Wirevagn : Utvecklingen av en utrullare för hisslinor

OpenAIRE

Rehnsfeldt, Patrik

2014-01-01

Kandidatexamensarbetet som utgick från en förfrågan från företaget Irongrip AB hade som mål att utveckla ett produktförslag på en utlindare av stålvajer för hissmontörer. Irongrip AB som tillverkar och säljer verktyg för hantering av stålvajer hade uppmärksammat att en efterfrågan på en sådan produkt fanns på marknaden då befintliga lösningar var bristfälliga och inte hade alla de funktioner som är önskvärda hos en sådan produkt.Arbetet inleddes med en förstudie där studiebesök vid lindragnin...

Determination of the k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} correction factors for detectors used with an 800 MU/min CyberKnife{sup ®} system equipped with fixed collimators and a study of detector response to small photon beams using a Monte Carlo method

Energy Technology Data Exchange (ETDEWEB)

Moignier, C., E-mail: cyril.moignier@free.fr; Huet, C. [Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Service de Dosimétrie Externe, 92260, Fontenay-aux-Roses (France); Makovicka, L. [IRMA/CE UMR 6249 CNRS, Université de Franche-Comté, 25200, Montbéliard (France)

2014-07-15

Purpose: In a previous work, output ratio (OR{sub det}) measurements were performed for the 800 MU/min CyberKnife{sup ®} at the Oscar Lambret Center (COL, France) using several commercially available detectors as well as using two passive dosimeters (EBT2 radiochromic film and micro-LiF TLD-700). The primary aim of the present work was to determine by Monte Carlo calculations the output factor in water (OF{sub MC,w}) and the k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} correction factors. The secondary aim was to study the detector response in small beams using Monte Carlo simulation. Methods: The LINAC head of the CyberKnife{sup ®} was modeled using the PENELOPE Monte Carlo code system. The primary electron beam was modeled using a monoenergetic source with a radial gaussian distribution. The model was adjusted by comparisons between calculated and measured lateral profiles and tissue-phantom ratios obtained with the largest field. In addition, the PTW 60016 and 60017 diodes, PTW 60003 diamond, and micro-LiF were modeled. Output ratios with modeled detectors (OR{sub MC,det}) and OF{sub MC,w} were calculated and compared to measurements, in order to validate the model for smallest fields and to calculate k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} correction factors, respectively. For the study of the influence of detector characteristics on their response in small beams; first, the impact of the atomic composition and the mass density of silicon, LiF, and diamond materials were investigated; second, the material, the volume averaging, and the coating effects of detecting material on the detector responses were estimated. Finally, the influence of the size of silicon chip on diode response was investigated. Results: Looking at measurement ratios (uncorrected output factors) compared to the OF{sub MC,w}, the PTW 60016

Solcellsparkeringen : En jämförande fallstudie för elbilar och bensinbilar

OpenAIRE

Myrén Andersson, Isac; Yttermyr-Sütt, Frans

2017-01-01

Av Sveriges totala växthusgasutsläpp är det i nuläget transportsektorn som står för den största andelen och står för mer än 30 % av alla utsläpp. Med ett ökande fordonsbestånd och ett fortsatt behov av transporter blir lösningar som minskar utsläppen från denna sektor avgörande för Sveriges hållbara utveckling. Eftersom 93 % av Sveriges drygt 4,7 miljoner personbilar drivs av fossila bränslen skulle investeringar i alternativa färdmedel såsom elbilar kunna leda Sverige i rätt riktning. Förfat...

Neuroligin 2 R215H Mutant Mice Manifest Anxiety, Increased Prepulse Inhibition, and Impaired Spatial Learning and Memory

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Chia-Hsiang Chen

2017-11-01

Full Text Available Neuroligin 2 (NLGN2 is a postsynaptic adhesion protein that plays an essential role in synaptogenesis and function of inhibitory neuron. We previously identified a missense mutation R215H of the NLGN2 in a patient with schizophrenia. This missense mutation was shown to be pathogenic in several cell-based assays. The objective of this study was to better understand the behavioral consequences of this mutation in vivo. We generated a line of transgenic mice carrying this mutation using a recombinant-based method. The mice were subjected to a battery of behavioral tests including open field locomotor activity assay, prepulse inhibition (PPI assay, accelerated rotarod test, novel location and novel recognition tests, elevated plus-maze (EPM test, and Morris water maze test. The transgenic animals were viable and fertile, but the Nlgn2 R215H knock-in (KI homozygous mice showed growth retardation, anxiety-like behavior, increased PPI, and impaired spatial learning and memory. There was no significant interaction between sex and genotype in most behavioral tests; however, we observed a significant interaction between sex and genotype in EPM test in this study. Also, we found that the Nlgn2 R215H homozygous KI mice did not express the NLGN2 protein, resembling Nlgn2 knockout mice. Our results demonstrate that Nlgn2 R215H KI homozygous mice manifest several behavioral abnormalities similar to those found in psychiatric patients carrying NLGN2 mutations, indicating that dysfunction of NLGN2 contributes to the pathogenesis of certain psychiatric symptoms commonly present in various mental disorders, not limited to schizophrenia.

Tensor product of left n-invertible operators

Czech Academy of Sciences Publication Activity Database

Duggal, B.P.; Müller, Vladimír

2013-01-01

Roč. 215, č. 2 (2013), s. 113-125 ISSN 0039-3223 R&D Projects: GA ČR GA201/09/0473 Institutional support: RVO:67985840 Keywords : Banach space * essentially left n- invertible operator * left n-invertible operator Subject RIV: BA - General Mathematics Impact factor: 0.630, year: 2013 http://journals.impan.pl/cgi-bin/doi?sm215-2-2

Evidence of preorganization in quinonoid intermediate formation from L-Trp in H463F mutant Escherichia coli tryptophan indole-lyase from effects of pressure and pH.

Science.gov (United States)

Phillips, Robert S; Kalu, Ukoha; Hay, Sam

2012-08-21

The effects of pH and hydrostatic pressure on the reaction of H463F tryptophan indole-lyase (TIL) have been evaluated. The mutant TIL shows very low activity for elimination of indole but is still competent to form a quinonoid intermediate from l-tryptophan [Phillips, R. S., Johnson, N., and Kamath, A. V. (2002) Biochemistry 41, 4012-4019]. Stopped-flow measurements show that the formation of the quinonoid intermediate at 505 nm is affected by pH, with a bell-shaped dependence for the forward rate constant, k(f), and dependence on a single basic group for the reverse rate constant, k(r), with the following values: pK(a1) = 8.14 ± 0.15, pK(a2) = 7.54 ± 0.15, k(f,min) = 18.1 ± 1.3 s(-1), k(f,max) = 179 ± 46.3 s(-1), k(r,min) = 11.4 ± 1.2 s(-1), and k(r,max) = 33 ± 1.6 s(-1). The pH effects may be due to ionization of Tyr74 as the base and Cys298 as the acid influencing the rate constant for deprotonation. High-pressure stopped-flow measurements were performed at pH 8, which is the optimum for the forward reaction. The rate constants show an increase with pressure up to 100 MPa and a subsequent decrease above 100 MPa. Fitting the pressure data gives the following values: k(f,0) = 15.4 ± 0.8 s(-1), ΔV(‡) = -29.4 ± 2.9 cm(3) mol(-1), and Δβ(‡) = -0.23 ± 0.03 cm(3) mol(-1) MPa(-1) for the forward reaction, and k(r,0) = 20.7 ± 0.8 s(-1), ΔV(‡) = -9.6 ± 2.3 cm(3) mol(-1), and Δβ(‡) = -0.05 ± 0.02 cm(3) mol(-1) MPa(-1) for the reverse reaction. The primary kinetic isotope effect on quinonoid intermediate formation at pH 8 is small (~2) and is not significantly pressure-dependent, suggesting that the effect of pressure on k(f) may be due to perturbation of an active site preorganization step. The negative activation volume is also consistent with preorganization of the ES complex prior to quinonoid intermediate formation, and the negative compressibility may be due to the effect of pressure on the enzyme conformation. These results support the

The Beckman-Quarles theorem for continuous mappings from R^n to C^n

OpenAIRE

Tyszka, Apoloniusz

2002-01-01

Let \\phi((x_1,...,x_n),(y_1,...,y_n))=(x_1-y_1)^2+...+(x_n-y_n)^2. We say that f:R^n -> C^n preserves distance d>=0 if for each x,y \\in R^n \\phi(x,y)=d^2 implies \\phi(f(x),f(y))=d^2. We prove that if x,y \\in R^n (n>=3) and |x-y|=(\\sqrt{2+2/n})^k \\cdot (2/n)^l (k,l are non-negative integers) then there exists a finite set {x,y} \\subseteq S(x,y) \\subseteq R^n such that each unit-distance preserving mapping from S(x,y) to C^n preserves the distance between x and y. It implies that each continuou...

Enzymatic in-situ generation of H2O2 for decolorization of Acid Blue 113 by fenton process

Directory of Open Access Journals (Sweden)

Karimi Afzal

2012-01-01

Full Text Available Decolorization of Acid Blue 113 in an aqueous medium by bio-Fenton process has been investigated in this research. Enzymatic oxidation of glucose was performed to in-situ generation of H2O2 which was employed to react with Fe2+ for producing hydroxyl radicals. The effect of various parameters include concentrations of 113, glucose, and FeSO4, activity of glucose oxidase (GOx and the effect of pH were assessed. The highest decolorization of AB 113 were achieved at Fe2+ concentration of 0.2 mmol/L, pH =4.0, glucose concentration of 0.018 mol/L, and glucose oxidase activity of 2500 U/L in the constant temperature (23 ±0.1ºC and constant shaking rate (160 r/min, while the concentration of 113 was 40 mg/L. In these conditions, 113 decolorization efficiency after 60 min was obtained about 95%.

"Stendum, feg och impotent är Turkiets president" : En kvalitativ innehållsanalys av den tyska mediedebatten om Jan Böhmermann-affären utifrån olika argument för yttrandefrihet.

OpenAIRE

Lindström, Malin

2017-01-01

Den här uppsatsen undersöker argument för yttrandefrihet som framkommit i den så kallade Böhmermannaffären som inträffade våren 2016 i Tyskland, då den tyska satirikern Jan Böhmermann läste upp en niddikt om Turkiets president Recep Tayyip Erdoğan. Erdoğan kände sig kränkt och anmälde Böhmermann enligt ett tyskt lagrum. Undersökningen syftar till att utröna vilka typargument för yttrandefrihet som framkommit i debatten om Böhmermannaffären från olika aktörer och utifrån vilket intresse dessa ...

In-beam γ-ray spectroscopy of N=84 nuclei above Gd and the impact of the (πh11/2νh9/2)1+ attraction on their yrast lines

International Nuclear Information System (INIS)

Zhang Chengteng.

1993-12-01

In in-beam experiments using the γ-spectrometers Nordball at the Niels Bohr Institute and Osiris at the Hahn-Meitner Institute we populated the four N = 84 isotones 151 Ho, 152 Er, 153 Tm and 154 Yb through compound evaporation reactions induced with medium HI beams of masses ranging from 28 to 56. All observed γ-transitions with intensities above 1% (5% in 154 Yb) of the respective exit channel were placed in the level schemes, with spins established up to 10 MeV (8 MeV for 154 Yb) and parties up to between 5 and 7 MeV. We have found that in these N = 84 nuclei the multi-valence particle configurations πh n 11/2 νf 2 7/2 and πh n 11/2 νf 7/2 h 9/2 are strongly populated in the yrast cascades, and we have observed them up to their maximum spins of 43/2 - in Ho (at 4.8 MeV), 24 + in Er (7.5 MeV), 51/2 - in Tm (6.9 MeV), and only up to 24 + in Yb, 0.5 MeV below the fully aligned 26 + state expected at 9.1 MeV. The πh n νf 2 configuration forms smooth sections of the yrast line, while the more irregular yrast line of the πh n νfh character reflects the strong (νfh)8 + two-body attraction which gives rise to pronounced yrast line dips. We have also carried out full shell model calculations of these yrast lines, which are in excellent agreement with the experimental data. Since we take all dynamic input values, i.e. the two-body matrix elements and the single particle energies, from experiment, the calculations are free of any adjusted parameter. An interesting new result is the systematic identification in the πh n 11/2 νfh configuration of yrast states formed by specific proton couplings, where the strongly attractive (πh 11/2 νh 9/2 )1 + interaction is activated. As a consequence these states drop down to the yrast lines and in energy below the maximum aligned state of the next lower proton seniority. These seniority inverted yrast states were systematically identified in the four N = 84 nuclei, including two such states in 153 T, the first N 84

Komplexitet för kvalitet i lärande och undervisning: bedömning av komplexa problem och studenters resonemang

Directory of Open Access Journals (Sweden)

Sofia Kjellström

2011-03-01

Full Text Available Vi utbildar studenter för att de ska ha möjlighet att lösa mycket komplexa samhällsproblem,men hur vet vi att de har utvecklat de former av tänkande och handlande som krävs? Forskning visar att vuxna tänker, talar och handlar utifrån olika nivåer av komplexitet, och att utbildning i hög grad påverkar människors förmågor. Model of Hierarchical Complexity(MHC är en teori som beskriver hur komplext information sätts samman och hur komplext personer resonerar i en fråga, vanligtvis på någon av nivåerna konkret, abstrakt, formellt, systematiskt eller metasystematisk. Syftet med denna artikel är att introducera MHC och visa på dess relevans som verktyg inom högre utbildning. Med hjälp av teorin är det möjligt att analysera både hur komplex en uppgift är och hur studenter klarar av att lösa den, vilket speglar förståelse inom ett ämne. Med modellen som mått på komplexitet tydliggörs svårighetsgraden i det som ska läras och på vilken nivå studenterna klarar att ta till sig kunskapsinnehållet. Avslutningsvis diskuteras hur studenter kan stödjas att utvecklasina förmågor till komplext resonerande och därmed skapa kvalitet i både lärande och undervisningOne of the aims of higher education is to teach students to solve complex problems, but what is the complexity of problems and the reasoning of students? The Model of Hierarchical Complexity (MHC is a theory applicable to all domains in which information is organized and accounts for increases in behavioral complexity which includes cognitive or reasoning complexity. The paper is a theoretical introduction to MHC as a tool for teaching in higher education. The model clarifies and shows the gap between the complexity in the subject and the students understanding of the same subject. We also discuss how to support the development of more complex reasoning in students.

S.Y.L.V.E.S.T.R.E. database for quality and radioecological expertise at I.R.S.N; La base de donnees S.Y.L.V.E.S.T.R.E. au service de la qualite et de l'expertise en radioecologie a l'IRSN

Energy Technology Data Exchange (ETDEWEB)

Duffa, C. [IRSN/DEI/SESURE/LERCM, 83 - La Seyne-sur-Mer (France); Antonelli, C.; Vray, F.; Salaun, G. [CEA Cadarache, IRSN/DEI/SESURE/LERCM, 13 - Saint-Paul-lez-Durance (France); Marant, M.J. [Communication and Systemes, 13 - St Paul-Lez-Durance (France)

2007-04-15

S.Y.L.V.E.S.T.R.E. is an I.R.S.N. database, allowing improvement and storage of data concerning radioactivity measurements on environmental samples. Continuously supplied and upgraded since its creation in 1991, it is now an essential tool for quality. It is also a precious tool used by experts. Users have an easy access to the dedicated interface through internal I.R.S.N. network. They can introduce data concerning sample collections, preparations and measurements, export sections of data for checking or assessment. Several peripheral tools or programs (numerical field tablets, bar-code sample labelling, multi-criterion requests automation,...) have been developed in order to improve the application and to minimize manual data captures or replicates. (authors)

Tillverkningsmetod för tillverkning av däcksluckor med glas

OpenAIRE

Gripenberg, Lars

2010-01-01

Arbetet går ut på att hitta ett system för att tillverka däcksluckor med glas internt på Nautor. Detta är idag en produkt som vi köper utifrån av en extern leverantör till höga priser därför att vi inte själva har ett fungerande koncept för dylika produkter. Arbetet består av att kartlägga vilka olika tillverkningsmetoder som finns som är lämpade för detta ändamål, (Handlaminat, Injecering, Prepreg, mm). En eller två tillverkningsmetoder väljs ut och därefter tillverkas ett provexemp...

Release quantification in {sup 18}F from the confines number 4 of the Laboratory 16 of the S.H.F.J. at Orsay; Quantification des rejets en {sup 18}F de l'enceinte n. 4 du Laboratoire 16 du S.H.F.J. d'Orsay

Energy Technology Data Exchange (ETDEWEB)

Lecacheux, E. [CEA Saclay, 91 - Gif sur Yvette (France); Guelin, M.; Fauquant, J.M.; Thomas, F.; Boden, R. [CEA Saclay, Direction des Sciences de la Matiere (DSM/SPR), 91 - Gif-sur-Yvette (France)

2007-07-01

The object of this study is to determine the yields of trapping of the sampling system (French acronym:P.I.A.F.F. for iodine sample and aerosol with an immovable filter) put in place in order to characterize the gaseous effluents in {sup 18}F emitted during a Fluoro-L-Dopa synthesis. The yields are low for the two studied kinds (we are far from the yield of 100% used for the iodine trapping). The use of active carbon is not recommended in view of the disparity of the trapping yields in function of the different synthesised molecules (or different synthesis). The use of the T.C.R.( table of radiological control) as quantification mean of gaseous release become the benchmark mean; there is a correct correlation between the release got by gaseous sampling and the release measured by the T.C.R..The analysis reports have shown the lack of other radionuclides, the information delivered by the T.C.R. is consequently specific to {sup 18}F. Uncertainties calculations on rates, on trapping yields as well as released activities have been tackled and should be finalized in order to associate them to the results. Other tests should be thereafter realised in order to improve the trapping yields. (N.C.)

Trаnsfоrmаtiоn оf Institutiоnаl Structurе in thе Vоlgа Rеgiоn in 1917: Drivеrs аnd Stаgеs оf thе Рrоcеss

Directory of Open Access Journals (Sweden)

Viktоr N. Dаnilоv

2017-12-01

Full Text Available The peculiаrity of interconnection аnd interdependence of the power’s аnd society’s аctions in Russiаn regions аs а complex of emerged circumstаnces cаused by the revolution hаs become the subject of speciаl considerаtion in historiogrаphy of our country quite recently. Rаising this problem hаs given the opportunity to study the sociаl аnd psychologicаl аspects of the revolution the result of which is the аcceptаnce of the conflict between modernizаtion of аuthoritаtive аnd intellectuаl elite аnd trаditionаlism аnd discrepаncy of sociаl reflection аnd people’s аrchаic chаrаcter in the course of the revolutionаry process in provinces in 1917. On the bаsis of the Volgа region mаteriаls it is shown how in the conditions of the 1917 system crisis, trаnsformаtion of the institutionаl structure of the Russiаn stаtehood took plаce. Interconnection of the formаtion аnd functioning of аuthoritаtive bodies аnd revolutionаry аctions of the mаjority of society is determined. Institutionаl chаnges sequentiаlly pаssed some stаges from democrаcy through ochlocracy to dictаtorship, thus highlighting а syncretic model of the sociаl order. The аuthoritаtive system thаt hаd emerged аfter the Februаry – Mаrch revolution did not turn out to conform to аn аccepted view of the mаjority of society аnd cаused а powerful opposite wаve which brought the country to nаtionаl disаster. Аll аttempts of liberаl аnd moderаte revolutionаry forces to introduce democrаtic principles of sociаl order chаrаcteristic of western countries fаiled especiаlly in provinces where trаditionаl bаses were stronger. To overcome revolutionаry crisis the Bolsheviks mаnаged to use councils (soviets which were even less аble to cаrry out the functions of stаte governаnce but which demonstrаted а form of democrаcy. Lаter аll locаl initiаtive аssociаtions were grаduаlly elimin

Radiosynthesis of 3-{l_brace}[4-(4-[{sup 18}F]fluorobenzyl)]piperazin-1-yl{r_brace}methyl-1H-pyrrolo[2,3-b]pyridine: A potential dopamine D{sub 4} receptor imaging agent

Energy Technology Data Exchange (ETDEWEB)

Haibin Tian; Duanzhi Yin; Junling Li; Lan Zhang; Cunfu Zhang; Yongxian Wang; Wei Zhou [Radiopharmaceutical Research Center, Shanghai Inst. of Nuclear Research, The Chinese Academy of Sciences, Shanghai, SH (China)

2003-07-01

The dopamine D{sub 4} receptor (D{sub 4}R) is expressed in low density in various extrastriatal brain regions. This receptor subtype is discussed in relation to the pathophysiology and treatment of schizophrenia but to date no selective positron emission tomography (PET) ligand is available to study its distribution in vivo. The 7-azaindole derivative 3-([4-(4-iodophenyl)piperazin-1-yl]-methyl)-1H-pyrrolo [2,3-b]pyridine (L-750,667) is a novel, high-affinity (K{sub i}=0.51nM) and selective D{sub 4}R ligand. L-750,667 analogue 3-[4-(4-[{sup 18}F]fluorobenzyl)]piperazin-1-yl methyl-1H-pyrrolo[2,3-b]-pyridine was prepared by reacting 3-(piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine with 4-[ 18F]fluorobenzaldehyde, which was labeled with no carrier added [ 18F]fluoride. The radiochemical yield of 3-[4-(4-[{sup 18}F]fluorobenzyl)]piperazin-1-yl methyl-1H-pyrrolo[2,3-b]pyridine was 12.0% at end of synthesis (EOS), and the synthesis time was 73min. The labeled benzaldehydes may be useful precursors for the radiosyntheses of other complex radiotracers for PET.

2. Sınıf Türkçe Ders Kitabındaki Metinlerin Okunabilirlik Açısından İncelenmesi

Directory of Open Access Journals (Sweden)

BAYRAM BAŞ

2015-01-01

Full Text Available Ülkemiz, uluslararası platformda okuma becerilerini, okuryazarlığı ve alan becerilerini ölçmeyi hedefleyen PISA, PIRLS (2001 ve TIMSS sınavlarında ortalamanın altında kalmaktadır. Bu durum okuma becerisine sahip olmayan bireyler yetiştirilmesi ile doğru orantılıdır. Okuma okunabilirlik, anlaşılabilirlik ve okunaklık kavramlarını içinde bulunduran bir süreçtir. Okumanın önemli bir ayağı olan okunabilirlikle ilgili çalışmaların geçmişinin çok eskiye dayanmadığı bilinmekle birlikte, eksikliği tartışılmaz bir gerçektir. Türkçenin yapısına uygun hâle getirilmeye çalışılan okunabilirlik formülleri ile çalışmalar yapılsa da istenilen sonuca tam olarak ulaşıldığını söylemek güçtür. Bu çalışma, 2. sınıf Türkçe ders kitabındaki metinlerin okunabilirlik düzeylerini belirlemek amacıyla yapılmıştır. Araştırmada 2014-2015 eğitim-öğretim yılında okutulan Doku Yayınları’na ait 2. Sınıf Türkçe ders kitabındaki öyküleyici ve bilgilendirici metinlerin okunabilirlik düzeyleri ölçülmüş, şiirler kapsam dışında bırakılmıştır. Metinlerin analizinde Ateşman (1997’ın Türkçeye uyarladığı okunabilirlik formülü kullanılmıştır. Araştırma sonucuna göre, öyküleyici metinlerin okunabilirlik puanlarının bilgilendirici metinlerin okunabilirlik puanlarına göre daha yüksek olduğu tespit edilmiştir.

Temel eğitimden ortaöğretime geçiş sınavlarına ilişkin 9. sınıf öğrencilerinin görüşleri

OpenAIRE

Akman, Ozan

2017-01-01

Araştırmanın amacı, temel eğitimden ortaöğretime geçişte yapılmakta olan Temel Eğitimden Ortaöğretime Geçiş (TEOG) Sınavlarına ilişkin dokuzuncu sınıf öğrencilerinin görüşlerinin incelenmesidir. Araştırmada betimsel araştırma yöntemlerinden tarama modeli çerçevesinde nicel yöntem kullanılmıştır. Araştırmanın evrenini 2015-2016 eğitim öğretim yılında Zonguldak ili Ereğli ilçesinde devlet okullarında öğrenim gören 2715 dokuzuncu sınıf öğrencisi oluşturmaktadır. Araştırmanın örneklemini 1022 öğr...

Lärplatta som verktyg för elever i behov av särskilt stöd! : En specialpedagogisk studie om hur elever i åk 4-7 använder lärplatta i klassrummet och hur uppföljning av användningen sker

OpenAIRE

Lindgren, Ditte; Nordström, Ulrika

2017-01-01

Studiens syfte var att få kunskap om hur lärplatta används som verktyg för elever i behov av särskilt stöd i åk 4-7, samt om lärplattan används utifrån specialpedagogens syfte för den enskilda eleven med den. Använda datainsamlingsmetoder är kvalitativa intervjuer med specialpedagoger, lärare och elever, samt elevobservationer. De frågeställningar som studien sökt svar på är: i vilket syfte valdes lärplatta som verktyg av specialpedagog för elever i behov av särskilt stöd, hur använder elever...

Gemensam modell för professionella : E-klubb för närståendevårdare till personer med Multipel Skleros

OpenAIRE

Ekholm, Johanna; Lukkari, Noora; Nordberg, Marie; Parviainen, Jolanda

2017-01-01

Detta examensarbete är en del av ett projekt som Yrkeshögskolan Novia inledde redan våren 2016. Syftet med arbetet är främja hälsa och välbefinnande samt stöda och stärka närståendevårdarens egna resurser. Målet med arbetet är att skapa en gemensam modell för en e-klubb som skall användas av professionella. Grunden för arbetet har varit tjänstedesign och litteraturöversikt. Arbetet är uppdelat i två delar: en gemensam modell för uppbyggandet av en e klubb samt en målgruppsspecifik del. Den...

Leaning av arbetspunkt för urindiagnostik

OpenAIRE

Romar, Arne Johannes

2017-01-01

Lean är en metod som ämnar förbättra arbetsprocesser, öka kvalitén och förhindra slöseri av resurser. Fler och fler företag och institutioner i västvärlden har den senaste tiden börjat implementera läran och verktygen som ursprungligen kom från Toyota och deras produktionssystem. Sjukhus och sjukhuslaboratorier är inget undantag, patienterna och provmängderna blir större samtidigt som krav på inbesparningar sker. Därför behövs alternativa lösningar i form av lean för att få tillstånd en effek...

Stakes of a cooperation: preliminary inquiry led with the C.L.I. and I.R.S.N

International Nuclear Information System (INIS)

Gadbois, S.; Vaillant, L.

2004-01-01

The national association of local commissions of information (A.N.C.L.I.) and the institute of radiation protection and nuclear safety (I.R.S.N.) agreed to define experimental actions for year 2004 within the framework of their protocol concerning the scientific and technical support brought by the institute to the local commissions of information (C.L.I) in this perspective, both organizations wished beforehand to realize an inquiry on the expectations of the C.L.I. and the I.R.S.N. in follow-up of release and surveillance of the nuclear installations environment. The present document reports objectives and methodology of the inquiry, results obtained notably by underlining the identified problems and the actions suggested to remedy it. (N.C.)

Radiolabelling of isopeptide N epsilon-(gamma-glutamyl)-L-lysine by conjugation with N-succinimidyl-4-[18F]fluorobenzoate.

Science.gov (United States)

Wüst, F; Hultsch, C; Bergmann, R; Johannsen, B; Henle, T

2003-07-01

The isopeptide N(epsilon)-(gamma-glutamyl)-L-lysine 4 was labelled with 18F via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB). A modified approach for the convenient synthesis of [18F]SFB was used, and [18F]SFB could be obtained in decay-corrected radiochemical yields of 44-53% (n = 20) and radiochemical purity >95% within 40 min after EOB. For labelling N(epsilon)-(gamma-glutamyl)-L-lysine with [18F]SFB the effects of isopeptide concentration, temperature, and pH were studied to determine the optimum reaction conditions. The coupling reaction was shown to be temperature and pH independent while being strongly affected by the isopeptide concentration. Using the optimized labelling conditions, in a typical experiment 1.3GBq of [18F]SFB could be converted into 447MBq (46%, decay-corrected) of [18F]fluorobenzoylated isopeptide within 45 min, including HPLC purification.

Inconel 718 süper alaşımının farklı gerilme ve sıcaklıklarda yüksek sıcaklık sürünme davranışının incelenmesi

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Ergün Subaşı

2016-04-01

Full Text Available Bu çalışmada, havacılıkta yaygın olarak kullanılan Inconel 718 süper alaşımının sürünme davranışına sıcaklık ve gerilmenin etkileri incelenmiştir. Deneyler; 750°C, 800°C sıcaklıklarında ve 200-350MPa gerilme aralığında gerçekleştirilmiştir. Deneysel çalışma sonuçlarından, gerilme üssü (n, sürünme hızı (έ ve aktivasyon enerjisi (Q hesaplanmıştır. Hesaplanan sonuçlara göre; sürünme hızlarının artan gerilme ile arttığı, ayrıca sıcaklığın artmasıyla birlikte sürünme hızları çok daha fazla artmaktadır. Aynı şekilde, artan gerilme ile birlikte aktivasyon enerjisi artmaktadır. Deney sonuçlarından elde edilen gerilme üssü değerlerine göre; etkin deformasyon mekanizmasının dislokasyon sürünmesi olduğu tespit edilmiştir. Inconel 718 süper alaşımının kopma sürünme ömrünü tahmin etmek için, Larson Miller grafiği çizilmiştir. Bu grafikle, Inconel 718’in yüksek sıcaklık sürünme ömürleri hesaplanabilir.

Synthesis of racemic, S(+)- and R(-)-N-[methyl- 3H]3,4-methylenedioxymethamphetamine

International Nuclear Information System (INIS)

Hashimoto, Kenji; Hirai, Katsumi; Goromaru, Tsuyoshi

1990-01-01

The synthesis of 3,4-methylenedioxymethampetamine (MDMA), a serotonergic neurotoxin, labeled with tritium is described. Labeling was accomplished by N-alkylation of the free base of the corresponding desmethyl compound using [ 3 H]methyl iodide. The compound was purified by preparative HPLC. The radiochemical yield was about 60% based on [ 3 H]methyl iodide. The radiochemical purity was more than 95% from HPLC and TLC. Furthermore, S(+)- and R(-)-[ 3 H]MDMA were completely separated by analytical HPLC with chiral column. (author)

Santiago H. Valdés, Psicología social : Prolam S. R. L., Colección Ciencias Sociales, Buenos Aires, 1979

OpenAIRE

Rossi Casé, Lilia Elba

1981-01-01

Esta nueva obra de Santiago H. Valdés nos ofrece un panorama considerablemente completo del área que ocupa a la Psicología Social. Su lectura permite en una primera parte, un acercamiento a temas tales cómo la evolución y búsqueda de la Psicología Social, comenzando con un desarrollo acerca de las Ciencias Sociales en general, consideradas por diversos autores, entre ellos Adam Smith, Comte, Max Weber, Durkheim, Horowitz, Hilgard, etc. Luego se adentra en et análisis de la socialización, el l...

Modeling Dynamic Tactical Behaviors in Combatxxi using Hierarchical Task Networks

Science.gov (United States)

2014-06-01

lay , 74 S t r i n g r a n g e I n M e t e r s , 75 S t r i n g dataType , 76 O b j e c t d a t a ) 77 { 78 79 S t r i n g d a t a P l a c e H o l d e...idTime , 214 S t r i n g cance lTime , 215 S t r i n g de lay , 216 S t r i n g r a n g e I n M e t e r s , 217 S t r i n g dataType , 218 O b j e c t...s i f i e r , 227 va l idTime , 228 cance lTime , 229 de lay , 230 r a n g e I n M e t e r s , 231 dataType , 232 d a t a ) ; 233 234 L i s t < S t r

Plasmas pour la destruction de l'H2S et des mercaptans Plasmas for Destruction of H2s and Mercaptans

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Czernichowski A.

2006-12-01

Full Text Available Cet article passe en revue l'utilisation des plasmas comme milieu activateurs d'une oxydation de H2S ou CH3SH dilués dans l'air, le CO2 ou la vapeur d'eau, à fins de conversion en SO, moins malodorant. Le produit peut être ensuite utilisé comme réactif dans un processus similaire à celui de Claus, en présence d'eau, ce qui permet de convertir deux fois plus de polluants initiaux en soufre élémentaire. Une attention particulière est portée aux décharges électriques glissantes (GlidArc. Ces décharges puissantes produisent un plasma non thermique qui active des réactions oxydatrices. La plupart des expériences ont été réalisées en utilisant les réacteurs GlidArc-I à un ou à quatre étages. Les sulfures dilués dans l'air dans des concentrations initiales atteignant jusqu'à 1 %( H2S ou 0,1 % (CH3SH ont été traités sous des flux jusqu'à 70 m3(n/h d'air pollué et sous une puissance de 5 kW. Les essais ont été réalisés sous 1 atm. Une dépollution jusqu'à 100 % a été obtenue moyennant un coût énergétique assez bas dépendant de la concentration initiale du polluant : environ 1000 kWh par kilogramme de soufre extrait pour 100 ppm de H2S et seulement 10 kWh/kg pour 1 % initial d'H2S dans l'air. Pratiquement les mêmes coûts ont été observés dans le cas de mélanges CH3SH-air. En utilisant une très simple douche en recirculation d'eau qui lave les gaz sortants (l'eau se sature avec le SO2 et capture ainsi l'H2S non traité nous avons divisé ces coûts d'énergie par trois, en évitant également l'émission de SO2, et en obtenant du soufre non toxique. Un nouveau principe (et réacteur GlidArc-II est ensuite présenté ; il s'agit d'une brosseà décharges électriques. Nos premiers tests sont très prometteurs car dès à présent, nous divisons déjà la dépense énergétique par deux par rapport au GlidArc-I. L'échelle industrielle peut par conséquent être envisagée. Plasmas are reviewed as activation

Enrichment of variations in KIR3DL1/S1 and KIR2DL2/L3 among H1N1/09 ICU patients: an exploratory study.

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David La

Full Text Available BACKGROUND: Infection by the pandemic influenza A (H1N1/09 virus resulted in significant pathology among specific ethnic groups worldwide. Natural Killer (NK cells are important in early innate immune responses to viral infections. Activation of NK cells, in part, depend on killer-cell immunoglobulin-like receptors (KIR and HLA class I ligand interactions. To study factors involved in NK cell dysfunction in overactive immune responses to H1N1 infection, KIR3DL1/S1 and KIR2DL2/L3 allotypes and cognate HLA ligands of H1N1/09 intensive-care unit (ICU patients were determined. METHODOLOGY AND FINDINGS: KIR3DL1/S1, KIR2DL2/L3, and HLA -B and -C of 51 H1N1/09 ICU patients and 105 H1N1-negative subjects (St. Theresa Point, Manitoba were characterized. We detected an increase of 3DL1 ligand-negative pairs (3DL1/S1(+ Bw6(+ Bw4(-, and a lack of 2DL1 HLA-C2 ligands, among ICU patients. They were also significantly enriched for 2DL2/L3 ligand-positive pairs (PVA, P=0.024, Pc=0.047; Odds Ratio:2.563, CI95%:1.109-5.923, 3DL1*00101 (Ab>VA, PSTh, P=0.034, Pc=0.268, and 3DL1*029 (Ab>STh, P=0.039, Pc=0.301. Aboriginal patients ligand-positive for 3DL1/S1 and 2DL1 had the lowest probabilities of death (R(d (R(d=28%, compared to patients that were 3DL1/S1 ligand-negative (R(d=52% or carried 3DL1*029 (R(d=52%. Relative to Caucasoids (CA, two allotypes were enriched among non-aboriginal ICU patients (NAb: 3DL1*00401 (NAb>CA, P<0.001, Pc<0.001 and 3DL1*01502 (CAS1, 2DL2/L3, and 2DL1 had the lowest probabilities of death (R(d=36%, compared to subjects with 3DL1*01502 (R(d=48% and/or 3DL1*00401 (R(d=58%. CONCLUSIONS: Specific KIR3DL1/S1 allotypes, 3DL1/S1 and 2DL1 ligand-negative pairs, and 2DL2/L3 ligand-positive pairs were enriched among ICU patients. This suggests a possible association with NK cell dysfunction in patients with overactive immune responses to H1N1/09, leading to

Facteurs de risque de mortalité chez les nouveaux-nés transférés au service de néonatologie de l'Hôpital Jason Sendwe de Lubumbashi, République Démocratique du Congo

Science.gov (United States)

Katamea, Tina; Mukuku, Olivier; Kamona, Lewis; Mukelenge, Kethye; Mbula, Otikeke; Baledi, Lambert; Ntambwe, Emile; Mutombo, Augustin Mulangu; Wembonyama, Stanis Okitotsho; Luboya, Oscar Numbi

2014-01-01

Introduction La mortalité néonatale reste préoccupante dans notre milieu et plusieurs facteurs dont ceux liés à l'organisation du transfert de nouveau-nés au niveau des structures de prise en charge y contribuent. Les objectifs de notre étude sont de déterminer la fréquence du transfert néonatal extrahospitalier à l'unité de néonatologie et identifier les facteurs de risque de mortalité dans notre milieu. Méthodes Il s'agit d'une étude prospective et analytique menée sur une période de douze mois allant du 1er Janvier 2012 au 31 décembre 2012 ayant ciblé tous les nouveau-nés transférés des maternités extérieurs, traités et suivis dans le service de néonatologie de l'hôpital Sendwe. Les caractéristiques maternelles (âge, parité, état-civil, profession, niveau d’étude, antécédents médicaux et toxicologiques) et perpartales (âge gestationnel, état de la poche des eaux, voie d'accouchement) et néonataux (âge lors du transfert, sexe, poids de naissance, moyen de transfert, motif de transfert et évolution (guérison ou décès)) ont été étudiés. La saisie et l'analyse des données ont été faites sur le logiciel Epi Info 2011 (version 7.0.8.3) et le seuil de signification de 5%. Résultats La fréquence du transfert néonatal extrahospitalier est de 12,9%. La mortalité était significativement liée à la profession (vendeuse ou travailleuse) de la mère (OR = 7,43 (1,38-39,97)), au niveau d’étude élevé (OR = 4,22 (1,18-15,10)), à l’âge gestationnel sexe masculin du nouveau-né (OR=2,43 (1,08-5,46)), au poids de naissance <1500 grammes (OR=15,3 (5,73-40,78)) et à la prématurité comme motif de transfert (OR=5,56 (1,47-20,98)). Conclusion Le bilan de la mortalité néonatale est lourd dans les pays en développement où les nouveau-nés continuent de mourir pour des causes souvent évitables. La réduction de la morbidité et la mortalité néonatales passe par une amélioration du système de référence des

Caracterización estacional del hábitat fluvial del río Erro (Navarra

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P.M. Leunda, R. Miranda, M.C. Escala

2004-01-01

Full Text Available Se presenta la descripción de catorce tramos representativos del río Erro (Navarra a partir de la caracterización del hábitat fluvial llevada a cabo en invierno, verano y otoño de 2002. Para este estudio se han considerado parámetros tanto del hábitat físico (profundidad, anchura del cauce, pendiente de las orillas, velocidad del agua, tipo de sustrato, vegetación acuática y sombreado como físico-químicos del agua (temperatura, pH, conductividad, sólicos disueltos y oxigeno disuelto. El análisis de las caracteristicas del rio Erro permite considerar su estado general como bueno, aunque se detecta la presencia de un tramo sensible aguas abajo de la localidad de Erro. Si bien este tramo sensible presenta niveles de conservación aceptables, es susceptible de deteriorarse si no de adoptan las medidas oportunas para su conservación. Se sugiere su inclusión en el Lugar de Interés Comunitario (Red Natura 2000 de Navarra de los "Sistemas Fluviales de lis Ríos Irati, Urrobi y Erro".

A study of analysis PB1-F2 protein of Influenza Viruses A/H1N1pdm09, A/ H3N2, and A/H5N1

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Hana Apsari Pawestri

2016-07-01

Full Text Available Abstrak Tujuan. Protein PB1-F2 (polymerase basic 1-frame 2 adalah protein terbaru yang ditemukan pada virus Influenza dan telah terbukti berperan dalam induksi kematian sel dan patogenitas. Tujuan dari tulisan ini adalah untuk menganalisis protein PB1-F2 pada virus Influenza A/H5N1 dan A/H1N1pdm09. Metode. Kami melakukan pencarian data yang relevan yaitu sekuens gen virus Influenza A/H5N1 dan A/H1N1pdm09 dari Gen Bank National Center for Biotechnology Information (NCBI selama tahun 1997-2015. Data yang digunakan adalah data sekuens nukleotida gen PB1 (polymerase basic1 virus influenza A/H5N1 dan A/H1N1pdm09. Kemudian dilakukan analisis alignment untuk mengetahui variasi protein dan mutasi yang berhubungan dengan patogenitas dan virulensi. Hasil. Kami melakukan penelitian terhadap sekuens PB1-F2 sebanyak 3262 influenza A/H5N1 dan 2472 Influenza A/H1N1pdm09. Hasil analisis menunjukkan bahwa semua sekuens A/H5N1 memiliki panjang yang penuh sebanyak 90 asam amino, kecuali influenza pandemi 2009 hanya memiliki panjang 87 asam amino. Kemudian, ditemukan mutasi yang berhubungan dengan virulensi yang ditunjukan dengan perubahan asam amino Asparagin (N menjadi Serin (S. Mutasi tersebut terjadi pada Influenza A/H5N1 sebanyak 8.5% dan Influenza A/H1N1pdm09 sebanyak 0.5%. Kesimpulan. Ditemukan beberapa variasi panjang asam amino dan mutasi penting pada sekuens PB1-F2 dari subtipe yang berbeda yaitu influenza A/H5N1 dan A/H1N1pdm09  yang mengindikasikan seleksi spesifik karena introduksi dan adaptasi terhadap inang yang berbeda. Diperlukan penelitian lanjutan untuk lebih memahami variasi dan kontribusi protein PB1-F2 tersebut terhadap virulensi dan patogenitas virus Influenza. Kata kunci : Patogenesis, Virus Influenza, Protein  PB1-F2 Abstract Aim. Influenza virus PB1-F2 (polymerase basic 1-frame 2 protein is a novel protein previously shown to be involved in cell death induction and pathogenesis. Here we analysis the PB1-F2 protein of Influenza virus A/H

A study of analysis PB1-F2 protein of Influenza Viruses A/H1N1pdm09, A/ H3N2, and A/H5N1

Directory of Open Access Journals (Sweden)

Hana Apsari Pawestri

2016-07-01

Full Text Available Abstrak Tujuan. Protein PB1-F2 (polymerase basic 1-frame 2 adalah protein terbaru yang ditemukan pada virus Influenza dan telah terbukti berperan dalam induksi kematian sel dan patogenitas. Tujuan dari tulisan ini adalah untuk menganalisis protein PB1-F2 pada virus Influenza A/H5N1 dan A/H1N1pdm09. Metode. Kami melakukan pencarian data yang relevan yaitu sekuens gen virus Influenza A/H5N1 dan A/H1N1pdm09 dari Gen Bank National Center for Biotechnology Information (NCBI selama tahun 1997-2015. Data yang digunakan adalah data sekuens nukleotida gen PB1 (polymerase basic1 virus influenza A/H5N1 dan A/H1N1pdm09. Kemudian dilakukan analisis alignment untuk mengetahui variasi protein dan mutasi yang berhubungan dengan patogenitas dan virulensi. Hasil. Kami melakukan penelitian terhadap sekuens PB1-F2 sebanyak 3262 influenza A/H5N1 dan 2472 Influenza A/H1N1pdm09. Hasil analisis menunjukkan bahwa semua sekuens A/H5N1 memiliki panjang yang penuh sebanyak 90 asam amino, kecuali influenza pandemi 2009 hanya memiliki panjang 87 asam amino. Kemudian, ditemukan mutasi yang berhubungan dengan virulensi yang ditunjukan dengan perubahan asam amino Asparagin (N menjadi Serin (S. Mutasi tersebut terjadi pada Influenza A/H5N1 sebanyak 8.5% dan Influenza A/H1N1pdm09 sebanyak 0.5%. Kesimpulan. Ditemukan beberapa variasi panjang asam amino dan mutasi penting pada sekuens PB1-F2 dari subtipe yang berbeda yaitu influenza A/H5N1 dan A/H1N1pdm09  yang mengindikasikan seleksi spesifik karena introduksi dan adaptasi terhadap inang yang berbeda. Diperlukan penelitian lanjutan untuk lebih memahami variasi dan kontribusi protein PB1-F2 tersebut terhadap virulensi dan patogenitas virus Influenza. Kata kunci : Patogenesis, Virus Influenza, Protein  PB1-F2 Abstract Aim. Influenza virus PB1-F2 (polymerase basic 1-frame 2 protein is a novel protein previously shown to be involved in cell death induction and pathogenesis. Here we analysis the PB1-F2 protein of Influenza virus A/H

Probes and their application to the study of H.F. plasmoids; Les sondes et leur application dans l'etude des plasmoides H.F

Energy Technology Data Exchange (ETDEWEB)

Brunet, A; Geller, R [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

1960-07-01

In the first part of this paper, we study the single Langmuir probe and the double-probe method. In the second part, we describe the probe-technique in connection with R.F. plasmoids. (author) [French] Dans la premiere partie de cet article, nous rappelons les principes d'utilisation de la sonde simple de Langmuir ainsi que la methode de la sonde double. La seconde partie est consacree a la pratique des sondes dans l'etude des plasmoides H.F. (auteur)

Testing and Evaluation of a Predeployment Stress Inoculation Training Program (PreSTINT)

Science.gov (United States)

2016-07-01

Armstrong , M. S., Gold, R., O’Connor, N., Jenneke, W., & Tarrier, N. (1994). A trial of eye movement desensitization compared to image habituation...38(9), 113. doi: 10.1007/s10916-014-0113-2 Vaughan, K., Armstrong , M. S., Gold, R., O’Connor, N., Jenneke, W., & Tarrier, N. (1994). A trial of eye...Hypertension, 13, 112S– 122S. Cohen, J. (1992). A power primer. Psychological Bulletin, 112, 155–159. Cohen, H., Kotler , M., Matar, M. A., Kaplan, Z

Radiolabelling of isopeptide N{sup {epsilon}}-({gamma}-glutamyl)-L-lysine by conjugation with N-succinimidyl-4-[{sup 18}F]fluorobenzoate

Energy Technology Data Exchange (ETDEWEB)

Wuest, F; Hultsch, C; Bergmann, R; Johannsen, B; Henle, T

2003-07-01

The isopeptide N{sup {epsilon}}-({gamma}-glutamyl)-L-lysine 4 was labelled with {sup 18}F via N-succinimidyl-4-[{sup 18}F]fluorobenzoate ([{sup 18}F]SFB). A modified approach for the convenient synthesis of [{sup 18}F]SFB was used, and [{sup 18}F]SFB could be obtained in decay-corrected radiochemical yields of 44-53% (n=20) and radiochemical purity >95% within 40 min after EOB. For labelling N{sup {epsilon}}-({gamma}-glutamyl)-L-lysine with [{sup 18}F]SFB the effects of isopeptide concentration, temperature, and pH were studied to determine the optimum reaction conditions. The coupling reaction was shown to be temperature and pH independent while being strongly affected by the isopeptide concentration. Using the optimized labelling conditions, in a typical experiment 1.3 GBq of [{sup 18}F]SFB could be converted into 447 MBq (46%, decay-corrected) of [{sup 18}F]fluorobenzoylated isopeptide within 45 min, including HPLC purification.

Synthesis of racemic, S(+)- and R(-)-N-[methyl- [sup 3]H]3,4-methylenedioxymethamphetamine

Energy Technology Data Exchange (ETDEWEB)

Hashimoto, Kenji; Hirai, Katsumi; Goromaru, Tsuyoshi (Fukuyama Univ. (Japan). Faculty of Pharmacy and Pharmaceutical Sciences)

1990-04-01

The synthesis of 3,4-methylenedioxymethampetamine (MDMA), a serotonergic neurotoxin, labeled with tritium is described. Labeling was accomplished by N-alkylation of the free base of the corresponding desmethyl compound using [[sup 3]H]methyl iodide. The compound was purified by preparative HPLC. The radiochemical yield was about 60% based on [[sup 3]H]methyl iodide. The radiochemical purity was more than 95% from HPLC and TLC. Furthermore, S(+)- and R(-)-[[sup 3]H]MDMA were completely separated by analytical HPLC with chiral column. (author).

Rotational hypersurfaces with $L_r$-pointwise 1-type Gauss map

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Akram Mohammadpouri

2018-07-01

Full Text Available In this paper, we study hypersurfaces in $\\E^{n+1}$ which Gauss map $G$ satisfies the equation $L_rG = f(G + C$ for a smooth function $f$ and a constant vector $C$, where $L_r$ is the linearized operator of the $(r + 1$th mean curvature of the hypersurface, i.e., $L_r(f=tr(P_r\\circ\

androestériles y fértiles

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Baltazar Leovigildo Torres-Ruiz

2007-01-01

Full Text Available Efecto de brasinoesteroides en híbridos de maíz androestériles y fértiles. el obje­ti­vo fue­ de­te­rmi­na­r la­ re­sp­ue­sta­ de­ híbri­dos a­ndroe­stéri­le­s y férti­le­s de­ ma­íz a­nte­ la­ a­p­li­ca­ci­ón de­ bra­si­noe­ste­roi­de­ (ciDeF-4. se­ e­va­lua­ron e­n e­l ca­mp­o exp­e­ri­me­nta­l Va­lle­ de­ méxi­co, e­n e­l ci­clo p­ri­ma­ve­ra­ – ve­ra­no 2004, dos dosis (30 y 60 g/ha de fitohormona con su respectivo te­sti­go e­n 10 ge­noti­p­os, ba­jo un di­se­ño de­ bloque­s comp­le­tos a­l azar. Para la variable rendimiento no hubo diferencia significati­va­ a­l a­p­li­ca­r ciDeF-4 e­n los ge­noti­p­os, e­n e­l a­náli­si­s ge­ne­ra­l donde­ se­ e­ngloba­n los 10 ge­noti­p­os, si­n consi­de­ra­r e­l ti­p­o de­ cruza­s. mi­e­ntra­s que­ a­l e­fe­ctua­r un a­náli­si­s se­p­a­ra­ndo ti­p­os de­ cruza­s, se­ obse­rvó que­ a­l a­p­li­ca­r ciDeF-4 e­n híbri­dos tri­li­- neales fértiles, se tuvieron diferencias altamente significativas, donde­ la­ dosi­s de­ 30 g/ha­ ri­ndi­ó 8.083 t/ha­, re­sp­e­cto a­l te­sti­go cuyo va­lor fue­ 3.858 t/ha­. en ca­mbi­o e­n los híbri­dos tri­li­ne­a­le­s androestériles no se presentaron diferencias significativas para la­s va­ri­a­ble­s e­va­lua­da­s. si­n e­mba­rgo, e­n los híbri­dos de­ cruza­ si­mp­le­ e­n ve­rsi­ón férti­l y a­ndroe­stéri­l e­l bra­si­noe­ste­roi­de­ a­de­- lantó la floración masculina y femenina.

Modifications de l'hémogramme au cours des maladies et affections accompagnées d'anémie chez le chien : étude rétrospective de 1 064 cas observes à l'E.N.V.T. (1997-2001)

OpenAIRE

Felter, Marlène-Laurence

2002-01-01

Notre étude est fondée sur l'analyse de 1064 hémogrammes de chiens anémiés, examinés à la consultation de l'Ecole Nationale Vétérinaire de Toulouse entre 1997 et 2001. Elle nous a permis : - de recenser les principales affections et maladies du chien accompagnées d'anémie. - de décrire les modifications de l'hémogramme au cours de ces troubles. - de dégager l'intérêt et les limites de l'hémogramme pour le diagnostic et le suivi. L'hémogramme, envisagé dans son ensemble, oriente généralement v...

Ripsteg mot spetskunskap i samisk matematik:lärares perspektiv på transformeringsaktiviteter i samisk förskola och sameskola

OpenAIRE

Jannok-Nutti, Ylva

2010-01-01

Syftet med föreliggande avhandling är att utifrån lärarperspektiv beskriva, analysera och försöka förstå transformering av utbildning i matematik så att ett samiskt perspektiv blir utgångspunkt för utbildningen. Avhandlingen genomfördes såsom ett aktionsforskningsprojekt med fokus på lärares perspektiv avseende transformering och genomförande av transformeringsaktiviteter i matematik. Teoretiska utgångspunkter togs utifrån Smiths teori om urfolksperspektiv, Banks teori för integrering av mult...

Taxonomi för databashanterare

OpenAIRE

Österberg, Alexander

2017-01-01

Syftet med denna undersökning är att ta fram en taxonomi för databashanteringssystem (DBMS) som kan förenkla valet av DBMS, då det kan vara en lång och komplicerad process. Taxonomin klassificerar kriterier hos DBMS som anses viktiga i en litteraturstudie av flertalet artiklar. Arbetet visar även på en strukturerad process för att gå från krav till val av databashanterare i form av ett poängsystem som använder sig av taxonomin och DBMS rangordning på olika kriterier. Valprocessen tar ställnin...

Caracterización fármaco-toxicológica de la planta medicinal Sambucus nigra subsp. canadensis (L. R. Bolli Pharmaceutical-toxicological characterization of medicinal plant Sambucus nigra subsp. canadensis (L. R. Bolli

Directory of Open Access Journals (Sweden)

Oneyda Clapé Laffita

2011-12-01

Full Text Available El objetivo de la monografía consistió en la caracterización fármaco-toxicológica de Sambucus nigra subsp. canadensis (L. R. Bolli, planta tradicional cubana con actividad antiinflamatoria, entre otras. Se presentan aspectos farmacológicos como composición fitoquímica, propiedades atribuidas popularmente y comprobadas científicamente, posología, reacciones adversas, advertencias, interacciones, toxicidad, precauciones y contraindicaciones. Se concluye que con la monografía fármaco-toxicológica de esta planta medicinal, se dispone de una completa información, como documentación indispensable para actualizar las bases de datos nacionales e internacionales al respecto, con vistas a desarrollar nuevos fitofármacos, en especial antiinflamatorios con bajo potencial de efectos adversos.The objective of the monograph was the pharmacological and toxicological characterization of Sambucus nigra subspecies canadensis(L. R. Bolli, a Cuban traditional plant with anti-inflammatory action, among others. Several pharmacological aspects such as phytochemical composition; scientifically tested properties attributed by the population; posology; adverse reactions; warnings; interactions; toxicity; precautions and counterindications were presented. It was concluded that the pharmaceutical and toxicological monograph of this plant provides full information as indispensable documentation to update national and international databases, with a view to developing new pharmaceuticals, particularly anti-inflammatory drugs with low adverse effect potential.

Başarılı ve Başarısız Dördüncü Sınıf Okuyucularının Okuduğunu Anlama ve Özetleme Becerileri.

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Zeynep Bahap Kudret

2016-12-01

Full Text Available Bu çalışmada okumada başarılı olan ve olmayan öğrencilerin okuduğunu anlama ve özetleme becerilerinin karşılaştırmalı olarak incelenmesi amaçlanmıştır. Çalışmada, öğrencilerin yazılı özetlerindeki biçimbirimbilgisi/sözdizimi [Ortalama Sözce Uzunlukları (OSU] ve sözcük dağarcıkları da [Farklı Sözcük Sayısı (FSÖZS] karşılaştırılmıştır. Ayrıca, okuduğunu anlama puanları, özetleme puanları, OSU ve FSÖZS arasındaki ilişkiler incelenmiştir. Bu amaçla, 122 başarılı ve 122 başarısız okuyucu olmak üzere, toplam 244 dördüncü sınıf öğrencisi araştırmaya katılmıştır. Bulgular, zayıf okuyucuların tüm soru türlerini yanıtlamada akranlarından daha başarısız olduklarını göstermiştir. Bununla birlikte, her iki gruptaki öğrencilerin de en çok ana düşünceyi bulma ile kişisel bilgi ve deneyimlerini kullanarak çıkarım yapma sorularında güçlük çektikleri belirlenmiştir. Zayıf okuyucuların özetlemenin tüm alt becerilerinde, ayrıca OSU ve FSÖZS ölçümlerinde akranlarından daha fazla güçlüğe sahip oldukları görülmüştür. Özetleme, biçimbirimbilgisi/sözdizimi (OSU ve sözcük dağarcığı (FSÖZS değişkenlerinin okuduğunu anlama üzerindeki etkisi incelendiğinde, biçimbirimbilgisi/sözdiziminin okuduğunu anlamayı en iyi yordayan değişken olduğu bulunmuştur. In this study, it was aimed to examine reading comprehension and summarizing skills of successful and unsuccessful students in reading comparatively. Their morphosyntax knowledge (Mean Length of UtteranceMLU and vocabulary knowledge (Different Words Used-DWU in their written summaries were also compared in the study. In addition, the relations between their reading comprehension scores, summarizing scores, MLU and DWU were examined. For this purpose, 122 successful and 122 unsuccessful readers, totally 244 fourth graders participated in the study. Findings showed that poor

A Study on L-Asparaginase of Nocardia levis MK-VL_113

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Alapati Kavitha

2012-01-01

Full Text Available An enzyme-based drug, L-asparaginase, was produced by Nocardia levis MK-VL_113 isolated from laterite soils of Guntur region. Cultural parameters affecting the production of L-asparaginase by the strain were optimized. Maximal yields of L-asparaginase were recorded from 3-day-old culture grown in modified asparagine-glycerol salts broth with initial pH 7.0 at temperature 30∘C. Glycerol (2% and yeast extract (1.5% served as good carbon and nitrogen sources for L-asparaginase production, respectively. Cell-disrupting agents like EDTA slightly enhanced the productivity of L-asparaginase. Ours is the first paper on the production of L-asparaginase by N. levis.

Radiolabelling of isopeptide Nε-(γ-glutamyl)-L-lysine by conjugation with N-succinimidyl-4-[18F]fluorobenzoate

International Nuclear Information System (INIS)

Wuest, F.; Hultsch, C.; Bergmann, R.; Johannsen, B.; Henle, T.

2003-01-01

The isopeptide N ε -(γ-glutamyl)-L-lysine 4 was labelled with 18 F via N-succinimidyl-4-[ 18 F]fluorobenzoate ([ 18 F]SFB). A modified approach for the convenient synthesis of [ 18 F]SFB was used, and [ 18 F]SFB could be obtained in decay-corrected radiochemical yields of 44-53% (n=20) and radiochemical purity >95% within 40 min after EOB. For labelling N ε -(γ-glutamyl)-L-lysine with [ 18 F]SFB the effects of isopeptide concentration, temperature, and pH were studied to determine the optimum reaction conditions. The coupling reaction was shown to be temperature and pH independent while being strongly affected by the isopeptide concentration. Using the optimized labelling conditions, in a typical experiment 1.3 GBq of [ 18 F]SFB could be converted into 447 MBq (46%, decay-corrected) of [ 18 F]fluorobenzoylated isopeptide within 45 min, including HPLC purification

Ryger troværdigheden ned, når vi taler læreruddannelsen op?

DEFF Research Database (Denmark)

Holm, Claus

2009-01-01

Nu er vi ved at få talt læreruddannelsen op af sin lavstatus. Resultatet er, at flere søger uddannelsen. Så må vi håbe, at talen er troværdig, for ellers vil frafaldet stige.......Nu er vi ved at få talt læreruddannelsen op af sin lavstatus. Resultatet er, at flere søger uddannelsen. Så må vi håbe, at talen er troværdig, for ellers vil frafaldet stige....

Balans mellan arbete och familjeliv : Ett vinnande koncept för alla

OpenAIRE

Holmgren, Viktor; Ajena, David

2012-01-01

Under de senaste årtionden har en stor förändring skett hos familjers olika sätt att förhålla sig till arbetslivet. Den traditionella arbetsdagen på 8-timmar är inte längre normen, och den framväxande informations- och kommunikations teknologin gör att en anställd kan få tillgång till allt arbete 24/7. En följd av dessa förändringar är att efterfrågan på familjerelaterande- och hushållsnäratjänster har ökat både för män och kvinnor. Rapporten har visat forskning och studier som påvisar att de...

Crystal Structure of the 23S rRNA Fragment Specific to r-Protein L1 and Designed Model of the Ribosomal L1 Stalk from Haloarcula marismortui

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Azat Gabdulkhakov

2017-02-01

Full Text Available The crystal structure of the 92-nucleotide L1-specific fragment of 23S rRNA from Haloarcula marismortui (Hma has been determined at 3.3 Å resolution. Similar to the corresponding bacterial rRNA fragments, this structure contains joined helix 76-77 topped by an approximately globular structure formed by the residual part of the L1 stalk rRNA. The position of HmaL1 relative to the rRNA was found by its docking to the rRNA fragment using the L1-rRNA complex from Thermus thermophilus as a guide model. In spite of the anomalous negative charge of the halophilic archaeal protein, the conformation of the HmaL1-rRNA interface appeared to be very close to that observed in all known L1-rRNA complexes. The designed structure of the L1 stalk was incorporated into the H. marismortui 50S ribosomal subunit. Comparison of relative positions of L1 stalks in 50S subunits from H. marismortui and T. thermophilus made it possible to reveal the site of inflection of rRNA during the ribosome function.

”Kalle, du kan ju läsa!” Förskoleklasslärare synliggör förskoleklasselevers skriftspråksutveckling

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Tarja Alatalo

2017-03-01

Full Text Available Den här studien tar sin utgångspunkt i ett kompetensutvecklingsprojekt där lärare i förskoleklass gavs möjlighet att genom erfarenhet i handling samt reflektion stärka sina ämneskunskaper inom skriftspråksområdet. Sju lärare i förskoleklass intervjuades om sina erfarenheter i samband med bedömning av elevers skriftspråksutveckling. Studiens syfte var att undersöka vilket meningsskapande som enligt lärarna sker i samband med bedömningsaktiviteten. Fokus riktades mot lärarnas beskrivningar av det egna, men också elevernas meningsskapande. Studiens grund i sociokulturell teori och pragmatismens begrepp, erfarenhet och meningsskapande som centrala analysverktyg, synliggjorde lärarnas fördjupade förståelse för elevers skriftspråksutveckling. I materialet framträder en bild av att tidigare erfarenheter omvärderades och användes tillsammans med nya erfarenheter för att skapa ny kunskap hos både lärare och elever. Exempelvis beskriver lärare hur elever i samband med bedömningsaktiviteten upptäckte att de kunde läsa. I mötet mellan projektets ämnesfokus och praktisk handling kunde lärarna omvärdera tidigare erfarenheter och upptäcka att elever i förskoleklassen läser, hur de läser och hur de själva kan stimulera eleverna vidare. Studiens avsikt är att öppna för en diskussion om hur kompetensutveckling om skriftspråksutveckling kan öka förskoleklasslärares möjligheter att stimulera elever vidare och öka elevernas förutsättningar att utvecklas i riktning mot skolans kunskapskrav.

A calorimetric and equilibrium investigation of the reaction {l_brace}methyl ferulate(aq) + H{sub 2}O(l) = methanol(aq) + ferulic acid(aq){r_brace}

Energy Technology Data Exchange (ETDEWEB)

Goldberg, Robert N., E-mail: robert.goldberg@nist.go [Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20876 (United States); Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250 (United States); Lang, Brian E., E-mail: brian.lang@nist.go [Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20876 (United States); Selig, Michael J., E-mail: michael.selig@nrel.go [National Renewable Energy Laboratory, Biosciences Center, 1617 Cole Boulevard, Golden, CO 80401 (United States); Decker, Stephen R., E-mail: steve.decker@nrel.go [National Renewable Energy Laboratory, Biosciences Center, 1617 Cole Boulevard, Golden, CO 80401 (United States)

2011-03-15

Microcalorimetry and high-performance liquid chromatography (HPLC) have been used to conduct a thermodynamic investigation of the reaction: {l_brace}methyl ferulate(aq) + H{sub 2}O(l) = methanol(aq) + ferulic acid(aq){r_brace}, as catalyzed by feruloyl esterase. Values of the apparent equilibrium constant K' = (29.6 {+-} 0.7) (T = 298.15 K, citrate buffer at pH 4.98, ionic strength I = 0.39 mol {center_dot} kg{sup -1}) and of the calorimetrically determined enthalpy of reaction {Delta}{sub r}H(cal) = (4.0 {+-} 0.9) kJ {center_dot} mol{sup -1} (T = 298.15 K and citrate buffer at pH 4.81, I = 0.36 mol {center_dot} kg{sup -1}) were measured. A chemical equilibrium model, together with pKs and standard enthalpies of reaction {Delta}{sub r}H{sup 0} for the H{sup +}(aq) binding reactions of the reactants and products, was then used to calculate the values K = (1.89 {+-} 0.06) . 10{sup -4}, {Delta}{sub r}H{sup o} = (7.3 {+-} 1.7) kJ {center_dot} mol{sup -1}, {Delta}{sub r}G{sup o} = (21.25 {+-} 0.07) kJ {center_dot} mol{sup -1}, and {Delta}{sub r}S{sup o} = - (46.8 {+-} 5.7) J {center_dot} K{sup -1} {center_dot} mol{sup -1} for the chemical reference reaction {l_brace}methyl ferulate(aq) + H{sub 2}O(l) = methanol(aq) + ferulic acid{sup -}(aq) + H{sup +}(aq){r_brace}. These values of K and {Delta}{sub r}H{sup o} are similar in magnitude to the corresponding values reported for the reaction {l_brace}propyl gallate(aq) + H{sub 2}O(l) = 3,4,5-trihydroxybenzoic acid{sup -}(aq) + 1-propanol(aq) + H{sup +}(aq){r_brace}. The results obtained in this study can be used in a chemical equilibrium model to calculate how K' and other standard transformed properties such as the standard transformed enthalpy {Delta}{sub r}H'{sup o}, standard transformed Gibbs free energy {Delta}{sub r}G'{sup o}, and the change in binding of H{sup +}(aq), {Delta}{sub r}N(H{sup +}), vary with the independent variables T, pH, and I.

Mindfulness – en metod för studerande : En systematisk litteraturstudie

OpenAIRE

Evatt, Maria

2014-01-01

I detta examensarbete undersöktes mindfulness inom högskole- och universitets studerande. Studerande har visats ha ett behov av verktyg för att hantera stress och för stärkande av studieförmågan under skolgången. Mindfulness är en form av tillvaro och medveten närvaro. Tidigare forskning har visat goda resultat och effekter inom målgrupper såsom t.ex. stresshantering och hälsa. Tillsvidare har ännu lite forskning utförts inom området mindfulness och studerande. Ämnet mindfulness undersöktes d...

HÂRİCÎ LERİN “EL-EMRU Bİ’L-MA’RÛF VE’N-NEHYU ANİ’L-MÜNKER” ANLAYIŞI

OpenAIRE

Dalkıran, Sayın

2010-01-01

“El-Emru bi’l-ma’rûf ve’n-nehyu ani’l-münker / iyiliği emretmek kötülükten sakındırmak” prensibi İslam’da büyük bir öneme sahiptir. Bu bir görevdir ve her müslümanın yapması gereken bir emirdir. Ancak ilk dönemden günümüze kadar bu emrin yerine getirilmesi konusunda Müslüm...

Effects of the Monoamine Uptake Inhibitors RTI-112 and RTI-113 on Cocaine- and Food-Maintained Responding in Rhesus Monkeys

Science.gov (United States)

SS, Negus; NK, Mello; HL, Kimmel; LL, Howell; FI, Carroll

2009-01-01

Cocaine blocks uptake of the monoamines dopamine, serotonin and norepinephrine, and monoamine uptake inhibitors constitute one class of drugs under consideration as candidate “agonist” medications for the treatment of cocaine abuse and dependence. The pharmacological selectivity of monoamine uptake inhibitors to block uptake of dopamine, serotonin and norepinephrine is one factor that may influence the efficacy and/or safety of these compounds as drug abuse treatment medications. To address this issue, the present study compared the effects of 7-day treatment with a non-selective monoamine uptake inhibitor (RTI-112) and a dopamine-selective uptake inhibitor (RTI-113) on cocaine- and food-maintained responding in rhesus monkeys. Monkeys (N=3) were trained to respond for cocaine injections (0.01 mg/kg/inj) and food pellets under a second-order schedule [FR2(VR16:S)] during alternating daily components of cocaine and food availability. Both RTI-112 (0.0032–0.01 mg/kg/hr) and RTI-113 (0.01–0.056 mg/kg/hr) produced dose-dependent, sustained and nearly complete elimination of cocaine self-administration. However, for both drugs, the potency to reduce cocaine self-administration was similar to the potency to reduce food-maintained responding. These findings do not support the hypothesis that pharmacological selectivity to block dopamine uptake is associated with behavioral selectivity to decrease cocaine- vs. food-maintained responding in rhesus monkeys. PMID:18755212

A coexistence curve equation for refrigerant-F-113 within the vicinity of the critical point

International Nuclear Information System (INIS)

Al'okhyin, O.D.; Bezruchko, Yi.V.; Bulavyin, L.A.

2003-01-01

The experimental data on the dependence of the density on temperature have been presented for refrigerant F-113 along the coexistence curve within the wide temperature range including the close vicinity of the critical temperature. The extended equation of state for freon-113 along this direction has been proposed on the base of the van der Waals model of a fluctuation gas. Parameters of the equation is determined by the interaction of molecules inside density fluctuations at the distances r>R c and by the interaction between fluctuations at the distances r>R c (R c is the correlation radius of the system)

Handelsbankens användande av CRM -Är det lönsamt?

OpenAIRE

Salman Kanbar, Ahmad

2012-01-01

Frågeställning: På vilket sätt används CRM av Handelsbanken och hur påverkar det bankens lönsamhet? Syfte: Syftet med detta arbete är att kunna öka kunskapen om hur Handelsbanken tillämpar CRM och för att undersöka om användandet av CRM i bankens verksamhet är lönsamt eller inte. Metod: För att svara på studiens syfte blev en intervju utförd med Handelsbanken. Ännu en anledning till varför en intervju gjordes var på grund av att det var nödvändigt för att få det primärdata som behövdes och fö...

Kriz Dönemlerinde Türk Bankacılık Sektörünün Toplam Faktör Verimlilik Değişimi

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Ferda Keskin Önen

2016-10-01

Full Text Available Bankaların etkinliğini arttırabilmenin ön koşulu rekabet edilebilirliktir. Rekabet gücü yüksek bankacılık sektörü ile ekonomik dinamizm arttırılır ve ekonomik istikrar ortamı sağlanır. Makro ekonomik koşullardaki değişim, bankacılık sektörünün performansını ve finansal istikrarı etkilemektedir. Bu çalışmada 1990 - 2012 döneminde faaliyet gösteren 19 mevduat bankasının aracılık ve karlılık yaklaşımına göre etkinliklerini analiz etmek için Malmquist Verimlilik Endeksi kullanılmıştır. Bankalar, kriz dönemlerinde her iki yaklaşıma göre de verimlilik kaybı yaşamıştır. Kriz sonrası dönemde karlılık yaklaşımına göre büyük ölçekli bankaların verimlilik kaybının daha düşük olduğu görülmektedir. Bankaların aracılık fonksiyonunun etkinliği; bankacılık sektörü yeniden yapılandırma programı dahilinde yapılan regülasyonlar ve dezenflasyon süreci dolayısıyla artmıştır. Bankalar, kriz dönemlerinde her iki yaklaşıma göre de verimlilik kaybı yaşamıştır. karlılık yaklaşımına göre büyük ölçekli bankaların verimlilik kaybının kriz sonrası dönemde daha düşük olduğu görülmektedir. bankacılık sektöründe aracılık fonksiyonunun etkinliği; bankacılık sektörü yeniden yapılandırma programı dahilinde yapılan regülasyonlar ve dezenflasyon süreci dolayısıyla artmıştır. Regresyon analizi sonuçları; mevduatın krediye dönüşüm oranı, ROA, ROE ve TUFE oranının bankaların toplam faktör verimliliğine etkisinin pozitif olduğunu göstermektedir. Aracılık yaklaşımına göre ROE artınca, bankaların toplam faktör verimliliği azalmıştır. Aracılık ve karlılık yaklaşımına göre GSYH oranındaki artış bankaların teknik etkinliklerinde artışa yol açmıştır.

Omsättning, rörelseresultat och kapitalstruktur – Påverkas företags kapitalstruktur av förändringar i dess omsättning eller rörelseresultat?

OpenAIRE

Lisstorp, Mattias; Steinberger, Paul

2012-01-01

Syftet med uppsatsen är att undersöka hur omsättning och rörelseresultat har samband med företagets kapitalstruktur. Resultaten jämförs med befintlig teori för att verifiera de teoretiska ansatserna. Regressionsanalys av tidsserier för 32 svenska börsnoterade företag med mer än 20 miljarder svenska kronor i omsättning 2010 har använts vid den här undersökningen. Data från åren 2004 till 2010 till varje företag är tagen från databasen ”Affärsdata” och undersöks genom regressionsanalys. Först u...

Profil épidémiologique de l'insuffisance rénale terminale à l'hôpital Militaire de Rabat, Maroc

Science.gov (United States)

Asserraji, Mohammed; Maoujoud, Omar; Belarbi, Marouane; Oualim, Zouhir

2015-01-01

L'Insuffisance rénale chronique terminale (IRCT) est un enjeu majeur de sante publique au Maroc à cause de ses conséquences médicales et socioéconomiques. L'objectif de ce travail est d’évaluer le profil épidémiologique de l'IRCT à l'hôpital militaire de rabat, Maroc. Il s'agit d'une enquête rétrospective pendant quatre ans (1er janvier 2007 au 31 décembre 2010). Tous les cas d'IRCT (diminution permanente du débit de filtration glomérulaire (DFG) < 15 ml/min/1.73m2, pendant ≥ 3 mois) ont été inclus. 203 patients ont commencé la dialyse durant cette période, 130 hommes (64%) et 73 femmes (36%), l’âge moyen était de 49,92 ans (06 - 80 ans). la néphropathie d'origine indéterminée représente la première cause d'IRCT dans notre série (27,1%) suivie de la néphropathie diabétique (24,6%), des glomérulonéphrites chroniques (22,7) et de la néphropathie d'origine vasculaire (10,8%). 131 patients (64,5%) n'ont pas eu de suivi néphrologique pré dialytique. une prise en charge globale de cette pathologie est nécessaire. PMID:26309471

COMPARATIVE STUDY OF CLINICAL OUTCOME OF ARTHROSCOPIC ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION BONE PATELLAR TENDON BONE GRAFT V/S HAMSTRING GRAFT

Directory of Open Access Journals (Sweden)

Priyank

2015-08-01

Full Text Available BACKGROUND: Anterior cruciate ligament is an intra - articular, extra synovial structure present in the central complex of knee joint. It functions in concert with all ot her anatomical structures in the knee joint to control and limit motion and to maintain both static and dynamic equilibrium. It is commonly injured in athletic activities specially contact sports and motor vehicle accidents. Ligament disruption occurs with out a fall or direct contact where deceleration along with valgus external rotation or hyper extension force comes into play. T h e a im o f s u r g ical tre a tme n t is to rest o r e k n e e st ab i l it y , t he re b y a l l o w ing t h e pa ti e n t to return to h is o r ig in a l ph y sical a ct i v i t y l e v e ls. T h e c h o ice o f g r a f t a n d its f i x a ti o n p la y s a k e y role in ACL re c on st r u cti o n. A n id ea l g ra f t w ou ld b e o n e t h a t p ro v id e s a s m u ch stre n g th a s n a ti v e an t e r i o r c r u cia t e l ig am e n t, a l l o w s f o r s e c u re f i x a t i on , h a s m inimal ha r v e st site mo rbidit y , e n a b les u n restr i ct e d re h ab i l it a t i o n a n d rest o res no r ma l k n e e b iomec h a n ics a n d ki ne ma tics. A I M : T o a s s e ss t h e e f fe ct iv ene ss o f t h e bo n e - p a t e l l a r t e n do n - b on e g raft c om p a red to ha m str i n g t endo n g r a f t a s u s e d in t h e tr e a t me n t o f an t e r i o r c r u ci a te li g a m en t in j u r i e s o f t h e k n ee . DESIGN : This is a prospective study. MATERIALS AND METHODS : This prospective study was conducted at a tertiary hospital for a pe r io d o f t w e l v e m on t h s f rom June 2013 t o July 2 014 . Patients presenting with unilateral knee injury in Outpatient depa rtment and Casualty of the hospital were evaluated by a thorough general and local clinical examination of the knee. Uninjured knees of same subjects in supine position were taken as reference. Subjects

Disentangling the f(R). Duality

International Nuclear Information System (INIS)

Broy, Benedict J.; Westphal, Alexander; Pedro, Francisco G.; Univ. Autonoma de Madrid

2014-11-01

Motivated by UV realisations of Starobinsky-like inflation models, we study generic exponential plateau-like potentials to understand whether an exact f(R)-formulation may still be obtained when the asymptotic shift-symmetry of the potential is broken for larger field values. Potentials which break the shift symmetry with rising exponentials at large field values only allow for corresponding f(R)-descriptions with a leading order term R n with 1 2 -term survives as part of a series expansion of the function f(R) and thus cannot maintain a plateau for all field values. We further find a lean and instructive way to obtain a function f(R) describing m 2 φ 2 -inflation which breaks the shift symmetry with a monomial, and corresponds to effectively logarithmic corrections to an R+R 2 model. These examples emphasise that higher order terms in f(R)-theory may not be neglected if they are present at all. Additionally, we relate the function f(R) corresponding to chaotic inflation to a more general Jordan frame set-up. In addition, we consider f(R)-duals of two given UV examples, both from supergravity and string theory. Finally, we outline the CMB phenomenology of these models which show effects of power suppression at low-l.

Okul Öncesi Öğretmenlerin Sınıf İçi Etkinliklerde Kullandıkları Sınıf Yönetimi Stratejilerinin İncelenmesi

OpenAIRE

AKGÜN, Ege; YARAR, Melike; DİNÇER, Çağlayan

2016-01-01

Öğretmenlerin sınıf yönetimi stratejileri, eğitim öğretim etkinliklerinin sağlıklı yürütülmesinde, çocukların akademik ve sosyal başarılarının artmasında ve çocukların yaşam becerileri kazanmasında önemli yer tutmaktadır. Bu araştırmanın amacı, okul öncesi öğretmenlerinin sınıf içi etkinliklerde kullandıkları sınıf yönetimi stratejilerinin gözlem yoluyla incelenmesidir. Araştırmanın çalışma grubunu, Ankara il merkezinde çalışan altı okul öncesi öğretmeni oluşturmaktadır. Okul öncesi öğretmenl...

Pärt: Collage sur B-A-C-H für Kammerorschester / Hans-Christian Dadelsen

Index Scriptorium Estoniae

Dadelsen, Hans-Christian

1993-01-01

Uuest heliplaadist "Pärt: Collage sur B-A-C-H für Kammerorschester, Summa (1991) für Streichorchester, Fratres, Sinfonie Nr. 2, Festina lente, Wenn Bach Bienen gezüchtet hätte, Credo für Klavier, Chor und Orchester. Philharmonia Orchestra and Chorus, Neeme Järvi". Chandos/Koch CD 9134 (WD: 63'02")

X-ray diffraction using synchrotron radiation on the G.I.L.D.A. beam line at the E.S.R.F

Energy Technology Data Exchange (ETDEWEB)

Balerna, A [INFN, Laboratori Nazionali di Frascati, Rome (Italy); Meneghini, C [INFN, Laboratori Nazionali di Frascati, Rome (Italy); [INFM, Genoa (Italy); Bordoni, S [Rome Univ. ` Tor Vergata` (Italy). Dip. di Fisica; Mobilio, S [Rome Univ. III (Italy). Dip. di Fisica ` E. Amaldi`

1996-09-01

The aim of this lecture is to make a short introduction on Synchrotron radiation, its history and main properties. The main components of a synchrotron radiation beam line will be described. The Italian beam line, General purpose Italian beam line Line for Diffraction and Absorption (G.I.L.D.A.) at the European Synchrotron Radiation Facility (E.S.R.F.) in Grenoble will be used as an example. The G.I.L.D.A. diffractometer will be described in detail reporting also some experimental results.

Usûlî Kıyasın Bilgi ve Amel Değeri

Directory of Open Access Journals (Sweden)

Yrd.Doç.Dr. Temel Kacır

2016-06-01

Full Text Available “Ortak bir illete sahip olmaları nedeniyle, aslın hükmünün fer‘e verilmesidir" şeklinde tanımlanan usûlî kıyasın bilgi ve amel değeri, ilk dönemden itibaren tartışma konusu olmuştur. Şöyle ki; hüküm verme yetkisi sadece Şar‘î’e ait olduğu halde usûlî kıyasın dinde hüküm verme anlamına geldiği ve bilgi değerinin de nasslarca yerilmiş zan olduğu gibi bazı argümanlar ileri sürerek usûlî kıyası reddedenler olsa da, çoğunluk tarafından usûlî kıyas aslî ve şer‘î delil olarak kabul edilmiş ve elde edilen bu hüküm ile amel edilmesi gerekli görülmüştür. Bu çalışma, usûlî kıyası kabul eden ve etmeyenlerin görüşlerini mukayese etmenin ötesinde, usûlî kıyasın salt aklî bir çaba olmadığını, kendisi ile ulaşılan bilginin naslarda yerilen zan olmayıp aksine delile dayalı zannın en üst derecesi olduğunu ve bunun da furû fıkıhta amel için yeterli olduğunu naklî ve aklî deliller ile ele alan bir çalışmadır. Kıyasla ilgili genel bir çerçeve çizildikten sonra, usûlî kıyas ve deliller hiyerarşisindeki yeri ve kıyasın bilgi ve amelî değeri ile sınırlandırılan bu makale ile usûlî kıyasın bilgi ve amel değeri konusundaki tartışmalara açıklık getirilmek istenmektedir.

S201 Catalog of Far-Ultraviolet Objects. Revised.

Science.gov (United States)

1982-05-06

0 (pz r -r -r .r Sr -r -r 0 0 0 i t. 0i n Si n i Zr t0I In i l W tD 0 i 4~ -- MMMMMMS S oflor ZZ r-onInculp0 r m0 _ 0m W r r 0r- r-2r w m m - 0 w m...CARRUTHERS, AND HECKATHORN ww o22:w-p o 0> La0 -2 W~ ~ --- M-!l~f~ulj W -- l.- 0~* z. Z (L La LaJ (’uH flJ M m-flm~l N -- u M CL 000 0000 0000 0 0 0...2 f0 n.. M 2~ 0~n T 2 0MgFn flj - i m -rV f MNfuf r r 0 2 U 1 0 o 1 0 0 0 CO T JM ) M0t, ZLa 0 m2 m00 nj~nIO - - ~ - a0> 0 In 0 0 L. c" fl. in ( r

Ramstein AB (Germany, F.R.) Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F

Science.gov (United States)

1985-05-01

All other editions ere obsolete. 22b TELEPHONE 0nc/ude Are« Code ) (610) 256-2625 22( OFFICE SYMBOL USAFETAC/LDD SECURITY CLASSIFICATION OF ’HIS...lii isaia bt&l TOTAL NUMIE« 3F 0«S»VATIONS 913_ ■V <?’’■... J f. H r : T » : PERCENTAGf fR.QUENCY OF WIND 0’R!:CV(ON! AND SPEED (FROM HOURLY

F(R Gravity’s Rainbow and Its Einstein Counterpart

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S. H. Hendi

2016-01-01

Full Text Available Motivated by UV completion of general relativity with a modification of a geometry at high energy scale, it is expected to have an energy dependent geometry. In this paper, we introduce charged black hole solutions with power Maxwell invariant source in the context of gravity’s rainbow. In addition, we investigate two classes of F(R gravity’s rainbow solutions. At first, we study energy dependent F(R gravity without energy-momentum tensor, and then we obtain F(R gravity’s rainbow in the presence of conformally invariant Maxwell source. We study geometrical properties of the mentioned solutions and compare their results. We also give some related comments regarding thermodynamical behavior of the obtained solutions and discuss thermal stability of the solutions.

Effekten av styrketräning kan begränsas mer av samtidig högintensiv intermittent aerob träning än av lågintensiv kontinuerlig aerob träning

OpenAIRE

Jutman, Magnus

2012-01-01

Introduktion Utifrån tidigare forskning har en modell föreslagits som beskriver att lågintensiv aerob uthållighetsträning ska ha mindre negativ påverkan på effekten av styrketräning jämfört med högintensiv aerob uthållighetsträning. Detta påstående har funnit visst stöd i litteraturen men vidare forskning krävs för att det ska kunna fastställas. Syfte Denna studie syftar till att undersöka ifall det föreligger någon skillnad mellan högintensiv aerob intermittent löpträning och lågintensiv aer...

Norges Landsprofil : – En guide för privatpersoner

OpenAIRE

Högnabba, Linda-Mari; Nabb, Johan

2010-01-01

Norge är ett mycket attraktiv land för den arbetssökande som vill pröva på något nytt och få arbetserfarenhet inom olika yrken. Folk från Finland har sedan länge tillbaka åkt till Norge för att tjäna mer pengar och det har många också lyckats med. I detta arbete behandlas de svårigheter och problem som eventuellt kan uppkomma samt hur man skall gå tillväga när man ansöker eller fått anställning. Vi tar även upp problem som kan uppstå vid en eventuell återkomst till Finland eller om man fast b...

The statistical properties of 111,112,113Sn studied with the Oslo method

Science.gov (United States)

Tveten, G. M.; Bello Garrote, F. L.; Campo, L. C.; Eriksen, T. K.; Giacoppo, F.; Guttormsen, M.; Görgen, A.; Hagen, T. W.; Hadynska-Klek, K.; Klintefjord, M.; Larsen, A. C.; Maharromova, S.; Nyhus, H. T.; Renstrøm, T.; Rose, S.; Sahin, E.; Siem, S.; Tornyi, T. G.

2015-05-01

The γ-ray strength function and level density of 111, 112, 113Sn are being studied at the Oslo Cyclotron Laboratory (OCL) up to the neutron binding energy by applying the Oslo method to particle-γ coincidence data. The preliminary results for the γ-ray strength function are discussed in the context of the results for the more neutron-rich Sn-isotopes previously studied at OCL.

Reconstructing a f ( R ) theory from the α-Attractors

Energy Technology Data Exchange (ETDEWEB)

Miranda, T.; Fabris, J. C.; Piattella, O. F., E-mail: tays.andrade@aluno.ufes.br, E-mail: oliver.piattella@pq.cnpq.br, E-mail: fabris@pq.cnpq.br [Department of Physics, Universidade Federal do Espírito Santo, avenida Fernando Ferrari 514, 29075-910 Vitória, Espírito Santo (Brazil)

2017-09-01

We show an analogy at high curvature between a f ( R ) = R + aR {sup n} {sup −} {sup 1} + bR {sup 2} theory and the α-Attractors. We calculate the expressions of the parameters a , b and n as functions of α and the predictions of the model f ( R ) = R + aR {sup n} {sup −} {sup 1} + bR {sup 2} on the scalar spectral index n {sub s} and the tensor-to-scalar ratio r . We find that the power law correction R {sup n} {sup −} {sup 1} allows for a production of gravitational waves enhanced with respect to the one in the Starobinsky model, while maintaining a viable prediction on n {sub s}. We numerically reconstruct the full α-Attractors class of models testing the goodness of our high-energy approximation f ( R ) = R + aR {sup n} {sup −} {sup 1} + bR {sup 2}. Moreover, we also investigate the case of a single power law f ( R ) = γ R {sup 2} {sup −} {sup δ} theory, with γ and δ free parameters. We calculate analytically the predictions of this model on the scalar spectral index n {sub s} and the tensor-to-scalar ratio r and the values of δ which are allowed from the current observational results. We find that −0.015 < δ < 0.016, confirming once again the excellent agreement between the Starobinsky model and observation.

Efficacy of a Recombinant Turkey Herpesvirus H5 Vaccine Against Challenge With H5N1 Clades 1.1.2 and 2.3.2.1 Highly Pathogenic Avian Influenza Viruses in Domestic Ducks (Anas platyrhynchos domesticus).

Science.gov (United States)

Pantin-Jackwood, Mary J; Kapczynski, Darrell R; DeJesus, Eric; Costa-Hurtado, Mar; Dauphin, Gwenaelle; Tripodi, Astrid; Dunn, John R; Swayne, David E

2016-03-01

Domestic ducks are the second most abundant poultry species in many Asian countries and have played a critical role in the epizootiology of H5N1 highly pathogenic avian influenza (HPAI).In this study, the protective efficacy of a live recombinant vector vaccine based on a turkey herpesvirus (HVT) expressing the H5 gene from a clade 2.2 H5N1 HPAI strain (A/Swan/Hungary/4999/ 2006) (rHVT-H5/2.2), given at 3 days of age, was examined in Pekin ducks (Anas platyrhynchos domesticus). The vaccine was given alone or in combination with an inactivated H5N1 clade 2.3.2.1 reverse genetic (rgGD/2.3.2.1) vaccine given at 16 days of age, either as a single vaccination or in a prime-boost regime. At 30 days of age, ducks were challenged with one of two H5N1 HPAI viruses: A/duck/Vietnam/NCVD-2721/2013 (clade 1.1.2) or A/duck/Vietnam/NCVD-1584/2012 (clade 2.3.2.1.C). These viruses produced 100% mortality in less than 5 days in nonvaccinated control ducks. Ducks vaccinated with the rgGD/2.3.2.1 vaccine, with or without the rHVT-H5/2.2 vaccine, were 90%-100% protected against mortality after challenge with either of the two H5N1 HPAI viruses. The rHVT-H5/2.2 vaccine alone, however, conferred only 30% protection against mortality after challenge with either H5N1 HPAI virus; the surviving ducks from these groups shed higher amount of virus and for longer than the single-vaccinated rgGD/2.3.2.1 group. Despite low protection, ducks vaccinated with the rHVT-H5/2.2 vaccine and challenged with the clade 1.1.2 Vietnam virus had a longer mean death time than nonvaccinated controls (P = 0.02). A booster effect was found on reduction of virus shedding when using both vaccines, with lower oropharyngeal viral titers at 4 days after challenge with either HPAI virus (P study demonstrates the suboptimal protection with the rHVT-H5/2.2 vaccine given alone in Pekin ducks against H5N1 HPAI viruses and only a minor additive effect on virus shedding reduction when used with an inactivated vaccine in a

Förändrat omhändertagande av patienter med uretärsten : - Lärdomar från ett förbättringsarbete

OpenAIRE

Khatami, Annelie

2014-01-01

Bakgrund: Omkring 10-15 % av befolkningen, oftast i arbetsför ålder, riskerar att någon gång drabbas av njursten. Nationella riktlinjer för njurstensbehandling saknas, men studier stödjer behandling inom 48 timmar för snabb symtomlindring och minskade besvär för patienten. Inom studerad verksamhet var tiden från diagnos till behandling lång och återinläggningarna var många, varför ett förbättringsarbete initierades. Syfte: Syftet med förbättringsarbetet var att halvera tiden från diagnos till...

Türkiye-Fransa İlköğretim Eğitim Sistemlerinin ve İngilizce Ders Programlarının Karşılaştırılması A Comparison Of Primary Education Systems And English Instruction Program In Turkey And France

Directory of Open Access Journals (Sweden)

Senem Seda ŞAHENK ERKAN

2013-09-01

Full Text Available Compulsory education in Turkey is limited to grades 1st-12th grades of the primary and secondary levels, while it takes 10 years including grades 1st-5th of the primary school, grades 6th-9th of the secondary school, and the 1st grade of high school in France. English teaching starts in the 2nd grade (weekly hours: 2 hours in primary schools in Turkey, whereas English is taught for 5 years (1st -2nd:foreign language + art and history of art+ discovery of world proportionsvaried in schools (3th-5th: foreign language + science/technology +humanistic culture: 11 hours proportions varied in schools within theprimary school education in France. While primary education continues4 years in Turkey, it takes 5 years in France. In this regard, generalcharacteristics of the education systems and English instructionprograms in Turkey and primary schools system and Englishinstruction program in primary level in France are comparativelyanalyzed. The problem statement of this study can be expressed as‘what are the similarities and differences between education systemsand English instruction programs in Turkey and France?’ Litteraturemethod was used in this study. Finally this article will give commonsubjects of English instruction program in primary level in Turkey andFrance. Beside it will enumerate the different subjects of Englishinstruction program in primary level in Turkey and France. Türkiye’de zorunlu eğitim süresi ilkokul ve ortaöğretim kademelerini yani 1.-12. sınıfları kapsarken, Fransa’da ise bu süre 10 yıl olup, ilkokul (1-5. sınıf, ortaokul (6.-9. sınıf ve lise’nin 1. sınıfı dahildir. Türkiye’de ilköğretim kademesinde 2. sınıftan itibaren (haftalık ders saati: 2 İngilizce dersi okutulurken, Fransa’da ise ilkokul düzeyinde 5 yıl boyunca İngilizce dersi okutulmaktadır. Türkiye’de ilkokul kademesi 4 yıl iken, Fransa’da ilkokul basamağı 5 yıl sürmektedir. Türkiye’de ilkokul 2-4. sınıflarda ve

Den komplexa väven Att organisera för barns övergångar till och från förskoleklass

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Helena Ackesjö

2015-09-01

Full Text Available This study focuses on how children's transitions to and from preschool classes are organized in different schools. Principal’s arguments for this organization were sought via a web-based survey and analyzed using the frame factor theory in addition to theories of practical sense and the concept of continuity. The results show that children tend to make more transitions between social communities the younger they are. The distribution of the principal’s answers show that the majority of them, because of external conditions, split the preschool groups to new classes in the transition to preschool class. However, the same movements are not indicated in the transition to first grade. The results show how the work of organizing chidren’s transitions represent a complex web of external actual conditions as the number of children and the recruitment area of the school, the internal logics and ideas about what is best for children and best for continued learning as well as the school's own traditions of working with transitions. Föreliggande studie fokuserar på hur barns övergångar till och från förskoleklass organiseras på olika skolor. Via en webbaserad enkät söks skolledares argument för denna organisering. I analysen nyttjas ett ramfaktorteoretiskt tänkande som kompletteras med teorier om praktiskt förnuft samt kontinuitetsbegreppet. Resultaten visar att barn tenderar att göra fler övergångar mellan barngrupper och sociala gemenskaper ju yngre de är. Fördelningen av skolledarnas svar visar att majoriteten, på grund av yttre villkor, delar förskolegrupperna till nya klasser i övergången till förskoleklass. Däremot indikeras inte samma rörlighet i övergången till årskurs 1. Resultaten visar hur arbetet med att organisera övergångarna utgör en komplex väv av yttre faktiska villkor som barnantal och upptagningsområdets storlek, av inre logiker och föreställningar om vad som är det bästa för barnen och det b

re ipit tion re onstru tion using ringEwidth hronology of rim lyn ed r ...

Indian Academy of Sciences (India)

r nges from IHHEEIUS mF hue to he vy r inf ll it does not grow in the e stern rim l y eyond q rhw lF he ringEwidth hronology of rim l y n ed r @eh. IIUIEEIWVVAD prep red from tree ores olle ted from two disjun t m ture forests in western rim l y . @figure IAD h s een used in the present studyF het ils of the methodology ...

Systembolagets monopol kontra EU:s fria rörlighet för varor

OpenAIRE

Edqvist, Daniel; Gisslén, Kristofer

2006-01-01

Denna uppsats strävar efter att besvara frågorna: Har systembolaget rätt att som ensam aktör bedriva detaljhandel av alkohol i Sverige? Strider nuvarande reglering av svensk import och export av vin och sprit mot EG-rätten? EG-domstolen har i flera fall rörande offentliga monopol fastslagit att dessa i sig inte utgör något brott mot EG-rätten, under förutsättning att de anpassas till övrig EG-rätt på konkurrensrättens område. Det är därför med anledning av detta fullt möjligt för Systembolage...

Okul öncesi ve sınıf öğretmenliği öğrencilerinin öğrenme yaklaşımlarının incelenmesi / Analysis of approaches to learning of students in preschool and primary school teaching departments

Directory of Open Access Journals (Sweden)

Ceyhun OZAN

2012-12-01

Full Text Available ÖZETBu çalışmanın amacı, okul öncesi ve sınıf öğretmenliği öğrencilerinin öğrenme yaklaşımlarını tercih etme düzeylerini ve tercih düzeylerinin bölüm, cinsiyet ve sınıf düzeyi değişkenleri açısından anlamlı farklılık gösterip göstermediğini belirlemektir. Araştırma tarama modelinde bir çalışmadır. Araştırmanın evreni, 2011-2012 eğitim-öğretim yılı, bahar yarıyılında, Atatürk Üniversitesi, Kazım Karabekir Eğitim Fakültesi, Okul Öncesi Öğretmenliği ve Sınıf Öğretmenliği Programlarında öğrenim gören toplam 854 öğrenciden oluşmaktadır. Araştırmanın örneklemi ise evren içerisinden basit seçkisiz örnekleme yöntemiyle seçilen 330 kişiden oluşmaktadır. Verilerin elde edilmesinde Öğrenme Yaklaşımları ve Çalışma Becerileri Ölçeği kullanılmıştır. Araştırmanın sonuçlarına göre üç öğrenme yaklaşımı da yüz üzerinden altmış ortalamanın üstünde tercih edilmektedir. Okul öncesi ve sınıf öğretmenliği öğrencilerinin öğrenme yaklaşımları tercihleri arasında anlamlı farklılık yoktur. Cinsiyet değişkenine göre ise sadece yüzeysel öğrenme yaklaşımında anlamlı farklılık vardır. Yüzeysel öğrenme yaklaşımını erkek öğrenciler kız öğrencilere göre anlamlı ölçüde daha çok tercih etmişlerdir. Sınıf düzeyi değişkenine göre de sadece yüzeysel öğrenme yaklaşımında anlamlı farklılık vardır.

Automated synthesis of ["1"8F](2S,4R)-4-fluoroglutamine on a GE TRACERlab™ FX-N Pro module

International Nuclear Information System (INIS)

Zhang, Xiang; Basuli, Falguni; Shi, Zhen-Dan; Xu, Biying; Blackman, Burchelle; Choyke, Peter L.; Swenson, Rolf E.

2016-01-01

Glutamine (Gln) and its analogues may serve as imaging agents for tumor diagnosis using positron emission tomography (PET), especially for tumors with negative ["1"8F]FDG scan. We report the first automated synthesis of ["1"8F](2S,4R)-4-fluoroglutamine (["1"8F]FGln) on a GE TRACERlab™ FX-N Pro module. ["1"8F]FGln was obtained in 80±3 min with a radiochemical yield of 21±3% (n=5, uncorrected). The radiochemical purity was >98%, and optical purity 90±5%. The synthesis is highly reproducible with good chemical purity, radiochemical yield, and is suitable for translation to cGMP production. - Highlights: • The radiosynthesis of ["1"8F]fluoroglutamine was optimized with improved yield and purity. • Fully automated synthesis was established on a GE TRACERlab™ FX-N Pro module. • Radiochemical yield of 21±3% (uncorrected, n=5) was obtained with good reproducibility. • The automation could be easily adapted to cGMP production for routine clinical use.

Actividad citotóxica de aceites esenciales de Lippia origanoides H.B.K. y componentes mayoritarios Cytotoxic activity of essencial oils of Lippia origanoides H.B.K and its major constituents

Directory of Open Access Journals (Sweden)

Bibiana Zapata

2009-12-01

Full Text Available Introducción: Lippia origanoides H.B.K. (Verbenacea, es una planta aromática conocida comúnmente como "orégano". Los aceites esenciales de 8 muestras de L. origanoides y algunos de sus componentes mayoritarios fueron evaluados in vitro sobre la línea tumoral HeLa y la línea no tumoral Vero para identificar su potencial citotóxico. Materiales y métodos: la concentración inhibitoria cincuenta (IC50 se determinó mediante la técnica fotocolorimétrica del MTT (3-(4,5-Dimetiltiazol-2-il-2,5-bromuro difeniltetrazolio y los valores de IC50 se obtuvieron por análisis estadístico mediante regresión lineal simple. El índice de selectividad (IS, definido como la IC50 en células Vero sobre IC50 en células HeLa, fue calculado con el fin de encontrar aceites o componentes con potencial citotóxico selectivo hacia líneas celulares tumorales. Resultados y conclusiones: se determinó por cromatografía de gases y espectrometría de masas GC/MS la composición química de los aceites más citotóxicos. El aceite de L. origanoides que presentó la mayor actividad citotóxica sobre células HeLa con un valor de IC50 de 9,1 ± 1 μg/mL e índice de selectividad de 7,1, fue identificado como quimiotipo trans-β-cariofileno/ρ-cimeno. Los componentes mayoritarios del aceite quimiotipo trans-β-cariofileno/ρ-cimeno fueron: trans-β-cariofileno (11,3%, ρ-cimeno (11,2%, α-felandreno (9,9%, limoneno (7,2%, 1,8-cineol (6,5% y α-humuleno (6,0%. Los componentes mayoritarios evaluados no mostraron actividad citotóxica relevante sobre células HeLa, sólo el limoneno y β-mirceno presentaron valores de IS, respectivamente, de 6,97 y 3,01. Sin embargo, los valores de IC50 fueron más altos que el del aceite activo. Estos resultados sugieren que la actividad citotóxica de los aceites no se debe sólo a sus componentes mayoritarios, sino a un sinergismo entre sus componentes. Salud UIS 2009; 41: 215-222Introduction: Lippia origanoides H.B.K. (Verbenaceae

Küf Koleksiyonlarının Oluşturulması ve Korunumu

Directory of Open Access Journals (Sweden)

Şeminur Topal

2015-02-01

Full Text Available Çeşitli amaçlarla saf küf kültürlerinin uygun koşullarda ve özgün karakterlerini değiştirmeden korunmasını esas alan küf koleksiyonunun varlığı pek çok durum ve kuruluşun çalışmalarına destek sağlayabilir. Bu gerçekten hareketle NATO destekli ve 6 yıl süren Türkiye’de çeşitli tarımsal ürün ve gıdaların tarladan-tüketime kadarki küf floralarının taranmasına yönelik proje çalışmasında izole ve identifiye edilen küflerin bir koleksiyon bünyesinde değerlendirilmesi planlanmıştır. Pek çoğu, önemli dış koleksiyon merkezleri olan CBS-Hollanda ve CMI-İngiltere’deki uzmanların teyidini alan ve identifikasyonları tarafımızdan yapılan 10.000 civarındaki küf izolatından duplikasyon yaratabilecekleri elemine edilmiş, diğerleri korunuma alınmıştır. Yatık ve liyofilize kültürler olarak koleksiyonda bulunan küf suşlarının büyük bir kısmı için sistematik arşivleme çalışması tamamlanmış ve bilgisayar yardımı ile sınıflandırılmıştır. Bu sınıflama mevcut küflerin, izole edildiği örnek cinsi ve kayıt numaralarına, sağlandığı bölgelerin il trafik kod numaralarına, küf kültürlerinin cins ve tür isimlerine, liyofilize numaralarına ve koleksiyon odasındaki konumunun yer numaralarına göre olmak üzere 6 ayrı parametre için tek tek yapılarak arşivleme gerçekleştirilmiştir. Ayrıca identifiye edilen küflerin cins ve türlerine göre kartoteksleme işlemi yapılmıştır. Bu çalışmada koleksiyon ve korunumuna ilişkin ayrıntılı bilgiler verilmiştir.

The statistical properties of 111,112,113Sn studied with the Oslo method

Directory of Open Access Journals (Sweden)

Tveten G. M.

2015-01-01

Full Text Available The γ-ray strength function and level density of 111, 112, 113Sn are being studied at the Oslo Cyclotron Laboratory (OCL up to the neutron binding energy by applying the Oslo method to particle-γ coincidence data. The preliminary results for the γ-ray strength function are discussed in the context of the results for the more neutron-rich Sn-isotopes previously studied at OCL.

Excitation of isomeric states 1h11/2 in (γ, n) reactions

International Nuclear Information System (INIS)

Tonchev, A.P.; Gangrskij, Yu.P.; Belov, A.G.

1995-01-01

The cross sections of (γ, n) reactions were measured for ground and isomeric states 1h 11/2 in 16 isotopes of Pd, Cd, Sn, Te, Ba, Ce, Nd and Sm. The energy of γ-rays was placed in the region of Giant Dipole Resonance. An activation method of measurements has been used. IR dependence of neutron and proton number in nucleus was detected and of excitation energy of residual nucleus as well. Different factors influencing the values of the isomeric ratios are discussed. 20 refs., 5 figs., 2 tabs

Profil de la néphropathie diabétique à l’Hôpital Général de Référence Nationale de N'Djamena (Tchad)

Science.gov (United States)

Hamat, Ibrahim; Abderraman, Guillaume Mahamat; Cisse, Mouhamadou Moustapha; Youssouf, Mahamat; Djafar, Matar Saboune; Mbainguinam, Dionadji; Fotclossou, Tara

2016-01-01

Introduction Le diabète sucré constitue un véritable problème de santé et ses complications touchent plusieurs organes dont les reins. Un diagnostic précoce de la néphropathie diabétique permet de prendre en charge les patients plus efficacement et de façon multidisciplinaire, de retarder sa progression vers l'insuffisance rénale chronique. Peu d'études ont été faites en Afrique dans ce domaine. Au Tchad, nous ne disposons pas de données statistiques sur l'atteinte rénale liée au diabète. C'est pourquoi nous nous proposons d'étudier la néphropathie diabétique avec pour objectifs d'analyser le profil de la néphropathie diabétique des patients de l'hôpital général de référence nationale de N'Djamena. Méthodes Nous avions mené une étude transversale descriptive à l'Hôpital Générale de Référence Nationale de N'Djamena d'avril à septembre 2012. Etaient inclus dans l'étude tous les patients diabétiques hospitalisés ou suivis dans les services de néphrologie et d'endocrinologie. Résultats Il y avait 54 cas de néphropathie diabétique sur 181 patients soit 29,80%. L'âge de plus de 50 ans représentait 87%, le sexe masculin dominait avec 67%, la durée d'évolution du diabète au moment de la découverte de la néphropathie était de 10,25 ans, la pression artérielle moyenne était de 138 mm Hg, l'HbA1C était supérieur à 6,5% dans 74,5%, l'insuffisance rénale terminale était retrouvée dans 26,90%, une protéinurie à 2,65 g/24 h était détectée dans 60,30%. 57,4% des patients avaient une rétinopathie diabétique au stade III. Conclusion Au Tchad, la fréquence de la néphropathie diabétique est de l'ordre de 29,83%. C'est une affection qui touche les hommes avec une moyenne d'âge de 58,7 ans. Le diabète de type 2 est le plus fréquent avec 90,7% des cas. Les facteurs de risque mal contrôlés pouvaient conduire la néphropathie diabétique vers une altération de la fonction rénale notamment l'HTA (70,8%), un dés

Utveckling av bestrykning för papper avsedda för bläckstråleskrivare

OpenAIRE

Mattsson, Ylva

2002-01-01

Detta examensarbete har utförts på papperstillverkaren Arjo Wiggins’ forskningscenter i Beaconsfield,England. Företaget har planer på att börja tillverka en ny papperskvalitet för bläckstråleskrivare, varförsyftet med arbetet har varit att testa och utvärdera olika sammansättningar av kemikalier som lämparsig för bestrykning av bläckstrålepapper.Ett stort antal bestrykningar har testats med varierande resultat. Det svåraste har visat sig vara attnå en tillräckligt hög grad av vattenhållfasthe...

The removal of toxic metals from liquid effluents by ion exchange resins. Part IV: Chromium(III)/H+ /Lewatit SP112; La eliminación de metales tóxicos presentes en efluentes líquidos mediante resinas de cambio iónico. Parte IV: cromo(III)/H+/Lewatit SP112

Energy Technology Data Exchange (ETDEWEB)

Alguacil, F.J.

2017-09-01

This investigation presented results on the removal of chromium(III), from aqueous solution in the 0-5 pH range, using Lewatit SP112 cationic exchange resin. Several aspects affecting the ion exchange process were evaluated, including: the influence of the stirring speed, temperature, pH of the solution, resin dosage and aqueous ionic strength. The selectivity of the system was tested against the presence of other metals in the aqueous solution, whereas the removal of chromium(III) from solutions was compared with results obtained using multiwalled carbon nanotubes as adsorbents. From the batch experimental data, best fit of the results is obtained with the Langmuir model, whereas the ion exchange process is best explained by the pseudo-second order model, moreover, experimental data responded well to the film-diffusion controlled model. Elution of the chromium(III) loaded into the resin is well accomplished by the use of sodium hydroxide solutions. [Spanish] En este trabajo se presentan los resultados obtenidos en la eliminación de cromo(III) de disoluciones acuosas (pH 0-5) mediante la resina de intercambio catiónico Lewatit SP112. Se han investigado algunas variables que pueden afectar al sistema: influencia de la agitación, temperatura, pH y fuerza iónica del medio acuoso y cantidad de resina; también se ha investigado acerca de la selectividad del sistema cuando otros metales están presentes en el medio acuoso, comparándose los resultados de la eliminación del cromo(III) usando la resina con los resultados obtenidos cuando se emplea otro adsorbente como son los nanotubos de carbono de pared múltiple. Los resultados experimentales indican que la carga del cromo(III) en la resina responde mejor al modelo de Langmuir, mientras que los modelos cinéticos indican que la carga del metal en la resina responde al modelo de pseudo-segundo orden y difusión en la capa límite. La elución del cromo(III) se realiza con disoluciones de hidróxid.

Omvårdnadsåtgärder för att minska rädsla, oro och ångest hos barn 0-18 år i samband med en röntgenundersökning : En litteraturstudie

OpenAIRE

Mohsen, Nadja; Imsirovic, Amela

2016-01-01

Bakgrund: Att besöka en röntgenavdelning kan vara något nytt och skrämmande för många barn. Den nya miljön kan orsaka rädsla, oro och ångest hos barn. Därför är det viktigt att röntgensjuksköterskan har kunskap om barnets behov för att upplevelsen på röntgenavdelningen ska vara så bra som möjligt. Syfte: Syftet med den här studien är att beskriva omvårdnadsåtgärder för att minska rädsla, oro och ångest hos barn 0-18 år i samband med röntgenundersökning. Metod: Detta arbete är en litteraturstu...

Washout of tritium from 3R-3(3H)-L-aspartate in the aspartase reaction

International Nuclear Information System (INIS)

Katz, B.M.; Cook, P.F.

1987-01-01

Bacterial aspartase catalyzes the reversible conversion of L-aspartate to fumarate and ammonia. Recent studies that made use of deuterium and 15 N isotope effects suggested a carbanion intermediate mechanism in which C-N bond cleavage is rate determining. This could result in removal of a proton from the 3R position of aspartate at a rate of faster than the elimination of ammonia. 3R-3( 3 H)-Aspartate was prepared enzymatically using aspartase from fumarate, ammonia and 3 H 2 O and aspartate isolated via chromatography on Dowex 50W x 8 at pH 1, eluting with 2N pyridine. The rate of 3 H washout from this aspartate was then measured as a function of aspartate concentration and compared to the rate of production of fumarate. Tritium does washout of aspartate at a rate faster than fumarate is formed but the proton is apparently not rapidly equilibrated with solvent. The tritium washout experiments were supplemented using 3R-3( 2 H)-aspartate prepared as above with 2 H 2 O replacing 3 H 2 O and monitoring the appearance of 3R-3( 1 H)-aspartate via 1 H-NMR. Results confirm the tritium washout results. Data are discussed in terms of the carbanion mechanism

Att lära sig se trådraken – om tvekan och fokusförskjutning på väg mot förändrat kunnande

Directory of Open Access Journals (Sweden)

Marléne Johansson

2017-05-01

Full Text Available Utgångspunkten i denna artikel är empiriskt förankrade exempel från textilslöjdspraktiker i den svenska skolan; grundskolans slöjdundervisning årskurs 8 och ett specialutformat program inom gymnasieskolan med textil inriktning i årskurserna 1 och 3. Artikelns videoutdrag handlar alla om principiellt samma handling – trådrak mönsterutläggning på tyg – men, dels finns det två olika inramningar (grundskolan och gymnasieskolan, och dels exemplifierar de olika skeden av kunnande. Syftet är att beskriva skillnader i kunnande och vad som framstår som svårt för elever med liten eller ingen erfarenhet av att lägga ut mönster på ett tyg inför tillklippning och hur kunnandet förändras med ökande erfarenhet, liksom vilka nya svårigheter som följer med att elever arbetar med mönster av ökande komplexitet. Det som vid en första blick kan framstå som samma handling utvecklas över tid från något som framstår som enkel handling till att utvecklas i komplexitet. I de tvekan-situationer som beskriv finns potential för ett förändrat deltagande, där förändringen idealt är ett mer kompetent deltagande där ingen tvekan förekommer. Med ökad förtrogenhet kan uppmärksamheten förflyttas till något annat. Det vi är förtrogna med blir till rutiner och därmed behövs det en avvikelse för att fånga uppmärksamheten. I avvikelsen ligger möjligheterna till fortsatt lärande. Artikelns empiriska exempel synliggör dessa skillnader i kunnande som annars oreflekterat kan uppfattas som lika. Eleverna bygger in kunskap i sina handlingar, fokus flyttar från att inte veta vad man tittar på till självklarheten i handlingen. Eleverna lär sig se och urskilja.

Co-administration of recombinant major envelope proteins (rA27L and rH3L) of buffalopox virus provides enhanced immunogenicity and protective efficacy in animal models.

Science.gov (United States)

Kumar, Amit; Yogisharadhya, Revanaiah; Venkatesan, Gnanavel; Bhanuprakash, Veerakyathappa; Pandey, Awadh Bihari; Shivachandra, Sathish Bhadravati

2017-05-01

Buffalopox virus (BPXV) and other vaccinia-like viruses (VLVs) are causing an emerging/re-emerging zoonosis affecting buffaloes, cattle and humans in India and other countries. A27L and H3L are immuno-dominant major envelope proteins of intracellular mature virion (IMV) of orthopoxviruses (OPVs) and are highly conserved with an ability to elicit neutralizing antibodies. In the present study, two recombinant proteins namely; rA27L ( 21 S to E 110 ; ∼30 kDa) and rH3L( 1 M to I 280 ; ∼50 kDa) of BPXV-Vij/96 produced from Escherichia coli were used in vaccine formulation. A combined recombinant subunit vaccine comprising rA27L and rH3L antigens (10 μg of each) was used for active immunization of adult mice (20μg/dose/mice) with or without adjuvant (FCA/FIA) by intramuscular route. Immune responses revealed a gradual increase in antigen specific serum IgG as well as neutralizing antibody titers measured by using indirect-ELISA and serum neutralization test (SNT) respectively, which were higher as compared to that elicited by individual antigens. Suckling mice passively administered with combined anti-A27L and anti-H3L sera showed a complete (100%) pre-exposure protection upon challenge with virulent BPXV. Conclusively, this study highlights the potential utility of rA27L and rH3L proteins as safer candidate prophylactic antigens in combined recombinant subunit vaccine for buffalopox as well as passive protective efficacy of combined sera in employing better pre-exposure protection against virulent BPXV. Copyright © 2017 Elsevier B.V. All rights reserved.

KLASİK ÇÖZÜCÜLERE BİR ALTERNATİF; İYONİK SIVILAR

OpenAIRE

KOLANCILAR, Hakan

2010-01-01

Organik reaksiyonlar genelde çözücü ortamında yapılır. Son yıllarda yeni bir çözücü sınıfı bulundu ve bunlar iyonik sıvı olarak adlandırılır. Bu çözücüler çoğunlukla oda sıcaklığında sıvıdırlar ve iyonik türlerden oluşurlar. Düşük buhar basınçları, mükemmel kimyasal ve termal kararlılıkları, potansiyel geri kazanımları ve tekrar kullanımları gibi dikkat çekici özelliklere sahiptirler. İyonik sıvılar geniş olarak araştırılmaktadır ve organik sentez, enzimatik kataliz, ayırma işlemleri vb. gibi...

Kıl Keçi ve Saanen x Kıl Keçi Melezlerinin (F1, G1, Üretici Şartlarında Döl Verim Özellikleri Bakımından Karşılaştırılması

Directory of Open Access Journals (Sweden)

Hilal Tozlu Çelik

2014-11-01

Full Text Available Bu araştırma, Amasya ili Sarılar köyünde (40°54'23"N, 35°08'dk5"E özel bir işletmede 2011-2012 yılları arasında yetiştirilen Saanen x Kıl keçi melezleri (F1, G1 ve Kıl keçilerinde döl verimi özelliklerini tespit etmek ve bu özellikler üzerine genotip ve yıl faktörlerinin etkisini ortaya koymak amacıyla yapılmıştır. Araştırmada döl verim özelliklerinden 2011 yılı için sadece ikiz doğuran keçi oranı bakımından genotipler arasında istatistiki farklılık belirlenmiştir. İkiz doğuran keçi oranı Kıl keçilerle, F1 melezlerinde benzer bulunmuş ve G1 melezlerinde ise her iki genotipten farklı bulunmuştur. 2012 yılında genotipler arasında kısır kalan keçi, ikiz doğuran keçi ve ölü doğum yapan keçi oranı bakımından istatistiki farklılıklar olduğu tespit edilmiştir. Kısırlık oranının, Saanen x Kıl keçi F1, G1 melezlerinde Kıl keçilerinden daha yüksek olduğu belirlenmiştir. İkiz doğuran keçi oranı F1 genotipinde yüksek, G1 genotipinde ve Kıl keçilerinde benzer bulunmuştur.

Når medarbejdere håndterer hinandens følelser

DEFF Research Database (Denmark)

Poder, Poul

2010-01-01

  Når medarbejdere søger at skabe eksempelvis en lærende eller udviklingsorienteret arbejdspladskultur, forudsætter sådanne mål, at den enkelte tør lade sig udfordre, og derved bliver identitetsarbejdet et emotionelt involverende anliggende mellem kolleger. Ved at tematisere forudsætninger for og...

Kıl Keçi ve Saanen x Kıl Keçi Melezlerinin (F1, G1, Çiftçi Şartlarında Süt Verim Özellikleri Bakımından Karşılaştırılması

Directory of Open Access Journals (Sweden)

Hilal Tozlu Çelik

2014-11-01

Full Text Available Bu araştırma, Amasya ili Sarılar köyü, özel bir işletmede 2011-2012 yılları arasında yetiştirilen Saanen x Kıl keçi melezleri (F1, G1 ve Kıl keçilerinde süt verimi özellikleri üzerine genotip, yıl ve yaş faktörlerinin etkisini ortaya koymak amacıyla yapılmıştır. Araştırmada 2011 ve 2012 yıllarında günlük ortalama süt verimi (GOSV, laktasyon süresi (LS ve laktasyon süt verimi (LSV üzerine genotipin etkili olduğu bulunmuştur. 2011 yılında yaşın tüm genotiplerde GOSV ve LSV etkisinin olduğu tespit edilmiştir. Araştırmada 2012 yılında yaşın tüm genotiplerde GOSV ve LS'ne etkisinin olduğu saptanmıştır. F1 genotipinde ve Kıl keçilerde yılın GOSV, LSV ve LS üzerine etkili olduğu bulunmuştur. G1 genotipinde yılın sadece LS üzerine etkisi olduğu saptanmıştır. Sonuç olarak çiftçi şartlarında yetiştirilen Saanen x Kıl keçi F1 ve G1 genotipinin süt verim özelliklerinin Kıl keçilerden daha yüksek olduğu söylenebilir.

Choriocarcinome gestationnel révélé par une métastase rénale

African Journals Online (AJOL)

B. Sadiki

d'une néphrectomie d'hémostase en cas d'hématurie persistante. La néphrectomie peut être remplacée par une embolisation sélective. [10]. Conclusion. Les métastases rénales du CG sont rares. Cette éventualité doit être évoquée par l'urologue en présence d'un syndrome tumoral rénal chez les patientes en âge de ...

Att ligga som föräldrarna bäddar : En kvantitativ studie om ungdomars sexuella handlingsutrymme

OpenAIRE

Hellberg, My; Sarin, Sandra

2014-01-01

Sammanfattning Denna studie avser att undersöka ungdomars sexuella handlingsutrymme. Syftet är att studera om det sexuella handlingsutrymmet uppfattas olika när det gäller ungdomar med, respektive utan, en lindrig intellektuell funktionsnedsättning. I analysen har särskild hänsyn tagits till tre bakgrundsfaktorer; ungdomars kön, föräldrars födelseland samt föräldrars religiositet. Definitionen av det sexuella handlingsutrymmet bygger på den unges uppfattning om vårdnadshavarens restriktioner ...

PB2 mutations D701N and S714R promote adaptation of an influenza H5N1 virus to a mammalian host.

Science.gov (United States)

Czudai-Matwich, Volker; Otte, Anna; Matrosovich, Mikhail; Gabriel, Gülsah; Klenk, Hans-Dieter

2014-08-01

Mutation D701N in the PB2 protein is known to play a prominent role in the adaptation of avian influenza A viruses to mammalian hosts. In contrast, little is known about the nearby mutations S714I and S714R, which have been observed in some avian influenza viruses highly pathogenic for mammals. We have generated recombinant H5N1 viruses with PB2 displaying the avian signature 701D or the mammalian signature 701N and serine, isoleucine, and arginine at position 714 and compared them for polymerase activity and virus growth in avian and mammalian cells, as well as for pathogenicity in mice. Mutation D701N led to an increase in polymerase activity and replication efficiency in mammalian cells and in mouse pathogenicity, and this increase was significantly enhanced when mutation D701N was combined with mutation S714R. Stimulation by mutation S714I was less distinct. These observations indicate that PB2 mutation S714R, in combination with the mammalian signature at position 701, has the potential to promote the adaptation of an H5N1 virus to a mammalian host. Influenza A/H5N1 viruses are avian pathogens that have pandemic potential, since they are spread over large parts of Asia, Africa, and Europe and are occasionally transmitted to humans. It is therefore of high scientific interest to understand the mechanisms that determine the host specificity and pathogenicity of these viruses. It is well known that the PB2 subunit of the viral polymerase is an important host range determinant and that PB2 mutation D701N plays an important role in virus adaptation to mammalian cells. In the present study, we show that mutation S714R is also involved in adaptation and that it cooperates with D701N in exposing a nuclear localization signal that mediates importin-α binding and entry of PB2 into the nucleus, where virus replication and transcription take place. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

Experimental study on the impedance of linear discharge R.F. ion sources - modifications on the 'MOAK' type source; Etude experimentale de l'impedance des sources d'ions H. F. a decharge lineaire - modifications au modele de source du types 'MOAK'

Energy Technology Data Exchange (ETDEWEB)

Fremiot, Ch [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1962-07-15

A method of measuring the ion R.F. source impedance is described, and the influence of the working parameters on that impedance is studied. The origin of some working anomalies is deduced with a new coupling method. The gas flow is decreased by modifying the geometry of the discharge vessel. (author) [French] On decrit une methode de mesure de l'impedance d'une source d'ions H.F. et on etudie l'influence des parametres de fonctionnement sur cette Impedance. On en deduit l'origine de quelques anomalies de fonctionnement ainsi qu'une nouvelle methode de couplage. On reduit le debit gazeux en modifiant la geometrie de l'ampoule. (auteur)

A pilot study of a novel therapeutic approach to obesity: CNS modification by N.I.R. H.E.G. neurofeedback.

Science.gov (United States)

Percik, Ruth; Cina, Jenny; Even, Batel; Gitler, Asaf; Geva, Diklah; Seluk, Lior; Livny, Abigail

2018-02-07

Despite the thorough mapping of brain pathways involved in eating behavior, no treatment aimed at modulating eating dysregulation from its neurocognitive root has been established yet. We aimed to evaluate the effect of N.I.R. H.E.G. (Near Infra-Red Hemoencephalography) neurofeedback training on appetite control, weight and food-related brain activity. Six healthy male participants with overweight or mild obesity went through 10 N.I.R. H.E.G. neurofeedback sessions designed to practice voluntary activation of the prefrontal cortex. Weight, eating behavior, appetite control and brain activity related to food and self-inhibition based on fMRI were evaluated before and after neurofeedback training. Our study group demonstrated a positive trend of increased self-control and inhibition related to food behavior, reduced weight and increased activation during an fMRI response-inhibition task (Go-No-Go - GNG) in the predefined region of interest (ROI): superior orbitofrontal cortex (sOFC). N.I.R. H.E.G. holds a promising potential as a feasible neurofeedback platform for modulation of cortical brain circuits involved in self-control and eating behavior and should be further evaluated and developed as a brain modifying device for the treatment and prevention of obesity. Copyright © 2018. Published by Elsevier Ltd.

Human right, disability and family life Mannréttindi, fötlun og fjölskyldulíf. Í tilefni yfirfærslu málefna fatlaðs fólks til sveitarfélaga

Directory of Open Access Journals (Sweden)

Hanna Björg Sigurjónsdóttir

2009-12-01

Full Text Available Abstract in English is unavailable.Samningur Sameinuðu þjóðanna um réttindi fatlaðs fólks var undirritaður af Íslandi í mars 2007, en með undirrituninni skuldbinda íslensk stjórnvöld sig til að gera ekkert sem gengur gegn efni samningsins. Um allan heim er nú litið til þessa samnings sem leiðarljóss í málefnum fatlaðs fólks og þjóðir heims, Ísland þar með talið, eru nú óðum að staðfesta samninginn og aðlaga lagaumhverfi sitt að honum. Eitt af lykilatriðunum við yfirfærslu málefna fatlaðra til sveitarfélaganna er kynning á þessum nýja samningi og mannréttindaáherslum sem þar er að finna, en þekking á innihaldi samningsins er nauðsynleg forsenda þess að jafnrétti og mannréttindi fatlaðs fólks hér á landi verði tryggð. Þessi grein fjallar um einn hóp fatlaðs fólks, foreldra með þroskahömlun, og rétt þeirra til fjölskyldulífs sem dæmi um breyttan skilning á stöðu fatlaðs fólks í samfélaginu og þá þjónustu sem það á rétt á. Rakið er hvernig réttur foreldra til samvista við börn sín hefur þróast á undanförnum áratugum í mannréttindasáttmálum og dómsúrskurðum. Niðurstöður sýna að ef foreldrar með þroskahömlun eiga að njóta þeirrar réttarverndar sem samræmist markmiðum stjórnarskrár íslenska lýðveldisins, mannréttindasáttmála Evrópu um friðhelgi fjölskyldulífs og samnings Sameinuðu þjóðanna um réttindi fatlaðs fólks er ljóst að þörf er á verulegu átaki og viðhorfsbreytingum innan stofnana ríkis og sveitarfélaga, sem hafa með höndum málefni fatlaðs fólks, barnaverndar og félagslegs stuðnings, svo og dómskerfisins alls, til að tryggja að foreldrar með þroskahömlun standi jafnfætis öðrum foreldrum.

Choc hémorragique suite à une ponction biopsie rénale (PBR): à ...

African Journals Online (AJOL)

Nous rapportons l'observation d'un patient âgé de 27 ans ayant bénéficié d'une PBR pour un diagnostic étiologique d'une insuffisance rénale aigue, l'évolution après la biopsie a été marquée par l'installation d'un choc hémorragique d'où la prise en charge en réanimation avec une néphrectomie d'hémostase. Pan African ...

f(R)-theories of gravity and gravitational baryogenesis

Energy Technology Data Exchange (ETDEWEB)

Lambiase, G; Scarpetta, G [Dipartimento di Fisica ' E.R. Caianiello' Universita di Salerno, 84081 Baronissi (Italy); INFN - Gruppo Collegato di Salerno (Italy)

2007-05-15

The mechanism for generating the baryon asymmetry in the Universe is discussed in the framework of f(R)-theories of gravity. The gravitational baryogenesis, based on the coupling between the Ricci scalar curvature R and the baryon current, allows to determine the form of gravity Lagrangian, i.e. L(R) {approx} R{sup n}. The current bound on the observed matter-antimatter asymmetry and Big Bang Nucleosynthesis data lead to n = 0.97.

Hepatitis B virus X protein mutant HBxΔ127 promotes proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT

Energy Technology Data Exchange (ETDEWEB)

Liu, Fabao [Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071 (China); Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071 (China); You, Xiaona [Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071 (China); Chi, Xiumei [Department of Hepatology, The First Hospital, Jilin University, Changchun 130021 (China); Wang, Tao [Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071 (China); Ye, Lihong [Department of Biochemistry, College of Life Sciences, Nankai University, Tianjin 300071 (China); Niu, Junqi, E-mail: junqiniu@yahoo.com.cn [Department of Hepatology, The First Hospital, Jilin University, Changchun 130021 (China); Zhang, Xiaodong, E-mail: zhangxd@nankai.edu.cn [Department of Cancer Research, College of Life Sciences, Nankai University, Tianjin 300071 (China)

2014-02-07

Highlights: • Relative to wild type HBx, HBX mutant HBxΔ127 strongly enhances cell proliferation. • Relative to wild type HBx, HBxΔ127 remarkably up-regulates miR-215 in hepatoma cells. • HBxΔ127-elevated miR-215 promotes cell proliferation via targeting PTPRT mRNA. - Abstract: The mutant of virus is a frequent event. Hepatitis B virus X protein (HBx) plays a vital role in the development of hepatocellular carcinoma (HCC). Therefore, the identification of potent mutant of HBx in hepatocarcinogenesis is significant. Previously, we identified a natural mutant of the HBx gene (termed HBxΔ127). Relative to wild type HBx, HBxΔ127 strongly enhanced cell proliferation and migration in HCC. In this study, we aim to explore the mechanism of HBxΔ127 in promotion of proliferation of hepatoma cells. Our data showed that both wild type HBx and HBxΔ127 could increase the expression of miR-215 in hepatoma HepG2 and H7402 cells. However, HBxΔ127 was able to significantly increase miR-215 expression relative to wild type HBx in the cells. We identified that protein tyrosine phosphatase, receptor type T (PTPRT) was one of the target genes of miR-215 through targeting 3′UTR of PTPRT mRNA. In function, miR-215 was able to promote the proliferation of hepatoma cells. Meanwhile anti-miR-215 could partially abolish the enhancement of cell proliferation mediated by HBxΔ127 in vitro. Knockdown of PTPRT by siRNA could distinctly suppress the decrease of cell proliferation mediated by anti-miR-215 in HepG2-XΔ127/H7402-XΔ127 cells. Moreover, we found that anti-miR-215 remarkably inhibited the tumor growth of hepatoma cells in nude mice. Collectively, relative to wild type HBx, HBxΔ127 strongly enhances proliferation of hepatoma cells through up-regulating miR-215 targeting PTPRT. Our finding provides new insights into the mechanism of HBx mutant HBxΔ127 in promotion of proliferation of hepatoma cells.

Cosmic strings in f(R,L{sub m}) gravity

Energy Technology Data Exchange (ETDEWEB)

Harko, Tiberiu [University College London, Department of Mathematics, London (United Kingdom); Lake, Matthew J. [Naresuan University, The Institute for Fundamental Study, ' ' The Tah Poe Academia Institute' ' , Phitsanulok (Thailand); Ministry of Education, Thailand Center of Excellence in Physics, Bangkok (Thailand)

2015-02-01

We consider Kasner-type static, cylindrically symmetric interior string solutions in the f(R,L{sub m}) theory of modified gravity. The physical properties of the string are described by an anisotropic energy-momentum tensor satisfying the condition T{sub t}{sup t} = T{sub z}{sup z}; that is, the energy density of the string along the z-axis is equal to minus the string tension. As a first step in our study we obtain the gravitational field equations in the f(R,L{sub m}) theory for a general static, cylindrically symmetric metric, and then for a Kasner-type metric, in which the metric tensor components have a power law dependence on the radial coordinate r. String solutions in two particular modified gravity models are investigated in detail. The first is the so-called ''exponential'' modified gravity, in which the gravitational action is proportional to the exponential of the sum of the Ricci scalar and matter Lagrangian, and the second is the ''self-consistent model'', obtained by explicitly determining the gravitational action from the field equations under the assumption of a power law dependent matter Lagrangian. In each case, the thermodynamic parameters of the string, as well as the precise form of the matter Lagrangian, are explicitly obtained. (orig.)

Co-occurrence and distribution of East (L1014S) and West (L1014F) African knock-down resistance in Anopheles gambiae sensu lato population of Tanzania

Science.gov (United States)

Kabula, Bilali; Kisinza, William; Tungu, Patrick; Ndege, Chacha; Batengana, Benard; Kollo, Douglas; Malima, Robert; Kafuko, Jessica; Mohamed, Mahdi; Magesa, Stephen

2014-01-01

Objective Insecticide resistance molecular markers can provide sensitive indicators of resistance development in Anopheles vector populations. Assaying these makers is of paramount importance in the resistance monitoring programme. We investigated the presence and distribution of knock-down resistance (kdr) mutations in Anopheles gambiae s.l. in Tanzania. Methods Indoor-resting Anopheles mosquitoes were collected from 10 sites and tested for insecticide resistance using the standard WHO protocol. Polymerase chain reaction-based molecular diagnostics were used to genotype mosquitoes and detect kdr mutations. Results The An. gambiae tested were resistance to lambdacyhalothrin in Muheza, Arumeru and Muleba. Out of 350 An. gambiae s.l. genotyped, 35% were An. gambiae s.s. and 65% An. arabiensis. L1014S and L1014F mutations were detected in both An. gambiae s.s. and An. arabiensis. L1014S point mutation was found at the allelic frequency of 4–33%, while L1014F was at the allelic frequency 6–41%. The L1014S mutation was much associated with An. gambiae s.s. (χ2 = 23.41; P protocolo estándar de la OMS. Mediante un diagnóstico molecular basado en la PCR se genotiparon los mosquitos y se detectaron los genotipos kdr. Resultados Los An. gambiae evaluados eran resistentes a lambdacialotrina en Muheza, Arumeru y Muleba. De 350 An. gambiae s.l. genotipados, 35% eran An. gambiae s.s. y 65% eran An. arabiensis. Se detectaron mutaciones L1014S y L1014F tanto en An. gambiae s.s. como en An. arabiensis. La mutación puntual L1014S se encontró con una frecuencia alélica de 4-33%, mientras que L1014F tenía una frecuencia alélica de 6-14%. La mutación L1014S estaba ampliamente asociada a An. gambiae s.s. (Chi-Cuadrado = 23.41; P < 0.0001) y la L1014F estaba asociada con An. arabiensis (Chi-Square = 11.21; P = 0.0008). El alelo L1014S estaba significativamente asociado con mosquitos resistentes a la lambdacialotrina (P < 0.001). Conclusión La

Identification and analytical characterization of six synthetic cannabinoids NNL-3, 5F-NPB-22-7N, 5F-AKB-48-7N, 5F-EDMB-PINACA, EMB-FUBINACA, and EG-018.

Science.gov (United States)

Liu, Cuimei; Jia, Wei; Hua, Zhendong; Qian, Zhenhua

2017-08-01

Clinical and forensic toxicology laboratories are continuously confronted by analytical challenges when dealing with the new psychoactive substances phenomenon. The number of synthetic cannabinoids, the chemical diversity, and the speed of emergence make this group of compounds particularly challenging in terms of detection, monitoring, and responding. Three indazole 7N positional isomer synthetic cannabinoids, two ethyl 2-amino-3-methylbutanoate-type synthetic cannabinoids, and one 9H-carbazole substituted synthetic cannabinoid were identified in seized materials. These six synthetic cannabinoid derivatives included: 1H-benzo[d] [1,2,3]triazol-1-yl 1-(5-fluoropentyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (NNL-3, 1), quinolin-8-yl 1-(5-fluoropentyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (5F-NPB-22-7N, 2), N-((1 s,3 s)-adamantan-1-yl)-1-(5-fluoropentyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide (5F-AKB-48-7N, 3), ethyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate (5F-EDMB-PINACA, 4), ethyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoate (EMB-FUBINACA, 5), and naphthalen-1-yl(9-pentyl-9H-carbazol-3-yl)methanone (EG-018, 6). The identification was based on ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry (UHPLC-QTOF-MS), gas chromatography-mass spectrometry (GC-MS), and nuclear magnetic resonance spectroscopy (NMR). The analytical characterization of these six synthetic cannabinoids was described, so as to assist forensic laboratories in identifying these compounds or other substances with similar structure in their case work. To our knowledge, no analytical data about the compounds 1-5 have appeared until now, making this the first report on these compounds. The GC-MS data of 6 has been reported, but this study added the LC-MS, NMR, and Fourier transform infrared (FTIR), data to render the analytical data collection process more complete. Copyright © 2017 John Wiley & Sons, Ltd

Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence

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Ping Jihui

2011-01-01

Full Text Available Abstract Background To understand the evolutionary steps required for a virus to become virulent in a new host, a human influenza A virus (IAV, A/Hong Kong/1/68(H3N2 (HK-wt, was adapted to increased virulence in the mouse. Among eleven mutations selected in the NS1 gene, two mutations F103L and M106I had been previously detected in the highly virulent human H5N1 isolate, A/HK/156/97, suggesting a role for these mutations in virulence in mice and humans. Results To determine the selective advantage of these mutations, reverse genetics was used to rescue viruses containing each of the NS1 mouse adapted mutations into viruses possessing the HK-wt NS1 gene on the A/PR/8/34 genetic backbone. Both F103L and M106I NS1 mutations significantly enhanced growth in vitro (mouse and canine cells and in vivo (BALB/c mouse lungs as well as enhanced virulence in the mouse. Only the M106I NS1 mutation enhanced growth in human cells. Furthermore, these NS1 mutations enhanced early viral protein synthesis in MDCK cells and showed an increased ability to replicate in mouse interferon β (IFN-β pre-treated mouse cells relative to rPR8-HK-NS-wt NS1. The double mutant, rPR8-HK-NS-F103L + M106I, demonstrated growth attenuation late in infection due to increased IFN-β induction in mouse cells. We then generated a rPR8 virus possessing the A/HK/156/97 NS gene that possesses 103L + 106I, and then rescued the L103F + I106M mutant. The 103L + 106I mutations increased virulence by >10 fold in BALB/c mice. We also inserted the avian A/Ck/Beijing/1/95 NS1 gene (the source lineage of the A/HK/156/97 NS1 gene that possesses 103L + 106I, onto the A/WSN/33 backbone and then generated the L103F + I106M mutant. None of the H5N1 and H9N2 NS containing viruses resulted in increased IFN-β induction. The rWSN-A/Ck/Beijing/1/95-NS1 gene possessing 103L and 106I demonstrated 100 fold enhanced growth and >10 fold enhanced virulence that was associated with increased tropism for lung

Miljø- og arbejdsmiljøvenlig bygningsisolering af fåreuld og hør

DEFF Research Database (Denmark)

Hansen, Ernst Jan de Place

2001-01-01

Resume af rapport om miljø- og arbejdsmiljøvenlig bygningsisolering af fåreuld og hør og mulighederne for at starte en dansk produktion, udarbejdet af Esbensen Rådgivende Ingeniører, Sonnerup ECO Advise og HBC A/S under Energistyrelsens udviklingsprogram "Miljø- og arbejdsmiljøvenlig isolering"...

Samstämmighet i lärares bedömning av nationella prov i läsförståelse

Directory of Open Access Journals (Sweden)

Michael Tengberg

2016-04-01

Full Text Available Tillförlitlighet i bedömning är en avgörande komponent i varje testprogram där testtagares resultat bygger på bedömares tolkningar utifrån en bedömningsskala eller en bedömningsguide. Utförliga svar på öppna uppgifter bedöms exempelvis sällan som antingen ”rätt” eller ”fel”. Istället tillämpas skalan eller bedömningsguiden för att fastställa i vilken utsträckning svaret uppvisar den efterfrågade kompetensen. I den här artikeln redovisas resultat från en studie av bedömarreliabilitet på öppna uppgifter i det nationella provets svenska läsförståelsedel i årskurs nio.För att undersöka i vilken mån provsystemet skapar förutsättningar för god bedömarreliabilitet har sex lärare fått bedöma tre elevers lösningar av 14 öppna uppgifter, totalt 252 bedömningar. Analyserna innefattar konsensusestimat (procentuell samstämmighet och Cohens kappa och konsistensestimat (ICC. Dessutom har kvalitativa analyser genomförts på uppgiftsnivå för att visa på aspekter i uppgiftskonstruktionen som kan ligga till grund för låg bedömarreliabilitet.Resultaten från studien visar på moderata nivåer av bedömarreliabilitet, både ifråga om kappavärden (.73 och ICC (.82, vilket motsvarar en variation mellan bedömningarna som får stora konsekvenser för elevernas slutgiltiga provresultat. I artikeln diskuterar vi resultatens implikationer för rättvis bedömning av elevers läsförmåga i Sverige. Vi för också ett resonemang om olika sätt att stärka bedömarreliabiliteten det nationella provet i läsförståelse.

Generator 113Sn- 113mIn. Study of the most important characteristics in the evaluate composition for the preparation of clinical labelled compounds

International Nuclear Information System (INIS)

Adan, L.; Rebollo, D. V.

1978-01-01

The design for the construction of a generator 113 S n -113m l n is described. A systematic assay for de adequate adsorbents has been made, to obtain solutions of high radiochemical purity, as it is required for the radiopharmaceutical preparations. The control of purity is carried on by qualitative and quantitative analysis of the solutions, complemented by radiochemical techniques. The following physico-chemical parameters has been determinate; consecutive equilibrium constants, pH, distribution constants, separation factors and electrophoretic factors. It has been considered the measure of these parameters for the best quality In the preparation of the radiopharmaceutical compounds. (Author) 53 refs

Det diskursiva skrivandets funktion – en läromedelsanalys

Directory of Open Access Journals (Sweden)

Jenny Magnusson

2018-03-01

Full Text Available Flera forskare har visat att lärare i skolan inte undervisar tillräckligt mycket och tillräckligt tidigt i diskursivt skrivande, ett skrivande som elever behöver för att klara sig i samhället. Som en följd av detta har det diskursiva skrivandet under de senaste åren blivit allt mer uppmärksammat i nya styrdokument och i nya läromedel. Utgångspunkten i den här artikeln är att undersöka vilket stöd lärare får för att klara den uppmärksamheten, alltså de nya kraven som styrdokumenten ställer när det gäller diskursivt skrivande.Det diskursiva skrivandets funktion undersöks här i skrivuppgifter i 19 läromedel i svenska för lågstadiet, där utgångspunkten är den stora betydelse som funktionen har när det gäller skolskrivande, i form av ett tydligt syfte, kontext och mottagare. Ivaničs skrivdiskurser är det analysverktyg som används, och skrivuppgifterna har kategoriserats utifrån dessa diskurser.Det analysen visar är framförallt att variationen är liten i skrivuppgifterna. Eleverna får träna genreform och process, men inte mycket som har med funktion i en samhällskontext utanför skolan att göra. Därutöver visar resultaten att tydliga kontexter och tydliga mottagare är ovanligt i skrivuppgifterna, och i relation till tidigare forskning kan detta ses som problematiskt, då dessa aspekter har visat sig vara avgörande för ett framgångsrikt skrivande.

A single one-step radiosynthesis of [{sup 18}F]L.B.T.-999, a novel and selective dat radioligand for PET

Energy Technology Data Exchange (ETDEWEB)

Dolle, F.; Hinnen, F.; Saba, W.; Schollhorn-peyronneau, M.A.; Valette, H.; Bottlaender, M. [Service Hospitalier Frederic Joliot, DSV/ Institut d' Imagerie BioMedicale, 91 - Orsay (France); Helfenbein, J.; Le gailliard, J. [Institut National de la Sante et de la Recherche Medicale (INSERM), U484, Orphachem, ZATE, 63 - Clermont Ferrand (France); Mavel, S.; Mincheva, Z.; Garreau, L.; Chalon, S.; Guilloteau, D.; Emond, P. [Institut National de la Sante et de la Recherche Medicale (INSERM), U619, 37 - Tours (France); Mavel, S.; Garreau, L.; Chalon, S.; Guilloteau, D.; Emond, P. [Universite Francois Rabelais de Tours, 37 (France); Halldin, C. [Karolinska Institut, Dept. of Clinical Neuroscience, Karolinska Hospital, Stockholm (Sweden); Madelmont, J.C. [Institut National de la Sante et de la Recherche Medicale (INSERM) U484, Lab. Etude Metabolique des Molecules Marquees, 63 - Clermont Ferrand (France); Deloye, J.B. [Biopole Clermont Limagne, Lab. Cyclopharma, 63 - Saint Beauzire (France); Guilloteau, D. [Centre Hospitalier Regional Universitaire, 37 - Tours (France)

2008-02-15

L.B.T.-999 (8-((E)-4-fluoro-but-2-enyl)-3-beta-p-tolyl-8- aza-bi-cyclo[3.2.1]octane-2-beta-carboxylic acid methyl ester) is a recently developed cocaine derivative belonging to a new generation of highly selective D.A.T. ligands [1-3]. Initial fluorine-18-labelling of L.B.T.-999 was based on the robust and reliable two-step radiochemical pathway often reported for such tropane derivatives, involving first the preparation of (E)-1-[{sup 18}F]fluoro-4-tosyloxybut-2-ene followed by a N-alkylation reaction with the appropriate nor-tropane moiety [4]. In the present work, a simple one-step fluorine-18-labelling of L.B.T.-999 is reported, based on a chlorine-for-fluorine nucleophilic aliphatic substitution, facilitating as expected both automation and final H.P.L.C. purification. The process involves: (A) reaction of K[{sup 18}F]F-Kryptofix 222 with the chlorinated precursor (3.5-4.5 mg) at 165 degrees C for 10 min in D.M.S.O. (0.6 m L) followed by (B) C-18 PrepSep cartridge pre-purification and finally (C) semi preparative HPLC purification on a Waters Symmetry C-18. Typically, 3.70-5.92 GBq of [{sup 18}F]L.B.T.-999 (> 95% chemically and radiochemically pure) could be obtained with specific radioactivities ranging from 37 to 111 GBq/micro-mol within 85-90 min (HPLC purification and Sep-Pak-based formulation included), starting from a 37.0 GBq [{sup 18}F]fluoride batch (overall radiochemical yields: 10-16%, non decay corrected) [5].Supported in part by the E.C. - F.P.6-project D.i.M.I. (L.S.H.B.-C.T.- 2005-512146) and the R.N.T.S. 03 B 243 Fluoropak program. (authors)

Chemie für den Maschinenbau. Bd. 2: Organische Chemie für Kraft- und Schmierstoffe, Polymerchemie für Polymerwerkstoffe

OpenAIRE

Gerthsen, Tarsilla

2008-01-01

Dieses Buch beinhaltet zunächst eine kurze Einführung in die Organische Chemie. Organische Grundkenntnisse sind die Voraussetzung, um nicht nur Kraftstoffe und Schmierstoffe zu verstehen, sondern im Besonderen die Polymerchemie für Polymerwerkstoffe. Die Vorlesung "Polymerwerkstoffe" wird im Maschinenbaustudium in einem höheren Semester angeboten. Allgemeine chemische Grundkenntnisse für Chemie im Nebenfach findet man im Buch 1 "Chemie für Maschinenbau - Anorganische Chemie f...

Stability and Unimolecular Reactivity of Palladate(II) Complexes [Ln PdR3 ]- (L=Phosphine, R=Organyl, n=0 and 1).

Science.gov (United States)

Kolter, Marlene; Koszinowski, Konrad

2016-10-24

The reduction of Pd II precatalysts to catalytically active Pd 0 species is a key step in many palladium-mediated cross-coupling reactions. Besides phosphines, the stoichiometrically used organometallic reagents can afford this reduction, but do so in a poorly understood way. To elucidate the mechanism of this reaction, we have treated solutions of Pd(OAc) 2 and a phosphine ligand L in tetrahydrofuran with RMgCl (R=Ph, Bn, Bu) as well as other organometallic reagents. Analysis of these model systems by electrospray- ionization mass spectrometry found palladate(II) complexes [L n PdR 3 ] - (n=0 and 1), thus pointing to the occurrence of transmetallation reactions. Upon gas-phase fragmentation, the [L n PdR 3 ] - anions preferentially underwent a reductive elimination to yield Pd 0 species. The sequence of the transmetallation and reductive elimination, thus, constitutes a feasible mechanism for the reduction of the Pd(OAc) 2 precatalyst. Other species of interest observed include the Pd IV complex [PdBn 5 ] - , which did not fragment via a reductive elimination but lost BnH instead. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

S1 new

Indian Academy of Sciences (India)

DMSO Release. ATRi Release. Only EdU. Only ATRi. *. *. *. n.s. n.s. B. 0. 10. 20. 30. 40. 50. 60. 15 mins 20 mins 30 mins 40 mins 60 mins. % o. f p. R a d. 1. 7 p o s tiv e c e lls. HU + DMSO. HU + ATRi. *. *. *. *. n.s. 0. 0. 20. 30. 40. 50. 60. 70. 80. 2 h Treatment. 24 h Treatment γ. H. 2. A. X. P o s i t i v e. N u c l e i. HU+DMSO ...

In-Flight Investigation of Large Airplane Flying Qualities for Approach and Landing

Science.gov (United States)

1981-09-01

Figure 55. SHORT AFT TAIL, HIGH q, X -P o Sol, 2𔃻 w .35, h/h NICHOLS PLOT 113 w= .33 r/a K = .0012 +q413 ccN Se OTFgue5 cv. a-T Fiue5.SOR F AL.X- IHq A S...274 T SnI ty G.q I n/a r equir -Zs I ve s PILOT B IC ATITD RESPONSE T SiAlG. I ti hd m r li RATING Long qnHi 92.5 A 4.2 1.0 .44 18 A haO t r SP Td y1...NU?4. COEFF.) F- - equivalent numerator zero, fixed at the true value of L or,- 0e or allowed to run free, I .sec -- ~ ~~ " " QIe -- " TD

Sınıf Öğretmeni Adaylarının Müzik Öğretimine İlişkin Tutumlarını Ölçmeye Yönelik Ölçek Geliştirme Çalışması A Study on Developing a Scale to Determine Classroom Teacher Candidate’s Attitudes towards Teaching Music

Directory of Open Access Journals (Sweden)

Sadullah Serkan ŞEKER

2013-09-01

birlikte sınıf öğretmeni de çocuğun yaşamında okulu ve öğretmenliği temsil eden bir bireydir. Çocuk bu dönemde sanat ve bilimle akademik anlamda iletişime geçer. Sanatın önemli kollarından bir tanesi de müziktir. Kalıcı, nitelikli, etkili bir müzik eğitiminin gerçekleşebilmesi için sınıf öğretmenlerinin temel bilgi ve beceriler, müzik öğretimiyle ilgili çağdaş yöntem ve yaklaşımlarına ilişkin kuramsal ve uygulamalı bilgilerin yanı sıra derse yönelik tutumları da önemlidir. Bu araştırmanın amacı sınıf öğretmenlerinin müzik öğretimiyle ilgili tutumlarını ölçmek amacıyla bir tutum ölçeği oluşturmaktır. Araştırma tarama yöntemi ile yürütülmüştür. Yapılan çalışmada yürütülen işlem basamakları; madde havuzu aşaması, kapsam geçerliği (uzman görüşü ve pilot uygulamanın yapılması olarak izlenmiştir. Ölçeğin pilot uygulaması Adnan Menderes Üniversitesi Eğitim Fakültesi İlköğretim Bölümü Sınıf Öğretmenliği Anabilim Dalı’nda öğrenim gören olan Müzik ve Müzik Öğretimi dersi almakta olan 282 öğrenciye uygulanmıştır. Analizler sonucunda elde edilen bulgular; verilerin faktör analizi için uygunluğunun belirlenmesi, taslak ölçeğin yapı geçerliğinin incelenmesi ve taslak ölçeğin güvenirliliğinin incelenmesi şeklinde sunulmuştur. Toplanan verilerin KMO (Kaiser-Meyer-Olkin katsayısı 0,92 Barlett testi sonucu ise 0.05’dir. 19 maddeden oluşan Müzik Öğretimine İlişkin Tutum Ölçeği’nin (MÖTÖ Cronbach Alfa güvenirlik katsayısı 0.90’dır.

Synthesis and evaluation of 1-[l brace]1-[5-(2'-[[sup 18]F]fluoroethyl)-2-thienyl]cyclohexyl[r brace]piperidine as a potential in vivo radioligand for the NMDA receptor-channel complex. [N-methyl-D-aspartate receptor

Energy Technology Data Exchange (ETDEWEB)

Orita, Kazuhiro; Sasaki, Shigeki; Maeda, Minoru [Kyushu Univ., Fukuoka (Japan). Faculty of Pharmaceutical Sciences; Hashimoto, Atsushi; Nishikawa, Toru [National Inst. of Neuroscience, Tokyo (Japan); Yugami, Tomoko; Umezu, Kohei [Mitsubishi Kasei Corp., Yokohama (Japan). Research Center

1993-10-01

1-[l brace]1-[5-(2'-[[sup 18]F]Fluoroethyl)-2-thienyl]cyclohexyl[r brace]piperidine ([sup 18]FE-TCP) was prepared a fluorine-substituted analogue of the potent NMDA receptor channel blocker, 1-[1-(2-thienyl)cyclohexyl]piperidine (TCP), by the mesylate displacement with [[sup 18]F]fluoride ion with isolated radiochemical yields of 6-12%, and the synthesis time including a two step HPLC purification was 120 min. The regional distribution in rat brain after i.v. injection of [sup 18]FE-TCP was heterogeneous and similar to the known distribution of phencyclidine recognition sites, with hippocampus-cerebellum, striatum-cerebellum and cerebral cortex-cerebellum concentration ratios of 2.08, 1.7 and 1.54, respectively, 15 min post-injection. Furthermore, this localized regional cerebral distribution was blocked by co-injection with the unlabelled FE-TCP or pretreatment with cis-2-hydroxymethyl-r-1-(N-piperidyl)-1-(2-thienyl)cyclohexane, with the greatest reductions seen in the hippocampus followed by the striatum and cerebral cortex. However, relatively low receptor binding affinity and high non-specific binding due to its high lipophilicity suggest that [sup 18]FE-TCP may not be a suitable radioligand for in vivo PET investigations of the NMDA receptor-channel complex. (Author).

N.M.R. study of organo-phosphorus compounds: non equivalence of methylenic protons in the {alpha} position of an asymmetric phosphorus atom. Application to study of coupling constants J{sub P,H} and J{sub H,H}; R.M.N. de composes organo-phosphores: non equivalence de protons methyleniques en {alpha} d'un phosphore asymetrique. Application a l'etude des constantes de couplage J{sub P,H} et J{sub H,H}

Energy Technology Data Exchange (ETDEWEB)

Albrand, J P [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

1969-07-01

Non-equivalent methylenic protons, with respect to an asymmetric center, have been observed in the n.m.r. spectra of some three- and tetra-coordinated phosphorus compounds. The analysis of these spectra yield the following results: in the studied secondary phosphines, the inversion rate at the phosphorus atom is slow on the n.m.r. time scale; the geminal coupling constant, for a free-rotating methylene group attached to a phosphorus atom, is negative; in phosphines the non equivalence of methylenic protons reveals two {sup 2}J{sub P-C-H} coupling constants which differ by about 5 Hz. This result is in agreement with previous studies on cyclic phosphines. In phosphine oxides, the {sup 2}J{sub P-C-H} values are negative. The {sup 3}J{sub H-P-C-H} coupling constant is positive in both phosphines and phosphine oxides. In phosphines, the non-equivalent methylenic protons exhibit two nearly equal values for this coupling constant. (author) [French] La non-equivalence de protons methyleniques observee dans quelques composes phosphores tricoordines et tetracoordines a apporte les resultats suivants, concernant la stereochimie et les constantes de couplage dans ces composes: dans les phosphines secondaires, la structure pyramidale des liaisons issues du phosphore est fixe a l'echelle de temps de mesure de la R.M.N.; la constante de couplage {sup 2}J{sub H-C-H}, pour un methylene en libre rotation en {alpha} d'un atome de phosphore, est negative; dans les phosphines etudiees, la non-equivalence. observee pour les protons methyleniques s'accompagne d'une difference importante (5 Hz) entre les deux constantes de couplage {sup 2}J{sub P-C-H} determinees par l'analyse; ce resultat est en accord avec la stereospecificite deja observee pour ce couplage dans les phosphines cycliques. Les valeurs observees pour {sup 2}J{sub P-C-H} dans les oxydes de phosphines sont negatives. Les valeurs de la constante de couplage {sup 3}J{sub H-P-C-H}, dans les phosphines et oxydes de phosphine

Effects of [3H]UdR on the cell-cycle progression of L1210 cells

International Nuclear Information System (INIS)

Darzynkiewicz, Z.; Carter, S.; Kimmel, M.

1984-01-01

Tritium-labelled uridine (( 3 H)UdR)perturbs progression of L1210 cells through the mitotic cycle. A slowdown of G 2 cells is observed 2 hr after addition of 0.5-5.0 μci/ml of ( 3 H)UdR into cultures. At 2.5-5.0 μCi/ml of ( 3 H)UdR a slowdown of cell progression through S is also apparent. Additionally, there is an increase in the number of cells with DNA values higher than 4C in cultures growing in the presence of ( 3 H)UdR for 8-24 hr. A pulse of ( 3 H)UdR of 2 hr duration labels predominantly (95%) cellular RNA. The first cell-cycle effects (G 2 slowdown) are observed when the amount of the incorporated ( 3 H)UdR is such that, on average there are fewer than thirty-six ( 3 H) decays per cell which corresponds to approximately 12-19 rads. The S-phase slowdown is seen at a dose of incorporated ( 3 H)UdR twice as high as that inducing G 2 effects. The specific localization of ( 3 H)UdR in nucleoli, peripheral nucleoplasm and in cytoplasm, as well as differences in the kinetics of the incorporation in relation to phases of the cell cycle are discussed. Mathematical modelling of the cell-cycle effects of ( 3 H)UdR is provided. (author)

Deleção 22q11.2 em pacientes com defeito cardíaco conotruncal e fenótipo da síndrome da deleção 22q11.2 Deleción 22q11.2 en pacientes con defecto cardiaco conotruncal y fenotipo del síndrome de la deleción 22q11.2 22q11.2 deletion in patients with conotruncal heart defect and del22q syndrome phenotype

Directory of Open Access Journals (Sweden)

Sintia Iole Nogueira Belangero

2009-04-01

Full Text Available FUNDAMENTO: A síndrome da deleção 22q11.2 é a mais freqüente síndrome de microdeleção humana. O fenótipo é altamente variável e caracterizado por defeito cardíaco conotruncal, dismorfias faciais, insuficiência velofaríngea, dificuldade de aprendizagem e retardo mental. OBJETIVO: O objetivo deste trabalho foi investigar a freqüência da deleção 22q11.2 em uma amostra brasileira de indivíduos portadores de cardiopatia conontrucal isolada e do fenótipo da síndrome da deleção 22q11.2. MÉTODOS: Vinte e nove pacientes foram estudados por meio de citogenética clássica, por hibridação in situ fluorescente (FISH e por técnicas moleculares. RESULTADOS: A análise citogenética por meio de bandamento G revelou cariótipo normal em todos os pacientes, com exceção de um que apresentou cariótipo 47,XX,+idic(22(q11.2. Com o uso de técnicas moleculares, a deleção foi observada em 25% dos pacientes, todos portadores do fenótipo da síndrome da deleção 22q11.2. Em nenhum dos casos, a deleção foi herdada dos pais. A freqüência da deleção 22q11.2 foi maior no grupo de pacientes portadores do espectro clínico da síndrome da deleção 22q11.2 do que no grupo de pacientes com cardiopatia conotruncal isolada. CONCLUSÃO: A investigação da presença da deleção e sua correlação com os dados clínicos dos pacientes podem auxiliar os pacientes e suas famílias a terem um melhor aconselhamento genético e um seguimento clínico mais adequado.FUNDAMENTO: El síndrome de la deleción 22q11.2 es el más frecuente síndrome de microdeleción humana. El fenotipo, altamente variable, se caracteriza por defecto cardiaco conotruncal, dismorfias faciales, insuficiencia velofaríngea, dificultad de aprendizaje y retardo mental. OBJETIVO: El objetivo de este trabajo fue investigar la frecuencia tanto de la deleción 22q11.2 en una muestra brasileña de individuos portadores de cardiopatía conotrucal aislada, como del fenotipo del s

L-allo-threonine aldolase with an H128Y/S292R mutation from Aeromonas jandaei DK-39 reveals the structural basis of changes in substrate stereoselectivity.

Science.gov (United States)

Qin, Hui-Min; Imai, Fabiana Lica; Miyakawa, Takuya; Kataoka, Michihiko; Kitamura, Nahoko; Urano, Nobuyuki; Mori, Koji; Kawabata, Hiroshi; Okai, Masahiko; Ohtsuka, Jun; Hou, Feng; Nagata, Koji; Shimizu, Sakayu; Tanokura, Masaru

2014-06-01

L-allo-Threonine aldolase (LATA), a pyridoxal-5'-phosphate-dependent enzyme from Aeromonas jandaei DK-39, stereospecifically catalyzes the reversible interconversion of L-allo-threonine to glycine and acetaldehyde. Here, the crystal structures of LATA and its mutant LATA_H128Y/S292R were determined at 2.59 and 2.50 Å resolution, respectively. Their structures implied that conformational changes in the loop consisting of residues Ala123-Pro131, where His128 moved 4.2 Å outwards from the active site on mutation to a tyrosine residue, regulate the substrate specificity for L-allo-threonine versus L-threonine. Saturation mutagenesis of His128 led to diverse stereoselectivity towards L-allo-threonine and L-threonine. Moreover, the H128Y mutant showed the highest activity towards the two substrates, with an 8.4-fold increase towards L-threonine and a 2.0-fold increase towards L-allo-threonine compared with the wild-type enzyme. The crystal structures of LATA and its mutant LATA_H128Y/S292R reported here will provide further insights into the regulation of the stereoselectivity of threonine aldolases targeted for the catalysis of L-allo-threonine/L-threonine synthesis.

A new monozoic tapeworm, Lobulovarium longiovatum n. g., n. sp. (Cestoda: Caryophyllidea), from barbs Puntius spp. (Teleostei: Cyprinidae) in the Indomalayan region

Czech Academy of Sciences Publication Activity Database

Oros, Mikuláš; Ash, Anirban; Brabec, Jan; Kar, P. K.; Scholz, Tomáš

2012-01-01

Roč. 83, č. 1 (2012), s. 1-13 ISSN 0165-5752 R&D Projects: GA ČR GD206/09/H026; GA ČR GA524/08/0885; GA ČR GBP505/12/G112 Institutional research plan: CEZ:AV0Z60220518 Keywords : MIXED MODELS * SILURIFORMES * PARASITES * IDENTIFICATION * CATOSTOMIDAE * MORPHOLOGY * CESTOIDEA * REVISION * SOPHORE * PISCES Subject RIV: GJ - Animal Vermins ; Diseases, Veterinary Medicine Impact factor: 1.260, year: 2012 http://link.springer.com/article/10.1007%2Fs11230-012-9367-6

Les infections urinaires chez les patients insuffisants rénaux chroniques hospitalisés au service de néphrologie: profil bactériologique et facteurs de risque

Science.gov (United States)

Chemlal, Abdeljalil; Ismaili, Fatiha Alaoui; Karimi, Ilham; Elharraqui, Ryme; Benabdellah, Nawal; Bekaoui, Samira; Haddiya, Intissar; Bentata, Yassamine

2015-01-01

L'infection urinaire chez l'insuffisant rénal est fréquente et particulière dans sa prise en charge diagnostique et thérapeutique. L'objectif de notre étude est de déterminer le profil bactériologique et d’étudier les facteurs de risque des infections urinaires chez le patient insuffisant rénal chronique en milieu de néphrologie. Etude prospective débutée en Septembre 2012 menée au service de néphrologie à l'hôpital régional d'Oujda de l'oriental Marocain. Ont été inclus tous les patients hospitalisés en néphrologie avec une infection urinaire documentée. Nous avons analysé les données démographiques, cliniques, biologiques, et thérapeutiques de nos patients à l'admission et au cours de leurs hospitalisations. 48 épisodes d'infections urinaires chez 43 patients ont été colligés dont 3 enfants. L'incidence de l'infection urinaire dans notre étude était de 4,65%. La médiane d’âge était de 53 (32-66) années. 60,4% étaient de sexe féminin. Le germe isolé était un Escheria Coli dans 58,3% et un Klebsiella dans 29,2%. Le germe isolé était résistant à l'amoxicilline-acide clavulanique dans 83% des cas. L'antibiotique prescris en premiére intention chez nos patients était une céphalosporine de 3 éme génération dans 50%. L’évolution chez nos patients était favorable dans 89,6% des cas. 33,3% avaient présenté un sepsis et on a noté le décès dans 10,4% des cas. Les infections urinaires chez l'insuffisant rénal chronique reste très grave vu leur lourde morbi-mortalié d'où l'intêrét d'un dépistage précoce chez cette population. Un usage raisonné des antibiotiques est nécessaire afin de prévenir l'extension des résistances bactériennes. PMID:26213601

Estudio de la psicopatología en una población de pacientes con microdeleción 22q11.2

OpenAIRE

Robles Sánchez, Fuensanta

2016-01-01

El síndrome de deleción 22q11.2 (22q11.2 DS; OMIM # 188400) es un trastorno genético que puede presentar diversas malformaciones físicas, déficit cognitivo y trastornos psicopatológicos. Los objetivos del estudio han consistido en evaluar el nivel de inteligencia y los trastornos psiquiátricos de los pacientes con este síndrome en la etapa infanto-juvenil y determinar los factores genéticos, clínicos y sociodemográficos asociados. Hemos estudiado el perfil cognitivo y los trastornos psi...

Social media – En marknadsföringsplan för Arcada Entrepreneurship Society

OpenAIRE

Simberg, Per

2015-01-01

Syfte med studien är att utarbeta en marknadsföringsplan i sociala medierna för Arcada Entrepreneurship Society, där man tar fram nuläget och vilka målen är för Arcada Entrepreneurship Society i sociala medierna och hur de skall nå målen. Marknadsföring på sociala medier kräver att man vet vilka sociala medier man behöver för att få fram sitt budskap och hur man skapar en synlighet för sig som Företag/Förening. Det är även viktigt att tänka på vilket innehåll man lägger ut samt när och på...

S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model

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Pingting Liu

2017-01-01

Full Text Available The S113R mutation (c.339T>G (MIM #603690.0001 in SLC33A1 (MIM #603690, an ER membrane acetyl-CoA transporter, has been previously identified in individuals with hereditary spastic paraplegia type 42 (SPG42; MIM #612539. SLC33A1 has also been shown to inhibit the bone morphogenetic protein (BMP signaling pathway in zebrafish. To better understand the function of SLC33A1, we generated and characterized Slc33a1S113R knock-in mice. Homozygous Slc33a1S113R mutant mice were embryonic lethal, whereas heterozygous Slc33a1 mutant mice (Slc33a1wt/mut exhibited behavioral abnormalities and central neurodegeneration, which is consistent with hereditary spastic paraplegia (HSP phenotypes. Importantly, we found an upregulation of BMP signaling in the nervous system and mouse embryonic fibroblasts of Slc33a1wt/mut mice. Using a sciatic nerve crush injury model in vivo and dorsal root ganglion (DRG culture in vitro we showed that injury-induced axonal regeneration in Slc33a1wt/mut mice was accelerated and mediated by upregulated BMP signaling. Exogenous addition of BMP signaling antagonist, noggin, could efficiently alleviate the accelerated injury-induced axonal regrowth. These results indicate that SLC33A1 can negatively regulate BMP signaling in mice, further supporting the notion that upregulation of BMP signaling is a common mechanism of a subset of hereditary spastic paraplegias.

The R.D.F. gasifier of Florentine area

Energy Technology Data Exchange (ETDEWEB)

Barducci, G. [Studio Tecnico di Ingegneria Ambientale, Firenze (Italy)

1993-12-31

L.E.G. (Low Energy Gas) from large biomass gasification plants, to be used as a fuel for electricity production, is a suitable means for adding value -- from an energetic point of view -- to the R.D.F. (Refuse Derived Fuel) and to the agricultural and forestry residues. R.D.F. can be converted to a clean gas turbine fuel by gasification that consists in a partial combustion with oxygen or air and steam. In that sense it seems worthwhile to analyze the capacity of a gasifier such as the Greve in Chianti`s recirculating fluidized bed gasifier. The world`s first full-scale R.D.F. gasification plant has been designed in Florence; it is now realized in Greve in Chianti and, at the moment, is starting the industrial management. The plant is designed to gasify 200 t/d of pelletized R.D.F. producing about 17.000/19.000 Nmc/h of low energy gas (LEG) with a net calorific value (NCV) of about 5 MJ/Nmc and a total energy content (at the outlet of the gasifiers) of about 7.5 MJ/Nmc. The produced LEG will be partly burned on site for power production while partly will be cooled, dedusted and transported to the kiln of the adjacent cement factory. The design idea of R.D.F. gasification starts from field of waste treatment and recycling and develops new, advanced technical and economical sinergy with the field of industrial production and electric power generation. The gasification of fuels derived from selected wastes (and/or industrial refuse) and the exploitation of the lean gas produced is the most advanced point in the development of heat conversion processes.

A REVIEW OF 3200 CASES 0F HERNIATED LUMBAR DISC

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A. ALIMOHAMMADI

1987-05-01

Full Text Available I t 1S a t t emted t o reV1ew 3200 c a s e s of herniat ed lumbar d isc t o point out the i ndic a tions for ope ra t i o n , the value o f myelog raphy . t he r esult o f ope rat ion and the caus e s o f comp l i cat i ons . We believe tha t myelography s houl d be performed i n a l most a ll patients. I n ne a rl y"n96 .8 pe rcent of cases my e l o grams co r r e s pond to clinical f i ndings. In general when there is clear s igns and s ympt oms of dis c disease , con fi rmed r adiolo gically, i n the hand of an e xpo r t surgeon. in 93 percent the result will be excel e nt .

MIR’ÂTÜ’L-AHLÂK BY BOSTANZÂDE YAHYÂ EFENDI BOSTANZÂDE YAHYÂ EFENDİ’NİN MİR’ÂTÜ’L-AHLÂK ADLI ESERİ

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Nurgül SUCU

2011-06-01

Full Text Available Mir’âtü’l-Ahlâk by Bostanzâde Yahyâ Efendi, a seventeenth century author, is a prose type and didactic book of morals consisting of twenty-four chapters, each dealing with an aspect of morals from a religious, mystical and philosophical perspective. The topics that the book handles include virtues such as prayers, patience, thankfulness, bravery, intelligence, seriousness, consent, loyalty, secretiveness, generosity, forgiveness, chastity, modesty, coyness, confidence, compassion, protectiveness, consultation, softness of manner, industriousness, foresight, seizing opportunity, caution, establishing good rapport with the good, and abiding by the law and obligations originating from official duties such as emirate, vizierdom, governorship and kingdom. The book contains Arabic, Persian and Turkish poetry of moral and judgmental nature between sentences, is embellished with exemplary parables from prophets’ lives and Islamic history and makes quotations from prominent philosophers and scholars such as Plato, Avicenna and Hüseyin Vâiz-i Kâshifî. The book contains 854 poems and 113 parables. In this study, describes major aspects of Mir’âtü’l-Ahlâk by Bostanzâde Yahyâ Efendi, focuses on its contents of chapters On yedinci yüzyıl müelliflerinden Bostanzâde Yahyâ Efendi’nin Mir’âtü’l-Ahlâk adlı eseri; yirmi dört bölümden oluşan ve her bölümde ahlak bahislerinden birinin ele alındığı, dinî-tasavvufi-felsefi cepheleri bulunan, mensur ve didaktik bir ahlak kitabıdır. Eserde işlenen konular; ibadet, sabır, şükür, şecaat, zekâ, ciddiyet, rıza, vefa, sır saklama, cömertlik, af, iffet, tevazu, hayâ, emanet, sadakat, şefkat, alicenaplık, müşavere, hilm, gayret, feraset, fırsatı değerlendirme, temkin, iyilerle dostluk kurma, hukuka riayet gibi faziletler ve hükümdarlık, emirlik, vezirlik, valilik gibi resmî görevlerin gerektirdiği yükümlülüklerdir. Cümle aralarında Arap

CONTRIBUTION A L'ETUDE DE LA DISTOMATOSE HEPATIQUE EN IRAN: RAPPORT DE DEUX CAS DE DISTOMATOSE OPERES COMME CAS DE LITHIASE BILIAIRE

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SEYED FARSHI DJALAL

1985-05-01

Full Text Available The a ut ho rs e xpl ain and review " very br iefly the Dis t omatosis i n human and animals . They f ound out that t h i s par a s ite is p resent i n Ovine i n a wide r ange i n I ran . This zoonosis and human contami na t ion from a ni ma ls (Fixed or freely f l oa t i ng metacercaria e l ma i n l y s heep , s houl d be mor e pr e valent in Iran and neighbouring CQunt r ies , with a hyg ienic and a s ocia economic i mportanc e, where people are a c c us t umed to eat crude vegetables . The authors observed t .....o cases of Human Fasciolosis due t o F . hepatica , describing symptomes, confused with common bile duct s tan . The y r ecomme nd an i nt e nse and treatment of main s ucepti ble animals regul a r l y and e a r l y det e ction and tre atmen t of infes tatio n in human.

High-Accuracy Global Time and Frequency Transfer with a Space-Borne Hydrogen Maser Clock

Science.gov (United States)

1982-12-01

of t h e s p a c e c l o c k is modu la t ed on t h e c l o c k downl ink car r ie r using PRN p h a s e modula- t i o n (5). The s p a...is t o a c c o u n t f o r r e la t i s t i c e f f e c t s w i t h i n a f r a c t i o n a l f r e q u e n c y error of 0 . T h i s r...Mockler , and J . M . R ichardson , Metrologia , 1, p. 114, 1965. ( 1 3 ) Glaze, D . J . , Helmut Hellwig, Steve J a r v i s , J r . , A

PCR-Independent Detection of Bacterial Species-Specific 16S rRNA at 10 fM by a Pore-Blockage Sensor

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Leyla Esfandiari

2016-07-01

Full Text Available A PCR-free, optics-free device is used for the detection of Escherichia coli (E. coli 16S rRNA at 10 fM, which corresponds to ~100–1000 colony forming units/mL (CFU/mL depending on cellular rRNA levels. The development of a rapid, sensitive, and cost-effective nucleic acid detection platform is sought for the detection of pathogenic microbes in food, water and body fluids. Since 16S rRNA sequences are species specific and are present at high copy number in viable cells, these nucleic acids offer an attractive target for microbial pathogen detection schemes. Here, target 16S rRNA of E. coli at 10 fM concentration was detected against a total RNA background using a conceptually simple approach based on electromechanical signal transduction, whereby a step change reduction in ionic current through a pore indicates blockage by an electrophoretically mobilized bead-peptide nucleic acid probe conjugate hybridized to target nucleic acid. We investigated the concentration detection limit for bacterial species-specific 16S rRNA at 1 pM to 1 fM and found a limit of detection of 10 fM for our device, which is consistent with our previous finding with single-stranded DNA of similar length. In addition, no false positive responses were obtained with control RNA and no false negatives with target 16S rRNA present down to the limit of detection (LOD of 10 fM. Thus, this detection scheme shows promise for integration into portable, low-cost systems for rapid detection of pathogenic microbes in food, water and body fluids.

One-electron capture into Li-like autoionising N4+ (1s2ln'l') configurations by metastable N5+ (1s2s3S) multicharged ions in collisions with He and H2, observed by electron spectrometry at 3.4 keV amu-1

International Nuclear Information System (INIS)

Bordenave-Montesquieu, A.; Benoit-Cattin, P.; Gleizes, A.

1985-01-01

One-electron capture into N 4+ (1s2ln'l') configurations, with n'=2 to 4, has been observed by electron spectrometry when a N 5+ (1s2s 3 S) multicharged ion beam encounters an He or H 2 target, at low collision velocity (upsilon=0.37 au) within single-collision conditions. Contributions of other 1s2l metastable states and of the 1s 2 ground state may be disregarded. A small indication of two-electron capture by 1s2s 3 S ions into (1s2s 3 S)3l3l' configurations is also seen. (author)

Weldability of dissimilar joint between F82H and SUS316L under fiber laser welding

Energy Technology Data Exchange (ETDEWEB)

Serizawa, Hisashi [Joining and Welding Research Institute, Osaka University, 11-1 Mihogaoka, Ibaraki, Osaka 567-0047 (Japan); Mori, Daiki; Shirai, Yuma; Ogiwara, Hiroyuki; Mori, Hiroaki [Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871 (Japan)

2013-10-15

Highlights: • The microstructure of F82H/SUS316L dissimilar joint can be divided into four regions. • In the case without beam position shift, hardness of WM cannot be reduced by PWHT. • The fiber laser welding would be applicable for constructing the dissimilar joint. -- Abstract: As one of the high beam quality heat sources, 4 kW fiber laser was applied for joining between reduced activation ferritic/martensitic steel, F82H and SUS316L austenitic stainless steel, and the microstructural analyses and Vickers hardness measurements were carried out before and after post-weld heat treatment (PWHT). The microstructure of joint can be divided into four regions which are base metal of F82H, heat affected zone (HAZ) in F82H, weld metal (WM) and base metal of SUS316L. Also, it is revealed that the high-power fiber laser can be employed for constructing butt joint between F82H and SUS316L by applying PWHT and shifting the laser beam position to SUS316L, where the distance between the contact face and beam should be set as a range from radius to diameter of laser beam.

Weldability of dissimilar joint between F82H and SUS316L under fiber laser welding

International Nuclear Information System (INIS)

Serizawa, Hisashi; Mori, Daiki; Shirai, Yuma; Ogiwara, Hiroyuki; Mori, Hiroaki

2013-01-01

Highlights: • The microstructure of F82H/SUS316L dissimilar joint can be divided into four regions. • In the case without beam position shift, hardness of WM cannot be reduced by PWHT. • The fiber laser welding would be applicable for constructing the dissimilar joint. -- Abstract: As one of the high beam quality heat sources, 4 kW fiber laser was applied for joining between reduced activation ferritic/martensitic steel, F82H and SUS316L austenitic stainless steel, and the microstructural analyses and Vickers hardness measurements were carried out before and after post-weld heat treatment (PWHT). The microstructure of joint can be divided into four regions which are base metal of F82H, heat affected zone (HAZ) in F82H, weld metal (WM) and base metal of SUS316L. Also, it is revealed that the high-power fiber laser can be employed for constructing butt joint between F82H and SUS316L by applying PWHT and shifting the laser beam position to SUS316L, where the distance between the contact face and beam should be set as a range from radius to diameter of laser beam

Spread-F occurrences and relationships with foF2 and h'F at low- and mid-latitudes in China

Science.gov (United States)

Wang, Ning; Guo, Lixin; Zhao, Zhenwei; Ding, Zonghua; Lin, Leke

2018-04-01

Ionospheric irregularities are an important phenomenon in scientific studies and applications of radio-wave propagation. Spread-F echoes in ionograms are a type of high-frequency band irregularities that include frequency spread-F (FSF), range spread-F (RSF), and mixed spread-F (MSF) events. In this study, we obtained spread-F data from four ionosondes at low- and mid-latitudes near the 120°E chain in China during the 23rd solar cycle. We used these data to investigate spread-F occurrence percentages and variations with local time, season, latitude, and solar activity. The four ionosondes were located at Haikou (HK) (20°N, 110.34°E), Guangzhou (GZ) (23.14°N, 113.36°E), Beijing (BJ) (40.11°N, 116.28°E), and Changchun (CC) (43.84°N, 125.28°E). We also present possible correlations between spread-Fs and other ionospheric parameters, such as the critical frequency of the F2-layer (foF2) and the virtual height of the bottom-side F-layer (h'F). In particular, we investigated the possible threshold of the foF2 affecting the FSF and the relationship between the h'F and the RSF. The main conclusions are as follows: (a) the FSF occurrence percentages were anti-correlated with solar activity at all four sites; meanwhile, RSF occurrence rates increased with the increase in solar activity at HK, but not at the other three sites; (b) FSF occurrence rates were larger at the mid-latitudes than expected, while FSFs occurred more often after midnight; (c) the highest FSF occurrence rates mostly appeared during the summer months, while RSFs occurred mostly in the equinoctial months of 2000-2002 at HK and GZ; (d) a lower foF2 was suitable for FSF events; nevertheless, h'F and RSF occurrences satisfied the parabolic relationship; (e) the foF2 thresholds for FSFs were 15, 14, 7.6, and 7.8 MHz at HK, GZ, BJ, and CC, respectively. The h'Fs occurring between 240 and 290 km were more favorable for RSF occurrences. These results are important for understanding ionospheric

Sådan læres praktiske færdigheder i færdighedslaboratorium

DEFF Research Database (Denmark)

Riemenschneider, Anni Vester; Møller, Else

2012-01-01

. Modellen give rde studerende en opfattelse af sikkerhed, når deres udførelse bliver evalueret på baggrund af modellens komponenter. Videooptagelserne viser, at undervisningen i praktiske færdigheder omfatter den kompleksitet som praktiske færdigheder rummer og som modellen lægger op til. Analyse af...

Osmanlı Mühür Sanatı Ve Klasik Türk Şiirinde Mühür The Ottoman Art Of Seals And Seals In The Classical Turkish Poetry

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Semra TUNÇ

2013-03-01

istif edildiği mühürler mevcuttur. Mühürcülük Osmanlı’da başlı başına bir sanat olarak kabul edilmiştir. Mühür ustaları; sülüs, ta’lîk, nesih, rik’a, reyhanî gibi yazı çeşitlerinden bir ya da birkaçında ustalık kazanmak zorundaydı. Ayrıca yazıların sert bir malzeme üzerine estetik bir düzenle, ters ve ancak okunabilecek büyüklükte kazınması büyük maharet, sabır ve dikkat gerektiren zor bir işti. Bu yüzden mühür ustaları mührün bir kenarına ince bir yazıyla kendi adlarını kazırlardı.Mühür kazma işine hakkâklik; bu işi yapana da hakkâk, mühür kesen gibi isimler verilirdi. Osmanlı toplumunda hakkâklik itibarlı bir meslek olarak kabul edilirdi. Zira bu mesleği icra edenler hem kabiliyetli, sanatkâr insanlar hem de asla sahtekârlık yapmayan, güvenilir insanlardı. Ayrıca resmî veya özel bütün işlerde mühür kullanılması, mührün sosyal hayattaki önemi, padişahların bu sanatı himaye etmeleri, hatta II. Mahmut gibi bazı sultanların bizzat mühür kazımaları mesleğin itibarını artırmıştır.Mühürler; mühr-i hümâyûn, şahsî mühürler, vakıf mühürleri ve resmî mühürler gibi kullanım amacına ve kullanan şahsa göre tasnif edilir. Yapıldığı malzeme, sanat değeri açısından da mühürler farklılık gösterir. Örneğin, padişahların biri zümrüt, üçü altın olmak üzere dört mührü olurdu. Mühürler genellikle şekilce birbirine benzer. Ancak mühr-i hümâyûnlar küçük beyzî (oval, daire, kare veya köşeleri kesik kare (sekizgen; vezir, beylerbeyi gibi üst düzey yöneticilerin mührü beyzî veya yuvarlaktır.Mühür; Osmanlı toplum hayatının tüm özellikleriyle bir ayna gibiaksettiği alan olan klasik Türk şiirine de malzeme olmuştur. Bu sebepleOsmanlı Devleti’yle ilgili çalışmalarda güvenilir bir kaynak olan şiirdemühür ve mühür sanatı ihmal edilmemesi gereken bir konudur. KlasikTürk şiirinde; mühür çeşitleri, �

Twitter a­-t­-il bousculé le droit parlementaire ? : Le jour où le #directAN s'est invité dans l'hémicycle

OpenAIRE

Chibois , Jonathan

2014-01-01

International audience; En février 2013, lors de l'examen à l'Assemblée nationale du projet de loi sur l'ouverture du mariage aux couples de même sexe, l'agitation est telle sur Twitter que, au quatrième jour de délibération, la séance publique dans l'hémicycle est levée pour quelques minutes. À plusieurs reprises ensuite, fréquentes sont les allusions à des échanges de tweets entre députés, jugés inappropriés, pour lesquels sera demandée, sans succès, une régulation du président de séance. L...

Differential uptake of [18F]FET and [3H]L-methionine in focal cortical ischemia

International Nuclear Information System (INIS)

Salber, Dagmar; Stoffels, Gabriele; Pauleit, Dirk; Reifenberger, Guido; Sabel, Michael; Shah, Nadim Jon; Hamacher, Kurt; Coenen, Heinz H.; Langen, Karl-Josef

2006-01-01

Amino acids such as [ 11 C-methyl]L-methionine are particularly useful in brain tumor diagnosis, but unspecific uptake (e.g., in cerebral ischemia) has been reported. O-(2-[ 18 F]fluoroethyl)-L-tyrosine ([ 18 F]FET) shows a clinical potential similar to that of L-methionine (MET) in brain tumor diagnosis but is applicable on a wider clinical scale. The aim of this study was to evaluate the uptake of [ 18 F]FET and [ 3 H]MET in focal cortical ischemia in rats by dual-tracer autoradiography. Methods: Focal cortical ischemia was induced in 25 CDF rats using the photothrombosis (PT) model. At different time points up to 6 weeks after the induction of PT, [ 18 F]FET and [ 3 H]MET were injected intravenously. Additionally, contrast-enhanced magnetic resonance imaging (MRI) was performed in 10 animals. One hour after tracer injection, brains were cut in coronal sections and evaluated by dual-tracer autoradiography. Lesion-to-brain (L/B) ratios were calculated by dividing the maximal uptake in the lesion by the mean uptake in the brain. An L/B ratio of >2.0 was considered indicative of pathological uptake. Histological slices were stained by cresyl violet and supplemented by immunostainings for glial fibrillary acidic protein (GFAP) and CD68 in selected cases. Results: A variably increased uptake of both tracers was observed in the PT lesion and its demarcation zone up to 7 days after PT for [ 18 F]FET and up to 6 weeks for [ 3 H]MET. The cutoff level of 2.0 was exceeded in 12/25 animals for [ 18 F]FET and in 18/25 animals for [ 3 H]MET. Focally increased tracer uptake matched contrast enhancement in MRI in 3/10 cases for [ 18 F]FET and in 5/10 cases for [ 3 H]MET. Immunohistochemical staining in lesions with differential uptake of [ 18 F]FET and [ 3 H]MET revealed that selective uptake of [ 18 F]FET was associated with GFAP-positive astrogliosis while selective [ 3 H]MET uptake correlated with CD68-positive macrophage infiltration. Conclusions: [ 18 F]FET, like [ 3 H

Radiolabeling and in vitro and in vivo characterization of [18F]FB-[R(8,15,21), L17]-VIP as a PET imaging agent for tumor overexpressed VIP receptors.

Science.gov (United States)

Cheng, Dengfeng; Yin, Duanzhi; Li, Gucai; Wang, Mingwei; Li, Shiqiang; Zheng, Mingqiang; Cai, Hancheng; Wang, Yongxian

2006-12-01

In an effort to develop a peptide-based radiopharmaceutical for the detection of tumors overexpressed vasoactive intestinal peptide receptors with positron emission tomography, we have prepared a novel [R(8,15,21), L17]-VIP peptide for 18F-labeling. This peptide inhibited 125I-VIP binding to rats lung membranes with high affinity [half-maximal inhibitory concentrations (IC50) of 0.12 nm]. Additionally, [R(8,15,21), L17]-VIP showed higher stability than native vasoactive intestinal peptide in vivo of mice. With N-succinimidyl 4-[18F] fluorobenzoate as labeling prosthetic group, [18F]FB-[R(8,15,21), L17]-VIP was obtained in >99% radiochemical purity within 100 min in decay-for-corrected radiochemical yield of 33.6 +/- 3% (n = 5) and a specific radioactivity 255 GBq/micromol at the end of synthesis. Stability of [18F]FB-[R(8,15,21), L17]-VIP in vitro and in vivo were investigated. Biodistribution of this trace was carried out in mice with induced C26 colorectal tumor. Fast clearance of [18F]FB-[R(8,15,21), L17]-VIP from non-target tissues and specific uptakes by tumors realized higher tumor-to-muscle ratio (3.55) and tumor-to-blood ratio (2.37) 60 min postinjection. Clear difference was observed between the blocking and unblocking experiments in biodistribution and whole body radioautography. [18F]FB-[R(8,15,21), L17]-VIP has demonstrated its potential for diagnosing tumors overexpressed vasoactive intestinal peptide receptors both in vitro and in vivo.

~ i t i d e r m a t o ~ h ~ t i c Activities of Nine (9) Essential Oils J.R. ...

African Journals Online (AJOL)

i t i d e r m a t o ~ h ~ t i c Activities of Nine (9) Essential Oils. J.R. KUIATE", S.P. KUATE'.~, N.E. KEMADJOU~, S. DJOKOUA~, F. ZIFACK~ AND J. ~. 0. ~. 0. ~. I Department of Biochemistry, FS, University of Dschang, P.O. Box 67 Dschang, Cameroon. 2~epartment of Biochemistry, FS, University of Yaoundt!, P.O. Box 812 ...

Effects of (/sup 3/H)UdR on the cell-cycle progression of L1210 cells

Energy Technology Data Exchange (ETDEWEB)

Darzynkiewicz, Z.; Carter, S.; Kimmel, M. (Memorial Sloan-Kettering Cancer Center, New York (USA))

1984-11-01

Tritium-labelled uridine ((/sup 3/H)UdR)perturbs progression of L1210 cells through the mitotic cycle. A slowdown of G/sub 2/ cells is observed 2 hr after addition of 0.5-5.0 ..mu..ci/ml of (/sup 3/H)UdR into cultures. At 2.5-5.0 ..mu..Ci/ml of (/sup 3/H)UdR a slowdown of cell progression through S is also apparent. Additionally, there is an increase in the number of cells with DNA values higher than 4C in cultures growing in the presence of (/sup 3/H)UdR for 8-24 hr. A pulse of (/sup 3/H)UdR of 2 hr duration labels predominantly (95%) cellular RNA. The first cell-cycle effects (G/sub 2/ slowdown) are observed when the amount of the incorporated (/sup 3/H)UdR is such that, on average there are fewer than thirty-six (/sup 3/H) decays per cell which corresponds to approximately 12-19 rads. The S-phase slowdown is seen at a dose of incorporated (/sup 3/H)UdR twice as high as that inducing G/sub 2/ effects. The specific localization of (/sup 3/H)UdR in nucleoli, peripheral nucleoplasm and in cytoplasm, as well as differences in the kinetics of the incorporation in relation to phases of the cell cycle are discussed. Mathematical modelling of the cell-cycle effects of (/sup 3/H)UdR is provided.

Dubbel ABC-analys av inrednings- och gåvoartiklar för en blombutik

OpenAIRE

Ruokolainen, Daniela

2016-01-01

Kirkkonummen Kukkapiste är en blombutik i Kyrkslätt centrum, som år 2012 utvidgade sitt sortiment av inrednings- och gåvoartiklar. Konkurrensen är hög och en ABC-analys kan hjälpa företagare att identifiera vilka faktorer i ett företag som det lönar sig att lägga tid och resurser på, vilket i sin tur effektiverar verksamheten. Syftet med detta arbete är att med hjälp av en dubbel ABC-analys för Kirkkonummen Kukkapiste ta reda på vilka inrednings- och gåvoartiklar som binder mest kapital och v...

Plasmas pour valorisation totale ou partielle des gaz contenant de l'H2S Plasmas for Total Or Partial Upgrading of H2s Containing Gases

Directory of Open Access Journals (Sweden)

Czernichowski A.

2006-12-01

Full Text Available Des procédés par plasmas alternatifs au procédé Claus sont proposés pour produire de l'hydrogène et récupérer du soufre à partir des gaz contenant une forte teneur en H2S. Quand la teneur en H2S est moins importante, des techniques plasma peuvent également être utiles pour assister certains étages du procédé classique Claus ou réaliser ce procédé pour des gaz non conventionnels. Les tests allant jusqu'à l'échelle industrielle sont menés dans divers réacteurs à plasmas et les résultats encourageants rapportés de la littérature et de la recherche propre laissent envisager des prochaines applications. Plasma assisted processes are proposed to act as an alternative to the Claus process in order to recover hydrogen and sulphur from high H2S gases. For less concentrated gases plasma techniques may also be inserted into classical Claus plant or may allow treatment of non conventional gases. Up to industrial scale tests are performed using different plasma reactors. The literature-based results as well as our own ones make the future applications quite optimistic.

Revisiting van der Waals like behavior of f(R AdS black holes via the two point correlation function

Directory of Open Access Journals (Sweden)

Jie-Xiong Mo

2017-05-01

Full Text Available Van der Waals like behavior of f(R AdS black holes is revisited via two point correlation function, which is dual to the geodesic length in the bulk. The equation of motion constrained by the boundary condition is solved numerically and both the effect of boundary region size and f(R gravity are probed. Moreover, an analogous specific heat related to δL is introduced. It is shown that the T−δL graphs of f(R AdS black holes exhibit reverse van der Waals like behavior just as the T−S graphs do. Free energy analysis is carried out to determine the first order phase transition temperature T⁎ and the unstable branch in T−δL curve is removed by a bar T=T⁎. It is shown that the first order phase transition temperature is the same at least to the order of 10−10 for different choices of the parameter b although the values of free energy vary with b. Our result further supports the former finding that charged f(R AdS black holes behave much like RN-AdS black holes. We also check the analogous equal area law numerically and find that the relative errors for both the cases θ0=0.1 and θ0=0.2 are small enough. The fitting functions between log⁡|T−Tc| and log⁡|δL−δLc| for both cases are also obtained. It is shown that the slope is around 3, implying that the critical exponent is about 2/3. This result is in accordance with those in former literatures of specific heat related to the thermal entropy or entanglement entropy.

Stakes of a cooperation: preliminary inquiry led with the C.L.I. and I.R.S.N; Enjeux d'une cooperation: enquete prealable menee aupres de CLI et de l'IRSN

Energy Technology Data Exchange (ETDEWEB)

Gadbois, S. [MUTADIS, 75 - Paris (France); Vaillant, L. [Centre d' Etude sur l' Evaluation de la Protection dans le Domaine Nucleaire, 92 - Fontenay aux Roses (France)

2004-07-01

The national association of local commissions of information (A.N.C.L.I.) and the institute of radiation protection and nuclear safety (I.R.S.N.) agreed to define experimental actions for year 2004 within the framework of their protocol concerning the scientific and technical support brought by the institute to the local commissions of information (C.L.I) in this perspective, both organizations wished beforehand to realize an inquiry on the expectations of the C.L.I. and the I.R.S.N. in follow-up of release and surveillance of the nuclear installations environment. The present document reports objectives and methodology of the inquiry, results obtained notably by underlining the identified problems and the actions suggested to remedy it. (N.C.)

Hydrazinium(1+) hexafluorotitanate(IV), 2N[sub 2]H[sub 5][sup +]. TiF[sub 6][sup 2-]. [N[sub 2]H[sub 5]TiF[sub 6

Energy Technology Data Exchange (ETDEWEB)

Leban, I. (Dept. of Chemistry and Chemical Technology, Univ. Ljubljana (Slovenia))

1994-06-15

The crystals exhibit racemic twinning. The structure consists of hydrazinium(1+), N[sub 2]H[sub 5][sup +], cations and usual octahedral hexafluorotitanate(IV) anions. They are linked together via hydrogen bonds of the types N-H..F and N-H..N. (orig.).

Genome Sequence of the Biocontrol Strain Pseudomonas fluorescens F113

Science.gov (United States)

Redondo-Nieto, Miguel; Barret, Matthieu; Morrisey, John P.; Germaine, Kieran; Martínez-Granero, Francisco; Barahona, Emma; Navazo, Ana; Sánchez-Contreras, María; Moynihan, Jennifer A.; Giddens, Stephen R.; Coppoolse, Eric R.; Muriel, Candela; Stiekema, Willem J.; Rainey, Paul B.; Dowling, David; O'Gara, Fergal; Martín, Marta

2012-01-01

Pseudomonas fluorescens F113 is a plant growth-promoting rhizobacterium (PGPR) that has biocontrol activity against fungal plant pathogens and is a model for rhizosphere colonization. Here, we present its complete genome sequence, which shows that besides a core genome very similar to those of other strains sequenced within this species, F113 possesses a wide array of genes encoding specialized functions for thriving in the rhizosphere and interacting with eukaryotic organisms. PMID:22328765

Dömda att leva i skuggan : En kvalitativ intervjustudie om hälsan hos personer med albinism i Rwanda, utifrån begreppen diskriminering, coping och socialt stöd

OpenAIRE

Niyonkuru, Elsie Diane

2016-01-01

Bakgrund: Oculocutaneous albinism (OCA) är en ärftlig sjukdom som fysiskt, psykiskt och socialt påverkar de drabbade individerna. Okunskap, fördomar och myter om albinism utgör de största orsakerna till den diskriminering som personer med albinism utsatts för särskilt i vissa länder i Afrika söder om Sahara. Syfte: Syftet är att beskriva hälsan hos personer med albinism i Rwanda, utifrån begreppen diskriminering, coping och socialt stöd. Metod: En kvalitativ metod med induktiv ansats ligger t...

Akademik Başarının Arttırılmasında Aile Katılımı

Directory of Open Access Journals (Sweden)

Bahar Keçeli-Kaysılı

2008-01-01

Full Text Available Çocukların başarılarının arttırılmasını amaçlayan aile katılımı, ailelerin konuya özgü becerileri öğrenmelerinden aile içinde uygun ilişkilerin geliştirilmesine kadar pek çok becerinin kazandırılmasını kapsamaktadır. Aile katılımının her ne kadar yasalarda geçen hükümlerle gerekliliği belirlenmiş olsa da uygulama alanında günümüzde halen pek çok ülke için katılımın sağlanması güç olmaktadır. Alan yazında aile katılımının akademik başarıya etkisine yönelik birbiriden farklı sonuçlarla karşılaşılmıştır. Bunun nedeni aile katılımı kavramının, pek çok değişkeni barındırıyor olması ve bu kavramın farklı şekillerde tanımlanıyor olmasıdır. Her ne kadar aile katılımının hangi bileşeninin akademik başarıya etki ettiği açıkça ortaya konulamasa da araştırma bulguları aile katılımının öğrencilerin akademik becerilerini arttırdığını göstermektedir. Bu alan yazın taramasında aile katılımı ve akademik başarı tanımlanmış, aile katılımını engelleyen etmenler, açıklanmaya çalışılmıştır. Aile katılımının akademik başarıya etkisini gösteren çalışmalara ayrıntılı olarak yer verilmiş, bu çalışmaların bulduğu farklı sonuçlar ve nedenleri tartışılmıştır. Aile katılımının sağlanması, ekolojik bakış açısı ve sistem yaklaşımı bağlamında ele alınarak, okul açısından aile katılımını destekleyici stratejilere değinilmiştir. Parental involvement, which aims to increase the academic achievement of children, encompasses a wide of range of skills from the families’ learning the relevant skills to the development of appropriate relationships within the family. Although the need for parental involvement is stipulated by clauses in various laws, in practice, participation is not fully established yet in many countries. The literature of the field has various findings regarding the impact of

Decapado de un acero inoxidable austenítico mediante mezclas ecológicas basadas en H2O2 - H2SO4 - iones F-

Directory of Open Access Journals (Sweden)

Narváez, L.

2013-04-01

Full Text Available This study reports the pickling of 316L stainless steel using mixtures of hydrogen peroxide (H2O2, sulphuric acid (H2SO4 and fluoride ions as hydrofluoric acid (HF, sodium fluoride (NaF and potassium fluoride (KF. The decomposition of H2O2 in the mixtures was assessed at different temperatures 25 °C to 60 °C, with ferric ion contents from 0 to 40 g/l. According to the results obtained, were established the optimal condition pickling at 20 g/l of ferric ions, 25 °C and p-toluensulphonic acid as stabilizer of H2O2. The HF pickling mixture was the only capable to remove totally the oxide layer from the 316L stainless steel after 300 s. The fluoride salts pickling mixtures only remove partially the oxide layer (20 to 40 % aprox. after 300 s. When the pickling time was increased until 1200 s, the removal percentages were around to 80 %.En este estudio se presenta el decapado del acero inoxidable austenítico 316L utilizando mezclas de peróxido de hidrógeno (H2O2/ácido sulfúrico (H2SO4/iones fluoruro; los iones fluoruro provienen del ácido fluorhídrico (HF, fluoruro de sodio (NaF y fluoruro de potasio (KF. La estabilidad del H2O2 fue valorada modificando las concentraciones del ión férrico de 0 a 40 g/l y las temperaturas de 25 °C a 60 °C en las mezclas decapantes. Se establecieron las condiciones óptimas de decapado utilizando 20 g/l de iones férrico a 25 °C empleando el ácido p-toluensulfónico como estabilizante del H2O2. La mezcla que contenía HF fue la única capaz de eliminar completamente los óxidos superficiales del acero a tiempos de 300 s. Las mezclas a base de sales fluoradas eliminaron parcialmente los óxidos (20 y 40 % aprox. en 300 s. Al incrementar el tiempo de decapado hasta 1200 s se obtuvieron porcentajes de eliminación alrededor de un 80 %.

Evaluation of Military Field-Water Quality. Volume 2. Constituents of Military Concern from Natural and Anthropogenic Sources. Part 1. Organic Chemical Contaminants

Science.gov (United States)

1988-01-01

2, Pt. 1 20. Cordero, A., B. Chacon, and A. Rodriguez, " Contaminacion del Rio Bermudez, Alajuela," Anron. CostaLT. 3, 109-113 (1979). 21. Krasner, S...34.................................. 0EXACHLO E-A 0 R 0H - V ? YLCHLORIDE . I t o RO-0 ORO - 7 L.CHLO +R@- L: TRACNLORO ,DICHLORO- 15 4 AC: PI ETAI C Ro- .1 IT; RJIBR ffi"PR...4*6-T CHL ORO ,1 00 N a MINIMUM 14 1 0 CAV RallCA D I7 H AE NTADIENER EXACHLORAT 0C C A4 C t 1 THEDJAIII f. .wc R,.oo.1 7I .a . ,. OCLORG- 0 0 0 I

Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure

Science.gov (United States)

2009-07-01

p ro toco ls were discussed w i t h t h i s guidance i n mind. The IRB reviewed these s p e c i f i c areas o f performance f o r each p ro... toco l be ing reviewed, w i t h d iscuss ion o f any concerns o r poss ib l e discrepancies: v e r i f i c a t i o n o f t h e names and...The f o l l o w i n g p ro toco l which has been approved f o r Cont inuing Review i s requ i red t o submit t h e next Cont inuing Review i

Hydrazinium(1+) hexafluorotitanate(IV), 2N2H5+.TiF62-

International Nuclear Information System (INIS)

Leban, I.

1994-01-01

The crystals exhibit racemic twinning. The structure consists of hydrazinium(1+), N 2 H 5 + , cations and usual octahedral hexafluorotitanate(IV) anions. They are linked together via hydrogen bonds of the types N-H..F and N-H..N. (orig.)

Pharmacokinetics and N-acetylation metabolism of S-methyl-l-cysteine and trans-S-1-propenyl-l-cysteine in rats and dogs.

Science.gov (United States)

Amano, Hirotaka; Kazamori, Daichi; Itoh, Kenji

2016-11-01

1. Pharmacokinetics and N-acetylation metabolism of S-methyl-L-cysteine (SMC) and trans-S-1-propenyl-L-cysteine (S1PC) were examined in rats and dogs. SMC and S1PC (2-5 mg/kg) were well absorbed in both species with high bioavailability (88-100%). 2. SMC and S1PC were excreted only to a small extent in the urine of rats and dogs. The small renal clearance values (l/h/kg) indicated the extensive renal reabsorption of SMC and S1PC, which potentially contributed to their long elimination half-lives (>5 h) in dogs. 3. S1PC, but not SMC, underwent N-acetylation extensively in vivo, which can be explained by the relative activities of N-acetylation of S1PC/SMC and deacetylation of their N-acetylated forms, N-acetyl-S1PC/N-acetyl-SMC, in the liver and kidney in vitro. The activities for S1PC N-acetylation were similar to or higher than those for N-acetyl-S1PC deacetylation in liver S9 fractions of rat and dog, whereas liver and kidney S9 fractions of rat and dog had little activity for SMC N-acetylation or considerably higher activities for N-acetyl-SMC deacetylation. 4. Our study demonstrated that the pharmacokinetics of SMC and S1PC in rats and dogs was characterized by high bioavailability and extensive renal reabsorption; however, the extent of undergoing the N-acetylation metabolism was extremely different between SMC and S1PC.

Ortaokul 5. ve 6. Sınıf Fen Bilimleri Öğretim Programının Kazanım ve İçerik İlişkisinin Değerlendirilmesi

OpenAIRE

Ocak, Gürbüz; Kutlu Kalender, M. Damla

2018-01-01

Bu çalışma Milli Eğitim Bakanlığı tarafından basılmış 5. ve 6. Sınıf Fen Bilimleri ders kitaplarındaki içeriğin, ortaokul 5. ve 6. Sınıf Fen Bilimleri dersi öğretim programındaki kazanımlara uygunluk düzeyini değerlendirmeyi amaçlamıştır. Öncelikle 2015-2016 eğitim öğretim yılı 5. ve 6.sınıf öğretim programındaki kazanımlarla 5.ve 6. sınıf fen bilimleri ders kitaplarındaki içerikler incelenmiştir. Değerlendirme için ölçme aracı olarak kazanım-içerik değerlendirme rubriği hazırlanmıştır. Geliş...

Further contribution to the diatom flora of sewage enriched waters in southern Africa

CSIR Research Space (South Africa)

Schoeman, FR

1972-01-01

Full Text Available PHYCOLOGI A 11(3/4 ) 1972 . A furthe r contributio n t o th e diato m flor a o f sewag e enriche d water s i n souther n Afric a F . R . ScH0EMA N Counci l fo r Scientifi c an d industria l Research , Nationa l institut e fo r Wate r Research , Pretoria... , Republi c o f Sout h Afric a Accepte d Jun e 12 , 197 2 Th e systematic s an d autecolog y o f th e diatom s observe d i n a n alga l sampl e fro m a maturatio n pon d o f th e Walvi s Ba y (Sout h Wes t Africa n coast ) sewag e work s ar e discussed...

Choc hémorragique suite à une ponction biopsie rénale (PBR): à propos d'un cas

Science.gov (United States)

El Hammoumi, Jalal; Boukatta, Brahim; Houari, Nawfal; Elbouazzaoui, Abderrahim; Sbai, Hicham; Kanjaa, Nabil

2015-01-01

La ponction biopsie rénale (PBR) est un examen indispensable en néphrologie mais à risque de complications graves surtout hémorragique. Nous rapportons l'observation d'un patient âgé de 27 ans ayant bénéficié d'une PBR pour un diagnostic étiologique d'une insuffisance rénale aigue, l’évolution après la biopsie a été marquée par l'installation d'un choc hémorragique d'où la prise en charge en réanimation avec une néphrectomie d'hémostase. PMID:26848362

Från outsiderfilmmakare till etablerad indieregissör : David Lynch, Jim Jarmusch och Steven Soderbergh

OpenAIRE

Simberg, Maximilian

2014-01-01

Det här arbetet behandlar kreativ frihet och konstnärligt oberoende i filmskapande, utgående från begreppet independent film och regissörerna David Lynch, Jim Jarmusch och Steven Soderbergh. Den centrala frågeställningen är hur det har varit möjligt för en filmkonstnär att uppnå konstnärligt oberoende och samtidigt ha en långlivad och framgångsrik karriär. Arbetets fokus ligger på de tre regissörernas genombrottsfilmer; Eraserhead, Stranger Than Paradise och sex, lies, and videotape, och förs...

Gestion de l'eau — Des collectivités relèvent le défi de fournir de l ...

International Development Research Centre (IDRC) Digital Library (Canada)

2 févr. 2011 ... Ces recherches montrent clairement, en outre, que l'accès à l'eau de ... Zusammenarbeit (l'agence de coopération technique allemande) et de .... un accord : aucun détournement n'aurait lieu sans travaux scientifiques à l'appui. ... prometteur pour le règlement des différends internationaux relatifs à l'eau.

Implications of extreme flatness in a general f(R theory

Directory of Open Access Journals (Sweden)

Michał Artymowski

2016-09-01

Full Text Available We discuss a modified gravity theory defined by f(R=∑nlαnM2(1−nRn. We consider both finite and infinite number of terms in the series while requiring that the Einstein frame potential of the theory has a flat area around any of its stationary points. We show that the requirement of maximally flat stationary point leads to the existence of the saddle point (local maximum for even (odd l. In both cases for l→∞ one obtains the Starobinsky model with small, exponentially suppressed corrections. Besides the GR minimum the Einstein frame potential has an anti de Sitter vacuum. However we argue that the GR vacuum is absolutely stable and AdS can be reached neither via classical evolution nor via quantum tunnelling. Our results show that a Starobinsky-like model is the only possible realisation of f(R theory with an extremely flat area in the Einstein frame potential.

The Function of Bazaar in the Modern World

Directory of Open Access Journals (Sweden)

Mustafa HİZMETLİ

2014-12-01

Full Text Available One of the topics in Islam which has not been studied d e e p l y and which has started to attract attention lately is bazaars. T h e r e f o r e , i n t h i s r e s e a r c h f ollowing a short information on the development of bazaars in Muslim world, moving from the solidarity and cooperation roles of the sellers in bazaars in Baghdad, the capital city of Abbasids and the cooperation of the sellers in bazaars during the Iran Islam revolution , inferences were made on what kind of roles bazaars could play in the modern world . T h i s r e s e a r c h i n t e n d s t o d e p i c t t h e i m p o r t a n c e o f t h e b a z a a r o n t h e s o c i a l i n t e g r i t y a n d p r o f e s s i o n a l s o l i d a r i t y a m o n g t r a d e s m e n d u r i n g e a r l y Islamic t i m e s .

Evaluación físico-química y microbiológica de la calidad del agua de los ríos Machángara y Monjas de la red hídrica del distrito metropolitano de Quito

Directory of Open Access Journals (Sweden)

Andrea Campaña

2017-05-01

Full Text Available El presente estudio es una evaluación de la calidad y condición actual del agua de los ríos Machángara y Monjas, se midió parámetros físico-químicos como caudal, pH, temperatura, oxígeno disuelto y Potencial de Óxido Reducción (ORP mediante monitoreo in situ, durante los meses de agosto a noviembre del 2014, y se recolectó muestras de agua para el análisis de parámetros microbiológicos (coliformes totales CT y coliformes fecales CF, aplicando el método de fermentación de tubos múltiples, establecido en el Estándar Métodos (Standard Methods ; los análisis evidenciaron que ambos ríos superan ampliamente los límites permisibles establecidos en el Texto Unificado de Legislación Secundaria Medio Ambiental (TULSMA para coliformes totales y fecales, temperatura y oxígeno disuelto, en el caso del río Monjas; esto impediría su aprovechamiento en actividades pecuarias, agrícolas y de preservación de flora y fauna, se evidenció además un incremento considerable en el caudal de ambos ríos y se observa que el valor de ORP de ambos ríos, es menor al valor óptimo de 650mV; los resultados confirmaron la deficiente calidad del agua de los ríos estudiados, cuyas subcuencas forman parte de la Red Hídrica del Distrito Metropolitano de Quito (DMQ y atraviesan zonas de gran densidad poblacional, recibiendo diariamente descargas domésticas e industriales.

Sker der noget med læringdudbyttet, når undervisningssproget skiftes?

Directory of Open Access Journals (Sweden)

Camilla Falk Rønne Nissen

2016-04-01

Full Text Available I takt med en øget internationalisering af de videregående uddannelser øges mængden af undervisning på engelsk på de danske universiteter. Men hvilke konsekvenser har det for kvaliteten af undervisningen? Falder læringsudbyttet, når der undervises på et sprog, der for de fleste universitetsstuderende og undervisere ikke er deres førstesprog? Denne artikel prøver gennem et litteraturreview at finde svar i den eksisterende, forskningsbaserede litteratur. Første del af reviewet identificerer interesseområder i forskningen, mens anden del gennemgår resultater fra enkelte studier med fokus på læring og deltagelse, særligt i en nordisk kontekst. The internationalization of higher education has driven Danish universities to increase the amount of teaching in English. But what are the consequences for the quality of the education? Is the quality of the learning outcome compromised when teaching and learning activities take place in a second language? Based on a literature review of existing, research-based literature, this article tries to offer some answers to that question. The first part of the review identifies different research interests, while the second part of the review discusses results from selected studies that have focused on student learning and activity, especially within a Nordic setting.

DFT Calculation of IR Absorption Spectra for PCE-nH2O, TCE-nH2O, DCE-nH2O, VC-nH2O for Small and Water-Dominated Molecular Clusters

Science.gov (United States)

2017-10-31

VC-nH2O for Small and Water-Dominated Molecular Clusters October 31, 2017 Approved for public release; distribution is unlimited. L. Huang S.g...Calculation of IR Absorption Spectra for PCE-nH2O, TCE-nH2O, DCE-nH2O, VC-nH2O for Small and Water-Dominated Molecular Clusters L. Huang,1 S.G...nH2O molecular clusters using density function theory (DFT). DFT can provide interpretation of absorption spectra with respect to molecular

Konflikter, ogräs eller frön? : Arbetsplatskonflikter utifrån ett ledarskapsperspektiv

OpenAIRE

Aarvaag, Evalinda; Lindroth, Linda

2016-01-01

Det gemensamma intresset för konflikter grundade idén att studera väl ansedda ledares perspektiv på arbetsplatskonflikter och hur dessa ledare löser konflikter konstruktivt. I grunden finns en undran om väl ansedda ledare har förmågor som gör att de löser konflikter mer konstruktivt. Konflikter utgör en stor del av en ledares arbetstid. Konflikter kan förmodligen inte undvikas men hur konflikter hanteras är avgörande för att en organisation och dess anställda skall mogna och utvecklas. Det ha...

Sistema de información WEB para la administración del recurso hídrico superficial de la cuenca del río La Vieja, en Colombia

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Jenny Carolina Ramírez-Leal

2014-01-01

Full Text Available Este trabajo presenta el desarrollo de una herramienta Web georreferenciada a través de la API de Google Maps, para administrar los recursos hídricos superficiales de la cuenca del río La Vieja en Colombia. Esto con el fin de crear un sistema de integración de información de fácil acceso, que ofrezca a las personas datos reales y actuales acerca del estado de los recursos hídricos en la cuenca del río La Vieja, para futuras consultas e investigaciones. Esta aplicación Web se llevó a cabo a través de la metodología ágil SCRUM y la metodología Mpiua, que integradas permitieron un desarrollo evolutivo e incremental, donde se involucró al usuario activamente al momento de incorporar aspectos de usabilidad y accesibilidad. Así mismo, se hizo uso de la arquitectura MVC para obtener un producto más escalable con abstracción de datos, código entendible, intercomunicación entre componentes y control de los recursos del servidor. Finalmente, se obtuvo la implementación de la herramienta Web HidroQuindío, que permite administrar la información de las estaciones de monitoreo, fuentes hídricas, entes territoriales, fuentes de captación y estructuras de conducción de apoyo a la toma de decisiones alrededor de la cuenca.

meso-4,4′-Difluoro-2,2′-{[(3aR,7aS-2,3,3a,4,5,6,7,7a-octahydro-1H-1,3-benzimidazole-1,3-diyl]bis(methylene}diphenol

Directory of Open Access Journals (Sweden)

Augusto Rivera

2013-02-01

Full Text Available In the crystal structure of the title compound, C21H24F2N2O2, there are two intramolecular O—H...N hydrogen bonds involving the N atoms of the imidazolidine ring and the hydroxy groups. The crystal studied was a meso compound obtained by the reaction of the aminal (2S,7R,11S,16R-1,8,10,17-tetraazapentacyclo[8.8.1.18,17.02,7.011,16]cosane with 4-fluorophenol. The imidazolidine ring has a twisted conformation with a CH—CH—N—CH2 torsion angle of 44.99 (14° and, surprisingly, the lone pairs of the N atoms are disposed in a syn isomerism, making the title compound an exception to the typical `rabbit-ear effect' in 1,2-diamines. In the crystal, molecules are linked via C—H...F hydrogen bonds, forming chains along the c-axis direction. These chains are linked via another C—H...F hydrogen bond, forming a three-dimensional network.

Riskuppfattningar om preventivmedel för män och kvinnor : altruism, riskbenägenhet och traditionella könsroller

OpenAIRE

Nilsson Gauffin, Rebecka

2017-01-01

Preventivmedel för kvinnor innefattar en betydande andel biverkningar. Hittills har män inte upplevt några allvarliga biverkningar av de testade preventivmedlen för män, trots detta är det biverkningarna som stoppat preventivmedel för män från att lanseras på marknaden. I denna studie argumenteras för att en möjlig förklaring till detta ligger i skilda riskuppfattningar om preventivmedel för män och kvinnor. Studien undersöker riskuppfattningar om preventivmedel samt hur individers egenskaper...

Cyberskepticism: The Mind’s Firewall

Science.gov (United States)

2008-01-01

some of the worst cases, have resulted in suicides, identity theft, financial scandals, assists to pedophiles , and “cybercide” (inadvertently...one of the most common ways for law enforcement personnel to catch pedophiles . N i c h o l a s C a r r , f o r m e r executive editor of the

Disentangling the f(R)-duality

Energy Technology Data Exchange (ETDEWEB)

Broy, Benedict J.; Westphal, Alexander [Deutsches Elektronen-Synchrotron DESY, Theory Group, Hamburg, 22603 Germany (Germany); Pedro, Francisco G., E-mail: benedict.broy@desy.de, E-mail: francisco.pedro@desy.de, E-mail: alexander.westphal@desy.de [Departamento de Física Teórica and Instituto de Física Teórica UAM-CSIC, Universidad Autónoma de Madrid, Cantoblanco, Madrid, 28049 Spain (Spain)

2015-03-01

Motivated by UV realisations of Starobinsky-like inflation models, we study generic exponential plateau-like potentials to understand whether an exact f(R)-formulation may still be obtained when the asymptotic shift-symmetry of the potential is broken for larger field values. Potentials which break the shift symmetry with rising exponentials at large field values only allow for corresponding f(R)-descriptions with a leading order term R{sup n} with 1<n<2, regardless of whether the duality is exact or approximate. The R{sup 2}-term survives as part of a series expansion of the function f(R) and thus cannot maintain a plateau for all field values. We further find a lean and instructive way to obtain a function f(R) describing m{sup 2}φ{sup 2}-inflation which breaks the shift symmetry with a monomial, and corresponds to effectively logarithmic corrections to an R+R{sup 2} model. These examples emphasise that higher order terms in f(R)-theory may not be neglected if they are present at all. Additionally, we relate the function f(R) corresponding to chaotic inflation to a more general Jordan frame set-up. In addition, we consider f(R)-duals of two given UV examples, both from supergravity and string theory. Finally, we outline the CMB phenomenology of these models which show effects of power suppression at low-ℓ.

Disentangling the f(R)-duality

Energy Technology Data Exchange (ETDEWEB)

Broy, Benedict J. [Deutsches Elektronen-Synchrotron DESY, Theory Group, Hamburg, 22603 (Germany); Pedro, Francisco G. [Departamento de Física Teórica and Instituto de Física Teórica UAM-CSIC, Universidad Autónoma de Madrid, Cantoblanco, Madrid, 28049 (Spain); Westphal, Alexander [Deutsches Elektronen-Synchrotron DESY, Theory Group, Hamburg, 22603 (Germany)

2015-03-16

Motivated by UV realisations of Starobinsky-like inflation models, we study generic exponential plateau-like potentials to understand whether an exact f(R)-formulation may still be obtained when the asymptotic shift-symmetry of the potential is broken for larger field values. Potentials which break the shift symmetry with rising exponentials at large field values only allow for corresponding f(R)-descriptions with a leading order term R{sup n} with 1<n<2, regardless of whether the duality is exact or approximate. The R{sup 2}-term survives as part of a series expansion of the function f(R) and thus cannot maintain a plateau for all field values. We further find a lean and instructive way to obtain a function f(R) describing m{sup 2}ϕ{sup 2}-inflation which breaks the shift symmetry with a monomial, and corresponds to effectively logarithmic corrections to an R+R{sup 2} model. These examples emphasise that higher order terms in f(R)-theory may not be neglected if they are present at all. Additionally, we relate the function f(R) corresponding to chaotic inflation to a more general Jordan frame set-up. In addition, we consider f(R)-duals of two given UV examples, both from supergravity and string theory. Finally, we outline the CMB phenomenology of these models which show effects of power suppression at low-ℓ.

Hickam AFB, Hawaii Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

Science.gov (United States)

1985-04-01

ZkAN~,I EATV A. TO RELATIVE HUMIDITY -- EAT’E~SE; VIC /MAL I.I 2n 4CK A A F H---- 74-337 STATION STATION NAME PERIOD CUMULATIVE PERCENTAGE FREQUENCY...AL 1 li 9 o G l O 1 0 . 1; 99 .9 7 92 -6 71.2 4 1’_.1 l S 1 67 . 72 2- ] USAFETAC F 0.87-5 (OL A) ....... -LCAIAL CL!’"ATCL3Y -sRANCM EATV - c L r TAC

Indian Mountain AFS, Alaska. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

Science.gov (United States)

1983-06-01

tT A: CSURFACE WINDS AlY .EAT" 1, SEPV;C’./- kC PERCENTAGE FREQUENCY OF WIND DIRECTION AND SPEED (FROM HOURLY OBSERVATIONS) V ? -> \\l A ~i’, T A I N A...1 0 21 -22 23 24 25 2627 28 29.30 31 , o, . - - FE-r.Z X No. Obs. Mo. No. of No-.. -%8 Teo ,at-rv. R&H-. F 32 F 67 F *73 F *80 F *93 F To D,v B-b S

Facteurs prédictifs de la réponse à la CERA chez les hémodialysés ...

African Journals Online (AJOL)

Facteurs prédictifs de la réponse à la CERA chez les hémodialysés chroniques naïfs de traitement par agent stimulant l'érythropoïèse. ... Il s'agit une étude prospective mono centrique faite au sein d'une population d' hémodialysés chroniques. ... L'anémie est une complication majeure chez les hémodialysés chroniques.

Farmacocinética comparada de metformina, en forma sólida y en formulación extemporánea líquida para pediatría, en voluntarios adultos sanos

Directory of Open Access Journals (Sweden)

L Rivera-Espinosa

2016-06-01

Full Text Available ANTECEDENTES: fraccionar o pulverizar tabletas de metformina para ajustar dosis pediátricas dificulta su administración, genera inestabilidad del fármaco (oxidación/fotosensibilidad y relativiza su biodisponibilidad. Se propone como alternativa de ajuste de dosis y de uniformidad de contenido una formulación extemporánea líquida a partir de tabletas de marca comercial. OBJETIVO: determinar la biodisponibilidad de metformina en formulación líquida, en voluntarios adultos sanos, para demostrar que su comportamiento farmacocinético permanece inalterado. MATERIALES Y MÉTODOS: estudio clínico, aleatorio, cruzado y longitudinal, en adultos sanos voluntarios (n=12, 7 varones y 5 mujeres, de 24.3 ± 1.8 años, con índice de masa corporal = 24.9 ± 2.5 kg/m2. Se obtuvieron muestras sanguíneas en gotas, colectadas en tarjetas Whatman 903®, a las 0.25, 0.5, 1, 2, 4, 8 y 12 horas de ingerir 250 mg del fármaco. Se extrajo el fármaco a partir de 5 discos de papel filtro con sangre impregnada (16 μL, por precipitación directa, con acetonitrilo (ACN y metanol.  La detección fue en una columna AcQuity UPLC BEH HILIC (2.1 × 100mm, 1.7 μm por espectrometría de masas en tándem. Fase móvil: acetato de amonio 5 mM y ACN (80:20; v/v, a 0.25 mL/min isocráticamente. La farmacocinética se determinó mediante el programa Win Nonlin Pro 3.1 y las diferencias se evaluaron por ANOVA de una vía (p ≤ 0.05. RESULTADOS: el método fue exacto, preciso, selectivo y lineal entre 50 y 1000 ng/mL, coeficiente de determinación (r de 0.9982. Las muestras extraídas y almacenadas a 4°C fueron estables por 17 horas y hasta 2 meses a -80°C. La metformina en tableta tuvo una Cmáx de 553.4 ng/mL y de 692.2 ng/mL con la formulación líquida. El Tmáx fue menor con la solución edulcorada (1.6 h que con la tableta (1.8 h. La ke fue menor con la forma líquida (0.29 vs. 0.32 h-1, lo que sugiere que se eliminó más rápidamente. El AUC0-12 fue

S.A.G.A.R.A.: 'sistema de ayuda a la gestión del agua en la región de Antofagasta'

Directory of Open Access Journals (Sweden)

1998-01-01

Full Text Available SAGARA : SYSTEME D’AIDE A LA GESTION DE L’EAU DANS LA REGION D’ANTOFAGASTA. La complexité de l’information collectée dans le domaine des ressources hydriques de la région d’Antofagasta a conduit à la mise en place d’un Système d’Information Géographique. Ce système géré par un puissant logiciel, fournit à tous ceux qui se préoccupent de la gestion de l’eau dans cette zone particulièrement aride, et aux besoins toujours croissants, une base de données très complète et à la fois très facile à utiliser. Ce SIG a pour but d’offrir un appui technique et ainsi permettre la gestion rationnelle d’un capital en eau limité. La complejidad de la información colectada a propósito de los recursos hídricos en la región de Antofagasta condujo a la elaboración de un Sistema de Información Geográfica. Este sistema, trabajado en un potente software, proporciona a quienes se preocupan de la gestión del agua en esta zona extremadamente árida, y con demandas en constante aumento, una base de datos muy completa y a la vez muy fácil de manejar. Este SIG pretende apoyar técnicamente una gestión racional del magro capital “agua”. SAGARA: MANAGEMENT WATER SUPPORT SYSTEM IN THE ANTOFAGASTA DISTRICT. The complexity of the information collected in the area of the hidrical resources in the Antofagasta district led to the settlement of a Geographical Information System. This highly powerful software managed system provides a very complete and easy-to-use database to who involved with all water management matters in such arid and constantly increasing requirements zone. GIS is aimed at providing a technical support so as to allow a more rational management of the scarce water capital.

Chironomus plumosus' påvirkning af næringsstofflukse i restaurerede søer

DEFF Research Database (Denmark)

Kristensen, T. B.; Reitzel, K.; Andersen, F. Ø.

Den interne næringsstofbelastning af en række danske søer har betydet at disse søer er forblevet i en uklar, algedomineret tilstand til trods for reduktioner i mængden af tilførte næringsstoffer. I mange tilfælde er der derfor efterfølgende lavet et eller flere restaureringsindgreb for at skabe e....... plumosus efter længere tid vil øge bindingen af fosfor.   Andersen,F.Ø.; Jørgensen,M.; Jensen, H.S. (2006). The influence of Chironomus plumosus larvae on nutrient fluxes and phosphorus fractions in aluminum treated lake sediment. Water, Air, and Soil Pollution: Focus....

Rubinstein S. L., Osnovy obshchei psikhologii (Les fondements de la psychologie générale. Professionnalisation et développement professionnel

Directory of Open Access Journals (Sweden)

Ludmila Namolovan-Stephan

2011-06-01

Full Text Available L’ouvrage classique en langue russe « Les fondements de la psychologie générale » de S.L. Rubinstein appartient aux œuvres les plus reconnues de la psychologie russe. L’étendue des généralisations théoriques, l’envergure encyclopédique du matériel historique et expérimental, la clarté des principes méthodologiques exposés ont fait de cet ouvrage une référence pour plusieurs générations de psychologues, pédagogues et philosophes.Cet ouvrage présente trois intérêts majeurs :D’abord, il intègre ...

Brotación in vitro de yemas de teca (Tectona grandis L. f. Sprouting buds in vitro teak (Tectona grandis L. f.

Directory of Open Access Journals (Sweden)

Fabiana Rojas Parajeles

2012-11-01

Full Text Available La teca (Tectona grandis L.f. es una especie maderable exótica introducida a Costa Rica para la siembra de plantaciones comercial por la alta demanda de su madera, su rápido crecimiento y su alta calidad. Inicialmente se utilizó la semilla como único material de siembra y la pobre calidad de muchas de las plantaciones impulsó el inicio de programas de mejora genética. La propagación clonal tomó mucha importancia en estos programas y el cultivo in vitro se convirtió en una herramienta valiosa para la propagación masiva de los árboles élites. Por lo anterior, este trabajo se enfocó en evaluar el efecto de varias concentraciones de dos reguladores de crecimiento, bencilaminopurina (BA y ácido indolacético (AIB, solos y en combinación, en la brotación de yemas dormantes y formación de callos de teca. Tanto el análisis estadístico como la observación visual mostraron que el tratamiento que consistió de 0,005 mg/l de AIA fue el mejor para incrementar la brotación de las yemas y para disminuir la formación de callo.Teak (Tectona grandis L. f. is an exotic timber species introduced to Costa Rica for commercial plantations due to the high demand for its wood, rapid growth and high-quality. Initially the seed was use as the only planting material, but the poor quality of many of the plantations resulted in the initiation of genetic improvement programs. The introduction of clonal propagation in these programs and the establishment of in vitro culture techniques became import tools for mass propagation of the selected elite trees. On the foregoing, this work focused on assessing the effect of several concentrations of two growth regulators, benzylaminopurine (BA and indole acetic acid (AIB, alone and in combination, in the budding of dormantes buds and callus formation of teak. Both the statistical analysis and the visual observation showed that the treatment consisted of 0.005 mg/l of IAA was the best to increase the budding of the

Evaluation of a solid phase R.I.A. technique and solid phase E.L.I.S.A. technique for the demonstration of hepatitis B surface antigen

International Nuclear Information System (INIS)

Vranckx, R.; Cole, J.; Peetermans, M.

1977-01-01

We compared the sensitivity of a solidphase radio-immunoassay (R.I.A.), a solid-phase enzyme-immunoassay (E.L.I.S.A.) and a hemagglutination test (R.P.H.A.) for the detection of the HBs Ag in two ways: 1) by screening a panel of 300 sera (97 positives and 203 negatives) 2) by titrating serial dilutions of 10 positive sera. Ninety seven sera were positive by R.I.A., 95% were detected by E.L.I.S.A. and 81% were detected by R.P.H.A. In the serial dilutions the average end points of the titration were for R.I.A. 0.005 ng/ml, for E.L.I.S.A. 0,01 ng/ml and for R.P.H.A. 0.04 ng/ml. It can be concluded that the sensitivity of the E.L.I.S.A. test is intermediate between the sensitivity of the R.I.A. and the sensitivity of the R.P.H.A. The E.L.I.S.A. and the R.P.H.A. tests seam to be a little more sensitive for the detection of subtype ay than the detection of subtype ad. (orig.) [de

High Power Microwave Tube Reliability Study

Science.gov (United States)

1976-08-01

Minimum Gain Check 123 Poor Spectrum 124 Low Anode Current 125 Failed Noise Figure Check 126 Cathode Depletion 127 Gassy/Loss of Vacuum 130 Cathode ...FAILURES Oil System Failures 210 Punctured Cathode Bushing 213 Pulse Transformer Failures 215 Punctured Heater Seal 235 Window Arcing 241 Multipactoring...UO -4.4 * l r- -.T r- 𔃺 𔃺 𔃺 𔃺 In Hd 0 UU 𔃺𔃺 H CA Ho <t 03H E-4~ ~ wI. 0A CA LA 𔃺 Co3 E- co 04 H 01) Co Ln N’ O 𔃾 N’ to r- In LA Co nCA .- (f

Tolerance mechanisms in mercury-exposed Chromolaena odorata (l.f. R.M. King et H. Robinson, a potential phytoremediator

Directory of Open Access Journals (Sweden)

H J P Alcantara

2013-10-01

Full Text Available Chromolaena odorata (L.f. R.M. King et H. Robinson plants were grown in Hoagland’s solutions with 0.00 ppm and 1.00 ppm Hg(NO32. The calcium, magnesium, iron, and sulfur levels in the leaves were found to be not significantly affected by presence of the uptaken Hg2+. The chlorophyll a, chlorophyll b, and total chlorophyll contents of its leaves also remained within normal levels, which may indicate that the photosynthetic machinery of the Hg-exposed C. odorata was unaffected by the presence of Hg2+. The results of the ICP-AES analyses of the Hg2+ contents established the presence of Hg2+ in all the subcellular components obtained from the leaves of the Hg-treated C. odorata plants, and that the ultimate localization of Hg2+ is in the vacuoles. The findings revealed no significant differences in the degree of oxidative injury between the cells from the control and Hg-treated plants, as evidenced by the low lipid peroxidation levels obtained with the TBARS assay. The SH-containing biomolecules that were initially detected through DTNB assay manifested a predominant peak in the RP-HPLC chromatographs of both the control and Hg-treated plants, with their retention times falling within the ranges of GSH, MT, and cysteine standards. However, the concentrations of the GSH- and/or MT-like, Cys-containing biomolecules detected in the leaves of Hg-treated C. odorata plants were ten times higher than those of the control.The findings of this study suggest that the enhanced antioxidative capacity, the production of Hg-binding biomolecules, and the localization of Hg2+ ions ultimately in the vacuoles of the leaves are the mechanisms which bring about Hg2+ tolerance and homeostasis in C. odorata plant. These results indicate that C. odorata is a potentially effective phytoremediator for Hg2+.

Tolerance mechanisms in mercury-exposed Chromolaena odorata (l.f. R.M. King et H. Robinson, a potential phytoremediator

Directory of Open Access Journals (Sweden)

H.J.P. Alcantara

2013-10-01

Full Text Available Chromolaena odorata (L.f. R.M. King et H. Robinson plants were grown in Hoagland’s solutions with 0.00 ppm and 1.00 ppm Hg(NO32. The calcium, magnesium, iron, and sulfur levels in the leaves were found to be not significantly affected by presence of the uptaken Hg2+. The chlorophyll a, chlorophyll b, and total chlorophyll contents of its leaves also remained within normal levels, which may indicate that the photosynthetic machinery of the Hg-exposed C. odorata was unaffected by the presence of Hg2+. The results of the ICP-AES analyses of the Hg2+ contents established the presence of Hg2+ in all the subcellular components obtained from the leaves of the Hg-treated C. odorata plants, and that the ultimate localization of Hg2+ is in the vacuoles. The findings revealed no significant differences in the degree of oxidative injury between the cells from the control and Hg-treated plants, as evidenced by the low lipid peroxidation levels obtained with the TBARS assay. The SH-containing biomolecules that were initially detected through DTNB assay manifested a predominant peak in the RP-HPLC chromatographs of both the control and Hg-treated plants, with their retention times falling within the ranges of GSH, MT, and cysteine standards. However, the concentrations of the GSH- and/or MT-like, Cys-containing biomolecules detected in the leaves of Hg-treated C. odorata plants were ten times higher than those of the control. The findings of this study suggest that the enhanced antioxidative capacity, the production of Hg-binding biomolecules, and the localization of Hg2+ ions ultimately in the vacuoles of the leaves are the mechanisms which bring about Hg2+ tolerance and homeostasis in C. odorata plant. These results indicate that C. odorata is a potentially effective phytoremediator for Hg2+.

N R Munirathnam

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. N R Munirathnam. Articles written in Bulletin of Materials Science. Volume 25 Issue 2 April 2002 pp 79-83 Materials Synthesis. Preparation of high purity tellurium by zone refining · N R Munirathnam D S Prasad Ch Sudheer A J Singh T L Prakash · More Details Abstract Fulltext ...

Optimering av nanocellulosa för tillämpning som papperstyrkeadditiv

OpenAIRE

Englöf, Johan

2015-01-01

Syftet med projektet var att undersöka hur homogeniserings förhållanden (tryck antal passager och därmed energiinsatsen) vid framställning av MFC (mikrofibrillär cellulosa), från enzymatiskt förbehandlade pappersmassafibrer påverkar hållfastheten av papper förstärkt med MFC. Arbetsgivaren för projektet var Innventia och det laborativa arbetet har utförts i deras lokaler. Fördelen med att använda MFC som tillsats i papper är att arket blir starkare [1]. Detta medför att en mindre mängd materia...

Tryckerimomsmålen : En utredning av de skatterättsliga och civilrättsliga konsekvenserna ur rättssäkerhetsperspektiv

OpenAIRE

Haglund, Emma; Olsson, Anna

2015-01-01

2010 lämnade EU-domstolen ett förhandsavgörande i mål C-88/09 Graphic Procédé gällande huruvida vissa tryckeriprodukter ska anses utgöra varor eller tjänster enligt EU:s mervärdesskattedirektiv. Domen innebar för svensk lagstiftning att mervärdesskattesatsen för vissa tryckeriprodukter sänktes från 25 procent till 6 procent. Konsekvensen blev att skatteverket fick återbetala miljonbelopp till svenska tryckerier på grund av att de redovisat för hög mervärdesskatt. Skatteverket godtog återbetal...

Sağlık ve Beslenme Açısından Sebzelerin Önemi

Directory of Open Access Journals (Sweden)

Atilla Eriş

2015-02-01

çarlar, e Sindirimi kolaylaştırırlar, f Hayvansal besin maddeleri ile oluşan asit fazlalığını nötralize ederler, g Terapetik fonksiyonları vardır. Sebzelerin insan sağlığı yönünden bir önemi de, bazı hastalıklara karşı kullanılmalarıdır. Örneğin, sarımsak’ın, damar sertliğine, kalp hastalıklarına v.s. siyah turp’un taş düşürmeye, ses kısıklığına v.s.; pırasa’nın öksürük, sinir hastalıklarına v.s. kullanıldığı görülmektedir. İlaç olarak kullanılabilen sebzelerin sayısı daha çok arttırılabilir. Bunun dışında bazı sebzelerden kozmetik sanayiinde de yararlanılmaktadır. Bütün yıl boyunca çeşitli sebzelerden yararlanabilmek için bunların taze tüketiminin yanında; aşağıda belirtildiği gibi değişik şekillerdeki değerlendirmeleri de yapılmaktadır. a Taze b Konserve c Dondurulmuş sebzeler d Salça e Sebze suları f Sebze tuzları g Turşular h Reçeller ı Kurutulmuş sebzeler

Experimental infection of clade 1.1.2 (H5N1), clade 2.3.2.1c (H5N1) and clade 2.3.4.4 (H5N6) highly pathogenic avian influenza viruses in dogs.

Science.gov (United States)

Lyoo, K S; Na, W; Phan, L V; Yoon, S W; Yeom, M; Song, D; Jeong, D G

2017-12-01

Since the emergence of highly pathogenic avian influenza (HPAI) H5N1 in Asia, the haemagglutinin (HA) gene of this virus lineage has continued to evolve in avian populations, and H5N1 lineage viruses now circulate concurrently worldwide. Dogs may act as an intermediate host, increasing the potential for zoonotic transmission of influenza viruses. Virus transmission and pathologic changes in HPAI clade 1.1.2 (H5N1)-, 2.3.2.1c (H5N1)- and 2.3.4.4 (H5N6)-infected dogs were investigated. Mild respiratory signs and antibody response were shown in dogs intranasally infected with the viruses. Lung histopathology showed lesions that were associated with moderate interstitial pneumonia in the infected dogs. In this study, HPAI H5N6 virus replication in dogs was demonstrated for the first time. Dogs have been suspected as a "mixing vessel" for reassortments between avian and human influenza viruses to occur. The replication of these three subtypes of the H5 lineage of HPAI viruses in dogs suggests that dogs could serve as intermediate hosts for avian-human influenza virus reassortment if they are also co-infected with human influenza viruses. © 2017 Blackwell Verlag GmbH.

Ada (Trade Name) Training Curriculum. Basic Ada Programming L202 Teacher’s Guide. Volume 1.

Science.gov (United States)

1986-01-01

4 . (A) 0 0 U)n c ~zz 0 L Iw m 0 0 W 0 4) 4 () cc 0 V) >- Z o - E z I x -j 0 C. m =zW ccZ- " I- 0 0z o ) aCCa - - z 0 N I--* S a-. ax a- c w Sn% L) C...oo U) 0 cc c C..) f8 4 (A U3 0 )0 C 1-- 00. _ zw w Ca41 LI (A) x Ř) cc (A w I- %__ _ 414 AjC CL W 0 64fl4 6-410 0 0h cr. U m L 0 a. 646)* w C.41 C w...Enl 0 wL U) W I cr. 0 w IL w 0 z L) w 0 u W F8 ~- - IL W >) " cr.0 0 Z x () U) IL W Z 0 U) - wi 0 4c 1 IL Un C 0 r C, wi 0 Z W w. w Ww i CL 00 03- z

Characterization of acid flux in osteoclasts from patients harboring a G215R mutation in ClC-7

DEFF Research Database (Denmark)

Henriksen, Kim; Gram, Jeppe; Neutzsky-Wulff, Anita Vibsig

2008-01-01

-I, calcium release, and pit area when comparing to age and sex matched controls. In addition, the ADOII osteoclasts showed no differences in actin ring formation. Finally, V-ATPase and chloride channel inhibitors completely abrogated the H(+) and Cl(-) driven acidification. Finally, the acid influx...... mutation in ClC-7 (G215R) were isolated, and used these to investigate bone resorption measured by CTX-I, calcium release and pit scoring. The actin cytoskeleton of the osteoclasts was also investigated. ClC-7 enriched membranes from the osteoclasts were isolated, and used to test acidification rates...... in the presence of a V-ATPase and a chloride channel inhibitor, using a H(+) and Cl(-) driven approach. Finally, acidification rates in ClC-7 enriched membranes from ADOII osteoclasts and their corresponding controls were compared. Resorption by the G215R osteoclasts was reduced by 60% when measured by both CTX...

AUTOMATISATION ET CONTROLE A DISTANCE DE L'INSTRUMENTATION DU LASER R.I.L.I.S. A ISOLDE

CERN Document Server

Chevallay, E

2003-01-01

A Isolde, les physiciens utilisent pour leurs expériences des isotopes rares produits par l'interaction d'un faisceau de protons provenant du synchrotron Booster et d'une cible métallique. Derrière cette cible, les isotopes qui sont produits et accélérés ne sont pas tous du même type et de la même masse. Des aimants de spectromètres (GPS ou HRS) sélectionnent les isotopes requis en fonction du rapport masse/charge. De plus, l'utilisation d'un laser de puissance pour ioniser les isotopes, le laser R.I.L.I.S. (Résonance Ionization Laser Ion Source), permet une bien meilleure sélectivité. Le système de lasers RILIS a été construit par la collaboration Isolde [1] en 1990. Son implication dans le programme de physique d'Isolde représente 50 % des expériences approuvées. Etant l'un des éléments clefs de la production d'isotopes rares à Isolde, il a bien entendu été intégré dans le programme de consolidation lancé en 2000 [2]. La consolidation du laser lui-même n'entre pas dans le cadre d...

Thermodynamic behavior of particular f(R,T)-gravity models

International Nuclear Information System (INIS)

Sharif, M.; Zubair, M.

2013-01-01

We investigate the thermodynamics at the apparent horizon of the FRW universe in f(R, T) theory in the nonequilibrium description. The laws of thermodynamics are discussed for two particular models of the f(R, T) theory. The first law of thermodynamics is expressed in the form of the Clausius relation T h dS-circumflex h = δ Q , where δQ is the energy flux across the horizon and dS-circumflex is the entropy production term. Furthermore, the conditions for the generalized second law of thermodynamics to be preserved are established with the constraints of positive temperature and attractive gravity. We illustrate our results for some concrete models in this theory

Svag analys ger allt för långtgående konsekvenser

DEFF Research Database (Denmark)

Thinggaard, Frank; Nilsson, Sven-Arne

2007-01-01

I IASB:s diskussionsrapport om möjliga värderingsgrunder vid första redovisningstillfället föreslås att tillgångar och skulder värderas till verkligt värde. I Balans 3/2007 redogjorde Frank Thinggaard och Sven-Arne Nilsson för kriterierna och tillvägagångssättet vid prövningen av relevans. I denn...

13.-20. VI võtab ehtekunstnike rühmitus F.F.F.F....

Index Scriptorium Estoniae

2004-01-01

Rühmitus F.F.F.F. (Ketli Tiitsar, Kristi Paap, Kaire Rannik, Berit Teeäär, Maria Valdma) võtab osa Bostonis toimuvast rahvusvahelisest ehtekunstinäitusest ja konverentsist "ContacT 2004", juhendab Massachusetts College of Art üliõpilastele ja kunstnikele korraldatud workshop'i "SWOP". Bakalar Gallerys esineb rühmitus näitusega "Igapäevaleib", osalejate individuaalset loomingut eksponeerib galerii Mobilia

Views of Elementary School Pre-Service Teachers About the Use of Educational Mathematics Games in Mathematics Teaching [Sınıf Öğretmeni Adaylarının İlköğretim Matematik Öğretiminde Eğitsel Bilgisayar Oyunlarının Kullanımına Yönelik Görüşleri

Directory of Open Access Journals (Sweden)

Hasan Topçu

2014-08-01

�ğrenmelerini daha kalıcı hale getirme, kavramları görselleştirme, eğlenerek öğrenme, öğrenilenleri pekiştirme, düşünme becerilerini geliştirme gibi faydalar sağlayacağını ifade ettikleri rapor edilmiştir. Bununla birlikte, sonuçlarda öğretmen adaylarının eğitsel bilgisayar oyunlarının bağımlılık oluşturma, fiziksel hasarlara yol açma, fazla zaman alma, özel bir donanım ve yazılım gerektirme, sınıf yönetiminin zorlaşması gibi sınırlılıklarından bahsettikleri de açıklanmıştır. Ayrıca, araştırma esnasında sınıf öğretmeni adaylarının oyunların derslerde kullanılması konusunda olumlu bir tutum sergiledikleri fakat uygulama konusunda mevcut durumda kendilerini yeterli hissetmedikleri de anlaşılmıştır.

Inhibition of H9N2 virus invasion into dendritic cells by the S-layer protein from L. acidophilus ATCC 4356

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Xue Gao

2016-10-01

Full Text Available Probiotics are essential for the prevention of virus invasion and the maintenance of the immune balance. However, the mechanism of competition between probiotics and virus are unknown. The objectives of this study were to isolate the surface layer (S-layer protein from L. acidophilus ATCC 4356 as a new antiviral material, to evaluate the stimulatory effects of the S-layer protein on mouse dendritic cells (DCs and to verify its ability to inhibit the invasion of H9N2 avian influenza virus (AIV in DCs. We found that the S-layer protein induced DCs activation and up-regulated the IL-10 secretion. The invasion and replication of the H9N2 virus in mouse DCs was successfully demonstrated. However, the invasion of H9N2 virus into DCs could be inhibited by treatment with the S-layer protein prior to infection, which was verified by the reduced hemagglutinin (HA and neuraminidase (NA mRNA expression, and nucleoprotein (NP protein expression in the DCs. Furthermore, treatment with the S-layer protein increases the Mx1, Isg15, and Ddx58 mRNA expressions, and remits the inflammatory process to inhibit H9N2 AIV infection. In conclusion, the S-layer protein stimulates the activation of mouse DCs, inhibits H9N2 virus invasion of DCs, and stimulates the IFN-I signalling pathway. Thus, the S-layer protein from Lactobacillus is a promising biological antiviral material for AIV prevention.

Tectona grandis L. f (the teak tree; Hindi: Sagallll or Segllll) (~r ...

Indian Academy of Sciences (India)

Tectona grandis L. f (the teak tree; Hindi: Sagallll or Segllll) (~r Verhell({Ceae is a large deciduous tree cllitivatedfor its timber. Leaves are large; flmvers are small, white, svveet-scented and borne on highly branched inflorescences. Fruit is hard and enveloped by bladder-like cal.vx. The timber is one of the best for all wood ...

5-(2-18F-fluoroethoxy)-L-tryptophan as a substrate of system L transport for tumor imaging by PET.

Science.gov (United States)

Krämer, Stefanie D; Mu, Linjing; Müller, Adrienne; Keller, Claudia; Kuznetsova, Olga F; Schweinsberg, Christian; Franck, Dominic; Müller, Cristina; Ross, Tobias L; Schibli, Roger; Ametamey, Simon M

2012-03-01

Large neutral l-amino acids are substrates of system L amino acid transporters. The level of one of these, LAT1, is increased in many tumors. Aromatic l-amino acids may also be substrates of aromatic l-amino acid decarboxylase (AADC), the level of which is enhanced in endocrine tumors. Increased amino acid uptake and subsequent decarboxylation result in the intracellular accumulation of the amino acid and its decarboxylation product. (18)F- and (11)C-labeled neutral aromatic amino acids, such as l-3,4-dihydroxy-6-(18)F-fluorophenylalanine ((18)F-FDOPA) and 5-hydroxy-l-[β-(11)C]tryptophan, are thus successfully used in PET to image endocrine tumors. However, 5-hydroxy-l-[β-(11)C]tryptophan has a relatively short physical half-life (20 min). In this work, we evaluated the in vitro and in vivo characteristics of the (18)F-labeled tryptophan analog 5-(2-(18)F-fluoroethoxy)-l-tryptophan ((18)F-l-FEHTP) as a PET probe for tumor imaging. (18)F-l-FEHTP was synthesized by no-carrier-added (18)F fluorination of 5-hydroxy-l-tryptophan. In vitro cell uptake and efflux of (18)F-l-FEHTP and (18)F-FDOPA were studied with NCI-H69 endocrine small cell lung cancer cells, PC-3 pseudoendocrine prostate cancer cells, and MDA-MB-231 exocrine breast cancer cells. Small-animal PET was performed with the respective xenograft-bearing mice. Tissues were analyzed for potential metabolites. (18)F-l-FEHTP specific activity and radiochemical purity were 50-150 GBq/μmol and greater than 95%, respectively. In vitro cell uptake of (18)F-l-FEHTP was between 48% and 113% of added radioactivity per milligram of protein within 60 min at 37°C and was blocked by greater than 95% in all tested cell lines by the LAT1/2 inhibitor 2-amino-2-norboranecarboxylic acid. (18)F-FDOPA uptake ranged from 26% to 53%/mg. PET studies revealed similar xenograft-to-reference tissue ratios for (18)F-l-FEHTP and (18)F-FDOPA at 30-45 min after injection. In contrast to the (18)F-FDOPA PET results, pretreatment with the

Defect model of a tetragonal Sm sup 3 sup + center found from EPR measurements in CaF sub 2 and SrF sub 2 crystals

CERN Document Server

Zheng Wen Chen; Wu Shao Yi; Tang Sheng

2003-01-01

The EPR parameters (g factors g sub p sub a sub r sub a sub l sub l sub e sub l , g sub p sub e sub r sub p sub e sub n sub d sub i sub c sub u sub l sub a sub r sub t sub o and hyperfine structure constants A sub p sub a sub r sub a sub l sub l sub e sub l , A sub p sub e sub r sub p sub e sub n sub d sub i sub c sub u sub l sub a sub r sub t sub o) of a tetragonal (C sub 4 sub v) Sm sup 3 sup + center in CaF sub 2 and SrF sub 2 crystals are calculated by considering the crystal-field J-mixing among the ground sup 6 H sub 5 sub / sub 2 , the first excited sup 6 H sub 7 sub / sub 2 and second excited sup 6 H sub 9 sub / sub 2 state multiplets. In the calculations the free-ion and crystal-field parameters of the tetragonal Sm sup 3 sup + -F sup - center obtained from polarized laser-selective excitation spectroscopy are used. The calculated results suggest that the tetragonal Sm sup 3 sup + -F sup - center is the Sm sup 3 sup + center found by later EPR measurements. The g factors g sub p sub a sub r sub a sub...

2-[{sup 18}F]fluoro-2-deoxy-D-glucose positron emission tomography (F.D.G.-PET) can identify chronic lymphocytic leukaemia (C.L.L.) stage A et stage B patients; La tomographie par emission de positons au 2-[{sup 18}F] fluoro-2-desoxy-D-glucose (TEP-FDG) permet d'identifier les stades A et B des leucemies lymphoides chroniques (LLC)

Energy Technology Data Exchange (ETDEWEB)

Berthelot, C.; Vervueren, L.; Le Jeune, J.J.; Couturier, O. [Centre Hospitalier Universitaire, Service de Medecine Nucleaire, 49 - Angers (France); Truchan-Graczyk, M.; Genevieve, F.; Ifrah, N. [Centre Hospitalier Universitaire, Service d' Hematologie, 49 - Angers (France); Poirier, A.L. [BEC, centre Paul-Papin, 49 -Angers (France); Artur-Guillemette, P. [Centre Hospitalier Universitaire, Service de Radiologie, 49 - Angers (France)

2009-09-15

Purpose: There is no data in the literature concerning the utility of 2-[{sup 18}F]fluoro-2-deoxy-d-glucose positron emission tomography (F.D.G.-PET) in chronic lymphocytic leukaemia (C.L.L.), except for the diagnosis of Richter's transformations. The purpose of this study was to assess the potential role of F.D.G.-PET in C.L.L. stages A and B. Materials and methods Thirty-five patients (61 {+-} 9 years; 11 women, 24 men; 8 B and 27 A) have benefited of a F.D.G.-PET scan at baseline, for example, before an eventual treatment. F.D.G.-PET scans were analyzed visually and the maximum values of the Standardised Uptake Value (S.U.V.{sub max}) were measured in the main lymph nodes areas. The ability of F.D.G.-PET to differentiate stages A and B patients was evaluated by Student's tests and Receiver Operating Characteristics (R.O.C.) analysis. Results All patients with a normal F.D.G.-PET (n = 18) were stages A. The remaining 17 patients (9 A and 8 B) showed hyper metabolisms in nodal areas above (n = 17) and below (n = 9) the diaphragm, and no visceral involvement. The lymph nodes hyper metabolisms were always bilateral, and of low intensity (= mediastinum; 9 A), or of higher intensity (= liver, 8 B). The S.U.V.{sub max} of stage B (n = 8) were significantly higher than those of the 27 stages A, in all lymph nodes areas except in mediastinum. The highest intensity of F.D.G. uptake was observed in axillary area in stages B patients (S.U.V.max = 2.74 {+-} 1.03). An axillary S.U.V.{sub max} of 1.33 is the most suitable value for the discrimination between stages A and B patients (R.O.C.; AUC = 0.968; sensitivity 1.00; specificity 0.91). Conclusion Lymph nodes hyper metabolisms are constant in the B stage, and more intense than in stage A. These anomalies are always bilateral, unlike what is observed in Richter's transformation. The intensity of axillary lymph nodes F.D.G. uptake can distinguish C.L.L. stages A and B. (authors)

Râhatü’l-İnsân (Pend-Nâme-i Enûşîrvân’ın Türkçe Bir Tercümesi A Turkish Translation of Râhatü’l-İnsân (Pend-Nâme-i Enûşîrvân

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Müjgân ÇAKIR

2012-09-01

Full Text Available Islamic literatures include many texts on the justice and counsels of Sassanian ruler Nûşîrevân. One of these is a work of Persian Literature which recounts the counsels written on his crown and figures with the titles of “Râhatü’l-insân” or “Pend-nâme-i Enûşîrvân” in some sources. Rıza Kulı Han Hidayet states that the text belongs to Bedâyi‛-i Belhî; however the identity of the author is disputed. It is also argued that the “Şerîf-i Şair,” whose name appears in the introduction to the text edited by Charles Schefer in his work entitled Chrestomathie Persane, is Ebû Şerîf Muhalledi-yi Gurgânî. Râhatü’l-insân has manuscripts in Turkish libraries. This article treats this work and its Turkish prose translation located at Süleymaniye Library, Fatih Section No. 5385 under the title “Pend-i Nûşîrevân-ı Âdil.” In this translation, the counsels written on the seventeen slices (küngüre of Nûşîrevân’s crown are given and it is told that this ruler had his crown put up somewhere appropriate every year for the soldiers to read his counsels. The purposes of Nûşîrevân’s counsels are proving a moral education to the public, directing his relations with his people as well as organizing the relations between them. Some of the counsels written on Nûşîrevân’s crown are as follows: “Respect the old and the weak, observe the rights of your parents, consult scholars before you do your business, have a command of your speech, do not betray trust, think before you speak.” The article will also treat some of the differences between the Persian manuscripts of the work and its Turkish translation. The transcription of the Turkish translation will be given. İslâmî edebiyatlarda Sasani hükümdarı Nûşîrevân’ın adaleti ve nasihatlarıyla ilgili birçok metin yazılmıştır. Bu metinlerden biri Fars Edebiyatı’nda onun tacının üzerinde yazılı olan nasihatları anlatan ve baz

Metoder och verktyg för motivation till och integration av arbetsmiljöarbete

OpenAIRE

Åteg, Mattias; Nygren, Olle; Andersson, Ing-Marie; Laring, Jonas; Neely, Greg; Rosén, Gunnar

2006-01-01

Rapporten utgår från forskningsområdet "Hur kan och bör arbetsmiljöarbete bedrivas och integreras i organisationers kärnverksamhet?" vid tema SMARTA, Arbetslivsinstitutet. I ett tidigare arbete har ett antal egenskaper identifierats som viktiga för motivation och engagemang för arbetsmiljöarbete, sk Moveit-egenskaper. Dessa egenskaper och deras roll i arbetsmiljöarbetet ställs här i relation till perspektivet integrerat arbetsmiljöarbete, där arbetsmiljön ingår i styrsystemet och arbetsmiljöa...

Radiosynthesis and biological evaluation of N-(2-[18F]fluoropropionyl)-3,4-dihydroxy-l-phenylalanine as a PET tracer for oncologic imaging.

Science.gov (United States)

Tang, Caihua; Nie, Dahong; Tang, Ganghua; Gao, Siyuan; Liu, Shaoyu; Wen, Fuhua; Tang, Xiaolan

2017-07-01

Several 11 C and 18 F labeled 3,4-dihydroxy-l-phenylalanine (l-DOPA) analogues have been used for neurologic and oncologic diseases, especially for brain tumors and neuroendocrine tumors PET imaging. However, 18 F-labeled N-substituted l-DOPA analogues have not been reported so far. In the current study, radiosynthesis and biological evaluation of a new 18 F-labeled l-DOPA analogue, N-(2-[ 18 F]fluoropropionyl)-3,4-dihydroxy-l-phenylalanine ([ 18 F]FPDOPA) for tumor PET imaging are performed. The synthesis of [ 18 F]FPDOPA was via a two-step reaction sequence from 4-nitrophenyl-2-[ 18 F]fluoropropionate ([ 18 F]NFP). The biodistribution of [ 18 F]FPDOPA was determined in normal Kunming mice. In vitro competitive inhibition and protein incorporation experiments were performed with SPC-A-1 lung adenocarcinoma cell lines. PET/CT studies of [ 18 F]FPDOPA were conducted in C6 rat glioma and SPC-A-1 human lung adenocarcinoma and H460 human large cell lung cancer-bearing nude mice. [ 18 F]FPDOPA was prepared with a decay-corrected radiochemical yield of 28±5% and a specific activity of 50±15GBq/μmol (n=10) within 125min. In vitro cell experiments showed that [ 18 F]FPDOPA uptake in SPC-A-1 cells was primarily transported through Na + -independent system L, with Na + -dependent system B 0,+ and system ASC partly involved in it. Biodistribution data in mice showed that renal-bladder route was the main excretory system of [ 18 F]FPDOPA. PET imaging demonstrated intense accumulation of [ 18 F]FPDOPA in several tumor xenografts, with (8.50±0.40)%ID/g in C6 glioma, (6.30±0.12)%ID/g in SPC-A-1 lung adenocarcinoma, and (6.50±0.10)%ID/g in H460 large cell lung cancer, respectively. A novel N-substituted 18 F-labeled L-DOPA analogue [ 18 F]FPDOPA is synthesized and evaluated in vitro and in vivo. The results support that [ 18 F]FPDOPA seems to be a potential PET tracer for tumor imaging, especially be a better potential PET tracer than [ 18 F]fluoro-2-deoxy-d-glucose ([ 18 F

Analysis of Major Item Redistribution/Substitution Policies. Volume 2

Science.gov (United States)

1980-05-01

HYu IKItPUIJ le I 113uu1qlesq9d .5 H r Lc1 I/36 L dI I U 4.1 Pc(C-i( F Jumi- ,iEU) 1e,uulu11f!)Vv I I H 4001 PI-1I I F nIALU "IIU l~lUUUei9daeb 1 3...LAl I d󈧭uu ldd11.v 1 I KK4eO9 IN/on1to rC Ft HYU LAI UIL d󈧭UOUIcde11U 1 2K HC-n I n6( 11- L b es/ A U- et41tiu0)4e4dd1 I c!K .5) 9 1 p FlI CAI oF...OULLY HYU ly Il Q910usiblf3o 2 1 .mm .󈧰Ub L VW Af’C UULL MUU Ml y 41 9vvbUt~dv) 1mM L I U Jd L 1 W 3 AC JLY Y Ty1 411Qu 41bUOUI66069 1 4 Li39h.lj’ AKl

Two-electron capture into autoionising configurations N/sup 4 +/(1snln'l') with n = 2,3,4 and n' >= n, observed by electron spectrometry in collisions of N/sup 6 +/(1s) with He and H/sub 2/, at 4. 2 keV amu/sup -1/

Energy Technology Data Exchange (ETDEWEB)

Bordenave-Montesquieu, A.; Benoit-Cattin, P.; Gleizes, A.; Marrakchi, A.I.; Dousson, S.; Hitz, D.

1984-04-14

Double electron transfer into autoionising states N/sup 4 +/(1snln'l'), with n = 2,3,4 and n' >= n has been observed in a collision between a one-electron highly charged N/sup 6 +/(1s) ion and a two-electron target (He or H/sub 2/), by electron spectrometry. The same configurations are excited in the two collisional systems but with very different probabilities. Electron capture mainly occurs into 1s2ln'l' in He-systems whereas transfer into 1s3ln'l' is stronger in H/sub 2/ systems.

Schedules of Controlled Substances: Temporary Placement of Six Synthetic Cannabinoids (5F-ADB, 5F-AMB, 5F-APINACA, ADB-FUBINACA, MDMB-

Science.gov (United States)

2016-12-21

The Administrator of the Drug Enforcement Administration is issuing this notice of intent to temporarily schedule six synthetic cannabinoids: methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [5F-ADB; 5F-MDMB-PINACA]; methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3-methylbutanoate [5F-AMB]; N-(adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide [5F-APINACA, 5F-AKB48]; N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3-carboxamide [ADB-FUBINACA]; methyl 2-(1-(cyclohexylmethyl)-1H-indole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-CHMICA, MMB-CHMINACA] and methyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate [MDMB-FUBINACA], into schedule I pursuant to the temporary scheduling provisions of the Controlled Substances Act (CSA). This action is based on a finding by the Administrator that the placement of these synthetic cannabinoids into schedule I of the Controlled Substances Act is necessary to avoid an imminent hazard to the public safety. Any final order will impose the administrative, civil, and criminal sanctions and regulatory controls applicable to schedule I substances under the Controlled Substances Act on the manufacture, distribution, possession, importation, exportation of, and research and conduct with, instructional activities of these synthetic cannabinoids.

f(R) gravity cosmology in scalar degree of freedom

International Nuclear Information System (INIS)

Goswami, Umananda Dev; Deka, Kabita

2014-01-01

The models of f(R) gravity belong to an important class of modified gravity models where the late time cosmic accelerated expansion is considered as the manifestation of the large scale modification of the force of gravity. f(R) gravity models can be expressed in terms of a scalar degree of freedom by explicit redefinition of model's variable. Here we report about the study of the features of cosmological parameters and hence the cosmological evolution using the scalar degree of freedom of the f(R) = ξR n gravity model in the Friedmann-Lemaître-Robertson-Walker (FLRW) background

Wrestling with empowerment: a BBBEE (Enterprise Development) case study and model for the waste sector from Durban

CSIR Research Space (South Africa)

Muswema, Aubrey P

2012-10-01

Full Text Available / . * + , - . / D 4 + 5 8 ' 4 2 ' E / F G H I J F K I H L M N N O P Q R S T Q Q U R S V N P W R S X Q L M N N U L T W R P L M S W L R V Y Z [ Q R \\ T W T S ] T Y ^ Y R Q T Q _ H ` ` a Q b U R Q Q T T S M Q ] c T V Z Y S T Y Q ] Z S T Z d T V Z S Z L R V W T e T N... T Q Z d j Z Z W l Y M V ] R V T U ] Z M Q Q R Q ] R S Q ] Y T S X ] c T S R S X M S W Q P ^ ^ Z Y ] R S X ] c R Q T L T Y X R S X Q T V ] Z Y m I c R Q ^ M ^ T Y W R Q V P Q Q T Q M Q P V V T Q Q d P N V M Q T Q ] P W n f c T Y T M S T L T Y X R S X...

r isotopes in the yrgueil gs meteoriteX ghronology of e rly sol r ...

Indian Academy of Sciences (India)

h ve een deposited intermittently st rting ne r the time of p rent ody form tion nd ontinuing for t le st QH w F he r .... mounts of w ter flowed through the yrgueil p rent m teri l during lter ... n lysis were rried outF pirstD series of le hing experiments ...

Le néo-corporatisme réinterpellé : analyse comparée de deux politiques d'accès à l'emploi, l'apprentissage industriel en Belgique et le contrat de qualification "jeunes" en France

OpenAIRE

Levêque, Audrey

2006-01-01

L'étude comparative de l'apprentissage industriel en Belgique francophone et du contrat de qualification "jeunes" en France permet de réinterpeller le modèle néo-corporatiste d'Etat social. L'analyse de l'émergence et de la mise en oeuvre de ces deux politiques publiques d'accès à l'emploi pour les jeunes peu qualifiés permet de comprendre comment elles sont réappropriées par les acteurs de terrain et ce, plus particulièrement dans la branche de la métallurgie. Si ces politiques s'adressent t...

Future dynamics in f(R) theories

International Nuclear Information System (INIS)

Mueller, D.; Andrade, V.C. de; Maia, C.; Reboucas, M.J.; Teixeira, A.F.F.

2015-01-01

The f(R) gravity theories provide an alternative way to explain the current cosmic acceleration without invoking a dark energy matter component used in the cosmological modeling in the framework of general relativity. However, the freedom in the choice of the functional forms of f(R) gives rise to the problem of the degeneracy among these gravity theories on theoretical and (or) observational grounds. In this paper we examine the question as to whether the future dynamics can be used to break the degeneracy between f(R) gravity theories by investigating the dynamics of spatially homogeneous and isotropic dust flat models in two f(R) gravity theories, namely the well known f(R) = R+αR n gravity and another byAviles et al., whose motivation comes from the cosmographic approach to f(R) gravity. We perform a detailed numerical study of the dynamics of these theories taking into account the recent constraints on the cosmological parameters made by the Planck Collaboration. We demonstrate that besides being useful for discriminating between these two f(R) gravity theories, the future dynamics technique can also be used to determine the finite-time behavior as well as the fate of the Universe in the framework of these f(R) gravity theories. There also emerges from our analysis the result that one still can have a dust flat FLRWsolution with a big rip, if gravity is governed by f(R) = R+αR n . We also show that FLRW dust solutions with f'' < 0 do not necessarily lead to singularities. (orig.)

2-(2-Chlorobenzoylimino)-1,3-thiazolidine: structure refinement from neutron diffraction data at 113 K and charge density deformation maps

International Nuclear Information System (INIS)

Cohen-Addad, C.; Savariault, J.-M.; Lehmann, M.S.

1981-01-01

The structure of 2-(2-chlorobenzoylimino)-1,3-thiazolidine, C 10 H 9 ClN 2 OS, has been redetermined by neutron diffraction at 113 K. The space group is P2 1 /c with lattice parameters a = 19.950 (4), b = 7.420 (2), c = 11.566 (3) A, β = 109.10 (3) 0 , Z = 4, Msub(r) = 240.7 and dsub(calc) = 1.52 Mg m -3 . The final R(F 2 ) was 0.045 for 1768 reflections. The structural results show unambiguously that the molecule is found in the imino form with an H atom located near the endocyclic N atom of the thiazolidine group. Based on deformation electron density maps and the interatomic distances it is speculated that the difference in geometry between the two tautomeric forms (imino and amino) is small and that the occurrence of one or the other is strongly dependent on the substituents. A short intramolecular S-O contact of 2.68 A is found and is believed to constitute a very weak bond. (Auth.)

[Book Review] Bykhovskaya-Pavllvskaya: Key to parasites of freshwater fish of the U.S.S.R

Science.gov (United States)

Hoffman, G.L.

1966-01-01

Review of: Key to parasites of freshwater fish of the U.S.S.R. Opredelitel' parazitov presnovodnykh ryb SSSR. Compiled by I. E. Bykhovskaya-Pavlovskaya [and others] Assisted by L. F. Nagibina, E. V. Baikova, and Yu. A. Strelkov. Chief Editor: E. N. Pavlovskii. Translated from Russian [by A. Birron and Z.S. Cole] Published 1964 by Israel Program for Scientific Translations, [available from the Office of Technical Services, U.S. Dept. of Commerce, Washington] in Jerusalem.

Cürufa Olan Bakır Kayıplarında Farklı Kroze Kullanımının Etkisi

OpenAIRE

RÜŞEN, Aydın

2017-01-01

Bakır işletmelerinde ergitme aşamasında cürufa olan bakır kayıpları sektördeki önemli problemlerdenbiridir. Bu çalışmada, Eti Bakır İşletmelerinden (EBİ) temin edilen flaş fırın cürufu ve flaş fırın matı eşitmiktarlarda alınarak farklı oranlarda kolemanit (2CaO·3B2O3·5H2O) ilavesi (%0, %2, %4 ve %6) ilekarıştırılıp alumina (Al2O3) krozelerde 1250oC’de ve azot atmosferi altında 2 saat boyunca ergitmedeneylerine tabi tutulmuştur. Böylece, alümina kroze (AK) kullanılan deneylerde cürufa olan bak...

Effects of pH, temperature, and chemical structure on the stability of S-(purin-6-yl)-L-cysteine: evidence for a novel molecular rearrangement mechanism to yield N-(purin-6-yl)-L-cysteine.

Science.gov (United States)

Elfarra, A A; Hwang, I Y

1996-01-01

The stability of S-(purin-6-yl)-L-cysteine (SPC), a kidney-selective prodrug of 6-mercaptopurine and a putative metabolite of 6-chloropurine, was investigated under various pH and temperature conditions. At room temperature, the half-life (t 1/2) of SPC at either highly acidic (pH 3.6) or basic conditions (pH 9.6) was longer than at neutral or slightly acidic or basic conditions (pH 5.7-8.75). The primary degradation product, N-(purin-6-yl)-L-cysteine (NPC), was isolated using Sephadex LH-20 chromatography and characterized by 1H NMR and FAB/MS after derivatization with 2-iodoacetic acid. These results reveal novel stability requirements and implicate the cysteinyl amino group and the purinyl N-1 nitrogen in the mechanism of SPC rearrangement to NPC. Further evidence for this hypothesis was provided by the findings that the stability of SPC in phosphate buffer (pH 7.4) at 37 degrees C was similar to that of S-(guanin-6-yl)-L-cysteine, whereas S-(purin-6-yl)-N-acetyl-L-cysteine and S-(purin-6-yl)glutathione which have their cysteine amino groups blocked were much more stable than SPC. S-(Purin-6-yl)-L-homocysteine (SPHC) was also more stable than SPC, possibly because the formation of a 6-membered ring transition state as would be expected with SPHC is kinetically less favored than the formation of a 5-membered ring transition state as would be expected with SPC. These results may explain previous in vivo metabolism results of SPC and its analogs and may contribute to a better understanding of stability of structurally related cysteine S-conjugates.

Enzymatic function of loop movement in enolase: preparation and some properties of H159N, H159A, H159F, and N207A enolases.

Science.gov (United States)

Brewer, John M; Glover, Claiborne V C; Holland, Michael J; Lebioda, Lukasz

2003-05-01

The hypothesis that His159 in yeast enolase moves on a polypeptide loop to protonate the phosphoryl of 2-phosphoglycerate to initiate its conversion to phosphoenolpyruvate was tested by preparing H159N, H159A, and H159F enolases. These have 0.07%-0.25% of the native activity under standard assay conditions and the pH dependence of maximum velocities of H159A and H159N mutants is markedly altered. Activation by Mg2+ is biphasic, with the smaller Mg2+ activation constant closer to that of the "catalytic" Mg2+ binding site of native enolase and the larger in the mM range in which native enolase is inhibited. A third Mg2+ may bind to the phosphoryl, functionally replacing proton donation by His159. N207A enolase lacks an intersubunit interaction that stabilizes the closed loop(s) conformation when 2-phosphoglycerate binds. It has 21% of the native activity, also exhibits biphasic Mg2+ activation, and its reaction with the aldehyde analogue of the substrate is more strongly inhibited than is its normal enzymatic reaction. Polypeptide loop(s) closure may keep a proton from His159 interacting with the substrate phosphoryl oxygen long enough to stabilize a carbanion intermediate.

Écologie bactérienne de l'infection nosocomiale au service de réanimation de l'hôpital Laquintinie de Douala, Cameroun

Science.gov (United States)

Njall, Clotilde; Adiogo, Dieudonné; Bita, André; Ateba, Noel; Sume, Gérald; Kollo, Basile; Binam, Fidèle; Tchoua, Romain

2013-01-01

Introduction L'objectif principal de notre étude était d'identifier les bactéries associées à l'infection nosocomiale, dans le service de réanimation, de l'hôpital Laquintinie de Douala en vue d'améliorer la prise en charge et diminuer la létalité. Méthodes Il s'agissait d'une étude transversale et descriptive, menée du 1er mars au 31 mai 2011.Tous les patients hospitalisés depuis au moins 48 h étaient inclus dans l’étude et ceux présentant une infection documentée à l'admission étaient exclus. L'analyse des donnés a été faite par le logiciel SPSS 16.Les tests de Khi deux pour la signification. Résultats La prévalence de l'infection nosocomiale était de 12%, elle concernait des personnes âgées de plus de 60 ans et présentant une infection urinaire dans 79% des cas. La létalité était de 72% pour une durée moyenne de séjour de 11,7 ± 12,1 jours. Les bactéries responsables étaient en majorité des bactéries gram positifs (BGN), dont E coli dans 23,1% et les cocci gram positifs(CGP), dans 15,4% des cas. Conclusion L’étude de la résistance aux antibiotiques, montre une multi résistance, dont il faut tenir compte en mettant en place une stratégie de prévention active. PMID:23785545

Whey and casein labelled with L-[1-13C]-leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion

DEFF Research Database (Denmark)

Reitelseder, Søren; Agergaard, Jakob; Doessing, Simon

2011-01-01

to a single bolus intake of whey or casein after performance of heavy resistance exercise. Young male individuals were randomly assigned to participate in two protein trials (n = 9) or one control trial (n = 8). Infusion of l-[1-(13)C]leucine was carried out, and either whey, casein (0.3 g/kg lean body mass......), or a noncaloric control drink was ingested immediately after exercise. l-[1-(13)C]leucine-labeled whey and casein were used while muscle protein synthesis (MPS) was assessed. Blood and muscle tissue samples were collected to measure systemic hormone and amino acid concentrations, tracer enrichments......, and myofibrillar protein synthesis. Western blots were used to investigate the Akt signaling pathway. Plasma insulin and branched-chain amino acid concentrations increased to a greater extent after ingestion of whey compared with casein. Myofibrillar protein synthesis was equally increased 1-6 h postexercise after...

Wrestling with IWMP implementation: case study challenges and lessons learnt

CSIR Research Space (South Africa)

Muswema, Aubrey P

2012-10-01

Full Text Available / A / . * + , - . / D 4 + 5 8 ' 4 2 ' E / ' F G H I J F K I L M N O P Q R N O S T R U N O V R M R P O W O M N X Y R M M Z M P [ L T V X \\ ] R U Q O ^ _ P M Z U O S R U R U ` _ Q N a N O Q W U N Q R N O P b Z M Z N Z R N Z c O d _ Q N ` O e f g Y Z... ^ R M S e Q Z c R N O U O ^ N _ Q Z M N ` O h R N Z _ M R Y T R U N O V R M R P O W O M N H N Q R N O P b R U d R Q g R ^ i R U j k k k [ l m F I n j k k k \\ o I O M b O R Q U Y R N O Q n N ` Q _ f P ` N ` O T R U N O F ^ N _ M j p f Y b q r r k n N...

Yoğurt Yapımında Yararlanılan L. bulgaricus ve S. thermophilus’un Proteolitik Aktivitelerinin Belirlenmesi

Directory of Open Access Journals (Sweden)

Sevda Kılıç

2015-02-01

Full Text Available Yoğurt bakterilerinin süte aşılandıktan sonra enzimatik etkinlikleri sonucu proteinleri parçalamaları olayına proteoliz adı verilir. Bu olay sırasında ortamda gerekli gelişme faktörleri meydana geldiğinden S. thermophilus’un gelişmesi ve çoğalması hızlandırılmış olur. Simbiyotik faaliyet gösteren bu bakteriler için gerekli ve yararlı olan proteoliz olayının yoğurt yapımında ancak belirli bir düzeyde meydana gelmesi istenir. ASPERGER, tirosin aminoasiti ile aroma oluşumu arasında bir ilişkinin olduğunu, tirosin içeriğinin 0.05-0.1 mg/ml olması durumunda yoğurtların istenen aromaya sahip olabileceğini bildirmiştir. 0.125 mg/ml tirosin içeren yoğurt örneklerinde ise hafif acı tat oluştuğu bildirilmiştir. Bundan hareketle yoğurt bakterileri olan L. bulgaricus ile S. thermophilus’ a ait suşların proteolitik aktiviteleri HULL yöntemine göre tirosin ekivalantı üzerinden belirlenmeye çalışılmıştır. Araştırmada genellikle yüksek asitlik oluşturabilen L. bulgaricus suşlarının daha fazla proteolitik aktivite gösterdikleri saptanmıştır. Ancak bütün bakteri suşları için bu durumun geçerli olmadığı da belirlenmiştir. 20 L. bulgaricus suşuna ait değerlerin 0.105-0.215 mg tirosin/ml sınırları arasında değiştiği gözlenmiştir. S. thermophilus’un denemeye alınan 20 suşu için saptanan değerler de 0.080-0.070 mg tirosin/ml arasında belirlenmiş olup değerlerin L. bulgaricus’ a ait değerlerden çok düşük olduğu anlaşılmıştır.

Bölge farklılığı, buharlama, kurutma sıcaklığı, tutkal türü ve tabaka sayısının Ladin odunundan üretilen kontrplakların bazı mekanik özelliklerine etkisi

Directory of Open Access Journals (Sweden)

Doç.Dr. Hüseyin PEKER

2014-12-01

Full Text Available Bu çalışmada, bölge farklılığı, buharlama işlemi, kurutma sıcaklığı, tabaka sayısı ve tutkal türünün Ladin odunundan üretilen kontrplakların mekanik özelliklerine (eğilme direnci ve elastikiyet modülü etkisi belirlenmeye çalışılmıştır. Doğu Karadeniz Yöresi’nin (Rize Çayeli/Çürükbel ve Trabzon Maçka/Kapıköy mevkilerinden temin edilen Doğu ladini (Picea orientalis L. deney örnekleri fenol formaldehit ve melamin üre formaldehit tutkallarıyla beraber işleme tabi tutularak 5 ve 7 tabakalı kontrplak levhalar hazırlanmıştır.Deney sonuçlarına göre; Eğilme direnci en yüksek değer 6 saat buharlanmış ve 1100C kurutma sıcaklığı ortamında fenol formaldehit tutkalı ile işlem görmüş 5 tabakalı (Maçka ladin odununda gerçekleşirken; Elastikiyet modülünde ise en yüksek değer 7 tabakalı kontrplak levhalarında 12 saat buharlanmış ve 1100C kurutma sıcaklığı ortamında fenol formaldehit tutkalı ile işlem görmüş (Maçka Ladin odununda gerçekleşmiştir.

Risques liés à la gestion des résidus de l'assainissement

OpenAIRE

EISENLOHR, Laurent; DENOT, Agathe; BOBILLON, Guy; VAN DER HAEGEN, Sébastien

2009-01-01

La réutilisation des terres de curage de fossés et des sédiments de bassins routiers est conditionnée par les concentrations en hydrocarbures et en ETM. Il n'existe aucun seuil établi pour orienter ces résidus, ce qui complique fortement leur gestion. La détermination des seuils passe donc par la réalisation d'études du risque sanitaire associé aux différentes filières. La politique française en matière de sites et sols pollués s'appuie sur deux concepts principaux : - l'examen du risque p...

Late-time cosmological evolution of a general class of f(R, T) gravity with minimal curvature-matter coupling

Energy Technology Data Exchange (ETDEWEB)

Shabani, Hamid [University of Sistan and Baluchestan, Physics Department, Faculty of Sciences, Zahedan (Iran, Islamic Republic of); Ziaie, Amir Hadi [Islamic Azad University, Department of Physics, Kahnooj Branch, Kerman (Iran, Islamic Republic of)

2017-08-15

In this work, we study the late-time cosmological solutions of f(R, T) = g(R) + h(-T) models assuming that the conservation of the energy-momentum tensor (EMT) is violated. We perform our analysis through constructing an autonomous dynamical system for the equations of motion. We study the stability properties of solutions via considering linear perturbations about the related equilibrium points. Moreover, we parameterize the Lagrangian by introducing the parameters m(r) and n(s). These parameters which are constructed out of the functions g(R) and h(-T) play the main role in finding the late-time behavior of the solutions. We find that there exist, in general, three classes of solutions; all models with n > 0 include a proper transition from a prolonged matter era to a de Sitter solution. Models with -0.5 < n < 0 and n{sup '} > 1, for at least a root of equation n(s) = s - 1, include an unphysical dark energy solution preceding an improper matter era. Finally, for n < -1/2 there is a transient accelerated expansion era with -1/2 < w{sup (eff)} < -1/3 before a de Sitter phase. For all cases, in order to have a long enough matter dominated epoch, the condition m{sup '} → 0{sup +} for r f(R, T) = R{sup β} + (-T){sup α} can be observationally motivating for m → 0{sup +} and -0.024 < α < 0.02 and therefore could provide a suitable setting for later investigations. (orig.)

Características fisicoquímicas de nueve híbridos de sorgo (Sorghum bicolor L. Moench y su relación con el contenido de almidón y digestión ruminal

Directory of Open Access Journals (Sweden)

Mariana Villarreal-Silva

2015-01-01

Full Text Available Nueve híbridos de sorgo (Sorghum bicolor L. Moench se analizaron para determinar la relación de suscaracterísticas físicas [materia seca (MS, peso de mil granos (PMG, tamaño de partícula (TP, densidad relativa(DR, superficie de área (SA, partículas por gramo (PPG, endospermo duro (END-DU, endospermo blando (ENDBL];y químicas [nitrógeno total (NT, fibra detergente ácido (FDA, fibra detergente neutro (FDN, contenidode almidón (ALM, almidón soluble (AlmS, almidón insoluble (AlmNS. La digestión ruminal esperada (DRUMse estimó con las fracciones de AlmS y AlmNS in vitro. El promedio de PMG, TP, DR, SA, PPG y END-DU fuede 24.61 g, 3.17 mm, 1.30 g/cm3, 17.44 cm2/g, 30.33 y 46.68 %, respectivamente El promedio (% de MS, PC,FDN, FDA, ALM, AlmS y AlmNS fue de 92.47, 8.19, 19.17 y 8.30, 69.58, 6.00 y 47.74 respectivamente. Laconcentración de taninos fue baja (0.05 entre las variables físicas o químicas con el contenido total de almidón en el grano;sin embargo las variables densidad relativa y superficie de área, permiten incrementar el poder de predicciónde la digestibilidad ruminal del almidón (DRUM,%= 74.058 - 0.108END-DU + 0.027SA – 5.887DR, R2= 0.77,P<0.05. De acuerdo a los resultados obtenidos, las variedades estudiadas son de dureza intermedia, libres detaninos y con un potencial de digestibilidad ruminal del almidón del 66 %.

Vad och hur gör de? − att synliggöra lärande i grundskolans slöjdpraktik via videoetnografi och mikroanalys

Directory of Open Access Journals (Sweden)

Marléne Johansson

2011-11-01

Full Text Available Artikeln bygger på resultat och erfarenheter av etnografiskt insamlade videoinspelningar från grundskolans slöjdundervisning utgående från tre studier; dels vid ett projekt med förstudier under slutet av 1990-talet (Johansson, 1996, dels vid avhandlingsprojektet Slöjdpraktik i skolan (Johansson, 2002 och dels inom forskningsprojektet Kommunikation och lärande i slöjdpraktiker, (”Komolär-projektet”, under 2005−2010 (Lindström, Borg, Johansson & Lindberg, 2003.Att insamla empiri i autentiska slöjdmiljöer är av intresse då lärandesituationer kan synliggöras när elever med hjälp av material och redskap arbetar med att tillverka artefakter. Utifrån detaljerade analyser av slöjdaktiviteter går det att upptäcka det som utspelar sig och möjligheter ges att uppfatta något annat jämfört med vad man kan tro känna väl eller ha förenklade och till och med felaktiga uppfattningar om. Videoobservationer möjliggör att antaganden istället görs på empiriskt grundat datamaterial. Med risk att videofilma och analysera det man tror sig veta och söka har forskningsprojektens insamlingar mer förutsättningslöst arbetat efter vad och hur elever och lärare gör i slöjdpraktik och vad man får veta när slöjdaktiviteter analyseras mer ingående. Videomaterialen har analyserats både på en mer övergripande nivå och detaljerat med hjälp av mikroanalyser. Därefter har lärandet synliggjorts och beskrivits bland annat i teman för att visa hur personerna är resurser för varandra och hur lärandet utvecklas genom olika språkanvändning och med slöjdpraktikens fysiska redskap och material.Sökord: metod, slöjd, klassrumsforskning, videoetnografi, mikroanalysURN:NBN:no-29955

Översikt och detaljstudium av hårdvara för laborationer i datorteknik

OpenAIRE

Pettersson, Joel

2015-01-01

Detta kandidatexamensarbete avser att bidra till att hålla utbildningen i datorteknik på KTH i Stockholm uppdaterad. Möjligheten undersöks att i laborationer i datorteknik ersätta Alteras DE2-kort med enkortsdatorn Chipkit Uno32. Den centrala frågan är vilken effekt ett sådant byte skulle ha på utvecklingsmiljön i kursen. För att ta fram beslutsunderlag kring Uno32, experimenterar jag med att utveckla relevanta program på enkortsdatorn. Detta arbete samlar min erfarenheter. Jag beskriver två ...

Kriz Dönemlerinde Türk Bankacılık Sektörünün Toplam Faktör Verimlilik Değişimi

OpenAIRE

Ferda Keskin Önen; Mehmet Hasan Eken; Süleyman Kale

2016-01-01

Bankaların etkinliğini arttırabilmenin ön koşulu rekabet edilebilirliktir. Rekabet gücü yüksek bankacılık sektörü ile ekonomik dinamizm arttırılır ve ekonomik istikrar ortamı sağlanır. Makro ekonomik koşullardaki değişim, bankacılık sektörünün performansını ve finansal istikrarı etkilemektedir. Bu çalışmada 1990 - 2012 döneminde faaliyet gösteren 19 mevduat bankasının aracılık ve karlılık yaklaşımına göre etkinliklerini analiz etmek için Malmquist Verimlilik Endeksi kullanılmıştır. Bankalar, ...

R. F. plasmoids and resonant discharges; Plasmoides a haute frequence et decharges resonnantes

Energy Technology Data Exchange (ETDEWEB)

Taillet, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-06-15

In R.F. discharges at reduced pressure a resonance can increase by an order of magnitude the intensity of the plasma R.F. electric field. The electron density of the plasma adjusts itself to keep the resonant frequency equal to the excitation frequency. This behaviour has been observed by an electron beam technique. When such a discharge is excited in electronegative gases, the negative ion density may be higher than the electron density. Therefore, the D.C. potential distribution in plasma and sheath is modified. The plasma appears as a luminous body isolated from the walls by a large sheath (R.F. plasmoid). (author) [French] Dans les decharges H.F. a faible pression une resonance peut elever d'un ordre de grandeur l'intensite du champ electrique interne du plasma. La densite electronique s'ajuste elle-meme de facon a rendre egales la frequence d'excitation et la frequence de la resonance. Ce mecanisme a ete observe a l'aide de faisceaux electroniques. Lorsqu'une telle decharge est excitee dans un gaz electronegatif, la densite des ions negatifs peut etre plus elevee, que la densite electronique, ce qui modifie la distribution du potentiel continu dans le plasma et la gaine. Le plasma apparait comme un corps lumineux isole des parois par une large gaine (plasmoide a haute frequence). (auteur)

R. F. plasmoids and resonant discharges; Plasmoides a haute frequence et decharges resonnantes

Energy Technology Data Exchange (ETDEWEB)

Taillet, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1964-06-15

In R.F. discharges at reduced pressure a resonance can increase by an order of magnitude the intensity of the plasma R.F. electric field. The electron density of the plasma adjusts itself to keep the resonant frequency equal to the excitation frequency. This behaviour has been observed by an electron beam technique. When such a discharge is excited in electronegative gases, the negative ion density may be higher than the electron density. Therefore, the D.C. potential distribution in plasma and sheath is modified. The plasma appears as a luminous body isolated from the walls by a large sheath (R.F. plasmoid). (author) [French] Dans les decharges H.F. a faible pression une resonance peut elever d'un ordre de grandeur l'intensite du champ electrique interne du plasma. La densite electronique s'ajuste elle-meme de facon a rendre egales la frequence d'excitation et la frequence de la resonance. Ce mecanisme a ete observe a l'aide de faisceaux electroniques. Lorsqu'une telle decharge est excitee dans un gaz electronegatif, la densite des ions negatifs peut etre plus elevee, que la densite electronique, ce qui modifie la distribution du potentiel continu dans le plasma et la gaine. Le plasma apparait comme un corps lumineux isole des parois par une large gaine (plasmoide a haute frequence). (auteur)

"Vi är inte en tummelplats för dårar" : Hur journalister och ansvariga utgivare resonerar kring och förhåller sig till användargenererat material i lokaltidningar

OpenAIRE

Öberg, Therese; Borgström, Johanna

2010-01-01

Sedan 1700-talet har läsarnas medverkan varit en väsentlig del i tidningarnas produktion. Utan deras deltagande har det inte heller blivit någon tidning. En förändring på området skedde när professionaliseringen av publicistrollen blev ett faktum och läsarnas medverkan ifrågasattes. Samhällsförändringar och tekniska utvecklingar har sedan lett fram till det vi har idag: ett samhälle där medieorganisationerna är i allt större behov av att läsarna återigen deltar i olika former. Syftet med stud...

Römorkörcülük Hizmeti Yetki Sahalarında Römorkör Sayısının Simülasyon Modellemesi Yöntemiyle Tespiti

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Selçuk NAS

2016-03-01

Full Text Available Römorkörcülük hizmeti verecek bir teşkilatın ilk yatırım maliyetlerinin oldukça yüksek olması nedeniyle, yapılacak yatırımlarda yetki sahası boyutlarına göre belirlenmiş hizmet düzeyini sağlayacak römorkör sayısının, tipinin ve çeki kuvvetlerinin tespiti verimlilik açısından oldukça önemlidir. Her ne kadar serbest rekabet nedeniyle belli bir yetki sahasında ihtiyaçtan fazla römorkör olsa da, yeni pazara giren hizmet sağlayıcılarının deniz trafiğine ait istatistiki verileri analiz ederek optimum sayıdaki römorkörü elinde tutarak rekabetçi gücünü arttırması mümkündür. Bu çalışmada yalnızca römorkör sayısı üzerinde durulmuş olup, genel bir limandaki deniz trafiğine ait bağımsız değişkenlerin, römorkör sayısına ait bağımlı değişken üzerindeki rassal etkilerinin analiz edilebileceği bir simülasyon modeli geliştirilmiştir. Simülasyon modellemesinde Promodel 2011 programı kullanılmıştır. Elde edilen veriler Stat:Fit programı yardımıyla analiz edilmiştir. Sonuç olarak, yetki sahalarında gerekli römorkör sayısının tespit edilebileceği ve her alanda uygulanabilecek bir simülasyon modeli geliştirilmiştir.

Novel 19F MRS/I nanoprobe based on pH-responsive PEGylated nanogel. pH-dependent 19F magnetic resonance studies

International Nuclear Information System (INIS)

Oishi, Motoi; Sumitani, Shogo; Nagasaki, Yukio; Bronich, Tatiana K.; Kabanov, Alexander V.; Boska, Michael D.

2009-01-01

The pH-responsive PEGylated nanogels composed of the cross-linked poly[2-(N,N-diethylamino)ethyl methacrylate]-co-poly(2,2,2-trifluoroethyl methacrylate) gel core showed a remarkable on-off regulation of 19 F magnetic resonance signal intensity (T 2 values) as well as signal-to-noise ratios in response to extracellular pH 6.5 of tumor environment under 19 F magnetic resonance spectroscopic imaging (MRS/I), demonstrating the utility of the PEGylated nanogels as solid tumor-specific 19 F MRI/S nanoprobes. (author)

Sanal Gerçeklik Programlarının Astronomi Konularının Öğretiminde Kullanılmasının Akademik Başarı ve Kalıcılığa Etkisi

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Hilal Aktamış

2012-11-01

Full Text Available Bu araştırmada üç boyutlu görsel tasarımları içeren sanal gerçeklik programlarının, ilköğretim 7. sınıf öğrencilerinin fen ve teknoloji dersi astronomi konusundaki başarılarına ve kalıcılıklarına etkisini araştırmak amaçlanmıştır. Bu kapsamda ilköğretim 7. sınıf öğrencilerinin zihinlerinde astronomi konularını daha iyi yapılandırabilmesi için sanal gerçeklik programlarına uygun etkinlik yaprakları geliştirilmiş ve Aydın ilinde sosyoekonomik bakımdan alt düzeydeki bir İlköğretim okulunda yer alan yedinci sınıf öğrencilerine uygulanmıştır. Araştırmanın çalışma grubunu deney grubunda 30, kontrol grubunda 30 öğrenci olmak üzere toplam 60 öğrenci oluşturmaktadır. Araştırmada kullanılan 20 maddelik Astronomi Başarı Testi'nin cronbach alfa güvenirlik katsayısı .76 olarak hesaplanmış ve çalışma grubundaki öğrencilere uygulama öncesi ön test, uygulama sonrası son test ve uygulamadan üç ay sonra kalıcılık testi olarak uygulanmıştır. Uygulama sonucuna göre sanal gerçeklik programları kullanılarak yapılan öğretim sonucunda deney grubunun akademik başarısının kontrol grubuna göre daha fazla arttığı görülmüştür. Sanal gerçeklik programları kullanılarak yapılan öğretimin öğrencilerin akademik başarılarını arttırmada daha etkili olduğu ortaya çıkmıştır.

EFFECT OF LEVAMISOLE ON POTENTIATION OF CELL MEDIATED IMMNITY IN RHEUMATOID ARTHRITIS

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MASSOUD A

1981-05-01

Full Text Available The leukocyte mi gration test (LHT in the prese nce of na t i v e IgG, and l l e v amis ole were studi ed in 9 patients su f f e ring from cla s s i c a l r h e umatoid ar.thri t i s be f o r e a nd after treatment with l evamisole . Fi f teen heal thy b l o od dono rs we r e s i mi l a r ly l nvestig ated a s cont r o ls ."nT- l ympho c yte s ub-popu lations (To ta l a nd active a nd B-c el l s were als o measured i n both g r o ups simult ane ous l y by E a nd EAC- rosette fo rma t ion Th e results show a significantly diminished leukocyte i nh i b i t o r y fac tor (LIP i n t he p r e sence of nativ a IgG after trea tment wi t h l e v ami s o l e a nd a signifi c a nt inc r e a s e o f active T- c ells in th i s g roup o f patie n t s. In add i t i o n a f t e r treatment tIle Inigration i nde x"nshow an increase i n t he presence o f l e v ami s o l e. We have a lso o b s e r v e d a good cor r e l a t ion between the clinical response o f l e vami sole and ou r immunological d a t a.

Mevlânâ’da İlahî Sıfatlar The Divine Attributes in Mawlānā Jalāl al-Dīn al-Rūmī

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Tuna TUNAGÖZ

2013-03-01

ündeönemli bir konuma sahip olan sûfî şair ve düşünür Mevlânâ Celâleddîner-Rûmî’nin (ö. H.672/M.1273 ilâhî sıfat anlayışı, kelâmcılarıngörüşleriyle kıyaslanarak incelenmiştir. Allah’a inanılmasını isteyenKur'an’ın, Allah’ın varlığından ve O’nun varlığı ile ilgili konulardanbahsetmesi beklenecek bir durumdur. Her ne kadar ilâhî isimleri önplana çıkarıp teorik detayları bir kenara bıraksa da, Tanrı’nın nitelikleriKur'an’ın ilgi sahası içerisinde yer alır. Kelâmcılar bu nasları Yunanfelsefesinin desteğiyle rasyonel olarak ayrıntılama ve sistemleştirmeyoluna gitmişlerdir. Aralarında Mevlânâ da olmak üzere sûfîler ise Tanrıhakkında elde edilebilecek bilgiyi ruhsal arınmanın ortaya koyduğukeşfe, ilhama, yani dinî tecrübeye indirgerler. Her iki ekolün arasındakiayrılığın özünü de bu metot farklılığı oluşturmaktadır. Bilindiği üzere,Sünnî kelâmın ilâhî sıfat anlayışı, zatla sıfatları aynı gören Mu’tezilîkelâmın antitezidir. Sünnî tez, Allah’ın sıfatlara hakiki anlamda sahipolması, bu sıfatların da O’nun zatının ne aynı ne de gayrı olduğuşeklinde özetlenebilir. Çalışmamızın konusu olan Mevlânâ’nın ilâhîsıfatlara ilişkin görüşleri, bariz biçimde Sünnî kelâm ile uyumludur.Allah’a “nefsî, selbî, subûtî, fiilî ve haberî” sıfatlar izafe eden düşünür,bu görüşlerini daha çok şiirler içerisinde sistemsiz biçimde vermekte veteorik detaylara girmemektedir. Fakat Sünnî kelâmcılarla olanmutabakat, Mevlânâ’nın sıfat anlayışının sadece bir yönünü ifade eder.Çünkü Mevlânâ, en başta “varlık ve bilgi” anlayışları olmak üzere,tasavvufî düşünce ile kelâmî düşüncenin ayrıştığı noktalarda, tercihinitasavvufî paradigmadan yana kullanmakta ve bunu ürettiği tüm pratikve teorik sonuçlara yansıtmaktadır.

A R2R3-MYB Gene LfMYB113 is Responsible for Autumn Leaf Coloration in Formosan sweet gum (Liquidambar formosana Hance).

Science.gov (United States)

Wen, Chi-Hsiang; Chu, Fang-Hua

2017-03-01

The regulation of autumn leaf coloration in deciduous trees has long been an enigma. Due to the fact that different coloration phenotypes may be considered when planting, more understanding of the regulation mechanism is needed. In this study, a R2R3-MYB transcription factor gene LfMYB113 was identified from a subtropical deciduous tree species Formosan sweet gum (Liquidambar formosana Hance). The expression patterns of LfMYB113 in four selected phenotypes were different and were positively correlated with leaf anthocyanin content. In a 35S::LfMYB113 transgenic Nicotiana tabacum plant, both the early and late genes in the anthocyanin biosynthetic pathway were shown to be up-regulated. It was also shown that LfMYB113 can activate the promoter sequence of LfDFR1 and LfDFR2. Transient overexpression of LfMYB113 in Nicotiana benthamiana showed strong anthocyanin accumulation and pre-senescence; the latter was confirmed by up-regulation of senescence-associated genes. In addition, the activation of proLfSGR::YFP by LfMYB113 in transient experiments indicated that LfMYB113 may have a role in regulation of Chl degradation. To our knowledge, this is the first time a R2R3-MYB transcription factor has been functionally identified as one of the key regulators of autumn leaf coloration and autumn leaf senescence. © The Author 2017. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

The Role of the Transcription Factors MtrR and MtrA in the Fitness of the Pathogen Neisseria gonorrhoeae

Science.gov (United States)

2007-10-19

1318- 1324. 45. Fath, M. J., and R. Kolter . 1993. ABC transporters: bacterial exporters. Microbiol Rev 57:995-1017. 46. Fichorova, R. N., P. J. Desai, F...incidence estimates of selected curable STDs. Sex Transm Infect 74 Suppll:S12-16. 54. Gilson, L., H. K. Mahanty, and R. Kolter . 1990. Genetic analysis

Synthesis and the crystal and molecular structures of (H3L . Cl)[CoCl4] and H2L[CuBr4] (L is 2,4,6-Tri(N,N-dimethylamino)methylphenol)

International Nuclear Information System (INIS)

Kovalchukova, O. V.; Stash, A. I.; Strashnova, S. B.; Romashkina, E. P.; Zaitsev, B. E.

2010-01-01

The complex compounds (H 3 L . Cl)[CoCl 4 ] (I) and H 2 L[CuBr 4 ] (II), where L is 2,4,6-tri(N,N-dimethylamino)methylphenol, were isolated in the crystalline state and studied by X-ray diffraction. The organic cations were found to be outer-sphere ligands. All three nitrogen atoms of the tertiary amino groups are protonated. In compound I, the H 3 L 3+ cation exists as the cis tautomer. In compound II, the H 2 L 2+ dication exists as the trans isomer. In the crystal structure, the dications are arranged in layers via hydrogen bonds.

History of the 4950th Test Group (N)

Science.gov (United States)

1957-10-15

57, ~ ~ 1 3 . 1 Concept of Air Tamk htp fOg20tl~m BPgp0-n Operation MPDTACT. 33. &el. 7r EXIHIEO Pirul Report b u r a t r , p. 2. 9. 8.0 pp...end t h a t t h i s headquarters would take no action which could be interpreted as attempting t o establish such policy. Consequently, this...ing supplies, PX and sales stores. a. Units of Task Groun 7.4 w i l l receive suppliee in accordance with procedures outlined in Air Foroe Manual

Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability.

Science.gov (United States)

Tongsook, Chanakan; Niederhauser, Johannes; Kronegger, Elena; Straganz, Grit; Macheroux, Peter

2017-01-01

The degradation of histamine catalyzed by the SAM-dependent histamine N-methyltransferase (HNMT) is critically important for the maintenance of neurological processes. Recently, two mutations in the encoding human gene were reported to give rise to dysfunctional protein variants (G60D and L208P) leading to intellectual disability. In the present study, we have expressed eight L208 variants with either apolar (L208F and L208V), polar (L208N and L208T) or charged (L208D, L208H, L208K and L208R) amino acids to define the impact of side chain variations on protein structure and function. We found that the variants L208N, L208T, L208D and L208H were severely compromised in their stability. The other four variants were obtained in lower amounts in the order wild-type HNMT>L208F=L208V>L208K=L208R. Biochemical characterization of the two variants L208F and L208V exhibited similar Michaelis-Menten parameters for SAM and histamine while the enzymatic activity was reduced to 21% and 48%, respectively. A substantial loss of enzymatic activity and binding affinity for histamine was seen for the L208K and L208R variants. Similarly the thermal stability for the latter variants was reduced by 8 and 13°C, respectively. These findings demonstrate that position 208 is extremely sensitive to side chain variations and even conservative replacements affect enzymatic function. Molecular dynamics simulations showed that amino acid replacements in position 208 perturb the helical character and disrupt interactions with the adjacent β-strand, which is involved in the binding and correct positioning of histamine. This finding rationalizes the gradual loss of enzymatic activity observed in the L208 variants. Copyright © 2016 The Author(s). Published by Elsevier B.V. All rights reserved.

Copolymers based on N-acryloyl-L-leucine and urea methacrylate with pyridine moieties

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Buruiana Emil C.

2016-01-01

Full Text Available By using free radical polymerization of (N-methacryloyloxyethyl-N′-4-picolyl-urea (MAcPU and N-acryloyl-L-leucine (AcLeu, an optically active copolymer, poly[(N-methacryloyloxyethyl-N′-4-picolyl-urea-co-N-acryloyl-L-leucine], MAcPU-co-AcLeu (1.86:1 molar ratio was prepared and subsequently functionalized at the pyridine-N with (1R/S-(−/+-10-camphorsulfonic acid (R/S-CSA and at carboxyl group with (R-(+-α-ethylbenzylamine (R-EBA or trans-4-stilbene methanol (t-StM. The structures, chemical composition and chiroptical activity of the monomers and the copolymers were characterized by spectral analysis (FTIR, 1H (13C-NMR, 1H,1H-COSY, UV/vis, thermal methods (TGA, DSC, fluorescence spectroscopy, gel permeation chromatography and specific rotation measurements. Influence of the optical activity of monomer and modifier on modified copolymers suggested a good correlation between the experimental data obtained (23[α]589=+12.5° for AcLeu and MAcPU-co-AcLeu, 23[α]589=0°+27.5° for (MAcPU-co-AcLeu-R/S-CSA, 23[α]589=+25° for (MAcPU-co-AcLeu-R-EBA, and 23[α]589 = 0° for (MAcPU-co-AcLeu-St. In addition, the photobehavior of the stilbene copolymer (MAcPU-co-AcLeu-St in film was investigated by UV-vis spectroscopy. The fluorescence quenching of the stilbene species in the presence of aliphatic/aromatic amine in DMF solution was evaluated, more efficiently being 4,4′−dipyridyl (detection limit: 7.2 x 10-6 mol/L.

Milföy Hamurunun Isıl Yayınım Katsayısının Sıcaklıkla Değişiminin Belirlenmesi

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Seher Kumcuoğlu

2015-02-01

Full Text Available Bu çalışmada milföy hamurunun ısıl yayınım katsayısı modifiye edilmiş Dickerson metodu kullanılarak -35 °C ile +10 °C sıcaklık aralığında deneysel olarak ölçülmüştür. Örneğin donmuş durumdaki ısıl yayınım katsayısının donmamış durumuna ait ısıl yayınım katsayısından daha yüksek olduğu ve sıcaklığın artmasıyla azaldığı tespit edilmiştir. Donmuş durum için elde edilen ölçüm sonuçlarına regresyon analizi uygulanarak milföy hamurunun ısıl yayınım katsayısının sıcaklıkla değişimini veren empirik denklem elde edilmiştir. Donmamış durumda, 3-10 °C sıcaklık aralığında örneğin ısıl yayınım katsayısı 1.08 x 10-7 m²/s olarak ölçülmüştür.

Angiomyolipome rénal bilatéral et hémorragique: A propos d\\'un cas ...

African Journals Online (AJOL)

Un mois après, devant la récidive d\\'une hématurie massive avec état de choc hémorragique clinique et biologique, une néphrectomie droite d\\'hémostase était réalisée. L\\'évolution a été favorable et le recul actuel est de 24 mois. Keywords: Angiomyolipome, sclérose tubéreuse de Bourneville, embolisation artérielle ...

Identificación y comparación de síntomas de desgaste físico y mental en árbitros, entrenadores y educadores físicos

Directory of Open Access Journals (Sweden)

José Luis Prendas

2007-12-01

Full Text Available El propósito del estudio fue identificar y comparar los síntomas de desgaste físico y mental en árbitros y jueces deportivos, entrenadores deportivos y profesores (as de educación física. Se trabajó con un total de 44 sujetos (37,93±11,58 años de edad, de los cuales 14 eran entrenadores, 15 profesores (as de educación física y 15 árbitros o jueces deportivos. A todos los sujetos se les aplicó cuatro instrumentos: Perfil de Estados de ánimo (POMS, Cuestionario de Síntomas de Sobreentrenamiento (CSSE y Medida de Burnout (MB y una entrevista diseñada por los investigadores. Los resultados del estudio mostraron que un 25% de los sujetos estaba en situación de riesgo (3 entrenadores, 5 educadores, 3 árbitros y un 4,5% (1 entrenador y 1 árbitro tenían manifestaciones del burnout. Además, se encontró correlaciones significativas entre cuatro estados de ánimo (depresión, hostilidad, tensión y fatiga, tres síntomas de sobreentrenamiento (fatiga generalizada, disminución de la conducta y deseo sexual y alteraciones musculares y falta de apoyo social e irritabilidad y el puntaje de la Escala de Burnout. Mediante análisis de x2, se mostró que no había relación significativa (x2 =0,169; p>0,05 entre el rol y el riesgo de sufrir burnout. Esto se confirmó mediante regresión logística donde se observó que la posibilidad de estar en riesgo o de sufrir el síndrome de burnout eran similares para los tres roles examinados (1,12 veces si se era entrenador; 1,25 veces si se era árbitro y 0,7 veces si se era profesor de educación física. Mediante análisis de varianza se encontró diferencia significativa según el nivel de riesgo en cuatro estados anímicos (depresión, hostilidad, tensión y fatiga y cuatro síntomas de sobre entrenamiento (fatiga generalizada, falta de apoyo social e irritabilidad, deseo de asilamiento y negativismo y disminución de rendimiento. Los sujetos con riesgo o con burnout, tuvieron puntajes promedio

Images of the plant kingdom in the Mamluk encyclopedia Masālik al-abṣār by Ibn Faḍl Allāh al-‘Umarī (d. 1349)

OpenAIRE

Francesca Bellino

2016-01-01

This article aims at analyzing the representation of the plant kingdom in the Masālik al-abṣār fī mamālik al-amṣār, an Arabic encyclopaedia written by one the leading scholar of the Mamluk period, Šihāb al-Dīn Ibn Faḍl Allāh al-‘Umarī (1301-1349). The first part of the article offers an insight into the work of al-‘Umarī by presenting it in the framework of the encyclopaedic activities that characterize the fourteenth century. It also analyzes a number of special features of the Masālik al-ab...

Temporal dynamics of cortical and subcortical responses to apomorphine in Parkinson disease: an H2(15)O PET study

NARCIS (Netherlands)

Hosey, Lara A.; Thompson, Jennifer L. W.; Metman, Leonard Verhagen; van den Munckhof, Pepyn; Braun, Allen R.

2005-01-01

H2(15)O positron emission tomography (PET) was used to study the temporal course of central nervous system (CNS) responses to apomorphine in patients with idiopathic Parkinson disease (PD). Agonist-induced changes in regional cerebral blood flow (rCBF) were evaluated within

PSEN1 L226F mutation in a patient with early-onset Alzheimer’s disease in Korea

Directory of Open Access Journals (Sweden)

Bagyinszky E

2016-10-01

Full Text Available Eva Bagyinszky,1,* Sun Ah Park,2,* Hyung Jun Kim,2 Seong Hye Choi,3 Seong Soo A An,1 SangYun Kim4 1Department of BioNano Technology, Gachon University, Seongnam-si, 2Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, 3Department of Neurology, Inha University School of Medicine, Incheon, 4Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea *These authors contributed equally to this work Abstract: In this study, we report a first 226leucine (Leu mutation to phenylalanine (Phe in (PSEN1, CTC>TTC, L226F in Asia from a Korean early-onset Alzheimer’s disease (EOAD patient. Polymerase chain reaction (PCR–single strand conformation polymorphism, sequencing, and in silico predictions were performed. Previously, L226F was reported in EOAD patients by Zekanowski et al and Gómez-Tortosa et al. Disease phenotypes appeared in their thirties, and family history was positive in both cases. In our patient, age of onset was similar (37 years of age, but the mutation seemed to be de novo, since no affected family member was found. This leucine to phenylalanine substitution may cause additional stresses inside the transmembrane region due to large aromatic side chain and increased hydrophobic interactions with hydrocarbon chains in the membrane and its binding partners. Clinical phenotype of the mutation was aggressive progression into neurodegeneration, resulting in rapid cognitive decline. One of the patients was initially diagnosed with frontotemporal dementia, but the diagnosis was revised to AD upon postmortem studies in which Aβ plaques were seen. A second mutation, L226R, was found for the L226 residue. Similar to L226F, the patient with L226R also developed the first symptoms in his 30s, but EOAD was diagnosed in his 40s. These findings suggested that L226 might be an important residue in PSEN1

Les pneumopathies nosocomiales en réanimation de CHU Hassan II de Fès

Science.gov (United States)

Shimi, Abdelkarim; Touzani, Soumaya; Elbakouri, Nabil; Bechri, Brahim; Derkaoui, Ali; Khatouf, Mohammed

2015-01-01

L'objectif principal de notre étude était d'identifier les bactéries incriminées dans la pneumopathie nosocomiale (PN) au service de réanimation A1 du CHU Hassan II de Fès, en vue d'en améliorer la prise en charge et de diminuer la morbi-mortalité associée. Il s'agit d'une étude rétrospective et descriptive, menée du 1er janvier 2012 au 31 décembre 2013. Seules les infections pulmonaires survenant au-delà de 48 heures de l'admission du patient au service de réanimation ont été incluses. L'incidence de la PN était de 11,2%. Les Bacilles à Gram négatif (BGN) étaient retrouvés dans 48,5% des cas, le Staphylocoque Aureus dans 21,21% des cas et le Klebsiella Pneumoniae était dans 10,7% des cas. Le taux de mortalité était de 48,33%. L’âge, la gravité de la pathologie sous jacente et le retard de l'instauration d'une antibiothérapie adaptée étaient considérées comme facteurs de mauvais pronostic. L’étude de la résistance aux antibiotiques, montre une multirésistance surtout pour les BGN, dont il faut tenir compte en mettant en place une stratégie de prévention active. PMID:26966481

Energy Transfer between Post-Transition Elements & Rare Earths in Oxide & Chalcogenide Glasses.

Science.gov (United States)

1979-08-27

Caird [13]. A calculation of reduced matrix elements of Pr3 in 20 Na O • 80 TeO2 glass [14] showed that they differ slightly from data of ref. [121... glasses Transition (lass 35 ZnO 65 TeO2 20 Na2 O 80 TeO 2 fX 106 fX 106 l.,eas 3a, a) Ia’l. faI f.me.s f al f+ I fal 3 H4 - 3 H6 1.56 1.65 1.12...Rare-Earth Doped Glasses 20. jIST HAEV CCnFn~m ,i cn,on ra e sideit If c."*Ar’ -- ~ 14-r by t?-h.c .: r Intensity parameters, radiative transition