At lower energies this radiation could only be inferred.

  16. Red Shift and Broadening of Backward Harmonic Radiation from Electron Oscillations Driven by Femtosecond Laser Pulse

    Tian Youwei; Yu Wei; Lu Peixiang; Senecha, Vinod K; Han, Xu; Deng Degang; Li Ruxin; Xu Zhizhan

    2006-01-01

    The characteristics of backward harmonic radiation due to electron oscillations driven by a linearly polarized fs laser pulse are analysed considering a single electron model. The spectral distributions of the electron's backward harmonic radiation are investigated in detail for different parameters of the driver laser pulse. Higher order harmonic radiations are possible for a sufficiently intense driving laser pulse. We have shown that for a realistic pulsed photon beam, the spectrum of the radiation is red shifted as well as broadened because of changes in the longitudinal velocity of the electrons during the laser pulse. These effects are more pronounced at higher laser intensities giving rise to higher order harmonics that eventually leads to a continuous spectrum. Numerical simulations have further shown that by increasing the laser pulse width the broadening of the high harmonic radiations can be controlled

  17. Large Volcanic Rises on Venus

    Smrekar, Suzanne E.; Kiefer, Walter S.; Stofan, Ellen R.

    1997-01-01

    Large volcanic rises on Venus have been interpreted as hotspots, or the surface manifestation of mantle upwelling, on the basis of their broad topographic rises, abundant volcanism, and large positive gravity anomalies. Hotspots offer an important opportunity to study the behavior of the lithosphere in response to mantle forces. In addition to the four previously known hotspots, Atla, Bell, Beta, and western Eistla Regiones, five new probable hotspots, Dione, central Eistla, eastern Eistla, Imdr, and Themis, have been identified in the Magellan radar, gravity and topography data. These nine regions exhibit a wider range of volcano-tectonic characteristics than previously recognized for venusian hotspots, and have been classified as rift-dominated (Atla, Beta), coronae-dominated (central and eastern Eistla, Themis), or volcano-dominated (Bell, Dione, western Eistla, Imdr). The apparent depths of compensation for these regions ranges from 65 to 260 km. New estimates of the elastic thickness, using the 90 deg and order spherical harmonic field, are 15-40 km at Bell Regio, and 25 km at western Eistla Regio. Phillips et al. find a value of 30 km at Atla Regio. Numerous models of lithospheric and mantle behavior have been proposed to interpret the gravity and topography signature of the hotspots, with most studies focusing on Atla or Beta Regiones. Convective models with Earth-like parameters result in estimates of the thickness of the thermal lithosphere of approximately 100 km. Models of stagnant lid convection or thermal thinning infer the thickness of the thermal lithosphere to be 300 km or more. Without additional constraints, any of the model fits are equally valid. The thinner thermal lithosphere estimates are most consistent with the volcanic and tectonic characteristics of the hotspots. Estimates of the thermal gradient based on estimates of the elastic thickness also support a relatively thin lithosphere (Phillips et al.). The advantage of larger estimates of

  18. Radiation self-polarization of electrons moving in a magnetic field. [Vector spin operator, relaxation time

    Bagrov, V G; Dorofeev, O F; Sokolov, A A; Ternov, I M; Khalilov, V R [Moskovskij Gosudarstvennyj Univ. (USSR)

    1975-03-11

    When electrons move in a magnetic field, synchrotron radiation gives rise to transitions accompanied by the electron spin reorientation. In this case, it is essential that the transition probability depends on the spin orientation; as a result electron polarization takes place with the spin orientation being predominantly opposite to the direction of the magnetic field. This effect has been called ''radiative self-polarization of electrons''. The present work is concerned with the question how the choice of the spin operator will affect the self-polarization degree and relaxation time. The problem has been solved for a vector spin operator.

  19. Experience and problems of the automated measuring and sorting of sealed radiation sources

    Shmidt, G.

    1979-01-01

    It has been shown that with the help of a serial device for samples changing and a mini-computer with a suitable software it is possible to organize the radioactivity measuring and sorting of sealed gamma-sources with activity in the microcuri region. Application of the computer permits to rise accuracy of the data on the radiation sources radioactivity, sorted according to the preset activity level groups and, in the casa of necessity, to perform the activity measurements with lower error. The method listed, gives the working-time economy of nearly 4 hours in measuring and sorting of some 500 sealed radiation sources [ru

  20. Rising prices squeeze gas marketer

    Lunan, D.

    2000-06-19

    Apollo Gas, a Toronto-based gas marketer, is considering options to enhance unit holder value, including sale of its 21,000 gas supply contracts, just weeks after it was forced out of the Alberta market by rising gas prices. Although the company had reported first quarter revenues of more than $15 million and earnings through that period of about $2.1 million, increases of 33 per cent and 38 per cent respectively over the same period in 1999, the company is resigned to the fact that such performance markers are not likely to be reached again in the foreseeable future, hence the decision to sell. About 95 per cent of Apollo's current transportation service volumes are matched to existing fixed-price supply contract which are due to expire in November 2000. After that, it is about 75 per cent matched for the balance of the term of its customer contracts (mostly five years). This means that the company is exposed to market prices that are likely to continue to increase. If this prediction holds true, Apollo would be forced to purchase the unhedged volumes of gas it needs to service its customers in the spot market at prices higher than prices the company is charging to its customers.

  1. Rising prices squeeze gas marketer

    Lunan, D.

    2000-01-01

    Apollo Gas, a Toronto-based gas marketer, is considering options to enhance unit holder value, including sale of its 21,000 gas supply contracts, just weeks after it was forced out of the Alberta market by rising gas prices. Although the company had reported first quarter revenues of more than $15 million and earnings through that period of about $2.1 million, increases of 33 per cent and 38 per cent respectively over the same period in 1999, the company is resigned to the fact that such performance markers are not likely to be reached again in the foreseeable future, hence the decision to sell. About 95 per cent of Apollo's current transportation service volumes are matched to existing fixed-price supply contract which are due to expire in November 2000. After that, it is about 75 per cent matched for the balance of the term of its customer contracts (mostly five years). This means that the company is exposed to market prices that are likely to continue to increase. If this prediction holds true, Apollo would be forced to purchase the unhedged volumes of gas it needs to service its customers in the spot market at prices higher than prices the company is charging to its customers

  2. Spectrum and isotropy of the submillimeter background radiation

    Muehlner, D.

    1977-01-01

    Two great astronomical discoveries have most shaped our present concept of the Big Bang universe. Like the Hubble recession of the galaxies, the discovery of the 3 0 K background radiation by Penzias and Wilson in 1965 has given rise to a line of research which is still very active today. Penzias and Wilson's universal microwave background at 7 cm was immediately interpreted by R.H. Dicke's group at Princeton as coming from the primordial fireball of incandescent plasma which filled the universe for the million years or so after its explosive birth. This interpretation gives rise to two crucial predictions as to the nature of the background radiation. Its spectrum should be thermal even after having been red shifted by a factor of approximately 1000 by the expansion of the universe, and the radiation should be isotropic - assuming that the universe itself is isotropic. If the background radiation is indeed from the primordial fireball it affords us the only direct view at the very young universe. This paper deals with the spectrum and then the isotropy of the background radiation, with emphasis on high frequency or submillimeter measurements. Prospects for the future are discussed briefly. (Auth.)

  3. Radiation oncology

    Anon.

    1977-01-01

    The Radiation Oncology Division has had as its main objectives both to operate an academic training program and to carry out research on radiation therapy of cancer. Since fiscal year 1975, following a directive from ERDA, increased effort has been given to research. The research activities have been complemented by the training program, which has been oriented toward producing radiation oncologists, giving physicians short-term experience in radiation oncology, and teaching medical students about clinical cancer and its radiation therapy. The purpose of the research effort is to improve present modalities of radiation therapy of cancer. As in previous years, the Division has operated as the Radiation Oncology Program of the Department of Radiological Sciences of the University of Puerto Rico School of Medicine. It has provided radiation oncology support to patients at the University Hospital and to academic programs of the University of Puerto Rico Medical Sciences Campus. The patients, in turn, have provided the clinical basis for the educational and research projects of the Division. Funding has been primarily from PRNC (approx. 40%) and from National Cancer Institute grants channeled through the School of Medicine (approx. 60%). Special inter-institutional relationships with the San Juan Veterans Administration Hospital and the Metropolitan Hospital in San Juan have permitted inclusion of patients from these institutions in the Division's research projects. Medical physics and radiotherapy consultations have been provided to the Radiotherapy Department of the VA Hospital

  4. Rethinking the social and cultural dimensions of charitable giving

    Bajde, Domen

    2009-01-01

    -giving and focuses on charitable gifts as an emblem of postmodern gift-giving to distant others. Historical evidence and sociological theory on postmodern solidarity are combined to shed light on the fluid duality of contemporary giving and the importance of the imaginary in charitable giving. The outlined socially...... symbolic dimensions of charitable giving are critically examined in light of postmodern consumer culture and the recent social corporate responsibility trends. By openly engaging the proposed complexities of gift-giving, our vocabulary and understanding of postmodern giving can be revised so as to invite...

  5. Radiofrequency radiation

    Elder, J.A.; Czerski, P.A.; Stuchly, M.A.; Mild, K.H.; Sheppard, A.R.

    1989-01-01

    High-level radiofrequency radiation is a source of thermal energy that carries all of the known implications of heating for biological systems, including burns, temporary and permanent changes in reproduction, cataracts, and death. In general, no changes in chromosomes, DNA or the reproductive potential of animals exposed to RF radiation have been reported in the absence of significant rises in temperature, though there are limited data on DNA and chromosomal changes at non-thermal levels. Human data are currently limited and do not provide adequate information about the relationship between prolonged low-level RF radiation exposure and increased mortality or morbidity, including cancer incidence. In epidemiological studies and clinical reports of RF effects in man, the problems of quantification are numerous and include uncertainties about ''dose'', health effects, latent periods, dose-response relationships, and interactions with other physical or chemical agents. 228 refs, 6 figs, 2 tabs

  6. Radiation damage

    Heijne, Erik H M; CERN. Geneva

    1998-01-01

    a) Radiation damage in organic materials. This series of lectures will give an overview of radiation effects on materials and components frequently used in accelerator engineering and experiments. Basic degradation phenomena will be presented for organic materials with comprehensive damage threshold doses for commonly used rubbers, thermoplastics, thermosets and composite materials. Some indications will be given for glass, scintillators and optical fibres. b) Radiation effects in semiconductor materials and devices. The major part of the time will be devoted to treat radiation effects in semiconductor sensors and the associated electronics, in particular displacement damage, interface and single event phenomena. Evaluation methods and practical aspects will be shown. Strategies will be developed for the survival of the materials under the expected environmental conditions of the LHC machine and detectors. I will describe profound revolution in our understanding of black holes and their relation to quantum me...

  7. Radiation curing

    Wendrinsky, J.

    1987-04-01

    In the beginning of the seventies the two types of radiation sources applied in industrial processes, electron radiation and UV, had been given rather optimistic forecasts. While UV could succeed in the field of panel and film coating, electron radiation curing seems to gain success in quite new fields of manufacturing. The listing of the suggested applications of radiation curing and a comparison of both advantages and disadvantages of this technology are followed by a number of case studies emphasizing the features of these processes and giving some examplary calculations. The data used for the calculations should provide an easy calculation of individual manufacturing costs if special production parameters, investment or energy costs are employed. (Author)

  8. Should a carbon tax rise or fall over time?

    Ulph, Alistair; Ulph, David; Pezzey, John

    1991-01-01

    A carbon tax has been proposed as one possible way of reducing the emissions of ''greenhouse gases''. Much of the recent work on carbon taxation has concentrated on analysing the effects of introducing such a tax at a level which would meet certain emission targets at some fixed date. Less attention has been devoted to the time profile of this tax. Yet in securing international agreement on the introduction of a carbon tax it could matter greatly whether what is being proposed is a tax which is initially low but rising, or initially high but falling. We show that in a wide class of cases the optimal time path of the tax will be that it initially rises and then falls as the exhaustion constraint starts to bite. However there are few general conclusions, and much depends on more detailed modelling assumptions on which the scientific evidence gives no firm guidance. (author)

  9. The rise of colliding beams

    Richter, B.

    1992-06-01

    It is a particular pleasure for me to have this opportunity to review for you the rise of colliding beams as the standard technology for high-energy-physics accelerators. My own career in science has been intimately tied up in the transition from the old fixed-target technique to colliding-beam work. I have led a kind of double life both as a machine builder and as an experimenter, taking part in building and using the first of the colliding-beam machines, the Princeton-Stanford Electron-Electron Collider, and building the most recent advance in the technology, the Stanford Linear Collider. The beginning was in 1958, and in the 34 years since there has been a succession of both electron and proton colliders that have increased the available center-of-mass energy for hard collisions by more than a factor of 1000. For the historians here, I regret to say that very little of this story can be found in the conventional literature. Standard operating procedure for the accelerator physics community has been publication in conference proceedings, which can be obtained with some difficulty, but even more of the critical papers are in internal laboratory reports that were circulated informally and that may not even have been preserved. In this presentation I shall review what happened based on my personal experiences and what literature is available. I can speak from considerable experience on the electron colliders, for that is the topic in which I was most intimately involved. On proton colliders my perspective is more than of an observer than of a participant, but I have dug into the literature and have been close to many of the participants

  10. Radiation biology and radiation therapy

    Wideroee, R.

    1975-01-01

    Radiation biology and radiation therapy can be compared with investigations in different layers of earth. Radiation biology works upwards from the elementary foundations, therapy works downwards with roots to secure and improve the clinical 'surface work'. The Ellis formula (Strandquist), which is a collection of clinical experience, is suited to form connections with radiobiology in the middle layers, and cooperation can give impulses for research. The structure and conditions of tumours and the complicated problems met with are discussed, based on the Carmel symposium of 1969. The oxygen problem in anoxic tumours is not yet solved. Experimental investigations of the effect itself give partly contradictory results. From a clinical viewpoint reoxygenation is of the utmost significance for obtaining control over the primary tumour, and advanced irradiation programmes will here give better results than the traditional ones. New chemicals, e.g. R 0 -07-0582, appear to reduce the OER value to 1.5, thereby making neutron therapy superfluous. Finally a problem from fundamental research is dealt with, wherein two hypotheses explaining the β-effect are described. The repair hypothesis gives a simple explanation but leaves many questions unanswered. The other hypothesis explains the β-effect as two neighbouring single breaks of the DNA molecule. It still presents difficulties, and is scarcely the correct explanation. (JIW)

  11. Improvements in or relating to radiation detection arrangements

    Davis, G.P.

    1977-01-01

    A radiation detection arrangement is described that that comprises a number of scintillator devices, and a single multi-channel photomultiplier tube. Light from the scintillator devices is incident on the photocathode through an entrance window in the tube and multiplier entrance separating means are provided whereby light from each of the devices is made to be incident upon the channel entrances of photomultiplier tube. Various geometrical forms for the scintillator devices are described. This arrangement avoids the use of large number of small photomultiplier tubes, which is expensive and gives rise to difficulties in stacking the tubes in closely spaced side-by-side relationship. (U.K.)

  12. Statistics of EMIC Rising Tones Observed by the Van Allen Probes

    Sigsbee, K. M.; Kletzing, C.; Smith, C. W.; Santolik, O.

    2017-12-01

    We will present results from an ongoing statistical study of electromagnetic ion cyclotron (EMIC) wave rising tones observed by the Van Allen Probes. Using data from the Electric and Magnetic Field Instrument Suite and Integrated Science (EMFISIS) fluxgate magnetometer, we have identified orbits by both Van Allen Probes with EMIC wave events from the start of the mission in fall 2012 through fall 2016. Orbits with EMIC wave events were further examined for evidence of rising tones. Most EMIC wave rising tones were found during H+ band EMIC wave events. In Fourier time-frequency power spectrograms of the fluxgate magnetometer data, H+ band rising tones generally took the form of triggered emission type events, where the discrete rising tone structures rapidly rise in frequency out of the main band of observed H+ EMIC waves. A smaller percentage of EMIC wave rising tone events were found in the He+ band, where rising tones may appear as discrete structures with a positive slope embedded within the main band of observed He+ EMIC waves, similar in appearance to whistler-mode chorus elements. Understanding the occurrence rate and properties of rising tone EMIC waves will provide observational context for theoretical studies indicating that EMIC waves exhibiting non-linear behavior, such as rising tones, may be more effective at scattering radiation belt electrons than ordinary EMIC waves.

  13. Radiation protection, optimization and justification

    Cordoliani, Y.S.; Brisse, H.; Foucart, J.M.; Clement, J.P.; Ribeiro, A.; Gomes, H.; Marcus, C.; Rehel, J.L.; Talbot, A.; Aubert, B.; Scanff, P.; Roudier, C.; Donadieu, J.; Pirard, P.; Bar, O.; Maccia, C.; Benedittini, M.; Bouziane, T.; Brat, H.; Bricoult, M; Heuga, O.; Hauger, O.; Bonnefoy, O.; Diard, F.; Chateil, J.F.; Schramm, R.; Reisman, J.; Aubert, B.

    2005-01-01

    Nine articles in the field of radiation protection relative to the medical examinations concern the new legislation in radiation protection, the optimization of this one in order to reduce the radiation doses delivered to the patients, the side effects induced by irradiation and to give an evaluation of the medical exposure of french population to ionizing radiations. (N.C.)

  14. Relativistic rise measurement by cluster counting method in time expansion chamber

    Rehak, P.; Walenta, A.H.

    1979-10-01

    A new approach to the measurement of the ionization energy loss for the charged particle identification in the region of the relativistic rise was tested experimentally. The method consists of determining in a special drift chamber (TEC) the number of clusters of the primary ionization. The method gives almost the full relativistic rise and narrower landau distribution. The consequences for a practical detector are discussed

  15. Mathematical modeling of the Phoenix Rising pathway.

    Chad Liu

    2014-02-01

    Full Text Available Apoptosis is a tightly controlled process in mammalian cells. It is important for embryogenesis, tissue homoeostasis, and cancer treatment. Apoptosis not only induces cell death, but also leads to the release of signals that promote rapid proliferation of surrounding cells through the Phoenix Rising (PR pathway. To quantitatively understand the kinetics of interactions of different molecules in this pathway, we developed a mathematical model to simulate the effects of various changes in the PR pathway on the secretion of prostaglandin E2 (PGE2, a key factor for promoting cell proliferation. These changes include activation of caspase 3 (C3, caspase 7 (C7, and nuclear factor κB (NFκB. In addition, we simulated the effects of cyclooxygenase-2 (COX2 inhibition and C3 knockout on the level of secreted PGE2. The model predictions on PGE2 in MEF and 4T1 cells at 48 hours after 10-Gray radiation were quantitatively consistent with the experimental data in the literature. Compared to C7, the model predicted that C3 activation was more critical for PGE2 production. The model also predicted that PGE2 production could be significantly reduced when COX2 expression was blocked via either NFκB inactivation or treatment of cells with exogenous COX2 inhibitors, which led to a decrease in the rate of conversion from arachidonic acid to prostaglandin H2 in the PR pathway. In conclusion, the mathematical model developed in this study yielded new insights into the process of tissue regrowth stimulated by signals from apoptotic cells. In future studies, the model can be used for experimental data analysis and assisting development of novel strategies/drugs for improving cancer treatment or normal tissue regeneration.

  16. Radiation detector

    Gillies, W.

    1980-01-01

    The radiation detector for measuring e.g. a neutron flux consists of a central emitter, an insulating shell arranged around it, and a tube-shaped collector enclosing both. The emitter itself is composed of a great number of stranded, spiral wires of small diameter giving a defined flexibility to the detector. For emitter material Pt, Rh, V, Co, Ce, Os or Ta may be used. (DG) [de

  17. Radiation Protection: introduction

    Loos, M.

    2005-01-01

    The abstract gives an overview and introduction to the activities of SCK-CEN's Radiation Protection department. Main strategic developments and achievements in the field of life sciences, policy supports and medical applications are summarised

  18. Coupled radiative gasdynamic interaction and non-equilibrium dissociation for large-scale returned space vehicles

    Surzhikov, S.

    2012-01-01

    Graphical abstract: It has been shown that different coupled vibrational dissociation models, being applied for solving coupled radiative gasdynamic problems for large size space vehicles, exert noticeable effect on radiative heating of its surface at orbital entry on high altitudes (h ⩾ 70 km). This influence decreases with decreasing the space vehicles sizes. Figure shows translational (solid lines) and vibrational (dashed lines) temperatures in shock layer with (circle markers) and without (triangles markers) radiative-gasdynamic interaction for one trajectory point of entering space vehicle. Highlights: ► Nonequilibrium dissociation processes exert effect on radiation heating of space vehicles (SV). ► The radiation gas dynamic interaction enhances this influence. ► This influence increases with increasing the SV sizes. - Abstract: Radiative aerothermodynamics of large-scale space vehicles is considered for Earth orbital entry at zero angle of attack. Brief description of used radiative gasdynamic model of physically and chemically nonequilibrium, viscous, heat conductive and radiative gas of complex chemical composition is presented. Radiation gasdynamic (RadGD) interaction in high temperature shock layer is studied by means of numerical experiment. It is shown that radiation–gasdynamic coupling for orbital space vehicles of large size is important for high altitude part of entering trajectory. It is demonstrated that the use of different models of coupled vibrational dissociation (CVD) in conditions of RadGD interaction gives rise temperature variation in shock layer and, as a result, leads to significant variation of radiative heating of space vehicle.

  19. [Gift giving and the ethics of the caregiver].

    Grassin, Marc

    2014-12-01

    Modern societies establish relationships on a contract basis, but the caregiver relationship invariably involves the notion of a gift. Caring engages the giving / receiving / giving back circle of reciprocity. The caregiving relationship requires a gift ethic which gives meaning to the nurse/patient contract.

  20. Regional approaches in high-rise construction

    Iconopisceva, O. G.; Proskurin, G. A.

    2018-03-01

    The evolutionary process of high-rise construction is in the article focus. The aim of the study was to create a retrospective matrix reflecting the tasks of the study such as: structuring the most iconic high-rise objects within historic boundaries. The study is based on contemporary experience of high-rise construction in different countries. The main directions and regional specifics in the field of high-rise construction as well as factors influencing the further evolution process are analyzed. The main changes in architectural stylistics, form-building, constructive solutions that focus on the principles of energy efficiency and bio positivity of "sustainable buildings", as well as the search for a new typology are noted. The most universal constructive methods and solutions that turned out to be particularly popular are generalized. The new typology of high-rises and individual approach to urban context are noted. The results of the study as a graphical scheme made it possible to represent the whole high-rise evolution. The new spatial forms of high-rises lead them to new role within the urban environments. Futuristic hyperscalable concepts take the autonomous urban space functions itself and demonstrate us how high-rises can replace multifunctional urban fabric, developing it inside their shells.

  1. Molecular alterations in thyroid tumors induced after exposure to ionising radiation in infancy

    Bounacer, A.; Wicker, R.; Sarasin, A.; Suarez, H.G. [Institut Gustave Roussy, 94 - Villejuif (France); Schlumberger, M.; Caillou, B. [Institut de Recherches sur le Cancer, 94 - Villejuif (France)

    1997-03-01

    We investigated the presence of molecular lesions in the ras, gsp and ret genes, in epithelial thyroid tumors developed in patients who had received ionising radiation therapy in infancy for benign or malignant conditions. Our data showed: a similar frequency of ras and gsp activating mutations in radiation-associated and `spontaneous` tumors. However, while the mutations are only transversions in the radiation-associated tumors, they are transversions as well as transitions in the `spontaneous` ones and a mutation in codon 691 giving rise to a polymorphism in the ret gene, and frequently associated to a C-cell hyperplasia in radiation-associated tumors. The frequency of this mutation was significantly higher (60%) in these tumors, than in normal controls (21%) or `spontaneous` epithelial thyroid tumors (23%). (author)

  2. Molecular alterations in thyroid tumors induced after exposure to ionising radiation in infancy

    Bounacer, A.; Wicker, R.; Sarasin, A.; Suarez, H.G.; Schlumberger, M.; Caillou, B.

    1997-01-01

    We investigated the presence of molecular lesions in the ras, gsp and ret genes, in epithelial thyroid tumors developed in patients who had received ionising radiation therapy in infancy for benign or malignant conditions. Our data showed: a similar frequency of ras and gsp activating mutations in radiation-associated and 'spontaneous' tumors. However, while the mutations are only transversions in the radiation-associated tumors, they are transversions as well as transitions in the 'spontaneous' ones and a mutation in codon 691 giving rise to a polymorphism in the ret gene, and frequently associated to a C-cell hyperplasia in radiation-associated tumors. The frequency of this mutation was significantly higher (60%) in these tumors, than in normal controls (21%) or 'spontaneous' epithelial thyroid tumors (23%). (author)

  3. The implications of ICRP publication (60) 1990 for public exposure to natural radiation

    Laughlin, J.Mc.

    1992-01-01

    The implications of the new ICRP recommendations on the control of public exposure to natural radiation are described. As ICRP differentiates between Practices and Interventions the application of the basic recommendations in the case of natural radiation exposures will be discussed in this context. Particular emphasis will be placed on public exposure to indoor radon with some discussion on situations in which occupational and public exposure to this source occur together. This major source of public exposure i discussed in relation to both ICRP 60 and ICRP 39. Some of the difficulties that the new recommendations may give rise to in the management of natural radiation exposures are discussed. One of the major changes in the new recommendations concerns the area of risk. This will be briefly discussed as regards the ways in which the risk arising from public exposure to natural radiation may be assessed. (author)

  4. Mechanisms of interaction of radiation with matter

    Geacintov, N.E.; Pope, M.

    1991-01-01

    The combustion of fossil fuels gives rise to airborne particulates containing deposits of mutagenic and carcinogenic polynuclear aromatic (PNA) compounds. Part 1, results of detailed studies on the mechanisms of photoionization and photoemission of electrons from solid pyrene and nitropyrene derivatives, are described. A new time-resolved picosecond double-pulse laser technique is described for studying the mechanisms of photoemission in organic solids. Reactions of PNA radical cations at organic solid/aqueous electrolyte interfaces, are described in Part 2. The mechanisms of reactions of mutagenic metabolites of benzo[a]pyrene with nucleic acids is discussed in Part 3; it is shown that photoinduced electron transfer occurs from the nucleic acids to the PNA moieties giving rise to short-lived exciplexes with significant charge-transfer character. A new project on the effects of ionizing radiation (electrons, neutrons and gammas) on deoxyoligonucleotides of defined base sequence using high resolution gel electrophoresis is described in Part 4 of this report. 102 refs., 35 figs., 5 tabs

  5. Reconciling projections of the Antarctic contribution to sea level rise

    Edwards, Tamsin; Holden, Philip; Edwards, Neil; Wernecke, Andreas

    2017-04-01

    Two recent studies of the Antarctic contribution to sea level rise this century had best estimates that differed by an order of magnitude (around 10 cm and 1 m by 2100). The first, Ritz et al. (2015), used a model calibrated with satellite data, giving a 5% probability of exceeding 30cm by 2100 for sea level rise due to Antarctic instability. The second, DeConto and Pollard (2016), used a model evaluated with reconstructions of palaeo-sea level. They did not estimate probabilities, but using a simple assumption here about the distribution shape gives up to a 5% chance of Antarctic contribution exceeding 2.3 m this century with total sea level rise approaching 3 m. If robust, this would have very substantial implications for global adaptation to climate change. How are we to make sense of this apparent inconsistency? How much is down to the data - does the past tell us we will face widespread and rapid Antarctic ice losses in the future? How much is due to the mechanism of rapid ice loss ('cliff failure') proposed in the latter paper, or other parameterisation choices in these low resolution models (GRISLI and PISM, respectively)? How much is due to choices made in the ensemble design and calibration? How do these projections compare with high resolution, grounding line resolving models such as BISICLES? Could we reduce the huge uncertainties in the palaeo-study? Emulation provides a powerful tool for understanding these questions and reconciling the projections. By describing the three numerical ice sheet models with statistical models, we can re-analyse the ensembles and re-do the calibrations under a common statistical framework. This reduces uncertainty in the PISM study because it allows massive sampling of the parameter space, which reduces the sensitivity to reconstructed palaeo-sea level values and also narrows the probability intervals because the simple assumption about distribution shape above is no longer needed. We present reconciled probabilistic

  6. Who gives? Multilevel effects of gender and ethnicity on workplace charitable giving.

    Leslie, Lisa M; Snyder, Mark; Glomb, Theresa M

    2013-01-01

    Research on diversity in organizations has largely focused on the implications of gender and ethnic differences for performance, to the exclusion of other outcomes. We propose that gender and ethnic differences also have implications for workplace charitable giving, an important aspect of corporate social responsibility. Drawing from social role theory, we hypothesize and find that gender has consistent effects across levels of analysis; women donate more money to workplace charity than do men, and the percentage of women in a work unit is positively related to workplace charity, at least among men. Alternatively and consistent with social exchange theory, we hypothesize and find that ethnicity has opposing effects across levels of analysis; ethnic minorities donate less money to workplace charity than do Whites, but the percentage of minorities in a work unit is positively related to workplace charity, particularly among minorities. The findings provide a novel perspective on the consequences of gender and ethnic diversity in organizations and highlight synergies between organizational efforts to increase diversity and to build a reputation for corporate social responsibility. PsycINFO Database Record (c) 2013 APA, all rights reserved.

  7. Ethics of trial drug use: to give or not to give?

    Ebunoluwa, Oduwole O; Kareem, Fayemi A

    2016-01-01

    The 2014 outbreak of Ebola viral disease in some West African countries, which later spread to the USA and Spain, has continued to be a subject of global public health debate. While there is no approved vaccine or drug for Ebola cure yet, moral questions of bioethical significance are emerging even as vaccine studies are at different clinical trial phases. This paper, through a normative and critical approach, focuses on the question of whether it is ethical to give any experimental drugs to Ebola victims in West Africa or not. Given the global panic and deadly contagious nature of Ebola, this paper argues on three major compassionate grounds that it is ethical to use experimental drugs on the dying African victims of Ebola. Besides respecting patients and family consent in the intervention process, this paper argues that the use of Ebola trial drugs on West African population will be ethical if it promotes the common good, and does not violate the fundamental principles of transparency and integrity in human research ethics. Using Kantian ethical framework of universality as a basis for moral defense of allowing access to yet approved drugs. This paper provides argument to strengthen the compassionate ground provisional recommendation of the WHO's Strategic Advisory Group of Experts on Immunization (SAGE) on Ebola vaccines and vaccination.

  8. High-rise Buildings versus Outdoor Thermal Environment in Chongqing

    Jin-sha Wang

    2007-10-01

    Full Text Available This paper gives a brief description of the over quick urbanization sinceChongqing, one of the biggest cities in China, has been a municipality directly under theCentral Government in 1997, excessive development and exceeding increase of high-risebuildings because of its special geographical position which finally leads to the worseningof the urban outdoor thermal environment. Then, this paper makes a bright balance to thefield measurement and simulated results of the wind speed field, temperature field of onemultifunctional high-rise building in Chongqing university located in the city center, andthe contrasted results validate the correctness of CFD in the outdoor thermal environmentalsimulation, expose the disadvantages of high-rise buildings on the aspects of blocking thewind field, decreasing wind speed which results in accumulation of the air-conditioningheat revolving around and periscian region where sunshine can not rip into. Finally, inorder to improve the urban outdoor thermal environment near the high-rise buildingsespecially for the angle of natural ventilation, this paper simulates the wind environment indifferent architectural compositions and architectural layouts by CFD, and the simulatedresults show that freestyle and tower buildings which can guarantee the wind speed andtake the air-conditioning heat away are much suitable and reasonable for the specialChongqing geography. These conclusions can also be used as a reference in othermountain cities, especially for the one with a great number of populations.

  9. Radiative cooling of relativistic electron beams

    Huang, Zhirong [Stanford Univ., CA (United States)

    1998-05-01

    Modern high-energy particle accelerators and synchrotron light sources demand smaller and smaller beam emittances in order to achieve higher luminosity or better brightness. For light particles such as electrons and positrons, radiation damping is a natural and effective way to obtain low emittance beams. However, the quantum aspect of radiation introduces random noise into the damped beams, yielding equilibrium emittances which depend upon the design of a specific machine. In this dissertation, the author attempts to make a complete analysis of the process of radiation damping and quantum excitation in various accelerator systems, such as bending magnets, focusing channels and laser fields. Because radiation is formed over a finite time and emitted in quanta of discrete energies, he invokes the quantum mechanical approach whenever the quasiclassical picture of radiation is insufficient. He shows that radiation damping in a focusing system is fundamentally different from that in a bending system. Quantum excitation to the transverse dimensions is absent in a straight, continuous focusing channel, and is exponentially suppressed in a focusing-dominated ring. Thus, the transverse normalized emittances in such systems can in principle be damped to the Compton wavelength of the electron, limited only by the Heisenberg uncertainty principle. In addition, he investigates methods of rapid damping such as radiative laser cooling. He proposes a laser-electron storage ring (LESR) where the electron beam in a compact storage ring repetitively interacts with an intense laser pulse stored in an optical resonator. The laser-electron interaction gives rise to rapid cooling of electron beams and can be used to overcome the space charge effects encountered in a medium energy circular machine. Applications to the designs of low emittance damping rings and compact x-ray sources are also explored.

  10. Radiative cooling of relativistic electron beams

    Huang, Z.

    1998-05-01

    Modern high-energy particle accelerators and synchrotron light sources demand smaller and smaller beam emittances in order to achieve higher luminosity or better brightness. For light particles such as electrons and positrons, radiation damping is a natural and effective way to obtain low emittance beams. However, the quantum aspect of radiation introduces random noise into the damped beams, yielding equilibrium emittances which depend upon the design of a specific machine. In this dissertation, the author attempts to make a complete analysis of the process of radiation damping and quantum excitation in various accelerator systems, such as bending magnets, focusing channels and laser fields. Because radiation is formed over a finite time and emitted in quanta of discrete energies, he invokes the quantum mechanical approach whenever the quasiclassical picture of radiation is insufficient. He shows that radiation damping in a focusing system is fundamentally different from that in a bending system. Quantum excitation to the transverse dimensions is absent in a straight, continuous focusing channel, and is exponentially suppressed in a focusing-dominated ring. Thus, the transverse normalized emittances in such systems can in principle be damped to the Compton wavelength of the electron, limited only by the Heisenberg uncertainty principle. In addition, he investigates methods of rapid damping such as radiative laser cooling. He proposes a laser-electron storage ring (LESR) where the electron beam in a compact storage ring repetitively interacts with an intense laser pulse stored in an optical resonator. The laser-electron interaction gives rise to rapid cooling of electron beams and can be used to overcome the space charge effects encountered in a medium energy circular machine. Applications to the designs of low emittance damping rings and compact x-ray sources are also explored

  11. Rising tides, rising gates: The complex ecogeomorphic response of coastal wetlands to sea-level rise and human interventions

    Sandi, Steven G.; Rodríguez, José F.; Saintilan, Neil; Riccardi, Gerardo; Saco, Patricia M.

    2018-04-01

    Coastal wetlands are vulnerable to submergence due to sea-level rise, as shown by predictions of up to 80% of global wetland loss by the end of the century. Coastal wetlands with mixed mangrove-saltmarsh vegetation are particularly vulnerable because sea-level rise can promote mangrove encroachment on saltmarsh, reducing overall wetland biodiversity. Here we use an ecogeomorphic framework that incorporates hydrodynamic effects, mangrove-saltmarsh dynamics, and soil accretion processes to assess the effects of control structures on wetland evolution. Migration and accretion patterns of mangrove and saltmarsh are heavily dependent on topography and control structures. We find that current management practices that incorporate a fixed gate for the control of mangrove encroachment are useful initially, but soon become ineffective due to sea-level rise. Raising the gate, to counteract the effects of sea level rise and promote suitable hydrodynamic conditions, excludes mangrove and maintains saltmarsh over the entire simulation period of 100 years

  12. The physics of radiation protection

    Doerschel, B.; Schuricht, V.; Steuer, J.

    1996-01-01

    The book is aimed at both practising specialists and scientists wishing to learn about the fundamental science of radiation protection. The first part of the book, 'Physical Fundamentals of Radiation Protection', presents a concise description of radiation sources and radiation fields, interaction of radiation with matter, radiation effects and radiation damage, basic concept of radiation protection, radiation exposure of man, radiation protection measuring techniques and physical fundamentals for limiting radiation exposure. The second part, 'Calculational Exercises for Radiation Protection' is intended to supplement the first part by carrying out relevant calculations, amending and adding special aspects and to give guidance in solving practical problems. The book is written for scientists as well as for students and staff working in nuclear facilities, hospitals and institutions responsible for radiation and environmental protection. (UK)

  13. Historical aspects of radiation accidents

    Mettler, F.A. Jr.; Ricks, R.C.

    1990-01-01

    Radiation accidents are extremely rare events; however, the last two years have witnessed the largest radiation accidents in both the eastern and western hemispheres. It is the purpose of this chapter to review how radiation accidents are categorized, examine the temporal changes in frequency and severity, give illustrative examples of several types of radiation accidents, and finally, to describe the various registries for radiation accidents

  14. Practical radiation monitoring

    Keightley, Lynsey; Burgess, Peter; Delahunty, Denise; Richards, Tony; Simpson, John; Woods, Mike

    2002-01-01

    This Good Practice Guide has been written by a working party of experts from the UK Ionising Radiation Metrology Forum. It describes procedures and methods for assessing radiation levels, outlines the thought processes needed to carry out the measurements and gives practical advice. The methods described are general and based on currently accepted good practice

  15. Radiation Therapy (For Parents)

    ... dose given. Radiation on the brain may affect learning and memory. Your doctor can offer advice and may prescribe medications to make your child more comfortable during radiation treatment. Make sure you avoid giving your child any medicines, including herbal medicines or over-the-counter (OTC) ...

  16. Prostaglandis and radiation

    Romantsev, E.F.; Blokhina, V.D.; Zhulanova, Z.I.; Koshcheenko, I.N.; Nikol'skij, A.V.; Filippovich, I.V.

    1984-01-01

    It was established that some biochemical distortions in the brain of animals, subjected to superlethal doses of ionizing radiation don't develope; the starting mechanisms of a radiation damage can be fundamentally another, as compared to the medullar and intestinal forms of radiation sickness. It enables to assume that observed changes in activity of prostaglandin-synthetase system during irradiation by 250 Gr dose are based on earlier formed changes in membrane permeability and distortion of receptor cell activity. Investigations of the effect of radiation damage modificators give additional information when studying the primary biochemical processes, initiating radiation sickness

  17. Radiation-Induced Bystander Response: Mechanism and Clinical Implications

    Suzuki, Keiji; Yamashita, Shunichi

    2014-01-01

    Significance: Absorption of energy from ionizing radiation (IR) to the genetic material in the cell gives rise to damage to DNA in a dose-dependent manner. There are two types of DNA damage; by a high dose (causing acute or deterministic effects) and by a low dose (related to chronic or stochastic effects), both of which induce different health effects. Among radiation effects, acute cutaneous radiation syndrome results from cell killing as a consequence of high-dose exposure. Recent advances: Recent advances in radiation biology and oncology have demonstrated that bystander effects, which are emerged in cells that have never been exposed, but neighboring irradiated cells, are also involved in radiation effects. Bystander effects are now recognized as an indispensable component of tissue response related to deleterious effects of IR. Critical issues: Evidence has indicated that nonapoptotic premature senescence is commonly observed in various tissues and organs. Senesced cells were found to secrete various proteins, including cytokines, chemokines, and growth factors, most of which are equivalent to those identified as bystander factors. Secreted factors could trigger cell proliferation, angiogenesis, cell migration, inflammatory response, etc., which provide a tissue microenvironment assisting tissue repair and remodeling. Future directions: Understandings of the mechanisms and physiological relevance of radiation-induced bystander effects are quite essential for the beneficial control of wound healing and care. Further studies should extend our knowledge of the mechanisms of bystander effects and mode of cell death in response to IR. PMID:24761341

  18. Climate Adaptation and Sea Level Rise

    EPA supports the development and maintenance of water utility infrastructure across the country. Included in this effort is helping the nation’s water utilities anticipate, plan for, and adapt to risks from flooding, sea level rise, and storm surge.

  19. Inequality and redistribution behavior in a give-or-take game

    Bechtel, Michael M.; Scheve, Kenneth F.

    2018-01-01

    Political polarization and extremism are widely thought to be driven by the surge in economic inequality in many countries around the world. Understanding why inequality persists depends on knowing the causal effect of inequality on individual behavior. We study how inequality affects redistribution behavior in a randomized “give-or-take” experiment that created equality, advantageous inequality, or disadvantageous inequality between two individuals before offering one of them the opportunity to either take from or give to the other. We estimate the causal effect of inequality in representative samples of German and American citizens (n = 4,966) and establish two main findings. First, individuals imperfectly equalize payoffs: On average, respondents transfer 12% of the available endowments to realize more equal wealth distributions. This means that respondents tolerate a considerable degree of inequality even in a setting in which there are no costs to redistribution. Second, redistribution behavior in response to disadvantageous and advantageous inequality is largely asymmetric: Individuals who take from those who are richer do not also tend to give to those who are poorer, and individuals who give to those who are poorer do not tend to take from those who are richer. These behavioral redistribution types correlate in meaningful ways with support for heavy taxes on the rich and the provision of welfare benefits for the poor. Consequently, it seems difficult to construct a majority coalition willing to back the type of government interventions needed to counter rising inequality. PMID:29555734

  20. Interconnect rise time in superconducting integrating circuits

    Preis, D.; Shlager, K.

    1988-01-01

    The influence of resistive losses on the voltage rise time of an integrated-circuit interconnection is reported. A distribution-circuit model is used to present the interconnect. Numerous parametric curves are presented based on numerical evaluation of the exact analytical expression for the model's transient response. For the superconducting case in which the series resistance of the interconnect approaches zero, the step-response rise time is longer but signal strength increases significantly

  1. Radiation protection and regulatory aspects in the use of radiation sources

    Sen, Amit; Dash Sharma, P.K.; Sonawane, A.U.

    2012-01-01

    The uses of ionising radiation sources (i.e. radioisotopes and radiation generating equipment such as accelerators and X-ray machines) for multifarious applications in industry, medicine, agriculture, research and teaching have been significantly increasing all over the world. In India, the application of radiation sources in various fields has registered phenomenal growth during the last decade. The use of radiation sources mainly include radiation processing for food preservation and sterilization of healthcare products, radiotherapy for treatment of cancer, nuclear medicine for diagnosis and therapy, gamma chambers for several R and D studies, blood irradiators, industrial radiography for non destructive examinations of steel structures, industrial ionising radiation gauging devices for monitoring/measurement of on-line quality control parameters (e.g. thickness, level, density, moisture, elemental analysis), consumer products such as gaseous tritium light sources (GTLS), gaseous tritium light devices (GTLD), ionisation chamber smoke detectors (ICSD), fluorescent light starters, antistatic devices and incandescent gas mantles containing thorium etc. All these beneficial applications involve use of both sealed and unsealed radioactive sources and amount of radioactivity varies from few kBq (μCi) to hundreds of TBq (thousands of curies). Radiation sources emit ionising radiations and if not handled properly and safely, may give rise to potential exposures leading to an unacceptable hazard. Therefore, it is necessary to ensure a high standard of safety and reliability in handling of radiation equipment and sources through their careful design by ensuring adequate built-in-safety as per applicable national/international standard, safe operation and periodic maintenance procedures, safe transport from one place to another, secured storage when not in use, physical security to radiation sources, effective emergency response plans and preparedness, including safe

  2. Modeling of terahertz radiation emission from a free-electron laser

    Sharma, Suresh C.; Panwar, Jyotsna; Sharma, Rinku [Department of Applied Physics, Delhi Technological University, Delhi (India)

    2017-05-15

    In this article, we report the generation of terahertz (THz) radiation using the interaction of a laser-modulated relativistic electron beam (REB) with a surface plasma wave. Two laser beams propagating through the modulator interact with the REB, leading to velocity modulation of the beam. This results in pre-bunching of the REB. The pre-bunched beam travels through the drift space, where the velocity modulation translates into density modulation. The density-modulated beam, on interacting with the surface plasma pump wave, acquires an oscillatory velocity that couples with the modulated beam density to give rise to a nonlinear current density which acts as an antenna to give THz radiation. By optimizing the parameters of the beam and the wiggler, we obtain power of the order of 10{sup -4} using the current scheme. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  3. Man and radiation effects

    Rausch, L.

    1982-01-01

    The book describes the effects of ionizing radiation on man in a simple, popular, detailed and generally valid manner and gives a comprehensive picture of the concepts, elements, principles of function, and perspectives of medical radiobiology. Radiobiology in general is explained, and its application in research on the causes of radiolesions and radiation diseases as well as a radiotherapy and radiation protection is discussed in popular form. (orig./MG) [de

  4. Radiation-induced creep and swelling

    Heald, P.T.

    1977-01-01

    The physical basis for radiation induced creep and swelling is reviewed. The interactions between the point defects and dislocations are recalled since these interactions are ultimately responsible for the observable deformation phenomena. Both the size misfit interaction and the induced inhomogeneity interaction are considered since the former gives rise to irradiation swelling while the latter, which depends on both internal and external stresses, results in irradiation creep. The defect kinetics leading to the deformation processes are discussed in terms of chemical rate theory. The rate equations for the spatially averaged interstitial and vacancy concentrations are expressed in terms of the microstructural sink strengths and the solution of these equations leads to general expressions for the deformation rates

  5. HiRISE: The People's Camera

    McEwen, A. S.; Eliason, E.; Gulick, V. C.; Spinoza, Y.; Beyer, R. A.; HiRISE Team

    2010-12-01

    The High Resolution Imaging Science Experiment (HiRISE) camera, orbiting Mars since 2006 on the Mars Reconnaissance Orbiter (MRO), has returned more than 17,000 large images with scales as small as 25 cm/pixel. From it’s beginning, the HiRISE team has followed “The People’s Camera” concept, with rapid release of useful images, explanations, and tools, and facilitating public image suggestions. The camera includes 14 CCDs, each read out into 2 data channels, so compressed images are returned from MRO as 28 long (up to 120,000 line) images that are 1024 pixels wide (or binned 2x2 to 512 pixels, etc.). This raw data is very difficult to use, especially for the public. At the HiRISE operations center the raw data are calibrated and processed into a series of B&W and color products, including browse images and JPEG2000-compressed images and tools to make it easy for everyone to explore these enormous images (see http://hirise.lpl.arizona.edu/). Automated pipelines do all of this processing, so we can keep up with the high data rate; images go directly to the format of the Planetary Data System (PDS). After students visually check each image product for errors, they are fully released just 1 month after receipt; captioned images (written by science team members) may be released sooner. These processed HiRISE images have been incorporated into tools such as Google Mars and World Wide Telescope for even greater accessibility. 51 Digital Terrain Models derived from HiRISE stereo pairs have been released, resulting in some spectacular flyover movies produced by members of the public and viewed up to 50,000 times according to YouTube. Public targeting began in 2007 via NASA Quest (http://marsoweb.nas.nasa.gov/HiRISE/quest/) and more than 200 images have been acquired, mostly by students and educators. At the beginning of 2010 we released HiWish (http://www.uahirise.org/hiwish/), opening HiRISE targeting to anyone in the world with Internet access, and already more

  6. 14 CFR 221.140 - Method of giving concurrence.

    2010-01-01

    ...) Conflicting authority to be avoided. Care should be taken to avoid giving authority to two or more carriers... Aviation shall be used by a carrier to give authority to another carrier to issue and file with the... used as authority to file joint fares or charges in which the carrier to whom the concurrence is given...

  7. Principle of Care and Giving to Help People in Need.

    Bekkers, René; Ottoni-Wilhelm, Mark

    2016-01-01

    Theories of moral development posit that an internalized moral value that one should help those in need-the principle of care-evokes helping behaviour in situations where empathic concern does not. Examples of such situations are helping behaviours that involve cognitive deliberation and planning, that benefit others who are known only in the abstract, and who are out-group members. Charitable giving to help people in need is an important helping behaviour that has these characteristics. Therefore we hypothesized that the principle of care would be positively associated with charitable giving to help people in need, and that the principle of care would mediate the empathic concern-giving relationship. The two hypotheses were tested across four studies. The studies used four different samples, including three nationally representative samples from the American and Dutch populations, and included both self-reports of giving (Studies 1-3), giving observed in a survey experiment (Study 3), and giving observed in a laboratory experiment (Study 4). The evidence from these studies indicated that a moral principle to care for others was associated with charitable giving to help people in need and mediated the empathic concern-giving relationship. © 2016 The Authors. European Journal of Personality published by John Wiley & Sons Ltd on behalf of European Association of Personality Psychology.

  8. Characterization of a multidrug resistant Salmonella enterica give ...

    Salmonella enterica Give is one of the serotypes that have been incriminated in Salmonella infections; sometimes associated with hospitalization and mortalities in humans and animals in some parts of the world. In this work, we characterized one Salmonella Give isolated from cloaca swab of an Agama agama lizard ...

  9. The notion of gift-giving and organ donation.

    Gerrand, Nicole

    1994-04-01

    The analogy between gift-giving and organ donation was first suggested at the beginning of the transplantation era, when policy makers and legislators were promoting voluntary organ donation as the preferred procurement procedure. It was believed that the practice of gift-giving had some features which were also thought to be necessary to ensure that an organ procurement procedure would be morally acceptable, namely voluntarism and altruism. Twenty-five years later, the analogy between gift-giving and organ donation is still being made in the literature and used in organ donation awareness campaigns. In this paper I want to challenge this analogy. By examining a range of circumstances in which gift-giving occurs, I argue that the significant differences between the various types of gift-giving and organ donation makes any analogy between the two very general and superficial, and I suggest that a more appropriate analogy can be found elsewhere.

  10. OPINION GIVING SERVICES AS A SOURCE OF CONSUMER INFORMATION

    Joanna Wyrwisz

    2015-09-01

    Full Text Available The goal of the article is to determine the place and role of opinion giving services in consumer behaviours. The discussion is conducted around the thesis saying that in the information society, opinion giving services constitute an important source of information for consumers in the process of selecting and purchasing both products and services. In the article the research approach based on the theoretical and empirical examinations was presented. The discussion starts with presenting a defi nition and types of opinion giving services which constitute the base for the characteristics of activities and usefulness of web portals collecting consumers opinions. The use of opinion giving services provided in the purchase process was evaluated. An essential interest in other consumers opinions, placed in Internet, was observed together with perceiving them as credible. Positive assessment of the functionality of opinion giving services was noticed.

  11. Socioecological Aspects of High-rise Construction

    Eichner, Michael; Ivanova, Zinaida

    2018-03-01

    In this article, the authors consider the socioecological problems that arise in the construction and operation of high-rise buildings. They study different points of view on high-rise construction and note that the approaches to this problem are very different. They also analyse projects of modern architects and which attempts are made to overcome negative impacts on nature and mankind. The article contains materials of sociological research, confirming the ambivalent attitude of urban population to high-rise buildings. In addition, one of the author's sociological survey reveals the level of environmental preparedness of the university students, studying in the field of "Construction of unique buildings and structures", raising the question of how future specialists are ready to take into account socioecological problems. Conclusion of the authors: the construction of high-rise buildings is associated with huge social and environmental risks, negative impact on the biosphere and human health. This requires deepened skills about sustainable design methods and environmental friendly construction technologies of future specialists. Professor M. Eichner presents in the article his case study project results on implementation of holistic eco-sustainable construction principles for mixed-use high-rise building in the metropolis of Cairo.

  12. Strategic advantages of high-rise construction

    Yaskova Natalya

    2018-01-01

    Full Text Available Traditional methods to assess the competitiveness of different types of real estate in the context of huge changes of new technological way of life don’t provide building solutions that would be correct from a strategic perspective. There are many challenges due to changes in the consumers’ behavior in the housing area. A multiplicity of life models, a variety of opportunities and priorities, traditions and new trends in construction should be assessed in terms of prospective benefits in the environment of the emerging new world order. At the same time, the mane discourse of high-rise construction mainly relates to its design features, technical innovations, and architectural accents. We need to clarify the criteria for economic evaluation of high-rise construction in order to provide decisions with clear and quantifiable contexts. The suggested approach to assessing the strategic advantage of high-rise construction and the prospects for capitalization of high-rise buildings poses new challenges for the economy to identify adequate quantitative assessment methods of the high-rise buildings economic efficiency, taking into account all stages of their life cycle.

  13. Socioecological Aspects of High-rise Construction

    Eichner Michael

    2018-01-01

    Full Text Available In this article, the authors consider the socioecological problems that arise in the construction and operation of high-rise buildings. They study different points of view on high-rise construction and note that the approaches to this problem are very different. They also analyse projects of modern architects and which attempts are made to overcome negative impacts on nature and mankind. The article contains materials of sociological research, confirming the ambivalent attitude of urban population to high-rise buildings. In addition, one of the author’s sociological survey reveals the level of environmental preparedness of the university students, studying in the field of "Construction of unique buildings and structures", raising the question of how future specialists are ready to take into account socioecological problems. Conclusion of the authors: the construction of high-rise buildings is associated with huge social and environmental risks, negative impact on the biosphere and human health. This requires deepened skills about sustainable design methods and environmental friendly construction technologies of future specialists. Professor M. Eichner presents in the article his case study project results on implementation of holistic eco-sustainable construction principles for mixed-use high-rise building in the metropolis of Cairo.

  14. Strategic advantages of high-rise construction

    Yaskova, Natalya

    2018-03-01

    Traditional methods to assess the competitiveness of different types of real estate in the context of huge changes of new technological way of life don't provide building solutions that would be correct from a strategic perspective. There are many challenges due to changes in the consumers' behavior in the housing area. A multiplicity of life models, a variety of opportunities and priorities, traditions and new trends in construction should be assessed in terms of prospective benefits in the environment of the emerging new world order. At the same time, the mane discourse of high-rise construction mainly relates to its design features, technical innovations, and architectural accents. We need to clarify the criteria for economic evaluation of high-rise construction in order to provide decisions with clear and quantifiable contexts. The suggested approach to assessing the strategic advantage of high-rise construction and the prospects for capitalization of high-rise buildings poses new challenges for the economy to identify adequate quantitative assessment methods of the high-rise buildings economic efficiency, taking into account all stages of their life cycle.

  15. Thermal Radiation for Structural Fire Safety Design

    Hertz, Kristian Dahl

    2006-01-01

    The lecture notes give a short introduction of the theory of thermal radiation. The most elementary concepts and methods are presented in order to give a fundamental knowledge for calculation of the load bearing capacities of fire exposed building constructions....

  16. Detection limits of absorbed dose of ionizing radiation in molluscan shells as determined by e.p.r. spectroscopy

    Stachowicz, W.; Michalik, J.; Burlinska, G.; Sadlo, J.; Dziedzic-Goclawska, A.; Ostrowski, K.

    1995-01-01

    The exposure of waters to ionizing radiation from radionuclides imprisoned in dumped nuclear waste containers, freed in nuclear submarine accidents or released in underwater magma eruptions are difficult to be evaluated by conventional radiometric methods. Ionizing radiation evokes stable paramagnetic centers in crystalline lattice of mineral components in bone skeletons of mammals and fishes as well as in exoskeletons of mollusca. They give rise in e.p.r. to specific, extremely stable signals which are proposed to be applied as indicators of radiation exposure levels. In the present study the e.p.r. detection limits of the dose of ionizing radiation absorbed in shells of fresh water and marine mollusca (selected species) have been estimated. It has been found that with fresh water mollusca the dose of 1-2 Gy can be detected, while the sea water mollusca by one order of magnitude lower, i.e. about 0.1 Gy. (author)

  17. Density ratios in compressions driven by radiation pressure

    Lee, S.

    1988-01-01

    It has been suggested that in the cannonball scheme of laser compression the pellet may be considered to be compressed by the 'brute force' of the radiation pressure. For such a radiation-driven compression, an energy balance method is applied to give an equation fixing the radius compression ratio K which is a key parameter for such intense compressions. A shock model is used to yield specific results. For a square-pulse driving power compressing a spherical pellet with a specific heat ratio of 5/3, a density compression ratio Γ of 27 is computed. Double (stepped) pulsing with linearly rising power enhances Γ to 1750. The value of Γ is not dependent on the absolute magnitude of the piston power, as long as this is large enough. Further enhancement of compression by multiple (stepped) pulsing becomes obvious. The enhanced compression increases the energy gain factor G for a 100 μm DT pellet driven by radiation power of 10 16 W from 6 for a square pulse power with 0.5 MJ absorbed energy to 90 for a double (stepped) linearly rising pulse with absorbed energy of 0.4 MJ assuming perfect coupling efficiency. (author)

  18. [The rise and fall of an physician entrepreneur].

    Dörnyei, Sándor

    2002-01-01

    In 1927 one of the most up-to-date and most beautiful sanatoriums of Central Europe was built on the hills of Buda by László Jakab MD (1875-1940), who at that time had already run - since 1909 - a successful health-resort, the rather popular and successful "Liget-Sanatorium": following a period of expansion and flourishing, his enterprise bankrupted. (The building itself was renewed after World War II - it served first as a hospital for tuberculosis patients and later as a university clinic for internal medicine.) This article tells the story of an entrepreneur physician, including his former and more successful attempts to run a health-care business, and gives detailed account of the rise and fall of private health-resort in prewar Hungary.

  19. Beam Induced Pressure Rise at RHIC

    Zhang, S Y; Bai, Mei; Blaskiewicz, Michael; Cameron, Peter; Drees, Angelika; Fischer, Wolfram; Gullotta, Justin; He, Ping; Hseuh Hsiao Chaun; Huang, Haixin; Iriso, Ubaldo; Lee, Roger C; Litvinenko, Vladimir N; MacKay, William W; Nicoletti, Tony; Oerter, Brian; Peggs, Steve; Pilat, Fulvia Caterina; Ptitsyn, Vadim; Roser, Thomas; Satogata, Todd; Smart, Loralie; Snydstrup, Louis; Thieberger, Peter; Trbojevic, Dejan; Wang, Lanfa; Wei, Jie; Zeno, Keith

    2005-01-01

    Beam induced pressure rise in RHIC warm sections is currently one of the machine intensity and luminosity limits. This pressure rise is mainly due to electron cloud effects. The RHIC warm section electron cloud is associated with longer bunch spacings compared with other machines, and is distributed non-uniformly around the ring. In addition to the countermeasures for normal electron cloud, such as the NEG coated pipe, solenoids, beam scrubbing, bunch gaps, and larger bunch spacing, other studies and beam tests toward the understanding and counteracting RHIC warm electron cloud are of interest. These include the ion desorption studies and the test of anti-grazing ridges. For high bunch intensities and the shortest bunch spacings, pressure rises at certain locations in the cryogenic region have been observed during the past two runs. Beam studies are planned for the current 2005 run and the results will be reported.

  20. Rising Long-term Interest Rates

    Hallett, Andrew Hughes

    Rather than chronicle recent developments in European long-term interest rates as such, this paper assesses the impact of increases in those interest rates on economic performance and inflation. That puts us in a position to evaluate the economic pressures for further rises in those rates......, the first question posed in this assignment, and the scope for overshooting (the second question), and then make some illustrative predictions of future interest rates in the euro area. We find a wide range of effects from rising interest rates, mostly small and mostly negative, focused on investment...... till the emerging European recovery is on a firmer basis and capable of overcoming increases in the cost of borrowing and shrinking fiscal space. There is also an implication that worries about rising/overshooting interest rates often reflect the fact that inflation risks are unequally distributed...

  1. Highly sensitive detection of ionizing radiations by a photoluminescent uranyl organic framework

    Xie, Jian; Wang, Yaxing; Liu, Wei; Yin, Xuemiao; Chen, Lanhua; Diwu, Juan; Chai, Zhifang; Wang, Shuao [School for Radiological and interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou (China); Zou, Youming [High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui (China); Albrecht-Schmitt, Thomas E. [Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL (United States); Liu, Guokui [Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, IL (United States)

    2017-06-19

    Precise detection of low-dose X- and γ-radiations remains a challenge and is particularly important for studying biological effects under low-dose ionizing radiation, safety control in medical radiation treatment, survey of environmental radiation background, and monitoring cosmic radiations. We report here a photoluminescent uranium organic framework, whose photoluminescence intensity can be accurately correlated with the exposure dose of X- or γ-radiations. This allows for precise and instant detection of ionizing radiations down to the level of 10{sup -4} Gy, representing a significant improvement on the detection limit of approximately two orders of magnitude, compared to other chemical dosimeters reported up to now. The electron paramagnetic resonance analysis suggests that with the exposure to radiations, the carbonyl double bonds break affording oxo-radicals that can be stabilized within the conjugated uranium oxalate-carboxylate sheet. This gives rise to a substantially enhanced equatorial bonding of the uranyl(VI) ions as elucidated by the single-crystal structure of the γ-ray irradiated material, and subsequently leads to a very effective photoluminescence quenching through phonon-assisted relaxation. The quenched sample can be easily recovered by heating, enabling recycled detection for multiple runs. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

  2. The 1988 coal outlook: steadily rising consumption

    Soras, C.G.; Stodden, J.R.

    1987-12-01

    Total coal use - domestic and foreign - will reach 910 million tons in 1988, an expansion of 1.3% from an estimated 898 million tons in 1987. The overall rise in consumption will add to inventory needs. Moreover, lower interest rates cut effective carrying costs and further encourage the holding of coal stocks by users. The results will be a gain in inventories of 3.5 tons by the end of 1988. As a result of all these factors, coal production is anticipated to rise by 11.6 million tons, or 1.2%, which projects firm markets in a time of relatively soft economic conditions in the USA. 2 tabs.

  3. Regulatory Control of Radiation Sources. Safety Guide

    2009-01-01

    This Safety Guide is intended to assist States in implementing the requirements established in Safety Standards Series No. GS-R-1, Legal and Governmental Infrastructure for Nuclear, Radiation, Radioactive Waste and Transport Safety, for a national regulatory infrastructure to regulate any practice involving radiation sources in medicine, industry, research, agriculture and education. The Safety Guide provides advice on the legislative basis for establishing regulatory bodies, including the effective independence of the regulatory body. It also provides guidance on implementing the functions and activities of regulatory bodies: the development of regulations and guides on radiation safety; implementation of a system for notification and authorization; carrying out regulatory inspections; taking necessary enforcement actions; and investigating accidents and circumstances potentially giving rise to accidents. The various aspects relating to the regulatory control of consumer products are explained, including justification, optimization of exposure, safety assessment and authorization. Guidance is also provided on the organization and staffing of regulatory bodies. Contents: 1. Introduction; 2. Legal framework for a regulatory infrastructure; 3. Principal functions and activities of the regulatory body; 4. Regulatory control of the supply of consumer products; 5. Functions of the regulatory body shared with other governmental agencies; 6. Organization and staffing of the regulatory body; 7. Documentation of the functions and activities of the regulatory body; 8. Support services; 9. Quality management for the regulatory system.

  4. Spherically symmetric radiation in gravitational collapse

    Bridy, D.J.

    1983-01-01

    This paper investigates a previously neglected mode by which a star may lose energy in the late stages of gravitational collapse to the black hole state. A model consisting of a Schwarzschild exterior matched to a Friedman interior of collapsing pressureless dust is studied. The matter of the collapsing star is taken as the source of a massive vector boson field and a detailed boundary value problem is carried out. Vector mesons are strongly coupled to all nucleons and will be radiated by ordinary matter during the collapse. The time dependent coupling between interior and exterior modes matched across the moving boundary of the collapsing star and the presence of the gravitational fields and their gradients in the field equations may give rise to a parametric amplification mechanism and permit the gravitational field to pump energy into the boson field, greatly enhancing the amount of boson radiation. The significance of a radiative mechanism driven by collapse is that it can react back upon the collapsing source and deprive it of some of the very mass that drives the collapse via its self gravitation. If the mass loss is great enough, this may provide a mechanism to slow or even halt gravitational collapse in some cases

  5. Numerical Investigation of Microgravity Tank Pressure Rise Due to Boiling

    Hylton, Sonya; Ibrahim, Mounir; Kartuzova, Olga; Kassemi, Mohammad

    2015-01-01

    The ability to control self-pressurization in cryogenic storage tanks is essential for NASAs long-term space exploration missions. Predictions of the tank pressure rise in Space are needed in order to inform the microgravity design and optimization process. Due to the fact that natural convection is very weak in microgravity, heat leaks into the tank can create superheated regions in the liquid. The superheated regions can instigate microgravity boiling, giving rise to pressure spikes during self-pressurization. In this work, a CFD model is developed to predict the magnitude and duration of the microgravity pressure spikes. The model uses the Schrage equation to calculate the mass transfer, with a different accommodation coefficient for evaporation at the interface, condensation at the interface, and boiling in the bulk liquid. The implicit VOF model was used to account for the moving interface, with bounded second order time discretization. Validation of the models predictions was carried out using microgravity data from the Tank Pressure Control Experiment, which flew aboard the Space Shuttle Mission STS-52. Although this experiment was meant to study pressurization and pressure control, it underwent boiling during several tests. The pressure rise predicted by the CFD model compared well with the experimental data. The ZBOT microgravity experiment is scheduled to fly on February 2016 aboard the ISS. The CFD model was also used to perform simulations for setting parametric limits for the Zero-Boil-Off Tank (ZBOT) Experiments Test Matrix in an attempt to avoid boiling in the majority of the test runs that are aimed to study pressure increase rates during self-pressurization. *Supported in part by NASA ISS Physical Sciences Research Program, NASA HQ, USA

  6. Salt Damage and Rising Damp Treatment in Building Structures

    J. M. P. Q. Delgado

    2016-01-01

    Full Text Available Salt damage can affect the service life of numerous building structures, both historical and contemporary, in a significant way. In this review, various damage mechanisms to porous building materials induced by salt action are analyzed. The importance of pretreatment investigations is discussed as well; in combination with the knowledge of salt and moisture transport mechanisms they can give useful indications regarding treatment options. The methods of salt damage treatment are assessed then, including both passive techniques based on environmental control, reduction of water transport, or conversion to less soluble salts and active procedures resulting in the removal of salts from deterioration zones. It is concluded that cellulose can still be considered as the favorite material presently used in desalination poultices but hydrophilic mineral wool can serve as its prospective alternative in future applications. Another important cause of building pathologies is the rising damp and, in this phenomenon, it is particularly severe considering the presence of salts in water. The treatment of rising damp in historic building walls is a very complex procedure and at Laboratory of Building Physics (LFC-FEUP a wall base hygroregulated ventilation system was developed and patented.

  7. The accompanying adult: authority to give consent in the UK.

    Lal, Seema Madhur Lata; Parekh, Susan; Mason, Carol; Roberts, Graham

    2007-05-01

    Children may be accompanied by various people when attending for dental treatment. Before treatment is started, there is a legal requirement that the operator obtain informed consent for the proposed procedure. In the case of minors, the person authorized to give consent (parental responsibility) is usually a parent. To ascertain if accompanying persons of children attending the Department of Paediatric Dentistry at the Eastman Dental Hospital, London were empowered to give consent for the child's dental treatment. A total of 250 accompanying persons of children attending were selected, over a 6-month period. A questionnaire was used to establish whether the accompanying person(s) were authorized to give consent. The study showed that 12% of accompanying persons had no legal authority to give consent for the child's dental treatment. Clinicians need to be aware of the status of persons accompanying children to ensure valid consent is obtained.

  8. When may doctors give nurses telephonic treatment instructions?

    When is it legal for doctors to give nurses telephonic treatment instructions? ... telemedicine? Telemedicine is defined as 'the practice of medicine, from a distance, ... [6] Therefore, if in such circumstances the doctors cannot reach the patients in ...

  9. Markel senior vice president to give Wachovia Lecture

    Ho, Sookhan

    2008-01-01

    Markel Corporation's senior vice president and chief financial officer Richard R. Whitt will give a talk on Thursday, Nov. 13, as the Wachovia Distinguished Speaker in the Pamplin College of Business.

  10. developing skills of giving and receiving feedbacks between

    User

    could be by developing the skill of giving and receiving feedbacks among the individuals involved in the ... education rather than damaging their self esteem against to improve the teaching – process (David ..... A better skill of communication.

  11. Reciprocity revisited: Give and take in Dutch and immigrant families

    Komter, A.; Schans, J.M.D.

    2008-01-01

    Classical theory suggests that "generalized reciprocity," giving without clear expectations of returns, is characteristic for exchange within the family. Modern theory assumes differences between Western, "individualistic" cultures, and non-Western, more "collectivistic" cultures, presumably leading

  12. Benefits of Giving (A Book Review Using Islamic Perspective

    M. Hamdar Arraiyyah

    2016-01-01

    Full Text Available This writing is a book review. It discusses a book entitled Give and Take. The book introduces a new approach to success. It makes three categories of people in doing interaction or communication. They are takers, matchers, and givers. The writer of the book, Adam Grant, explains the principles and characteristics of each category. He shows a lot of facts to prove that being a giver brings benefits for people and the doer as well. The objects of giving here comprise different kinds help like wealth, ideas, knowledge, skills and information. Therefore, he motivates people to become givers. In this connection, the reviewer would like to show that Islamic religion also motivates its followers to give helps to others. Though, there are some similarities and differences between the benefits of giving mentioned in the book and the verses of the Holy Qur’an and the sayings of Prophet Muhammad Peace be upon him.

  13. Electromagnetic signatures of far-field gravitational radiation in the 1 + 3 approach

    Chua, Alvin J K; Cañizares, Priscilla; Gair, Jonathan R

    2015-01-01

    Gravitational waves (GWs) from astrophysical sources can interact with background electromagnetic fields, giving rise to distinctive and potentially detectable electromagnetic signatures. In this paper, we study such interactions for far-field gravitational radiation using the 1 + 3 approach to relativity. Linearized equations for the electromagnetic field on perturbed Minkowski space are derived and solved analytically. The inverse Gertsenshteĭn conversion of GWs in a static electromagnetic field is rederived, and the resultant electromagnetic radiation is shown to be significant for highly magnetized pulsars in compact binary systems. We also obtain a variety of nonlinear interference effects for interacting gravitational and electromagnetic waves, although wave–wave resonances previously described in the literature are absent when the electric–magnetic self-interaction is taken into account. The fluctuation and amplification of electromagnetic energy flux as the GW strength increases towards the gravitational–electromagnetic frequency ratio is a possible signature of gravitational radiation from extended astrophysical sources. (paper)

  14. Our khowledge of radiation?

    Anon.

    1989-01-01

    Exposure pathways of natural source radiation on man are shown. Radiation earth sources give on an average more, than 5/6 of the year effective equivalent dose absorbed by population mainly due to the internal radiation. Radon and its decay products which are contained in many building materials and in water and natural gas as well, require particular attention. Necessity to carry out radiation control of building materias, as well as, other measures dealing with reduction of radon concentration in houses is underlined

  15. The Rise of the Digital Public Library

    McKendrick, Joseph

    2012-01-01

    There is a growing shift to digital offerings among public libraries. Libraries increasingly are fulfilling roles as technology hubs for their communities, with high demand for technology and career development training resources. Ebooks and other digital materials are on the rise, while print is being scaled back. More libraries are turning to…

  16. Rise time spectroscopy in cadmium telluride detectors

    Scharager, Claude; Siffert, Paul; Carnet, Bernard; Le Meur, Roger.

    1980-11-01

    By a simultaneous analysis of rise time and pulse amplitude distributions of the signals issued from various cadmium telluride detectors, it is possible to obtain informations about surface and bulk trapping, field distribution within the detectors, as well as charge collection and transport properties. These investigations have been performed on both pure and chlorine doped and materials for various surfaces preparation conditions [fr

  17. How oxygen gave rise to eukaryotic sex

    Hörandl, Elvira; Speijer, Dave

    2018-01-01

    9years ago. The large amount of ROS coming from a bacterial endosymbiont gave rise to DNA damage and vast increases in host genome mutation rates. Eukaryogenesis and chromosome evolution represent adaptations to oxidative stress. The host, an archaeon, most probably already had repair mechanisms

  18. Rising Political Consciousness: Transformational Learning in Malaysia.

    Kamis, Mazalan; Muhamad, Mazanah

    As part of a larger study (not discussed) ten educated Malaysian citizens were interviewed to find whether their rising political consciousness, over a ten year period (1988-1999), indicated that their transformation was influenced by their culture. The subjects were between 35-45 years old, married, with an average of four children. All were…

  19. Can income redistribution help changing rising inequality?

    Salverda, W.

    2014-01-01

    In this article compares the rise in inequality concerning net household incomes in a number of European countries and Canada, the USA and Australia. Two important factors are used to explain this worrying trend: a growing of unequal market incomes and/or a declining redistribution of income through

  20. Why does a spinning egg rise?

    Cross, Rod

    2018-03-01

    Experimental and theoretical results are presented concerning the rise of a spinning egg. It was found that an egg rises quickly while it is sliding and then more slowly when it starts rolling. The angular momentum of the egg projected in the XZ plane changed in the same direction as the friction torque, as expected, by rotating away from the vertical Z axis. The latter result does not explain the rise. However, an even larger effect arises from the Y component of the angular momentum vector. As the egg rises, the egg rotates about the Y axis, an effect that is closely analogous to rotation of the egg about the Z axis. Both effects can be described in terms of precession about the respective axes. Steady precession about the Z axis arises from the normal reaction force in the Z direction, while precession about the Y axis arises from the friction force in the Y direction. Precession about the Z axis ceases if the normal reaction force decreases to zero, and precession about the Y axis ceases if the friction force decreases to zero.

  1. Sea level rise : A literature survey

    Oude Essink, G.H.P.

    1992-01-01

    In order to assess the impact of sea level rise on Water Management, it is useful to understand the mechanisrns that determine the level of the sea. In this study, a literature survey is executed to analyze these mechanisms. Climate plays a centra! role in these mechanisms, Climate mainly changes

  2. Tube temperature rise limits: Boiling considerations

    Vanderwater, R.G.

    1952-03-26

    A revision of tube power limits based on boiling considerations was presented earlier. The limits were given on a basis of tube power versus header pressure. However, for convenience of operation, the limits have been converted from tube power to permissible water temperature rise. The permissible {triangle}t`s water are given in this document.

  3. The economic consequences of oil price rise

    Lescaroux, Francois

    2006-05-01

    The author discusses the possible consequences of oil barrel price rise. First, he discusses the main results of analysis's which have been performed for thirty years regarding the impact of oil price on economical activity. He proposes interpretations of these studies and of their conclusions, and tries to draw lessons regarding effects which can be expected from the recent evolutions of energy markets

  4. The Enigma of Mercury's Northern Rise

    James, P. B.

    2018-05-01

    Various aspects of the "northern rise" make it hard to explain: Its composition and chronology don't stand out from its surroundings, it seems to have uplifted late, and it has a huge gravity anomaly. We'll discuss the possible formation mechanisms.

  5. Propolis Supplementation and the Changes in the Oxidative Metabolism of Blood Platelets Exposed to Electromagnetic Radiation

    Henrykowska Gabriela

    2015-03-01

    Full Text Available Introduction. Electromagnetic radiation (EMR that has an effect on living organisms may be a source of oxidative stress. A lack of proper compensation by antioxidant defences on the part of proteins leading to an uncontrolled growth of reactive forms of oxygen, which may give rise to numerous health conditions. Various scientific studies have indicated that propolis has multiple valuable medicinal properties: antibacterial, anti-inflammatory, antioxidant, protective - in relation to liver parenchyma, as well as anti-cancer. Nonetheless, the results of studies concerned with its antioxidant capabilities are not explicit and require further tests and analyses.

  6. Integral method for the calculation of Hawking radiation in dispersive media. I. Symmetric asymptotics

    Robertson, Scott; Leonhardt, Ulf

    2014-11-01

    Hawking radiation has become experimentally testable thanks to the many analog systems which mimic the effects of the event horizon on wave propagation. These systems are typically dominated by dispersion and give rise to a numerically soluble and stable ordinary differential equation only if the rest-frame dispersion relation Ω2(k ) is a polynomial of relatively low degree. Here we present a new method for the calculation of wave scattering in a one-dimensional medium of arbitrary dispersion. It views the wave equation as an integral equation in Fourier space, which can be solved using standard and efficient numerical techniques.

  7. Duality of solar UV-B radiation and relevant dosimetry: vitamin D synthesis versus skin erythema

    Terenetskaya, Irina P.

    2003-06-01

    Solar ultraviolet radiation (UVR) gives rise to beneficial or adverse health effects depending on the dose. Excessive UV exposures are associated with acute and chronic health effect but in appropriate doses UV sunlight is advisable. Important biological function of UVR is initiation of endogenous synthesis of vitamin D in human skin. A useful method based on an in vitro model of vitamin D synthesis ('D-dosimeter') has been specially developed to measure the vitamin D synthetic capacity of sunlight in situ. For the first time laboratory and field tests have been performed to link commonly used erythemal units (MEDs) and previtamin D accumulation.

  8. Radiation effects and radiation risks

    Lengfelder, E.; Forst, D.; Feist, H.; Pratzel, H.

    1988-01-01

    The book presents the facts and the principles of assessment and evaluation of biological radiation effects in general and also with particular reference to the reactor accident of Chernobyl, reviewing the consequences and the environmental situation on the basis of current national and international literature, including research work by the authors. The material compiled in this book is intended especially for physicians, but will also prove useful for persons working in the public health services, in administration, or other services taking care of people. The authors tried to find an easily comprehensible way of presenting and explaining the very complex processes and mechanisms of biological radiation effects and carcinogenesis, displaying the physical primary processes and the mechanisms of the molecular radiation effects up to the effects of low-level radiation, and present results of comparative epidemiologic studies. This section has been given considerable space, in proportion to its significance. It also contains literature references for further reading, offering more insight and knowledge of aspects of special subject fields. The authors also present less known results and data and discuss them against the background of well-known research results and approaches. Apart from the purpose of presenting comprehensive information, the authors intend to give an impact for further thinking about the problems, and helpful tools for independent decisions and action on the basis of improved insight and assessment, and in this context particularly point to the problems induced by the Chernobyl reactor accident. (orig./MG) With 8 maps in appendix [de

  9. Depleted uranium. Protecting against all possible sources of ionizing radiation through the development and application of state-of-the-art safety standards

    2001-01-01

    Under its Statute the IAEA has the specific mandate to establish, in consultation and collaboration with other United Nations and specialized agencies concerned, standards for the protection against ionizing radiation and for the safety of radiation sources and to provide for the application of these standards. With respect to potential radiation hazards, the Agency has jointly developed the International Basic Safety Standards with the World Health Organization, and the Food and Agriculture Organization. These standards, known as the BSS, cover a wide range of situations that give rise or could give rise to exposure to radiation, such as the radiation hazard posed by depleted uranium (DU). Based on the information currently available, DU ammunitions do not appear to present a significant risk to health from a radiological point of view. Since only limited studies have been undertaken in post-conflict areas where DU ammunitions were used, further assessment and studies of DU in such areas would increase the confidence in this observation. In addition to radiological assessment, the IAEA is also developing a training course to assist Member States in analytical methods and techniques that could be used to detect and measure DU in post-conflict areas

  10. Updating Maryland's sea-level rise projections

    Boesch, Donald F.; Atkinson, Larry P.; Boicourt, William C.; Boon, John D.; Cahoon, Donald R.; Dalrymple, Robert A.; Ezer, Tal; Horton, Benjamin P.; Johnson, Zoe P.; Kopp, Robert E.; Li, Ming; Moss, Richard H.; Parris, Adam; Sommerfield, Christopher K.

    2013-01-01

    With its 3,100 miles of tidal shoreline and low-lying rural and urban lands, “The Free State” is one of the most vulnerable to sea-level rise. Historically, Marylanders have long had to contend with rising water levels along its Chesapeake Bay and Atlantic Ocean and coastal bay shores. Shorelines eroded and low-relief lands and islands, some previously inhabited, were inundated. Prior to the 20th century, this was largely due to the slow sinking of the land since Earth’s crust is still adjusting to the melting of large masses of ice following the last glacial period. Over the 20th century, however, the rate of rise of the average level of tidal waters with respect to land, or relative sea-level rise, has increased, at least partially as a result of global warming. Moreover, the scientific evidence is compelling that Earth’s climate will continue to warm and its oceans will rise even more rapidly. Recognizing the scientific consensus around global climate change, the contribution of human activities to it, and the vulnerability of Maryland’s people, property, public investments, and natural resources, Governor Martin O’Malley established the Maryland Commission on Climate Change on April 20, 2007. The Commission produced a Plan of Action that included a comprehensive climate change impact assessment, a greenhouse gas reduction strategy, and strategies for reducing Maryland’s vulnerability to climate change. The Plan has led to landmark legislation to reduce the state’s greenhouse gas emissions and a variety of state policies designed to reduce energy consumption and promote adaptation to climate change.

  11. Radiation chemistry

    Rodgers, F.; Rodgers, M.A.

    1987-01-01

    The contents of this book include: Interaction of ionizing radiation with matter; Primary products in radiation chemistry; Theoretical aspects of radiation chemistry; Theories of the solvated electron; The radiation chemistry of gases; Radiation chemistry of colloidal aggregates; Radiation chemistry of the alkali halides; Radiation chemistry of polymers; Radiation chemistry of biopolymers; Radiation processing and sterilization; and Compound index

  12. Control of ionising radiation - a UK viewpoint

    Shrimpton, P.C.

    1995-01-01

    The primary aim of radiological protection is to provide an appropriate standard of protection for mankind, both as individuals and collectively, without unduly limiting the beneficial practices giving rise to radiation exposure. Guidance on the fundamental principles for radiation protection is provided on a global scale by the International Commission on Radiological Protection (ICRP). Member states of the European Union, such as the UK, are bound by the Euratom Treaty that requires the Commission of the European Communities (CEC) to develop uniform standards for radiological protection. These standards are based on recommendations from ICRP and are laid down in Euratom Directives relating to the safety of workers and the public, and of patients undergoing medical exposures. Member states are required to introduce national legislation to comply with Directives. In addition to ICRP and CEC, other international bodies are involved in developing practical standards and guidelines for radiological protection. For example, the International Atomic Energy Agency (IAEA) provides guidelines relating to the transport of radioactive material, and the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) provides information on the biological effects of radiation. In the UK, the National Radiological Protection Board (NRPB) was established in 1970 as a statutory advisory body. It has no regulatory functions. NRPB advises Government on the acceptability and applicability of international recommendations. Principles are then applied in the UK by Acts of Parliament and subsidiary instruments such as regulations, licences, authorizations and approvals. Various government departments are involved in policing the control of radiation according to their particular role, for example the Department of the Environment in relation to pollution, and the Department of Employment for the health and safety of workers. (author)

  13. Biological dosimetry in cases gives occupational high exposition to ionizing radiations

    Ramalho, Adriana T.; Costa, Maria Lucia P.; Oliveira, Monica S.; Silva, Francisco Cesar A.

    1998-01-01

    From 1983 the cytogenetics dosimetry method it has been used as routine in the IRD laboratory in the period 1983 at 1997 but a high exposition occupational case the physical dosimeters happened in Brazil they were investigated through the cytogenetics dosimetry technique. This technique is employ when the dosimetry personal marks a high dose to 100 mSv (0,1 Gy) that is the cut-off minimum detected in the dosimetry cytogenetics

  14. Testing for altruism and social pressure in charitable giving.

    DellaVigna, Stefano; List, John A; Malmendier, Ulrike

    2012-01-01

    Every year, 90% of Americans give money to charities. Is such generosity necessarily welfare enhancing for the giver? We present a theoretical framework that distinguishes two types of motivation: individuals like to give, for example, due to altruism or warm glow, and individuals would rather not give but dislike saying no, for example, due to social pressure. We design a door-to-door fund-raiser in which some households are informed about the exact time of solicitation with a flyer on their doorknobs. Thus, they can seek or avoid the fund-raiser. We find that the flyer reduces the share of households opening the door by 9% to 25% and, if the flyer allows checking a Do Not Disturb box, reduces giving by 28% to 42%. The latter decrease is concentrated among donations smaller than $10. These findings suggest that social pressure is an important determinant of door-to-door giving. Combining data from this and a complementary field experiment, we structurally estimate the model. The estimated social pressure cost of saying no to a solicitor is $3.80 for an in-state charity and $1.40 for an out-of-state charity. Our welfare calculations suggest that our door-to-door fund-raising campaigns on average lower the utility of the potential donors.

  15. Social Relations of Fieldwork: Giving Back in a Research Setting

    Clare Gupta

    2014-07-01

    Full Text Available The project of this special issue emerged from the guest editors' experiences as field researchers in sub-Saharan Africa. During this time both researchers faced the difficult question of "giving back" to the communities in which, and with whom, they worked—communities that were often far less privileged than the researchers were in terms of wealth, mobility, education, and access to health care. Returning from their field sites, both researchers felt a combination of guilt and frustration that they had not done enough or had not done things right. Thus emerged the idea of bringing together a group of researchers, from a range of disciplines, to discuss the topic of giving back in field research. This editorial describes the idea and process that led to the present collection of articles. The guest editors situate the project in the literature on feminist studies and briefly summarize each of the four thematic sections in this special issue. They conclude by emphasizing that their collection is not a guide to giving back. Rather than lay out hard and fast rules about what, how much, and to whom field researchers should give, their collection offers a series of examples and considerations for giving back in fieldwork.

  16. Authorization gives the personnel he/she gives the center he/she gives Isotopes for the acting he/she gives tied functions with the security and the radiological protection

    Perez Pijuan, S.; Hernandez Alvarez, R.; Peres Reyes, Y.; Venegas Bernal, M.C.

    1998-01-01

    The conception is described used in a center production labelled compound and radiopharmaceuticals for the authorization to the support, operation and supervision personnel The approaches are exposed used to define the excellent positions for the security the installation. The are described the training programs, designed starting from the indentification the specific competitions for each duty station and with particular emphasis in the development gives abilities you practice. It is used for the administration and evaluation gives the programs training the Automated System Administration Programs Training (GESAT)

  17. Gift-giving in the medical student--patient relationship.

    Alamri, Yassar Abdullah S

    2012-08-01

    There is paucity in the published literature that provides any ethical guidance guiding gift-giving within the student--patient relationship. This is perhaps because the dynamics of the medical student--patient relationship have not yet been explored as extensively as the doctor--patient relationship. More importantly, however, gift--giving in the doctor-patient relationship has traditionally been from the patient to the doctor and not vice versa. This article examines the literature published in this vicinity reflecting on an encounter with a patient.

  18. EVALUATION OF SERVICE QUALITY OF AIRWAY COMPANIES GIVING DOMESTIC SERVICES IN TURKEY WITH FUZZY SET APPROACH

    H. Handan DEMIR

    2013-01-01

    Full Text Available Today, service quality has become a major phenomenon with the requirement of meeting consumer demands in the best way brought along with the rising competition between companies. Airway transportation is preferred more and more during the recent years. Many qualitative and quantitative criteria are considered while evaluating service criteria in airway transportation. In this context, evaluation of service quality is a decisionmaking problem with many criteria. The purpose of this study is to evaluate service quality of domestic airway companies in Turkey. In this study; fuzzy TOPSIS method which is one of the most preferred fuzzy MCDM methods, extension of multi criteria decision making methods in fuzzy environments, considering qualitative and quantitative criteria together and giving opportunity to make group decisions in fuzzy environments. As a result, evaluation was made based on service quality criteria for the most preferred airways companies in Turkey and these companies were ranked according to their levels of service quality.

  19. The risks associated with consumer magazines giving advice on complementary therapies.

    Mantle, Fiona

    The increased popularity of complementary and alternative medicine (CAM) has led to increased demand for information on it, giving rise to the concept of "new experts". However, there is concern about the quality and accuracy of this information, much of which is published in popular magazines and written by contributors with no medical qualifications. To examine the extent of CAM product advice in women's and health magazines, and the potential for adverse drug/herbal interaction. Fifteen women's magazines were examined over one month. A total of 150 articles were identified, of which 131 were written by non-medically qualified contributors, mainly journalists. Out of the 150, 95 discussed ingested herbs which had the potential for adverse interactions and are contraindicated for certain groups. The findings have legal and ethical implications. The re-evaluation of the journalists' code of conduct to reflect this development in journalism should be considered.

  20. Metformin: A Novel Biological Modifier of Tumor Response to Radiation Therapy

    Koritzinsky, Marianne, E-mail: mkoritzi@uhnresearch.ca

    2015-10-01

    Over the last decade, evidence has emerged to support a role for the antidiabetic drug metformin in the prevention and treatment of cancer. In particular, recent studies demonstrate that metformin enhances tumor response to radiation in experimental models, and retrospective analyses have shown that diabetic cancer patients treated with radiation therapy have improved outcomes if they take metformin to control their diabetes. Metformin may therefore be of utility for nondiabetic cancer patients treated with radiation therapy. The purpose of this review is to examine the data pertaining to an interaction between metformin and radiation, highlighting the essential steps needed to advance our current knowledge. There is also a focus on key biomarkers that should accompany prospective clinical trials in which metformin is being examined as a modifying agent with radiation therapy. Existing evidence supports that the mechanism underlying the ability of metformin to enhance radiation response is multifaceted, and includes direct radiosensitization as well as a reduction in tumor stem cell fraction, proliferation, and tumor hypoxia. Interestingly, metformin may enhance radiation response specifically in certain genetic backgrounds, such as in cells with loss of the tumor suppressors p53 and LKB1, giving rise to a therapeutic ratio and potential predictive biomarkers.

  1. Metformin: A Novel Biological Modifier of Tumor Response to Radiation Therapy

    Koritzinsky, Marianne

    2015-01-01

    Over the last decade, evidence has emerged to support a role for the antidiabetic drug metformin in the prevention and treatment of cancer. In particular, recent studies demonstrate that metformin enhances tumor response to radiation in experimental models, and retrospective analyses have shown that diabetic cancer patients treated with radiation therapy have improved outcomes if they take metformin to control their diabetes. Metformin may therefore be of utility for nondiabetic cancer patients treated with radiation therapy. The purpose of this review is to examine the data pertaining to an interaction between metformin and radiation, highlighting the essential steps needed to advance our current knowledge. There is also a focus on key biomarkers that should accompany prospective clinical trials in which metformin is being examined as a modifying agent with radiation therapy. Existing evidence supports that the mechanism underlying the ability of metformin to enhance radiation response is multifaceted, and includes direct radiosensitization as well as a reduction in tumor stem cell fraction, proliferation, and tumor hypoxia. Interestingly, metformin may enhance radiation response specifically in certain genetic backgrounds, such as in cells with loss of the tumor suppressors p53 and LKB1, giving rise to a therapeutic ratio and potential predictive biomarkers

  2. Long-term biological effects induced by ionizing radiation--implications for dose mediated risk.

    Miron, S D; Astărăstoae, V

    2014-01-01

    Ionizing radiations are considered to be risk agents that are responsible for the effects on interaction with living matter. The occurring biological effects are due to various factors such as: dose, type of radiation, exposure time, type of biological tissue, health condition and the age of the person exposed. The mechanisms involved in the direct modifications of nuclear DNA and mitochondrial DNA are reviewed. Classical target theory of energy deposition in the nucleus that causes DNA damages, in particular DNA double-strand breaks and that explanation of the biological consequences of ionizing radiation exposure is a paradigm in radiobiology. Recent experimental evidences have demonstrated the existence of a molecular mechanism that explains the non-targeted effects of ionizing radiation exposure. Among these novel data, genomic instability and a variety of bystander effects are discussed here. Those bystander effects of ionizing radiation are fulfilled by cellular communication systems that give rise to non-targeted effects in the neighboring non irradiated cells. This paper provides also a commentary on the synergistic effects induced by the co-exposures to ionizing radiation and various physical agents such as electromagnetic fields and the co-exposures to ionizing radiation and chemical environmental contaminants such as metals. The biological effects of multiple stressors on genomic instability and bystander effects are also discussed. Moreover, a brief presentation of the methods used to characterize cyto- and genotoxic damages is offered.

  3. Rise of oil prices and energy policy

    2005-01-01

    This document reprints the talk of the press conference given by D. de Villepin, French prime minister, on August 16, 2005 about the alarming rise of oil prices. In his talk, the prime minister explains the reasons of the crisis (increase of worldwide consumption, political tensions in the Middle East..) and presents the strategy and main trends of the French energy policy: re-launching of energy investments in petroleum refining capacities and in the nuclear domain (new generation of power plants), development of renewable energy sources and in particular biofuels, re-launching of the energy saving policy thanks to financial incentives and to the development of clean vehicles and mass transportation systems. In a second part, the prime minister presents his policy of retro-cession of petroleum tax profits to low income workers, and of charge abatement to professionals having an occupation strongly penalized by the rise of oil prices (truckers, farmers, fishermen, taxi drivers). (J.S.)

  4. High and rising health care costs.

    Ginsburg, Paul B

    2008-10-01

    The U.S. is spending a growing share of the GDP on health care, outpacing other industrialized countries. This synthesis examines why costs are higher in the U.S. and what is driving their growth. Key findings include: health care inefficiency, medical technology and health status (particularly obesity) are the primary drivers of rising U.S. health care costs. Health payer systems that reward inefficiencies and preempt competition have impeded productivity gains in the health care sector. The best evidence indicates medical technology accounts for one-half to two-thirds of spending growth. While medical malpractice insurance and defensive medicine contribute to health costs, they are not large enough factors to significantly contribute to a rise in spending. Research is consistent that demographics will not be a significant factor in driving spending despite the aging baby boomers.

  5. Compton suppression through rise-time analysis

    Selvi, S.; Celiktas, C.

    2007-01-01

    We studied Compton suppression for 60 Co and 137 Cs radioisotopes using a signal selection criterion based on contrasting the fall time of the signals composing the photo peak with those composing the Compton continuum. The fall time criterion is employed by using the pulse shape analysis observing the change in the fall times of the gamma-ray pulses. This change is determined by measuring the changes in the rise times related to the fall time of the scintillator and the timing signals related to the fall time of the input signals. We showed that Compton continuum suppression is achieved best via the precise timing adjustment of an analog rise-time analyzer connected to a NaI(Tl) scintillation spectrometer

  6. Analysis gives the penal treatment in Cuba to the tied infractions to the use and conservation gives radioactive substances

    Perez Gonzalez, F.; Perez Velazquez, R.S.; Fornet, R.O.; Reyes Fajardo, E.

    1998-01-01

    The work refers the realized analysis to the Law 62 the Cuban penal code that with establishing to the treatment of the infractions referred standard's to the uses and conservation the radioactive substances and other ionizing radiations sources

  7. The rise of precarious employment in Germany

    Brady, David; Biegert, Thomas

    2017-01-01

    Long considered the classic coordinated market economy featuring employment security and relatively little employment precarity, the German labor market has undergone profound changes in recent decades. We assess the evidence for a rise in precarious employment in Germany from 1984 to 2013. Using data from the German Socio-Economic Panel (SOEP) through the Luxembourg Income Study, we examine low-wage employment, working poverty, and temporary employment. We also analyze changes in the demogra...

  8. Rising sea levels and small island states

    Leatherman, S.P.

    1994-01-01

    A review is given of the problems small island nations face with respect to sea level rise caused by global warming. Many small island nations are very vulnerable to sea level rise. Particularly at risk are coral reef atolls, which are generally quite small, lie within three metres of current sea levels, and have no land at higher elevations to relocate populations and economic activity. Volcanic islands in the Pacific have high ground, but it is largely rugged, high relief and soil-poor. The most vulnerable islands are those that consist entirely of atolls and reef islands, such as Kirabai, Maldives, Tokelau and Tuvalu. Small island states, which by themselves have little power or influence in world affairs, have banded together to form the Strategic Alliance of Small Island States (AOSIS). This alliance had grown to include 42 states by the time of the 1992 U.N. Earth Summit. Although the greenhouse effect is mainly caused by industrial nations, developing countries will suffer the most from it. Choices of response strategy will depend on environmental, economic and social factors. Most small island nations do not have the resources to fight sea level rise in the way that the Dutch have. Retreat can occur as a gradual process or as catastrophic abandonment. Prohibiting construction close to the water's edge is a good approach. Sea level histories for each island state should be compiled and updated, island geomorphology and settlement patterns should be surveyed to determine risk areas, storm regimes should be determined, and information on coastal impacts of sea level rise should be disseminated to the public

  9. Rugged calorimeter with a fast rise time

    McMurtry, W.M.; Dolce, S.R.

    1980-01-01

    An intrinsic 1-mil-thick gold foil calorimeter has been developed which rises to 95% of the energy deposited in less than 2 microseconds. This calorimeter is very rugged, and can withstand rough handling without damage. The time constant is long, in the millisecond range, because of its unique construction. Use of this calorimeter has produced 100% data recovery, and agreement with true deposition to less than 10%

  10. Radiation-induced thermoacoustic imaging

    Bowen, T.

    1984-01-01

    This invention provides a new technique for obtaining information non-invasively on the composition and structures of a material or body by detecting radiation-induced thermoacoustic image features. This is accomplished by utilizing the acoustic wave generated by sudden thermal stress. The sudden thermal stress is induced by a pulse of radiation which deposits energy causing a rapid, but very small, rise of temperature (typically, ΔT approximately 10sup(-6) - 10sup(-5) deg C). The radiation may be ionizing radiation, such as high energy electrons, photons (x-rays), neutrons, or other charged particles or it may be non-ionizing radiation, such as R.F. and microwave electromagnetic radiation and ultrasonic radiation. The choice of radiation depends on the nature of the body to be imaged and the type of information desired

  11. At the Crossroads of Cancer Stem Cells, Radiation Biology, and Radiation Oncology.

    Gerweck, Leo E; Wakimoto, Hiroaki

    2016-03-01

    Reports that a small subset of tumor cells initiate and sustain tumor growth, are resistant to radiation and drugs, and bear specific markers have led to an explosion of cancer stem cell research. These reports imply that the evaluation of therapeutic response by changes in tumor volume is misleading, as volume changes reflect the response of the sensitive rather than the resistant tumorigenic cell population. The reports further suggest that the marker-based selection of the tumor cell population will facilitate the development of radiation treatment schedules, sensitizers, and drugs that specifically target the resistant tumorigenic cells that give rise to treatment failure. This review presents evidence that contests the observations that cancer stem cell markers reliably identify the subset of tumor cells that sustain tumor growth and that the marker-identified population is radioresistant relative to the marker-negative cells. Experimental studies show that cells and tumors that survive large radiation doses are not more radioresistant than unirradiated cells and tumors, and also show that the intrinsic radiosensitivity of unsorted colony-forming tumor cells, in combination with the fraction of unsorted tumor cells that are tumor initiating, predicts tumor radiocurability. ©2016 American Association for Cancer Research.

  12. Radiation hormesis

    Hattori, Sadao; Nemoto, Kazuyasu; Ishida, Kenzi; Misonoo, Jun; Suganuma, Hirotoshi; Ishi, Keiichirou; Yamaoka, Kiyonori

    1990-01-01

    Greater attention has recently been drawn to the hormesis effect of radiations on living things. An agent is said to show hormesis when it gives a favorable physiological stimulation to living things and activated their biological functions if used in slight amounts, though it has an adverse effect on them if used in large amount. Recently many reports have been published which insist that radiations in a certain low dose range can have favorable biological effects, such as stimulation and activation, on living things including humans, animals and plants. Thus hormesis can be seen very widely in the biological field. The report first describes recent trends in research in this field, including the background behind the proposal of the radiation hormesis hypothesis, and major studies presented at the Oakland and Frankfurt Conferences. Then it outlines major research efforts that have been made at Denryoku Chuo Kenkyusho in Japan, focusing on animal tests (superoxidedismutase activity, thymidinekinase activity, etc.), immunological surveys, and plant tests. Discussion is also made concerning important issues and study subjects to be covered in future research. (N.K.)

  13. Sea-level rise: towards understanding local vulnerability

    Rahmstorf, Stefan

    2012-06-01

    Projections of global sea-level rise into the future have become more pessimistic over the past five years or so. A global rise by more than one metre by the year 2100 is now widely accepted as a serious possibility if greenhouse gas emissions continue unabated. That is witnessed by the scientific assessments that were made since the last IPCC report was published in 2007. The Delta Commission of the Dutch government projected up to 1.10 m as a 'high-end' scenario (Vellinga et al 2009). The Scientific Committee on Antarctic Research (SCAR) projected up to 1.40 m (Scientific Committee on Antarctic Research 2009), and the Arctic Monitoring and Assessment Programme (AMAP) gives a range of 0.90-1.60 m in its 2011 report (Arctic Monitoring and Assessment Programme 2011). And recently the US Army Corps of Engineers recommends using a 'low', an 'intermediate' and a 'high' scenario for global sea-level rise when planning civil works programmes, with the high one corresponding to a 1.50 m rise by 2100 (US Army Corps of Engineers 2011). This more pessimistic view is based on a number of observations, most importantly perhaps the fact that sea level has been rising at least 50% faster in the past decades than projected by the IPCC (Rahmstorf et al 2007, IPCC 2007). Also, the rate of rise (averaged over two decades) has accelerated threefold, from around 1 mm yr-1 at the start of the 20th century to around 3 mm yr-1 over the past 20 years (Church and White 2006), and this rate increase closely correlates with global warming (Rahmstorf et al 2011). The IPCC projections, which assume almost no further acceleration in the 20th century, thus look less plausible. And finally the observed net mass loss of the two big continental ice sheets (Van den Broeke et al 2011) calls into question the assumption that ice accumulation in Antarctica would largely balance ice loss from Greenland in the course of further global warming (IPCC 2007). With such a serious sea-level rise on the horizon

  14. Better by the Year. The FRI Annual Giving Book.

    Williams, M. Jane

    Designed for a nonprofit organization executive, this book suggests how to start and run an increasingly profitable program for attracting the kind of gifts that will be repeated year after year. Preliminary preparations, the launch and administration of a campaign, four ways to reach higher goals, and annual giving ideas from education, health…

  15. Give me a break!: Informal caregiver attitudes towards respite care

    van Exel, J..; de Graaf, G.; Brouwer, W.B.F.

    2009-01-01

    Background/objective: Because informal health care is now recognized to be indispensable to health care systems, different forms of respite care have been developed and publicly funded that supposedly alleviate caregivers' perceived burdens and help prolong the care giving task. Nonetheless, the use

  16. Improving Evidence on Private Giving in Emerging Economies ...

    ... gaps on amounts and sources. There is also a lack of research on regulations and policies that support or discourage private giving. This research project will explore philanthropic cooperation in emerging and developing country contexts by quantifying financial flows from emerging economies to developing countries.

  17. Why do firms give away their patents for free?

    Ziegler, Nicole; Gassmann, Oliver; Friesike, Sascha

    2013-01-01

    Within the trend of increasing patent commercialisation and open innovation, a recent phenomenon where firms give away their patents free of charge can be observed. This seems contradictory to the original intention of the patent system (enabling firms to create temporary monopolies to appropriate

  18. Giving Voice: A Course on American Indian Women.

    Krouse, Susan Applegate

    1997-01-01

    Presents the story of the creation of an undergraduate course on the traditional and contemporary roles of women in North American Indian cultures. Notes that the course was designed around experiential learning precepts and the idea of "giving voice" to American Indian women. Lists texts used and evaluates course strengths. (DSK)

  19. A Conversation Model Enabling Intelligent Agents to Give Emotional Support

    Van der Zwaan, J.M.; Dignum, V.; Jonker, C.M.

    2012-01-01

    In everyday life, people frequently talk to others to help them deal with negative emotions. To some extent, everybody is capable of comforting other people, but so far conversational agents are unable to deal with this type of situation. To provide intelligent agents with the capability to give

  20. Giving Back — IDRC photo contest winner shares prize with ...

    2011-01-28

    Jan 28, 2011 ... Giving Back — IDRC photo contest winner shares prize with Senegalese colleagues ... South or the developed world are tackling the challenges of urban living. ... Upon his return to Canada, the 26-year-old wrote to IDRC the ...

  1. Advice-giving in the English lingua franca classroom

    important pragmatic differences between the ways in which advice is given by native speakers and ... gender differences and that teacher modeling may have an effect on which available form of advice-giving a ... nation wishes to participate in global enterprises such as international finance, multi-national corporations, and ...

  2. Neurocultural evidence that ideal affect match promotes giving.

    Park, BoKyung; Blevins, Elizabeth; Knutson, Brian; Tsai, Jeanne L

    2017-07-01

    Why do people give to strangers? We propose that people trust and give more to those whose emotional expressions match how they ideally want to feel ("ideal affect match"). European Americans and Koreans played multiple trials of the Dictator Game with recipients who varied in emotional expression (excited, calm), race (White, Asian) and sex (male, female). Consistent with their culture's valued affect, European Americans trusted and gave more to excited than calm recipients, whereas Koreans trusted and gave more to calm than excited recipients. These findings held regardless of recipient race and sex. We then used fMRI to probe potential affective and mentalizing mechanisms. Increased activity in the nucleus accumbens (associated with reward anticipation) predicted giving, as did decreased activity in the right temporo-parietal junction (rTPJ; associated with reduced belief prediction error). Ideal affect match decreased rTPJ activity, suggesting that people may trust and give more to strangers whom they perceive to share their affective values. © The Author (2017). Published by Oxford University Press.

  3. IMPROVING WOMEN'S LIVES Practical support for women gives ...

    IMPROVING WOMEN'S LIVES Practical support for women gives communities a better future. October 26 ... Organized into small cooperatives, the women produce and market argan oil using a mix of traditional and modern methods. At the same time ... arts and craft. Technology helps Asian women balance family and work.

  4. Reprint of: Bidding to give in the field

    Onderstal, S.; Schram, A.J.H.C.; Soetevent, A.R.

    2014-01-01

    In a door-to-door fundraising field experiment, we study the impact of fundraising mechanisms on charitable giving. We approached about 4500 households, each participating in an all-pay auction, a lottery, a non-anonymous voluntary contribution mechanism (VCM), or an anonymous VCM. In contrast to

  5. Reprint of : Bidding to give in the field

    Onderstal, Sander; Schram, Arthur J. H. C.; Soetevent, Adriaan R.

    In a door-to-door fundraising field experiment, we study the impact of fundraising mechanisms on charitable giving. We approached about 4500 households, each participating in an all-pay auction, a lottery, a non-anonymous voluntary contribution mechanism (VCM), or an anonymous VCM. In contrast to

  6. Mensurations give the radioactivity natural gamma, radon in Chile

    Gamarra, J.; Stuardo, E.

    1998-01-01

    In this work, are presented the methods for measurement, calculate and you discusses the results, in each studied area, in the mark the respective world averages. None the averages evaluated annual effective dose they surpassed these world averages effective dose or level gives intervention, corresponding

  7. Exploring gender differences in charitable giving : The Dutch Case

    De Wit, Arjen; Bekkers, René

    2016-01-01

    Women’s philanthropy has drawn much attention during recent years, mostly in studies from the United States or the United Kingdom. Relevant issues are to what extent gender differences in charitable giving exist in another national context and how these differences can be explained. In this study,

  8. The good news about giving bad news to patients.

    Farber, Neil J; Urban, Susan Y; Collier, Virginia U; Weiner, Joan; Polite, Ronald G; Davis, Elizabeth B; Boyer, E Gil

    2002-12-01

    There are few data available on how physicians inform patients about bad news. We surveyed internists about how they convey this information. We surveyed internists about their activities in giving bad news to patients. One set of questions was about activities for the emotional support of the patient (11 items), and the other was about activities for creating a supportive environment for delivering bad news (9 items). The impact of demographic factors on the performance of emotionally supportive items, environmentally supportive items, and on the number of minutes reportedly spent delivering news was analyzed by analysis of variance and multiple regression analysis. More than half of the internists reported that they always or frequently performed 10 of the 11 emotionally supportive items and 6 of the 9 environmentally supportive items while giving bad news to patients. The average time reportedly spent in giving bad news was 27 minutes. Although training in giving bad news had a significant impact on the number of emotionally supportive items reported (P woman, unmarried, and having a history of major illness were also associated with reporting a greater number of emotionally supportive activities. Internists report that they inform patients of bad news appropriately. Some deficiencies exist, specifically in discussing prognosis and referral of patients to support groups. Physician educational efforts should include discussion of prognosis with patients as well as the availability of support groups.

  9. Using "The Giving Tree" To Teach Literary Criticism.

    Remler, Nancy Lawson

    2000-01-01

    Argues that introducing students to literary criticism while introducing them to literature boosts their confidence and abilities to analyze literature, and increases their interest in discussing it. Describes how the author, in her college-level introductory literature course, used Shel Silverstein's "The Giving Tree" (a children's…

  10. Reciprocity Revisited : Give and Take in Dutch and Immigrant Families

    Komter, Aafke; Schans, Djamila

    2008-01-01

    The idea that reciprocity is the basic principle underlying forms of social organization, among which the family, is as old as classical anthropology and sociology. The essence of the principle is that giving prompts receiving, thereby creating forms of ongoing exchange and durable cooperation.

  11. The genus Architeuthis was erected, without giving any diagnosis ...

    spamer

    The genus Architeuthis was erected, without giving any diagnosis, by Steenstrup in 1857 for a specimen stranded on the Danish coast in 1853. In 1880, Verrill gave the first description of the genus. Pfeffer (1912) related this history and also mentioned that traditional narratives and illustrations of the 16th century had.

  12. Radiation and radiation protection

    Landfermann, H.H.; Solbach, C.

    1992-11-01

    The brochure explains the major types of radiation, the radiation sources, effects, uses, and risks, as well as the regulatory system adopted by the government in order to keep the risks as low as possible. (orig./DG) [de

  13. Radiation: Basic life for human

    Wan Saffiey Wan Abdullah

    2009-01-01

    Basically, radiation is sources for everything in this world. From radiation, many reactions and activities can be done by organisms. The tree can do photosynthesis and at the same time can give oxygen to human and others. In Quran, radiation was mentioned almost 41 times and from that, 12 are preferred to sun, moon, and stars. Radiation can be classified into two groups, mechanical and electromagnetic. Mechanical radiations are produced from vibration process. For example, when we are talking, sound radiation will be produced from vibration of sounds box. The guitar will sounded when we pluck it. Generally, mechanical radiation needs medium for its propagation and the velocity of wave can change and it cannot propagate in vacuum states. Meanwhile, electromagnetic radiations are energy that emitted in wave produced by propagation of electrical charges. This will produce magnetic fields and then if these fields changed, electrical fields will produce. There are two types of radiation in human life, natural radiation and artificially radiation. Radiation can be applied in medical and defend sector. Radiation also can be misuse by some people that want it for other purpose in intention to do something wrong, such as in making bomb and others weapons. In Malaysia, there are one act to control the imports, exports, licensing, transferring and application of ionizing radiation but not for non-ionizing radiation. In future, laser radiations have their own potential to become one of the most important radiations in renewable energy sector, medical and defend.

  14. The Radiation Protection Act

    Persson, L.

    1989-01-01

    The new Radiation Protection Act (1988:220) entered into force in Sweden on July 1st, 1988. This book presents the Act as well as certain regulations connected to it. As previously, the main responsibility for public radiation protection will rest with one central radiation protection authority. According to the 1988 Act, the general obligations with regard to radiation protection will place a greater responsibility than in the past on persons carrying out activities involving radiation. Under the act, it is possible to adjust the licensing and supervisory procedures to the level of danger of the radiation source and the need for adequate competence, etc. The Act recognises standardised approval procedures combined with technical regulations for areas where the risks are well known. The Act contains several rules providing for more effective supervision. The supervising authority may in particular decide on the necessary regulations and prohibitions for each individual case. The possibilities of using penal provisions have been extended and a rule on the mandatory execution of orders has been introduced. The Ordinance on Radiation Protection (1988:293) designates the National Institute of Radiation Protection (SSI) as the central authority referred to in the Radiation Protection Act. The book also gives a historic review of radiation protection laws in Sweden, lists regulations issued by SSI and presents explanations of radiation effects and international norms in the area. (author)

  15. Informal care giving to more disabled people with multiple sclerosis.

    Buchanan, Robert J; Radin, Dagmar; Chakravorty, Bonnie J; Tyry, Tuula

    2009-01-01

    About 30% of the people with multiple sclerosis (MS) require some form of home care assistance and 80% of that assistance is provided by informal or unpaid care givers. This study focusses on the care givers for 530 more disabled people with MS, with the objective of learning more about informal care giving to people with greater dependency and need for assistance. The data presented in this study were collected in a national survey of 530 people who provided informal care to more disabled people with MS. Almost half of these care givers reported that they provided more than 20 h of care per week to the person with MS, with more than 9 in 10 shopping for groceries, doing indoor housework, preparing meals or providing transportation for the person with MS. More than 4 in 10 employed care givers reduced the amount of time worked in the previous 12 months because of their care giving responsibilities. Although more than half of the MS care givers in our study reported that care giving was demanding, time consuming or challenging, about 90% of these MS care givers were happy that they could help. About two in three of these MS care givers found that care giving was rewarding, with more than 8 in 10 proud of the care they provided. More than a quarter of the informal care givers to people with MS thought they would benefit from treatment or counselling provided by mental health professionals. Not only it is necessary to provide access to mental health services for people with MS, but it is also important to assure that their informal care givers also have access to appropriate mental health care, given the scope of their care giving responsibilities.

  16. Give me a break! Informal caregiver attitudes towards respite care.

    van Exel, Job; de Graaf, Gjalt; Brouwer, Werner

    2008-10-01

    Because informal health care is now recognized to be indispensable to health care systems, different forms of respite care have been developed and publicly funded that supposedly alleviate caregivers' perceived burdens and help prolong the care giving task. Nonetheless, the use of respite care services is low even among substantially strained caregivers. To throw light on this low usage, this paper explores the associations between attitudes towards respite care, characteristics of the care giving situation, and the need and use of respite care. The survey, administered to a sample of 273 informal caregivers, addressed caregiver, care recipient, and care giving situation characteristics, as well as the familiarity and use of respite care services. It also included a sub-set of 12 statements eliciting attitudes towards respite care from an earlier study [Van Exel NJA, De Graaf G, Brouwer WBF. Care for a break? An investigation of informal caregivers' attitudes toward respite care using Q-methodology. Health Policy 2007;83(2/3):332-42]. Associations between variables were measured using univariate statistics and multinomial logistic regression. We found three caregiver attitudes, distributed fairly equally in the sample, that are apparently associated with caregiver educational level, employment status, health and happiness, as well as care recipient gender, duration and intensity of care giving, relationship, co-residence, need for surveillance, and subjective burden and process utility of care giving. However, the relation between attitude and familiarity with and use of respite care services is ambiguous. Although further exploration is needed of the mix of Q-methodology and survey analysis, the overall results indicate that a considerable portion of the caregiver population needs but does not readily ask for support or respite care. This finding has important policy implications in the context of an ageing population.

  17. The effects of the Boussinesq model to the rising of the explosion clouds

    Li Xiaoli; Zheng Yi

    2010-01-01

    It is to study the rising of the explosion clouds in the normal atmosphere using Boussinesq model and the Incompressible model, the numerical model is based on the assumption that effects the clouds are gravity and buoyancy. By comparing the evolvement of different density cloud, and gives the conclusion-the Boussinesq model and the Incompressible model is accord when the cloud's density is larger compared to the density of the environment. (authors)

  18. Radiation measurement

    Go, Sung Jin; Kim, Seung Guk; No, Gyeong Seok; Park, Myeong Hwan; Ann, Bong Seon

    1998-03-01

    This book explains technical terms about radiation measurement, which are radiation, radiation quantity and unit such as prefix of international unit, unit for defence purposes of radiation, coefficient of radiation and interaction, kinds and principles of radiation detector, ionization chamber, G-M counter, G-M tube, proportional counter, scintillation detector, semiconductor radiation detector, thermoluminescence dosimeter, PLD, others detector, radiation monitor, neutron detector, calibration of radiation detector, statistics of counting value, activation analysis and electronics circuit of radiation detector.

  19. SU-F-T-683: Cancer Stem Cell Hypothesis and Radiation Treatments

    Fourkal, E

    2016-01-01

    Purpose: The tumor control probability in radiation therapy allows comparing different radiation treatments to each other by means of calculating the probability that a prescribed dose of radiation eradicates or controls the tumor. In the conventional approach, all cancer cells can divide unlimited number of times and the tumor control often means eradicating every malignant cell by the radiation. In recent years however, there is a mounting consensus that in a given tumor volume there is a sub-population of cells, known as cancer stem cells (CSCs) that are responsible for tumor initiation and growth. Other or progenitor cancer cells can only divide limited number of times. This entails that only cancer stem cells may nned to be eliminated in order to control the tumor. Thus one may define TCP as the probability of eliminating CSCs for the given dose of radiation. Methods: Using stochastic methods, specifically the birth-and-death Markov processes, an infinite system of equations is set for probabilities of having m cancer stem cells at time t after the start of radiation. The TCP is calculated as the probability of no cancer stem cells surviving the radiation. Two scenarios are studied. In the first situation, the TCP is calculated for a unidirectional case when CSC gives birth to another CSC or a progenitor cell. In the second scenario, a bidirectional model is studied where the progenitor cell gives rise to CSC. Results: The proposed calculations show that the calculated TCP for CSC depends on whether one adopts unidirectional or bidirectional conversion models. The bidirectional model shows significantly lower TCP values for the given dose delivered to the tumor. Conclusion: Incorporating CSC hypothesis into the TCP modeling may notably influence the dose prescription as well as the concept of the expected TCP after the radiation treatments.

  20. SU-F-T-683: Cancer Stem Cell Hypothesis and Radiation Treatments

    Fourkal, E [Pinnacle Health Cancer Center, Harrisburg, PA (United States)

    2016-06-15

    Purpose: The tumor control probability in radiation therapy allows comparing different radiation treatments to each other by means of calculating the probability that a prescribed dose of radiation eradicates or controls the tumor. In the conventional approach, all cancer cells can divide unlimited number of times and the tumor control often means eradicating every malignant cell by the radiation. In recent years however, there is a mounting consensus that in a given tumor volume there is a sub-population of cells, known as cancer stem cells (CSCs) that are responsible for tumor initiation and growth. Other or progenitor cancer cells can only divide limited number of times. This entails that only cancer stem cells may nned to be eliminated in order to control the tumor. Thus one may define TCP as the probability of eliminating CSCs for the given dose of radiation. Methods: Using stochastic methods, specifically the birth-and-death Markov processes, an infinite system of equations is set for probabilities of having m cancer stem cells at time t after the start of radiation. The TCP is calculated as the probability of no cancer stem cells surviving the radiation. Two scenarios are studied. In the first situation, the TCP is calculated for a unidirectional case when CSC gives birth to another CSC or a progenitor cell. In the second scenario, a bidirectional model is studied where the progenitor cell gives rise to CSC. Results: The proposed calculations show that the calculated TCP for CSC depends on whether one adopts unidirectional or bidirectional conversion models. The bidirectional model shows significantly lower TCP values for the given dose delivered to the tumor. Conclusion: Incorporating CSC hypothesis into the TCP modeling may notably influence the dose prescription as well as the concept of the expected TCP after the radiation treatments.

  1. Non-radial radiative transfer in clese binaries. Application to the bolometric reflection effect in W UMa stars

    Pustylnik, I.

    1977-01-01

    In near-contact binary systems a significant portion of the total amount of the radiative energy is blocked between the facing hemispheres of two component stars. This circumstance combined with the lack of spherical symmetry of the radiation field may give rise to non-radial radiative transport. It is shown for a case of a spherical stellar atmosphere illuminated by a parallel beam of radiation that anisotropic scattering may be responsible for the non-radial component of the radiative flux. The effect of non-radial radiative transfer in close binaries would increase the total energy output observed at elongations at the expense of the radiative energy seen during conjunctions and would lead to colour changes qualitatively resembling those observed in many W UMa stars. Presumably it will be difficult to distinguish periodical light changes due to non-radial radiative transfer from those caused by distortions of the components or gravitational darkening. An order-of-magnitude estimate is made with the result that the bolometric amplitude of the non-radially scattered light probably does not exceed one per cent of the total luminosity of a binary system. (author)

  2. Processes give selection location like fundamental approach gives the security for the repositories radioactive waste (radioactive installation) in Cuba

    Peralta Vidal, J.L.; Gil Castillo, R.O.; Chales Suarez, G.; Rodriguez Reyes, A.

    1998-01-01

    On the base for the best international practice, the requirements given by the IAEA, specialized national experience, the technician economic conditions and social matters give Cuba, it has been documented in the country the process the documented location for evacuation and storage the worn-out fuel lingeringly

  3. Dose limits for ionising radiation

    Gifford, D.

    1989-01-01

    Dose limits for exposure to ionising radiation are assessed to see if they give sufficient protection both for the occupationally exposed and for the general public. It is concluded that current limits give a level of safety that satisfies the necessary criteria in the light of present knowledge and further reductions would be unlikely to improve standards of safety. (author)

  4. Statement about the situation of radiation research in Germany

    2002-01-01

    The Radiation Protection Association observes with profound concern the decline in radiation research in the Federal Republic of Germany. Among other consequences, this gives rise to the fear that Germany's influence on developments, decisions, and standards in international bodies is going to decline for lack of competence. Moreover, Germany will hardly be able to deal with the growing number of topical problems arising in radiation effects in cell biology and molecular biology. These aspects, and others, however, are going to be of overriding importance also in the future as by far most of the radiation exposure of persons is due to medical applications and is going to continue at least at the same level. It would therefore be desirable if the competent government agencies made available the necessary funds. A national coordinating agency yet to be established, which would be made up of representatives of the university and non-university institutions concerned, could define research goals and award research contracts within the framework of a research program. (orig.) [de

  5. Radiation monitoring systems and methodologies for radiological impact assessment

    Chaudhury, Probal

    2016-01-01

    Radioactive sources of various strengths are used in large number of applications in industry, healthcare, agriculture and research. Though all the sources are transported and used under regulatory control, there is always a possibility of some of the sources getting into the hands of committed antisocial non state actors. In addition to this, there is a possible threat of radioactive material being illegally brought into a country. These gives rise to an increase in the global radiological threat and security experts world over are concerned about the possibility of malicious use of radiation in the public domain. Radiation detection systems are installed at various entry and exit ports of some of the countries to detect illicit trafficking of radioactive materials. IAEA has recommended that all States should have a national response plan for nuclear security events to provide for an appropriate and coordinated response. Considering the requirement of radiological emergency preparedness, various radiation monitoring systems and methodologies have been developed. A few aerial radiation monitoring systems developed at Bhabha Atomic Research Centre (BARC) for radiological impact assessment are described here

  6. World medical schools: The sum also rises.

    Rigby, Perry G; Gururaja, Ramnarayan P

    2017-06-01

    There is a worldwide shortage of doctors, which is true in most countries and on most continents. To enumerate the number of medical schools in the world at two different times, showing the trends and relating this to population is a beginning. The number is actually going up and has done so for some time; this has increased the supply of physicians and broadened healthcare delivery. The number to count for geographic and regional information about the medical schools relates directly to the supply of doctors. Regions were chosen from WHO and Foundation for the Advancement of International Medical Education and Research data to illustrate geographic distributions, physicians per patient and kinetics. The number of medical schools has consistently been rising around the world. However, world order is reverting to disorder, considering wars, disease and beleaguered stand-offs. None. Eight countries contain 40% of medical schools; however, several locations are rising faster than the rest. Some regions are stable, but sub-Saharan Africa, the Caribbean, South Asia and South America have increased the most in percentage recently, but not uniformly. Medical schools are related not only by geography, political boundaries and population but are concentrated in some regions. Graduate Medical Education positions appear to be short on a worldwide basis, as well as in some regions and countries. The number of medical schools is increasing worldwide and the identification of rapidly rising geographic areas is useful in exploring, planning and comparing regions. Controversy continues in a variety of locations, especially concerning Graduate Medical Education. In addition to funding, faculty candidates and accreditation, new schools are confronting a variety of choices in standards and quality, sizing and regional concerns.

  7. A Childhood Rich in Culture Gives a Socioeconomic Bonus

    Austring, Bennye Düranc

    2015-01-01

    Artiklen ridser den nyeste forskning op inden for feltet 'art rich learning', altså æstetiske læreprocesser af god kvalitet. In the book ”Art and Culture Give Children a Life that Works” 60 (Danish and non-Danish) experts, practitioners, artists and several Ministers from the Danish Government fo...... focus on the significance of Art and Culture for children. The book provides lots of inspiration for teachers, pedagogues and cultural mediators and contains many examples of specific cultural activities, links and bibliographic references.......Artiklen ridser den nyeste forskning op inden for feltet 'art rich learning', altså æstetiske læreprocesser af god kvalitet. In the book ”Art and Culture Give Children a Life that Works” 60 (Danish and non-Danish) experts, practitioners, artists and several Ministers from the Danish Government...

  8. Framing charitable donations as exceptional expenses increases giving.

    Sussman, Abigail B; Sharma, Eesha; Alter, Adam L

    2015-06-01

    Many articles have examined the psychological drivers of charitable giving, but little is known about how people mentally budget for charitable gifts. The present research aims to address this gap by investigating how perceptions of donations as exceptional (uncommon and infrequent) rather than ordinary (common and frequent) expenses might affect budgeting for and giving to charity. We provide the first demonstration that exceptional framing of an identical item can directly influence mental budgeting processes, and yield societal benefits. In 5 lab and field experiments, exceptional framing increased charitable behavior, and diminished the extent to which people considered the effect of the donation on their budgets. The current work extends our understanding of mental accounting and budgeting for charitable gifts, and demonstrates practical techniques that enable fundraisers to enhance the perceived exceptionality of donations. (c) 2015 APA, all rights reserved).

  9. Effect of radiation damping on the interaction of ultra-intense laser pulses with an overdense plasma

    Zhidkov, Alexei; Koga, James; Sasaki, Akira; Ueshima, Yutaka

    2001-01-01

    The effect of radiation damping on the interaction of an ultra-intense laser pulse with an overdense plasma is studied via relativistic particle-in-cell simulation. The calculation is performed for a Cu solid slab including ionization. We find a strong effect from radiation damping on the electron energy cut-off at about 150 MeV and on the absorption of a laser pulse with an intensity I=5x10 22 W/cm 2 and duration of 20 fs. Hot electrons reradiate more then 10% of the laser energy during the laser pulse. With the laser intensity, the energy loss due to the radiation damping increases as I 3 . In addition, we observe that the laser pulse may not propagate in the plasma even if ω pl 2 /ω 2 γ<1. The increase of skin depth with the laser intensity due to relativistic effects gives rise to the absorption efficiency. (author)

  10. Protective Effect of Curcumin against Ionizing Radiation (IR)-induced Cytotoxicity and Genotoxicity in HepG2 Cells

    Chung, Dong Min; Nasir Uddin, S. M.; Ryu, Tae Ho; Kang, Mi Young; Kim, Jin Kyu

    2013-01-01

    Ionizing radiation (IR) has many practical applications such as medicine, foods, agricultures, industries, and research laboratories. However, the increasing use of radiation is associated with radiation accidents threatening human health. It is well known that exposure to IR gives rise to genomic alterations, mutagenesis, and cell death. IR is absorbed directly by DNA, leading to various DNA damages (single or double-strand breaks, base damage, and DNA-DNA or DNA-protein cross-linkages) in many living organisms. Therefore, the development of effective and nontoxic radioprotective agents is of considerable interest. Curcumin (C 12 H 20 O 6 , structure is the major yellow component of Curcuma longa with biological activities (antioxidant, anti-proliferative and anti-inflammatory properties). It has been widely used as food and medicine for a long time. The aim of our present study is to investigate the protective effects of curcumin against IR-induced cytotoxicity and genotoxicity in cultured HepG2 cells

  11. The economic consequences of rising oil prices

    Lescaroux, F.

    2006-05-01

    In the context of rising crude oil prices observed in the last five years, this paper attempts to shed light on the possible consequences of a costlier barrel. We shall begin with a brief presentation of the main results of the analyses conducted in the last 30 years, concerning the impact of energy prices on economic activity. We shall then interpret these analyses and their conclusions, and try to draw a number of lessons about the anticipated effects of the recent trend in energy prices. (author)

  12. Sea level rise in the Arctic Ocean

    Proshutinsky, Andrey; Pavlov, Vladimir; Bourke, Robert H.

    2001-01-01

    The article of record as published may be found at http://dx.doi.org/10.1029/2000GL012760 About 60 tide-gauge stations in the Kara, Laptev, East-Siberian and Chukchi Seas have recorded the sea level change from the 1950s through 1990s. Over this 40-year period, most of these stations show a significant sea level rise (SLR). In light of global change, this SLR could be a manifestation of warming in the Artic coupled with a decrease of sea ice extent, warming of Atlantic waters, changes in...

  13. The rise and fall of the ridge

    Sorensen, Paul [Brookhaven National Laboratory, Upton, NY 11973 (United States)

    2011-04-01

    Recent data from heavy ion collisions at RHIC show unexpectedly large near-angle correlations that broaden longitudinally with centrality. The amplitude of this ridge-like correlation rises rapidly with centrality, reaches a maximum, and then falls in the most central collisions. In this talk we explain how this behavior can be easily understood in a picture where final momentum-space correlations are driven by initial coordinate space density fluctuations. We propose {nu}{sub n}{sup 2}/{epsilon}{sub n,part}{sup 2} as a useful way to study these effects and explain what it tells us about the collision dynamics.

  14. Consumerism and wellness: rising tide, falling cost.

    Domaszewicz, Alexander

    2008-01-01

    Annual employer-sponsored health plan cost increases have been slowing incrementally due to slowing health care utilization--a phenomenon very likely tied to the proliferation of health management activities, wellness programs and other consumerism strategies. This article describes the sharp rise in recent years of consumer-directed health plans (CDHPs) and explains what developments must happen for genuine consumer-directed health care to realize its full potential. These developments include gathering transparent health care information, increasing consumer demand for that information and creating truly intuitive data solutions that allow consumers to easily access information in order to make better health care decisions.

  15. Hydrodynamics in a swarm of rising bubbles

    Riboux, G.

    2007-04-01

    In many applications, bubbles are used to agitate a liquid in order to enhance mixing and transfer. This work is devoted to the study of the hydrodynamics in a stable bubble column. Experimentally, we have determined the properties of the velocity fluctuations inside and behind a homogeneous swarm of rising bubbles for different bubble sizes and gas volume fractions α: self-similarity in α 0,4 , spectrum in k -3 and integral length scale controlled by buoyancy. Numerically, we have reproduced these properties by means of large-scale simulations, the bubbles being modeled by volume-forces. This confirms that the dynamics is controlled by wake interactions. (author)

  16. The rising home birth trend in America

    Nurlan Aliyev; Chastidy Roldan; Bulent Cakmak

    2015-01-01

    In recent years home birth rates are increased in the whole world, mainly in the United States (US). Between 2004-2012, non-hospital births increasing rate is 89% in the US. Home birth increased especially among the married, non-Hispanic, over 35 years of age, multipar and singleton pregnancies. However the high rate of cesarean birth did not increase in recent years in the US, now it has been stable at 32%. It is reported that the stability of the cesarean rate is related to rising rate of h...

  17. Nuclear costs: why do they keep rising?

    MacKerron, Gordon

    1992-01-01

    Nuclear power has performed badly in recent years as a new investment everywhere except Japan and Korea. This has mainly been for orthodox financial and economic reasons. Among the factors contributing to this loss of competitiveness, persistently rising real capital costs have been particularly important. While the nuclear industry has believed it could control and reduce capital costs, increasing regulatory stringency has made designs more complex and correspondingly more costly. These cost increasing factors have far outweighed traditional cost reducing factors (like learning). The only lasting way to meet increasing stringency in safety at acceptably low cost is likely to be the development of new and simpler reactor designs. (author)

  18. Low-rise shear wall failure modes

    Farrar, C.R.; Hashimoto, P.S.; Reed, J.W.

    1991-01-01

    A summary of the data that are available concerning the structural response of low-rise shear walls is presented. This data will be used to address two failure modes associated with the shear wall structures. First, data concerning the seismic capacity of the shear walls with emphasis on excessive deformations that can cause equipment failure are examined. Second, data concerning the dynamic properties of shear walls (stiffness and damping) that are necessary to compute the seismic inputs to attached equipment are summarized. This case addresses the failure of equipment when the structure remains functional. 23 refs

  19. Self gift Giving: A New Widespread Consumption Culture

    KAR, Yrd.Doç.Dr. Altan

    2013-01-01

    SUMMARY The meanings derived from consumption goods have an increasing impact on the psychological formation of individuals Hence to understand the complex nature of consumer behavior a multidisciplinary approach is needed Consumption goods become magical fetish objects which satisfy individual pleasures The gift in this concept becomes a token that the individual gives her himself and evolves from being a collective system to an individual form of consumption The aim of this study...

  20. Laser techniques for radioactive decontamination gives metallic surfaces

    Escobar Alracon, L.; Molina, G.; Vizuet Gonzalez, J.

    1998-01-01

    In this work it presented the prototype for system decontamination at diverse component with removable superficial contamination, using the technique gives laser ablation, for the evaporation at the pollutant. It discusses the principle in the fact that system, as well as the different elements that compose it. The are presented the obtained results when irradiating with a laser a surface without radioactive contamination to verify the system operation

  1. Giving an account of one's pain in the anthropological interview.

    Buchbinder, Mara

    2010-03-01

    In this paper, I analyze the illness stories narrated by a mother and her 13-year-old son as part of an ethnographic study of child chronic pain sufferers and their families. In examining some of the moral, relational and communicative challenges of giving an account of one's pain, I focus on what is left out of some accounts of illness and suffering and explore some possible reasons for these elisions. Drawing on recent work by Judith Butler (Giving an Account of Oneself, 2005), I investigate how the pragmatic context of interviews can introduce a form of symbolic violence to narrative accounts. Specifically, I use the term "genre of complaint" to highlight how anthropological research interviews in biomedical settings invoke certain typified forms of suffering that call for the rectification of perceived injustices. Interview narratives articulated in the genre of complaint privilege specific types of pain and suffering and cast others into the background. Giving an account of one's pain is thus a strategic and selective process, creating interruptions and silences as much as moments of clarity. Therefore, I argue that medical anthropologists ought to attend more closely to the institutional structures and relations that shape the production of illness narratives in interview encounters.

  2. X-ray polarimetry with a conventional gas proportional counter through rise-time analysis

    Hayashida, K; Tsunemi, H; Torii, K; Murakami, H; Ohno, Y; Tamura, K

    1999-01-01

    We have performed an experiment on the signal rise time of a Xe gas proportional counter using a polarized X-ray beam of synchrotron orbital radiation with energies from 10 to 40 keV. When the counter anode is perpendicular to the electric vector of the incident X-ray photons, the average rise time becomes significantly longer than that for the parallel case. This indicates that the conventional gas proportional counters are useful for X-ray polarimetry. The moderate modulation contrast of this rise-time polarimeter (M=0.1 for 10 keV X-rays and M=0.35 for 40 keV X-rays), with capability of the simultaneous measuring X-ray energies and the timing, would be useful for applications in X-ray astronomy and in other fields.

  3. Non-cultured adipose-derived CD45(-) side population cells are enriched for progenitors that give rise to myofibres in vivo

    Andersen, Ditte C; Schrøder, Henrik D; Jensen, Charlotte H

    2008-01-01

    Side population (SP) cells are highly able to exclude the Hoechst 33342 dye through membrane transporters, a feature associated with cell immaturity and therefore proposed as a marker of stem cells. Herein we demonstrate that the adipose tissue derived stromal vascular fraction (SVF) contains...... skeletal muscle repair mainly relies on the satellitecell, several reports have shown that vessel-associated cells may adopt a myogenic phenotype when exposed to a muscle environment. In accordance with these findings, we also observed invitro myogenic specification of SPCD45(-) cells when cocultured...... a novel population of non-haematopoietic "side population" (SPCD45(-)) cells. Simultaneous qRT-PCR of 64 genes revealed that the freshly isolated SPCD45(-) was highly enriched for cells expressing genes related to stem cells, the Notch pathway, and early vascular precursors. Notably, the expression...

  4. Network models predict that reduced excitatory fluctuations can give rise to hippocampal network hyper-excitability in MeCP2-null mice.

    Ernest C Y Ho

    Full Text Available Rett syndrome is a severe pediatric neurological disorder caused by loss of function mutations within the gene encoding methyl CpG-binding protein 2 (MeCP2. Although MeCP2 is expressed near ubiquitously, the primary pathophysiology of Rett syndrome stems from impairments of nervous system function. One alteration within different regions of the MeCP2-deficient brain is the presence of hyper-excitable network responses. In the hippocampus, such responses exist despite there being an overall decrease in spontaneous excitatory drive within the network. In this study, we generated and used mathematical, neuronal network models to resolve this apparent paradox. We did this by taking advantage of previous mathematical modelling insights that indicated that decreased excitatory fluctuations, but not mean excitatory drive, more critically explain observed changes in hippocampal network oscillations from MeCP2-null mouse slices. Importantly, reduced excitatory fluctuations could also bring about hyper-excitable responses in our network models. Therefore, these results indicate that diminished excitatory fluctuations may be responsible for the hyper-excitable state of MeCP2-deficient hippocampal circuitry.

  5. Imparting improvements in electrochemical sensors: evaluation of different carbon blacks that give rise to significant improvement in the performance of electroanalytical sensing platforms

    Vicentini, Fernando Campanhã; Ravanini, Amanda E.; Figueiredo-Filho, Luiz C.S.; Iniesta, Jesús; Banks, Craig E.; Fatibello-Filho, Orlando

    2015-01-01

    Three different carbon black materials have been evaluated as a potential modifier, however, only one demonstrated an improvement in the electrochemical properties. The carbon black structures were characterised with SEM, XPS and Raman spectroscopy and found to be very similar to that of amorphous graphitic materials. The modifications utilised were constructed by three different strategies (using ultrapure water, chitosan and dihexadecylphosphate). The fabricated sensors are electrochemically characterised using N,N,N',N'-tetramethyl-para-phenylenediamine and both inner-sphere and outer-sphere redox probes, namely potassium ferrocyanide(II) and hexaammineruthenium(III) chloride, in addition to the biologically relevant and electroactive analytes, dopamine (DA) and acetaminophen (AP). Comparisons are made with an edge-plane pyrolytic graphite and glassy-carbon electrode and the benefits of carbon black implemented as a modifier for sensors within electrochemistry are explored, as well as the characterisation of their electroanalytical performances. We reveal significant improvements in the electrochemical performance (excellent sensitivity, faster heterogeneous electron transfer rate (HET)) over that of a bare glassy-carbon and edge-plane pyrolytic graphite electrode and thus suggest that there are substantial advantages of using carbon black as modifier in the fabrication of electrochemical based sensors. Such work is highly important and informative for those working in the field of electroanalysis where electrochemistry can provide portable, rapid, reliable and accurate sensing protocols (bringing the laboratory into the field), with particular relevance to those searching for new electrode materials

  6. Characteristics of the polar cap at ionospheric levels and present understanding of the physical processes that give rise to these characteristics

    Brekke, A.

    1983-01-01

    This chapter discusses the relationship between the interplanetary magnetic field (IMF) and various polar cap current systems, such as the DP2-system and the S /SUB q/ P-system. The disagreements concerning these systems are examined. Topics considered include the polar cap (a result of an open magnetosphere); studies of the polar cap magnetic field variations; the DP2-current system and its relation to the IMF; the polar cap current system during a northward IMF; the azimuthal component of IMF and its influence on the polar cap magnetic field variations; the electric potential distribution on the polar cap; rocket observations of the polar cap electric field; the auroral arcs as a visible trace of the ionospheric convection; neutral wind measurements in the polar cap F-region; and further studies of polar cap dynamics. The focus is on the polar region inside the auroral oval. It is suggested that more research is needed of the polar cap current system in order to understand the magnetosphereionosphere coupling, with the polar cap ionospheric conductivity distribution being the most crucial parameter

  7. Classification of real Lie superalgebras based on a simple Lie algebra, giving rise to interesting examples involving {mathfrak {su}}(2,2)

    Guzzo, H.; Hernández, I.; Sánchez-Valenzuela, O. A.

    2014-09-01

    Finite dimensional semisimple real Lie superalgebras are described via finite dimensional semisimple complex Lie superalgebras. As an application of these results, finite dimensional real Lie superalgebras mathfrak {m}=mathfrak {m}_0 oplus mathfrak {m}_1 for which mathfrak {m}_0 is a simple Lie algebra are classified up to isomorphism.

  8. Acute disseminated melioidosis giving rise to pneumonia and renal abscesses complicated with thrombotic thrombocytopenic purpura in a post partum woman: a case report.

    Wijewickrama, Piyumi Sachindra Alwis; Weerakoon, Rohini

    2017-11-29

    Melioidosis is an established endemic infection in Sri Lanka, caused by Burkholderia pseudomallei, a gram negative bacterium distributed in saprophytes in soil and surface water. Main mode of transmission is via percutaneous inoculation. Pneumonia is the most common presentation in acute disease. We report a 33 year old previously healthy Sinhalese female with an occupational exposure to surface water in paddy fields, who was on postpartum day 6 following an uncomplicated pregnancy and delivery via an elective caesarian section. She presented with a 1 day history of breathlessness, preceded by a brief episode of fever. She had occasional right side coarse crackles and pitting oedema of both lower limbs. Shortly after admission, she developed type one respiratory failure needing invasive mechanical ventilation. Initial chest x-ray revealed slight obliteration of right medial diaphragmatic border while echocardiogram revealed moderate pulmonary hypertension. Computed tomography pulmonary angiogram excluded a pulmonary embolism, but revealed bilateral multi-lobar consolidation. Abdominal computed tomography demonstrated bilateral pyelonephritis with renal abscesses. As initial cultures were inconclusive, melioidosis antibody levels were done due to high degree of suspicion, which was found to be positive with a titer of 1:2560. A diagnosis of melioidosis was made based on the suggestive clinical picture, exposure history and the highly positive antibody level. She developed left side focal seizures together with thrombocytopenia and microangiopathic haemolytic anemia, suggestive of thrombotic thrombocytopenic purpura. Magnetic resonance imaging of brain was negative for cerebral abscesses but revealed extensive minute haemorrhagic foci throughout the cerebrum. Thus, the final diagnosis was acute melioidosis causing pneumonia and renal abscesses, complicated with thrombotic thrombocytopenic purpura and sepsis. She demonstrated dramatic response to high dose meropenem and co-trimoxazole along with plasmapheresis. Four weeks after treatment, the antibody titer came down to 1:320. Melioidosis antibody was absent in the baby. This case was challenging as it was an atypical presentation of melioidosis during postpartum leading to a diagnostic conundrum. This highlights the need to look into the effect of pregnancy and postpartum as added risk factors. High index of suspicion is necessary to avoid diagnostic delays.

  9. Nitrosylation of Nitric-Oxide-Sensing Regulatory Proteins Containing [4Fe-4S] Clusters Gives Rise to Multiple Iron-Nitrosyl Complexes

    Serrano, Pauline N. [Department of Chemistry, University of California, Davis CA 95616 USA; Wang, Hongxin [Department of Chemistry, University of California, Davis CA 95616 USA; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA 94720 USA; Crack, Jason C. [Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich Research Park Norwich NR4 7TJ UK; Prior, Christopher [Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich Research Park Norwich NR4 7TJ UK; Hutchings, Matthew I. [School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ UK; Thomson, Andrew J. [Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich Research Park Norwich NR4 7TJ UK; Kamali, Saeed [University of Tennessee Space Institute, Tullahome TN 37388-9700 USA; Yoda, Yoshitaka [Research and Utilization Division, SPring-8/JASRI, 1-1-1 Kouto, Sayo Hyogo 679-5198 Japan; Zhao, Jiyong [Advanced Photon Source, Argonne National Laboratory, Argonne IL 60439 USA; Hu, Michael Y. [Advanced Photon Source, Argonne National Laboratory, Argonne IL 60439 USA; Alp, Ercan E. [Advanced Photon Source, Argonne National Laboratory, Argonne IL 60439 USA; Oganesyan, Vasily S. [Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich Research Park Norwich NR4 7TJ UK; Le Brun, Nick E. [Centre for Molecular and Structural Biochemistry, School of Chemistry, University of East Anglia, Norwich Research Park Norwich NR4 7TJ UK; Cramer, Stephen P. [Department of Chemistry, University of California, Davis CA 95616 USA; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley CA 94720 USA

    2016-10-25

    The reaction of protein-bound iron–sulfur (Fe-S) clusters with nitric oxide (NO) plays key roles in NO-mediated toxicity and signaling. Elucidation of the mechanism of the reaction of NO with DNA regulatory proteins that contain Fe-S clusters has been hampered by a lack of information about the nature of the iron-nitrosyl products formed. Herein, we report nuclear resonance vibrational spectroscopy (NRVS) and density functional theory (DFT) calculations that identify NO reaction products in WhiD and NsrR, regulatory proteins that use a [4Fe-4S] cluster to sense NO. This work reveals that nitrosylation yields multiple products structurally related to Roussin's Red Ester (RRE, [Fe2(NO)4(Cys)2]) and Roussin's Black Salt (RBS, [Fe4(NO)7S3]. In the latter case, the absence of 32S/34S shifts in the Fe-S region of the NRVS spectra suggest that a new species, Roussin's Black Ester (RBE), may be formed, in which one or more of the sulfide ligands is replaced by Cys thiolates.

  10. Invasive salivary duct carcinoma ex pleomorphic adenoma of the parotid gland: a teaching case giving rise to the genuine diagnostic difficulty on an inadequate cytology specimen

    Yamada Sohsuke

    2012-05-01

    Full Text Available Abstract A history of a recent rapid increase in long-standing swelling mass was presented in the right parotid gland of an 85-year-old male. The inadequate cytologic specimens contained few small clusters of three-dimensional malignant epithelial cells having hyperchromatic pleomorphic nuclei and prominent nucleoli, adjacent to a cluster of benign monomorphic myoepithelial cells. We first interpreted it merely as an adenocarcinoma, not otherwise specified. A radical parotidectomy was performed, and gross examination revealed an encapsulated and firm tumor lesion, looking grayish-blue to yellowish-white, focally associated with extracapsular invasion. On microscopic examination, the tumor was predominantly composed of a proliferation of highly atypical epithelial cells having abundant eosinophilic cytoplasm, often arranged in a Roman-bridge appearance with foci of comedo necrosis, alternating with extensive infiltration to adjacent stroma in a trabecular or alveolar fashion with severe vessel permeation. Within the background of pleomorphic adenoma, the carcinoma cells sometimes replaced ductal luminal cells while retaining an intact-like myoepithelial layer. Therefore, we finally made a diagnosis of invasive salivary duct carcinoma ex pleomorphic adenoma. We should be aware that owing to its characteristic features, cytopathologists might be able to determine correct diagnosis, based on multiple and adequate samplings. Virtual slides The virtual slide(s for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2126158270695815

  11. Vascular wall-resident CD44+ multipotent stem cells give rise to pericytes and smooth muscle cells and contribute to new vessel maturation.

    Diana Klein

    Full Text Available Here, we identify CD44(+CD90(+CD73(+CD34(-CD45(- cells within the adult human arterial adventitia with properties of multipotency which were named vascular wall-resident multipotent stem cells (VW-MPSCs. VW-MPSCs exhibit typical mesenchymal stem cell characteristics including cell surface markers in immunostaining and flow cytometric analyses, and differentiation into adipocytes, chondrocytes and osteocytes under culture conditions. Particularly, TGFß1 stimulation up-regulates smooth muscle cell markers in VW-MPSCs. Using fluorescent cell labelling and co-localisation studies we show that VW-MPSCs differentiate to pericytes/smooth muscle cells which cover the wall of newly formed endothelial capillary-like structures in vitro. Co-implantation of EGFP-labelled VW-MPSCs and human umbilical vein endothelial cells into SCID mice subcutaneously via Matrigel results in new vessels formation which were covered by pericyte- or smooth muscle-like cells generated from implanted VW-MPSCs. Our results suggest that VW-MPSCs are of relevance for vascular morphogenesis, repair and self-renewal of vascular wall cells and for local capacity of neovascularization in disease processes.

  12. Registry-based randomized controlled trials merged the strength of randomized controlled trails and observational studies and give rise to more pragmatic trials.

    Mathes, Tim; Buehn, Stefanie; Prengel, Peggy; Pieper, Dawid

    2018-01-01

    The objective of this study was to analyze the features of registry-based randomized trials (rRCTs). We systematically searched PubMed for rRCTs. Study selection was performed independently by two reviewers. We extracted all data in standardized tables and prepared descriptive summary statistics. The search resulted in 1,202 hits. We included 71 rRCTs. Most rRCTs were from Denmark and Sweden. Chronic conditions were considered in 82.2%. A preventive intervention was examined in 45.1%. The median of included patients was 2,000 (range: 69-246,079). Definition of the study population was mostly broad. Study procedures were regularly little standardized. The number of included and analyzed patients was the same in 82.1%. In half of the rRCTs, more than one registry was utilized. Various linkage techniques were used. In median, two outcomes were collected from the registry/ies. The median follow-up of the rRCTs was 5.3 years (range: 6 weeks to 27 years). Information on quality of registry data was reported in 11.3%. rRCTs can provide valid (randomization, low lost-to-follow-up rates, generalizable) patient important long-term comparative-effectiveness data for relative little effort. Researchers planning an RCT should always check whether existing registries can be used for data collection. Reporting on data quality must be improved for use in evidence synthesis. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Effects of drive current rise-time and initial load density distribution on Z-pinch characteristics

    Duan Yao-Yong; Guo Yong-Hui; Wang Wen-Sheng; Qiu Ai-Ci

    2005-01-01

    A two-dimensional, three-temperature radiation magneto-hydrodynamics model is applied to the investigation of evolutional trends in x-ray radiation power, energy, peak plasma temperature and density as functions of drive current rise-time and initial load density distribution by using the typical experimental parameters of tungsten wire-array Z-pinch on the Qiangguang-Ⅰ generator. The numerical results show that as the drive current rise-time is shortened, x-ray radiation peak power, energy, peak plasma density and peak ion temperature increase approximately linearly, but among them the x-ray radiation peak power increases more quickly. As the initial plasma density distribution in the radial direction becomes gradually flattened, the peak radiation power and the peak ion-temperature almost exponentially increase, while the radiation energy and the peak plasma density change only a little. The main effect of shortening drive current rise-time is to enhance compression of plasma, and the effect of flattening initial load density distribution in the radial direction is to raise the plasma temperature. Both of the approaches elevate the x-ray peak radiation power.

  14. Radiation Protection Dosimetry

    Kramer, H.M.; Schnuer, K.

    1992-01-01

    The contributions presented during the seminar provided clear evidence that radiation protection of the patient plays an increasingly important role for manufacturers of radiological equipment and for regulatory bodies, as well as for radiologists, doctors and assistants. The proceedings of this seminar reflect the activities and work in the field of radiation protection of the patient and initiate further action in order to harmonize dosimetric measurements and calculations, to ameliorate education and training, to improve the technical standards of the equipment and to give a push to a more effective use of ionising radiation in the medical sector

  15. Solved? The reductive radiation chemistry of alanine.

    Pauwels, Ewald; De Cooman, Hendrik; Waroquier, Michel; Hole, Eli O; Sagstuen, Einar

    2014-02-14

    The structural changes throughout the entire reductive radiation-induced pathway of l-α-alanine are solved on an atomistic level with the aid of periodic DFT and nudged elastic band (NEB) simulations. This yields unprecedented information on the conformational changes taking place, including the protonation state of the carboxyl group in the "unstable" and "stable" alanine radicals and the internal transformation converting these two radical variants at temperatures above 220 K. The structures of all stable radicals were verified by calculating EPR properties and comparing those with experimental data. The variation of the energy throughout the full radiochemical process provides crucial insight into the reason why these structural changes and rearrangements occur. Starting from electron capture, the excess electron quickly localizes on the carbon of a carboxyl group, which pyramidalizes and receives a proton from the amino group of a neighboring alanine molecule, forming a first stable radical species (up to 150 K). In the temperature interval 150-220 K, this radical deaminates and deprotonates at the carboxyl group, the detached amino group undergoes inversion and its methyl group sustains an internal rotation. This yields the so-called "unstable alanine radical". Above 220 K, triggered by the attachment of an additional proton on the detached amino group, the radical then undergoes an internal rotation in the reverse direction, giving rise to the "stable alanine radical", which is the final stage in the reductive radiation-induced decay of alanine.

  16. Radiation induced color in topaz crystals

    Castagnet, A.C.; Rocca, H.C.C.; Rostilato, M.E.C.M.

    1989-08-01

    The presence of defects and impurities in the crystal lattice alters the eletric field distribution within the crystal, allowing the electrons to occupy energy levels in the forbbiden band. Ionizing radiation supply the required energy to permit the electrons originaly bound to lattice atoms, to occupy effectively those intermediate levels, forming color centers. Dependig upon the nature and energy of the radiation, it is possible to produce defects in regions of the crystal, generating color centers. Based on these premises, a technique to induce color in originally colorless topaz, by using the IEA-R1 nuclear reactor, was developed at Engineering and Industrial Application Department (TE). Samples were irradiated inside iron capsules coated with cadmium foils. The iron, and principaly the cadmium, absorb the thermal neutrons that could activate crystal impurities generating long-lived radioisotopes. The epithermal neutrons that overpass the iron and cadmium barriers interact with the crystal atoms, causing lattice defects which give rise to color center, by subsequent ionization processes. The procedure used at TE induces permanent blue color, in natural colorless topaz. (author) [pt

  17. Gas-rise velocities during kicks

    White, D.B. (Sedco Forex (FR))

    1991-12-01

    This paper reports on experiments to examine gas migration rates in drilling muds that were performed in a 15-m-long, 200-mm-ID inclinable flow loop where air injection simulates gas entry during a kick. These tests were conducted using a xanthum gum (a common polymer used in drilling fluids) solution to simulate drilling muds as the liquid phase and air as the gas phase. This work represents a significant extension of existing correlations for gas/liquid flows in large pipe diameters with non- Newtonian fluids. Bubbles rise faster in drilling muds than in water despite the increased viscosity. This surprising result is caused by the change in the flow regime, with large slug-type bubbles forming at lower void fractions. The gas velocity is independent of void fraction, thus simplifying flow modeling. Results show that a gas influx will rise faster in a well than previously believed. This has major implications for kick simulation, with gas arriving at the surface earlier than would be expected and the gas outflow rate being higher than would have been predicted. A model of the two-phase gas flow in drilling mud, including the results of this work, has been incorporated into the joint Schlumberger Cambridge Research (SCR)/BP Intl. kick model.

  18. Rising synchrony controls western North American ecosystems

    Black, Bryan A.; van der Sleen, Peter; Di Lorenzo, Emanuele; Griffin, Daniel; Sydeman, William J.; Dunham, Jason B.; Rykaczewski, Ryan R.; Garcia-Reyes, Marisol; Safeeq, Mohammad; Arismendi, Ivan; Bograd, Steven J.

    2018-01-01

    Along the western margin of North America, the winter expression of the North Pacific High (NPH) strongly influences interannual variability in coastal upwelling, storm track position, precipitation, and river discharge. Coherence among these factors induces covariance among physical and biological processes across adjacent marine and terrestrial ecosystems. Here, we show that over the past century the degree and spatial extent of this covariance (synchrony) has substantially increased, and is coincident with rising variance in the winter NPH. Furthermore, centuries‐long blue oak (Quercus douglasii) growth chronologies sensitive to the winter NPH provide robust evidence that modern levels of synchrony are among the highest observed in the context of the last 250 years. These trends may ultimately be linked to changing impacts of the El Niño Southern Oscillation on mid‐latitude ecosystems of North America. Such a rise in synchrony may destabilize ecosystems, expose populations to higher risks of extinction, and is thus a concern given the broad biological relevance of winter climate to biological systems.

  19. Rising incidence of Merkel cell carcinoma

    Lyhne, Dorte; Lock-Andersen, Jørgen; Dahlstrøm, Karin

    2011-01-01

    Abstract Merkel cell carcinoma (MCC) is a rare, aggressive, skin cancer of obscure histogenesis, the incidence of which is rising. There is no consensus on the optimal treatment. Our aim was to evaluate the staging, investigation, treatment, and follow-up of MCC in eastern Denmark, and to investi......Abstract Merkel cell carcinoma (MCC) is a rare, aggressive, skin cancer of obscure histogenesis, the incidence of which is rising. There is no consensus on the optimal treatment. Our aim was to evaluate the staging, investigation, treatment, and follow-up of MCC in eastern Denmark......, and to investigate the incidence. We suggest guidelines for treatment. First we reviewed the medical records of 51 patients diagnosed with MCC from 1995 until 2006 in eastern Denmark. The nation-wide incidence of MCC was extracted from the Danish Cancer Registry for the calculations for the period 1986-2003. We...... reviwed published papers about MCC based on a MEDLINE search. Fourteen of the 51 patients developed recurrence, and 37 (73%) died during the study period. Mean follow-up was 13 months (range 1-122). A total of 153 patients were identified in the Danish Cancer Registry, and showed that incidence rates had...

  20. Colliding Epidemics and the Rise of Cryptococcosis

    Christina C. Chang

    2015-12-01

    Full Text Available Discovered more than 100 years ago as a human pathogen, the Cryptococcus neoformans–Cryptococcus gattii (C. neoformans–C. gattii complex has seen a large global resurgence in its association with clinical disease in the last 30 years. First isolated in fermenting peach juice, and identified as a human pathogen in 1894 in a patient with bone lesions, this environmental pathogen has now found niches in soil, trees, birds, and domestic pets. Cryptococcosis is well recognized as an opportunistic infection and was first noted to be associated with reticuloendothelial cancers in the 1950s. Since then, advances in transplant immunology, medical science and surgical techniques have led to increasing numbers of solid organ transplantations (SOT and hematological stem cell transplantations being performed, and the use of biological immunotherapeutics in increasingly high-risk and older individuals, have contributed to the further rise in cryptococcosis. Globally, however, the major driver for revivification of cryptococcosis is undoubtedly the HIV epidemic, particularly in Sub-Saharan Africa where access to care and antiretroviral therapy remains limited and advanced immunodeficiency, poverty and malnutrition remains the norm. As a zoonotic disease, environmental outbreaks of both human and animal cryptococcosis have been reported, possibly driven by climate change. This is best exemplified by the resurgence of C. gattii infection in Vancouver Island, Canada, and the Pacific Northwest of the United States since 1999. Here we describe how the colliding epidemics of HIV, transplantation and immunologics, climate change and migration have contributed to the rise of cryptococcosis.

  1. Radiation annealing in cuprous oxide

    Vajda, P.

    1966-01-01

    Experimental results from high-intensity gamma-irradiation of cuprous oxide are used to investigate the annealing of defects with increasing radiation dose. The results are analysed on the basis of the Balarin and Hauser (1965) statistical model of radiation annealing, giving a square...

  2. Interactive visual intervention planning in particle accelerator environments with ionizing radiation

    Fabry, Thomas

    2014-01-01

    radiation. Several industrial and scientific procedures give rise to facilities with ionizing radiation. Most technical and scientific facilities also need maintenance operations. In the spirit of ALARA, these interventions need to be optimized in terms of the exposure of the maintenance workers to ionizing radiation. This optimization cannot be automated since the feasibility of the intervention tasks requires human assessment. The intervention planning could however be facilitated by technical-scientific means, e.g. software tools. In the context sketched above, this thesis provides technical-scientific considerations and the development of technical-scientific methodologies and software tools for the implementation of radiation protection.In particular, this thesis addresses the need for an interactive visual intervention planning tool in the context of high energy particle accelerator facilities. (author)

  3. Radiation protection

    Koelzer, W.

    1975-01-01

    Physical and radiological terms, quantities, and units. Basic principles of radiation protection (ICRP, IAEA, EURATOM, FRG). Biological effects of ionizing radiation. Objectives of practical radiation protection. (HP) [de

  4. Biological Complexities in Radiation Carcinogenesis and Cancer Radiotherapy: Impact of New Biological Paradigms

    Hossein Mozdarani

    2012-01-01

    Full Text Available Although radiation carcinogenesis has been shown both experimentally and epidemiologically, the use of ionizing radiation is also one of the major modalities in cancer treatment. Various known cellular and molecular events are involved in carcinogenesis. Apart from the known phenomena, there could be implications for carcinogenesis and cancer prevention due to other biological processes such as the bystander effect, the abscopal effect, intrinsic radiosensitivity and radioadaptation. Bystander effects have consequences for mutation initiated cancer paradigms of radiation carcinogenesis, which provide the mechanistic justification for low-dose risk estimates. The abscopal effect is potentially important for tumor control and is mediated through cytokines and/or the immune system (mainly cell-mediated immunity. It results from loss of growth and stimulatory and/or immunosuppressive factors from the tumor. Intrinsic radiosensitivity is a feature of some cancer prone chromosomal breakage syndromes such as ataxia telangectiasia. Radiosensitivity is manifested as higher chromosomal aberrations and DNA repair impairment is now known as a good biomarker for breast cancer screening and prediction of prognosis. However, it is not yet known whether this effect is good or bad for those receiving radiation or radiomimetic agents for treatment. Radiation hormesis is another major concern for carcinogenesis. This process which protects cells from higher doses of radiation or radio mimic chemicals, may lead to the escape of cells from mitotic death or apoptosis and put cells with a lower amount of damage into the process of cancer induction. Therefore, any of these biological phenomena could have impact on another process giving rise to genome instability of cells which are not in the field of radiation but still receiving a lower amount of radiation. For prevention of radiation induced carcinogenesis or risk assessment as well as for successful radiation

  5. Minimizing and measuring lens dose when giving cranial irradiation

    Woo, S.Y.; Donaldson, S.S.; Heck, R.J.; Nielson, K.L.; Shostak, C.

    1989-01-01

    Three different techniques of administering cranial irradiation were used to determine the dose to the lens as measured in the Rando phantom. The techniques employed were as follows: (1) the central axis of the radiation beam was placed at the thickest portion of the cranium; (2) the central axis of the radiation beam was placed at the lateral orbital rim (bon canthus); (3) the central axis of the radiation beam was placed at the thickest portion of the cranium but with the beam angled 5deg posteriorly away from the eye. Thermal luminescent dosimeters (TLD) were placed in a phantom, at a point determined from a life-sized anatomical section of the plane through the midsection of the eye, to be at the location of the posterior capsule of the lens. In addition, TLDs were placed on the outer surface of the phantom head, directly lateral to the location determined to be where the lens would lie. With equally weighted lateral opposed beams, delivering a midplane dose of 200cGy, the TLDs at the point of the lens measured 21, 9.9 and 10.6% of the midplane doses from the three techniques respectively. TLDs placed directly lateral to the lens on the surface of the phantom head gave an approximation of the lens dose, particularly when techniques 2 and 3 were used. Isodose curve generated by a General Electric treatment planning computer gave lens doses similar to those of the phantom data for each of the three different radiotherapy techniques. Cranial irradiation should be carried out by either technique 2 or technique 3 to minimize radiation dose to the lens. (author). 11 refs.; 2 figs.; 3 tabs

  6. Development of a site specific environmental radiation assessment model for Youngkwang NPPs

    Chung, Yang Geun; Song, Myung Jae; Shon, Soon Hwan; Shin, Sang Woon; Lee, Gap Bock; Yang, Kyung Hwa [Korea Electric Power Research Institute, Taejon (Korea, Republic of); Kim, Seong Pyung; Kim, Jeong Kyu; Shin, Dae Yoon; Kim, Hyun Ku; Lee, Kyung Jin [Chosun University, Kwangju (Korea, Republic of)

    1996-12-31

    During the normal operation of nuclear power plants, a very small amount of radionuclide materials is released to the environment. The radionuclide releases to the environment may give rise to some additional radiation dose through a number of pathways. With a few exception, radionuclide transports are highly dependent on the environmental conditions such as topological features, atmospheric and oceanic conditions and socio-environmental characteristics, etc. The dose calculation in Korea are presently being performed using the models in US NRC Reg. Guide. However, these models which were originally released by the US NRC in 1977 are inadequate to deal with environmental movement of radionuclides in consideration of complex terrain, tidal condition of the Yellow Sea, and Youngkwang site specific conditions. KEPRI has developed the models to consider the site specific characteristics around Youngkwang NPPs, to give the realistic dose assessment, and to improve assurance and reliability in public dose calculation. (author). 41 figs., 70 refs.

  7. Effect of penetrating ionising radiation on the mechanical properties of pericardium

    Daar, Eman, E-mail: e.daar@surrey.ac.u [Department of Physics, University of Surrey, Guildford GU2 7XH (United Kingdom); Woods, E. [Royal Free Hampstead NHS Trust, Pond Street, Hampstead, London NW3 2QG (United Kingdom); Keddie, J.L. [Department of Physics, University of Surrey, Guildford GU2 7XH (United Kingdom); Nisbet, A. [Department of Physics, University of Surrey, Guildford GU2 7XH (United Kingdom); Royal Surrey County Hospital, Guildford (United Kingdom); Bradley, D.A. [Department of Physics, University of Surrey, Guildford GU2 7XH (United Kingdom)

    2010-07-21

    The pericardium is an anistropic composite material made up of collagen and elastin fibres embedded in an amorphous matrix mainly composed of proteoglycan and hyaluronan. The collagen fibres are arranged in layers, with different directions of alignment in each layer, giving rise to interesting mechanical properties of pericardium, including the ability to undergo large deformation during performance of regular physiological functions. The present study aims to investigate the effect of penetrating photon ionising radiation on bovine pericardium tissue, being part of a study of the effect of cardiac doses received in breast radiotherapy and the possibility that this can give rise to cardiovascular complications. Irradiation doses in the range 5-80 Gy were used. To characterise the various mechanical properties [elastic modulus, stress relaxation, ultimate tensile strength (UTS) and fracture] a uniaxial tensile test method was applied. The preliminary results reflect the wide inter-sample variations that are expected in dealing with tissues, with only a weak indication of increase in the UTS of the pericardium tissue with increase in radiation dose. Such an effect has also been observed by others, with reduction in UTS at doses of 80 Gy.

  8. Liquid-microjet synchrotron-radiation spectroscopy for biomolecules in water solution 1

    Ukai, Masatoshi; Shimada, Hiroyuki

    2012-01-01

    A new spectroscopic research of radiation induced damage on DNA and its constituent molecules is proposed, which is made possible using a liquid micro-jet technique for bio-solution under vacuum in combination with synchrotron-radiation aided site-selective excitation. We emphasize a view point of time-evolutional production and destruction of irregular chemical species characteristic of time domains after irradiation, which finally result in the alternative processes to give rise to a irreparable damage or to avoid it by a thermodynamical restoration. Up to now a method of spectroscopy to identify the initial molecular site of radiation interaction is almost completed. The former part of the proposal article is presented in this volume. We describe the objectives of the new spectroscopy for observing the early processes of direct radiation effect on DNA leading to damage induction using a site-selective synchrotron-radiation excitation to identify the initial site of radiation interaction. The present status of development is described by presenting the new results of the spectra of X-ray absorption near edge structure and ejected electron energy spectra for liquid water as examples. The forthcoming latter part of this article will discuss the conformational and electronic structure of nucleotides in water solution prior to time evolution. (author)

  9. MRO's HiRISE Education and Public Outreach during the Primary Science Phase

    Gulick, V. C.; Davatzes, A. K.; Deardorff, G.; Kanefsky, B.; Conrad, L. B.; HiRISE Team

    2008-12-01

    Looking back over one Mars year, we report on the accomplishments of the HiRISE EPO program during the primary science phase of MRO. A highlight has been our student image suggestion program, conducted in association with NASA Quest as HiRISE Image Challenges (http://quest.arc.nasa.gov/challenges/hirise/). During challenges, students, either individually or as part of a collaborative classroom or group, learn about Mars through our webcasts, web chats and our educational material. They use HiWeb, HiRISE's image suggestion facility, to submit image suggestions and include a short rationale for why their target is scientifically interesting. The HiRISE team gives priority to obtaining a sampling of these suggestions as quickly as possible so that the acquired images can be examined by the students. During the challenge, a special password-protected web site allows participants to view their returned images before they are released to the public (http://marsoweb.nas.nasa.gov/hirise/quest/). Students are encouraged to write captions for the returned images. Finished captions are then posted and highlighted on the HiRISE web site (http://hirise.lpl.arizona.edu) along with their class, teacher's name and the name of their school. Through these HiRISE challenges, students and teachers become virtual science team members, participating in the same process (selecting and justifying targets, analyzing and writing captions for acquired images), and using the same software tools as the HiRISE team. Such an experience is unique among planetary exploration EPO programs. To date, we have completed three HiRISE challenges and a fourth is currently ongoing. More than 200 image suggestions were submitted during the previous challenges and over 85 of these image requests have been acquired so far. Over 675 participants from 45 states and 42 countries have registered for the previous challenges. These participants represent over 8000 students in grades 2 through 14 and consist

  10. Soil Structure Interaction Effect on High Rise and Low Rise Buildings

    Divya Pathak; PAresh H. SHAH

    2000-01-01

    Effect of supporting soil on the response of structure has been analyzed in the present study. A low rise (G+ 5 storey) and a high rise (G+12 storey) building has been taken for the analysis. For both type of buildings, the response of building with and without consideration of soil structure interaction effect has been compared.Without interaction case is the case in which ends of the structure are assumed to be fixed while in interaction case, structure is assumed to be...

  11. Radiation treatment of benign diseases

    Reitan, J.B.; Flatby, J.; Backe, S.; Lundgren, L.

    1984-01-01

    The report deals with an estimation of the volume of radiation treatment of benign diseases in Norway and gives a survey of the subjective opinion of patients regarding the result of the treatment. Reported subjective recovery after radiation treatment seems to be at the same level as recovery without treatment. For an indication of the objective effect of radiation treatment of benign diseases, the subjective effect of this treatment has to be compared with objective findings

  12. FIRE EVACUATION FROM HIGH-RISE BUILDINGS

    Korol'chenko Aleksandr Yakovlevich

    2012-10-01

    Full Text Available The authors argue that no collapse of structures is likely in the event of a fire emergency in multistoried buildings, rather, other fire-related factors may endanger the lives of people inside high-rise buildings exposed to the fire emergency, including open fire, sparks, high ambient temperature, smoke and toxic combustion products, reduced concentration of oxygen, and combined influence of various factors. In case of fire, the temperature inside buildings reaches 1100 °С. It exceeds the temperature of the ambient air acceptable for humans by far (70 °С. The experiments demonstrate that combustion products contain hundreds of toxic chemical compounds. The most hazardous of them include carbon oxide, carbon dioxide, chloride and cyanic hydrogen, aldehydes and acrolein. The author provides the pattern of their influence on the human body. The smoke consists of unburned particles of carbon and aerosols. The size of particles fluctuates within 0.05-50 MMK. Smoke produces a physiological and psychological impact on human beings. It has been proven that dangerous fire factors emerge within the first five to ten minutes of the emergency situation. Evacuation is the principal method of safety assurance. However, the velocity of propagation of smoke and heat is so high that even if the fire prevention system is in operation, people may be blocked both on the floors that are exposed to the fire and those that escape its propagation. New evacuation and rescue methods are recommended by the author. Various ways and methods of use of life-saving facilities are also provided. Safe evacuation is feasible from buildings where the number of stories does not exceed 10- 12. During evacuation, high density human streams are formed inside buildings, therefore, the period of stay in a burning building is increased. The calculations have proven that a two-minute delay of evacuation converts into a safe evacuation of only 13-15% of people. Low reliability of

  13. Wind load effects on high rise buildings in Peninsular Malaysia

    Nizamani, Z.; Thang, K. C.; Haider, B.; Shariff, M.

    2018-04-01

    Wind is a randomly varying dynamic phenomenon composed of a multitude of eddies of varying sizes and rotational characteristics along a general stream of air moving relative to the ground. These eddies give wind its gustiness, creating fluctuation and results in a complex flow characteristics. The wind vector at any point can be regarded as the sum of mean wind vector and the fluctuation components. These components not only vary with height but also dependant on the approach terrain and topography. Prevailing wind exerts pressure onto the structural surfaces. The effects of wind pressure in the form of shear and bending moments are found to be a major problem in structural failure. This study aims to study the effects of wind load on a fifteen-storey high rise building using EN 1991-1-4 code and MS1553:2002. The simulation results showed that by increasing the wind speed, the storey resultant forces, namely storey shear and storey moment increases significantly. Furthermore, simulation results according to EN 1991-1-4 yield higher values compared to the simulation results according to MS1553:2002.

  14. Kinetics of radiation-induced precipitation at the alloy surface

    Lam, N. Q.; Nguyen, T.; Leaf, G. K.; Yip, S.

    1988-05-01

    Radiation-induced precipitation of a new phase at the surface of an alloy during irradiation at elevated temperatures was studied with the aid of a kinetic model of segregation. The preferential coupling of solute atoms with the defect fluxes gives rise to a strong solute enrichment at the surface, which, if surpassing the solute solubility limit, leads to the formation of a precipitate layer. The moving precipitate/matrix interface was accommodated by means of a mathematical scheme that transforms spatial coordinates into a reference frame in which the boundaries are immobile. Sample calculations were performed for precipitation of the γ'-Ni 3Si layer on Ni-Si alloys undergoing electron irradiation. The dependences of the precipitation kinetics on the defect-production rate, irradiation temperature, internal defect sink concentration and alloy composition were investigated systematically.

  15. Projections of tsunami inundation area coupled with impacts of sea level rise in Banda Aceh, Indonesia

    Tursina, Syamsidik, Kato, Shigeru

    2017-10-01

    In a long term, sea level rise is anticipated to give devastating effects on Banda Aceh, as one of the coastal cities in the northern tip of Sumatra. The growth of the population and buildings in the city has come to the stage where the coastal area is vulnerable to any coastal hazard. Some public facilities and settlements have been constructed and keep expanding in the future. According to TOPEX/POSEIDON satellite images, 7 mm/year the sea level has been risen between 1992 and 2015 in this area. It is estimated that in the next 100 years, there will be 700 mm additional sea level rise which will give a setback more over to a rather flat area around the coast. This research is aim at investigating the influence of sea level rise toward the tsunami inundation on the land area particularly the impacts on Banda Aceh city. Cornell Multigrid Coupled Tsunami Model (COMCOT) simulation numerically generated tsunami propagation. Topography and bathymetry data were collected from GEBCO and updated with the available nautical chart (DISHIDROS, JICA, and field measurements). Geological movement of the underwater fault was generated using Piatanesi and Lorito of 9.15 Mw 2004 multi-fault scenario. The inundation area produced by COMCOT revealed that the inundation area was expanded to several hundred meters from the shoreline. To investigate the impacts of tsunami wave on Banda Aceh, the inundation area were digitized and analyzed with Quantum GIS spatial tools. The Quantum GIS analyzed inundations area affected by the projected tsunami. It will give a new tsunami-prone coastal area map induced by sea level rise in 100 years.

  16. Exploring the unprecedented rise in Danish burglary

    Sorensen, David W.M.

    2012-01-01

    burglary increased so dramatically. This paper explores four sets of possible explanations for the increase, namely: Changes in public reporting, police recording and insurance practices; changes in population age, drug use and economic recession; increasing crime tourism; and impediments policing caused...... by the National Police Reform of 2007. While some or all of these factors may have contributed to the overall rise, none of them come close to explaining it on their own. This absence of evidence is especially interesting in light of widespread assumptions in the media and among some police about foreign burglary......-year period 2005-2010, plus data on long term crime trends (1990-2010) and other social indicators....

  17. Is the Kingdom of Bicycles Rising Again?

    Rømer Christensen, Hilda

    2017-01-01

    This article focuses on new types of cycling in postsocialist China, especially mountain and sports biking, and on the particular entanglements of gender and class brought with them. The shift in mobility and biking from the Mao era to the postsocialist China is analyzed in the contexts of cultural......-analytical notions of global assemblages and gendered interpellations. Based on Chinese newspaper materials and fieldwork in Beijing and Shanghai, the article examines the social and gendered implications of the new biking cultures. These new biking practices mainly interpellate new middle-class men...... and masculinities as part of an exclusive leisure culture. If the “Kingdom of the Bicycles” is going to rise again, there is a need for a broader scope that addresses access for all, including women and families, as smart bikers, as well as biking as a daily mode of transportation....

  18. AHP 21: Review: The Sun Rises

    Mark Bender

    2012-12-01

    Full Text Available The Sun Rises is a model study contextualizing an oral narrative tradition in the social and ritual fabric of a remote community in northeast India. In many ways a companion volume to Himalayan Tribal Tales (Blackburn 2008, the text presents the first substantial translation of a key ritual text of the Apantani Valley dwellers in Arunachal Pradesh, located on the contested border between China (Tibet and India. The Apatani speak a Tibeto-Burman language, practice intensive rice agriculture in carefully terraced fields, and number about 35,000. Their clans populate several centuries-old villages. Until recently, they were separated from the lowlands of Assam and surrounded only by peoples practicing various forms of shifting agriculture. The valley dwellers have increasingly encountered modernization over the last few decades, including Indian and global popular culture, and Christianity. ...

  19. Understanding the Rise of African Business

    Jorem, Kaja Tvedten; Jeppesen, Søren; Hansen, Michael W.

    of African firm strategy and performance that takes into account the specificities of the African business environment and African firm capabilities. The paper starts by juxtaposing the widespread pessimistic view of African business with more recent, optimistic studies on African firms’ performance....... The latter suggests that profound improvements in African business performance are indeed under way: with the private sector playing a more important role as an engine of growth, with the rise of a capable African entrepreneurial class, and with the emergence of dynamic and competitive African enterprises...... in the literature, the authors suggest an analytical framework for understanding African business performance, underlining the interplay between contextual specificities, firm capabilities, and firm strategy....

  20. Analysis of Sea Level Rise in Action

    Gill, K. M.; Huang, T.; Quach, N. T.; Boening, C.

    2016-12-01

    NASA's Sea Level Change Portal provides scientists and the general public with "one-stop" source for current sea level change information and data. Sea Level Rise research is a multidisciplinary research and in order to understand its causes, scientists must be able to access different measurements and to be able to compare them. The portal includes an interactive tool, called the Data Analysis Tool (DAT), for accessing, visualizing, and analyzing observations and models relevant to the study of Sea Level Rise. Using NEXUS, an open source, big data analytic technology developed at the Jet Propulsion Laboratory, the DAT is able provide user on-the-fly data analysis on all relevant parameters. DAT is composed of three major components: A dedicated instance of OnEarth (a WMTS service), NEXUS deep data analytic platform, and the JPL Common Mapping Client (CMC) for web browser based user interface (UI). Utilizing the global imagery, a user is capable of browsing the data in a visual manner and isolate areas of interest for further study. The interfaces "Analysis" tool provides tools for area or point selection, single and/or comparative dataset selection, and a range of options, algorithms, and plotting. This analysis component utilizes the Nexus cloud computing platform to provide on-demand processing of the data within the user-selected parameters and immediate display of the results. A RESTful web API is exposed for users comfortable with other interfaces and who may want to take advantage of the cloud computing capabilities. This talk discuss how DAT enables on-the-fly sea level research. The talk will introduce the DAT with an end-to-end tour of the tool with exploration and animating of available imagery, a demonstration of comparative analysis and plotting, and how to share and export data along with images for use in publications/presentations. The session will cover what kind of data is available, what kind of analysis is possible, and what are the outputs.

  1. Gender inequalities in care-giving in Canada.

    Dowler, J M; Jordan-Simpson, D A; Adams, O

    1992-01-01

    In Canada today, as in the past, men and women devote different amounts of time and effort to providing health care to their family and in the broader community. This paper examines "the social distinction between masculinity and femininity" in care-giving. Issues of gender inequality in care-giving have the potential to affect the formal health care system as the burden of caring will increase over the next few decades with the aging of society. This increase in need for care is occurring at a time when primary care providers--women--have additional demand on their time. Canadian society has been facing a series of social, demographic and economic shifts such as a higher divorce rate, two-income families, women's increasing professional commitments and first pregnancies at later ages, these factors may not affect women's willingness to care for others. However women may need support to provide the care. Assuming present trends, increasing need for families to care for elderly relatives may be inevitable. Perhaps society will recognize this need and provide support to those providing informal care. This could take the form of allowing individuals more time to provide care through child care leave, leave to care for parents and job-sharing. Support to those providing informal care might also be facilitated through community support services such as respite care, household maintenance, psychological support to care-givers, support groups, informal networks within a community and consideration of unconventional support methods.

  2. The influence of relationship beliefs on gift giving

    Rai Dipankar

    2017-12-01

    Full Text Available People have fundamental beliefs about what constitutes a good relationship, known as implicit theories of relationship, where some people have destiny beliefs whereas others have growth beliefs. People with destiny beliefs believe that potential partners are meant either for each other or not, whereas people with growth beliefs believe that successful relationships are cultivated and developed. This research shows that different implicit theories of relationship influence consumers’ gift choice to their significant others. We demonstrate, through two studies, that consumers with destiny beliefs prefer giving gifts that are more feasible in nature, whereas consumers with growth beliefs prefer giving gifts that are more desirable in nature. We show that this effect is mediated by desirability-feasibility considerations. Specifically, consumers with destiny beliefs focus on feasibility considerations, which leads them to choose a highly feasible gift. Conversely, consumers with growth beliefs focus on desirability considerations, which leads them to choose a highly desirable gift. We also discuss the theoretical and managerial implications of our research.

  3. Accidents and incidents with external and/or internal radiation-exposure

    Anon.

    1990-01-01

    An individual radiation exposure accident is an unexpected and unintended event which gives rise to an overexposure (external or internal). By overexposure one means all external or internal exposure which could lead to the exceeding of the regulatory norms. Going beyond these limits does not always produce pathological manifestations. The term radiological accident is, in practice, used only when there is an occurrence of some biological or clinical response, or when some therapeutic action is required. A radio-exposure accident can occur: within or from a nuclear power plant or from a center employing ionizing radiation. These are the most frequent; and during the transport of radioactive materials. These are exceptional events. The tanks and containers used in the transport of highly radioactive substances are exhaustively studied for their resistance to accidents, and the conditions of transport determined by very strict national and international regulations. The transport of substances of low radioactivity (labelled molecules, radiopharmaceuticals...) carries only minor risks

  4. Radiation-induced segregation behavior in random and ordered face-centered cubic materials

    Bui, T.X.; Robertson, I.M.; Klatt, J.L.; Averback, R.S.; Kirk, M.A.

    1993-01-01

    Radiation-induced segregation has been studied in random solid solution alloys Ni-10%Al and Ni-6%Si, and in the ordered (L1 2 structure) intermetallics Ni 3 Si and Ni 3 Al. These materials were irradiated with 2 MeV He + ions at a temperature between 0.45 and 0.55T m and at an ion dose rate of approximately 1x10 -4 dpa per second. Subsequent Auger Electron Spectroscopy analysis showed that silicon segregated to the surface in the Ni-6% Si and Ni 3 Si alloys, and aluminum segregated away from the near surface region in the Ni-10% Al alloy. The Ni 3 Al samples exhibited no detectable segregation with respect to depth from the sample surface. The mechanisms that may give rise to this resistance to radiation induced segregation will be examined in terms of the mobility of the alloying constituents, ordering energies and atomic sizes. (orig.)

  5. Variability of radiatively forced diurnal cycle of intense convection in the tropical west pacific

    Gray, W.M.; Sheaffer, J.D.; Thorson, W.B. [Colorado State Univ., Fort Collins, CO (United States)

    1996-04-01

    Strong differences occur in daytime versus nighttime (DVN) net radiative cooling in clear versus cloudy areas of the tropical atmosphere. Daytime average cooling is approximately -0.7{degrees}C/day, whereas nighttime net tropospheric cooling rates are about -1.5{degrees}C/day, an approximately two-to-one difference. The comparatively strong nocturnal cooling in clear areas gives rise to a diurnally varying vertical circulation and horizontal convergence cycle. Various manifestations of this cyclic process include the observed early morning heavy rainfall maxima over the tropical oceans. The radiatively driven DVN circulation appears to strongly modulate the resulting diurnal cycle of intense convection which creates the highest, coldest cloudiness over maritime tropical areas and is likely a fundamental mechanism governing both small and large scale dynamics over much of the tropical environment.

  6. Chemistry with synchrotron radiation

    Preses, J.; Grover, J.R.; White, M.G.; Kvick, A.

    1990-01-01

    An accidental by-product of high-energy physics, synchrotron radiation, has emerged as one of the most powerful tools for the understanding of chemical reactions. Advances made by using synchrotron radiation in physical chemistry are reviewed herein. Descriptions of experiments exploiting the many ways that synchrotron radiation can be manipulated are presented. These manipulations include intensification of the radiation and compression or shifting of its spectral structure. Combinations of the use of synchrotron radiation, which provides access to very short wavelengths and is, at the same time, continuously and easily tunable, with laser radiation, which offers much higher resolution and much more intense radiation per pulse, but is difficult to tune in the ultraviolet region of the spectra, gives the chemist a way to map a molecule's potential energy curve, to note the lengths and strengths of chemical bonds, and to predict and explain novel reactions of more complex molecules. The use of diffraction of x-rays to study the spacing of atoms in crystals is discussed. Various applications of synchrotron radiation to studies of the fluorescence of hydrocarbons and to the chiral dichroism studies of other natural products like DNA and RNA are described. Methods for enhancing synchrotron light sources by insertion devices, such as wigglers and undulators, that increase the available photo flux and construction of new sources of synchrotron radiation are mentioned

  7. Rising workload or rising work pressure in general practice in the Netherlands.

    Bakker, D.H. de; Hutten, J.B.F.; Steultjens, M.; Schellevis, F.

    2002-01-01

    Background: General practice in the Netherlands seems to be in a crisis. Worries about shortages of GP's, the first strike of general practitioners in 2001 and the rapid increase of triage systems in out of hours care are signs that work pressure and/or workload are rising. But systematic evidence

  8. Study of the X radiation between 10 and 100 keV produced in and above the atmosphere

    Rothenflug, Robert

    1969-01-01

    To measure the X radiation within this energy range we used a detector consisting of a NaI(Tl) scintillator combined with a photomultiplier, of surface area 7 cm 2 and yield close to 1 between 10 and 100 keV. The detection system was carried by stratospheric balloons to altitudes (of the order of 40 km) where the atmosphere was sufficiently transparent to allow observation of radiation from outside the atmosphere. At the same time the atmosphere is the centre of ionising radiations which give rise to parasitic X-rays in air and in the materials surrounding the detector. The first part of this report is devoted to a study of these parasitic radiations for the purpose of calculating the different components. The second part deals with diffuse X radiation of extra-terrestrial origin. Measurements of the radiation in 3 different directions showed that it is isotropic within the limits of experimental accuracy, of the order of 20 per cent. The diffuse X-ray spectrum takes the form dN/dE = (2.1 ± 0.4).10 2 E -2.43±0.05 ph/cm 2 .s.ster.keV for E expressed in keV, between 14 and 90 keV., The last part is devoted to a discussion on the possible origins of the diffuse radiation. (author) [fr

  9. Who Is Giving Feedback To Whom In Entrepreneurship Education?

    Trolle Elmholdt, Stine; Warhuus, Jan; Blenker, Per

    evaluate and provide feedback on, with regard to both the teaching and the learning that takes place in these types of courses. We therefore ask: Who is giving feedback to whom in entrepreneurship education - and for what purpose?The intent of the paper is to develop and explore the system of feedback......The question we care about (objectives):When entrepreneurship is taught through the process of practicing entrepreneurship and based on experiential learning, a need arises for different forms of assessment, evaluation, and feedback procedures than those applied to traditional forms of higher...... is at play that involves both feedback among educators and students and between educators and students;3. that the complexity is further increased when it is acknowledged that the subject of the feedback may concern the learning, the teaching, the process, the object of the process (the entrepreneurial...

  10. Uranium oxide recycling to give more sustainable power generation

    Hagger, R.; Garner, D.S.J.; Beaumont, D.M.; Hesketh, K.

    2001-01-01

    In broad terms there are two routes for irradiated nuclear fuel, the closed cycle involving recycling and the open cycle culminating in direct disposal. The benefits of following the closed cycle are presented. The environmental burdens associated with open and closed cycles are compared using Life Cycle Assessment (LCA) for non-active burdens and human irradiation. Consideration is given to the extension of the nuclear fuel cycle to include a proportion of MOX fuel elements within a reactor core, and the impact in terms of total activity, waste volumes and Integrated Toxic Potential (ITP) discussed. The potential of moving to a fast reactor cycle is also raised in support of the recycling of spent nuclear fuel giving sustainable power generation. (author)

  11. IMPACT OF THE “GIVING CIGARETTES IS GIVING HARM” CAMPAIGN ON KNOWLEDGE AND ATTITUDES OF CHINESE SMOKERS

    Huang, Li-Ling; Thrasher, James F.; Jiang, Yuan; Li, Qiang; Fong, Geoffrey T.; Chang, Yvette; Walsemann, Katrina M.; Friedman, Daniela B.

    2015-01-01

    Objective To date there is limited published evidence on the efficacy of tobacco control mass media campaigns in China. This study aimed to evaluate the impact of a mass media campaign “Giving Cigarettes is Giving Harm” (GCGH) on Chinese smokers’ knowledge of smoking-related harms and attitudes toward cigarette gifts. Methods Population-based, representative data were analyzed from a longitudinal cohort of 3,709 adult smokers who participated in the International Tobacco Control China Survey conducted in six Chinese cities before and after the campaign. Logistic regression models were estimated to examine associations between campaign exposure and attitudes about cigarettes as gifts measured post-campaign. Poisson regression models were estimated to assess the effects of campaign exposure on post-campaign knowledge, adjusting for pre-campaign knowledge. Findings Fourteen percent (n=335) of participants recalled the campaign within the cities where the GCGH campaign was implemented. Participants in the intervention cities who recalled the campaign were more likely to disagree that cigarettes are good gifts (71% vs. 58%, pcampaign-targeted knowledge than those who did not recall the campaign (Mean=1.97 vs. 1.62, pcampaign-targeted knowledge were similar in both cities, perhaps due to a secular trend, low campaign recall, or contamination issues. Conclusions These findings suggest that the GCGH campaign increased knowledge of smoking harms, which could promote downstream cessation. Findings provide evidence to support future campaign development to effectively fight the tobacco epidemic in China. PMID:24813427

  12. Can salt marshes survive sea level rise ?

    Tambroni, N.; Seminara, G.

    2008-12-01

    Stability of salt marshes is a very delicate issue depending on the subtle interplay among hydrodynamics, morphodynamics and ecology. In fact, the elevation of the marsh platform depends essentially on three effects: i) the production of soil associated with sediments resuspended by tidal currents and wind waves in the adjacent tidal flats, advected to the marsh and settling therein; ii) production of organic sediments by the salt marsh vegetation; iii) soil 'loss' driven by sea level rise and subsidence. In order to gain insight into the mechanics of the process, we consider a schematic configuration consisting of a salt marsh located at the landward end of a tidal channel connected at the upstream end with a tidal sea, under different scenarios of sea level rise. We extend the simple 1D model for the morphodynamic evolution of a tidal channel formulated by Lanzoni and Seminara (2002, Journal of Geophysical Research-Oceans, 107, C1) allowing for sediment resuspension in the channel and vegetation growth in the marsh using the depth dependent model of biomass productivity of Spartina proposed by Morris et al. (2002, Ecology, 83, pp. 2869 - 2877). We first focus on the case of a tide dominated salt marsh neglecting wind driven sediment resuspension in the shoal. Results show that the production of biomass plays a crucial role on salt marsh stability and, provided productivity is high enough, it may turn out to be sufficient to counteract the effects of sea level rise even in the absence of significant supply of mineral sediments. The additional effect of wind resuspension is then introduced. Note that the wind action is twofold: on one hand, it generates wind waves the amplitude of which is strongly dependent on shoal depth and wind fetch; on the other hand, it generates currents driven by the surface setup induced by the shear stress acting on the free surface. Here, each contribution is analysed separately. Results show that the values of bottom stress induced by

  13. The Global Experience of Deployment of Energy-Efficient Technologies in High-Rise Construction

    Potienko, Natalia D.; Kuznetsova, Anna A.; Solyakova, Darya N.; Klyueva, Yulia E.

    2018-03-01

    The objective of this research is to examine issues related to the increasing importance of energy-efficient technologies in high-rise construction. The aim of the paper is to investigate modern approaches to building design that involve implementation of various energy-saving technologies in diverse climates and at different structural levels, including the levels of urban development, functionality, planning, construction and engineering. The research methodology is based on the comprehensive analysis of the advanced global expertise in the design and construction of energy-efficient high-rise buildings, with the examination of their positive and negative features. The research also defines the basic principles of energy-efficient architecture. Besides, it draws parallels between the climate characteristics of countries that lead in the field of energy-efficient high-rise construction, on the one hand, and the climate in Russia, on the other, which makes it possible to use the vast experience of many countries, wholly or partially. The paper also gives an analytical review of the results arrived at by implementing energy efficiency principles into high-rise architecture. The study findings determine the impact of energy-efficient technologies on high-rise architecture and planning solutions. In conclusion, the research states that, apart from aesthetic and compositional interpretation of architectural forms, an architect nowadays has to address the task of finding a synthesis between technological and architectural solutions, which requires knowledge of advanced technologies. The study findings reveal that the implementation of modern energy-efficient technologies into high-rise construction is of immediate interest and is sure to bring long-term benefits.

  14. Sea level rise and the geoid: factor analysis approach

    Song, Hongzhi; Sadovski, Alexey; Jeffress, Gary

    2013-01-01

    Sea levels are rising around the world, and this is a particular concern along most of the coasts of the United States. A 1989 EPA report shows that sea levels rose 5-6 inches more than the global average along the Mid-Atlantic and Gulf Coasts in the last century. The main reason for this is coastal land subsidence. This sea level rise is considered more as relative sea level rise than global sea level rise. Thus, instead of studying sea level rise globally, this paper describes a statistical...

  15. Analysis of radiation-natural convection interactions in 1-G and low-G environments using the discrete exchange factor method

    Kassemi, M.

    1990-01-01

    In this paper a new numerical method is presented for the analysis of combined natural convection and radiation heat transfer which has application in many engineering situations such as materials processing, combustion and fire research. Because of the recent interest in the performance of these engineering processes in the low-gravity environment of space, attention is devoted to both 1-g and low-g applications. The numerical study is based on a two-dimensional mathematical model represented by a set of coupled nonlinear partial differential equations for conservation of mass, momentum, and energy and the integro-differential equations which describe radiative heat transfer. Radiative exchange is formulated using the discrete exchange factor method (DEF). This method considers point to point exchange and provides accurate results over a wide range of radiation parameters. The desirable features of DEF are briefly described. Our numerical results show that radiation significantly influences the flow and heat transfer in the enclosure. In both low-g and 1-g applications, radiation modifies the temperature profiles and enhances the convective heat transfer at the cold wall. In a low-g environment, convection is weak, and radiation can easily become the dominant heat transfer mode. It is also shown that in the top-heated enclosure, volumetric heating by radiation gives rise to an intricate cell pattern in the cavity

  16. Drivers of Pontocaspian Biodiversity Rise and Demise

    Wesselingh, Frank; Flecker, Rachel; Wilke, Thomas; Leroy, Suzanne; Krijgsman, Wout; Stoica, Marius

    2015-04-01

    In the past two million years, the region of the Black Sea Basin, Caspian Basin and adjacent Anatolia and the Balkans were the stage of the evolution of a unique brackish water fauna, the so-called Pontocaspian fauna. The fauna is the result of assembly of genera with a Paratethyan origin and Anatolian origins during the Early Pleistocene. The rapid diversification of the Pontocaspian fauna is the result of the very dynamic nature of the lakes (the Caspian Sea is technically a lake) and seas in the region in the past two million years. In most times the various lake basins were isolated (like today), but in other episodes connections existed. Regional and global climate as well as the regional tectonic regimes were main drivers of lake basin evolution. Over the past 80 years a major biodiversity crisis is hitting the Pontocaspian faunas due to environmental degradation, pollution and invasive species. In the new EU-ETN PRIDE (Drivers of Pontocaspian Biodiversity Rise and Demise)we will be documenting the geological context of past diversifications and turnover events. We present examples of rapid turnover (biodiversity crises) in the Quaternary, assess driving forces and draw implications for the nature of the current human-mediated biodiversity crisis in the region.

  17. Gas demand to rise in the Usa

    Anon.

    2000-01-01

    Could US consumption of natural gas rise by as much as 13 quadrillion Btu (quads) over the next 20 years? A new study conducted for the American Gas Foundation by Washington Policy and Analysis says it's certainly a possibility if appropriate policies are implemented. 'Fueling the Future: Natural Gas and New Technologies for a Cleaner 21. Century', confirms what natural gas industry professionals have long suspected: changes in US energy policy that favor increased use of natural gas could improve air quality, conserve energy and reduce reliance on imported oil from politically unstable countries. Consequently, the study forecasts that the environmental, economic and efficiency advantages of natural gas-combined with advances in gas-related technologies and the introduction of new end-use technologies - could help push. US gas consumption into the 35-quad range over the next two decades. Currently, American gas demand is close to 22 quads a year. The study tracks two scenarios: a 'current projection', which shows gas demand reaching nearly 30 quads by 2020, and an 'accelerated projection', which foresees demand topping 35 quads by then based on the adoption of national policies encouraging greater use of natural gas. (authors)

  18. The Rise of Islamic Feminism in Kuwait

    Haya al-Mughni

    2012-01-01

    Full Text Available The paper examines the emergence of Islamic Feminism in Kuwait, based on the writings and personal accounts of leading Islamist women activists.  It begins with an analysis of the socio-political factors that led to the creation of Islamic groups in the 1980s. It then outlines the role of women in the growth of the Islamic movement and shows how the contradictions between women’s contributions to the Islamic cause and the secondary role they play within the Islamic organizations controlled by men were conducive to the rise of Islamic feminism in the 1990s. The paper also demonstrates how the involvement of islamist women in the struggle for suffrage forging a coalition with liberal women activists had played a decisive role in changing the position of islamist groups towards the enfranchisement of women. The last two sections of the paper look at the participation of islamist women activists in the re-definition of the dichotomy between the public and private spheres and at their involvement in the process of interpretation of Islamic sources, known as Ijtihâd. The paper concludes that the engagement of islamist women activists in the discourse of women’s rights can be powerful agent of change towards a more egalitarian society.

  19. China's rising hydropower demand challenges water sector.

    Liu, Junguo; Zhao, Dandan; Gerbens-Leenes, P W; Guan, Dabo

    2015-07-09

    Demand for hydropower is increasing, yet the water footprints (WFs) of reservoirs and hydropower, and their contributions to water scarcity, are poorly understood. Here, we calculate reservoir WFs (freshwater that evaporates from reservoirs) and hydropower WFs (the WF of hydroelectricity) in China based on data from 875 representative reservoirs (209 with power plants). In 2010, the reservoir WF totaled 27.9 × 10(9) m(3) (Gm(3)), or 22% of China's total water consumption. Ignoring the reservoir WF seriously underestimates human water appropriation. The reservoir WF associated with industrial, domestic and agricultural WFs caused water scarcity in 6 of the 10 major Chinese river basins from 2 to 12 months annually. The hydropower WF was 6.6 Gm(3) yr(-1) or 3.6 m(3) of water to produce a GJ (10(9) J) of electricity. Hydropower is a water intensive energy carrier. As a response to global climate change, the Chinese government has promoted a further increase in hydropower energy by 70% by 2020 compared to 2012. This energy policy imposes pressure on available freshwater resources and increases water scarcity. The water-energy nexus requires strategic and coordinated implementations of hydropower development among geographical regions, as well as trade-off analysis between rising energy demand and water use sustainability.

  20. The rise and fall of refineries

    Chretien, D.

    2002-01-01

    This paper described the rise and fall of refineries in Montreal. Well before Calgary, Montreal was the hub of activity for oil refineries because Montreal was the principle consuming market for petroleum products in Canada. The location was good, particularly since the soil was clay which helped prevent soil infiltration of petroleum. The first refinery in Montreal was constructed in 1916 by Esso, followed by Texaco in 1921 and Gulf in 1931. Initially oil was shipped by boat to the Port of Montreal from Saudi Arabia. Later, the petroleum came mostly from Venezuela. At the beginning of the 1980s many refineries were closed because they became obsolete and upgrading them would have been too costly. Only 3 refineries remain in Quebec, of which 2 are in Montreal. They are owned by Shell and PetroCanada. The third refinery in Quebec is in St-Romuald and is owned by UltraMar. One of the major contributing factors to the decline of the refining industry in Montreal was the decision in 1984 by former Prime Minister Trudeau to force Canadian provinces to purchase their petroleum from Alberta. This caused the petrochemical industry to locate in Sarnia in Ontario, leaving the Montreal refining centre to become obsolete. 3 figs

  1. Temperature rise of cyclicly loaded power cables

    Brakelmann, H

    1984-09-01

    A calculation method for the current ratings of cyclicly loaded power cables is introduced, taking into account optional shapes of the load cycle as well as the drying-out of the soil. The method is based on the Fourier-analysis of the loss cycle, representing an extension of the calculation method of VDE 0298. It is shown, that the ''VDE-method'' gives good results for the thermal resistances, if an ''utility load cycle'' in accordance with VDE 0298 is supposed. Only for cycles deviating essentially from the utility load cycle, the thermal resistances calculated by the ''VDE-method'' may be too great. In these cases the represented method is advantageous and can be processed by the aid of microcomputers.

  2. Giving the early fossil record of sponges a squeeze.

    Antcliffe, Jonathan B; Callow, Richard H T; Brasier, Martin D

    2014-11-01

    Twenty candidate fossils with claim to be the oldest representative of the Phylum Porifera have been re-analysed. Three criteria are used to assess each candidate: (i) the diagnostic criteria needed to categorize sponges in the fossil record; (ii) the presence, or absence, of such diagnostic features in the putative poriferan fossils; and (iii) the age constraints for the candidate fossils. All three criteria are critical to the correct interpretation of any fossil and its placement within an evolutionary context. Our analysis shows that no Precambrian fossil candidate yet satisfies all three of these criteria to be a reliable sponge fossil. The oldest widely accepted candidate, Mongolian silica hexacts from c. 545 million years ago (Ma), are here shown to be cruciform arsenopyrite crystals. The oldest reliable sponge remains are siliceous spicules from the basal Cambrian (Protohertzina anabarica Zone) Soltanieh Formation, Iran, which are described and analysed here in detail for the first time. Extensive archaeocyathan sponge reefs emerge and radiate as late as the middle of the Fortunian Stage of the Cambrian and demonstrate a gradual assembly of their skeletal structure through this time coincident with the evolution of other metazoan groups. Since the Porifera are basal in the Metazoa, their presence within the late Proterozoic has been widely anticipated. Molecular clock calibration for the earliest Porifera and Metazoa should now be based on the Iranian hexactinellid material dated to c. 535 Ma. The earliest convincing fossil sponge remains appeared at around the time of the Precambrian-Cambrian boundary, associated with the great radiation events of that interval. © 2014 The Authors. Biological Reviews © 2014 Cambridge Philosophical Society.

  3. Shapes and rising velocities of single bubbles rising through an inner subchannel

    Tomiyama, Akio; Nakahara, Yusuke; Adachi, Yoshihiro; Hosokawa, Shigeo

    2003-01-01

    Shapes and velocities of single air bubbles rising through stagnant and flowing waters in an inner subchannel are measured by making use of fluorocarbon tubes. It is confirmed that (1) bubble shapes and motions in the subchannel are by far different from those in simple geometry, and they depend on the ratio λ of the bubble diameter to the subchannel hydraulic diameter, (2) when λ > 0.9, a part of a bubble intrudes into neighboring subchannels, and thereby a kind of void drift takes place even with a single bubble, (3) the terminal velocity V T of a small bubble (λ T for cell-Taylor bubbles (λ > 0.9) is presented, and (5) the rising velocity V B in laminar an turbulent flow conditions are well evaluated by substituting the proposed V T models and the ratio of the maximum liquid velocity to the mean liquid velocity into the Nicklin correlation. (author)

  4. Regulatory Control of Radiation Sources. Safety Guide (Arabic Edition)

    2012-01-01

    This Safety Guide is intended to assist States in implementing the requirements established in Safety Standards Series No. GS-R-1, Legal and Governmental Infrastructure for Nuclear, Radiation, Radioactive Waste and Transport Safety, for a national regulatory infrastructure to regulate any practice involving radiation sources in medicine, industry, research, agriculture and education. The Safety Guide provides advice on the legislative basis for establishing regulatory bodies, including the effective independence of the regulatory body. It also provides guidance on implementing the functions and activities of regulatory bodies: the development of regulations and guides on radiation safety; implementation of a system for notification and authorization; carrying out regulatory inspections; taking necessary enforcement actions; and investigating accidents and circumstances potentially giving rise to accidents. The various aspects relating to the regulatory control of consumer products are explained, including justification, optimization of exposure, safety assessment and authorization. Guidance is also provided on the organization and staffing of regulatory bodies. Contents: 1. Introduction; 2. Legal framework for a regulatory infrastructure; 3. Principal functions and activities of the regulatory body; 4. Regulatory control of the supply of consumer products; 5. Functions of the regulatory body shared with other governmental agencies; 6. Organization and staffing of the regulatory body; 7. Documentation of the functions and activities of the regulatory body; 8. Support services; 9. Quality management for the regulatory system.

  5. Risk management strategies for the radon paradox in radiation protection

    Poffijn, A.; Eggermont, G.X.; Van Deynse, A.

    1996-01-01

    Indoor radon is recognised as being the most important radiation burden for the general public. In Belgium, as in many other countries, exposure levels giving rise to yearly risks of more than 10 -2 have been found. This latter value is normally considered unacceptable for the public. Moreover, an important fraction of the population lives in houses with radon levels of more than 400 Bq.m -3 , representing a risk level of 10 -3 per year or more. A level of this order is the limit for authorised and regulated activities at work. Prevention and intervention opportunities exist for these situations. The dose reduction opportunities are limited, but higher than the total collective dose in all nuclear activities. The analysis of radiation protection approaches, communication and decision-making for radon, compared to nuclear industrial activities shows incoherence at different levels. As a first attempt to develop a rational and coherent approach, cost-benefit analysis was applied to radon. Four optimisation scenarios were developed: three remediation and one about prevention. Referring to the α values applied by radiation protection authorities in France, Sweden and the Netherlands, the different scenarios are found to be highly justified. (author)

  6. Hazards and maximum permissible doses of radiation for man

    Walinder, G.

    1977-11-01

    Maximum permissible dose levels are primarely based on risks for genetic damage and cancer. The reason for this is the observation that such late effects of radiation seem to arise even after doses that are to low to give rise to acute effects. In contrast to the tumour incidence found in irradiated human populations no genetic effects of radiation have been observed in man. This does not mean that genetic effects have not been induced but that it has been impossible to find an increase or to discern them among all the congenital defects, that can not be ascribed to the irradiation. As a consequence, the radiological risk estimation has been concentrated on the hazard of malignant diseases. Tumour risks are generally expressed as excess rates of incidence and mortality per million persons per rem. These figures are, however, not obtained from direct epidemiological observations but have been calculated from such data under the assumption of a linear relationship between effect and radiation dose. This formal extrapolation of observed data involves an uncertainty which, of course, is proportionately greater for the calculated effects in the millirem range. However, although the calculated tumour risks can not be said to be founded on direct scientific evidence, there are scientific reasons to believe that the figures derived from the formal extrapolations constitute an upper limit of possible ri02050

  7. Regulatory Framework and Radiation Protection as Basis for Evaluation

    Elegba, S.B.

    2010-01-01

    Regulatory Framework for Nuclear Safety and Radiation Protection International Instruments: Conventions; Safety Fundamentals; Codes of Conduct; Safety Requirements and Guide, and National Instruments:-Legislation; Regulations; Guidance Documents. The Sustainable Development Principle recognizes a duty to prevent undue burden and degradation of the environment for future generations. The prime responsibility for safety must rest with the person or organization responsible for facilities…that give rise to radiation risks” (IAEA Safety Fundamentals – SF-1). Compliance with regulations and requirements imposed by the Regulatory Body shall not relieve the organization of its prime responsibility for safety. The regulatory body shall establish and implement appropriate arrangements for a systematic approach to quality management which extend throughout the range of responsibilities and functions undertaken.”. The IAEA self-assessment model for a Regulatory Body is based on a three tier approach. This model is modular and can be used and adopted for implementation by any regulator at any stage of maturity “Start up”, “On the way”, “Mature” Small, medium size, big. The IAEA is required by its Statute to promote international cooperation while regulating safety is a national responsibility. However, radiation risks may transcend national borders and international cooperation that serves to promote and enhance safety globally by exchanging experience and by improving capabilities to control hazards, to prevent accidents, to respond to emergencies and to mitigate any harmful consequences

  8. Malignant tumors arising in the maxillary region after radiation therapy

    Shimizu, Sawamichi; Shirahata, Yuichi; Uchida, Yutaka

    1984-01-01

    Although radiotherapy has proven of great therapeutic value in the treatment of malignant tumors, it should also be borne in mind that radiation has a serious potential risk of giving rise to a secondary malignancy. We recently experienced 2 cases each of carcinoma and sarcoma arising in the irradiated areas long after radiation therapy for malignant tumors. In these 4 cases, 2 males and 2 females, the primary neoplastic diseases were squamous cell carcinoma, epidermoid carcinoma, carcinoma of unknown pathology and malignant lymphoma, and the secondary tumors were epidermoid carcinoma, squamous cell carcinoma, osteosarcoma and chondrosarcoma, respectively. The sites of occurrence of these malignancies were invariably in the maxillary region; the mean latent period was 15 years, aside from an infantile case with a latent period of 5 years. In view of the primary diseases being malignant tumors the following criteria were set up for the diagnosis of radiation-induced malignancies: (1) the site of occurrence is within the confines of a previously irradiated area, (2) the latent period is prolonged and (3) the malignancy occurs as a double tumor. Therapy was primarily by operation. The prognosis was exceedingly ominous, the average survival time being 22 months. This was probably and mainly because of rapidity of tumor growth. Thus, the secondary tumors had already spread back to inward by the time they were first discovered. This should be kept in mind during a long-term follow-up of patients receiving radiotherapy for malignancy. (author)

  9. High vulnerability of the developing brain to ionizing radiation

    Inouye, Minoru

    1991-01-01

    The developing mammalian brain is highly susceptible to environmental teratogenic insults, because of its long-lasting sensitive period extending from the beginning of embryonic organogenesis to the postnatal infantile period, the great vulnerability of undifferentiated neural cells to wide range of environmental agents including ionizing radiation, and the lack of further reproductive capacity of neurons. Disturbances in the production of neurons, and their migration to the cerebral and cerebellar cortices, give rise to malformations of the brain, such as an absent corpus callosum, disorganized cortical architecture, abnormal fissuring of the cerebral and cerebellar hemispheres, heterotopic cortical gray matter, ectopic cerebellar granule cells, microcephaly, etc. The critical developmental stage for the induction of histogenetic disorders of the cerebral cortex in humans is 8 weeks of pregnancy and following some weeks. This corresponds to day 13 of pregnancy for mice and day 15 for rats, i.e., the ventricular cells of fetal telencephalon are most susceptible to radiation-induced cell death in this stage of development. The lowest doses of X- and gamma-radiations which induce detectable biological effects in rats and mice are around 0.02 Gy in increasing acute cell death. Reduced brain weight and abnormal dendritic arborization are induced by 0.25 Gy and more. Histological abnormalities are produced by 0.5 Gy and more, and microcephaly and cerebellar malformations are by 1 Gy and more. (author)

  10. Ionizing radiation, radiation sources, radiation exposure, radiation effects. Pt. 2

    Schultz, E.

    1985-01-01

    Part 2 deals with radiation exposure due to artificial radiation sources. The article describes X-ray diagnosis complete with an analysis of major methods, nuclear-medical diagnosis, percutaneous radiation therapy, isotope therapy, radiation from industrial generation of nucler energy and other sources of ionizing radiation. In conclusion, the authors attempt to asses total dose, genetically significant dose and various hazards of total radiation exposure by means of a summation of all radiation impacts. (orig./WU) [de

  11. Force acting on a spherical bubble rising through a quiescent liquid

    Takagi, Shu; Matsumoto, Yoichiro

    1996-01-01

    The direct numerical simulation is performed on the spherical bubble unsteadily rising through a quiescent liquid. The method is based on a finite-volume solution of the equations on an orthogonal curvilinear coordinate system. The calculations are performed for a bubble rising through a clean liquid and contaminated one. Following the former experimental results, the tangential stress free condition is given for a clean bubble, and no-slip condition for contaminated one. The numerical results are compared with those of the model equation of the translational motion of the bubble, which is often used in numerical models of a bubbly flow. The steady drag, added mass and history terms are checked up by the comparison. It is revealed that the history force effect is negligible for a bubble rising through the clean liquid beyond Re=O(50). From the numerical point of view, the fact that the history force is negligible is quite important, because it reduces the calculation time and memory for a bubbly flow model. For a contaminated bubble, history force effect is not negligible even though the Reynolds number is high enough. It is found that the expression of the history force by Basset kernel gives an over-estimation of the history force for the bubble rising at moderate Reynolds number. This error becomes larger with increasing Reynolds number and it reduces the accuracy to calculate the bubble motion by the model equation. (author)

  12. Using the BERT concept to promote public understanding of radiation

    Ng, Kwan-Hoong; Cameron, J.R.

    2001-01-01

    Radiation phobia can be greatly decreased if the simple BERT (Background Equivalent Radiation Time) concept is used to explain the dose to all diagnostic radiology patients. It converts the radiation dose to an equivalent period of natural background radiation. It is understandable, it does not mention risk, and it educates the patient that human-made radiation is the same as the background radiation which gives them most of their annual dose. Medical physicists should provide each clinical x-ray unit with a table that gives the BERT value for various procedures and patient sizes and educate the radiologists and radiographers how to use the BERT approach for relieving radiation anxiety. (author)

  13. Effect of LED and Argon Laser on Degree of Conversion and Temperature Rise of Hybrid and Low Shrinkage Composite Resins.

    Pahlevan, Ayob; Tabatabaei, Masumeh Hasani; Arami, Sakineh; Valizadeh, Sara

    2016-01-01

    Different light curing units are used for polymerization of composite resins. The aim of this study was to evaluate the degree of conversion (DC) and temperature rise in hybrid and low shrinkage composite resins cured by LED and Argon Laser curing lights. DC was measured using FTIR spectroscopy. For measuring temperature rise, composite resin samples were placed in Teflon molds and cured from the top. The thermocouple under samples recorded the temperature rise. After initial radiation and specimens reaching the ambient temperature, reirradiation was done and temperature was recorded again. Both temperature rise and DC data submitted to one-way ANOVA and Tukey-HSD tests (5% significance). The obtained results revealed that DC was not significantly different between the understudy composite resins or curing units. Low shrinkage composite resin showed a significantly higher temperature rise than hybrid composite resin. Argon laser caused the lowest temperature rise among the curing units. Energy density of light curing units was correlated with the DC. Type of composite resin and light curing unit had a significant effect on temperature rise due to polymerization and curing unit, respectively.

  14. Models for the rise of the dinosaurs.

    Benton, Michael J; Forth, Jonathan; Langer, Max C

    2014-01-20

    Dinosaurs arose in the early Triassic in the aftermath of the greatest mass extinction ever and became hugely successful in the Mesozoic. Their initial diversification is a classic example of a large-scale macroevolutionary change. Diversifications at such deep-time scales can now be dissected, modelled and tested. New fossils suggest that dinosaurs originated early in the Middle Triassic, during the recovery of life from the devastating Permo-Triassic mass extinction. Improvements in stratigraphic dating and a new suite of morphometric and comparative evolutionary numerical methods now allow a forensic dissection of one of the greatest turnovers in the history of life. Such studies mark a move from the narrative to the analytical in macroevolutionary research, and they allow us to begin to answer the proposal of George Gaylord Simpson, to explore adaptive radiations using numerical methods. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  15. The good engineer: giving virtue its due in engineering ethics.

    Harris, Charles E

    2008-06-01

    During the past few decades, engineering ethics has been oriented towards protecting the public from professional misconduct by engineers and from the harmful effects of technology. This "preventive ethics" project has been accomplished primarily by means of the promulgation of negative rules. However, some aspects of engineering professionalism, such as (1) sensitivity to risk (2) awareness of the social context of technology, (3) respect for nature, and (4) commitment to the public good, cannot be adequately accounted for in terms of rules, certainly not negative rules. Virtue ethics is a more appropriate vehicle for expressing these aspects of engineering professionalism. Some of the unique features of virtue ethics are the greater place it gives for discretion and judgment and also for inner motivation and commitment. Four of the many professional virtues that are important for engineers correspond to the four aspects of engineering professionalism listed above. Finally, the importance of the humanities and social sciences in promoting these virtues suggests that these disciplines are crucial in the professional education of engineers.

  16. Nasal nicotine solution: a potential aid to giving up smoking?

    Russell, M A; Jarvis, M J; Feyerabend, C; Fernö, O

    1983-01-01

    A nasal solution was developed containing 2 mg nicotine for use as a kind of liquid snuff. Its absorption was studied in three subjects. An average peak of plasma nicotine concentrations of 86.9 nmol/l (14.1 ng/ml) was reached seven and a half minutes after taking the solution. This compared with an average peak of 158.4 nmol/l (25.7 ng/ml) one and a half minutes after completing (but seven and a half minutes after starting) a middle tar cigarette (1.4 mg nicotine) and an average peak of 52.4 nmol/l (8.5 ng/ml) after chewing nicotine gum (2 mg nicotine) for 30 minutes. The more rapid and efficient absorption of nicotine from the nasal nicotine solution than from nicotine chewing gum suggests that it might prove a useful aid to giving up smoking. Nasal nicotine solution might be particularly useful in smokers for whom the gum is less suitable on account of dentures or peptic ulcers or who experience nausea and dyspeptic symptoms from the gum. PMID:6402202

  17. Does friendship give us non-derivative partial reasons ?

    Andrew Reisner

    2008-02-01

    Full Text Available One way to approach the question of whether there are non-derivative partial reasons of any kind is to give an account of what partial reasons are, and then to consider whether there are such reasons. If there are, then it is at least possible that there are partial reasons of friendship. It is this approach that will be taken here, and it produces several interesting results. The first is a point about the structure of partial reasons. It is at least a necessary condition of a reason’s being partial that it has an explicit relational component. This component, technically, is a relatum in the reason relation that itself is a relation between the person to whom the reason applies and the person whom the action for which there is a reason concerns. The second conclusion of the paper is that this relational component is also required for a number of types of putatively impartial reasons. In order to avoid trivialising the distinction between partial and impartial reasons, some further sufficient condition must be applied. Finally, there is some prospect for a way of distinguishing between impartial reasons that contain a relational component and partial reasons, but that this approach suggests that the question of whether ethics is partial or impartial will be settled at the level of normative ethical discourse, or at least not at the level of discourse about the nature of reasons for action.

  18. Complication of radiation therapy

    Imajo, Yoshinari; Suematsu, Toru; Narabayashi, Isamu; Gose, Kyuhei; Takimoto, Saeko

    1984-01-01

    The radiation pneumonitis is a major complication for patients recieving thoracic irradiation. This report describe the radiographic recognition, pathological change and imapired pulmonary functions of radiation pneumonitis. The 57 patients with lung cancer treated with radiation are analyzed on the pneumonitis by chest X-P. Among these, 50 patients (88%) develop radiation pneumonitis. Repeated CT scans give more detailed information than conventional radiograms as to exdative changes. The pathological analysis are made on the 35 patients of which affected lungs are resected after pre-operative irradiation. Three phases are recognized in the evolution of pneumonitis, the ongestive, the degenerative, and the fibrotic. Adding to the morphorogical damage, pulmonary functions also detrieorate both in ventilation and perfusion scans. (author)

  19. Radiation injuries and recovery

    Pauly, H.

    1974-01-01

    In memory of Prof. Dr. Langendorff, a survey and a cross-section are given of the development of radiobiology during the last 40 years. The importance of radiobiology is shown using several examples. The mechanisms and effects of radiation on man, animals and plants are discussed. Effects of radiation and radiolesious are explained down ot the molecular field, and their importance is discussed quantitatively with stochastic considerations. Stress is laid upon recovering from radiolesious. It is tried to explain recovery quantitatively in all its several sorts. Using all these deliberations, the author also tries to give a wide spectrum for radiation protection. These fundamental deliberations and works of Prof. Dr. Langendorff are guidelines of great importance also for radiation protection in connection with the protection of the civil population. (GSE) [de

  20. Generation of auroral kilometric and Z mode radiation by the cyclotron maser mechanism

    Omidi, N.; Gurnett, D. A.; Wu, C. S.

    1984-01-01

    The relativistic Doppler-shifted cyclotron resonance condition for EM wave interactions with a plasma defines an ellipse in velocity space when the product of the index of refraction and cosine of the wave normal angle is less than or equal to unity, and defines a partial ellipse when the product is greater than unity. It is also noted that waves with frequencies greater than the gyrofrequency can only resonate with particles moving in the same direction along the magnetic field, while waves with lower frequencies than these resonate with particles moving in both directions along the magnetic field. It is found, in the case of auroral kilometric radiation, that both the upgoing and the downgoing electrons are unstable and can give rise to this radiation's growth. The magnitudes of the growth rates for both the upgoing and downgoing auroral kilometric radiation are comparable, and indicate that the path lengths needed to account for the observed intensities of this radiation are of the order of a few hundred km, which is probably too large. Growth rate calculations for the Z mode radiation show that, for wave frequencies just below the gyrofrequency and wave normal angles at or near 90 deg, the electron distribution is unstable and the growth rates are large enough to account for the observed intensities.

  1. New approaches of organizing care and work: giving way to participation, mobilization, and innovation.

    Viens, Chantal; Lavoie-Tremblay, Mélanie; Leclerc, Martine Mayrand; Brabant, Louise Hamelin

    2005-01-01

    Quebec's health network has undertaken large-scale organizational changes to ensure the continuity, accessibility, and quality of health care and services for the population. This article describes the optimal approach for making changes to the organization of care and work for patients, health care workers, and organizations. This participative action research was carried out by means of interviews and document analysis. One hundred participants were involved, describing a total of 34 projects for significant organizational change. Results include an optimal approach broken down into 4 phases, each of which includes steps, facilitating factors, and potential difficulties. The phases of this approach are: (1) sharing the vision, mission, and values of the organization and identifying the purpose and need underlying the change; (2) building alliances and validating the involvement of the various players; (3) conceptualizing and planning the project; and (4) implementing changes and continuing evaluation. It is possible to rise to the challenge of finding new approaches to organize care and work by giving way to participation, mobilization, and innovation.

  2. Rising utilization of inpatient pediatric asthma pathways.

    Kaiser, Sunitha V; Rodean, Jonathan; Bekmezian, Arpi; Hall, Matt; Shah, Samir S; Mahant, Sanjay; Parikh, Kavita; Morse, Rustin; Puls, Henry; Cabana, Michael D

    2018-02-01

    Clinical pathways are detailed care plans that operationalize evidence-based guidelines into an accessible format for health providers. Their goal is to link evidence to practice to optimize patient outcomes and delivery efficiency. It is unknown to what extent inpatient pediatric asthma pathways are being utilized nationally. (1) Describe inpatient pediatric asthma pathway design and implementation across a large hospital network. (2) Compare characteristics of hospitals with and without pathways. We conducted a descriptive, cross-sectional, survey study of hospitals in the Pediatric Research in Inpatient Settings Network (75% children's hospitals, 25% community hospitals). Our survey determined if each hospital used a pathway and pathway characteristics (e.g. pathway elements, implementation methods). Hospitals with and without pathways were compared using Chi-square tests (categorical variables) and Student's t-tests (continuous variables). Surveys were distributed to 3-5 potential participants from each hospital and 302 (74%) participants responded, representing 86% (106/123) of surveyed hospitals. From 2005-2015, the proportion of hospitals utilizing inpatient asthma pathways increased from 27% to 86%. We found variation in pathway elements, implementation strategies, electronic medical record integration, and compliance monitoring across hospitals. Hospitals with pathways had larger inpatient pediatric programs [mean 12.1 versus 6.1 full-time equivalents, p = 0.04] and were more commonly free-standing children's hospitals (52% versus 23%, p = 0.05). From 2005-2015, there was a dramatic rise in implementation of inpatient pediatric asthma pathways. We found variation in many aspects of pathway design and implementation. Future studies should determine optimal implementation strategies to better support hospital-level efforts in improving pediatric asthma care and outcomes.

  3. The rise and fall of gluten!

    Aziz, Imran; Branchi, Federica; Sanders, David S

    2015-08-01

    Mankind has existed for 2·5 million years but only in the last 10,000 years have we been exposed to wheat. Wheat was first cultivated in the Fertile Crescent (South Western Asia) with a farming expansion that lasted from about 9000BC to 4000BC. Thus it could be considered that wheat (and gluten) is a novel introduction to man's diet! Prior to 1939 the rationing system had already been devised. This led to an imperative to try to increase agricultural production. Thus it was agreed in 1941 that there was a need to establish a Nutrition Society. The very roots of the society were geared towards necessarily increasing the production of wheat. This goal was achieved and by the end of the 20th century, global wheat output had expanded 5-fold. Perhaps as a result the epidemiology of coeliac disease (CD) or gluten sensitive enteropathy has changed. CD is a state of heightened immunological responsiveness to ingested gluten in genetically susceptible individuals. CD now affects 1 % or more of all adults, for which the treatment is a strict lifelong gluten-free diet. However, there is a growing body of evidence to show that a far greater proportion of individuals without coeliac disease are taking a gluten-free diet of their own volition. This clinical entity has been termed non-coeliac gluten sensitivity (NCGS), although the condition is fraught with complexities due to overlap with other gluten-based constituents that can also trigger similar clinical symptoms. This review will explore the relationship between gluten, the rising prevalence of modern coeliac disease, and the new entity of NCGS along with its associated uncertainties.

  4. Sea level rise under the Shared Socioeconomic Pathways (SSPs)

    Schleussner, C. F.; Nauels, A.; Rogelj, J.; Mengel, M.; Meinshausen, M.

    2017-12-01

    In order to assess future sea level rise and its impacts, we need to study climate change pathways combined with different scenarios of socioeconomic development. Here, we present Sea Level Rise (SLR) projections for the Shared Socioeconomic Pathway (SSP) storylines and different year-2100 radiative Forcing Targets (FTs). Future SLR is estimated with a comprehensive SLR emulator that accounts for latest research on additional Antarctic rapid discharge dynamics from hydrofracturing and ice cliff instability. Across all baseline scenario realizations (no dedicated climate mitigation), we find 2100 median SLR relative to 1986-2005 of 102 cm (likely range: 77 to 135 cm) for SSP1, 118 cm (90 to 151 cm) for SSP2, 118 cm (91 to 149 cm) for SSP3, 107 cm (81 to 137 cm) for SSP4, and 144 cm (112 to 184 cm) for SSP5. The 2100 sea level responses for combined SSP-FT scenarios is dominated by the mitigation targets and yield median estimates of 68 cm (56 to 87 cm) for FT 2.6 Wm-2, 76 cm (61 to 107 cm) for FT 3.4 Wm-2, 90 cm (68 to 120 cm) for FT 4.5 Wm-2, and 105 cm (79 to 136 cm) for FT 6.0 Wm-2. Average 2081-2100 annual rates of SLR are 6 mm/yr and 19 mm/yr for the FT 2.6 Wm-2 and the baseline scenarios, respectively. Our model setup allows linking scenario-specific emission and socioeconomic indicators to projected SLR. For limiting median 2100 SSP SLR projections to below 80 cm, we find that 2050 cumulative CO2 emissions since pre-industrial should not exceed around 860 GtC, with the global coal phase-out nearly completed. For SSP mitigation scenarios, the median 2050 carbon price of 90 US$2005 tCO2-1 would correspond to a median 2100 SLR of around 80 cm. Our results confirm that rapid and early emission reductions are essential for limiting 2100 SLR.

  5. Atoms, radiation, and radiation protection

    Turner, J.E.

    1986-01-01

    This book describes basic atomic and nuclear structure, the physical processes that result in the emission of ionizing radiations, and external and internal radiation protection criteria, standards, and practices from the standpoint of their underlying physical and biological basis. The sources and properties of ionizing radiation-charged particles, photons, and neutrons-and their interactions with matter are discussed in detail. The underlying physical principles of radiation detection and systems for radiation dosimetry are presented. Topics considered include atomic physics and radiation; atomic structure and radiation; the nucleus and nuclear radiation; interaction of heavy charged particles with matter; interaction of beta particles with matter; phenomena associated with charged-particle tracks; interaction of photons with matter; neutrons, fission and criticality; methods of radiation detection; radiation dosimetry; chemical and biological effects of radiation; radiation protection criteria and standards; external radiation protection; and internal dosimetry and radiation protection

  6. Basic reactions induced by radiation

    Charlesby, A.

    1980-01-01

    This paper summarises some of the basic reactions resulting from exposure to high energy radiation. In the initial stages energy is absorbed, but not necessarily at random, giving radical and ion species which may then react to promote the final chemical change. However, it is possible to intervene at intermediate stages to modify or reduce the radiation effect. Under certain conditions enhanced reactions are also possible. Several expressions are given to calculate radiation yield in terms of energy absorbed. Some analogies between radiation-induced reactions in polymers, and those studied in radiobiology are outlined. (author)

  7. Radiation notes 5

    Anon.

    1987-01-01

    A map of Austria is shown with radioactivities of yellow boletus in summer 1987. A table gives the radioactive contamination of various foods measured from 15-30 Sep 1987 in Austria. A chapter on 'Dosis' gives an example of radiation burden from fruits. It is pointed out that the reader ('people like us'), being health-conscious, consumes considerably more fruit than an average Austrian, and the calculation is for that higher fruit consumption. Chocolate and commercial baby nutriments are pointed out as potential sources of radioactive contamination. (qui)

  8. Natural radiation

    Feliciano, Vanusa Maria Delage

    2016-01-01

    Cosmic radiation, as well as cosmogenic radiation, terrestrial radiation, radon and thorium are introduced in this chapter 3. The distribution of natural radiation sources is treated, where the percentage distribution of the contribution relative to exposure to radiation from natural and artificial sources is also included

  9. Saving reed lands by giving economic value to reed

    F.W. Croon

    2014-07-01

    Full Text Available Discussions about the need for renewable energy, the need for nature conservation, the need to double the world’s food production to eliminate hunger, the need to reduce carbon dioxide emission, and the wish to reduce dependency on dwindling oil resources, show that these issues are intimately related and sometimes mutually exclusive. The use of food crops for the production of renewable fuels has resulted in the energy vs. food debate; the use of scarce land and fresh water for the dedicated production of biomass conflicts with food production and nature conservation; the collection of harvest residues and forest wastes as biomass to produce renewable fuels is complex and leaves a CO2 footprint. The several species of reed that grow naturally in deltas, river plains etc. can provide large amounts of biomass but are hardly mentioned in the debates. Harvesting reed does not threaten the nature and the natural functions of reed lands, which are carbon neutral or carbon dioxide sinks. Reed production does not need extensive infrastructure or complex cultivation and does not compete with food production for land and fresh water. Reed lands in many places are under threat of reclamation for economic activities and urbanisation. This trend can be countered if reed is seen to have a proven economic value. In this article I argue that giving a sustainable economic value to reed lands can only be realised if the exploitation is recognised as being environmentally acceptable, commercially feasible and a source of economic gains for all stakeholders. Commercial feasibility can be achieved under present economic conditions only if a reliable supply of considerable volumes of reed at a limited price can be guaranteed.

  10. Giving birth with rape in one's past: a qualitative study.

    Halvorsen, Lotta; Nerum, Hilde; Oian, Pål; Sørlie, Tore

    2013-09-01

    Rape is one of the most traumatizing violations a woman can be subjected to, and leads to extensive health problems, predominantly psychological ones. A large proportion of women develop a form of posttraumatic stress termed Rape Trauma Syndrome. A previous study by our research group has shown that women with a history of rape far more often had an operative delivery in their first birth and those who gave birth vaginally had second stages twice as long as women with no history of sexual assault. The aim of this study is to examine and illuminate how women previously subjected to rape experience giving birth for the first time and their advice on the kind of birth care they regard as good for women with a history of rape. A semi-structured interview with 10 women, who had been exposed to rape before their first childbirth. Data on the birth experience were analyzed by qualitative content analysis. The main theme was "being back in the rape" with two categories: "reactivation of the rape during labor," with subcategories "struggle," "surrender," and "escape" and "re-traumatization after birth," with the subcategories "objectified," "dirtied," and "alienated body." A rape trauma can be reactivated during the first childbirth regardless of mode of delivery. After birth, the women found themselves re-traumatized with the feeling of being dirtied, alienated, and reduced to just a body that another body is to come out of. Birth attendants should acknowledge that the common measures and procedures used during normal birth or cesarean section can contribute to a reactivation of the rape trauma. © 2013, Copyright the Authors Journal compilation © 2013, Wiley Periodicals, Inc.

  11. Simulated parents: developing paediatric trainees' skills in giving bad news.

    Gough, Jenny K; Frydenberg, Alexis R; Donath, Susan K; Marks, Michael M

    2009-03-01

    In curriculum documents for medicine in undergraduate, post-graduate and continuing professional development, there is now a focus on communication skills. The challenges are to place communication skills in the crowded curriculum and then to construct and sustain a programme that uses an evidence-based approach to the teaching and learning of communication skills. For 6 years, we have conducted a programme that involves simulated parents supporting junior medical staff to refine their skills in communication, particularly in giving parents bad news. The aim of our study was to obtain a better understanding of the trainees' experiences of the programme. Nine junior residents individually worked through two scenarios and received feedback from the simulated parent. They gave bad news to a simulated parent/actor who then gave feedback. A recording of the simulation was provided for discussion with a designated colleague at an arranged time. The tapes were then separately appraised by two independent raters - another actor and a paediatrician. Brief written reports and conducted semi-structured interviews provided more insights into the trainees' experience of the simulation. Other participating medical/medical education staff were interviewed about the simulation programme. Five themes emerged from the qualitative data: timeliness, emotional safety, the complexity of communication, practical usefulness and the challenge of effecting change. In addition, the ratings of the videos helped to clarify those 'parent-centred' communication skills that trainees may neglect in difficult conversations: 'ask about support', 'encourage the parent to ask questions' and 'repeat key messages'. The evaluation highlighted the value of an early-career experiential programme to highlight the importance of communication skills in post-graduate paediatrics practice.

  12. Radiative transfer in disc galaxies - V. The accuracy of the KB approximation

    Lee, Dukhang; Baes, Maarten; Seon, Kwang-Il; Camps, Peter; Verstocken, Sam; Han, Wonyong

    2016-12-01

    We investigate the accuracy of an approximate radiative transfer technique that was first proposed by Kylafis & Bahcall (hereafter the KB approximation) and has been popular in modelling dusty late-type galaxies. We compare realistic galaxy models calculated with the KB approximation with those of a three-dimensional Monte Carlo radiative transfer code SKIRT. The SKIRT code fully takes into account of the contribution of multiple scattering whereas the KB approximation calculates only single scattered intensity and multiple scattering components are approximated. We find that the KB approximation gives fairly accurate results if optically thin, face-on galaxies are considered. However, for highly inclined (I ≳ 85°) and/or optically thick (central face-on optical depth ≳1) galaxy models, the approximation can give rise to substantial errors, sometimes, up to ≳40 per cent. Moreover, it is also found that the KB approximation is not always physical, sometimes producing infinite intensities at lines of sight with high optical depth in edge-on galaxy models. There is no `simple recipe' to correct the errors of the KB approximation that is universally applicable to any galaxy models. Therefore, it is recommended that the full radiative transfer calculation be used, even though it is slower than the KB approximation.

  13. Radiation protection, optimization and justification; Radioprotection, optimisation et justification

    Cordoliani, Y.S.; Brisse, H.; Foucart, J.M. [75 - Paris (France); Clement, J.P.; Ribeiro, A.; Gomes, H.; Marcus, C. [51 - Reims (France); Rehel, J.L.; Talbot, A.; Aubert, B.; Scanff, P. [92 - Fontenay aux Roses (France); Roudier, C.; Donadieu, J.; Pirard, P. [Saint Maurice (France); Bar, O. [37 - Tours (France); Maccia, C.; Benedittini, M. [92 - Bourg la Reine (France); Bouziane, T. [Tournai (Belgium); Brat, H. [Hornuy (Belgium); Bricoult, M [Bruxelles (Belgium); Heuga, O.; Hauger, O.; Bonnefoy, O.; Diard, F.; Chateil, J.F. [33 - Bordeaux (France); Schramm, R. [Forcheim (Germany); Reisman, J. [Princeton (United States); Aubert, B

    2005-10-15

    Nine articles in the field of radiation protection relative to the medical examinations concern the new legislation in radiation protection, the optimization of this one in order to reduce the radiation doses delivered to the patients, the side effects induced by irradiation and to give an evaluation of the medical exposure of french population to ionizing radiations. (N.C.)

  14. Primary radiation damage and disturbance in cell divisions

    Kim, Jin Kyu; Lee, Yun-Jong; Kim, Jae-Hun; Petin, Vladislav G.; Nili, Mohammad

    2008-01-01

    Survived cells from a homogeneous population exposed to ionizing radiation form various colonies of different sizes and morphology on a solid nutrient medium, which appear at different time intervals after irradiation. Such a phenomenon agrees well with the modern theory of microdosimetry and classical hit-and-target models of radiobiology. According to the hit-principle, individual cells exposed to the same dose of radiation are damaged in different manners. It means that the survived cells can differ in the content of sublethal damage (hits) produced by the energy absorbed into the cell and which is not enough to give rise to effective radiation damage which is responsible for cell killing or inactivation. In diploid yeast cells, the growth rate of cells from 250 colonies of various sizes appeared at different time intervals after irradiation with 600 Gy of gamma radiation from a 60 Co isotopic source was analyzed. The survival rate after irradiation was 20%. Based on the analyses results, it was possible to categorize the clones grown from irradiated cells according to the number of sub-lesions from 1 to 4. The clones with various numbers of sub-lesions were shown to be different in their viability, radiosensitivity, sensitivity to environmental conditions, and the frequency of recombination and respiratory deficient mutations. Cells from unstable clones exhibited an enhanced radiosensitivity, and an increased portion of morphologically changed cells, nonviable cells and respiration mutants, as well. The degree of expression of the foregoing effects was higher if the number of primary sublethal lesions was greater in the originally irradiated cell. Disturbance in cell division can be characterized by cell inactivation or incorrect distribution of mitochondria between daughter cells. Thus, the suggested methodology of identification of cells with a definite number of primary sublethal lesions will promote further elucidation of the nature of primary radiation

  15. Organization and operation of the sixth international symposium on the natural radiation environment (NRE VI). Final report

    Hopke, P.K.

    1995-01-01

    An important source of human exposure to radiation is the natural world including cosmic rays, cosmogonic radionuclides, natural terrestrial radionuclides, and radon isotopes and its decay products. Considerable effort is being expended on a worldwide basis to characterize the exposure to the natural radiation environment and determine the important pathways for the exposure to result in dose to tissue that leads to injury and disease. The problem of background exposure to naturally occurring radioactivity has been the subject of research since the initial discovery of the radioactivity of uranium and thorium. However, with the advent of artificial sources of radiation with both benefits (medical x-rays and nuclear medicine), and harm (Chernobyl fallout), the nature and magnitude of the natural radiation environment and the effects on various populations are important in the development of overall public health strategies as ALARA principles are applied. To facilitate the exchange of information and the review of uncertainties and scientific research priorities, a series of 5 international meetings on Natural Radiation Environment, 1963, 1987, 1991. This conference (Montreal, 1995) covers the range of natural radiation environments that give rise to human exposure and dose. This document is a program summary

  16. Effects of radiation on DNA

    Medina, V.F.O.

    1978-01-01

    Irradiation has been shown to depress DNA (deoxyribonucleic acid) synthesis resulting in deficient DNA synthesis. In one experiment, Hela S 3 cells completed the next division after a dose of 500 rads to 200 kw X-rays. Another experiment showed that the amount of DNA synthesized was dependent on the stage in the generation cycle at which the cells are irradiated (Giffites and Tolmach, 1975). DNA synthesis was measured by radioactive thymidine incorporation. The smallest deficiency (20-35%) after a dose of 500 rad X-ray was observed in Hela S 3 cells irradiated in early G 1 or early G 2 , while the greatest deficiency (55-70*) after 500 rad X-ray was found in cells irradiated at mitosis or at the Gsub(1)/S transition. Using velocity sedimentation in alkaline gradients of the DNA from hamster, Elkind, et al 1972, studied repair processes as a function of X-ray dose. DNA containing material released by alkaline lysis was found initially contained in a complex-containing lipid, the sedimentation of which was anomalous relative to denatured RNA from unirradated cells. Doses of X-rays small enough to be in the range that permits high survival (100-800 rads) speed the resolution of single-stranded DNA from this DNA complex, giving rise to a species having a number average molecular weight of 2 x 10 8 daltons. Larger doses greater than 1000 to 2000 rads resulted in a degradation of these DNA strands. Incubation after irradiation resulted in the rapid repair of damage, although the rate of repair of damage to the complex resulted in a reassociation of lipid and DNA. This evidence supports the possibility that a large DNA-membrane structure is a principal target of radiation

  17. The synchrotron radiation

    Chevallier, P.

    1994-01-01

    Synchrotron Radiation is a fantastic source of electromagnetic radiation the energy spectrum of which spreads continuously from the far infrared to hard X-rays. For this reason a wide part of the scientific community, fundamentalists as well as industry, is concerned by its use. We shall describe here the main properties of this light source and give two examples of application in the field of characterization of materials: EXAFS (Extended X-Ray Absorption Fine Structure) and X-ray fluorescence. (author). 8 figs., 21 refs

  18. Quark-gluon structure of the pomeron and the rise of inclusive spectra at high energies

    Kaidalov, A.V.

    1982-01-01

    The topological expansion and the nodel of a colour tube are used for the calculation of inclusive hadronic spectra in the central region. The higher-order terms of the 1/Nsub(f)-expansion, which correspond to the contribution of the poliperipheral diagrams are taken into account. It is shown that the intrinsic motion of quarks inside colliding hadrons leads to the rise of inclusive spectra with energy in the central region. The model gives a good quantitative description of the effects observed recently at the CERN SPS Collider

  19. Radiation enteritis

    Ochsner, S.F.; Head, L.H.

    1973-01-01

    A comprehensive review of radiation enteritis is presented. Experience in clinical radiation therapy has indicated that the small bowel is the segment of the alimentary tract that is most susceptible to radiation damage. (U.S.)

  20. Radiation monitor

    Pao, C.T.; Green, W.K.

    1978-01-01

    A system for indicating radiation from a radioactive fluid such as a gas wherein simultaneous indications of the activity concentration of radioactivity of the gas, the radiation dose rate and average energy of the radiation are provided

  1. Radiation protection

    Ures Pantazi, M.

    1994-01-01

    This work define procedures and controls about ionizing radiations. Between some definitions it found the following topics: radiation dose, risk, biological effects, international radioprotection bodies, workers exposure, accidental exposure, emergencies and radiation protection

  2. Radiation sickness

    ... exposure to ionizing radiation. There are two main types of radiation: nonionizing and ionizing. Nonionizing radiation comes in the form of light, radio waves, microwaves and radar. These forms usually don't cause tissue damage. ...

  3. Sun Radio Interferometer Space Experiment (SunRISE)

    Kasper, Justin C.; SunRISE Team

    2018-06-01

    The Sun Radio Interferometer Space Experiment (SunRISE) is a NASA Heliophysics Explorer Mission of Opportunity currently in Phase A. SunRISE is a constellation of spacecraft flying in a 10-km diameter formation and operating as the first imaging radio interferometer in space. The purpose of SunRISE is to reveal critical aspects of solar energetic particle (SEP) acceleration at coronal mass ejections (CMEs) and transport into space by making the first spatially resolved observations of coherent Type II and III radio bursts produced by electrons accelerated at CMEs or released from flares. SunRISE will focus on solar Decametric-Hectometric (DH, 0.1 space before major SEP events, but cannot be seen on Earth due to ionospheric absorption. This talk will describe SunRISE objectives and implementation. Presented on behalf of the entire SunRISE team.

  4. Rise and Shock: Optimal Defibrillator Placement in a High-rise Building.

    Chan, Timothy C Y

    2017-01-01

    Out-of-hospital cardiac arrests (OHCA) in high-rise buildings experience lower survival and longer delays until paramedic arrival. Use of publicly accessible automated external defibrillators (AED) can improve survival, but "vertical" placement has not been studied. We aim to determine whether elevator-based or lobby-based AED placement results in shorter vertical distance travelled ("response distance") to OHCAs in a high-rise building. We developed a model of a single-elevator, n-floor high-rise building. We calculated and compared the average distance from AED to floor of arrest for the two AED locations. We modeled OHCA occurrences using floor-specific Poisson processes, the risk of OHCA on the ground floor (λ 1 ) and the risk on any above-ground floor (λ). The elevator was modeled with an override function enabling direct travel to the target floor. The elevator location upon override was modeled as a discrete uniform random variable. Calculations used the laws of probability. Elevator-based AED placement had shorter average response distance if the number of floors (n) in the building exceeded three quarters of the ratio of ground-floor OHCA risk to above-ground floor risk (λ 1 /λ) plus one half (n ≥ 3λ 1 /4λ + 0.5). Otherwise, a lobby-based AED had shorter average response distance. If OHCA risk on each floor was equal, an elevator-based AED had shorter average response distance. Elevator-based AEDs travel less vertical distance to OHCAs in tall buildings or those with uniform vertical risk, while lobby-based AEDs travel less vertical distance in buildings with substantial lobby, underground, and nearby street-level traffic and OHCA risk.

  5. Does a Rise in Income Inequality Lead to Rises in Transportation Inequality and Mobility Practice Inequality?

    Joko Purwanto

    2016-06-01

    Full Text Available Social and economic inequalities have sharpened in the late 20th century. During this period, Europe has witnessed a rising unemployment rate, a declining wages for the least qualified workers, a slowing of income growth, and an increasing gap between the richest and the poorest. Based on the hypothesis of the relation between socio-economic condition and mobility behaviour, it is necessary to ask how these socio-economic inequalities manifest themselves in transportation: does a rise in income inequality lead to a rise in transportation inequality and mobility practice inequality? This question is particularly relevant today as some European countries are facing high socio-economic inequalities following the financial crisis that started in 2008. Using results from transport, car ownership and mobility surveys as well as household surveys from the Paris (Île-de-France region between eighties and late nineties, this paper tries to answer this question. The results show how inequalities in transportation and mobility practice have decreased during the period in spite of an increase in income inequalities. We find that the evolution of socio-economic inequality, most specifically income inequality was simply one of the determining factors of the evolution of inequalities in transportation and mobility practice. In fact, the most important role in that evolution is not played by the evolution of income inequality but by the evolution of elasticity between transportation and income. Reducing the effects of this elasticity should be the main target of transport policies to diminish inequality in transportation and mobility practice.

  6. Application of radiation nowadays

    Habibah Adnan

    2009-01-01

    Despite of scientist know about radiation since 1890, but they have successfully developed many of application to help human life. Now, we can see that radiation was applied in medical, academic, industrial, and generating electricity. Besides that, radiations also have other applications that can help in agriculture activities, archaeology, legislation, geology, space exploration and many more. In hospital, doctor use nuclear medicine to trace, monitor and save almost thousands of people every year. According to research, 7 out of 10 American citizens had already use this services at least once in their life. Universities, college, secondary school, research center also use nuclear material in their laboratory. For example, through research, radiation can help in plants study, agriculture technique, soils study and others. Industrial sector are one sector that applied radiation widely. For example, radiation can kill almost 80 % bacteria or dangerous microorganism in food or export products. Nowadays, radiation cannot be curtailed although it can give more benefit more than risk. It depends on how we manage it.

  7. Ionizing radiation

    Kruger, J.

    1989-01-01

    Ionizing radiation results in biological damage that differs from other hazardous substances and is highly dangerous to man. Ionizing radiation cannot be perceived by man's sense organs and the biological damage cannot be detected immediately afterwards (except in very high doses). Every human being is exposed to low doses of radiation. The structure of the atom; sources of ionizing radiation; radiation units; biological effects; norms for radiation protection; and the national control in South Africa are discussed. 1 fig., 5 refs

  8. Progressive Collapse of High-Rise Buildings from Fire

    Pershakov Valerii

    2016-01-01

    Full Text Available Considers ensuring the stability of structures of high-rise buildings against progressive collapse due to fire, proposed measures to ensure the stability of high-rise buildings due to progressive collapse. The analysis of large fires in high-rise buildings with progressive collapse and review of the literature on the issue of progressive collapse. The analysis of the Ukrainian normative documents on progressive collapse resistance.

  9. Rising damp in building walls: the wall base ventilation system

    Guimaraes, A.S.; Delgado, J.M.P.Q.; Freitas, V.P. de [Faculdade de Engenharia da Universidade do Porto, Laboratorio de Fisica das Construcoes (LFC), Departamento de Engenharia Civil, Porto (Portugal)

    2012-12-15

    This work intends to validate a new system for treating rising damp in historic buildings walls. The results of laboratory experiments show that an efficient way of treating rising damp is by ventilating the wall base, using the HUMIVENT technique. The analytical model presented describes very well the observed features of rising damp in walls, verified by laboratory tests, who contributed for a simple sizing of the wall base ventilation system that will be implemented in historic buildings. (orig.)

  10. GIVE THE PUBLIC SOMETHING, SOMETHING MORE INTERESTING THAN RADIOACTIVE WASTE

    Codee, Hans D.K.

    2003-02-27

    In the Netherlands the policy to manage radioactive waste is somewhat different from that in other countries, although the practical outcome is not much different. Long-term, i.e. at least 100 years, storage in above ground engineered structures of all waste types is the first element in the Dutch policy. Second element, but equally important, is that deep geologic disposal is foreseen after the storage period. This policy was brought out in the early eighties and was communicated to the public as a practical, logical and feasible management system for the Dutch situation. Strong opposition existed at that time to deep disposal in salt domes in the Netherlands. Above ground storage at principle was not rejected because the need to do something was obvious. Volunteers for a long term storage site did not automatically emerge. A site selection procedure was followed and resulted in the present site at Vlissingen-Oost. The waste management organization, COVRA, was not really welcomed here , but was tolerated. In the nineties facilities for low and medium level waste were erected and commissioned. In the design of the facilities much attention was given to emotional factors. The first ten operational years were needed to gain trust from the local population. Impeccable conduct and behavior was necessary as well as honesty and full openness to the public Now, after some ten years, the COVRA facilities are accepted. And a new phase is entered with the commissioning of the storage facility for high level waste, the HABOG facility. A visit to that facility will not be very spectacular, activities take place only during loading and unloading. Furthermore it is a facility for waste, so unwanted material will be brought into the community. In order to give the public something more interesting the building itself is transformed into a piece of art and in the inside a special work of art will be displayed. Together with that the attitude of the company will change. We are

  11. GIVE THE PUBLIC SOMETHING, SOMETHING MORE INTERESTING THAN RADIOACTIVE WASTE

    Codee, Hans D.K.

    2003-01-01

    In the Netherlands the policy to manage radioactive waste is somewhat different from that in other countries, although the practical outcome is not much different. Long-term, i.e. at least 100 years, storage in above ground engineered structures of all waste types is the first element in the Dutch policy. Second element, but equally important, is that deep geologic disposal is foreseen after the storage period. This policy was brought out in the early eighties and was communicated to the public as a practical, logical and feasible management system for the Dutch situation. Strong opposition existed at that time to deep disposal in salt domes in the Netherlands. Above ground storage at principle was not rejected because the need to do something was obvious. Volunteers for a long term storage site did not automatically emerge. A site selection procedure was followed and resulted in the present site at Vlissingen-Oost. The waste management organization, COVRA, was not really welcomed here , but was tolerated. In the nineties facilities for low and medium level waste were erected and commissioned. In the design of the facilities much attention was given to emotional factors. The first ten operational years were needed to gain trust from the local population. Impeccable conduct and behavior was necessary as well as honesty and full openness to the public Now, after some ten years, the COVRA facilities are accepted. And a new phase is entered with the commissioning of the storage facility for high level waste, the HABOG facility. A visit to that facility will not be very spectacular, activities take place only during loading and unloading. Furthermore it is a facility for waste, so unwanted material will be brought into the community. In order to give the public something more interesting the building itself is transformed into a piece of art and in the inside a special work of art will be displayed. Together with that the attitude of the company will change. We are

  12. The social values at risk from sea-level rise

    Graham, Sonia; Barnett, Jon; Fincher, Ruth; Hurlimann, Anna; Mortreux, Colette; Waters, Elissa

    2013-01-01

    Analysis of the risks of sea-level rise favours conventionally measured metrics such as the area of land that may be subsumed, the numbers of properties at risk, and the capital values of assets at risk. Despite this, it is clear that there exist many less material but no less important values at risk from sea-level rise. This paper re-theorises these multifarious social values at risk from sea-level rise, by explaining their diverse nature, and grounding them in the everyday practices of people living in coastal places. It is informed by a review and analysis of research on social values from within the fields of social impact assessment, human geography, psychology, decision analysis, and climate change adaptation. From this we propose that it is the ‘lived values’ of coastal places that are most at risk from sea-level rise. We then offer a framework that groups these lived values into five types: those that are physiological in nature, and those that relate to issues of security, belonging, esteem, and self-actualisation. This framework of lived values at risk from sea-level rise can guide empirical research investigating the social impacts of sea-level rise, as well as the impacts of actions to adapt to sea-level rise. It also offers a basis for identifying the distribution of related social outcomes across populations exposed to sea-level rise or sea-level rise policies

  13. The social values at risk from sea-level rise

    Graham, Sonia, E-mail: sonia.graham@unimelb.edu.au [Department of Resource Management and Geography, The University of Melbourne, 221 Bouverie St., Carlton, Victoria 3053 (Australia); Barnett, Jon, E-mail: jbarn@unimelb.edu.au [Department of Resource Management and Geography, The University of Melbourne, 221 Bouverie St., Carlton, Victoria 3053 (Australia); Fincher, Ruth, E-mail: r.fincher@unimelb.edu.au [Department of Resource Management and Geography, The University of Melbourne, 221 Bouverie St., Carlton, Victoria 3053 (Australia); Hurlimann, Anna, E-mail: anna.hurlimann@unimelb.edu.au [Faculty of Architecture, Building and Planning, The University of Melbourne, Architecture and Planning Building, Parkville, Victoria 3010 (Australia); Mortreux, Colette, E-mail: colettem@unimelb.edu.au [Department of Resource Management and Geography, The University of Melbourne, 221 Bouverie St., Carlton, Victoria 3053 (Australia); Waters, Elissa, E-mail: elissa.waters@unimelb.edu.au [Department of Resource Management and Geography, The University of Melbourne, 221 Bouverie St., Carlton, Victoria 3053 (Australia)

    2013-07-15

    Analysis of the risks of sea-level rise favours conventionally measured metrics such as the area of land that may be subsumed, the numbers of properties at risk, and the capital values of assets at risk. Despite this, it is clear that there exist many less material but no less important values at risk from sea-level rise. This paper re-theorises these multifarious social values at risk from sea-level rise, by explaining their diverse nature, and grounding them in the everyday practices of people living in coastal places. It is informed by a review and analysis of research on social values from within the fields of social impact assessment, human geography, psychology, decision analysis, and climate change adaptation. From this we propose that it is the ‘lived values’ of coastal places that are most at risk from sea-level rise. We then offer a framework that groups these lived values into five types: those that are physiological in nature, and those that relate to issues of security, belonging, esteem, and self-actualisation. This framework of lived values at risk from sea-level rise can guide empirical research investigating the social impacts of sea-level rise, as well as the impacts of actions to adapt to sea-level rise. It also offers a basis for identifying the distribution of related social outcomes across populations exposed to sea-level rise or sea-level rise policies.

  14. Parametric Cherenkov radiation (development of idea)

    Buts, V.A.

    2004-01-01

    Some physical results of researches about charged particles radiation in mediums with a periodic heterogeneity and in periodic potential are reported. The development of ideas Parametric Cherenkov Radiation has shown, that in mediums, which have even a weak degree of a periodic heterogeneity of an permittivity or potential, the nonrelativistic oscillators can radiated as relativistic. They effectively radiate the high numbers of harmonics. In particular, in the carried out experiments the ultra-violet radiation was excited at action on a crystal of intensive ten-centimetric radiation. These results give the reasons to hope for making of nonrelativistic lasers on free electrons

  15. Information from the National Institute of Radiation Protection about radiation doses and radiation risks at x-ray screening

    1975-05-01

    This report gives a specification of data concerning radiation doses and risks at x-ray investigations of lungs. The dose estimations are principally based on measurements performed in 1974 by the National Institute of Radiation Protection. The radiation doses at x-ray screening are of that magnitude that the risk for acute radiation injuries is non-existent. At these low doses it has not either been able to prove that the radiation gives long-range effects as changes in the genes or cancer of late appearance. At considerable higher doses, more than tens of thousands of millirads, a risk of cancer appearance at a small part of all irradiated persons has been proved, based on the assumption that the cancer risk is proportional to the radiation dose. Cancer can thus occure at low radiation doses too. Because of the mass radiography in Sweden 1974 about twenty cases of cancer may appear in the future. (M.S.)

  16. Radiation crosslinking of polypropylene

    Nojiri, A.; Sawasaki, T.

    1984-01-01

    The radiation crosslinking of polypropylene with several kinds of polyfunctional monomers has been examined, and it has been clarified that the enhanced crosslinking may be classified into two types. In particular, the irradiation crosslinking process of polypropylene containing a polyfunctional monomer having an acryloyloxy group giving a specific gel - dose curve has been studied by infrared absorption spectrum and oxygen absorptivity measurement in comparison with the non-enhanced system. (author)

  17. Danger - guard against radiation

    Mould, R.F.

    1978-01-01

    Part 2 of this article for nurses on hazards and precautions in the use of radiation in medicine gives a brief account of the technique of afterloading, problems in the use of radioisotopes, such as 131 I, in liquid form, dose rates from commonly used isotopes, and precautions to be observed, including the use of shielding and film badges and monitors. Maximum permissible doses and a nuclear terminology chart are included. (author)

  18. Radiation, accidents, society

    1988-01-01

    This book is meant to be used as a reference book for information officers at the event of a nuclear accident. The main part is edited in alphabetical order to facilitate use under stress. The book gives a short review of the health risks of radiation, and descriptions of accidents that have occured. The index words that have been chosen for the main part of the book have been selected due to experiences in connection with incidents and accidents. (L.E.)

  19. Radiation carcinogenesis

    1978-01-01

    The Cancergram deals with all aspects of radiation carcinogenesis. The term radiation here includes U-V radiation and the entire electromagnetic spectrum, electron and other charged particle beams, neutrons, and alpha and beta radiation from radioactive substances. Abstracts included concern relationships between radiation and carcinogenesis in humans, experimental induction of tumors in animals by irradiation, studies on the mechanism of radiation carcinogenesis at the cellular level, studies of RBE, dose response or dose threshold in relation to radiation carcinogenesis, and methods and policies for control of radiation exposure in the general population. In general, this Cancergram excludes abstracts on radio-therapy, radiologic diagnosis, radiation pathology, and radiation biology, where these articles have no bearing on radiation carcinogenesis

  20. Radiation protection problems by nonionizing electromagnetic radiation in Austria

    Duftschmid, K.E.

    1984-03-01

    Since about one year an interdisciplinary study group has been established to investigate possible radiation protection problems caused by nonionizing electromagnetic radiation in this country. The aim of this project is to identify major fields of concern, to establish appropriate techniques of measurement and control and eventually develop a sound basis for future legislation. The paper gives a summary on the present results of this study. (Author)