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  1. Characterization of an extrapolation chamber and radiochromic films for verifying the metrological coherence among beta radiation fields; Caracterizacao de uma camara de extrapolacao e filmes radiocromicos para verificacao da coerencia metrologica entre campos padroes de radiacao beta

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    Castillo, Jhonny Antonio Benavente

    2011-07-01

    The metrological coherence among standard systems is a requirement for assuring the reliability of dosimetric quantities measurements in ionizing radiation field. Scientific and technologic improvements happened in beta radiation metrology with the installment of the new beta secondary standard BSS2 in Brazil and with the adoption of the internationally recommended beta reference radiations. The Dosimeter Calibration Laboratory of the Development Center for Nuclear Technology (LCD/CDTN), in Belo Horizonte, implemented the BSS2 and methodologies are investigated for characterizing the beta radiation fields by determining the field homogeneity, the accuracy and uncertainties in the absorbed dose in air measurements. In this work, a methodology to be used for verifying the metrological coherence among beta radiation fields in standard systems was investigated; an extrapolation chamber and radiochromic films were used and measurements were done in terms of absorbed dose in air. The reliability of both the extrapolation chamber and the radiochromic film was confirmed and their calibrations were done in the LCD/CDTN in {sup 90}Sr/{sup 90}Y, {sup 85}Kr and {sup 147}Pm beta radiation fields. The angular coefficients of the extrapolation curves were determined with the chamber; the field mapping and homogeneity were obtained from dose profiles and isodose with the radiochromic films. A preliminary comparison between the LCD/CDTN and the Instrument Calibration Laboratory of the Nuclear and Energy Research Institute / Sao Paulo (LCI/IPEN) was carried out. Results with the extrapolation chamber measurements showed in terms of absorbed dose in air rates showed differences between both laboratories up to de -I % e 3%, for {sup 90}Sr/{sup 90}Y, {sup 85}Kr and {sup 147}Pm beta radiation fields, respectively. Results with the EBT radiochromic films for 0.1, 0.3 and 0.15 Gy absorbed dose in air, for the same beta radiation fields, showed differences up to 3%, -9% and -53%. The beta

  2. Dosimetry characterization of the commercial CaF{sub 2} for beta radiation of {sup 90}Sr + {sup 90}Y; Caracterizacao dosimetrica de CaF{sub 2} comercial para radiacao beta de {sup 90}Sr + {sup 90}Y

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    Oliveira, Mercia L.; Caldas, Linda V.E. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)], e-mail: mlolivei@ipen.br, e-mail: lcaldas@ipen.br

    2003-07-01

    This work studies the dosimetric characteristics of the CaF{sub 2} commercial dosimetry for detection of {sup 90}Sr + {sup 90}Y beta radiation for using in the calibration of flat and concave appliers. Were determined the repetitiousness and linearity of answers of the samples, and their calibration curves.

  3. Use of low doses of cobalt 60 gamma radiation on beet (Beta vulgaris L.), carrot (Daucus carota L.) and radish (Raphanus sativus L.) seed to stimulate increase yield; Emprego da radiacao gama do cobalto 60 em sementes de beterraba (Beta vulgaris L.), cenoura (Daucus carota L.) e rabanete (Raphanus sativus L.) para estimular o aumento da producao

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    Bovi, Jose Eduardo

    2000-07-01

    The research had the aim of evaluating the effects of low doses of Cobalt-60 gamma radiation on seeds of radish (Raphanus sativus L.) cultiva Champion, cultivars Nantes Forto (european origin) and Brasilia (Rio Grande do Sul origin) carrot (Daucus carota L. var. sativus (Hoffm.) Thell), and red beet (Beta vulgaris L.) cultivar Tall Top Early Wonder before sowing, its effects on plant growth, on the yield and roots storage of two tillages: with sowing in the same day of radiation and six days after radiation seeds. The data showed that the seeds radiation did not interfered negatively on plants growth, and the species presented differences as roots production and doses on both plantation: radish with 5,0 Gy and 2,5 Gy doses respectively to the first and the second sowings, Brasilia carrot with 2,5 Gy dose to both sowings. Nantes carrot with 2,5 Gy and 5,0 Gy respectively to the first and the second sowings, and beet with 7,5 Gy and 5,0 Gy respectively to the first and the second plantations. There is not statistics difference by Tukey test (5% and 1%) and none relation between seeds radiation and loss weight on roots storage. (author)

  4. Application of low-dose gamma irradiation to extend the shelf life of minimally processed Red Beet (Beta vulgaris sp. vulgaris L.), cv. Early Wonder; Aplicacao de baixas doses de radiacao gama para extensao da vida util de beterraba vermelha (Beta vulgaris ssp. vulgaris L.), cv. Early Wonder, minimamente processada

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    Hernandez, Nilber Kenup

    2006-07-01

    This study was aimed at investigating the effects of low-dose gamma irradiation on shelf-life extension and phyto sanitary safety of minimally processed red beet with basis on physicochemical; microbiological; chemical and sensory analyses. The samples (Beta vulgaris ssp. vulgaris L.), Early Wonder cultivar, were cultivated in the experimental area of the Horticulture Sector of the Departamento de Fitotecnia of the Instituto de Agronomia, Universidade Federal Rural do Rio de Janeiro, Seropedica, RJ, as part of two experiments performed during the second semester of 2005. In each experiment, 1200 plants (40 per linear meter of terrain) were sowed. Physicochemical analyses (fresh mass; length; average diameter and total soluble solids) of the edible part of the red beets (their tuberous roots) were periodically carried out in order to assess the most appropriate time for harvest by monitoring the development of the plants. Those times were found to be 104 and 73 days after transplanting, respectively. The harvested edible part of the roots were minimally processed and separated in two groups: (1) gamma irradiated (with doses of 0.5; 1.0 and 1.5 kGy) and (2) non-irradiated (control). All samples were stored at 8 degree C. Microbiological analyses were performed during the storage period (22 and 21 days, for experiments 1 and 2, respectively) in order to evaluate the phyto sanitary quality of the samples (Salmonella sp.; coliforms and total count of mesophilic aerobic and lactic acid bacteria). The samples irradiated with 1.0 and 1.5 kGy were found to remain appropriate for consumption for 21 days, as compared to only 7 days for the control. Monitoring of chemical composition was also performed and included the determination of saccharose; glucose; fructose and vitamins B1 and B2. No difference was found between the concentrations of those vitamins in irradiated and control samples at the end of the storage period, whereas significant changes in sugar contents were

  5. Study of radiation detectors response in standard X, gamma and beta radiation standard beams; Estudo da resposta de monitores de radioprotecao em feixes padronizados de radiacao X, gama e beta

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    Nonato, Fernanda Beatrice Conceicao

    2010-07-01

    The response of 76 Geiger-Mueller detectors, 4 semiconductor detectors and 34 ionization chambers were studied. Many of them were calibrated with gamma radiation beams ({sup 37}Cs and {sup 60}Co), and some of them were tested in beta radiation ({sup 90}Sr+{sup 9'}0Y e {sup 204}Tl) and X radiation (N-60, N-80, N-100, N-150) beams. For all three types of radiation, the calibration factors of the instruments were obtained, and the energy and angular dependences were studied. For beta and gamma radiation, the angular dependence was studied for incident radiation angles of 0 deg and +- 45 deg. The curves of the response of the instruments were obtained over an angle interval of 0 deg to +- 90 deg, for gamma, beta and X radiations. The calibration factors obtained for beta radiation were compared to those obtained for gamma radiation. For gamma radiation, 24 of the 66 tested Geiger-Mueller detectors presented results for the energy dependence according to international recommendation of ISO 4037-2 and 56 were in accordance with the Brazilian ABNT 10011 recommendation. The ionization chambers and semiconductors were in accordance to national and international recommendations. All instruments showed angular dependence less than 40%. For beta radiation, the instruments showed unsatisfactory results for the energy dependence and angular dependence. For X radiation, the ionization chambers presented results for energy dependence according to the national recommendation, and the angular dependence was less than 40%. (author)

  6. Radiation effects on vitamin A and {beta}-carotene contents in bovine liver and swine pate de foie; Efeito da radiacao gama sobre a vitamina A e o {beta}-caroteno de figado bovino e suino

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    Taipina, Magda Sinigalia

    2001-07-01

    In this study, vitamin A and {beta}-carotene contents and the percent of activity retention were analyzed in 3 kGy and 30 kGy {sup 60}Co {gamma}-irradiated samples of bovine liver and swine liver pate. Six different lots of liver samples weighing 100 g obtained at the meat market were employed. Irradiation was performed with liver samples initially frozen (-15 deg C). Similarly, six different lots of swine liver pate samples weighing about 100 - 125 g , at temperature of 7 deg C were irradiated. Pre-treatments and analysis methods were those described in Instituto Adolfo Lutz Norms for food analyses. Two and five- gram samples in duplicates for bovine liver and five gram-samples for swine liver pate were used. The results showed that there were no losses of either vitamin A or provitamin A activities in the samples of bovine liver and swine liver pate irradiated with a dose of 3 kGy (retention about 100%). On the other hand, for swine liver pate samples of vitamin A were maintained after irradiation with 30 kGy. (author)

  7. The photodiodes response in beta dosimetry; Estudo da resposta de fotodiodos para dosimetria beta

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    Khoury, Helen; Amaral, Ademir; Hazin, Clovis; Melo, Francisco [Pernambuco Univ., Recife, PE (Brazil). Dept. de Energia Nuclear

    1996-12-31

    The response of the photodiodes BPY-12, BPW-34 and SFH-206 is tested for use as beta dosimeters. The results obtained show a dose-response relationships as well as less than 1% of coefficient of variation for the reproducibility of their responses. The photodiode BPY-12 has presented a better response in comparison with the others 2 refs., 1 fig., 2 tabs.

  8. Energy and angular dependence of thermoluminescent materials to beta monitoring; Dependencia energetica e angular de materiais termoluminescentes para monitoracao beta

    Energy Technology Data Exchange (ETDEWEB)

    Cecatti, Sonia Garcia Pereira; Caldas, Linda V.E. [Instituto de Pesquisas Energeticas e Nucleares, Sao Paulo, SP (Brazil)]. E-mail: scecatti@fundacentro.gov.br

    2006-11-15

    Energy and angular dependences of different thermoluminescent materials were studied with the objective to verify which type of detector would be the most appropriate for beta monitoring of workers. Three types of CaSO{sub 4}:Dy + teflon pellets were studied. The energy dependence was evaluated using standard beta radiation sources ({sup 147} Pm, {sup 2}''0{sup 4} Tl and {sup 90} Sr+{sup 90} Y). For the angular dependence study, the pellets were exposed to beta radiation of the {sup 9}'0 Sr+{sup 90} Y source, varying the incidence angle between 0 deg C and 90 deg C. In relation to the studied characteristics, the CaSO{sub 4}:Dy + 10% C dosimeters were the most adequate for use in beta monitoring of workers. (author)

  9. Evaluation of biological effect of {sup 90}Sr beta radiation in human blood cells and dose-response curve elaboration; Avaliacao do efeito biologico da radiacao beta do {sup 90}Sr em celulas sanguineas humanas e elaboracao de curva dose-resposta

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Elaine Mendes de

    2000-07-01

    Among several environmental genotoxins, ionizing radiation has been received special attention because of its mutagenic, carcinogenic and teratogenic potential. In this context, the aim of this study was evaluate the effects of {sup 90}Sr beta radiation in human cells, in view of the scarcity of literature data. For that, blood cells of five healthy donors were irradiated in vitro with doses between 0.2 and 5.0 Gy in a {sup 90}Sr source (0.2 Gy/min) and were processed for chromosome aberration analysis and for comet assay. Cytogenetic results showed that the type of structural chromosome aberrations found more frequently were acentric fragments, double minutes and dicentrics. The values of {alpha} and {beta} coefficient of linear-quadratic model used to fit dose response curves showed that {sup 90}Sr beta radiation was more efficient in induction of lesions from only one ionizing track than two independent tracks in chromosome aberration formation. Apparently, {sup 90}Sr beta radiation neither influenced the modal number of chromosome in irradiated cells nor in cell cycle kinetic of analyzed dose interval. Concerning the comet assay, there was an increase in DNA migration in a dose dependent manner, evaluated by either image analysis system (tail moment) or visual classification (DNA damage), which dose-response relation was adequately fitted to non-linear regression model. Both adopted techniques were complement in evaluating the biological effect of {sup 90}Sr beta radiation in human cells. (author)

  10. Elaboration of supports for beta emitting sources (with vyns); Elaboracion de soportes para fuentes emisoras beta (con vyns)

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    Cortes P, A.; Torre O, J. De la; Tejera R, A.; Becerril V, A.; Bribiesca S, L

    1990-04-15

    The Laboratory of Radioactive patterns account with a 4 {pi}{beta}-{gamma} coincidence system of recent acquisition with which absolute measures of radioactive activity with uncertainties of the order of 0.1% can be made. Since the coincidence method for the activity measure consists on detecting to the particle and the photon corresponding to oneself nuclear disintegration, it is necessary to elaborate special radioactive sources on thin supports, in order to allowing the maximum possible fluence of {beta} particles ({approx} 100%). This work a technique for the elaboration of these sources and for the measure of the thickness of the walls of the support is presented. (Author)

  11. Energy and angular dependence of thermoluminescent materials for beta monitoring; Dependencia energetica e angular de materiais termoluminescentes para monitoracao beta

    Energy Technology Data Exchange (ETDEWEB)

    Cecatti, S.G.P. [Fundacao Jorge Duprat Figueiredo de Seguranca e Medicina do Trabalho (FUNDACENTRO), Sao Paulo, SP (Brazil); Caldas, L.V.E. [Instituto de Pesquisas Energeticas e Nucleares, (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2004-07-01

    This work has as objective the study of the energy and angular dependence of different thermoluminescent (TL) materials for an appropriate choice of the material to be used for beta monitoring of workers. Three types of CaSO{sub 4}:Dy + Teflon pellets were studied. The energy dependence was verified using standard sources of beta radiation ({sup 147}Pm, {sup 204}Tl and {sup 90}Sr + {sup 90}Y). For the angular dependence study the pellets were irradiated with beta radiation of the {sup 90}Sr + {sup 90}Y source, varying the incidence angle between 0 deg C and 90 deg C. The CaSO{sub 4}: Dy (50 mg) and of CaSO{sub 4}:Dy (20 mg) pellets presented practically the same high energy dependence, while the CaSO{sub 4}:Dy + 10% C pellets presented a dependence with the energy of 60% in the studied interval. The TL response of the three materials presented an accentuated angular dependence starting from 45 deg C. The dosimeters of CaSO{sub 4}:Dy + 10% C showed to be the most adequate for use in beta monitoring of workers, in relation to the studied characteristics. (author)

  12. Dependência energética e angular de materiais termoluminescentes para monitoração beta

    OpenAIRE

    CECATTI, SONIA G.P.; CALDAS, LINDA V.E.

    2014-01-01

    As dependências energética e angular de diferentes materiais termoluminescentes foram estudadas com o objetivo de verificar que tipo de detector seria o mais adequado para a monitoração de trabalhadores envolvidos com a radiação beta. Três tipos de pastilhas de CaSO4:Dy + teflon foram estudados. A dependência energética foi verificada usando-se fontes padrões de radiação beta (147Pm, 204Tl e 90Sr+90Y). A dependência angular foi verificada irradiando-se as amostras com feixes de radiação beta,...

  13. Digestibilidade de alimentos protéicos e energéticos para fêmeas de beta Digestibility of protein feedstuffs and energetic feedstuffs for female beta

    Directory of Open Access Journals (Sweden)

    Jener Alexandre Sampaio Zuanon

    2007-08-01

    Full Text Available Foram avaliados os coeficientes de digestibilidade aparente de MS, PB, energia bruta (EB e EE de alimentos protéicos (farelo de soja e farinha de peixe e energéticos (fubá de milho e farelo de trigo para beta (Betta splendens. Fêmeas adultas foram alojadas em gaiolas e mantidas em dois aquários de fibra de vidro (30 peixes/aquário para alimentação e dois para coleta de fezes, ambos de formato cônico e com capacidade para 30 L. Os resultados dos coeficientes de digestibilidade aparente de MS, PB, EB e EE foram, respectivamente, de 69,43; 72,52; 67,91 e 55,50% para farelo de soja; 60,67; 51,15; 75,55 e 58,26% para farinha de peixe; 63,88; 87,16; 77,61 e 50,40% para fubá de milho; e 61,06; 93,37; 58,17 e 65,51% para farelo de trigo. Os resultados obtidos neste estudo permitem otimizar a formulação de dietas práticas balanceadas, economicamente viáveis para a espécie.Apparent digestibility coefficients of dry matter, crude protein, gross energy and ether extract from protein feeds: soybean meal and fish meal and from energy feeds: corn and wheat middlings were evaluated for Siamese fighting fish (Betta splendens. Adult female fish were stocked in cages and held in two fiberglass aquaria (30 fish/aquarium for feeding and two aquaria for collect fecal samples, both with conic shape with 30L. The results of apparent digestibility coefficients for DM, CP, GE and EE were respectively 69.43, 72.52, 67.91 and 55.50% for soybean meal; 60.67, 51.15, 75.55 and 58.26% for fish meal; 63.88, 87.16, 77.61 and 50.40% for corn and 61.06, 93.37, 58.17 and 65.51% for wheat middlings. The determined digestibility values are essential to economically viable practical diet formulation for Siamese fish fighting.

  14. Methodology to determine the efficiency of a beta emitter gases monitor; Metodologia para determinacao da eficiencia de um monitor de gases emissores de particulas beta

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    Carvalho, Marcos Rodrigues de

    1995-07-01

    This work presents a methodology developed to determinate the efficiency of air monitors used to measure the concentration of beta emitters noble gases in nuclear power stations. Efficiency values, obtained by means of theoretical computation are compared with experimental values. The experimental part of the work was performed using three different point beta source, to simulate small amounts of gas uniformly distributed in small volume. The comparison shows that theoretical an experimental values agree within 4,2 % for {sup 90}Sr + {sup 90}Y, {sup 204}Tl and {sup 45}Ca beta sources. (author)

  15. Prueba de homogeneidad de la dispersión para datos de proporción sobredispersos mediante regresión beta

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    Mario Morales

    2014-06-01

    Full Text Available En este artículo se propone un procedimiento para verificar la hipótesis de homogeneidad del parámetro de dispersión usando regresión beta, cuando se tienen datos de proporción sobredispersos. Se demuestra que es posible analizar este tipo de datos usando un modelo lineal generalizado usual ponderado, con pesos obtenidos mediante la regresión beta. Esta forma de proceder permite corregir el problema de la dispersión extra, manteniendo la sencillez del análisis. Además, para algunos casos particulares, se evalúa mediante un estudio de simulación, la potencia de la prueba. Abstract. In this paper we propose an approach to validate the hypothesis of homogeneity of the dispersion parameter using beta regression, when we have overdispersed proportions data. We corroborated that it is possible to analyze this type of data with an usual weighted generalized linear model, weighting the observations with weights obtained through beta regression. This procedure allows to correct the problem of overdispersion keeping the simplicity of the analysis. Furthermore, for several cases, we made a simulation study of the power of the test.

  16. Procedure for the elaboration of extended sources beta and/or gamma emitting; Procedimiento para la elaboracion de fuentes extendidas emisoras beta y/o gamma

    Energy Technology Data Exchange (ETDEWEB)

    Tejera R, A.; Cortes P, A.; Becerril V, A

    1991-12-15

    In the laboratory of radioactive standards they have been come manufacturing punctual sources gauged gamma emitting during several years. Before the demand of extended radioactive homogeneous sources of beta particles emitting, in particular with nuclides that are simultaneously gamma and beta emitting, it was designed a procedure for it elaboration based on the one that we use at the moment for the elaboration of the punctual gamma sources. This procedure consists on the integration of a compact group of this type of sources on a single extended support, sealed one of its faces with a film of transparent material in satisfactory grade to the beta particles. In this work this procedure is described and it is applied in the elaboration of two sources that its were requested by the Laguna Verde Central (CFE), one with area of 20 cm{sup 2} and the other one of 100 cm{sup 2}. The homogeneity, measure as the dispersion of the activities of the aliquot ones distributed in the active surfaces was inside 2%. The percentage of attenuation of the beta particles was also measured by the film (window) with the one that the sources were sealed. (Author)

  17. Characterization of Ca So{sub 4}:Dy thermoluminescent dosimeters with graphite for absorbed doses evaluation of X-radiation and gamma radiation; Caracterizacao de dosimetros termoluminescentes de CaSo{sub 4}:Dy com grafite para avaliacao de dose absorvida de radiacao X e gama

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    Daros, Kellen Adriana Curci; Rodrigues, Leticia Lucente Campos; Medeiros, Regina Bitelli [Universidade Federal de Sao Paulo, SP (Brazil). Escola Paulista de Medicina. Dept. de Diagnostico por Imagem

    1996-12-31

    Dosimeters of Ca So{sub 4}:Dy are investigated in pellets with different thickness (0.2 to 0.8 mm) and with graphite contents between 0 and 20% by weight (0; 0.5; 3; 5; 10 and 20%). It is reported that these dosimeters can be used in dose measurements in mixed beta-photons fields. Previous TL results, for these pellets in beta fields are shown. The best results of sensitivity and energy dependence for photons are presented 3 refs., 2 figs.

  18. Design and device construction for plane tables preparation for counter alpha/beta total; Diseno y construccion de dispositivo para preparacion de planchetas para contador alfa/beta total

    Energy Technology Data Exchange (ETDEWEB)

    Galicia C, F. J.; Monroy G, F., E-mail: fgalicia82@yahoo.com [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2014-10-15

    This work presents the design and assembly of a device for plane tables preparation for quantification alpha/beta total of radioactive waste samples. The determination of the activity index alpha/beta total is used to detect a wide variety of matrices quickly and the concentration of alpha and/or beta emitters of the contained radionuclides in different samples. In particular, the determination of the activity index alpha and beta total of radioactive wastes involves the digestion of samples in aggressive means that will be evaporated to dryness for its quantification. With the purpose of controlling the emission of corrosive gases during the preparation of the plane tables for the quantification of the index alpha and beta total, was designed and built the device in the Radioactive Waste Laboratory that allows to prepare plane tables for proportional counters in a sure and efficient way. The device is constituted by heating equipment, evaporation cylinder and a gases cleaning system. The self-absorption curve got ready starting from the device. (Author)

  19. Code Betal to calculation Alpha/Beta activities in environmental samples; Programa de ordenador Betal para el calculo de la actividad Beta/Alfa de muestras ambientales

    Energy Technology Data Exchange (ETDEWEB)

    Romero, L.; Travesi, A.

    1983-07-01

    A codes, BETAL, was developed, written in FORTRAN IV, to automatize calculations and presentations of the result of the total alpha-beta activities measurements in environmental samples. This code performs the necessary calculations for transformation the activities measured in total counts, to pCi/1., bearing in mind the efficiency of the detector used and the other necessary parameters. Further more, it appraise the standard deviation of the result, and calculus the Lower limit of detection for each measurement. This code is written in iterative way by screen-operator dialogue, and asking the necessary data to perform the calculation of the activity in each case by a screen label. The code could be executed through any screen and keyboard terminal, (whose computer accepts Fortran IV) with a printer connected to the said computer. (Author) 5 refs.

  20. Extração do corante da beterraba (Beta vulgaris) para utilização como indicador ácido-base

    OpenAIRE

    Cuchinski, Ariela Suzan; Caetano, Josiane; Douglas C. Dragunski

    2010-01-01

    No presente trabalho, foi investigado o comportamento do extrato aquoso e alcoólico da beterraba (Beta vulgaris) como um indicador ácido-base, tendo como objetivo principal despertar o interesse pelo uso dos indicadores naturais, como alternativa didática para transmissão dos conceitos de titulação, equilíbrio químico e a lei de Lambert-Beer. Para a realização dos experimentos foram utilizadas soluções padrão de ácido clorídrico (HCl), ácido acético e hidróxido de sódio (NaOH). Inicialmente f...

  1. Teste de neutralização para toxina épsilon e titulação de toxinas beta e épsilon de Clostridium perfringens tipos C e D em cultura de células

    OpenAIRE

    Milton Formiga de Souza Junior

    2005-01-01

    Avaliou-se s sensibilidade das linhagens celulares Madin darby kidney bovine cells (MDBK), Madin darby canine cells (MDCK), African green momkey (VERO), Linfosarcoma de ás toxinas beta e epsilon de Clostridium perfringens tipos C e D respectivamente. Desenvolveram-se e padronizaram-se uma técnica de titulação em linhagens celular e um teste de soroneutralização in vitro para toxina épsilon; A L 929 foi a linhagem celular mais sensível à toxina beta e a MDCK à toxina beta e a MDCK à toxinica é...

  2. The use of Gamma radiation of Cobalt-60 to control avocado moth Stenoma catenifer Walsingham, 1912 (Lepidoptera: Elachistidae) and its effects on the quality of the fruit of Persea americana (Miller) (Lauraceae).; Uso da radiacao gama do Cobalto-60, para controlar a broca-do-abacate Stenoma catenifer Walsingham, 1912 (Lepidoptera: Elachistidae) e seus efeitos na qualidade do fruto de Persea americana (Miller) (Lauraceae)

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    Silva, Lilian Karla Figueira da

    2004-07-01

    doses capable to promote the sterilization of the insect, without committing your qualities physical-chemistries and sensorial of the fruits. Therefore, it is suggested the treatment with the dose of 50 Gy for fruits infested with eggs and 150 Gy for fruits infested with caterpillars and pupas of S. catenifer, maintained in temperature of 10 deg C. Para the use of the Technique of the Sterile Insect it is recommended the irradiation of pupas and adults with doses of 150 Gy and 200 Gy, respectively. (author)

  3. Beta Blockers

    Science.gov (United States)

    Beta blockers Beta blockers, also called beta-adrenergic blocking agents, treat a variety of conditions, such as high blood pressure and migraines. ... this class of medication. By Mayo Clinic Staff Beta blockers, also known as beta-adrenergic blocking agents, are ...

  4. DIFERENCIAÇÃO E FOCO PARA OBTENÇÃO DE VANTAGEM COMPETITIVA: O CASO DA BETA SISTEMAS

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    Roberta Rodrigues Faoro

    Full Text Available Este caso expõe elementos para reflexões e discussões sobre posicionamentos estratégicos em uma empresa de desenvolvimento de softwares e consultoria em tecnologia da informação. Com sede na Serra Gaúcha, a empresa atua em todo o território nacional, sendo que os seus principais clientes estão localizados nos estados do Rio Grande do Sul, Santa Catarina, São Paulo, Bahia e Mato Grosso do Sul. O caso se desdobra a partir da volta de uma viagem do jovem proprietário da empresa de desenvolvimento de softwares e consultoria em tecnologia da informação à Salvador, onde o mesmo fechou mais um grande projeto com um dos seus melhores clientes do setor de fruticultura, mas ao invés de estar contente estava muito preocupado sobre como iria entregar o projeto no prazo acordado entre as partes, em virtude de sua equipe estar sobrecarregada de trabalho. Afinal, atendendo clientes de mais de trinta ramos de atividades a empresa enfrenta um dilema estratégico: especializar-se ou pulverizar sua atuação em diversos setores? Portanto, qual estratégia a empresa deveria escolher? Os dados para a elaboração deste caso de ensino foram obtidos através de entrevistas semiestruturadas com os gestores e por meio de dados secundários como documentos internos, sites e observação direta. Este caso pode ser utilizado como ferramenta auxiliar de ensino, principalmente em disciplinas relacionadas à estratégia, na graduação e pós-graduação lato sensu do curso de administração.

  5. Aspectos biofarmacêuticos da formulação de medicamentos para neonatos: fundamentos da complexação de indometacina com hidroxipropil-beta-ciclodextrina para tratamento oral do fechamento do canal arterial Biopharmaceutical aspects of drug formulation for neonatology: rational for indomethacin's complexation with hydroxypropyl-beta-cyclodextrin to treat patent ductus arteriosus

    Directory of Open Access Journals (Sweden)

    Ana Cristina Ribeiro Rama

    2005-09-01

    Full Text Available A terapêutica farmacológica em recém-nascidos confronta-se, por um lado, com um organismo sujeito a marcadas alterações biológicas, resultantes da composição orgânica e da maturação funcional, que decorre a diferentes graus em crianças com a mesma idade, determinando modificações no perfil farmacocinético e farmacodinâmico e, por outro lado, com a necessidade efetiva da utilização de fármacos. Para dar resposta à necessidade de tratamento destes doentes, recorre-se à utilização de medicamentos "off label", sendo esta uma prática com um elevado risco de segurança e de eficácia, na ausência de informação acerca da estabilidade, solubilidade e biodisponibilidade. Considerou-se, assim, que a utilização de derivados das ciclodextrinas altamente solúveis em água seria uma alternativa para a formulação de preparações líquidas aquosas de fármacos fracamente solúveis, aliada à melhoria de biodisponibilidade e de segurança. Esta revisão pretende fundamentar a possibilidade de recurso à complexação de indometacina com hidroxipropil-beta-ciclodextrina, com o objetivo de melhorar as características de biodisponibilidade e de segurança e permitir a administração por via oral para o tratamento farmacológico do fechamento do canal arterial em prematuros ou em recém-nascidos com esta patologia.Pharmacological therapy for newborns is faced on one hand, with an organism characterized by biological differences and functional immaturity with various grades of evolution for the same age, implying changes on the pharmacokinetic and pharmacodinamic medicine profiles. On the other hand, there is the effective need for pharmacotherapy. The "off label" use of medicines is therefore the only thing left to do, having in mind the risk of using therapeutic agents not studied for this special group of people. On this context it has been considered the use of cyclodextrin derivatives like hydroxypropyl-beta-cyclodextrin as an

  6. Regulation of use of radiation for quarantine purposes; Regulamentacao do uso da radiacao para fins quarentenarios

    Energy Technology Data Exchange (ETDEWEB)

    Itepan, Natanael Marcio, E-mail: natanael.itepan@unianhanguera.edu.b [Faculdade Anhanguera, Piracicaba, SP (Brazil); Costa, Neivaldo; Furlan, Gilberto Ribeiro; Walder, Julio Marcos Melges, E-mail: neivaldo@cena.usp.b, E-mail: gilfurlan@cena.usp.b, E-mail: jmwalder@cena.usp.b [Centro de Energia Nuclear na Agricultura (CENA/USP), Piracicaba, SP (Brazil)

    2011-07-01

    The main aspects of Instruction No. 9 are: a) the nuclear plant that use ionizing radiation as a phyto sanitary treatment for quarantine purposes, must be accredited by the agency of the Agriculture, Livestock and Supply Ministry (MAPA) and the licensing by the Nuclear Energy National Commission (CNEN) and other regulatory bodies, b) control of the applied dose will follow a standard operating procedure should be performed by independent organization, authorized by the Brazilian ONPF (Phyto sanitary Protection National Organization), c) the unit of radiation treatment should ensure traceability and must maintain records of phyto sanitary treatments, d) there should be bilateral work plan between the ONPF of Brazil and other countries for the established radiation treatment protocol. The ONPF of Brazil is the Sanitary Vegetarian Department. Ionizing radiation (cold pasteurization) is shown in an alternative technology to phyto sanitary control for quarantine purposes. (author)

  7. Internal dosimetry for blood vessels radiotherapy; Dosimetria interna para terapia com radiacao em vasos sanguineos

    Energy Technology Data Exchange (ETDEWEB)

    Campos, Laelia Pumilla Botelho [Pernambuco Univ., Recife, PE (Brazil). Dept. de Energia Nuclear] E-mail: lpbcampos@uol.com.br; Stabin, Michael Gregory [Vanderbilt Univ., Nashville, TN (United States). Dept. of Radiology and Radiological Sciences] E-mail: Michael.Stabin@mcmail.vanderbilt.edu

    2001-07-01

    Among the cardiovascular diseases, the most common is acute myocardial infarction, which occurs because of the occlusion of one or more coronary arteries. Balloon angioplasty has been a popular treatment which is less invasive than surgeries involving revascularization of the myocardium, thus promising a better quality of life for patients. Unfortunately, the rate of restenosis (re-closing of the vessel) after balloon angioplasty is high (approximately 30-50% within the first year after treatment). Known as Intravascular Brachytherapy, the technique has been used with several radiation sources, and researchers have obtained success in decreasing the rate of restenosis. In order to study the radiation dosimetry in the patient and radiological protection for this therapy, radiation dose distributions for monoenergetic electrons and photons (at nine discrete energies) were calculated for blood vessels of diameter 0.15, 0.30 and 0.45 cm with balloon and wire sources using the radiation transport code MCNP4B. Specific calculations were carried out for several radionuclides. Advantages and disadvantages of the radionuclides and source geometries are discussed and the dosimetry developed here will aid in the realization of the benefits obtained in patients. (author)

  8. Radioactive contamination in monitors received for calibration; Contaminacao em monitores de radiacao recebidos para calibracao

    Energy Technology Data Exchange (ETDEWEB)

    Dias, Paulo S.; Santos, Gilvan C. dos; Brunelo, Maria Antonieta G.; Paula, Tiago C. de; Pires, Marina A.; Borges, Jose C. [MRA Comercio de Instrumentos Eletronicos Ltda., Jardinopolis, SP (Brazil). Centro de Ensaios e Pesquisas em Metrologia (METROBRAS)

    2013-10-01

    The Calibration Laboratory - LABCAL, from the Research Center for Metrology and Testing - METROBRAS, MRA Comercio de Instrumentos Eletronicos Ltda., began activities in October 2008 and, in August 2009, decided to establish a procedure for monitoring tests, external and internal, of all packages received from customers, containing instruments for calibration. The aim was to investigate possible contamination radioactive on these instruments. On July 2011, this procedure was extended to packagings of personal thermoluminescent dosemeters - TLD, received by the newly created Laboratory Laboratorio de Dosimetria Pessoal - LDP . In the monitoring procedure were used monitors with external probe, type pancake, MRA brand, models GP - 500 and MIR 7028. During the 37 months in which this investigation was conducted, were detected 42 cases of radioactive contamination, with the following characteristics: 1) just one case was personal dosimeter, TLD type; 2) just one case was not from a packing from nuclear medicine service - was from a mining company; 3) contamination occurred on packs and instruments, located and/or widespread; 4) contamination values ranged from slightly above the level of background radiation to about a thousand fold. Although METROBRAS has facilities for decontamination, in most cases, especially those of higher contamination, the procedure followed was to store the contaminated material in a room used for storage of radioactive sources. Periodically, each package and/or instrument was monitored, being released when the radiation level matched the background radiation. Every contamination detected, the client and/or owner of the instrument was informed. The Brazilian National Energy Commission - CNEN, was informed, during your public consultation for reviewing the standard for nuclear medicine services, held in mid-2012, having received from METROBRAS the statistical data available at the time. The high frequency of contamination detected and the high level of some them, is a warning that requires immediate considerations by all parties involved: CNEN, the nuclear medicine services and calibration laboratories. A first analysis of these occurrences points, as the cause, the lack of periodic control of working conditions with regard to contamination of both radiation monitors as countertops handling unsealed radioactive materials, since, in the Brazilian legislation, standards already exist to prevent such occurrences. (author)

  9. Semiconductor scintillator detector for gamma radiation; Detector cintilador semicondutor para radiacao gama

    Energy Technology Data Exchange (ETDEWEB)

    Laan, F.T.V. der; Borges, V.; Zabadal, J.R.S., E-mail: ftvdl@ufrgs.br, E-mail: borges@ufrgs.br, E-mail: jorge.zabadal@ufrgs.br [Universidade Federal do Rio Grande do Sul (GENUC/DEMEC/UFRGS), Porto Alegre, RS (Brazil). Grupo de Estudos Nucleares. Departamento de Engenharia Mecanica

    2015-07-01

    Nowadays the devices employed to evaluate individual radiation exposition are based on dosimetric films and thermoluminescent crystals, whose measurements must be processed in specific transductors. Hence, these devices carry out indirect measurements. Although a new generation of detectors based on semiconductors which are employed in EPD's (Electronic Personal Dosemeters) being yet available, it high producing costs and large dimensions prevents the application in personal dosimetry. Recent research works reports the development of new detection devices based on photovoltaic PIN diodes, which were successfully employed for detecting and monitoring exposition to X rays. In this work, we step forward by coupling a 2mm anthracene scintillator NE1, which converts the high energy radiation in visible light, generating a Strong signal which allows dispensing the use of photomultipliers. A low gain high performance amplifier and a digital acquisition device are employed to measure instantaneous and cumulative doses for energies ranging from X rays to Gamma radiation up to 2 MeV. One of the most important features of the PIN diode relies in the fact that it can be employed as a detector for ionization radiation, since it requires a small energy amount for releasing electrons. Since the photodiode does not amplify the corresponding photon current, it must be coupled to a low gain amplifier. Therefore, the new sensor works as a scintillator coupled with a photodiode PIN. Preliminary experiments are being performed with this sensor, showing good results for a wide range of energy spectrum. (author)

  10. Two-dimension multiwire detector for ionizing radiation; Detector multifilar bidimensional para radiacao ionizante

    Energy Technology Data Exchange (ETDEWEB)

    Barberino, Carlos Henrique

    1993-12-31

    A multiwire proportional Counter of 100 x 100 mm{sup 2} sensitive area has been developed. The chamber is formed by three planes: a cathode plane of 50 {mu}m gold coated tungsten wires stretched on an Epoxi frame; and anode plane made of 20 {mu}m gold plated tungsten wires stretched at 45 deg C with respect to the first cathode wires; and second cathode plane made of copper strips on a printed circuit board at 90 deg C with respect to the first cathode. The cathode strips are connected to the taps of delay-lines chips. The position of the incidence of radiation is extracted by measuring the time difference of the pulse arriving at the extremities of the delay-line chain for each coordinate. The performance of the detector has been tested using 5.89 KeV X-rays from a {sup 55} Fe source, and 8.04 KeV from Rigaku X-rays generator, operating the detector with 90% Ar + 10% CH{sub 4} gas mixture at 930 mbar. An energy resolution of 26% was obtained. An integral non linearity better than 0.3% and a position resolution better than 1 mm have been observed. The information corresponding to each one of the coordinates were digitized by a TDC in a CAMAC system and stored event by event in a micro-computer (IBM-AT). (author) 56 refs., 68 figs.

  11. Erupção acneiforme aguda induzida por interferon beta-1b durante tratamento para esclerose múltipla Acute acneiform eruption induced by interferon beta-1b during treatment for multiple sclerosis

    Directory of Open Access Journals (Sweden)

    Dário Júnior de Freitas Rosa

    2011-04-01

    Full Text Available Esclerose múltipla é uma doença inflamatória desmielinizante, com presumida origem autoimune, que afeta o sistema nervoso central. A principal modalidade terapêutica é baseada no uso de imunomoduladores, como o interferon beta, que são geralmente bem tolerados. As manifestações cutâneas secundárias ao interferon beta-1b são representadas, na maioria das vezes, por reações no local de sua aplicação subcutânea. Descrevemos o caso de uma paciente do sexo feminino que desenvolveu um quadro de erupção acneiforme pelo interferon beta-1b.Multiple sclerosis is an inflammatory demyelinating disease of presumed autoimmune origin that affects the central nervous system. The main form of therapy is based on the use of immunomodulators such as interferon beta, which are usually well tolerated. Skin manifestations resulting from treatment with interferon beta-1b consist principally of reactions at the site of subcutaneous application of the drug. The present case report describes a female patient who developed an acneiform eruption resulting from treatment with interferon beta-1b.

  12. Primary and scattering contributions to beta scaled dose point kernels by means of Monte Carlo simulations; Contribuicoes primaria e espalhada para dosimetria beta calculadas pelo dose point kernels empregando simulacoes pelo Metodo Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Valente, Mauro [CONICET - Consejo Nacional de Investigaciones Cientificas y Tecnicas de La Republica Argentina (Conicet), Buenos Aires, AR (Brazil); Botta, Francesca; Pedroli, Guido [European Institute of Oncology, Milan (Italy). Medical Physics Department; Perez, Pedro, E-mail: valente@famaf.unc.edu.ar [Universidad Nacional de Cordoba, Cordoba (Argentina). Fac. de Matematica, Astronomia y Fisica (FaMAF)

    2012-07-01

    Beta-emitters have proved to be appropriate for radioimmunotherapy. The dosimetric characterization of each radionuclide has to be carefully investigated. One usual and practical dosimetric approach is the calculation of dose distribution from a unit point source emitting particles according to any radionuclide of interest, which is known as dose point kernel. Absorbed dose distributions are due to primary and radiation scattering contributions. This work presented a method capable of performing dose distributions for nuclear medicine dosimetry by means of Monte Carlo methods. Dedicated subroutines have been developed in order to separately compute primary and scattering contributions to the total absorbed dose, performing particle transport up to 1 keV or least. Preliminarily, the suitability of the calculation method has been satisfactory, being tested for monoenergetic sources, and it was further applied to the characterization of different beta-minus radionuclides of nuclear medicine interests for radioimmunotherapy. (author)

  13. Use of hydroxypropyl-beta-cyclodextrin ad polymer matrix for formation of inclusion complex with drug nifedipine; Uso da hidroxipropil-{beta}-ciclodextrina como matriz polimerica para formacao de complexo de inclusao como o farmaco nifedipina

    Energy Technology Data Exchange (ETDEWEB)

    Carneiro, Elisa F.; Araujo, Marcia V.G. de; Barbosa, Ronilson V.; Silva, Caroline W.P. da; Barisson, Andersson; Zawadzki, Sonia F., E-mail: zawadzki@quimica.ufpr.b [Universidade Federal do Parana (DQ/UFPR), Curitiba, PR (Brazil). Dept. de Quimica; Andrade, George Ricardo S. [Universidade Federal de Sergipe (UFS), Sao Cristovao, SE (Brazil). Nucleo de Ciencias e Engenharia dos Materiais; Costa Junior, Nivan B. da [Universidade Federal de Sergipe (DQ/UFS), Sao Cristovao, SE (Brazil). Dept. de Quimica

    2009-07-01

    In this work it was prepared and characterized an inclusion complex between the polymeric matrix hydroxypropyl-beta cyclodextrin and nifedipine, a hydrophobic drug calcium antagonistic, used for the cardiovascular diseases treatment. The study of the phase- solubility diagram showed an increase of the aqueous solubility of the drug after inclusion, was observed and The differential scanning calorimetry analysis did not show the melting point temperature of the drug in the formed complex. This fact is considered as an evidence of the encapsulation process. {sup 1}H NMR studies suggested that the non-aromatic ring of the nifedipine would be inserted in the cavity of the hydroxypropyl-beta-cyclodextrin.This orientation was also proposed by the used molecular modelling methods. (author)

  14. Primary 4{pi}{beta}-{gamma} coincidence system for standardization of radionuclides by means of plastic scintillators; Sistema primario por coincidencias 4{pi}{beta}-{gamma} para a padronizacao de radionuclideos empregando cintiladores plasticos

    Energy Technology Data Exchange (ETDEWEB)

    Baccarelli, Aida Maria

    2003-07-01

    The present work describes a 4{pi}({alpha},{beta})-{gamma} coincidence system for absolute measurement of radionuclide activity using a plastic scintillator in 4{pi} geometry for charged particles detection and a Nal (Tl) crystal for gamma-ray detection. Several shapes and dimensions of the plastic scintillator have been tried in order to obtain the best system configuration. Radionuclides which decay by alpha emission, {beta}{sup -}, {beta}{sup +} and electron capture have been standardized. The results showed excellent agreement with other conventional primary system which makes use of a 4{pi} proportional counter for X-ray and charged particle detection. The system developed in the present work have some advantages when compared with the conventional systems, namely; it does not need metal coating on the films used as radioactive source holders. When compared to liquid scintillators, is showed the advantage of not needing to be kept in dark for more than 24 h to allow phosphorescence decay of ambient light. Therefore it can be set to count immediately after the sources are placed inside of it. (author)

  15. Determination of total alpha and beta activity in water for human consumption by LSC(Liquid Scintillation Counter); Determinacao de atividades alfa e beta total em agua para consumo humano por LSC (Contador de Cintilacao Liquida))

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-01

    The Ordinance Brazilian of Ministry of Health (MS 2914/2011) establishes the standards for quality of water intended for human consumption, being limits values of 5.0 Bq/L for gross alpha, and 1.0 Bq/L for gross beta radioactivity. The liquid scintillation spectrometry (LSC) technique has been presented as an alternative to conventional procedure using gas flow proportional counter. The present work shows a review of the methods for determination of gross alpha and gross beta in water by using LSC. Between the factors that influence the accuracy and repeatability of the analytical results we can highlight: thermal preconcentration, type of the acid and calibration standard. A procedure was established and carried out to samples of the National Program of Intercomparison of Radionuclides in Environmental Samples for evaluation of its performance. The gross alpha and gross beta analysis in samples of the public water supplies in the Metropolitan Region of Goiania, state of Goias was carried out. The results are consistent with the guideline values form the Ministry of Health concerning radioactivity. (author)

  16. Calculation of the absorbed dose for contamination in skin imparted by beta radiation through the Varskin code modified for 122 isotopes of interest for nuclear medicine, nuclear plants and research; Calculo de dosis absorbida para contaminacion en piel impartida por radiacion beta mediante el codigo Varskin modificado para 122 isotopos de interes para medicina nuclear, plantas nucleares e investigacion

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, J.T

    1992-06-15

    In this work the implementation of a modification of the Varskin code for calculation of absorbed dose by contamination in skin imparted by external radiation fields generated by beta emitting is presented. The necessary data for the execution of the code are: isotope, dose depth, isotope activity, geometry type, source radio and time of integration of the isotope, being able to execute combinations of up to five radionuclides. This program it was implemented in Fortran 5 by means of the FFSKIN source program and the executable one in binary language BFFSKIN being the maximum execution time of 5 minutes. (Author)

  17. Synthesis of dimeric aryl{beta}-D-galactopyranosides for the evaluation of their interaction with the Erythrina cristagalli lectin; Sintese de {beta}-D-galactopiranosideos de arila dimericos para avaliacao de sua interacao com a lectina de Erythrina cristagalli

    Energy Technology Data Exchange (ETDEWEB)

    Figueiredo, Rute Cunha; Meyer, Nadia Burkowski; Prado, Maria Auxiliadora Fontes; Alves, Ricardo Jose [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Faculdade de Farmacia. Dept. de Produtos Farmaceuticos], e-mail: ricardodylan@farmacia.ufmg.br; Rojo, Javier [Consejo Superior de Investigaciones Cientificas (CSIC), Sevilla (Spain). Inst. de Investigaciones Quimicas. Grupo de Carbohidratos

    2009-07-01

    The synthesis of two new D-galactose-based dimers having a 1,4-butanediamine spacer is reported aiming at the evaluation of their interaction with the Erythrina cristagalli lectin. The title compounds were prepared in four and five steps from 2,3,4,6-tetra-O-acetyl-{beta}-D-galactopyranoside bromide, in 20 % and 15 % overall yield, respectively, using the Doebner modification of the Koenavenagel reaction as the key sep. The lectin-carbohydrate interaction could be evaluated for only one dimer, due to solubility problems. A twofold enhancement of affinity was observed, compared to the corresponding monovalent ligand. (author)

  18. Study of a 4{pi}{beta}-{gamma} coincidence system for absolute radionuclide activity measurement using plastic scintillators; Estudo de um sistema de coincidencias 4{pi}{beta}-{gamma} para a medida absoluta de atividade de radionuclideos empregando cintiladores plasticos

    Energy Technology Data Exchange (ETDEWEB)

    Piuvezam Filho, Helio

    2007-07-01

    The present work was intended to study a coincidence system 4{pi}(PS){beta}-{gamma} for absolute activity measurement using plastic scintillators in 4{pi} geometry. Along with experiments on the coincidence system, simulations were also performed applying the Monte Carlo Method, by means of codes PENELOPE and ESQUEMA. These simulations were performed in order to calculate the extrapolation curve of the coincidence system 4{pi}(PS){beta}-{gamma} and compare it to experimental data. A new geometry was proposed to the coincidence system adding up a second photomultiplier tube to the previous system for improving light collection from the plastic scintillator, as this system presented limitations in the minimum detected energy due to the presence of electronic noise and low gain. The results show that an improvement in the signal-to-noise ratio was obtained, as well as in the minimum detected energy. Moreover, there was an increase in the detection efficiency. With these modifications, it is now possible to calibrate radionuclides which emit low energy electrons or X-rays, increasing the number of radionuclides that can be standardized with this type of system.(author)

  19. Decay profiles of {beta} and {gamma} for a radionuclide inventory in equilibrium cycle of a BWR type reactor; Perfiles de decaimiento de radiacion {beta} y {gamma} para un inventario de radionuclidos en ciclo de equilibrio de un reactor tipo BWR

    Energy Technology Data Exchange (ETDEWEB)

    Salaices, M.; Sandoval, S.; Ovando, R. [Instituto de Investigaciones Electricas. Gerencia de Energia Nuclear, Av. Reforma 113 Col. Palmira. 62490 Cuernavaca, Morelos (Mexico)]. e-mail: sal@iie.org.mx

    2007-07-01

    Presently work the {beta} and {gamma} radiation decay profiles for a radionuclides inventory in equilibrium cycle of a BWR type reactor is presented. The profiles are presented in terms of decay in the activity of the total inventory as well as of the chemical groups that conform the inventory. In the obtaining of the radionuclides inventory in equilibrium cycle the ORIGEN2 code, version 1 was used, which simulates fuel burnup cycles and it calculates the evolution of the isotopic composition as a result of the burnt one, irradiation and decay of the nuclear fuel. It can be observed starting from the results that the decrease in the activity for the initial inventory and the different chemical groups that conform it is approximately proportional to the base 10 logarithm of the time for the first 24 hours of having concluded the burnt one. It can also be observed that the chemical groups that contribute in more proportion to the total activity of the inventory are the lanthanides-actinides and the transition metals, with 39% and 28%, respectively. The groups of alkaline earth metals, halogens, metalloids, noble gases and alkaline metals, contribute with percentages that go from the 8 to 5%. The groups that less they contribute to the total activity of the inventory they are the non metals and semi-metals with smaller proportions that 1%. The chemical groups that more contribute to the energy of {beta} and {gamma} radiation its are the transition metals and the lanthanides-actinides with a change in the order of importance at the end of the 24 hours period. The case of the halogens is of relevance for the case of the {gamma} radiation energy due that occupying the very near third site to the dimensions of the two previous groups. Additionally, the decay in the activity for the total inventory and the groups that conform it can be simulated by means of order 6 polynomials or smaller than describe its behavior appropriately. The results presented in this work, coupled

  20. A NIM (Nuclear Instrumentation Module) system conjugated with optional input for pHEMT amplifier for beta and gamma spectroscopy; Um sistema de modulos NIM conjugados com entrada opcional por amplificador pHEMT para espectroscopia beta e gama

    Energy Technology Data Exchange (ETDEWEB)

    Konrad, Barbara; Lüdke, Everton, E-mail: barbarakonradmev@gmail.com, E-mail: eludke@smail.ufsm.br [Universidade Federal de Santa Maria (LAE/UFSM), RS (Brazil). Lab. de Astrofisica e Eletronica

    2014-07-01

    This work presents a high speed NIM module (Nuclear Instrumentation Module) to detect radiation, gamma and muons, as part of a system for natural radiation monitoring and of extraterrestrial origin. The subsystem developed consists of a preamplifier and an integrated SCA (Single Channel Analyzer), including power supplies of ± 12 and ± 24V with derivations of +3.6 and ± 5V. The single channel analyzer board, consisting of discrete logic components, operating in window modes, normal and integral. The pulse shaping block is made up of two voltage comparators working at 120 MHz with a response time > 60 ns and a logic anticoincidence system. The preamplifier promotes a noise reduction and introduces the impedance matching between the output of anode / diode photomultiplier tubes (PMTs) and subsequent equipment, providing an input impedance of 1MΩ and output impedance of 40 to 140Ω. The shaper amplifier is non-inverting and has variable input capacitance of 1000 pF. The upper and lower thresholds of the SCA are adjustable from 0 to ± 10V, and the equipment is compatible with various types of detectors, like PMTs coupled to sodium iodide crystals. For use with liquid scintillators and photodiodes with crystals (CsI: Tl) is proposed to include a preamplifier circuit pHEMT (pseudomorphic High Electron Mobility Transistor) integrated. Yet, the system presents the possibility of applications for various purposes of gamma spectroscopy and automatic detection of events producing of beta particles.

  1. Beta vulgaris

    African Journals Online (AJOL)

    Heat treated Beetroot have the highest value for ABTS scavenging ability. ... powdered sample was stored in a clean dry plastic container at room ..... Nutritional value and economic feasibility of red beetroot. (Beta vulgaris L. ssp. vulgaris Rote Kugel) from different production systems. African Journal of. Agricultural ...

  2. Estimación del beta para el sector inmobiliario a partir del desempeño de fondos de inversión inmobiliaria en Colombia

    Directory of Open Access Journals (Sweden)

    Leonardo Santana Viloria

    2015-10-01

    Full Text Available La creación de fondos de inversión inmobiliaria en Colombia ha abiertoposibilidades de diversificación de portafolio a agentes que deseen invertir en el sector inmobiliario sin tener que comprar y administrar finca raíz de forma directa. El comportamiento de estos fondos ha mostrado una rentabilidad promedio superior y una volatilidad menor que la del mercado durante los últimos años. Este artículo aplica el modelo de valoración de activos de capital (CAPM y estima varios modelos autorregresivos y de heterocedasticidad condicional, con el fin de calcular el beta de estos fondos como una aproximación a la sensibilidad al riesgo sistemático del sector inmobiliario. Los resultados de las estimaciones muestran que el nivel de riesgo del sector inmobiliario se encuentra muy por debajo del riesgo de mercado, lo cual sugiere que los proyectos inmobiliarios tienen un costo de capital mucho menor que el de determinados proyectos en otros sectores.

  3. Characterization of ionizing radiation effects on human skin allografts; Caracterizacao dos efeitos da radiacao ionizante em pele humana para aloenxerto

    Energy Technology Data Exchange (ETDEWEB)

    Bourroul, Selma Cecilia

    2004-07-01

    The skin has a fundamental role in the viability of the human body. In the cases of extensive wounds, allograft skin provides an alternative to cover temporarily the damaged areas. After donor screening and preservation in glycerol (above 85%), the skin can be stored in the Skin Banks. The glycerol at this concentration has a bacteriostatic effect after certain time of preservation. On the other hand, skin sterilization by ionizing radiation may reduces the quarantine period for transplantation in patients and its safety is considered excellent. The objectives of this work were to establish procedures using two sources of ionizing radiation for sterilization of human skin allograft, and to evaluate the skin after gamma and electron beam irradiation. The analysis of stress-strain intended to verify possible effects of the radiation on the structure of preserved grafts. Skin samples were submitted to doses of 25 kGy and 50 kGy in an irradiator of {sup 60}Co and in an electron beam accelerator. Morphology and ultra-structure studies were also accomplished. The samples irradiated with a dose of 25 kGy seemed to maintain the bio mechanic characteristics. The gamma irradiated samples with a dose of 50 kGy and submitted to an electron beam at doses of 25 kGy and 50 kGy presented significant differences in the values of the elasticity modulus, in relation to the control. The analysis of the ultramicrographies revealed modifications in the structure and alterations in the pattern of collagen fibrils periodicity of the irradiated samples. (author)

  4. Radiation conditions for computerized tomography: determination and comparison; Condicoes de radiacao para tomografia computadorizada: determinacao e comparacoes

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Lucio das Chagas de

    2016-07-01

    Radiology is the practice in which radiation beams, usually radiation X are used to produce an image of the human body in order to obtain a diagnosis, for example, to evaluate a pathological condition by computerized tomography (CT). Although the computerized tomography diagnostic potential is unquestionable, caution must be taken because the doses are almost always higher than the observed in conventional radiology procedures. The ionization chamber used for dosimetry in CT is a unsealed cylindrical chamber with 10 cm and 15 cm of sensitive length. A typical characteristics of this camera is its uniform response to radiation incident at all angles around its axis. The revised edition of IEC 61267 (2005) brought as an innovation the radiation conditions for computed tomography, RQT, that simulate non-attenuated beam and are used in special CT applications. This study aims to establish the necessary conditions to obtain radiation pattern beam computed tomography, RQT, and a calibration laboratory implementation for pencil ionization chambers used in the beam dosimetry produced by these scanners in the Metrology National Laboratory of Ionizing Radiation (LNMRI). In the implementation of RQT conditions we were found that the ratio of kerma rates in the air, with or without additional filtration equivalent to the first HVL (half-value layer), are in accordance with IEC 61267 (2005), which provides a range between 48.5% and 51.5% for each quality. The LNMRI characterized the radiation conditions of RQT series (IEC, 2005), obtaining a percentage of 49.6% for the RQT 8, 50% for the RQT 9 and 50,4% for the RQT 10. With the substitution of the total additional filtration RQT qualities, composed by Al + Cu and by a total filtration composed by copper (Cu) only, it can be seen the emergence of a similar RQT quality named Quality Copper Tomography - QCT. The results of the calibration, the RQT and QCT qualities, had expanded uncertainties with a confidence level 95.45%, less then 4%. Studies of copper as attenuating material were very useful, making possible the implementation of QCT quality similar to RQT. Within results obtained for the equivalence curves between Al and Cu filtrations, it was found that copper could be used as material in the construction of the attenuation curve. (author)

  5. Ionizing radiation, nuclear energy and radiation protection for school; Radiacao ionizante, energia nuclear e protecao radiologica para a escola

    Energy Technology Data Exchange (ETDEWEB)

    Lucena, E.A.; Reis, R.G.; Pinho, A.S.; Alves, A.S.; Rio, M.A.P.; Reis, A.A., E-mail: arlene@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Silva, J.W.S. [Comissao Nacional de Energia Nuclear (CNEN), Rio de Janeiro, RJ (Brazil); Paula, G.A. de; Goncalves Junior, M.A. [Escola Sesc de Ensino Medio, Rio de Janeiro, RJ (Brazil)

    2017-04-01

    Since the discovery of X-rays in 1895, ionizing radiation has been applied in many sectors of society, such as medicine, industry, safety, construction, engineering and research. However, population is unaware of both the applications of ionizing radiation and their risks and benefits. It can be seen that most people associate the terms 'radiation' and 'nuclear energy' with the atomic bomb or cancer, most likely because of warlike applications and the stealthy way radioactivity had been treated in the past. Thus, it is necessary to clarify the population about the main aspects related to the applications, risks and associated benefits. These knowledge can be disseminated in schools. Brazilian legislation for basic education provides for topics such as nuclear energy and radioactivity to high school students. However, some factors hamper such an educational practice, namely, few hours of class, textbooks do not address the subject, previous concepts obtained in the media, difficulty in dealing with the subject in the classroom, phobia, etc. One solution would be the approximation between schools and institutions that employ technologies involving radioactivity, which would allow students to know the practices, associated radiological protection, as well as the risks and benefits to society. Currently, with the increasing application of ionizing radiation, especially in medicine, it is necessary to demystify the use of radioactivity. (author)

  6. Modeling and design of X-rays bidimensional detectors; Modelagem e projeto de detectores bidimensionais para radiacao-X

    Energy Technology Data Exchange (ETDEWEB)

    Quisbert, Elmer Paz Alcon

    2000-03-01

    In this work has been developed the scintillating fiber optic and semiconductor devices based 2-D detector design, modeling and performance evaluation using Monte Carlo methods, for high X-ray energy range (10-140 kV) radiography and tomography applications. These processes allowed us, also, the imaging system parameters and components optimization and appropriate detector design. The model estimated the detectors performance parameters (DQE, MTF and SNR), and radiation risk (in terms of mean absorbed dose in the patient) and to show up how the sequence of physical processes in X-ray detection influence the performance of this imaging PFOC detectors. In this way, the modeling of the detector includes the statistics of the spatial distribution of absorbed X-rays and of X-ray to light conversion, its transmission, and the light quanta conversion into electrons. Also contributions to noise from the detection system chain is included, mainly the CCD detector ambient noise. Performance prediction, based on calculation taken from simulations, illustrates how such detectors meet the exacting requirements of some medical and industrial applications. Also, it is envisaged that our modeling procedure of the imaging system will be suitable not only for investigating how the system components should be best designed but for CT and RD system performance prediction. The powerful techniques would enable us to give advice for future development, in this field, in search of more dose-efficient imaging systems. (author)

  7. National pattern for the realization of the unit of the dose speed absorbed in air for beta radiation. (Method: Ionometer, cavity of Bragg-Gray implemented in an extrapolation chamber with electrodes of variable separation, exposed to a field of beta radiation of {sup 90}Sr/{sup 90}Y); Patron Nacional para la realizacion de la unidad de la rapidez de dosis absorbida en aire para radiacion beta. (Metodo: Ionometrico, cavidad de Bragg-Gray implementada en una camara de extrapolacion con electrodos de separacion variable, expuesta a un campo de radiacion beta de {sup 90}Sr/{sup 90}Y)

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, M. T.; Morales P, J. R. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2001-01-15

    From the year of 1987 the Department of Metrology of the ININ, in their Secondary Laboratory of Calibration Dosimetric, has a patron group of sources of radiation beta and an extrapolation chamber of electrodes of variable separation.Their objective is to carry out of the unit of the dose speed absorbed in air for radiation beta. It uses the ionometric method, cavity Bragg-Gray in the extrapolation chamber with which it counts. The services that offers are: i) it Calibration : Radioactive Fuentes of radiation beta, isotopes: {sup 90}Sr/{sup 90}Y; Ophthalmic applicators {sup 9}0{sup S}r/{sup 90}Y; Instruments for detection of beta radiation with to the radiological protection: Ionization chambers, Geiger-Muller, etc.; Personal Dosemeters. ii) Irradiation with beta radiation of materials to the investigation. (Author)

  8. Measurement of extrapolation curves for the secondary pattern of beta radiation Nr. 86 calibrated in rapidity of absorbed dose for tissue equivalent by the Physikalisch Technische Bundesanstalt; Medicion de curvas de extrapolacion para el patron secundario de radiacion beta Nr. 86 calibrado en rapidez de dosis absorbida para tejido equivalente por el Physikalisch Technische Bundesanstalt

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, J.T

    1988-10-15

    The following report has as objective to present the obtained results of measuring - with a camera of extrapolation of variable electrodes (CE) - the dose speed absorbed in equivalent fabric given by the group of sources of the secondary pattern of radiation Beta Nr. 86, (PSB), and to compare this results with those presented by the calibration certificates that accompany the PSB extended by the primary laboratory Physikalisch Technische Bundesanstalt, (PTB), of the R.F.A. as well as the uncertainties associated to the measure process. (Author)

  9. Evaluación de la b-cipermetrina para el control de Triatoma infestans Evaluation of beta-cypermethrin for control of Triatoma infestans

    Directory of Open Access Journals (Sweden)

    Eduardo Nicolás Zerba

    1997-02-01

    Full Text Available En este estudio se evaluó en el laboratorio y en el campo el efecto insecticida sobre Triatoma infestans, vector de la enfermedad de Chagas, del nuevo piretroide ß-cipermetrina, y se comparó con el de la deltametrina. La comparación de las dosis letales 50 (DL50 de ambos piretroides indicó que la ß-cipermetrina es más efectiva en ninfas y la deltametrina, en adultos. La evaluación de la concentración letal 50 (CL50 de las dos formulaciones floables de ambos insecticidas depositados sobre distintos soportes mostró que su efectividad en vidrio es similar. En cerámica, la deltametrina es ligeramente más efectiva. Los dos insecticidas floables se evaluaron en 100 viviendas infestadas de la provincia de Santiago del Estero, Argentina. La deltametrina floable se aplicó a una concentración superficial de 25 mg/m² y la ß-cipermetrina, de 50 mg/m². Las concentraciones superficiales reales de ambos productos se analizaron por medio de papeles de filtro colocados en paredes y techos. El análisis por cromatografía de gases mostró buena coincidencia con las concentraciones previstas. Asimismo, se realizaron evaluaciones entomológicas 60, 90, 180 y 365 días después de los tratamientos. Solo en la última evaluación se encontró 10% de infestación en peridomicilios de viviendas tratadas con ß-cipermetrina y 7% en las viviendas tratadas con deltametrina (6% en el peridomicilio y 1% en el domicilio. Los resultados indican que la efectividad de la ß-cipermetrina para controlar a T. infestans cuando se aplica a una concentración de 50 mg/m² es similar a la de la deltametrina cuando esta se administra a una concentración de 25 mg/m².This study assessed the insecticidal effect in the laboratory and in the field of the new pyrethroid ß-cypermethrin against Triatoma infestans, the vector of Chagas' disease, and compared it with that of deltamethrin. Comparison of the 50% lethal dosis (LD50 of both pyrethroids showed that

  10. Métodos alternativos para detecção de betalactamase de espectro estendido em Escherichia coli e Klebsiella pneumoniae Alternative methods for the detection of extended-spectrum-beta-lactamase in Escherichia coli and Klebsiella pneumoniae

    Directory of Open Access Journals (Sweden)

    Alexsander Costa Martins

    2011-08-01

    Full Text Available INTRODUÇÃO: A resistência a antimicrobianos tem aumentado rapidamente nos últimos anos no Brasil e no mundo e, embora exista uma variedade de mecanismos de resistência, destaca-se a produção de betalactamase de espectro estendido (ESBL como um dos principais. Essas enzimas são mediadas por plasmídios, conferem resistência a vários antimicrobianos betalactâmicos e são inibidas por compostos, como ácido clavulânico, sulbactam e tazobactam. OBJETIVO: O objetivo deste estudo foi comparar metodologias alternativas à técnica padrão preconizada pelo Clinical and Laboratory Standards Institute (CLSI para detecção de ESBL. MATERIAL E MÉTODO: Foram realizados testes com 36 isolados (26 de E. coli e 10 de K. pneumoniae mediante disco combinado (CLSI e técnicas alternativas designadas meio disco (MD e substituição de discos (SD. CONCLUSÃO: As duas metodologias propostas apresentaram resultados satisfatórios com sensibilidade superior a 90% e custo inferior à técnica de referência (disco combinado, podendo ser utilizadas na pesquisa de ESBL.INTRODUCTION: Antimicrobial resistance has increased apace in Brazil and worldwide in the last years, even though there is a great variety of resistance mechanisms and extended spectrum beta-lactamases (ESBL is among the main ones. These enzymes are plasmid mediated, which causes resistance to some beta-lactam antimicrobials and are inhibited by compounds such as clavulanic acid, sulbactam and tazobactam. OBJECTIVE: The objective of this study was to compare alternative methods to the standard ESBL detection technique recommended by the Clinical and Laboratory Standards Institute (CLSI. MATERIAL AND METHOD: Tests with 36 isolates (26 E. coli and 10 K. pneumoniae were performed by means of CLSI disk diffusion method and alternative techniques designated as half disk (HD and disk substitution (SD. CONCLUSION: Both methods yielded satisfactory results with higher sensitivity (90% and lower costs

  11. Synthesis and characterization of nanostructured powders of hydroxyapatite and of three-calcium {beta} phosphate: elaboration of two phase compositions for application in the orthopedics and traumatology; Sintese e caracterizacao de pos nanoestruturados de hidroxiapatita e de fosfato tricalcico {beta}: elaboracao de composicoes bifasicas para aplicacoes na ortopedia e traumatologia

    Energy Technology Data Exchange (ETDEWEB)

    Dalmonico, G.M.L.; Pinheiro, D.M.; Camargo, N.H.A.; Orzechowki, L.G.; Goncalves, A.F.; Melnik, V.; Jesus, J.; Gemelli, E. [Universidade do Estado de Santa Catarina (UDESC), Joinville, SC (Brazil). Centro de Ciencias Tecnologicas], e-mail: gidalmonico@gmail.com

    2010-07-01

    This paper synthesized nano structured hydroxyapatite and three calcium {beta} phosphate, for elaboration of two phase compositions of HA/TCP in the concentration in volume of 80% HA/20% TCP-{beta}, 60% HA/40% TCP-{beta} and 50% HA/50% TCP-{beta}. For phase mixing realization, the method of mechanical fragmentation by attritor mill were used. The material recovered from the process of mechanical fragmentation was dried in rotate evaporator, supplying the two phase compositions. The preliminary studies shown the obtention of nano metric powders and a good phase dispersions inside the two phase compositions. (author)

  12. Beta Emission and Bremsstrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Karpius, Peter Joseph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-11-13

    Bremsstrahlung is continuous radiation produced by beta particles decelerating in matter; different beta emitters have different endpoint energies; high-energy betas interacting with high-Z materials will more likely produce bremsstrahlung; depending on the data, sometimes all you can say is that a beta emitter is present.

  13. Marcadores eletrocardiográficos para detecção precoce de doença cardíaca em pacientes com talassemia beta maior Electrocardiographic markers for the early detection of cardiac disease in patients with beta-thalassemia major

    Directory of Open Access Journals (Sweden)

    Kemal Nisli

    2010-04-01

    Full Text Available OBJETIVO: Analisar comparativamente a dispersão da onda P (DOP em pacientes com talassemia beta maior (β-TM e indivíduos saudáveis (controles para a detecção precoce do risco de arritmias. MÉTODOS: Oitenta e uma crianças com β-TM, com idades entre 4 e 19 anos, e 74 crianças saudáveis (grupo controle foram submetidas a exame eletrocardiográfico e ecocardiograma transtorácico de rotina para avaliação cardíaca. A DOP foi calculada como a diferença entre as durações máxima e mínima da onda P. RESULTADOS: Houve uma diferença estatisticamente significativa entre o grupo de estudo e o grupo controle no pico de velocidade do fluxo transmitral no início da diástole (E e na razão E/fluxo transmitral tardio (A. A duração máxima da onda P e a DOP foram significativamente maiores nos pacientes com β-TM do que nos indivíduos controles. CONCLUSÕES: O aumento da DOP em nossos pacientes com β-TM pode estar relacionado à depressão na condução intra-atrial, devido à dilatação atrial, e ao aumento da atividade simpática. Estes pacientes devem ser acompanhados atentamente devido à possibilidade de ocorrência de arritmias com risco de vida.OBJECTIVE: To comparatively evaluate P-wave dispersion (PWD in patients with β-thalassemia major (TM and healthy control subjects for the early prediction of arrhythmia risk. METHODS: Eighty-one children with β-TM, aged 4-19 years, and 74 healthy children (control group underwent routine electrocardiography and transthoracic echocardiography for cardiac evaluation. PWD was calculated as the difference between the maximum and the minimum P-wave duration. RESULTS: There was a statistically significant difference between study and control groups in peak early (E mitral inflow velocity and E/late (A velocity ratio. Maximum P-wave duration and PWD were found to be significantly higher in β-TM patients than in control subjects. CONCLUSIONS: Increased PWD in our β-TM patients might be related

  14. Forward-Looking Betas

    DEFF Research Database (Denmark)

    Christoffersen, Peter; Jacobs, Kris; Vainberg, Gregory

    -looking. This paper introduces a radically different approach to estimating market betas. Using the tools in Bakshi and Madan (2000) and Bakshi, Kapadia and Madan (2003) we employ the information embedded in the prices of individual stock options and index options to compute our forward-looking market beta......-looking betas contain information relevant for forecasting future betas that is not contained in historical betas....

  15. Epidemiologia das betalactamases de espectro estendido no Brasil: impacto clínico e implicações para o agronegócio Epidemiology of extended-spectrum beta-lactamases in Brazil: clinical impact and implications for agribusiness

    Directory of Open Access Journals (Sweden)

    Ketrin Cristina da Silva

    2012-04-01

    Full Text Available A emergência e a disseminação de bactérias produtoras de betalactamases de espectro estendido (ESBL têm sido retratadas como grande problema de saúde pública, especialmente no que diz respeito a patógenos associados às infecções relacionadas com a assistência à saúde (IRAS. No Brasil, a maior preocupação inclui as altas taxas de resistência a Klebsiella pneumoniae e Escherichia coli, embora as ESBL estejam amplamente disseminadas entre os membros da família Enterobacteriaceae e sejam descritas como enzimas do tipo TEM, SHV, CTX-M, VEB, BES e GES em diferentes estados. Contudo, as enzimas dos grupos CTX-M-2, CTX-M-8 e CTX-M-9 são as mais prevalentes em território brasileiro. Além do ambiente hospitalar, as ESBL de origem comunitária e ambiental têm sido retratadas. A CTX-M-2 também tem sido identificada em Salmonella, oriunda do ciclo de produção animal, o que é alarmante para o Brasil diante da importância que a exportação de carnes assume para o agronegócio. Dessa forma, faz-se necessária a regulamentação do uso de antimicrobianos em todos os setores, a fim de evitar a disseminação de bactérias resistentes e resguardar a qualidade e a inocuidade dos alimentos. Portanto, o presente estudo visa retratar o panorama geral da epidemiologia das ESBL no Brasil, enfatizando o impacto clínico, ambiental e econômico.The emergence and dissemination of extended-spectrum beta-lactamase bacteria (ESBL have been reported as a major public health issue, mainly with regard to nosocomial infections. In Brazil, ESBL are widely disseminated among the Enterobacteriaceae family and enzymes TEM, SHV, CTX-M, VEB, BES and GES have been reported in several states. However, the major concern is the high rates of resistant Klebsiella pneumoniae and Escherichia coli strains. Currently, ESBL belonging to CTX-M-2, CTX-M-8 and CTX-M-9 subtypes are the most prevalent in Brazil. Apart from nosocomial infections, ESBL bacteria from

  16. Procedure to carry out leakage test in beta radiation sealed sources emitters of {sup 90}Sr/{sup 90}Y; Procedimiento para realizar prueba de fuga en fuentes selladas de radiacion beta emisoras de {sup 90}Sr/{sup 90}Y

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, J. T., E-mail: trinidad.alvarez@inin.gob.m [ININ, Departamento de Metrologia de Radiaciones Ionizantes, Laboratorio Secundario de Calibracion Dosimetrica, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2010-09-15

    In the alpha-beta room of the Secondary Laboratory of Dosimetric Calibration of the Metrology Department of Ionizing Radiations ophthalmic applicators are calibrated in absorbed dose terms in water D{sub w}; these applicators, basically are emitter sealed sources of pure beta radiation of {sup 90}Sr / {sup 90}Y. Concretely, the laboratory quality system indicates to use the established procedure for the calibration of these sources, which establishes the requirement of to carry out a leakage test, before to calibrate the source. However, in the Laboratory leakage test certificates sent by specialized companies in radiological protection services have been received, in which are used gamma spectrometry equipment s for beta radiation leakage tests, since it is not reliable to detect pure beta radiation with a scintillating detector with NaI crystal, (because it could detect the braking radiation produced in the detector). Therefore the Laboratory has had to verify the results of the tests with a correct technique, with the purpose of determining the presence of sources with their altered integrity and radioactive material leakage. The objective of this work is to describe a technique for beta activity measurement - of the standard ISO 7503, part 1 (1988) - and its application with a detector Gm plane (type pankage) in the realization of leakage tests in emitter sources of pure beta radiation, inside the mark of quality assurance indicated by the report ICRU 76. (Author)

  17. Realized Beta GARCH

    DEFF Research Database (Denmark)

    Hansen, Peter Reinhard; Lunde, Asger; Voev, Valeri Radkov

    2014-01-01

    as the beta. We apply the model to a large set of assets and find the conditional betas to be far more variable than usually found with rolling-window regressions based exclusively on daily returns. In the empirical part of the paper, we examine the cross-sectional as well as the time variation...... of the conditional beta series during the financial crises....

  18. Roughing up Beta

    DEFF Research Database (Denmark)

    Bollerslev, Tim; Li, Sophia Zhengzi; Todorov, Viktor

    -section. An investment strategy that goes long stocks with high jump betas and short stocks with low jump betas produces significant average excess returns. These higher risk premiums for the discontinuous and overnight market betas remain significant after controlling for a long list of other firm characteristics......-section of expected returns. Based on a novel highfrequency dataset of almost one-thousand individual stocks over two decades, we find that the two rough betas associated with intraday discontinuous and overnight returns entail significant risk premiums, while the intraday continuous beta is not priced in the cross...... and explanatory variables previously associated with the cross-section of expected stock returns....

  19. Pesquisa de marcadores para os genes da cadeia pesada da beta-miosina cardíaca e da proteína C de ligação à miosina em familiares de pacientes com cardiomiopatia hipertrófica Research of markers for the genes of the heavy chain of cardiac beta-myosin and myosin binding protein C in relatives of patients with hypertrophic cardiomyopathy

    Directory of Open Access Journals (Sweden)

    Adriana Paula Tirone

    2005-06-01

    Full Text Available OBJETIVO: Estudar os marcadores moleculares para os genes da cadeia pesada da beta-miosina cardíaca e da proteína-C de ligação à miosina em familiares de portadores de cardiomiopatia hipertrófica. MÉTODOS: Foram estudadas 12 famílias que realizaram anamnese, exame físico, eletrocardiograma, ecocardiograma e coleta de sangue para o estudo genético através da reação em cadeia da polimerasse. RESULTADOS: Dos 227 familiares 25% eram acometidos, sendo 51% do sexo masculino com idade média de 35±19 (2 a 95 anos. A análise genética mostrou ligação com o gene da b-miosina cardíaca em uma família e, em outra, ligação com o gene da proteína C de ligação à miosina. Em cinco famílias foram excluídas ligações com os dois genes; em duas, a ligação com o gene da proteína C de ligação à miosina, porém para o gene da b-miosina os resultados foram inconclusivos; em duas famílias os resultados foram inconclusivos para os dois genes e em uma foi excluída ligação para o gene da b-miosina mas ficou inconclusivo para o gene da proteína C de ligação à miosina. CONCLUSÃO: Em nosso meio, talvez predominem outros genes que não aqueles descritos na literatura, ou que existam outras diferenças genéticas relacionadas com a origem de nossa população e/ou fatores ambientais.OBJECTIVE: To study the molecular markers for the genes of the heavy chain of cardiac beta-myosin and the myosin binding protein C in relatives of carriers of hypertrophic cardiomyopathy. METHODS: Twelve families who had anamnesis, physical exam, electrocardiogram, echocardiogram and blood collection for the genetic study through the chain reaction of polymerase. RESULTS: From the 227 relatives, 25% were ill-taken, with 51% men, with an average age of 35±19 (2 to 95 years old. The genetic analysis showed a connection with the gene of the cardiac b-myosin in a family and, in another, a connection with the gene of the myosin-binding protein C. In five

  20. Betting Against Beta

    DEFF Research Database (Denmark)

    Frazzini, Andrea; Heje Pedersen, Lasse

    We present a model with leverage and margin constraints that vary across investors and time. We find evidence consistent with each of the model’s five central predictions: (1) Since constrained investors bid up high-beta assets, high beta is associated with low alpha, as we find empirically for U.......S. equities, 20 international equity markets, Treasury bonds, corporate bonds, and futures; (2) A betting-against-beta (BAB) factor, which is long leveraged low beta assets and short high-beta assets, produces significant positive risk-adjusted returns; (3) When funding constraints tighten, the return...... of the BAB factor is low; (4) Increased funding liquidity risk compresses betas toward one; (5) More constrained investors hold riskier assets....

  1. Betting against Beta

    DEFF Research Database (Denmark)

    Frazzini, Andrea; Heje Pedersen, Lasse

    2014-01-01

    We present a model with leverage and margin constraints that vary across investors and time. We find evidence consistent with each of the model's five central predictions: (1) Because constrained investors bid up high-beta assets, high beta is associated with low alpha, as we find empirically...... for US equities, 20 international equity markets, Treasury bonds, corporate bonds, and futures. (2) A betting against beta (BAB) factor, which is long leveraged low-beta assets and short high-beta assets, produces significant positive risk-adjusted returns. (3) When funding constraints tighten......, the return of the BAB factor is low. (4) Increased funding liquidity risk compresses betas toward one. (5) More constrained investors hold riskier assets....

  2. Beta-Ketothiolase Deficiency

    Directory of Open Access Journals (Sweden)

    Elsayed Abdelkreem MD, MSc

    2016-03-01

    Full Text Available Beta-ketothiolase deficiency is an inherited disorder of ketone body metabolism and isoleucine catabolism. It typically manifests as recurrent ketoacidotic episodes with characteristic abnormalities in the urinary organic acid profile. However, several challenges in the diagnosis of beta-ketothiolase deficiency have been encountered: atypical presentations have been reported and some other disorders, such as succinyl-CoA:3-oxoacid CoA transferase and 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiencies, can mimic the clinical and/or biochemical signs of beta-ketothiolase deficiency. A final diagnosis of beta-ketothiolase deficiency requires an enzymatic assay and/or a molecular analysis, but some caveats must be considered. Despite the reported missed cases, screening programs have successfully identified an increasing number of patients with beta-ketothiolase deficiency. Early diagnosis and management of beta-ketothiolase deficiency will enable prevention of its serious acute and chronic complications and ultimately improve the prognosis.

  3. Guide for the estimation of the {alpha} and {beta} coefficients in the Average enrichment equation as burnt function by fuel type; Guia para la estimacion de los coeficientes {alpha} y {beta} en la ecuacion de enriquecimiento promedio como funcion del quemado por tipo de combustible

    Energy Technology Data Exchange (ETDEWEB)

    Montes T, J.L.; Cortes C, C.C. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1992-08-15

    The objective of the report is to determine manually or by means of a calculation sheet, the coefficients {alpha} and {beta} of the average enrichment equation as function of the fuel burnt (B) using the Lineal Reactivity Pattern, with information generated by the RECORD code of the FMS package. (Author00.

  4. Beta-Carotene

    Science.gov (United States)

    ... to long-term liver disease, a disease called amyotrophic lateral sclerosis (ALS), and the enlargement of a blood vessel ... of beta-carotene daily doesnt have any benefit. Amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease). Taking beta-carotene supplements ...

  5. Neutrinoless double beta decay

    Indian Academy of Sciences (India)

    2012-10-06

    Oct 6, 2012 ... The physics potential of neutrinoless double beta decay is discussed. Furthermore, experimental considerations as well as the current status of experiments are presented. Finally, an outlook towards the future, work on nuclear matrix elements and alternative processes is given. Keywords. Double beta ...

  6. Rapid synthesis of beta zeolites

    Science.gov (United States)

    Fan, Wei; Chang, Chun -Chih; Dornath, Paul; Wang, Zhuopeng

    2015-08-18

    The invention provides methods for rapidly synthesizing heteroatom containing zeolites including Sn-Beta, Si-Beta, Ti-Beta, Zr-Beta and Fe-Beta. The methods for synthesizing heteroatom zeolites include using well-crystalline zeolite crystals as seeds and using a fluoride-free, caustic medium in a seeded dry-gel conversion method. The Beta zeolite catalysts made by the methods of the invention catalyze both isomerization and dehydration reactions.

  7. Expresión diferencial en placenta de beta-defensinas humanas y detección de variantes alélicas en el gen DEFB1 de madres positivas para VIH-1

    Directory of Open Access Journals (Sweden)

    Wbeimar Aguilar-Jiménez

    2011-04-01

    Conclusión. Los resultados contrastantes de los niveles de HBD se deben, probablemente, a estímulos virales y sugieren que el VIH-1 induce una expresión diferencial de beta-defensinas humanas en placenta y que estas proteínas podrían estar involucradas en la protección contra el VIH-1, al menos, en las etapas tempranas del embarazo. Sin embargo, no fue posible asociar estos hallazgos con la protección contra la transmisión vertical del VIH-1, puesto que ninguno de los bebés adquirió la infección.

  8. Indicación de antibióticos en niños con faringoamigdalitis aguda y test positivo para estreptococo beta hemolítico del grupo A atendidos en el Instituto Nacional de Salud del Niño, Lima – Perú

    OpenAIRE

    Ubillús, Gloria; Universidad de San Martin de Porres; Patiño, Lilian; Maza, Giovanna; Vicuña, Raúl; Pregúntegui, Ivethe; Reyes, Patricia Reyes; Ríos, Carol; Lancho, Luciana

    2013-01-01

    OBJETIVOConocer la frecuencia de la indicación de antibióticos en niños con diagnóstico clínico de faringoamigdalitis aguda (FAA) y test rápido positivo para estreptococo beta hemolítico del grupo A atendidos en consultorios externos de Pediatría, y el tipo de antibiótico indicado con más frecuencia.MATERIAL Y MÉTODOEstudio descriptivo, transversal. La muestra fue de 351 niños de 3 a 15 años diagnosticados como FAA. Abordados a la salida de la consulta y con firma del consentimiento informado ...

  9. Avaliação do método de espectrometria por cintilação em meio líquido para a medida das atividades alfa e beta total em água: aplicação a águas de abastecimento público no estado de Goiás, Brasil

    Directory of Open Access Journals (Sweden)

    Raquel Maia Mingote

    Full Text Available RESUMO Uma revisão da determinação de alfa e beta total em água, usando espectrometria de cintilação em meio líquido, é apresentada. Foram identificados os principais fatores que influenciam a exatidão e a repetibilidade dos resultados analíticos: pré-concentração térmica, tipo de ácido, janela de contagem e padrão de calibração. Um procedimento analítico foi estabelecido e aplicado a amostras de água de abastecimento público do estado de Goiás para avaliação das radioatividades alfa e beta total. O resumo estatístico dos dados foi realizado por meio dos métodos de análise de dados censurados. Os resultados estão consistentes com os valores de referência do Ministério da Saúde.

  10. Beta Thalassemia (For Parents)

    Science.gov (United States)

    ... anemia or failure to thrive. If the doctor suspects beta thalassemia, he or she will take a ... test called a hemoglobin electrophoresis and/or a DNA test for abnormal hemoglobin genes. If both parents ...

  11. High beta multipoles

    Energy Technology Data Exchange (ETDEWEB)

    Prager, S C

    1982-05-01

    Multipoles are being employed as devices to study fusion issues and plasma phenomena at high values of beta (plasma pressure/magnetic pressure) in a controlled manner. Due to their large volume, low magnetic field (low synchrotron radiation) region, they are also under consideration as potential steady state advanced fuel (low neutron yield) reactors. Present experiments are investigating neoclassical (bootstrap and Pfirsch-Schlueter) currents and plasma stability at extremely high beta.

  12. Beta-thalassemia

    OpenAIRE

    Origa Raffaella; Galanello Renzo

    2010-01-01

    Abstract Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The total annual incidence of symptomatic individuals is estimated at 1 in 100,000 throughout the world and 1 in 10,000 people in the European Union. Three main forms have been described: thalassemia major, thalassemia intermedia and thalassemia minor...

  13. {beta} - amyloid imaging probes

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Jae Min [Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2007-04-15

    Imaging distribution of {beta} - amyloid plaques in Alzheimer's disease is very important for early and accurate diagnosis. Early trial of the {beta} -amyloid plaques includes using radiolabeled peptides which can be only applied for peripheral {beta} - amyloid plaques due to limited penetration through the blood brain barrier (BBB). Congo red or Chrysamine G derivatives were labeled with Tc-99m for imaging {beta} - amyloid plaques of Alzheimer patient's brain without success due to problem with BBB penetration. Thioflavin T derivatives gave breakthrough for {beta} - amyloid imaging in vivo, and a benzothiazole derivative [C-11]6-OH-BTA-1 brought a great success. Many other benzothiazole, benzoxazole, benzofuran, imidazopyridine, and styrylbenzene derivatives have been labeled with F-18 and I-123 to improve the imaging quality. However, [C-11]6-OH-BTA-1 still remains as the best. However, short half-life of C-11 is a limitation of wide distribution of this agent. So, it is still required to develop an Tc-99m, F-18 or I-123 labeled agent for {beta} - amyloid imaging agent.

  14. Gamma radiation effect on agar viscosity for use in food industry; Efeito da radiacao gama na viscosidade de agar para uso na industria alimenticia

    Energy Technology Data Exchange (ETDEWEB)

    Aliste, Antonio J.; Del Mastro, Nelida L. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)

    1999-11-01

    The application of food radiation processing is increasing worldwide mainly because of its efficiency in the industrial decontamination of packaged food products. Indeed, the process neither introduces any undesirable elements nor increases the temperature, thus allowing the preparation of ready-to-use products which remain stable for long periods at room temperature. The aim of this work was to study the effect of Co-60 gamma radiation on the viscosity of agar. This hydrocolloid derived from seaweed is a galactose polymer with a high hysteresis capacity (great difference among melting and gelification temperature) which is extremely important when used as additive for the food industry. Commercial agar was irradiated with doses of 0, 1, 5 and 10 kGy. Proper dilutions were prepared and the viscosity was measured in a Brookfield model LVDVIII viscosimeters. The relationships viscosity/dose for the temperatures of 45 deg C and 60 deg C were established. The decrease of the viscosity was 71.4% and 49.6% respectively when the applied dose was 10 kGy. The implications of the use of this additive in food irradiation are discussed. (author) 9 refs., 2 figs.

  15. Analysis of ferritic stainless steel tube applied in radiation furnaces; Analise de tubos de aco inoxidavel ferritico para aplicacao em fornos de radiacao

    Energy Technology Data Exchange (ETDEWEB)

    Porto, P.C.R.; Spim, J.A. [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil). Centro de Tecnologia. Lab. de Fundicao], e-mail: spim@ufrgs.br; Santos, C.A. [Pontificia Universidade Catolica do Rio Grande do Sul (PUC-RS), Porto Alegre, RS (Brazil). Fac. de Engenharia. Programa de Pos-Graduacao em Engenharia e Tecnologia de Materiais (PGETEMA)

    2006-07-01

    The objective of this work was to evaluate the change in mechanic properties and phase transformations of ferritic stainless steel tube, ASTM 268 Gr 446, applied in high temperature conditions. The work has used tubes from radiation furnaces of the PETROBRAS Xisto Industrialization Unit. The samples used for comparison were obtained from new tubes and tubes already used in furnaces. The test analyses were optical metallography, scanning electron microscopy, energy dispersive spectrometer, hardness and microhardness test and tension test. Results have shown that the new tubes presented a ferritic matrix and in old tubes were observed a great quantity of sigma phase and carbides. Along with the thickness of the tubes it was verified that the inside region presented an increase of sulfate and the outside region an increase of carbides. (author)

  16. Preliminary results in the development of system for remote mapping of radiation; Resultados preliminares no desenvolvimento de sistema para mapeamento remoto de radiacao

    Energy Technology Data Exchange (ETDEWEB)

    Jesus, Miller F. de; Carvalho, Paulo Victor R. de; Farias, Marcos S., E-mail: mil-far@hotmail.com, E-mail: paulov@ien.gov.br, E-mail: msantana@ien.gov.br [Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil). Div. de Engenharia Nuclear

    2013-07-01

    This paper presents a project that aims to use virtual instrumentation on mobile devices to carry out radiation monitoring in an environment using mobile robots. The idea is to use this development to reduce the need for exposed workers at nuclear facilities. The design is based on a mobile robot that is controlled by commands sent via network wireless. The robot is coupled to the body a radiation monitor that is designed to send the radiation in the environment data rate also through the wireless network. The system is completed by programs developed for controlling the robot and receiving the radiation rate measurements, enabling remote and mobile monitoring of radiation and automating the mapping of radiation in the environment.

  17. Study of radiation conditions for obtaining standard beam computed tomography; Estudo das condicoes de radiacao para obtencao do feixe padrao em tomografia computadorizada

    Energy Technology Data Exchange (ETDEWEB)

    Andrade, Lucio das Chagas de; Peixoto, Jose Guilherme Pereira, E-mail: lucio-andrade@hotmail.com [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2015-07-01

    In Brazil there is a need to expand the traceability for the calibration of cameras used in dosimetry in CT. Thus, in order to promote the expansion of the radiation conditions RQT, LNMRI disseminate this greatness. These radiation conditions may be characterized in terms of tension in the X-ray tube (PPV), the first half-value layer (1{sup st} HVL) and homogeneity coefficient (CH). The LNMRI achieved satisfactory results within the international specifications suggested by IEC 61267 and TRS 457. (author)

  18. Characterization of chemical compounds for dosimetry of the radiation in industrial processes; Caracterizacao de compostos quimicos para dosimetria das radiacaoes em processos industriais

    Energy Technology Data Exchange (ETDEWEB)

    Galante, Ana Maria Sisti

    1999-07-01

    Different chemical compounds have been studied to optimize dosimetric systems in irradiation processes. In this study 2,3,5 Triphenyl -2H- Tetrazolium Chloride, Brilliant Cresyl Blue, Bromocresol Green and Potassium Nitrate were investigated for their merits or faults, for {sup 60} Co gamma field, in order to verify if can be considered as dosimeters. Fricke solution was used as reference dosimeter to determine absorption dose rates at the gamma facilities.Only Bromocresol Green and Potassium Nitrate are recommended for dosimetry purposes since the main characteristics were achieved. The other two compounds could be used in dosimetry with changes in their formulation. Bromocresol Green and potassium Nitrate are reproducible and radiation sensitive for absorbed doses from 300 Gy to 150 kGy Bromocresol Green was used in liquid form and Potassium Nitrate was prepared in solid pellets form. Spectrophotometry in the visible region was used as the main detection technique, which allows relating optical absorption, before and after irradiation, with the absorbed dose. The maximum absorption wavelength for each compound was observed at 450-460nm for bromocresol Green and 546nm for Potassium Nitrate. Dose calibration curves are linear for both compounds in all dose intervals. When irradiated with accelerated electrons, with energies between o,9 MeV and 1,5MeV, optical absorption intensification, of about 2,6 times, was observed when comparing results for Potassium Nitrate, with those for gamma rays. All the evaluations are presented in this work. (author)

  19. Development of crystals based in cesium iodide for application as radiation detectors; Desenvolvimento de cristais baseados em iodeto de cesio para aplicacao como detectores de radiacao

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Maria da Conceicao Costa

    2006-07-01

    Inorganic scintillators with fast luminescence decay time, high density and high light output have been the object of studies for application in nuclear physics, high energy physics, nuclear tomography and other fields of science and engineering. Scintillation crystals based on cesium iodide (CsI) are matters with relatively low higroscopy, high atomic number, easy handling and low cost, characteristics that favor their use as radiation detectors. In this work, the growth of pure CsI crystals, CsI:Br and CsI:Pb, using the Bridgman technique, is described. The concentration of the bromine doping element (Br) was studied in the range of 1,5x10{sup -1} M to 10{sup -2} M and the lead (Pb) in the range of 10{sup -2} M to 5x10{sup -4} M. To evaluate the scintillators developed, systematic measurements were carried out for luminescence emission and luminescence decay time for gamma radiation, optical transmittance assays, Vickers micro-hardness assays, determination of the doping elements distribution along the grown crystals and analysis of crystals response to the gamma radiation in the energy range of 350 keV to 1330 keV and alpha particles from a {sup 241}Am source, with energy of 5.54 MeV. It was obtained 13 ns to 19 ns for luminescence decay time for CsI:Br and CsI:Pb crystals. These results were very promising. The results obtained for micro-hardness showed a significant increase in function of the doping elements concentration, when compared to the pure CsI crystal, increasing consequently the mechanical resistance of the grown crystals. The validity of using these crystals as radiation sensors may be seen from the results of their response to gamma radiation and alpha particles. (author)

  20. Development of capacity for measuring ionizing radiation in aircraft crew; Desenvolvimento da capacitacao para efetuar medicoes de radiacao ionizante em tripulacoes de aeronaves

    Energy Technology Data Exchange (ETDEWEB)

    Federico, C.A.; Goncalez, O.L., E-mail: claudiofederico@ieav.cta.b, E-mail: odairl@ieav.cta.b [Centro Tecnico Aeroespacial (CTA/ITA), Sao Jose dos Campos, SP (Brazil). Inst. Tecnologico de Aeronautica; Caldas, L.V.E., E-mail: lcaldas@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-10-26

    This paper describes the activities performed in a research program of the Institute of Advanced Studies, Brazil, belonging to the Brazilian Air Force, joining to researches from Brazilian Nuclear Energy Commission, in order to bring to Brazil the capacity and acknowledge necessary to the evaluation of dose from ionizing radiation originated in the cosmic radiation and its by products which fall on aircraft crews

  1. Evaluation of attenuating materials: model for the distribution of scattered radiation; Avaliacao de materiais atenuadores: modelo para a distribuicao da radiacao espalhada

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Paulo R. [Sao Paulo Univ., SP (Brazil). Inst. de Energia e Eletrotecnica; Caldas, Linda V.E. [Instituto de Pesquisas Energeticas e Nucleares (IPEN), Sao Paulo, SP (Brazil)

    1996-12-31

    A mathematical model for the behaviour of the distribution of photon scattered by attenuating media is presented. Shielding barriers or attenuating materials used in tests of quality control in radiology are proposed. Comparative results for Lucite are reported 6 refs., 2 figs.

  2. Beta and Gamma Gradients

    DEFF Research Database (Denmark)

    Løvborg, Leif; Gaffney, C. F.; Clark, P. A.

    1985-01-01

    Experimental and/or theoretical estimates are presented concerning, (i) attenuation within the sample of beta and gamma radiation from the soil, (ii) the gamma dose within the sample due to its own radioactivity, and (iii) the soil gamma dose in the proximity of boundaries between regions...... of differing radioactivity. It is confirmed that removal of the outer 2 mm of sample is adequate to remove influence from soil beta dose and estimates are made of the error introduced by non-removal. Other evaluations include variation of the soil gamma dose near the ground surface and it appears...

  3. Comparación de cuatro métodos fenotípicos para la detección de beta-lactamasas de espectro extendido Comparison of four phenotypic methods to detect extended-spectrum betalactamases

    Directory of Open Access Journals (Sweden)

    Lizet Lezameta

    2010-09-01

    Full Text Available Objetivo. Comparar la eficacia de cuatro métodos fenotípicos para la identificación de cepas productoras de β-lactamasas de espectro extendido aisladas de urocultivos. Materiales y métodos. Estudio comparativo de corte transversal. Se analizó 147 cepas aisladas de urocultivos positivos para Escherichia coli, Klebsiella pneumoniae y Proteus mirabilis entre los meses de enero y febrero de 2009 en el Instituto Nacional de Salud del Niño, las cuales fueron sometidas a una prueba de tamizaje, en aquellas que resultaron positivas se realizó pruebas confirmatorias mediante los cuatro métodos fenotípicos evaluados. Resultados. De las 147 cepas, 43 (29,3% resultaron sospechosas en las pruebas de tamizaje. Con el método descrito por Clinical and Laboratory Standards Institute (CLSI usado como "patrón de oro" para el estudio, resultaron 27 positivas (62,8%, resultado similar a lo encontrado con el método de Jarlier. Por otro lado, con los métodos de Hodge y el tridimensional, 23 (53,5% resultaron positivas. La evaluación de los métodos confirmatorios frente al descrito por CLSI, mostró una sensibilidad y especificidad de 100% para el método de Jarlier; en el caso de los métodos de Hodge y método tridimensional se encontró una sensibilidad y especificidad de 85,2 % y 100%, respectivamente. Conclusiones. Los métodos evaluados mostraron en todos los casos una alta eficacia, sin presentar diferencias significativas, por lo que podrían utilizarse según las facilidades del laboratorio clínico involucrado; sin embargo dada las ventajas no técnicas, como costos, facilidad y factibilidad de su aplicación, se recomienda el empleo del método de Jarlier.Objective. To compare the efficacy of four phenotypic methods for the identification of strains producing extendedspectrum β-lactamases isolated from urine cultures. Materials and methods. Comparative cross-sectional study. 147 strains isolated from positive urine cultures for Escherichia

  4. Guías para el uso racional de antibióticos beta-lactámicos: mecanismos de resistencia y su interpretación clínica.

    Directory of Open Access Journals (Sweden)

    César A. Arias

    2003-06-01

    Full Text Available Los antibióticos ß-lactámicos son los compuestos más ampliamente usados para tratar infecciones adquiridas en el hospital o en la comunidad. Sin embargo, la resistencia a estos antibióticos en bacterias Gram negativas y Gram positivas se ha incrementado, lo cual limita su eficacia terapéutica. Se debe estar alerta a este fenómeno y seleccionar la terapia de acuerdo con el mecanismo de resistencia probable del germen aislado. La lectura interpretativa de los patrones de susceptibilidad permite un enfoque más racional del problema de resistencia y se convierte en una guía fundamental para el manejo de situaciones específicas. Dada la complejidad de los mecanismos de resistencia, es indispensable que el laboratorio identifique los microorganismos según especie y determine la susceptibilidad de un número razonable de antimicrobianos. La resistencia a ß-lactámicos en Enterobacteriaceae se debe principalmente a la producción de ß-lactamasas codificadas cromosómicamente o en plásmidos. Los mecanismos de impermeabilidad y la producción de bombas de exclusión molecular son los más comunes en microorganismos 'no fermentadores', por lo cual la terapia debe responder a estos fenómenos. En bacterias Gram positivas existen varios mecanismos involucrados: producción de proteínas de unión a penicilina (PBP alteradas, síntesis de nuevas PBP o producción de ß-lactamasas. Se discuten aquí las opciones terapéuticas basadas en el conocimiento de los mecanismos de resistencia.

  5. Trichoderma .beta.-glucosidase

    Science.gov (United States)

    Dunn-Coleman, Nigel; Goedegebuur, Frits; Ward, Michael; Yao, Jian

    2006-01-03

    The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl3, and the corresponding BGL3 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL3, recombinant BGL3 proteins and methods for producing the same.

  6. Beta thalassemia - a review

    Directory of Open Access Journals (Sweden)

    R Jha

    2014-09-01

    Full Text Available Thalassemia is a globin gene disorder that results in a diminished rate of synthesis of one or more of the globin chains. About 1.5% of the global population (80 to 90 million people are carriers of beta Thalassemia. More than 200 mutations are described in beta thalassemia. However not all mutations are common in different ethnic groups. The only effective way to reduce burden of thalassemia is to prevent birth of homozygotes. Diagnosis of beta thalassemia can be done by fetal DNA analysis for molecular defects of beta thalassemia or by fetal blood analysis. Hematopoietic stem cell transplantation is the only available curative approach for Thalassemia. Many patients with thalassemia in underdeveloped nations die in childhood or adolescence. Programs that provide acceptable care, including transfusion of safe blood and supportive therapy including chelation must be established.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11609 Journal of Pathology of Nepal; Vol.4,No. 8 (2014 663-671

  7. beta nur pratiwi

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics. BETA NUR PRATIWI. Articles written in Pramana – Journal of Physics. Volume 88 Issue 2 February 2017 pp 25 Regular. Asymptotic iteration method for the modified Pöschl–Teller potential and trigonometric Scarf II non-central potential in the Dirac equation spin symmetry.

  8. Neutrinoless double beta decay

    Indian Academy of Sciences (India)

    2015-11-27

    Nov 27, 2015 ... Abstract. The physics potential of neutrinoless double beta decay is discussed. Furthermore, experimental considerations as well as the current status of experiments are presented. Finally, an outlook towards the future, work on nuclear matrix elements and alternative processes is given.

  9. Double beta decay

    Energy Technology Data Exchange (ETDEWEB)

    Bryman, D.; Picciotto, C.

    1978-01-01

    The problem of double beta decay is reviewed with emphasis on its relevance to lepton number conservation. Recently, the ratio of the double beta-decay half-lives of /sup 128/Te and /sup 130/Te has been measured in a geological experiment and a limit for the ratio of the neutrinoless rate to the total rate for /sup 82/Se decay has been obtained from a direct-detection experiment. For the first time, these results show conclusively that double beta decay is not primarily a lepton-number-violating neutrinoless process. However, they also do not agree with calculations which assume that only lepton-number-conserving two-neutrino double beta decay occurs. The conclusion that lepton number conservation is violated is suggested by limited experimental information. By considering contributions to the total rate from both the two-neutrino and the neutrinoless channels, we obtain data which are consistent with a lepton nonconservation parameter of order eta=3.5 x 10/sup -5/. Roughly the same value of eta is obtained by assuming that the decay occurs either via lepton emission from two nucleons or via emission from a resonance in the nucleus.

  10. Beta Cell Breakthroughs

    Science.gov (United States)

    ... raise the hopes of people with type 1 diabetes that a cure is right around the corner. First the beta ... element: Two of his children have type 1 diabetes. After his son was diagnosed with the disease as an infant, Melton devoted his career to searching for a cure. More than 20 years have gone by, but ...

  11. Beta limits for torsatrons

    Science.gov (United States)

    Bauer, F.; Betancourt, O.; Garabedian, P.; Shohet, J. L.

    1981-01-01

    An ideal magnetohydrodynamic equilibrium and stability code is used to study ballooning modes in torsatrons. The most dangerous modes turn out to be those with low poloidal and toroidal wave numbers. Beta limits for equilibrium and stability are determined for an [unk] = 2 ultimate torsatron with large [unk] = 1 and [unk] = 3 sidebands. PMID:16592941

  12. Beta cell adaptation in pregnancy

    DEFF Research Database (Denmark)

    Nielsen, Jens Høiriis

    2016-01-01

    Pregnancy is associated with a compensatory increase in beta cell mass. It is well established that somatolactogenic hormones contribute to the expansion both indirectly by their insulin antagonistic effects and directly by their mitogenic effects on the beta cells via receptors for prolactin...... and growth hormone expressed in rodent beta cells. However, the beta cell expansion in human pregnancy seems to occur by neogenesis of beta cells from putative progenitor cells rather than by proliferation of existing beta cells. Claes Hellerström has pioneered the research on beta cell growth for decades...... in the expansion of the beta cell mass in human pregnancy, and the relative roles of endocrine factors and nutrients....

  13. Beta emitters and radiation protection

    DEFF Research Database (Denmark)

    Jødal, Lars

    2009-01-01

    BACKGROUND. Beta emitters, such as 90Y, are increasingly being used for cancer treatment. However, beta emitters demand other precautions than gamma emitters during preparation and administration, especially concerning shielding. AIM. To discuss practical precautions for handling beta emitters...... on the outside of the primary shielding material. If suitable shielding is used and larger numbers of handlings are divided among several persons, then handling of beta emitters can be a safe procedure....

  14. Hourly model to estimate solar global radiation for all months of the year for Botucatu, Sao Paulo State; Modelos horarios para estimativa da radiacao solar global para todos os meses do ano para Botucatu-SP

    Energy Technology Data Exchange (ETDEWEB)

    Laperuta Filho, Jayme; Lunardi, Dalva M. Cury [UNESP, Botucatu, SP (Brazil). Faculdade de Ciencias Agronomicas

    1997-12-31

    The objective of this work was establish and daily models for estimate of solar global radiation for the months of the year, in Botucatu-SP 22 deg C 52`S,48 deg C 26`W Grw). The obtention of these models showed be viable high degree of reliability considering that they are specific for hours and months that originated them. The coefficients a and b presented monthly and hourly variations, taking into account that b showed higher relative variability than a. In all months studied, the linear adjustment was not appropriate before 7 a.m and after 5 p.m. (author) 7 refs., 5 tabs.

  15. Beta-thalassemia

    Directory of Open Access Journals (Sweden)

    Origa Raffaella

    2010-05-01

    Full Text Available Abstract Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The total annual incidence of symptomatic individuals is estimated at 1 in 100,000 throughout the world and 1 in 10,000 people in the European Union. Three main forms have been described: thalassemia major, thalassemia intermedia and thalassemia minor. Individuals with thalassemia major usually present within the first two years of life with severe anemia, requiring regular red blood cell (RBC transfusions. Findings in untreated or poorly transfused individuals with thalassemia major, as seen in some developing countries, are growth retardation, pallor, jaundice, poor musculature, hepatosplenomegaly, leg ulcers, development of masses from extramedullary hematopoiesis, and skeletal changes that result from expansion of the bone marrow. Regular transfusion therapy leads to iron overload-related complications including endocrine complication (growth retardation, failure of sexual maturation, diabetes mellitus, and insufficiency of the parathyroid, thyroid, pituitary, and less commonly, adrenal glands, dilated myocardiopathy, liver fibrosis and cirrhosis. Patients with thalassemia intermedia present later in life with moderate anemia and do not require regular transfusions. Main clinical features in these patients are hypertrophy of erythroid marrow with medullary and extramedullary hematopoiesis and its complications (osteoporosis, masses of erythropoietic tissue that primarily affect the spleen, liver, lymph nodes, chest and spine, and bone deformities and typical facial changes, gallstones, painful leg ulcers and increased predisposition to thrombosis. Thalassemia minor is clinically asymptomatic but some subjects may have moderate anemia. Beta-thalassemias are caused by point mutations or, more rarely

  16. The beta Gumbel distribution

    Directory of Open Access Journals (Sweden)

    Saralees Nadarajah

    2004-01-01

    Full Text Available The Gumbel distribution is perhaps the most widely applied statistical distribution for problems in engineering. In this paper, we introduce a generalization—referred to as the beta Gumbel distribution—generated from the logit of a beta random variable. We provide a comprehensive treatment of the mathematical properties of this new distribution. We derive the analytical shapes of the corresponding probability density function and the hazard rate function and provide graphical illustrations. We calculate expressions for the nth moment and the asymptotic distribution of the extreme order statistics. We investigate the variation of the skewness and kurtosis measures. We also discuss estimation by the method of maximum likelihood. We hope that this generalization will attract wider applicability in engineering.

  17. Beta-thalassemia.

    Science.gov (United States)

    Galanello, Renzo; Origa, Raffaella

    2010-05-21

    Beta-thalassemias are a group of hereditary blood disorders characterized by anomalies in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The total annual incidence of symptomatic individuals is estimated at 1 in 100,000 throughout the world and 1 in 10,000 people in the European Union. Three main forms have been described: thalassemia major, thalassemia intermedia and thalassemia minor. Individuals with thalassemia major usually present within the first two years of life with severe anemia, requiring regular red blood cell (RBC) transfusions. Findings in untreated or poorly transfused individuals with thalassemia major, as seen in some developing countries, are growth retardation, pallor, jaundice, poor musculature, hepatosplenomegaly, leg ulcers, development of masses from extramedullary hematopoiesis, and skeletal changes that result from expansion of the bone marrow. Regular transfusion therapy leads to iron overload-related complications including endocrine complication (growth retardation, failure of sexual maturation, diabetes mellitus, and insufficiency of the parathyroid, thyroid, pituitary, and less commonly, adrenal glands), dilated myocardiopathy, liver fibrosis and cirrhosis). Patients with thalassemia intermedia present later in life with moderate anemia and do not require regular transfusions. Main clinical features in these patients are hypertrophy of erythroid marrow with medullary and extramedullary hematopoiesis and its complications (osteoporosis, masses of erythropoietic tissue that primarily affect the spleen, liver, lymph nodes, chest and spine, and bone deformities and typical facial changes), gallstones, painful leg ulcers and increased predisposition to thrombosis. Thalassemia minor is clinically asymptomatic but some subjects may have moderate anemia. Beta-thalassemias are caused by point mutations or, more rarely, deletions in the beta

  18. Beta and muon decays

    Energy Technology Data Exchange (ETDEWEB)

    Galindo, A.; Pascual, P.

    1967-07-01

    These notes represent a series of lectures delivered by the authors in the Junta de Energia Nuclear, during the Spring term of 1965. They were devoted to graduate students interested in the Theory of Elementary Particles. Special emphasis was focussed into the computational problems. Chapter I is a review of basic principles (Dirac equation, transition probabilities, final state interactions.) which will be needed later. In Chapter II the four-fermion punctual Interaction is discussed, Chapter III is devoted to the study of beta-decay; the main emphasis is given to the deduction of the formulae corresponding to electron-antineutrino correlation, electron energy spectrum, lifetimes, asymmetry of electrons emitted from polarized nuclei, electron and neutrino polarization and time reversal invariance in beta decay. In Chapter IV we deal with the decay of polarized muons with radiative corrections. Chapter V is devoted to an introduction to C.V.C. theory. (Author)

  19. COM Support in BETA

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann

    1999-01-01

    Component technologies based on binary units of independent production are some of the most important contributions to software architecture and reuse during recent years. Especially the COM technologies and the CORBA standard from the Object Management Group have contributed new and interesting ...... principles for software architecture, and proven to be useful in parctice. In this paper ongoing work with component support in the BETA language is described....

  20. Coroutine Sequencing in BETA

    DEFF Research Database (Denmark)

    Kristensen, Bent Bruun; Madsen, Ole Lehrmann; Møller-Pedersen, Birger

    In object-oriented programming, a program execution is viewed as a physical model of some real or imaginary part of the world. A language supporting object-oriented programming must therefore contain comprehensive facilities for modeling phenomena and concepts form the application domain. Many ap...... applications in the real world consist of objects carrying out sequential processes. Coroutines may be used for modeling objects that alternate between a number of sequential processes. The authors describe coroutines in BETA...

  1. Integration of BETA with Eclipse

    DEFF Research Database (Denmark)

    Andersen, Peter; Madsen, Ole Lehrmann; Enevoldsen, Mads Brøgger

    2004-01-01

    of language interoperability between Java and BETA is required. The first approach is to use the Java Native Interface and use C to bridge between Java and BETA. This results in a workable, but complicated solution. The second approach is to let the BETA compiler generate Java class files. With this approach......This paper presents language interoperability issues appearing in order to implement support for the BETA language in the Java-based Eclipse integrated development environment. One of the challenges is to implement plug-ins in BETA and be able to load them in Eclipse. In order to do this, some form...... it is possible to implement plug-ins in BETA and even inherit from Java classes. In the paper the two approaches are described together with part of the mapping from BETA to Java class files. http://www.sciencedirect.com/science/journal/15710661...

  2. Regulation of beta cell replication

    DEFF Research Database (Denmark)

    Lee, Ying C; Nielsen, Jens Høiriis

    2008-01-01

    Beta cell mass, at any given time, is governed by cell differentiation, neogenesis, increased or decreased cell size (cell hypertrophy or atrophy), cell death (apoptosis), and beta cell proliferation. Nutrients, hormones and growth factors coupled with their signalling intermediates have been...... suggested to play a role in beta cell mass regulation. In addition, genetic mouse model studies have indicated that cyclins and cyclin-dependent kinases that determine cell cycle progression are involved in beta cell replication, and more recently, menin in association with cyclin-dependent kinase...... inhibitors has been demonstrated to be important in beta cell growth. In this review, we consider and highlight some aspects of cell cycle regulation in relation to beta cell replication. The role of cell cycle regulation in beta cell replication is mostly from studies in rodent models, but whether...

  3. LHCb: $2\\beta_s$ measurement at LHCb

    CERN Multimedia

    Conti, G

    2009-01-01

    A measurement of $2\\beta_s$, the phase of the $B_s-\\bar{B_s}$ oscillation amplitude with respect to that of the ${\\rm b} \\rightarrow {\\rm c^{+}}{\\rm W^{-}}$ tree decay amplitude, is one of the key goals of the LHCb experiment with first data. In the Standard Model (SM), $2\\beta_s$ is predicted to be $0.0360^{+0.0020}_{-0.0016} \\rm rad$. The current constraints from the Tevatron are: $2\\beta_{s}\\in[0.32 ; 2.82]$ at 68$\\%$CL from the CDF experiment and $2\\beta_{s}=0.57^{+0.24}_{-0.30}$ from the D$\\oslash$ experiment. Although the statistical uncertainties are large, these results hint at the possible contribution of New Physics in the $B_s-\\bar{B_s}$ box diagram. After one year of data taking at LHCb at an average luminosity of $\\mathcal{L}\\sim2\\cdot10^{32}\\rm cm^{-2} \\rm s^{-1}$ (integrated luminosity $\\mathcal{L}_{\\rm int}\\sim 2 \\rm fb^{-1}$), the expected statistical uncertainty on the measurement is $\\sigma(2\\beta_s)\\simeq 0.03$. This uncertainty is similar to the $2\\beta_s$ value predicted by the SM.

  4. Pharmacologic differences between beta blockers.

    Science.gov (United States)

    Wood, A J

    1984-10-01

    All of the beta blockers act by antagonizing the actions of the endogenous adrenergic agonists epinephrine and norepinephrine at the beta-adrenergic receptors. However, a number of pharmacologic differences exist between the various agents. Some drugs, such as atenolol and metoprolol, are relatively selective for the beta-1-adrenergic receptors, requiring higher concentrations to block beta-2-adrenergic receptors than are required to block beta-1 receptors. It should be noted, however, that these selective beta blockers all block beta-2 receptors when their concentrations are high enough. When patients with asthma must receive a beta blocker, low doses of a selective drug should be used. Recent studies, however, have suggested that the use of a nonselective beta blocker may be desirable to antagonize some beta-2-mediated metabolic effects, such as hypokalemia, induced by epinephrine. Pindolol is the only beta-receptor antagonist available in the United States with intrinsic sympathomimetic, or partial agonist, activity. Such drugs, because of their partial agonist activity, cause some sympathetic stimulation under conditions of low endogenous sympathetic tone, such as while subjects are at rest in the supine position. Under conditions of higher sympathetic tone, pindolol blocks the effects of the endogenous agonists, producing the characteristic effects of a beta blocker. Membrane-stabilizing activity was first recognized with propranolol, and the value of this property has been a source of controversy ever since, but recent studies suggest that propranolol may induce electrophysiologic effects by mechanisms other than beta blockade. Pharmacokinetic differences between the drugs are also of importance.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. Application of low doses of ionizing radiation in the Brazilian fruit tucuma (Astrocaryum vulgare Mart.); Aplicacao de baixas doses de radiacao ionizante no fruto brasileiro tucuma (Astrocaryum vulgare Mart.)

    Energy Technology Data Exchange (ETDEWEB)

    Lima, Antonio Luis dos Santos; Lima, Keila dos Santos Cople; Araujo, Leandro Moreira, E-mail: santoslima@ime.eb.b, E-mail: keila@ime.eb.b [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil); Gody, Ronoel Luiz de Oliveira; Pacheco, Sidney, E-mail: ronoel@ctaa.embrapa.b, E-mail: sidney@ctaa.embrapa.b [EMBRAPA Agroindustria de Alimentos (CTAA), Rio de Janeiro, RJ (Brazil)

    2011-07-01

    The tucuma (Astrocaryum vulgare Mart.) is a native fruit of Amazonia, occurring mainly in the state of Para, but also found in the Brazilian northeast states and in the Brazilian central-western states. The tucuma is considered an excellent source of carotenoids with a very high concentration of {beta}-carotene, which is a precursor of vitamin A. In addition to carotenoids it is an important source of vitamin B2 (riboflavin) in fruits. This study aimed to analyze the effects of gamma radiation on the nutritional value of tucuma. The fruits were irradiated at doses of 0.5, 1.0 and 2.0 kGy irradiator with a source of cesium 137. The carotenoids were determined by spectrophotometry. The analysis of {alpha} and {beta}-carotene, thiamine, riboflavin were carried out by high performance liquid chromatography (HPLC). The {beta}-carotene accounts for 80% of total carotenoids in tucuma, and with a dose of 2 kGy, it showed the highest reduction of {beta}-carotene, about 7.5% in relation to the control. The tucuma fruit showed high levels of riboflavin from 0.183 to 0.222 {mu}g 100 g{sup -1}, and maintained stability after the gamma radiation process. However, it had low levels of thiamine from 0.050 to 0.033 {mu}g 100 g{sup -1}, and irradiated at a dose of 2 kGy showed significant reductions of thiamine, about 34% in relation to the control. (author)

  6. [Beta-blocker intoxication].

    Science.gov (United States)

    Joye, F

    2000-05-20

    Beta-blocker intoxication is not frequent but can produce particularly severe or fatal conditions which must not be underestimated. Severity of beta-blocker intoxication varies from one compound to another. The more toxic drugs are propranolol, sotalol, oxprenolol, metoprolol, atenolol, acebutolol, labetalol, and carvedilol. Besides the drug type, history taking can provide a precise assessment of risk, particularly important in when elderly patients with a cardiovascular history have taken more than 20 tablets, when emergency care is provided late, and when other cardiotoxic or psychotoxic drugs have been coingested. The diagnosis of beta-blocker intoxication must be suspected in any case associating hypotension and bradycardia. The main cardiovascular complications are cardiogenic shock, atrio-ventricular conduction disorders, and obviously life-threatening ventricular arrhythmia with cardiac arrest. Centrally induced respiratory arrest is a rare but dreadful consequence which can occur suddenly even without hemodynamic failure. Neurologic toxicity is mainly expressed by consciousness disorders and more sporadically by seizures. Laboratory tests show variable serum potassium, lactic acidosis, hypoxia-hypercapnia resulting from hypoventilation, and rarely hypoglycemia. The ECG should be recorded early because electrocardiographic signs usually appear before clinical signs and QRS enlargement is a factor predictive of severe ventricular arrhythmia. The patient must be placed in an intensive care unit for continuous multiparametric monitoring. Besides gastric evacuation and symptomatic measures, treatment essentially requires glucagon for its positive inotropic effect after high intravenous doses. If glucagon infusion is ineffective or unavailable, an alternative would be to use high doses of vasoactive agents, choosing isoproterenol or epinephrine as the first intention drugs.

  7. Conditional Betas and Investor Uncertainty

    OpenAIRE

    Fernando D. Chague

    2013-01-01

    We derive theoretical expressions for market betas from a rational expectation equilibrium model where the representative investor does not observe if the economy is in a recession or an expansion. Market betas in this economy are time-varying and related to investor uncertainty about the state of the economy. The dynamics of betas will also vary across assets according to the assets' cash-flow structure. In a calibration exercise, we show that value and growth firms have cash-flow structures...

  8. ACCOUNTING INFORMATION AND MARKET BETA

    OpenAIRE

    Amorim, Ana Luísa Gambi Cavallari; Lima, Iran Siqueira; Pimenta Junior,Tabajara

    2014-01-01

    The efficient market hypothesis and various models of asset pricing brought the concept of the new relevant information has an immediate effect on the price of a security by changing expectations about their risk: market beta. The accounting numbers seem to exhibit a relationship with the market risk of firms and thus can provide a supplementary estimate to help reduce the error of estimation of market betas. This work was to investigate whether the accounting betas have a business relationsh...

  9. Supersymmetry Inspired QCD Beta Function

    CERN Document Server

    Ryttov, Thomas A

    2008-01-01

    We propose an all orders beta function for ordinary Yang-Mills theories with or without fermions inspired by the Novikov-Shifman-Vainshtein-Zakharov beta function of N=1 supersymmetric gauge theories. The beta function allows us to bound the conformal window. When restricting to one adjoint Weyl fermion we show how the proposed beta function matches the one of supersymmetric Yang-Mills theory. The running of the pure Yang-Mills coupling is computed and the deviation from the two loop result is presented. We then compare the deviation with the one obtained from lattice data also with respect to the two loop running.

  10. Supersymmetry Inspired QCD Beta Function

    DEFF Research Database (Denmark)

    Ryttov, Thomas; Sannino, Francesco

    2008-01-01

    We propose an all orders beta function for ordinary Yang-Mills theories with or without fermions inspired by the Novikov-Shifman-Vainshtein-Zakharov beta function of N=1 supersymmetric gauge theories. The beta function allows us to bound the conformal window. When restricting to one adjoint Weyl...... fermion we show how the proposed beta function matches the one of supersymmetric Yang-Mills theory. The running of the pure Yang-Mills coupling is computed and the deviation from the two loop result is presented. We then compare the deviation with the one obtained from lattice data also with respect...

  11. Identification of active anti-inflammatory principles of beta- beta ...

    African Journals Online (AJOL)

    Purpose: To identify the anti-inflammatory components of beta-beta (Lunasia amara Blanco.) wood. Methods: The wood material was extracted with 96 % ethanol and fractionated with dichloromethane using a liquid-liquid continuous extraction (LLCE). The fractions were subjected to silica gel column chromatography.

  12. Beta section beta : biogeographical patterns of variation, and taxonomy

    NARCIS (Netherlands)

    Letschert, J.P.W.

    1993-01-01

    In Chapter 1 an account is given of the historical subdivision of the genus Beta and its sections, and the relations of the sections are discussed. Emphasis is given to the taxonomic treatment of wild section Beta by various authors. The Linnaean

  13. Conversion of beta-methylbutyric acid to beta-hydroxy-beta-methylbutyric acid by Galactomyces reessii.

    OpenAIRE

    Lee, I. Y.; Nissen, S L; Rosazza, J P

    1997-01-01

    beta-Hydroxy-beta-methylbutyric acid (HMB) has been shown to increase strength and lean mass gains in humans undergoing resistance-exercise training. HMB is currently marketed as a calcium salt of HMB, and thus, environmentally sound and inexpensive methods of manufacture are being sought. This study investigates the microbial conversion of beta-methylbutyric acid (MBA) to HMB by cultures of Galactomyces reessii. Optimal concentrations of MBA were in the range of 5 to 20 g/liter for HMB produ...

  14. Beta Function and Anomalous Dimensions

    DEFF Research Database (Denmark)

    Pica, Claudio; Sannino, Francesco

    2011-01-01

    We demonstrate that it is possible to determine the coefficients of an all-order beta function linear in the anomalous dimensions using as data the two-loop coefficients together with the first one of the anomalous dimensions which are universal. The beta function allows to determine the anomalous...

  15. RAVEN Beta Release

    Energy Technology Data Exchange (ETDEWEB)

    Rabiti, Cristian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Alfonsi, Andrea [Idaho National Lab. (INL), Idaho Falls, ID (United States); Cogliati, Joshua Joseph [Idaho National Lab. (INL), Idaho Falls, ID (United States); Mandelli, Diego [Idaho National Lab. (INL), Idaho Falls, ID (United States); Kinoshita, Robert Arthur [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wang, Congjian [Idaho National Lab. (INL), Idaho Falls, ID (United States); Maljovec, Daniel Patrick [Idaho National Lab. (INL), Idaho Falls, ID (United States); Talbot, Paul William [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-02-01

    This documents the release of the Risk Analysis Virtual Environment (RAVEN) code. A description of the RAVEN code is provided, and discussion of the release process for the M2LW-16IN0704045 milestone. The RAVEN code is a generic software framework to perform parametric and probabilistic analysis based on the response of complex system codes. RAVEN is capable of investigating the system response as well as the input space using Monte Carlo, Grid, or Latin Hyper Cube sampling schemes, but its strength is focused toward system feature discovery, such as limit surfaces, separating regions of the input space leading to system failure, using dynamic supervised learning techniques. RAVEN has now increased in maturity enough for the Beta 1.0 release.

  16. Beta Beams Implementation at CERN

    CERN Document Server

    Hansen, Christian

    2011-01-01

    Beta Beam,the concept of generating a pure and intense (anti) neutrino beam by letting accelerated radioactive ions beta decay in a storage ring, called Decay Ring (DR), is the base of one of the proposed next generation neutrino oscillation facilities, necessary for a complete study of the neutrino oscillation parameter space. Sensitivities of the unknown neutrino oscillation parameters depend on the Decay Ring's ion intensity and of it's duty factor (the filled ratio of the ring). Therefore efficient ion production, stripping, bunching, acceleration and storing are crucial sub-projects under study and development within the Beta Beam collaboration. Specifically the feasibility of these tasks as parts of a Beta Beam implementation at CERN will be discussed in this report. The positive impact of the large {\\theta}13 indications from T2K on the Beta Beam performance will also be discussed.

  17. Can Beta Blockers Cause Weight Gain?

    Science.gov (United States)

    Beta blockers: Do they cause weight gain? Can beta blockers cause weight gain? Answers from Sheldon G. Sheps, ... can occur as a side effect of some beta blockers, especially the older ones, such as atenolol (Tenormin) ...

  18. Avaliação da acurácia de testes laboratoriais para detecção de amostras de Klebsiella pneumoniae produtora de betalactamase de espectro estendido Comparison of different methods for detection of Klebsiella pneumoniae isolates producers of extended spectrum beta-lactamase

    Directory of Open Access Journals (Sweden)

    Andrea dos Santos Pereira

    2003-01-01

    Full Text Available Bactérias produtoras de betalactamase de espectro estendido (ESBL representam um dos mais importantes problemas de resistência bacteriana nos hospitais brasileiros. A necessidade da implementação de testes que apresentem alta acurácia e baixo custo é de suma importância devido à dificuldade na detecção de ESBL. O objetivo do presente estudo foi avaliar a acurácia dos testes de adição de ácido clavulânico comercializados pela Oxoid® (Basingstoke, Inglaterra e do Etest ESBL Screen® (AB Biodisk, Solna, Suécia para detecção de K. pneumoniae produtoras de ESBL. Objetivamos também avaliar comparativamente a sensibilidade e a especificidade dos substratos betalactâmicos utilizados nestas metodologias. Foram avaliadas 134 amostras de K. pneumoniae isoladas em hemocultura de pacientes internados no Hospital São Paulo no período de julho de 1996 a julho de 2001. As amostras foram avaliadas quanto à produção de ESBL pelo teste de triagem preconizado pelo National Committee for Clinical Laboratory Standards (NCCLS, adição de ácido clavulânico (Oxoid® e Etest ESBL Screen®. Foram consideradas produtoras de ESBL (padrão-ouro amostras que apresentaram teste de triagem positivo e pelo menos um dos dois testes avaliados também positivo. O teste de adição de ácido clavulânico (Oxoid® apresentou 100% de sensibilidade e 100% de especificidade, e os substratos que apresentaram melhor desempenho neste teste foram cefotaxima e cefpodoxima, ambos com 100% de sensibilidade e especificidade. O Etest ESBL Screen® apresentou 96% de sensibilidade e 100% de especificidade, sendo que a cefotaxima mostrou novamente melhor desempenho, com 92,5% de sensibilidade e 100% de especificidade. O teste de adição de ácido clavulânico (Oxoid® apresentou excelente desempenho e pode ser facilmente implementado na rotina laboratorial por ser de alta acurácia e de fáceis realização e interpretação.Bacterial strains producing extended

  19. Experiments on double beta decay

    Energy Technology Data Exchange (ETDEWEB)

    Busto, J. [Neuchatel Univ. (Switzerland). Inst. de Physique

    1996-11-01

    The Double Beta Decay, and especially ({beta}{beta}){sub 0{nu}} mode, is an excellent test of Standard Model as well as of neutrino physics. From experimental point of view, a very large number of different techniques are or have been used increasing the sensitivity of this experiments quite a lot (the factor of 10{sup 4} in the last 20 years). In future, in spite of several difficulties, the sensitivity would be increased further, keeping the interest of this very important process. (author) 4 figs., 5 tabs., 21 refs.

  20. Variants of beta-glucosidase

    Energy Technology Data Exchange (ETDEWEB)

    Fidantsef, Ana; Lamsa, Michael; Gorre-Clancy, Brian

    2015-07-14

    The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

  1. Variants of beta-glucosidases

    Energy Technology Data Exchange (ETDEWEB)

    Fidantsef, Ana; Lamsa, Michael; Gorre-Clancy, Brian

    2014-10-07

    The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

  2. Variants of beta-glucosidase

    Science.gov (United States)

    Fidantsef, Ana [Davis, CA; Lamsa, Michael [Davis, CA; Gorre-Clancy, Brian [Elk Grove, CA

    2009-12-29

    The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

  3. Dosimetry of {beta} extensive sources; Dosimetria de fuentes {beta} extensas

    Energy Technology Data Exchange (ETDEWEB)

    Rojas C, E.L.; Lallena R, A.M. [Departamento de Fisica Moderna, Universidad de Granada, E-18071 Granada (Spain)

    2002-07-01

    In this work, we have been studied, making use of the Penelope Monte Carlo simulation code, the dosimetry of {beta} extensive sources in situations of spherical geometry including interfaces. These configurations are of interest in the treatment of the called cranealfaringyomes of some synovia leisure of knee and other problems of interest in medical physics. Therefore, its application can be extended toward problems of another areas with similar geometric situation and beta sources. (Author)

  4. Mensuration of equivalent dose with personal dosemeters and instruments of radiological protection in the new operative quantities ICRU, for external fields of beta radiation. Part II. I study of the angular response of personal dosemeters TLD-100 in secondary patron fields of beta radiation ({sup 90}Sr / {sup 90}Y); Medicion de dosis equivalente con dosimetros personales e instrumentos de proteccion radiologica en las nuevas magnitudes operativas ICRU, para campos de radiacion beta externos. Parte II. Estudio de la respuesta angular de dosimetros personales TLD-100 en campos patrones secundarios de radiacion beta ({sup 90}Sr/{sup 90}Y)

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, J.T. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1994-01-15

    The objective of this work is to carry out one of the possible ones test type for personal dosemeters TLD, under the recomendations of the ICRU 39, ICRU 43 and the draft of the norm ISO 6980,(1992), with the purpose of verifying the capacity of these detectors to carry out the operative unit: H' (0.07;{alpha}). Since H' (O. 07;{alpha}) this defined one in an expanded field, one of these tests type consist on determining the angular response of these detectors. 20 personal dosemeters TLD-100 was used, (card marks: Harshaw, Model: G-1, with two glasses of TLD-100 absorbed in teflon; the portadosemeters has two windows, a free one and another with a filter of Pb of 171.0 mg cm{sup -2}); these dosemeters they were previously selected, [to see, {sup S}tudy of the Homogeneity of the response of Personal Dosemeters (Cards G-l, TLD-100) in Radiation of Countrysides of {sup 60}Co{sup ,} J.T. Alvarez R. Technician Report GSR/IT/0001/94].The irradiations to effectued in secondary countryside of radiation beta of {sup 90}Sr/{sup 90}Y. The study was undertaken by means of an experimental design of blocks random that contemplate the following variables: intensity of the radiation source, (1850 MBq and 74 MBq); position of irradiation, (four positions); incidence of angle of the radiation (0, 15, 30, 45, 60 and 75 grades) and the absorbed dose in air, (0.005, 0.010, 0.020, 0.050 and 0.100 Gy). Then null hypothesis it was to suppose that there was not difference among the stockings of each treatment, to used the statistical of Duncan to carry out tests of stockings at a level of significance of 5%.These tests of stockings throw the following results in those variables of the experimental design: The irradiations carried out so much with the source pattern secondary of {sup 90}Sr/{sup 90}Y of 1850 MBq and of 74 MBq, they are equivalent reason why they can be used indistinctly. The responses of each one of the glasses of the card are strongly anisotropic for each glass

  5. Angular and energy dependence of radiation protection monitors to the quantity ambient dose equivalent for gamma radiation;Dependencia angular e energetica de monitores de radioprotecao para medidas de equivalente de dose ambiental para radiacao gama

    Energy Technology Data Exchange (ETDEWEB)

    Nonato, Fernanda B.C.; Carvalho, Valdir S.; Diniz, Raphael E.; Caldas, Linda V.E. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2009-07-01

    In Brazil, most of the equipment used for monitoring area is just used in the quantities exposure and absorbed dose, with the need of adjustment to the ambient dose equivalent, H{sup *}(10). In this work, 19 Geiger-Mueller detectors and 7 ionization chambers were calibrated in the Calibration Laboratory of the Instituto de Pesquisas Energeticas Nucleares, IPEN. The energy dependence of these radiation detectors was studied for gamma radiation ({sup 137}Cs e {sup 60}Co) and the angular dependence, for {sup 137}Cs radiation. (author)

  6. Subtype-selective modulation of human beta 1- and beta 2-adrenoceptor function by beta-adrenoceptor agonists and antagonists

    NARCIS (Netherlands)

    Brodde, O. E.; Daul, A.; Michel, M. C.

    1990-01-01

    In healthy volunteers a 14-day treatment with the selective beta 1-adrenoceptor agonist xamoterol (2 x 200 mg/day) desensitized beta 1-adrenoceptor-mediated physiological effects, but did not affect beta 2-adrenoceptor-mediated effects; in contrast, a 9-day treatment with the selective beta

  7. Selective regulation of beta 1- and beta 2-adrenoceptors in the human heart by chronic beta-adrenoceptor antagonist treatment

    NARCIS (Netherlands)

    Michel, M. C.; Pingsmann, A.; Beckeringh, J. J.; Zerkowski, H. R.; Doetsch, N.; Brodde, O. E.

    1988-01-01

    1. In 44 patients undergoing coronary artery bypass grafting, the effect of chronic administration of the beta-adrenoceptor antagonists sotalol, propranolol, pindolol, metoprolol and atenolol on beta-adrenoceptor density in right atria (containing 70% beta 1- and 30% beta 2-adrenoceptors) and in

  8. El factor de crecimiento transformante beta como blanco terapéutico Transforming growth factor-beta as a therapeutic target

    Directory of Open Access Journals (Sweden)

    Francisco Javier Gálvez-Gastélum

    2004-08-01

    Full Text Available El factor de crecimiento transformante beta (TGF-beta es una familia de proteínas que incluye al TGF-beta, activinas y a la proteína morfogénica de hueso (BMP, por sus siglas en inglés, citocinas que son secretadas y se relacionan estructuralmente en diferentes especies de metazoarios. Los miembros de la familia del TGF-beta regulan diferentes funciones celulares como proliferación, apoptosis, diferenciación, migración, y tienen un papel clave en el desarrollo del organismo. El TGF-beta está implicado en varias patologías humanas, incluyendo desórdenes autoinmunes y vasculares, así como enfermedades fibróticas y cáncer. La activación del receptor del TGF-beta propicia su fosforilación en residuos de serina/treonina y dispara la fosforilación de proteínas efectoras intracelulares (smad, que una vez activas se translocan al núcleo para inducir la transcripción de genes blanco, y así regular procesos y funciones celulares. Se están desarrollando novedosas estrategias terapéuticas encaminadas a corregir las alteraciones presentes en patologías que involucran al TGF-beta como actor principal.Transforming growth factor-beta (TGF-beta family members include TGF-beta, activins, and bone morphogenetic proteins (BMP. These proteins are structurally related cytokines secreted in diverse Metazoans. TGF-beta family members regulate cellular functions such as proliferation, apoptosis, differentiation, and migration, and play an important role in organism development. Deregulated TGF-beta family signaling participates in various human pathologies including auto-immune diseases, vascular disorders, fibrotic disease, and cancer. Ligand-induced activation of TGF-beta family receptors with intrinsic serine/threonine kinase activity, triggers phosphorylation of the intracellular effectors of TGF-beta signaling, the Smads proteins. Once these proteins are activated they translocate into the nucleus, where they induce transcription of target

  9. Beta-Testing Agreement | FNLCR

    Science.gov (United States)

    Beta-Testing Agreements are appropriate forlimited term evaluation and applications development of new software, technology, or equipment platforms by the Frederick National Labin collaboration with an external commercial partner. It may

  10. Beta-carotene blood test

    Science.gov (United States)

    ... medlineplus.gov/ency/article/003571.htm Beta-carotene blood test To use the sharing features on this page, ... skin is broken) Alternative Names Carotene test Images Blood test References Chernecky CC, Berger BJ. Carotene - serum. In: ...

  11. Polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same

    Science.gov (United States)

    Morant, Marc

    2017-02-07

    The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  12. Neutrophil beta-2 microglobulin: an inflammatory mediator

    DEFF Research Database (Denmark)

    Bjerrum, O W; Nissen, Mogens Holst; Borregaard, N

    1990-01-01

    vesicles, and plasma membrane. Beta 2m was released in the native form from neutrophils in response to stimulation with chemotactic stimuli and phorbol ester. The results of experiments designed to study the modification of native beta 2m by neutrophils indicated that neutrophils do not participate...... in the proteolysis of beta 2m. However, we demonstrated that native beta 2m following degranulation may be transformed to Des-Lys58-beta 2m by lymphocytes. We suggest that neutrophil beta 2m following exocytosis may be transformed to Des-Lys58-beta 2m, acting as an extracellular messenger between granulocytes...

  13. Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow

    DEFF Research Database (Denmark)

    Potocnik, A J; Brakebusch, C; Fässler, R

    2000-01-01

    Homing of hematopoietic stem cells (HSCs) into hematopoietic organs is a prerequisite for the establishment of hematopoiesis during embryogenesis and after bone marrow transplantation. We show that beta1 integrin-deficient HSCs from the para-aortic splanchnopleura and the fetal blood had...... hematolymphoid differentiation potential in vitro and in fetal organ cultures but were unable to seed fetal and adult hematopoietic tissues. Adult beta1 integrin null HSCs isolated from mice carrying loxP-tagged beta1 integrin alleles and ablated for beta1 integrin expression by retroviral cre transduction...... failed to engraft irradiated recipient mice. Moreover, absence of beta1 integrin resulted in sequestration of HSCs in the circulation and their reduced adhesion to endothelioma cells. These findings define beta1 integrin as an essential adhesion receptor for the homing of HSCs....

  14. Tables of double beta decay data

    Energy Technology Data Exchange (ETDEWEB)

    Tretyak, V.I. [AN Ukrainskoj SSR, Kiev (Ukraine)]|[Strasbourg-1 Univ., 67 (France). Centre de Recherches Nucleaires; Zdesenko, Y.G. [AN Ukrainskoj SSR, Kiev (Ukraine)

    1995-12-31

    A compilation of experimental data on double beta decay is presented. The tables contain the most stringent known experimental limits or positive results of 2{beta} transitions of 69 natural nuclides to ground and excited states of daughter nuclei for different channels (2{beta}{sup -}; 2{beta}{sup +}; {epsilon}{beta}{sup +}; 2{epsilon}) and modes (0{nu}; 2{nu}; 0{nu}M) of decay. (authors). 189 refs., 9 figs., 3 tabs.

  15. TGF-beta1, -beta2 and -beta3 cooperate to facilitate tubulogenesis in the explanted quail heart.

    Science.gov (United States)

    Holifield, Jennifer S; Arlen, Angela M; Runyan, Raymond B; Tomanek, Robert J

    2004-01-01

    Transforming growth factor-beta (TGF-beta) isoforms have been implicated as both pro- and anti-angiogenic modulators. In this study we addressed the roles of TGF-beta isoforms on coronary tubulogenesis. Embryonic (E6) quail ventricular specimens were explanted onto collagen gels allowing endothelial cells to migrate and form vascular tubes. Growth factors and/or neutralizing growth factor antibodies were added to the cultures. Endothelial cells were identified using a quail endothelial cell marker, QH1. Image analysis was used to quantify aggregate tube length. Addition of any isoform (TGF-beta(1), TGF-beta(2) or TGF-beta(3)) virtually prevented tubulogenesis (>95% inhibition), while stimulation of tubulogenesis occurred by adding neutralizing antibodies to TGF-beta(3), but not to TGF-beta(1) or -beta(2). When all three isoforms were added, tubulogenesis was enhanced, indicating the key role of TGF-beta(3). Documentation of the inhibitory effect of TGF-beta isoforms on tubulogenesis is further supported by our experiments in which the marked enhancement of tube formation by bFGF and VEGF was negated when exogenous TGF-beta(1), -beta(2), or -beta(3) were added to the cultures. (1) TGF-beta(1), -beta(2) and -beta(3) each inhibits angiogenesis; (2) cooperation between the three TGF-beta isoforms and other angiogenic factors is essential for the regulation of normal tubulogenesis and (3) the stimulatory effect of VEGF or bFGF on tubulogenesis is negated by exogenous TGB-betas. Copyright 2004 S. Karger AG, Basel.

  16. In-trap decay spectroscopy for {beta}{beta} decays

    Energy Technology Data Exchange (ETDEWEB)

    Brunner, Thomas

    2011-01-18

    The presented work describes the implementation of a new technique to measure electron-capture (EC) branching ratios (BRs) of intermediate nuclei in {beta}{beta} decays. This technique has been developed at TRIUMF in Vancouver, Canada. It facilitates one of TRIUMF's Ion Traps for Atomic and Nuclear science (TITAN), the Electron Beam Ion Trap (EBIT) that is used as a spectroscopy Penning trap. Radioactive ions, produced at the radioactive isotope facility ISAC, are injected and stored in the spectroscopy Penning trap while their decays are observed. A key feature of this technique is the use of a strong magnetic field, required for trapping. It radially confines electrons from {beta} decays along the trap axis while X-rays, following an EC, are emitted isotropically. This provides spatial separation of X-ray and {beta} detection with almost no {beta}-induced background at the X-ray detector, allowing weak EC branches to be measured. Furthermore, the combination of several traps allows one to isobarically clean the sample prior to the in-trap decay spectroscopy measurement. This technique has been developed to measure ECBRs of transition nuclei in {beta}{beta} decays. Detailed knowledge of these electron capture branches is crucial for a better understanding of the underlying nuclear physics in {beta}{beta} decays. These branches are typically of the order of 10{sup -5} and therefore difficult to measure. Conventional measurements suffer from isobaric contamination and a dominating {beta} background at theX-ray detector. Additionally, X-rays are attenuated by the material where the radioactive sample is implanted. To overcome these limitations, the technique of in-trap decay spectroscopy has been developed. In this work, the EBIT was connected to the TITAN beam line and has been commissioned. Using the developed beam diagnostics, ions were injected into the Penning trap and systematic studies on injection and storage optimization were performed. Furthermore, Ge

  17. Beta-blockers for hypertension

    Science.gov (United States)

    Wiysonge, Charles S; Bradley, Hazel A; Volmink, Jimmy; Mayosi, Bongani M; Opie, Lionel H

    2017-01-01

    Background Beta-blockers refer to a mixed group of drugs with diverse pharmacodynamic and pharmacokinetic properties. They have shown long-term beneficial effects on mortality and cardiovascular disease (CVD) when used in people with heart failure or acute myocardial infarction. Beta-blockers were thought to have similar beneficial effects when used as first-line therapy for hypertension. However, the benefit of beta-blockers as first-line therapy for hypertension without compelling indications is controversial. This review is an update of a Cochrane Review initially published in 2007 and updated in 2012. Objectives To assess the effects of beta-blockers on morbidity and mortality endpoints in adults with hypertension. Search methods The Cochrane Hypertension Information Specialist searched the following databases for randomized controlled trials up to June 2016: the Cochrane Hypertension Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL) (2016, Issue 6), MEDLINE (from 1946), Embase (from 1974), and ClinicalTrials.gov. We checked reference lists of relevant reviews, and reference lists of studies potentially eligible for inclusion in this review, and also searched the the World Health Organization International Clinical Trials Registry Platform on 06 July 2015. Selection criteria Randomised controlled trials (RCTs) of at least one year of duration, which assessed the effects of beta-blockers compared to placebo or other drugs, as first-line therapy for hypertension, on mortality and morbidity in adults. Data collection and analysis We selected studies and extracted data in duplicate, resolving discrepancies by consensus. We expressed study results as risk ratios (RR) with 95% confidence intervals (CI) and conducted fixed-effect or random-effects meta-analyses, as appropriate. We also used GRADE to assess the certainty of the evidence. GRADE classifies the certainty of evidence as high (if we are confident that the true effect lies

  18. Evidence of inhibin/activin subunit betaC and betaE synthesis in normal human endometrial tissue

    Directory of Open Access Journals (Sweden)

    Shabani Naim

    2010-11-01

    Full Text Available Abstract Background Inhibins are important regulators of the female reproductive system. Recently, two new inhibin subunits betaC and betaE have been described, although it is unclear if they are synthesized in normal human endometrium. Methods Samples of human endometrium were obtained from 82 premenopausal, non-pregnant patients undergoing gynecological surgery for benign diseases. Endometrium samples were classified according to anamnestic and histological dating into proliferative (day 1-14, n = 46, early secretory (day 15-22, n = 18 and late secretory phase (day 23-28, n = 18. Immunohistochemical analyses were performed with specific antibodies against inhibin alpha (n = 81 as well as inhibin betaA (n = 82, betaB (n = 82, betaC (n = 74 and betaE (n = 76 subunits. RT-PCR was performed for all inhibin subunits. Correlation was assessed with the Spearman factor to assess the relationship of inhibin-subunits expression within the different endometrial samples. Results The novel inhibin betaC and betaE subunits were found in normal human endometrium by immunohistochemical and molecular techniques. Inhibin alpha, betaA, betaB and betaE subunits showed a circadian expression pattern, being more abundant during the late secretory phase than during the proliferative phase. Additionally, a significant correlation between inhibin alpha and all inhibin beta subunits was observed. Conclusions The differential expression pattern of the betaC- and betaE-subunits in normal human endometrial tissue suggests that they function in endometrial maturation and blastocyst implantation. However, the precise role of these novel inhibin/activin subunits in human endometrium is unclear and warrants further investigation.

  19. Plant and algal interference in bacterial beta-D-galactosidase and beta-D-glucuronidase assays.

    OpenAIRE

    Davies, C M; Apte, S C; Peterson, S M; Stauber, J L

    1994-01-01

    Several commonly occurring freshwater and marine plants and algae were screened for beta-D-galactosidase and beta-D-glucuronidase activities by using a 60-min enzyme assay based on the hydrolysis by these enzymes of 4-methylumbelliferyl-beta-D-galactoside and 4-methylumbelliferyl- beta-glucuronide, respectively. All freshwater plant extracts tested showed beta-D-galactosidase activity several at relatively high levels, and a number also showed beta-D-glucuronidase activity. A number of the ma...

  20. Smart Beta or Smart Alpha

    DEFF Research Database (Denmark)

    Winther, Kenneth Lillelund; Steenstrup, Søren Resen

    2016-01-01

    Smart beta has become the flavor of the decade in the investment world with its low fees, easy access to rewarded risk premiums, and appearance of providing good investment results relative to both traditional passive benchmarks and actively managed funds. Although we consider it well documented...... that smart beta investing probably will do better than passive market capitalization investing over time, we believe many are coming to a conclusion too quickly regarding active managers. Institutional investors are able to guide managers through benchmarks and risk frameworks toward the same well......-documented smart beta risk premiums and still motivate active managers to avoid value traps, too highly priced small caps, defensives, etc. By constructing the equity portfolios of active managers that resemble the most widely used risk premiums, we show that the returns and risk-adjusted returns measures...

  1. Covariances of nuclear matrix elements for O{nu}{beta}{beta} decay

    Energy Technology Data Exchange (ETDEWEB)

    Fogli, G L; Rotunno, A M [Dipartimento Interateneo di Fisica ' Michelangelo Merlin' , Via Orabona 4, 70126 Bari (Italy); Lisi, E, E-mail: annamaria.rotunno@ba.infn.i [Istituto Nazionale di Fisica Nucleare, Sezione di Bari, Via Orabona 4, 70126 Bari (Italy)

    2010-01-01

    Estimates of nuclear matrix elements (NME) for neutrinoless double beta decay (O{nu}{beta}{beta}) based on the quasiparticle random phase approximations (QRPA) are affected by theoretical uncertainties, which may play a dominant role in comparison with projected experimental errors of future O{nu}{beta}{beta} experiments. We discuss the estimated variances and covariances of NME of several candidate nuclei within the QRPA, focusing on the following aspects: 1) the comparison of O{nu}{beta}{beta} signals, or limits, in different nuclei; 2) the prospects for testing nonstandard O{nu}2{beta} mechanisms in future experiments.

  2. A {beta} - {gamma} coincidence; Metodo de coincidencias {beta} - {gamma}

    Energy Technology Data Exchange (ETDEWEB)

    Agullo, F.

    1960-07-01

    A {beta} - {gamma} coincidence method for absolute counting is given. The fundamental principles are revised and the experimental part is detailed. The results from {sup 1}98 Au irradiated in the JEN 1 Swimming pool reactor are given. The maximal accuracy is 1 per cent. (Author) 11 refs.

  3. Implante de arcabouços de poli (ácido lático-co-glicólico associados à hidroxiapatita, beta tricálcio fosfato e células - tronco mesenquimais de tecido adiposo humano em calota craniana de ratos wistar para estímulo da regeneração óssea

    Directory of Open Access Journals (Sweden)

    Felipe Caldeira Campioni

    2015-10-01

    Full Text Available A engenharia tecidual é um campo interdisciplinar que se baseia nos conhecimentos de novos materiais e técnicas para reconstrução, reparação e/ou substituição de órgãos e tecidos danificados. (CASAGRANDE et al., 2009. Neste cenário, o uso de polímeros biorreabsorvíveis, como o PLGA, vem se destacando como ferramenta de reconstrução tecidual. (SANTOS, 2007 O polímero em questão combinado com materiais cerâmicos, como hidroxiapatita e beta tricálcio fosfato (PLGA HA/βTCP possuem intensa bioatividade na indução do crescimento ósseo. As células-tronco mesenquimais humanas constituem uma promissora área na medicina regenerativa, devido a sua capacidade de diferenciação osteogênica. (PAK, 2011 O propósito do projeto foi avaliar a biocompatibilidade do PLGA com seus compostos cerâmicos e aliados a células- tronco mesenquimais de tecido adiposo humano através de implantes realizados na calota craniana de ratos. Os testes foram realizados in vivo e esperava-se que os ratos submetidos aos tratamentos citados com o arcabouço teriam uma melhor cicatrização e restauração óssea do que aqueles do grupo controle. Foram utilizados 42 ratos Wistar de ambos os sexos, com idade aproximada de dois meses, pesando entre 250 e 300g; todos os animais receberam tratamento com ração comercial e água ad libitum. Após o período de implante de 8 e 12 semanas os ratos foram sacrificados por overdose de Halotano, as amostras sofreram um processo de descalcificação e foram realizadas análises das lâminas. A histologia mostrou que no grupo de PLGA HA/βTCP puro houve neoformação óssea e remodelação em áreas contíguas às bordas, porém no grupo com células mesenquimais, apesar do tecido estar irregular e fragmentado, houve formação de osso sem continuidade com as bordas, um indicativo de indução osteogênica. A histomorfometria evidenciou grandes áreas de osso primário nos grupos tratados em relação ao controle

  4. Production of poly-(beta-hydroxybutyric-co-beta-hydroxyvaleric) acids.

    Science.gov (United States)

    Ramsay, B A; Lomaliza, K; Chavarie, C; Dubé, B; Bataille, P; Ramsay, J A

    1990-01-01

    Alcaligenes latus, Alcaligenes eutrophus, Bacillus cereus, Pseudomonas pseudoflava, Pseudomonas cepacia, and Micrococcus halodenitrificans were found to accumulate poly-(beta-hydroxybutyric-co-beta-hydroxyvaleric) acid [P(HB-co-HV)] copolymer when supplied with glucose (or sucrose in the case of A. latus) and propionic acid under nitrogen-limited conditions. A fed-batch culture of A. eutrophus produced 24 g of poly-beta-hydroxybutyric acid (PHB) liter-1 under ammonium limitation conditions. When the glucose feed was replaced with glucose and propionic acid during the polymer accumulation phase, 17 g of P(HB-co-HV) liter-1 was produced. The P(HB-co-HV) contained 5.0 mol% beta-hydroxyvaleric acid (HV). Varying the carbon-to-nitrogen ratio at a dilution rate of 0.15 h-1 in a chemostat culture of A. eutrophus resulted in a maximum value of 33% (wt/wt) PHB in the biomass. In comparison, A. latus accumulated about 40% (wt/wt) PHB in chemostat culture under nitrogen-limited conditions at the same dilution rate. When propionic acid was added to the first stage of a two-stage chemostat, A. latus produced 43% (wt/wt) P(HB-co-HV) containing 18.5 mol% HV. In the second stage, the P(HB-co-HV) increased to 58% (wt/wt) with an HV content of 11 mol% without further addition of carbon substrate. The HV composition in P(HB-co-HV) was controlled by regulating the concentration of propionic acid in the feed. Poly-beta-hydroxyalkanoates containing a higher percentage of HV were produced when pentanoic acid replaced propionic acid. PMID:2117877

  5. Beta-carotene as antioxidant

    NARCIS (Netherlands)

    Bast, A.; Plas, R.M. van der; Berg, H. van den; Haenen, G.R.M.M.

    1996-01-01

    Objective: Beta-carotene has been shown to exhibit a good radical-trapping antioxidant activity in vitro. We were interested to see if dietary β-carotene in combination with various intake levels for vitamin A would also inhibit lipid peroxidation. Design: Sixty male Wistar rats received vitamin A

  6. Beta Cell Workshop 2013 Kyoto

    DEFF Research Database (Denmark)

    Heller, R Scott; Madsen, Ole D; Nielsen, Jens Høiriis

    2013-01-01

    The very modern Kyoto International Conference Center provided the site for the 8th workshop on Beta cells on April 23-26, 2013. The preceding workshops were held in Boston, USA (1991); Kyoto, Japan (1994); Helsingør, Denmark (1997); Helsinki, Finland (2003); El Perello, Spain (2006); Peebles...

  7. Beta interferons in clinically isolated syndromes: a meta-analysis Interferons beta nas síndromes clínicas isoladas: meta-análise

    Directory of Open Access Journals (Sweden)

    Ailton Melo

    2008-03-01

    Full Text Available Beta-interferon use in definite multiple sclerosis (MS has been proven to modify clinical and magnetic resonance imaging outcome. We review and summarize the data of published double-blind, randomized clinical trials to assess, with a meta-analysis the safety and efficacy of beta-interferon on the occurrence of relapses in patients with a first clinical event suggestive of MS. After two years of follow-up, interferon beta decreased the risk of conversion to clinically definite MS 0.51[0.39-0.65], and delayed the time to diagnosis up to 367 days. Side-effects were mild and self limited. Our findings support the efficacy of early treatment with beta-interferon in reducing conversion to clinically defined MS in patients with clinically isolated syndromes.Já é suficientemente conhecido que a utilização de interferon beta modifica o prognóstico clínico e de ressonância magnética em pacientes com esclerose múltipla (EM. Revisamos e sumarizamos os dados dos ensaios clínicos, duplo-cegos, randomizados e controlados com placebos para analisar, através de meta-análise, a segurança e eficácia dos interferons-beta sobre a ocorrência de recidivas em pacientes com um primeiro evento clínico sugestivo de EM. Após dois anos de seguimento, os interferons-beta diminuíram o risco de conversão para EM clinicamente definida 0,51[0,39-0,65] e retardaram o tempo para diagnóstico em 367 dias. Os efeitos colaterais foram leves e auto limitados. Nossos dados comprovam a eficácia e segurança do interferon-beta em reduzir a conversão para EM clinicamente definida de pacientes com síndromes clínicas isoladas.

  8. Abstraction Mechanisms in the BETA Programming Language

    DEFF Research Database (Denmark)

    Kristensen, Bent Bruun; Madsen, Ole Lehrmann; Møller-Pedersen, Birger

    1983-01-01

    The BETA programming language is developed as part of the BETA project. The purpose of this project is to develop concepts, constructs and tools in the field of programming and programming languages. BETA has been developed from 1975 on and the various stages of the language are documented in [BETA...... a]. The application area of BETA is programming of embedded as well as distributed computing systems. For this reason a major goal has been to develop constructs that may be efficiently implemented. Furthermore the BETA language is intended to have a few number of basic but general constructs....... It is then necessary that the abstraction mechanisms are powerful in order to define more specialized constructs. BETA is an object oriented language like SIMULA 67 ([SIMULA]) and SMALLTALK ([SMALLTALK]). By this is meant that a construct like the SIMULA class/subclass mechanism is fundamental in BETA. In contrast...

  9. Neutron Beta Decay Studies with Nab

    CERN Document Server

    Baeßler, S.; Alonzi, L.P.; Balascuta, S.; Barrón-Palos, L.; Bowman, J.D.; Bychkov, M.A.; Byrne, J.; Calarco, J.R.; Chupp, T.; Cianciolo, T.V.; Crawford, C.; Frlež, E.; Gericke, M.T.; Glück, F.; Greene, G.L.; Grzywacz, R.K.; Gudkov, V.; Harrison, D.; Hersman, F.W.; Ito, T.; Makela, M.; Martin, J.; McGaughey, P.L.; McGovern, S.; Page, S.; Penttilä, S.I.; Počanić, D.; Rykaczewski, K.P.; Salas-Bacci, A.; Tompkins, Z.; Wagner, D.; Wilburn, W.S.; Young, A.R.

    2012-01-01

    Precision measurements in neutron beta decay serve to determine the coupling constants of beta decay and allow for several stringent tests of the standard model. This paper discusses the design and the expected performance of the Nab spectrometer.

  10. How Do Beta Blocker Drugs Affect Exercise?

    Science.gov (United States)

    ... Aneurysm More How do beta blocker drugs affect exercise? Updated:Aug 22,2017 Beta blockers are a ... about them: Do they affect your ability to exercise? The answer can vary a great deal, depending ...

  11. The beta subunit of casein kinase II

    DEFF Research Database (Denmark)

    Boldyreff, B; Piontek, K; Schmidt-Spaniol, I

    1991-01-01

    cDNAs encoding the beta subunit of pig and mouse CKII were isolated. The porcine cDNA was expressed as a fusion protein in Escherichia coli and used for the production of anti-CKII-beta subunit specific antibodies.......cDNAs encoding the beta subunit of pig and mouse CKII were isolated. The porcine cDNA was expressed as a fusion protein in Escherichia coli and used for the production of anti-CKII-beta subunit specific antibodies....

  12. Drug- and disease-induced changes of human cardiac beta 1- and beta 2-adrenoceptors

    NARCIS (Netherlands)

    Brodde, O. E.; Zerkowski, H. R.; Borst, H. G.; Maier, W.; Michel, M. C.

    1989-01-01

    Cardiac beta-adrenoceptor density and subtype distribution has been determined in different kinds of heart failure. A decrease in cardiac beta-adrenoceptor function appears to be a general phenomenon in all kinds of heart failure. However, cardiac beta 1- and beta 2-adrenoceptors seem to be

  13. Polypeptides having beta-glucosidase and beta-xylosidase activity and polynucleotides encoding same

    Science.gov (United States)

    Morant, Marc Dominique

    2014-05-06

    The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  14. Polypeptides having beta-glucosidase activity and beta-xylosidase activity and polynucleotides encoding same

    Energy Technology Data Exchange (ETDEWEB)

    Morant, Marc Dominique

    2014-05-06

    The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  15. Polypeptides having beta-glucosidase activity and beta-xylosidase activity and polynucleotides encoding same

    Energy Technology Data Exchange (ETDEWEB)

    Morant, Marc Dominique

    2014-04-29

    The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  16. THE ALPHA/BETA-HYDROLASE FOLD

    NARCIS (Netherlands)

    OLLIS, DL; CHEAH, E; CYGLER, M; FROLOW, F; FRANKEN, SM; HAREL, M; REMINGTON, SJ; SILMAN, [No Value; SCHRAG, J; SUSSMAN, JL; VERSCHUEREN, KHG; GOLDMAN, A

    We have identified a new protein fold-the alpha/beta-hydrolase fold-that is common to several hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of each enzyme is similar: an alpha/beta-sheet, not barrel, of eight beta-sheets connected by alpha-helices. These

  17. Beta-lactamases in Enterobacteriaceae in broilers

    NARCIS (Netherlands)

    Dierikx, C.M.

    2013-01-01

    Resistance to cephalosprins due to the production of extended spectrum beta-lactamases (ESBLs) or plasmid mediated AmpC beta-lactamases is increasingly found in infections in humans outside the hospital. The genes encoding for these beta-lactamases are located on mobile DNA (plasmids), which can be

  18. Clusters of conserved beta cell marker genes for assessment of beta cell phenotype

    DEFF Research Database (Denmark)

    Martens, Geert A; Jiang, Lei; Hellemans, Karine H

    2011-01-01

    The aim of this study was to establish a gene expression blueprint of pancreatic beta cells conserved from rodents to humans and to evaluate its applicability to assess shifts in the beta cell differentiated state. Genome-wide mRNA expression profiles of isolated beta cells were compared to those...... microdissected beta cells, monitor adaptations of the beta cell phenotype to fasting, and retrieve possible conserved transcriptional regulators....

  19. Composição centesimal e teor de beta-glucanas em cereais e derivados Nutrient profile and beta-glucans content in cereal seeds and foodstuffs contain them

    Directory of Open Access Journals (Sweden)

    Alexandre H. Fujita

    2003-08-01

    Full Text Available Foi utilizado o método enzimático recomendado pela AOAC para determinação de beta-glucanas em cereais e alimentos que os contém. O método, utiliza liquenase (EC 3.2.1.73 e beta-glucosidase (EC 3.2.1.21 para hidrólise debeta-glucanas, é rápido, fácil de executar e específico para beta-glucanas com ligações beta(1->3 e beta(1->4. As sementes analisadas foram subministradas pelo Instituto Agronômico de Campinas (IAC e os alimentos adquiridos nos supermercados. Aveia e cevada são os grãos com maior conteúdo de beta-glucanas. Na aveia os teores determinados foram 6,48 e 5,94%. Nos 10 cultivares de cevada os teores de beta-glucanas oscilaram entre 2,04 e 9,68%. Trigo e triticale apresentaram teores de b-glucanas menores que 1%. Nos produtos comerciais o teor de beta-glucanas estava relacionado ao tipo de cereal da fórmula. O produto comercial de maior conteúdo de beta-glucanas é o farelo de aveia. As beta-glucanas são ingredientes funcionais em potencial e a conveniência ou não de estimular sua incorporação em alimentos deve ser mais estudada. Quanto à composição centesimal dos grãos de cereais, o teor de proteínas foi o que apresentou a maior variação e isso se reflete na composição dos produtos comerciais.The method employed was the enzymatic one recommended by de AOAC for the determination of beta-glucans in cereals and in foodstuffs containing cereals in their formulation. The method, using lichenase (EC 3.2.1.73 and beta-glucosidase (EC 3.2.1.21 for the hydrolysis of beta-glucans, is quick and easy to execute, but is specific for beta-glucans with beta(1->3 and beta(1->4 bonds. The Agronomic Institute of Campinas (IAC supplied the seeds analyzed, and the foodstuffs were acquired in supermarkets. Oat and barley are the grains with the highest content of beta-glucans. In the oats, the determined values were 6.48 and 5.94%. In the 10 cultivars of barley, the content of beta-glucans varied between 2.04 and 9

  20. Specific Triazine Herbicides Induce Amyloid-beta(42) Production

    NARCIS (Netherlands)

    Portelius, Erik; Durieu, Emilie; Bodin, Marion; Cam, Morgane; Pannee, Josef; Leuxe, Charlotte; Mabondzo, Aloise; Oumata, Nassima; Galons, Herve; Lee, Jung Yeol; Chang, Young-Tae; Stuber, Kathrin; Koch, Philipp; Fontaine, Gaelle; Potier, Marie-Claude; Manousopoulou, Antigoni; Garbis, Spiros D.; Covaci, Adrian; Van Dam, Debby; De Deyn, Peter; Karg, Frank; Flajolet, Marc; Omori, Chiori; Hata, Saori; Suzuki, Toshiharu; Blennow, Kaj; Zetterberg, Henrik; Meijer, Laurent

    2016-01-01

    Proteolytic cleavage of the amyloid-beta protein precursor (A beta PP) ecretases leads to extracellular release of amyloid-beta (A beta) peptides. Increased production of A beta(42) over A beta(40) and aggregation into oligomers and plaques constitute an Alzheimer's disease (AD) hallmark.

  1. Two new beta-strand mimics.

    Science.gov (United States)

    Tsai, J H; Waldman, A S; Nowick, J S

    1999-01-01

    In a previous report, Nowick and co-workers described beta-strand mimic A, which duplicates the structure and hydrogen-bonding pattern of one edge of a tetrapeptide in a beta-strand conformation (Nowick, J. S.; Pairish, M.; Lee, I. Q.; Holmes, D. L.; Ziller, J. W. J. Am. Chem. Soc. 1997, 119, 5413). Beta-strand mimic A is composed of a 5-amino-2-methoxybenzoic acid unit linked to a 5-hydrazino-2-methoxybenzamide unit by means of an acylhydrazine group. This paper introduces two related beta-strand mimics (B and C) and reports their comparison to beta-strand mimic A. Beta-strand mimic B is composed of a 5-amino-2-methoxybenzoic acid unit linked by a diacylhydrazine group to a fumaramide unit; beta-strand mimic C is composed of a 5-amino-2-methoxybenzoic acid unit linked by a diacylhydrazine group to a peptide. Beta-strand mimics A-C were connected to tripeptide (Phe-Ile-Leu) groups by means of 1,2-diaminoethane diurea turn units to form artificial beta-sheets 1-3. 1H NMR studies, involving ROESY, chemical shift, coupling constant, and variable temperature experiments, reveal that 1-3 adopt hydrogen-bonded antiparallel beta-sheet conformations and establish that all three templates are viable beta-strand mimics.

  2. Beta-blocking agents with vasodilating action.

    Science.gov (United States)

    Prichard, B N

    1992-01-01

    beta-Adrenoceptor-blocking drugs in current use can be separated into two main groups: those nonselective and those selective for beta 1-receptors. Members of each group reduce cardiac output and lead to an increase in peripheral resistance with a concomitant reduction in blood flow. beta-Blocking drugs not only may occupy the receptor preventing stimulation but also may have intrinsic sympathomimetic activity. Those with marked partial agonist activity at the beta 2-receptor giving some beta 2-mediated vasodilation can be regarded as the first multiple-action beta-blocking drugs. Subsequently, drugs have been developed that in addition to blocking the beta-receptor have an important peripheral vasodilator activity. Labetalol was the first drug of this group to be developed; prizidolol followed but has been withdrawn because of toxicity. Several other agents have been described, including bucindolol, carvedilol, celiprolol, dilevalol (one of the isomers of labetalol), and medroxolol. Three mechanisms have been reported to be responsible for peripheral vasodilation: alpha-receptor blockade, beta 2-agonism, and a dilator action independent of either the alpha- or beta-receptors. Evidence for these various mechanisms is more readily obtainable from animal experiments, but some confirmatory evidence has been obtained in humans. Inhibition of alpha-stimulation had been found with labetalol, medroxalol, and carvedilol and suggested with celiprolol. beta 2-Mediated vasodilation has been demonstrated by, for example, celiprolol and dilevalol; evidence of a vasodilation independent of alpha-blockade or beta 2-stimulation has been reported with celiprolol and carvedilol.

  3. Beta-thalassemia in Turkey.

    Science.gov (United States)

    Oner, R; Altay, C; Gurgey, A; Aksoy, M; Kilinç, Y; Stoming, T A; Reese, A L; Kutlar, A; Kutlar, F; Huisman, T H

    1990-01-01

    A review is presented of the various beta-thalassemia alleles observed in nearly 191 patients with beta-thalassemia major and their 182 heterozygous relatives. Determination was by gene amplification and dot-blot hybridization with synthetic probes, specific for 27 different mutations. Eighteen mutations have been observed; six of these account for nearly 83% of all thalassemia abnormalities. A new mutation, i.e. a G----C mutation at the acceptor splice site of IVS-I, was found in one teenager who was homozygous for this disease. The high consanguinity among the families was considered the main reason for the high number of patients with a homozygosity for the IVS-I-110 (G----A) mutation. Combinations of different mutations were present in many patients; some were mildly affected because of the specific mutation present on one chromosome. Combinations of classical beta-thalassemia and an abnormal hemoglobin mainly concerned Hb S. Hbs Knossos and Lepore were rare occurrences. A comparison of hematological data for adults with heterozygosities for some of the common alleles confirmed the low Hb A2 values in IVS-I-6 (T----C) heterozygotes and the high Hb F values for codon 8 (-AA), IVS-II-1 (G----A), and IVS-I-1 (G----A) heterozygotes.

  4. TOPICAL REVIEW: Double beta decay

    Science.gov (United States)

    Faessler, Amand; Simkovic, Fedor

    1998-12-01

    We review the recent developments in the field of nuclear double beta decay, which is presently an important topic in both nuclear and particle physics. The mechanism of lepton number violation within the neutrinoless double beta decay (0954-3899/24/12/001/img5-decay) is discussed in the context of the problem of neutrino mixing and the R-parity violating supersymmetric extensions of the standard model. The problem of reliable determination of the nuclear matrix elements governing both two-neutrino and neutrinoless modes of the double beta decay is addressed. The validity of different approximation schemes in the considered nuclear structure studies is analysed and the role of the Pauli exclusion principle for a correct treatment of nuclear matrix elements is emphasized. The constraints on different lepton-number violating parameters such as effective electron neutrino mass, effective right-handed weak interaction parameters, effective Majoron coupling constant and R-parity violating SUSY parameters are derived from the best presently available experimental limits on the half-life of 0954-3899/24/12/001/img5-decay.

  5. Impacto do uso da prova rápida para estreptococo beta-hemolítico do grupo A no diagnóstico e tratamento da faringotonsilite aguda em pronto-socorro de Pediatria Impacto del uso de la prueba rápida para estreptococos beta-hemolíticos del grupo A en el diagnóstico y tratamiento de la faringotonsilitis en emergencia de Pediatría Impact of the rapid antigen detection test in diagnosis and treatment of acute pharyngotonsillitis in a Pediatric emergency room

    Directory of Open Access Journals (Sweden)

    Débora Morais Cardoso

    2013-03-01

    Full Text Available OBJETIVO: Avaliar o impacto da realização rotineira da prova rápida para pesquisa de estreptococo do grupo A no diagnóstico e tratamento da faringotonsilite aguda em crianças. MÉTODOS: Estudo prospectivo e observacional que contou com a utilização de protocolo de pesquisa estabelecido na Unidade de Emergência do Hospital Universitário da Universidade de São Paulo para o atendimento de crianças e adolescentes com faringotonsilite aguda. RESULTADOS: Com base na avaliação clínica, dos 650 pacientes estudados, antimicrobianos seriam prescritos para 389 indivíduos (59,8% e, com o uso da pesquisa de estreptococo do grupo A, foram prescritos em 286 pacientes (44,0%. Das 261 crianças que não receberiam antibiótico pelo quadro clínico, 111 (42,5% tiveram pesquisa de estreptococo do grupo A positiva. O diagnóstico baseado no quadro clínico apresentou sensibilidade de 61,1%, especificidade de 47,7%, valor preditivo positivo de 44,9% e valor preditivo negativo de 57,5%. CONCLUSÕES: O diagnóstico clínico da faringotonsilite estreptocócica mostrou baixa sensibilidade e especificidade. O uso rotineiro da prova rápida para pesquisa de estreptococo permitiu a redução do uso de antibióticos e a identificação de um grupo de risco para as complicações da infecção estreptocócica, pois 42,5% dos pacientes com prova rápida positiva não receberiam antibióticos, se levado em consideração apenas o diagnóstico clínico.OBJETIVO: Evaluar el impacto de la realización de rutina de la prueba rápida para investigación de estreptococos del grupo A en el diagnóstico y tratamiento de la faringotonsilitis aguda en niños. MÉTODOS: Estudio prospectivo y observacional que contó con el uso de protocolo de investigación establecido en la Unidad de Emergencia del Hospital Universitario de la USP para la atención a niños y adolescentes con faringotonsilitis aguda. RESULTADOS: Con base en la evaluación crítica, de los 650 pacientes

  6. Niveles plasmáticos de beta-endorfina en el ciclo menstrual y en la dismenorrea

    OpenAIRE

    Martínez-Guisasola Campa, Francisco Javier

    1993-01-01

    Se realiza la valoración de las concentraciones plasmáticas de beta-endorfina en el ciclo menstrual y en la mujer dismenorreica, para lo que se estudian un grupo de jóvenes fértiles, todas ellas voluntarias, no estando ninguna sometida a tratamiento hormonal ni a anticoncepción. La sangre obtenida en días concretos del ciclo por punción venosa es analizada por RIA para obtener las concentraciones del opiáceo, determinándose las gonadotropinas y los esteroides ováricos por ELISA. La beta-endor...

  7. Conversion of beta-methylbutyric acid to beta-hydroxy-beta-methylbutyric acid by Galactomyces reessii.

    Science.gov (United States)

    Lee, I Y; Nissen, S L; Rosazza, J P

    1997-11-01

    beta-Hydroxy-beta-methylbutyric acid (HMB) has been shown to increase strength and lean mass gains in humans undergoing resistance-exercise training. HMB is currently marketed as a calcium salt of HMB, and thus, environmentally sound and inexpensive methods of manufacture are being sought. This study investigates the microbial conversion of beta-methylbutyric acid (MBA) to HMB by cultures of Galactomyces reessii. Optimal concentrations of MBA were in the range of 5 to 20 g/liter for HMB production. Preliminary shake flask experiments indicated that HMB yields were sensitive to dissolved oxygen levels and that cell growth decreased significantly as MBA concentrations increased. Degradation of HMB was faster at acidic pH, and pH 7.0 was optimal for HMB production. Resting cells obtained from media without MBA could efficiently convert MBA to HMB. Thus, a two-step, fed-batch fermentation procedure in which biomass was first produced, followed by coaddition of MBA and glucose, while dissolved oxygen was maintained at 20% of saturation, was designed. A maximum HMB concentration of 38 g/liter was obtained after 136 h, and the molar conversion yield was more than 0.50 mol of HMB/mol of MBA during the fermentation.

  8. Crecimiento de Plantas de Remolacha (Beta vulgaris L. var. Crosby Egipcia) Bajo Coberturas de Color Growth of Beet (Beta vulgaris L. var. Crosby Egipcia) under Colored Covers

    OpenAIRE

    Fánor Casierra-Posada; José Rogelio Pinto-Correa

    2011-01-01

    La respuesta de las plantas a diferente color en la iluminación, se atribuye a fotorreceptores que conducen a diversas expresiones fenotípicas en diferentes niveles y etapas del desarrollo vegetal. Para determinar si el color de iluminación en que se cultivan las plantas de remolacha (Beta vulgaris L. var. Crosby Egipcia), afecta su crecimiento, rendimiento y calidad, se realizó en Duitama -; Colombia, un estudio bajo coberturas de color azul, rojo o transparente. Para conseguir los colores s...

  9. Measurement of dose equivalent with personal dosemeters and instrumentation of radiological protection in the new operative magnitudes ICRU, for external fields of radiation beta. Part IV. Survey of the angular response of instruments used in radiological protection in secondary patron fields of beta radiation ({sup 90}Sr/{sup 90}Y (1850 MBq and 74 MBq), {sup 204}TI (18.5 MBq) and {sup 147}Pm (518 MBq)); Medicion de dosis equivalente con dosimetros personales e instrumentacion de proteccion radiologica en las nuevas magnitudes operativas ICRU, para campos de radiacion beta externos. Parte IV. Estudio de la respuesta angular de instrumentos empleados en proteccion radiologica en campos patrones secundarios de radiacion beta ({sup 90}Sr/{sup 90}Y (1850 MBq y 74 MBq), {sup 204}TI (18.5 MBq) y {sup 147}Pm(518 MBq))

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, J.T. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1994-02-15

    Tests type were made (type test) in the following commercial instrumentation commonly used in radiological protection: Geiger-Mueller Counters (FH40 FE), Plastic Scintillators (NE-BP/6/4A), Ionization Chambers (RO-5) and Proportional Counters (HP-100A; gas:P-10). With object of checking the possibility that these they can carry out the new operative unit ICRU, H' (0.07; {alpha}). The tests consisted on determining the energy and angular response of the detectors in secondary patron fields of beta radiation, for isotopes of {sup 90}Sr/{sup 90}Y (1850 MBq and 74 MBq and {sup 147}Pm(518 MBq). The results show the inadequate of these commercial instruments for the realization of the H' operative unit (0.07; {alpha}) in beta external fields. Due to flaws in the design, construction and calibration of the instruments for this type of radiation fields (Author)

  10. Characterization of a beta-N-acetylhexosaminidase and a beta-N-acetylglucosaminidase/beta-glucosidase from Cellulomonas fimi.

    Science.gov (United States)

    Mayer, Christoph; Vocadlo, David J; Mah, Melanie; Rupitz, Karen; Stoll, Dominik; Warren, R A J; Withers, Stephen G

    2006-07-01

    The gram-positive soil bacterium Cellulomonas fimi is shown to produce at least two intracellular beta-N-acetylglucosaminidases, a family 20 beta-N-acetylhexosaminidase (Hex20), and a novel family 3-beta-N-acetylglucosaminidase/beta-glucosidase (Nag3), through screening of a genomic expression library, cloning of genes and analysis of their sequences. Nag3 exhibits broad substrate specificity for substituents at the C2 position of the glycone: kcat/Km values at 25 degrees C were 0.066 s(-1) x mM(-1) and 0.076 s(-1) x mM(-1) for 4'-nitrophenyl beta-N-acetyl-D-glucosaminide and 4'-nitrophenyl beta-D-glucoside, respectively. The first glycosidase with this broad specificity to be described, Nag3, suggests an interesting evolutionary link between beta-N-acetylglucosaminidases and beta-glucosidases of family 3. Reaction by a double-displacement mechanism was confirmed for Nag3 through the identification of a glycosyl-enzyme species trapped with the slow substrate 2',4'-dinitrophenyl 2-deoxy-2-fluoro-beta-D-glucopyranoside. Hex20 requires the acetamido group at C2 of the substrate, being unable to cleave beta-glucosides, since its mechanism involves an oxazolinium ion intermediate. However, it is broad in its specificity for the D-glucosyl/D-galactosyl configuration of the glycone: Km and kcat values were 53 microM and 482.3 s(-1) for 4'-nitrophenyl beta-N-acetyl-D-glucosaminide and 66 microM and 129.1 s(-1) for 4'-nitrophenyl beta-N-acetyl-D-galactosaminide.

  11. Bovine haemoglobin beta A Zebu, beta A43(CD3)Ser----Thr: an intermediate globin type between the beta A and beta D Zambia is present in Indian zebu cattle.

    Science.gov (United States)

    Namikawa, T; Nagai, A; Takenaka, O; Takenaka, A

    1987-01-01

    Two bovine haemoglobin beta chains, electrophoretically identical with the beta A chain of Herefords, were obtained from Ongole and Banteng, Bos javanicus, cattle. The amino acid residue differences of the two beta chains were compared by electrophoresis, cation-exchange and reverse-phase chromatography, amino acid analyses, and Edman degradation in comparison with beta A chain. The results showed that two beta chains differed from the beta A chain of the Hereford breed by the substitution of serine with threonine at the beta 43 position. No other difference was found between the two chains and beta A. This new beta chain type was termed beta A Zebu, which forms a possible evolutionarily transitional type between the beta A and the rare variant beta D Zambia found previously in African zebu cattle. The beta A Zebu differentiates from the previous beta B by at least four amino acid substitutions involving five codon-base changes.

  12. Are we misunderstanding beta-blockers.

    Science.gov (United States)

    Cruickshank, J M

    2007-08-09

    In myocardial ischaemia and heart failure, beta-blockers with intrinsic sympathomimetic activity (ISA) e.g. pindolol, xamoterol, bucindolol, nebivolol, have performed poorly in reducing morbidity and mortality. In both indications beta-1 blockade is the vital active ingredient. Beta-1 blockade (bisoprolol) is now an alternative first-line choice to Ace-inhibition in the treatment of heart failure. The therapeutic role of beta-blockers in hypertension is less well understood, particularly since the new recommendations in the UK from the NICE committee stating that: 1. beta-blockers are no longer preferred as a routine initial therapy, 2. the combination with diuretics is discouraged due to the risk of induced diabetes, and 3. in younger patients first-choice initial therapy should be an ACE-inhibitor. Recent data from the Framingham Heart Study and other epidemiological studies have indicated that the development of diastolic hypertension in younger subjects is closely linked to weight-increase and an increase in peripheral resistance; such subjects have a high adrenergic drive and cardiac output. In contrast, elderly systolic hypertension mostly arises de novo via poor vascular compliance. Thus in younger, probably overweight, hypertensives (including diabetics) first-line beta-blockade has performed well in preventing myocardial infarction (a fact hidden by meta-analyses that do not take age into account). Conversely, in elderly hypertensives first-line beta-blockade (atenolol) has performed poorly in reducing cardiovascular risk (due to partial beta-2 blockade atenolol evokes metabolic disturbance and does not improve vascular compliance, or effectively lower central aortic pressure or reverse left ventricular hypertrophy). Thus beta-blockers like atenolol are ill-equipped for first-line therapy in elderly hypertension. Some beta-blockers, e.g. bisoprolol (up to 10 mg/day is highly beta-1 selective) and nebivolol (beta-2/3 intrinsic sympathomimetic activity), do

  13. Resistance training & beta-hydroxy-beta-methylbutyrate supplementation on hormones

    Directory of Open Access Journals (Sweden)

    Hamid Arazi

    2015-10-01

    Full Text Available RESUMOIntroduction:In recent years, there was an increased interest on the effects of beta-hydroxy-beta-methylbutyrate (HMB supplementation on skeletal muscle due to its anti-catabolic effects.Objectives:To investigate the effect of HMB supplementation on body composition, muscular strength and anabolic-catabolic hormones after resistance training.Methods:Twenty amateur male athletes were randomly assigned to supplement and control groups in a double-blind crossover design and participated in four weeks resistance training. Before and after the test period fasting blood samples were obtained to determine anabolic (the growth hormone and testosterone and catabolic (cortisol hormones, and fat mass, lean body mass (LBM and muscular strength were measured. Dependent and independent t-tests were used to analyze data.Results:After the training period, there were no significant differen-ces between the groups with respect to fat mass, LBM and anabolic-catabolic hormones. HMB supplementation resulted in a significantly greater strength gain (p≤0.05.Conclusion:Greater increase in strength for HMB group was not accompanied by body composition and basal circulating anabolic-catabolic hormonal changes. It seems that HMB supplementation may have beneficial effects on neurological adaptations of strength gain.

  14. [Beta thalassemia major in Argentina].

    Science.gov (United States)

    Torres, Feliu Aurora; Bonduel, Mariana; Sciuccati, Gabriela; del Pozo, Ana; Roldán, Ariel; Ciaccio, Marta; Orazi, Virginia; Fano, Virginia; Ozuna, Blanca; Lejarraga, Horacio; Muriel, Sackmann Federico

    2002-01-01

    An analysis of beta thalassemia major patients seen at Hospital Juan P. Garrahan was carried out in order to determine the characteristics and outcome of the population. From August 1987 to July 2000, 45 patients were admitted (27 males-18 females). The most common beta globin gene defects were C-39 (30.7%); IVS-I nt 110 (20%); IVS-I nt 6 (13.3%); IVS-I nt 1(4%). alpha globin genes were normal in 42 patients, 1 patient had triplicate and cuadriplicate alpha globin genes and 2 patients were not analyzed. Six patients of 5 families were heterozygous for -158G gamma mutation. Allogeneic stem cell transplantation was performed in 7 patients, with an identical sibling. Transfusion-related infections and alloantibodies were detected in 6.7% patients. Growth assessment showed no significant difference in the stature of girls compared to the reference population, but 5 boys had short stature. There is a tendency to short trunk. Growth velocity was normal at prepubertal age. No X-ray lesions related to desferrioxamine were observed. Delayed puberty and hypogonadotropic hypogonadism were found in 35.7% and abnormalities in GH/IGF-I axis in 12.5% of the patients. Impaired glucose tolerance was found in 2 patients. No patient developed diabetes mellitus, thyroid or adrenal insufficiency. One patient had cardiac complications. Forty-two patients are alive and 3 died (cardiac failure 1, central nervous system bleeding 1, sepsis 1). We conclude that beta thalassemia major, originated mainly from Italian immigrants, has a cumbersome treatment and is severely hindered by the lack of adequate economic resources in our patients.

  15. Binding of TEM-1 beta-lactamase to beta-lactam antibiotics by frontal affinity chromatography.

    Science.gov (United States)

    Chen, Xiu; Li, Yuhua; Zhang, Yan; Yang, Jianting; Bian, Liujiao

    2017-04-15

    TEM-1 beta-lactamases can accurately catalyze the hydrolysis of the beta-lactam rings in beta-lactam antibiotics, which make beta-lactam antibiotics lose its activity, and the prerequisite for the hydrolysis procedure in the binding interaction of TEM-1 beta-lactamases with beta-lactam antibiotics is the beta-lactam rings in beta-lactam antibiotics. Therefore, the binding of TEM-1 beta-lactamase to three beta-lactam antibiotics including penicillin G, cefalexin as well as cefoxitin was explored here by frontal affinity chromatography in combination with fluorescence spectra, adsorption and thermodynamic data in the temperature range of 278-288K under simulated physiological conditions. The results showed that all the binding of TEM-1 beta-lactamase to the three antibiotics were spontaneously exothermic processes with the binding constants of 8.718×103, 6.624×103 and 2.244×103 (mol/L), respectively at 288K. All the TEM-1 beta-lactamases were immobilized on the surface of the stationary phase in the mode of monolayer and there existed only one type of binding sites on them. Each TEM-1 beta-lactamase bound with only one beta-lactam antibiotic and hydrogen bond interaction and Van der Waals force were the main forces between them. This work provided an insight into the binding interactions between TEM-1 beta-lactamases and beta-lactam antibiotics, which may be beneficial for the designing and developing of new substrates resistant to TEM-1 beta-lactamases. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Metabolic signalling in pancreatic beta cells

    OpenAIRE

    Piipari, K.

    2011-01-01

    The main function of pancreatic beta cells is to maintain correct glucose homeostasis within the body by secretion of insulin in response to increased blood glucose concentration. Beta cell dysfunction contributes to the pathogenesis of diabetes. Using transgenic mouse models, the work described in this thesis has investigated the role of AMP-activated protein kinase (AMPK) and phosphatidylinositol 3-kinase (PI3K) in beta cell function and their role in the regulation of ...

  17. NMR Spectroscopic Analysis on the Chiral Recognition of Noradrenaline by {beta}-Cyclodextrin ({beta}-CD) and Carboxymethyl- {beta}-cyclodextrin (CM- {beta}-CD)

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Hoo; Yi, Dong Heui; Jung, Seun Ho [Konkuk University, Seoul (Korea, Republic of)

    2004-02-15

    {beta}-CD and CM-{beta}-CD as chiral NMR shift agents were used to resolve the enantiomers of noradrenaline (NA). The stoichiometry of each complex formed between the CDs and the enantiomers of NA was found to be 1 : 1 through the continuous variation plots. The binding constants (K) of the complexes were determined from 1H NMR titration curves. This result indicated that both {beta}-CD and CM-{beta}-CD formed the complexes with the S (+)-NA more preferentially than its R(.)-enantiomer. The K values for the complexes with {beta}-CD (KS(+) = 537 M{sup -1} and K{sub R}({sub -}) = 516 M{sup -1}) was larger than those with CM-{beta}-CD (K{sub S}({sub +}) = 435 M{sup -1} and K{sub R}({sub -}) = 313 M{sup -1}), however, enantioselectivity ({alpha}) of S({sub +})- and R(-)-NA to CM-{beta}-CD ({alpha} = 1.38) was larger than that to {beta}-CD ({alpha} = 1.04), indicating that CM-{beta}-CD was the better chiral NMR solvating agents for the recognition of the enantiomers of NA. Two dimensional rotating frame nuclear Overhauser enhancement spectroscopy (ROESY) experiments were also performed to explain the binding properties in terms of spatial fitting of the NA molecule into the macrocyclic cavities

  18. Milk Intolerance, Beta-Casein and Lactose.

    Science.gov (United States)

    Pal, Sebely; Woodford, Keith; Kukuljan, Sonja; Ho, Suleen

    2015-08-31

    True lactose intolerance (symptoms stemming from lactose malabsorption) is less common than is widely perceived, and should be viewed as just one potential cause of cows' milk intolerance. There is increasing evidence that A1 beta-casein, a protein produced by a major proportion of European-origin cattle but not purebred Asian or African cattle, is also associated with cows' milk intolerance. In humans, digestion of bovine A1 beta-casein, but not the alternative A2 beta-casein, releases beta-casomorphin-7, which activates μ-opioid receptors expressed throughout the gastrointestinal tract and body. Studies in rodents show that milk containing A1 beta-casein significantly increases gastrointestinal transit time, production of dipeptidyl peptidase-4 and the inflammatory marker myeloperoxidase compared with milk containing A2 beta-casein. Co-administration of the opioid receptor antagonist naloxone blocks the myeloperoxidase and gastrointestinal motility effects, indicating opioid signaling pathway involvement. In humans, a double-blind, randomized cross-over study showed that participants consuming A1 beta-casein type cows' milk experienced statistically significantly higher Bristol stool values compared with those receiving A2 beta-casein milk. Additionally, a statistically significant positive association between abdominal pain and stool consistency was observed when participants consumed the A1 but not the A2 diet. Further studies of the role of A1 beta-casein in milk intolerance are needed.

  19. MOPITT Beta Level 1 Radiances V107

    Data.gov (United States)

    National Aeronautics and Space Administration — The MOPITT Beta Level 1 data product consists of the geolocated, calibrated earth scene radiances, associated instrument engineering data summaries, and inflight...

  20. Milk Intolerance, Beta-Casein and Lactose

    Directory of Open Access Journals (Sweden)

    Sebely Pal

    2015-08-01

    Full Text Available True lactose intolerance (symptoms stemming from lactose malabsorption is less common than is widely perceived, and should be viewed as just one potential cause of cows’ milk intolerance. There is increasing evidence that A1 beta-casein, a protein produced by a major proportion of European-origin cattle but not purebred Asian or African cattle, is also associated with cows’ milk intolerance. In humans, digestion of bovine A1 beta-casein, but not the alternative A2 beta-casein, releases beta-casomorphin-7, which activates μ-opioid receptors expressed throughout the gastrointestinal tract and body. Studies in rodents show that milk containing A1 beta-casein significantly increases gastrointestinal transit time, production of dipeptidyl peptidase-4 and the inflammatory marker myeloperoxidase compared with milk containing A2 beta-casein. Co-administration of the opioid receptor antagonist naloxone blocks the myeloperoxidase and gastrointestinal motility effects, indicating opioid signaling pathway involvement. In humans, a double-blind, randomized cross-over study showed that participants consuming A1 beta-casein type cows’ milk experienced statistically significantly higher Bristol stool values compared with those receiving A2 beta-casein milk. Additionally, a statistically significant positive association between abdominal pain and stool consistency was observed when participants consumed the A1 but not the A2 diet. Further studies of the role of A1 beta-casein in milk intolerance are needed.

  1. Beta blockers: A new role in chemotherapy

    Science.gov (United States)

    Nagaraja, Archana S; Sadaoui, Nouara C.; Lutgendorf, Susan K.; Ramondetta, Lois M.; Sood, Anil K.

    2014-01-01

    Beta-blockers are a class of drugs widely used to treat cardiac, respiratory and other ailments. They act by blocking beta-adrenergic receptor–mediated signalling. Studies in various cancers have shown that patients taking a beta-blocker have higher survival and lower recurrence and metastasis rates. This is supported by several preclinical and in vitro studies showing that adrenergic activation modulates apoptosis, promotes angiogenesis and other cancer hallmarks, and these effects can be abrogated by beta-blockers. These studies provide a rationale for the use of beta-blockers as adjuvants with cancer chemotherapy. However, all published studies so far are retrospective, and most do not take into account the specific beta-blocker used or address which is most likely to benefit cancer patients. The published epidemiological studies are correlative and have not examined the adrenergic receptor status of the tumours. Knowledge of the beta-adrenergic receptor status of tumour cells is essential in choosing the best beta-blocker for adjuvant therapy. A comprehensive, prospective study is necessary to prove definitively the utility of using beta-blockers with chemotherapy and to identify the specific betablocker most likely to benefit patients with cancer. PMID:23919278

  2. $\\beta$-decay study of $^{77}$Cu

    CERN Document Server

    Patronis, N; Górska, M; Huyse, M; Kruglov, K; Pauwels, D; Van de Vel, K; Van Duppen, P; Van Roosbroeck, J; Thomas, J-C; Franchoo, S; Cederkäll, J; Fedosseev, V; Fynbo, H; Georg, U; Jonsson, O; Köster, U; Materna, T; Mathieu, L; Serot, O; Weissman, L; Müller, W F; Mishin, V I; Fedorov, D

    2009-01-01

    A beta-decay study of Cu-77 has been performed at the ISOLDE mass separator with the aim to deduce its beta-decay properties and to obtain spectroscopic information on Zn-77. Neutron-rich copper isotopes were produced by means of proton- or neutron-induced fission reactions on U-238. After the production, Cu-77 was selectively laser ionized, mass separated and sent to different detection systems where beta-gamma and beta-n coincidence data were collected. We report on the deduced half-live, decay scheme, and possible spin assignment of 77Cu.

  3. Sawtooth crashes at high beta on JET

    Energy Technology Data Exchange (ETDEWEB)

    Alper, B.; Huysmans, G.T.A.; Sips, A.C.C. [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking; Nave, M.F.F. [Universidade Tecnica, Lisbon (Portugal). Inst. Superior Tecnico

    1994-07-01

    The sawtooth crashes on JET display features which depend on beta. The main observation is a transient bulging of flux surfaces (duration inferior to 30 microsec.), which is predominantly on the low field side and extends to larger radii as beta increases. This phenomenon reaches the plasma boundary when beta{sub N} exceeds 0.5 and in these cases is followed by an ELM within 50 microsec. These sawtooth/ELM events limit plasma performance. Modelling of mode coupling shows qualitative agreement between observations of the structure of the sawtooth precursor and the calculated internal kink mode at high beta. (authors). 6 refs., 5 figs.

  4. Challenges in Double Beta Decay

    Directory of Open Access Journals (Sweden)

    Oliviero Cremonesi

    2014-01-01

    Full Text Available In the past ten years, neutrino oscillation experiments have provided the incontrovertible evidence that neutrinos mix and have finite masses. These results represent the strongest demonstration that the electroweak Standard Model is incomplete and that new Physics beyond it must exist. In this scenario, a unique role is played by the Neutrinoless Double Beta Decay searches which can probe lepton number conservation and investigate the Dirac/Majorana nature of the neutrinos and their absolute mass scale (hierarchy problem with unprecedented sensitivity. Today Neutrinoless Double Beta Decay faces a new era where large-scale experiments with a sensitivity approaching the so-called degenerate-hierarchy region are nearly ready to start and where the challenge for the next future is the construction of detectors characterized by a tonne-scale size and an incredibly low background. A number of new proposed projects took up this challenge. These are based either on large expansions of the present experiments or on new ideas to improve the technical performance and/or reduce the background contributions. In this paper, a review of the most relevant ongoing experiments is given. The most relevant parameters contributing to the experimental sensitivity are discussed and a critical comparison of the future projects is proposed.

  5. Synthesis, binding affinity and selectivity of new beta 1- and beta 2-adrenoceptor blockers.

    Science.gov (United States)

    Brizzi, V; Francioli, M; Brufani, M; Filocamo, L; Bruni, G; Massarelli, P

    1999-01-01

    The synthesis of a new series of sesamol derivatives with beta-adrenergic blocking activity is described. The affinity and selectivity of these compounds for beta 1- and beta 2-adrenoceptors were studied in comparison with those of ICI-118551 and propranolol. Some of the synthesized compounds show very good affinity for the beta 2-receptors of rat lung membranes and two of them provide interesting selectivity.

  6. Enzyme analyses demonstrate that beta-methylbutyric acid is converted to beta-hydroxy-beta-methylbutyric acid via the leucine catabolic pathway by galactomyces reessii

    Science.gov (United States)

    Lee; Rosazza

    1998-03-01

    Galactomyces reessii accomplishes the enzymatic transformation of beta-methylbutyric acid (isovaleric acid) to beta-hydroxy-beta-methylbutyric acid. The enzymatic basis for this bioconversion was evaluated by analyzing cell-free extracts of G. reessii for enzyme activities commonly associated with leucine catabolism. G. reessii extracts contained activities for acyl-CoA synthetase, acyl-CoA dehydrogenase, and enoyl-CoA hydratase, whereas beta-methylbutyric acid hydroxylase, alpha-ketoisocaproate oxygenase, and acyl-CoA oxidase (with isovaleryl-CoA as substrate) were not observed. Furthermore, beta-methylbutyric acid is initially activated to isovaleryl-CoA by acyl-CoA synthetase, dehydrogenated to methylcrotonyl-CoA by acyl-CoA dehydrogenase, hydrated to beta-hydroxy-beta-methylbutyric acid-CoA by enoyl-CoA hydratase, and hydrolyzed to beta-hydroxy-beta-methylbutyric acid in G. reessii extracts. Cell-free extracts converted both isovaleryl-CoA and methylcrotonyl-CoA into beta-hydroxy-beta-methylbutyric acid, thus demonstrating that beta-methylbutyric acid is part of the leucine catabolic pathway. The rate of beta-methylbutyric acid conversion to beta-hydroxy-beta-methylbutyric acid with cell-free extract was 0. 013 &mgr;mol beta-hydroxy-beta-methylbutyric acid (mg protein)-1 h-1, while the conversion rate of leucine was fivefold lower. With whole cells, the highest production rate [0.042 &mgr;mol beta-hydroxy-beta-methylbutyric acid (g cells)-1 h-1] was also observed with beta-methylbutyric acid. The results indicate that beta-methylbutyric acid is transformed to beta-hydroxy-beta-methylbutyric acid through the leucine catabolic pathway.

  7. Isotope Effects in the Bonds of beta-CrOOH and beta-CrOOD

    DEFF Research Database (Denmark)

    Nørlund Christensen, A.; Hansen, P.; Lehmann, M. S.

    1976-01-01

    Samples of orthorhombic chromium oxide hydroxide, beta -CrOOH, and the deuterated compound, beta -CrOOD, were prepared hydrothermally. The crystal structures were determined by powder profile refinement technique using neutron diffraction data. Unit cells are: beta -CrOOH: a equals 4. 862(2) A, b...

  8. An imidazoline compound completely counteracts interleukin-1[beta] toxic effects to rat pancreatic islet [beta] cells

    DEFF Research Database (Denmark)

    Papaccio, Gianpaolo; Nicoletti, Ferdinando; Pisanti, Francesco A

    2002-01-01

    In vitro studies have demonstrated that interleukin (IL)-1beta decreases insulin and DNA contents in pancreatic islet beta cells, causing structural damage, that it is toxic to cultured human islet beta cells and that it is able to induce apoptosis in these cells....

  9. Lymphocyte beta 2-adrenoceptors mirror precisely beta 2-adrenoceptor, but poorly beta 1-adrenoceptor changes in the human heart

    NARCIS (Netherlands)

    Michel, M. C.; Beckeringh, J. J.; Ikezono, K.; Kretsch, R.; Brodde, O. E.

    1986-01-01

    To study the relationship of changes in human lymphocyte beta-adrenoceptors to changes potentially occurring in solid tissues we studied 16 patients undergoing elective coronary artery bypass grafting and determined the density of lymphocyte beta 2-adrenoceptors [by (-)125I-iodocyanopindolol (ICYP)

  10. Application of gamma radiation on disinfestation feed grain based food for domestic animals; Aplicacao da radiacao gama na desinfestacao de racoes a base de graos para alimentacao de animais domesticos

    Energy Technology Data Exchange (ETDEWEB)

    Ramos, Amanda Cristina Oliveira

    2009-07-01

    This study aimed to realize a survey to identify the associated insects to feed the city Sao Paulo / SP and also to assess the effect of gamma radiation on food ration for domestic animals infested by pests. Samples of 20 stores, 'Pet Shop' in different regions in Sao Paulo / SP were subjected to trials of 1 and 45 days for collection of insects with the aid of plastic tray and screens of different sizes. The species Sitophilus zeamais, Cryptolestes ferrugineus, Lasioderma serricorne and Oryzaephilus sp. showed a higher frequency. In assessing the effects of gamma radiation we used samples of maize, sunflower seeds and mix for rodents infested with adults of the species Sitophilus zeamais, Lasioderma serricorne and Plodia interpunctella, after the period of 7 to 10 days the insects were removed and samples subjected to increasing doses of gamma radiation. The species Sitophilus zeamais and Lasioderma serricorne subjected doses from 0,25 to 1,50 kGy and species Plodia interpunctella doses from 0,10 to 2,0 kGy. After 40 days of irradiation was evaluated the number of insects emerged. The results of bioassays with Sitophilus zeamais and with Lasioderma serricorne demonstrated that doses starting at 0,5 kGy was sufficient to cause mortality of eggs and newly emerged larvae. The results with Plodia interpunctella from the 1,5 kGy, hasn't emerged adult insects, concluding that these doses were sufficient to cause mortality of eggs and larvae. (author)

  11. Development of TiBr semiconductor crystal for applications as radiation detector and photodetector; Desenvolvimento do cristal semicondutor de brometo de talio para aplicacoes como detector de radiacao e fotodetector

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Icimone Braga de

    2006-07-01

    In this work, Tlbr crystals were grown by the Bridgman method from zone melted materials. The influence of the purification efficiency and the crystalline surface quality on the crystal were studied, evaluating its performance as a radiation detector. Due to significant improvement in the purification and crystals growth, good results have been obtained for the developed detectors. The spectrometric performance of the Tlbr detector was evaluated by {sup 241}Am (59 keV), {sup 133}Ba (80 e 355 keV), {sup 57}Co (122 keV), {sup 22}Na (511 keV) and {sup 137} Cs (662 keV) at room temperature. The best energy resolution results were obtained from purer detectors. Energy resolutions of 10 keV (16%), 12 keV (15%), 12 keV (10%), 28 keV (8%), 31 keV (6%) and 36 keV (5%) to 59, 80, 122, 355, 511 and 662 keV energies, respectively, were obtained. A study on the detection response at -20 deg C was also carried out, as well as the detector stability in function of the time. No significant difference was observed in the energy resolution between measurements at both temperatures. It was observed that the detector instability causes degradation of the spectroscopic characteristics during measurements at room temperature and the instability varies for each detector. This behavior was also verified by other authors. The viability to use the developed Tlbr crystal as a photodetector coupled to scintillators crystals was also studied in this work. Due to its quantum efficiency in the region from 350 to 500 nm, Tlbr shows to be a promising material to be used as a photodetector. As a possible application of this work, the development of a surgical probe has been initiated using the developed Tlbr crystal as the radiation detector of the probe. (author)

  12. Ionizing radiation dose control for workers in a nuclear plant working with unsealed sources; Controle da dose de radiacao ionizante para trabalhadores em uma instalacao radiativa com fontes nao seladas

    Energy Technology Data Exchange (ETDEWEB)

    Gerulis, Eduardo

    2006-07-01

    With the liberation of the use of the nuclear energy for peaceful applications, International Commission Radiological Protection, ICRP, founded in 1928, created a system of protection of the undesirable doses of ionizing radiation in 1958. This has been received by workers, members of the public and environment and hence it became possible for the introduction of these applications. This protection system is adopted by the International Agency of Energy Atomic, IAEA, that publishes recommendations in safety series, 88 and by the Comissao Nacional de Energia Nuclear, CNEN, which publishes these regulations. The international recommendations and national regulations were adapted and they need to be applied in this way. The present paper uses recommendations of the publication 75 from ICRP, of the publication 115 from 88 and regulations of the regulation NN 3.01 from CNEN to present, through radiological protection measures, the ionizing radiation dose control for workers in a nuclear plant that works in the research, production, division and packing of unsealed sources to be used in clinical applications. In that way it is possible to prevent appropriately the undesirable doses and to confirm the received doses. (author)

  13. The benefits of prone SPECT myocardial perfusion imaging in reducing both artifact defects and patient radiation exposure; Beneficio da aquisicao de imagem na posicao Prona em perfusao miocardica com SPECT para reducao de artefatos e exposicao do paciente a radiacao

    Energy Technology Data Exchange (ETDEWEB)

    Stathaki, Maria; Koukouraki, Sophia; Papadaki, Emmanouela; Tsaroucha, Angeliki; Karkavitsas, Nikolaos, E-mail: mariast_cha@yahoo.gr [Department of Nuclear Medicine, University Hospital of Heraklion, Crete (Greece)

    2015-10-15

    Background: Prone imaging has been demonstrated to minimize diaphragmatic and breast tissue attenuation. Objectives: To determine the role of prone imaging on the reduction of unnecessary rest perfusion studies and coronary angiographies performed, thus decreasing investigation time and radiation exposure. Methods: We examined 139 patients, 120 with an inferior wall and 19 with an anterior wall perfusion defect that might represented attenuation artifact. Post-stress images were acquired in both the supine and prone position. Coronary angiography was used as the 'gold standard' for evaluating coronary artery patency. The study was terminated and rest imaging was obviated in the presence of complete improvement of the defect in the prone position. Quantitative interpretation was performed. Results were compared with clinical data and coronary angiographic findings. Results: Prone acquisition correctly revealed defect improvement in 89 patients (89/120) with inferior wall and 12 patients (12/19) with anterior wall attenuation artifact. Quantitative analysis demonstrated statistically significant difference in the mean summed stress scores (SSS) of supine and mean SSS of prone studies in patients with disappearing inferior wall defect in the prone position and patent right coronary artery (true negative results). The mean difference between SSS in supine and in prone position was higher with disappearing than with remaining defects. Conclusion: Technetium-99m (Tc-99m) tetrofosmin myocardial perfusion imaging with the patient in the prone position overcomes soft tissue attenuation; moreover it provides an inexpensive, accurate approach to limit the number of unnecessary rest perfusion studies and coronary angiographies performed. (author)

  14. Adequacy and adjustment of electromechanical elements of a X radiation generator for automation of system of additional filtration; Adequacao e ajuste dos elementos eletromecanicos de um gerador de radiacao X para automacao do sistema de filtracao adicional

    Energy Technology Data Exchange (ETDEWEB)

    Alves Junior, Iremar; Santos, Lucas dos; Potiens, Maria da Penha A.; Vivolo, Vitor, E-mail: iremarjr@usp.b, E-mail: lucas.se@usp.b, E-mail: mppalbu@ipen.b, E-mail: vivolo@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2011-10-26

    This paper dimensioned the filter wheel components and the adequacy of additional filtrations for the implantation of the OTW automated system with complete replacement of previous used filtration by new set of machine-made filters to be used as the qualities already implanted at the Instrument Calibration Laboratory of the IPEN, Sao Paulo, Brazil. In the sequence, it was performed the measurements of kerma i the air in each quality to be used as reference values

  15. Study of the behavior of radiation detectors for mammography in standard beams using a clinical system; Estudo do comportamento de detectores de radiacao para mamografia em feixes padroes utilizando um sistema clinico

    Energy Technology Data Exchange (ETDEWEB)

    Barreira, Jacqueline Sales

    2014-07-01

    A mammogram is the x-ray of the breast that allows early detection of cancer, by being able to show lesions in very small early stage. But to get an early and reliable diagnosis is necessary that the mammography unit is calibrated and working properly, otherwise there may be a loss in image produced, may lead to a false diagnosis, and possible harm to the patient. So it is important to control these devices, especially in relation to the radiation produced by them. In this project, we propose a study of the behavior of ionization chambers for mammography calibrated beam patterns in a clinical system (Philips-VMI mammography, Graph Mammo AF, which operates a range of 20 to 35 kV) from Instruments Calibration Laboratory at IPEN-CNEN/SP, with the aim of determining parameters correction approaching conditions calibration conditions for clinical use. Measurements of the parameters of the beams set in mammography using simulators acrylic specially developed for these measurements were performed in order to establish a new protocol for calibration of the ionization chambers in a clinical system rather than the industrial system, or as a complement to this. (author)

  16. Evaluation of area monitor response for neutrons in radiation field generated by a 15 MV clinic accelerator; Avaliacao da resposta dos monitores de area para neutrons em campo de radiacao gerado por um acelerador clinico de 15 MV

    Energy Technology Data Exchange (ETDEWEB)

    Salgado, Ana Paula

    2011-07-01

    The clinical importance and usage of linear accelerators in cancer treatment increased significantly in the last years. Coupled with this growth came the concern about the use of accelerators with energies over to 10 MeV which produce therapeutic beam contaminated with neutrons generated when high-energy photons interact with high-atomic-number materials such as tungsten and lead present in the accelerator itself. At these facilities, measurements of the ambient dose equivalent for neutrons present difficulties owing to the existence of a mixed radiation field and possible electromagnetic interference near the accelerator. The Neutron Laboratory of the IRD - Brazilian Institute for Radioprotection and Dosimetry, aiming to evaluate the survey meters performance at these facilities, initiated studies of instrumentation response in the presence of different neutron spectra. Neutrons sources with average energies ranging from 0.55 to 4.2 MeV, four different survey meters and one ionization chamber to obtain the ratio between the dose due to neutrons and gamma radiation were used in this work. The evaluation of these measurements, performed in a 15 MV linear accelerator room is presented. This work presents results that demonstrate the complexity and care needed to make neutrons measurements in radiotherapy treatment rooms containing high energy clinical accelerators. (author)

  17. Dose rate range extension of the calibration of dosemeters at LNMRI, Rio de Janeiro, Brazil; Expansao da faixa de taxas de dose para a calibracao de instrumentos de medir radiacao no LNMRI, Rio de Janeiro, Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Cabral, T.S.; Carlos, M.T.; Ramos, M.M.O., E-mail: tschirn@ird.gov.b, E-mail: marcia@ird.gov.b, E-mail: mmoramos@ird.gov.b [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2009-07-01

    The present work has an objective the implantation of a experimental arrange for application of essays of instrument calibration for measurement of low dose rate, which measure rate less than 10 {mu}Sv/h

  18. Fabrication and electrical characterization of polyaniline-silicon heterojunction for gamma radiation dosimetry application; Fabricacao e caracterizacao eletrica de heterojuncoes de polianilina - silicio para aplicacao em dosimetria de radiacao gama

    Energy Technology Data Exchange (ETDEWEB)

    Laranjeira, Jane Maria Goncalves

    2004-08-15

    In this work a technique has been developed to fabricate high quality polyaniline-silicon heterojunction diodes for use as gas and/or ionizing radiation sensors. Polyaniline thin films (40 nm thick) produced by spin-coating on silicon substrates, were the active part of the junction structure. The devices presented excellent reproducibility of their electrical characteristics with high rectification ratio, 60,000 at {+-}1.0 V, and typical reverse current at - 1.0 V of 3 nA at 295 K. A G/I x G plot has been used to analyze the current-voltage characteristics, yielding typical series resistance of 4 k{omega} {+-} 5% and ideality factor in a range of 1,9 {+-} 0.5%. The heterojunction diode presents high sensitivity to gamma radiation in the dose range of 3 x 10{sup -2} to 7 kGy with a linear response in the forward and reverse bias. The excellent electrical characteristics together with the linear response with the dose, strongly suggest the application of this device for spectrometry or dosimetry of high doses of gamma radiation. These devices presented high sensitivity to gas moistures such as ammonia, nitric acid and trichloroethylene. In both cases the sensitivity was observed through shifts of the current-voltage curves, which can be easily monitored to provide a calibration curve of the sensor either as a radiation dosimeter or as a gas sensor for use in applications for gas monitoring or radiation dosimetry. Several aspects of the reliability physics of silicon-polyaniline heterojunction, such as degradation effects induced by local heating, charge trapping and temperature changes, have been discussed. These results further confirm the quality of the devices electrical characteristics and their suitability for radiation and gas sensors applications. Another interesting results presented in this work was the use of polyemeraldine nanofilms (thickness in the range 30-50 nm) deposited by 'spin coating' on glass substrates as an optical dosimeter for gamma radiation based on the color change of the polymer. The nanofilms devices were characterized by UV visible absorption spectroscopy. The deep blue color, characteristic of undoped polyaniline films before irradiation, becomes subsequently green as the film is being irradiated, and the film absorption coefficient exhibits a linear dependence with the logarithm of the irradiation dose from I to 10 kGy. (author)

  19. Study on the application of gamma radiation for the utilization of the polytetrafluoroethylene (PTFE) scraps polymerized by emulsion; Estudo da aplicacao da radiacao gama para o aproveitamento de aparas de politetrafluoroetileno (PTFE) polimerizado por emulsao

    Energy Technology Data Exchange (ETDEWEB)

    Rosner, Gerhardyne O.; Ikari, Carolina T.; Oliveira, Ana C.F. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Centro de Quimica e Meio Ambiente (CQMA); Faculdades Oswaldo Cruz, Sao Paulo, SP (Brazil); Ferreto, Helio F.R.; Lima, Luiz F.C.P.; Lugao, Ademar B., E-mail: hferreto@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Centro de Quimica e Meio Ambiente (CQMA); Moreira, Otavio M. [Faculdades Oswaldo Cruz, Sao Paulo, SP (Brazil)

    2009-07-01

    This paper presents an option for the re utilization of the PTFE scraps which can be the copolymerization by grafting, in which a monomer (ethylene, 1.3-butadiene, acetylene or styrene) is added to its polymer chain. The choose technique for obtaining the grafting was the gamma radiation. The PTFE is submitted to gamma radiation doses for obtaining free radicals which the grafting will be possible. Two gamma radiation grafting methods were compared: the direct method which consists the sample irradiation in presence of monomer, and the indirect method, in which the samples are irradiated under inert atmosphere, or air, and it is added the monomer, gas or liquid. In this method samples were sent under inert atmosphere (N{sub 2}). For the PTFE-g-monomer copolymer characterization, the following techniques were used: infrared absorption spectroscopy, thermogravimetric analyses, and derivative and mass grafting percentage

  20. Preparation of PtRu/C anode electrocatalysts using gamma radiation for methanol electro-oxidation; Preparacao de eletrocatalisadores PtRu/C utilizando radiacao gama para aplicacao como anodo na oxidacao direta de metanol

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Dionisio Fortunato da

    2006-07-01

    Pt Ru/C (carbon-supported Pt Ru nanoparticles) anode electrocatalysts were prepared using radiolytic process (gamma radiation) and tested for methanol electro-oxidation. In this process, water/2-propanol and water/ethylene glycol solutions containing the metallic ions and the carbon support were submitted to gamma radiation under stirring. The water/alcohol ratio (v/v) and the total dose (kGy) were studied. A nominal Pt Ru atomic ratio of 50:50 were used in all experiments. The electrocatalysts were characterized by energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD), transmission electron microscopy (TEM) and cyclic voltammetry (CV). The electro-oxidation of methanol was studied by cyclic voltammetry using the thin porous coating technique. The electrocatalysts prepared in water/2-propanol showed crystallite size in the range of 3-5 nm and Pt Ru atomic ratio of 50:50. The electrocatalysts prepared in water/ethylene glycol showed crystallite size (2-3 nm) smaller than the ones obtained in water/2-propanol, however, the Pt Ru atomic ratios obtained were approximately 80:20, showing that only part of ruthenium ions were reduced. For methanol oxidation the electrocatalytic activity depends on the water/2-propanol and water/ethylene glycol ratio used in the reaction medium. The electrocatalysts prepared in water/2-propanol showed inferior performance to the ones prepared in water/ethylene glycol, which showed similar or superior performances (amperes per gram of platinum) to the commercial electrocatalyst from E-TEK. (author)

  1. Acceptance criteria for deposition of low-level and intermediate-level radiation levels radioactive wastes; Criterios de aceitacao para deposicao de rejeitos radioativos de baixo e medio niveis de radiacao

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-09-15

    This norm establishes the criteria for acceptance low and intermediate radiation level for safe deposition in repositories, for assuring the protection of workers, population and environment against the hazardous effects of the ionizing radiations. The criteria of this norm applies to the low and intermediate radiation levels.

  2. Project, construction and characterization of ionization chambers for use as standard systems in X and gamma radiation beams; Projeto, construcao e caracterizacao de camaras de ionizacao para utilizacao como sistemas padroes em feixes de radiacao X e gama

    Energy Technology Data Exchange (ETDEWEB)

    Perini, Ana Paula

    2013-07-01

    Ionization chambers present some advantages in relation to other dosimeters: easiness of handling, low energy dependence and high precision. The advantages associated to ionization chambers and the large number of diagnostic radiology exams and therapeutic treatments motivated the development of this PhD program. In this project ionization chambers were developed and characterized to be applied in diagnostic radiology and therapy beam dosimetry, with high precision and performance, in compliance with international recommendations. They were assembled in a simple way, utilizing low-cost national materials, so they can be reproduced and applied at calibration laboratories. The project of these ionization chambers presents some differences in relation to commercial ionization chambers, as the materials utilized and geometrical arrangements. Besides the development of the ionization chambers to be utilized in standard X-ray beam dosimetry as work standard systems, two graphite parallel-plate ionization chambers were developed and characterized to be applied as reference standard systems for determining the air kerma rates of gamma radiation sources. Comparing the air kerma rates determined with the reference standard of the Calibration Laboratory of IPEN, a Farmer ionization chamber, with the values of the air kerma rates obtained with the graphite ionization chambers, the maximum differences obtained were only 1.7% and 1.2% for the G1 and G2 graphite ionization chambers, respectively. Moreover, these ionization chambers presented correction factors close to 1.000, which is ideal for an ionization chamber be characterized as a reference standard system. (author)

  3. Implantation of radiation qualities for mammography in accordance with the IEC 61627 and TRS 457 criteria; Implantacao das qualidades de radiacao para mamografia, segundo os criterios da IEC 61627 e do TRS 457

    Energy Technology Data Exchange (ETDEWEB)

    Pires, Evandro J.; David, Mariano G.; Almeida, Carlos Eduardo de, E-mail: pires@lcr.uerj.b [Universidade do Estado do Rio de Janeiro (LCR/UERJ), RJ (Brazil). Lab de Ciencias Radiologicas; Peixoto, J. Guilherme, E-mail: guilhem@ird.gov.b [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2009-07-01

    In this work it is discussed the technical conditions of the implantation of radiation qualities adequate for dosemeter applied to mammography at the Radiological Science Laboratory (RSL) of the University of State of Rio de Janeiro, Brazil. It performed tests for evaluation the homogeneity of the radiation field, the scattering, the half-layers and the system stability. The test results point for adequacy of the laboratory installed at the LCR for calibration of the mentioned dosemeters in seven qualities of radiation and the expanded uncertainty with better capacity of measurement at those qualities was of {+-}1.8% (k = 2)

  4. Assessment of ionizing radiation as a risk factor for breast cancer incidence in Goiania; Avaliacao da radiacao ionizante como fator de risco para a incidencia de cancer de mama em Goiania

    Energy Technology Data Exchange (ETDEWEB)

    Lage, Leonardo Bastos

    2016-11-01

    This research aims to evaluate whether exposure to ionizing radiation to which women are subjected can be associated with the incidence of breast cancer in Goiania. The defined study area is the central region of Goiania, or the Sanitary Districts of Campinas-Centro and Sul, in which are the seven major accident sources of contamination with Cesium 137, and also, as shown by previous study, the majority of new cases of breast cancer (60,43 %). We used the geographical division of the city in census tracts and health districts. The data collection was divided in two stages: the first, for the survey of radiometric measurements, and the second, for identifying the addresses of women diagnosed with breast cancer. The radiometric survey occurred between 2010 and 2014, in which was used an environmental gamma radiation mobile measuring system. This system was composed by a high-sensitivity detector coupled to a Global Positioning System (GPS) and a microcomputer. The assembly was installed on a motor vehicle so that the height of the detector is found at one meter from the ground, and programmed to obtain a measurement of the doses absorbed in the air rate each second. The data collected were: doses absorbed in the air rate, geographical coordinates, altitude, date and time of acquisition. From Mobisys software, files were generated and from ArcGIS 10.0 platform, geospatial assessment survey through the elaboration of thematic maps and geospatial analysis statistics. The annual averages of effective doses and collective effective doses were estimated from the rate of doses absorbed in air collected by the system and the resident population in the census tracts. The second stage begun from the data collection at the Registry of Goiania's Population Based Cancer (RCBPGO), in which were identified addresses of women diagnosed with breast cancer between 2001 and 2010. Part of the data was geographically referenced and using census data were estimated and compared the annual averages of crude rates of incidence. The spatial correlation of groups (clusters) of new cases has been verified, through the Moran index, and from geographically referenced radiometric measurements obtained in the previous step, the correlation between the incidence of breast cancer and ionizing radiation levels was assessed by unconditional linear regression. The results were presented in two papers. In the first, radiometric surveys were conducted in 1.405 of the 1.636 (85,9%) census tracts sectors that make up the seven Sanitary Districts in the city of Goiania. In total 197.811 geographically referenced measures of the absorbed dose rate in the air were made, with a average of 29,85 ± 7,47 and amplitude from 9,17 to 629,88 nGy/h. From these values were estimated the average of annual effective dose and collective effective dose for outdoor environments, with values of 0,036 ± 0,003 mSv/year and 28,51 ± 11,68 man.mSv/year, respectively. The levels of exposure to external gamma radiation, found in the city of Goiania 28 years after the radiological accident with Cesium-137, are compatible with the values estimated by UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation). And the value of the annual average of effective dose in Goiania, is lower than in other places in Brazil, which have only 'background' of natural radiation outdoors. The results obtained in this study indicate that the dosimetric situation in Goiania does not present undue risk to people and the environment. In the second article, were identified 4.105 new cases of breast cancer, 2.233 in the study area and 1.286 (57,59%) of these geographically referenced. The annual average values of crude rates of incidence, considering the total numbers of cases and geographically referenced presented in the study area are, respectively, 102,91 and 71,86 new cases per 100.000 women. The crude rate of incidence in Goiania was 66,59 cases per 100.000, while in the study area was 102,91 cases per 100.000 and, outside the area, 46,86 ca ses per 100.000. These value s are within the range of average values presented by other Brazilian capitals, which is 130,99 cases per 100.000 in Porto Alegre-RS, and 20,04 cases in Macapa/AP, and the national average in the capital of 79,37 cases per 100.000 women. The cluster analysis showed a slight spatial correlation of crude rates of breast cancer incidence in three small sets of census tracts, far from the accident sources of contamination with Cesium-137. The scatter plot points and the R{sup 2} value did not indicate any association between the crude rates of incidence and radiometric measurements. This study supports the hypothesis that ionizing radiation levels to which women living in Goiania are exposed, are not associated with the emergence of new cases of breast cancer. (author)

  5. Fusion of protoplasts with irradiated micro protoplasts as a tool for radiation hybrid panel in citrus;Fusao de protoplastos com microprotoplastos irradiados como ferramenta para painel hibrido de radiacao em citros

    Energy Technology Data Exchange (ETDEWEB)

    Bona, Claudine Maria de, E-mail: debona@iapar.b [Instituto Agronomico do Parana (IAPAR), Curitiba, PR (Brazil). Centro Administrativo do Governo do Estado; Stelly, David, E-mail: stelly@tamu.ed [Texas A and M University (Tamu), College Station, TX (United States). Dept. of Soil and Crop Sciences; Miller Junior, J. Creighton, E-mail: jcmillerjr@tamu.ed [Texas A and M University (Tamu), College Station, TX (United States). Dept. of Horticultural Sciences; Louzada, Eliezer Silva, E-mail: elouzada@ag.tamu.ed [Texas A and M University, (Tamuk), Weslaco, TX (United States)

    2009-12-15

    The objective of this work was to combine asymmetric somatic hybridization (donor-recipient fusion or gamma fusion) to microprotoplast-mediated chromosome transfer, as a tool to be used for chromosome mapping in Citrus. Swinglea glutinosa micro protoplasts were irradiated either with 50, 70, 100 or 200 gamma rays and fused to cv. Ruby Red grapefruit or Murcott tangor protoplasts. Cell colonies were successfully formed and AFLP analyses confirmed presence of S. glutinosa in both 'Murcott' tangor and 'Ruby Red' grapefruit genomes. (author)

  6. A methodology to establish the appearance of cancer cases due to radiation dose in compressed breast; Uma metodologia para comprovar o aparecimento de casos de cancer devido a dose de radiacao na mama comprimida

    Energy Technology Data Exchange (ETDEWEB)

    Feital, Joao Carlos Da Silva; Delgado, Jose Ubiratan; Peixoto, Jose Guilherme P.; Fonseca, Hugo Geraldo Da, E-mail: jfeital@ird.gov.br, E-mail: delgado@ird.gov.br, E-mail: guilherm@ird.gov.br, E-mail: hfonseca@ird.gov.br [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2013-10-01

    It is known that more than 20% of the world's population will contract some type of cancer. In Brazil, with the exception of skin cancer (non melanoma) the breast cancer ranks first among the higher frequency of tumours among women and in general, although the methods of detection are advancing in the year 2010 took place about 13 thousand deaths in about 50,000 cases, probably due to late detection of these neoplasm. New cases of breast cancer in a given population can be proven from absorbed dose quantity, calculated for the compressed breast, due to the risk by means of exposure to x rays in this radiodiagnostic practices. Methodology: Exposures were held in an ionization chamber and the other quantities required were obtained to the screen-film equipment of mammography. Results: Also experimental results were of compressed breast an equivalent dose of ( 1.82 mSv {+-} 0.2%) or (3.64 mSv {+-} 0.2%) for both projections, i.e. medium lateral oblique and cranio caudal. The experimental value obtained here is consistent with the calculated results and published in the literature for analog and CR equipment. Conclusion: From the result of dose equivalent in the breast, one can say that there will be effectively attesting as to the appearance of new cases of cancer if approximately 80 million women are exposed to radiation emitted by mammographers. (author)

  7. Gamma radiation applied to extend the shelf-life of lamb meat vacuum packed and stored under refrigeration; Radiacao gama aplicada para estender a vida util da carne de cordeiro embalada a vacuo e armazenada sob refrigeracao

    Energy Technology Data Exchange (ETDEWEB)

    Fregonesi, Raul Pereira

    2013-07-01

    The State of Sao Paulo has experienced in recent years a significant increase in production, supply and consumption of lamb meat. With the current trend of demand for products of greater convenience, with speed and ease preparation, there is the need to invest in the market supply of refrigerated lamb cuts. Accordingly, irradiation with ionizing energy could be a viable alternative for the marketing of refrigerated cuts of lamb meat. The aim of this work was to study the application of different doses of gamma radiation in order to extend the stability of lamb meat vacuum packed and stored under refrigeration. For this, first a preliminary experiment was conducted aiming to determine parameters such as irradiation dose and storage time. The lamb loins (Longissimus dorsi) were vacuum packed, irradiated with doses of 1,0, 3,0 and 5,0 kGy and stored under refrigeration in cooling chamber at 1 °C. According to the results, a dose of 3,0 kGy may be indicated as the maximum dose of irradiation. After establishing these parameters, the final experiment began, and for that, the lamb loin samples were vacuum packaged and irradiated with doses zero (control), 1,5 kGy and 3,0 kGy and stored under refrigeration at 1 °C. In predetermined periods (zero, 14, 28, 42 and 56 days) microbiological and physical chemical analysis were carried out. Also, a sensory acceptance test was conducted, with 63 consumers, which evaluated aroma, texture, juiciness, flavor and overall quality attributes. All data were statistically evaluated using contrasts between means, with a significance level of 5%. The results obtained for microbiological testing of all samples were absence of Salmonella sp. and sporadic counts of coliforms at 45 °C and Staphylococcus aureus (<10 (est) CFU/g). For other microbiological analysis there were significant effects (p <0,05) of treatment, and time. However, for the physicochemical characteristics, there were only differences (p <0,05) of time from zero to 28 days for pH and color b * (yellow), which declined and increased, respectively, over this period. In the sensory acceptance test, the samples did not differ (p> 0,05) in any of the evaluated attributes. Thus, it was concluded that gamma irradiation in the lamb loins was effective in decreasing the proliferation of microorganisms without damaging its physical and chemical characteristics. At the end of the experiment, it was possible to say that the 3.0 kGy dose was indicated because could extend the shelf life of 14 to 56 days of loin of lamb irradiated and stored at 1 °C . (author)

  8. Radiation beans characterization and implantation for study of lead equivalent individual protection device used in radiodiagnostic practices; Caracterizacao e implantacao de feixes de radiacao para estudo de dispositivos de protecao individual com equivalencia em chumbo utilizados em praticas de radiodiagnostico

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Leslie Silva

    2004-07-01

    The protective shielding (IPC) must be used by occupationally exposed professionals, patients and volunteers, in order to optimize the doses who receive due to radiological practices. International and national norms establish the methodology to be adopted for determination of the IPC attenuation. In this work, the IPC had been submitted to X-rays beams with known characteristics, standardized for determination of their attenuation equivalent thickness by comparison to an experimental lead attenuation slope. This comparison technique allowed insurance estimative of the IPC attenuation equivalent thickness in mm of lead. Thus, it was possible to verify the conformity of the attenuation equivalent thickness determined experimentally and the value of the thickness indicated by the manufacturer. To carry out this work, it was necessary the implementation of experimental setups stated in the specifics norms, the study of the X-rays beams original features and the determination of combined additional filters, in order to allow the X-ray equipment used operates in compliance with Norm IEC 61331-1 IEC. The radiation quality selected is characterized by a 100 kV voltage and a 0.25 mm of copper overall filtration. The implementation of this radiation quality it was carried through of its first and second HVL (Half Value Layer). Thus, a methodology according to the international Norms has been implemented in the laboratory. The results of the present work provide suitable and useful information about radiation beams features related to the determination techniques of the attenuation properties. Once implemented the procedures for conformity evaluation of the protection devices, it will be possible to carry out specific quality control tests, which will be helpful to manufacturers, customers, as well as authorities in the radiological protection and health areas. (author)

  9. Quantification of micronuclei in blood lymphocytes of patients exposed to gamma radiation for dose absorbed assessment; Quantificacao de micronucleos em linfocitos de pacientes expostas a radiacao gama para a avaliacao da dose absorvida

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa, Isvania Maria Serafim da Silva

    2003-02-15

    Dose assessment in an important step to evaluate biological effects as a result of individual exposure to ionizing radiation. The use of cytogenetic dosimetry based on the quantification of micronuclei in lymphocytes is very important to complement physical dosimetry, since the measurement of absorbed dose cannot be always performed. In this research, the quantification of micronuclei was carried out in order to evaluate absorbed dose as a result of radiotherapy with {sup 60}Co, using peripheral blood samples from 5 patients with cervical uterine cancer. For this purpose, an aliquot of whole blood from the individual patients was added in culture medium RPMI 1640 supplemented with fetal calf serum and phytohaemagglutinin. The culture was incubated for 44 hours. Henceforth, cytochalasin B was added to block the dividing lymphocytes in cytokinesis. The culture was returned to the incubator for further of 28 hours. Thus, cells were harvested, processed and analyzed. Values obtained considering micronuclei frequency after pelvis irradiation with absorption of 0,08 Gy and 1,8 Gy were, respectively, 0,0021 and 0,052. These results are in agreement with some recent researches that provided some standard values related to micronuclei frequency induced by gamma radiation exposure in different exposed areas for the human body. The results presented in this report emphasizes biological dosimetry as an important tool for dose assessment of either total or partial-body exposure to ionizing radiation, mainly in retrospective dose investigation. (author)

  10. Toxicity assays applied for evaluation of ionizing radiation and zeolites adsorption as treatment technologies for coloured effluent; Aplicacao de ensaios de toxicidade na avaliacao da eficiencia da radiacao ionizante e da adsorcao em zeolitas para o tratamento de efluentes coloridos

    Energy Technology Data Exchange (ETDEWEB)

    Higa, Marcela Cantelli

    2008-07-01

    Textile industry is one raising commercial activity in Brazil. This activity has been generating important environmental interferences such as colour and bad biological effects into aquatic environment. Liquid textile effluents are toxic to lived organisms and may present low biological degradability. Although foreseen at federal regulation, the effluent quality is not controlled by toxicity assays in the country. These assays are carried out to determine the potential effects of chemical substances and effluents to cause negative effects to the exposed organisms. The present work aimed whole toxicity evaluation as well as the applicability of two different treatment techniques: ionizing radiation and zeolite adsorption. The efficacy of them were evaluated using eco toxicity bases and real effluents. Two different industries from Sao Paulo State contributed to this project supplying their real effluents. The samples were collected at a Textile Industry and at a Chemical Industry (dying producer) and after the measurement of whole toxicity the samples were submitted to treatments. Toxicity assays were carried out for Daphnia similis and for Vibrio fischeri. Sample irradiations were performed at an Electron Beam Accelerator at CTR/IPEN. Zeolites treatment is an P and D activity from CQMA/IPEN which contributed to this Project. Zeolites v/ere prepared from fly ash previously being used as an adsorber material. Both treatments (electron irradiation and zeolite adsorption) resulted on important toxicity and colour reduction. Concerning irradiation the effluents from chemical industry required higher radiation doses than that from textile activity. The radiation dose to be suggested is 40 kGy (toxicity reduction > 60%) for the chemical effluents and 0.5 kGy for the textile effluents (toxicity reduction > 90%). When zeolite adsorption was evaluated the Z1M6 resulted in 85%o v/hole toxicity reduction and ZC6 resulted in very low efficiency for the effluents of chemical industry. (author)

  11. Chemical modification of high molecular weight polyethylene through gamma radiation for biomaterials applications; Modificacao quimica de polietileno de alto peso molecular atraves de radiacao gama para aplicacao em biomateriais

    Energy Technology Data Exchange (ETDEWEB)

    Raposo, Matheus P.; Rocha, Marisa C.G., E-mail: matheusmerlim@hotmail.com [Universidade Estado do Rio de Janeiro (UERJ), Nova Friburgo, RJ (Brazil). Instituto Politecnico

    2015-07-01

    Ultra high molecular weight polyethylene has been used in the medical field due to its high mechanical properties compared to the other polymers. Its main application is in the development of orthopedic implants, which requires high resistance to abrasion. One of the most used methods is the introduction of crosslinks in the polymer through gamma irradiation. In order to prevent oxidation reactions, studies have been developed using tacoferol (vitamin E) as an antioxidant for the material. The ascorbic acid (vitamin C), however, has been appointed as a viable alternative for vitamin E. In this work, a high molecular weight polyethylene grade (HMWPE) and polyethylene samples formulated with vitamin C were submitted to gamma radiation. Thermodynamic-mechanical methods and gel content determinations were used to characterize the samples obtained. The sample containing 1% of vitamin C and irradiated with 50 KGy of gamma radiation presented the highest content of crosslinks. (author)

  12. Application of gamma irradiation for incorporation of rubber powder in the formulations of EPDM and natural rubber; Aplicacao da radiacao gama para incorporacao do po de borracha em formulacoes de borracha natural e EPDM

    Energy Technology Data Exchange (ETDEWEB)

    Kiyan, Ludmila Y.P.; Parra, Duclerc Fernandes; Lugao, Ademar Benevolo, E-mail: ludmilapozzo@gmail.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP/CQMA), Sao Paulo, SP (Brazil). Centro de Quimica e Meio Ambiente

    2013-07-01

    The objective of this work was to study the behavior of the recycling of rubber burrs in form of powder, of the rubber industry from EPDM rubber powder and natural rubber with SBR. The rubber powder was irradiated and reused in rubber artifacts formulations for classical vulcanization. The processed material was irradiated using a {sup 60}Co source in doses of 50, 100, 150 and 200 kGy and a dose rate of 5 kGy s-1 at room temperature. The radiation created devulcanization active sites for subsequent integration of the material (rubber powder) in formulations of commercial use. The processes were compared and their products characterized by analytical methods of the physical properties such as strength and elongation. Satisfactory results were found, noting a major spin-off of EPDM chain demonstrated by increased elongation.

  13. Polymer matrices obtained by ionizing radiation for using in controlled drug delivery systems; Matrizes polimericas obtidas mediante radiacao ionizante para sua utilizacao como sistemas de liberacao controlada de farmacos

    Energy Technology Data Exchange (ETDEWEB)

    Martellini, Flavia

    1998-07-01

    Two kinds of controlled drug delivery system were obtained by gamma radiation induced polymerization. One of the system was obtained from an acrylic derivative of acetaminophen (40-hydroxyacetanilide), by copolymerization of 4-(acryloyloxy) acetanilide and N,N-dimethylacrylamide (DMAA) in dimethylformamide solution with 0,16 kGy/h dose rate and 54 Gy dose. The values of reactivity rate, r-D{sub MAA} = 0,31 {+-} 0,02 e r{sub AOA} -0,07 {+-} 0,12, were determined by Fineman-Ross method. The acetaminophen hydrolysis was carried out in alkaline and enzymatic (trypsin) media. Another kind of drug delivery system studied was solvent controlled type, being the drug immobilized in the hydrogel,. The hydrogels prepared by radiation polymerization of acryloyl-L-propine methylester (A-Pro-OMe) with 10 Gy dose, showed thermosensible property, swelling or shrinking in water with decreased or increased temperatures. The hydrogels were obtained with different crosslink density, trimethylolpropane trimethacrylate, and the monomers N, N-dimethyl acrylamide (DMAA) and 2-cyanoethyl acrylate to study the influence of the composition in the drug delivery rate. It was verified that the porous size besides being a characteristic of the matrix composition, it was also temperature dependent (thermosensible). The analgesic drug acetaminophen was immobilized by entrapment and by physical adsorption into the hydrogels matrices for 'in vitro' study. The insulin was immobilized by adsorption for 'in vivo' study. (author)

  14. Application gamma radiation of cobalt-60 in disinfestation of some types of rations for feeding small animals; Emprego da radiacao gama do cobalto-60 na desinfestacao de alguns tipos de racoes para alimentacao de animais de pequeno porte

    Energy Technology Data Exchange (ETDEWEB)

    Arthur, Paula Bergamin

    2012-07-01

    The pests as beetles, mites, moths and mushrooms among other, usually infest products stored as: grains, crumbs, flours, coffee, tobacco, dried fruits, animal rations, spices, dehydrated plants, causing the visual depreciation and promoting to deterioration of the products. The present research had as objective the use of the gamma radiation in the disinfestation of some types of rations used for feeding animals of small size. In the first experiment packing of free samples were used measuring 10 cm x 20 cm with capacity of 70 grams of substrate (ration) with 4 types of existent marks in the trade: (1), (2), e (3), and (4). Each treatment consisted of 10 repetitions, that were irradiated with doses of: 0 (control) 0,5; 1,0 and 2,0 kGy, to do the disinfestation of the samples. After the irradiation (disinfestation) of the all irradiated packing and more the control was conditioned in plastic boxes of 80 cm x 50 cm with cover, where the insects were liberated Lasioderma serricorne, Plodia interpuctella, Sitophilus zeamais and Sitophilus oryzae, in a total of 400 for each box and maintained at room acclimatized with 27 {+-} 2 Deg C and relative humidity of 70 {+-} 5%. In the second experiment packing were used made with the materials of packing of the first experiment. Each packing was made of 10 cm x 15 cm, with capacity of 30 grams of substrate (ration). In each repetition was inoculated 10 insects of each species, in a total of 400 insects for experiment per box. The packing with substrate and insect, were stamped in commercial machine and irradiated with doses of: 0 (control) 0,5; 1,0 and 2,0 kGy. The irradiated packing and the control were maintained at room acclimatized same the mentioned in the first experiment. The counting of the number of insects and holes in the packing were made after 60 days. Concluded that only the packing of the ration type number 4 was susceptive to attack of all species of insects. The dose of 0,5 kGy was sufficient to induce the sterilization and consequently the disinfestation of all studied rations. (author)

  15. Measures and modelling of PAR (photosynthetically-active radiation) for the Northeast of Brazil; Medidas e modelagem da radiacao PAR (photosynthetically-active radiation) para o nordeste do Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Tiba, Chigueru; Leal, Sergio da S.A. [Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Dept. de Energia Nuclear], e-mail: tiba@rce.neoline.com.br

    2004-07-01

    Photosynthetically active solar radiation, known by its acronym in the English language as PAR, is the principal driving force of innumerable biological and physical processes related to biomass production, such as, the evolution of vegetal covering, agricultural productivity, and countless environment aspects, among others. Unfortunately in Brazil and particularly in the Northeast of Brazil, the PAR radiation measures are not a routine part of meteorological station measures, and therefore are still rarer than solar irradiation measures. In this context, a station was installed in Recife, Pernambuco in 2003, to carry out simultaneous measures of daily solar irradiation and PAR irradiation, which permits the modelling and valuation of the relationship between these two parameters and thus makes the estimation of PAR radiation possible, where there used to be only information on solar irradiation. Three others stations are being installed, one on Fernando de Noronha-PE, another in Pesqueira-PE, and the other in Xingo-SE, which complete a group of 4 between Latitudes 8 deg and 10 deg South and Longitudes 34 deg to 38 deg West, each having differentiated Equatorial Climates: island maritime, continental maritime, sylvan (Agreste) and semi-arid. (author)

  16. Purification and preparation of bismuth(III) iodide for application as radiation semiconductor detector; Purificacao e preparacao do cristal semicondutor de iodeto de bismuto para aplicacao como detector de radiacao

    Energy Technology Data Exchange (ETDEWEB)

    Ferraz, Caue de Mello

    2016-11-01

    This study describes the experimental procedure of a BiI{sub 3} purification method powder, aiming a future application of these semiconductor crystals as room temperature radiation detector. The Repeated Vertical Bridgman Technique was applied for the purification, based on the melting and nucleation phenomena. An ampoule filled with a maximum of 25% by volume of BiI{sub 3} powder was mounted into the Bridgman furnace and vertically moved at a speed of 2 millimeters per hour, inside the furnace with programmed thermal gradient and temperature profile, at a temperature maximum of 530 deg C. The reduction of the impurities in the BiI{sub 3}, each purification, was analysed by Instrumental Neutron Activation Analysis (INAA), in order to evaluate the efficiency of the purification technique established in this work, for trace metal impurities. It was demonstrated that the Repeated Bridgman is effective to reduce the concentration of many impurities in BiI{sub 3}, such as Ag, As, Br, Cr, K, Mo, Na and Sb. The crystalline structure of the BiI{sub 3} crystal purified twice and third times was similar to the BiI{sub 3} pattern. However, for BiI{sub 3} powder and purified once an intensity contribution of the BiOI was observed in the diffractograms. It is known that semiconductor detectors fabricated from high purity crystal exhibit significant improvement in their performance compared to those produced from low purity crystals. (author)

  17. New routes of preparation of polyaniline films and dosimetric characterization for high-doses gamma radiation; Novas rotas de preparacao de filmes de polianilina e caracterizacao dosimetrica para radiacao gama em altas doses

    Energy Technology Data Exchange (ETDEWEB)

    Pacheco, Ana Paula Lima

    2003-08-15

    This work presents a new conducting polymeric material based on polyaniline thin films that will be used in the confection of dosimetric devices. On preparation of the films a homogeneous and viscous solution of poly (acrylic acid) and MnO{sub 2} is deposited on PMMA surface, which after dried, is immersed in an acid aniline solution. The films formed present low resistivity (6.10{sup 2} {omega}m), good mechanical resistance and adherence on the electrodes. The films were characterized by infrared spectroscopy, conductivity measurements and manganese elemental analyses. The resistance variations show linear correlation (r{sup 2} = 0,9928) with gamma irradiation dose in the range of 1000 to 6000 Gy, with medium error less than 5% and sensitivity response. The dosimetric devices present as advantage real time measurements, low cost, use in calibration of industrial radioactive sources. Moreover, this composite could in future replace Fricke dosimeter and its applications. A calibration curve is showed for PANI dosimeter, here proposed, to use at high gamma doses. (author)

  18. Study on the energy dependence of gamma radiation detectors for {sup 137}Cs and {sup 60}Co; Estudo da dependencia energetica de detectores de radiacao gama para {sup 137}Cs e {sup 60}Co

    Energy Technology Data Exchange (ETDEWEB)

    Nonato, Fernanda B.C.; Diniz, Raphael E.; Carvalho, Valdir S.; Vivolo, Vitor; Caldas, Linda V.E., E-mail: fbnonato@ipen.b, E-mail: rediniz@ipen.b, E-mail: vcsouza@ipen.b, E-mail: vivolo@ipen.b, E-mail: lcaldas@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2009-07-01

    38 Geiger-Mueller radiation detectors and 9 ionization chambers were calibrated, viewing to study the energy dependence of the monitor response for gamma radiation fields ({sup 137}Cs and {sup 60}Co). The results were considered satisfactory only for ionization chambers and for some Geiger-Mueller detectors

  19. Determination of gamma radiation dose to the destruction of Escherichia coli O157: H7 in hamburger;Determinacao da dose de radiacao gama para a destruicao de Escherichia coli O157:H7 em hamburguer bovino

    Energy Technology Data Exchange (ETDEWEB)

    Orejuela Chirinos, Rodolfo Raul

    1999-07-01

    Escherichia coli O157:H7 has been incriminated in several foodborne outbreaks due to the consumption of different kinds of foods. Among these, hamburgers are the most common. Irradiation process is an effective method for food preservation because it causes no significant change in organoleptic and nutritional food characteristics and destroys pathogens and spoilage microorganisms. Hamburgers and nutrient broth inoculated with Escherichia coli O157:H7 were submitted to gamma irradiation ({sup 60}Co) treatment, with doses ranging from 0,0 to 0,7 kGy in order to calculate the D{sub 10} for this bacteria in these substrate. The D{sub 10} for the pathogen nutrient broth ranged from 0.08 kGy to 0.10 kGy and in hamburger from 0.11 kGy to 0.21 kGy. Considering the highest D{sub 10} value in hamburger, a dose of 0,8 kGy would not change the sensorial characteristics of the product, and would reduce the population of E. coli O157:H7 in 4 cycles logarithmic. (author)

  20. Sensor device for X-ray beam to evaluate the radiation focal spot; Dispositivo de sensoriamento do feixe de raios-X para determinacao do centro do campo de radiacao

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Lara H.E. dos; Schiabel, Homero; Silva, Aderbal A.B. da; Marques, Paulo M.A.; Campos, Marcelo; Slaets, Annie F.F. [Sao Paulo Univ., Sao Carlos, SP (Brazil). Escola de Engenharia. Dept. de Engenharia Eletrica

    1996-12-31

    A new electronic device to determine the position of the central ray of the radiation beam is proposed. The device aims to provide a perfect alignment of test objects used for evaluating focal spots with this reference axis 7 refs., 1 fig.

  1. Poly(vinylidene fluoride) modification induced by gamma irradiation for application as ionic polymer-metal composite; Modificacao de poli(fluoreto de vinilideno) induzida por radiacao gama para aplicacao como composito ionomerico de metal-polimero

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Henrique Perez

    2011-07-01

    Gamma-radiation-induced grafting of styrene into poly(vinylidene fluoride) (PVDF) films with 0.125 mm thickness at doses from 1 to 100 kGy in the presence of a styrene/N,N- dimethylformamide (DMF) solution (1:1, v/v) and styrene/toluene (1:1, v/v) at dose rate of 5 kGy h-1 was carried out by simultaneous method under nitrogen atmosphere at room temperature, using gamma rays from a Co-60. After grafting reactions, the polymer was then sulfonated in chlorosulfonic acid/1,2-dichloroethane (2 and 10%) for 3 hours. The films were characterized before and after modification by calculating the degree of grafting (DOG), infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and thermogravimetry (TG/DTG). DOG results show that grafting increases with dose, and varies enormously depending on the solvent used, with DOGs about 20 times greater in DMF than in toluene. It was possible to confirm the grafting of styrene by FT-IR due to the appearance of the new characteristic peaks and by the TG and DSC which exhibited changes in the thermal behavior of the grafted/sulfonated material. Sulfonated material was also characterized by ion exchange capacity (IEC) showed that both DOG and sulfonic acid concentration increase IEC values. Results showed that it is possible to obtain materials with ion exchange capacity of possible application as ionic polymer-metal composites. (author)

  2. Cloning and characterization of human liver cytosolic beta-glycosidase

    NARCIS (Netherlands)

    De Graaf, M; Van Veen, IC; Van Der Meulen-Muileman, IH; Gerritsen, WR; Pinedo, HM; Haisma, HJ

    2001-01-01

    Cytosolic beta -glucosidase (EC 3.2.1.21) from mammalian liver is a member of the family 1 glycoside hydrolases and is known for its ability to hydrolyse a range of beta -D-glycosides. including beta -D-glucoside acid beta -D-galactoside. We therefore refer to this enzyme as cytosolic beta

  3. Beta-glucosidase variants and polynucleotides encoding same

    Energy Technology Data Exchange (ETDEWEB)

    Wogulis, Mark; Harris, Paul; Osborn, David

    2017-06-27

    The present invention relates to beta-glucosidase variants, e.g. beta-glucosidase variants of a parent Family GH3A beta-glucosidase from Aspergillus fumigatus. The present invention also relates to polynucleotides encoding the beta-glucosidase variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the beta-glucosidase variants.

  4. Beta-glucosidase I variants with improved properties

    Science.gov (United States)

    Bott, Richard R.; Kaper, Thijs; Kelemen, Bradley; Goedegebuur, Frits; Hommes, Ronaldus Wilhelmus; Kralj, Slavko; Kruithof, Paulien; Nikolaev, Igor; Van Der Kley, Wilhelmus Antonious Hendricus; Van Lieshout, Johannes Franciscus Thomas; Van Stigt Thans, Sander

    2016-09-20

    The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase variants, compositions comprising beta-glucosidase variants, methods of using beta-glucosidase variants, and methods of identifying additional useful beta-glucosidase variants.

  5. Dosimetry of low-energy beta radiation

    Energy Technology Data Exchange (ETDEWEB)

    Borg, J.

    1996-08-01

    Useful techniques and procedures for determination of absorbed doses from exposure in a low-energy {beta} radiation field were studied and evaluated in this project. The four different techniques included were {beta} spectrometry, extrapolation chamber dosimetry, Monte Carlo (MC) calculations, and exoelectron dosimetry. As a typical low-energy {beta} radiation field a moderated spectrum from a {sup 14}C source (E{sub {beta}},{sub max} =156 keV) was chosen for the study. The measured response of a Si(Li) detector to photons (bremsstrahlung) showed fine agreement with the MC calculated photon response, whereas the difference between measured and MC calculated responses to electrons indicates an additional dead layer thickness of about 12 {mu}m in the Si(Li) detector. The depth-dose profiles measured with extrapolation chambers at two laboratories agreed very well, and it was confirmed that the fitting procedure previously reported for {sup 147}Pm depth-dose profiles is also suitable for {beta} radiation from {sup 14}C. An increasing difference between measured and MC calculated dose rates for increasing absorber thickness was found, which is explained by limitations of the EGS4 code for transport of very low-energy electrons (below 10-20 keV). Finally a study of the thermally stimulated exoelectron emission (TSEE) response of BeO thin film dosemeters to {beta} radiation for radiation fields with maximum {beta} energies ranging from 67 keV to 2.27 MeV is reported. For maximum {beta} energies below approximately 500 keV, a decrease in the response amounting to about 20% was observed. It is thus concluded that a {beta} dose higher than about 10 {mu}Gy can be measured with these dosemeters to within 0 to -20% independently of the {beta}energy for E{sub {beta}},{sub max} values down to 67 keV. (au) 12 tabs., 38 ills., 71 refs.

  6. Rat pancreatic beta cells and cytomegalovirus infection.

    Science.gov (United States)

    Smelt, Maaike J; Faas, Marijke M; de Haan, Bart J; Hofstede, Jeroen; Cheung, Chi-Wai; van der Iest, Hanna; de Haan, Aalzen; de Vos, Paul

    2010-01-01

    Cytomegalovirus (CMV) infection has been suggested to accelerate beta-cell destruction and thereby to contribute to new-onset diabetes and failure of islet allografts in both humans and rodents. Surprisingly, direct CMV infection of beta cells has received only minor attention. Therefore, we investigated the susceptibility of rat beta cells for rat CMV (RCMV) infection and the direct effects on the regulation of immune cell-activating ligands. Primary rat beta cells, the rat beta-cell line Rin-m5F, and fibroblasts were RCMV-infected in vitro. The viral gene and protein expression levels were determined as a measure for RCMV susceptibility. Gene expression levels of intracellular adhesion molecule 1, lymphocyte function associated antigen 3, rat major histocompatibility complex region A, rat major histocompatibility complex region E, toll like receptor 2, and clustered domain 14 were determined as a measure for cellular immunogenicity. We demonstrate that beta cells are susceptible for RCMV infection but allow only low levels of viral gene expression. In contrast, infected fibroblasts demonstrated productive viral infection and formation of viral progeny. After RCMV infection, beta-cell immunogenicity was markedly increased, as demonstrated by the increased cellular expression of immune cell-activating ligands. Direct beta-cell infection by RCMV and subsequent low-grade viral gene expression may lead to increased immunogenicity of native or transplanted beta cells in vivo. An infection-induced enhanced beta-cell recognizability may have important consequences for beta-cell survival and the development of diabetes or rejection of islet grafts.

  7. Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4

    DEFF Research Database (Denmark)

    Richter, Wito; Day, Peter; Agrawal, Rani

    2008-01-01

    Beta1- and beta2-adrenergic receptors (betaARs) are highly homologous, yet they play clearly distinct roles in cardiac physiology and pathology. Myocyte contraction, for instance, is readily stimulated by beta1AR but not beta2AR signaling, and chronic stimulation of the two receptors has opposing...

  8. Genetics Home Reference: beta-ureidopropionase deficiency

    Science.gov (United States)

    ... have been described in the medical literature. In Japan, the prevalence of beta-ureidopropionase deficiency has been ... damage caused by toxins, inflammation, and other factors. Research suggests that beta-alanine is involved in ... this site should not be used as a substitute for professional medical care or advice. Users with questions about a ...

  9. Nebivolol : third-generation beta-blockade

    NARCIS (Netherlands)

    de Boer, Rudolf A.; Voors, Adriaan A.; van Veldhuisen, Dirk J.

    Nebivolol is a third generation beta-blocker. It is highly selective for the beta 1-adrenoceptor, and has additional nitric oxide-mediated vasodilating and antioxidant properties, along with a favourable metabolic profile. Nebivolol is well tolerated by patients with hypertension and heart failure.

  10. Expression of transforming growth factor-beta (TGF-beta) receptors, TGF-beta 1 and TGF-beta 2 production and autocrine growth control in osteosarcoma cells

    NARCIS (Netherlands)

    Kloen, P.; Jennings, C. L.; Gebhardt, M. C.; Springfield, D. S.; Mankin, H. J.

    1994-01-01

    Transforming growth factor-beta (TGF-beta) is a polypeptide with multiple physiological functions. Isoforms of this growth factor have important roles in control of the cell cycle, in regulation of cell-cell interactions and in growth and development. Malignant transformation has been shown to be

  11. Topical beta-blockers and mortality

    NARCIS (Netherlands)

    Müskens, Rogier P. H. M.; Wolfs, Roger C. W.; Witteman, Jacqueline C. M.; Hofman, Albert; de Jong, Paulus T. V. M.; Stricker, Bruno H. C.; Jansonius, Nomdo M.

    2008-01-01

    To study the associations between long-term and short-term use of topical beta-blockers and mortality. Prospective population-based cohort study. To examine long-term effects, 3842 participants aged 55 years and older were recruited. To examine short-term effects, 484 incident beta-blocker users and

  12. Beta-2-mikroglobulin ved medicinske sygdomme

    DEFF Research Database (Denmark)

    Hansen, P B; Olsen, Niels Vidiendal

    1989-01-01

    Beta-2-microglobulin (beta 2M) is a low-molecular protein which is filtered freely over the glomeruli. Under normal circumstances, more than 99.9% is resorbed in the proximal tubuli of the kidneys and is metabolized there. In renal disease with damage to this segment of the nephron, eg acute tubulo...

  13. Localization of thymosin beta-4 in tumors

    DEFF Research Database (Denmark)

    Larsson, L. -I.; Holck, Susanne

    2007-01-01

    Overexpression of thymosin beta-4 has been linked to malignant progression but the localization of this polypeptide within tumors is incompletely known. We therefore examined breast cancers for thymosin beta-4 using immunofluorescence. Reactive cells were identified with monoclonal cell marker...... in the tumor microenvironment may modulate tumor behavior....

  14. High power beta electron device - Beyond betavoltaics.

    Science.gov (United States)

    Ayers, William M; Gentile, Charles A

    2018-01-01

    Developing watt level power sources with beta emitting radioisotopes has been limited by the inability to utilize high energy (> 100KeV) beta emitters at high radioisotope loadings without damaging the energy conversion materials. A new type of beta electron power source is described that removes those restrictions. The approach contains the radioisotope in a beta transparent titanium tube and confines beta electrons emitted through the tube wall to spiral trajectories around the tube with an axial magnetic field. The confined beta electrons dissipate energy though multiple interactions with surrounding excimer precursor gas atoms to efficiently generate photons. Photovoltaic cells convert the photons to electrical power. Since the beta electrons dissipate energy in the excimer precursor gas, the device can be loaded with more than 1013Bq of radioisotope to generate 100 milliwatt to watt levels of electrical power without damaging the device materials or degrading its performance. The power source can use a variety of beta radioisotopes and scales by stacking the devices. Copyright © 2017. Published by Elsevier Ltd.

  15. Expression of transforming growth factor beta (TGF beta) receptors and expression of TGF beta 1, TGF beta 2 and TGF beta 3 in human small cell lung cancer cell lines

    DEFF Research Database (Denmark)

    Damstrup, L; Rygaard, K; Spang-Thomsen, M

    1993-01-01

    A panel of 21 small cell lung cancer cell (SCLC) lines were examined for the presence of Transforming growth factor beta receptors (TGF beta-r) and the expression of TGF beta mRNAs. By the radioreceptor assay we found high affinity receptors to be expressed in six cell lines. scatchard analysis...

  16. Expression of transforming growth factor beta (TGF beta) receptors and expression of TGF beta 1, TGF beta 2 and TGF beta 3 in human small cell lung cancer cell lines.

    Science.gov (United States)

    Damstrup, L; Rygaard, K; Spang-Thomsen, M; Skovgaard Poulsen, H

    1993-05-01

    A panel of 21 small cell lung cancer cell (SCLC) lines were examined for the presence of Transforming growth factor beta receptors (TGF beta-r) and the expression of TGF beta mRNAs. By the radioreceptor assay we found high affinity receptors to be expressed in six cell lines. scatchard analysis of the binding data demonstrated that the cells bound between 4.5 and 27.5 fmol mg-1 protein with a KD ranging from 16 to 40 pM. TGF beta 1 binding to the receptors was confirmed by cross-linking TGF beta 1 to the TGF beta-r. Three classes of TGF beta-r were demonstrated, type I and type II receptors with M(r) = 65,000 and 90,000 and the betaglycan (type III) with M(r) = 280,000. Northern blotting showed expression of TGF beta 1 mRNA in ten, TGF beta 2 mRNA in two and TGF beta 3 mRNA in seven cell lines. Our results provide, for the first time, evidence that a large proportion of a broad panel of SCLC cell lines express TGF beta-receptors and also produce TGF beta mRNAs.

  17. Higher-Order Beta Matching with Solutions in Long Beta-Eta Normal Form

    DEFF Research Database (Denmark)

    Støvring, Kristian

    2006-01-01

    Higher-order matching is a special case of unification of simply-typed lambda-terms: in a matching equation, one of the two sides contains no unification variables. Loader has recently shown that higher-order matching up to beta equivalence is undecidable, but decidability of higher-order matching...... up to beta-eta equivalence is a long-standing open problem.We show that higher-order matching up to beta-eta equivalence is decidable if and only if a restricted form of higher-order matching up to beta equivalence is decidable: the restriction is that solutions must be in long beta-eta normal form....

  18. $\\beta$ decay of $^{47}$Ar

    CERN Document Server

    Weissman, L; Bergmann, U C; Brown, B A; Catherall, R; Cederkäll, J; Dillmann, I; Hallmann, O; Fraile-Prieto, L M; Franchoo, S; Gaudefroy, L; Köster, U; Kratz, K L; Pfeiffer, B; Sorlin, O; 10.1103/PhysRevC.70.024304

    2004-01-01

    Information on beta -decay properties of neutron-rich /sup 47/Ar was obtained at the ISOLDE facility at CERN using isobaric selectivity. This was achieved by a combination of a plasma-ion source with a cooled transfer line and subsequent mass separation. A doubly charged beam was used in order to improve the signal-to-background ratio associated with multi-charged noble gas fission products. The identification of the /sup 47/Ar gamma -ray transitions was performed by comparing the spectra obtained from direct proton bombardment of the target and of the neutron converter. New excited levels in the daughter /sup 47/K nucleus corresponding to the negative-parity states were observed. The obtained data are compared to the result of large-scale shell model calculations and quasiparticle random-phase approximation predictions. (29 refs).

  19. Beta cell proliferation and growth factors

    DEFF Research Database (Denmark)

    Nielsen, Jens Høiriis; Svensson, C; Møldrup, Annette

    1999-01-01

    Formation of new beta cells can take place by two pathways: replication of already differentiated beta cells or neogenesis from putative islet stem cells. Under physiological conditions both processes are most pronounced during the fetal and neonatal development of the pancreas. In adulthood little...... increase in the beta cell number seems to occur. In pregnancy, however, a marked hyperplasia of the beta cells is observed both in rodents and man. Increased mitotic activity has been seen both in vivo and in vitro in islets exposed to placental lactogen (PL), prolactin (PRL) and growth hormone (GH...... cloned a novel GH/PRL stimulated rat islet gene product, Pref-1 (preadipocyte factor-1). This protein contains six EGF-like motifs and may play a role both in embryonic pancreas differentiation and in beta cell growth and function. In summary, the increasing knowledge about the mechanisms involved...

  20. Ranking beta sheet topologies of proteins

    DEFF Research Database (Denmark)

    Fonseca, Rasmus; Helles, Glennie; Winter, Pawel

    2010-01-01

    One of the challenges of protein structure prediction is to identify long-range interactions between amino acids. To reliably predict such interactions, we enumerate, score and rank all beta-topologies (partitions of beta-strands into sheets, orderings of strands within sheets and orientations...... of paired strands) of a given protein. We show that the beta-topology corresponding to the native structure is, with high probability, among the top-ranked. Since full enumeration is very time-consuming, we also suggest a method to deal with proteins with many beta-strands. The results reported...... in this paper are highly relevant for ab initio protein structure prediction methods based on decoy generation. The top-ranked beta-topologies can be used to find initial conformations from which conformational searches can be started. They can also be used to filter decoys by removing those with poorly...

  1. Antibodies against chromosomal beta-lactamase

    DEFF Research Database (Denmark)

    Giwercman, B; Rasmussen, J W; Ciofu, Oana

    1994-01-01

    A murine monoclonal anti-chromosomal beta-lactamase antibody was developed and an immunoblotting technique was used to study the presence of serum and sputum antibodies against Pseudomonas aeruginosa chromosomal group 1 beta-lactamase in patients with cystic fibrosis (CF). The serum antibody...... response was studied with serum samples collected in 1992 from 56 CF patients in a cross-sectional study and with serum samples from 18 CF patients in a longitudinal study. Anti-beta-lactamase immunoglobulin G antibodies were present in all of the serum samples from the patients with chronic...... bronchopulmonary P. aeruginosa infection (CF + P) but in none of the CF patients with no or intermittent P. aeruginosa infection. Anti-beta-lactamase antibodies were present in serum from CF + P patients after six antipseudomonal courses (median) and correlated with infection with a beta-lactam-resistant strain...

  2. Beta cell dysfunction and insulin resistance

    Directory of Open Access Journals (Sweden)

    Marlon E Cerf

    2013-03-01

    Full Text Available Beta cell dysfunction and insulin resistance are inherently complex with their interrelation for triggering the pathogenesis of diabetes also somewhat undefined. Both pathogenic states induce hyperglycemia and therefore increase insulin demand. Beta cell dysfunction results from inadequate glucose sensing to stimulate insulin secretion therefore elevated glucose concentrations prevail. Persistently elevated glucose concentrations above the physiological range result in the manifestation of hyperglycemia. With systemic insulin resistance, insulin signaling within glucose recipient tissues is defective therefore hyperglycemia perseveres. Beta cell dysfunction supersedes insulin resistance in inducing diabetes. Both pathological states influence each other and presumably synergistically exacerbate diabetes. Preserving beta cell function and insulin signaling in beta cells and insulin signaling in the glucose recipient tissues will maintain glucose homeostasis.

  3. Clusters of conserved beta cell marker genes for assessment of beta cell phenotype

    DEFF Research Database (Denmark)

    Martens, Geert A; Jiang, Lei; Hellemans, Karine H

    2011-01-01

    The aim of this study was to establish a gene expression blueprint of pancreatic beta cells conserved from rodents to humans and to evaluate its applicability to assess shifts in the beta cell differentiated state. Genome-wide mRNA expression profiles of isolated beta cells were compared to those...... of a large panel of other tissue and cell types, and transcripts with beta cell-abundant and -selective expression were identified. Iteration of this analysis in mouse, rat and human tissues generated a panel of conserved beta cell biomarkers. This panel was then used to compare isolated versus laser capture...... microdissected beta cells, monitor adaptations of the beta cell phenotype to fasting, and retrieve possible conserved transcriptional regulators....

  4. Computational prediction of alpha/beta selectivities in the pyrolysis of oxygen-substituted phenethyl phenyl ethers.

    Science.gov (United States)

    Beste, Ariana; Buchanan, A C; Harrison, Robert J

    2008-06-05

    Phenethyl phenyl ether (PPE; PhCH 2CH 2OPh) is the simplest model for the most common beta-O-4 linkage in lignin. Previously, we developed a computational scheme to calculate the alpha/beta product selectivity in the pyrolysis of PPE by systematically exploiting error cancellation in the computation of relative rate constants. The alpha/beta selectivity is defined as the selectivity between the competitive hydrogen abstraction reaction paths on the alpha- and beta-carbons of PPE. We use density functional theory and employ transition state theory where we include diagonal anharmonic correction in the vibrational partition functions for low frequency modes for which a semiclassical expression is used. In this work we investigate the effect of oxygen substituents (hydroxy, methoxy) in the para position on the phenethyl ring of PPE on the alpha/beta selectivities. The total alpha/beta selectivity increases when substituents are introduced and is larger for the methoxy than the hydroxy substituent. The strongest effect of the substituents is observed for the alpha-pathway of the hydrogen abstraction by the phenoxyl chain carrying radical for which the rate increases. For the beta pathway and the abstraction by the R-benzyl radical (R = OH,OCH 3) the rate decreases with the introduction of the substituents. These findings are compared with results from recent experimental studies.

  5. Dimers of beta 2-glycoprotein I mimic the in vitro effects of beta 2-glycoprotein I-anti-beta 2-glycoprotein I antibody complexes

    NARCIS (Netherlands)

    Lutters, B. C.; Meijers, J. C.; Derksen, R. H.; Arnout, J.; de Groot, P. G.

    2001-01-01

    Anti-beta(2)-glycoprotein I antibodies are thought to cause lupus anticoagulant activity by forming bivalent complexes with beta(2)-glycoprotein I (beta(2)GPI). To test this hypothesis, chimeric fusion proteins were constructed of the dimerization domain (apple 4) of factor XI and beta(2)GPI. Both a

  6. Role of Transforming Growth Factor Beta in Human Cancer

    National Research Council Canada - National Science Library

    Rebecca L. Elliott; Gerard C. Blobe

    2005-01-01

    Transforming growth factor beta (TGF-beta) is a ubiquitous and essential regulator of cellular and physiologic processes including proliferation, differentiation, migration, cell survival, angiogenesis, and immunosurveillance...

  7. Significance of alpha 9 beta 1 and alpha v beta 6 integrin expression in breast carcinoma.

    Science.gov (United States)

    Arihiro, K; Kaneko, M; Fujii, S; Inai, K; Yokosaki, Y

    2000-01-01

    Both alpha 9 beta 1 and alpha v beta 6 integrins have been newly identified from the tracheal epithelium of guinea pig. It has been pointed out that alpha 9 beta 1 functions as a receptor for tenascin-C and osteopontin. As for the ligands of alpha v beta 6, fibronectin and tenascin-C have been identified. It has not been ascertained whether alpha 9 beta 1 and alpha v beta 6 are expressed in normal breast tissue, benign breast lesion or breast carcinoma. Immunohistochemical staining for alpha 9 beta 1 and alpha v beta 6 was performed in benign breast lesion and breast carcinoma specimens. Western blotting was carried out on 11 breast carcinoma cases. alpha 9 beta 1 was expressed in the cytoplasm of carcinoma cells in 23 of 90 cases (26%) and alpha v beta 6 in the membrane of carcinoma cells in 16 of 90 cases (18%). However, these findings of alpha 9 beta 1 and alpha v beta 6 did not correlate with any clinicopathological factors including the patients' age, tumor size, histological type of carcinoma, location of carcinoma cells and hormone receptor status. With regard to the histological grade of carcinoma, alpha v beta 6 and alpha 9 beta 1 expression did not statistically correlate, although no expression of alpha v beta 6 was observed in 14 cases of Grade I. On Western-blott analysis strong and weak bands consistent with alpha v beta 6 were noted in the membrane fraction extracted from breast carcinoma cells. On the other hand weak bands consistent with alpha 9 subunit were noted in the whole cell lysates of breast carcinoma cells and very weak or no bands consistent with alpha 9 subunit were noted in the membrane fraction extracted from the breast carcinoma cells. Significance of alpha 9 beta 1 and alpha v beta 6 integrins expression in breast carcinoma was still unknown on clinicopathological examination. The findings of Western blot analysis may indicate that the transportation system of glycoproteins such as integrins to the cell membrane of carcinoma cells is

  8. Ellagic acid promotes A{beta}42 fibrillization and inhibits A{beta}42-induced neurotoxicity

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Ying [Department of Histology and Embryology, College of Basic Medical Science, China Medical University, Shenyang 110001 (China); Tsinghua University School of Medicine, Haidian District, Beijing 100084 (China); Yang, Shi-gao; Du, Xue-ting; Zhang, Xi; Sun, Xiao-xia; Zhao, Min [Tsinghua University School of Medicine, Haidian District, Beijing 100084 (China); Sun, Gui-yuan, E-mail: sungy2004@sohu.com [Department of Histology and Embryology, College of Basic Medical Science, China Medical University, Shenyang 110001 (China); Liu, Rui-tian, E-mail: rtliu@tsinghua.edu.cn [Tsinghua University School of Medicine, Haidian District, Beijing 100084 (China)

    2009-12-25

    Smaller, soluble oligomers of {beta}-amyloid (A{beta}) play a critical role in the pathogenesis of Alzheimer's disease (AD). Selective inhibition of A{beta} oligomer formation provides an optimum target for AD therapy. Some polyphenols have potent anti-amyloidogenic activities and protect against A{beta} neurotoxicity. Here, we tested the effects of ellagic acid (EA), a polyphenolic compound, on A{beta}42 aggregation and neurotoxicity in vitro. EA promoted A{beta} fibril formation and significant oligomer loss, contrary to previous results that polyphenols inhibited A{beta} aggregation. The results of transmission electron microscopy (TEM) and Western blot displayed more fibrils in A{beta}42 samples co-incubated with EA in earlier phases of aggregation. Consistent with the hypothesis that plaque formation may represent a protective mechanism in which the body sequesters toxic A{beta} aggregates to render them harmless, our MTT results showed that EA could significantly reduce A{beta}42-induced neurotoxicity toward SH-SY5Y cells. Taken together, our results suggest that EA, an active ingredient in many fruits and nuts, may have therapeutic potential in AD.

  9. Tau overexpression in transgenic mice induces glycogen synthase kinase 3beta and beta-catenin phosphorylation.

    Science.gov (United States)

    Shim, S B; Lim, H J; Chae, K R; Kim, C K; Hwang, D Y; Jee, S W; Lee, S H; Sin, J S; Leem, Y H; Lee, S H; Cho, J S; Lee, H H; Choi, S Y; Kim, Y K

    2007-05-11

    The abnormal phosphorylations of tau, GSK3beta, and beta-catenin have been shown to perform a crucial function in the neuropathology of Alzheimer's disease (AD). The primary objective of the current study was to determine the manner in which overexpressed htau23 interacts and regulates the behavior and phosphorylation characteristics of tau, GSK3beta, and beta-catenin. In order to accomplish this, transgenic mice expressing neuron-specific enolase (NSE)-controlled human wild-type tau (NSE/htau23) were created. Transgenic mice evidenced the following: (i) tendency toward memory impairments at later stages, (ii) dramatic overexpression of the tau transgene, coupled with increased tau phosphorylation and paired helical filaments (PHFs), (iii) high levels of GSK3beta phosphorylation with advanced age, resulting in increases in the phosphorylations of tau and beta-catenin, (iv) an inhibitory effect of lithium on the phosphorylations of tau, GSK3beta, and beta-catenin, but not in the non-transgenic littermate group. Therefore, the overexpression of NSE/htau23 in the brains of transgenic mice induces abnormal phosphorylations of tau, GSK3beta, and beta-catenin, which are ultimately linked to neuronal degeneration in cases of AD. These transgenic mice are expected to prove useful for the development of new drugs for the treatment of AD.

  10. An imidazoline compound completely counteracts interleukin-1[beta] toxic effects to rat pancreatic islet [beta] cells.

    Science.gov (United States)

    Papaccio, Gianpaolo; Nicoletti, Ferdinando; Pisanti, Francesco A; Galdieri, Michela; Bendtzen, Klaus

    2002-09-01

    In vitro studies have demonstrated that interleukin (IL)-1beta decreases insulin and DNA contents in pancreatic islet beta cells, causing structural damage, that it is toxic to cultured human islet beta cells and that it is able to induce apoptosis in these cells. Isolated rat islets of Langerhans were exposed in vitro to interleukin (IL)-1beta and either the imidazoline compound RX871024 (RX) or/and M40403, an Mn-containing superoxide dismutase mimetic (MnSODm). Insulin secretion, on days 1, 2 and 3 after challenge with 3 ng/ml of IL-1beta, was almost abolished and this was accompanied by an early increase in MnSOD activity. By days 2 and 3, SOD activities were lower than those of untreated controls and NO significantly increased by day 2. Moreover, IL-1beta induced a significant increase in MnSOD transcripts, while iNOS mRNA appeared by days 2 and 3 when MnSOD mRNA was absent. RX blocked all toxic effects of IL-1beta by maintaining insulin secretion and islet beta cell phenotype, including the inhibition of nonspecific proteins and of iNOS induction. In contrast, the MnSODm, failed to counteract iNOS induction as well as the reduced insulin secretion. In summary, our findings stress that IL-1beta-induced suppression of insulin secretion may be related to iNOS induction in beta cells and that RX can reverse this effect, by maintaining insulin secretion. Oppositely, the MnSODm is not able to restore IL-1beta-suppressed insulin secretion. Hence, imidazoline compounds may protect beta cells against damage caused by IL-1beta-induced free oxygen and nitrogen radicals.

  11. The theory of beta-decay

    CERN Document Server

    Strachan, Charles

    1969-01-01

    The Theory of Beta-Decay covers the formulas, theories, probabilities, and spectra of beta-decay. This book is divided into 2 parts compassing 12 chapters, and starts with the introduction to the neutrino and the quantum theoretical background, explaining the basic phenomenon of beta-decay and the emission of electrons. The subsequent chapters deal with the interaction and the transition probability, as well as formulas of solutions. These topics are followed by discussions on the developments in the non-conservation of parity and helicity, the two-component theory of the neutrino, possible i

  12. Silent ischemia and beta-blockade

    DEFF Research Database (Denmark)

    Egstrup, K

    1991-01-01

    and should also be directed at the other coronary artery risk factors of the patients. The effects of beta-blockers, which reduce the duration and frequency of silent ischemic episodes, is well described. The effect is most pronounced in the morning, when the frequency of ischemia is highest......, and the mechanism of action seems mainly mediated through a reduction in myocardial oxygen demand. beta-Blockers have shown effectiveness in both effort-induced angina and mixed angina, and increased anti-ischemic potency may be achieved by combination therapy with a calcium antagonist. Abrupt withdrawal of beta-blockers...

  13. Dosimetry of Low-Energy Beta Radiation

    DEFF Research Database (Denmark)

    Borg, Jette

    Useful techniques and procedures for derermination of absorbed doses from exposure in a low-energy beta radiation were studied and evaluated. The four techniques included were beta spectrometry, extrapolation chamber dosimetry, Monte Carlo (MC) calculations, and exoelectron dosimetry. As a typical...... low-energy beta radiation field a moderated spectrum from a carbon-14 source was used. The measured responce of a Si(Li) detector to photons (bremsstrahlung) showed fine agreemant with the MC calculated photon response, whereas the difference between measured and MC calculated response to electrons...

  14. HMX Polymorphs: Gamma to Beta Phase Transformation

    Science.gov (United States)

    Soni, Pramod; Sarkar, C.; Tewari, R.; Sharma, T. D.

    2011-07-01

    The process of conversion of a gamma (γ) polymorph of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) to a beta (β) polymorph is a challenging one. In order to obtain beta HMX from gamma HMX, a novel and economical method, using hot water, has been developed. The characterization of beta HMX using thermo-gravimetric and differential thermal analysis, high-performance liquid chromatography (HPLC), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and impact sensitivity has been carried out toward its use for various military applications including advanced propellant formulation.

  15. Modelos de cálculo de las betas a aplicar en el Capital Asset Pricing Model: el caso de Argentina

    Directory of Open Access Journals (Sweden)

    Carlos E. Martínez

    2014-01-01

    Full Text Available Producto de una revisión de la literatura, en el presente trabajo se aplican 4 métodos para el cálculo de las betas de una muestra de 11 compañías que entre 2010 y 2012 cotizaron en el Mercado de Valores de Argentina. Empleando cada método, se identifica aquel que puede ser tomado como referencia para determinar las betas de pequeñas y medianas empresas (Pymes que no cotizan en la Bolsa de Valores. Se concluye que para calcular los valores de las betas e interpretar el riesgo de cada empresa resulta necesario analizar técnicamente el método utilizado y la variabilidad de las series temporales empleadas, además de conocer las perspectivas futuras tanto de la empresa analizada como del sector al cual pertenece.

  16. Modelos de cálculo de las betas a aplicar en el Capital Asset Pricing Model: el caso de Argentina

    Directory of Open Access Journals (Sweden)

    Carlos E. Martínez

    2014-04-01

    Full Text Available Producto de una revisión de la literatura, en el presente trabajo se aplican 4 métodos para el cálculo de las betas de una muestra de 11 compañías que entre 2010 y 2012 cotizaron en el Mercado de Valores de Argentina. Empleando cada método, se identifica aquel que puede ser tomado como referencia para determinar las betas de pequeñas y medianas empresas (Pymes que no cotizan en la Bolsa de Valores. Se concluye que para calcular los valores de las betas e interpretar el riesgo de cada empresa resulta necesario analizar técnicamente el método utilizado y la variabilidad de las series temporales empleadas, además de conocer las perspectivas futuras tanto de la empresa analizada como del sector al cual pertenece.

  17. BETA-AMYLOID AS PATHOGENESIS OF ALZHEIMER DISEASE

    Directory of Open Access Journals (Sweden)

    Kadek Ary Mahendri Pattni

    2013-07-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE Alzheimer disease is often causing cognitive decline in elder population. The incidence of this disease is increasing by the age, about 0,3% to 0,6% it affects individuals aged 65 to 69 years, and 5,3% - 7,5% affects individuals aged 65 to 69 years. Alzheimer also affects individuals aged less then 65 years and known as early onset of Alzheimer disease that is caused by increasing of Beta-Amyloid aggregation from the mutation of amyloid precursor protein (APP. From the accumulation of this substance may trigger the cascade lost of some synaps in the brain and arising Alzheimer type of Dementia. /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

  18. Beta cell count instead of beta cell mass to assess and localize growth in beta cell population following pancreatic duct ligation in mice.

    Directory of Open Access Journals (Sweden)

    Marie Chintinne

    Full Text Available BACKGROUND: Pancreatic-tail duct ligation (PDL in adult rodents has been reported to induce beta cell generation and increase beta cell mass but increases in beta cell number have not been demonstrated. This study examines whether PDL increases beta cell number and whether this is caused by neogenesis of small clusters and/or their growth to larger aggregates. METHODOLOGY: Total beta cell number and its distribution over small (100 µm clusters was determined in pancreatic tails of 10-week-old mice, 2 weeks after PDL or sham. PRINCIPAL FINDINGS: PDL increased total beta cell mass but not total beta cell number. It induced neogenesis of small beta cell clusters (2.2-fold higher number which contained a higher percent proliferating beta cells (1.9% Ki67+cells than sham tails (<0.2%; their higher beta cell number represented <5% of total beta cell number and was associated with a similar increase in alpha cell number. It is unknown whether the regenerative process is causally related to the inflammatory infiltration in PDL-tails. Human pancreases with inflammatory infiltration also exhibited activation of proliferation in small beta cell clusters. CONCLUSIONS/SIGNIFICANCE: The PDL model illustrates the advantage of direct beta cell counts over beta cell mass measurements when assessing and localizing beta cell regeneration in the pancreas. It demonstrates the ability of the adult mouse pancreas for neogenesis of small beta cell clusters with activated beta cell proliferation. Further studies should investigate conditions under which neoformed small beta cell clusters grow to larger aggregates and hence to higher total beta cell numbers.

  19. Dopamine beta-hydroxylase deficiency

    Directory of Open Access Journals (Sweden)

    Senard Jean-Michel

    2006-03-01

    Full Text Available Abstract Dopamine beta-hydroxylase (DβH deficiency is a very rare form of primary autonomic failure characterized by a complete absence of noradrenaline and adrenaline in plasma together with increased dopamine plasma levels. The prevalence of DβH deficiency is unknown. Only a limited number of cases with this disease have been reported. DβH deficiency is mainly characterized by cardiovascular disorders and severe orthostatic hypotension. First symptoms often start during a complicated perinatal period with hypotension, muscle hypotonia, hypothermia and hypoglycemia. Children with DβH deficiency exhibit reduced ability to exercise because of blood pressure inadaptation with exertion and syncope. Symptoms usually worsen progressively during late adolescence and early adulthood with severe orthostatic hypotension, eyelid ptosis, nasal stuffiness and sexual disorders. Limitation in standing tolerance, limited ability to exercise and traumatic morbidity related to falls and syncope may represent later evolution. The syndrome is caused by heterogeneous molecular alterations of the DBH gene and is inherited in an autosomal recessive manner. Restoration of plasma noradrenaline to the normal range can be achieved by therapy with the synthetic precursor of noradrenaline, L-threo-dihydroxyphenylserine (DOPS. Oral administration of 100 to 500 mg DOPS, twice or three times daily, increases blood pressure and reverses the orthostatic intolerance.

  20. Energetic, Structural, and Antimicrobial Analyses of [beta]-Lactam Side Chain Recognition by [beta]-Lactamases

    Energy Technology Data Exchange (ETDEWEB)

    Caselli, E.; Powers, R.A.; Blaszczak, L.C.; Wu, C.Y.E.; Prati, F.; Shoichet, B.K. (NWU)

    2010-03-05

    Penicillins and cephalosporins are among the most widely used and successful antibiotics. The emergence of resistance to these {beta}-lactams, most often through bacterial expression of {beta}-lactamases, threatens public health. To understand how {beta}-lactamases recognize their substrates, it would be helpful to know their binding energies. Unfortunately, these have been difficult to measure because {beta}-lactams form covalent adducts with {beta}-lactamases. This has complicated functional analyses and inhibitor design. To investigate the contribution to interaction energy of the key amide (R1) side chain of {beta}-lactam antibiotics, eight acylglycineboronic acids that bear the side chains of characteristic penicillins and cephalosporins, as well as four other analogs, were synthesized. These transition-state analogs form reversible adducts with serine {beta}-lactamases. Therefore, binding energies can be calculated directly from K{sub i} values. The K{sub i} values measured span four orders of magnitude against the Group I {beta}-lactamase AmpC and three orders of magnitude against the Group II {beta}-lactamase TEM-1. The acylglycineboronic acids have K{sub i} values as low as 20 nM against AmpC and as low as 390 nM against TEM-1. The inhibitors showed little activity against serine proteases, such as chymotrypsin. R1 side chains characteristic of {beta}-lactam inhibitors did not have better affinity for AmpC than did side chains characteristic of {beta}-lactam substrates. Two of the inhibitors reversed the resistance of pathogenic bacteria to {beta}-lactams in cell culture. Structures of two inhibitors in their complexes with AmpC were determined by X-ray crystallography to 1.90 {angstrom} and 1.75 {angstrom} resolution; these structures suggest interactions that are important to the affinity of the inhibitors. Acylglycineboronic acids allow us to begin to dissect interaction energies between {beta}-lactam side chains and {beta}-lactamases. Surprisingly

  1. Literature in Focus Beta Beams: Neutrino Beams

    CERN Multimedia

    2009-01-01

    By Mats Lindroos (CERN) and Mauro Mezzetto (INFN Padova, Italy) Imperial Press, 2009 The beta-beam concept for the generation of electron neutrino beams was first proposed by Piero Zucchelli in 2002. The idea created quite a stir, challenging the idea that intense neutrino beams only could be produced from the decay of pions or muons in classical neutrino beams facilities or in future neutrino factories. The concept initially struggled to make an impact but the hard work by many machine physicists, phenomenologists and theoreticians over the last five years has won the beta-beam a well-earned position as one of the frontrunners for a possible future world laboratory for high intensity neutrino oscillation physics. This is the first complete monograph on the beta-beam concept. The book describes both technical aspects and experimental aspects of the beta-beam, providing students and scientists with an insight into the possibilities o...

  2. Genetics Home Reference: beta-mannosidosis

    Science.gov (United States)

    ... KH. Beta-mannosidosis mice: a model for the human lysosomal storage disease. Hum Mol Genet. 2006 Feb 1;15(3):493-500. Epub 2005 Dec 23. ... Features What are genome editing and CRISPR-Cas9? What ...

  3. Allergic reactions to beta-lactams.

    Science.gov (United States)

    Rodriguez-Pena, Rebeca; Antunez, Cristina; Martin, Enrique; Blanca-Lopez, Natalia; Mayorga, Cristobalina; Torres, Maria Jose

    2006-01-01

    Allergy to beta-lactam antibiotics is the most frequent cause of drug-induced immunological reactions, although the prevalence is not exactly known. IgE- and T-cell-dependent responses are the main mechanisms involved, although other immunological mechanisms can also participate, especially in haematological abnormalities, such as immune haemolytic anaemia or thrombocytopoenia. Aside from their frequency, the clinical entities reported nowadays have changed little since penicillin was first used. The variation in beta-lactams consumption through the year has modified the pattern and specificities of allergic reactions for IgE and T cell responses. Benzylpenicillin is no longer the beta-lactams most frequently prescribed and other chemical structures, with new or modified haptens, have progressively replaced it. This is relevant for the diagnostic evaluation and management of beta-lactam hypersensitivity.

  4. Beta-lactamase activity in Shigella sonnei.

    Science.gov (United States)

    Prince, A; Neu, H C

    1976-05-01

    The basis of ampicillin resistance in Shigella sonnei was analyzed for a number of isolates. Most isolates that were resistant to ampicillin and cephalothin failed to transfer resistance. Isolates resistant to cephalothin and ampicillin were inhibited by mecillinam, cefamandole, and cefoxitin. Six strains were selected for study. These differed on the basis of inhibition by 10 beta-lactam antibiotics and on differences in beta-lactamase activity. There was no correlation between the inhibitory concentration of antibiotic and the amount of antibiotic hydrolyzed. Use of sodium chloride and cloxacillin inhibition and acrylamide electrophoresis demonstrated that ampicillin resistance in Shigella is mediated by a number of different beta-lactamases. Organisms can contain more than one type of beta-lactamase.

  5. BetaShape: A new code for improved analytical calculations of beta spectra

    OpenAIRE

    Mougeot Xavier

    2017-01-01

    The new code BetaShape has been developed in order to improve the nuclear data related to beta decays. An analytical model was considered, except for the relativistic electron wave functions, for ensuring fast calculations. Output quantities are mean energies, log ft values and beta and neutrino spectra for single and multiple transitions. The uncertainties from the input parameters, read from an ENSDF file, are propagated. A database of experimental shape factors is included. A comparison ov...

  6. Expression of transforming growth factor-beta 1, -beta 2, and -beta 3 in human developing teeth: immunolocalization according to the odontogenesis phases.

    Science.gov (United States)

    Sassá Benedete, Ana Paula; Sobral, Ana Paula Veras; Lima, Dirce Mary Correia; Kamibeppu, Leonardo; Soares, Fernando Augusto; Lourenço, Silvia Vanessa

    2008-01-01

    Transforming growth factor-beta (TGF-beta) is a multifunctional growth factor that has several biological effects in vivo, including control of cell growth and differentiation, cell migration, lineage determination, motility, adhesion, apoptosis, and synthesis and degradation of extracellular matrix, and TGF-beta plays an important role in regulating tissue repair and regeneration. Our study analyzed the participation of TGF-beta 1, -beta 2, and -beta 3 in the different stages of morphogenesis and differentiation of human developing dental organ using immunohistochemistry. The maxillae and mandibles of 10 human embryos ranging from 8 to 23 weeks of gestation were employed, according to the approval of the ethical committee. Our study revealed that the TGF-beta subunits-beta 1, beta 2, and beta 3-were present in the various stages of tooth development, but the expression varied according to the differentiation stage, tissue, and TGF-beta subunit. Our results indicated that TGF-beta 1 is closely related to differentiation of enamel organ and initiation of matrix secretion, TGF-beta 2 to cellular differentiation, and TGF-beta 3 to mineral maturation matrix.

  7. ArchaeoMapper Beta Test Report

    Science.gov (United States)

    2008-06-01

    instruments. Beta Test Design Testing Environment The Geomatics II teaching lab is located in the J.B. Hunt Transport (JBHT) Services Inc. Center for...Figure 1. Geomatics II classroom in the J.B. Hunt Center for Academic Excellence Building. We did not take photos during the beta test, however, this...the test via an instructor workstation and 5 projectors (1 overhead and 4 LCD monitors in the corners of the classroom). The Geomatics II lab

  8. Cystatin C modulates cerebral beta-amyloidosis.

    Science.gov (United States)

    Kaeser, Stephan A; Herzig, Martin C; Coomaraswamy, Janaky; Kilger, Ellen; Selenica, Maj-Linda; Winkler, David T; Staufenbiel, Matthias; Levy, Efrat; Grubb, Anders; Jucker, Mathias

    2007-12-01

    The CST3 Thr25 allele of CST3, which encodes cystatin C, leads to reduced cystatin C secretion and conveys susceptibility to Alzheimer's disease. Here we show that overexpression of human cystatin C in brains of APP-transgenic mice reduces cerebral amyloid-beta deposition and that cystatin C binds amyloid-beta and inhibits its fibril formation. Our results suggest that cystatin C concentrations modulate cerebral amyloidosis risk and provide an opportunity for genetic risk assessment and therapeutic interventions.

  9. Method for treating beta-spodumene ceramics

    Science.gov (United States)

    Day, J. Paul; Hickman, David L.

    1994-09-27

    A vapor-phase method for treating a beta-spodumene ceramic article to achieve a substitution of exchangeable hydrogen ions for the lithium present in the beta-spodumene crystals, wherein a barrier between the ceramic article and the source of exchangeable hydrogen ions is maintained in order to prevent lithium contamination of the hydrogen ion source and to generate highly recoverable lithium salts, is provided.

  10. Characterization of the carrot beta-tubulin gene coding a divergent isotype, beta-2.

    Science.gov (United States)

    Okamura, S; Naito, K; Sonehara, S; Ohkawa, H; Kuramori, S; Tatsuta, M; Minamizono, M; Kataoka, T

    1997-04-01

    Four different beta-tubulin clones were isolated from carrot genomic and cDNA libraries. Their nucleotide sequences were determined 1 and their predicted amino acids were compared with each other. The predicted amino acid composition of the C-terminal region of three of them (beta-1, 3, 4) resembled one another, but that of one isotype (beta-2) was divergent. The beta-2 tubulin included two hydroxyl amino acids, serine and threonine, and consisted of a lower number of negatively charged amino acids than the others in the C-terminal region. The predicted hydrophobicity profile of the beta-2 tubulin around the residue 200 is less hydrophobic than beta-1, but it is still more hydrophobic than those of animal and fungal beta-tubulins. The beta-2 gene was transcribed in cultured cells and flowers, while the beta-1 gene was ubiquitously transcribed in cultured cells, roots, shoots and flowers. When the predicted amino acids of plant tubulin were compared with those of other organisms, substitutions from non-polar amino acids to those with hydroxyl group were conspicuous in the region corresponding to the third exon in the plant genes.

  11. Endogenous beta-cell CART regulates insulin secretion and transcription of beta-cell genes.

    Science.gov (United States)

    Shcherbina, L; Edlund, A; Esguerra, J L S; Abels, M; Zhou, Y; Ottosson-Laakso, E; Wollheim, C B; Hansson, O; Eliasson, L; Wierup, N

    2017-05-15

    Impaired beta-cell function is key to the development of type 2 diabetes. Cocaine- and amphetamine-regulated transcript (CART) is an islet peptide with insulinotropic and glucagonostatic properties. Here we studied the role of endogenous CART in beta-cell function. CART silencing in INS-1 (832/13) beta-cells reduced insulin secretion and production, ATP levels and beta-cell exocytosis. This was substantiated by reduced expression of several exocytosis genes, as well as reduced expression of genes important for insulin secretion and processing. In addition, CART silencing reduced the expression of a network of transcription factors essential for beta-cell function. Moreover, in RNAseq data from human islet donors, CARTPT expression levels correlated with insulin, exocytosis genes and key beta-cell transcription factors. Thus, endogenous beta-cell CART regulates insulin expression and secretion in INS-1 (832/13) cells, via actions on the exocytotic machinery and a network of beta-cell transcription factors. We conclude that CART is important for maintaining the beta-cell phenotype. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Complement activation by the amyloid proteins A beta peptide and beta 2-microglobulin

    DEFF Research Database (Denmark)

    Nybo, Mads; Nielsen, E H; Svehag, S E

    1999-01-01

    Complement activation (CA) has been reported to play a role in the pathogenesis of Alzheimer's disease (AD). To investigate whether CA may contribute to amyloidogenesis in general, the CA potential of different amyloid fibril proteins was tested. CA induced by A beta preparations containing soluble...... by differences observed in SDS-resistant oligomers and isoforms. Soluble Amyloid A-protein caused no significant CA. A beta and beta 2M activated complement via the classical pathway. The modifying influence by amyloid-associated molecules on A beta-induced CA was also investigated, but neither serum amyloid P...

  13. Beta adrenergic receptors in human cavernous tissue

    Energy Technology Data Exchange (ETDEWEB)

    Dhabuwala, C.B.; Ramakrishna, C.V.; Anderson, G.F.

    1985-04-01

    Beta adrenergic receptor binding was performed with /sup 125/I iodocyanopindolol on human cavernous tissue membrane fractions from normal tissue and transsexual procedures obtained postoperatively, as well as from postmortem sources. Isotherm binding studies on normal fresh tissues indicated that the receptor density was 9.1 fmoles/mg. with a KD of 23 pM. Tissue stored at room temperature for 4 to 6 hours, then at 4C in saline solution for 19 to 20 hours before freezing showed no significant changes in receptor density or affinity, and provided evidence for the stability of postmortem tissue obtained within the same time period. Beta receptor density of 2 cavernous preparations from transsexual procedures was not significantly different from normal control tissues, and showed that high concentrations of estrogen received by these patients had no effect on beta adrenergic receptor density. Displacement of /sup 125/iodocyanopindolol by 5 beta adrenergic agents demonstrated that 1-propranolol had the greatest affinity followed by ICI 118,551, zinterol, metoprolol and practolol. When the results of these displacement studies were subjected to Scatfit, non- linear regression line analysis, a single binding site was described. Based on the relative potency of the selective beta adrenergic agents it appears that these receptors were of the beta 2 subtype.

  14. [Perioperative beta-blockers. Part one: fundamentals].

    Science.gov (United States)

    Piriou, V; Aouifi, A; Lehot, J J

    2000-07-01

    To review the pharmacologic and pathophysiologic information necessary to prescribe beta-blockers (BB) in perioperative medicine. Manual retrieval and electronic research of the literature using MEDLINE (key-words: anesthesia and beta- blocker; surgery and beta-blocker). Cardioselective BB inhibit preferentially beta-1 receptors, inducing a decrease in heart rate and cardiac inotropism leading to reduction of oxygen myocardial consumption. Non-cardioselective BB inhibit also beta-2 receptors, increasing bronchial and peripheral vascular resistances and uterine contractions. However, some BB are also vasodilators (carvedilol, celiprolol, labetalol). Contraindications to BB result logically from their pharmacological effects. Treatment with BB increases membrane beta-receptor density; this explains sympathetic overactivity observed during weaning of treatment. Since the discovery of propranolol in 1964, the use of BB has been controversial in anesthesia. Formerly, the adverse effects of partial sympatholysis during anesthesia and surgery were feared. However, since 1973, experimental and clinical data have suggested a protective hemodynamic effect. Continued administration of BB up to the time of anesthesia has been encouraged except in patients with signs of intolerance such as hypotension or excessive bradycardia.

  15. The Odd Sibling : Features of beta(3)-Adrenoceptor Pharmacology

    NARCIS (Netherlands)

    Cernecka, Hana; Sand, Carsten; Michel, Martin C.

    2014-01-01

    beta(3)-Adrenoceptor agonists have recently been introduced for the treatment of overactive urinary bladder syndrome. Their target, the beta(3)-adrenoceptor, was discovered much later than beta(1)- and beta(2)-adrenoceptors and exhibits unique properties which make extrapolation of findings from the

  16. Polypeptides having beta-glucosidase activity and polynucleotides encoding same

    Energy Technology Data Exchange (ETDEWEB)

    Morant, Marc Dominique

    2014-10-14

    The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase activity, or beta-glucosidase and beta-xylosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  17. Beta-blockers in hypertension.

    Science.gov (United States)

    Ram, C Venkata S

    2010-12-15

    Beta blockers have been used in the treatment of cardiovascular conditions for decades. Despite a long history and status as a guideline-recommended treatment option for hypertension, recent meta-analyses have brought into question whether β blockers are still an appropriate therapy given outcomes data from other antihypertensive drug classes. However, β blockers are a heterogenous class of agents with diverse pharmacologic and physiologic properties. Much of the unfavorable data revealed in the recent meta-analyses were gleaned from studies involving nonvasodilating, traditional β blockers, such as atenolol. However, findings with traditional β blockers may not be extrapolated to other members of the class, particularly those agents with vasodilatory activity. Vasodilatory β blockers (i.e., carvedilol and nebivolol) reduce blood pressure in large part through reducing systemic vascular resistance rather than by decreasing cardiac output, as is observed with traditional β blockers. Vasodilating ability may also ameliorate some of the concerns associated with traditional β blockade, such as the adverse effects on metabolic and lipid parameters, including an increased risk for new-onset diabetes. Furthermore, vasodilating ability is physiologically relevant and important in treating a condition with common co-morbidities involving metabolic and lipid abnormalities such as hypertension. In patients with hypertension and diabetes or coronary artery disease, vasodilating β blockers provide effective blood pressure control with neutral or beneficial effects on important parameters for the co-morbid disease. In conclusion, it is time for a reexamination of the clinical evidence for the use of β blockers in hypertension, recognizing that there are patients for whom β blockers, particularly those with vasodilatory actions, are an appropriate treatment option. Copyright © 2010 Elsevier Inc. All rights reserved.

  18. beta-globin transcript found in induced murine erythroleukemia cells is homologous to the beta h0 and beta h1 genes.

    OpenAIRE

    Brown, B. A.; Padgett, R W; Hardies, S C; Hutchison, C A; Edgell, M H

    1982-01-01

    RNA transcripts complementary to at least one of the four beta-globin homologous genes (beta h) are found in high concentration in the murine erythroleukemic (MEL) cell line GM979 after butyric acid induction. Hybridization data indicate that the gene expressed is Hbb-beta h0 or Hbb-beta h1, or both. The level of beta h0/1 transcripts in the MEL cell is similar to the level of adult transcripts. The Hbb-beta h0/1 transcript is about 800 nucleotides in length. In addition, there is a larger be...

  19. Variação no conteúdo de beta-glucanas em cultivares brasileiros de aveia Beta-glucan content variation in brasilian oat cultivars

    Directory of Open Access Journals (Sweden)

    Roberta M. de SÁ

    2000-04-01

    Full Text Available Com o crescente interesse em alimentos funcionais e nutracêuticos, a aveia (Avena sativa L. tem se destacado, devido ao seu teor de fibras alimentares e principalmente às beta-glucanas. As (1,3(1,4-beta-D-glucanas, fibras alimentares na maioria solúveis, atuam na redução do colesterol em indivíduos com hipercolesterolemia. Existem estudos para determinar as causas de variação do teor desta fibra em aveia, porém, pouco se sabe sobre a aveia cultivada no Brasil. O objetivo deste trabalho foi verificar se existem diferenças no conteúdo de beta-glucanas entre cultivares brasileiros e se há variação na porcentagem desta fibra devido ao ano de cultivo. Os cultivares IAC7, UFRGS14, UPF16 e UPF17 (3 amostras de cada, e ainda três amostras do cultivar IAC7 para cada ano de cultivo (97 e 98, foram analisados segundo os métodos da AACC (American Association of Cereal Chemists. Os teores médios (peso seco de beta-glucanas foram 6,50% (IAC7, 4,30% (UFRGS14, 3,51% (UPF16 e 3,78% (UPF17, com erro padrão de ±0,084 e coeficiente de variação de 7,89 %. Observou-se efeito significativo dos cultivares (p=0,03 e grande variabilidade entre as amostras (p=0,0001. O cultivar IAC7 apresentou média de beta-glucanas de 5,11% em 97 e 6,50 % em 98 (erro padrão ±0,14; CV=10,53% e observou-se efeito significativo do ano de cultivo.With the increasing interest in functional foods and nutraceuticals, oats (Avena sativa L. have received special attention because of their dietary fiber contents, and specially of their beta-glucans. The mostly soluble dietary fibers (1,3(1,4-beta-D-glucans, reduce serum cholesterol in individuals with hypercholesterolemia. There are studies about the causes of variation in the contents of this fiber in oats, however, very little is known about Brazilian cultivars. The objective of this work was to verify if there were differences in the beta-glucan contents among brazilian cultivars and if there was variation in the

  20. News on $\\beta$-delayed particle emission from $^{14}$Be

    CERN Document Server

    Jeppesen, H; Borge, M J G; Cederkäll, J; Fynbo, H O U; Fedoseyev, V N; Hansper, V Y; Jonson, B; Markenroth, K; Mishin, V I; Nilsson, T; Nyman, G; Riisager, K; Tengblad, O; Wilhelmsen Rolander, K

    2002-01-01

    $\\beta$-delayed charged particles from $^{14}$Be have been measured and give an upper limit on $\\beta$-delayed $\\alpha$-particles of B($\\beta\\alpha$) < $\\,6.7\\times\\!10^{-5}$ and a tentative branching ratio on $\\beta$-delayed tritons of $7.5\\times\\!10^{-5}$ < B($\\beta$t) < $\\,3.9\\times\\!10^{-4}$. We combine the knowledge on $\\beta$-delayed particles from $^{14}$Be to deduce information on the $\\beta$-strength distribution.

  1. Importância de dosagem de beta 2 microglobulina em líquidos pleurais

    Directory of Open Access Journals (Sweden)

    Carlos Leonardo Carvalho Pessôa

    2002-05-01

    Full Text Available RESUMO: A beta 2 microglobulina é uma proteína encontrada em todas as membranas de células nucleadas, particularme nte os linfócitos.Procurou-se determinar a importância da dosagem de beta 2 microglobulina no diagnóstico diferencial da síndroma de derrame pleural; definir a importância de dosagem da beta 2 microglobulina na investigação de síndromas de derrames pleurais consequentes a tuberculose pleural. Determinar, estatisticamente, o limiar crítico discriminativo com eficiência máxima da beta 2 microglobulina pleural, em derrames pleurais tuberculosos.Realizou-se um estudo prospectivo com base na dosagem de beta 2 microglobulina, pelo método da quimioluminescência, em 42 líquidos pleurais de pacientes entre 14 e 88 anos de idade, entre Março de 1998 e Março de 1999, do Ambulatório de Pneumologia da Universidade Federal Fluminense.Trinta e nove líquidos pleurais foram avaliados e a casuística composta por 21 (54% indivíduos do sexo masculino e 18 (46% do sexo feminino. Vinte (51% casos de tuberculose pleural, 5 (13% derrames pleurais malignos, 4 (10% embolias pulmonares, 4 (10% derrames par apneumónicos, 2 (5% empiemas, 1 (3% caso de lúpus eritematoso sistémico e 3 (8% transudatos.A dosagem pleural de beta 2 microglobulina é útil como auxiliar ao diagnóstico diferencial de derrames pleurais visto apresentar-se em níveis elevados em derrames pleurais com riqueza linfocitária. A utilidade de dosagem da beta 2 microglobulina para o diagnóstico de derrames pleurais de origem tuberculosa também foi comprovada. O limiar crítico discriminativo em derrames pleurais por tuberculose foi de 3 923,0 ng/ml com eficiência de 69,23%.REV PORT PNEUMOL 2002; VIII (3: ABSTRACT: Beta 2 microglobulin is a protein found on all nucleated cell membranes, particularly in lymphocytes.The aims of this study was determine the importance of the beta 2 microglobulin dosage for differential diagnosis of the pleural effusion syndrome

  2. Cardiac beta-receptors in experimental Chagas' disease Receptores beta cardíacos na doença de Chagas experimental

    Directory of Open Access Journals (Sweden)

    Julio E. Enders

    1995-02-01

    Full Text Available Experimental Chagas' disease (45 to 90 days post-infection showed serious cardiac alterations in the contractility and in the pharmacological response to beta adrenergic receptors in normal and T. cruzi infected mice (post-acute phase. Chagasic infection did not change the beta receptors density (78.591 ± 3.125 fmol/mg protein and 73.647 ± 2.194 fmol/mg protein for controls but their affinity was significantly diminished (Kd = 7.299 ± 0.426 nM and Kd = 3.759 ± 0.212 nM for the control p Estudaram-se os receptores beta cardíacos de camundongos infectados pelo Trypanosoma cruzi na fase pós-aguda da doença de Chagas para estabelecer em que medida os mesmos contribuem a gerar respostas anômalas às catecolaminas observadas nestes miocardios. Utilizara-se 3-H/DHA para a marcação dos receptores beta cardíacos dos camundongos normais e dos infectados na fase pós-aguda (45 a 90 dias pós-infecção. O número dos sítios de fixação foi similar nos dois grupos, 78.591 ± 3.125 fmol/mg. Proteína nos chagásicos e 73.647 ± 2.194 fmol/mg. Proteína no grupo controle. Em vez disso, a afinidade verificou-se significativamente diminuida no grupo chagásico (Kd = 7.299 ± 0.426 nM respeito do controle (Kd = 3.759 ± 0.212 nM p < 0.001. Os resultados obtidos demonstram que as modificações observadas na estimulação adrenérgica do miocárdio chagásico se correlacionam com a menor afinidade dos receptores beta cardíacos e que estas alterações exerceriam uma parte determinante para as consequências funcionais que são detectadas na fase crônica.

  3. Beta2-agonists for acute bronchitis.

    Science.gov (United States)

    Becker, Lorne A; Hom, Jeffrey; Villasis-Keever, Miguel; van der Wouden, Johannes C

    2011-07-06

    There are no clearly effective treatments for the cough of acute bronchitis. Beta2-agonists are often prescribed, perhaps because clinicians suspect many patients also have reversible airflow restriction contributing to the symptoms. To determine whether beta2-agonists improve acute bronchitis symptoms in patients with no underlying pulmonary disease. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) 2011, issue 1 which contains the Acute Respiratory Infections Group's Specialised Register, MEDLINE (January 1966 to February week 1, 2011) and EMBASE (1974 to February 2011). Randomised controlled trials (RCTs) in which patients (adults, or children over two years of age) with acute bronchitis or acute cough and without known pulmonary disease were allocated to beta2-agonist versus placebo, no treatment or alternative treatment. Three review authors independently selected outcomes and extracted data while blinded to study results. Two review authors independently assessed each trial for risk of bias. We analysed trials in children and adults separately. Two trials in children (n = 109) with no evidence of airway obstruction did not find any benefits from oral beta2-agonists. Five trials in adults (n = 418) had mixed results but overall summary statistics did not reveal any significant benefits from oral (three trials) nor inhaled (two trials) beta2-agonists. There were no significant differences in daily cough scores nor in the percentage of adults still coughing after seven days (control group 73%; risk ratio (RR) 0.77, 95% confidence interval (CI) 0.54 to 1.09). in one trial, subgroups with evidence of airflow limitation had lower symptom scores if given beta2-agonists. The trials that noted quicker resolution of cough with beta2-agonists were those with a higher proportion of wheezing patients at baseline. Adults given beta2-agonists were more likely to report tremor, shakiness or nervousness (RR 7.94, 95% CI 1.17 to 53.94; number needed to

  4. Prognostic significance of TGF beta 1 and TGF beta 3 in human breast carcinoma.

    Science.gov (United States)

    Ghellal, A; Li, C; Hayes, M; Byrne, G; Bundred, N; Kumar, S

    2000-01-01

    Transforming growth factor beta s (TGF beta s) are multifunctional growth factors which show differential expression both temporally and spatially and exert pleiotropic effects during carcinogenesis. Although all three mammalian isoforms of TGF beta share considerable sequence similarity, they appear to have distinct functions in health and disease, such as embryogenesis, wound healing and tumourigenesis. Much of our knowledge about the relationship between TGF beta s and breast cancer is based on publications on TGF beta 1 but the role of TGF beta 3 in the progression of breast cancer has not been well documented. In the present study, the expression of TGF beta 1 and TGF beta 3 was assessed by immunohistochemistry. Of the 153 invasive breast cancer tissues, TGF beta 1 was expressed strongly in 25 and moderately in 98 cases. The immunoreactivity of TGF beta 3 was comparable with TGF beta 1, which was expressed strongly in 21 and moderately in 104 cases. The two isoforms were coexpressed in 111 (72.5%) tumours and were absent in 16 cases (10%). Immunostaining for TGFb3 but not TGF beta 1 was inversely correlated with overall survival (p = 0.0204). When combined with lymph node involvement, TGFb3 became an even more significant prognostic factor for overall survival (p = 0.0003), i.e. patients with node metastasis and positive TGFb3 expression had a worse prognosis: the risk of death for these patients was thirteen-fold greater than those who had no node involvement. The fact that it has been reported previously that high TGF beta 3 plasma levels in patients with untreated early stage breast cancer were correlated with subsequent lymph node metastasis and it was observed in the present study too, that TGF beta 3 expression in breast tumours was an independent predictor of overall survival, led us to suggest that the simultaneous measurement of TGF beta 3 in plasma and its expression in resected tumour tissues in the same cohort of patients may prove to be an

  5. Investigation of mutagenic effects in personnel occupationally exposed to ionizing radiation in Brazil; Investigacao de efeitos mutagenicos em trabalhadores expostos a radiacao ionizante no Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Cunha Junior, Luiz Raimundo Campos da Silva e

    2015-07-01

    Ionizing radiation (IR) are present in most of the early diagnosis of a multitude of diseases, many cancers are included, and have the characteristic of a quick and accurate diagnosis, and often cheaper. The use of this type of energy but requires specific care protection, since the IR has a characteristic of altering the genetic material through mutations. The radiology area operators in hospitals are the class of workers who are exposed more directly and thus are targets of investigations that may assist in understanding the interaction of IR with the biological material, in addition to assisting these professionals in requirement radiological protection We collected 73 samples of individuals working in various radiology departments in five hospitals in four different states in Brazil (Sao Paulo, Minas Gerais, Rio Grande do Sul and Para). The selection criteria for participation were: at least 18 years old and 2 years in the profession, not alcoholic or smoker, not taking drugs. For cytogenetic analysis were performed the comet test and micronucleus, and chromosome aberration study. This study was approved by ethics committee All the samples were compared to individuals of the same age and gender who have not gone through any kind of radiological examination in the last 6 months. When compared with the control, MN tests and AC showed a total damage, using the t test, the database and SPSS BioEstat. The comet assay showed a higher level of damage compared to controls (0.84 0,47). the average age was established and made relationship between gender and age of the participants, the more damage levels in females compared to males. Individuals aged over 45 years also showed a higher level of damage when compared with the age. A factor to be taken into consideration is that the population of Porto Alegre present a lower level of damage compared to other groups, and most likely this event due to the use of DR equipment Direct conversion. The Belo Horizonte and Ribeirao

  6. beta-adrenoceptor density in chronic infarcted myocardium : a subtype specific decrease of beta(1)-adrenoceptor density

    NARCIS (Netherlands)

    Anthonio, RL; Brodde, OE; van Veldhuisen, DJ; Crijns, HJGM; van Gilst, WH

    2000-01-01

    beta-adrenoceptor density is altered in different cardiac diseases. In heart failure beta-adrenoceptor density is down regulated but in acute myocardial ischemia beta-adrenoceptor density is up regulated. In hearts with myocardial infarction total beta-adrenoceptor density is decreased shortly after

  7. Expression of transforming growth factor beta (TGF beta) receptors and expression of TGF beta 1, TGF beta 2 and TGF beta 3 in human small cell lung cancer cell lines.

    OpenAIRE

    Damstrup, L; Rygaard, K; Spang-Thomsen, M.; Skovgaard Poulsen, H.

    1993-01-01

    A panel of 21 small cell lung cancer cell (SCLC) lines were examined for the presence of Transforming growth factor beta receptors (TGF beta-r) and the expression of TGF beta mRNAs. By the radioreceptor assay we found high affinity receptors to be expressed in six cell lines. scatchard analysis of the binding data demonstrated that the cells bound between 4.5 and 27.5 fmol mg-1 protein with a KD ranging from 16 to 40 pM. TGF beta 1 binding to the receptors was confirmed by cross-linking TGF b...

  8. beta* leveling with telescopic ATS squeeze (MD 2410)

    CERN Document Server

    Wenninger, Jorg; Hostettler, Michi; Pojer, Mirko; Ponce, Laurette; Tydecks, Tobias; CERN. Geneva. ATS Department

    2017-01-01

    Luminosity leveling by beta* is the baseline operational scenario of HL-LHC, and this leveling technique may be used in 2018 or during run~3 depending on the beam parameters and beta* range. During this MD beta*leveling was commissioned successfully for the first time with the telescopic squeeze over the beta* range of 40 cm to 30 cm. A novel beta* leveling controls technique based on a modification of the LSA trim was also tested during the MD.

  9. The biology of beta human papillomaviruses.

    Science.gov (United States)

    Tommasino, Massimo

    2017-03-02

    The beta genus comprises more than 50 beta human papillomavirus (HPV) types that are suspected to be involved, together with ultraviolet (UV) irradiation, in the development of non-melanoma skin cancer (NMSC), the most common form of human cancer. Two members of the genus beta, HPV5 and HPV8, were first identified in patients with a genetic disorder, epidermodysplasia verruciformis (EV), that confers high susceptibility to beta HPV infection and NMSC development. The fact that organ transplant recipients (OTRs) with an impaired immune system have an elevated risk of NMSC raised the hypothesis that beta HPV types may also be involved in skin carcinogenesis in non-EV patients. Epidemiological studies have shown that serological and viral DNA markers are weakly, but significantly, associated with history of NMSC in OTRs and the general population. Functional studies on mucosal high-risk (HR) HPV types have clearly demonstrated that the products of two early genes, E6 and E7, are the main viral oncoproteins, which are able to deregulate events closely linked to transformation, such as cell cycle progression and apoptosis. Studies on a small number of beta HPV types have shown that their E6 and E7 oncoproteins also have the ability to interfere with the regulation of key pathways/events associated with cellular transformation. However, the initial functional data indicate that the molecular mechanisms leading to cellular transformation are different from those of mucosal HR HPV types. Beta HPV types may act only at early stages of carcinogenesis, by potentiating the deleterious effects of other carcinogens, such as UV radiation. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Oligomerization and toxicity of A{beta} fusion proteins

    Energy Technology Data Exchange (ETDEWEB)

    Caine, Joanne M., E-mail: Jo.Caine@csiro.au [CSIRO Materials Science and Engineering and the Preventive Health Flagship, Parkville, Victoria (Australia); Bharadwaj, Prashant R. [CSIRO Materials Science and Engineering and the Preventive Health Flagship, Parkville, Victoria (Australia); Centre for Excellence for Alzheimer' s Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Western Australia (Australia); Sankovich, Sonia E. [CSIRO Materials Science and Engineering and the Preventive Health Flagship, Parkville, Victoria (Australia); Ciccotosto, Giuseppe D. [The Department of Pathology and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Victoria 3010 (Australia); Streltsov, Victor A.; Varghese, Jose [CSIRO Materials Science and Engineering and the Preventive Health Flagship, Parkville, Victoria (Australia)

    2011-06-10

    Highlights: {yields} We expressed amyloid-{beta} (A{beta}) peptide as a soluble maltose binding protein fusion (MBP-A{beta}42 and MBP-A{beta}16). {yields} The full length A{beta} peptide fusion, MBP-A{beta}42, forms oligomeric species as determined by SDS-PAGE gels, gel filtration and DLS. {yields} The MBP-A{beta}42, but not MBP-A{beta}16 or MBP alone, is toxic to both yeast and mammalian cells as determined by toxicity assays. -- Abstract: This study has found that the Maltose binding protein A{beta}42 fusion protein (MBP-A{beta}42) forms soluble oligomers while the shorter MBP-A{beta}16 fusion and control MBP did not. MBP-A{beta}42, but neither MBP-A{beta}16 nor control MBP, was toxic in a dose-dependent manner in both yeast and primary cortical neuronal cells. This study demonstrates the potential utility of MBP-A{beta}42 as a reagent for drug screening assays in yeast and neuronal cell cultures and as a candidate for further A{beta}42 characterization.

  11. Adult murine hematopoiesis can proceed without beta1 and beta7 integrins

    DEFF Research Database (Denmark)

    Bungartz, Gerd; Stiller, Sebastian; Bauer, Martina

    2006-01-01

    The function of alpha4beta1 and alpha4beta7 integrins in hematopoiesis is controversial. While some experimental evidence suggests a crucial role for these integrins in retention and expansion of progenitor cells and lymphopoiesis, others report a less important role in hematopoiesis. Using mice...

  12. Mrp2 is essential for estradiol-17 beta(beta-D-glucuronide)-induced cholestasis in rats

    NARCIS (Netherlands)

    Huang, LY; Smit, JW; Meijer, DKF; Vore, M

    The present study evaluates the roles of the multidrug resistance-1 P-glycoprotein, Mdr1a/1b, the bile salt export pump (Bsep), and the multidrug resistance-associated protein-2 (Mrp2) in mediating cholestasis induced by estradiol-17 beta(beta-D-glucuronide) (E(2)17G). Administration of [H-3]E(2)17G

  13. Preparation and characterization of lyophilized antisera against 17beta-estradiol and 17beta-testosterone

    NARCIS (Netherlands)

    van den Berg RH; Jansen EHJM; Enkelaar-Willemsen C; Roos T; Zoontjes PW; Zomer G; Stekelenburg P; van de Siepkamp JJ; Stephany RW

    1985-01-01

    Nieuwe antisera tegen 17beta-estradiol en 17beta-testosteron zijn opgewekt in konijnen door immunisatie met de overeenkomstige 17HS-BSA conjugaten. De antisera zijn in geschikte hoeveelheden geampulleerd, drooggevroren en opnieuw gekarakteriseerd. De specificiteit voor de groep estrogenen

  14. Production of beta-xylanase and beta-xylosidase by the extremely halophilic archaeon Halorhabdus utahensis

    DEFF Research Database (Denmark)

    Wainø, M.; Ingvorsen, K.

    2003-01-01

    The extremely halophilic archaeon, Halorhabdus utahensis, isolated from the Great Salt Lake, Utah, produced beta-xylanase and beta-xylosidase activities. Both enzymes were active over a broad NaCl range from near zero to 30% NaCl when tested with culture broth. A broad NaCl optimum was observed...

  15. BETA SPECTRA. I. Negatrons spectra; ESPECTROS BETA. I. Espectros simples de negatrones

    Energy Technology Data Exchange (ETDEWEB)

    Grau Malonda, A.; Garcia-Torano, E.

    1978-07-01

    Using the Fermi theory of beta decay, the beta spectra for 62 negatrons emitters have been computed introducing a correction factor for unique forbidden transitions. These spectra are plotted vs. energy, once normal i sed, and tabulated with the related Fermi functions. The average and median energies are calculated. (Author)

  16. beta-agonist-induced constitutive beta(2)-adrenergic receptor activity in bovine tracheal smooth muscle

    NARCIS (Netherlands)

    de Vries, B; Meurs, H; Roffel, AF; Elzinga, CRS; Hoiting, BH; de Vries, MML; Zaagsma, J

    2000-01-01

    1 According to the two state receptor model, the beta (2)-adrenergic receptor (beta (2)-AR) isomerizes between an inactive state and a constitutively active state, which couples to the stimulatory G-protein in the absence of agonist. In bovine tracheal smooth muscle (BTSM), we investigated the

  17. Contribution of beta-lactamase production to the resistance of mycobacteria to beta-lactam antibiotics.

    Science.gov (United States)

    Quinting, B; Reyrat, J M; Monnaie, D; Amicosante, G; Pelicic, V; Gicquel, B; Frère, J M; Galleni, M

    1997-04-14

    Mycobacterium fallax (M. fallax) is naturally sensitive to many beta-lactam antibiotics (MIC < 2 microg/ml) and devoid of beta-lactamase activity. In this paper, we show that the production of the beta-lactamase of Mycobacterium fortuitum by M. fallax significantly increased the MIC values for good substrates of the enzyme, whereas the potency of poor substrates or transient inactivators was not modified. The rates of diffusion of beta-lactams through the mycolic acid layer were low, but for all studied compounds the half-equilibration times were such that they would only marginally affect the MIC values in the absence of beta-lactamase production. These results emphasize the importance of enzymatic degradation as a major factor in the resistance of mycobacteria to penicillins.

  18. {beta}-Cyclodextrin ({beta}-CD): A new approach in bread staling

    Energy Technology Data Exchange (ETDEWEB)

    Tian, Y.Q. [The State Key Lab of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122 (China); School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122 (China); Li, Y. [Department of Plant Science, North Dakota State University, Fargo 58105, ND (United States); Jin, Z.Y., E-mail: jinlab2008@yahoo.com [The State Key Lab of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122 (China); School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122 (China); Xu, X.M., E-mail: xmxu@jiangnan.edu.cn [The State Key Lab of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122 (China); School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122 (China); Wang, J.P.; Jiao, A.Q.; Yu, B. [The State Key Lab of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122 (China); School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122 (China); Talba, T. [School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi 214122 (China)

    2009-05-20

    In this study, the impact of the addition of {beta}-cyclodextrin ({beta}-CD) on bread staling was investigated by texture profile analysis (TPA), X-ray diffraction (XRD), and differential scanning calorimeter (DSC). Results showed that the retardation effect of {beta}-CD on bread staling was found to be significant as less changes of hardness, cohesiveness and springiness were observed during the storage. The addition of {beta}-CD also significantly decreased recrystallization rate k, and increased Avrami exponent n, indicating that the nucleation type was transformed. Investigated by X-ray diffraction, changes of crystalline patterns occurring in crust and crumb were retarded by the development of A + V and B + V intermediate patterns for stored crust and stored crumb, respectively. This retardation was attributed to the amylose-lipid-{beta}-CD complex formation observed and analyzed by DSC technique, resulting in nucleation type transformation and lowering the rate of bread staling.

  19. Herramienta para hacer cuestionarios para Moodle

    OpenAIRE

    Muñoz Garcia, jesus

    2010-01-01

    Herramienta de creación de cuestionarios remotos de cuestiones SQL para Moodle. Permite también, el Aprendizaje colaborativo, para que los estudiantes puedan hacer cuestionarios de forma conjunta y desarrollar habilidades de trabajo en equipo. / Tool for Moodle to create remote quiz with SQL question. It also allows collaborative learning, so students can do together remote quiz and develop teamwork and social skills.

  20. Beta-galactosidase of Propionibacterium shermanii.

    Science.gov (United States)

    Hartley, J C; Vedamuthu, E R

    1975-01-01

    Ten strains of Propionibacterium shermanii were tested for beta-galactosidase (beta-gal) activity. Of these ten strains, five yielded enhanced enzyme activity when cell suspensions were treated with toluene-acetone; on solvent treatment, the remaining five lost a considerable portion of the activity found in whole-cell suspensions. By using a strain yielding decreased activity upon solvent treatment, explanations for the loss in activity were sought through assays for possible alternative beta-galactoside utilization mechanisms. When this strain was assayed for beta-D-phosphogalactoside galactohydrolase by using orthonitrophenyl-beta-D-galactopyranoside-6-P04 as a substrate, the activity was wither lower or indiffernt as compared with beta-gal activity determined simultaneously. Cell suspensions of P. shermanii 7 and 22 (strains chosen for further work) grown separately on the individual substrates (lactose, glucose, galactose, and sodium lactate) did not show significant differences in beta-gal activity. Optimal temperature for beta-gal activity in untreated and toluene-acetone-treated cell suspensions of strain 7 was 52 C. With strain 22, of the temperatures tested, maximal activity in untreated cell suspensions was noted at 58 C and with solvent-treated cells at 32 C. In the cell-free extract (CFE) system, both strains exhibited maximal activity at 52 C. Optimal pH for untreated and solvent-treated cell suspensions of both strains was around 7.5. In the P. shermanii 22 CFE system, maximal activity occurred at pH 7.0; pH had very little effect on enzyme activity in P. shermanii 7 CFE. Sodium or potassium phosphate buffers in the assay system yielded the best activity. In the CFE system of these two strains, Mn2+ was definitely stimulatory, but in untreated and solvent-treated cell systems of these strains presence or absence of Mn2+ in the assay system had variable effects on enzyme activity. Maximal beta-gal activity was noted in P. shermanii 7 cells harvested

  1. Beta secretase activity in peripheral nerve regeneration

    Directory of Open Access Journals (Sweden)

    Carolyn Tallon

    2017-01-01

    Full Text Available While the peripheral nervous system has the capacity to regenerate following a nerve injury, it is often at a slow rate and results in unsatisfactory recovery, leaving patients with reduced function. Many regeneration associated genes have been identified over the years, which may shed some insight into how we can manipulate this intrinsic regenerative ability to enhance repair following peripheral nerve injuries. Our lab has identified the membrane bound protease beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1, or beta secretase, as a potential negative regulator of peripheral nerve regeneration. When beta secretase activity levels are abolished via a null mutation in mice, peripheral regeneration is enhanced following a sciatic nerve crush injury. Conversely, when activity levels are greatly increased by overexpressing beta secretase in mice, nerve regeneration and functional recovery are impaired after a sciatic nerve crush injury. In addition to our work, many substrates of beta secretase have been found to be involved in regulating neurite outgrowth and some have even been identified as regeneration associated genes. In this review, we set out to discuss BACE1 and its substrates with respect to axonal regeneration and speculate on the possibility of utilizing BACE1 inhibitors to enhance regeneration following acute nerve injury and potential uses in peripheral neuropathies.

  2. COMPARISON OF THE HEMOCYANIN BETA-BARREL WITH OTHER GREEK KEY BETA-BARRELS - POSSIBLE IMPORTANCE OF THE BETA-ZIPPER IN PROTEIN-STRUCTURE AND FOLDING

    NARCIS (Netherlands)

    HAZES, B; HOL, WGJ

    The Greek key beta-barrel topology is a folding motif observed in many proteins of widespread evolutionary origin. The arthropodan hemocyanins also have such a Greek key beta-barrel, which forms the core of the third domain of this protein. The hemocyanin beta-barrel was found to be structurally

  3. Radiation-induced defects in quantum-size structures of A3B5 semiconductors =

    Science.gov (United States)

    Cavaco, Ana Margarida Rocha de Oliveira

    As estruturas quanticas de semicondutores, nomeadamente baseadas em GaAs, tem tido nos ultimos vinte anos um claro desenvolvimento. Este desenvolvimento deve-se principalmente ao potencial tecnologico que estas estruturas apresentam. As aplicacoes espaciais, em ambientes agressivos do ponto de vista do nivel de radiacao a que os dispositivos estao sujeitos, motivaram todo o desenrolar de estudos na area dos defeitos induzidos pela radiacao. As propriedades dos semicondutores e dos dispositivos de semicondutores sao altamente influenciadas pela presenca de defeitos estruturais, em particular os induzidos pela radiacao. As propriedades dos defeitos, os processos de criacao e transformacao de defeitos devem ser fortemente alterados quando se efectua a transicao entre o semicondutor volumico e as heteroestruturas de baixa dimensao. Este trabalho teve como principal objectivo o estudo de defeitos induzidos pela radiacao em estruturas quanticas baseadas em GaAs e InAs. Foram avaliadas as alteracoes introduzidas pelos defeitos em estruturas de pocos quanticos e de pontos quanticos irradiadas com electroes e com protoes. A utilizacao de varias tecnicas de espectroscopia optica, fotoluminescencia, excitacao de fotoluminescencia e fotoluminescencia resolvida no tempo, permitiu caracterizar as diferentes estruturas antes e apos a irradiacao. Foi inequivocamente constatada uma maior resistencia a radiacao dos pontos quanticos quando comparados com os pocos quanticos e os materiais volumicos. Esta resistencia deve-se principalmente a uma maior localizacao da funcao de onda dos portadores com o aumento do confinamento dos mesmos. Outra razao provavel e a expulsao dos defeitos dos pontos quanticos para a matriz. No entanto, a existencia de defeitos na vizinhanca dos pontos quanticos promove a fuga dos portadores dos niveis excitados, cujas funcoes de onda sao menos localizadas, provocando um aumento da recombinacao naoradiativa e, consequentemente, uma diminuicao da intensidade

  4. 6beta,19-Bridged androstenedione analogs as aromatase inhibitors.

    Science.gov (United States)

    Komatsu, Sachiko; Yaguchi, Ayaka; Yamashita, Kouwa; Nagaoka, Masao; Numazawa, Mitsuteru

    2009-11-01

    Inhibition of aromatase is an efficient approach for the prevention and treatment of breast cancer. New 6beta,19-bridged steroid analogs of androstenedione, 6beta,19-epithio- and 6beta,19-methano compounds 11 and 17, were synthesized starting from 19-hydroxyandrostenedione (6) and 19-formylandrost-5-ene-3beta,17beta-yl diacetate (12), respectively, as aromatase inhibitors. All of the compounds including known steroids 6beta,19-epoxyandrostenedione (4) and 6beta,19-cycloandrostenedione (5) tested were weak to poor competitive inhibitors of aromatase and, among them, 6beta,19-epoxy steroid 4 provided only moderate inhibition (K(i): 2.2 microM). These results show that the 6beta,19-bridged groups of the inhibitors interfere with binding in active site of aromatase.

  5. Desarrollo de panuveítis por tuberculosis en paciente con esclerosis múltiple tratado con interferón beta

    Directory of Open Access Journals (Sweden)

    Lucía Echevarría Lucas

    2016-09-01

    Los linfocitos CD4+ T, leucocitos, macrófagos y granulocitos, con la producción de sus mediadores interferón gamma, IL-12 o TNF-α son fundamentales para controlar al Mycobacterium tuberculosis. Por ello, antes de introducir Interferón beta 1b, convendría realizar técnicas de screening, como la prueba de Mantoux o el interferon gamma release assay–(quantiferon-TB para detectar posibles tuberculosis latentes potencialmente activables.

  6. Neutrinoless double beta decay from lattice QCD

    Science.gov (United States)

    Nicholson, Amy; Cheng, Chia; Berkowitz, Evan; Rinaldi, Enrico; Walker-Loud, Andre; Vranas, Pavlos; Kurth, Thorsten; Clark, M. A.; Garron, Nicolas; Tiburzi, Brian; Monge-Camacho, Henry; Brantley, David; Joo, Balint; Callat Collaboration

    2017-09-01

    Lepton number-violating neutrinoless double beta decay is a natural consequence of Majorana neutrinos and many BSM theories, and, if observed, could potentially explain the observed matter/anti-matter asymmetry in the universe. Several experimental searches for these processes using nuclear sources are planned and/or underway worldwide, and understanding quantitatively how neutrinoless double beta decay would manifest in nuclear environments is key for interpreting any observed signals. While long-range, light neutrino exchange is the most common mechanism studied, short-range interactions involving heavy mediator exchange may also contribute. In this talk I will give an overview of the microscopic observables relevant for experimental searches for neutrinoless double beta decay which may be calculated directly from QCD using lattice methods, and present results for short-range matrix elements contributing to pion exchange diagrams between nucleons.

  7. Pulmonary safety of ophthalmic beta-blockers

    DEFF Research Database (Denmark)

    Kristensen, Mathias L.; Simonsen, Jan Henrik; Torp-Pedersen, Christian

    2018-01-01

    PURPOSE: Ophthalmic beta-blockers, used in the treatment of increased intraocular pressure, are known to cause pulmonary adverse effects. Few, if any, studies have quantified the extent of the problem in a real-life population. In this nationwide study, we assess the pulmonary safety of patients...... initiating treatment with ophthalmic beta-blockers. METHODS: Using the Danish Nationwide Registries from 1995 to 2012, we identified all individuals aged 20-90 years who initiated monotherapy with an intraocular pressure-lowering drug, with or without concomitant obstructive pulmonary disease. Risks of (i...... concomitant obstructive pulmonary disease (n = 86 568) were as follows: 1.47 for beta-blockers (95% confidence interval (CI): 1.35-1.61; p

  8. BETASCAN: probable beta-amyloids identified by pairwise probabilistic analysis.

    Directory of Open Access Journals (Sweden)

    Allen W Bryan

    2009-03-01

    Full Text Available Amyloids and prion proteins are clinically and biologically important beta-structures, whose supersecondary structures are difficult to determine by standard experimental or computational means. In addition, significant conformational heterogeneity is known or suspected to exist in many amyloid fibrils. Recent work has indicated the utility of pairwise probabilistic statistics in beta-structure prediction. We develop here a new strategy for beta-structure prediction, emphasizing the determination of beta-strands and pairs of beta-strands as fundamental units of beta-structure. Our program, BETASCAN, calculates likelihood scores for potential beta-strands and strand-pairs based on correlations observed in parallel beta-sheets. The program then determines the strands and pairs with the greatest local likelihood for all of the sequence's potential beta-structures. BETASCAN suggests multiple alternate folding patterns and assigns relative a priori probabilities based solely on amino acid sequence, probability tables, and pre-chosen parameters. The algorithm compares favorably with the results of previous algorithms (BETAPRO, PASTA, SALSA, TANGO, and Zyggregator in beta-structure prediction and amyloid propensity prediction. Accurate prediction is demonstrated for experimentally determined amyloid beta-structures, for a set of known beta-aggregates, and for the parallel beta-strands of beta-helices, amyloid-like globular proteins. BETASCAN is able both to detect beta-strands with higher sensitivity and to detect the edges of beta-strands in a richly beta-like sequence. For two proteins (Abeta and Het-s, there exist multiple sets of experimental data implying contradictory structures; BETASCAN is able to detect each competing structure as a potential structure variant. The ability to correlate multiple alternate beta-structures to experiment opens the possibility of computational investigation of prion strains and structural heterogeneity of amyloid

  9. Hyperfine characterization of {beta}-zirconium tetrafluoride

    Energy Technology Data Exchange (ETDEWEB)

    Rivas, P.C.; Martinez, J.A.; Rodriguez, A.M.; Lopez Garcia, A.R. [Universidad Nacional de La Plata, Departamento de Fisica, Facultad de Ciencias Exactas (Argentina); Dejneka, M. [Rutgers University, Center for Ceramic Research (United States)

    1997-10-15

    The evolution of the hyperfine quadrupole interaction in {beta}-ZrF{sub 4} at Zr sites, is measured between 273 and 740 K via the Perturbed Angular Correlations technique. Two different quadrupole interactions, in a ratio 1:2 of relative fractions, are determined. It is observed that the compound remains stable all over the thermal range. Moisture exposure at room temperature seems not to affect the hyperfine interaction suggesting that {beta}-ZrF{sub 4} is less sensitive to air water than other varieties of zirconium fluoride.

  10. Method of producing .beta.-spodumene bodies

    Science.gov (United States)

    Chyung, Kenneth; Day, J. Paul; Holleran, Louis M.; Olszewski, Anthony R.

    1999-01-01

    Beta-spodumene bodies and method of preparing the bodies that involves providing a uniform plastic batch of inorganic raw materials, organic binder, and vehicle, wherein the inorganic raw materials are composed of, in percent by weight, about 75% to 95% minerals, and about 5% to 25% glass. The batch is formed into a green body that is fired to produce a body composed substantially of beta-spodumene, and having a thermal expansion coefficient of <10.times.10.sup.-7 /.degree.C.(0-800.degree. C.), and a strength of .gtoreq.4 Ksi.

  11. Method of producing {beta}-spodumene bodies

    Energy Technology Data Exchange (ETDEWEB)

    Chyung, K.; Day, J.P.; Holleran, L.M.; Olszewski, A.R.

    1999-10-05

    {beta}-spodumene bodies and method of preparing the bodies are disclosed that involves providing a uniform plastic batch of inorganic raw materials, organic binder, and vehicle, wherein the inorganic raw materials are composed of, in percent by weight, about 75% to 95% minerals, and about 5% to 25% glass. The batch is formed into a green body that is fired to produce a body composed substantially of {beta}-spodumene, and having a thermal expansion coefficient of {minus}7/C (0--800 C), and a strength of {ge}4 Ksi.

  12. Characterizing urinary hCG beta cf patterns during pregnancy

    OpenAIRE

    Nerenz, Robert D.; Yarbrough, Melanie L.; Stenman, Ulf-Hakan; Gronowski, Ann M.

    2016-01-01

    Objective: Elevated concentrations of hCG beta core fragment (hCG beta cf) are known to cause false-negative results in qualitative urine pregnancy test devices, but the pattern of urinary hCG beta cf during normal pregnancy has not been well characterized. Here, we evaluate the relationship between urine hCG, hCG beta cf, and hCG free beta subunit (hCG beta) during pregnancy. Design and methods: Banked second trimester urine specimens from 100 pregnant women were screened for high concentrat...

  13. The nematode parasite Onchocerca volvulus generates the transforming growth factor-beta (TGF-beta).

    Science.gov (United States)

    Korten, Simone; Büttner, Dietrich W; Schmetz, Christel; Hoerauf, Achim; Mand, Sabine; Brattig, Norbert

    2009-09-01

    Transforming growth factor-beta (TGF-beta) is a highly conserved cytokine that has a well-known regulatory role in immunity, but also in organ development of most animal species including helminths. Homologous tgf-b genes and mRNA have been detected in the filaria Brugia malayi. The in situ protein expression is unknown for filariae. Therefore, we examined several filariae for the expression and localization of latent (stable) TGF-beta in adult and larval stages. A specific goat anti-human latency associated protein (LAP, TGF-beta 1) antibody, purified by affinity chromatography, was used for light and electron microscopic immunohistochemistry. Adult Onchocerca volvulus, Onchocerca gibsoni, Onchocerca ochengi, Onchocerca armillata, Onchocerca fasciata, Onchocerca flexuosa, Wuchereria bancrofti, Dirofilaria sp., B. malayi, and infective larvae of W. bancrofti reacted with the antibody. Labeling of worm tissues varied between negative and all degrees of positive reactions. Latent TGF-beta was strongly expressed adjacent to the cell membranes of the hypodermis, epithelia, and muscles and adjacent to many nuclei in all organs. TGF-beta was well expressed in worms without Wolbachia endobacteria eliminated by doxycycline treatment. Pleomorphic neoplasms in O. volvulus were also labeled. We conclude that latent TGF-beta protein is expressed by filariae independently of Wolbachia, possibly regulating worm tissue homeostasis.

  14. Nuclear Matrix Elements for the $\\beta\\beta$ Decay of the $^{76}$Ge

    CERN Document Server

    Brown, B A; Horoi, M

    2015-01-01

    The nuclear matrix elements for two-neutrino double-beta (2 n$\\beta\\beta$ ) and zero-neutrino double-beta (0 n$\\beta\\beta$) decay of 76 Ge are evaluated in terms of the configuration interaction (CI), quasiparticle random phase approximation (QRPA) and interacting boson model (IBM) methods. We show that the decomposition of the matrix elements in terms of interemediate states in 74 Ge is dominated by ground state of this nucleus. We consider corrections to the CI results that arise from configurations admixtures involving orbitals out-side of the CI configuration space by using results from QRPA, many-body-perturbation theory, and the connections to related observables. The CI two-neutrino matrix element is reduced due to the inclusion of spin-orbit partners, and to many-body correlations connected with Gamow-Teller beta decay. The CI zero-neutrino matrix element for the heavy neutrino is enhanced due to particle-particle correlations that are connected with the odd-even oscillations in the nuclear masse...

  15. A New alpha5beta1 integrin-dependent survival pathway through GSK3beta activation in leukemic cells.

    Directory of Open Access Journals (Sweden)

    Fabienne De Toni-Costes

    2010-03-01

    Full Text Available Cell survival mediated by integrin engagement has been implicated in cell adhesion-mediated drug resistance. We have recently demonstrated that the activation of glycogen synthase kinase 3 beta (GSK3beta is a new pathway supporting the chemoresistance of leukemic cells adhered to fibronectin.We show here that in conditions of serum starvation, the fibronectin receptor alpha(5beta(1 integrin, but not alpha(4beta(1, induced activation of GSK3beta through Ser-9 dephosphorylation in adherent U937 cells. The GSK3beta-dependent survival pathway occurred in adherent leukemic cells from patients but not in the HL-60 and KG1 cell lines. In adhesion, activated GSK3beta was found in the cytosol/plasma membrane compartment and was co-immunoprecipitated with alpha(5 integrin, the phosphatase PP2A and the scaffolding protein RACK1. PP2A and its regulatory subunit B' regulated the Ser-9 phosphorylation of GSK3beta. In adherent leukemic cells, alpha(5beta(1 integrin but not alpha(4beta(1 upregulated the resistance to TNFalpha-induced apoptosis. Both extrinsic and intrinsic apoptotic pathways were under the control of alpha(5beta(1 and GSK3beta.Our data show that, upon serum starvation, alpha(5beta(1 integrin engagement could regulate specific pro-survival functions through the activation of GSK3beta.

  16. Fundamental and clinical studies on the measurement of. beta. /sub 2/-microglobulin using Dainabot. beta. /sub 2/-micro RIA kit

    Energy Technology Data Exchange (ETDEWEB)

    Sugimura, Hidekazu; Iino, Yuko; Sakata, Hiroyuki; Kihara, Kazuhiro; Satoh, Kunio; Demura, Hiroshi; Kawaguchi, Hiroshi; Odagiri, Reiko

    1987-06-01

    A commercial simple one-step assay system for ..beta../sub 2/-microglobulin (..beta../sub 2/-MG), Dainabot ..beta../sub 2/-MG radioimmunoassay (RIA) kit, was fundamentally examined for incubation, recovery, dilution, reproducibility, and correlation with the other assay system. The RIA kit was satisfactory enough to use it routinely. Normal upper limits for ..beta../sub 2/-MG in serum (S-..beta../sub 2/-MG) and urine (U-..beta../sub 2/-MG) were 1.92 mg/l and 460 ..mu..g/l, respectively. Decreased values of two-hr creatinine clearance were inversely correlated with increased values of serum creatinine, blood urea nitrogen, and S-..beta../sub 2/-MG. U-..beta../sub 2/-MG tended to increase with decreasing values of 15-min phenolsulfonphthalein. In the case of renal tubular acidosis, Fanconi's syndrome, Wilson's disease, hydronephrosis, and pyelonephritis, S-..beta../sub 2/-MG was normal and U-..beta../sub 2/-MG was abnormal. Since S-..beta../sub 2/-MG and U-..beta../sub 2/-MG are recognized as reflecting glomerular function and renal tubular disturbances, respectively, concurrent measurements of S-..beta../sub 2/-MG and U-..beta../sub 2/-MG may be of clinical value. (Namekawa, K.).

  17. Complementary DNA cloning of the alternatively expressed endothelial cell glycoprotein Ib beta (GPIb beta) and localization of the GPIb beta gene to chromosome 22.

    Science.gov (United States)

    Kelly, M D; Essex, D W; Shapiro, S S; Meloni, F J; Druck, T; Huebner, K; Konkle, B A

    1994-01-01

    Glycoprotein Ib beta (GPIb beta) exists in platelets disulfide-linked to glycoprotein Ib alpha (GPIb alpha), a major receptor for von Willebrand factor. Both GPIb alpha and GPIb beta are expressed in endothelial cells (EC). While the GPIb alpha mRNA and protein appear similar in platelets and EC, EC GPIb beta mRNA is larger than platelet GPIb beta and encodes a larger protein. We have cloned and sequenced EC GPIb beta cDNA and report a 2793-nucleotide sequence which contains a 411-amino acid open reading frame. The EC sequence contains all of the platelet cDNA sequence and all but three amino acids of the primary translation product. Like the genes encoding GPIb alpha, GPIX, and GPV, the GPIb beta gene appears simple in structure. Using human hamster hybrids, we have localized the GPIb beta gene to chromosome 22pter-->22q11.2. When we examined poly (A)+ RNA from several human tissues for GPIb beta mRNA expression, we found that GPIb beta mRNA was expressed in a variety of tissues but was most abundant in heart and brain, while GPIb alpha and GPIX mRNA expression was found only in lung and placenta at very low levels. The broad distribution of GPIb beta mRNA suggests that it may be playing a role different than or additional to its function in platelets. Images PMID:8200976

  18. Dopants and dielectric properties of {beta}-eucryptite and {beta}-spodumene porcelain

    Energy Technology Data Exchange (ETDEWEB)

    Abdel-Fattah, W.I. [National Research Centre, Dokki (Egypt). Ceramics Dept.; El-Amir, G.; Abdellah, R.A. [Idustrial Education Faculty, Cairo (Egypt)

    2002-07-01

    The present work was devoted to study the effect of either Cu{sup 2+} or Fe{sup 3+} or Ti{sup 4+} (0.05 mol) on the vitrification of {beta}- eucryptite (G{sub 1}), {beta}- eucryptite solid solution (G{sub 2}) and {beta} -spodumene (G{sub 3}) porcelain and consequent electric properties. Activation energy and mobility of charge carriers were calculated from changes of d.c. resistivety values with temperature and correlated with parent body compositions. The application as low temperature sensor was assessed through dielectric constant measurements. (orig.)

  19. Equipamiento para exhibiciones itinerantes

    OpenAIRE

    Montemurro, Florencia

    2012-01-01

    El trabajo consiste en el diseño de un equipamiento para muestras itinerantes para el Museo de Ciencias Naturales de la ciudad de La Plata. Para su desarrollo se tomó como concepto la desestructuración de la imagen del Museo. El objetivo era generar una imagen más actual y renovada de este establecimiento como estrategia para atraer diferentes tipos de visitantes. (Párrafo extraído del texto a modo de resumen) Facultad de Bellas Artes

  20. Repito para recordar : Recuerdo para religar

    OpenAIRE

    Juárez, Horacio Eduardo

    2015-01-01

    Tanto la repitencia y el abandono escolar continúan generando importantes desafíos para el sistema educativo, a pesar de los grandes esfuerzos realizados en los últimos años en la Argentina para mejorar la inclusión y la calidad educativa. El presente proyecto de investigación de tipo cualitativo, se propone explorar a través de conceptos psicológicos como la transferencia, la influencia del profesor de educación física en el rendimiento académico del alumno de escuela secundaria. El vínculo ...

  1. Nueva Sede para la Academia

    Directory of Open Access Journals (Sweden)

    Mario Camacho Pinto

    1994-06-01

    , confortablemente amoblada.

    6. Auditorio funcional de moderno corte inclinado, semicircular, con 106 sillas plegables, sufragadas por cuotas voluntarias de académicos, en el plan ”Venta de Sillas”, más la última dotación audiovisual consistente en:

    a Videograbadora de doble cassette.

    b Proyector de diapositivas con dos lentes Zoom, Dispositivo Beta y VHS.

    c Telón importado automático y panorámico.

    d Doble pantalla de TV. con soportes móviles incrustados.

    e Mesa directiva con sus sillas compañeras y podio para conferenciante.

    f Micrófono inalámbrico con filtro para ruidos y linterna láser.

    7. Entapetado total de los pisos en varios colores.
    8. Oficinas amplias con Presidencia señorial. secretarías, auxiliares y fotocopiadora.

    9. Biblioteca centralizada en tres salas con estantería en madera a todo lo alto y ancho de sus muros, lista para sistematización, en proceso de instalación de terminal de computador y banco de datos.

    10. Hemeroteca con adquisición de mueble especial rodante y servicio de bibliografía de actualización, suministrado por cortesía de Iladiba y su Director Académico Jorge Maldonado.

    11. Se competó la colección de la Pinacoteca de Académicos Fundadores, ex presidentes, Académicos dignos de nuestra admiración y respeto reorganizada con imagenología pintada a. mano.

    12. Alojamiento amplio y cómodo para servidores.

    13. Refacción total de la antigua sede.

    14. Su arrendamiento para renta de la Academia ya contratado.

    15. Organización interior de funcionamiento de la nueva sede, con autorización de alquilar sus instalaciones para eventos de carácter científico.

    16. Innumerables gestiones para conseguir benefactores cuyo número en la actualidad llega a 22.

    17. Realización de eventos científicos, dentro y fuera del recinto de la Academia, académicos unos, otros para beneficio económico.

    18. Gestiones ante el Gobierno

  2. Automatic TLI recognition system beta prototype testing

    Energy Technology Data Exchange (ETDEWEB)

    Lassahn, G.D.

    1996-06-01

    This report describes the beta prototype automatic target recognition system ATR3, and some performance tests done with this system. This is a fully operational system, with a high computational speed. It is useful for findings any kind of target in digitized image data, and as a general purpose image analysis tool.

  3. Graphene oxide strongly inhibits amyloid beta fibrillation

    NARCIS (Netherlands)

    Mahmoudi, Morteza; Akhavan, Omid; Ghavami, Mahdi; Rezaee, Farhad; Ghiasi, Seyyed Mohammad Amin

    2012-01-01

    Since amyloid beta fibrillation (AbF) plays an important role in the development of neurodegenerative diseases, we investigated the effect of graphene oxide (GO) and their protein-coated surfaces on the kinetics of Ab fibrillation in the aqueous solution. We showed that GO and their protein-covered

  4. Beta-2-agonists of third generation.

    Science.gov (United States)

    Palma-Carlos, A G; Palma-Carlos, G S

    1986-04-01

    Beta-adrenergic agents have been used for a long time in the treatment of asthma. For the purpose of bronchodilation the better results would be attained with the increase in Beta-2-selectivity. From the newer Beta-agonists the mot currently used are TERBUTALINE, FENOTEROL, SALBUTAMOL, CLEMBUTEROL, TOLBUTEROL, CARBUTEROL, PROCATEROL, RIMITEROL and REPROTEROL, this last combining in its molecule the structure of a beta-agonist with a Xanthine group. These agents could be used in different ways, by mouth, injection and inhalation (with a exception of Clembuterol which is effective only by oral route). The authors have, some years ago, comparatively studied the bronchodilating effect of Salbutamol and Fenoterol including 18 patients. The main increase of PFR was slightly higher after FENOTEROL but this difference was not significant. The authors have studied REPROTEROL by inhalation and oral routes in 11 asthmatic patients. After inhalation of 400 mcg of REPROTEROL the bronchodilator effect was comparable to others inhaled bronchodilators. However they could not confirm that REPROTEROL acts also as a Xanthine and only traces of Theophylline have been detected in blood of subjects taking it. These data seem to indicate that REPROTEROL do not release Theophylline in the body or only release a Xanthine like compound not detected by "EMIT" of high pressure liquid chromatography.

  5. SERUM BETA HUMAN CHORIONIC GONADOTROPHIN IN HUMAN ...

    African Journals Online (AJOL)

    Objectives To determine whether raised levels of serum Beta -HCG) are associated with higher grade and Human Chorionic Gonadotrophin ( -HCG in higher category tumors and whether in patients with raised levels of -HCG their sera the rise (above normal range) and the fall (to normal) in levels would correspond with ...

  6. Topical beta-Blockers and Mortality

    NARCIS (Netherlands)

    Muskens, Rogier P. H. M.; Wolfs, Roger C. W.; Wittenian, Jacqueline C. M.; Hofman, Albert; de Jong, Paulus T. V. M.; Stricker, Bruno H. C.; Jansonius, Nomdo M.

    2008-01-01

    Purpose: To study the associations between long-term and short-term use of topical beta-blockers and mortality. Design: Prospective population-based cohort study. Participants: To examine long-term effects, 3842 participants aged 55 years and older were recruited. To examine short-term effects, 484

  7. Split Beta-Lactamase Complementation Assay

    Indian Academy of Sciences (India)

    IAS Admin

    one Bla fragment) against a library of DNA molecules (fused to another Bla fragment) encoding other cellular proteins. A Word of Caution: Controls are Important! Although PCAs like split TEM-1 beta-lactamase can be very informative about the protein–protein interaction patterns, but these could be equally erroneous if ...

  8. Reactor antineutrino spectra and forbidden beta decays

    Science.gov (United States)

    Štefánik, Dušan; Dvornický, Rastislav; Šimkovic, Fedor

    2017-10-01

    The exact relativistic shape factors, associated with the nuclear matrix elements governing the first forbidden beta decays, are presented. It is expected that their consideration can allow a more accurate theoretical description of antineutrino fluxes from the power reactor. A qualitative analysis of the uncertainty of reactor antineutrino flux from 235U within the electron spectrum conversion method is performed.

  9. beta-decay of O-13

    NARCIS (Netherlands)

    Knudsen, HH; Fynbo, HOU; Borge, MJG; Boutami, R; Dendooven, P; Diget, CA; Eronen, T; Fox, S; Fraile, LM; Fulton, B; Huikary, J; Jeppesen, HB; Jokinen, AS; Jonson, B; Kankainen, A; Moore, [No Value; Nieminen, A; Nyman, G; Penttila, H; Riisager, K; Rinta-Antila, S; Tengblad, O; Wang, Y; Wilhelmsen, K; Aysto, J

    2005-01-01

    The beta decay of O-13 has been studied at the IGISOL facility of the Jyvaskyla accelerator centre (Finland). By developing a low-energy isotope-separated beam of O-13 and using a modern segmented charged-particle detector array an improved measurement of the delayed proton spectrum was possible.

  10. .beta.-glucosidase 5 (BGL5) compositions

    Science.gov (United States)

    Dunn-Coleman, Nigel; Goedegebuur, Frits; Ward, Michael; Yao, Jian

    2010-06-01

    The present invention provides a novel .beta.-glucosidase nucleic acid sequence, designated bgl5, and the corresponding BGL5 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL5, recombinant BGL5 proteins and methods for producing the same.

  11. Prevalence of Extended Spectrum Beta Lactamases (ESBL ...

    African Journals Online (AJOL)

    Resistance to broad spectrum β lactams, mediated by extended spectrum beta lactamase (ESβL) is an increasing problem worldwide. Production of these enzymes in clinical infections can result in treatment failure if one of the second or third generation cephalosporins is used. This study investigates the incidence of ESBL ...

  12. Preparation and Characterization of Nanoliposomal Beta ...

    African Journals Online (AJOL)

    natural plant products such as curcumin [15], epigallocatechin-3-gallate [16], celastrol [17], tea polyphenol [18], berberine [19] and gossypol [20] in various cancer cell lines. Therefore, beta- cryptoxanthin and other effective plant-derived agents, in particular in loaded form, could be considered as a promising strategy for.

  13. Short Communication: Production of extended spectrum beta ...

    African Journals Online (AJOL)

    Multidrug resistant strains of Klebsiella pneumoniae and Escherichia coli constitute a problem in many hospitals. The antibiotic susceptibility profile and the Production of Extended Spetrum Beta-Lactamase (ESBL) of the strains of Klebsiella pneumoniae and Escherichia coli were assessed by the Kirby-Bauer technique and ...

  14. Association behavior of native beta-lactoglobulin

    DEFF Research Database (Denmark)

    Verheul, M.; Pedersen, J.S.; Roefs, S.P.F.M.

    1999-01-01

    The association behavior of beta-lactoglobulin has been studied by small-angle neutron scattering as a function of protein concentration, temperature, pH, and NaCl concentration of the solution. By indirect Fourier transformation of the spectra, pair-distance distribution functions for the variou...

  15. INGENIERIA DE PROTEINAS DE UAN BETA-1,3-ENDOGLUCANASA LITICA CAPAZ DE PERMEABILIZAR CELULAS DE LEVADURA

    OpenAIRE

    OLIVERA NAPPA; ALVARO MARIA

    2005-01-01

    La endo-Beta ,3-glucanasa Bgl ll de C. cellulans (O. xanthineolytica) se presenta como una buena alternativa para ser utilizada como enzima modelo de un grupo amplio de glicosil hidrolasas, por lo que los estudios efectuados sobre ella pueden ser fácilmente extrapolables a otras enzimas, dentro de las cuales pueden contarse enzimas de claro interés industrial. Muchos procesos biotecnológicos en los que estas enzimas pueden ser de utilidad operan bajo condiciones de pH no óptimas para su acti...

  16. Neutrino masses and neutrinoless double-beta decay

    Energy Technology Data Exchange (ETDEWEB)

    Pavan, M. [Dipartimento di Fisica dell' Universita di Milano, Bicocca and sezioneINFN di Milano Bicocca (Italy)

    2008-12-15

    The potentials of Double Beta Decay experiments in the field of neutrino study are here discussed. Sensitivity and results are compared with the information coming from oscillation, cosmology and beta decay measurements. (Author)

  17. Rheumatoid factors from patients with rheumatoid arthritis react with Des-Lys58-beta 2m, modified beta 2-microglobulin

    DEFF Research Database (Denmark)

    Williams, R C; Nissen, Mogens Holst; Malone, C C

    1993-01-01

    Ten polyclonal IgM rheumatoid factor (RF) preparations, affinity-purified from IgG columns, from patients with rheumatoid arthritis were studied for their ELISA reactivity with native beta 2m in parallel with Lys58-cleaved beta 2m and Des-Lys58-beta 2m, the latter representing cleavage products...... of the native molecule present in some pathologic human sera. Most RF showed positive reactions with the native form of beta 2m but reduced reactivity for the cleaved forms of beta 2m. Reactions between cleaved beta 2m and RF, in solution, were demonstrated by inhibition of RF binding to native beta 2m...... by preincubation with a range of concentrations of Des-Lys58-beta 2m. By contrast, eight of nine murine MoAbs to human beta 2m showed approximately equivalent binding to native beta 2m, Lys58-cleaved beta 2m, and Des-Lys58-beta 2m. Reactions between individual human RF and the altered forms of beta 2m (Lys58...

  18. BetaShape: A new code for improved analytical calculations of beta spectra

    Science.gov (United States)

    Mougeot, Xavier

    2017-09-01

    The new code BetaShape has been developed in order to improve the nuclear data related to beta decays. An analytical model was considered, except for the relativistic electron wave functions, for ensuring fast calculations. Output quantities are mean energies, log ft values and beta and neutrino spectra for single and multiple transitions. The uncertainties from the input parameters, read from an ENSDF file, are propagated. A database of experimental shape factors is included. A comparison over the entire ENSDF database with the standard code currently used in nuclear data evaluations shows consistent results for the vast majority of the transitions and highlights the improvements that can be expected with the use of BetaShape.

  19. Conformation, molecular packing and field effect mobility of regioregular beta,beta'-dihexylsexithiophiophene

    DEFF Research Database (Denmark)

    Kiriy, N.; Kiriy, A.; Bocharova, V.

    2004-01-01

    by the pulse-radiolysis time-resolved microwave conductivity (PR-TRMC) technique was found to be Sigmamu(min) = 3.9 x 10(-3) cm(2) V-1 s(-1), which is comparable with the PR-TRMC mobility found for alpha,omega-DH6T. The field-effect mobility (FEM) of beta,beta'-DH6T was found to be on the order of 10(-5) cm(2......) V-1 s(-1), which is considerably less than the FEM of alpha,omega-DH6T. To understand the reason for such poor macroscopic electrical properties, the conformation and the molecular packing of beta,beta'-DH6T were systematically studied by means of UV-vis spectroscopy, scanning electron microscopy...

  20. BetaShape: A new code for improved analytical calculations of beta spectra

    Directory of Open Access Journals (Sweden)

    Mougeot Xavier

    2017-01-01

    Full Text Available The new code BetaShape has been developed in order to improve the nuclear data related to beta decays. An analytical model was considered, except for the relativistic electron wave functions, for ensuring fast calculations. Output quantities are mean energies, log ft values and beta and neutrino spectra for single and multiple transitions. The uncertainties from the input parameters, read from an ENSDF file, are propagated. A database of experimental shape factors is included. A comparison over the entire ENSDF database with the standard code currently used in nuclear data evaluations shows consistent results for the vast majority of the transitions and highlights the improvements that can be expected with the use of BetaShape.

  1. Universality in Chiral Random Matrix Theory at {beta} = 1 and {beta} = 4

    Energy Technology Data Exchange (ETDEWEB)

    Sener, M.K.; Verbaarschot, J.J. [Department of Physics and Astronomy, SUNY, Stony Brook, New York 11794 (United States)

    1998-07-01

    In this paper the kernel for the spectral correlation functions of invariant chiral random matrix ensembles with real ({beta}=1 ) and quaternion real ({beta}=4 ) matrix elements is expressed in terms of the kernel of the corresponding complex Hermitian random matrix ensembles ({beta}=2 ). Such identities are exact in case of a Gaussian probability distribution and, under certain smoothness assumptions, they are shown to be valid asymptotically for an arbitrary finite polynomial potential. They are proved by means of a construction proposed by Brezin and Neuberger. Universal behavior of the eigenvalues close to zero for all three chiral ensembles then follows from microscopic universality for {beta}=2 as shown by Akemann, Damgaard, Magnea, and Nishigaki. {copyright} {ital 1998} {ital The American Physical Society}

  2. Structures and functions of calcium channel beta subunits.

    Science.gov (United States)

    Birnbaumer, L; Qin, N; Olcese, R; Tareilus, E; Platano, D; Costantin, J; Stefani, E

    1998-08-01

    Calcium channel beta subunits have profound effects on how alpha1 subunits perform. In this article we summarize our present knowledge of the primary structures of beta subunits as deduced from cDNAs and illustrate their different properties. Upon co-expression with alpha1 subunits, the effects of beta subunits vary somewhat between L-type and non-L-type channels mostly because the two types of channels have different responses to voltage which are affected by beta subunits, such as long-lasting prepulse facilitation of alpha1C (absent in alpha1E) and inhibition by G protein betagamma dimer of alpha1E, absent in alpha1C. One beta subunit, a brain beta2a splice variant that is palmitoylated, has several effects not seen with any of the others, and these are due to palmitoylation. We also illustrate the finding that functional expression of alpha1 in oocytes requires a beta subunit even if the final channel shows no evidence for its presence. We propose two structural models for Ca2+ channels to account for "alpha1 alone" channels seen in cells with limited beta subunit expression. In one model, beta dissociates from the mature alpha1 after proper folding and membrane insertion. Regulated channels seen upon co-expression of high levels of beta would then have subunit composition alpha1beta. In the other model, the "chaperoning" beta remains associated with the mature channel and "alpha1 alone" channels would in fact be alpha1beta channels. Upon co-expression of high levels of beta the regulated channels would have composition [alpha1beta]beta.

  3. Tertiary and quaternary structure of lung beta-adrenergic receptors

    Energy Technology Data Exchange (ETDEWEB)

    Fraser, C.M.; Venter, J.C.

    1986-05-01

    Guinea pig lung beta/sub 2/-adrenergic receptors (..beta..AR)specifically labeled with a photoaffinity probe, (/sup 125/I)-iodocyanopindolol diazirine, have a molecular mass (M/sub r/) of 68 kDa on SDS-PAGE. When labeled ..beta..AR are subjected to limited proteolysis in the membrane, water soluble fragments of M/sub r/ = 43, 30, 27 and 25 kDA are produced. These data indicate that over 50 percent of the ..beta..AR protrudes from the membrane into the extracellular space. Purification of ..beta..AR by sequential chromatography on alprenolol-Sepharose, DEAE-Sepharose and size exclusion HPLC indicates that the ..beta..AR is extracted from membranes as an oligomeric complex. Two peaks of ..beta..AR that correspond to apparent molecular weights of 370,000 (t=36 min) and 170,000 (t=43 min) elute from HPLC columns. Radioiodination of these fractions and analysis by SDS-PAGE indicates that peak 36 contains ..beta..AR (68 kDa) purified to homogeneity; peak 43 contains ..beta..AR plus other proteins. If ..beta..AR from DEAE columns are allowed to stand at 4/sup 0/C for 7 days prior to HPLC purification, all ..beta..AR elute in peak 43. These data suggest that ..beta..AR are isolated from membranes as dissociable oligomeric complexes. Target size analysis (TSA) of intact ..beta..AR in situ supports the idea of ..beta..AR oligomers. Application of TSA to ..beta..AR indicates that the ..beta..AR has a functional molecular size of 124,000 daltons in the membrane and 270,000 daltons when solubilized with digitonin.

  4. Beta-lactam versus beta- lactam/macrolide therapy in pediatric outpatient pneumonia.

    Science.gov (United States)

    Ambroggio, Lilliam; Test, Matthew; Metlay, Joshua P; Graf, Thomas R; Blosky, Mary Ann; Macaluso, Maurizio; Shah, Samir S

    2016-05-01

    The objective was to evaluate the comparative effectiveness of beta-lactam monotherapy and beta- lactam/macrolide combination therapy in the outpatient management of children with community-acquired pneumonia (CAP). This retrospective cohort study included children, ages 1-18 years, with CAP diagnosed between January 1, 2008 and January 31, 2010 during outpatient management in the Geisinger Health System. The primary exposure was receipt of beta-lactam monotherapy or beta-lactam/macrolide combination therapy. The primary outcome was treatment failure, defined as a follow-up visit within 14 days of diagnosis resulting in a change in antibiotic therapy. Logistic regression within a propensity score- restricted cohort was used to estimate the likelihood of treatment failure. Of 717 children in the analytical cohort, 570 (79.4%) received beta-lactam monotherapy and 147 (20.1%) received combination therapy. Of those who received combination therapy 58.2% of children were under 6 years of age. Treatment failure occurred in 55 (7.7%) children, including in 8.1% of monotherapy recipients, and 6.1% of combination therapy recipients. Treatment failure rates were highest in children 6-18 years receiving monotherapy (12.9%) and lowest in children 6-18 years receiving combination therapy (4.0%). Children 6-18 years of age who received combination therapy were less likely to fail treatment than those who received beta-lactam monotherapy (propensity-adjusted odds ratio, 0.51; 95% confidence interval, 0.28, 0.95). Children 6-18 years of age who received beta- lactam/macrolide combination therapy for CAP in the outpatient setting had lower odds of treatment failure compared with those who received beta-lactam monotherapy. © 2015 Wiley Periodicals, Inc.

  5. Factor de crecimiento transformante beta-1: estructura, función y mecanismos de regulación en cáncer Transforming growth factor beta-1: structure, function and regulation mechanisms in cancer

    Directory of Open Access Journals (Sweden)

    Oscar Peralta-Zaragoza

    2001-08-01

    Full Text Available El factor de crecimiento transformante beta-1 (TGF-beta1 es sintetizado por muchas estirpes celulares como linfocitos, macrófagos y células dendríticas, y su expresión regula de manera autócrina o parácrina la diferenciación, proliferación y el estado de activación de éstas y muchas otras células. En general, el TGF-beta1 tiene propiedades pleiotrópicas en el contexto de la respuesta inmune durante el desarrollo de infecciones y procesos neoplásicos; sin embargo, los mecanismos de acción y regulación de la expresión de esta citocina aún no se comprenden del todo. En la presente revisión se describen las propiedades biológicas y los procesos moleculares que regulan la expresión del TGF-beta1, para entender los efectos de esta citocina durante la proliferación y la diferenciación celular. El conocimiento de los mecanismos moleculares de la regulación del TGF-beta1 puede representar una importante estrategia de tratamiento del cáncer. El texto completo en inglés de este artículo está disponible en: http://www.insp.mx/salud/index.htmlTransforming growth factor beta-1 (TGF-beta1 is produced by several cell lineages such as lymphocytes, macrophages, and dendritic cells, and its expression serves in both autocrine and paracrine modes to control the differentiation, proliferation, and state of activation of these and other cells. In general, TGF-beta1 has pleiotropic properties on the immune response during the development of infection diseases and cancer; however, the mechanisms of action and regulation of gene expression of this cytokine are poorly understood, In this review, the biological properties and the molecular mechanisms that regulate TGF-beta1 gene expression are described, to understand the role of this cytokine in growth and cell differentiation. The knowledge of molecular mechanisms of gene expression of TGF-beta1 may serve to develop new cancer therapies. The English version of this paper is available at: http://www.insp.mx/salud/index.html

  6. The BETA ® nursing measure: Calibrating construct validity with ...

    African Journals Online (AJOL)

    Background: The BETA nursing measure has been introduced as a tool to routinely measure and monitor the outcomes of patients' activities of daily living in a restorative nursing care context. Objectives: To investigate the BETA's construct validity using the Rasch model with specific reference to the BETA's potential to be ...

  7. Rare and unexpected beta thalassemic mutations in Qazvin ...

    African Journals Online (AJOL)

    STORAGESEVER

    2010-01-04

    Jan 4, 2010 ... About 13 beta-globin mutations encompass 70 - 90% of mutation spectrum in Iran. These mutations are called common beta-globin mutations. The rest are rare or unknown mutations. The objective of this study was to identify and describe rare or unknown beta-globin mutations in Qazvin province. EDTA-.

  8. Transforming growth factor-beta: possible roles in Dupuytren's contracture

    NARCIS (Netherlands)

    Kloen, P.; Jennings, C. L.; Gebhardt, M. C.; Springfield, D. S.; Mankin, H. J.

    1995-01-01

    Transforming growth factor-beta (TGF-beta) is a multifunctional polypeptide that stimulates extracellular matrix deposition and fibroblast proliferation. Because both these features characterize Dupuytren's contracture, we investigated a possible role for TGF-beta in the etiology of this disorder.

  9. Induction of beta-lactamase production in Pseudomonas aeruginosa biofilm

    DEFF Research Database (Denmark)

    Giwercman, B; Jensen, E T; Høiby, N

    1991-01-01

    Imipenem induced high levels of beta-lactamase production in Pseudomonas aeruginosa biofilms. Piperacillin also induced beta-lactamase production in these biofilms but to a lesser degree. The combination of beta-lactamase production with other protective properties of the biofilm mode of growth...

  10. On the Bivariate Kummer-Beta Type IV Distribution

    NARCIS (Netherlands)

    Jacobs, R.; Bekker, A.; Human, S.W.

    2012-01-01

    In this article, the non central bivariate Kummer-beta Type IV distribution is introduced and derived via the Laplace transform of the non central bivariate beta distribution by Gupta et al. (2011 ). We focus on and discuss the central bivariate Kummer-beta Type IV distribution; this distribution is

  11. Stereoselective synthesis of nicotinamide beta-riboside and nucleoside analogs.

    Science.gov (United States)

    Franchetti, Palmarisa; Pasqualini, Michela; Petrelli, Riccardo; Ricciutelli, Massimo; Vita, Patrizia; Cappellacci, Loredana

    2004-09-20

    The beta-anomers of N-ribofuranosylnicotine-3-carboxamide (beta-NAR) and its nicotinic acid analog (beta-NaR) were obtained by stereoselective synthesis via glycosylation of the presilylated bases under Vorbruggen's protocol. A NAR analog, methylated in position 3 of the ribosylic moiety, is also reported.

  12. Polypeptides having beta-glucosidase activity and polynucleotides encoding same

    Energy Technology Data Exchange (ETDEWEB)

    Morant, Marc

    2014-01-14

    The present invention relates to isolated polypeptides having beta-glucosidase activity, beta-xylosidase, or beta-glucosidase activity and isolated polynucleotides encoding polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

  13. Rare and unexpected beta thalassemic mutations in Qazvin ...

    African Journals Online (AJOL)

    About 13 beta-globin mutations encompass 70 - 90% of mutation spectrum in Iran. These mutations are called common beta-globin mutations. The rest are rare or unknown mutations. The objective of this study was to identify and describe rare or unknown beta-globin mutations in Qazvin province. EDTAcontaining venous ...

  14. Accumulation of poly-beta-hydroxybutyrate in Spirulina platensis.

    OpenAIRE

    Campbell, J; Stevens, S E; Balkwill, D L

    1982-01-01

    Poly-beta-hydroxybutyrate has been identified in the cyanobacterium Spirulina platensis. The addition of reduced carbon compounds to the growth medium was not required for poly-beta-hydroxybutyrate accumulation. Poly-beta-hydroxybutyrate accumulated during exponential growth to 6% of the total dry weight and then decreased during the stationary phase.

  15. Detection of Extended Spectrum Beta-Lactamases in Gram Negative ...

    African Journals Online (AJOL)

    Detection of Extended Spectrum Beta-Lactamases in Gram Negative Bacilli from Clinical Specimens in a Teaching Hospital in South Eastern Nigeria. ... generation cephalosporins used but 40 (16%) actually produced the extended spectrum beta- lactamase enzymes. This shows the existence of Extended Spectrum Beta- ...

  16. Association of the tetraspanin CD151 with the laminin-binding integrins alpha3beta1, alpha6beta1, alpha6beta4 and alpha7beta1 in cells in culture and in vivo

    NARCIS (Netherlands)

    Sterk, Lotus M. T.; Geuijen, Cecile A. W.; van den Berg, José G.; Claessen, Nike; Weening, Jan J.; Sonnenberg, Arnoud

    2002-01-01

    CD151 is a cell surface protein that belongs to the tetraspanin superfamily. It forms complexes with the laminin-binding integrins alpha3beta1, alpha6beta1 and alpha6beta4 and is codistributed with these integrins in many tissues at sites of cell-matrix interactions. In this study we show that CD151

  17. Altered Wnt signalling in the teenage suicide brain: focus on glycogen synthase kinase-3[beta] and [beta]-catenin

    National Research Council Canada - National Science Library

    Xinguo Ren; Hooriyah S Rizavi; Mansoor A Khan; Yogesh Dwivedi; Ghanshyam N Pandey

    2013-01-01

      Abstract Glycogen synthase kinase (GSK)-3[beta] and [beta]-catenin are important components of the Wnt signalling pathway, which is involved in numerous physiological functions such as cognition, brain development and cell survival...

  18. Agonist-induced desensitization of beta-adrenoceptor function in humans. Subtype-selective reduction in beta 1- or beta 2-adrenoceptor-mediated physiological effects by xamoterol or procaterol

    NARCIS (Netherlands)

    Brodde, O. E.; Daul, A.; Michel-Reher, M.; Boomsma, F.; Man in 't Veld, A. J.; Schlieper, P.; Michel, M. C.

    1990-01-01

    We investigated the effects of beta 2- (procaterol 2 x 50 micrograms/day for 9 days) and beta 1- (xamoterol 2 x 200 mg/day for 14 days) adrenoceptor agonists on lymphocyte beta 2-adrenoceptor density and beta 1- and beta 2-adrenoceptor in vivo function (assessed as isoprenaline-infusion-evoked

  19. Myocardial beta-adrenoceptor changes in heart failure: concomitant reduction in beta 1- and beta 2-adrenoceptor function related to the degree of heart failure in patients with mitral valve disease

    NARCIS (Netherlands)

    Brodde, O. E.; Zerkowski, H. R.; Doetsch, N.; Motomura, S.; Khamssi, M.; Michel, M. C.

    1989-01-01

    In patients suffering from end-stage congestive cardiomyopathy, cardiac beta 1-adrenoceptor function is markedly reduced, whereas cardiac beta 2-adrenoceptor function is nearly normal. To determine whether beta 1-adrenoceptor function is impaired in heart failure selectively, beta 1- and beta

  20. Heterozygous beta-thalassemia: relationship between the hematological phenotype and the type of beta-thalassemia mutation.

    Science.gov (United States)

    Rosatelli, C; Leoni, G B; Tuveri, T; Scalas, M T; Mosca, A; Galanello, R; Gasperini, D; Cao, A

    1992-01-01

    In this study we have correlated the severity of the hematological features to the type of the beta-thalassemia mutation [codon 39 (C----T), IVS-I nt 110 (G----A), IVS-I nt 1 (G----A), IVS-I nt 6 (T----C), IVS-II nt 745 (C----G), -87 (C----G) and beta 6 (-1 bp)], in a group of beta-thalassemia heterozygotes of Italian descent in whom we excluded the presence of iron deficiency or deletion alpha-thalassemia. The beta-thalassemia mutation was defined by dot blot analysis on amplified DNA with allelic specific oligonucleotide probes. We found that a) heterozygotes for beta+ IVS-I nt 6 and beta+ -87 mutations produce larger and better hemoglobinized red blood cells, and b) heterozygotes for beta+ IVS-I nt 6 and beta+ IVS-I nt 110 mutations have a less marked increase of Hb A2 levels as compared to heterozygotes for the other mutations investigated. These findings indicate that milder beta-thalassemia mutations such as the beta+ IVS-I nt 6 and beta+ -87, express also in the heterozygous state a milder phenotype as compared to beta o-thalassemia or severe beta+ thalassemia (beta+ IVS-I, nt 110). The Hb A2 levels, on the other hand, were not related to the severity of the mutation because of less marked increase was found in a mild (beta+ IVS-I nt 6) as well in a severe (beta+ IVS-I nt 110) mutation. From the practical point of view these findings should be adequately considered in carrier screening and genetic counselling.

  1. Des-Lys58-beta 2m and native beta 2m in rheumatoid arthritis serum and synovial fluid

    DEFF Research Database (Denmark)

    Williams, R C; Malone, C C; Nissen, Mogens Holst

    1995-01-01

    OBJECTIVE. Levels of beta 2-microglobulin and modified beta 2-microglobulin (Des-Lys58-beta 2m) were measured in serum and synovial fluids from patients with rheumatoid arthritis (RA) and other inflammatory joint disorders using rabbit antisera prepared against the beta 2m peptide VEHSDLSFS...... encompassing residues 49-57 and absorbed with the C-terminal beta 2m peptide (87-97) LSQPKIVKWDR. These antisera which did not react with native beta 2m were employed to quantitate Des-Lys58-beta 2m in serum and SF. Native beta 2m was measured using a direct ELISA method. RESULTS. Removal of serum rheumatoid...... factor by adsorption to monomeric IgG columns did not change serum levels of beta 2m or Des-Lys58-beta 2m. Native beta 2m was found in all of 20 RA sera, but only rarely in SLE sera. No serum beta 2m was found in 20 patients with ankylosing spondylitis or 25 normal controls. Significant elevations of Des...

  2. Positive-negative epitope-tagging of beta amyloid precursor protein to identify inhibitors of A beta processing.

    Science.gov (United States)

    Seiffert, D; Mitchell, T; Stern, A M; Roach, A; Zhan, Y; Grzanna, R

    2000-12-08

    In this report, a novel positive-negative epitope tagging approach was developed to study the cellular processing of beta amyloid precursor protein (beta APP). Amino acids centered around the alpha-secretase cleavage site within the A beta sequence were replaced with residues comprising an epitope for which high-affinity monoclonal antibodies are commercially available. The resulting mutant beta APP cDNAs were expressed in human embryonic kidney cells (HEK 293). Cleavage of labeled beta APP by beta- and gamma-secretase(s) results in the release of an epitope-tagged A beta peptide, whereas cleavage by alpha-secretase results in destruction of the epitope. Highly sensitive and specific immunoassays were developed to study processing of this labeled beta APP via the amyloidogenic pathway. Secretion of epitope-tagged A beta was prevented by MDL 28170, a previously described gamma-secretase inhibitor. Confocal microscopic studies revealed that processing and cellular trafficking of epitope-tagged beta APP was not different from wild-type beta APP. These results suggest that positive-negative epitope-tagged beta APP is normally processed within the cell and may be used to identify secretase inhibitors as therapeutics for Alzheimer's disease.

  3. Strain-dependent differences in sensitivity of rat beta-cells to interleukin 1 beta in vitro and in vivo

    DEFF Research Database (Denmark)

    Reimers, J I; Andersen, H U; Mauricio, D

    1996-01-01

    The aim of this study was to investigate whether strain-dependent differences in beta-cell sensitivity to interleukin (IL) 1 beta exist in vitro and in vivo and if so, whether these differences correlate to variations in IL-1 beta-induced islet inducible nitric oxide synthase (iNOS) mRNA expression...

  4. Induction of transforming growth factor beta-1 in cervical intraepithelial neoplasia in vivo after treatment with beta-carotene.

    Science.gov (United States)

    Comerci, J T; Runowicz, C D; Fields, A L; Romney, S L; Palan, P R; Kadish, A S; Goldberg, G L

    1997-02-01

    Transforming growth factor (TGF) beta1 is a potent growth inhibitor of epithelial cells. Loss of responsiveness to TGF-beta1 and/or loss of TGF-beta1 itself may be important in the progression of cervical intraepithelial neoplasia to invasive cervical cancer. Retinoids have antiproliferative effects on epithelial cells and have been used as chemopreventive and chemotherapeutic agents for several human cancers. There is evidence that retinoids exert their effects by promoting the induction of TGF-beta. The aim of this study was to determine whether the expression of TGF-beta1 was altered in patients enrolled in a clinical trial designed to test the therapeutic efficacy of beta-carotene, a carotenoid metabolized to retinol, in cervical intraepithelial neoplasia. Using an immunohistochemical technique, tissues were stained with two types of antisera that react with the intracellular and extracellular forms of TGF-beta1. Matched cervical biopsies taken from 10 patients before and after treatment with beta-carotene were immunostained simultaneously to allow direct comparison of relative staining intensity. A significant increase in intracellular TGF-beta1 immunoreactivity was noted in cervical epithelial cells in patients with cervical intraepithelial neoplasia after treatment with beta-carotene (P = 0.003). These results demonstrate regulation of a TGF-beta isoform in vivo in humans in response to beta-carotene administered as a chemopreventive agent.

  5. Release of beta-lipotropin- and beta-endorphin-like material induced by angiotensin in the conscious rat

    NARCIS (Netherlands)

    Beuers, U.; HERTTING, G.; KNEPEL, W.

    1982-01-01

    1 The influence of the renin-angiotensin system on plasma beta-endorphin-like immunoreactivity (beta-EI) was investigated in the conscious rat by use of a radioimmunoassay for beta-endorphin without prior extraction.2 Intravenous infusion of angiotensin I, II or (des-1-Asp)angiotensin II

  6. Beta-lactam versus beta-lactam-aminoglycoside combination therapy in cancer patients with neutropenia.

    Science.gov (United States)

    Paul, Mical; Dickstein, Yaakov; Schlesinger, Agata; Grozinsky-Glasberg, Simona; Soares-Weiser, Karla; Leibovici, Leonard

    2013-06-29

    Continued controversy surrounds the optimal empirical treatment for febrile neutropenia. New broad-spectrum beta-lactams have been introduced as single treatment, and classically, a combination of a beta-lactam with an aminoglycoside has been used. To compare beta-lactam monotherapy versus beta-lactam-aminoglycoside combination therapy for cancer patients with fever and neutropenia. The Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library, Issue 7, 2012), LILACS (August 2012), MEDLINE and EMBASE (August 2012) and the Database of Abstracts of Reviews of Effects (DARE) (Issue 3, 2012). We scanned references of all included studies and pertinent reviews and contacted the first author of each included trial, as well as the pharmaceutical companies. Randomised controlled trials (RCTs) comparing any beta-lactam antibiotic monotherapy with any combination of a beta-lactam and an aminoglycoside antibiotic, for the initial empirical treatment of febrile neutropenic cancer patients. All cause mortality was the primary outcome assessed. Data concerning all cause mortality, infection related mortality, treatment failure (including treatment modifications), super-infections, adverse effects and study quality measures were extracted independently by two review authors. Risk ratios (RRs) with their 95% confidence intervals (CIs) were estimated. Outcomes were extracted by intention-to-treat (ITT) analysis whenever possible. Individual domains of risk of bias were examined through sensitivity analyses. Published data were complemented by correspondence with authors. Seventy-one trials published between 1983 and 2012 were included. All cause mortality was lower with monotherapy (RR 0.87, 95% CI 0.75 to 1.02, without statistical significance). Results were similar for trials comparing the same beta-lactam in both trial arms (11 trials, 1718 episodes; RR 0.74, 95% CI 0.53 to 1.06) and for trials comparing different beta-lactams-usually a broad-spectrum beta

  7. Beta Risk in the Cross-section of Equities

    DEFF Research Database (Denmark)

    Boloorforoosh, Ali; Christoffersen, Peter; Fournier, Mathieu

    We develop a bivariate stochastic volatility model that allows for dynamic market exposure. The expected return on a stock depends on beta's co-movement with the stochastic discount factor and deviates from the standard security market line when beta risk is priced. When estimating the model...... on returns and options for a large number of firms we find that allowing for beta risk helps explain the expected returns on low and high beta stocks that are challenging for standard factor models. Overall, we find strong evidence that accounting for beta risk results in better model fit....

  8. Radioprotective activity of some. beta. -hydroxylated indole-alkylamines

    Energy Technology Data Exchange (ETDEWEB)

    Deanovic, Z.; Trescec, A.; Kveder, S.; Iskric, S.; Supek, Z.

    1982-06-01

    Chain ..beta..-hydroxylated derivatives of tryptamine, 5-methoxytryptamine and 5-hydroxytryptamine (serotonin), respectively, were tested as radioprotectors in X-ray-irradiated mice. At midlethal dose of irradiation (725 cGy), tryptamine and serotonin protected all the animals, ..beta..-hydroxylated tryptamine was only slightly less effective (survival 85%). On the contrary, when mice were irradiated with absolutely lethal dose (900 cGy), only ..beta..-hydroxylated derivative of serotonin gave complete (100%) protection to the animals; 5-hydroxytryptamine and 5-methoxytryptamine protected about 90% of the animals. ..beta..-hydroxy-5-methosytryptamine 35%, tryptamine 29%, whereas ..beta..-hydroxytryptamine did not give any protection.

  9. Beta-lactamases of Mycobacterium tuberculosis and Mycobacterium kansasii.

    Science.gov (United States)

    Segura, C; Salvadó, M

    1997-09-01

    Re-emergence of infectious diseases caused by mycobacteria as well as the emergence of multiresistant strains of Mycobacterium has promoted the research on the use of beta-lactames in the treatment of such diseases. Mycobacteria produce beta-lactamases: M. tuberculosis produces a wide-spectrum beta-lactamase whose behaviour mimicks those of Gram-negative bacteria. M. kansasii produces also beta-lactamase which can be inhibited by clavulanic acid. An overview on beta-lactamases from both species is reported.

  10. Double Beta Decay Experiments with Thermal Detectors

    Science.gov (United States)

    Alessandrello, A.; Brofferio, C.; Cremonesi, O.; Fiorini, E.; Giuliani, A.; Nucciotti, A.; Pavan, M.; Pessina, G.; Pirro, S.; Previtali, E.; Vanzini, M.; Zanotti, L.; Bucci, C.

    2001-05-01

    Massive low temperature particle detectors and their possible impacts on searches for neutrinoless double beta decay (O-DBD) are presented and discussed. In particular, the experimental work of the Milano group is described. Special relevance is given to the present status of the search for O-DBD of 130Te and to the possible expansion of this experiment in the near future. The most recent results obtained by the Milano-Gran Sasso collaboration with a 20 bolometer array are presented. On the basis of these results, the construction of a 42 kg array consisting of 56 TeO2 bolometers (CUORICINO project), to extend the sensitivity of the present experiment, has been proposed. CUORICINO should represent also a feasibility test for a large array of 1000 bolometers (CUORE project) aiming at the search for neutrinoless Double Beta Decay, Cold Dark Matter and Solar Axions with extremely high sensitivity.

  11. Resveratrol and Amyloid-Beta: Mechanistic Insights

    Directory of Open Access Journals (Sweden)

    Yongming Jia

    2017-10-01

    Full Text Available The amyloid-beta (Aβ hypothesis that dyshomeostasis between Aβ production and clearance is a very early, key molecular factor in the etiology of Alzheimer’s disease (AD has been proposed and examined in the AD research field. Scientists have focused on seeking natural products or drugs to influence the dynamic equilibrium of Aβ, targeting production and clearance of Aβ. There is emerging evidence that resveratrol (Res, a naturally occurring polyphenol mainly found in grapes and red wine, acts on AD in numerous in vivo and in vitro models. Res decreases the amyloidogenic cleavage of the amyloid precursor protein (APP, enhances clearance of amyloid beta-peptides, and reduces Aβ aggregation. Moreover, Res also protects neuronal functions through its antioxidant properties. This review discusses the action of Res on Aβ production, clearance and aggregation and multiple potential mechanisms, providing evidence of the useful of Res for AD treatment.

  12. Genetic counselling in the beta-thalassaemias

    Directory of Open Access Journals (Sweden)

    Adonis S. Ioannides

    2013-03-01

    Full Text Available The beta-thalassaemias are very important genetic disorders of haemoglobin synthesis and are amongst the commonest monogenic disorders. In view of the severity of beta-thalassaemia major, a number of screening programmes have been developed aimed at reducing the number of individuals born with the condition. Genetic counsellingplays a vital role in this process supporting the successful implementation of screening and delineating available options to at risk individuals. This review assesses the contribution of genetic counsellingat each stage of this process in the context of new diagnostic techniques and therapeutic options and discusses some of the more challenging aspects such as genotype/ phenotype correlation and coinheritance of other genetic conditions or genetic modifiers.

  13. Hypoglycemia Reduces Vascular Endothelial Growth Factor A Production by Pancreatic Beta Cells as a Regulator of Beta Cell Mass*

    Science.gov (United States)

    Xiao, Xiangwei; Guo, Ping; Chen, Zean; El-Gohary, Yousef; Wiersch, John; Gaffar, Iljana; Prasadan, Krishna; Shiota, Chiyo; Gittes, George K.

    2013-01-01

    VEGF-A expression in beta cells is critical for pancreatic development, formation of islet-specific vasculature, and Insulin secretion. However, two key questions remain. First, is VEGF-A release from beta cells coupled to VEGF-A production in beta cells? Second, how is the VEGF-A response by beta cells affected by metabolic signals? Here, we show that VEGF-A secretion, but not gene transcription, in either cultured islets or purified pancreatic beta cells, was significantly reduced early on during low glucose conditions. In vivo, a sustained hypoglycemia in mice was induced with Insulin pellets, resulting in a significant reduction in beta cell mass. This loss of beta cell mass could be significantly rescued with continuous delivery of exogenous VEGF-A, which had no effect on beta cell mass in normoglycemic mice. In addition, an increase in apoptotic endothelial cells during hypoglycemia preceded an increase in apoptotic beta cells. Both endothelial and beta cell apoptosis were prevented by exogenous VEGF-A, suggesting a possible causative relationship between reduced VEGF-A and the loss of islet vasculature and beta cells. Furthermore, in none of these experimental groups did beta cell proliferation and islet vessel density change, suggesting a tightly regulated balance between these two cellular compartments. The average islet size decreased in hypoglycemia, which was also prevented by exogenous VEGF-A. Taken together, our data suggest that VEGF-A release in beta cells is independent of VEGF-A synthesis. Beta cell mass can be regulated through modulated release of VEGF-A from beta cells based on physiological need. PMID:23378532

  14. Hypoglycemia reduces vascular endothelial growth factor A production by pancreatic beta cells as a regulator of beta cell mass.

    Science.gov (United States)

    Xiao, Xiangwei; Guo, Ping; Chen, Zean; El-Gohary, Yousef; Wiersch, John; Gaffar, Iljana; Prasadan, Krishna; Shiota, Chiyo; Gittes, George K

    2013-03-22

    VEGF-A expression in beta cells is critical for pancreatic development, formation of islet-specific vasculature, and Insulin secretion. However, two key questions remain. First, is VEGF-A release from beta cells coupled to VEGF-A production in beta cells? Second, how is the VEGF-A response by beta cells affected by metabolic signals? Here, we show that VEGF-A secretion, but not gene transcription, in either cultured islets or purified pancreatic beta cells, was significantly reduced early on during low glucose conditions. In vivo, a sustained hypoglycemia in mice was induced with Insulin pellets, resulting in a significant reduction in beta cell mass. This loss of beta cell mass could be significantly rescued with continuous delivery of exogenous VEGF-A, which had no effect on beta cell mass in normoglycemic mice. In addition, an increase in apoptotic endothelial cells during hypoglycemia preceded an increase in apoptotic beta cells. Both endothelial and beta cell apoptosis were prevented by exogenous VEGF-A, suggesting a possible causative relationship between reduced VEGF-A and the loss of islet vasculature and beta cells. Furthermore, in none of these experimental groups did beta cell proliferation and islet vessel density change, suggesting a tightly regulated balance between these two cellular compartments. The average islet size decreased in hypoglycemia, which was also prevented by exogenous VEGF-A. Taken together, our data suggest that VEGF-A release in beta cells is independent of VEGF-A synthesis. Beta cell mass can be regulated through modulated release of VEGF-A from beta cells based on physiological need.

  15. Transforming growth factor-beta1 (TGF-beta1) induces human osteoclast apoptosis by up-regulating Bim.

    Science.gov (United States)

    Houde, Nicolas; Chamoux, Estelle; Bisson, Martine; Roux, Sophie

    2009-08-28

    Transforming growth factor-beta1 (TGF-beta1) is the most abundant TGF-beta isoform detected in bone and is an important functional modulator of osteoclasts. TGF-beta1 can induce osteoclast apoptosis; however, the apoptotic pathways involved in this process are not known. We show here that human osteoclasts express both type-I and type-II TGF-beta receptors. In the absence of survival factors, TGF-beta1 (1 ng/ml) induced osteoclast apoptosis. The expression of activated caspase-9, but not that of caspase-8, was increased by TGF-beta1 stimulation, and the rate of TGF-beta1-induced apoptosis was significantly lower in the presence of a caspase-9 inhibitor. To study further the mechanisms involved in TGF-beta1-induced osteoclast apoptosis, we investigated TGF-beta1 signaling, which primarily involves the Smad pathway, but also other pathways that may interfere with intracellular modulators of apoptosis, such as mitogen-activated protein (MAP) kinases and Bcl2 family members. We show here that early events consisted of a trend toward increased expression of extracellular signal-regulated kinase (ERK), and then TGF-beta1 significantly induced the activation of p38 and Smad2 in a time-dependent manner. These signaling cascades may activate the intrinsic apoptosis pathway, which involves Bim, the expression of which was increased in the presence of TGF-beta1. Furthermore, the rate of TGF-beta1-induced osteoclast apoptosis was lower when Bim expression was suppressed, and inhibiting the Smad pathway abolished Bim up-regulation following TGF-beta stimulation. This could correspond to a regulatory mechanism involved in the inhibition of osteoclast activity by TGF-beta1.

  16. High beta and confinement studies on TFTR

    Energy Technology Data Exchange (ETDEWEB)

    Navratil, G.A.; Bhattacharjee, A.; Iacono, R.; Mauel, M.E.; Sabbagh, S.A. (Columbia Univ., New York, NY (United States)); Kesner, J. (Massachusetts Inst. of Tech., Cambridge, MA (United States))

    1992-01-01

    A new regime of high poloidal beta operation in TFTR was developed in the course of the first two years of this project (9/25/89 to 9/24/91). Our proposal to continue this successful collaboration between Columbia University and the Massachusetts Institute of Technology with the Princeton Plasma Physics Laboratory for a three year period (9/25/91 to 9/24/94) to continue to investigate improved confinement and tokamak performance in high poloidal beta plasmas in TFTR through the DT phase of operation was approved by the DOE and this is a report of our progress during the first 9 month budget period of the three year grant (9/25/91 to 6/24/92). During the approved three year project period we plan to (1) extend and apply the low current, high QDD discharges to the operation of TFTR using Deuterium and Tritium plasma; (2) continue the analysis and plan experiments on high poloidal beta phenomena in TFTR including: stability properties, enhanced global confinement, local transport, bootstrap current, and divertor formation; (3) plan and carry out experiments on TFTR which attempt to elevate the central q to values > 2 where entry to the second stability regime is predicted to occur; and (4) collaborate on high beta experiments using bean-shaped plasmas with a stabilizing conducting shell in PBX-M. In the seven month period covered by this report we have made progress in each of these four areas through the submission of 4 TFTR Experimental Proposals and the partial execution of 3 of these using a total of 4.5 run days during the August 1991 to February 1992 run.

  17. STREPTOCOQUE BETA HEMOLYTIQUE DU GROUPE B ET ...

    African Journals Online (AJOL)

    cervico-vaginal au cours du suivi prénatal en pays pauvre très endetté. MOTS CLES: Prélèvement cervico-vaginal - Streptocoque â-hémolytique du groupe B - Transmission materno-fœtale - Rupture prématurée des membranes - Infection néonatale. GROUP B BETA HEMOLYTIC STREPTOCOCCUS IN PREGNANCY AND ...

  18. Conformational properties of beta-PrP.

    Science.gov (United States)

    Hosszu, Laszlo L P; Trevitt, Clare R; Jones, Samantha; Batchelor, Mark; Scott, David J; Jackson, Graham S; Collinge, John; Waltho, Jonathan P; Clarke, Anthony R

    2009-08-14

    Prion propagation involves a conformational transition of the cellular form of prion protein (PrPC) to a disease-specific isomer (PrPSc), shifting from a predominantly alpha-helical conformation to one dominated by beta-sheet structure. This conformational transition is of critical importance in understanding the molecular basis for prion disease. Here, we elucidate the conformational properties of a disulfide-reduced fragment of human PrP spanning residues 91-231 under acidic conditions, using a combination of heteronuclear NMR, analytical ultracentrifugation, and circular dichroism. We find that this form of the protein, which similarly to PrPSc, is a potent inhibitor of the 26 S proteasome, assembles into soluble oligomers that have significant beta-sheet content. The monomeric precursor to these oligomers exhibits many of the characteristics of a molten globule intermediate with some helical character in regions that form helices I and III in the PrPC conformation, whereas helix II exhibits little evidence for adopting a helical conformation, suggesting that this region is a likely source of interaction within the initial phases of the transformation to a beta-rich conformation. This precursor state is almost as compact as the folded PrPC structure and, as it assembles, only residues 126-227 are immobilized within the oligomeric structure, leaving the remainder in a mobile, random-coil state.

  19. Nuclear Data Compilation for Beta Decay Isotope

    Science.gov (United States)

    Olmsted, Susan; Kelley, John; Sheu, Grace

    2015-10-01

    The Triangle Universities Nuclear Laboratory nuclear data group works with the Nuclear Structure and Decay Data network to compile and evaluate data for use in nuclear physics research and applied technologies. Teams of data evaluators search through the literature and examine the experimental values for various nuclear structure parameters. The present activity focused on reviewing all available literature to determine the most accurate half-life values for beta unstable isotopes in the A = 3-20 range. This analysis will eventually be folded into the ENSDF (Evaluated Nuclear Structure Data File). By surveying an accumulated compilation of reference articles, we gathered all of the experimental half-life values for the beta decay nuclides. We then used the Visual Averaging Library, a data evaluation software package, to find half-life values using several different averaging techniques. Ultimately, we found recommended half-life values for most of the mentioned beta decay isotopes, and updated web pages on the TUNL webpage to reflect these evaluations. To summarize, we compiled and evaluated literature reports on experimentally determined half-lives. Our findings have been used to update information given on the TUNL Nuclear Data Evaluation group website. This was an REU project with Triangle Universities Nuclear Laboratory.

  20. The Aggregation Potential of the 1-15-and 1-16-Fragments of the Amyloid beta Peptide and Their Influence on the Aggregation of A beta 40

    NARCIS (Netherlands)

    Shabestari, M.; Plug, T.; Motazacker, M. M.; Meeuwenoord, N. J.; Filippov, D. V.; Meijers, J. C. M.; Huber, M.

    2013-01-01

    The aggregation of amyloid beta (A beta) peptide is important in Alzheimer's disease. Shorter A beta fragments may reduce A beta's cytotoxicity and are used in diagnostics. The aggregation of A beta 16 is controversial; Liu et al. (J. Neurosci. Res. 75:162-171, 2004) and Liao et al. (FEBS Lett.

  1. Efeito da teofilina associada ao beta2-agonista inalatório de curta ou longa duração, em pacientes com doença pulmonar obstrutiva crônica estável: revisão sistemática Effect of theophylline associated with short-acting or long-acting inhaled beta2-agonists in patients with stable chronic obstructive pulmonary disease: a systematic review

    Directory of Open Access Journals (Sweden)

    Eliane Cristina Zacarias

    2007-04-01

    Full Text Available OBJETIVOS: Avaliar se o tratamento com teofilina associada ao beta2-agonista inalatório de curta ou longa duração é mais eficaz que o placebo e que o uso isolado de cada um dos fármacos, para os pacientes com doença pulmonar obstrutiva crônica estável. MÉTODOS: Realizou-se uma revisão sistemática com metanálise, sendo selecionados todos os ensaios clínicos aleatórios e duplo-cegos encontrados na literatura. RESULTADOS: Foram incluídos oito estudos. Teofilina associada ao beta2-agonista vs. placebo: houve melhora estatisticamente significante para o VEF1 (L, com média 0,27 (IC95% 0,11 a 0,43; e para a dispnéia, com média -0,78 (IC95% -1,26 a -0,29. Teofilina associada ao beta2-agonista vs. beta2-agonista isolado: nenhuma das metanálises realizadas detectou diferença entre os grupos. Teofilina associada ao beta2-agonista vs. teofilina isolada: houve melhora estatisticamente significante para a dispnéia, com média -0,19 (IC95% -0,34 a -0,04. CONCLUSÕES: Em pacientes com doença pulmonar obstrutiva crônica estável: 1 teofilina associada ao beta2-agonista é mais eficaz que o placebo, em relação ao VEF1 e dispnéia; 2a teofilina associada ao beta2-agonista é mais eficaz que a teofilina isolada, em relação à dispnéia; e 2b teofilina associada ao beta2-agonista não é mais eficaz que o beta2-agonista isolado, para quaisquer das variáveis estudadas.OBJECTIVES: To determine whether, in stable patients with chronic obstructive pulmonary disease, administration of theophylline in combination with short-acting or long-acting inhaled beta2-agonists is more efficacious than is a placebo or each of these drugs used in isolation. METHODS: A systematic review and meta-analysis were carried out. All randomized and double-blind clinical trials found in the literature were selected. RESULTS: A total of eight studies were included. In comparing the effect of theophylline combined with beta2-agonists to that of a placebo, we found a

  2. Form factors in the beta decay; Factores de forma en la desintegracion Beta

    Energy Technology Data Exchange (ETDEWEB)

    Grau Carles, A.; Grau Malonda, A.

    2007-07-01

    Beta-decay was one of the nuclear physics fields more active in the last century. This book has a didactic objective: to actualize some basic concepts related with form factors in beta-decay. Some accepted points before 1957 are not valid today due to the non conservation of parity and the full acceptation of V-A interaction in beta-decay. To compute theoretically beta-decay observables one has to relate the form factors to transition matrix elements. The form factors are expressed in terms of nuclear matrix elements when some approximations are made. We assume that the nucleon inside the nucleus interact with leptons in the same way as free punctual electrons do. Consequently, the Dirac equation of a free particle is assumed. We compute the shape form factors for several forbidden transitions. A very important part of the book is the 106 examples, fully developed, which clarify the ideas and motivate one to know the different computation methods used in beta-decay and others nuclear and atomic fields. (Author) 50 refs.

  3. Isolation and characterization of TGF-beta 2 and TGF-beta 5 from medium conditioned by Xenopus XTC cells.

    Science.gov (United States)

    Roberts, A B; Rosa, F; Roche, N S; Coligan, J E; Garfield, M; Rebbert, M L; Kondaiah, P; Danielpour, D; Kehrl, J H; Wahl, S M

    1990-01-01

    TGF-beta 2 and -beta 5 have been purified from medium conditioned by Xenopus cultured cells (XTC) and identified based on their N-terminal amino acid sequence analysis and biological activity. When applied in high concentrations, Xenopus TGF-beta 2, like porcine TGF-beta 2, induces expression of mesodermal markers from cultured Xenopus ectodermal explants, whereas TGF-beta 5 is inactive in this assay. However, the TGF-beta 's could be separated from the major mesoderm-inducing activity present in XTC medium. Xenopus TGF-beta 2 and -beta 5 are approximately equivalent to TGF-beta 1 in their abilities to inhibit the growth of mink lung CCL-64 cells, induce anchorage-independent growth of rat NRK cells, inhibit the proliferation and antibody secretion of human B-lymphocytes, and stimulate chemotaxis of human monocytes. These data establish the functional activity of TGF-beta 5 and suggest that more complex multicellular systems, in contrast to most isolated cells, discriminate between the different TGF-beta s.

  4. Estrategias para negociaciones exitosas.

    Directory of Open Access Journals (Sweden)

    José B. Parra V

    2010-01-01

    Full Text Available Las estrategias de negociación son herramientas para disminuir conflictos o para intercambiar bienes y servicios. Una negociación exitosa crea relaciones de solidaridad y propicia reciprocidad, cooperación y confianza para quienes tendrán relaciones permanentes de negociación con beneficios para ambas partes. Una estrategia de negociación exitosa requiere manejar el desarrollo del ambiente social del grupo de personas, con la finalidad de tener presente las fronteras que no pueden irrumpirse. Otro aspecto importante, es el lenguaje corporal utilizado por las personas y las tácticas que se practican. El manejo de esta información permite diseñar diferentes modelos de negociaciones para cada caso específico. Este documento propone la utilización de la herramienta MONACO, diseñada por los autores, que es un software útil para encontrar los mejores tácticas posibles dentro de una negociación; basándose en el lenguaje corporal que muestra el negociante oponente durante cada oferta monetaria. El uso de este software da al negociador la oportunidad de manejar las negociaciones con mayor control, el negociador que usa el software puede elegir una estrategia de acuerdo a las relaciones que espera mantener con el negociador oponente.

  5. Interactions between beta subunits of the KCNMB family and Slo3: beta4 selectively modulates Slo3 expression and function.

    Directory of Open Access Journals (Sweden)

    Cheng-Tao Yang

    2009-07-01

    Full Text Available The pH and voltage-regulated Slo3 K(+ channel, a homologue of the Ca(2+- and voltage-regulated Slo1 K(+ channel, is thought to be primarily expressed in sperm, but the properties of Slo3 studied in heterologous systems differ somewhat from the native sperm KSper pH-regulated current. There is the possibility that critical partners that regulate Slo3 function remain unidentified. The extensive amino acid identity between Slo3 and Slo1 suggests that auxiliary beta subunits regulating Slo1 channels might coassemble with and modulate Slo3 channels. Four distinct beta subunits composing the KCNMB family are known to regulate the function and expression of Slo1 Channels.To examine the ability of the KCNMB family of auxiliary beta subunits to regulate Slo3 function, we co-expressed Slo3 and each beta subunit in heterologous expression systems and investigated the functional consequences by electrophysiological and biochemical analyses. The beta4 subunit produced an 8-10 fold enhancement of Slo3 current expression in Xenopus oocytes and a similar enhancement of Slo3 surface expression as monitored by YFP-tagged Slo3 or biotin labeled Slo3. Neither beta1, beta2, nor beta3 mimicked the ability of beta4 to increase surface expression, although biochemical tests suggested that all four beta subunits are competent to coassemble with Slo3. Fluorescence microscopy from beta4 KO mice, in which an eGFP tag replaced the deleted exon, revealed that beta4 gene promoter is active in spermatocytes. Furthermore, quantitative RT-PCR demonstrated that beta4 and Slo3 exhibit comparable mRNA abundance in both testes and sperm.These results argue that, for native mouse Slo3 channels, the beta4 subunit must be considered as a potential interaction partner and, furthermore, that KCNMB subunits may have functions unrelated to regulation of the Slo1 alpha subunit.

  6. Caracterização físico-química de complexos de insulina: dimetil-beta-ciclodextrina e insulina: hidroxipropil-beta-ciclodextrina e avaliação da influência do tipo de complexo na produção de microesferas biodegradáveis Physico-chemical caracterization of insulin: dimethyl-beta-cyclodextrin and insulin:hydroxypropil-beta-cyclodextrin complexes and evaluation of the kind of complexes on the biodegradable microspheres preparation

    Directory of Open Access Journals (Sweden)

    Viviane Conceição Fernandes

    2007-12-01

    Full Text Available A etapa principal na ativação e ligação da insulina ao seu receptor é a dissociação dos hexâmeros do hormônio, normalmente presente nas preparações farmacêuticas, para a forma monomérica bioativa. A utilização de diferentes ciclodextrinas (CDs como adjuvantes em formulações contendo insulina vem sendo explorada e os estudos realizados demonstram que estas substâncias podem aumentar a absorção da insulina principalmente por diminuírem sua capacidade de formar dímeros e hexâmeros em meio aquoso. No presente trabalho, complexos de insulina:hidroxipropil-beta-ciclodextrina (INS:HP-beta-CD e insulina:dimetil-beta-ciclodextrina (INS:DM-beta-CD foram caracterizados utilizando técnicas de titulação calorimétrica isotérmica e espalhamento dinâmico de luz. Por meio da titulação calorimétrica foram determinados os parâmetros termodinâmicos de interação entre a insulina e as CDs utilizadas, sugerindo que o mecanismo de complexação ocorre com aumento de entropia para ambos os sistemas. Os experimentos de espalhamento dinâmico de luz não indicaram diminuição do diâmetro hidrodinâmico das espécies moleculares de insulina após a complexação com as CDs. Os complexos INS:HP-beta-CD e INS:DM-beta-CD foram encapsulados em microesferas (MEs de PLGA 50:50. A caracterização das MEs obtidas revelou aumento considerável na taxa de encapsulamento de insulina quando complexada com as CDs sem que ocorresse diferença significativa no diâmetro das partículas em função da complexação.The main stage in the linking and activation of the specific receptors by the insulin is the dissociation of this peptide hexamers, normally present in pharmaceutical formulations, in the monomeric active form. Because of this, the use of different cyclodextrins as adjuvants in the formulations containing insulin has been explored and the realized studies have demonstrated that the cyclodextrins can increase the absorption of the insulin

  7. A Novel Dimeric Inhibitor Targeting Beta2GPI in Beta2GPI/Antibody Complexes Implicated in Antiphospholipid Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    A Kolyada; C Lee; A De Biasio; N Beglova

    2011-12-31

    {beta}2GPI is a major antigen for autoantibodies associated with antiphospholipid syndrome (APS), an autoimmune disease characterized by thrombosis and recurrent pregnancy loss. Only the dimeric form of {beta}2GPI generated by anti-{beta}2GPI antibodies is pathologically important, in contrast to monomeric {beta}2GPI which is abundant in plasma. We created a dimeric inhibitor, A1-A1, to selectively target {beta}2GPI in {beta}2GPI/antibody complexes. To make this inhibitor, we isolated the first ligand-binding module from ApoER2 (A1) and connected two A1 modules with a flexible linker. A1-A1 interferes with two pathologically important interactions in APS, the binding of {beta}2GPI/antibody complexes with anionic phospholipids and ApoER2. We compared the efficiency of A1-A1 to monomeric A1 for inhibition of the binding of {beta}2GPI/antibody complexes to anionic phospholipids. We tested the inhibition of {beta}2GPI present in human serum, {beta}2GPI purified from human plasma and the individual domain V of {beta}2GPI. We demonstrated that when {beta}2GPI/antibody complexes are formed, A1-A1 is much more effective than A1 in inhibition of the binding of {beta}2GPI to cardiolipin, regardless of the source of {beta}2GPI. Similarly, A1-A1 strongly inhibits the binding of dimerized domain V of {beta}2GPI to cardiolipin compared to the monomeric A1 inhibitor. In the absence of anti-{beta}2GPI antibodies, both A1-A1 and A1 only weakly inhibit the binding of pathologically inactive monomeric {beta}2GPI to cardiolipin. Our results suggest that the approach of using a dimeric inhibitor to block {beta}2GPI in the pathological multivalent {beta}2GPI/antibody complexes holds significant promise. The novel inhibitor A1-A1 may be a starting point in the development of an effective therapeutic for antiphospholipid syndrome.

  8. Evaluation of thrombogenicity of beta-propiolactone/ultraviolet (beta-PL/UV) treated PPSB in chimpanzees

    Energy Technology Data Exchange (ETDEWEB)

    Kotitschke, R.; Stephan, W.; Prince, A.M.; Brotman, B.

    1983-05-01

    The thrombogenicity of beta-PL/UV-treated PPSB (factor IX concentrate) was evaluated in chimpanzees. PPSB isolated from beta-propiolactone-treated and UV-irradiated plasma was injected into chimpanzees at a dose of approximately 100 units/kg body weight. An FDA licensed PPSB preparation served as the negative control, and a preparation containing activated as well as precursor clotting factors served as the positive control. 15 minutes, 1 h, 4 h, and 24 h after the PPSB application the following parameters were determined in the chimpanzee blood: factors II, VII, IX, X, VIII, fibrinogen, AT III, thrombin coagulase, Quick value, APTT and platelet count. Neither the untreated control preparation, nor the PPSB isolated from beta-propiolactone-treated and UV-irradiated plasma, showed signs of thrombogenicity in the chimpanzee model. The positive control indicated that the chimpanzee is a suitable model for the thrombogenicity testing of activated clotting factors.

  9. Beta-decay rate and beta-delayed neutron emission probability of improved gross theory

    Science.gov (United States)

    Koura, Hiroyuki

    2014-09-01

    A theoretical study has been carried out on beta-decay rate and beta-delayed neutron emission probability. The gross theory of the beta decay is based on an idea of the sum rule of the beta-decay strength function, and has succeeded in describing beta-decay half-lives of nuclei overall nuclear mass region. The gross theory includes not only the allowed transition as the Fermi and the Gamow-Teller, but also the first-forbidden transition. In this work, some improvements are introduced as the nuclear shell correction on nuclear level densities and the nuclear deformation for nuclear strength functions, those effects were not included in the original gross theory. The shell energy and the nuclear deformation for unmeasured nuclei are adopted from the KTUY nuclear mass formula, which is based on the spherical-basis method. Considering the properties of the integrated Fermi function, we can roughly categorized energy region of excited-state of a daughter nucleus into three regions: a highly-excited energy region, which fully affect a delayed neutron probability, a middle energy region, which is estimated to contribute the decay heat, and a region neighboring the ground-state, which determines the beta-decay rate. Some results will be given in the presentation. A theoretical study has been carried out on beta-decay rate and beta-delayed neutron emission probability. The gross theory of the beta decay is based on an idea of the sum rule of the beta-decay strength function, and has succeeded in describing beta-decay half-lives of nuclei overall nuclear mass region. The gross theory includes not only the allowed transition as the Fermi and the Gamow-Teller, but also the first-forbidden transition. In this work, some improvements are introduced as the nuclear shell correction on nuclear level densities and the nuclear deformation for nuclear strength functions, those effects were not included in the original gross theory. The shell energy and the nuclear deformation for

  10. In vitro proliferation of adult human beta-cells.

    Directory of Open Access Journals (Sweden)

    Sabine Rutti

    Full Text Available A decrease in functional beta-cell mass is a key feature of type 2 diabetes. Glucagon-like peptide 1 (GLP-1 analogues induce proliferation of rodent beta-cells. However, the proliferative capacity of human beta-cells and its modulation by GLP-1 analogues remain to be fully investigated. We therefore sought to quantify adult human beta-cell proliferation in vitro and whether this is affected by the GLP-1 analogue liraglutide.Human islets from 7 adult cadaveric organ donors were dispersed into single cells. Beta-cells were purified by FACS. Non-sorted cells and the beta-cell enriched ("beta-cells" population were plated on extracellular matrix from rat (804G and human bladder carcinoma cells (HTB9 or bovine corneal endothelial ECM (BCEC. Cells were maintained in culture+/-liraglutide for 4 days in the presence of BrdU.Rare human beta-cell proliferation could be observed either in the purified beta-cell population (0.051±0.020%; 22 beta-cells proliferating out of 84'283 beta-cells counted or in the non-sorted cell population (0.055±0.011%; 104 proliferating beta-cells out of 232'826 beta-cells counted, independently of the matrix or the culture conditions. Liraglutide increased human beta-cell proliferation on BCEC in the non-sorted cell population (0.082±0.034% proliferating beta-cells vs. 0.017±0.008% in control, p<0.05.These results indicate that adult human beta-cell proliferation can occur in vitro but remains an extremely rare event with these donors and particular culture conditions. Liraglutide increases beta-cell proliferation only in the non-sorted cell population and only on BCEC. However, it cannot be excluded that human beta-cells may proliferate to a greater extent in situ in response to natural stimuli.

  11. Thymosin beta 4 and thymosin beta 10 expression in hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    W. Theunissen

    2014-03-01

    Full Text Available Thymosin beta 4 (Tβ4 and thymosin beta 10 (Tβ10 are two members of the beta-thymosin family involved in many cellular processes such as cellular motility, angiogenesis, inflammation, cell survival and wound healing. Recently, a role for beta-thymosins has been proposed in the process of carcinogenesis as both peptides were detected in several types of cancer. The aim of the present study was to investigate the expression pattern of Tβ4 and Tβ10 in hepatocellular carcinoma (HCC. To this end, the expression pattern of both peptides was analyzed in liver samples obtained from 23 subjects diagnosed with HCC. Routinely formalin-fixed and paraffin-embedded liver samples were immunostained by indirect immunohistochemistry with polyclonal antibodies to Tβ4 and Tβ10. Immunoreactivity for Tβ4 and Tβ10 was detected in the liver parenchyma of the surrounding tumor area. Both peptides showed an increase in granular reactivity from the periportal to the periterminal hepatocytes. Regarding HCC, Tβ4 reactivity was detected in 7/23 cases (30% and Tβ10 reactivity in 22/23 (97% cases analyzed, adding HCC to human cancers that express these beta-thymosins. Intriguing finding was seen looking at the reactivity of both peptides in tumor cells infiltrating the surrounding liver. Where Tβ10 showed a strong homogeneous expression, was Tβ4 completely absent in cells undergoing stromal invasion. The current study shows expression of both beta-thymosins in HCC with marked differences in their degree of expression and frequency of immunoreactivity. The higher incidence of Tβ10 expression and its higher reactivity in tumor cells involved in stromal invasion indicate a possible major role for Tβ10 in HCC progression.

  12. Uso de la tierra y diversidades alfa, beta y gamma de diplópodos en la cuenca del río Otún, Colombia

    OpenAIRE

    Ruiz-Cobo, Darío Hernán; Grupo Gestión en Agroecosistemas Tropicales Andinos (GATA), Facultad de Ciencias Ambientales, Universidad Tecnológica de Pereira. Vereda La Julita A.A. 97, Pereira; Bueno-Villegas, Julián; Laboratorio de Sistemática Animal, Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Hidalgo. Km. 4.5 carretera Pachuca - Tulancingo S/N. Colonia Carboneras, Mineral de la Reforma, Hidalgo, 42184; Feijoo-Martínez, Alexander; Grupo Gestión en Agroecosistemas Tropicales Andinos (GATA), Facultad de Ciencias Ambientales, Universidad Tecnológica de Pereira. Vereda La Julita A.A. 97, Pereira

    2010-01-01

    Objetivo: Determinar la relación entre los cambios promovidos por la intervención humana en ecosistemas y grosistemas y la diversidad alfa, beta y gamma de Diplopoda de la cuenca media del río Otún. Materiales y métodos: Se utilizó un diseño sistemático estratificado con la selección de siete ventanas y 16 puntos de muestreo. Se separaron los diplópodos en familias y morfotipos para calcular la diversidad alfa, beta y gamma relacionada con la heterogeneidad de usos del terreno. Resultados: Se...

  13. Metabolic Stress and Compromised Identity of Pancreatic Beta Cells.

    Science.gov (United States)

    Swisa, Avital; Glaser, Benjamin; Dor, Yuval

    2017-01-01

    Beta cell failure is a central feature of type 2 diabetes (T2D), but the molecular underpinnings of the process remain only partly understood. It has been suggested that beta cell failure in T2D involves massive cell death. Other studies ascribe beta cell failure to cell exhaustion, due to chronic oxidative or endoplasmic reticulum stress leading to cellular dysfunction. More recently it was proposed that beta cells in T2D may lose their differentiated identity, possibly even gaining features of other islet cell types. The loss of beta cell identity appears to be driven by glucotoxicity inhibiting the activity of key beta cell transcription factors including Pdx1, Nkx6.1, MafA and Pax6, thereby silencing beta cell genes and derepressing alternative islet cell genes. The loss of beta cell identity is at least partly reversible upon normalization of glycemia, with implications for the reversibility of T2D, although it is not known if beta cell failure reaches eventually a point of no return. In this review we discuss current evidence for metabolism-driven compromised beta cell identity, key knowledge gaps and opportunities for utility in the treatment of T2D.

  14. Cardioprotection with beta-blockers: myths, facts and Pascal's wager.

    Science.gov (United States)

    Messerli, F H; Bangalore, S; Yao, S S; Steinberg, J S

    2009-09-01

    Beta-blockers were documented to reduce reinfarction rate more than 3 decades ago and subsequently touted as being cardioprotective for a broad spectrum of cardiovascular indications such as hypertension, diabetes, angina, atrial fibrillation as well as perioperatively in patients undergoing surgery. However, despite lowering blood pressure, beta-blockers have never shown to reduce morbidity and mortality in uncomplicated hypertension. Also, beta-blockers do not prevent heart failure in hypertension any better than any other antihypertensive drug class. Beta-blockers have been shown to increase the risk on new onset diabetes. When compared with nondiuretic antihypertensive drugs, beta-blockers increase all-cause mortality by 8% and stroke by 30% in patients with new onset diabetes. Beta-blockers are useful for rate control in patients with chronic atrial fibrillation but do not help restore sinus rhythm or have antifibrillatory effects in the atria. Beta-blockers provide symptomatic relief in patients with chronic stable angina but do not reduce the risk of myocardial infarction. Adverse effects of beta-blockers are common including fatigue, dizziness, depression and sexual dysfunction. However, beta-blockers remain a cornerstone in the management of patients having suffered a myocardial infarction and for patients with heart failure. Thus, recent evidence argues against universal cardioprotective properties of beta-blockers but attest to their usefulness for specific cardiovascular indications.

  15. Viscosity of beta-glucan in oat products

    Directory of Open Access Journals (Sweden)

    H. ANTTILA

    2008-12-01

    Full Text Available Oats contain 3-5% of mixed linked beta-glucan, or (1-3, (1-4 â-D-glucan, referred to hereafter as beta-glucan. Oat beta-glucan is a viscous, and soluble dietary fibre component. Soluble and viscous dietary fibres, including the beta-glucan present in oats are associated with two major health promoting effects, i.e. the attenuation of postprandial plasma glucose and insulin levels and the control of cholesterol. Increased viscosity in the intestine delays absorption of glucose and suppresses absorption of cholesterol and reabsorption of bile acids. In spite of its apparent key role physiologically the viscosity of beta-glucan has been discussed relatively little in terms of analytical procedures. In clinical studies performed with oats, the viscosity of beta-glucan has been properly documented in only a few cases. Viscosity of beta-glucan in foods and in the food digest depends on solubility, concentration and molecular weight. A food manufacturer aiming at health-promoting products must pay attention not only to sufficient concentration of beta-glucan (dose in the raw material, but also to the processing methods that will ensure sufficient solubility of beta-glucan and minimize enzymatic or mechanical breakdown of the beta-glucan molecule. We have been working both with different food processes utilising oat fractions high in beta-glucan and with the development of a method for viscosity determination of the soluble beta-glucan fibre. This review discusses some of the aspects related to the development with a method that could predict the behaviour of beta-glucan in oat processing with respect to its anticipated physiological functions.;

  16. [Phenotypes of beta-lactam resistance in the genus Aeromonas].

    Science.gov (United States)

    Fosse, T; Giraud-Morin, C; Madinier, I

    2003-07-01

    This work aimed to investigate resistance profiles towards beta-lactam antibiotics in correlation with beta-lactamases production in the genus Aeromonas. In a series of 417 wild-type strains, biochemical identification and testing with 11 beta-lactams by the disk-diffusion method revealed 5 predominant phenotypes: A. hydrophila complex/class B, C and D beta-lactamases; A. caviae complex/class C and D beta-lactamases; A. veronii complex/class B and D beta-lactamases; A. schubertii spp./class D beta-lactamase; A. trota spp./class C beta-lactamase. A subgroup of 64 representative strains was submitted to MIC determination with 8 beta-lactam compounds alone and in combination with 3 beta-lactamase inhibitors (clavulanic acid, tazobactam and BRL 42715). Visualisation of beta-lactamases and pI determination were performed in all these 64 isolates by isoelectric focusing from crude extracts. The different Aeromonas species produced 1 to 3 of the following inducible enzymes: an imipenemase with low expression, which is difficult to detect with routine phenotype studies (class B, pI 8, imipenem MIC > 2 micrograms/ml), a cephalosporinase (class C, pI > 7 +/- 0.5, cephalothin MIC > 256 micrograms/ml), and an oxacillinase widely produced in the genus Aeromonas (class D, pI > 8.5, ticarcillin MIC > 256 micrograms/ml). In Aeromonas spp. resistance profile to beta-lactam antibiotics is correlated with naturally occurring phenotypes of beta-lactamases production. As a conclusion, the characterisation of these different enzymes is of therapeutic and taxonomic interest, in species notoriously difficult to identify.

  17. Sizeable beta-strength in 31Ar(beta-3p) decay

    CERN Document Server

    Koldste, G.T.; Borge, M.J.G.; Briz, J.A.; Carmona-Gallardo, M.; Fraile, L.M.; Fynbo, H.O.U.; Giovinazzo, J.; Johansen, J.G.; Jokinen, A.; Jonson, B.; Kurturkian-Nieto, T.; Nilsson, T.; Perea, A.; Pesudo, V.; Picado, E.; Riisager, K.; Saastamoinen, A.; Tengblad, O.; Thomas, J.C.; Van de Walle, J.

    2014-01-01

    We present for the first time precise spectroscopic information on the recently discovered decay mode beta-delayed 3p-emission. The detection of the 3p events gives an increased sensitivity to the high energy part of the Gamow-Teller strength distribution from the decay of 31Ar revealing that as much as 30% of the strength resides in the beta-3p decay mode. A simplified description of how the main decay modes evolve as the excitation energy increases in 31Cl is provided.

  18. BETA. A code for {beta}{sub eff} measurement and analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Yuichi; Okajima, Shigeaki; Sakurai, Takeshi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1999-03-01

    The code BETA has been developed to calculate the following reactor physics parameters which are used for the {beta}{sub eff} measurement and analysis; Diven factor, Spatial correction factor (g-factor) for neutron correlation experiment, Adjoint weighted g-factor, Fission rate integrated in whole reactor and Adjoint weighted fission rate integrated in whole reactor: The code also calculates the effective delayed neutron fraction with different evaluated delayed neutron data. These parameters are calculated with using the forward and adjoint fluxes given by SLAROM, POPLARS or TWOTRAN-II. This report describes the input data and job control statements instructions, file requirements and sample input output data. (author)

  19. [beta]-Glucan synthesis in the cotton fiber. 1. Identification of [beta]1,4- and [beta]-1,3-glucans synthesized in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Okuda, Kazuo; Likun Li; Kudlicka, K.; Kuga, S.; Brown, R.M. Jr. (Univ. of Texas, Austin (United States))

    1993-04-01

    In vitro [beta]-glucan products were synthesized by digitonin-solubilized enzyme preparations from plasma membrane-enriched fractions of cotton (Gossypium hirsutum) fiber cells. The reaction mixture favoring [beta]-1,4-glucan synthesis included the following effectors: Mg[sup 2+], Ca[sup 2+], cellobiose, cyclic-3[prime]:5[prime]-GMP, and digitonin. The ethanol insoluble fraction from this reaction contained [beta]-1,4-glucan and [beta]-1,3-glucan in an approximate ratio of 25:69. Approximately 16% of the [beta]-1,4-glucan was resistant to the acetic/nitric acid reagent. The x-ray diffraction pattern of the treated product favoring [beta]-1,4-glucan synthesis strongly resembled that of cellulose 2. On the basis of methylation analysis, the acetic/nitric acid reagent-insoluble glucan product was found to be exclusively [beta]-1,4-linked. Enzymic hydrolysis confirmed that the product was hydrolyzed only by cellobiohydrolase 1. Autoradiography proved that the product was synthesized in vitro. The degree of polymerization (DP) of the in vitro product was estimated by nitration and size exclusion chromatography; there were two average DPs of 59 (70%) and 396 (30%) for the [beta]-1,3-glucanase-treated sample, and an average DP of 141 for the acetic/nitric acid reagent-insoluble product. On the basis of product analysis, the positive identification of in vitro-synthesized cellulose was established. 45 refs., 8 figs., 4 tabs.

  20. Influencia de la betarraga (Beta vulgaris var. cruenta en el aumento de leucocitos, en ratones

    Directory of Open Access Journals (Sweden)

    Jony Amaro

    2014-01-01

    Full Text Available Introducción: La betarraga es una planta oriunda del Mediterráneo utilizada para fines alimenticios y medicinales. Contiene flavonoides. Objetivos: Determinar la influencia del consumo del extracto de Beta vulgaris var. cruenta en el incremento de leucocitos, en el ratón albino. Diseño: Estudio experimental. Lugar: Bioterio de la Institución Educativa 1182. Material biológico: Veinte ratones albinos de la cepa balb/c, machos, de peso promedio 24 g. Intervenciones: Se formó dos grupos, experimental y control, cada uno de diez ratones. Al grupo experimental se le administró vía oral extracto de Beta vulgaris var. cruenta en dosis de 250 mg/kg, volumen de 2 mL, cada cinco horas durante una semana, alternando con nutrientes, y al grupo control solo se le administró nutrientes. Principales medidas de resultados: Recuento de leucocitos. Resultados: Dentro del periodo de acondicionamiento, se observó un ligero incremento en la media de leucocitos del grupo control (3 681 ± 431,1 frente al grupo experimental (3 579 ± 473,5, cuya diferencia no fue significativa. Luego de administrar al grupo experimental el extracto de Beta vulgaris var. cruenta, alternando con sus nutrientes respectivos, se observó diferencia significativa de la media (7 961 ± 275,4 frente al grupo control (3 693 ± 414,7 (t student p<0,05. Conclusiones: En condiciones experimentales, el consumo del extracto de Beta vulgaris var. cruenta incrementó significativamente el número de leucocitos.

  1. Identification of synthetic precursors of amphetamine-like drugs using Raman spectroscopy and ab initio calculations: beta-Methyl-beta-nitrostyrene derivatives

    OpenAIRE

    Milhazes, Nuno; Borges, Fernanda; Calheiros, Rita; Marques, M Paula M

    2004-01-01

    The present work reports a vibrational spectroscopic study of several beta-methyl-beta-nitrostyrene derivatives, which are important intermediates in the synthesis of illicit amphetamine-like drugs, such as 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyamphetamine (MDA), p-methoxyamphetamine (PMA) and 4-methylthioamphetamine (4-MTA). A complete conformational analysis of 3,4-methylenedioxy-beta-methyl-beta-nitrostyrene (3,4-MD-MeNS), 4-methoxy-beta-methyl-beta-nitrostyrene (4-Me...

  2. Structural studies of supramolecular photochemical beta-cyclodextrin inclusion complexes

    Science.gov (United States)

    Brett, Thomas John

    X-ray crystallography has played an essential role in our understanding of the factors controlling the outcomes of solid-state photochemical reactions. The detailed and systematic study of supramolecular photochemical systems is not very common. The dissertation research described here was designed to help fill this deficit. beta-cyclodextrin (beta-CD) is an example of a host molecule which has been used as a host to photochemical reactions. An important influence on the outcome of the solid state reaction is the surrounding crystalline environment. Structural studies of beta-CD inclusion complexes with derivatized biphenyl molecules, biphenyl and p-amino-p '-nitrobiphenyl, characterize the beta-CD dimer environment as non-constraining. Both molecules exhibit twisted conformations within the beta-CD dimer, identical to their conformations displayed in the gas phase. The photodimerization of various coumarins in crystalline beta-CD complexes was studied in detail. The beta-CD/coumarin complex was found to be a 2:3 host:guest (H:G) complex in contradiction to previous literature reports. The beta-CD dimers stack in long channels with the coumarin molecules stacked one on top of another inside creating a reaction nano-tube in which the theoretical yield is limited to 67%. The photodimerization of 7-hydroxy-4-methylcoumarin in its crystalline beta-CD inclusion complex was directly observed by X-ray diffraction. Examination of the structure of an unreacted crystal and one that was irradiated for 6 days revealed that the reaction proceeds in a topochemical fashion within the beta-CD dimer cavity. The beta-CD dimers arrange in a manner which creates isolated reaction nano-vessels throughout the crystal. The structure of the beta-CD/7-hydroxycoumarin complex shows that this complex is nearly identical the beta-CD/7-hydroxy-4-methylcoumarin complex despite the looser spatial fit of the guest to the cavity. The studies of the beta-CD/4,7-dimethylcoumarin complex produced

  3. The effects of beta-carotene and vitamin E on erythrocytes lipid peroxidation in beta-thalassemia patients

    Directory of Open Access Journals (Sweden)

    Soleiman Mahjoub

    2007-12-01

    Full Text Available BACKGROUND: Thalassemia is the most common hereditary disease in the world. Thalassemic erythrocytes are exposed to higher oxidative stress and lipid peroxidation. The aim of this study was to investigate the effects of beta-carotene and vitamin E on erythrocytes lipid peroxidation in beta-thalassemia patients.
    METHODS: A prospective double-blind, placebo-controlled study of the effect of beta-carotene and vitamin E on lipid peroxidation in erythrocytes membranes was performed on 120 beta-thalassemia major patients in four groups. The patients were supplemented for 4 weeks as follows: group 1 with beta-carotene (13 mg/day, group 2 with vitamin E (550 mg/day, group 3 with beta-carotene plus vitamin E and group 4 with placebo. We prepared all capsules for 4 roups in the same shape and color. Measurements of serum beta-carotene and vitamin E were performed by high performance
    liquid chromatography. After preparation of ghost cells from blood specimens, malondialdehyde (MDA was determined as index of lipid peroxidation in erythrocytes membranes before and after treatment. RESULTS: The levels of serum beta-carotene and vitamin E were significantly lower and MDA concentrations in erythrocytes membranes were significantly higher in beta-thalassemia patients compared to controls (P<0.001. In groups that treated with vitamin supplements for 4-weeks, lipid peroxidation rates were significantly reduced after treatment (P<0.001, but in placebo group there was not significant difference (P>0.05.
    CONCLUSIONS: Our findings provide evidence that an oral treatment with beta-carotene and vitamin E can significantly reduce lipid peroxidation of erythrocytes membranes and could be useful in management of beta-thalassemia major patients. KEYWORDS: Beta-thalassemia major, beta-carotene, vitamin E, malondialdehyde, lipid peroxidation.

  4. Developmental expression patterns of Beta-ig (betaIG-H3) and its function as a cell adhesion protein.

    Science.gov (United States)

    Ferguson, Jill W; Mikesh, Michelle F; Wheeler, Esther F; LeBaron, Richard G

    2003-08-01

    Beta-ig is a secretory protein embodied by fasciclin I-like repeats containing sequences that might bind integrins and glycosaminoglycans in vivo. Expression of Beta-ig is responsive to Transforming Growth Factor-beta and the protein is found to be associated with extracellular matrix (ECM) molecules, implicating Beta-ig as an ECM adhesive protein of developmental processes. The spatiotemporal distribution of Beta-ig during various stages of murine development was examined and its ability to support adhesion of various cell types assessed. In situ hybridization of mouse embryos (E12.5-E18.5) indicated a prominent, distinct expression pattern for Beta-ig message in connective tissue. Beta-ig transcripts were abundantly expressed during mesenchymal cell condensation in areas of axial, craniofacial and appendicular primordial cartilage from E12.5-E14.5. Beginning at E15.5, Beta-ig transcripts appeared in collagen-rich tissues, including dura mater and corneal stroma. During E16.5-E18.5, Beta-ig transcripts were observed in proliferating chondrocytes and areas of endochondral ossification in joint and articular cartilage formation. Connective tissues expressed Beta-ig transcripts within the nasal septum and surrounding cartilage primordia, and in the pericardium, optic cup, kidney, ovary, esophagus, diaphragm, bronchi, trachea and corneal epithelium, and during cardiac valve formation. These patterns of expression indicate that Beta-ig may be involved in tissue morphogenesis. Cells derived from mesenchyme attached onto a substratum comprised of purified recombinant Beta-ig. Taken together, the results indicate that Beta-ig is expressed principally in collagen-rich tissues where it may interact with cells and ECM molecules, perhaps playing a role in tissue morphogenesis.

  5. Beta blockade and physical training in rats.

    Science.gov (United States)

    Harri, M

    1982-01-01

    Beta adrenergic blocking agents are widely used in the treatment of hypertension. Recent findings indicate that long-term physical training also could reduce elevated blood pressure and many physicians therefore recommend their patients to include physical training in their everyday program. However, it is not known whether a combination of beta blockade and physical training influences the responses of an organism to physical training. This problem was investigated using laboratory rats as an experimental animal model. Both swimming and running training were used, and a group of animals was trained without any medication while the other group performed their daily training session under the influence of 10 mg/kg of propranolol. Some of the effects produced by swimming training, such as hypertrophy of brown adipose tissue and heart muscle, resting bradycardia, increased tachycardic and tail skin temperature responses to isoprenaline, increased calorigenic response to noradrenaline and delayed cooling rate in cold water were similar to those produced by cold acclimation or repeated noradrenaline injections. It is thus tempting to conclude that the training-induced release of noradrenaline was responsible for the changes mentioned. Propranolol, when associated with the training, effectively hampered these changes. Running training increased the activity of oxidative enzymes in the skeletal muscle much more than did swimming training or repeated noradrenaline injections. Furthermore, running training neither induced hypertrophy of the brown fat nor enhanced calorigenic response to noradrenaline; it even led to enhanced rate of body cooling in cold water. Therefore the adaptive changes caused by running training most probably are not due to cold acclimation effects in spite of that propranolol, when associated with the running sessions, antagonized the development of running-induced changes, too. Some of these changes, such as cardiomegaly, training bradycardia and

  6. Effects of the beta2-agonist clenbuterol on beta1- and beta2-adrenoceptor mRNA expressions of rat skeletal and left ventricle muscles.

    Science.gov (United States)

    Sato, Shogo; Nomura, Sachiko; Kawano, Fuuun; Tanihata, Jun; Tachiyashiki, Kaoru; Imaizumi, Kazuhiko

    2008-08-01

    The beta2-agonist clenbuterol [4-amino-alpha(t-butyl-amino)methyl-3,5-dichlorobenzyl alcohol] is used as a non-steroidal anabolic drug for sports doping. The effects of clenbuterol on the transcriptional process and mRNA stability of beta-adrenoceptor (beta-AR) in skeletal and cardiac muscles are still unknown. Therefore, we investigated the effects of clenbuterol on beta1- and beta2-AR mRNA expressions of fast-twitch fiber-rich extensor digitorum longus (EDL), slow-twitch fiber-rich soleus (SOL), and left ventricle (LV) muscles by real-time RT-PCR. Adult male Sprague Dawley rats were divided into the clenbuterol-administered group and control group. The administration (dose = 1.0 mg/kg body weight/day, s.c.) of clenbuterol was maintained for 10 days. The administration of clenbuterol significantly increased the weight, RNA concentration, and total RNA content of EDL muscle. No effects of clenbuterol on those of SOL and LV muscles, however, were observed. The administration of clenbuterol significantly decreased beta1-AR mRNA expression of LV muscle. Furthermore, the administration of clenbuterol significantly decreased beta2-AR mRNA expression of EDL and LV muscles. No effect of clenbuterol on beta2-AR mRNA expression of SOL muscle, however, was observed. These results suggest that the effects of clenbuterol on beta1- and beta2-AR mRNA expressions and muscle hypertrophy depend on muscle fiber types.

  7. Conversion of rice husk ash to zeolite beta.

    Science.gov (United States)

    Prasetyoko, Didik; Ramli, Zainab; Endud, Salasiah; Hamdan, Halimaton; Sulikowski, Bogdan

    2006-01-01

    White rice husk ash (RHA), an agriculture waste containing crystalline tridymite and alpha-cristobalite, was used as a silica source for zeolite Beta synthesis. The crystallization of zeolite Beta from RHA at 150 degrees C in the presence of tetraethylammonium hydroxide was monitored by XRD, FTIR and (29)Si MAS NMR techniques. It was found that zeolite Beta started to form after 12h and the complete crystallization of zeolite Beta phase was achieved after 2d. XRD, (29)Si MAS NMR and solid yield studies indicate that the transformation mechanism of silica present in RHA to zeolite Beta involves dissolution of the ash, formation of an amorphous aluminosilicate after 6h of crystallization, followed by dissolution in the mother liquor and final transformation to pure zeolite Beta crystals.

  8. The BetaCage: Ultrasensitive Screener for Radioactive Backgrounds

    Science.gov (United States)

    Thompson, Michael; BetaCage Collaboration

    2017-09-01

    Rare event searches, such as dark matter detection and neutrinoless double beta decay, require screening of materials for backgrounds such as beta emission and alpha decaying isotopes. The BetaCage is a proposed ultra-sensitive time-projection chamber to screen for alpha-emitting and low energy beta-emitting (10-200 keV) contaminants. The expected sensitivity is 0.1 beta particles (perkeV -m2 - day) and 0.1 alpha particles (perm2 - day) , where the former will be limited by Compton scattering of external photons in the screening samples and the latter is expected to be signal-limited. The prototype BetaCage under commissioning at South Dakota School of Mines & Technology is filled with P10 gas (10% methane, 90% argon) in place of neon and is 40×40×20 cm in size. Details on design, construction and characterization will be presented.

  9. [Preparation of alpha-hydrocycholic-beta-cyclodextrin inclusion compound].

    Science.gov (United States)

    Bian, Yan-hong; Zhang, Dan-yan; Xiong, Qing-ping

    2007-11-01

    To study the preparation of alpha-Hydrocycholic-beta-Cyclodextrin inclusion compound. It was studied with orthogonal design to analysis three factors of inclusion rate such as the weight ratio between HDCA and beta-Cyclodextrin, the temperature and the reaction time. Fourier transform infrared spectroscopy, scanning electron microscopy, taste and solubility test were used to identify the inclusion compound. Stable inclusion compound was made by HDCA and beta-Cyclodextrin. The weight ratio between HDCA and beta-Cyclodextrin was the most important factor. The alpha-Hydrocycholic-beta-Cyclodextrin inclusion compound taste and the solubility were improved. The optimum preparation condition is alpha-Hydrocycholic : beta-Cyclodextrin = 8.67 : 1, the inclusion temperature is 60 degrees C and the inclusion time is 30 minutes.

  10. Dopaminergic and beta-adrenergic effects on gastric antral motility

    DEFF Research Database (Denmark)

    Bech, K; Hovendal, C P; Gottrup, F

    1984-01-01

    of bethanechol or pentagastrin inducing motor activity patterns as in the phase III of the MMC and the digestive state respectively. The stimulated antral motility was dose-dependently inhibited by dopamine. The effect was significantly blocked by specifically acting dopaminergic blockers, while alpha- and beta......-adrenergic blockers were without any significant effects. Dose-response experiments with bethanechol and dopamine showed inhibition of a non-competitive type. Isoprenaline was used alone and in conjunction with selective blockade of beta 1- and beta 2-receptors during infusion of bethanechol which induces a pattern...... similar to phase III in the migrating myoelectric complex. The stimulated antral motility was dose-dependently inhibited by isoprenaline. The effect could be significantly blocked by propranolol (beta 1 + beta 2-adrenoceptor blocker) and by using in conjunction the beta 1-adrenoceptor blocker practolol...

  11. Chemical Methods to Induce Beta-Cell Proliferation

    Directory of Open Access Journals (Sweden)

    Amedeo Vetere

    2012-01-01

    Full Text Available Pancreatic beta-cell regeneration, for example, by inducing proliferation, remains an important goal in developing effective treatments for diabetes. However, beta cells have mainly been considered quiescent. This “static” view has recently been challenged by observations of relevant physiological conditions in which metabolic stress is compensated by an increase in beta-cell mass. Understanding the molecular mechanisms underlining these process could open the possibility of developing novel small molecules to increase beta-cell mass. Several cellular cell-cycle and signaling proteins provide attractive targets for high throughput screening, and recent advances in cell culture have enabled phenotypic screening for small molecule-induced beta-cell proliferation. We present here an overview of the current trends involving small-molecule approaches to induce beta-cell regeneration by proliferation.

  12. Purification and properties of beta-galactosidase from Aspergillus nidulans.

    Science.gov (United States)

    Díaz, M; Pedregosa, A M; de Lucas, J R; Torralba, S; Monistrol, I F; Laborda, F

    1996-12-01

    Beta-Galactosidase from mycelial extract of Aspergillus nidulans has been purified by substrate affinity chromatography and used to obtain anti-beta-galactosidase polyclonal antibodies. A. nidulans growing in lactose as carbon source synthesizes one active form of beta-galactosidase which seems to be a multimeric enzyme of 450 kDa composed of monomers with 120 and 97 kDa. Although the enzyme was not released to the culture medium, some enzymatic activity was detected in a cell-wall extract, thus suggesting that it can be an extracellular enzyme. Beta-Galactosidase of A. nidulans is a very unstable enzyme with an optimum pH value of 7.5 and an optimum temperature of 30 degrees C. It was only active against beta-galactoside substrates like lactose and p-nitrophenyl-beta-D-galactoside (PNPG).

  13. Acquired TGF beta 1 sensitivity and TGF beta 1 expression in cell lines established from a single small cell lung cancer patient during clinical progression

    DEFF Research Database (Denmark)

    Nørgaard, P; Damstrup, L; Rygaard, K

    1996-01-01

    Three small cell lung cancer cell lines established from a single patient during longitudinal follow-up were examined for in vitro expression of TGF beta and TGF beta receptors, i.e. the components of an autocrine loop. GLC 14 was established prior to treatment, GLC 16 on relapse after chemotherapy...... and GLC 19 on recurrence after radiotherapy. TGF beta was detected by ELISA and TGF beta receptors by chemical crosslinking to radiolabelled TGF beta 1. Furthermore, TGF beta and TGF beta receptor mRNAs were detected by northern blot analysis. Expression of type II TGF beta receptor mRNA and protein...

  14. Antibodies against Pseudomonas aeruginosa chromosomal beta-lactamase inpatients with cystic fibrosis are markers of the development of resistance of P. aeruginosa to beta-lactams

    DEFF Research Database (Denmark)

    Ciofu, O; Giwercman, B; Walter-Rasmussen, J

    1995-01-01

    Chromosomal beta-lactamase production is considered to be the most important resistance mechanism of Pseudomonas aeruginosa against beta-lactams. Recently we have detected serum and sputum antibodies against P. aeruginosa chromosomal beta-lactamase (a beta ab), using immunoblotting techniques...... infection and was significantly higher (P beta-lactam courses. A 14 fold increase in a beta ab...... levels occurred during the 14 year period covered by the longitudinal study. The results of this study show that a beta ab to P. aeruginosa is a specific marker for resistance development of P. aeruginosa to beta-lactams....

  15. Intracranial Extramedullary Hematopoiesis in Beta-Thalassemia

    Energy Technology Data Exchange (ETDEWEB)

    Karki, Bivek; Xu, Yi Kai; Wu, Yuan Kui [Nan fang Hospital, Southern Medical University, Guangzhou (China); Tamrakar, Karuna [Zhujiang Hospital, Southern Medical University, Guangzhou (China)

    2012-03-15

    Extramedullary hematopoiesis (EMH) represents tumor-like proliferation of hemopoietic tissue which complicates chronic hemoglobinopathy. Intracranial EMH is an extremely rare occurrence. Magnetic resonance imaging (MRI) offers a precise diagnosis. It is essential to distinguish EMH from other extradural central nervous system tumors, because treatment and prognosis are totally different. Herein, we report the imaging findings of beta-thalassemia in a 13-year-old boy complaining of weakness of left side of the body and gait disturbance; CT and MRI revealed an extradural mass in the right temporoparietal region.

  16. The high sensitivity double beta spectrometer TGV

    Science.gov (United States)

    Briancon, Ch.; Brudanin, V. B.; Egorov, V. G.; Janout, Z.; Koníček, J.; Kovalík, A.; Kovalenko, V. E.; Kubašta, J.; Pospíšil, S.; Revenko, A. V.; Rukhadze, N. I.; Salamatin, A. V.; Sandukovsky, V. G.; Štekl, I.; Timkin, V. V.; Tsupko-Sitnikov, V. V.; Vorobel, V.; Vylov, Ts.

    1996-02-01

    A high sensitivity double beta spectrometer TGV (Telescope Germanium Vertical) has been developed. It is based on 16 HPGe detectors of volume 1200 × 6 mm 3 each in the same cryostat. The TGV spectrometer was proposed for the study of ultrarare nuclear processes (e.g. 2νββ, 0νββ, 2νEC/EC). Details of the TGV spectrometer construction are described, the principles of background suppression, the results of Monte Carlo simulations and the results of test background measurements (in Dubna and Modane underground laboratory) are provided.

  17. Update on beta-lactam allergy diagnosis.

    Science.gov (United States)

    Demoly, Pascal; Romano, Antonino

    2005-01-01

    Allergic reactions to penicillin and cephalosporin antibiotics are common. The mechanisms involved are heterogeneous and not yet completely understood. However, clinical and immunologic studies suggest that type I (IgE-mediated) and type IV (cell-mediated) pathogenic mechanisms are involved in most immediate and non-immediate reactions, respectively. The diagnostic procedure has recently been standardized under the aegis of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interest group on drug hypersensitivity. In this review, we describe the general guidelines for evaluating subjects in whom there is suspicion of allergic reactions to beta-lactams.

  18. Improved Synthesis Of Potassium Beta' '-Alumina

    Science.gov (United States)

    Williams, Roger M.; Jeffries-Nakamura, Barbara; Ryan, Margaret A.; O'Connor, Dennis E.; Kisor, Adam; Underwood, Mark

    1996-01-01

    Improved formulations of precursor materials synthesize nearly-phase-pure potassium beta' '-alumina solid electrolyte (K-BASE) powder. Materials are microhomogeneous powders (or, alternatively, gels) containing K(+,) Mg(2+), and Al(3+). K-BASE powder produced used in potassium-working-fluid alkali-metal thermal-to-electric conversion (K-AMTEC), in which heat-input and heat-rejection temperatures lower than sodium-working-fluid AMTEC (Na-AMTEC). Additional potential use lies in purification of pottassium by removal of sodium and calcium.

  19. Time-interval analysis of beta decay

    Science.gov (United States)

    Horvat, V.; Hardy, J. C.

    2013-06-01

    A time-interval method of beta-decay half-life analysis is described. The method is expected to produce results that are highly accurate (for the given number of events analyzed), regardless of the event rate, nature of the detection-system dead time, and/or extent of the dead time. This was verified by applying the method in a systematic way to an array of simulated data sets characterized by typical as well as extreme combinations of simulation parameters. The results of the analysis are presented and discussed.

  20. Tiempo para un cambio

    Science.gov (United States)

    Woltjer, L.

    1987-06-01

    En la reunion celebrada en diciembre dei ano pasado informe al Consejo de mi deseo de terminar mi contrato como Director General de la ESO una vez que fuera aprobado el proyecto dei VLT, que se espera sucedera hacia fines de este aAo. Cuando fue renovada mi designacion hace tres aAos, el Consejo conocia mi intencion de no completar los cinco aAos dei contrato debido a mi deseo de disponer de mas tiempo para otras actividades. Ahora, una vez terminada la fase preparatoria para el VLT, Y habiendose presentado el proyecto formalmente al Consejo el dia 31 de marzo, y esperando su muy probable aprobacion antes dei termino de este ano, me parece que el 10 de enero de 1988 presenta una excelente fecha para que se produzca un cambio en la administracion de la ESO.

  1. Study of lactose / $\\beta$-lactoglobulin interactions during storage

    OpenAIRE

    Thomas, Marie; Scher, Joël; Desobry, Stéphane

    2005-01-01

    International audience; The objective of this study was to evaluate the interactions between lactose and $\\beta$-lactoglobulin in $\\beta$-lactoglobulin/lactose powders (BL powders) during storage. Model BL powders were produced by co-lyophilization of lactose with increasing quantities of $\\beta$-lactoglobulin. Lyophilization produced lactose in the amorphous state, which is highly reactive and likely leads to agglomeration of industrial whey powders. The BL powders were stored at 20 ± 1 °C f...

  2. Alpha/beta separation in liquid scintillation gel samples

    Energy Technology Data Exchange (ETDEWEB)

    Grau Carles, A. (Instituto de Investigacion Basica, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Avda. Complutense 22, 28040 Madrid (Spain)); Grau Malonda, A. (Instituto de Investigacion Basica, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Avda. Complutense 22, 28040 Madrid (Spain))

    1994-06-01

    The pulse shape analysis commonly used in liquid scintillation alpha/beta separations is satisfactory for moderate quench levels. However, for gel samples, the alpha particle counting efficiency is never greater than 10%, and an optimum separation of the alpha component cannot be achieved when beta to alpha counting rate ratios are greater than 100. In such cases, it is better to use a spectrum analysis method for alpha/beta separation. ((orig.))

  3. Proceedings of the Department of Energy workshop on beta measurements

    Energy Technology Data Exchange (ETDEWEB)

    Swinth, K.L.; Vallario, E.J.

    1987-09-01

    Participants discussed current practices, efforts to upgrade the quality of beta measurements, and initiatives necessary to improve the measurement and control of beta doses. This proceedings includes papers presented at the workshop, transcripts of panel and open discussions, and documentation of question and answer sessions. The information exchange resulting from this meeting is expected to provide a clearer focus on the problems of beta measurements.

  4. Solute effects on deformation and fracture of beta brass

    Science.gov (United States)

    Shea, M. M.; Stoloff, N. S.

    1973-01-01

    It is shown that the ductility of several ternary beta brass alloys in air and in several liquid metals can be related to the operative slip and grain boundary relaxation processes. Nickel and manganese were chosen as alloying elements because they are expected to respectively enhance and suppress cross slip in beta brass. Single-phase binary and ternary beta brass alloys were used in both polycrystalline and single crystal form.

  5. Performance of the drift chamber beta-ray momentum analyzer for double beta decay experiments

    Science.gov (United States)

    Ishihara, N.; Ohama, T.; Yamada, Y.; Kato, Y.; Inagaki, T.; Iwai, G.; Iwase, H.; Kawai, M.; Kondou, Y.; Makida, Y.; Takahashi, K.; Ujiie, N.; Tanaka, K.; Tonooka, M.; Hamatsu, R.; Ishikawa, T.; Igarashi, H.; Ito, T.; Kakizaki, M.; Kakuno, H.; Kitamura, S.; Sumiyoshi, T.; Yoshioka, T.; Ishizuka, T.; Tamura, N.; Sakamoto, Y.; Nagasaka, Y.; Ito, R.

    2017-07-01

    One of the most important problems in neutrino physics is whether neutrinos are Majorana particles or Dirac ones. If a neutrino has a Majorana nature, neutrinoless double beta decay (0ν2β) certainly takes place. On the other hand, there is a theory in which neutrinoless quadruple beta decay (0ν4β) is possible, allowing for lepton number violation by four units, even if a neutrino has a Dirac nature. Since the half-lives of both 0ν2β and 0ν4β are theoretically expected to be very long, detectors have to have an excellent capability to eliminate backgrounds. We have been developing a series of electron momentum analyzers called the drift chamber beta-ray analyzer (DCBA) at KEK for double beta decay experiments. DCBA consists of drift chambers detecting charged particle tracks, and a superconducting solenoid serving a uniform magnetic field. Since the momentum acceptance is in the region of 0.5-3.5 MeV/c, it is easy to eliminate background particles like alpha particles, protons, and muons, which have much higher momenta because of their large masses. The particle identification property and the 3D position determination capability are powerful tools to search for 0ν2β and 0ν4β events. In this article, we describe the performance of DCBA as well as the details of the detector construction processes.

  6. On the absolute measure of Beta activities; Sobre la medida absoluta de actividades Beta

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez del Rio, C.; Jimenez Reynaldo, O.; Rodriguez Mayquez, E.

    1956-07-01

    A new method for absolute beta counting of solid samples is given. The measurements is made with an inside Geiger-Muller tube of new construction. The backscattering correction when using an infinite thick mounting is discussed and results for different materials given. (Author)

  7. Sizeable beta-strength in 31Ar (beta 3p) decay

    DEFF Research Database (Denmark)

    T. Koldste, G.; Blank, B.; J. G. Borge, M.

    2014-01-01

    We present for the first time precise spectroscopic information on the recently discovered decay mode beta-delayed 3p-emission. The detection of the 3p events gives an increased sensitivity to the high energy part of the Gamow-Teller strength distribution from the decay of 31Ar revealing that as ...

  8. Neuroinflammation and Complexes of 17 beta-Hydroxysteroid Dehydrogenase type 10-Amyloid beta in Alzheimer's Disease

    Czech Academy of Sciences Publication Activity Database

    Krištofíková, Z.; Řípová, D.; Bartoš, A.; Bocková, Markéta; Hegnerová, Kateřina; Říčný, J.; Čechová, L.; Vrajová, M.; Homola, Jiří

    2013-01-01

    Roč. 10, č. 2 (2013), s. 165-173 ISSN 1567-2050 R&D Projects: GA MZd(CZ) NT11225 Institutional support: RVO:67985882 Keywords : Amyloid beta * mitochondrial enzyme * Alzheimer's disease Subject RIV: JB - Sensors, Measurment, Regulation Impact factor: 3.796, year: 2013

  9. Noncovalent Interaction Energies in Covalent Complexes: TEM-1 beta-Lactamase and beta-Lactams

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xiaojun; Minasov, George; Shoichet, Brian K. (NWU)

    2010-03-08

    The class A {beta}-lactamase TEM-1 is a key bacterial resistance enzyme against {beta}-lactam antibiotics, but little is known about the energetic bases for complementarity between TEM-1 and its inhibitors. Most inhibitors form a covalent adduct with the catalytic Ser70, making the measurement of equilibriumconstants, and hence interaction energies, technically difficult. This study evaluates noncovalent interactions withincovalent complexes by examining the differential stability of TEM-1 and its inhibitor adducts. The thermal denaturation of TEM-1 follows a two-state, reversible model with a melting temperature (T{sub m}) of 51.6 C and a van't Hoff enthalpy of unfolding ({Delta}H{sub VH}) of 146.2 kcal/mol at pH 7.0. The stability of the enzyme changes on forming an inhibitor adduct. As expected, some inhibitors stabilize TEM-1; transition-state analogues increase the T{sub m} by up to 3.7 C(1.7 kcal/mol). Surprisingly, all {beta}-lactam covalent acyl-enzyme complexes tested destabilize TEM-1 significantly relative to the apoenzyme. For instance, the clinically used inhibitor clavulanic acid and the {beta}-lactamase-resistant {beta}-lactams moxalactam and imipenem destabilize TEM-1 by over 2.6 C (1.2 kcal/mol) in their covalent adducts. Based on the structure of the TEM-1/imipenem complex (Maveyraud et al., J Am Chem Soc 1998;120:9748-52), destabilization by moxalactam and imipenem is thought to be caused by a steric clash between the side-chain of Asn132 and the 6(7)-{alpha} group of these {beta}-lactams. To test this hypothesis, the mutant enzyme N132A was made. In contrast with wild-type, the covalent complexes between N132A and both imipenem and moxalactam stabilize the enzyme, consistent with the hypothesis. To investigate the structural bases of this dramatic change instability, the structure of N132A/imipenem was determined by X-ray crystallography. In the complex with N132A, imipenemadopts a very different conformation from that observed in the wild

  10. Instrucciones para autores

    OpenAIRE

    Juan Carreño Cardozo

    2015-01-01

    Instrucciones para autoresNota preliminar: ¡Es de suma importancia que antesde enviar cualquier documento a la Revista GeologíaColombiana, lea y cumpla cuidadosamente cada uno delos subíndices de las Normas para autores!A partir del Volumen 35 (2010) recibimos artículosprincipalmente a través del sistema digital enhttp://www.revistas.unal.edu.co/index.php/geocol/index.Si quiere enviar un artículo, por favor regístrese comoAutor en el menú INGRESAR (aquí pueden registrarsetambién evaluadores u...

  11. Control interno para MIPYMES

    OpenAIRE

    Becerra Pineda, Cindy Johana; Salgado Vera, Ginna Paola

    2014-01-01

    El objetivo general del presente trabajo es proponer un modelo que ayude a detectar y mitigar los riesgos a los que están expuestas las micro, pequeñas y medianas empresas y así contribuir a asegurar un adecuado desarrollo operacional en las MIPYMES, para lo cual se planteó la elaboración de un modelo para estructurar el control interno en estas empresas. El trabajo se desarrolló en cuatro capítulos: el primero introduce al control interno, indicando la importancia dentro de un negocio; el se...

  12. Master Plan para UNIMAK

    OpenAIRE

    Llorente Moreno, Francisco; Navarrete Mancebo, Gonzalo; Cruz Pinilla, Javier de la; García Méndez, María; Lacastagneratte de Figueiredo, Laura

    2012-01-01

    El Master Plan de UNIMAK se presenta como una apuesta a futuro, no solo para la Universidad de Makeni, sino también para la propia ciudad de Makeni. Se pretende potencias la Universidad como una referencia a nivel regional y como desencadenante de la estructura de trazado de la ciudad. El proyecto plantea potencial la dualidad que existe entre la infraestructura viaria y la red verde , existente en la ciudad, introduciéndola en el nuevo desarrollo del campus universitario y dotándola de la i...

  13. Combinatoria para la escuela

    OpenAIRE

    Sarmiento, Benjamín; Fernández, Felipe

    2014-01-01

    Con este cursillo se pretende mostrar a los asistentes que el análisis combinatorio no es una temática exclusiva para los que se inician en el estudio de las probabilidades y que no se requiere llegar a ese nivel, para empezar a conocer los principios combinatorios y las reglas básicas de esta rama. Por eso se ha seleccionado un conjunto de problemas y situaciones que se puedan llevar a la escuela. A lo largo del cursillo se propondrán situaciones clásicas relacionadas con los principios y re...

  14. Isolation and characterization of chicken and turkey beta 2-microglobulin

    DEFF Research Database (Denmark)

    Skjødt, K; Welinder, K G; Crone, M

    1986-01-01

    Chicken and turkey beta 2-m were isolated from citrated plasma in sequential use of three chromatographic steps: affinity chromatography, gel filtration chromatography and anion-exchange chromatography. The purified protein was identified as beta 2-m by reaction with a beta 2-m specific monoclonal...... antibody and by the ability to recombine with the chicken MHC class I heavy chain. The purity was estimated by SDS-PAGE and IEF. The pI was between 5.1 and 5.3 for chicken beta 2-m and 4.7 and 4.8 for turkey beta 2-m, which fact is reflected in their different electrophoretic mobilities in agarose gel...... (turkey migrates in the alpha and chicken migrates in the beta region). The mol. wt of both chicken and turkey beta 2-m was 14,500 estimated by SDS-PAGE whereas calculations based on the amino acid compositions gave mol. wts of 11,000. EM280 was 15.9 for chicken beta 2-m and 16.4 for turkey beta 2-m...

  15. Utilization of Beta blockers post-myocardial infarction.

    Science.gov (United States)

    Ong, W M; Che Zuraini, S; Wan Azman, W A; Rajasuriar, R

    2013-01-01

    Beta blockers provide both morbidity and mortality benefits for post-myocardial infarction (MI) patients. Despite this, beta blockers are still often underused or used at suboptimal dosages. This was a retrospective observational study with the objectives of estimating the proportion of post-MI patients who are receiving beta-blocker therapy in University Malaya Medical Centre (UMMC), assessing the number of them receiving beta blockers at optimal dosages and determining the factors associated with beta-blocker prescribing post-MI. Of 315 patient case notes reviewed, 77.5% were prescribed beta blockers. However, dosages were optimized in only 39.3% of patients. Reasons for not optimizing the dosages were typically not due to the presence of contraindications to beta blockers. Elderly (> 65 years old), ejection fraction (EF) digoxin or anti-asthmatic agents were all significantly associated with a reduced rate of beta-blocker prescribing post-MI. More effort should be placed in improving its use in specific patient populations. Initiatives to optimize the dosage of beta blockers to recommended dosages that matched those in clinical trials with proven mortality benefits will also need to be intensified.

  16. Interleukin-1 beta targeted therapy for type 2 diabetes

    DEFF Research Database (Denmark)

    Maedler, K.; Dharmadhikari, G.; Schumann, D.M.

    2009-01-01

    Since having been cloned in 1984, IL-1beta has been the subject of over 22,000 citations in Pubmed, among them over 800 reviews. This is because of its numerous effects. IL-1beta is a regulator of the body's inflammatory response and is produced after infection, injury, and antigenic challenge....... Macrophage-derived IL-1beta production in insulin-sensitive organs, leads to progression of inflammation and induction of insulin resistance in obesity. We summarize the mechanisms involved in inflammation and specifically the IL-1beta signals that lead to the progression of insulin resistance and diabetes...

  17. The aCORN backscatter-suppressed beta spectrometer

    Science.gov (United States)

    Hassan, M. T.; Bateman, F.; Collett, B.; Darius, G.; DeAngelis, C.; Dewey, M. S.; Jones, G. L.; Komives, A.; Laptev, A.; Mendenhall, M. P.; Nico, J. S.; Noid, G.; Stephenson, E. J.; Stern, I.; Trull, C.; Wietfeldt, F. E.

    2017-09-01

    Backscatter of electrons from a beta detector, with incomplete energy deposition, can lead to undesirable effects in many types of experiments. We present and discuss the design and operation of a backscatter-suppressed beta spectrometer that was developed as part of a program to measure the electron-antineutrino correlation coefficient in neutron beta decay (aCORN). An array of backscatter veto detectors surrounds a plastic scintillator beta energy detector. The spectrometer contains an axial magnetic field gradient, so electrons are efficiently admitted but have a low probability for escaping back through the entrance after backscattering. The design, construction, calibration, and performance of the spectrometer are discussed.

  18. Chlamydia pneumoniae Promotes Dysfunction of Pancreatic Beta Cells

    Science.gov (United States)

    Rodriguez, Annette R.; Plascencia-Villa, Germán; Witt, Colleen M.; Yu, Jieh-Juen; José-Yacamán, Miguel; Chambers, James P.; Perry, George; Guentzel, M. Neal; Arulanandam, Bernard P.

    2015-01-01

    The human pathogen Chlamydia pneumoniae has been implicated in chronic inflammatory diseases including type 2 diabetes. Therefore, we designed a study to evaluate pancreatic beta cells and mast cells during chlamydial infection. Our study revealed that C. pneumoniae infected mast cells significantly (ppneumoniae infected mice showed increased interleukin-1β production in splenocytes and pancreatic tissues as was observed with in vitro mast cell-beta cell co-cultures during C. pneumoniae infection. Notably, infected mast cells promoted beta cell destruction. Our findings reveal the negative effect of C. pneumoniae on mast cells, and the consequential impact on pancreatic beta cell function and viability. PMID:25863744

  19. beta-1,3-glucan modifying enzymes in Aspergillus fumigatus

    Directory of Open Access Journals (Sweden)

    Isabelle eMouyna

    2013-04-01

    Full Text Available In Aspergillus fumigatus like in other filamentous ascomycetes, beta-1,3-glucan constitutes a prominent cell wall component being responsible for rigidity of the cell wall structure. In filamentous fungi, softening of the cell wall is absolutely required during conidial germination and hyphal branching. Because of the central structure of beta(1-3glucans, it is expected that beta-1,3-glucanases play a major role in cell wall softening. Based on in silico and experimental data, this review gives an overview of beta-1,3-glucan modifying enzyme in A. fumigatus genome and their putative role during morphogenesis.

  20. Use of an anthropomorphic hand phantom to verify the radiation intensity that is needed to modify the analog and digital radiographic quality; Uso de um fantoma antropomorfo de mao para verificar a intensidade da radiacao que e necessaria para modificar a qualidade da radiografia analogica e a digital

    Energy Technology Data Exchange (ETDEWEB)

    Bandeira, Caroline K.; Vieira, Michele P.M.M., E-mail: kretezel@hotmail.com, E-mail: michele.vieira@ifpr.edu.br [Instituto Federal do Parana (IFPR), Curitiba, PR (Brazil); Felix, Jose E.R., E-mail: felix@anomati.net [Universidade Federal do Triangulo Mineiro (UFTM), Uberaba, MG (Brazil)

    2014-07-01

    The radiology is a field of medicine that is in constantly expansion and advancing. This can be noticed with the transition from analog to digital radiology systems, it is important that professionals understand image formation in both systems in order to produce radiographies with diagnostic quality. Therefore, the objective of this work is to present the importance of radiological protection by changing values of technical parameters while the quality of radiographic imaging is sustained. An anthropomorphic hand phantom was built in order to obtain radiographies, as it is necessary to respect the Brazilian regulations (Portaria 453/98) which forbids the use of radiation in patients for testing. Three analog and eight digital radiographies were obtained using fixed kVp and varying mAs. Each image was compared to the others acquired in the same location. Digital radiographies have shown that approximately 28% of change in mAs is necessary to change noise, whereas approximately 33,3% is necessary in the analog system to change density. The conclusion is that computerized systems need less x-ray intensity to modify image features and can reduce the patient radiation doses. However, more testing must be conducted in different radiologic environments to confirm the results obtained in the present study. (author)

  1. Pterygia: Single-fraction postoperative beta irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Beyer, D.C. (Radiation Oncologists of Central Arizona, Phoenix (USA))

    1991-02-01

    A retrospective evaluation was performed with records of 128 patients with 146 eyes that underwent applications of strontium-90 after pterygium excisions performed between 1982 and 1988. With a median follow-up of 13 months, 135 eyes were evaluable. Most pterygia (127 of 135) were treated with a single postoperative application of Sr-90 that delivered 3,000 cGy of beta radiation in one fraction. The actuarial freedom from relapse was 87%; all recurrences occurred within the first 18 months, and 46% of these within the first 3 months. Of the 13 recurrences, 10 have been re-treated with surgery and a second course of beta irradiation with excellent results. All eight eyes for which follow-up was available had no evidence of disease. The ultimate control rate was 96.3% for the series. Correlation of various treatment parameters, including age, bilaterality, prior recurrence, and interval from surgery to irradiation, was performed, and no statistically significant difference was seen. No serious complications have developed. Transient conjunctivitis and photophobia were almost universally seen, with five cases lasting beyond 5 months. The authors conclude that a single application of Sr-90 after surgery is effective and safe in managing pterygia.

  2. Neutrinoless double beta decay search with SNO+

    Directory of Open Access Journals (Sweden)

    Lozza V.

    2014-01-01

    Full Text Available The SNO+ experiment is the follow up of SNO. The detector is located 2 km underground in the Vale Canada Ltd.’s Creighton Mine near Sudbury, Ontario, Canada. The active volume of the detector consists of 780 tonnes of Linear Alkyl Benzene (LAB in an acrylic vessel of 12 m diameter, surrounded by about 9500 PMTs. The main goal of the SNO+ experiment is the search for neutrinoless double beta decay of 130Te. With an initial loading of 0.3% of natural tellurium (nearly 800 kg of 130Te, it is expected to reach a sensitivity on the effective Majorana neutrino mass of about 100 meV after several years of data taking. Designed as a general purpose neutrino experiment, other exciting physical goals can be explored, like the measurement of reactor neutrino oscillations and geo-neutrinos in a geologically-interesting location, watch of supernova neutrinos and studies of solar neutrinos. A first commissioning phase with water filled detector will start at the end of 2013, while the double beta decay phase will start in 2015.

  3. Neutrinoless double beta decay search with SNO+

    Science.gov (United States)

    Lozza, V.

    2014-01-01

    The SNO+ experiment is the follow up of SNO. The detector is located 2 km underground in the Vale Canada Ltd.'s Creighton Mine near Sudbury, Ontario, Canada. The active volume of the detector consists of 780 tonnes of Linear Alkyl Benzene (LAB) in an acrylic vessel of 12 m diameter, surrounded by about 9500 PMTs. The main goal of the SNO+ experiment is the search for neutrinoless double beta decay of 130Te. With an initial loading of 0.3% of natural tellurium (nearly 800 kg of 130Te), it is expected to reach a sensitivity on the effective Majorana neutrino mass of about 100 meV after several years of data taking. Designed as a general purpose neutrino experiment, other exciting physical goals can be explored, like the measurement of reactor neutrino oscillations and geo-neutrinos in a geologically-interesting location, watch of supernova neutrinos and studies of solar neutrinos. A first commissioning phase with water filled detector will start at the end of 2013, while the double beta decay phase will start in 2015.

  4. The toxicity of beta-carotene.

    Science.gov (United States)

    Heywood, R; Palmer, A K; Gregson, R L; Hummler, H

    1985-08-01

    The safety of beta-carotene, a widely distributed food colorant was assessed in tests with cells and in sub-chronic and chronic experiments with animals. Mutagenicity evaluations which included the standard Ames test and the micro-nucleus test of bone marrow cells from mice showed that beta-carotene exerted no mutagenic properties. Embryotoxicity studies in rats and rabbits showed that there was no evidence of embryotoxicity and a multiple generation study in rats showed that there was no interference with the reproductive function in rats given oral doses of up to 1000 mg/kg/day. Chronic toxicity was studied in a 2-year study with dogs in a toxicity/tumorigenicity study in rats and in a mouse carcinogenicity study. Histological findings in the livers of treated dogs and mice, but not in rats, included vacuolated cells with eccentric nuclei which were distributed in periportal areas and which were frequently associated with minimal lipid deposition. There was no evidence that the vacuolisation was dose-related. It was considered that the vacuolated cells were fat storage cells. There was no effect on the tumor profiles in the rat and the mouse studies.

  5. Factors affecting drug adsorption on beta zeolites.

    Science.gov (United States)

    Pasti, Luisa; Sarti, Elena; Cavazzini, Alberto; Marchetti, Nicola; Dondi, Francesco; Martucci, Annalisa

    2013-05-01

    The adsorption behaviour of three commonly used drugs, namely ketoprofen, hydrochlorothiazide and atenolol, from diluted aqueous solutions on beta zeolites with different SiO2/Al2O3 ratio (i.e. 25, 38 and 360) was investigated by changing the ionic strength and the pH, before and after thermal treatment of the adsorbents. The selective adsorption of drugs was confirmed by thermogravimetry and X-ray diffraction. The adsorption capacity of beta zeolites was strongly dependent on both the solution pH and the alumina content of the adsorbent. Such a remarkable difference was interpreted as a function of the interactions between drug molecules and zeolite surface functional groups. Atenolol was readily adsorbed on the less hydrophobic zeolite, under pH conditions in which electrostatic interactions were predominant. On the other hand, ketoprofen adsorption was mainly driven by hydrophobic interactions. For undissociated molecules the adsorption capability increased with the increase of hydrophobicity. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Dosagem de interleucina 1beta na doença periodontal Concentration of interleukine 1beta in periodontal disease

    Directory of Open Access Journals (Sweden)

    Gastão Valle Nicolau

    2003-03-01

    Full Text Available Determinar o papel da interleucina - 1beta (IL-1beta como mediador das reações inflamatórias e imunitárias na doença periodontal. FORMA DE ESTUDO: Clínico prospectivo. MATERIAL E MÉTODO: Determinação da concentração da IL-1beta no grupo I (20 indivíduos sadios e no grupo II (20 indivíduos com doença periodontal, empregando o Kit Easia (Medgenix IL-1beta, com resultados analisados pelo teste t de Student. RESULTADOS: No grupo controle, os valores da IL-1beta foram de 71,28 ± 280,05 pg/ml, e na doença periodontal de 3618,49 ± 2864,75 pg/ml. CONCLUSÃO: A dosagem do IL1-beta no fluido gengival é acentuadamente maior que na doença periodontal.Determine the role of interleukine - 1beta (IL-1beta as intercellular mediator in generation, amplification and maintenance of inflammatory and immune responses in periodontal disease. STUDY DESIGN: Clinical prospective. MATERIAL AND METHOD: Assessment of concentration of 1L-1beta in group I (20 samples of healthy people and in group II (20 samples of patients with periodontal disease, employing Easia Kit (Medgenix 1L-1beta, with results statistically analyzed through Student t Test. RESULTS: In control group, media and standard deviation of 1L-1beta concentration were 71,28 ± 280,05 pg/ml and in periodontal disease 3618,49 ± 2864,75 pg/ml. CONCLUSION: The increase of Interleucine 1beta in periodontal disease distinguish from healthy oral mucosa.

  7. Is Hb A2 elevated in adults with sickle-alpha-thalassemia (beta(S)/beta(S); -alpha/-alpha)?

    Science.gov (United States)

    Ballas, S K; Gay, R N; Chehab, F F

    1997-09-01

    Thirteen patients with sickle cell anemia (SS) were found to have two alpha gene deletions with a presumptive genotype of beta(S)/beta(S); -alpha/-alpha. Hematological data showed that this group of patients had elevated Hb A2 level. In order to determine whether the elevation of Hb A2 is typical of SS with a two alpha gene deletion or is due to undiagnosed S-beta(O)-thalassemia with a two alpha gene deletion we looked for the presence or absence of beta(O)-thalassemia by molecular techniques. The latter included reverse dot-blot hybridization to rule out a beta-thalassemia mutation, digestion with CvnI endonuclease followed by Southern blotting and hybridization with a beta genomic probe, and, in selected patients, determination of the synthetic alpha/beta ratio. One of the 13 patients had S-beta(O)-thalassemia with a G-->A mutation at IVS-II-1 indicating that her genotype was beta(S)/beta(O) thalassemia; -alpha/-alpha. The remaining 12 patients were homozygous for the sickle gene, had relatively elevated Hb levels, increased Hb A2 values, and Hb F levels similar to those in patients with SS and four or three alpha genes. At the clinical level, the 12 patients with SS and a two alpha gene deletion had increased prevalence of avascular necrosis, retinopathy, and splenomegaly, but decreased prevalence of leg ulcers and cerebrovascular accidents. Together, the data indicate that SS with a two alpha gene deletion (beta(S)/beta(S); -alpha/-alpha) is a unique subset of patients with SS characterised by distinct hematological and clinical features.

  8. Expression of BK Ca channels and the modulatory beta-subunits in the rat and porcine trigeminal ganglion

    DEFF Research Database (Denmark)

    Johansson, Helle Wulf; Hay-Schmidt, Anders; Poulsen, Asser Nyander

    2009-01-01

    (Ca) channel protein was visualized by western blotting and histochemistry. The presence of the modulatory beta1-beta 4 subunit mRNAs was investigated using RT-PCR. beta1-, beta2- and beta 4-subunit mRNAs were expressed in rat TG whereas beta2- and beta 4-subunits were detected in porcine TG. Western blotting...

  9. Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis

    Science.gov (United States)

    Donelan, Matthew J.; Morfini, Gerardo; Julyan, Richard; Sommers, Scott; Hays, Lori; Kajio, Hiroshi; Briaud, Isabelle; Easom, Richard A.; Molkentin, Jeffery D.; Brady, Scott T.; hide

    2002-01-01

    The specific biochemical steps required for glucose-regulated insulin exocytosis from beta-cells are not well defined. Elevation of glucose leads to increases in cytosolic [Ca2+]i and biphasic release of insulin from both a readily releasable and a storage pool of beta-granules. The effect of elevated [Ca2+]i on phosphorylation of isolated beta-granule membrane proteins was evaluated, and the phosphorylation of four proteins was found to be altered by [Ca2+]i. One (a 18/20-kDa doublet) was a Ca2+-dependent increase in phosphorylation, and, surprisingly, three others (138, 42, and 36 kDa) were Ca2+-dependent dephosphorylations. The 138-kDa beta-granule phosphoprotein was found to be kinesin heavy chain (KHC). At low levels of [Ca2+]i KHC was phosphorylated by casein kinase 2, but KHC was rapidly dephosphorylated by protein phosphatase 2B beta (PP2Bbeta) as [Ca2+]i increased. Inhibitors of PP2B specifically reduced the second, microtubule-dependent, phase of insulin secretion, suggesting that dephosphorylation of KHC was required for transport of beta-granules from the storage pool to replenish the readily releasable pool of beta-granules. This is distinct from synaptic vesicle exocytosis, because neurotransmitter release from synaptosomes did not require a Ca2+-dependent KHC dephosphorylation. These results suggest a novel mechanism for regulating KHC function and beta-granule transport in beta-cells that is mediated by casein kinase 2 and PP2B. They also implicate a novel regulatory role for PP2B/calcineurin in the control of insulin secretion downstream of a rise in [Ca2+]i.

  10. alternativas para promoverla

    Directory of Open Access Journals (Sweden)

    Carlos Muñoz Izquierdo

    2006-01-01

    Finalmente, se analizan las políticas que han sido aplicadas con el fin de combatir ese problema, y se sugieren algunos cursos de acción que se consideran potencialmente más eficaces para lograr ese propósito.

  11. Silo para cereales. Bandholm

    Directory of Open Access Journals (Sweden)

    Editorial, Equipo

    1960-09-01

    Full Text Available El silo de Bandholm, para cereales, construido en la isla de Lolland, tiene una capacidad de 13 a 14.000 toneladas. Esta estructura se ha subdividido en células individuales de unas 400 toneladas de capacidad cada una. La obra ha sido proyectada y construida por Christiani & Nielsen.

  12. Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell mass.

    Directory of Open Access Journals (Sweden)

    Ji-Hyeon Lee

    2010-01-01

    Full Text Available Insulin-producing pancreatic islet beta cells (beta-cells are destroyed, severely depleted or functionally impaired in diabetes. Therefore, replacing functional beta-cell mass would advance clinical diabetes management. We have previously demonstrated the importance of Cdk4 in regulating beta-cell mass. Cdk4-deficient mice display beta-cell hypoplasia and develop diabetes, whereas beta-cell hyperplasia is observed in mice expressing an active Cdk4R24C kinase. While beta-cell replication appears to be the primary mechanism responsible for beta-cell mass increase, considerable evidence also supports a contribution from the pancreatic ductal epithelium in generation of new beta-cells. Further, while it is believed that majority of beta-cells are in a state of 'dormancy', it is unclear if and to what extent the quiescent cells can be coaxed to participate in the beta-cell regenerative response. Here, we address these queries using a model of partial pancreatectomy (PX in Cdk4 mutant mice. To investigate the kinetics of the regeneration process precisely, we performed DNA analog-based lineage-tracing studies followed by mathematical modeling. Within a week after PX, we observed considerable proliferation of islet beta-cells and ductal epithelial cells. Interestingly, the mathematical model showed that recruitment of quiescent cells into the active cell cycle promotes beta-cell mass reconstitution in the Cdk4R24C pancreas. Moreover, within 24-48 hours post-PX, ductal epithelial cells expressing the transcription factor Pdx-1 dramatically increased. We also detected insulin-positive cells in the ductal epithelium along with a significant increase of islet-like cell clusters in the Cdk4R24C pancreas. We conclude that Cdk4 not only promotes beta-cell replication, but also facilitates the activation of beta-cell progenitors in the ductal epithelium. In addition, we show that Cdk4 controls beta-cell mass by recruiting quiescent cells to enter the cell

  13. Immunocytochemical localization of inducible nitric oxide synthase and transforming growth factor-beta (TGF-beta) in leprosy lesions.

    Science.gov (United States)

    Khanolkar-Young, S; Snowdon, D; Lockwood, D N

    1998-09-01

    Inducible nitric oxide synthase (iNOS) and TGF-beta were localized by immunocytochemistry in skin lesions from patients across the leprosy spectrum, and from patients undergoing reversal reaction. iNOS expression was highest at the tuberculoid pole of the spectrum, and increased during reversal reaction. TGF-beta was observed throughout the leprosy spectrum, but was highest at the lepromatous pole. Levels of TGF-beta decreased during reversal reaction. Reduced levels of TGF-beta may contribute to unregulated inflammatory responses during reactional episodes.

  14. The Promiscuity of [beta]-Strand Pairing Allows for Rational Design of [beta]-Sheet Face Inversion

    Energy Technology Data Exchange (ETDEWEB)

    Makabe, Koki; Koide, Shohei (UC)

    2009-06-17

    Recent studies suggest the dominant role of main-chain H-bond formation in specifying {beta}-sheet topology. Its essentially sequence-independent nature implies a large degree of freedom in designing {beta}-sheet-based nanomaterials. Here we show rational design of {beta}-sheet face inversions by incremental deletions of {beta}-strands from the single-layer {beta}-sheet of Borrelia outer surface protein A. We show that a {beta}-sheet structure can be maintained when a large number of native contacts are removed and that one can design large-scale conformational transitions of a {beta}-sheet such as face inversion by exploiting the promiscuity of strand-strand interactions. High-resolution X-ray crystal structures confirmed the success of the design and supported the importance of main-chain H-bonds in determining {beta}-sheet topology. This work suggests a simple but effective strategy for designing and controlling nanomaterials based on {beta}-rich peptide self-assemblies.

  15. Molecular analysis of beta-globin gene mutations among Thai beta-thalassemia children: results from a single center study

    Directory of Open Access Journals (Sweden)

    Boonyawat B

    2014-12-01

    Full Text Available Boonchai Boonyawat,1 Chalinee Monsereenusorn,2 Chanchai Traivaree2 1Division of Genetics, Department of Pediatrics, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand; 2Division of Hematology/Oncology, Department of Pediatrics, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand Background: Beta-thalassemia is one of the most common genetic disorders in Thailand. Clinical phenotype ranges from silent carrier to clinically manifested conditions including severe beta-thalassemia major and mild beta-thalassemia intermedia. Objective: This study aimed to characterize the spectrum of beta-globin gene mutations in pediatric patients who were followed-up in Phramongkutklao Hospital. Patients and methods: Eighty unrelated beta-thalassemia patients were enrolled in this study including 57 with beta-thalassemia/hemoglobin E, eight with homozygous beta-thalassemia, and 15 with heterozygous beta-thalassemia. Mutation analysis was performed by multiplex amplification refractory mutation system (M-ARMS, direct DNA sequencing of beta-globin gene, and gap polymerase chain reaction for 3.4 kb deletion detection, respectively. Results: A total of 13 different beta-thalassemia mutations were identified among 88 alleles. The most common mutation was codon 41/42 (-TCTT (37.5%, followed by codon 17 (A>T (26.1%, IVS-I-5 (G>C (8%, IVS-II-654 (C>T (6.8%, IVS-I-1 (G>T (4.5%, and codon 71/72 (+A (2.3%, and all these six common mutations (85.2% were detected by M-ARMS. Six uncommon mutations (10.2% were identified by DNA sequencing including 4.5% for codon 35 (C>A and 1.1% initiation codon mutation (ATG>AGG, codon 15 (G>A, codon 19 (A>G, codon 27/28 (+C, and codon 123/124/125 (-ACCCCACC, respectively. The 3.4 kb deletion was detected at 4.5%. The most common genotype of beta-thalassemia major patients was codon 41/42 (-TCTT/codon 26 (G>A or betaE accounting for 40%. Conclusion: All of the beta-thalassemia alleles have been characterized by

  16. Effects of amphetamine and beta-endorphin fragments on maze performance in rats

    NARCIS (Netherlands)

    Bohus, B; de Boer, S.F.

    Fragments of beta-endorphin and amphetamine cause similar effects in some tests of maze behavior in rats. The present study served to compare the influence of amphetamine and two beta-endorphin fragments [beta-endorphin (beta E)-(2-9) and beta E-(2-16)] on maze behavior in more detail. In Experiment

  17. beta-Ureidopropionase deficiency: Phenotype, genotype and protein structural consequences in 16 patients

    NARCIS (Netherlands)

    van Kuilenburg, André B. P.; Dobritzsch, Doreen; Meijer, Judith; Krumpel, Michael; Selim, Laila A.; Rashed, Mohamed S.; Assmann, Birgit; Meinsma, Rutger; Lohkamp, Bernhard; Ito, Tetsuya; Abeling, Nico G. G. M.; Saito, Kayoko; Eto, Kaoru; Smitka, Martin; Engvall, Martin; Zhang, Chunhua; Xu, Wang; Zoetekouw, Lida; Hennekam, Raoul C. M.

    2012-01-01

    beta-Ureidopropionase is the third enzyme of the pyrimidine degradation pathway and catalyzes the conversion of N-carbamyl-beta-alanine and N-carbamyl-beta-aminoisobutyric acid to beta-alanine and beta-aminoisobutyric acid, ammonia and CO2. To date, only five genetically confirmed patients with a

  18. Comportamento da beta-ciclodextrina adicionada ao leite de cabra submetido ao processo de desidratação por "spray-dryer" Beta-ciclodextrin's behavior added goat's milk submitted to the "spray-dryer" dehydration process

    Directory of Open Access Journals (Sweden)

    Adriana C. P. Diniz

    2005-06-01

    Full Text Available Este trabalho avaliou o comportamento do agente encapsulante beta -ciclodextrina ( beta-CD adicionado ao leite de cabra submetido ao processo de desidratação por "spray-dryer", através de análise termogravimétrica e de cromatografia gasosa. Após a desidratação, a amostra adicionada de beta-CD apresentou um rendimento real de 10,59% com taxa de perda de 0,04% (em relação ao valor teórico esperado 10,6% ; enquanto na amostra sem adição do agente encapsulante o rendimento real foi de 9,57%, com taxa de perda de 4,27% (valor teórico esperado 10% . Através da análise termogravimétrica (TGA, verificou-se que são volatilizados 44% e 21% dos ácidos comerciais C8 e C10 , respectivamente. Os resultados cromatográficos mostraram uma perda de aproximadamente 30% dos ácidos C8 e 20% dos ácidos C10 , nas amostras de leite de cabra sem beta -CD em relação às amostras com beta-CD. Tais porcentagens estão de acordo com os valores estimados para os ácidos comerciais. Com base nos parâmetros estudados, podemos inferir que há menor perda dos ácidos graxos C8 e C10 na amostra de leite de cabra com beta-CD, provavelmente devido ao efeito encapsulante, aumentando a estabilidade térmica dos ácidos.This work evaluated the effect of the encapsulant agent beta-cyclodextrin (beta-CD added the goat milk submitted to the "spray-dryer" dehydration process, through thermogravimetric analysis and gas cromatography. After dehydration, the sample added of beta-CD presented a real yield of 10,59%, with a loss rate of 0,04% (in relation to the expected theoretical value 10,6%; while in the sample without addition of the encapsulant agent the real yield was 9,57%, with a loss rate of 4,27% (expected theoretical value 10% . It was verified that the volatilization of 44% and 21% of the commercial acids C8 and C10 , respectively, through the thermogravimetric analysis (TGA. The cromatographic results showed losses of approximately 30% of the C8 acids and

  19. Measurement of dose speed absorbed in depth imparted by sources external secondary patterns of beta radiation. Part 1 Measurement of dose speed absorbed in the surface of soft fabric for isotopes of {sup 90}Sr/{sup 90}Y, {sup 147}Pm and {sup 204}TI; Medicion de rapidez de dosis absorbida en profundidad impartida por fuentes patrones secundarios de radiacion beta externos. Parte 1. Medicion de rapidez de dosis absorbida en la superficie de tejido blando para isotopos de {sup 90}Sr/{sup 90}Y, {sup 147}Pm y {sup 204}TI

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, J.T. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    1993-01-15

    The dose speed was measured absorbed for depth zero, (superficial) in soft equivalent fabric, for the secondary pattern{sup s} four sources of beta radiation, (Nr. 86): {sup 90}Sr/{sup 90}Y, (1850 MBq and 74 MBq respectively); {sup 147}Pm, (518 MBq) and {sup 204}TI, (18.5 MBq). The measurement is carried out to different distances of source-detecting separation, (11.0, 30.0 and 50.0 cm for the source of 1850 MBq, 30.0 cm for that of 74 MBq; 11.00 cm for the source of {sup 147}Pmand to contact for all the sources); maintaining the radiation sheaf aligned the one axis of symmetry of the detector, ({alpha} 0 degrees). The detector employed was a extrapolation chambers of variable electrodes and electrode fixed collector, (30 mm of diameter). In accordance with the principle of Bragg-Gray the volume of the chambers is varied and they register the variations of the current of collected ionization, correcting until for a maximum of thirteen correction factors that take into account the deviation to the suppositions that it establishes this principle. The certain values of the speed of superficial absorbed dose are in the following intervals: {sup 90}Sr/{sup 90}Y, (1850 MBq, 0.0, 11.0, 30.0 and 50.0 cm): 43.164 mGy S-t, 0.544 mGy s-1 ,0.075 mGy s{sup -1} and 0.027 mGy s{sup -1}, respectively, with a Global Analysis of the order of 1.17%, 1.17%, 1.14% and 1.66%, K J; {sup 90}Sr / {sup 90}Y, (74 MBq, 0.0 and 30 cm): 1.536 mGy s{sup -1} and 0.002 mGy s{sup -1}, with Global Analysis of 1.19.0% and 5.22%, (K = 1) respectively, for the {sup 147}Pm, (0.0 and 11.0 in the interval of: 0.36 {mu}Gy s{sup -1} and 0.43 {mu}Gy s{sup -1}, with one Global Analysis of 1 .42% and 4.28%, (K = 1), respectively; and finally for the {sup 204}TI, (0.0 cm) in the interval of 0.10 {mu}Gy s{sup -1} with a Global Analysis of 1.27%. He calculates of the Global Analysis one carries out of agreement with those recommendations of the BIPM. In all the cases of source-detecting arrangement with

  20. TGF-{beta}-stimulated aberrant expression of class III {beta}-tubulin via the ERK signaling pathway in cultured retinal pigment epithelial cells

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Eun Jee [Department of Ophthalmology, National Health Insurance Corporation Ilsan Hospital, Gyeonggi-do (Korea, Republic of); Chun, Ji Na; Jung, Sun-Ah [Konyang University Myunggok Medical Research Institute, Kim' s Eye Hospital, Konyang University College of Medicine, Seoul (Korea, Republic of); Cho, Jin Won [Department of Biology, Yonsei University, 134 Shinchon-dong, Seodaemun-gu, Seoul 120-749 (Korea, Republic of); Lee, Joon H., E-mail: joonhlee@konyang.ac.kr [Konyang University Myunggok Medical Research Institute, Kim' s Eye Hospital, Konyang University College of Medicine, Seoul (Korea, Republic of)

    2011-11-18

    Highlights: Black-Right-Pointing-Pointer TGF-{beta} induces aberrant expression of {beta}III in RPE cells via the ERK pathway. Black-Right-Pointing-Pointer TGF-{beta} increases O-GlcNAc modification of {beta}III in RPE cells. Black-Right-Pointing-Pointer Mature RPE cells have the capacity to express a neuron-associated gene by TGF-{beta}. -- Abstract: The class III {beta}-tubulin isotype ({beta}{sub III}) is expressed exclusively by neurons within the normal human retina and is not present in normal retinal pigment epithelial (RPE) cells in situ or in the early phase of primary cultures. However, aberrant expression of class III {beta}-tubulin has been observed in passaged RPE cells and RPE cells with dedifferentiated morphology in pathologic epiretinal membranes from idiopathic macular pucker, proliferative vitreoretinopathy (PVR) and proliferative diabetic retinopathy (PDR). Transforming growth factor-{beta} (TGF-{beta}) has been implicated in dedifferentiation of RPE cells and has a critical role in the development of proliferative vitreoretinal diseases. Here, we investigated the potential effects of TGF-{beta} on the aberrant expression of class III {beta}-tubulin and the intracellular signaling pathway mediating these changes. TGF-{beta}-induced aberrant expression and O-linked-{beta}-N-acetylglucosamine (O-GlcNac) modification of class III {beta}-tubulin in cultured RPE cells as determined using Western blotting, RT-PCR and immunocytochemistry. TGF-{beta} also stimulated phosphorylation of ERK. TGF-{beta}-induced aberrant expression of class III {beta}-tubulin was significantly reduced by pretreatment with U0126, an inhibitor of ERK phosphorylation. Our findings indicate that TGF-{beta} stimulated aberrant expression of class III {beta}-tubulin via activation of the ERK signaling pathway. These data demonstrate that mature RPE cells have the capacity to express a neuron-associated gene in response to TGF-{beta} stimulation and provide useful information

  1. Overview of total beta activity index and beta rest in surface waters of the Spanish rivers; Vision general del indice de actividad beta total y beta resto en las aguas superficiales de los rios espanoles

    Energy Technology Data Exchange (ETDEWEB)

    Pujol, L.; Payeras, J.; Pablo, M. A. de

    2013-07-01

    This work aims to give an overview of the index of total beta activity and the activity index beta rest in surface waters of the main Spanish rivers. These indices are a parameter over water quality that CEDEX comes determined by order of the Ministry of Agriculture, Food and Environment, in water policy. (Author)

  2. Extended Spectrum Beta-lactam Resistance among Salmonella

    Science.gov (United States)

    Salmonella is an important food bourn pathogen capable of infecting both humans and animals. One of the most effective treatments for Salmonella infections is beta-lactam antibiotics, particularly extended spectrum beta-lactams; however, Salmonella resistant to these antibiotics have been recovered ...

  3. The effects of Beta-Endorphin: state change modification

    NARCIS (Netherlands)

    Veening, J.G.; Barendregt, H.P.

    2015-01-01

    Beta-endorphin (beta-END) is an opioid neuropeptide which has an important role in the development of hypotheses concerning the non-synaptic or paracrine communication of brain messages. This kind of communication between neurons has been designated volume transmission (VT) to differentiate it

  4. Plasma transforming growth factor beta levels in breast cancer patients

    NARCIS (Netherlands)

    Sminia, P; Barten, AD; Van Waarde, MAWH; Vujaskovic, Z; Van Tienhoven, G

    1998-01-01

    We investigated whether the concentration of circulating transforming growth factor beta (TGF beta) yields diagnostic value in breast cancer. Blood was collected from twenty stage I and II breast cancer patients both prior to treatment and after surgical excision of the tumour. Both latent and

  5. Beta Lactamase production by Staphylococcus aureus from children ...

    African Journals Online (AJOL)

    Isolates of Staphylococcus aureus from children aged 5 years and below with sporadic diarrhoea were tested for their ability to produce beta-lactamase enzyme. Of the 95 isolates tested 79 (83.2%) were beta-lactamase-producing strains. The study confirms that majority of clinical isolates of S. aureus from diarrhoeic ...

  6. The Beta Israel: Return to the source? | Zegeye | Africa Insight

    African Journals Online (AJOL)

    Even after more than two decades, over 70 000 Ethiopian Jews - the Beta Israel - have still not been fully accepted in Israel, in danger of becoming an ethnically defined 'under-class'. The potential of Beta Israel contributions to both Israeli and Ethiopian society should be recognised. Africa Insight Vol.34(1) 2004: 69-75 ...

  7. Nonionic emulsion-mediated synthesis of zeolite beta

    Indian Academy of Sciences (India)

    Zeolite beta synthesis was first carried out in a newly developed emulsion system containing nonionic polyoxyethylated alkylphenol surfactant, which showed interesting non-conventional features. Compared to the conventional hydrothermal synthesis of zeolite beta, the reported nonionic emulsion system showed a faster ...

  8. Neutrinoless double beta decay with small and hierarchical neutrino ...

    Indian Academy of Sciences (India)

    Evidence of atmospheric [1] and solar [2] neutrino oscillations has made the notion of neutrino mass generally acceptable. In the absence of any direct evidence of neutrino mass in plain old beta decay [3], a recent observation [4] of neutrinoless double beta decay [5] has made a second case of a large effective Majorana ...

  9. Changes in microstructure, beta carotene content and in vitro ...

    African Journals Online (AJOL)

    Orange-fleshed sweet potatoes {OFSP} (Ipomoea batatas (L.) Lam) contain high levels of beta carotene, an important provitamin A carotenoid. Stored sweet potato roots undergo many physiological changes that affect their beta carotene content and bioaccessibility as well as the tissue microstructure. This study ...

  10. Anaesthesia for a patient with beta thalassaemia major

    African Journals Online (AJOL)

    with anaemia. Defects in both alleles result in beta thalassaemia major, which results in a severe clinical picture requiring lifelong blood transfusions. A more moderate phenotype presenting with less blood transfusion dependence is called beta thalassaemia intermedia.1. The cause behind this differing severity of disease ...

  11. Evolutionary ecology of beta-lactam gene clusters in animals

    NARCIS (Netherlands)

    Suring, Wouter; Meusemann, Karen; Blanke, Alexander; Mariën, Janine; Schol, Tim; Agamennone, Valeria; Faddeeva-Vakhrusheva, Anna; Berg, Matty P; Brouwer, Abraham; van Straalen, Nico M; Roelofs, Dick

    Beta-lactam biosynthesis was thought to occur only in fungi and bacteria, but we recently reported the presence of isopenicillin N synthase in a soil-dwelling animal, Folsomia candida. However, it has remained unclear whether this gene is part of a larger beta-lactam biosynthesis pathway and how

  12. Beta blockers and their combinations in the management of ...

    African Journals Online (AJOL)

    Review Article: Beta blockers and their combinations in the management of hypertension. 409. Vol 54 No 5. S Afr Fam Pract 2012. Introduction. Beta blockers have been prescribed for the treatment of primary hypertension for a very long time. Currently, it is doubtful whether this is still a good idea. In fact, many are of the ...

  13. Perioperative beta blockers in patients having non-cardiac surgery

    DEFF Research Database (Denmark)

    Bangalore, Sripal; Wetterslev, Jørn; Pranesh, Shruthi

    2008-01-01

    American College of Cardiology and American Heart Association (ACC/AHA) guidelines on perioperative assessment recommend perioperative beta blockers for non-cardiac surgery, although results of some clinical trials seem not to support this recommendation. We aimed to critically review the evidence...... to assess the use of perioperative beta blockers in patients having non-cardiac surgery....

  14. Biomarker Responses to Beta Blocker Exposures in Marine Bivalves

    Science.gov (United States)

    Increased consumption and improper disposal of prescription medication, such as beta (β)-blockers, contribute to their introduction into waterways and pose threats to non-target aquatic organisms. Beta-blockers are widely prescribed for medical treatment of hypertension and ...

  15. Ascorbic Acid and Beta-Carotene Alleviate Oxidative Effect of ...

    African Journals Online (AJOL)

    Ascorbic Acid and Beta-Carotene Alleviate Oxidative Effect of London King Size® Cigarette Smoke on Tissue Lipids. ... Malondialdehyde production in the tissues was reduced by ascorbic acid and or beta-carotene given daily to the rats. It is implied that ascorbic acid or ... http://dx.doi.org/10.4314/njhbs.v2i1.11451.

  16. beta-Catenin regulates airway smooth muscle contraction

    NARCIS (Netherlands)

    Jansen, Sepp R.; Van Ziel, Anna M.; Baarsma, Hoeke A.; Gosens, Reinoud

    Jansen SR, Van Ziel AM, Baarsma HA, Gosens R. beta-Catenin regulates airway smooth muscle contraction. Am J Physiol Lung Cell Mol Physiol 299: L204-L214, 2010. First published May 14, 2010; doi:10.1152/ajplung.00020.2010.-beta-Catenin is an 88-kDa member of the armadillo family of proteins that is

  17. Rare and unexpected beta thalassemic mutations in Qazvin ...

    African Journals Online (AJOL)

    STORAGESEVER

    2010-01-04

    Jan 4, 2010 ... different mutations in the beta globin gene (HBB). So there are numerous gene mutations responsible for beta thalassemia. This disease can be induced in Iran by at. *Corresponding author. E-mail: sarokhani2002@yahoo.com. Tel: +98 281 2237269, +989121823059. Fax: +98 281. 3345862. least 43 ...

  18. Some results on non-central beta distributions

    Directory of Open Access Journals (Sweden)

    Andrea Ongaro

    2015-03-01

    Full Text Available In this paper a new non-central beta distribution is defined. Several properties are derived (including various representations and moments expressions both for the new and the standard non-central beta distribution, showing a greater tractability and interpretability of the former.

  19. Pathogenesis of A-beta+ ketosis-prone diabetes

    Science.gov (United States)

    A-beta+ ketosis-prone diabetes (KPD) is an emerging syndrome of obesity, unprovoked ketoacidosis, reversible beta-cell dysfunction, and near-normoglycemic remission. We combined metabolomics with targeted kinetic measurements to investigate its pathophysiology. Fasting plasma fatty acids, acylcarnit...

  20. Design of a superconducting low beta niobium resonator

    Indian Academy of Sciences (India)

    Abstract. The proposed high current injector for the superconducting Linac at the Inter-. University Accelerator Centre will have several accelerating structures, including a superconducting module which will contain low beta niobium resonators. A prototype resonator for the low beta module has been designed.

  1. Beta-cell Assembly for the Quad Gas Sampling Detector

    Energy Technology Data Exchange (ETDEWEB)

    Cooper, Matthew W.; Bowyer, Ted W.; McIntyre, Justin I.; Hayes, James C.; Heimbigner, Tom R.; Ripplinger, Michael D.; Thompson, Robert C.

    2008-05-05

    The beta-cells used in the beta-gamma detector have taken time to develop and to standardize the assembly of them. In making the assembly routine it is important to have step by step assembly instructions as well as a list of potential problems and their solutions. This document attempts to accomplish these goals.

  2. Facile synthesis of (S)-beta-hydroxy-beta-trichloromethylated aromatic ketones by the regioselective ring cleavage of chiral beta-trichloromethyl-beta-propiolactone under the Friedel-Crafts conditions

    NARCIS (Netherlands)

    Fujisawa, T; Ito, T; Fujimoto, K; Shimizu, M; Wynberg, H; Staring, EGJ

    1997-01-01

    The reaction of enantiomerically pure beta-trichloromethyl-beta-propiolactone (1) as a chiral building block with an aromatic compound in the presence of Lewis acid provided an acylated product with a chiral trichloromethyl carbinol moiety. The acylated product was used as an effective chiral

  3. Compartmentalization and transport in beta-lactam antibiotics biosynthesis

    NARCIS (Netherlands)

    Evers, ME; Trip, H; van den Berg, MA; Bovenberg, RAL; Driessen, AJM

    2004-01-01

    Classical strain improvement of beta-lactam producing organisms by random mutagenesis has been a powerful tool during the last century. Current insights in the biochemistry and genetics of beta-lactam production, in particular in the filamentous fungus Penicillium chrysogenum, however, make a more

  4. Plasma TGF beta level in rats after hemithoracic irradiation

    NARCIS (Netherlands)

    Vujaskovic, Z; Down, JD; vanWaarde, MAWH; vanAssen, AJ; Szabo, BG; Konings, AWT

    Changes in TGF-beta plasma levels were observed 18 weeks after hemithoracic irradiation in rats. This coincides with an increase in the breathing frequency, being most pronounced between 22 and 28 weeks after irradiation. The correlation suggests a potential role of the circulating TGF-beta in the

  5. Gastrointestinal hyperplasia with altered expression of DNA polymerase beta.

    Directory of Open Access Journals (Sweden)

    Katsuhiko Yoshizawa

    2009-08-01

    Full Text Available Altered expression of DNA polymerase beta (Pol beta has been documented in a large percentage of human tumors. However, tumor prevalence or predisposition resulting from Pol beta over-expression has not yet been evaluated in a mouse model.We have recently developed a novel transgenic mouse model that over-expresses Pol beta. These mice present with an elevated incidence of spontaneous histologic lesions, including cataracts, hyperplasia of Brunner's gland and mucosal hyperplasia in the duodenum. In addition, osteogenic tumors in mice tails, such as osteoma and osteosarcoma were detected. This is the first report of elevated tumor incidence in a mouse model of Pol beta over-expression. These findings prompted an evaluation of human gastrointestinal tumors with regard to Pol beta expression. We observed elevated expression of Pol beta in stomach adenomas and thyroid follicular carcinomas, but reduced Pol beta expression in esophageal adenocarcinomas and squamous carcinomas.These data support the hypothesis that balanced and proficient base excision repair protein expression and base excision repair capacity is required for genome stability and protection from hyperplasia and tumor formation.

  6. Role of IL-1beta in type 2 diabetes

    DEFF Research Database (Denmark)

    Dinarello, Charles A; Donath, Marc Y; Mandrup-Poulsen, Thomas

    2010-01-01

    To understand the role of inflammation as the fundamental cause of type 2 diabetes and specifically to examine the contribution of IL-1beta.......To understand the role of inflammation as the fundamental cause of type 2 diabetes and specifically to examine the contribution of IL-1beta....

  7. Limiting beta of stellarators with no net current

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, H.R.; Monticello, D.A.

    1981-01-01

    Using reduced nonlinear MHD equations, we find finite beta, resistive, l = 2 stellarator equilibria with no net current. We then investigate stability to low mode number internal MHD modes, and find beta limits comparable to tokamaks. Low shear equilibria appear to be substantially more stable than high shear.

  8. Beta blockers and their combinations in the management of ...

    African Journals Online (AJOL)

    type of calcium-channel blocker, e.g. amlodipine, but not with a nondihydropyridine type, e.g. verapamil. However, there is very little evidence of efficacy in this regard. What is the role of beta blockers? Beta blockers should not be prescribed as monotherapy for hypertension. They can be added to other drugs for blood.

  9. Design of a superconducting low beta niobium resonator

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 78; Issue 4. Design of a superconducting low beta niobium resonator ... In this paper we present details of the electromagnetic design of the low beta resonator, briefly discuss the mechanical and engineering design, and present results from the measurements on the ...

  10. Factors influencing beta-amylase activity in sorghum malt

    CSIR Research Space (South Africa)

    Taylor, JRN

    1993-09-01

    Full Text Available isozyme of pI approximately 4.4-4.5, unlike the many isozymes all of higher pI in barley. However, like barley, sorghum beta-amylase was more temperature-labile than its alpha-amylase. Beta-amylase activity in sorghum malt was increased by germination time...

  11. Encoded Extended Spectrum Beta-Lactamases Produced by ...

    African Journals Online (AJOL)

    acid was Glutamine following Arginine with 4.47. pI. In OXA beta-lactamase most frequent amino acid was lysine, glutamine, aspartic acid following other amino acids. Average pI of OXA beta-lactamase calculated was 9.03. Table 2: Distribution of TEM, SHV and OXA in bacterial isolates (n = 300: Note: Data in parenthesis ...

  12. AGS vertical beta function measurements for Run 15

    Energy Technology Data Exchange (ETDEWEB)

    Harper, C. [Brookhaven National Lab. (BNL), Upton, NY (United States); Ahrens, L. [Brookhaven National Lab. (BNL), Upton, NY (United States); Huang, H. [Brookhaven National Lab. (BNL), Upton, NY (United States); Schoefer, V. [Brookhaven National Lab. (BNL), Upton, NY (United States)

    2016-10-07

    One key parameter for running the AGS efficiently is by maintaining a low emittance. To measure emittance, one needs to measure the beta function throughout the cycle. This can be done by measuring the beta function at the ionization profile monitors (IPM) in the AGS. This tech note delves into the motivation, the measurement, and some strides that were made throughout Run15.

  13. The prion protein as a receptor for amyloid-beta

    NARCIS (Netherlands)

    Kessels, Helmut W.; Nguyen, Louis N.; Nabavi, Sadegh; Malinow, Roberto

    2010-01-01

    Increased levels of brain amyloid-beta, a secreted peptide cleavage product of amyloid precursor protein (APP), is believed to be critical in the aetiology of Alzheimer's disease. Increased amyloid-beta can cause synaptic depression, reduce the number of spine protrusions (that is, sites of synaptic

  14. Genetic analysis of beta1 integrin "activation motifs" in mice

    DEFF Research Database (Denmark)

    Czuchra, Aleksandra; Meyer, Hannelore; Legate, Kyle R

    2006-01-01

    Akey feature of integrins is their ability to regulate the affinity for ligands, a process termed integrin activation. The final step in integrin activation is talin binding to the NPXY motif of the integrin beta cytoplasmic domains. Talin binding disrupts the salt bridge between the alpha/beta t...

  15. Hemoglobin Bali (bovine): beta A 18(Bl)Lys leads to His: one of the "missing links" between beta A and beta B of domestic cattle exists in the Bali cattle (Bovinae, Box banteng).

    Science.gov (United States)

    Namikawa, T; Takenaka, O; Takahashi, K

    1983-08-01

    The structure of the beta chain of adult bovine hemoglobin Bali of the Bali cattle was determined and compared to those of beta A, beta B, and other beta-chain variants of domestic cattle reported previously. The lysine residue at beta A18 was substituted by histidine in beta Bali18. This change requires two base substitutions at the codon and is also found in beta B18. The beta B chain differs from the beta A chain at residue Nos. 15, 18, and 119. It was concluded that a common ancestor of the beta B and beta Bali first diverged from the beta A chain through the Lys leads to His substitution. This fact indicates that the high degree of dimorphism of the beta A and beta B chains in Indian humped cattle is a result of its hybrid origin. An evolutionary tree for the bovine hemoglobin beta-chain variants was constructed based on parsimonious evolution and homology with related species.

  16. Interleukin-1 beta Attenuates Myofibroblast Formation and Extracellular Matrix Production in Dermal and Lung Fibroblasts Exposed to Transforming Growth Factor-beta 1

    NARCIS (Netherlands)

    Mia, Masum M.; Boersema, Miriam; Bank, Ruud A.

    2014-01-01

    One of the most potent pro-fibrotic cytokines is transforming growth factor (TGF beta). TGF beta is involved in the activation of fibroblasts into myofibroblasts, resulting in the hallmark of fibrosis: the pathological accumulation of collagen. Interleukin-1 beta (IL1 beta) can influence the

  17. Molecular cloning and phylogenetic analysis of integrins alpha v beta 1 and alpha v beta 6 of one-humped camel (Camelus dromedarius)

    DEFF Research Database (Denmark)

    Du, Junzheng; Larska, Magdalena Larska; Chang, Huiyun

    2010-01-01

    , and 787 amino acids, respectively. The dromedary camel integrin alpha v, beta 1, and beta 6 subunit shares common structural and functional elements with their counterparts from the other species. Phylogenetic trees showed that the dromedary camel alpha v, beta 1, and beta 6 were clustered...

  18. ACAT inhibition and amyloid beta reduction.

    Science.gov (United States)

    Bhattacharyya, Raja; Kovacs, Dora M

    2010-08-01

    Alzheimer's disease (AD) is a devastating neurodegenerative disorder. Accumulation and deposition of the beta-amyloid (Abeta) peptide generated from its larger amyloid precursor protein (APP) is one of the pathophysiological hallmarks of AD. Intracellular cholesterol was shown to regulate Abeta production. Recent genetic and biochemical studies indicate that not only the amount, but also the distribution of intracellular cholesterol is critical to regulate Abeta generation. Acyl-coenzyme A: cholesterol acyl-transferase (ACAT) is a family of enzymes that regulates the cellular distribution of cholesterol by converting membrane cholesterol into hydrophobic cholesteryl esters for cholesterol storage and transport. Using pharmacological inhibitors and transgenic animal models, we and others have identified ACAT1 as a potential therapeutic target to lower Abeta generation and accumulation. Here we discuss data focusing on ACAT inhibition as an effective strategy for the prevention and treatment of AD. Copyright 2010 Elsevier B.V. All rights reserved.

  19. CPS Transformation of Beta-Redexes

    DEFF Research Database (Denmark)

    Danvy, Olivier; Nielsen, Lasse R.

    2000-01-01

    The extra compaction of the most compacting CPS transformation in existence, which is due to Sabry and Felleisen, is generally attributed to (1) making continuations occur first in CPS terms and (2) classifying more redexes as administrative. We show that this extra compaction is actually...... independent of the relative positions of values and continuations and furthermore that it is solely due to a context-sensitive transformation of beta-redexes. We stage the more compact CPS transformation into a first-order uncurrying phase and a context-insensitive CPS transformation. We also define a context......-insensitive CPS transformation that provides the extra compaction. This CPS transformation operates in one pass and is dependently typed....

  20. CPS Transformation of Beta-Redexes

    DEFF Research Database (Denmark)

    Danvy, Olivier; Nielsen, Lasse

    2005-01-01

    The extra compaction of the most compacting CPS transformation in existence, which is due to Sabry and Felleisen, is generally attributed to (1) making continuations occur first in CPS terms and (2) classifying more redexes as administrative. We show that this extra compaction is actually...... independent of the relative positions of values and continuations and furthermore that it is solely due to a context-sensitive transformation of beta-redexes. We stage the more compact CPS transformation into a first-order uncurrying phase and a context-insensitive CPS transformation. We also define a context......-insensitive CPS transformation that provides the extra compaction. This CPS transformation operates in one pass and is dependently typed....