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Sample records for r process

  1. Reaction Sensitivity of r-Process Nucleosynthesis

    CERN Document Server

    Sasaqui, T; Mathews, G J; Otsuki, K; Nakamura, K; Sasaqui, Taka.

    2005-01-01

    We study the efficiency and sensitivity of r-process nucleosynthesis to a number of light nuclear reaction rates. We adopt empirical power-law relations to parameterize the reaction sensitivities. We utilize two different hydrodynamic models for the neutrino-driven winds in order to study the dependence of our result on supernova wind models. We also utilize an exponential model to approximate a wide variety of other plausible conditions for the r-process. We identify several specific nuclear reactions among light neutron-rich nuclei that play a critical role in determining the final r-process nucleosynthesis yields. As an illustration, we examine ``semi-waing'' points among the carbon isotopes. We show that not only neutron capture and $\\beta$-decay, but also $(\\alpha, \\mathrm{n})$ reactions are important in determining waiting points along the r-process path. Our numerical results from this sensitivity analysis serve foremost to clarify which light nuclear reactions are most influential in determining the f...

  2. THE r-PROCESS IN MAGNETOROTATIONAL SUPERNOVAE

    Energy Technology Data Exchange (ETDEWEB)

    Tsujimoto, Takuji [National Astronomical Observatory of Japan, Mitaka-shi, Tokyo 181-8588 (Japan); Nishimura, Nobuya, E-mail: taku.tsujimoto@nao.ac.jp [Astrophysics Group, Keele University, ST5 5BG Keele (United Kingdom)

    2015-09-20

    One of the hottest open issues involving the chemical evolution of r-process elements is fast enrichment in the early universe. Clear evidence for the chemical enrichement of r-process elements is seen in the stellar abundances of extremely metal poor stars in the Galactic halo. However, small-mass galaxies are the ideal testbed for studying the evolutionary features of r-process enrichment given the potential rarity of production events yielding heavy r-process elements. Their occurrences become countable and thus an enrichment path due to each event can be found in the stellar abundances. We examine the chemical feature of Eu abundance at an early stage of [Fe/H] ≲ −2 in the Draco and Sculptor dwarf spheroidal (dSph) galaxies. Accordingly, we constrain the properties of Eu production in the early dSphs. We find that the Draco dSph experienced a few Eu production events, whereas Eu enrichment took place more continuously in the Sculptor dSph due to its larger stellar mass. The event rate of Eu production is estimated to be about one per 100−200 core-collapse supernovae, and a Eu mass of ∼ (1–2) × 10{sup −5}M{sub ⊙} per single event is deduced by associating this frequency with the observed plateau value of [Eu/H] ∼ −1.3 for [Fe/H] ≳ −2. The observed plateau implies that early Eu enrichment ceases at [Fe/H] ≈ −2. Such a selective operation only in low-metallicity stars supports magnetorotational supernovae, which require very fast rotation, as the site of early Eu production. We show that the Eu yields deduced from chemical evolution agree well with the nucleosynthesis results from corresponding supernovae models.

  3. Primordial Black Holes and r -Process Nucleosynthesis

    Science.gov (United States)

    Fuller, George M.; Kusenko, Alexander; Takhistov, Volodymyr

    2017-08-01

    We show that some or all of the inventory of r -process nucleosynthesis can be produced in interactions of primordial black holes (PBHs) with neutron stars (NSs) if PBHs with masses 10-14 M⊙process and the accompanying decompression and decay of nuclear matter can produce electromagnetic transients, such as a kilonova-type afterglow and fast radio bursts. These transients are not accompanied by significant gravitational radiation or neutrinos, allowing such events to be differentiated from compact object mergers occurring within the distance sensitivity limits of gravitational-wave observatories. The PBH-NS destruction scenario is consistent with pulsar and NS statistics, the dark-matter content, and spatial distributions in the Galaxy and ultrafaint dwarfs, as well as with the r -process content and evolution histories in these sites. Ejected matter is heated by beta decay, which leads to emission of positrons in an amount consistent with the observed 511-keV line from the Galactic center.

  4. r-Process Enhanced Halo Stars

    CERN Document Server

    Cowan, J J; Lawler, J E; Den Hartog, E A

    2006-01-01

    Abundance observations indicate the presence of rapid-neutron capture (i.e., r-process) elements in old Galactic halo and globular cluster stars. These observations provide insight into the nature of the earliest generations of stars in the Galaxy -- the progenitors of the halo stars -- responsible for neutron-capture synthesis of the heavy elements. The large star-to-star scatter observed in the abundances of neutron-capture element/iron ratios at low metallicities -- which diminishes with increasing metallicity or [Fe/H] -- suggests the formation of these heavy elements (presumably from certain types of supernovae) was rare in the early Galaxy. The stellar abundances also indicate a change from the r-process to the slow neutron capture (i.e., s-) process at higher metallicities in the Galaxy and provide insight into Galactic chemical evolution. Finally, the detection of thorium and uranium in halo and globular cluster stars offers an independent age-dating technique that can put lower limits on the age of t...

  5. The alpha -Process and the r-Process

    Science.gov (United States)

    Woosley, S. E.; Hoffman, R. D.

    1992-12-01

    If material initially in nuclear statistical equilibrium (NSE) at high temperature and containing a large fraction of alpha -particles (or nucleons) is expanded and cooled so rapidly that not all the alpha -particles have time to reassemble, its final composition will differ substantially from what is traditionally calculated for particle-deficient freeze-outs. It has long been known that this phenomenon, the ``alpha -rich freeze-out," can lead to the production of elements heavier than the iron group, but only up to about zinc (A ~ 66). Here we explore the alpha -rich freeze-out for values of neutron excess larger than previously treated and discover nuclear systematics that, for neutron excesses greater than about 0.05, allow the creation of heavier elements all the way up to A ~ 100, even when most of the ejecta is in the form of heavy elements. In the limit of a very large fraction of unassembled alpha -particles and a large neutron excess, the alpha -rich freeze-out merges smoothly into the classical r-process. In contrast to previous studies, we find that a large part of the nuclear flow in the r-process may be carried by charged particle reactions up to about A = 100. We speculate that the site of these processes is the high entropy ``wind'' of a young (age 1-10 s) neutron star in which neutrino energy deposition is driving mass loss. The appropriate conditions exist in the delayed supernova explosion mechanism of Mayle & Wilson, but they may occur in other models as well. The mass of r-process ejected per supernova is expected to be ~ 10(-4) M\\sun \\ per Type II or Type Ib supernova, but this will be sensitive to details of the presupernova structure, the explosion mechanism, and the amount of material that falls back onto the neutron star when the reverse shock arrives there.

  6. New Observational Perspectives on r-process Nucleosynthesis

    Science.gov (United States)

    Roederer, Ian U.

    2012-10-01

    Elements heavier than the iron group can be found in nearly every star whose abundances have been studied in detail. More than 60 percent of the naturally-occurring elements between zinc and uranium have been detected in r-process enriched stars. Models of the r-process rely heavily on matching astronomical observations, so this is good news for studies of r-process nucleosynthesis. I will highlight some of what we've learned from three decades of studying r-process material in other stars, describe current efforts that use the Hubble Space Telescope to expand the chemical inventory in r-process environments beyond the Solar system, and note opportunities for complementary studies by the physics community.

  7. Introduction to image processing using R learning by examples

    CERN Document Server

    Frery, Alejandro C

    2013-01-01

    This book introduces the statistical software R to the image processing community in an intuitive and practical manner. R brings interesting statistical and graphical tools which are important and necessary for image processing techniques. Furthermore, it has been proved in the literature that R is among the most reliable, accurate and portable statistical software available. Both the theory and practice of R code concepts and techniques are presented and explained, and the reader is encouraged to try their own implementation to develop faster, optimized programs. Those who are new to the fiel

  8. Impact of nuclear fission on r-process nucleosynthesis and origin of solar r-process elements

    Energy Technology Data Exchange (ETDEWEB)

    Shibagaki, Shota, E-mail: shota.shibagaki@nao.ac.jp [Department of Astronomy, Graduate School of Science, University of Tokyo, 2 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan and National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 (Japan); Kajino, Toshitaka [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588, Japan and Department of Astronomy, Graduate School of Science, University of Tokyo, 2 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Mathews, Grant J. [Center for Astrophysics, Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States); Chiba, Satoshi [Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, 152-8850 (Japan)

    2015-02-24

    Binary neutron star mergers (NSMs) are expected to be main production sites of r-process elements. Their ejecta are extremely neutron-rich (Y{sub e}<0.1), and the r-process path proceeds along the neutron drip line and enters the region of fissile nuclei. In this situation, although superheavy nuclei may be synthesized and the r-process path may reach the island of stability, those are sensitive to theoretical models of nuclear masses and nuclear fission. In this study, we carry out r-process nucleosynthesis simulations in the NSMs. Our new nuclear reaction network code include new theoretical models of nuclear masses and nuclear fission. Our r-process simulation of a binary NSM shows that the final r-process elemental abundances exhibit flat pattern for A∼110-160, and several fission cycling operate in extremely neutron-rich conditions of the NSM. We find that the combination of the NSMs and the magnetorotational supernovae can reproduce the solar r-process elements. We discuss the validity of this interpretation.

  9. Galactic r-process production: The inhomogeneous approach

    CERN Document Server

    Wehmeyer, B; Thielemann, F -K

    2015-01-01

    The origin of elements made by the rapid neutron-capture process (r-process) is not fully understood. Different sources have been proposed, e.g., core-collapse supernovae and neutron star mergers. Old metal-poor stars carry the signature of the astrophysical r-process source(s). Europium is the most indicative element to trace the r-process production, since it is mostly made by the r-process and it is easy to observe compared to other heavy r-process elements. In this work we simulate the evolution of europium in our Galaxy with the inhomogeneous chemical evolution model ICE, and we compare our results with spectroscopic observations. We test the most important parameters affecting the chemical evolution of the r-process element Eu: (a) for neutron star mergers the coalescence time scale of the merger and the probability to experience a neutron star merger event after two supernova explosions occurred and formed a double neutron star system ) and (b) for the sub-class of magneto-rotationally driven Supernova...

  10. Impact of nuclear mass uncertainties on the $r$-process

    CERN Document Server

    Martin, Dirk; Nazarewicz, Witold; Olsen, Erik

    2015-01-01

    Nuclear masses play a fundamental role in understanding how the heaviest elements in the Universe are created in the $r$-process. We predict $r$-process nucleosynthesis yields using neutron capture and photodissociation rates that are based on nuclear density functional theory. Using six Skyrme energy density functionals based on different optimization protocols, we determine for the first time systematic uncertainty bands -- related to mass modeling -- for $r$-process abundances in realistic astrophysical scenarios. We find that features of the underlying microphysics make an imprint on abundances especially in the vicinity of neutron shell closures: abundance peaks and troughs are reflected in trends of neutron separation energy. Further advances in nuclear theory and experiments, when linked to observations, will help in the understanding of astrophysical conditions in extreme $r$-process sites.

  11. Monte Carlo calculations for r-process nucleosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Mumpower, Matthew Ryan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-11-12

    A Monte Carlo framework is developed for exploring the impact of nuclear model uncertainties on the formation of the heavy elements. Mass measurements tightly constrain the macroscopic sector of FRDM2012. For r-process nucleosynthesis, it is necessary to understand the microscopic physics of the nuclear model employed. A combined approach of measurements and a deeper understanding of the microphysics is thus warranted to elucidate the site of the r-process.

  12. Recent Progress in the Understanding of the r-Process

    CERN Document Server

    Qian, Yong-Zhong

    2008-01-01

    A brief overview of the r-process is given with an emphasis on the observational implications for this process. The conditions required for the major production of the heavy r-process elements (r-elements) with mass numbers A >130 are discussed based on a generic astrophysical model where matter adiabatically expands from a hot and dense initial state. Nucleosynthesis in the neutrino-driven winds from nascent neutron stars is discussed as a specific example. Such winds readily produce the elements from Sr to Ag with A ~ 88 to 110 through charged-particle reactions in the alpha-process but appear incapable of making the heavy r-elements. Observations of elemental abundances in metal-poor stars have provided many valuable insights into the r-process. They have demonstrated that the production of the heavy r-elements must be associated with massive stars evolving on short timescales, provided evidence strongly favoring core-collapse supernovae over neutron star mergers as the major source for these elements, and...

  13. Where, oh where has the r-process gone?

    Energy Technology Data Exchange (ETDEWEB)

    Qian, Y.-Z. [School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455 (United States)]. E-mail: qian@physics.umn.edu; Wasserburg, G.J. [Lunatic Asylum, Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125 (United States)]. E-mail: gjw@gps.caltech.edu

    2007-04-15

    We present a review of the possible sources for r-process nuclei (r-nuclei). It is known that there is as yet no self-consistent mechanism to provide abundant neutrons for a robust r-process in the neutrino-driven winds from nascent neutron stars. We consider that the heavy r-nuclei with mass numbers A>130 (Ba and above) cannot be produced in the neutrino-driven winds. Nonetheless, the r-process and the neutrino-driven winds may be directly or indirectly related by some unknown additional mechanism, which, for example, could provide ejecta with very short dynamic timescales of < or approx 0.004s. This undetermined mechanism must supply a neutron source within the same general stellar sites that undergo core collapse to produce the neutron star. Observational data on low-metallicity stars in the Galactic halo show that sites producing the heavy r-nuclei do not produce Fe or any other elements between N and Ge. Insofar as a forming neutron star is key to producing the heavy r-nuclei, then the only possible sources are supernovae resulting from collapse of O-Ne-Mg cores or accretion-induced collapse of white dwarfs, neither of which produce the elements of the Fe group or those of intermediate mass (above C and N). Observational evidence on s and r-nuclei in low-metallicity stars with high C and N abundances shows that the r-process is also active in binary systems. The nuclei with A{approx}90-110 produced by charged-particle reactions (CPR) in the neutrino-driven winds are in general present in metal-poor stars with high or low abundances of heavy r-nuclei. The CPR nuclei and the heavy r-nuclei are not strongly coupled. Some metal-poor stars show extremely high enrichments of heavy r-nuclei and have established that the abundance patterns of these nuclei are universally close to the solar abundance pattern of heavy r-nuclei. Using a template star with high enrichments of heavy r-nuclei and another with low enrichments we develop a two-component model based on the

  14. Nuclear structure studies for the astrophysical r-process

    CERN Document Server

    Pfeiffer, B; Thielemann, F K; Walters, W B

    2001-01-01

    The production of the heaviest elements in nature occurs via the r-process, i.e. a combination of rapid neutron captures, the inverse photodisintegrations, and slower beta sup - -decays, beta-delayed processes as well as fission and possibly interactions with intense neutrino fluxes. A correct understanding and modeling requires the knowledge of nuclear properties far from stability and a detailed prescription of the astrophysical environment. Experiments at radioactive ion beam facilities have played a pioneering role in exploring the characteristics of nuclear structure in terms of masses and beta-decay properties. Initial examinations paid attention to highly unstable nuclei with magic neutron numbers and their beta-decay properties, related to the location and height of r-process peaks, while recent activities focus on the evolution of shell effects at large distances from the valley of stability. We show in site-independent applications the effect of both types of nuclear properties on r-process abundanc...

  15. Patterning of organic photovoltaic on R2R processed thin film barriers using IR laser sources

    NARCIS (Netherlands)

    Fledderus, H.; Akkerman, H.B.; Salem, A.; Friedrich Schilling, N.; Klotzbach, U.

    2017-01-01

    We present the development of laser processes for flexible OPV on roll-to-roll (RR2R) produced thin film barrier with indium tin oxide (ITO) as transparent conductive (TC) bottom electrode. Direct laser structuring of ITO on such barrier films (so-called P1 process) is very challenging since the

  16. Practical evaluation of organic polymer thermoelectrics by large-area R2R processing on flexible substrates

    DEFF Research Database (Denmark)

    Søndergaard, Roar R.; Hösel, Markus; Espinosa Martinez, Nieves

    2013-01-01

    Here, we present a process based on roll-to-roll (R2R) technology which allows for very fast processing of polymer thermoelectric (TE) devices and we furthermore demonstrate a simplified but more efficient way of serially connecting these devices by means of R2R thin-film processing. The new device...

  17. Rosen's (M,R) system in process algebra.

    Science.gov (United States)

    Gatherer, Derek; Galpin, Vashti

    2013-11-17

    Robert Rosen's Metabolism-Replacement, or (M,R), system can be represented as a compact network structure with a single source and three products derived from that source in three consecutive reactions. (M,R) has been claimed to be non-reducible to its components and algorithmically non-computable, in the sense of not being evaluable as a function by a Turing machine. If (M,R)-like structures are present in real biological networks, this suggests that many biological networks will be non-computable, with implications for those branches of systems biology that rely on in silico modelling for predictive purposes. We instantiate (M,R) using the process algebra Bio-PEPA, and discuss the extent to which our model represents a true realization of (M,R). We observe that under some starting conditions and parameter values, stable states can be achieved. Although formal demonstration of algorithmic computability remains elusive for (M,R), we discuss the extent to which our Bio-PEPA representation of (M,R) allows us to sidestep Rosen's fundamental objections to computational systems biology. We argue that the behaviour of (M,R) in Bio-PEPA shows life-like properties.

  18. Rosen’s (M,R) system in process algebra

    Science.gov (United States)

    2013-01-01

    Background Robert Rosen’s Metabolism-Replacement, or (M,R), system can be represented as a compact network structure with a single source and three products derived from that source in three consecutive reactions. (M,R) has been claimed to be non-reducible to its components and algorithmically non-computable, in the sense of not being evaluable as a function by a Turing machine. If (M,R)-like structures are present in real biological networks, this suggests that many biological networks will be non-computable, with implications for those branches of systems biology that rely on in silico modelling for predictive purposes. Results We instantiate (M,R) using the process algebra Bio-PEPA, and discuss the extent to which our model represents a true realization of (M,R). We observe that under some starting conditions and parameter values, stable states can be achieved. Although formal demonstration of algorithmic computability remains elusive for (M,R), we discuss the extent to which our Bio-PEPA representation of (M,R) allows us to sidestep Rosen’s fundamental objections to computational systems biology. Conclusions We argue that the behaviour of (M,R) in Bio-PEPA shows life-like properties. PMID:24237684

  19. On the R-Process Enrichment of Dwarf Spheroidal Galaxies

    CERN Document Server

    Bramante, Joseph

    2016-01-01

    Recent observations of Reticulum II have uncovered an overabundance of r-process elements, compared to similar ultra-faint dwarf spheroidal galaxies (UFDs). Because the metallicity and star formation history of Reticulum II appear consistent with all known UFDs, the high r-process abundance of Reticulum II suggests enrichment through a single, rare event, such as a double neutron star (NS) merger. However, we note that this scenario is extremely unlikely, as binary stellar evolution models require significant supernova natal kicks to produce NS-NS or NS-black hole mergers, and these kicks would efficiently remove compact binary systems from the weak gravitational potentials of UFDs. We examine alternative mechanisms for the production of r-process elements in UFDs, including a novel mechanism wherein NSs in regions of high dark matter density implode after accumulating a black-hole-forming mass of dark matter. We find that r-process proto-material ejection by tidal forces, when a single neutron star implodes ...

  20. ACToR Chemical Structure processing using Open Source ...

    Science.gov (United States)

    ACToR (Aggregated Computational Toxicology Resource) is a centralized database repository developed by the National Center for Computational Toxicology (NCCT) at the U.S. Environmental Protection Agency (EPA). Free and open source tools were used to compile toxicity data from over 1,950 public sources. ACToR contains chemical structure information and toxicological data for over 558,000 unique chemicals. The database primarily includes data from NCCT research programs, in vivo toxicity data from ToxRef, human exposure data from ExpoCast, high-throughput screening data from ToxCast and high quality chemical structure information from the EPA DSSTox program. The DSSTox database is a chemical structure inventory for the NCCT programs and currently has about 16,000 unique structures. Included are also data from PubChem, ChemSpider, USDA, FDA, NIH and several other public data sources. ACToR has been a resource to various international and national research groups. Most of our recent efforts on ACToR are focused on improving the structural identifiers and Physico-Chemical properties of the chemicals in the database. Organizing this huge collection of data and improving the chemical structure quality of the database has posed some major challenges. Workflows have been developed to process structures, calculate chemical properties and identify relationships between CAS numbers. The Structure processing workflow integrates web services (PubChem and NIH NCI Cactus) to d

  1. The p- and r-processes reviews and other views

    CERN Document Server

    Arnould, M; Rayet, M

    2001-01-01

    A review is presented of the p-process in Type II supernovae, one of its goals being to enlighten the changes in views on this nucleosynthesis mechanism since the work of Jean and Jim on the subject in 1975. Specific discussions are also devoted to cases of particular interest, like the light Mo and Ru stable isotopes, the rare nuclide 138La or the radionuclide 146Sm. Some comments of diverse natures are also made on the r-process. These considerations do not aim at really providing an exhaustive review of the many nuclear physics and astrophysics intricacies of this process. In contrast, they are hoped to complement or to put in perspective other views that are often expressed in relation with this nucleosynthesis mechanism

  2. The p- and r- processes: reviews and other views

    Science.gov (United States)

    Arnould, M.; Goriely, S.; Rayet, M.

    A review is presented of the p-process in Type II supernovae, one of its goals being to enlighten the changes in views on this nucleosynthesis mechanism since the work of Jean and Jim on the subject in 1975. Specific discussions are also devoted to cases of particular interest, like the light Mo and Ru stable isotopes, the rare nuclide 138La or the radionuclide 146Sm. Some comments of diverse natures are also made on the r-process. These considerations do not aim at really providing an exhaustive review of the many nuclear physics and astrophysics intricacies of this process. In contrast, they are hoped to complement or to put in perspective other views that are often expressed in relation with this nucleosynthesis mechanism

  3. Cerebellar rTMS disrupts predictive language processing

    Science.gov (United States)

    Lesage, Elise; Morgan, Blaire E.; Olson, Andrew C.; Meyer, Antje S.; Miall, R. Chris

    2012-01-01

    Summary The human cerebellum plays an important role in language, amongst other cognitive and motor functions [1], but a unifying theoretical framework about cerebellar language function is lacking. In an established model of motor control, the cerebellum is seen as a predictive machine, making short-term estimations about the outcome of motor commands. This allows for flexible control, on-line correction, and coordination of movements [2]. The homogeneous cytoarchitecture of the cerebellar cortex suggests that similar computations occur throughout the structure, operating on different input signals and with different output targets [3]. Several authors have therefore argued that this ‘motor’ model may extend to cerebellar nonmotor functions [3–5], and that the cerebellum may support prediction in language processing [6]. However, this hypothesis has never been directly tested. Here, we used the ‘Visual World’ paradigm [7], where on-line processing of spoken sentence content can be assessed by recording the latencies of listeners' eye movements towards objects mentioned. Repetitive transcranial magnetic stimulation (rTMS) was used to disrupt function in the right cerebellum, a region implicated in language [8]. After cerebellar rTMS, listeners showed delayed eye fixations to target objects predicted by sentence content, while there was no effect on eye fixations in sentences without predictable content. The prediction deficit was absent in two control groups. Our findings support the hypothesis that computational operations performed by the cerebellum may support prediction during both motor control and language processing. PMID:23017990

  4. The Langevin Approach: An R Package for Modeling Markov Processes

    Directory of Open Access Journals (Sweden)

    Philip Rinn

    2016-08-01

    Full Text Available We describe an 'R' package developed by the research group 'Turbulence, Wind energy' 'and Stochastics' (TWiSt at the Carl von Ossietzky University of Oldenburg, which extracts the (stochastic evolution equation underlying a set of data or measurements. The method can be directly applied to data sets with one or two stochastic variables. Examples for the one-dimensional and two-dimensional cases are provided. This framework is valid under a small set of conditions which are explicitly presented and which imply simple preliminary test procedures to the data. For Markovian processes involving Gaussian white noise, a stochastic differential equation is derived straightforwardly from the time series and captures the full dynamical properties of the underlying process. Still, even in the case such conditions are not fulfilled, there are alternative versions of this method which we discuss briefly and provide the user with the necessary bibliography.

  5. The Langevin Approach: An R Package for Modeling Markov Processes

    CERN Document Server

    Rinn, Philip; Wächter, Matthias; Peinke, Joachim

    2016-01-01

    We describe an R package developed by the research group Turbulence, Wind energy and Stochastics (TWiSt) at the Carl von Ossietzky University of Oldenburg, which extracts the (stochastic) evolution equation underlying a set of data or measurements. The method can be directly applied to data sets with one or two stochastic variables. Examples for the one-dimensional and two-dimensional cases are provided. This framework is valid under a small set of conditions which are explicitly presented and which imply simple preliminary test procedures to the data. For Markovian processes involving Gaussian white noise, a stochastic differential equation is derived straightforwardly from the time series and captures the full dynamical properties of the underlying process. Still, even in the case such conditions are not fulfilled, there are alternative versions of this method which we discuss briefly and provide the user with the necessary bibliography.

  6. Magnetic Protoneutron Star Winds and r-Process Nucleosynthesis

    CERN Document Server

    Thompson, T A

    2003-01-01

    Because of their neutron-richness and association with supernovae, post-explosion protoneutron star winds are thought to be a likely astrophysical site for rapid neutron capture nucleosynthesis (the r-process). However, the most recent models of spherical neutrino-driven protoneutron star winds do not produce robust r-process nucleosynthesis for `canonical' neutron stars with a gravitational mass of 1.4M_sun and coordinate radius of 10km. These models fail variously; either the flow entropy is too low, the electron fraction is too high, or the dynamical expansion timescale is too long. To date, no models have included the effects of an ordered dipole magnetic field. We show that a strong magnetic field can trap the outflow in the neutrino heating region, thus leading to much higher matter entropy. We estimate both the trapping timescale and the resulting entropy amplification. For sufficiently large energy deposition rates, the trapped matter emerges dynamically from the region of closed magnetic field lines ...

  7. r-Process Lanthanide Production and Heating Rates in Kilonovae

    CERN Document Server

    Lippuner, Jonas

    2015-01-01

    r-Process nucleosynthesis in material ejected during neutron star mergers may lead to radioactively powered transients called kilonovae. The timescale and peak luminosity of these transients depend on the composition of the material after nuclear burning ceases, which determines the local heating rate from nuclear decays and the opacity. Kasen et al. (2013, ApJ, 774, 25) and Tanaka & Hotokezaka (2013, ApJ, 775, 113) pointed out that lanthanides can drastically increase the opacity in these outflows. We use the new general-purpose nuclear reaction network SkyNet to carry out a parameter study of r-process nucleosynthesis for a range of initial electron fractions $Y_e$, initial specific entropies $s$, and expansion timescales $\\tau$. We find that the ejecta is lanthanide-free for $Y_e \\gtrsim 0.22 - 0.30$, depending on $s$ and $\\tau$. The heating rate is insensitive to $s$ and $\\tau$, but certain, larger values of $Y_e$ lead to reduced heating rates, due to individual nuclides dominating the heating. With a...

  8. Data Processing Languages for Business Intelligence. SQL vs. R

    Directory of Open Access Journals (Sweden)

    Marin FOTACHE

    2016-01-01

    Full Text Available As data centric approach, Business Intelligence (BI deals with the storage, integration, processing, exploration and analysis of information gathered from multiple sources in various formats and volumes. BI systems are generally synonymous to costly, complex platforms that require vast organizational resources. But there is also an-other face of BI, that of a pool of data sources, applications, services developed at different times using different technologies. This is “democratic” BI or, in some cases, “fragmented”, “patched” (or “chaotic” BI. Fragmentation creates not only integration problems, but also supports BI agility as new modules can be quickly developed. Among various languages and tools that cover large extents of BI activities, SQL and R are instrumental for both BI platform developers and BI users. SQL and R address both monolithic and democratic BI. This paper compares essential data processing features of two languages, identifying similarities and differences among them and also their strengths and limits.

  9. MDRL lncRNA regulates the processing of miR-484 primary transcript by targeting miR-361.

    Directory of Open Access Journals (Sweden)

    Kun Wang

    2014-07-01

    Full Text Available Long noncoding RNAs (lncRNAs are emerging as new players in gene regulation, but whether lncRNAs operate in the processing of miRNA primary transcript is unclear. Also, whether lncRNAs are involved in the regulation of the mitochondrial network remains to be elucidated. Here, we report that a long noncoding RNA, named mitochondrial dynamic related lncRNA (MDRL, affects the processing of miR-484 primary transcript in nucleus and regulates the mitochondrial network by targeting miR-361 and miR-484. The results showed that miR-361 that predominantly located in nucleus can directly bind to primary transcript of miR-484 (pri-miR-484 and prevent its processing by Drosha into pre-miR-484. miR-361 is able to regulate mitochondrial fission and apoptosis by regulating miR-484 levels. In exploring the underlying molecular mechanism by which miR-361 is regulated, we identified MDRL and demonstrated that it could directly bind to miR-361 and downregulate its expression levels, which promotes the processing of pri-miR-484. MDRL inhibits mitochondrial fission and apoptosis by downregulating miR-361, which in turn relieves inhibition of miR-484 processing by miR-361. Our present study reveals a novel regulating model of mitochondrial fission program which is composed of MDRL, miR-361 and miR-484. Our work not only expands the function of the lncRNA pathway in gene regulation but also establishes a new mechanism for controlling miRNA expression.

  10. r-PROCESS LANTHANIDE PRODUCTION AND HEATING RATES IN KILONOVAE

    Energy Technology Data Exchange (ETDEWEB)

    Lippuner, Jonas; Roberts, Luke F., E-mail: jlippuner@tapir.caltech.edu [TAPIR, Walter Burke Institute for Theoretical Physics, California Institute of Technology, MC 350-17, 1200 E California Boulevard, Pasadena CA 91125 (United States)

    2015-12-20

    r-process nucleosynthesis in material ejected during neutron star mergers may lead to radioactively powered transients called kilonovae. The timescale and peak luminosity of these transients depend on the composition of the ejecta, which determines the local heating rate from nuclear decays and the opacity. Kasen et al. and Tanaka and Hotokezaka pointed out that lanthanides can drastically increase the opacity in these outflows. We use the new general-purpose nuclear reaction network SkyNet to carry out a parameter study of r-process nucleosynthesis for a range of initial electron fractions Y{sub e}, initial specific entropies s, and expansion timescales τ. We find that the ejecta is lanthanide-free for Y{sub e} ≳ 0.22−0.30, depending on s and τ. The heating rate is insensitive to s and τ, but certain, larger values of Y{sub e} lead to reduced heating rates, due to individual nuclides dominating the heating. We calculate approximate light curves with a simplified gray radiative transport scheme. The light curves peak at about a day (week) in the lanthanide-free (-rich) cases. The heating rate does not change much as the ejecta becomes lanthanide-free with increasing Y{sub e}, but the light-curve peak becomes about an order of magnitude brighter because it peaks much earlier when the heating rate is larger. We also provide parametric fits for the heating rates between 0.1 and 100 days, and we provide a simple fit in Y{sub e}, s, and τ to estimate whether or not the ejecta is lanthanide-rich.

  11. Oleic Acid Induces MiR-7 Processing through Remodeling of Pri-MiR-7/Protein Complex.

    Science.gov (United States)

    Kumar, Santosh; Downie Ruiz Velasco, Angela; Michlewski, Gracjan

    2017-06-02

    MicroRNAs (miRs) play a vital role in governing cell function, with their levels tightly controlled at transcriptional and post-transcriptional levels. Different sets of RNA-binding proteins interact with primary miRs (pri-miRs) and precursor-miR transcripts (pre-miRs), controlling their biogenesis post-transcriptionally. The Hu antigen R (HuR)-mediated binding of Musashi homolog2 (MSI2) to the conserved terminal loop of pri-miR-7 regulates the levels of brain-enriched miR-7 formation in a tissue-specific manner. Here, we show that oleic acid (OA) inhibits the binding of proteins containing RNA recognition motifs (RRM) to the conserved terminal loop of pri-miR-7. Using electrophoretic mobility shift assays in HeLa cell extracts, we show that OA treatment disrupts pre-miR/protein complexes. Furthermore, OA rescues in vitro processing of pri-miR-7, which is otherwise blocked by HuR and MSI2 proteins. On the contrary, pri-miR-16 shows reduced processing in the presence of OA. This indicates that OA may inhibit the binding of other RRM-containing protein/s necessary for miR-16 processing. Finally, we demonstrate that OA induces mature miR-7 production in HeLa cells. Together, our results demonstrate that OA can regulate the processing of pri-miRs by remodeling their protein complexes. This provides a new tool to study RNA processing and a potential lead for small molecules that target the miR-7 biogenesis pathway. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  12. PtProcess: An R Package for Modelling Marked Point Processes Indexed by Time

    Directory of Open Access Journals (Sweden)

    David Harte

    2010-10-01

    Full Text Available This paper describes the package PtProcess which uses the R statistical language. The package provides a unified approach to fitting and simulating a wide variety of temporal point process or temporal marked point process models. The models are specified by an intensity function which is conditional on the history of the process. The user needs to provide routines for calculating the conditional intensity function. Then the package enables one to carry out maximum likelihood fitting, goodness of fit testing, simulation and comparison of models. The package includes the routines for the conditional intensity functions for a variety of standard point process models. The package is intended to simplify the fitting of point process models indexed by time in much the same way as generalized linear model programs have simplified the fitting of various linear models. The primary examples used in this paper are earthquake sequences but the package is intended to have a much wider applicability.

  13. Nuclear structure theory for the astrophysical rp-process and r-process

    Energy Technology Data Exchange (ETDEWEB)

    Brown, B.A.; Clement, R.; Schatz, H.; Giansiracusa, J.; Richter, W.A.; Hjorth-Jensen, M.; Kratz, K.-L.; Pfeiffer, B.; Walters, W.B

    2003-05-19

    The astrophysical processes of rapid-proton capture and rapid-neutron capture require the knowledge of many nuclear properties which are not known from experiment. I will describe two examples of how theoretical models are used to provide this input. The first of these uses the Hartree-Fock method for displacement energies to obtain the masses of proton-rich nuclei needed for the rp-process. The second uses a model for configuration mixing near {sup 132}Sn to provide Q values and beta-decay lifetimes for the r-process.

  14. Analysis of nucleolar pre-rRNA processing sites in pea(Pisum sativum)

    Institute of Scientific and Technical Information of China (English)

    LONG; Hong; (龙; 鸿); ZENG; Xianlu; (曾宪录); JIAO; Mingda; (焦明大); HU; Bo; (胡; 波); SUN; Haijing; (孙海晶); LIU; Zhenlan; (刘振兰); ZHANG; Liyong; (张立勇); HAO; Shui; (郝; 水)

    2003-01-01

    The location of rRNA processing was analyzed by using in situ hybridization with ITS1 probe and immunolabeling of anti-fibrillarin mAb in pea (Pisum sativum) root pole cells. The results showed that rRNA processing sites were in dense fibrillar components (DFCs) and granular components (GCs), but not in fibrillar centers (FCs). Low doses of actinomycin D (AMD) treatment can selectively suppress pre-rRNA synthesis but cannot disturb the processing of preformed pre-rRNAs. With AMD treatment prolonged, the density of labeled signals gradually decreased, indicating the preformed pre-rRNAs were gradually processed.

  15. Helping science to succeed: improving processes in R&D.

    Science.gov (United States)

    Sewing, Andreas; Winchester, Toby; Carnell, Pauline; Hampton, David; Keighley, Wilma

    2008-03-01

    Bringing drugs to the market remains a costly and, until now, often unpredictable challenge. Although understanding the underlying science is key to further progress, our imperfect knowledge of disease and complex biological systems leaves excellence in execution as the most tangible lever to sustain our serendipitous approach to drug discovery. The problems encountered in pharmaceutical R&D are not unique, but to learn from other industries it is important to recognise similarity, rather than differences, and to advance industrialisation of R&D beyond technology and automation. Tools like Lean and Six Sigma, already applied to increase business excellence across diverse organisations, can equally be introduced to pharmaceutical R&D and offer the potential to transform operations without large-scale investment.

  16. The impact of global nuclear mass model uncertainties on r-process abundance predictions

    Directory of Open Access Journals (Sweden)

    Mumpower M.

    2015-01-01

    Full Text Available Rapid neutron capture or ‘r-process’ nucleosynthesis may be responsible for half the production of heavy elements above iron on the periodic table. Masses are one of the most important nuclear physics ingredients that go into calculations of r-process nucleosynthesis as they enter into the calculations of reaction rates, decay rates, branching ratios and Q-values. We explore the impact of uncertainties in three nuclear mass models on r-process abundances by performing global monte carlo simulations. We show that root-mean-square (rms errors of current mass models are large so that current r-process predictions are insufficient in predicting features found in solar residuals and in r-process enhanced metal poor stars. We conclude that the reduction of global rms errors below 100 keV will allow for more robust r-process predictions.

  17. Processing of toxicological studies results in the statistical program R

    Directory of Open Access Journals (Sweden)

    Fedoseeva Elena Vasilyevna

    2015-09-01

    Full Text Available The presented article is devoted to the analysis of the experimental values and the applicability of the toxicological studies results in the statistical environment R. This freely distributed program has great functional potential and well-designed algorithm, these make it "...the undisputed leader among the freely distributed systems for statistical analysis..." As the data, the experimental results to assess the toxicity of a highly- mineralized sample in the industrial production wastes were used. We evaluated two test-functions: the change in the population increase of cells and the fluorescence level of laboratory culture of the marine diatom algae Phaeodactylum tricornutum. The detailed algorithm of the analysis, namely: data initialization, evaluation of selective parameters of descriptive statistics, toxicity assessment, single-factor analysis of variance (ANOVA, Tukey and Dunnett multiple comparison tests, evaluation of correlation between the observed variable (Spearman and Pearson correlation coefficients are presented in the article. The complete list of scripts in the program R allows to reproduce a similar analysis.

  18. R-process enrichment from a single event in an ancient dwarf galaxy.

    Science.gov (United States)

    Ji, Alexander P; Frebel, Anna; Chiti, Anirudh; Simon, Joshua D

    2016-03-31

    Elements heavier than zinc are synthesized through the rapid (r) and slow (s) neutron-capture processes. The main site of production of the r-process elements (such as europium) has been debated for nearly 60 years. Initial studies of trends in chemical abundances in old Milky Way halo stars suggested that these elements are produced continually, in sites such as core-collapse supernovae. But evidence from the local Universe favours the idea that r-process production occurs mainly during rare events, such as neutron star mergers. The appearance of a plateau of europium abundance in some dwarf spheroidal galaxies has been suggested as evidence for rare r-process enrichment in the early Universe, but only under the assumption that no gas accretes into those dwarf galaxies; gas accretion favours continual r-process enrichment in these systems. Furthermore, the universal r-process pattern has not been cleanly identified in dwarf spheroidals. The smaller, chemically simpler, and more ancient ultrafaint dwarf galaxies assembled shortly after the first stars formed, and are ideal systems with which to study nucleosynthesis events such as the r-process. Reticulum II is one such galaxy. The abundances of non-neutron-capture elements in this galaxy (and others like it) are similar to those in other old stars. Here, we report that seven of the nine brightest stars in Reticulum II, observed with high-resolution spectroscopy, show strong enhancements in heavy neutron-capture elements, with abundances that follow the universal r-process pattern beyond barium. The enhancement seen in this 'r-process galaxy' is two to three orders of magnitude higher than that detected in any other ultrafaint dwarf galaxy. This implies that a single, rare event produced the r-process material in Reticulum II. The r-process yield and event rate are incompatible with the source being ordinary core-collapse supernovae, but consistent with other possible sources, such as neutron star mergers.

  19. The Hamburg/ESO R-process Enhanced Star survey (HERES) VIII. The r+s star HE 1405 0822

    CERN Document Server

    Cui, W Y; Christlieb, N

    2013-01-01

    Aims.The aim of this study is a detailed abundance analysis of the newly discovered r-rich star HE 1405 0822, which has [Fe=H]=-2.40. This star shows enhancements of both r- and s-elements, [Ba/Fe]= +1.95 and [Eu/Fe]=1.54, for which reason it is called r+s star. Methods.Stellar parameters and element abundances were determined by analying high-quality VLT/UVES spectra. We used Fe I line excitation equilibria to derive the e?ective temperature. The surface gravity was calculated from the Fei/Feii and Ti I/Ti II equilibria. Results.We determined accurate abundances for 39 elements, including 19 neutron-capture elements. HE 1405-0822 is a red giant. Its strong enhancements of C, N, and s-elements are the consequence of enrichment by a former AGB companion with an initial mass of less than 3 M_Sun. The heavy n-capture element abundances (including Eu, Yb, and Hf) seen in HE 1405-0822 do not agree with the r-process pattern seen in strongly r-process-enhanced stars. We discuss possible enrichment scenarios for thi...

  20. Enrichment history of r-process elements shaped by a merger of neutron star pairs

    CERN Document Server

    Tsujimoto, Takuji

    2014-01-01

    The origin of r-process elements remains unidentified and still puzzles us. The recent discovery of evidence for the ejection of r-process elements from a short-duration gamma-ray burst singled out neutron star mergers (NSMs) as their origin. In contrast, core-collapse supernovae are ruled out as the main origin of heavy r-process elements (A>110) by recent numerical simulations. However, the properties characterizing NSM events - their rarity and high yield of r-process elements per event - have been claimed to be incompatible with the observed stellar records on r-process elements in the Galaxy. We add to this picture with our results, which show that the observed constant [r-process/H] ratio in faint dwarf galaxies and one star unusually rich in r-process in the Sculptor galaxy agree well with this rarity of NSM events. Furthermore, we found that a large scatter in the abundance ratios of r-process elements to iron in the Galactic halo can be reproduced by a scheme that incorporates an assembly of various ...

  1. Advanced processing of the Zerodur R glass ceramic

    Science.gov (United States)

    Marx, Thomas A.

    1991-11-01

    The Zerodur glass ceramic is an extraordinary material possessing a very low thermal expansion over a broad temperature range. Depending on the size of the castings, a continuous or a discontinuous melting technology is used in the manufacture of Zerodur. Continuous melters are being operated regularly in Germany and recently in the United States. The latest generation of discontinuous melters started production of 8.2 m spincast telescope blanks in early 1991. Zerodur fusion is a special process to generate lightweighted mirror blanks and special components. It requires glassy material and generates bonds that are as strong as the bulk material. Further process development such as waterjet cutting and insertion technologies are underway and may generate components of unique shapes and performance.

  2. The r-process of stellar nucleosynthesis: Astrophysics and nuclear physics achievements and mysteries

    Science.gov (United States)

    Arnould, M.; Goriely, S.; Takahashi, K.

    2007-09-01

    The r-process, or the rapid neutron-capture process, of stellar nucleosynthesis is called for to explain the production of the stable (and some long-lived radioactive) neutron-rich nuclides heavier than iron that are observed in stars of various metallicities, as well as in the solar system. A very large amount of nuclear information is necessary in order to model the r-process. This concerns the static characteristics of a large variety of light to heavy nuclei between the valley of stability and the vicinity of the neutron-drip line, as well as their beta-decay branches or their reactivity. Fission probabilities of very neutron-rich actinides have also to be known in order to determine the most massive nuclei that have a chance to be involved in the r-process. Even the properties of asymmetric nuclear matter may enter the problem. The enormously challenging experimental and theoretical task imposed by all these requirements is reviewed, and the state-of-the-art development in the field is presented. Nuclear-physics-based and astrophysics-free r-process models of different levels of sophistication have been constructed over the years. We review their merits and their shortcomings. The ultimate goal of r-process studies is clearly to identify realistic sites for the development of the r-process. Here too, the challenge is enormous, and the solution still eludes us. For long, the core collapse supernova of massive stars has been envisioned as the privileged r-process location. We present a brief summary of the one- or multidimensional spherical or non-spherical explosion simulations available to-date. Their predictions are confronted with the requirements imposed to obtain an r-process. The possibility of r-nuclide synthesis during the decompression of the matter of neutron stars following their merging is also discussed. Given the uncertainties remaining on the astrophysical r-process site and on the involved nuclear physics, any confrontation between predicted r-process

  3. The r-process of stellar nucleosynthesis: Astrophysics and nuclear physics achievements and mysteries

    Energy Technology Data Exchange (ETDEWEB)

    Arnould, M. [Institut d' Astronomie et d' Astrophysique, Universite Libre de Bruxelles, CP226, B-1050 Brussels (Belgium)], E-mail: marnould@astro.ulb.ac.be; Goriely, S.; Takahashi, K. [Institut d' Astronomie et d' Astrophysique, Universite Libre de Bruxelles, CP226, B-1050 Brussels (Belgium)

    2007-09-15

    The r-process, or the rapid neutron-capture process, of stellar nucleosynthesis is called for to explain the production of the stable (and some long-lived radioactive) neutron-rich nuclides heavier than iron that are observed in stars of various metallicities, as well as in the solar system. A very large amount of nuclear information is necessary in order to model the r-process. This concerns the static characteristics of a large variety of light to heavy nuclei between the valley of stability and the vicinity of the neutron-drip line, as well as their beta-decay branches or their reactivity. Fission probabilities of very neutron-rich actinides have also to be known in order to determine the most massive nuclei that have a chance to be involved in the r-process. Even the properties of asymmetric nuclear matter may enter the problem. The enormously challenging experimental and theoretical task imposed by all these requirements is reviewed, and the state-of-the-art development in the field is presented. Nuclear-physics-based and astrophysics-free r-process models of different levels of sophistication have been constructed over the years. We review their merits and their shortcomings. The ultimate goal of r-process studies is clearly to identify realistic sites for the development of the r-process. Here too, the challenge is enormous, and the solution still eludes us. For long, the core collapse supernova of massive stars has been envisioned as the privileged r-process location. We present a brief summary of the one- or multidimensional spherical or non-spherical explosion simulations available to-date. Their predictions are confronted with the requirements imposed to obtain an r-process. The possibility of r-nuclide synthesis during the decompression of the matter of neutron stars following their merging is also discussed. Given the uncertainties remaining on the astrophysical r-process site and on the involved nuclear physics, any confrontation between predicted r-process

  4. The r-Process in Metal Poor Stars and Black Hole Formation

    Energy Technology Data Exchange (ETDEWEB)

    Boyd, R N; Famiano, M A; Meyer, B S; Motizuki, Y; Kajino, T; Roederer, I U

    2011-11-30

    Nucleosynthesis of heavy nuclei in metal-poor stars is generally ascribed to the r-process, as the abundance pattern in many such stars agrees with the inferred Solar r-process abundances. Nonetheless, a significant number of these stars do not share this r-process template. they suggest that many such stars have begun an r-process, but it was prevented from running to completion in more massive stars by collapse to black holes, creating a 'truncated r-process,' or 'tr-process'. The observed fraction of tr-process stars is found to be consistent with expectations from the initial mass function (IMF), and they suggest that an apparent sharp truncation observed at around mass 160 could result from a combination of collapses to black holes and the difficulty of observing the higher mass rare earths. They test the tr-process hypothesis with calculations that are terminated before all r-process trajectories have been ejected. These produce qualitative agreement with observation when both black hole collapse and observational realities are taken into account.

  5. RELATIVE CONTRIBUTIONS OF THE WEAK, MAIN, AND FISSION-RECYCLING r-PROCESS

    Energy Technology Data Exchange (ETDEWEB)

    Shibagaki, S.; Kajino, T. [Department of Astronomy, The University of Tokyo, 113-033 Tokyo (Japan); Mathews, G. J.; Nishimura, S. [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo, 181-8588 (Japan); Chiba, S. [Research Laboratory for Nuclear Reactors, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro, Tokyo 152-8550 (Japan); Lorusso, G. [RIKEN Nishina Center, 2-1 Hirosawa, Wako-shi, Saitama 351-0198 (Japan)

    2016-01-10

    There has been a persistent conundrum in attempts to model the nucleosynthesis of heavy elements by rapid neutron capture (the r-process). Although the locations of the abundance peaks near nuclear mass numbers 130 and 195 identify an environment of rapid neutron capture near closed nuclear shells, the abundances of elements just above and below those peaks are often underproduced by more than an order of magnitude in model calculations. At the same time, there is a debate in the literature as to what degree the r-process elements are produced in supernovae or the mergers of binary neutron stars. In this paper we propose a novel solution to both problems. We demonstrate that the underproduction of nuclides above and below the r-process peaks in main or weak r-process models (like magnetohydrodynamic jets or neutrino-driven winds in core-collapse supernovae) can be supplemented via fission fragment distributions from the recycling of material in a neutron-rich environment such as that encountered in neutron star mergers (NSMs). In this paradigm, the abundance peaks themselves are well reproduced by a moderately neutron-rich, main r-process environment such as that encountered in the magnetohydrodynamical jets in supernovae supplemented with a high-entropy, weakly neutron-rich environment such as that encountered in the neutrino-driven-wind model to produce the lighter r-process isotopes. Moreover, we show that the relative contributions to the r-process abundances in both the solar system and metal-poor stars from the weak, main, and fission-recycling environments required by this proposal are consistent with estimates of the relative Galactic event rates of core-collapse supernovae for the weak and main r-process and NSMs for the fission-recycling r-process.

  6. Petri Net-Based R&D Process Modeling and Optimization for Composite Materials

    Directory of Open Access Journals (Sweden)

    Xiaomei Hu

    2013-01-01

    Full Text Available Considering the current R&D process for new composite materials involves some complex details, such as formula design, specimen/sample production, materials/sample test, assessment, materials/sample feedback from customers, and mass production, the workflow model of Petri net-based R&D process for new composite materials’ is proposed. By analyzing the time property of the whole Petri net, the optimized model for new composite materials R&D workflow is further proposed. By analyzing the experiment data and application in some materials R&D enterprise, it is demonstrated that the workflow optimization model shortens the period of R&D on new materials for 15%, definitely improving the R&D efficiency. This indicates the feasibility and availability of the model.

  7. Beta-decay properties of exotic nuclei and the astrophysical r-process

    Energy Technology Data Exchange (ETDEWEB)

    Tachibana, T. [Waseda Univ., Tokyo (Japan). Adv. Res. Center for Sci. and Eng.; Arnould, M. [Institut d`Astronomie et d`Astrophysique, Universite Libre de Bruxelles (Belgium)

    1995-05-29

    The r-process abundances are evaluated with the use of three different, {beta} decay models, i.e., the second version of the Gross Theory, the semi-Gross Theory and a QRPA approach. The necessary Q{sub {beta}}-values, as well as the neutron separation energies, are obtained from the TUYY, ETFSI and FRDM mass predictions. A comparison is made among the {beta}-decay half-lives predicted by these {beta}-decay models for the nuclei on a typical r-process path, as well as among the resulting r-process abundances. ((orig.)).

  8. The Hamburg/ESO R-process Enhanced Star survey (HERES) XI. The highly $r$-process-enhanced star CS 29497-004

    CERN Document Server

    Hill, V; Beers, T C; Barklem, P S; Kratz, K -L; Nordström, B; Pfeiffer, B; Farouqi, K

    2016-01-01

    We report an abundance analysis for the highly r-process-enhanced (r-II) star CS 29497-004, a very metal-poor giant with Teff = 5013K and [Fe/H]=-2.85, whose nature was initially discovered in the course of the HERES project. Our analysis is based on high signal-to-noise, high-resolution (R~75000) VLT/UVES spectra and MARCS model atmospheres under the assumption of local thermodynamic equilibrium, and obtains abundance measurements for a total of 46 elements, 31 of which are neutron-capture elements. As is the case for the other 25 r-II stars currently known, the heavy-element abundance pattern of CS 29497-004 well-matches a scaled Solar System second peak r-process-element abundance pattern. We confirm our previous detection of Th, and demonstrate that this star does not exhibit an "actinide boost". Uranium is also detected (log e(U) =-2.20+/-0.30), albeit with a large measurement error that hampers its use as a precision cosmo-chronometer. Combining the various elemental chronometer pairs that are available...

  9. An r-process Enhanced Star in the Dwarf Galaxy Tucana III

    Science.gov (United States)

    Hansen, T. T.; Simon, J. D.; Marshall, J. L.; Li, T. S.; Carollo, D.; DePoy, D. L.; Nagasawa, D. Q.; Bernstein, R. A.; Drlica-Wagner, A.; Abdalla, F. B.; Allam, S.; Annis, J.; Bechtol, K.; Benoit-Lévy, A.; Brooks, D.; Buckley-Geer, E.; Carnero Rosell, A.; Carrasco Kind, M.; Carretero, J.; Cunha, C. E.; da Costa, L. N.; Desai, S.; Eifler, T. F.; Fausti Neto, A.; Flaugher, B.; Frieman, J.; García-Bellido, J.; Gaztanaga, E.; Gerdes, D. W.; Gruen, D.; Gruendl, R. A.; Gschwend, J.; Gutierrez, G.; James, D. J.; Krause, E.; Kuehn, K.; Kuropatkin, N.; Lahav, O.; Miquel, R.; Plazas, A. A.; Romer, A. K.; Sanchez, E.; Santiago, B.; Scarpine, V.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Walker, A. R.; DES Collaboration

    2017-03-01

    Chemically peculiar stars in dwarf galaxies provide a window for exploring the birth environment of stars with varying chemical enrichment. We present a chemical abundance analysis of the brightest star in the newly discovered ultra-faint dwarf galaxy candidate Tucana III. Because it is particularly bright for a star in an ultra-faint Milky Way (MW) satellite, we are able to measure the abundance of 28 elements, including 13 neutron-capture species. This star, DES J235532.66‑593114.9 (DES J235532), shows a mild enhancement in neutron-capture elements associated with the r-process and can be classified as an r-I star. DES J235532 is the first r-I star to be discovered in an ultra-faint satellite, and Tuc III is the second extremely low-luminosity system found to contain r-process enriched material, after Reticulum II. Comparison of the abundance pattern of DES J235532 with r-I and r-II stars found in other dwarf galaxies and in the MW halo suggests a common astrophysical origin for the neutron-capture elements seen in all r-process enhanced stars. We explore both internal and external scenarios for the r-process enrichment of Tuc III and show that with abundance patterns for additional stars, it should be possible to distinguish between them. This paper includes data gathered with the 6.5 meter Magellan Telescopes located at Las Campanas Observatory, Chile.

  10. The Hamburg/ESO R-process Enhanced Star survey (HERES) X. HE 2252-4225, one more r-process enhanced and actinide-boost halo star

    CERN Document Server

    Mashonkina, L; Eriksson, K

    2014-01-01

    We report on a detailed abundance analysis of the r-process enhanced giant star, HE 2252-4225 ([Fe/H] = -2.63, [r/Fe] = 0.80). Determination of stellar parameters and element abundances was based on analysis of high-quality VLT/UVES spectra. The surface gravity was calculated from the NLTE ionisation balance between Fe I and Fe II. Accurate abundances were determined for a total of 38 elements, including 22 neutron-capture elements beyond Sr and up to Th. This object is deficient in carbon, as expected for a giant star with Teff < 4800 K. The stellar Na-Zn abundances are well fitted by the yields of a single supernova of 14.4 Msun. For the neutron-capture elements in the Sr-Ru, Ba-Yb, and Os-Ir regions, the abundance pattern of HE 2252-4225 is in excellent agreement with the average abundance pattern of the strongly r-process enhanced stars CS 22892-052, CS 31082-001, HE 1219-0312, and HE 1523-091. This suggests a common origin of the first, second, and third r-process peak elements in HE 2252-4225 in the ...

  11. Beta decay rates for nuclei with 115 < < 140 for r-process nucleosynthesis

    Indian Academy of Sciences (India)

    Kamales Kar; Soumya Chakravarti; V R Manfredi

    2006-08-01

    For r-process nucleosynthesis the -decay rates for a number of neutron-rich intermediate heavy nuclei are calculated. The model for the -strength function is able to reproduce the observed half-lives quite well.

  12. Opacities and Spectra of the r-process Ejecta from Neutron Star Mergers

    CERN Document Server

    Kasen, Daniel; Barnes, Jennifer

    2013-01-01

    Material ejected during (or immediately following) the merger of two neutron stars may assemble into heavy elements by the r-process. The subsequent radioactive decay of the nuclei can power electromagnetic emission similar to, but significantly dimmer than, an ordinary supernova. Identifying such events is an important goal of future transient surveys, offering new perspectives on the origin of r-process nuclei and the astrophysical sources of gravitational waves. Predictions of the transient light curves and spectra, however, have suffered from the uncertain optical properties of heavy ions. Here we consider the opacity of expanding r-process material and argue that it is dominated by line transitions from those ions with the most complex valence electron structure, namely the lanthanides. For a few representative ions, we run atomic structure models to calculate radiative data for tens of millions of lines. We find that the resulting r-process opacities are orders of magnitude larger than that of ordinary ...

  13. Local and global effects of beta decays on r-process

    CERN Document Server

    Caballero, O L; Borzov, I N; Langanke, K; Martinez-Pinedo, G

    2014-01-01

    Nuclear beta decay rates are an essential ingredient in simulations of the astrophysical r-process. Most of these rates still rely on theoretical modeling. However, modern radioactive ion-beam facilities have allowed to measure beta half lives of some nuclei on or close to the r-process path. These data indicate that r-process half lives are in general shorter than anticipated in the standard theoretical predictions based on the Finite Range Droplet Model (FRDM). The data have also served as important constraints for improved predictions of half lives based on continuum QRPA calculations on top of the energy-density functional theory. Although these calculations are yet limited to spherical nuclei, they include the important r-process waiting point nuclei close to and at the neutron magic numbers $N=50, 82$ and 126. We have studied the impact of these new experimental and theoretical half lives on r-process nucleosynthesis within the two astrophysical sites currently favored for the r process: the neutrino-dr...

  14. Defects in 18 S or 28 S rRNA processing activate the p53 pathway.

    Science.gov (United States)

    Hölzel, Michael; Orban, Mathias; Hochstatter, Julia; Rohrmoser, Michaela; Harasim, Thomas; Malamoussi, Anastassia; Kremmer, Elisabeth; Längst, Gernot; Eick, Dirk

    2010-02-26

    The p53 tumor suppressor pathway is activated by defective ribosome synthesis. Ribosomal proteins are released from the nucleolus and block human double minute-2 (Hdm2) that targets p53 for degradation. However, it remained elusive how abrogation of individual rRNA processing pathways contributes to p53 stabilization. Here, we show that selective inhibition of 18 S rRNA processing provokes accumulation of p53 as efficiently as abrogated 28 S rRNA maturation. We describe hUTP18 as a novel mammalian rRNA processing factor that is specifically involved in 18 S rRNA production. hUTP18 was essential for the cleavage of the 5'-external transcribed spacer leader sequence from the primary polymerase I transcript, but was dispensable for rRNA transcription. Because maturation of the 28 S rRNA was unaffected in hUTP18-depleted cells, our results suggest that the integrity of both the 18 S and 28 S rRNA synthesis pathways can be monitored independently by the p53 pathway. Interestingly, accumulation of p53 after hUTP18 knock down required the ribosomal protein L11. Therefore, cells survey the maturation of the small and large ribosomal subunits by separate molecular routes, which may merge in an L11-dependent signaling pathway for p53 stabilization.

  15. Enrichment of r-process elements in dwarf spheroidal galaxies in chemo-dynamical evolution model

    CERN Document Server

    Hirai, Yutaka; Saitoh, Takayuki R; Fujii, Michiko S; Hidaka, Jun; Kajino, Toshitaka

    2015-01-01

    The rapid neutron-capture process (r-process) is a major process to synthesize elements heavier than iron, but the astrophysical site(s) of r-process is not identified yet. Neutron star mergers (NSMs) are suggested to be a major r-process site from nucleosynthesis studies. Previous chemical evolution studies however require unlikely short merger time of NSMs to reproduce the observed large star-to-star scatters in the abundance ratios of r-process elements relative to iron, [Eu/Fe], of extremely metal-poor stars in the Milky Way (MW) halo. This problem can be solved by considering chemical evolution in dwarf spheroidal galaxies (dSphs) which would be building blocks of the MW and have lower star formation efficiencies than the MW halo. We demonstrate that enrichment of r-process elements in dSphs by NSMs using an N-body/smoothed particle hydrodynamics code. Our high-resolution model reproduces the observed [Eu/Fe] by NSMs with a merger time of 100 Myr when the effect of metal mixing is taken into account. Thi...

  16. The yields of r-process elements and chemical evolution of the Galaxy

    CERN Document Server

    Chen, Z; Chen, Y P; Cui, W Y; Zhang, B; Chen, Zhe; Zhang, Jiang; Chen, YanPing; Cui, WenYuan; Zhang, Bo

    2006-01-01

    The supernova yields of r-process elements are obtained as a function of the mass of their progenitor stars from the abundance patterns of extremely metal-poor stars on the left-side [Ba/Mg]-[Mg/H] boundary with a procedure proposed by Tsujimoto and Shigeyama. The ejected masses of r-process elements associated with stars of progenitor mass $M_{ms}\\leq18M_{\\odot}$ are infertile sources and the SNe II with 20$M_{\\odot}\\leq M_{ms}\\leq 40M_{\\odot}$are the dominant source of r-process nucleosynthesis in the Galaxy. The ratio of these stars 20$M_{\\odot}\\leq M_{ms}\\leq40M_{\\odot}$ with compared to the all massive stars is about $\\sim$18%. In this paper, we present a simple model that describes a star's [r/Fe] in terms of the nucleosynthesis yields of r-process elements and the number of SN II explosions. Combined the r-process yields obtained by our procedure with the scatter model of the Galactic halo, the observed abundance patterns of the metal-poor stars can be well reproduced

  17. P2Y2 R activation by nucleotides promotes skin wound-healing process.

    Science.gov (United States)

    Jin, Hana; Seo, Jihye; Eun, So Young; Joo, Young Nak; Park, Sang Won; Lee, Jae Heun; Chang, Ki Churl; Kim, Hye Jung

    2014-07-01

    P2Y2 R has been shown to be upregulated in a variety of tissues in response to stress or injury and to mediate tissue regeneration through its ability to activate multiple signalling pathways. This study aimed to investigate the role of P2Y2 R in the wound-healing process and the mechanisms by which P2Y2 R activation promotes wound healing in fibroblasts. The role of P2Y2 R in skin wound healing was examined using a full-thickness skin wound model in wildtype (WT) and P2Y2 R(-/-) mice and an in vitro scratch wound model in control or P2Y2 R siRNA-transfected fibroblasts. WT mice showed significantly decreased wound size compared with P2Y2 R(-/-) mice at day 14 post-wounding, and immunohistochemical analysis showed that a proliferation marker Ki67 and extracellular matrix (ECM)-related proteins VEGF, collagen I, fibronectin and α-SMA were overexpressed in WT mice, which were reduced in P2Y2 R(-/-) mice. Scratch-wounded fibroblasts increased ATP release, which peaked at 5 min. In addition, scratch wounding increased the level of P2Y2 R mRNA. Activation of P2Y2 R by ATP or UTP enhanced proliferation and migration of fibroblasts in in vitro scratch wound assays and were blocked by P2Y2 R siRNA. Finally, ATP or UTP also increased the levels of ECM-related proteins through the activation of P2Y2 R in fibroblasts. This study suggests that P2Y2 R may be a potential therapeutic target to promote wound healing in chronic wound diseases. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. The fundamental role of fission during r-process nucleosynthesis in neutron star mergers

    Energy Technology Data Exchange (ETDEWEB)

    Goriely, S. [Universite Libre de Bruxelles, Institut d' Astronomie et d' Astrophysique, CP-226, Brussels (Belgium)

    2015-02-01

    The rapid neutron-capture process, or r-process, is known to be of fundamental importance for explaining the origin of approximately half of the A > 60 stable nuclei observed in nature. Despite important efforts, the astrophysical site of the r-process remains unidentified. Here we study r-process nucleosynthesis in a material that is dynamically ejected by tidal and pressure forces during the merging of binary neutron stars. r-process nucleosynthesis during the decompression is known to be largely insensitive to the detailed astrophysical conditions because of efficient fission recycling, producing a composition that closely follows the solar r-abundance distribution for nuclei with mass numbers A > 140. Due to the important role played by fission in such a scenario, the impact of fission is carefully analyzed. We consider different state-of-the-art global models for the determination of the fission paths, nuclear level densities at the fission saddle points and fission fragment distributions. Based on such models, the sensitivity of the calculated r-process abundance distribution is studied. The fission path is found to strongly affect the region of heavy nuclei responsible for the fission recycling, while the fission fragment distribution of nuclei along the A ≅ 278 isobars defines the abundance pattern of nuclei produced in the 110 r-process peak around A ≅ 195. (orig.)

  19. The impact of nuclear mass models on r-process nucleosynthesis network calculations

    Science.gov (United States)

    Vaughan, Kelly

    2002-10-01

    An insight into understanding various nucleosynthesis processes is via modelling of the process with network calculations. My project focus is r-process network calculations where the r-process is nucleosynthesis via rapid neutron capture thought to take place in high entropy supernova bubbles. One of the main uncertainties of the simulations is the Nuclear Physics input. My project investigates the role that nuclear masses play in the resulting abundances. The code tecode, involves rapid (n,γ) capture reactions in competition with photodisintegration and β decay onto seed nuclei. In order to fully analyze the effects of nuclear mass models on the relative isotopic abundances, calculations were done from the network code, keeping the initial environmental parameters constant throughout. The supernova model investigated by Qian et al (1996) in which two r-processes, of high and low frequency with seed nucleus ^90Se and of fixed luminosity (fracL_ν_e(0)r_7(0)^2 ˜= 8.77), contribute to the nucleosynthesis of the heavier elements. These two r-processes, however, do not contribute equally to the total abundance observed. The total isotopic abundance produced from both events was therefore calculated using equation refabund. Y(H+L) = fracY(H)+fY(L)f+1 applicability of the P-Scheme in relation to the other mass models to the r-process network calculations. 02 Pscheme Aprahamian,A., Gadala-Maria,A. & Cuka,N. 1996, Revista Mexicana de Fisica,42,1 code Surman,R. & Engel,J. 1998, Phys.Rev. C,54,4 thebibliography

  20. The r-process nucleosynthesis during the decompression of neutron star crust material

    Energy Technology Data Exchange (ETDEWEB)

    Goriely, S. [Institut d' Astronomie et d' Astrophysique, CP-226, Université Libre de Bruxelles, 1050 Brussels (Belgium); Bauswein, A. [Department of Physics, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece and Max-Planck-Institut für Astrophysik, Postfach 1317, 85741 Garching (Germany); Janka, H.-T. [Max-Planck-Institut für Astrophysik, Postfach 1317, 85741 Garching (Germany); Sida, J.-L.; Lemaître, J.-F.; Panebianco, S. [C.E.A. Saclay, Irfu/Service de Physique Nucléaire, 91191 Gif-sur-Yvette (France); Dubray, N.; Hilaire, S. [CEA, DAM, DIF, F-91297 Arpajon (France)

    2014-05-02

    About half of the nuclei heavier than iron observed in nature are produced by the so-called rapid neutron capture process, or r-process, of nucleosynthesis. The identification of the astrophysics site and the specific conditions in which the r-process takes place remains, however, one of the still-unsolved mysteries of modern astrophysics. Another underlying difficulty associated with our understanding of the r-process concerns the uncertainties in the predictions of nuclear properties for the few thousands exotic neutron-rich nuclei involved, for which essentially no experimental data exist. The present paper emphasizes some important future challenges faced by nuclear physics in this problem, particularly in the determination of the nuclear structure properties of exotic neutron-rich nuclei as well as their radiative neutron capture rates and their fission probabilities. These quantities are particularly relevant to determine the composition of the matter resulting from the r-process. Both the astrophysics and the nuclear physics difficulties are critically reviewed with special attention paid to the r-process taking place during the decompression of neutron star matter following the merging of two neutron stars.

  1. Reverse engineering nuclear properties from rare earth abundances in the r process

    Science.gov (United States)

    Mumpower, M. R.; McLaughlin, G. C.; Surman, R.; Steiner, A. W.

    2017-03-01

    The bulk of the rare earth elements are believed to be synthesized in the rapid neutron capture process or r process of nucleosynthesis. The solar r-process residuals show a small peak in the rare earths around A∼ 160, which is proposed to be formed dynamically during the end phase of the r process by a pileup of material. This abundance feature is of particular importance as it is sensitive to both the nuclear physics inputs and the astrophysical conditions of the main r process. We explore the formation of the rare earth peak from the perspective of an inverse problem, using Monte Carlo studies of nuclear masses to investigate the unknown nuclear properties required to best match rare earth abundance sector of the solar isotopic residuals. When nuclear masses are changed, we recalculate the relevant β-decay properties and neutron capture rates in the rare earth region. The feedback provided by this observational constraint allows for the reverse engineering of nuclear properties far from stability where no experimental information exists. We investigate a range of astrophysical conditions with this method and show how these lead to different predictions in the nuclear properties influential to the formation of the rare earth peak. We conclude that targeted experimental campaigns in this region will help to resolve the type of conditions responsible for the production of the rare earth nuclei, and will provide new insights into the longstanding problem of the astrophysical site(s) of the r process.

  2. Process-based Architecture for Robustness Applying Linux isolation mechanism in MG-R

    NARCIS (Netherlands)

    Matsinger, A.A.J.; Kourzanov, P.; Gopakumar, G.N.

    2006-01-01

    This report contains the results of a feasibility study of applyingLinux facilities for isolating and protecting processes, and for communication and synchronisation between processes, to the MG-R architecture so as to improve the robustness. Moreover some guidelines andtrade-offs are discussed how

  3. The impact of individual nuclear properties on $r$-process nucleosynthesis

    CERN Document Server

    Mumpower, M R; McLaughlin, G C; Aprahamian, A

    2015-01-01

    The astrophysical rapid neutron capture process or `$r$ process' of nucleosynthesis is believed to be responsible for the production of approximately half the heavy element abundances found in nature. This multifaceted problem remains one of the greatest open challenges in all of physics. Knowledge of nuclear physics properties such as masses, $\\beta$-decay and neutron capture rates, as well as $\\beta$-delayed neutron emission probabilities are critical inputs that go into calculations of $r$-process nucleosynthesis. While properties of nuclei near stability have been established, much still remains unknown regarding neutron-rich nuclei far from stability that may participate in the $r$ process. Sensitivity studies gauge the astrophysical response of a change in nuclear physics input(s) which allows for the isolation of the most important nuclear properties that shape the final abundances observed in nature. This review summarizes the extent of recent sensitivity studies and highlights how these studies play ...

  4. ENRICHMENT OF r-PROCESS ELEMENTS IN DWARF SPHEROIDAL GALAXIES IN CHEMO-DYNAMICAL EVOLUTION MODEL

    Energy Technology Data Exchange (ETDEWEB)

    Hirai, Yutaka; Kajino, Toshitaka [Department of Astronomy, Graduate School of Science, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Ishimaru, Yuhri [Department of Material Science,International Christian University, 3-10-2 Osawa, Mitaka, Tokyo 181-8585 (Japan); Saitoh, Takayuki R. [Earth-Life Science Institute, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551 (Japan); Fujii, Michiko S.; Hidaka, Jun, E-mail: yutaka.hirai@nao.ac.jp [Division of Theoretical Astronomy, National Astronomical Observatory of Japan, 2-21-1 Osawa Mitaka, Tokyo 181-8588 (Japan)

    2015-11-20

    The rapid neutron-capture process (r-process) is a major process for the synthesis of elements heavier than iron-peak elements, but the astrophysical site(s) of the r-process has not yet been identified. Neutron star mergers (NSMs) are suggested to be a major r-process site according to nucleosynthesis studies. Previous chemical evolution studies, however, required unlikely short merger times of NSMs to reproduce the observed large star-to-star scatters in the abundance ratios of r-process elements to iron: the [Eu/Fe] of extremely metal-poor stars in the Milky Way (MW) halo. This problem can be solved by considering chemical evolution in dwarf spheroidal galaxies (dSphs), which would be building blocks of the MW and have lower star formation efficiencies than the MW halo. We demonstrate the enrichment of r-process elements in dSphs by NSMs using an N-body/smoothed particle hydrodynamics code. Our high-resolution model reproduces the observed [Eu/Fe] due to NSMs with a merger time of 100 Myr when the effect of metal mixing is taken into account. This is because metallicity is not correlated with time ∼300 Myr from the start of the simulation due to the low star formation efficiency in dSphs. We also confirm that this model is consistent with observed properties of dSphs such as radial profiles and metallicity distribution. The merger time and the Galactic rate of NSMs are suggested to be ≲300 Myr and ∼10{sup −4} year{sup −1}, respectively, which are consistent with the values suggested by population synthesis and nucleosynthesis studies. This study supports the argument that NSMs are the major astrophysical site of the r-process.

  5. R-process Experimental Campaign at the National Superconducting Cyclotron Laboratory

    CERN Document Server

    Pereira, J; Quinn, M; Aprahamian, A; Arndt, O; Becerril, A; Elliot, T; Estrade, A; Galaviz, D; Kern, L; Kessler, R; Kratz, K L; Lorusso, G; Mantica, P; Matos, M; Montes, F; Pfeiffer, B; Schatz, H; Schertz, F; Smith, E; Walters, W B; Wöhr, A

    2006-01-01

    A JINA/VISTARS r-process campaign was completed at the A1900 Fragment Separator of the National Superconducting Cyclotron Laboratory in the fall of 2005. The purpose of the campaign was the measurement of the beta-decay half-lives and beta-delayed neutron-emission probabilities of different unknown neutron-rich nuclei participating in the r-process. From these observables it will be possible to extract information about the region between the N=56 sub-shell closure at the sudden onset of deformation at N=60 in the A=100 region, and the potential new shell structures around the possible local, spherical double sub-shell closure at Z=40, N=70, which may help clarify the origin of the calculated r-process abundance deficiencies around A=110. Moreover, the region of the chart of nuclides investigated in the campaign included some important r-process waiting-point nuclei, whose beta-decay properties are crucial for understanding the r-process abundance pattern. Details of this campaign will be presented, emphasizi...

  6. Novel essential gene Involved in 16S rRNA processing in Escherichia coli.

    Science.gov (United States)

    Kurata, Tatsuaki; Nakanishi, Shinobu; Hashimoto, Masayuki; Taoka, Masato; Yamazaki, Yukiko; Isobe, Toshiaki; Kato, Jun-ichi

    2015-02-27

    Biogenesis of ribosomes is a complex process mediated by many factors. While its transcription proceeds, ribosomal RNA (rRNA) folds itself into a characteristic three-dimensional structure through interaction with ribosomal proteins, during which its ends are processed. Here, we show that the essential protein YqgF, a RuvC family protein with an RNase-H-like motif, is involved in the processing of pre-16S rRNA during ribosome maturation. Indeed, pre-16S rRNA accumulated in cells of a temperature-sensitive yqgF mutant (yqgF(ts)) cultured at a non-permissive temperature. In addition, purified YqgF was shown to process the 5' end of pre-16S rRNA within 70S ribosomes in vitro. Mass spectrometry analysis of the total proteins in the yqgF(ts) mutant cells showed that the expression of genes containing multiple Shine-Dalgarno-like sequences was observed to be lower than in wild type. These results are interpreted to indicate that YqgF is involved in a novel enzymic activity necessary for the processing of pre-16S rRNA, thereby affecting elongation of translation.

  7. Complete element abundances of nine stars in the r-process galaxy Reticulum II

    CERN Document Server

    Ji, Alexander P; Simon, Joshua D; Chiti, Anirudh

    2016-01-01

    We present chemical abundances derived from high-resolution Magellan/MIKE spectra of the nine brightest known red giant members of the ultra-faint dwarf galaxy Reticulum II. These stars span the full metallicity range of Ret II (-3.5 < [Fe/H] < -2). Seven of the nine stars have extremely high levels of r-process material ([Eu/Fe]~1.7), in contrast to the extremely low neutron-capture element abundances found in every other ultra-faint dwarf galaxy studied to date. The other two stars are the most metal-poor stars in the system ([Fe/H] < -3), and they have neutron-capture element abundance limits similar to those in other ultra-faint dwarf galaxies. We confirm that the relative abundances of Sr, Y, and Zr in these stars are similar to those found in r-process halo stars but ~0.5 dex lower than the solar r-process pattern. If the universal r-process pattern extends to those elements, the stars in Ret II display the least contaminated known r-process pattern. The abundances of lighter elements up to the...

  8. Cultural differences and process adaptation in international R&D project management

    DEFF Research Database (Denmark)

    Li, Xing; Li, J. Z.

    2009-01-01

    process can be effectively tuned to align with local cultural environment through a new generation stage-gate process model. The overseas company's branch has recognized the need to make its process both faster and more effective for telecommunication software development, and has gained remarkable...... project success. At the same time, lessons and recommendations on the adaptability to Chinese style business and management interactions will be drawn from the case study for international companies that locate R&D projects in China....

  9. A Novel Strategy of Carbon Capture and Sequestration by rHLPD Processing

    Directory of Open Access Journals (Sweden)

    Richard Eric Riman

    2016-01-01

    Full Text Available Monoethanolamine (MEA scrubbing is an energy intensive process for Carbon Capture and Sequestration (CCS due to the regeneration of amine in stripping towers at high temperature (100-120 ºC and the subsequent pressurization of CO2 for geologic sequestration. In this paper, we introduce a novel method, reactive hydrothermal liquid phase densification (rHLPD, which is able to solidify (densify monolithic materials without using high temperature kilns. Then we integrate MEA-based CCS processing and mineral carbonation by using rHLPD technology. This integration is designated as rHLPD-Carbon Sequestration (rHLPD-CS process. Our results show that the CO2 captured in the MEA-CO2 solution was sequestered by the mineral (wollastonite CaSiO3 carbonation at a low operating temperature (60 ºC and simultaneously monolithic materials with a compressive strength of ~121 MPa were formed. This suggests that the use of rHLPD-CS technology eliminates the energy consumed for CO2-MEA stripping and CO2 compression and also sequesters CO2 to form value-added products, which have a potential to be utilized as construction and infrastructure materials. In contrast to the high energy requirements and excessive greenhouse gas emissions from conventional Portland cement manufacturing, our calculations show that the integration of rHLPD and CS technologies provides a low energy alternative to production of traditional cementitious binding materials.

  10. First results from the CARIBU facility: mass measurements on the r-process path.

    Science.gov (United States)

    Van Schelt, J; Lascar, D; Savard, G; Clark, J A; Bertone, P F; Caldwell, S; Chaudhuri, A; Levand, A F; Li, G; Morgan, G E; Orford, R; Segel, R E; Sharma, K S; Sternberg, M G

    2013-08-09

    The Canadian Penning Trap mass spectrometer has made mass measurements of 33 neutron-rich nuclides provided by the new Californium Rare Isotope Breeder Upgrade facility at Argonne National Laboratory. The studied region includes the 132Sn double shell closure and ranges in Z from In to Cs, with Sn isotopes measured out to A=135, and the typical measurement precision is at the 100 ppb level or better. The region encompasses a possible major waiting point of the astrophysical r process, and the impact of the masses on the r process is shown through a series of simulations. These first-ever simulations with direct mass information on this waiting point show significant increases in waiting time at Sn and Sb in comparison with commonly used mass models, demonstrating the inadequacy of existing models for accurate r-process calculations.

  11. R-Process Nucleosynthesis in MHD Jet Explosions of Core-Collapse Supernovae

    Directory of Open Access Journals (Sweden)

    Motoaki Saruwatari

    2013-01-01

    Full Text Available We investigate the r-process nucleosynthesis during the magnetohydrodynamical (MHD explosion of a supernova in a helium star of 3.3 M⊙, where effects of neutrinos are taken into account using the leakage scheme in the two-dimensional (2D hydrodynamic code. Jet-like explosion due to the combined effects of differential rotation and magnetic field is able to erode the lower electron fraction matter from the inner layers. We find that the ejected material of low electron fraction responsible for the r-process comes out from just outside the neutrino sphere deep inside the Fe-core. It is found that heavy element nucleosynthesis depends on the initial conditions of rotational and magnetic fields. In particular, the third peak of the distribution is significantly overproduced relative to the solar system abundances, which would indicate a possible r-process site owing to MHD jets in supernovae.

  12. Stimulation of pri-miR-18a Processing by hnRNP A1.

    Science.gov (United States)

    Michlewski, Gracjan; Guil, Sonia; Cáceres, Javier F

    2011-01-01

    Recent evidence suggests that the canonical miRNA processing pathway can be regulated by a number of positive and negative trans-acting factors. This chapter provides an overview of hnRNP Al-mediated regulation of miR-18a biogenesis. Our laboratory has recently established that the multifunctional RNA-binding protein hnRNP Al is required for the processing of miR-18a at the nuclear step of Drosha-mediated processing. By combining structural and functional analysis of RNA, we showed that hnRNP Al regulates the processing of pri-miR-18a by binding to its terminal loop and reshaping its stem-loop structure, thus allowing for a more effective Drosha cleavage. Furthermore, we linked the event of hnRNP A1-binding to the pri-miR-18a with an unusual phylogenetic sequence conservation of its terminal loop. Bioinformatic and mutational analysis revealed that a number of pri-miRNAs have highly conserved terminal loops, which are predicted to act as landing pads for trans-acting factors influencing miRNA processing. These results underscore a previously uncharacterized role for general RNA-binding proteins as factors that facilitate the processing of specific miRNAs, revealing an additional level of complexity for the regulation of miRNA production and function.

  13. Characterizing clearance of helper adenovirus by a clinical rAAV1 manufacturing process.

    Science.gov (United States)

    Thorne, Barbara A; Quigley, Paulene; Nichols, Gina; Moore, Christine; Pastor, Eric; Price, David; Ament, Jon W; Takeya, Ryan K; Peluso, Richard W

    2008-01-01

    Recombinant adeno-associated viral vectors (rAAV) are being developed as gene therapy delivery vehicles and as genetic vaccines, and some of the most scaleable manufacturing methods for rAAV use live adenovirus to induce production. One aspect of establishing safety of rAAV products is therefore demonstrating adequate and reliable clearance of this helper virus by the vector purification process. The ICH Q5A regulatory guidance on viral safety provides recommendations for process design and characterization of viral clearance for recombinant proteins, and these principles were adapted to a rAAV serotype 1 purification process for clinical vectors. Specific objectives were to achieve overall adenovirus clearance factors significantly greater than input levels by using orthogonal separation and inactivation methods, and to segregate adenovirus from downstream operations by positioning a robust clearance step early in the process. Analytical tools for process development and characterization addressed problematic in-process samples, and a viral clearance validation study was performed using adenovirus and two non-specific model viruses. Overall clearance factors determined were >23 LRV for adenovirus, 11 LRV for BVDV, and >23 LRV for AMuLV.

  14. Beta Decays of Isotones with Neutron Magic Number of N=126 and R-process Nucleosynthesis

    CERN Document Server

    Suzuki, Toshio; Kajino, Toshitaka; Otsuka, Takaharu

    2011-01-01

    Beta decays of the isotones with N=126 are studied by shell model calculations taking into account both the Gamow-Teller (GT) and first-forbidden (FF) transitions. The FF transitions are found to be important to reduce the half-lives, by nearly twice to several times, from those by the GT contributions only. Possible implications of the short half-lives of the waiting point nuclei on the r-process nucleosynthesis during the supernova explosions are discussed. A slight shift of the third peak of the element abundances in the r-process toward higher mass region is found.

  15. {beta}-decay studies of r-process nuclei at NSCL

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, J. [National Superconducting Cyclotron Laboratory, Michigan State University, E. Lansing, MI (United States); Joint Institute for Nuclear Astrophysics, Michigan State University, E. Lansing, MI (United States)], E-mail: pereira@nscl.msu.edu; Aprahamian, A. [Institute of Structure and Nuclear Astrophysics, University of Notre Dame, South Bend, IN (United States); Joint Institute for Nuclear Astrophysics, University of Notre Dame, South Bend, IN (United States); Arndt, O. [Institut fuer Kernchemie, Universitaet Mainz, Mainz (Germany); Virtuelles Institut fuer Struktur der Kerne and Nuklearer Astrophysik, Mainz (Germany); Becerril, A.; Elliot, T. [National Superconducting Cyclotron Laboratory, Michigan State University, E. Lansing, MI (United States); Joint Institute for Nuclear Astrophysics, Michigan State University, E. Lansing, MI (United States); Estrade, A. [National Superconducting Cyclotron Laboratory, Michigan State University, E. Lansing, MI (United States); Joint Institute for Nuclear Astrophysics, Michigan State University, E. Lansing, MI (United States); Department of Physics and Astronomy, Michigan State University, E. Lansing, MI (United States); Galaviz, D. [National Superconducting Cyclotron Laboratory, Michigan State University, E. Lansing, MI (United States); Joint Institute for Nuclear Astrophysics, Michigan State University, E. Lansing, MI (United States); Hennrich, S. [Institut fuer Kernchemie, Universitaet Mainz, Mainz (Germany); Virtuelles Institut fuer Struktur der Kerne and Nuklearer Astrophysik, Mainz (Germany); Hosmer, P. [National Superconducting Cyclotron Laboratory, Michigan State University, E. Lansing, MI (United States); Joint Institute for Nuclear Astrophysics, Michigan State University, E. Lansing, MI (United States); Department of Physics and Astronomy, Michigan State University, E. Lansing, MI (United States)] (and others)

    2008-06-01

    Observed neutron-capture elemental abundances in metal-poor stars, along with ongoing analysis of the extremely metal-poor Eu-enriched sub-class provide new guidance for astrophysical models aimed at finding the r-process sites. The present paper emphasizes the importance of nuclear physics parameters entering in these models, particularly {beta}-decay properties of neutron-rich nuclei. In this context, several r-process motivated {beta}-decay experiments performed at the National Superconducting Cyclotron Laboratory (NSCL) are presented, including a summary of results and impact on model calculations.

  16. Beta decay studies of r-process nuclei at the National Superconducting Cyclotron Laboratory

    CERN Document Server

    Pereira, J; Arndt, O; Becerril, A; Elliot, T; Estrade, A; Galaviz, D; Hennrich, S; Hosmer, P; Kessler, R; Kratz, K L; Lorusso, G; Mantica, P F; Matos, M; Montes, F; Santi, P; Pfeiffer, B; Quinn, M; Schatz, H; Schertz, F; Schnorrenberger, L; Smith, E; Tomlin, B E; Walters, W; Wöhr, A

    2009-01-01

    The impact of nuclear physics on astrophysical r-process models is discussed, emphasizing the importance of beta-decay properties of neutron-rich nuclei. Several r-process motivated beta-decay experiments performed at the National Superconducting Cyclotron Laboratory are presented. The experiments include the measurement of beta-decay half-lives and neutron emission probabilities of nuclei in regions around Ni-78; Se-90; Zr-106 and Rh-120, as well as spectroscopic studies of Pd-120. A summary on the different experimental techniques employed, data analysis, results and impact on model calculations is presented.

  17. β-decay studies of r-process nuclei at NSCL

    Science.gov (United States)

    Pereira, J.; Aprahamian, A.; Arndt, O.; Becerril, A.; Elliot, T.; Estrade, A.; Galaviz, D.; Hennrich, S.; Hosmer, P.; Schnorrenberger, L.; Kessler, R.; Kratz, K.-L.; Lorusso, G.; Mantica, P. F.; Matos, M.; Montes, F.; Pfeiffer, B.; Quinn, M.; Santi, P.; Schatz, H.; Schertz, F.; Smith, E.; Tomlin, B. E.; Walters, W. B.; Wöhr, A.

    2008-06-01

    Observed neutron-capture elemental abundances in metal-poor stars, along with ongoing analysis of the extremely metal-poor Eu-enriched sub-class provide new guidance for astrophysical models aimed at finding the r-process sites. The present paper emphasizes the importance of nuclear physics parameters entering in these models, particularly β-decay properties of neutron-rich nuclei. In this context, several r-process motivated β-decay experiments performed at the National Superconducting Cyclotron Laboratory (NSCL) are presented, including a summary of results and impact on model calculations.

  18. R-matrix theory of atomic collisions. Application to atomic, molecular and optical processes

    Energy Technology Data Exchange (ETDEWEB)

    Burke, Philip G. [Queen' s Univ., Belfast (United Kingdom). School of Mathematics and Physics

    2011-07-01

    Commencing with a self-contained overview of atomic collision theory, this monograph presents recent developments of R-matrix theory and its applications to a wide-range of atomic molecular and optical processes. These developments include electron and photon collisions with atoms, ions and molecules required in the analysis of laboratory and astrophysical plasmas, multiphoton processes required in the analysis of superintense laser interactions with atoms and molecules and positron collisions with atoms and molecules required in antimatter studies of scientific and technological importance. Basic mathematical results and general and widely used R-matrix computer programs are summarized in the appendices. (orig.)

  19. R-Matrix Theory of Atomic Collisions Application to Atomic, Molecular and Optical Processes

    CERN Document Server

    Burke, Philip George

    2011-01-01

    Commencing with a self-contained overview of atomic collision theory, this monograph presents recent developments of R-matrix theory and its applications to a wide-range of atomic molecular and optical processes. These developments include electron and photon collisions with atoms, ions and molecules required in the analysis of laboratory and astrophysical plasmas, multiphoton processes required in the analysis of superintense laser interactions with atoms and molecules and positron collisions with atoms and molecules required in antimatter studies of scientific and technologial importance. Basic mathematical results and general and widely used R-matrix computer programs are summarized in the appendices.

  20. The Link between Rare-Earth Peak Formation and the Astrophysical Site of the R Process

    Science.gov (United States)

    Mumpower, Matthew R.; McLaughlin, Gail C.; Surman, Rebecca; Steiner, Andrew W.

    2016-12-01

    The primary astrophysical source of the rare-earth elements is the rapid neutron capture process (r process). The rare-earth peak that is seen in the solar r-process residuals has been proposed to originate as a pile-up of nuclei during the end of the r process. We introduce a new method utilizing Monte Carlo studies of nuclear masses in the rare-earth region, that includes self-consistently adjusting β-decay rates and neutron capture rates, to find the mass surfaces necessary for the formation of the rare-earth peak. We demonstrate our method with two types of astrophysical scenario, one corresponding to conditions typical of hot winds from core-collapse supernovae and stellar-mass accretion disks, and one corresponding to conditions typical of the ejection of the material from the tidal tails of neutron star mergers. In each type of astrophysical condition, this method successfully locates a region of enhanced stability in the mass surface that is responsible for the rare-earth peak. For each scenario, we find that the change in the mass surface has qualitatively different features, thus future measurements can shed light on the type of environment in which the r process occurred.

  1. Reverse engineering nuclear properties from rare earth abundances in the $r$ process

    CERN Document Server

    Mumpower, M R; Surman, R; Steiner, A W

    2016-01-01

    The bulk of the rare earth elements are believed to be synthesized in the rapid neutron capture process or $r$ process of nucleosynthesis. The solar $r$-process residuals show a small peak in the rare earths around $A\\sim 160$, which is proposed to be formed dynamically during the end phase of the $r$ process by a pileup of material. This abundance feature is of particular importance as it is sensitive to both the nuclear physics inputs and the astrophysical conditions of the main $r$ process. We explore the formation of the rare earth peak from the perspective of an inverse problem, using Monte Carlo studies of nuclear masses to investigate the unknown nuclear properties required to best match rare earth abundance sector of the solar isotopic residuals. When nuclear masses are changed, we recalculate the relevant $\\beta$-decay properties and neutron capture rates in the rare earth region. The feedback provided by this observational constraint allows for the reverse engineering of nuclear properties far from ...

  2. WASTE PROCESSING ANNUAL NUCLEAR SAFETY RELATED R AND D REPORT FOR CY2008

    Energy Technology Data Exchange (ETDEWEB)

    Fellinger, A.

    2009-10-15

    The Engineering and Technology Office of Waste Processing identifies and reduces engineering and technical risks associated with key waste processing project decisions. The risks, and actions taken to mitigate those risks, are determined through technology readiness assessments, program reviews, technology information exchanges, external technical reviews, technical assistance, and targeted technology development and deployment (TDD). The Office of Waste Processing TDD program prioritizes and approves research and development scopes of work that address nuclear safety related to processing of highly radioactive nuclear wastes. Thirteen of the thirty-five R&D approved work scopes in FY2009 relate directly to nuclear safety, and are presented in this report.

  3. NHPoisson: An R Package for Fitting and Validating Nonhomogeneous Poisson Processes

    Directory of Open Access Journals (Sweden)

    Ana C. Cebrián

    2015-03-01

    Full Text Available NHPoisson is an R package for the modeling of nonhomogeneous Poisson processes in one dimension. It includes functions for data preparation, maximum likelihood estimation, covariate selection and inference based on asymptotic distributions and simulation methods. It also provides specific methods for the estimation of Poisson processes resulting from a peak over threshold approach. In addition, the package supports a wide range of model validation tools and functions for generating nonhomogenous Poisson process trajectories. This paper is a description of the package and aims to help those interested in modeling data using nonhomogeneous Poisson processes.

  4. Astrophysical site(s of r-process elements in galactic chemodynamical evolution model

    Directory of Open Access Journals (Sweden)

    Hirai Yutaka

    2016-01-01

    Full Text Available Astrophysical site(s of rapid neutron-capture process (r-process is (are not identified yet. Although core-collapse supernovae have been regarded as one of the possible candidates of the astrophysical site of r-process, nucleosynthesis studies suggest that serious difficulties in core-collapse supernovae to produce heavy elements with mass number of ≳110. Recent studies show that neutron star mergers (NSMs can synthesize these elements due to their neutron rich environment. Some chemical evolution studies of the Milky Way halo, however, hardly reproduce the observed star-to-star scatters of the abundance ratios of r-process elements (e.g., Eu in extremely metal-poor stars. This is because of their low rate (∼ 10−4 yr−1 for a Milky Way size galaxy and long merger time (≳ 100 Myr. This problem might be solved if the stars in the Galactic halo are consisted of the stars formed in dwarf galaxies where the star formation efficiencies were very low. In this study, we carry out numerical simulations of galactic chemo-dynamical evolution using an N-body/smoothed particle hydrodynamics code. We construct detailed chemo-dynamical evolution model for the Local Group dwarf spheroidal galaxies (dSphs assuming that the NSMs are the major source of r-process elements. Our models successfully reproduce the observed dispersion in [Eu/Fe] as a function of [Fe/H] if we set merger time of NSMs, ≲ 300 Myr with the Galactic NSM rate of ∼ 10−4 yr−1. In addition, our results are consistent with the observed metallicity distribution of dSphs. In the early phase (≲1 Gyr of galaxy evolution is constant due to low star formation efficiency of dSphs. This study supports the idea that NSMs are the major site of r-process nucleosynthesis.

  5. r-Process Elements as Tracers of Enrichment Processes in the Early Halo

    Science.gov (United States)

    Andersen, Johannes; Nordström, Birgitta; Hansen, Terese T.

    2016-08-01

    Significant minorities of extremely metal-poor (EMP) halo stars exhibit dramatic excesses of neutron capture elements. The standard scenario for their origin is mass transfer and dilution in binary systems, but requires them to be binaries. If not, these excesses must have been implanted in them from birth by processes that are not included in current models of SN II chemical enrichment. The binary population of such EMP subgroups is a test of this scenario.

  6. r-Process Elements in EMP stars: Indicators of Inhomogeneous Early Halo Enrichment

    Science.gov (United States)

    Andersen, Johannes; Nordström, Birgitta; Thidemann Hansen, Terese

    2015-08-01

    Extremely metal-poor (EMP) halo stars with [Fe/H] below ~ -3 are considered to be fossil records of conditions in the early halo. In the simplest picture where iron is a proxy for overall metallicity and indirectly for time, EMP stars formed before the oldest and most metal-poor Galactic globular clusters. High-resolution spectroscopy with 8m-class telescopes has shown the detailed abundance pattern of these stars to be surprisingly uniform (e.g. Bonifacio+ 2012) and essentially Solar, apart from the α-enhancement typical of SN II nucleosynthesis. A small fraction (~3%) of EMP stars, however, is strongly enhanced in the heaviest (r-process) neutron-capture elements, highlighting that the periodic system of elements was fully populated already this early.These striking departures from the general chemical homogeneity could be produced by local or distant sources. The former case is simple - mass transfer from a binary companion that evolved to produce a highly neutron-rich environment (one or more NS). Alternatively, the r-process elements were formed in a site at interstellar distance and preferentially seeded into the natal clouds of the present-day EMP-r stars. Our long-term, precise monitoring of the radial velocities of a sample of such stars (Hansen+ 2011) disproved the binary hypothesis, which would in fact also fail to explain the existence of r-process poor stars, such as HD 122653. We thus conclude that the chemical enrichment of the early halo was far more complex, patchy and likely anisotropic than assumed in current models of Galactic chemical evolution: The EMP-r stars are not just peculiarities to be ignored, but indicate that a new level of complexity must be invoked. That r-process elements have not (yet) been observed in high-redshift DLA systems is readily explained by their low abundance relative to the lighter species and the rarity of strong enrichment events.

  7. Analysis of Production and Distribution Logistics Processes in Verana, s.r.o.

    OpenAIRE

    Musial, Hubert

    2010-01-01

    The objective of this thesis is to analyze logistics processes of company Verana, s.r.o. both from the cost and feasibility perspective and using this analysis, the thesis investigates the possibility of outsourcing logistics by using a third party, that is a logistics company. Both advantages and disadvantages are addressed and compared to the current state of logistics system in the company.

  8. Searching for New Highly r-Process-Enhanced Stars in the Halo of the Milky Way

    Science.gov (United States)

    Beers, Timothy C.; Placco, Vinicius; Holmbeck, Erika M.; Hansen, Terese T.; Simon, Joshua D.; Thompson, Ian; Frebel, Anna

    2017-01-01

    Great progress has been made in recent years concerning understanding and constraining the nature of the astrophysical r-process, and on obtaining evidence for the likely astrophysical site(s) of its production. One of the keys to this progress was the identification, over 20 years ago, of a rare class of VMP stars ([Fe/H] Science Foundation.

  9. r-process Production Sites as inferred from Eu Abundances in Dwarf Galaxies

    CERN Document Server

    Beniamini, Paz; Piran, Tsvi

    2016-01-01

    Recent observations of $r$-process material in ultra-faint dwarf galaxies (UFDs) shed light on the sources of these elements. Strong upper limits on the Eu mass in some UFDs combined with detections of much larger masses in a UFD, Reticulum II, and other dwarf galaxies imply that Eu production is dominated by rare events, and that the minimal Eu mass observed in any UFD is approximately the amount of Eu mass produced per event. This is consistent with other independent observations in the Galaxy. We estimate, using a model independent likelihood analysis, the rate and Eu (Fe) mass produced per $r$-process (Fe production) event in dwarf galaxies including classical dwarfs and UFDs. The mass and rate of the Fe production events are consistent with the normal core-collapse supernova~(ccSN) scenario. The Eu mass per event is $3\\times 10^{-5}M_{\\odot}<\\tilde{m}_{\\rm Eu}<2\\times 10^{-4}M_{\\odot}$, corresponding to a total $r$-process mass per event of $6\\times 10^{-3}M_{\\odot}<\\tilde{m}_{r-process}<4\\ti...

  10. New fission fragment distributions and r-process origin of the rare-earth elements

    CERN Document Server

    Goriely, S; Lemaitre, J -F; Panebianco, S; Dubray, N; Hilaire, S; Bauswein, A; Janka, H -Thomas

    2013-01-01

    Neutron star (NS) merger ejecta offer a viable site for the production of heavy r-process elements with nuclear mass numbers A > 140. The crucial role of fission recycling is responsible for the robustness of this site against many astrophysical uncertainties, but calculations sensitively depend on nuclear physics. In particular the fission fragment yields determine the creation of 110 140.

  11. Detailed Chemical Abundances in the r-Process-Rich Ultra-Faint Dwarf Galaxy Reticulum 2

    CERN Document Server

    Roederer, Ian U; Bailey, John I; Song, Yingyi; Bell, Eric F; Crane, Jeffrey D; Loebman, Sarah; Nidever, David L; Olszewski, Edward W; Shectman, Stephen A; Thompson, Ian B; Valluri, Monica; Walker, Matthew G

    2016-01-01

    The ultra-faint dwarf galaxy Reticulum 2 (Ret 2) was recently discovered in images obtained by the Dark Energy Survey. We have observed the four brightest red giants in Ret 2 at high spectral resolution using the Michigan/Magellan Fiber System. We present detailed abundances for as many as 20 elements per star, including 12 elements heavier than the Fe group. We confirm previous detection of high levels of r-process material in Ret 2 (mean [Eu/Fe]=+1.69+/-0.05) found in three of these stars (mean [Fe/H]=-2.88+/-0.10). The abundances closely match the r-process pattern found in the well-studied metal-poor halo star CS22892-052. Such r-process-enhanced stars have not been found in any other ultra-faint dwarf galaxy, though their existence has been predicted by at least one model. The fourth star in Ret 2 ([Fe/H]=-3.42+/-0.20) contains only trace amounts of Sr ([Sr/Fe]=-1.73+/-0.43) and no detectable heavier elements. One r-process enhanced star is also enhanced in C (natal [C/Fe]=+1.1). This is only the third s...

  12. Relative contributions of the weak, main and fission-recycling r-process

    CERN Document Server

    Shibagaki, S; Mathews, G J; Chiba, S; Nishimura, S; Lorusso, G

    2015-01-01

    There has been a persistent conundrum in attempts to model the nucleosynthesis of heavy elements by rapid neutron capture (the $r$-process). Although the location of the abundance peaks near nuclear mass numbers 130 and 195 identify an environment of rapid neutron capture near closed nuclear shells, the abundances of elements just above and below those peaks are often underproduced by more than an order of magnitude in model calculations. At the same time there is a debate in the literature as to what degree the $r$-process elements are produced in supernovae or the mergers of binary neutron stars. In this paper we propose a novel solution to both problems. We demonstrate that the underproduction of elements above and below the $r$-process peaks characteristic in the main or weak $r$-process events (like magnetohydrodynamic jets or neutrino-driven winds in core-collapse supernovae) can be supplemented via fission fragment distributions from the recycling of material in a neutron-rich environment such as that ...

  13. On the robustness of the r-process in neutron-star mergers

    CERN Document Server

    Mendoza-Temis, Joel de Jesús; Langanke, K; Bauswein, A; Janka, H -T

    2014-01-01

    We have performed r-process simulations for a set of trajectories describing matter ejected in neutron star mergers. Our calculations consider an extended nuclear network, including spontaneous, $\\beta$- and neutron-induced fission and adopting fission yield distributions from the ABLA code. In particular we have studied the sensitivity of the r-process abundances on the nuclear mass models by using different models. We find that the general features of the observed r-process abundance distribution (the second and third peaks, the rare-earth peak and the lead peak) are reproduced by our simulations, independently of the merger trajectory, and for all mass models. We find distinct differences in the predictions of the mass models at and just above the third peak, which can be traced back to different predictions of neutron separation energies for r-process nuclei around neutron number N=130. In all simulations, we find that the second peak around $A\\sim 130$ is produced by the fission yields of the material th...

  14. Process Systems Engineering R&D for Advanced Fossil Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Zitney, S.E.

    2007-09-11

    This presentation will examine process systems engineering R&D needs for application to advanced fossil energy (FE) systems and highlight ongoing research activities at the National Energy Technology Laboratory (NETL) under the auspices of a recently launched Collaboratory for Process & Dynamic Systems Research. The three current technology focus areas include: 1) High-fidelity systems with NETL's award-winning Advanced Process Engineering Co-Simulator (APECS) technology for integrating process simulation with computational fluid dynamics (CFD) and virtual engineering concepts, 2) Dynamic systems with R&D on plant-wide IGCC dynamic simulation, control, and real-time training applications, and 3) Systems optimization including large-scale process optimization, stochastic simulation for risk/uncertainty analysis, and cost estimation. Continued R&D aimed at these and other key process systems engineering models, methods, and tools will accelerate the development of advanced gasification-based FE systems and produce increasingly valuable outcomes for DOE and the Nation.

  15. Variance to mean ratio, R(t), for poisson processes on phylogenetic trees.

    Science.gov (United States)

    Goldman, N

    1994-09-01

    The ratio of expected variance to mean, R(t), of numbers of DNA base substitutions for contemporary sequences related by a "star" phylogeny is widely seen as a measure of the adherence of the sequences' evolution to a Poisson process with a molecular clock, as predicted by the "neutral theory" of molecular evolution under certain conditions. A number of estimators of R(t) have been proposed, all predicted to have mean 1 and distributions based on the chi 2. Various genes have previously been analyzed and found to have values of R(t) far in excess of 1, calling into question important aspects of the neutral theory. In this paper, I use Monte Carlo simulation to show that the previously suggested means and distributions of estimators of R(t) are highly inaccurate. The analysis is applied to star phylogenies and to general phylogenetic trees, and well-known gene sequences are reanalyzed. For star phylogenies the results show that Kimura's estimators ("The Neutral Theory of Molecular Evolution," Cambridge Univ. Press, Cambridge, 1983) are unsatisfactory for statistical testing of R(t), but confirm the accuracy of Bulmer's correction factor (Genetics 123: 615-619, 1989). For all three nonstar phylogenies studied, attained values of all three estimators of R(t), although larger than 1, are within their true confidence limits under simple Poisson process models. This shows that lineage effects can be responsible for high estimates of R(t), restoring some limited confidence in the molecular clock and showing that the distinction between lineage and molecular clock effects is vital.(ABSTRACT TRUNCATED AT 250 WORDS)

  16. Cerebral Processing of Prosodic Emotional Signals: Evaluation of a Network Model Using rTMS

    Science.gov (United States)

    Plewnia, Christian; Wildgruber, Dirk

    2014-01-01

    A great number of functional imaging studies contributed to developing a cerebral network model illustrating the processing of prosody in the brain. According to this model, the processing of prosodic emotional signals is divided into three main steps, each related to different brain areas. The present study sought to evaluate parts of the aforementioned model by using low-frequency repetitive transcranial magnetic stimulation (rTMS) over two important brain regions identified by the model: the superior temporal cortex (Experiment 1) and the inferior frontal cortex (Experiment 2). The aim of both experiments was to reduce cortical activity in the respective brain areas and evaluate whether these reductions lead to measurable behavioral effects during prosody processing. However, results obtained in this study revealed no rTMS effects on the acquired behavioral data. Possible explanations for these findings are discussed in the paper. PMID:25171220

  17. CIS Modules Process R&D: Final Technical Report, October 2005 - June 2006

    Energy Technology Data Exchange (ETDEWEB)

    Tarrant, D. E.; Gay, R. R.

    2006-07-01

    The primary objectives of this subcontract were to: address key near-term technical R&D issues for continued improvement in thin-film PV products; continue process development for increased production capacity; pursue long-term R&D contributing to progress toward the MYTP goals for 2020 to increase the conversion efficiency to 15% and reduce module manufacturing costs to less than $50/m2, thus enabling PV systems with a 30-year lifetime at an installed cost of under $2.00/W; and advance the understanding of the requirements needed to achieve better thin-film PV cell and module performance, greater reliability and market acceptance, and investigate materials systems and new devices that can improve the cost/performance ratio of future thin-film PV factories. The demonstrated and maintained high production yield is a major accomplishment supporting attractive cost projections for CIS. Process R&D at successive levels of CIS production has led to the continued demonstration of the prerequisites for commitment to large-scale commercialization. Process and packaging R&D during this and previous subcontracts has demonstrated the potential for further cost and performance improvements.

  18. The intermediate r-process in core-collapse supernovae driven by the magneto-rotational instability

    CERN Document Server

    Nishimura, Nobuya; Takiwaki, Tomoya; Yamada, Shoichi; Thielemann, Friedrich-Karl

    2016-01-01

    Magneto-rotational supernovae are a possible astrophysical site of r-process nucleosynthesis, however, we have insufficient understanding of the explosion mechanism, especially the enhancement process of magnetic fields. We investigated the nucleosynthetic properties of magneto-rotational supernovae, based on a new explosion mechanism induced by the magneto-rotational instability (MRI). We performed a series of axisymmetric hydrodynamical simulations, numerically resolving the MRI, with detailed microphysics including neutrino heating. Explosion models driven by neutrino heating enhanced by the MRI showed mildly neutron-rich ejecta producing weak r-process nuclei $A \\sim 130$, while an explosion model with a significant effect of magnetic fields reproduces a solar-like r-process pattern. More commonly seen abundance patterns in our models are in between the weak and regular r-process, producing lighter and intermediate mass nuclei. This intermediate r-process exhibits a variety of r-process abundance distribu...

  19. Explosive Percolation in Erd\\"os-R\\'enyi-Like Random Graph Processes

    CERN Document Server

    Panagiotou, Konstantinos; Steger, Angelika; Thomas, Henning

    2011-01-01

    The evolution of the largest component has been studied intensely in a variety of random graph processes, starting in 1960 with the Erd\\"os-R\\'enyi process. It is well known that this process undergoes a phase transition at n/2 edges when, asymptotically almost surely, a linear-sized component appears. Moreover, this phase transition is continuous, i.e., in the limit the function f(c) denoting the fraction of vertices in the largest component in the process after cn edge insertions is continuous. A variation of the Erd\\"os-R\\'enyi process are the so-called Achlioptas processes in which in every step a random pair of edges is drawn, and a fixed edge-selection rule selects one of them to be included in the graph while the other is put back. Recently, Achlioptas, D'Souza and Spencer (2009) gave strong numerical evidence that a variety of edge-selection rules exhibit a discontinuous phase transition. However, Riordan and Warnke (2011) very recently showed that all Achlioptas processes have a continuous phase tran...

  20. R-Process Nucleosynthesis in Dynamically Ejected Matter of Neutron Star Mergers

    CERN Document Server

    Goriely, Stephane; Janka, H -Thomas

    2011-01-01

    Although the rapid neutron-capture process, or r-process, is fundamentally important for explaining the origin of approximately half of the stable nuclei with A > 60, the astrophysical site of this process has not been identified yet. Here we study r-process nucleosynthesis in material that is dynamically ejected by tidal and pressure forces during the merging of binary neutron stars (NSs) and within milliseconds afterwards. For the first time we make use of relativistic hydrodynamical simulations of such events, defining consistently the conditions that determine the nucleosynthesis, i.e., neutron enrichment, entropy, early density evolution and thus expansion timescale, and ejecta mass. We find that 10^{-3}-10^{-2} solar masses are ejected, which is enough for mergers to be the main source of heavy (A > 140) galactic r-nuclei for merger rates of some 10^{-5} per year. While asymmetric mergers eject 2-3 times more mass than symmetric ones, the exact amount depends weakly on whether the NSs have radii of ~15 ...

  1. New Neutron-Capture Measurements in 23 Open Clusters. I. The R-Process

    CERN Document Server

    Overbeek, Jamie C; Jacobson, Heather R

    2016-01-01

    Neutron-capture elements, those with Z > 35, are the least well-understood in terms of nucleosynthesis and formation environments. The rapid neutron-capture, or r-process, elements are formed in the environments and/or remnants of massive stars, while the slow neutron-capture, or s-process, elements are primarily formed in low-mass AGB stars. These elements can provide much information about Galactic star formation and enrichment, but observational data is limited. We have assembled a sample of 68 stars in 23 open clusters that we use to probe abundance trends for six neutron-capture elements (Eu, Gd, Dy, Mo, Pr, and Nd) with cluster age and location in the disk of the Galaxy. In order to keep our analysis as homogenous as possible, we use an automated synthesis fitting program, which also enables us to measure multiple (3-10) lines for each element. We find that the pure r-process elements (Eu, Gd, and Dy) have positive trends with increasing cluster age, while the mixed r- and s- process elements (Mo, Pr, a...

  2. r-Process Nucleosynthesis in Jet-driven Core-Collapse Supernovae

    Science.gov (United States)

    Halevi, Goni; Moesta, Philipp

    2017-01-01

    We investigate rapidly rotating, strongly magnetized core-collapse supernova (CCSN) explosions as a site for the production of heavy elements through r-process nucleosynthesis. While CCSNe have long been considered a potential astrophysical site of this process explaining the origin of observed abundances for stable nuclei heavier than iron, the neutron-rich conditions necessary have not been robustly produced in simulations. There remain large uncertainties in quantifying the fraction of all core-collapse events that produce r-process material and the quantity of ejected material in a typical explosion.We perform three-dimensional (3D) dynamical-spacetime general-relativistic magnetohydrodynamic (GRMHD) simulations of jet-driven CCSNe. These simulations are run using the Einstein toolkit, an open-source community-driven numerical relativity and computational relativistic astrophysics code. They include microphysical finite-temperature equation of state effects and employ a leakage scheme that captures the overall energetics and lepton number exchange due to postbounce neutrino emission. The nuclear products of the simulated explosions are then calculated using SkyNet, a self-heating nuclear reaction network. We explore the robustness of r-process production in magnetorotational core-collapse and the properties of the ejected material.

  3. The r-process of stellar nucleosynthesis: Astrophysics and nuclear physics achievements and mysteries

    CERN Document Server

    Arnould, M; Takahashi, K

    2007-01-01

    The r-process, or the rapid neutron-capture process, of stellar nucleosynthesis is called for to explain the production of the stable (and some long-lived radioactive) neutron-rich nuclides heavier than iron that are observed in stars of various metallicities, as well as in the solar system. A very large amount of nuclear information is necessary in order to model the r-process. This concerns the static characteristics of a large variety of light to heavy nuclei between the valley of stability and the vicinity of the neutron-drip line, as well as their beta-decay branches or their reactivity. The enormously challenging experimental and theoretical task imposed by all these requirements is reviewed, and the state-of-the-art development in the field is presented. Nuclear-physics-based and astrophysics-free r-process models of different levels of sophistication have been constructed over the years. We review their merits and their shortcomings. For long, the core collapse supernova of massive stars has been envi...

  4. The link between rare earth peak formation and the astrophysical site of the $r$ process

    CERN Document Server

    Mumpower, M R; Surman, R; Steiner, A W

    2016-01-01

    The primary astrophysical source of the rare earth elements is the rapid neutron capture process ($r$ process). The rare earth peak that is seen in the solar $r$-process residuals has been proposed to originate as a pile-up of nuclei during the end of the $r$ process. We introduce a new method utilizing Monte Carlo studies of nuclear masses in the rare earth region, that includes self-consistently adjusting $\\beta$-decay rates and neutron capture rates, to find the mass surfaces necessary for the formation of the rare earth peak. We demonstrate our method with two types of astrophysical scenarios, one corresponding conditions typical of core-collapse supernova winds and one corresponding to conditions typical of the ejection of the material from the tidal tails of neutron star mergers. In each type of astrophysical conditions, this method successfully locates a region of enhanced stability in the mass surface that is responsible for the rare earth peak. For each scenario, we find that the change in the mass s...

  5. Neutrino-heated winds from millisecond protomagnetars as sources of the weak r-process

    Science.gov (United States)

    Vlasov, Andrey D.; Metzger, Brian D.; Lippuner, Jonas; Roberts, Luke F.; Thompson, Todd A.

    2017-06-01

    We explore heavy element nucleosynthesis in neutrino-driven winds from rapidly rotating, strongly magnetized protoneutron stars ('millisecond protomagnetars') for which the magnetic dipole is aligned with the rotation axis, and the field is assumed to be a static force-free configuration. We process the protomagnetar wind trajectories calculated by Vlasov, Metzger & Thompson through the r-process nuclear reaction network SkyNet using contemporary models for the evolution of the wind electron fraction during the protoneutron star cooling phase. Although we do not find a successful second or third-peak r-process for any rotation period P, we show that protomagnetars with P ˜ 1-5 ms produce heavy element abundance distributions that extend to higher nuclear mass number than from otherwise equivalent spherical winds (with the mass fractions of some elements enhanced by factors of ≳100-1000). The heaviest elements are synthesized by outflows emerging along flux tubes that graze the closed zone and pass near the equatorial plane outside the light cylinder. Due to dependence of the nucleosynthesis pattern on the magnetic field strength and rotation rate of the protoneutron star, natural variations in these quantities between core collapse events could contribute to the observed diversity of the abundances of weak r-process nuclei in metal-poor stars. Further diversity, including possibly even a successful third-peak r-process, could be achieved for misaligned rotators with non-zero magnetic inclination with respect to the rotation axis. If protomagnetars are central engines for GRBs, their relativistic jets should contain a high-mass fraction of heavy nuclei of characteristic mass number \\bar{A}≈ 100, providing a possible source for ultrahigh energy cosmic rays comprised of heavy nuclei with an energy spectrum that extends beyond the nominal Grezin-Zatsepin-Kuzmin cut-off for protons or iron nuclei.

  6. Hans A. Bethe Prize: Astrophysical, observational and nuclear-physics aspects of r-process nucleosynthesis

    Science.gov (United States)

    Kratz, Karl-Ludwig

    2014-03-01

    Guided by the Solar System (S.S.) abundance peaks at A ~= 130 and A ~= 195, the basic mechanisms for the rapid neutron-capture process (the r-process) have been known for over 50 years. However, even today, all proposed scenarios and sites face problems with astrophysical conditions as well as with the necessary nuclear-physics input. In my talk, I will describe efforts in experimental and theoretical nuclear-structure data for modeling today's three groups of r-process ``observables'', i.e. the bulk S.S. isotopic abundances, the elemental abundances in metal-poor halo stars, and peculiar isotopic patterns measured in certain cosmic stardust grains. To set a historical basis, I will briefly recall our site-independent ``waiting-point'' model, with superpositions of neutron-density components and the use of the first global, unified nuclear input based on the mass model FRDM(1992). This approach provided a considerable leap forward in the basic understanding of the required astrophysical conditions, as well as of specific shell-structure properties far from stability. Starting in the early millenium, the above simple model has been replaced by more realistic, dynamical parameter studies within the high-entropy wind scenario of core-collapse supernovae, now with superpositions of entropy (S) and electron-fraction (Ye) components. Furthermore, an improved, global set of nuclear-physics data is used today, based on the new mass model FRDM(2012). With this nuclear and astrophysics parameter combination, a new fit to the S.S. r-abundances will be shown, and its improvements and remaining deficiencies in terms of underlying shell structure will be discussed. Concerning the abundance patterns in metal-poor halo stars, an interpretation of the production of ``r-rich'' (e.g. CS 22892-052) and ``r-poor'' (e.g. HD 122563) stars in terms of different (Ye), S combinations will be presented. Finally, for the third group of ``r-observables'', a possible origin of the anomalous Xe

  7. Solution-Processed rGO/AgNPs/rGO Sandwich Structure as a Hole Extraction Layer for Polymer Solar Cells

    Directory of Open Access Journals (Sweden)

    Quang Trung Tran

    2015-01-01

    Full Text Available We found that inserting silver nanoparticles (AgNPs between two layers of reduced grapheme oxide (rGO has an effect on tailoring the work function of rGO. The utilization of rGO/AgNPs/rGO sandwich structure as the hole extraction layer in polymer solar cells is demonstrated. Solution-processable fabrication of this sandwich structure at the ITO/active layer interface facilitates the extraction of hole from active layer into ITO anode because of lowering the barrier level alignment at the interface. It results in an improvement of the short circuit current density and the overall photovoltaic performance.

  8. Approximating the r-Process on Earth with Thermonuclear Explosions. Lessons Learned and Unanswered Questions

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Stephen Allan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-01-28

    During the astrophysical r-process, multiple neutron captures occur so rapidly on target nuclei that their daughter nuclei generally do not have time to undergo radioactive decay before another neutron is captured. The r-process can be approximately simulated on Earth in certain types of thermonuclear explosions through an analogous process of rapid neutron captures known as the "prompt capture" process. Between 1952 and 1969, 23 nuclear tests were fielded by the US which were involved (at least partially) with the "prompt capture" process. Of these tests, 15 were at least partially successful. Some of these tests were conducted under the Plowshare Peaceful Nuclear Explosion Program as scientific research experiments. It is now known that the USSR conducted similar nuclear tests during 1966 to 1979. The elements einsteinium and fermium were first discovered by this process. The most successful tests achieved 19 successive neutron captures on the initial target nuclei. A review of the US program, target nuclei used, heavy element yields, scientific achievements of the program, and how some of the results have been used by the astrophysical community is given. Finally, some unanswered questions concerning very neutron-rich nuclei that could potentially have been answered with additional nuclear experiments is presented.

  9. Evidence for supernova injection into the solar nebula and the decoupling of r-process nucleosynthesis.

    Science.gov (United States)

    Brennecka, Gregory A; Borg, Lars E; Wadhwa, Meenakshi

    2013-10-22

    The isotopic composition of our Solar System reflects the blending of materials derived from numerous past nucleosynthetic events, each characterized by a distinct isotopic signature. We show that the isotopic compositions of elements spanning a large mass range in the earliest formed solids in our Solar System, calcium-aluminum-rich inclusions (CAIs), are uniform, and yet distinct from the average Solar System composition. Relative to younger objects in the Solar System, CAIs contain positive r-process anomalies in isotopes A 140. This fundamental difference in the isotopic character of CAIs around mass 140 necessitates (i) the existence of multiple sources for r-process nucleosynthesis and (ii) the injection of supernova material into a reservoir untapped by CAIs. A scenario of late supernova injection into the protoplanetary disk is consistent with formation of our Solar System in an active star-forming region of the galaxy.

  10. Are collapsars responsible for some r-process elements? How could we tell?

    Energy Technology Data Exchange (ETDEWEB)

    Pruet, J

    2004-04-05

    We consider the possibility that supernovae which form hyper-accreting black holes might be responsible for synthesis of r-process elements with mass A {approx}< 130. Calculations are presented which show that these elements are naturally synthesized in neutron-rich magnetically-dominated bubbles born in the inner regions of a black hole accretion disk. Simple considerations suggest that the total mass ejected in the form of these bubbles is about that needed to account for the entire galactic inventory of the 2nd-peak r-process elements. We also argue that if collapsars are responsible for, e.g., Ag synthesis, then Ag abundances should be correlated with Sc and/or Zn abundances in metal-poor stars.

  11. Loss-Gain Equalized Reconfigurable Phaser for Dynamic Radio Analog Signal Processing (R-ASP)

    CERN Document Server

    Zou, Lianfeng; Caloz, Christophe

    2015-01-01

    We present a loss-gain equalized reconfigurable phaser for dynamic radio analog signal processing (R-ASP). Such a phaser provides real-time tunable group delay response with all-pass transmission. We propose a lumped loss-gain implementation, where tuning and equalization are mostly easily achieved. A theoretical study derives the transfer function and the fundamental characteristics of the device. The phaser is finally experimentally demonstrated, first using a single loss-gain pair and finally a three cascaded loss-gain pair structure with full reconfigurability , where up-chirp and down-chirp group delays are shown for illustration. It is expected that this phaser will find wide applications in radio analog signal processing (R-ASP) systems requiring dynamic adaptability.

  12. Collective Flavor Oscillations Of Supernova Neutrinos and r-Process Nucleosynthesis

    CERN Document Server

    Chakraborty, Sovan; Goswami, Srubabati; Kar, Kamales

    2009-01-01

    Neutrino-neutrino interactions inside core-collapse supernovae may give rise to flavor oscillations resulting into collective swap of flavors. These oscillations depend on the initial energy spectra and initial relative fluxes or initial luminosities of the neutrinos. It has been observed that departure from energy equipartition among different flavors can give rise to one or more sharp spectral swap over energy termed as splits. We study the occurrence of splits in the neutrino and antineutrino spectra varying the initial relative fluxes for different models of initial energy spectrum in both normal and inverted hierarchy. These initial relative flux variations give rise to several possible split patterns where as variation over different models of energy spectra give similar results. We explore the effect of these spectral splits on the electron fraction, $Y_e$, that governs r-process nucleosynthesis inside supernovae. Assuming the condition $Y_e < 0.5$, needed for successful r-process nucleosynthesis we...

  13. {beta}-delayed neutron emission measurements around the third r-process abundance peak

    Energy Technology Data Exchange (ETDEWEB)

    Caballero-Folch, R.; Cortes, G.; Calvino, F.; Gomez-Hornillos, M. B.; Riego, A. [INTE-DFEN, Universitat Politecnica de Catalunya, Barcelona (Spain); Domingo-Pardo, C.; Tain, J. L.; Agramunt, J.; Rubio, B. [IFIC, CSIC-University of Valencia, Valencia (Spain); Algora, A. [IFIC, CSIC-University of Valencia, Valencia (Spain) and Inst. Nucl. Research, Debrecen (Hungary); Ameil, F.; Farinon, F.; Heil, M.; Knoebel, R.; Kojouharov, I.; Kurcewicz, J.; Kurz, N.; Litvinov, Y.; Mukha, I.; Nociforo, C. [GSI, Darmstadt (Germany); and others

    2013-06-10

    This contribution summarizes an experiment performed at GSI (Germany) in the neutron-rich region beyond N=126. The aim of this measurement is to provide the nuclear physics input of relevance for r-process model calculations, aiming at a better understanding of the third r-process abundance peak. Many exotic nuclei were measured around {sup 211}Hg and {sup 215}Tl. Final ion identification diagrams are given in this contribution. For most of them, we expect to derive halflives and and {beta}-delayed neutron emission probabilities. The detectors used in this experiment were the Silicon IMplantation and Beta Absorber (SIMBA) detector, based on an array of highly segmented silicon detectors, and the BEta deLayEd Neutron (BELEN) detector, which consisted of 30 3He counters embedded in a polyethylene matrix.

  14. Phenopix: a R package to process digital images of a vegetation cover

    Science.gov (United States)

    Filippa, Gianluca; Cremonese, Edoardo; Migliavacca, Mirco; Galvagno, Marta; Morra di Cella, Umberto; Richardson, Andrew

    2015-04-01

    Plant phenology is a globally recognized indicator of the effects of climate change on the terrestrial biosphere. Accordingly, new tools to automatically track the seasonal development of a vegetation cover are becoming available and more and more deployed. Among them, near-continuous digital images are being collected in several networks in the US, Europe, Asia and Australia in a range of different ecosystems, including agricultural lands, deciduous and evergreen forests, and grasslands. The growing scientific interest in vegetation image analysis highlights the need of easy to use, flexible and standardized processing techniques. In this contribution we illustrate a new open source package called "phenopix" written in R language that allows to process images of a vegetation cover. The main features include: (i) define of one or more areas of interest on an image and process pixel information within them, (ii) compute vegetation indexes based on red green and blue channels, (iii) fit a curve to the seasonal trajectory of vegetation indexes and extract relevant dates (aka thresholds) on the seasonal trajectory; (iv) analyze image pixels separately to extract spatially explicit phenological information. The utilities of the package will be illustrated in detail for two subalpine sites, a grassland and a larch stand at about 2000 m in the Italian Western Alps. The phenopix package is a cost free and easy-to-use tool that allows to process digital images of a vegetation cover in a standardized, flexible and reproducible way. The software is available for download at the R forge web site (r-forge.r-project.org/projects/phenopix/).

  15. Advanced LIGO Constraints on Neutron Star Mergers and r-process Sites

    Science.gov (United States)

    Côté, Benoit; Belczynski, Krzysztof; Fryer, Chris L.; Ritter, Christian; Paul, Adam; Wehmeyer, Benjamin; O’Shea, Brian W.

    2017-02-01

    The role of compact binary mergers as the main production site of r-process elements is investigated by combining stellar abundances of Eu observed in the Milky Way, galactic chemical evolution (GCE) simulations, and binary population synthesis models, and gravitational wave measurements from Advanced LIGO. We compiled and reviewed seven recent GCE studies to extract the frequency of neutron star–neutron star (NS–NS) mergers that is needed in order to reproduce the observed [Eu/Fe] versus [Fe/H] relationship. We used our simple chemical evolution code to explore the impact of different analytical delay-time distribution functions for NS–NS mergers. We then combined our metallicity-dependent population synthesis models with our chemical evolution code to bring their predictions, for both NS–NS mergers and black hole–neutron star mergers, into a GCE context. Finally, we convolved our results with the cosmic star formation history to provide a direct comparison with current and upcoming Advanced LIGO measurements. When assuming that NS–NS mergers are the exclusive r-process sites, and that the ejected r-process mass per merger event is 0.01 M {}ȯ , the number of NS–NS mergers needed in GCE studies is about 10 times larger than what is predicted by standard population synthesis models. These two distinct fields can only be consistent with each other when assuming optimistic rates, massive NS–NS merger ejecta, and low Fe yields for massive stars. For now, population synthesis models and GCE simulations are in agreement with the current upper limit (O1) established by Advanced LIGO during their first run of observations. Upcoming measurements will provide an important constraint on the actual local NS–NS merger rate, will provide valuable insights on the plausibility of the GCE requirement, and will help to define whether or not compact binary mergers can be the dominant source of r-process elements in the universe.

  16. Large-scale calculations of the beta-decay rates and r-process nucleosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Borzov, I.N.; Goriely, S. [Inst. d`Astronomie et d`Astrophysique, Univ. Libre de Bruxelles, Campus Plaine, Bruxelles (Belgium); Pearson, J.M. [Inst. d`Astronomie et d`Astrophysique, Univ. Libre de Bruxelles, Campus Plaine, Bruxelles (Belgium)]|[Lab. de Physique Nucleaire, Univ. de Montreal, Montreal (Canada)

    1998-06-01

    An approximation to a self-consistent model of the ground state and {beta}-decay properties of neutron-rich nuclei is outlined. The structure of the {beta}-strength functions in stable and short-lived nuclei is discussed. The results of large-scale calculations of the {beta}-decay rates for spherical and slightly deformed nuclides of relevance to the r-process are analysed and compared with the results of existing global calculations and recent experimental data. (orig.)

  17. Solar r-process-constrained actinide production in neutrino-driven winds of supernovae

    Science.gov (United States)

    Goriely, S.; Janka, H.-Th.

    2016-07-01

    Long-lived radioactive nuclei play an important role as nucleo-cosmochronometers and as cosmic tracers of nucleosynthetic source activity. In particular, nuclei in the actinide region like thorium, uranium, and plutonium can testify to the enrichment of an environment by the still enigmatic astrophysical sources that are responsible for the production of neutron-rich nuclei by the rapid neutron-capture process (r-process). Supernovae and merging neutron-star (NS) or NS-black hole binaries are considered as most likely sources of the r-nuclei. But arguments in favour of one or the other or both are indirect and make use of assumptions; they are based on theoretical models with remaining simplifications and shortcomings. An unambiguous observational determination of a production event is still missing. In order to facilitate searches in this direction, e.g. by looking for radioactive tracers in stellar envelopes, the interstellar medium or terrestrial reservoirs, we provide improved theoretical estimates and corresponding uncertainty ranges for the actinide production (232Th, 235, 236, 238U, 237Np, 244Pu, and 247Cm) in neutrino-driven winds of core-collapse supernovae. Since state-of-the-art supernova models do not yield r-process viable conditions - but still lack, for example, the effects of strong magnetic fields - we base our investigation on a simple analytical, Newtonian, adiabatic and steady-state wind model and consider the superposition of a large number of contributing components, whose nucleosynthesis-relevant parameters (mass weight, entropy, expansion time-scale, and neutron excess) are constrained by the assumption that the integrated wind nucleosynthesis closely reproduces the Solar system distribution of r-process elements. We also test the influence of uncertain nuclear physics.

  18. Complete Element Abundances of Nine Stars in the r-process Galaxy Reticulum II

    Science.gov (United States)

    Ji, Alexander P.; Frebel, Anna; Simon, Joshua D.; Chiti, Anirudh

    2016-10-01

    We present chemical abundances derived from high-resolution Magellan/Magellan Inamori Kyocera Echelle spectra of the nine brightest known red giant members of the ultra-faint dwarf galaxy Reticulum II (Ret II). These stars span the full metallicity range of Ret II (‑3.5 date. The other two stars are the most metal-poor stars in the system ([Fe/H] up to the iron peak are otherwise similar to abundances of stars in the halo and in other ultra-faint dwarf galaxies. However, the scatter in abundance ratios is large enough to suggest that inhomogeneous metal mixing is required to explain the chemical evolution of this galaxy. The presence of low amounts of neutron-capture elements in other ultra-faint dwarf galaxies may imply the existence of additional r-process sites besides the source of r-process elements in Ret II. Galaxies like Ret II may be the original birth sites of r-process enhanced stars now found in the halo. This paper includes data gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile.

  19. Transport and mixing of r-process elements in neutron star binary merger blast waves

    CERN Document Server

    Montes, Gabriela; Naiman, Jill; Shen, Sijing; Lee, William H

    2016-01-01

    The r-process nuclei are robustly synthesized in the material ejected during a neutron star binary merger (NSBM), as tidal torques transport angular momentum and energy through the outer Lagrange point in the form of a vast tidal tail. If NSBM are indeed solely responsible for the solar system r- process abundances, a galaxy like our own would require to host a few NSBM per million years, with each event ejecting, on average, about 5x10^{-2} M_sun of r-process material. Because the ejecta velocities in the tidal tail are significantly larger than in ordinary supernovae, NSBM deposit a comparable amount of energy into the interstellar medium (ISM). In contrast to extensive efforts studying spherical models for supernova remnant evolution, calculations quantifying the impact of NSBM ejecta in the ISM have been lacking. To better understand their evolution in a cosmological context, we perform a suite of three-dimensional hydrodynamic simulations with optically-thin radiative cooling of isolated NSBM ejecta expa...

  20. Collective flavor oscillations of supernova neutrinos and r-process nucleosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Chakraborty, Sovan; Kar, Kamales [Saha Institute of Nuclear Physics, 1/AF Bidhannagar, Kolkata 700064 (India); Choubey, Sandhya [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211019 (India); Goswami, Srubabati, E-mail: sovan.chakraborty@saha.ac.in, E-mail: sandhya@hri.res.in, E-mail: sruba@prl.res.in, E-mail: kamales.kar@saha.ac.in [Physical Research Laboratory, Navrangpura, Ahmedabad 380009 (India)

    2010-06-01

    Neutrino-neutrino interactions inside core-collapse supernovae may give rise to collective flavor oscillations resulting in swap between flavors. These oscillations depend on the initial energy spectra, and relative fluxes or relative luminosities of the neutrinos. It has been observed that departure from energy equipartition among different flavors can give rise to one or more sharp spectral swap over energy, termed as splits. We study the occurrence of splits in the neutrino and antineutrino spectra, varying the initial relative fluxes for different models of initial energy spectrum, in both normal and inverted hierarchy. These initial relative flux variations give rise to several possible split patterns whereas variation over different models of energy spectra give similar results. We explore the effect of these spectral splits on the electron fraction, Y{sub e}, that governs r-process nucleosynthesis inside supernovae. Since spectral splits modify the electron neutrino and antineutrino spectra in the region where r-process is postulated to happen, and since the pattern of spectral splits depends on the initial conditions of the spectra and the neutrino mass hierarchy, we show that the condition Y{sub e} < 0.5 required for successful r-process nucleosynthesis will lead to constraints on the initial spectral conditions, for a given neutrino mass hierarchy.

  1. r-Process enrichment by magnetorotational core-collapse supernovae in the early dwarf spheroidal galaxies

    CERN Document Server

    Tsujimoto, Takuji

    2015-01-01

    One of the hottest open issues in chemical evolution of $r$-process elements is fast enrichment in the early Universe. Clear evidence for it is seen in stellar abundances of extremely metal-poor stars in the Galactic halo. On the other hand, small-mass galaxies are the ideal testbed to follow the evolutionary features of r-process enrichment, given the potential rarity of production events yielding heavy r-process elements. Their occurrences become countable and thus an enrichment path due to each event can be found in the stellar abundances. We examine the chemical feature of Eu abundance at an early stage of [Fe/H] $\\lesssim -2$ in the Draco and Sculptor dwarf spheroidal (dSph) galaxies. Accordingly we constrain the properties of the Eu production in the early dSphs. We find that the Draco dSph experienced a few Eu production events while Eu enrichment took place more continuously in the Sculptor dSph due to its larger stellar mass. The event rate of Eu production is estimated to be about one per $100-200$ ...

  2. Atomic processes and application in honour of David R. Bates' 60th birthday

    CERN Document Server

    Burke, P G

    2013-01-01

    Atomic Processes and Applications is a collection of review articles that discusses major atomic and molecular processes and their applications to upper atmospheric physics and to astrophysics. The book also serves as a 60th birthday tribute to Dr. David R. Bates. The coverage of the text includes the overview of stratospheric aeronomy; upper atmosphere of the earth; and problems in atmospheric pollution. The book also deals with technical and highly specialized issues including photoionization of atomic systems; atomic structure and oscillator strengths; and atomic scattering computations. Th

  3. Using the ACT-R architecture to specify 39 quantitative process models of decision making

    Directory of Open Access Journals (Sweden)

    Julian N. Marewski

    2011-08-01

    Full Text Available Hypotheses about decision processes are often formulated qualitatively and remain silent about the interplay of decision, memorial, and other cognitive processes. At the same time, existing decision models are specified at varying levels of detail, making it difficult to compare them. We provide a methodological primer on how detailed cognitive architectures such as ACT-R allow remedying these problems. To make our point, we address a controversy, namely, whether noncompensatory or compensatory processes better describe how people make decisions from the accessibility of memories. We specify 39 models of accessibility-based decision processes in ACT-R, including the noncompensatory recognition heuristic and various other popular noncompensatory and compensatory decision models. Additionally, to illustrate how such models can be tested, we conduct a model comparison, fitting the models to one experiment and letting them generalize to another. Behavioral data are best accounted for by race models. These race models embody the noncompensatory recognition heuristic and compensatory models as a race between competing processes, dissolving the dichotomy between existing decision models.

  4. Physics and Process Modeling (PPM) and Other Propulsion R and T. Volume 1; Materials Processing, Characterization, and Modeling; Lifting Models

    Science.gov (United States)

    1997-01-01

    This CP contains the extended abstracts and presentation figures of 36 papers presented at the PPM and Other Propulsion R&T Conference. The focus of the research described in these presentations is on materials and structures technologies that are parts of the various projects within the NASA Aeronautics Propulsion Systems Research and Technology Base Program. These projects include Physics and Process Modeling; Smart, Green Engine; Fast, Quiet Engine; High Temperature Engine Materials Program; and Hybrid Hyperspeed Propulsion. Also presented were research results from the Rotorcraft Systems Program and work supported by the NASA Lewis Director's Discretionary Fund. Authors from NASA Lewis Research Center, industry, and universities conducted research in the following areas: material processing, material characterization, modeling, life, applied life models, design techniques, vibration control, mechanical components, and tribology. Key issues, research accomplishments, and future directions are summarized in this publication.

  5. The r-process in the neutrino-driven wind from a black-hole torus

    CERN Document Server

    Wanajo, Shinya

    2011-01-01

    We examine r-process nucleosynthesis in the neutrino-driven wind from the thick accretion disk (or "torus") around a black hole. Such systems are expected as emnants of binary neutron star or neutron star -- black hole mergers. We consider a simplified, analytic, time-dependent evolution model of a 3M_sun central black hole surrounded by a neutrino emitting accretion torus with 90km radius, which serves as basis for computing spherically symmetric neutrino-driven wind solutions. We find that ejecta with modest entropies (~30 per nucleon in units of the Boltzmann constant) and moderate expansion timescales (~100ms) dominate in the mass outflow. The mass-integrated nucleosynthetic abundances are in good agreement with the solar system r-process abundance distribution if a minimal value of the electron fraction at the charged-particle freezeout, Ye,min~0.2, is achieved. In the case of Ye,min~0.3, the production of r-elements beyond A~130 does not reach to the third peak but could be still important for an explan...

  6. The final step in 5.8S rRNA processing is cytoplasmic in Saccharomyces cerevisiae.

    Science.gov (United States)

    Thomson, Emma; Tollervey, David

    2010-02-01

    The 18S rRNA component of yeast (Saccharomyces cerevisiae) 40S ribosomes undergoes cytoplasmic 3' cleavage following nuclear export, whereas exported pre-60S subunits were believed to contain only mature 5.8S and 25S rRNAs. However, in situ hybridization detected 3'-extended forms of 5.8S rRNA in the cytoplasm, which were lost when Crm1-dependent preribosome export was blocked by treatment with leptomycin B (LMB). LMB treatment rapidly blocked processing of 6S pre-rRNA to 5.8S rRNA, leading to TRAMP-dependent pre-rRNA degradation. The 6S pre-rRNA was coprecipitated with the 60S export adapter Nmd3 and cytoplasmic 60S synthesis factor Lsg1. The longer 5.8S+30 pre-rRNA (a form of 5.8S rRNA 3' extended by approximately 30 nucleotides) is processed to 6S by the nuclear exonuclease Rrp6, and nuclear pre-rRNA accumulated in the absence of Rrp6. In contrast, 6S to 5.8S processing requires the cytoplasmic exonuclease Ngl2, and cytoplasmic pre-rRNA accumulated in strains lacking Ngl2. We conclude that nuclear pre-60S particles containing the 6S pre-rRNA bind Nmd3 and Crm1 and are exported to the cytoplasm prior to final maturation by Ngl2.

  7. The Final Step in 5.8S rRNA Processing Is Cytoplasmic in Saccharomyces cerevisiae▿ †

    Science.gov (United States)

    Thomson, Emma; Tollervey, David

    2010-01-01

    The 18S rRNA component of yeast (Saccharomyces cerevisiae) 40S ribosomes undergoes cytoplasmic 3′ cleavage following nuclear export, whereas exported pre-60S subunits were believed to contain only mature 5.8S and 25S rRNAs. However, in situ hybridization detected 3′-extended forms of 5.8S rRNA in the cytoplasm, which were lost when Crm1-dependent preribosome export was blocked by treatment with leptomycin B (LMB). LMB treatment rapidly blocked processing of 6S pre-rRNA to 5.8S rRNA, leading to TRAMP-dependent pre-rRNA degradation. The 6S pre-rRNA was coprecipitated with the 60S export adapter Nmd3 and cytoplasmic 60S synthesis factor Lsg1. The longer 5.8S+30 pre-rRNA (a form of 5.8S rRNA 3′ extended by ∼30 nucleotides) is processed to 6S by the nuclear exonuclease Rrp6, and nuclear pre-rRNA accumulated in the absence of Rrp6. In contrast, 6S to 5.8S processing requires the cytoplasmic exonuclease Ngl2, and cytoplasmic pre-rRNA accumulated in strains lacking Ngl2. We conclude that nuclear pre-60S particles containing the 6S pre-rRNA bind Nmd3 and Crm1 and are exported to the cytoplasm prior to final maturation by Ngl2. PMID:20008552

  8. Crosstalk in gene expression: coupling and co-regulation of rDNA transcription, pre-ribosome assembly and pre-rRNA processing.

    Science.gov (United States)

    Granneman, Sander; Baserga, Susan J

    2005-06-01

    Ribosomes, the large RNPs that translate mRNA into protein in the cytoplasm of eukaryotic cells, are synthesized in a subcompartment of the nucleus, the nucleolus. There, transcription by Pol I yields a pre-rRNA which is modified, cleaved and assembled with ribosomal proteins to make functional ribosomes. Previously, rRNA transcription and pre-rRNA cleavage in eukaryotes were considered to be separable steps in gene expression. However, recent findings suggest that these two steps in gene expression can be concurrent and are co-regulated. Unexpectedly, optimal rDNA transcription requires the presence of a defined subset of components of the pre-rRNA processing machinery.

  9. s- and r-process elements in two very metal-poor stars

    CERN Document Server

    Ryan, S G; Blake, L A J; Norris, J E; Beers, T C; Gallino, R; Busso, M; Ando, H; Ryan, Sean G.; Aoki, Wako; Blake, Lisa A. J.; Norris, John E.; Beers, Timothy C.; Gallino, Roberto; Busso, Maurizio; Ando, Hiroyasu

    2000-01-01

    New measurements of neutron-capture elements are presented for two very metal-poor stars ([Fe/H] ~ -3). One (LP 625-44) has an s-process signature believed to be due to mass transfer from a now-extinct metal-poor AGB companion, and the second (CS 22897-008) is one of a number of very metal-poor stars having high [Sr/Ba] ratios which is not expected from the r-process. In the s-process star, many elements including lead have been detected, providing strong constraints on the 13C pocket in the now-extinct AGB star. In the Sr-rich star, Zn, Y, and Zr are also seen to be overabundant, and several possible nucleosynthesis mechanisms are discussed.

  10. rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism

    Directory of Open Access Journals (Sweden)

    Estate M Sokhadze

    2014-08-01

    Full Text Available Objectives: Reports in autism spectrum disorders (ASD of a minicolumnopathy with consequent deficits of lateral inhibition help explain observed behavioral and executive dysfunctions. We propose that neuromodulation based on rTMS will enhance lateral inhibition through activation of inhibitory double bouquet interneurons and will be accompanied by improvements in the prefrontal executive functions. Methods: The current study used ERPs in a visual oddball task with illusory figures. We compared clinical, behavioral and electrocortical outcomes in 2 groups of children with autism (TMS, wait-list group [WTL]. We predicted that 18 session long course in autistic patients will have better behavioral and ERP outcomes as compared to age- and IQ-matched wait-list group. We used 18 sessions of 1Hz rTMS applied over the dorso-lateral prefrontal cortex in 27 individuals with ASD diagnosis. The WTL group was comprised of 27 age-matched ASD subjects. Results: Post-TMS evaluations showed decreased irritability and hyperactivity and decreased stereotypic behaviors. Following rTMS we found decreased amplitude and prolonged latency in the fronto-central ERPs to non-targets in the TMS group. These ERP changes along with increased centro-parietal ERPs to targets are indicative of more efficient processing of information post-TMS. Another finding was increased magnitude of error-related negativity (ERN during commission errors. We calculated normative post-error reaction time (RT slowing response in both groups and found that rTMS was accompanied by post-error RT slowing and higher accuracy of responses, whereas the WTL group kept on showing typical for ASD post-error RT speeding and had higher error rate. Conclusion: Results from our study indicate that rTMS improves executive functioning in ASD as evidenced by normalization of ERP responses and behavioral reactions during executive function test, and also by improvements in clinical behavioral evaluations.

  11. Management von Article Processing Charges - Herausforderungen für Bibliotheken

    Directory of Open Access Journals (Sweden)

    Kai Geschuhn

    2015-03-01

    Full Text Available Seit mehreren Jahren betreiben Hochschulbibliotheken Publikationsfonds, um Open-Access-Artikelgebühren, Article Processing Charges, für die Autorinnen und Autoren ihrer Einrichtungen zu übernehmen. Der dynamische Anstieg der Open-Access-Publikationen in den letzten Jahren wirft die Frage auf, ob die derzeitigen Verfahren zwischen Verlagen und wissenschaftlichen Einrichtungen stabil genug sind und bei einer vollständigen Umstellung auf Open Access skalieren. Die Max Planck Digital Library übernimmt derzeit jährlich zentral Gebühren für etwa 600 Open-Access-Artikel aus der Max-Planck-Gesellschaft. Der Beitrag gibt einen Überblick über die strategischen Hintergründe dieser zentralen Kostenübernahme und zeigt anschließend die einzelnen Prozessschritte sowie die Hürden hierbei auf. Die größten Desiderate im Hinblick auf die Etablierung effizienter und nachhaltiger Prozesse sind optimierte Artikel-Einreichungssysteme, eine bessere Autorenidentifizierung sowie ein vereinheitlichtes, verbessertes Reporting. Dedicated funds for Open Access publishing have been a strategic instrument at German university libraries for some years. The dynamically growing number of Open Access publications raises the question whether the processes for handling article processing charges (APC between libraries and publishers are organized sustainably enough to support a full transition to Open Access. On behalf of Max Planck researchers, the Max Planck Digital Library centrally processes about 600 invoices for Open Access articles per year. This paper explains the strategic background and also describes the individual steps which are necessary for assuming charges centrally and the barriers which can emerge during this process. In order to establish smooth and scalable processes, the main desiderata are the optimization of article submitting systems, a better author identification and allocation, and improved reporting.

  12. Puzzling Origin of CEMP-r/s Stars: An Interpretation of Abundance and Enrichment of s- and r-Process Elements from Asymptotic Giant Branch Supernovae

    Indian Academy of Sciences (India)

    Jiang Zhang; Fang Zhao; Yanping Chen; Wenyuan Cui; Bo Zhang

    2013-12-01

    CEMP-r/s stars at low metallicity are known as double-enhanced stars that show enhancements of both r-process and s-process elements. The chemical abundances of these very metal-poor stars provide us a lot of information for putting new restraints on models of neutron-capture processes. In this article, we put forward an accreted scenario in which the double enrichment of r-process and s-process elements is caused by a former intermediate-mass Asymptotic Giant Branch (AGB) companion in a detached binary system. As the AGB superwind is only present at the ultimate phase of AGB stars, there is thus a lot of potential that the degenerate-core mass of an intermediate-mass AGB star reaches the Chandrasekhar limit before the AGB superwind. In these circumstances, both s-process elements produced in the AGB shell and r-process elements synthesized in the subsequent explosion would be sprayed contemporaneously and accreted by its companion. Despite similarity to physical conditions of a core-collapse supernova, a major focus in this scenario is the degenerate C–O core surrounded by an envelope of a former intermediate-mass AGB donor that may collapse and explode. Due to the existence of an outer envelope, r-process nucleosynthesis is expected to occur. Hypothesizing the material-rich europium (Eu) accreted by the secondary via the wind from the supernova to be in proportion to the geometric fraction of the companion with respect to the exploding donor star, we find that the estimated yield of Eu (as representative of r-process elements) per AGB supernova event is about 1 × 10-9⊙ ∼ 5 × 10-9⊙. Using the yields of Eu, the overabundance of r-process elements in CEMP-r/s stars can be accounted for. The calculated results show that the value of parameter , standing for efficiency of wind pollution from the AGB supernova, will reach about 104, which means that the enhanced factor is much larger than unity due to the impact of gravity of the donor and the result of the

  13. Enabling Web-Based Analysis of CUAHSI HIS Hydrologic Data Using R and Web Processing Services

    Science.gov (United States)

    Ames, D. P.; Kadlec, J.; Bayles, M.; Seul, M.; Hooper, R. P.; Cummings, B.

    2015-12-01

    The CUAHSI Hydrologic Information System (CUAHSI HIS) provides open access to a large number of hydrological time series observation and modeled data from many parts of the world. Several software tools have been designed to simplify searching and access to the CUAHSI HIS datasets. These software tools include: Desktop client software (HydroDesktop, HydroExcel), developer libraries (WaterML R Package, OWSLib, ulmo), and the new interactive search website, http://data.cuahsi.org. An issue with using the time series data from CUAHSI HIS for further analysis by hydrologists (for example for verification of hydrological and snowpack models) is the large heterogeneity of the time series data. The time series may be regular or irregular, contain missing data, have different time support, and be recorded in different units. R is a widely used computational environment for statistical analysis of time series and spatio-temporal data that can be used to assess fitness and perform scientific analyses on observation data. R includes the ability to record a data analysis in the form of a reusable script. The R script together with the input time series dataset can be shared with other users, making the analysis more reproducible. The major goal of this study is to examine the use of R as a Web Processing Service for transforming time series data from the CUAHSI HIS and sharing the results on the Internet within HydroShare. HydroShare is an online data repository and social network for sharing large hydrological data sets such as time series, raster datasets, and multi-dimensional data. It can be used as a permanent cloud storage space for saving the time series analysis results. We examine the issues associated with running R scripts online: including code validation, saving of outputs, reporting progress, and provenance management. An explicit goal is that the script which is run locally should produce exactly the same results as the script run on the Internet. Our design can

  14. Approaching the precursor nuclei of the third r-process peak with RIBs

    CERN Document Server

    Domingo-Pardo, C; Agramunt, J.; Algora, A.; Arcones, A.; Ameil, F.; Ayyad, Y.; Benlliure, J.; Bowry, M.; Calvino, F.; Cano-Ott, D.; Cortes, G.; Davinson, T.; Dillmann, I.; Estrade, A.; Evdokimov, A.; Faestermann, T.; Farinon, F.; Galaviz, D.; Garcia-Rios, A.; Geissel, H.; Gelletly, W.; Gernhauser, R.; Gomez-Hornillos, M.B.; Guerrero, C.; Heil, M.; Hinke, C.; Knobel, R.; Kojouharov, I.; Kurcewicz, J.; Kurz, N.; Litvinov, Y.; Maier, L.; Marganiec, J.; Marta, M.; Martinez, T.; Martinez-Pinedo, G.; Meyer, B.S.; Montes, F.; Mukha, I.; Napoli, D.R.; Nociforo, Ch.; Paradela, C.; Pietri, S.; Podolyak, Z.; Prochazka, A.; Rice, S.; Riego, A.; Rubio, B.; Schaffner, H.; Scheidenberger, Ch.; Smith, K.; Sokol, E.; Steiger, K.; Sun, B.; Tain, J.L.; Takechi, M.; Testov, D.; Weick, H.; Wilson, E.; Winfield, J.S.; Wood, R.; Woods, P.; Yeremin, A.

    2013-01-01

    The rapid neutron nucleosynthesis process involves an enormous amount of very exotic neutron-rich nuclei, which represent a theoretical and experimental challenge. Two of the main decay properties that affect the final abundance distribution the most are half-lives and neutron branching ratios. Using fragmentation of a primary $^{238}$U beam at GSI we were able to measure such properties for several neutron-rich nuclei from $^{208}$Hg to $^{218}$Pb. This contribution provides a short update on the status of the data analysis of this experiment, together with a compilation of the latest results published in this mass region, both experimental and theoretical. The impact of the uncertainties connected with the beta-decay rates and with beta-delayed neutron emission is illustrated on the basis of $r$-process network calculations. In order to obtain a reasonable reproduction of the third $r$-process peak, it is expected that both half-lives and neutron branching ratios are substantially smaller, than those based ...

  15. The History of R-Process Enrichment in the Milky Way

    CERN Document Server

    Shen, Sijing; Ramirez-Ruiz, Enrico; Madau, Piero; Mayer, Lucio; Guedes, Javiera

    2014-01-01

    We investigate the production sites and the enrichment history of r-process elements in the Galaxy, as traced by the [Eu/Fe] ratio, using the high resolution, cosmological zoom-in simulation `Eris'. At z=0, Eris represents a close analog to the Milky Way, making it the ideal laboratory to understand the chemical evolution of our Galaxy. Eris formally traces the production of $\\alpha$-capture and Fe-peak elements due to Type Ia and Type II supernovae. We include in post-processing the production of r-process elements from either Type II supernovae or compact binary mergers. Unlike previous studies, we find that the nucleosynthetic products from compact binary mergers can be incorporated into stars of very low metallicity and at early times, even with a minimum delay time of 100 Myr. This conclusion is relatively insensitive to modest variations in the merger rate and delay time distribution. By implementing a first-order prescription for metal-mixing, we can further improve the agreement between our model and ...

  16. Chemical evolution of 244Pu in the solar vicinity and its implications for the properties of r-process production

    Science.gov (United States)

    Tsujimoto, Takuji; Yokoyama, Tetsuya; Bekki, Kenji

    2017-01-01

    Meteoritic abundances of r-process elements are analyzed to deduce the history of chemical enrichment by the r-process, from the beginning of disk formation to the present time in the solar vicinity. Our analysis combines the abundance information from short-lived radioactive nuclei such as 244Pu with the abundance information from stable r-process nuclei such as Eu. These two types of nuclei can be associated with one r-process event and an accumulation of events until the formation of the solar system, respectively. With the help of the observed local star formation (SF) history, we deduce the chemical evolution of 244Pu and obtain three main results: (i) the last r-process event occurred 130–140 Myr before the formation of the solar system; (ii) the present-day low 244Pu abundance as measured in deep-sea reservoirs results from the low recent SF rate compared to ∼4.5‑5 Gyr ago; and (iii) there were ∼15 r-process events in the solar vicinity from the formation of the Galaxy to the time of solar system’s formation and ∼30 r-process events to the present time. Then, adopting the hypothesis that a neutron star (NS) merger is the r-process production site, we find that the ejected r-process elements are extensively spread out and mixed with interstellar matter, with a mass of ∼ 3.5× {10}6 M⊙, which is about 100 times larger than that for supernova ejecta. In addition, the event frequency of r-process production is estimated to be 1 per ~1400 core-collapse supernovae, which is identical to the frequency of NS mergers estimated from the analysis of stellar abundances.

  17. Planar Reflective Phaser and Synthesis for Radio Analog Signal Processing (R-ASP)

    CERN Document Server

    Zou, Lianfeng; Caloz, Christophe

    2014-01-01

    A planar reflective phaser based on an open-ended edge-coupled-line structure is proposed. This phaser is the first reported phaser that combines the benefits of high resolution, inherent to cross-coupled resonator reflective phasers, and of compactness, inherent to planar circuits. A 4-ns swing 4.9-5.5 GHz quadratic phase (linear group delay) 4th-order microstrip phaser is synthesized and experimentally demonstrated. Given its advantages, this phaser may find vast applications in Radio Analog Signal Processing (R-ASP) systems.

  18. Expected Limits on R-symmetric $\\mu \\to e $ Processes at Project X

    CERN Document Server

    Fok, Ricky

    2012-01-01

    We investigate $\\mu \\to e$ processes in the Minimal R-symmetric Standrad Model (MRSSM) with the expected limits from Project X. It is found that $\\mu \\to e$ conversion provides the tightest bound on the $\\mu \\to e$ mixing parameters at the order of $\\lesssim O(10^{-3})$. Whereas $\\mu \\to eee$ only slightly improves the bound in the region where incoherence among different contributions to $\\mu \\to e$ is significant. No improvements on the bounds are obtained from $\\mu \\to e \\gamma$.

  19. Single Neutron Transfer Experiments Close to the r-Process Path

    Energy Technology Data Exchange (ETDEWEB)

    Grzywacz-Jones, Kate L [ORNL; Adekola, Aderemi S [ORNL; Bardayan, Daniel W [ORNL; Blackmon, Jeff C [ORNL; Chae, Kyung Yuk [ORNL; Chipps, K. [Colorado School of Mines, Golden; Cizewski, Jolie [ORNL; Dean, David Jarvis [ORNL; Erikson, Luke [Colorado School of Mines, Golden; Fitzgerald, R. P. [University of North Carolina, Chapel Hill; Gaddis, A. L. [Furman University; Greife, U. [Colorado School of Mines, Golden; Harlin, Christopher W [ORNL; Hatarik, Robert [Rutgers University; Howard, Joshua A [ORNL; Johnson, Micah [ORNL; Kozub, R. L. [Tennessee Technological University; Liang, J Felix [ORNL; Livesay, Jake [ORNL; Ma, Zhanwen [ORNL; Moazen, Brian [University of Tennessee, Knoxville (UTK); O' Malley, Patrick [Rutgers University; Nesaraja, Caroline D [ORNL; Pain, S. D. [Rutgers University; Patterson, N. P. [University of Surrey, UK; Paulauskas, Stanley V [ORNL; Shapira, Dan [ORNL; ShrinerJr., J. F. [Tennessee Technological University; Sissom, D. J. [Tennessee Technological University; Smith, Michael Scott [ORNL; Swan, T. P. [University of Surrey, UK; Thomas, J. S. [Rutgers University

    2007-01-01

    The first measurements using the (d, p) transfer reaction to study single- particle states in nuclei on the expected r-process path have been made at the Holifield Radioactive Ion Beam Facility. The shell closure at N = 50 has been crossed using the 82Ge(d, p) and 84Se(d, p) reactions. The prop- erties of the lowest-lying states have been determined. Furthermore, the 132Sn(d, p) reaction has been used for the first time to populate single- particle states in 133Sn.

  20. R-process Nucleosynthesis during the Magnetohydrodynamics Explosions of a Massive Star

    CERN Document Server

    Saruwatari, Motoaki; Kotake, Kei; Yamada, Shoichi

    2012-01-01

    We investigate the possibility of the r-process during the magnetohydrohynamical explosion of supernova in a massive star of 13 solar mass with the effects of neutrinos induced. We adopt five kinds of initial models which include properties of rotation and the toroidal component of the magnetic field . The simulations which succeed the explosions are limitted to a concentrated magnetic field and strong differential rotation. Low $Y_{e}$ ejecta produce heavy elements and the third peak can be reprocuced. However, the second peak is low because $Y_{e}$ distribution as a function of radius is steep and ejecta corresponding to middle $Y_{e}$ is very few.

  1. rTMS neuromodulation improves electrocortical functional measures of information processing and behavioral responses in autism

    Science.gov (United States)

    Sokhadze, Estate M.; El-Baz, Ayman S.; Sears, Lonnie L.; Opris, Ioan; Casanova, Manuel F.

    2014-01-01

    changes along with increased centro-parietal P100 and P300 (P3b) to targets are indicative of more efficient processing of information post-TMS treatment. Another important finding was decrease of the latency and increase of negativity of error-related negativity (ERN) during commission errors that may reflect improvement in error monitoring and correction function. Enhanced information processing was also manifested in lower error rate. In addition we calculated normative post-error treaction time (RT) slowing response in both groups and found that rTMS treatment was accompanied by post-error RT slowing and higher accuracy of responses, whereas the WTL group kept on showing typical for ASD post-error RT speeding and higher commission and omission error rates. Conclusion: Results from our study indicate that rTMS improves executive functioning in ASD as evidenced by normalization of ERP responses and behavioral reactions (RT, accuracy) during executive function test, and also by improvements in clinical evaluations. PMID:25147508

  2. The Final Step in 5.8S rRNA Processing Is Cytoplasmic in Saccharomyces cerevisiae▿ †

    OpenAIRE

    Thomson, Emma; TOLLERVEY, DAVID

    2009-01-01

    The 18S rRNA component of yeast (Saccharomyces cerevisiae) 40S ribosomes undergoes cytoplasmic 3' cleavage following nuclear export, whereas exported pre-60S subunits were believed to contain only mature 5.8S and 25S rRNAs. However, in situ hybridization detected 3'-extended forms of 5.8S rRNA in the cytoplasm, which were lost when Crm1-dependent preribosome export was blocked by treatment with leptomycin B (LMB). LMB treatment rapidly blocked processing of 6S pre-rRNA to 5.8S rRNA, leading t...

  3. Constraints on the Nature of the s- and r-processes

    Science.gov (United States)

    Sneden, Christopher; Cowan, John J.; Gallino, Roberto

    2010-03-01

    Neutron-capture (Z > 30) elements are detected in many very metal-poor halo stars, and so they must have been manufactured by some of the earliest element donors in our Galaxy's history. The bulk amounts of neutron-capture elements with respect to the iron group vary by several orders of magnitude from star to star at low metallicities. Additionally, abundance distributions among these elements are often strikingly different from that of the solar system. Some stars exhibit abundances that must have been made purely in “rapid” neutron-capture events (the r-process), some in “slow” events (the s-process), and some have hybrid mixes. Here we summarize the major observed categories of the neutron-capture abundances in metal-poor stars, and discuss their implications for early Galactic nucleosynthesis.

  4. Mass measurements beyond the major r-process waiting point $^{80}$Zn

    CERN Document Server

    Baruah, S; Blaum, K; Dworschak, M; George, S; Guenaut, C; Hager, U; Herfurth, F; Herlert, A; Kellerbauer, A G; Kluge, H J; Lunney, D; Schatz, H; Schweikhard, L; Yazidjian, C

    2008-01-01

    High-precision mass measurements on neutron-rich zinc isotopes $^{71m,72-81}$Zn have been performed with the Penning trap mass spectrometer ISOLTRAP. For the first time the mass of $^{81}$Zn has been experimentally determined. This makes $^{80}$Zn the first of the few major waiting points along the path of the astrophysical rapid neutron capture process where neutron separation energy and neutron capture $Q$-value are determined experimentally. As a consequence, the astrophysical conditions required for this waiting point and its associated abundance signatures to occur in $r$-process models can now be mapped precisely. The measurements also confirm the robustness of the $N = 50$ shell closure for $Z = 30$ farther from stability.

  5. Abundance of Weak r-Process Elements of Metal-Poor Stars ˜Universality or Diversity?˜

    Science.gov (United States)

    Aoki, Misa; Ishimaru, Yuhri; Aoki, Wako; Wanajo, Shinya

    The origin of the rapid neutron-capture process is a major question in astrophysics. The key to this question is the chemical abundance patterns of very metal-poor stars (VMP), which are believed to reflect the nucleosynthesis yields of single event. Recent observations of VMP indicate that there are at least two components to r-process; "main r-process" responsible for relatively heavy neutron-capture elements and "weak r-process" [1] responsible for relatively light neutron-capture elements. The VMP with heavier neutron-capture elements are known to have similar pattern to that of solar r-process, suggesting universality in main r-process nucleosynthesis [2]. A question is whether weak r-process also show such universality. We present the abundance analysis of neutron-capture elements in five stars (HD107752, HD110184, HD85773, HD23798, BD+6 648) in the Galactic halo observed by the Subaru Telescope High Dispersion Spectrograph. Their light neutron-capture elements (e.g., Sr, Y) show overabundance, inferring contribution of weak r-process, while heavy neutron-capture elements (e.g., Ba, Eu) are deficient. The overabundance of these stars, however, is not as significant as that found in HD122563 [3] known as the weak r-process star. These results suggests that there is diversity in the nucleosynthesis of the weak r-process. In addition, we compare our results with the latest nucleosynthesis models of electron capture supernova and core collapse supernova [4, 5].

  6. Beta-delayed fission probabilities of transfermium nuclei, involved in the r-process

    Science.gov (United States)

    Panov, I.; Lutostansky, Yu; Thielemann, F.-K.

    2016-01-01

    For the nucleosynthesis of heavy and superheavy nuclei fission becomes very important when the r-process runs in a very high neutron density environment. In part, fission is responsible for the formation of heavy nuclei due to the inclusion of fission products as new seed nuclei (fission cycling). More than that, beta-delayed fission, along with spontaneous fission, is responsible in the late stages of the r-process for the suppression of superheavy element yields. For beta-delayed fission probability calculations a model description of the beta-strength- functions is required. Extended theoretical predictions for astro-physical applications were provided long ago, and new predictions also for superheavy nuclei with uptodate nuclear input are needed. For the further extension of data to heavier transactinides the models of strength- functions should be modified, taking into account more complicated level schemes. In our present calculations the strength-function model is based on the quasi-particle approximation of Finite Fermi Systems Theory. The probabilities of beta-delayed fission and beta-delayed neutron emission are calculated for some transfermium neutron-rich nuclei, and the influence of beta-delayed fission upon superheavy element formation is discussed.

  7. Theoretical neutron-capture cross sections for r-process nucleosynthesis in the $^{48}$Ca region

    CERN Document Server

    Rauscher, T; Kratz, K -L; Balogh, W; Oberhummer, H

    2015-01-01

    We calculate neutron capture cross sections for r-process nucleosynthesis in the $^{48}$Ca region, namely for the isotopes $^{40-44}$S, $^{46-50}$Ar, $^{56-66}$Ti, $^{62-68}$Cr, and $^{72-76}$Fe. While previously only cross sections resulting from the compound nucleus reaction mechanism (Hauser-Feshbach) have been considered, we recalculate not only that contribution to the cross section but also include direct capture on even-even nuclei. The level schemes, which are of utmost importance in the direct capture calculations, are taken from quasi-particle states obtained with a folded-Yukawa potential and Lipkin-Nogami pairing. Most recent deformation values derived from experimental data on $\\beta$-decay half lives are used where available. Due to the consideration of direct capture, the capture rates are enhanced and the "turning points" in the r-process path are shifted to slightly higher mass numbers. We also discuss the sensitivity of the direct capture cross sections on the assumed deformation.

  8. Supernova Neutrino-Effects on R-Process Nucleosynthesis in Black Hole Formation

    CERN Document Server

    Sasaqui, T; Balantekin, A B

    2005-01-01

    Stars with a wide range of masses provide a variety of production sites for intermediate-to-heavy mass elements. Very massive stars with mass $\\geq 8 M_{\\odot}$ culminate their evolution by supernova explosions which are presumed to be the most viable candidate astrophysical sites of r-process nucleosynthesis. If the models for the supernova r-process are correct, then nucleosynthesis results could also pose a significant constraint on the remnant of supernova explosions, $i.e.$ neutron star or black hole. In the case of very massive core collapse, a remnant stellar black hole is thought to be formed. Intense neutrino flux from the neutronized core and the neutrino sphere might suddenly cease during the Kelvin-Helmholtz cooling phase because of the black hole formation. It is interesting to explore observable consequences of such a neutrino flux truncation. Arguments have recently been given in the literature that even the neutrino mass may be determined from the time delay of deformed neutrino energy spectru...

  9. Solar r-process-constrained actinide production in neutrino-driven winds of supernovae

    CERN Document Server

    Goriely, S

    2016-01-01

    Long-lived radioactive nuclei play an important role as nucleo-cosmochronometers and as cosmic tracers of nucleosynthetic source activity. In particular nuclei in the actinide region like thorium, uranium, and plutonium can testify to the enrichment of an environment by the still enigmatic astrophysical sources that are responsible for the production of neutron-rich nuclei by the rapid neutron-capture process (r-process). Supernovae and merging neutron-star (NS) or NS-black hole binaries are considered as most likely sources of the r-nuclei. But arguments in favour of one or the other or both are indirect and make use of assumptions; they are based on theoretical models with remaining simplifications and shortcomings. An unambiguous observational determination of a production event is still missing. In order to facilitate searches in this direction, e.g.\\ by looking for radioactive tracers in stellar envelopes, the interstellar medium or terrestrial reservoirs, we provide improved theoretical estimates and co...

  10. The Intermediate r-process in Core-collapse Supernovae Driven by the Magneto-rotational Instability

    Science.gov (United States)

    Nishimura, N.; Sawai, H.; Takiwaki, T.; Yamada, S.; Thielemann, F.-K.

    2017-02-01

    We investigated r-process nucleosynthesis in magneto-rotational supernovae, based on a new explosion mechanism induced by the magneto-rotational instability (MRI). A series of axisymmetric magneto-hydrodynamical simulations with detailed microphysics including neutrino heating is performed, numerically resolving the MRI. Neutrino-heating dominated explosions, enhanced by magnetic fields, showed mildly neutron-rich ejecta producing nuclei up to A∼ 130 (i.e., the weak r-process), while explosion models with stronger magnetic fields reproduce a solar-like r-process pattern. More commonly seen abundance patterns in our models are in between the weak and regular r-process, producing lighter and intermediate-mass nuclei. These intermediate r-processes exhibit a variety of abundance distributions, compatible with several abundance patterns in r-process-enhanced metal-poor stars. The amount of Eu ejecta ∼ {10}-5 {M}ȯ in magnetically driven jets agrees with predicted values in the chemical evolution of early galaxies. In contrast, neutrino-heating dominated explosions have a significant amount of Fe ({}56{{Ni}}) and Zn, comparable to regular supernovae and hypernovae, respectively. These results indicate magneto-rotational supernovae can produce a wide range of heavy nuclei from iron-group to r-process elements, depending on the explosion dynamics.

  11. β-decay measurements of A simeq 70 - 110 r-process nuclei at the National Superconducting Cyclotron Laboratory

    Science.gov (United States)

    Pereira, J.; Aprahamian, A.; Arndt, O.; Becerril, A.; Elliot, T.; Estrade, A.; Galaviz, D.; Hennrich, S.; Hosmer, P.; Kessler, R.; Kratz, K.-L.; Lorusso, G.; Mantica, P. F.; Matos, M.; Montes, F.; Pfeiffer, B.; Quinn, M.; Santi, P.; Schatz, H.; Schertz, F.; Schnorrenberger, L.; Smith, E.; Stolz, A.; Walters, W. B.; Wöhr, A.

    2011-09-01

    The present paper reports on several r-process motivated β-decay experiments undertaken at the National Superconducting Cyclotron Laboratory. β-decay half-lives and β-delayed neutron-emission probabilities were measured for nuclei around the r-process A = 70-80 and A = 90 - 110 mass regions. The data are discussed on the basis of quasi-random phase approximation calculations. The emphasis is made on the impact of these data upon calculations of r-process abundances.

  12. Salinity inhibits post transcriptional processing of chloroplast 16S rRNA in shoot cultures of jojoba (Simmondsia chinesis).

    Science.gov (United States)

    Mizrahi-Aviv, Ela; Mills, David; Benzioni, Aliza; Bar-Zvi, Dudy

    2005-03-01

    Chloroplast metabolism is rapidly affected by salt stress. Photosynthesis is one of the first processes known to be affected by salinity. Here, we report that salinity inhibits chloroplast post-transcriptional RNA processing. A differentially expressed 680-bp cDNA, containing the 3' sequence of 16S rRNA, transcribed intergenic spacer, exon 1 and intron of tRNA(Ile), was isolated by differential display reverse transcriptase PCR from salt-grown jojoba (Simmondsia chinesis) shoot cultures. Northern blot analysis indicated that although most rRNA appears to be fully processed, partially processed chloroplast 16S rRNA accumulates in salt-grown cultures. Thus, salinity appears to decrease the processing of the rrn transcript. The possible effect of this decreased processing on physiological processes is, as yet, unknown.

  13. Technological review of the HRP manufacturing process R and D activity

    Energy Technology Data Exchange (ETDEWEB)

    Visca, Eliseo, E-mail: eliseo.visca@enea.it [Associazione EURATOM-ENEA sulla Fusione, C.R. Frascati, Via E. Fermi 45, IT-00044 Frascati (Italy); Pizzuto, A. [Associazione EURATOM-ENEA sulla Fusione, C.R. Frascati, Via E. Fermi 45, IT-00044 Frascati (Italy); Gavila, P.; Riccardi, B. [Fusion For Energy, C. Josep Pla 2, ES-08019 Barcelona (Spain); Roccella, S. [Associazione EURATOM-ENEA sulla Fusione, C.R. Frascati, Via E. Fermi 45, IT-00044 Frascati (Italy); Candura, D.; Sanguinetti, G.P. [Ansaldo Nucleare S.p.A., Corso Perrone 25, IT-16121 Genova (Italy)

    2013-10-15

    Highlights: • R and D activities for the manufacturing of ITER divertor high heat flux plasma-facing components (HHFC). • ENEA and Ansaldo have jointly manufactured several actively cooled monoblock mock-ups and prototypical components. • Successful manufacturing by HRP (hot radial pressing) and PBC (pre-brazed casting) of both W and CFC armoured small and medium scale mockups. • ENEA-ANSALDO participate to the European programme for the qualification of the manufacturing technology for the ITER divertor IVT. • A qualification divertor inner vertical target prototype successfully tested at ITER relevant thermal heat fluxes. -- Abstract: ENEA and Ansaldo Nucleare S.p.A. have been deeply involved in the European International Thermonuclear Experimental Reactor (ITER) R and D activities for the manufacturing of high heat flux plasma-facing components (HHFC), and in particular for the inner vertical target (IVT) of the ITER divertor. This component has to be manufactured by using both armour and structural materials whose properties are defined by ITER. Their physical properties prevent the use of standard joining techniques. The reference armour materials are tungsten and carbon/carbon fibre composite (CFC). The cooling pipe is made of copper alloy (CuCrZr-IG). During the last years ENEA and Ansaldo have jointly manufactured several actively cooled monoblock mock-ups and prototypical components of different length, geometry and materials, by using innovative processes: HRP (hot radial pressing) and PBC (pre-brazed casting). The history of the technical issues solved during the R and D phase and the improvements implemented to the assembling tools and equipments are reviewed in the paper together with the testing results. The optimization of the processes started from the successful manufacturing of both W and CFC armoured small scale mockups thermal fatigue tested in the worst ITER operating condition (20 MW/m{sup 2}) through the achievement of record

  14. Process R&D under the magnifying glass: organization, business model, challenges, and scientific context.

    Science.gov (United States)

    Federsel, Hans-Jürgen

    2010-08-15

    Initially, the aim is to provide the big picture illustrating the as is situation in the pharmaceutical industry: a lack of productivity resulting in too few products reaching the market; a loss of billions in revenue over the next few years as some of the major megabrands go off patent; a spiraling cost for developing new drugs and taking them through clinical and safety studies. Following on, a look deeper into the organization will offer an insight into the state-of-the-art in a technical function accountable for chemical Process R&D (with a remit to develop scalable, robust, and cost efficient processes for small molecules). The vast majority of compounds already launched in the form of drug products on the market or still being pursued through the phases of discovery and development, fall within the category of small molecules (as opposed to biopharmaceuticals, e.g., proteins, monoclonal antibodies). This typically means molecular weights of <1000Da and puts organic synthesis in the widest sense of the word at the forefront of technologies needed to support R&D programs in the pharma industry. Understandably, the demands on Medicinal Chemistry are quite different to what applies in a Process R&D (PR&D) organization. In the former, making large numbers of potentially interesting molecules, many of which are discarded after testing, is a key driver and for this virtually any synthetic methodology will suffice. For PR&D, however, homing in on selected compounds there is an expectation that the best synthetic routes will be delivered that meet a number of tough criteria, for instance from an environmental and safety point of view, allowing operation on large scale, offering cost competitiveness, avoiding patent infringements, showing sustainability for long-term production, etc. The intention is to focus on issues to be addressed during this transition by providing examples of changes that had to be put in place in order to make the supply of larger amounts of

  15. Production of the entire range of r-process nuclides by black hole accretion disc outflows from neutron star mergers

    Science.gov (United States)

    Wu, Meng-Ru; Fernández, Rodrigo; Martínez-Pinedo, Gabriel; Metzger, Brian D.

    2016-12-01

    We consider r-process nucleosynthesis in outflows from black hole accretion discs formed in double neutron star and neutron star-black hole mergers. These outflows, powered by angular momentum transport processes and nuclear recombination, represent an important - and in some cases dominant - contribution to the total mass ejected by the merger. Here we calculate the nucleosynthesis yields from disc outflows using thermodynamic trajectories from hydrodynamic simulations, coupled to a nuclear reaction network. We find that outflows produce a robust abundance pattern around the second r-process peak (mass number A ˜ 130), independent of model parameters, with significant production of A dynamical ejecta with high electron fraction may not be required to explain the observed abundances of r-process elements in metal poor stars. Disc outflows reach the third peak (A ˜ 195) in most of our simulations, although the amounts produced depend sensitively on the disc viscosity, initial mass or entropy of the torus, and nuclear physics inputs. Some of our models produce an abundance spike at A = 132 that is absent in the Solar system r-process distribution. The spike arises from convection in the disc and depends on the treatment of nuclear heating in the simulations. We conclude that disc outflows provide an important - and perhaps dominant - contribution to the r-process yields of compact binary mergers, and hence must be included when assessing the contribution of these systems to the inventory of r-process elements in the Galaxy.

  16. The influence of neutrinos on r-process nucleosynthesis in the ejecta of black hole-neutron star mergers

    Science.gov (United States)

    Roberts, Luke F.; Lippuner, Jonas; Duez, Matthew D.; Faber, Joshua A.; Foucart, Francois; Lombardi, James C., Jr.; Ning, Sandra; Ott, Christian D.; Ponce, Marcelo

    2017-02-01

    During the merger of a black hole and a neutron star, baryonic mass can become unbound from the system. Because the ejected material is extremely neutron-rich, the r-process rapidly synthesizes heavy nuclides as the material expands and cools. In this work, we map general relativistic models of black hole-neutron star mergers into a Newtonian smoothed particle hydrodynamics (SPH) code and follow the evolution of the thermodynamics and morphology of the ejecta until the outflows become homologous. We investigate how the subsequent evolution depends on our mapping procedure and find that the results are robust. Using thermodynamic histories from the SPH particles, we then calculate the expected nucleosynthesis in these outflows while varying the level of neutrino irradiation coming from the post-merger accretion disc. We find that the ejected material robustly produces r-process nucleosynthesis even for unrealistically high neutrino luminosities, due to the rapid velocities of the outflow. None the less, we find that neutrinos can have an impact on the detailed pattern of the r-process nucleosynthesis. Electron neutrinos are captured by neutrons to produce protons while neutron capture is occurring. The produced protons rapidly form low-mass seed nuclei for the r-process. These low-mass seeds are eventually incorporated into the first r-process peak at A ˜ 78. We consider the mechanism of this process in detail and discuss if it can impact galactic chemical evolution of the first peak r-process nuclei.

  17. Approaching the r-process "waiting point" nuclei below $^{132}$Sn: quadrupole collectivity in $^{128}$Cd

    CERN Multimedia

    Reiter, P; Blazhev, A A; Nardelli, S; Voulot, D; Habs, D; Schwerdtfeger, W; Iwanicki, J S

    We propose to investigate the nucleus $^{128}$Cd neighbouring the r-process "waiting point" $^{130}$Cd. A possible explanation for the peak in the solar r-abundances at A $\\approx$ 130 is a quenching of the N = 82 shell closure for spherical nuclei below $^{132}$Sn. This explanation seems to be in agreement with recent $\\beta$-decay measurements performed at ISOLDE. In contrast to this picture, a beyond-mean-field approach would explain the anomaly in the excitation energy observed for $^{128}$Cd rather with a quite large quadrupole collectivity. Therefore, we propose to measure the reduced transition strengths B(E2) between ground state and first excited 2$^{+}$-state in $^{128}$Cd applying $\\gamma$-spectroscopy with MINIBALL after "safe" Coulomb excitation of a post-accelerated beam obtained from REX-ISOLDE. Such a measurement came into reach only because of the source developments made in 2006 for experiment IS411, in particular the use of a heated quartz transfer line. The result from the proposed measure...

  18. Dexterity with numbers: rTMS over left angular gyrus disrupts finger gnosis and number processing.

    Science.gov (United States)

    Rusconi, Elena; Walsh, Vincent; Butterworth, Brian

    2005-01-01

    Since the original description of Gerstmann's syndrome with its four cardinal symptoms, among which are finger agnosia and acalculia, the neuro-cognitive relationship between fingers and calculation has been debated. We asked our participants to perform four different tasks, two of which involved fingers and the other two involving numbers, during repetitive transcranial magnetic stimulation (rTMS) over the posterior parietal lobe of either hemisphere. In the finger tasks, they were required to transform a tactile stimulus randomly delivered on one of their fingers into a speeded key-press response either with the same or with the homologous finger on the opposite hand. In the numerical tasks, they were asked to perform a magnitude or a parity matching on pairs of single digits, in the context of arithmetically related or unrelated numerical primes. In accordance with the original anatomical hypothesis put forward by Gerstmann [Gerstmann, J. (1924). Fingeragnosie: eine umschriebene Stoerung der Orienterung am eigenen Koerper. Wiener clinische Wochenschrift, 37, 1010-12], we found that rTMS over the left angular gyrus disrupted tasks requiring access to the finger schema and number magnitude processing in the same group of participants. In addition to the numerous studies which have employed special populations such as neurological patients and children, our data confirm the presence of a relationship between numbers and body knowledge in skilled adults who no longer use their fingers for solving simple arithmetical tasks.

  19. Chemical Process R&D for Pharmaceutical Industry in the New Millennium, Challenges and Opportunities

    Institute of Scientific and Technical Information of China (English)

    ZHANG; Tony; Yantao

    2001-01-01

    The genomic revolution has offered scientists in the world with unprecedented number of targets and opportunities to eradicate human diseases. High throughput screening technology using enzymatic and receptor binding assays has shifted the bottleneck in drug discovery to the laboratories of chemistry. Recent upsurge of interest in combinatorial chemistry is a testimony to the urgency of increasing the efficiency of how drug-like molecules are made. What the implication of all these on chemical process research? If the Internet has revolutionized the distribution and of data, information, and knowledge, how can this powerful tool be utilized to harness the collective intellect of chemists all across the world? If the effort of a few thousands people was able to send men to the moon, can the cross-pollination of ideas from chemists all over the world, each of them thinking in his or her unique way, produce the most cost effective way of making a particular molecule, reduce pollution of a current process, or deliver a cure for cancer? We will examine the brief history of modern organic chemistry and provide some personal musings on different course one can take in the area of chemical process R&D.  ……

  20. Chemical Process R&D for Pharmaceutical Industry in the New Millennium, Challenges and Opportunities

    Institute of Scientific and Technical Information of China (English)

    ZHANG Tony Yantao; BINGHAM Alphus

    2001-01-01

    @@ The genomic revolution has offered scientists in the world with unprecedented number of targets and opportunities to eradicate human diseases. High throughput screening technology using enzymatic and receptor binding assays has shifted the bottleneck in drug discovery to the laboratories of chemistry. Recent upsurge of interest in combinatorial chemistry is a testimony to the urgency of increasing the efficiency of how drug-like molecules are made. What the implication of all these on chemical process research? If the Internet has revolutionized the distribution and of data, information, and knowledge, how can this powerful tool be utilized to harness the collective intellect of chemists all across the world? If the effort of a few thousands people was able to send men to the moon, can the cross-pollination of ideas from chemists all over the world, each of them thinking in his or her unique way, produce the most cost effective way of making a particular molecule, reduce pollution of a current process, or deliver a cure for cancer? We will examine the brief history of modern organic chemistry and provide some personal musings on different course one can take in the area of chemical process R&D.

  1. In search of sustainability: process R&D in light of current pharmaceutical industry challenges.

    Science.gov (United States)

    Federsel, Hans-Jürgen

    2006-11-01

    Is there a need for a paradigm shift in the pharmaceutical industry? Many researchers think so and take as examples the eroding corporate reputation, a regulatory environment that is harsher than ever, and the request for cheaper drugs from patient organizations and authorities. Process R&D, which interfaces medicinal chemistry and production, has taken on this challenge by increasing the delivery focus early on to ensure timely availability of desired compounds. The quest for lower costs of goods has forced the design of best synthetic routes that, given the molecular complexity, often lead to catalytic methodologies. Applying these methodologies will enable not only the cost element, but also the increasingly important aspects of environmental friendliness, and atom and stage efficiency, to be addressed.

  2. Constraint on the cosmic age from the solar $r$-process abundances

    CERN Document Server

    Heng, T H; Niu, Z M; Sun, B H; Guo, J Y

    2014-01-01

    The cosmic age is an important physical quantity in cosmology. Based on the radiometric method, a reliable lower limit of the cosmic age is derived to be $15.68\\pm 1.95$ Gyr by using the $r$-process abundances inferred for the solar system and observations in metal-poor stars. This value is larger than the latest cosmic age $13.813\\pm 0.058$ Gyr from Planck 2013 results, while they still agree with each other within the uncertainties. The uncertainty of $1.95$ Gyr mainly originates from the error on thorium abundance observed in metal-poor star CS 22892-052, so future high-precision abundance observations on CS 22892-052 are needed to understand this age deviation.

  3. The Role of Fission in Neutron Star Mergers and the Position of the Third r-Process Peak

    CERN Document Server

    Eichler, Marius; Kelic, Alexandra; Korobkin, Oleg; Langanke, Karlheinz; Martinez-Pinedo, Gabriel; Panov, Igor V; Rauscher, Thomas; Rosswog, Stephan; Winteler, Christian; Zinner, Nikolaj T; Thielemann, Friedrich-Karl

    2014-01-01

    The comparison between observational abundance features and those obtained from nucleosynthesis predictions of stellar evolution and/or explosion simulations can scrutinize two aspects: (a) the conditions in the astrophysical production site and (b) the quality of the nuclear physics input utilized. Here we test the abundance features of r-process nucleosynthesis calculations for the dynamical ejecta of neutron star merger simulations based on three different nuclear mass models: The Finite Range Droplet Model (FRDM), the (quenched version of the) Extended Thomas Fermi Model with Strutinsky Integral (ETFSI-Q), and the Hartee-Fock-Bogoliubov (HFB) mass model. We make use of corresponding fission barrier heights and compare the impact of four different fission fragment distribution models on the final r-process abundance distribution. Furthermore, we explore the origin of a shift in the third r-process peak position in comparison with the solar r-process abundances which have been noticed in a number of merger ...

  4. J.R. Simplot: Burner Upgrade Project Improves Performance and Saves Energy at a Large Food Processing Plant

    Energy Technology Data Exchange (ETDEWEB)

    2005-09-01

    This DOE Industrial Program case study describes how the J.R. Simplot Company saved energy and money by increasing the efficiency of the steam system in its potato processing plant in Caldwell, Idaho.

  5. J.R. Simplot: Burner Upgrade Project Improves Performance and Saves Energy at a Large Food Processing Plant (Steam)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2005-09-01

    This DOE Industrial Program case study describes how the J.R. Simplot Company saved energy and money by increasing the efficiency of the steam system in its potato processing plant in Caldwell, Idaho.

  6. J.R. Simplot: Burner Upgrade Project Improves Performance and Saves Energy at a Large Food Processing Plant

    Energy Technology Data Exchange (ETDEWEB)

    2005-09-01

    This DOE Industrial Program case study describes how the J.R. Simplot Company saved energy and money by increasing the efficiency of the steam system in its potato processing plant in Caldwell, Idaho.

  7. J.R. Simplot: Burner Upgrade Project Improves Performance and Saves Energy at a Large Food Processing Plant (Steam)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2005-09-01

    This DOE Industrial Program case study describes how the J.R. Simplot Company saved energy and money by increasing the efficiency of the steam system in its potato processing plant in Caldwell, Idaho.

  8. Reproducible Data Processing Research for the CABRI R.I.A. experiments Acoustic Emission signal analysis

    Energy Technology Data Exchange (ETDEWEB)

    Pantera, Laurent [CEA, DEN, CAD/DER/SRES/LPRE, Cadarache, F-13108 Saint-Paul-lez-Durance (France); Issiaka Traore, Oumar [Laboratory of Machanics and Acoustics (LMA) CNRS, 13402 Marseille (France)

    2015-07-01

    The CABRI facility is an experimental nuclear reactor of the French Atomic Energy Commission (CEA) designed to study the behaviour of fuel rods at high burnup under Reactivity Initiated Accident (R.I.A.) conditions such as the scenario of a control rod ejection. During the experimental phase, the behaviour of the fuel element generates acoustic waves which can be detected by two microphones placed upstream and downstream from the test device. Studies carried out on the last fourteen tests showed the interest in carrying out temporal and spectral analyses on these signals by showing the existence of signatures which can be correlated with physical phenomena. We want presently to return to this rich data in order to have a new point of view by applying modern signal processing methods. Such an antecedent works resumption leads to some difficulties. Although all the raw data are accessible in the form of text files, analyses and graphics representations were not clear in reproducing from the former studies since the people who were in charge of the original work have left the laboratory and it is not easy when time passes, even with our own work, to be able to remember the steps of data manipulations and the exact setup. Thus we decided to consolidate the availability of the data and its manipulation in order to provide a robust data processing workflow to the experimentalists before doing any further investigations. To tackle this issue of strong links between data, treatments and the generation of documents, we adopted a Reproducible Research paradigm. We shall first present the tools chosen in our laboratory to implement this workflow and, then we shall describe the global perception carried out to continue the study of the Acoustic Emission signals recorded by the two microphones during the last fourteen CABRI R.I.A. tests. (authors)

  9. The Drivers of Transnational Subsidiary Evolution: The Upgrading of Process R&D in the Irish Pharmaceutical Industry

    OpenAIRE

    Van Egeraat, Chris; Breathnach, Proinnsias

    2012-01-01

    The drivers of transnational subsidiary evolution: the upgrading of process R&D in the Irish pharmaceutical industry, Regional Studies. This paper contributes to the theory of subsidiary evolution in large corporations through an examination of the driving forces behind upgrading of process research and development (R&D) activities in the Irish pharmaceutical industry. Drawing on a survey of pharmaceutical plants and interviews with transnational pharmaceutical plants, it is shown...

  10. Impact of new data for neutron-rich heavy nuclei on theoretical models for r-process nucleosynthesis

    Science.gov (United States)

    Kajino, Toshitaka; Mathews, Grant J.

    2017-08-01

    Current models for the r process are summarized with an emphasis on the key constraints from both nuclear physics measurements and astronomical observations. In particular, we analyze the importance of nuclear physics input such as beta-decay rates; nuclear masses; neutron-capture cross sections; beta-delayed neutron emission; probability of spontaneous fission, beta- and neutron-induced fission, fission fragment mass distributions; neutrino-induced reaction cross sections, etc. We highlight the effects on models for r-process nucleosynthesis of newly measured β-decay half-lives, masses, and spectroscopy of neutron-rich nuclei near the r-process path. We overview r-process nucleosynthesis in the neutrino driven wind above the proto-neutron star in core collapse supernovae along with the possibility of magneto-hydrodynamic jets from rotating supernova explosion models. We also consider the possibility of neutron star mergers as an r-process environment. A key outcome of newly measured nuclear properties far from stability is the degree of shell quenching for neutron rich isotopes near the closed neutron shells. This leads to important constraints on the sites for r-process nucleosynthesis in which freezeout occurs on a rapid timescale.

  11. Contribution of Neutron Star Mergers to the r-Process Chemical Evolution in the Hierarchical Galaxy Formation

    Science.gov (United States)

    Komiya, Yutaka; Shigeyama, Toshikazu

    2016-10-01

    The main astronomical source of r-process elements has not yet been identified. One plausible site is neutron star mergers (NSMs), but from the perspective of the Galactic chemical evolution, it has been pointed out that NSMs cannot reproduce the observed r-process abundance distribution of metal-poor stars at [{Fe}/{{H}}]\\lt -3. Recently, Tsujimoto & Shigeyama pointed out that NSM ejecta can spread into a much larger volume than ejecta from a supernova. We re-examine the enrichment of r-process elements by NSMs considering this difference in propagation using the chemical evolution model under the hierarchical galaxy formation. The observed r-process enhanced stars around [{Fe}/{{H}}]∼ -3 are reproduced if the star formation efficiency is lower for low-mass galaxies under a realistic delay-time distribution for NSMs. We show that a significant fraction of NSM ejecta escape from its host proto-galaxy to pollute intergalactic matter and other proto-galaxies. The propagation of r-process elements over proto-galaxies changes the abundance distribution at [{Fe}/{{H}}]\\lt -3 and obtains distribution compatible with observations of the Milky Way halo stars. In particular, the pre-enrichment of intergalactic medium explains the observed scarcity of extremely metal-poor stars without Ba and abundance distribution of r-process elements at [{Fe}/{{H}}]≲ -3.5.

  12. Possible discovery of the r-process characteristics in the abundances of metal-rich barium stars

    CERN Document Server

    Cui, W Y; Shi, J R; Zhao, G; Wang, W J; Niu, P

    2014-01-01

    We study the abundance distributions of a sample of metal-rich barium stars provided by Pereira et al. (2011) to investigate the s- and r-process nucleosynthesis in the metal-rich environment. We compared the theoretical results predicted by a parametric model with the observed abundances of the metal-rich barium stars. We found that six barium stars have a significant r-process characteristic, and we divided the barium stars into two groups: the r-rich barium stars ($C_r>5.0$, [La/Nd]\\,$<0$) and normal barium stars. The behavior of the r-rich barium stars seems more like that of the metal-poor r-rich and CEMP-r/s stars. We suggest that the most possible formation mechanism for these stars is the s-process pollution, although their abundance patterns can be fitted very well when the pre-enrichment hypothesis is included. The fact that we can not explain them well using the s-process nucleosynthesis alone may be due to our incomplete knowledge on the production of Nd, Eu, and other relevant elements by the ...

  13. R-process and alpha-elements in the Galactic disk: Kinematic correlations

    CERN Document Server

    Koch, A

    2004-01-01

    Recent studies of elemental abundances in the Galactic halo and in the Galactic disk have underscored the possibility to kinematically separate different Galactic subcomponents. Correlations between the galactocentric rotation velocity and various element ratios were found, providing an important means to link different tracers of star formation and metal enrichment to the Galactic components of different origin (collapse vs. accretion). In the present work we determine stellar kinematics for a sample of 124 disk stars, which we derive from their orbits based on radial velocities and proper motions from the the literature. Our stars form a subsample of the Edvardsson et al. (1993) sample and we concentrate on three main tracers: (i) Europium as an r-process element is predominantly produced in Supernovae of type II. (ii) Likewise, alpha-elements, such as Ca, Si, Mg, are synthesised in SNe II, contrary to iron, which is being produced preferentially in SNe Ia. (iii) The s-process element Barium is a measure of...

  14. Process R&D for CIS-Based Thin-Film PV: Final Technical Report, April 2002 - April 2005

    Energy Technology Data Exchange (ETDEWEB)

    Tarrant, D. E.; Gay, R. R.

    2006-01-01

    The primary objectives of this Shell Solar Industries subcontract are to address key near-term technical R&D issues for continued CIS product improvement; continue process development for increased production capacity; develop processes capable of significantly contributing to DOE 2020 PV shipment goals; advance mid- and longer-term R&D needed by industry for future product competitiveness including improving module performance, decreasing production process costs per watt produced, and improving reliability; and perform aggressive module lifetime R&D directed at developing packages that address the DOE goal for modules that will last up to 30 years while retaining 80% of initial power. These production R&D results, production volume, efficiency, high line yield, and advances in understanding are major accomplishments. The demonstrated and maintained high production yield is a major accomplishment supporting attractive cost projections for CIS. Process R&D at successive levels of CIS production has led to the continued demonstration of the prerequisites for commitment to large-scale commercialization. Process and packaging R&D during this and previous subcontracts has demonstrated the potential for further cost and performance improvements.

  15. The integration of process R&D in drug discovery--challenges and opportunities.

    Science.gov (United States)

    Federsel, Hans-Jürgen

    2006-02-01

    In today's situation where a lot of attention is put on the whereabouts of the pharmaceutical industry, especially focusing on productivity, pricing policies, time lines, and competition, there is an increased need for a critical revision of work practices in the business. The prevailing prioritization of time-to-market is now more and more shifting over to also put quality, risk management, and effectiveness/efficiency in the limelight. Resources in terms of people and money will continue to be constrained and, therefore, best collaborative principles have to be adopted between different parts of the organization. Only by operating this way will we maximize the output. One of the most important key performance indicators in pharma R&D is the number of newly appointed candidate drugs (CDs). However, it is not only a matter of counting numbers but, more so, to nominate compounds with the best properties and likelihood to survive. In that vein the demands on Process R&D have gone up considerably over recent years and there is now a pronounced need to make forecasts on cost of goods for the API (active pharmaceutical ingredient), scalability issues, IP matters, route design etc. On top of this, there is as always an expectation that the supply of material needed to conduct the various studies is timely, fully reliable, and flexible, even if volumes and delivery dates fluctuate widely. To successfully be able to cope with this challenging and sometimes stressful situation a back-integration into earlier parts of Drug Discovery is a must and, hence, connecting to new projects will have to be initiated already during the LO-stage (lead optimization). The consequences of this and its further implications will constitute the core part of the paper.

  16. Chemo-dynamical evolution of the Local Group dwarf galaxies: The origin of r-process elements

    Science.gov (United States)

    Hirai, Y.; Ishimaru, Y.; Saitoh, T. R.; Fujii, M. S.; Hidaka, J.; Kajino, T.

    2016-06-01

    The r-process elements such as Au, Eu, and U are observed in the extremely metal-poor stars in the Milky Way halo and the Local Group dwarf galaxies. However, the origin of r-process elements has not yet been identified. The abundance of r-process elements of stars in the Local Group galaxies provides clues to clarify early evolutionary history of galaxies. It is important to understand the chemical evolution of the Local Group dwarf galaxies which would be building blocks of the Milky Way. In this study, we perform a series of N-body/smoothed particle hydrodynamic simulations of dwarf galaxies. We show that neutron star mergers can reproduce the observation of r-process elements. We find that the effects of gas mixing processes including metals in the star-forming region of a typical scale of giant molecular clouds ¥sim 10-100 pc play significant roles in the early chemical enrichment of dwarf galaxies. We also find that the star formation rate of ˜ 10^{-3} M_{⊙}yr^{-1} in early epoch (<1 Gyr) of galactic halo evolution is necessary for these results. Our results suggest that neutron star mergers are a major site of r-process.

  17. Chemo-dynamical evolution model: Enrichment of r-process elements in the Local Group dwarf galaxies

    Science.gov (United States)

    Hirai, Yutaka; Ishimaru, Yuhri; Saitoh, Takayuki R.; Fujii, Michiko S.; Hidaka, Jun; Kajino, Toshitaka

    2016-08-01

    Neutron star mergers are one of the candidate astrophysical site(s) of r-process. Several chemical evolution studies however pointed out that the observed abundance of r-process is difficult to reproduce by neutron star mergers. In this study, we aim to clarify the enrichment of r-process elements in the Local Group dwarf galaxies. We carry out numerical simulations of galactic chemo-dynamical evolution using an N-body/smoothed particle hydrodynamics code, ASURA. We construct a chemo-dynamical evolution model for dwarf galaxies assuming that neutron star mergers are the major source of r-process elements. Our models reproduce the observed dispersion in [Eu/Fe] as a function of [Fe/H] with neutron star mergers with a merger time of 100 Myr. We find that star formation efficiency and metal mixing processes during the first <~ 300 Myr of galaxy evolution are important to reproduce the observations. This study supports that neutron star mergers are a major site of r-process.

  18. COPASutils: an R package for reading, processing, and visualizing data from COPAS large-particle flow cytometers.

    Science.gov (United States)

    Shimko, Tyler C; Andersen, Erik C

    2014-01-01

    The R package COPASutils provides a logical workflow for the reading, processing, and visualization of data obtained from the Union Biometrica Complex Object Parametric Analyzer and Sorter (COPAS) or the BioSorter large-particle flow cytometers. Data obtained from these powerful experimental platforms can be unwieldy, leading to difficulties in the ability to process and visualize the data using existing tools. Researchers studying small organisms, such as Caenorhabditis elegans, Anopheles gambiae, and Danio rerio, and using these devices will benefit from this streamlined and extensible R package. COPASutils offers a powerful suite of functions for the rapid processing and analysis of large high-throughput screening data sets.

  19. COPASutils: an R package for reading, processing, and visualizing data from COPAS large-particle flow cytometers.

    Directory of Open Access Journals (Sweden)

    Tyler C Shimko

    Full Text Available The R package COPASutils provides a logical workflow for the reading, processing, and visualization of data obtained from the Union Biometrica Complex Object Parametric Analyzer and Sorter (COPAS or the BioSorter large-particle flow cytometers. Data obtained from these powerful experimental platforms can be unwieldy, leading to difficulties in the ability to process and visualize the data using existing tools. Researchers studying small organisms, such as Caenorhabditis elegans, Anopheles gambiae, and Danio rerio, and using these devices will benefit from this streamlined and extensible R package. COPASutils offers a powerful suite of functions for the rapid processing and analysis of large high-throughput screening data sets.

  20. RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway.

    Science.gov (United States)

    Lindahl, Lasse; Bommankanti, Ananth; Li, Xing; Hayden, Lauren; Jones, Adrienne; Khan, Miriam; Oni, Tolulope; Zengel, Janice M

    2009-07-01

    RNase MRP is a nucleolar RNA-protein enzyme that participates in the processing of rRNA during ribosome biogenesis. Previous experiments suggested that RNase MRP makes a nonessential cleavage in the first internal transcribed spacer. Here we report experiments with new temperature-sensitive RNase MRP mutants in Saccharomyces cerevisiae that show that the abundance of all early intermediates in the processing pathway is severely reduced upon inactivation of RNase MRP. Transcription of rRNA continues unabated as determined by RNA polymerase run-on transcription, but the precursor rRNA transcript does not accumulate, and appears to be unstable. Taken together, these observations suggest that inactivation of RNase MRP blocks cleavage at sites A0, A1, A2, and A3, which in turn, prevents precursor rRNA from entering the canonical processing pathway (35S > 20S + 27S > 18S + 25S + 5.8S rRNA). Nevertheless, at least some cleavage at the processing site in the second internal transcribed spacer takes place to form an unusual 24S intermediate, suggesting that cleavage at C2 is not blocked. Furthermore, the long form of 5.8S rRNA is made in the absence of RNase MRP activity, but only in the presence of Xrn1p (exonuclease 1), an enzyme not required for the canonical pathway. We conclude that RNase MRP is a key enzyme for initiating the canonical processing of precursor rRNA transcripts, but alternative pathway(s) might provide a backup for production of small amounts of rRNA.

  1. Production of all $r$-process nuclides by black hole accretion disk outflows from neutron star mergers

    CERN Document Server

    Wu, Meng-Ru; Martínez-Pinedo, Gabriel; Metzger, Brian D

    2016-01-01

    We consider $r$-process nucleosynthesis in outflows from black hole accretion disks formed in double neutron star and neutron star - black hole mergers. These outflows, powered by angular momentum transport processes and nuclear recombination, represent an important -- and in some cases dominant -- contribution to the total mass ejected by the merger. Here we calculate the nucleosynthesis yields from disk outflows using thermodynamic trajectories from hydrodynamic simulations, coupled to a nuclear reaction network. We find that outflows produce a robust abundance pattern around the second $r$-process peak (mass number $A \\sim 130$), independent of model parameters, with significant production of $A < 130$ nuclei. This implies that dynamical ejecta with high electron fraction may not be required to explain the observed abundances of $r$-process elements in metal poor stars. Disk outflows reach the third peak ($ A \\sim 195$) in most of our simulations, although the amounts produced depend sensitively on the ...

  2. Impact of weak interactions of free nucleons on the r-process in dynamical ejecta from neutron star mergers

    Science.gov (United States)

    Goriely, S.; Bauswein, A.; Just, O.; Pllumbi, E.; Janka, H.-Th.

    2015-10-01

    We investigate β-interactions of free nucleons and their impact on the electron fraction (Ye) and r-process nucleosynthesis in ejecta characteristic of binary neutron star mergers (BNSMs). For that we employ trajectories from a relativistic BNSM model to represent the density-temperature evolutions in our parametric study. In the high-density environment, positron captures decrease the neutron richness at the high temperatures predicted by the hydrodynamic simulation. Circumventing the complexities of modelling three-dimensional neutrino transport, (anti)neutrino captures are parametrized in terms of prescribed neutrino luminosities and mean energies, guided by published results and assumed as constant in time. Depending sensitively on the adopted νe-bar{ν }_e luminosity ratio, neutrino processes increase Ye to values between 0.25 and 0.40, still allowing for a successful r-process compatible with the observed solar abundance distribution and a significant fraction of the ejecta consisting of r-process nuclei. If the νe luminosities and mean energies are relatively large compared to the bar{ν }_e properties, the mean Ye might reach values >0.40 so that neutrino captures seriously compromise the success of the r-process. In this case, the r-abundances remain compatible with the solar distribution, but the total amount of ejected r-material is reduced to a few per cent, because the production of iron-peak elements is favoured. Proper neutrino physics, in particular also neutrino absorption, have to be included in BNSM simulations before final conclusions can be drawn concerning r-processing in this environment and concerning observational consequences like kilonovae, whose peak brightness and colour temperature are sensitive to the composition-dependent opacity of the ejecta.

  3. Advanced LIGO Constraints on Neutron Star Mergers and R-Process Sites

    CERN Document Server

    Côté, Benoit; Fryer, Chris L; Ritter, Christian; Paul, Adam; Wehmeyer, Benjamin; O'Shea, Brian W

    2016-01-01

    The role of compact binary mergers as the main production site of r-process elements is investigated by combining stellar abundances of Eu observed in the Milky Way, galactic chemical evolution (GCE) simulations, binary population synthesis models, and Advanced LIGO gravitational wave measurements. We compiled and reviewed seven recent GCE studies to extract the frequency of neutron star - neutron star (NS-NS) mergers that is needed in order to reproduce the observed [Eu/Fe] vs [Fe/H] relationship. We used our simple chemical evolution code to explore the impact of different analytical delay-time distribution (DTD) functions for NS-NS mergers. We then combined our metallicity-dependent population synthesis models with our chemical evolution code to bring their predictions, for both NS-NS mergers and black hole - neutron star mergers, into a GCE context. Finally, we convolved our results with the cosmic star formation history to provide a direct comparison with current and upcoming Advanced LIGO measurements. ...

  4. Export Control Requirements for Tritium Processing Design and R&D

    Energy Technology Data Exchange (ETDEWEB)

    Hollis, William Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Maynard, Sarah-Jane Wadsworth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-10-30

    This document will address requirements of export control associated with tritium plant design and processes. Los Alamos National Laboratory has been working in the area of tritium plant system design and research and development (R&D) since the early 1970’s at the Tritium Systems Test Assembly (TSTA). This work has continued to the current date with projects associated with the ITER project and other Office of Science Fusion Energy Science (OS-FES) funded programs. ITER is currently the highest funding area for the DOE OS-FES. Although export control issues have been integrated into these projects in the past a general guidance document has not been available for reference in this area. To address concerns with currently funded tritium plant programs and assist future projects for FES, this document will identify the key reference documents and specific sections within related to tritium research. Guidance as to the application of these sections will be discussed with specific detail to publications and work with foreign nationals.

  5. Export Control Requirements for Tritium Processing Design and R&D

    Energy Technology Data Exchange (ETDEWEB)

    Hollis, William Kirk [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Maynard, Sarah-Jane Wadsworth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-04-05

    This document will address requirements of export control associated with tritium plant design and processes. Los Alamos National Laboratory has been working in the area of tritium plant system design and research and development (R&D) since the early 1970’s at the Tritium Systems Test Assembly (TSTA). This work has continued to the current date with projects associated with the ITER project and other Office of Science Fusion Energy Science (OS-FES) funded programs. ITER is currently the highest funding area for the DOE OS-FES. Although export control issues have been integrated into these projects in the past a general guidance document has not been available for reference in this area. To address concerns with currently funded tritium plant programs and assist future projects for FES, this document will identify the key reference documents and specific sections within related to tritium research. Guidance as to the application of these sections will be discussed with specific detail to publications and work with foreign nationals.

  6. The Hamburg/ESO R-process Enhanced Star survey (HERES) IV. Detailed abundance analysis and age dating of the strongly r-process enhanced stars CS 29491-069 and HE 1219-0312

    CERN Document Server

    Hayek, W; Christlieb, N; Eriksson, K; Korn, A J; Barklem, P S; Hill, V; Beers, T C; Farouqi, K; Pfeiffer, B; Kratz, K -L

    2009-01-01

    We report on a detailed abundance analysis of two strongly r-process enhanced, very metal-poor stars newly discovered in the HERES project, CS 29491-069 ([Fe/H]=-2.51, [r/Fe]=+1.1) and HE 1219-0312 ([Fe/H]=-2.96, [r/Fe]=+1.5). The analysis is based on high-quality VLT/UVES spectra and MARCS model atmospheres. We detect lines of 15 heavy elements in the spectrum of CS 29491-069, and 18 in HE 1219-0312; in both cases including the Th II 4019 {\\AA} line. The heavy-element abundance patterns of these two stars are mostly well-matched to scaled solar residual abundances not formed by the s-process. We also compare the observed pattern with recent high-entropy wind (HEW) calculations, which assume core-collapse supernovae of massive stars as the astrophysical environment for the r-process, and find good agreement for most lanthanides. The abundance ratios of the lighter elements strontium, yttrium, and zirconium, which are presumably not formed by the main r-process, are reproduced well by the model. Radioactive da...

  7. A Stringent Limit on the Mass Production Rate of $r$-Process Elements in the Milky Way

    CERN Document Server

    Macias, Phillip

    2016-01-01

    We analyze data from several studies of metal-poor stars in the Milky Way, focusing on both strong (Eu) and weak (Sr) $r$-process elements. Because these elements were injected in an explosion, we calculate the mass swept up when the blast wave first becomes radiative, yielding a lower limit for the dilution of such elements and hence a lower limit on the ejecta mass which is incorporated into the next generation of stars. Our study demonstrates that in order to explain the largest enhancements in [Eu/Fe] observed in stars at low [Fe/H] metallicities, individual $r$-process production events must synthesize a minimum of $10^{-3.5} M_{\\odot}$ of $r$-process material. We also show that if the site of Mg production is the same as that of Eu, individual injection events must synthesize up to $ \\sim 10^{-3} M_{\\odot}$ of $r$-process material. On the other hand, demanding that Sr traces Mg production results in $r$-process masses per event of $\\sim 10^{-5} M_{\\odot}$. This suggests that the astrophysical sites resp...

  8. Contribution of Neutron Star Mergers to the R-process Chemical Evolution in the Hierarchical Galaxy Formation

    CERN Document Server

    Komiya, Yutaka

    2016-01-01

    The main astronomical source of r-process elements has not yet been identified. One plausible site is neutron star mergers (NSMs), but from perspective of the Galactic chemical evolution, it has been pointed out that NSMs cannot reproduce the observed r-process abundance distribution of metal-poor stars at [Fe/H] $< -3$. Recently, Tsujimoto & Shigeyama (2014) pointed out that NSM ejecta can spread into much larger volume than ejecta from a supernova. We re-examine the enrichment of r-process elements by NSMs considering this difference in propagation using the chemical evolution model under the hierarchical galaxy formation. The observed r-process enhanced stars around [Fe/H] $\\sim -3$ are reproduced if the star formation efficiency is lower for low-mass galaxies under a realistic delay time distribution for NSMs. We show that a significant fraction of NSM ejecta escape from its host proto-galaxy to pollute intergalactic matter and other proto-galaxies. The propagation of r-process elements over proto-...

  9. Impact of new data for neutron-rich heavy nuclei on theoretical models for $r$-process nucleosynthesis

    CERN Document Server

    Kajino, Toshitaka

    2016-01-01

    Current models for the $r$ process are summarized with an emphasis on the key constraints from both nuclear physics measurements and astronomical observations. In particular, we analyze the importance of nuclear physics input such as beta-decay rates; nuclear masses; neutron-capture cross sections; beta-delayed neutron emission; probability of spontaneous fission, beta- and neutron-induced fission, fission fragment mass distributions; neutrino-induced reaction cross sections, etc. We highlight the effects on models for $r$-process nucleosynthesis of newly measured $\\beta$-decay half-lives, masses, and spectroscopy of neutron-rich nuclei near the $r$-process path. We overview r-process nucleosynthesis in the neutrino driven wind above the proto-neutron star in core collapse supernovae along with the possibility of magneto-hydrodynamic jets from rotating supernova explosion models. We also consider the possibility of neutron star mergers as an r-process environment. A key outcome of newly measured nuclear prope...

  10. Has asialoglycoprotein receptor (ASGP-R) a role to play in binding and processing of different parasites?

    OpenAIRE

    2002-01-01

    Liver asialoglycoprotein receptor (ASGP-R), which specifically recognizes and binds galactose and N-acetyl galactosamine, has been implicated in binding and endocytosis of glycoproteins. Therefore, the possibility that it may have a role in contacting and processing pathogenic organisms was investigated. The interaction in vitro between ASGP-R and surface oligosaccharide structures of Echinococcus granulosus and Trichinella spiralis was studied by immunohistochemical methods. Specific binding...

  11. Impact of weak interactions of free nucleons on the r-process in dynamical ejecta from neutron-star mergers

    CERN Document Server

    Goriely, Stephane; Just, Oliver; Pllumbi, Else; Janka, Hans-Thomas

    2015-01-01

    We investigate beta-interactions of free nucleons and their impact on the electron fraction (Y_e) and r-process nucleosynthesis in ejecta characteristic of binary neutron star mergers (BNSMs). For that we employ trajectories from a relativistic BNSM model to represent the density-temperature evolutions in our parametric study. In the high-density environment, positron captures decrease the neutron richness at the high temperatures predicted by the hydrodynamic simulation. Circumventing the complexities of modelling three-dimensional neutrino transport, (anti)neutrino captures are parameterized in terms of prescribed neutrino luminosities and mean energies, guided by published results and assumed as constant in time. Depending sensitively on the adopted neutrino-antineutrino luminosity ratio, neutrino processes increase Y_e to values between 0.25 and 0.40, still allowing for a successful r-process compatible with the observed solar abundance distribution and a significant fraction of the ejecta consisting of r...

  12. The Role of Fission in Neutron Star Mergers and its Impact on the r-Process Peaks

    DEFF Research Database (Denmark)

    Eichler, Marius; Arcones, Almudena; Kelic, Alexandra

    2015-01-01

    Comparing observational abundance features with nucleosynthesis predictions of stellar evolution or explosion simulations can scrutinize two aspects: (a) the conditions in the astrophysical production site and (b) the quality of the nuclear physics input utilized. We test the abundance features...... of r-process nucleosynthesis calculations for the dynamical ejecta of neutron star merger simulations based on three different nuclear mass models: The Finite Range Droplet Model (FRDM), the (quenched version of the) Extended Thomas Fermi Model with Strutinsky Integral (ETFSI-Q), and the Hartree......-Fock-Bogoliubov (HFB) mass model. We make use of corresponding fission barrier heights and compare the impact of four different fission fragment distribution models on the final r-process abundance distribution. In particular, we explore the abundance distribution in the second r-process peak and the rare-earth sub...

  13. Analysis of Municipal Sewage Treatment Engineering by CWSBR(R) Process%CWSBR(R)工艺处理市政污水的工程分析

    Institute of Scientific and Technical Information of China (English)

    孙巍; 陈向明; 杨威; 詹技灵

    2012-01-01

    CWSBR(R) process is adopted in Wudalianchi WWTP, and it is a constant water-lever SBR with continuous influent and effluent in single pond, and a constant water-lever decanter with slight disturbance of sludge layer. After more than 2 months of sludge cultivation and the system commissioning, the step-feed in single pond is used to reinforce the nitrogen and phosphorus removal efficiency. The effluent COD, NH4+ - N and TP are less than 50 mg/L, 3 mg/L and 0.5 mg/L respectively. The effluent quality meets the first level B criteria specified in the Discharge Standard of Pollutants for Municipal Wastewater Treatment Plant (GB 18918 -2002). The operation results confirm the nitrogen and phosphorus removal ability of CWSBR(R) process.%五大连池市污水处理厂采用CWSBR(R)工艺,其特点是单池连续进、出水且水位恒定,同时采用对泥层扰动小的恒水位滗水器.经过两个多月的污泥培养与系统调试,采用单池多步进水方式,强化了系统脱氮除磷性能,调试稳定后出水COD< 50 mg/L、NH4 -N<3 mg/L、TP <0.5mg/L,出水水质满足《城镇污水处理厂污染物排放标准》(GB 18918-2002)的一级B标准.运行结果印证了CWSBR(R)工艺具有稳定的脱氮除磷功能.

  14. New Rare Earth Element Abundance Distributions for the Sun and Five r-Process-Rich Very Metal-Poor Stars

    CERN Document Server

    Sneden, Christopher; Cowan, John J; Ivans, Inese I; Hartog, Elizabeth A Den

    2009-01-01

    We have derived new abundances of the rare-earth elements Pr, Dy, Tm, Yb, and Lu for the solar photosphere and for five very metal-poor, neutron-capture r-process-rich giant stars. The photospheric values for all five elements are in good agreement with meteoritic abundances. For the low metallicity sample, these abundances have been combined with new Ce abundances from a companion paper, and reconsideration of a few other elements in individual stars, to produce internally-consistent Ba, rare-earth, and Hf (56<= Z <= 72) element distributions. These have been used in a critical comparison between stellar and solar r-process abundance mixes.

  15. Open and Closed R&D Processes: Internal Versus External Knowledge

    Directory of Open Access Journals (Sweden)

    Mohammed Saleh Al.Ansari

    2013-02-01

    Full Text Available In an attempt to help keep up with the ever changing business environments, firms arecontinuously attempting to find ways to open up their organizations boundaries, enablingexternal sources to be used. Through a means of restructuring their R&D systems, firmswill face challenges when it comes to balancing their external and internal R&D activities,allowing them to profit from the amount of external knowledge that they retrieve.Throughout this paper, discussions on the influences that R&D configuration has on theperformance of firms and moderating R&D capacity will be discussed further.According to researched findings, firms that continue to rely on external R&D actionsexperience an increase in innovative performance, up to a certain point. Larger shares ofexternal R&D services will reduce a firm’s performance. Finding the perfect mediumground is something that all chemical engineering firms will need to work on, in order toincrease innovative performance, but not ruin their performance in the same respects. Thispaper will provide an increased amount of understanding in regards to the open innovationparadigm, which suggests that opportunity costs open for R&D borders is a lot higher forfirms that possess high quality technologically based knowledge stock (Elsevier B.V., 2012.

  16. The membrane-biofilm reactor (MBfR) as a counter-diffusional biofilm process.

    Science.gov (United States)

    Nerenberg, Robert

    2016-04-01

    The membrane-biofilm reactor (MBfR), sometimes known as the membrane-aerated biofilm reactor (MABR), is an emerging treatment technology based on gas-transferring membranes. The membranes typically supply a gaseous electron donor or acceptor substrate, such as oxygen, hydrogen, and methane. The substrate diffuses through the membrane to a biofilm naturally forming on the membrane outer surface. The complementary substrate (electron donor or acceptor) typically diffuses from the bulk liquid into the biofilm, making MBfR counter diffusional. This paper reviews the unique behavior of counter-diffusional biofilms and highlights recent research on the MBfR. Key advances include insights into the microbial community structure of MBfRs, applying the MBfR to novel contaminants, providing a better understanding of biofilm morphology and its effects on MBfR behavior, and the development of methane-based MBfR applications. These advances are likely to further the development of the MBfR for environmental applications, such as energy-efficient wastewater treatment and advanced water treatment. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Managing Communication in New Product Development Process: Virtual R&D Teams and Information Technology

    OpenAIRE

    Ebrahim, Nader Ale; Ahmed, Shamsuddin; Abdul Rashid, Salwa Hanim; Taha, Zahari

    2011-01-01

    Literature proves the importance of the role of information technology in increasing the effectiveness of virtual R&D teams’ communication for new product development. However, the factors that make information technology construct in a virtual R&D team are still ambiguous. Managers of virtual R&D teams for new product development do not know “which type of technology should be used”. To address the gap and answer the question, the paper presents a set of factors that make a const...

  18. Galactic r-process enrichment by neutron star mergers in cosmological simulations of a Milky Way-mass galaxy

    CERN Document Server

    van de Voort, Freeke; Hopkins, Philip F; Keres, Dusan; Faucher-Giguere, Claude-Andre

    2014-01-01

    We quantify the stellar abundances of neutron-rich r-process nuclei in cosmological zoom-in simulations of a Milky Way-mass galaxy from the Feedback In Realistic Environments project. The galaxy is enriched with r-process elements by binary neutron star (NS) mergers and with iron and other metals by supernovae. These calculations include key hydrodynamic mixing processes not present in standard semi-analytic chemical evolution models, such as galactic winds and hydrodynamic flows associated with structure formation. We explore a range of models for the rate and delay time of NS mergers, intended to roughly bracket the wide range of models consistent with current observational constraints. We show that NS mergers can produce [r-process/Fe] abundance ratios and scatter that appear reasonably consistent with observational constraints. At low metallicity, [Fe/H]<-2, we predict there is a wide range of stellar r-process abundance ratios, with both supersolar and subsolar abundances. Low-metallicity stars or sta...

  19. An Effective Eigenchannel R-Matrix Method for Calculating Electron-Ion Scattering Processes with Spectroscopic Precision

    Institute of Scientific and Technical Information of China (English)

    GAO Xiang; LI Jia-Ming

    2012-01-01

    The electron-ion scattering processes are very important in various scientific research fields such as astrophysical studies and inertial confinement fusion research. We report our recent development of an efficient method for providing such atomic data with spectroscopic precision.Based on the Breit-Pauli and the Dirac R-matrix theory,we develop two eigenchannel R-matrix codes,referred to as R-eigen (non-relelativistic eigenchannel R-matrix)and R-R-eigen (relativistic eigenchannel R-matrix),to directly calculate the physical quantities in multichannel quantum defect theory in the whole energy regions.From such physical quantities,we can obtain all energy levels and the related scattering cross sections with accuracies comparable with spectroscopic precision.The e+Kr+ system is used as an illustration example,the degrees of accuracies of scattering matrices are calculated within about 2%,which should be much more accurate than state-of-the-art scattering experiments.

  20. Inhibition of Escherichia coli precursor-16S rRNA processing by mouse intestinal contents

    DEFF Research Database (Denmark)

    Licht, Tine Rask; Tolker-Nielsen, Tim; Holmstrøm, Kim;

    1999-01-01

    . We have applied fluorescence in situ hybridization of pre-16S rRNA to Escherichia coli cells growing in vitro in extracts from two different compartments of the mouse intestine: the caecal mucus layer, where E. coli grew rapidly, and the contents of the caecum, which supported much slower bacterial......The correlation between ribosome content and growth rate found in many bacterial species has proved useful for estimating the growth activity of individual cells by quantitative in situ rRNA hybridization. However, in dynamic environments, the stability of mature ribosomal RNA causes problems...... growth. The amounts of 23S rRNA and pre-16S rRNA measured for E. coli growing in intestinal mucus corresponded to that expected for bacteria with the observed growth rate. In contrast, the slow-growing E. coli cells present in intestinal contents turned out to have an approximately ninefold higher...

  1. Net-centric ACT-R-Based Cognitive Architecture with DEVS Unified Process

    Science.gov (United States)

    2011-04-01

    is distributed as an integrated piece of software that runs in Common Lisp . The end user is required to program in Lisp and consequently, must...ACT-R DEVS/ACT-R 1 Modular Yes Yes 2. Component-based Yes, but in Common Lisp only. Yes. Platform independent 3. Language independent No. Only...works with Lisp . Yes. Model is platform independent and can be DSL semantically anchored in DEVSML or DEVS. 4. Simulator efficiency Very limited. The

  2. The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing.

    Directory of Open Access Journals (Sweden)

    Luis G Morello

    Full Text Available NIP7 is one of the many trans-acting factors required for eukaryotic ribosome biogenesis, which interacts with nascent pre-ribosomal particles and dissociates as they complete maturation and are exported to the cytoplasm. By using conditional knockdown, we have shown previously that yeast Nip7p is required primarily for 60S subunit synthesis while human NIP7 is involved in the biogenesis of 40S subunit. This raised the possibility that human NIP7 interacts with a different set of proteins as compared to the yeast protein. By using the yeast two-hybrid system we identified FTSJ3, a putative ortholog of yeast Spb1p, as a human NIP7-interacting protein. A functional association between NIP7 and FTSJ3 is further supported by colocalization and coimmunoprecipitation analyses. Conditional knockdown revealed that depletion of FTSJ3 affects cell proliferation and causes pre-rRNA processing defects. The major pre-rRNA processing defect involves accumulation of the 34S pre-rRNA encompassing from site A' to site 2b. Accumulation of this pre-rRNA indicates that processing of sites A0, 1 and 2 are slower in cells depleted of FTSJ3 and implicates FTSJ3 in the pathway leading to 18S rRNA maturation as observed previously for NIP7. The results presented in this work indicate a close functional interaction between NIP7 and FTSJ3 during pre-rRNA processing and show that FTSJ3 participates in ribosome synthesis in human cells.

  3. Functional anatomy of top-down visuospatial processing in the human brain : evidence from rTMS

    NARCIS (Netherlands)

    Aleman, A; Schutter, DJLG; Ramsey, NF; van Honk, J; Kessels, RPC; Hoogduin, JM; Postma, A; Kahn, RS; de Haan, EHF

    2002-01-01

    The hypothesis was tested that visuospatial mental imagery relies on processing in the posterior parietal lobe. Using repetitive transcranial magnetic stimulation (rTMS) in a cross-over, sham-controlled design, we compared involvement of right posterior parietal cortex with primary visual cortex. Su

  4. The role of fission on neutron star mergers and its impact on the r-process peaks

    Science.gov (United States)

    Eichler, M.; Arcones, A.; Kelic, A.; Korobkin, O.; Langanke, K.; Marketin, T.; Martinez-Pinedo, G.; Panov, I.; Rauscher, T.; Rosswog, S.; Winteler, C.; Zinner, N. T.; Thielemann, F.-K.

    2016-06-01

    The comparison between observational abundance features and those obtained from nucleosynthesis predictions of stellar evolution and/or explosion simulations can scrutinize two aspects: (a) the conditions in the astrophysical production site and (b) the quality of the nuclear physics input utilized. Here we test the abundance features of r-process nucleosynthesis calculations using four different fission fragment distribution models. Furthermore, we explore the origin of a shift in the third r-process peak position in comparison with the solar r-process abundances which has been noticed in a number of merger nucleosynthesis predictions. We show that this shift occurs during the r-process freeze-out when neutron captures and β-decays compete and an (n,γ)-(γ,n) equilibrium is not maintained anymore. During this phase neutrons originate mainly from fission of material above A = 240. We also investigate the role of β-decay half-lives from recent theoretical advances, which lead either to a smaller amount of fissioning nuclei during freeze-out or a faster (and thus earlier) release of fission neutrons, which can (partially) prevent this shift and has an impact on the second and rare-earth peak as well.

  5. On the robustness of the r-process in neutron-star mergers against variations of nuclear masses

    Science.gov (United States)

    Mendoza-Temis, J. J.; Wu, M. R.; Martínez-Pinedo, G.; Langanke, K.; Bauswein, A.; Janka, H.-T.; Frank, A.

    2016-07-01

    r-process calculations have been performed for matter ejected dynamically in neutron star mergers (NSM), such calculations are based on a complete set of trajectories from a three-dimensional relativistic smoothed particle hydrodynamic (SPH) simulation. Our calculations consider an extended nuclear reaction network, including spontaneous, β- and neutron-induced fission and adopting fission yield distributions from the ABLA code. In this contribution we have studied the sensitivity of the r-process abundances to nuclear masses by using diferent mass models for the calculation of neutron capture cross sections via the statistical model. Most of the trajectories, corresponding to 90% of the ejected mass, follow a relatively slow expansion allowing for all neutrons to be captured. The resulting abundances are very similar to each other and reproduce the general features of the observed r-process abundance (the second and third peaks, the rare-earth peak and the lead peak) for all mass models as they are mainly determined by the fission yields. We find distinct differences in the predictions of the mass models at and just above the third peak, which can be traced back to different predictions of neutron separation energies for r-process nuclei around neutron number N = 130.

  6. Functional anatomy of top-down visuospatial processing in the human brain: evidence from rTMS

    NARCIS (Netherlands)

    Aleman, A.; Schutter, D.J.L.G.; Ramsey, N.F.; Honk, E.J. van; Kessels, R.P.C.; Hoogduin, J.M.; Postma, A.; Kahn, R.S.; Haan, E.H.F. de

    2002-01-01

    The hypothesis was tested that visuospatial mental imagery relies on processing in the posterior parietal lobe. Using repetitive transcranial magnetic stimulation (rTMS) in a cross-over, sham-controlled design, we compared involvement of right posterior parietal cortex with primary visual cortex.

  7. Functional anatomy of top-down visuospatial processing in the human brain : evidence from rTMS

    NARCIS (Netherlands)

    Aleman, A; Schutter, DJLG; Ramsey, NF; van Honk, J; Kessels, RPC; Hoogduin, JM; Postma, A; Kahn, RS; de Haan, EHF

    The hypothesis was tested that visuospatial mental imagery relies on processing in the posterior parietal lobe. Using repetitive transcranial magnetic stimulation (rTMS) in a cross-over, sham-controlled design, we compared involvement of right posterior parietal cortex with primary visual cortex.

  8. THE ROLE OF FISSION IN NEUTRON STAR MERGERS AND ITS IMPACT ON THE r-PROCESS PEAKS

    Energy Technology Data Exchange (ETDEWEB)

    Eichler, M.; Panov, I.; Rauscher, T.; Thielemann, F.-K. [Department of Physics, University of Basel, Klingelbergstrasse 82, 4056 Basel (Switzerland); Arcones, A.; Langanke, K.; Martinez-Pinedo, G. [Institut für Kernphysik, Technische Universität Darmstadt, Schlossgartenstrasse 2, D-64289 Darmstadt (Germany); Kelic, A. [GSI Helmholtzzentrum für Schwerionenforschung GmbH, Planckstrasse 1, D-64291 Darmstadt (Germany); Korobkin, O.; Rosswog, S. [The Oskar Klein Centre, Department of Astronomy, AlbaNova, Stockholm University, SE-106 91 Stockholm (Sweden); Marketin, T. [Department of Physics, Faculty of Science, University of Zagreb, 10000 Zagreb (Croatia); Winteler, C. [Institut Energie am Bau, Fachhochschule Nordwestschweiz, St. Jakobs-Strasse 84, 4132 Muttenz (Switzerland); Zinner, N. T., E-mail: marius.eichler@unibas.ch [Department of Physics and Astronomy, Aarhus University, Ny Munkegade, bygn. 1520, DK-8000 Aarhus C (Denmark)

    2015-07-20

    Comparing observational abundance features with nucleosynthesis predictions of stellar evolution or explosion simulations, we can scrutinize two aspects: (a) the conditions in the astrophysical production site and (b) the quality of the nuclear physics input utilized. We test the abundance features of r-process nucleosynthesis calculations for the dynamical ejecta of neutron star merger simulations based on three different nuclear mass models: The Finite Range Droplet Model, the (quenched version of the) Extended Thomas Fermi Model with Strutinsky Integral, and the Hartree–Fock–Bogoliubov mass model. We make use of corresponding fission barrier heights and compare the impact of four different fission fragment distribution models on the final r-process abundance distribution. In particular, we explore the abundance distribution in the second r-process peak and the rare-earth sub-peak as a function of mass models and fission fragment distributions, as well as the origin of a shift in the third r-process peak position. The latter has been noticed in a number of merger nucleosynthesis predictions. We show that the shift occurs during the r-process freeze-out when neutron captures and β-decays compete and an (n,γ)–(γ,n) equilibrium is no longer maintained. During this phase neutrons originate mainly from fission of material above A = 240. We also investigate the role of β-decay half-lives from recent theoretical advances, which lead either to a smaller amount of fissioning nuclei during freeze-out or a faster (and thus earlier) release of fission neutrons, which can (partially) prevent this shift and has an impact on the second and rare-earth peak as well.

  9. COMPACT STELLAR BINARY ASSEMBLY IN THE FIRST NUCLEAR STAR CLUSTERS AND r-PROCESS SYNTHESIS IN THE EARLY UNIVERSE

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez-Ruiz, Enrico; MacLeod, Morgan [Department of Astronomy and Astrophysics, University of California, Santa Cruz, CA 95064 (United States); Trenti, Michele [Kavli Institute for Cosmology and Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA (United Kingdom); Roberts, Luke F. [TAPIR, California Institute of Technology, Pasadena, California 91125 (United States); Lee, William H.; Saladino-Rosas, Martha I. [Instituto de Astronomía, Universidad Nacional Autónoma de México, México DF 04510, México (Mexico)

    2015-04-01

    Investigations of elemental abundances in the ancient and most metal deficient stars are extremely important because they serve as tests of variable nucleosynthesis pathways and can provide critical inferences of the type of stars that lived and died before them. The presence of r-process elements in a handful of carbon-enhanced metal-poor (CEMP-r) stars, which are assumed to be closely connected to the chemical yield from the first stars, is hard to reconcile with standard neutron star mergers. Here we show that the production rate of dynamically assembled compact binaries in high-z nuclear star clusters can attain a sufficient high value to be a potential viable source of heavy r-process material in CEMP-r stars. The predicted frequency of such events in the early Galaxy, much lower than the frequency of Type II supernovae but with significantly higher mass ejected per event, can naturally lead to a high level of scatter of Eu as observed in CEMP-r stars.

  10. Rolling Deck to Repository (R2R): Programmatic Quality Assessment and Processing of Marine Gravity and Magnetic Data and Associated Metadata

    Science.gov (United States)

    Morton, J. J.; Ferrini, V.; O'hara, S. H.; Arko, R. A.; Carbotte, S. M.; Coakley, B.

    2011-12-01

    With its global capability and diverse array of sensors, the U.S. academic research fleet is an integral component of ocean exploration. The Rolling Deck to Repository (R2R) Program provides a central shore-side gateway for underway data from the U.S. academic research fleet, with the primary goal of preserving and documenting routine underway data. Programmatic tools for Quality Assessment (QA) of multiple underway data types are being developed to provide prompt feedback to shipboard operators and inform down-stream science users. QA tools are being developed in object oriented PHP with modular components that can be distributed for use by the community. Programmatic data processing (DP) tools for select data types are also being developed. We report on recent progress with QA and DP tools developed for underway gravity and magnetics data. For magnetics data, DP includes despiking and removal of bad data, merging with navigation, turn removal, calculation of a layback position, and removal of the IGRF to produce a magnetic anomaly. For gravity data, DP involves merging with navigation, corrections for speed and heading (Eötvös) and latitude, some basic filtering, removing bad data, subsampling, and drift corrections. All of these tools follow a programmatic workflow that requires minimal human intervention. Advanced processing which requires human intervention is left to the science user. These tools make use of metadata specific to each device and data type, as well as customizable thresholds and processing parameters. The full suite of metadata that describes each data set, the quality assessment parameters and results, as well as processing steps will accompany the data being submitted to the National Geophysical Data Center. In addition to QA reports for raw data files, day plots are also produced at each step to allow for quick observation and verification of the data quality and processing steps. These plots will also be delivered with the data files. The

  11. NMDA-R inhibition affects cellular process formation in Tilapia melanocytes; a model for pigmented adrenergic neurons in process formation and retraction.

    Science.gov (United States)

    Ogundele, Olalekan Michael; Okunnuga, Adetokunbo Adedotun; Fabiyi, Temitope Deborah; Olajide, Olayemi Joseph; Akinrinade, Ibukun Dorcas; Adeniyi, Philip Adeyemi; Ojo, Abiodun Ayodele

    2014-06-01

    Parkinson's disease has long been described to be a product of dopamine and (or) melanin loss in the substanstia nigra (SN). Although most studies have focused on dopaminergic neurons, it is important to consider the role of pigment cells in the etiology of the disease and to create an in vitro live cell model for studies involving pigmented adrenergic cells of the SN in Parkinsonism. The Melanocytes share specific features with the pigmented adrenergic neurons as both cells are pigmented, contain adrenergic receptors and have cellular processes. Although the melanocyte cellular processes are relatively short and observable only when stimulated appropriately by epinephrine and other factors or molecules. This study employs the manipulation of N-Methyl-D-Aspartate Receptor (NMDA-R), a major receptor in neuronal development, in the process formation pattern of the melanocyte in order to create a suitable model to depict cellular process elongation and shortening in pigmented adrenergic cells. NMDA-R is an important glutamate receptor implicated in neurogenesis, neuronal migration, maturation and cell death, thus we investigated the role of NMDA-R potentiation by glutamate/KCN and its inhibition by ketamine in the behavior of fish scale melanocytes in vitro. This is aimed at establishing the regulatory role of NMDA-R in this cell type (melanocytes isolated form Tilapia) in a similar manner to what is observable in the mammalian neurons. In vitro live cell culture was prepared in modified Ringer's solution following which the cells were treated as follows; Control, Glutamate, Ketamine, Glutamate + Ketamine, KCN + Ketamine and KCN. The culture was maintained for 10 min and the changes were captured in 3D-Time frame at 0, 5 and 10 min for the control and 5, 7 and 10 min for each of the treatment category. Glutamate treatment caused formation of short cellular processes localized directly on the cell body while ketamine treatment (inhibition of NMDA-R) facilitated

  12. Limit Distributions for Generalized Ji(r)ina Processes with Immigration

    Institute of Scientific and Technical Information of China (English)

    Yu Qiang LI

    2011-01-01

    A relationship between continuous state population-size-dependent branching(CSDB)processes with or without immigration and discrete state population-size-dependent branching(DSDB)processes with or without immigration is established via the representation of the former.Based on this relationship,some limiting distributions of CSDB processes with or without immigration are obtained.

  13. Cotranscription and processing of 23S, 4.5S and 5S rRNA in chloroplasts from Zea mays.

    OpenAIRE

    Strittmatter, G; Kössel, H

    1984-01-01

    The termini of rRNA processing intermediates and of mature rRNA species encoded by the 3' terminal region of 23S rDNA, by 4.5S rDNA, by the 5' terminal region of 5S rDNA and by the 23S/4.5S/5S intergenic regions from Zea mays chloroplast DNA were determined by using total RNA isolated from maize chloroplasts and 32P-labelled rDNA restriction fragments of these regions for nuclease S1 and primer extension mapping. Several processing sites detectable by both 3' and 5' terminally labelled probes...

  14. Cotranscription and processing of 23S, 4.5S and 5S rRNA in chloroplasts from Zea mays.

    OpenAIRE

    Strittmatter, G; Kössel, H.

    1984-01-01

    The termini of rRNA processing intermediates and of mature rRNA species encoded by the 3' terminal region of 23S rDNA, by 4.5S rDNA, by the 5' terminal region of 5S rDNA and by the 23S/4.5S/5S intergenic regions from Zea mays chloroplast DNA were determined by using total RNA isolated from maize chloroplasts and 32P-labelled rDNA restriction fragments of these regions for nuclease S1 and primer extension mapping. Several processing sites detectable by both 3' and 5' terminally labelled probes...

  15. R&D for the Post-EP Processes of Superconducting RF Cavity

    Energy Technology Data Exchange (ETDEWEB)

    Saeki, Takayuki [KEK; Funahashi, Y. [KEK; Hayano, H. [KEK; Kato, Seigo [KEK; Nishiwaki, Michiru [KEK; Sawabe, Motoaki [KEK; Ueno, Kenji [KEK; Watanabe, K. [KEK; Antoine, Claire [CEA, Gif-sur-Yvette; Berry, Stefurn [CEA, Gif-sur-Yvette; Eozenou, F. [CEA, Gif-sur-Yvette; Gasser, Y. [CEA, Gif-sur-Yvette; Visentin, B. [CEA, Gif-sur-Yvette; Clemens, William A. [JLAB; Geng, Rongli [JLAB; Manus, Robert [JLAB; Tyagi, Puneet [GUAS/AS, Ibaraki

    2009-11-01

    The Electro-Polishing (EP) process is the best candidate of final surface treatment for the production of ILC cavities. Nevertheless, the broad distribution of the gradient caused by field emitters in cavities is sitll a serious problem for the EP process. A candidate source of field emitter is the sulfur component which is produced in the EP process and remains the inner-surface of cavities. We studied the effect of Ethanole- and degreaser-rinse processes after the EP process by a unique method. Moreover, we tried to test the sponge cleaning as the post-EP process to remove the field emitter inside the cavcity. This article describe the results of series tests of the post-EP process at KEK.

  16. 16S rRNA gene sequencing as a tool to study microbial populations in foods and process environments

    DEFF Research Database (Denmark)

    Buschhardt, Tasja; Hansen, Tina Beck; Bahl, Martin Iain

    2015-01-01

    and their role in food safety. During method optimization, we have identified several factors which distort the characterization of microbial populations, including DNA extraction methods, DNA polymerases, and most importantly the analyzed fragment of the 16S rRNA gene. Methods: This study investigated microbial...... reference. Results: Taxonomic assignments and abundances of sequences in the total community and in the Enterobacteriaceae subpopulation were affected by the 16S rRNA gene variable region, DNA extraction methods, and polymerases chosen. However, community compositions were very reproducible when the same......Introduction: Methodological constraints during culturing and biochemical testing have left the true microbiological diversity of foods and process environments unexplored. Culture-independent molecular methods, such as 16S rRNA gene sequencing, may provide deeper insight into microbial communities...

  17. Processing and Properties of R801 Resin for RTM%RTM 用 R801树脂工艺及性能

    Institute of Scientific and Technical Information of China (English)

    孙宝岗; 邓火英; 林治峰; 谭朝元; 谭珏

    2012-01-01

    Curing behavior and processing of a novel BMI resin ( R801) for RTM were investigated. The mechanical properties. Carbon fiber reinforced BMI composites were also studied. DSC results indicated that the curing temperature of this resin ranged from 170℃ to 220℃. There is a low viscosity platform longer than 7 hours due to the soft rise of the resin' s viscosity from 70 to 120℃ the viscosity-to-temperature curves. Sufficient processing time longer than 10 hours is possible with the initial viscosity below 100 mPa·s at the temperature about 90℃. According to the testing mechanical properties, excellent heat-resistant property could also be obtained for the composites using it as the matrix,and mechanical properties retention is above 63% when tested at 300℃.%对一种新型RTM用双马来酰亚胺树脂R801的固化反应特性、成型工艺及其制备的复合材料性能进行了研究,DSC曲线表明该树脂体系的固化温度为170~220℃;黏度随温度变化曲线表明在70~120℃,树脂黏度增长缓慢,具有不少于7h的适用期;在90℃左右时,其初始黏度<100 mPa·s,工艺操作窗口时间≥10h;该树脂制备的 MT300 碳纤维复合材料在300℃时的压缩、弯曲、层剪性能保持率均≥63%.

  18. The Hamburg/ESO R-process Enhanced Star survey (HERES): Abundances

    Science.gov (United States)

    Barklem, P. S.; Christlieb, N.; Beers, T. C.; Hill, V.; Holmberg, J.; Marsteller, B.; Rossi, S.; Zickgraf, F.-J.; Bessell, M. S.

    We present the results of analysis of "snapshot" spectra (i.e., R=20,000 and S/N=50 per pixel) of 253 metal-poor halo stars -3.8[Fe/H] obtained in the HERES survey. The spectra are analysed using an automated line profile analysis method based on the Spectroscopy Made Easy (SME) codes of Valenti & Piskunov (1996). Elemental abundances of moderate precision (absolute r.m.s. errors of order 0.25 dex) have been obtained for 22 elements, C, Mg, Al, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Zn, Sr, Y, Zr, Ba, La, Ce, Nd, Sm, and Eu, where detectable. The results are presented and discussed, particularly trends and scatter in the abundance distributions.

  19. Command and Control Workshop: Structures and Processes for R&D Service Delivery

    Science.gov (United States)

    1996-12-01

    Create web site 24. Interchange Canada- increase participation 25. Military to do thesis at DREs 26. Allow exchange ofDS with universities 27. ATMlink...exploites au maximum; et les ameliorations organisationnelles et structurelles seront axees sur Ia simplification des methodes de R&D. Certaines...or real 17. Self-contained or distributed C2 Laboratory: Creative solutions 1. ATM technologies 2. Video conferencing C-7 3. Web pages 4

  20. Study on rheo-diecasting process of 7075R alloys by SA-EMS melt homogenized treatment

    Science.gov (United States)

    Zhihua, G.; Jun, X.; Zhifeng, Z.; Guojun, L.; Mengou, T.

    2016-03-01

    An advanced melt processing technology, spiral annular electromagnetic stirring (SA-EMS) based on the annular electromagnetic stirring (A-EMS) process was developed for manufacturing Al-alloy components with high integrity. The SA-EMS process innovatively combines non-contact electromagnetic stirring and a spiral annular chamber with specially designed profiles to in situ make high quality melt slurry, and intensive forced shearing can be achieved under high shear rate and high intensity of turbulence inside the spiral annular chamber. In this paper, the solidification microstructure and hardness of 7075R alloy die-casting connecting rod conditioned by the SA-EMS melt processing technology were investigated. The results indicate that, the SA-EMS melt processing technology exhibited superior grain refinement and remarkable structure homogeneity. In addition, it can evidently enhance the mechanical performance and reduce the crack tendency.

  1. Inhibitory repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex modulates early affective processing.

    Science.gov (United States)

    Zwanzger, Peter; Steinberg, Christian; Rehbein, Maimu Alissa; Bröckelmann, Ann-Kathrin; Dobel, Christian; Zavorotnyy, Maxim; Domschke, Katharina; Junghöfer, Markus

    2014-11-01

    The dorsolateral prefrontal cortex (dlPFC) has often been suggested as a key modulator of emotional stimulus appraisal and regulation. Therefore, in clinical trials, it is one of the most frequently targeted regions for non-invasive brain stimulation such as repetitive transcranial magnetic stimulation (rTMS). In spite of various encouraging reports that demonstrate beneficial effects of rTMS in anxiety disorders, psychophysiological studies exploring the underlying neural mechanisms are sparse. Here we investigated how inhibitory rTMS influences early affective processing when applied over the right dlPFC. Before and after rTMS or sham stimulation, subjects viewed faces with fearful or neutral expressions while whole-head magnetoencephalography (MEG) was recorded. Due to the disrupted functioning of the right dlPFC, visual processing in bilateral parietal, temporal, and occipital areas was amplified starting at around 90 ms after stimulus onset. Moreover, increased fear-specific activation was found in the right TPJ area in a time-interval between 110 and 170 ms. These neurophysiological effects were reflected in slowed reaction times for fearful, but not for neutral faces in a facial expression identification task while there was no such effect on a gender discrimination control task. Our study confirms the specific and important role of the dlPFC in regulation of early emotional attention and encourages future clinical research to use minimal invasive methods such as transcranial magnetic (TMS) or direct current stimulation (tDCS). Copyright © 2014 Elsevier Inc. All rights reserved.

  2. Primary-process transformations in music оr discourse about the ineffable

    Directory of Open Access Journals (Sweden)

    Zatkalik Miloš

    2015-01-01

    Full Text Available Every artist or the recipient of a work of art temporarily detaches himself or herself from objective reality through a process that psychoanalysts call regression. They unconsciously (reconstruct the experiential world using verbal, visual or auditory form depending on the type of art. The last case involves the deepest creative regression, which involves the most archaic form of presentation: the primary processes of mental functioning. Dream is a typical manifestation of these processes, so the regressive aspect of music can best be demonstrated through isomorphism between music and dream. Auditory representations constituted according to primary processes set powerful affects in motion, thereby securing discharge and producing aesthetic pleasure.

  3. The Influence of Neutrinos on r-Process Nucleosynthesis in the Ejecta of Black Hole-Neutron Star Mergers

    CERN Document Server

    Roberts, Luke F; Duez, Matthew D; Faber, Joshua A; Foucart, Francois; Lombardi, James C; Ning, Sandra; Ott, Christian D; Ponce, Marcelo

    2016-01-01

    During the merger of a black hole and a neutron star, baryonic mass can become unbound from the system. Because the ejected material is extremely neutron-rich, the r-process rapidly synthesizes heavy nuclides as the material expands and cools. In this work, we map general relativistic models of black hole-neutron star (BHNS) mergers into a Newtonian smoothed particle hydrodynamics (SPH) code and follow the evolution of the thermodynamics and morphology of the ejecta until the outflows become homologous. We investigate how the subsequent evolution depends on our mapping procedure and find that the results are robust. Using thermodynamic histories from the SPH particles, we then calculate the expected nucleosynthesis in these outflows while varying the level of neutrino irradiation coming from the postmerger accretion disk. We find that the ejected material robustly produces r-process nucleosynthesis even for unrealistically high neutrino luminosities, due to the rapid velocities of the outflow. Nonetheless, we...

  4. Search for spin-orbit-force reduction at {sup 106,108}Zr around r-process path

    Energy Technology Data Exchange (ETDEWEB)

    Sumikama, T.; Yoshinaga, K. [Department of Physics, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510 (Japan); Watanabe, H. [RIKEN Nishina Center, 2-1 Hirosawa, Wako, Saitama 351-0198 (Japan); and others

    2012-11-12

    Shell gap at the magic number N= 82 is important to reproduce the 2nd peak of r-process abundance. If a spin-orbit force is reduced in a very neutron-rich region, a shell quenching at N= 82 and a new shell closure at N70 are predicted. A shell evolution by the spin-orbit-force reduction can be searched for through the shape evolution of Zr isotopes around an expected double magic nuclei, {sup 110}Zr(Z = 40,N = 70). We performed {beta}-{gamma} and isomer spectroscopy at RIBF to observe low-lying states in {sup 106,108}Zr. The present results indicate a well deformed shape for {sup 106,108}Zr. The drastic reduction of the spin-orbit force most likely does not occur around {sup 110}Zr on an r-process path.

  5. Shell-model half-lives for r-process waiting point nuclei including first-forbidden contributions

    CERN Document Server

    Zhi, Q; Cuenca-García, J J; Langanke, K; Martínez-Pinedo, G; Sieja, K

    2013-01-01

    We have performed large-scale shell-model calculations of the half-lives and neutron-branching probabilities of the r-process waiting point nuclei at the magic neutron numbers N=50, 82, and 126. The calculations include contributions from allowed Gamow-Teller and first-forbidden transitions. We find good agreement with the measured half-lives for the N=50 nuclei with charge numbers Z=28-32 and for the N=82 nuclei 129Ag and 130Cd. The contribution of forbidden transitions reduce the half-lives of the N=126 waiting point nuclei significantly, while they have only a small effect on the half-lives of the N=50 and 82 r-process nuclei.

  6. Precision mass measurements on neutron-rich Zn isotopes and their consequences on the astrophysical r-process

    Energy Technology Data Exchange (ETDEWEB)

    Baruah, Sudarshan

    2008-07-15

    The rapid neutron-capture or the r-process is responsible for the origin of about half of the neutron-rich atomic nuclei in the universe heavier than iron. For the calculation of the abundances of those nuclei, atomic masses are required as one of the input parameters with very high precision. In the present work, the masses of the neutron rich Zn isotopes (A=71 to 81) lying in the r-process path have been measured in the ISOLTRAP experiment at ISOLDE/CERN. The mass of {sup 81}Zn has been measured directly for the rst time. The half-lives of the nuclides ranged from 46.5 h ({sup 72}Zn) down to 290 ms ({sup 81}Zn). In case of all the nuclides, the relative mass uncertainty ({delta}m=m) achieved was in the order of 10{sup -8} corresponding to a 100-fold improvement in precision over previous measurements. (orig.)

  7. Impact of the first-forbidden β decay on the production of A ∼ 195 r-process peak

    Science.gov (United States)

    Nishimura, Nobuya; Podolyák, Zsolt; Fang, Dong-Liang; Suzuki, Toshio

    2016-05-01

    We investigated the effects of first-forbidden transitions in β decays on the production of the r-process A ∼ 195 peak. The theoretical calculated β-decay rates with β-delayed neutron emission were examined using several astrophysical conditions. As the FF decay is dominant in N ∼ 126 neutron-rich nuclei, their inclusion shortens β-decay lifetimes and shifts the abundance peak towards higher masses. Additionally, the inclusion of the β-delayed neutron emission results in a wider abundance peak, and smoothens the mass distribution by removing the odd-even mass staggering. The effects are commonly seen in the results of all adopted astrophysical models. Nevertheless there are quantitative differences, indicating that remaining uncertainty in the determination of half-lives for N = 126 nuclei is still significant in order to determine the production of the r-process peak.

  8. Impact of the first-forbidden $\\beta$ decay on the production of $A \\sim 195$ r-process peak

    CERN Document Server

    Nishimura, Nobuya; Fang, Dong-Liang; Suzuki, Toshio

    2016-01-01

    We investigated the effects of first-forbidden transitions in $\\beta$ decays on the production of the r-process $A \\sim 195$ peak. The theoretical calculated $\\beta$-decay rates with $\\beta$-delayed neutron emission were examined using several astrophysical conditions. As the first-borbidden decay is dominant in $N \\sim 126$ neutron-rich nuclei, their inclusion shortens $\\beta$-decay lifetimes and shifts the abundance peak towards higher masses. Additionally, the inclusion of the $\\beta$-delayed neutron emission results in a wider abundance peak, and smoothens the mass distribution by removing the odd-even mass staggering. The effects are commonly seen in the results of all adopted astrophysical models. Nevertheless there are quantitative differences, indicating that remaining uncertainty in the determination of half-lives for $N=126$ nuclei is still significant in order to determine the production of the r-process peak.

  9. Impact of the first-forbidden β decay on the production of A∼195 r-process peak

    Directory of Open Access Journals (Sweden)

    Nobuya Nishimura

    2016-05-01

    Full Text Available We investigated the effects of first-forbidden transitions in β decays on the production of the r-process A∼195 peak. The theoretical calculated β-decay rates with β-delayed neutron emission were examined using several astrophysical conditions. As the FF decay is dominant in N∼126 neutron-rich nuclei, their inclusion shortens β-decay lifetimes and shifts the abundance peak towards higher masses. Additionally, the inclusion of the β-delayed neutron emission results in a wider abundance peak, and smoothens the mass distribution by removing the odd–even mass staggering. The effects are commonly seen in the results of all adopted astrophysical models. Nevertheless there are quantitative differences, indicating that remaining uncertainty in the determination of half-lives for N=126 nuclei is still significant in order to determine the production of the r-process peak.

  10. Using the ACT-R architecture to specify 39 quantitative process models of decision making

    NARCIS (Netherlands)

    Marewski, Julian N.; Mehlhorn, Katja

    Hypotheses about decision processes are often formulated qualitatively and remain silent about the interplay of decision, memorial, and other cognitive processes. At the same time, existing decision models are specified at varying levels of detail, making it difficult to compare them. We provide a

  11. Using the ACT-R architecture to specify 39 quantitative process models of decision making

    NARCIS (Netherlands)

    Marewski, Julian N.; Mehlhorn, Katja

    2011-01-01

    Hypotheses about decision processes are often formulated qualitatively and remain silent about the interplay of decision, memorial, and other cognitive processes. At the same time, existing decision models are specified at varying levels of detail, making it difficult to compare them. We provide a m

  12. DD3R zeolite membranes in separation and catalytic processes: Modelling and application

    NARCIS (Netherlands)

    Van den Bergh, J.

    2010-01-01

    Around 2004 the annual energy consumption of the Dutch (petro-)chemical industry was estimated to be 460 PJ of which 200 PJ could be allocated to separation processes [1]. In 2009, 15% of the global energy consumption was required for separation and purification processes to produce commodities. Mor

  13. DD3R zeolite membranes in separation and catalytic processes: Modelling and application

    NARCIS (Netherlands)

    Van den Bergh, J.

    2010-01-01

    Around 2004 the annual energy consumption of the Dutch (petro-)chemical industry was estimated to be 460 PJ of which 200 PJ could be allocated to separation processes [1]. In 2009, 15% of the global energy consumption was required for separation and purification processes to produce commodities.

  14. Dosimetry in radiation processing in the U.S.S.R.

    Science.gov (United States)

    Generalova, V. V.; Gurskii, M. N.; Pikaev, A. K.

    The paper is devoted to the methods of dosimetry used in radiation processing in the USSR. The information on film, solid state and liquid dosimeters is presented. The special attention is paid to the dosimeters that are lot produced. The examples of the application of dosimeters in different radiation technological processes are described. The aspects of standartization of dosimetric measurements are discussed.

  15. R-HPDC Process with Forced Convection Mixing Device for Automotive Part of A380 Aluminum Alloy

    Directory of Open Access Journals (Sweden)

    Bing Zhou

    2014-04-01

    Full Text Available The continuing quest for cost-effective and complex shaped aluminum castings with fewer defects for applications in the automotive industries has aroused the interest in rheological high pressure die casting (R-HPDC. A new machine, forced convection mixing (FCM device, based on the mechanical stirring and convection mixing theory for the preparation of semisolid slurry in convenience and functionality was proposed to produce the automotive shock absorber part by R-HPDC process. The effect of barrel temperature and rotational speed of the device on the grain size and morphology of semi-solid slurry were extensively studied. In addition, flow behavior and temperature field of the melt in the FCM process was investigated combining computational fluid dynamics simulation. The results indicate that the microstructure and pore defects at different locations of R-HPDC casting have been greatly improved. The vigorous fluid convection in FCM process has changed the temperature field and composition distribution of conventional solidification. Appropriately increasing the rotational speed can lead to a uniform temperature filed sooner. The lower barrel temperature leads to a larger uniform degree of supercooling of the melt that benefits the promotion of nucleation rate. Both of them contribute to the decrease of the grain size and the roundness of grain morphology.

  16. Spectroscopic Studies of Extremly Metal-Poor Stars with Subaru/HDS:II.The r-process Elements, Including Thorium

    CERN Document Server

    Honda, S; Kajino, T; Ando, H; Beers, T C; Izumiura, H; Sadakane, K; Takada-Hidai, M

    2004-01-01

    We present the abundance analyses for the neutron-capture elements, and discuss the observed abundance distributions in very metal-poor stars with excesses of r-process elements. As has been found by previous abundance studies, the star-to-star scatter in the abundances of neutron-capture elements are very large. The abundance patterns of the heavy neutron-capture elements (56 $\\leq$ Z $\\leq$ 70) in seven objects with moderate to large excesses of the neutron-capture elements are similar to that of the solar system r-process component. These results strongly suggest that the heavy neutron-capture elements in these objects are primarily synthesized by the r-process. On the other hand, the abundance ratios of the light neutron-capture elements (38 $\\leq$ Z $\\leq$ 46) exhibit a rather large dispersion. Our inspection of the correlation between Sr and Ba abundances in very metal-poor stars reveals that the dispersion of the Sr abundances clearly decreases with increasing Ba abundance. This results support previou...

  17. Detection of Elements at All Three r-process Peaks in the Metal-Poor Star HD 160617

    CERN Document Server

    Roederer, Ian U; 10.1088/0004-637X/750/1/76

    2012-01-01

    We report the first detection of elements at all three r-process peaks in the metal-poor halo star HD 160617. These elements include arsenic and selenium, which have not been detected previously in halo stars, and the elements tellurium, osmium, iridium, and platinum, which have been detected previously. Absorption lines of these elements are found in archive observations made with the Space Telescope Imaging Spectrograph onboard the Hubble Space Telescope. We present up-to-date absolute atomic transition probabilities and complete line component patterns for these elements. Additional archival spectra of this star from several ground-based instruments allow us to derive abundances or upper limits of 45 elements in HD 160617, including 27 elements produced by neutron-capture reactions. The average abundances of the elements at the three r-process peaks are similar to the predicted solar system r-process residuals when scaled to the abundances in the rare earth element domain. This result for arsenic and selen...

  18. PRETREATMENT AND FRACTIONATION OF CORN STOVER BY AMMONIA RECYCLE PERCOLATION PROCESS. (R831645)

    Science.gov (United States)

    Corn stover was pretreated with aqueous ammonia in a flow-through column reactor,a process termed as Ammonia Recycle Percolation (ARP). The aqueous ammonia causesswelling and efficient delignification of biomass at high temperatures. The ARPprocess solubilizes abou...

  19. Nanohole and dot patterning processes on quartz substrate by R-θ electron beam lithography and nanoimprinting

    Science.gov (United States)

    Watanabe, Tsuyoshi; Taniguchi, Kazutake; Suzuki, Kouta; Iyama, Hiromasa; Kishimoto, Shuji; Sato, Takashi; Kobayashi, Hideo

    2016-06-01

    Fine hole and dot patterns with bit pitches (bp’s) of less than 40 nm were fabricated in the circular band area of a quartz substrate by R-θ electron beam lithography (EBL), reactive ion etching (RIE), and nanoimprinting. These patterning processes were studied to obtain minimum pitch sizes of hole and dot patterns without pattern collapse. The patterning on the circular band was aimed to apply these patterning processes to future high-density bit-patterned media (BPM) for hard disk drive (HDD) and permanent memory for the long life archiving of digital data. In hole patterning, a minimum-22-nm-bp and 8.2-nm-diameter pattern (1.3 Tbit/in.2) was obtained on a quartz substrate by optimizing the R-θ EBL and RIE processes. Dot patterns were replicated on another quartz substrate by nanoimprinting using a hole-patterned quartz substrate as a master mold followed by RIE. In dot patterning, a minimum-30-nm-bp and 18.5-nm-diameter pattern (0.7 Tbit/in.2) was obtained by introducing new descum conditions. It was observed that the minimum bp of successful patterning increased as the fabrication process proceeded, i.e., from 20 nm bp in the first EBL process to 30 nm bp in the last quartz dot patterning process. From the measured diameters of the patterns, it was revealed that pattern collapse was apt to occur when the value of average diameter plus 3 sigma of diameter was close to the bp. It was suggested that multiple fabrication processes caused the degradation of pattern quality; therefore, hole patterning is more suitable than dot patterning for future applications owing to the lower quality degradation by its simple fabrication process.

  20. Heat Transfer of Boiling R134a and R142b on a Twisted Tube with Machine Processed Porous Surface%R134a和R142b在表面多孔螺旋扁管外的沸腾传热

    Institute of Scientific and Technical Information of China (English)

    高学农; 尹辉斌; 黄玉优; 凌双梅; 张正国; 方玉堂

    2008-01-01

    The objective of this work was to investigate nucleate pool boiling heat transfer performance and mechanism of R134a and R142b on a twisted tube with machine processed porous surface (T-MPPS tube) as well as to determine its potential application to flooded refrigerant evaporators. In the experimental range, the boiling heat transfer coefficients of R134a on a T-MPPS tube were 1.8-2.0 times larger than those of R134a on a plain tube. In addition, the developed experimental correlations verified that the predictions of the heat transfer coefficients of boiling R134a and R142b on a T-MPPS tube at the experimental conditions were considerably accurate.

  1. Chemistry of the Sagittarius Dwarf Galaxy: a Top-Light IMF, Outflows and the R-Process

    CERN Document Server

    McWilliam, Andrew; Mottini, Marta

    2013-01-01

    From chemical abundance analysis of stars in the Sagittarius dwarf spheroidal galaxy (Sgr), we conclude that the alpha-element deficiencies cannot be due to the Type Ia supernova (SNIa) time-delay scenario of Tinsley (1979). Instead, the evidence points to low [alpha/Fe] ratios resulting from an initial mass function (IMF) deficient in the highest mass stars. The critical evidence is the 0.4 dex deficiency of [O/Fe], [Mg/Fe] and other hydrostatic elements, contrasting with the normal trend of r-process [Eu/Fe]r with [Fe/H]. Supporting evidence comes from the hydrostatic element (O, Mg, Na, Al, Cu) [X/Fe] ratios, which are inconsistent with iron added to the Milky Way (MW) disk trends. Also, the ratio of hydrostatic to explosive (Si, Ca, Ti) element abundances suggests a relatively top-light IMF. Abundance similarities with the LMC, Fornax and IC 1613, suggest that their alpha-element deficiencies also resulted from IMFs lacking the most massive SNII. For such a top-light IMF, the normal trend of r-process [Eu...

  2. Chemistry of the Sagittarius dwarf galaxy: A top-light initial mass function, outflows, and the R-process

    Energy Technology Data Exchange (ETDEWEB)

    McWilliam, Andrew [The Observatories of the Carnegie Institute of Washington, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); Wallerstein, George; Mottini, Marta, E-mail: andy@obs.carnegiescience.edu, E-mail: walleg@u.washington.edu [Astronomy Department, University of Washington, Seattle, WA 98195 (United States)

    2013-12-01

    From chemical abundance analysis of stars in the Sagittarius dwarf spheroidal galaxy (Sgr), we conclude that the α-element deficiencies cannot be due to the Type Ia supernova (SN Ia) time-delay scenario of Tinsley. Instead, the evidence points to low [α/Fe] ratios resulting from an initial mass function (IMF) deficient in the highest mass stars. The critical evidence is the 0.4 dex deficiency of [O/Fe], [Mg/Fe], and other hydrostatic elements, contrasting with the normal trend of r-process [Eu/Fe] {sub r} with [Fe/H]. Supporting evidence comes from the hydrostatic element (O, Mg, Na, Al, Cu) [X/Fe] ratios, which are inconsistent with iron added to the Milky Way (MW) disk trends. Also, the ratio of hydrostatic to explosive (Si, Ca, Ti) element abundances suggests a relatively top-light IMF. Abundance similarities with the LMC, Fornax, and IC 1613 suggest that their α-element deficiencies also resulted from IMFs lacking the most massive SNe II. The top-light IMF, as well as the normal trend of r-process [Eu/Fe] {sub r} with [Fe/H] in Sgr, indicates that massive SNe II (≳30 M {sub ☉}) are not major sources of r-process elements. High [La/Y] ratios, consistent with leaky-box chemical evolution, are confirmed but ∼0.3 dex larger than theoretical asymptotic giant branch (AGB) predictions. This suggests that a substantial increase in the theoretical {sup 13}C pocket in low-mass AGB stars is required. Sgr has the lowest [Rb/Zr] ratios known, consistent with pollution by low-mass (≲2 M {sub ☉}) AGB stars near [Fe/H] = –0.6, likely resulting from leaky-box chemical evolution. The [Cu/O] trends in Sgr and the MW suggest that Cu yields increase with both metallicity and stellar mass, as expected from Cu production by the weak s-process in massive stars. Finally, we present an updated hyperfine splitting line list, an abundance analysis of Arcturus, and further develop our error analysis formalism.

  3. Performance and Model Calibration of R-D-N Processes in Pilot Plant

    DEFF Research Database (Denmark)

    de la Sota, A.; Larrea, L.; Novak, L.

    1994-01-01

    This paper deals with the first part of an experimental programme in a pilot plant configured for advanced biological nutrient removal processes treating domestic wastewater of Bilbao. The IAWPRC Model No.1 was calibrated in order to optimize the design of the full-scale plant. In this first phas...

  4. Molecular diversity of eukaryotes in municipal wastewater treatment processes as revealed by 18S rRNA gene analysis.

    Science.gov (United States)

    Matsunaga, Kengo; Kubota, Kengo; Harada, Hideki

    2014-01-01

    Eukaryotic communities involved in sewage treatment processes have been investigated by morphological identification, but have not yet been well-characterized using molecular approaches. In the present study, eukaryotic communities were characterized by constructing 18S rRNA gene clone libraries. The phylogenetic affiliations of a total of 843 clones were Alveolata, Fungi, Rhizaria, Euglenozoa, Stramenopiles, Amoebozoa, and Viridiplantae as protozoans and Rotifera, Gastrotricha, and Nematoda as metazoans. Sixty percent of the clones had <97% sequence identity to described eukaryotes, indicating the greater diversity of eukaryotes than previously recognized. A core OTU closely related to Epistylis chrysemydis was identified, and several OTUs were shared by 4-8 libraries. Members of the uncultured lineage LKM11 in Cryptomycota were predominant fungi in sewage treatment processes. This comparative study represents an initial step in furthering understanding of the diversity and role of eukaryotes in sewage treatment processes.

  5. Determination of the Neutron-Capture Rate of 17C for the R-process Nucleosynthesis

    CERN Document Server

    Heine, M; Wu, M -R; Adachi, T; Aksyutina, Y; Alcantara, J; Altstadt, S; Alvarez-Pol, H; Ashwood, N; Aumann, T; Avdeichikov, V; Barr, M; Beceiro-Novo, S; Bemmerer, D; Benlliure, J; Bertulani, C A; Boretzky, K; Borge, M J G; Burgunder, G; Caamano, M; Caesar, C; Casarejos, E; Catford, W; Cederkäll, J; Chakraborty, S; Chartier, M; Chulkov, L V; Cortina-Gil, D; Crespo, R; Pramanik, U Datta; Fernandez, P Diaz; Dillmann, I; Elekes, Z; Enders, J; Ershova, O; Estrade, A; Farinon, F; Fraile, L M; Freer, M; Freudenberger, M; Fynbo, H O U; Galaviz, D; Geissel, H; Gernhäuser, R; Göbel, K; Golubev, P; Diaz, D Gonzalez; Hagdahl, J; Heftrich, T; Heil, M; Heinz, A; Henriques, A; Holl, M; Ickert, G; Ignatov, A; Jakobsson, B; Johansson, H T; Jonson, B; Kalantar-Nayestanaki, N; Kanungo, R; Kelic-Heil, A; Knöbel, R; Kröll, T; Krücken, R; Kurcewicz, J; Kurz, N; Labiche, M; Langer, C; Bleis, T Le; Lemmon, R; Lepyoshkina, O; Lindberg, S; Machado, J; Marganiec, J; Martínez-Pinedo, G; Maroussov, V; Mostazo, M; Movsesyan, A; Najafi, A; Neff, T; Nilsson, T; Nociforo, C; Panin, V; Paschalis, S; Perea, A; Petri, M; Pietri, S; Plag, R; Prochazka, A; Rahaman, A; Rastrepina, G; Reifarth, R; Ribeiro, G; Ricciardi, M V; Rigollet, C; Riisager, K; Röder, M; Rossi, D; del Rio, J Sanchez; Savran, D; Scheit, H; Simon, H; Sorlin, O; Stoica, V; Streicher, B; Taylor, J T; Tengblad, O; Terashima, S; Thies, R; Togano, Y; Uberseder, E; Van de Walle, J; Velho, P; Volkov, V; Wagner, A; Wamers, F; Weick, H; Weigand, M; Wheldon, C; Wilson, G; Wimmer, C; Winfield, J S; Woods, P; Yakorev, D; Zhukov, M V; Zilges, A; Zuber, K

    2016-01-01

    With the R$^{3}$B-LAND setup at GSI we have measured exclusive relative-energy spectra of the Coulomb dissociation of $^{18}$C at a projectile energy around 425~AMeV on a lead target, which are needed to determine the radiative neutron-capture cross sections of $^{17}$C into the ground state of $^{18}$C. Those data have been used to constrain theoretical calculations for transitions populating excited states in $^{18}$C. This allowed to derive the astrophysical cross section $\\sigma^{*}_{\\mathrm{n}\\gamma}$ accounting for the thermal population of $^{17}$C target states in astrophysical scenarios. The experimentally verified capture rate is significantly lower than those of previously obtained Hauser-Feshbach estimations at temperatures $T_{9}\\leq{}1$~GK. Network simulations with updated neutron-capture rates and hydrodynamics according to the neutrino-driven wind model as well as the neutron-star merger scenario reveal no pronounced influence of neutron capture of $^{17}$C on the production of second- and thi...

  6. The sub-nucleolar localization of PHF6 defines its role in rDNA transcription and early processing events

    Science.gov (United States)

    Todd, Matthew A M; Huh, Michael S; Picketts, David J

    2016-01-01

    Ribosomal RNA synthesis occurs in the nucleolus and is a tightly regulated process that is targeted in some developmental diseases and hyperactivated in multiple cancers. Subcellular localization and immunoprecipitation coupled mass spectrometry demonstrated that a proportion of plant homeodomain (PHD) finger protein 6 (PHF6) protein is localized within the nucleolus and interacts with proteins involved in ribosomal processing. PHF6 sequence variants cause Börjeson–Forssman–Lehmann syndrome (BFLS, MIM#301900) and are also associated with a female-specific phenotype overlapping with Coffin–Siris syndrome (MIM#135900), T-cell acute lymphoblastic leukemia (MIM#613065), and acute myeloid leukemia (MIM#601626); however, very little is known about its cellular function, including its nucleolar role. HEK 293T cells were treated with RNase A, DNase I, actinomycin D, or 5,6-dichloro-β-D-ribofuranosylbenzimadole, followed by immunocytochemistry to determine PHF6 sub-nucleolar localization. We observed RNA-dependent localization of PHF6 to the sub-nucleolar fibrillar center (FC) and dense fibrillar component (DFC), at whose interface rRNA transcription occurs. Subsequent ChIP-qPCR analysis revealed strong enrichment of PHF6 across the entire rDNA-coding sequence but not along the intergenic spacer (IGS) region. When rRNA levels were quantified in a PHF6 gain-of-function model, we observed an overall decrease in rRNA transcription, accompanied by a modest increase in repressive promoter-associated RNA (pRNA) and a significant increase in the expression levels of the non-coding IGS36RNA and IGS39RNA transcripts. Collectively, our results demonstrate a role for PHF6 in carefully mediating the overall levels of ribosome biogenesis within a cell. PMID:27165002

  7. RAVE J203843.2-002333: The First Highly R-process-enhanced Star Identified in the RAVE Survey

    Science.gov (United States)

    Placco, Vinicius M.; Holmbeck, Erika M.; Frebel, Anna; Beers, Timothy C.; Surman, Rebecca A.; Ji, Alexander P.; Ezzeddine, Rana; Points, Sean D.; Kaleida, Catherine C.; Hansen, Terese T.; Sakari, Charli M.; Casey, Andrew R.

    2017-07-01

    We report the discovery of RAVE J203843.2-002333, a bright (V = 12.73), very metal-poor ([{Fe}/{{H}}] = -2.91), r-process-enhanced ([{Eu}/{Fe}] = +1.64 and [{Ba}/{Eu}] = -0.81) star selected from the RAVE survey. This star was identified as a metal-poor candidate based on its medium-resolution (R ˜ 1600) spectrum obtained with the KPNO/Mayall Telescope, and followed up with high-resolution (R ˜ 66,000) spectroscopy with the Magellan/Clay Telescope, allowing for the determination of elemental abundances for 24 neutron-capture elements, including thorium and uranium. RAVE J2038-0023 is only the fourth metal-poor star with a clearly measured U abundance. The derived chemical abundance pattern exhibits good agreement with those of other known highly r-process-enhanced stars, and evidence suggests that it is not an actinide-boost star. Age estimates were calculated using U/X abundance ratios, yielding a mean age of 13.0 ± 1.1 Gyr. Based on observations gathered with the 6.5 m Magellan Telescopes located at Las Campanas Observatory, Chile; Kitt Peak National Observatory, National Optical Astronomy Observatory (NOAO Prop. ID: 14B-0231; PI: Placco), which is operated by the Association of Universities for Research in Astronomy (AURA) under cooperative agreement with the National Science Foundation. The authors are honored to be permitted to conduct astronomical research on Iolkam Du’ag (Kitt Peak), a mountain with particular significance to the Tohono O’odham.

  8. Data Processing Algorithms in Wireless Sensor Networks får Structural Health Monitoring

    OpenAIRE

    Danna, Nigatu Mitiku; Mekonnen, Esayas Getachew

    2012-01-01

    The gradual deterioration and failure of old buildings, bridges and other civil engineering structures invoked the need for Structural Health Monitoring (SHM) systems to develop a means to monitor the health of structures. Dozens of sensing, processing and monitoring mechanisms have been implemented and widely deployed with wired sensors. Wireless sensor networks (WSNs), on the other hand, are networks of large numbers of low cost wireless sensor nodes that communicate through a wireless medi...

  9. Development of cognitive processes inschoolchildren with learning difficulties inthe light ofanalysis ofWISC-R results

    Directory of Open Access Journals (Sweden)

    Joanna Mazurkiewicz-Gronowska

    2012-09-01

    Full Text Available For several years now, noticeable has been a significant increase in the interest of psychologists – practitioners and scientists, of parents and teachers in the issues of dyslexia, dyscalculia, and other developmental disorders. Specific learning difficulties constitute one of the most prevalent causes of reporting children to psychological and pedagogic outpatient departments. The results of the performed studies enable inter- and intra-group comparisons as well as a global analysis of the structure of intellectual development in children with various learning difficulties. This leads to interesting conclusions and allows for comprehensive scientific discussions. The subject of the article is presentation of the results of studies and conclusions formulated according to them, about the structure of intellectual development of children with learning difficulties diagnosed in two psychological-pedagogic outpatient departments in Lublin region (Psychological-Pedagogic Outpatient Department No 5 in Lublin and PsychologicalPedagogic Outpatient Department No 2 in Zamość. Analysed were the results of the WISC-R scale obtained by schoolchildren from forms IV-VI of elementary schools and junior secondary schools in Lublin and schools of Zamość county. As scholastic difficulties constitute quite a comprehensive term, generally perceived as problems in acquisition of information and mastering school skills, in our study we take into account the following three groups of schoolchildren: with developmental dyslexia, intelligence lower than average, and specific disorders in arithmetic skills. The performed analyses are aimed at familiarization with the developmental level of the schoolchildren’s cognitive functions and their intellectual skills structure based on a three-factor analysis. Our studies continue earlier analyses, including more comprehensive research areas with larger groups.

  10. Pri-miR-17-92a transcript folds into a tertiary structure and autoregulates its processing.

    Science.gov (United States)

    Chakraborty, Saikat; Mehtab, Shabana; Patwardhan, Anand; Krishnan, Yamuna

    2012-05-01

    MicroRNAs control gene expression either by RNA transcript degradation or translational repression. Expressions of miRNAs are highly regulated in tissues, disruption of which leads to disease. How this regulation is achieved and maintained is still largely unknown. MiRNAs that reside on clustered or polycistronic transcripts represent a more complex case where individual miRNAs from a cluster are processed with different efficiencies despite being cotranscribed. To shed light on the regulatory mechanisms that might be operating in these cases, we considered the long polycistronic primary miRNA transcript pri-miR-17-92a that contains six miRNAs with diverse functions. The six miRNA domains on this cluster are differentially processed to produce varying amounts of resultant mature miRNAs in different tissues. How this is achieved is not known. We show, using various biochemical and biophysical methods coupled with mutational studies, that pri-miR-17-92a adopts a specific three-dimensional architecture that poses a kinetic barrier to its own processing. This tertiary structure could create suboptimal protein recognition sites on the pri-miRNA cluster due to higher-order structure formation.

  11. Evaluation of the hygiene status in several meat and dairy processing establishments in R. Macedonia

    Directory of Open Access Journals (Sweden)

    Ratkova Marija

    2013-09-01

    Full Text Available The hygiene practice is one of the most important aspects in the production of safe food. The effectiveness of the cleaning and disinfection programs can be evaluated by continuous examination of the microbiological counts of the surfaces and hands of the workers by taking swabs.In a period of 6 months, 717 swabs were examined, 600 of them from working surfaces, and 117 from employees hands, by using the standard swabbing technique. From the meat production premises 453 swabs were sampled from surfaces and 94 swab samples from workers hands. At the dairy establishments, 147 swabs were taken from the surfaces and 23 swabs from employees hands. The samples were tested for total bacteria viable count according to ISO 4833:2003 and the enumeration of Enterobacteriaceae according to ISO 21528-2:2004, and after that the results were evaluated in accordance with Directive 471/2001/EEC. Obtained results from the meat processing plants were the following: 15.6% were unacceptable for total viable count (TVC and 7.5% were unacceptable for enumeration of Enterobacteriaceae from the swabs taken from surfaces, and 10.6% and 2.1% respectively from the swabs taken from their workers. The results in the milk processing premises were: 9.5% unacceptable for TVC and 2% unacceptable for enumeration of Enterobacteriaceae from the swabs from their surfaces, and 17.4% and 8.7% respectively from the swabs taken from their workers.The results are indicating that although there is a high level of appropriate hygiene practice in all of the food production premises, there is still a percent of unacceptable results, which suggests a lack of hygiene and can emphasis the need for further improvement of the cleaning and disinfecting techniques especially for the surfaces in the meat processing premises and an improvement in the personal hygiene in the dairy industry.

  12. RadA: A protein involved in DNA damage repair processes of Deinococcus radiodurans R1

    Institute of Scientific and Technical Information of China (English)

    ZHOU Qing; ZHANG Xinjue; XU Hong; XU Bujin; HUA Yuejin

    2006-01-01

    RadA is highly conserved in bacteria and belongs to the RecA/RadA/Rad51 protein superfamily found in bacteria, archaea and eukarya. In Archaea, it plays a critical role in homologous recombination process due to its RecA-like function. In Escherichia coli, it takes part in conjugational recombination and DNA repair but is not as important as that of archaea. Using PSI-BLAST searches, we found that Deinococcus radiodurans RadA had a higher similarity to that of bacteria than archaea and eukarya. Disruption of radA gene in D. radiodurans resulted in a modestly decreased resistance to gamma radiation and ultraviolet, but had no effect on the resistance to hydrogen peroxide. Complementation of the radA disruptant by both E. coli radA and D.radiodurans radA could fully restore its resistance to gamma radiation and ultraviolet irradiation. Further domain function analyses of D. radiodurans RadA showed that the absence of the zinc finger domain resulted in a slightly more sensitive phenotype togamma and UV radiation than that of the radA mutant,while the absence of the Lon protease domain exhibited a slightly increased resistance to gamma and UV radiation. These data suggest that D. radiodurans RadA does play an important role in the DNA damage repair processes and its three different domains have different functions.

  13. The neutron long counter NERO for studies of beta-delayed neutron emission in the r-process

    CERN Document Server

    Pereira, J; Lorusso, G; Santi, P; Couture, A; Daly, J; Del Santo, M; Elliot, T; Goerres, J; Herlitzius, C; Kratz, K -L; Lamm, L O; Lee, H Y; Montes, F; Ouellette, M; Pellegrini, E; Reeder, P; Schatz, H; Schertz, F; Schnorrenberger, L; Smith, K; Stech, E; Strandberg, E; Ugalde, C; Wiescher, M; Woehr, A; 10.1016/j.nima.2010.02.262

    2010-01-01

    The neutron long counter NERO was built at the National Superconducting Cyclotron Laboratory (NSCL), Michigan State University, for measuring beta-delayed neutron-emission probabilities. The detector was designed to work in conjunction with a beta-decay implantation station, so that beta decays and beta-delayed neutrons emitted from implanted nuclei can be measured simultaneously. The high efficiency of about 40%, for the range of energies of interest, along with the small background, are crucial for measuring beta-delayed neutron emission branchings for neutron-rich r-process nuclei produced as low intensity fragmentation beams in in-flight separator facilities.

  14. The neutron long counter NERO for studies of β-delayed neutron emission in the r-process

    Science.gov (United States)

    Pereira, J.; Hosmer, P.; Lorusso, G.; Santi, P.; Couture, A.; Daly, J.; Del Santo, M.; Elliot, T.; Görres, J.; Herlitzius, C.; Kratz, K.-L.; Lamm, L. O.; Lee, H. Y.; Montes, F.; Ouellette, M.; Pellegrini, E.; Reeder, P.; Schatz, H.; Schertz, F.; Schnorrenberger, L.; Smith, K.; Stech, E.; Strandberg, E.; Ugalde, C.; Wiescher, M.; Wöhr, A.

    2010-06-01

    The neutron long counter NERO was built at the National Superconducting Cyclotron Laboratory (NSCL), Michigan State University, for measuring β-delayed neutron-emission probabilities. The detector was designed to work in conjunction with a β-delay implantation station, so that β decays and β-delayed neutrons emitted from implanted nuclei can be measured simultaneously. The high efficiency of about 40%, for the range of energies of interest, along with the small background, are crucial for measuring β-delayed neutron emission branchings for neutron-rich r-process nuclei produced as low intensity fragmentation beams in in-flight separator facilities.

  15. Production cross sections of heavy neutron-rich nuclei approaching the nucleosynthesis r-process path around A =195

    Science.gov (United States)

    Kurtukian-Nieto, T.; Benlliure, J.; Schmidt, K.-H.; Audouin, L.; Becker, F.; Blank, B.; Casarejos, E.; Farget, F.; Fernández-Ordóñez, M.; Giovinazzo, J.; Henzlova, D.; Jurado, B.; Pereira, J.; Yordanov, O.

    2014-02-01

    In the present work we were able to synthesize and measure with high accuracy the production cross sections of more than 190 heavy neutron-rich nuclei by the in-flight fragmentation of relativistic 208Pb projectiles, 26 of which were produced for the first time. This work has shown that the N =126 region far below the doubly magic 208Pb has become accessible experimentally and represents a step further towards the study of heavy neutron-rich nuclei approaching the r-process waiting point at A =195.

  16. State of the art of R and D in the anaerobic digestion process of municipal solid waste in Europe

    Energy Technology Data Exchange (ETDEWEB)

    Cecchi, F.; Traverso, P.G.; Mata-Alvarez, J.; Clancy, J.; Zaror, C.

    1988-01-01

    The state of the art of R and D in the field of anaerobic digestion of municipal solid waste in Europe is reviewed. A comparison is made of the quality and quantity of refuse produced in different European countries using data available in recent literature. The conclusion to be drawn from this analysis is that in programmes involving demonstration and full scale plants it is necessary to carry out more detailed studies of the process and its control, as well as carrying out further work on the microbiological aspects of anaerobic digestion of municipal solid waste.

  17. IMNGS: A comprehensive open resource of processed 16S rRNA microbial profiles for ecology and diversity studies.

    Science.gov (United States)

    Lagkouvardos, Ilias; Joseph, Divya; Kapfhammer, Martin; Giritli, Sabahattin; Horn, Matthias; Haller, Dirk; Clavel, Thomas

    2016-09-23

    The SRA (Sequence Read Archive) serves as primary depository for massive amounts of Next Generation Sequencing data, and currently host over 100,000 16S rRNA gene amplicon-based microbial profiles from various host habitats and environments. This number is increasing rapidly and there is a dire need for approaches to utilize this pool of knowledge. Here we created IMNGS (Integrated Microbial Next Generation Sequencing), an innovative platform that uniformly and systematically screens for and processes all prokaryotic 16S rRNA gene amplicon datasets available in SRA and uses them to build sample-specific sequence databases and OTU-based profiles. Via a web interface, this integrative sequence resource can easily be queried by users. We show examples of how the approach allows testing the ecological importance of specific microorganisms in different hosts or ecosystems, and performing targeted diversity studies for selected taxonomic groups. The platform also offers a complete workflow for de novo analysis of users' own raw 16S rRNA gene amplicon datasets for the sake of comparison with existing data. IMNGS can be accessed at www.imngs.org.

  18. Chloroplast RNA-Binding Protein RBD1 Promotes Chilling Tolerance through 23S rRNA Processing in Arabidopsis.

    Directory of Open Access Journals (Sweden)

    Shuai Wang

    2016-05-01

    Full Text Available Plants have varying abilities to tolerate chilling (low but not freezing temperatures, and it is largely unknown how plants such as Arabidopsis thaliana achieve chilling tolerance. Here, we describe a genome-wide screen for genes important for chilling tolerance by their putative knockout mutants in Arabidopsis thaliana. Out of 11,000 T-DNA insertion mutant lines representing half of the genome, 54 lines associated with disruption of 49 genes had a drastic chilling sensitive phenotype. Sixteen of these genes encode proteins with chloroplast localization, suggesting a critical role of chloroplast function in chilling tolerance. Study of one of these proteins RBD1 with an RNA binding domain further reveals the importance of chloroplast translation in chilling tolerance. RBD1 is expressed in the green tissues and is localized in the chloroplast nucleoid. It binds directly to 23S rRNA and the binding is stronger under chilling than at normal growth temperatures. The rbd1 mutants are defective in generating mature 23S rRNAs and deficient in chloroplast protein synthesis especially under chilling conditions. Together, our study identifies RBD1 as a regulator of 23S rRNA processing and reveals the importance of chloroplast function especially protein translation in chilling tolerance.

  19. The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, R.N.; Robinson, H.; Klauer, A. A.; Hintze, B. J.; van Hoof, A.; Johnson, S. J.

    2010-07-01

    The essential RNA helicase, Mtr4, performs a critical role in RNA processing and degradation as an activator of the nuclear exosome. The molecular basis for this vital function is not understood and detailed analysis is significantly limited by the lack of structural data. In this study, we present the crystal structure of Mtr4. The structure reveals a new arch-like domain that is specific to Mtr4 and Ski2 (the cytosolic homologue of Mtr4). In vivo and in vitro analyses demonstrate that the Mtr4 arch domain is required for proper 5.8S rRNA processing, and suggest that the arch functions independently of canonical helicase activity. In addition, extensive conservation along the face of the putative RNA exit site highlights a potential interface with the exosome. These studies provide a molecular framework for understanding fundamental aspects of helicase function in exosome activation, and more broadly define the molecular architecture of Ski2-like helicases.

  20. Daring the Challenge and Thinking Big: The Value of Early Process R&D.

    Science.gov (United States)

    Abele, Stefan; Funel, Jacques-Alexis; Schmidt, Gunther; Moessner, Christian; Schwaninger, Mischa; Marti, Roger

    The production of the L/T channel blocker ACT-280778 required the enantiomerically pure 5-phenylbicyclo[2.2.2]oct-5-en-2-one (1) as key building block. As the published routes towards 1 are very low yielding (<0.5% yield) and comprise many steps that are not acceptable for scale-up, a series of processes to 1 was developed to match the increasing requirements from first kg-batches to clinical supplies. The three routes are characterized by an individual asset. (1) The first route contains a scale-up of a Diels-Alder reaction with highly reactive reagents and afforded 90 kg enantiomerically pure 1. To mitigate safety risks, a flow reactor was developed for the high-temperature Diels-Alder reaction. This route relied on an efficient enantiomer separation on a ¼-ton scale by HPLC. (2) A Crystallization Induced Diastereomer Transformation (CIDT) during an intramolecular aldol reaction was the pivotal step of a first enantioselective route that starts with the Shibasaki reaction. (3) The 2(nd) enantioselective route represents a rare example of organocatalysis on scale and allowed to skip six out of nine steps with a significant impact on the cost of goods. This simple way to 1 opened up a short synthesis of Hayashi's chiral diene ligands (bod*) that were so far lacking an affordable access. Some of these novel C1-symmetrical dienes have shown very high enantioselectivities in Rh-catalyzed additions of arylboronates.

  1. Probing the Site for r-Process Nucleosyntheis with Abundances of Barium and Magnesium in Extremely Metal-Poor Stars

    CERN Document Server

    Tsujimoto, T; Yoshii, Y; Tsujimoto, Takuji; Shigeyama, Toshikazu; Yoshii, Yuzuru

    2000-01-01

    We suggest that if the astrophysical site for r-process nucleosynthesis in the early Galaxy is confined to a narrow mass range of Type II supernova (SN II) progenitors, with a lower mass limit of Mms = 20 Msun, a unique feature in the observed distribution of [Ba/Mg] vs.[Mg/H] for extremely metal-poor stars can be adequately reproduced. We associate this feature, a bifurcation of the observed elemental ratios into two branches in the Mg abundance interval -2.7 20 Msun. The second branch, which we call the ``i''-branch, is associated with the elemental abundance ratios of stars which were formed in the dense shells of the interstellar medium swept up by SNe II with Mms < 20 Msun that do not synthesize r-process elements, and applies to stars with observed Mg abundances in the range [Mg/H] < -2.7. The Ba abundances in these stars reflect those of the interstellar gas at the (later) time of their formation. The existence of a [Ba/Mg] i-branch strongly suggests that SNe II which are associated with stars o...

  2. Natal Kicks and Time Delays in Merging Neutron Star Binaries: Implications for r-process Nucleosynthesis in Ultra-faint Dwarfs and in the Milky Way

    Science.gov (United States)

    Beniamini, Paz; Hotokezaka, Kenta; Piran, Tsvi

    2016-09-01

    Merging neutron star binaries are prime candidate sources for heavy r-process nucleosynthesis. The amount of heavy r-process material is consistent with the mass ejection and rates of mergers, and abundances of relic radioactive materials suggest that heavy r-process material is produced in rare events. Observations of possible macronovae provide further support for this model. Still, some concerns remain. One is the observation of heavy r-process elements in ultra-faint dwarf (UFD) galaxies. The escape velocities from UFDs are so small that the natal kicks, taking place at neutron stars’ birth, might eject such binaries from UFDs. Furthermore, the old stellar populations of UFDs require that r-process nucleosynthesis must have taken place very early on, while it may take several Gyr for compact binaries to merge. This last problem arises also within the Milky Way where heavy r-process materials have been observed in some low-metallicity stars. We show here that ≳ 0.5 of neutron star binaries form with a sufficiently small proper motion to remain bound even in a UFD. Furthermore, approximately 90% of double neutron stars with an initial separation of 1011 cm merge within 300 Myr and ≈ 15 % merge in less than 100 Myr. This population of “rapid mergers” explains the appearance of heavy r-process material in both UFDs and in the early Milky Way.

  3. MOLYBDENUM, RUTHENIUM, AND THE HEAVY r-PROCESS ELEMENTS IN MODERATELY METAL-POOR MAIN-SEQUENCE TURNOFF STARS

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, Ruth C. [Astrophysical Advances, 607 Marion Place, Palo Alto, CA 94301 (United States)

    2013-05-01

    The ratios of elemental abundances observed in metal-poor stars of the Galactic halo provide a unique present-day record of the nucleosynthesis products of its earliest stars. While the heaviest elements were synthesized by the r- and s-processes, dominant production mechanisms of light trans-ironic elements were obscure until recently. This work investigates further our 2011 conclusion that the low-entropy regime of a high-entropy wind (HEW) produced molybdenum and ruthenium in two moderately metal-poor turnoff stars that showed extreme overabundances of those elements with respect to iron. Only a few, rare nucleosynthesis events may have been involved. Here we determine abundances for Mo, Ru, and other trans-Fe elements for 28 similar stars by matching spectral calculations to well-exposed near-UV Keck HIRES spectra obtained for beryllium abundances. In each of the 26 turnoff stars with Mo or Ru line detections and no evidence for s-process production (therefore old), we find Mo and Ru to be three to six times overabundant. In contrast, the maximum overabundance is reduced to factors of three and two for the neighboring elements zirconium and palladium. Since the overproduction peaks sharply at Mo and Ru, a low-entropy HEW is confirmed as its origin. The overabundance level of the heavy r-process elements varies significantly, from none to a factor of four, but is uncorrelated with Mo and Ru overabundances. Despite their moderate metallicity, stars in this group trace the products of different nucleosynthetic events: possibly very few events, possibly events whose output depended on environment, metallicity, or time.

  4. miR-34a knockout attenuates cognitive deficits in APP/PS1 mice through inhibition of the amyloidogenic processing of APP.

    Science.gov (United States)

    Jian, Chongdong; Lu, Mengru; Zhang, Zhao; Liu, Long; Li, Xianfeng; Huang, Fang; Xu, Ning; Qin, Lina; Zhang, Qian; Zou, Donghua

    2017-08-01

    The noncoding miRNA-34a (miR-34a) is involved in Alzheimer's disease (AD) pathologenesis and shows potential for application as a biomarker for early diagnosis and intervention. Here, we established miR-34a knockout mice in an APP/PS1 background (APP/PS1-miR-34a KO mice) by crossbreeding miR-34a(-/-) mice with APP/PS1 mice. We then investigated cognitive impairment and related pathologies. The results showed that the level of miR-34a was increased at about 6months in APP/PS1 mice, consistent with the increase in amyloid β (Aβ), and cognitive function was significantly improved in mice when miR-34a was knocked out in 9-month-old and 12-month-old mice, indicating that miR-34a is a potential candidate for determining the progression of AD. Furthermore, we assessed the processing of amyloid precursor protein (APP) and the results suggest that cognitive improvement by miR-34a knock out was mainly triggered by depression of γ-secretase activity, without affecting β- and α-secretase activities, indicating that miR-34a plays an important role in AD pathology, mainly by inhibiting the amyloidogenic processing of APP, without altering the non-amyloidogenic processing of APP. Copyright © 2017. Published by Elsevier Inc.

  5. hUTP24 is essential for processing of the human rRNA precursor at site A1, but not at site A0

    Science.gov (United States)

    Tomecki, Rafal; Labno, Anna; Drazkowska, Karolina; Cysewski, Dominik; Dziembowski, Andrzej

    2015-01-01

    Production of ribosomes relies on more than 200 accessory factors to ensure the proper sequence of steps and faultless assembly of ribonucleoprotein machinery. Among trans-acting factors are numerous enzymes, including ribonucleases responsible for processing the large rRNA precursor synthesized by RNA polymerase I that encompasses sequences corresponding to mature 18S, 5.8S, and 25/28S rRNA. In humans, the identity of most enzymes responsible for individual processing steps, including endoribonucleases that cleave pre-rRNA at specific sites within regions flanking and separating mature rRNA, remains largely unknown. Here, we investigated the role of hUTP24 in rRNA maturation in human cells. hUTP24 is a human homolog of the Saccharomyces cerevisiae putative PIN domain-containing endoribonuclease Utp24 (yUtp24), which was suggested to participate in the U3 snoRNA-dependent processing of yeast pre-rRNA at sites A0, A1, and A2. We demonstrate that hUTP24 interacts to some extent with proteins homologous to the components of the yeast small subunit (SSU) processome. Moreover, mutation in the putative catalytic site of hUTP24 results in slowed growth of cells and reduced metabolic activity. These effects are associated with a defect in biogenesis of the 40S ribosomal subunit, which results from decreased amounts of 18S rRNA as a consequence of inaccurate pre-rRNA processing at the 5′-end of the 18S rRNA segment (site A1). Interestingly, and in contrast to yeast, site A0 located upstream of A1 is efficiently processed upon UTP24 dysfunction. Finally, hUTP24 inactivation leads to aberrant processing of 18S rRNA 2 nucleotides downstream of the normal A1 cleavage site. PMID:26237581

  6. Discovery of a strongly r-process enhanced extremely metal-poor star LAMOST J110901.22+075441.8

    CERN Document Server

    Li, Haining; Honda, Satoshi; Zhao, Gang; Christlieb, Norbert; Suda, Takuma

    2015-01-01

    We report the discovery of an extremely metal-poor (EMP) giant, LAMOST J110901.22+075441.8, which exhibits large excess of r-process elements with [Eu/Fe] ~ +1.16. The star is one of the newly discovered EMP stars identified from LAMOST low-resolution spectroscopic survey and the high-resolution follow-up observation with the Subaru Telescope. Stellar parameters and elemental abundances have been determined from the Subaru spectrum. Accurate abundances for a total of 23 elements including 11 neutron-capture elements from Sr through Dy have been derived for LAMOST J110901.22+075441.8. The abundance pattern of LAMOST J110901.22+075441.8 in the range of C through Zn is in line with the "normal" population of EMP halo stars, except that it shows a notable underabundance in carbon. The heavy element abundance pattern of LAMOST J110901.22+075441.8 is in agreement with other well studied cool r-II metal-poor giants such as CS 22892-052 and CS 31082-001. The abundances of elements in the range from Ba through Dy well...

  7. Detection of low Eu abundances in extremely metal-poor stars and the origin of r-process elements

    CERN Document Server

    Ishimaru, Y; Aoki, W; Ryan, S G; Aoki, Wako; Ishimaru, Yuhri; Ryan, Sean G.; Wanajo, Shinya

    2003-01-01

    We report detailed abundance analyses for three extremely metal-poor stars with [Fe/H] lesssim -3 in the Galactic halo, using the Subaru High Dispersion Spectrograph (HDS). All these stars are found to have sub-solar relative abundances of [Eu/Fe], and exhibit the lowest [Eu/H] values at their metallicities. Comparison of these low Eu abundances with our chemical evolution model of the Galactic halo implies the dominant source of Eu to be the low-mass end of the Type II supernova mass range. This suggests that collapsing O-Ne-Mg cores resulting from 8-10 Msun stars are the major r-process site.

  8. Enhanced Bandwidth and Diversity in Real-Time Analog Signal Processing (R-ASP) using Nonuniform C-section Phasers

    CERN Document Server

    Taravati, Sajjad; Zhang, Qingfeng; Caloz, Christophe

    2016-01-01

    We show that a continuously nonuniform coupled line C-section phaser, as the limiting case of the step discontinuous coupled-line multisection commensurate and non-commensurate phasers, provides enhanced bandwidth and diversity in real-time analog signal processing (R-ASP). The phenomenology of the component is explained in comparison with the step-discontinuous using multiple-reflection theory and a simple synthesis procedure is provided. The bandwidth enhancement results from the suppression of spurious group delay harmonics or quasi-harmonics, while the diversity enhancement results from the greater level of freedom provided by the continuous nature of the nonuniform profile of the phaser. These statements are supported by theoretical and experimental results.

  9. Natal Kicks and Time Delays in Merging Neutron Star Binaries - Implications for r-process nucleosynthesis in Ultra Faint Dwarfs and in the Milky Way

    CERN Document Server

    Beniamini, Paz; Piran, Tsvi

    2016-01-01

    Merging neutron star binaries are prime candidate sources for heavy r-process nucleosynthesis. The amount of heavy r-process material is consistent with the mass ejection and rates of mergers, and abundances of relic radioactive materials suggest that heavy r-process material is produced in rare events. Observations of possible macronovae provide further support for this model. Still, some concerns remain. One is the observation of heavy r-process elements in Ultra Faint Dwarf (UFD) galaxies. The escape velocities from UFDs are so small that the natal kicks, taking place at neutron stars birth, might eject such binaries from UFDs. Furthermore the old stellar populations of UFDs requires that r-process nucleosynthesis must have taken place very early on, while it may take several Gyr for compact binaries to merge. This last problem arises also within the Milky Way where heavy r-process materials has been observed in some low metallicity stars. We show here that since a significant fraction of neutron star bina...

  10. 基于ACTIFLO(R)工艺的预氧化中试研究%Pilot Study of Pre-oxidation Based on ACTIFLO(R) Process

    Institute of Scientific and Technical Information of China (English)

    陈有军; 杨振兴; 虞睿; 李礼; 周大农; 杨敏; 由小卉; 赵欣; 陈晓华

    2011-01-01

    A large drinking water plant in north China has applied ACTIFLO(R) settler successfully for more than 4 years. During the pre-oxidation upgrading, a series of pilot tests based on the existing ACTIFLO(R) settler were carried out to provide guidance for production operation. The study results show that the pre-ozonation can cause the increasing of turbidity at the outlet of settler, and the operation periods of the downstream filters are shortened. The influence of potassium permanganate ( KMnO4) and sodium hypochlorite ( NaClO) on coagulation sedimentation was also studied. It is found that the excessive dosage has a negative impact on coagulation sedimentation, with a higher turbidity at the outlet of settler and shorter operation periods of filters. The comparison of the results shows that each kind of oxidant has different impact on the treated water turbidity. Based on the raw water quality, the dosage of oxidant shall be optimized and the residue concentration shall be controlled at very low level. In this way, a better operation result of ACTIFLO(R) settler can be achieved.%北方某大型净水厂采用了ACTIFL(R)高效沉淀工艺,并已成功运行4年多.在该厂进行预臭氧处理改造过程中,基于现有ACTIFL(R)高效沉淀池中试装置,进行了一系列试验,以期为生产运行提供指导.研究发现,预臭氧氧化会导致沉淀池出水浊度升高,滤池运行周期缩短.此外,还分别研究了净水厂常用的另外两种预氧化剂--高锰酸钾和次氯酸钠对混凝及沉淀过程的影响,发现过量投加同样会对混凝过程产生负面影响,导致沉淀池出水浊度升高及滤池过滤周期缩短.对比发现,各氧化剂的影响程度不同,针对原水水质特性,通过优化氧化剂的投加量以控制其残余量,可以确保ACTIFL(R)工艺的运行效果良好.

  11. Molybdenum, Ruthenium, and the Heavy r-process Elements in Moderately Metal-Poor Main-Sequence Turnoff Stars

    CERN Document Server

    Peterson, Ruth C

    2013-01-01

    The ratios of elemental abundances observed in metal-poor stars of the Galactic halo provide a unique present-day record of the nucleosynthesis products of its earliest stars. While the heaviest elements were synthesized by the r- and s-processes, dominant production mechanisms of light trans-ironic elements were obscure until recently. This work investigates further our 2011 conclusion that the low-entropy regime of a high-entropy wind (HEW) produced molybdenum and ruthenium in two moderately metal-poor turnoff stars that showed extreme overabundances of those elements with respect to iron. Only a few, rare nucleosynthesis events may have been involved. Here we determine abundances for Mo, Ru, and other trans-Fe elements for 28 similar stars by matching spectral calculations to well-exposed near-UV Keck HIRES spectra obtained for beryllium abundances. In each of the 26 turnoff stars with Mo or Ru line detections and no evidence for s-process production (therefore old), we find Mo and Ru to be three to six ti...

  12. Explosive Nucleosynthesis in Magnetohydrodynamical Jets from Collapsars II. Heavy-element nucleosynthesis of s, r, p-processes

    CERN Document Server

    Ono, Masaomi; Fujimoto, Shin-ichiro; Kotake, Kei; Yamada, Shoichi

    2012-01-01

    We investigate the nucleosynthesis in a massive star of 70 M_solar with solar metallicity in the main sequence stage. The helium core mass after hydrogen burning corresponds to 32 M_solar. Nucleosynthesis calculations have been performed during the stellar evolution and the jet-like supernova explosion of a collapsar model. We focus on the production of heavier elements than iron. Nucleosynthesis calculations have been done by using large nuclear reaction networks, where the weak s-, p-, and r-processes are taken into account. We confirm that s-elements of 60 90 are produced via photodisintegrations of seed s-elements. However, the produced p-elements are destructed in later stages except for ^{180}Ta. In the explosive nucleosynthesis, elements of 90 50) are overproduced relative to the solar values via the p-process because of the low peak temperatures in the oxygen and neon-rich layers. We confirm primary synthesis of light p-elements in the ejected matter of high peak temperature. The ejected matter has ...

  13. The Binary Frequency of r-Process-Element Enhanced Metal-Poor Stars and its Implications: Chemical Tagging in the Primitive Halo of the Milky Way

    CERN Document Server

    Hansen, Terese; Nordström, Birgitta; Buchhave, Lars A; Beers, Timothy C

    2011-01-01

    A few rare halo giants in the range [Fe/H] $\\simeq -2.9\\pm0.3$ exhibit {\\it r}-process element abundances that vary as a group by factors up to [$r$/Fe] $\\sim80$, relative to those of the iron peak and below. Yet, the astrophysical production site of these {\\it r}-process elements remains unclear. We report initial results from four years of monitoring the radial velocities of 17 {\\it r}-process-enhanced metal-poor giants to detect and characterise binaries in this sample. We find three (possibly four) spectroscopic binaries with orbital periods and eccentricities that are indistinguishable from those of Population I binaries with giant primaries, and which exhibit no signs that the secondary components have passed through the AGB stage of evolution or exploded as supernovae. The other 14 stars in our sample appear to be single -- including the prototypical $r$-process-element enhanced star CS 22892-052, which is also enhanced in carbon, but not in {\\it s}-process elements. We conclude that the {\\it r}-proces...

  14. R/S AND WAVELET ANALYSIS ON EVOLUTIONARY PROCESS OF REGIONAL ECONOMIC DISPARITY IN CHINA DURING PAST 50 YEARS

    Institute of Scientific and Technical Information of China (English)

    XU Jian-hua; LU Yan; SU Fang-lin; AI Nan-shan

    2004-01-01

    This paper shows the dynamic process of regional disparity of economic development in China in the past 50 years from a new insight by using the rescaled range statistic (R/S) analysis and wavelet analysis of the Theil index sequence with different time scales.The main conclusions are:1) The regional disparity of economic develop ment in China,including the inter-provincial disparity,inter-regional disparity and intra-regional disparity,has exist ed for many years.Theil index by the comparative price has revealed the true trend for comparative disparity of re gional economic development from 1952 to 2000.2) Decomposition of Theil index indicates that the dynamic trend of comparative inter-provincial disparity in the coastal region is in line with dynamic trend of inter-provincial dispar ity in the whole China.3) The R/S analysis results tell us that during 1966-1978,the Hurst exponent H=0.504≈0.5,which indicates that in that period the evolution of comparative inter-provincial disparity of economic development showed a random characteristic,and in the other periods,i.e.1952-1965,1979-1990 and 1991-2000,the Hurst ex ponent H>0.5,which indicates that in those periods the evolution of the comparative inter-provincial disparity of e conomic development in China had a long-enduring characteristic.4) By using wavelet analysis at different time scale,we arrived at a conclusion that the evolutionary process of the disparity of economic development of China is not a simple inverted U shape but a compound of several U shapes.The result tells us that the evolutionary plot of inter-provincial disparity in China follows the inverted U on the whole at the higher scale,24 (16 years).That is to say,the disparity tends to rise in the first stage of economic development,and fall slowly over the peak in the second stage of economic development.However,if we shorten the time scale to 23 (8 years),then a link of several U shapes will appear.

  15. The group I-like ribozyme DiGIR1 mediates alternative processing of pre-rRNA transcripts in Didymium iridis

    DEFF Research Database (Denmark)

    Vader, Anna; Johansen, Steinar; Nielsen, Henrik

    2002-01-01

    During starvation induced encystment, cells of the myxomycete Didymium iridis accumulate a 7.5-kb RNA that is the result of alternative processing of pre-rRNA. The 5' end corresponds to an internal processing site cleaved by the group I-like ribozyme DiGIR1, located within the twin-ribozyme intron...

  16. Propulsion and Power Rapid Response Research and Development (R&D) Support. Task Order 0004: Advanced Propulsion Fuels R&D, Subtask: Optimization of Lipid Production and Processing of Microalgae for the Development of Biofuels

    Science.gov (United States)

    2013-02-01

    Fuels R&D Subtask: Optimization of Lipid Production and Processing of Microalgae for the Development of Biofuels José Colucci, Govind Nadathur...Production and Processing of Microalgae for the Development of Biofuels 5a. CONTRACT NUMBER FA8650-08-D-2806-0004 5b. GRANT NUMBER 5c. PROGRAM...ABSTRACT Microalgae are considered a suitable feedstock to produce biofuels or bio-oils. Some species are known to naturally accumulate large amounts

  17. Role of ($\\alpha$,n) reactions under $r$-process conditions in neutrino-driven winds revisited

    CERN Document Server

    Mohr, Peter

    2016-01-01

    Background: The astrophysical $r$-process occurs in an explosive astrophysical event under extremely neutron-rich conditions, leading to (n,$\\gamma$)-($\\gamma$,n) equilibrium along isotopic chains which peaks around neutron separation energies of a few MeV. Nuclei with larger $Z$ are usually produced by $\\beta^-$-decay, but under certain conditions also $\\alpha$-induced reactions may become relevant for the production of nuclei with $Z+2$. Purpose: The uncertainties of the reaction rates of these $\\alpha$-induced reactions are discussed within the statistical model. As an example, $\\alpha$-induced ($\\alpha$,n) and $(\\alpha$,$x$n) reaction cross sections for the neutron-rich $^{86}$Se nucleus are studied in detail. Method: In a first step, the relevance of ($\\alpha$,n) and $(\\alpha$,$x$n) reactions is analyzed. Next the uncertainties are determined from a variation of the $\\alpha$-nucleus potential which is the all-dominant parameter for the astrophysical $Z \\rightarrow Z+2$ reaction rate. Results: It is found...

  18. Stability beyond the neutron drip-line near the third peak of the r-process nucleosynthesis

    CERN Document Server

    Sharma, M M

    2011-01-01

    We have investigated the nuclear shell effects at N=126 in the region of the third peak of the r-process nucleosynthesis within the framework of the relativistic mean-field theory using the Lagrangian model NL-SV1 with the vector self-coupling of omega-meson. Our study encompasses even-even nuclei with N=110-140 in the isotopic chains of Hf (Z=72) down to Ba (Z=56). It is shown that the nuclear shell effects at N=126 remain strong even as one moves far away from the line of the beta-stability. As the neutron drip line approaches N=126, nuclei exhibit vanishingly small neutron separation energy. However, going beyond the neutron drip line, we observe an interesting feature in that some nuclei near N ~ 132-134 for the isotopic chains of Z=62-68 show enhanced neutron separation energy. This is especially pronounced for the isotopes of Gd (Z=64) and Dy (Z=66). These nuclei exhibit the phenomenon of stability beyond the neutron drip line. Our analysis of the single-particle spectrum shows that this is engendered b...

  19. The Hamburg/ESO R-process Enhanced Star survey (HERES)VII. Thorium abundances in metal-poor stars

    CERN Document Server

    Ren, Jin; Zhao, Gang

    2011-01-01

    We report thorium abundances for 77 metal-poor stars in the metallicity range of -3.5<[Fe/H]}<-1.0, based on "snapshot" spectra obtained with VLT-UT2/UVES during the HERES Survey. We were able to determine the thorium abundances with better than 1-sigma confidence for 17 stars, while for 60 stars we derived upper limits. For five stars common with previous studies, our results were in good agreement with the literature results. The thorium abundances span a wide range of about 4.0 dex, and scatter exists in the distribution of log(Th/Eu) ratios for lower metallicity stars, supporting previous studies suggesting the r-process is not universal. We derived ages from the log(Th/Eu) ratios for 12 stars, resulting in large scattered ages, and two stars with significant enhancement of Th relative to Eu are found, indicating the "actinide boost" does not seem to be a rare phenomenon and thus highlighting the risk in using log(Th/Eu) to derive stellar ages.

  20. [Montérégie Comprehensive Cancer Care Centre: integrating nurse navigators in Montérégie's oncology teams: the process. Part 2].

    Science.gov (United States)

    Plante, Anne; Joannette, Sonia

    2009-01-01

    Quebec's Oncology Nurse Navigators (or "IPOs" after their French acronym) have been integrated in the entire Montérégie health care region. They have been agents of change mandated with implementing a philosophy of care that centres on the patients and their families, and is delivered by oncology teams. The goal of this second article is to describe the role of IPOs in practice, the problems encountered in the various contexts and the solutions brought forward to facilitate their integration. The training of IPOs, the support they receive from administrators, the deployment of interdisciplinary teams dedicated to oncology, the holding of regular structured interdisciplinary meetings and the training of professionals, and development of standardized work instruments are discussed. The observed impacts of introducing IPOs will also be examined.

  1. Aggregation of Ribosomal Protein S6 at Nucleolus Is Cell Cycle-Controlled and Its Function in Pre-rRNA Processing Is Phosphorylation Dependent.

    Science.gov (United States)

    Zhang, Duo; Chen, Hui-Peng; Duan, Hai-Feng; Gao, Li-Hua; Shao, Yong; Chen, Ke-Yan; Wang, You-Liang; Lan, Feng-Hua; Hu, Xian-Wen

    2016-07-01

    Ribosomal protein S6 (rpS6) has long been regarded as one of the primary r-proteins that functions in the early stage of 40S subunit assembly, but its actual role is still obscure. The correct forming of 18S rRNA is a key step in the nuclear synthesis of 40S subunit. In this study, we demonstrate that rpS6 participates in the processing of 30S pre-rRNA to 18S rRNA only when its C-terminal five serines are phosphorylated, however, the process of entering the nucleus and then targeting the nucleolus does not dependent its phosphorylation. Remarkably, we also find that the aggregation of rpS6 at the nucleolus correlates to the phasing of cell cycle, beginning to concentrate in the nucleolus at later S phase and disaggregate at M phase. J. Cell. Biochem. 117: 1649-1657, 2016. © 2015 Wiley Periodicals, Inc.

  2. The New Model of Chemical Evolution of r-process Elements Based on The Hierarchical Galaxy Formation I: Ba and Eu

    CERN Document Server

    Komiya, Yutaka; Suda, Takuma; Fujimoto, Masayuki Y

    2014-01-01

    We investigate the chemical enrichment of r-process elements in the early evolutionary stages of the Milky Way halo within the framework of hierarchical galaxy formation using a semi-analytic merger tree. In this paper, we focus on heavy r-process elements, Ba and Eu, of extremely metal-poor (EMP) stars and give constraints on their astronomical sites. Our models take into account changes of the surface abundances of EMP stars by the accretion of interstellar matter (ISM). We also consider metal-enrichment of intergalactic medium (IGM) by galactic winds and the resultant pre-enrichment of proto-galaxies. The trend and scatter of the observed r-process abundances are well reproduced by our hierarchical model with $\\sim 10\\%$ of core-collapse supernovae in low-mass end ($\\sim 10M_{\\odot}$) as a dominant r-process source and the star formation efficiency of $\\sim 10^{-10} \\hbox{yr}^{-1}$. For neutron star mergers as an r-process source, their coalescence timescale has to be $ \\sim 10^7$yrs, and the event rates $...

  3. A Study of the r-Process Path Nuclides,$^{137,138,139}$Sb using the Enhanced Selectivity of Resonance Ionization Laser Ionization

    CERN Multimedia

    Walters, W

    2002-01-01

    The particular features of the r-process abundances with 100 < A < 150 have demonstrated the close connection between knowledge of nuclear structure and decay along the r-process path and the astrophysical environement in which these elements are produced. Key to this connection has been the measurement of data for nuclides (mostly even-N nuclides) that lie in the actual r-process path. Such data are of direct use in r-process calculations and they also serve to refine and test the predictive power of nuclear models where little or no data now exist. In this experiment we seek to use the newly developed ionization scheme for the Resonance Ionization Laser Ion Source (RILIS) to achieve selective ionization of neutron-rich antimony isotopes in order to measure the decay properties of r-process path nuclides $^{137,138,139}$Sb. These properties include the half-lives, delayed neutron branches, and daughter $\\gamma$-rays. The new nuclear structure data for the daughter Te nuclides is also of considerable in...

  4. Ud af røret? Planer, processer og paradokser omkring det Københavnske kloaksystem 1840-2001

    DEFF Research Database (Denmark)

    Lindegaard, Hanne

    Afhandlingen handler om Københavns mere en 100 år gamle kloakteknologi, der i mange år har været en usynlig, stabil og taken for granted hverdagsinstallation, som ikke i særlig høj grad er blevet diskuteret eller problematiseret, men opfattet som en fuldstændig løsning på en række af byens proble...

  5. Balancing SoNaR: IPR versus Processing Issues in a 500-Million-Word Written Dutch Reference Corpus

    NARCIS (Netherlands)

    Reynaert, Martin; Oostdijk, Nelleke; De Clercq, Orph´ee; van den Heuvel, Henk; de Jong, Franciska M.G.

    2010-01-01

    In The Low Countries, a major reference corpus for written Dutch is beingbuilt. We discuss the interplay between data acquisition and data processingduring the creation of the SoNaR Corpus. Based on developments in traditionalcorpus compiling and new web harvesting approaches, SoNaR is designed toco

  6. Chemical Growth Processes in Titan's Atmosphere: Theoretical Rates and Product Distributions for Reactions between C2H and R1R2C=CR3R4 Species

    Science.gov (United States)

    Woon, D. E.; Park, J.-Y.

    2004-11-01

    The ethynyl radical (C2H) can attack unsaturated carbon-carbon bonds with no activation barrier, making such reactions very favorable under the low temperature and pressure conditions in Titan's upper atmosphere, where tholin production generates the satellite's distinctive haze layers. We have used density functional theory to characterize reactions between C2H and R1R2C=CR3R4 species ranging from ethylene to tetramethyl ethylene. Outcomes include multi-channel addition-elimination reactions and H abstraction. We will discuss trends in the reaction rates and product distributions as a function of temperature and pressure. Support for this work by the NASA Planetary Atmospheres program (grant NAG5-12305) is gratefully acknowledged.

  7. miR-144 functions as a tumor suppressor in breast cancer through inhibiting ZEB1/2-mediated epithelial mesenchymal transition process

    Directory of Open Access Journals (Sweden)

    Pan Y

    2016-10-01

    Full Text Available Yuliang Pan,1,2 Jun Zhang,1 Huiqun Fu,1 Liangfang Shen2 1Department of Oncology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China; 2Department of Oncology Radiotherapy, Xiangya Hospital of Central South University, Changsha, Hunan, People’s Republic of China Abstract: Breast cancer is the most common cancer in women worldwide. Local invasion, metastasis, and chemotherapy resistance are the obstacles for treatment of breast cancer. In this study, we aim to investigate the role of miR-144 in breast cancer. We demonstrate that the expression of miR-144 is downregulated in breast cancer and cell lines, and lower miR-144 expression is associated with poor differentiation, higher clinical stage, and lymph node metastasis in patients with breast cancer. The rescue of miR-144 expression is able to inhibit the cell proliferation and the ability of cell migration and invasion. In addition, we show that miR-144 can directly target at 3'-untranslation region of zinc finger E-box-binding homeobox 1 and 2, that is, ZEB1 and ZEB2, and regulate their expression at transcriptional and translational levels. Moreover, we also demonstrate that ectopic expression of miR-144 can inhibit the process of epithelial mesenchymal transition in MCF-7 and MDA-MB-231 cells. Thus, we here demonstrate that miR-144 functions as a tumor suppressor in breast cancer at least partly through inhibiting ZEB1/2-mediated epithelial mesenchymal transition process. Our findings indicate that the miR-144-ZEB1/2 signaling could represent a promising therapeutic target for breast cancer treatment. Keywords: breast cancer, miR-144, ZEB1, ZEB2, epithelial mesenchymal transition

  8. Theoretical uncertainty of (α ,n ) reactions relevant for the nucleosynthesis of light r -process nuclei in neutrino-driven winds

    Science.gov (United States)

    Pereira, J.; Montes, F.

    2016-03-01

    Background: Neutrino-driven winds following core-collapse supernova explosions have been proposed as a possible site where light r -process nuclei (between Fe and Ag) might be synthesized. In these events, (α ,n ) reactions are key to moving matter towards the region of higher proton number. Abundance network calculations are very sensitive to the rates for this type of reactions. Purpose: The present work aims at evaluating the theoretical uncertainty of these (α ,n ) reactions calculated with reaction codes based on the Hauser-Feshbach model. Method: We compared several (α ,n ) rates taken from talys and the non-smoker database to determine the uncertainties owing to the existing technical differences between both codes. In addition, we evaluated the sensitivity of talys rates to variations in the α optical potentials, masses, level densities, optical potentials, preequilibrium intranuclear transition rates, level structure, radiative transmission coefficients, and width-fluctuation correction factors. Results: The main source of uncertainty at low temperature is mostly attributable to the use of different α optical potentials. Differences between talys and non-smoker at high temperatures arise from the energy-binning algorithm used by each code. We have also noticed that the (α ,n ) rates from the non-smoker database correspond to the inclusive reaction, instead of the exclusive (α ,1 n ) channel calculated in the present work and used in network calculations. Conclusions: Theoretical uncertainties in calculated reaction rates can be as high as one to two orders of magnitude and strongly dependent on the temperature of the environment. Besides direct measurements of the inclusive and exclusive (α ,1 n ) reaction rates, experimental studies of α optical potentials are crucial to improve the performance of reaction codes.

  9. Processing and characterization of extruded PET and its r-PET and MWCNT nanocomposite thin films by spin coating

    Indian Academy of Sciences (India)

    Arvind R Singh; Vineeta D Deshpande

    2016-02-01

    The objective of the present study was basic understanding of the formation of thin film morphology by spin coating using reorganized polyethylene terephthalate (r-PET) and multiwalled carbon nanotubes (MWCNTs) as fillers in PET. A study of the correlation between physical properties of the PET films and its surface morphology was carried out using atomic force microscopy-based power spectral density (PSD) analysis. No significant work of surface analysis, using PSD of thin films of PET has been reported till date. Dilute solution of PET, PET with 3 wt% (r-PET) and PET with 3 wt% (2 wt% r-PET + 1 wt% MWCNT) filler were prepared using trifluoroacetic acid (TFA) as a solvent and thin films were fabricated on glass substrate by the optimized spin coating technique. Preparation of r-PET and r-PET+ MWCNT fillers was obtained by the precipitation method using TFA as a solvent and acetone as an antisolvent. The samples before spin coating were extruded and for comparison, a film of non-extruded PET was also prepared. Structural studies by Fourier transform infrared and X-ray diffraction show higher degree of crystallinity in r-PET and decrease in chain entanglements. Owing to the crystallizing behaviour of r-PET, it allows better dispersion of MWCNT in the polymer matrix as compared with PET. The samples with fillers of MWCNT show more compact and unique mesh-like globular structure, indicating application for electromagnetic shielding foams and fibres.

  10. Single nucleotide polymorphism in flanking region of miR-30c influences the maturing process of miR-30c in lung carcinoma%肺癌组织中miR-30c侧翼区的单核苷酸多态性对其成熟进程的影响

    Institute of Scientific and Technical Information of China (English)

    陈佳萍; 刘瑶; 胡志斌; 沈洪兵

    2012-01-01

    Objective To investigate the effect of a common polymorphism rs928508 (A/G) in flanking region of miR-30c on the expression of pri,pre and mature miR-30c,and discuss the effect of this polymorphism on the maturing process of miR-30c in lung carcinoma.Methods The pGL3-promoter-miR-30c-A and pGL3-promoter-miR-30c-G lueiferase plasmids were created containing A or G allele of miR-30c flanking region.Taqman assay was used to genotype rs928508 polymorphism in 50 lung cancer tissues.RTPCR was performed to determine the expression of pri-miR-30c,pre-miR-30c,mature miR-30c and miR-30c host gene NFYC in the 50 lung cancer tissues.Results The luciferase expression level of the pGL3-promoter-miR-30c-A construct group was not significantly different compared with that in the the pGL3-promoter-miR-30c-G construct group (A549 cells,P =0.758 ; 293A cells,P =0.554 ; CHO cells,P =0.175).The results demonstrated that rs928508 (A/G) variant had no effect on the transcriptional regulation of pri-miR-30c.In the genotype-phenotype collection analysis of the 50 lung cancer tissues,the expression of pre-miR-30c and mature miR-30c for rs928508 AG/GG genotypes showed significantly lower levels compared with those in the AA genotype (P =0.009,P =0.011).However,the expression of primiR-30c showed no significant difference between AG/GG genotypes and AA genotype.Similarly,the expression of host NFYC gene was correlated with pri-miR-30c,showed no significant difference between AG/GG genotypes and AA genotype.Conclusion The rs928508(A/G) polymorphism in flanking region of miR-30c could influence the processing from pri-miR-30c to mature miR-30c,but does not influence the transcription of pri-miR-30c.%目的 研究不同细胞和肺癌组织中miR-30c侧翼区单核苷酸多态性rs928508(A/G)对初级miR-30c(pri-miR-30c)、前体miR-30c(pre-miR-30c)、成熟miR-30c的表达水平以及miR-30c成熟进程的影响.方法 构建含有不同基因型miR-30c侧翼区的报告基因表达载体pGL3

  11. Age-related alterations of relaxation processes and non-Markov effects in stochastic dynamics of R-R intervals variability from human ECGs

    CERN Document Server

    Yulmetyev, R M; Panischev, O Y; Hänggi, P; Yulmetyev, Renat M.; Demin, Sergey A.; Panischev, Oleg Yu.; H\\"anggi, Peter

    2005-01-01

    In this paper we consider the age-related alterations of heart rate variability on the basis of the study of non-Markovian effects. The age dynamics of relaxation processes is quantitatively described by means of local relaxation parameters, calculated by the specific localization procedure. We offer a quantitative informational measure of non-Markovity to evaluate the change of statistical effects of memory. Local relaxation parameters for young and elderly people differ by 3.3 times, and quantitative measures of non-Markovity differ by 4.2 times. The comparison of quantitative parameters allows to draw conclusions about the reduction of relaxation rate with ageing and the higher degree of the Markovity of heart rate variability of elderly people.

  12. Logistiska verktyg för ökad konkurrenskraft : En fallstudie om hantering av interna processer och sortiment

    OpenAIRE

    Sundström, Sara; Vesterlund, Linnea

    2011-01-01

    Konkurrens och hur den påverkar företaget kan skilja sig beroende på bransch och vilket typ av marknad som företaget befinner sig på. Hur ett företag väljer att jobba med konkurrens och kampen om kunderna är en bidragande faktor till företagens resultat. Vidare är konkurrens något som bidrar till att driva utvecklingen framåt eftersom det uppmanar företagen till att sträva mot att ständigt ligga i framkant för att bli nummer ett i kundernas ögon. En bransch där kampen om kunderna har tilltagi...

  13. Examining the cross-cultural sensitivity of the Revised Two-Factor Study Process Questionnaire (R-SPQ-2F and validation of a Dutch version.

    Directory of Open Access Journals (Sweden)

    Ann Stes

    Full Text Available The Revised Two-Factor Study Process Questionnaire (R-SPQ-2F is used to examine students' study approaches in higher education. The questionnaire assumes to measure two factors: a deep and a surface study approach. Analyses into the validity and reliability of the original English R-SPQ-2F yielded positive results. In this study, we examined the degree to which these positive results can also be found for the Dutch version that we developed. By comparing our results with the results of earlier studies in different cultures, we conclude cross-cultural sensitivity is an important point to be borne in mind when using the R-SPQ-2F. Our research supports the validity and reliability of our Dutch version of the R-SPQ-2F.

  14. A High-Resolution Transmission-Type (TT) Phaser Based on Reflection-Type (RT) Units for Radio Analog Signal Processing (R-ASP)

    CERN Document Server

    Zou, Lianfeng

    2014-01-01

    A high Radio Analog Signal Processing (R-ASP) resolution transmission-type (TT) phaser based on reflection-type (RT) phaser units is introduced, theoretically studied and experimentally demonstrated. It is first shown that RT phasers inherently exhibit higher R-ASP resolution than their TT counterparts because their group delay swing is proportional to the reflection coefficient associated with a resonator coupling mechanism (admittance inverter), easy to maximize towards unity, rather than to a coupled-line coupling coefficient, typically restricted to values will inferior to unity, as in the RT case. Moreover, a detailed sensitivity analysis reveals that the proposed phaser is simultaneously features high R-ASP resolution and low sensitivity to fabrication tolerance, which makes it an ideal solution for R-ASP. The proposed phaser exhibits a 5 ns group delay swing over a fractional bandwidth of about 50% around 4 GHz.

  15. Inhibition of the processing of miR-25 by HIPK2-Phosphorylated-MeCP2 induces NOX4 in early diabetic nephropathy

    Science.gov (United States)

    Oh, Hyung Jung; Kato, Mitsuo; Deshpande, Supriya; Zhang, Erli; Sadhan, Das; Lanting, Linda; Wang, Mei; Natarajan, Rama

    2016-01-01

    Phosphorylated methyl-CpG binding protein2 (p-MeCP2) suppresses the processing of several microRNAs (miRNAs). Homeo-domain interacting protein kinase2 (HIPK2) phosphorylates MeCP2, a known transcriptional repressor. However, it is not known if MeCP2 and HIPK2 are involved in processing of miRNAs implicated in diabetic nephropathy. p-MeCP2 and HIPK2 levels were significantly increased, but Seven in Absentia Homolog1 (SIAH1), which mediates proteasomal degradation of HIPK2, was decreased in the glomeruli of streptozotocin injected diabetic mice. Among several miRNAs, miR-25 and its precursor were significantly decreased in diabetic mice, whereas primary miR-25 levels were significantly increased. NADPH oxidase4 (NOX4), a target of miR-25, was significantly increased in diabetic mice. Protein levels of p-MeCP2, HIPK2, and NOX4 were increased in high glucose (HG)- or TGF-β-treated mouse glomerular mesangial cells (MMCs). miR-25 (primary, precursor, and mature) and mRNA levels of genes indicated in the in vivo study showed similar trends of regulation in MMCs treated with HG or TGF-β. The HG- or TGF-β-induced upregulation of p-MeCP2, NOX4 and primary miR-25, but downregulation of precursor and mature miR-25, were attenuated by Hipk2 siRNA. These results demonstrate a novel role for the SIAH1/HIPK2/MeCP2 axis in suppressing miR-25 processing and thereby upregulating NOX4 in early diabetic nephropathy. PMID:27941951

  16. β decay of nuclei around 90Se: Search for signatures of a N=56 subshell closure relevant to the r process

    Science.gov (United States)

    Quinn, M.; Aprahamian, A.; Pereira, J.; Surman, R.; Arndt, O.; Baumann, T.; Becerril, A.; Elliot, T.; Estrade, A.; Galaviz, D.; Ginter, T.; Hausmann, M.; Hennrich, S.; Kessler, R.; Kratz, K.-L.; Lorusso, G.; Mantica, P. F.; Matos, M.; Montes, F.; Pfeiffer, B.; Portillo, M.; Schatz, H.; Schertz, F.; Schnorrenberger, L.; Smith, E.; Stolz, A.; Walters, W. B.; Wöhr, A.

    2012-03-01

    Background: Nuclear structure plays a significant role on the rapid neutron capture process (r process) since shapes evolve with the emergence of shells and subshells. There was some indication in neighboring nuclei that we might find examples of a new N=56 subshell, which may give rise to a doubly magic 3490Se56 nucleus.Purpose: β-decay half-lives of nuclei around 90Se have been measured to determine if this nucleus has in fact a doubly magic character.Method: The fragmentation of a 136Xe beam at the National Superconducting Cyclotron Laboratory at Michigan State University was used to create a cocktail of nuclei in the A=90 region.Results: We have measured the half-lives of 22 nuclei near the r-process path in the A=90 region. The half-lives of 88As and 90Se have been measured for the first time. The values were compared with theoretical predictions in the search for nuclear-deformation signatures of a N=56 subshell, and its possible role in the emergence of a potential doubly magic 90Se. The impact of such hypothesis on the synthesis of heavy nuclei, particularly in the production of Sr, Y, and Zr elements was investigated with a weak r-process network.Conclusions: The new half-lives agree with results obtained from a standard global QRPA model used in r-process calculations, indicating that 90Se has a quadrupole shape incompatible with a closed N=56 subshell in this region. The impact of the measured 90Se half-life in comparison with a former theoretical predication associated with a spherical half-life on the weak r process is shown to be strong.

  17. s-Process in Low Metallicity Stars. III. Individual analysis of CEMP-s and CEMP-s/r with AGB models

    CERN Document Server

    Bisterzo, S; Straniero, O; Cristallo, S; Kaeppeler, F

    2012-01-01

    We provide an individual analysis of 94 carbon enhanced metal-poor stars showing an s-process enrichment (CEMP-s) collected from the literature. The s-process enhancement observed in these stars is ascribed to mass transfer by stellar winds in a binary system from a more massive companion evolving faster toward the asymptotic giant branch (AGB) phase. The theoretical AGB nucleosynthesis models have been presented in Paper I. Several CEMP-s stars show an enhancement in both s and r-process elements (CEMP-s/r). In order to explain the peculiar abundances observed in CEMP-s/r stars, we assume that the molecular cloud from which CEMP-s formed was previously enriched in r-elements by Supernovae pollution. A general discussion and the method adopted in order to interpret the observations have been provided in Paper II. We present in this paper a detailed study of spectroscopic observations of individual stars. We consider all elements from carbon to bismuth, with particular attention to the three s-process peaks, l...

  18. The Revised Two-Factor Study Process Questionnaire (R-SPQ-2F): Exploratory and Confirmatory Factor Analyses at Item Level

    Science.gov (United States)

    Justicia, Fernando; Pichardo, M. Carmen; Cano, Francisco; Berben, A. B. G.; De la Fuente, Jesus

    2008-01-01

    The underlying structure of the Revised Two Factor version of the Study Process Questionnaire (R-SPQ-2F), a 20-item instrument for the evaluation of students' approaches to learning (SAL), was examined at item level using two independent groups of undergraduate students enrolled in the first (n = 314) and last (n = 522) years of their studies. The…

  19. The Revised Two-Factor Study Process Questionnaire (R-SPQ-2F): Exploratory and Confirmatory Factor Analyses at Item Level

    Science.gov (United States)

    Justicia, Fernando; Pichardo, M. Carmen; Cano, Francisco; Berben, A. B. G.; De la Fuente, Jesus

    2008-01-01

    The underlying structure of the Revised Two Factor version of the Study Process Questionnaire (R-SPQ-2F), a 20-item instrument for the evaluation of students' approaches to learning (SAL), was examined at item level using two independent groups of undergraduate students enrolled in the first (n = 314) and last (n = 522) years of their studies. The…

  20. Information processing and aspects of visual attention in children with the DSM-III-R diagnosis ''pervasive developmental disorder not otherwise specified'' (PDDNOS) .1. Focused and divided attention

    NARCIS (Netherlands)

    Althaus, M; deSonneville, LMJ; Minderaa, RB; Hensen, LGN; Til, RB

    1996-01-01

    A sample of 8-to 12-year-old nonhyperactive children of normal intelligence with the DSM-III-R diagnosis of pervasive developmental disorder not otherwise specified (PDDNOS) completed two selective attention tasks. Following a linear stage model of information processing, it was demonstrated that th

  1. Brazilian version of the Structured Interview for Disorders of Extreme Stress - Revised (SIDES-R: adaptation and validation process

    Directory of Open Access Journals (Sweden)

    Jessica Camargo

    2013-12-01

    Full Text Available BACKGROUND: Posttraumatic stress disorder (PTSD contemplates the impact of acute traumatic events, but the literature indicates that this is not true for chronic exposure to stress. In this sense, the category disorders of extreme stress not otherwise specified (DESNOS has been proposed to characterize the behavior and cognitive alterations derived from exposure to continuous early life stress. The Structured Interview for Disorders of Extreme Stress - Revised (SIDES-R was developed to investigate and measure DESNOS. Considering the lack of instruments designed to assess DESNOS, especially in Brazil, the aim of this study was to translate, adapt, and validate the contents of SIDES-R to Brazilian Portuguese (SIDES-R-BR. METHOD: The original interview was subjected to translation, back-translation, semantic equivalence and conceptual correspondence analyses by naive and specialized judges, respectively, an acceptability trial, and inter-rater validity analysis. RESULTS: The interview underwent semantic and structural adaptations considering the Brazilian culture. The final version, SIDES-R-BR, showed a mean understanding score of 4.98 on a 5-point verbal rating scale, in addition to a kappa coefficient of 0.853. CONCLUSION: SIDES-R-BR may be a useful tool in the investigation of DESNOS and contributes a valuable input to clinical research in Brazil. The availability of the instrument allows to test symptoms with adequate reliability, as verified by the kappa coefficient and translation steps.

  2. NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing

    Energy Technology Data Exchange (ETDEWEB)

    Yoshikatsu, Yuki [Department of Life Systems, Institute of Technology and Science, The University of Tokushima Graduate School, Tokushima 770-8506 (Japan); Ishida, Yo-ichi; Sudo, Haruka [Department of Molecular and Cellular Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588 (Japan); Yuasa, Keizo; Tsuji, Akihiko [Department of Life Systems, Institute of Technology and Science, The University of Tokushima Graduate School, Tokushima 770-8506 (Japan); Nagahama, Masami, E-mail: nagahama@my-pharm.ac.jp [Department of Molecular and Cellular Biochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588 (Japan)

    2015-08-28

    Nuclear VCP-like 2 (NVL2) is a member of the chaperone-like AAA-ATPase family and is involved in the biosynthesis of 60S ribosomal subunits in mammalian cells. We previously showed the interaction of NVL2 with a DExD/H-box RNA helicase MTR4/DOB1, which is a known cofactor for an exoribonuclease complex, the exosome. This finding implicated NVL2 in RNA metabolic processes during ribosome biogenesis. In the present study, we found that a series of mutations within the ATPase domain of NVL2 causes a defect in pre-rRNA processing into mature 28S and 5.8S rRNAs. Co-immunoprecipitation analysis showed that NVL2 was associated with the nuclear exosome complex, which includes RRP6 as a nucleus-specific catalytic subunit. This interaction was prevented by depleting either MTR4 or RRP6, indicating their essential role in mediating this interaction with NVL2. Additionally, knockdown of MPP6, another cofactor for the nuclear exosome, also prevented the interaction by causing MTR4 to dissociate from the nuclear exosome. These results suggest that NVL2 is involved in pre-rRNA processing by associating with the nuclear exosome complex and that MPP6 is required for maintaining the integrity of this rRNA processing complex. - Highlights: • ATPase-deficient mutants of NVL2 have decreased pre-rRNA processing. • NVL2 associates with the nuclear exosome through interactions with MTR4 and RRP6. • MPP6 stabilizes MTR4-RRP6 interaction and allows NVL2 to interact with the complex.

  3. miR-181b as a key regulator of the oncogenic process and its clinical implications in cancer (Review).

    Science.gov (United States)

    Liu, Juan; Shi, Weifeng; Wu, Changping; Ju, Jingfang; Jiang, Jingting

    2014-01-01

    MicroRNAs (miRNAs or miRs) are small, non-coding, single-stranded RNA molecules that regulate gene expression at the post-transcriptional level to repress protein expression of target genes. Among these, miR-181b has been found to be a critical regulatory miRNA linking inflammation and cancer. The functional significance of miR-181b in various tumors and translational research suggests that it exhibits great potential as a predictive and prognostic biomarker. Extensive efforts are underway to identify mRNA targets and the affected regulatory networks, which may be the key to providing a better understanding of miR-181b-mediated signaling pathways.

  4. Nop9 is a PUF-like protein that prevents premature cleavage to correctly process pre-18S rRNA

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Jun; McCann, Kathleen L.; Qiu, Chen; Gonzalez, Lauren E.; Baserga, Susan J.; Hall, Traci M. Tanaka

    2016-10-11

    Numerous factors direct eukaryotic ribosome biogenesis, and defects in a single ribosome assembly factor may be lethal or produce tissue-specific human ribosomopathies. Pre-ribosomal RNAs (pre-rRNAs) must be processed stepwise and at the correct subcellular locations to produce the mature rRNAs. Nop9 is a conserved small ribosomal subunit biogenesis factor, essential in yeast. Here we report a 2.1-Å crystal structure of Nop9 and a small-angle X-ray-scattering model of a Nop9:RNA complex that reveals a ‘C’-shaped fold formed from 11 Pumilio repeats. We show that Nop9 recognizes sequence and structural features of the 20S pre-rRNA near the cleavage site of the nuclease, Nob1. We further demonstrate that Nop9 inhibits Nob1 cleavage, the final processing step to produce mature small ribosomal subunit 18S rRNA. Together, our results suggest that Nop9 is critical for timely cleavage of the 20S pre-rRNA. Moreover, the Nop9 structure exemplifies a new class of Pumilio repeat proteins.

  5. Nop9 is a PUF-like protein that prevents premature cleavage to correctly process pre-18S rRNA

    Science.gov (United States)

    Zhang, Jun; McCann, Kathleen L.; Qiu, Chen; Gonzalez, Lauren E.; Baserga, Susan J.; Hall, Traci M. Tanaka

    2016-01-01

    Numerous factors direct eukaryotic ribosome biogenesis, and defects in a single ribosome assembly factor may be lethal or produce tissue-specific human ribosomopathies. Pre-ribosomal RNAs (pre-rRNAs) must be processed stepwise and at the correct subcellular locations to produce the mature rRNAs. Nop9 is a conserved small ribosomal subunit biogenesis factor, essential in yeast. Here we report a 2.1-Å crystal structure of Nop9 and a small-angle X-ray-scattering model of a Nop9:RNA complex that reveals a ‘C'-shaped fold formed from 11 Pumilio repeats. We show that Nop9 recognizes sequence and structural features of the 20S pre-rRNA near the cleavage site of the nuclease, Nob1. We further demonstrate that Nop9 inhibits Nob1 cleavage, the final processing step to produce mature small ribosomal subunit 18S rRNA. Together, our results suggest that Nop9 is critical for timely cleavage of the 20S pre-rRNA. Moreover, the Nop9 structure exemplifies a new class of Pumilio repeat proteins. PMID:27725644

  6. Over-expression of miR-106b promotes cell migration and metastasis in hepatocellular carcinoma by activating epithelial-mesenchymal transition process.

    Directory of Open Access Journals (Sweden)

    Wing Lung Yau

    Full Text Available Hepatocellular carcinoma (HCC is one the the most fatal cancers worldwide. The poor prognosis of HCC is mainly due to the developement of distance metastasis. To investigate the mechanism of metastasis in HCC, an orthotopic HCC metastasis animal model was established. Two sets of primary liver tumor cell lines and corresponding lung metastasis cell lines were generated. In vitro functional analysis demonstrated that the metastatic cell line had higher invasion and migration ability when compared with the primary liver tumor cell line. These cell lines were subjected to microRNA (miRNAs microarray analysis to identify differentially expressed miRNAs which were associated with the developement of metastasis in vivo. Fifteen human miRNAs, including miR-106b, were differentially expressed in 2 metastatic cell lines compared with the primary tumor cell lines. The clinical significance of miR-106b in 99 HCC clinical samples was studied. The results demonstrated that miR-106b was over-expressed in HCC tumor tissue compared with adjacent non-tumor tissue (p = 0.0005, and overexpression of miR-106b was signficantly correlated with higher tumor grade (p = 0.018. Further functional studies demonstrated that miR-106b could promote cell migration and stress fiber formation by over-expressing RhoGTPases, RhoA and RhoC. In vivo functional studies also showed that over-expression of miR-106b promoted HCC metastasis. These effects were related to the activation of the epithelial-mesenchymal transition (EMT process. Our results suggested that miR-106b expression contributed to HCC metastasis by activating the EMT process promoting cell migration in vitro and metastasis in vivo.

  7. The role of the prefrontal cortex in familiarity and recollection processes during verbal and non-verbal recognition memory: an rTMS study.

    Science.gov (United States)

    Turriziani, Patrizia; Smirni, Daniela; Oliveri, Massimiliano; Semenza, Carlo; Cipolotti, Lisa

    2010-08-01

    Neuroimaging and lesion studies have documented the involvement of the frontal lobes in recognition memory. However, the precise nature of prefrontal contributions to verbal and non-verbal memory and to familiarity and recollection processes remains unclear. The aim of the current rTMS study was to investigate for the first time the role of the DLPFC in encoding and retrieval of non-verbal and verbal memoranda and its contribution to recollection and familiarity processes. Recollection and familiarity processes were studied using the ROC and unequal variance signal detection methodologies. We found that rTMS delivered over left and right DLPFC at encoding resulted in material specific laterality effects with a disruption of recognition of verbal and non-verbal memoranda. Interestingly, rTMS over DLPFCs at encoding significantly affected both recollection and familiarity. However, at retrieval rTMS did not affect recollection and familiarity. Our results suggest that DLPFC has a degree of functional specialisation and plays an important role in the encoding of verbal and non-verbal memoranda.

  8. Exploring the Interrelationship of Structure and Process in Family Child Care: The FCCERS-R and "Combined" CLASS

    Science.gov (United States)

    Enns, Lionel

    2012-01-01

    This study examined the correlations between two prominent family child care environmental rating scales, the Family Child Care Environment Rating Scale - Revised (FCCERS-R) and the "Combined" Classroom Assessment Scoring System ("Combined" CLASS), both of which were used during the pilot study of Washington State's Quality…

  9. ACToR Chemical Structure processing using Open Source ChemInformatics Libraries (FutureToxII)

    Science.gov (United States)

    ACToR (Aggregated Computational Toxicology Resource) is a centralized database repository developed by the National Center for Computational Toxicology (NCCT) at the U.S. Environmental Protection Agency (EPA). Free and open source tools were used to compile toxicity data from ove...

  10. An autoregulatory network between menin and pri-miR-24-1 is required for the processing of its specific modulator miR-24-1 in BON1 cells.

    Science.gov (United States)

    Luzi, Ettore; Marini, Francesca; Ciuffi, Simone; Galli, Gianna; Brandi, Maria Luisa

    2016-05-24

    Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary cancer complex syndrome manifesting a variety of endocrine and non-endocrine neoplasms and lesions. MEN1 is characterized by tumours of the parathyroids, of the neuroendocrine cells of the gastroenteropancreatic tract, and of the anterior pituitary. The MEN1 gene, a tumour suppressor gene, encodes the menin protein. Loss of heterozygosity (LOH) at 11q13 is typical of MEN1 tumours in agreement with Knudson's two-hit hypothesis. We previously showed that the MEN1 parathyroid tumorigenesis is under the control of an "incoherent feedback loop" between miR-24-1 and the menin protein that generates a "Gene Regulatory Network" (GRN) that mimics the second hit of Knudson's hypothesis and that could buffer the effect of the stochastic factors that contribute to the onset and progression of this disease. Here we show, in the BON1 cell line derived from lymphnode metastasis of a human carcinoid tumour of the pancreas, that menin binds specifically to the primary RNA sequence pri-miR-24-1 by promoting the miR-24-1 biogenesis. Network simulation showed a new feed-forward loop between menin, microRNA-24-1 and Musashi-1 proteins. This result shows a novel mechanism whereby menin, a RNA-binding protein, facilitates the processing of its specific miRNA by regulating the dynamics of the menin-miR-24 Gene Regulatory Network at the level of pri-miRNA processing.

  11. The Role of R&D and Innovation in Regional Development: An Interregional Analysis with DEMATEL-Based Analytic Network Process (DANP and TOPSIS Methods

    Directory of Open Access Journals (Sweden)

    Enver Çakın

    2015-06-01

    Full Text Available R&D, innovation and information-based activities has become more important in recent years for regional development and elimination of regional development differences. Countries have also recognized that innovation is the most important factor of economic growth and begun to allocate more resource to R&D investments. In this study, for years of 2010, 2011 and 2012 the innovation performance of 12 regions sited at first level of Nomenclature of Units for Territorial Statistics (NUTS in Turkey, have been evaluated by taking basic R&D and innovation indicators into consideration. In this context regression analysis, DEMATEL-Based Analytic Network Process (DANP and TOPSIS methods have been applied. The criteria have been weighted by using the regression coefficients obtained through regression analysis in DEMATEL method and subsequently performance ranking of regions has been performed by TOPSIS method.

  12. {sup 13,14}B(n, γ) via Coulomb Dissociation for Nucleosynthesis towards the r-Process

    Energy Technology Data Exchange (ETDEWEB)

    Altstadt, S.G., E-mail: s.altstadt@gsi.de [Goethe-Universität Frankfurt am Main, D-60438 Frankfurt am Main (Germany); GSI Helmholtzzentrum für Schwerionenforschung, D-64291 Darmstadt (Germany); Adachi, T. [KVI, University of Groningen, Zernikelaan 25, NL-9747 AA Groningen (Netherlands); Aksyutina, Y. [GSI Helmholtzzentrum für Schwerionenforschung, D-64291 Darmstadt (Germany); ExtreMe Matter Institute EMMI, GSI Helmholtzzentrum für Schwerionenforschung GmbH, 64291 Darmstadt (Germany); Alcantara, J.; Alvarez-Pol, H. [Departamento de Física de Partículas, Universidade de Santiago de Compostela, 15706 Santiago de Compostela (Spain); Ashwood, N. [School of Physics and Astronomy, University of Birmingham, Birmingham B15 2TT (United Kingdom); Atar, L. [Institut für Kernphysik, Technische Universität Darmstadt, D-64289 Darmstadt (Germany); Aumann, T. [Institut für Kernphysik, Technische Universität Darmstadt, D-64289 Darmstadt (Germany); GSI Helmholtzzentrum für Schwerionenforschung, D-64291 Darmstadt (Germany); Avdeichikov, V. [Department of Physics, Lund University, S-22100 Lund (Sweden); Barr, M. [School of Physics and Astronomy, University of Birmingham, Birmingham B15 2TT (United Kingdom); Beceiro, S. [Departamento de Física de Partículas, Universidade de Santiago de Compostela, 15706 Santiago de Compostela (Spain); Bemmerer, D. [Helmholtz-Zentrum Dresden-Rossendorf, D-01328 Dresden (Germany); and others

    2014-06-15

    Radioactive beams of {sup 14,15}B produced by fragmentation of a primary {sup 40}Ar beam were directed onto a Pb target to investigate the neutron breakup within the Coulomb field. The experiment was performed at the LAND/R{sup 3}B setup. Preliminary results for the Coulomb dissociation cross sections as well as for the astrophysically interesting inverse reactions, {sup 13,14}B(n,γ), are presented.

  13. The R and M 2000 Process and Reliability and Maintainability Management: Attitudes of Senior Level Managers in Aeronautical Systems Division

    Science.gov (United States)

    1988-09-01

    maintain an Air Force Center of Excellence for Reliability and Maintainability ( CERM ). The Center’s charter is to develop R&M concepts, theory, and...AFIT’s role as the Air Force’s CERM and since ASD is located at Wright-Patterson along with AFIT, it seemed the natural choice for keeping the scope of...Integrity Program BCM Baseline Correlation Matrix CDR Critical Design Review CDS [F-16] Central Data System CERM Center of Excellence for Reliability

  14. Planejamento econômico de gráficos Xbarra e R para processos regenerativos e não regenerativos Economic designs of Xbarra-R charts for regenerative and non-regenerative process

    Directory of Open Access Journals (Sweden)

    Osiris Turnes

    2004-04-01

    Full Text Available Neste estudo é realizada uma comparação entre dois modelos de planejamento econômico de gráficos de controle Xbarra-R. O primeiro modelo propõe que a distribuição do tempo em que o processo se mantém sob controle tem por propriedade a falta de memória; este modelo é apropriado para modelar processos não regenerativos. No segundo modelo, esta propriedade não é mais válida, sendo adequada para processos regenerativos.A comparison of two economic designs of Xbarra-R charts is made in this study. The first model assumes that the distribution of the time that the process remains under statistical control has the lack of memory property. This model is appropriate to model non-regenerative process. In the second model, the property of lack of memory does not hold being more appropriate to describe regenerative process.

  15. Footprints of a trypanosomatid RNA world: pre-small subunit rRNA processing by spliced leader addition trans-splicing

    Directory of Open Access Journals (Sweden)

    Mario Gustavo Mayer

    2012-06-01

    Full Text Available The addition of a capped mini-exon [spliced leader (SL] through trans-splicing is essential for the maturation of RNA polymerase (pol II-transcribed polycistronic pre-mRNAs in all members of the Trypanosomatidae family. This process is an inter-molecular splicing reaction that follows the same basic rules of cis-splicing reactions. In this study, we demonstrated that mini-exons were added to precursor ribosomal RNA (pre-rRNA are transcribed by RNA pol I, including the 5' external transcribed spacer (ETS region. Additionally, we detected the SL-5'ETS molecule using three distinct methods and located the acceptor site between two known 5'ETS rRNA processing sites (A' and A1 in four different trypanosomatids. Moreover, we detected a polyadenylated 5'ETS upstream of the trans-splicing acceptor site, which also occurs in pre-mRNA trans-splicing. After treatment with an indirect trans-splicing inhibitor (sinefungin, we observed SL-5'ETS decay. However, treatment with 5-fluorouracil (a precursor of RNA synthesis that inhibits the degradation of pre-rRNA led to the accumulation of SL-5'ETS, suggesting that the molecule may play a role in rRNA degradation. The detection of trans-splicing in these molecules may indicate broad RNA-joining properties, regardless of the polymerase used for transcription.

  16. Report on the results of the fiscal 1997 R and D under consignment from NEDO of photon measuring/processing technology (R and D of petroleum production system high-grade measuring/processing technology); 1997 nendo Shin energy Sangyo Gijutsu Sogo Kaihatsu Kiko itaku photon keisoku kako gijutsu (sekiyu seisan system kodo keisoku kako gijutsu kenkyu kaihatsu) seika hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    The R and D were conducted of high-strength and high-accuracy welding/joining technology using laser, technology to measure and assess the joining state of structures and defects around the surface of structures and inside structures by high accuracy and high resolution, and technology/equipment to generate a laser light source for the tool, which are all required to remarkably enhance safety/reliability of oil drilling facilities working in the severe environment. In fiscal 1997, as the R and D of oil production system high-grade measuring/processing technology, technical study, study of measures to be taken, operating experiment, assessment, examination, etc. were conducted on the following themes: 1) macroscopic processing technology (R and D of high-reliability laser welding technology), 2) non-destructive composition measuring technology (R and D of internal measurement and photoelectron spectroscopy using short-wavelength radiation), 3) tight-focusing all-solid-state laser technology (R and D of fiber laser), 4) tight-focusing all-solid-state laser technology (R and D of high-efficiency laser diode), and 5) comprehensive investigation of phonics engineering (investigation for photon-applied materials processing technology). 256 refs., 205 figs., 18 tabs.

  17. Numerical simulation of formation process of transformed zone and R-curve behavior in partially stabilized zirconia. Bubun anteika zirconia no hentai ryoiki keisei katei to R kyokusen kyodo no suchi simulation

    Energy Technology Data Exchange (ETDEWEB)

    Kageyama, K.; Enoki, M.; Kishi, T. (The University of Tokyo, Tokyo (Japan). Research Center for Advanced Science and Technology)

    1992-07-20

    The toughening mechanism by stress-induced transformation in partially stabilized zirconia has been proposed by McMeeking,et al. However, their model is not coincident with the experimental data on Ce-TZP by Yu, et al., because it is assumed that the transformation volume fraction of the former model is low and the stress field is formed only at the main crack tip. In this paper, it is considered that the stress field is formed not only at the main crack tip but also by transformed particles with expanded volume. Consequently, numerical simulation of the shape and width of the transformed zone and R-curve behavior in partially stabilized zirconia was carried out. As a result of analyses, the formation process of the transformed zone was divided into two types due to transformation volume fractions. In the case of the low transformation volume fraction, the R-curve behavior agrees with the analysis by McMeeking et al., and the width of the transformed zone does not change even with crack extension. In the case of the high fraction, however, change in the shape and extension of the width of the transformed zone occur discontinuously along the crack extension. It shows a step-like R-curve behavior. 10 refs., 10 figs.

  18. Research Analysis of RtR Control Method for Lithography Process%光刻过程RtR控制方法研究进展分析

    Institute of Scientific and Technical Information of China (English)

    王亮; 胡静涛

    2011-01-01

    Firstly, the lithography process and background of RtR control technique were introduced.The shortage of statistical process control was analyzed and the general structure of the RtR controller was given. Then, an overview and evaluation about EWMA, MPC and ANN controllers of the lithography process were given in the ways of modeling and control algorithms. Besides, the comparative analysis of the nonlinear control, SISO control, MISO control, MIMO control and optimization control quality of three controllers were presented. Finally, it is proposed that the multivariable nonlinear controllers based on MPC become the future development direction of the lithography process RtR controller.%首先对光刻过程和RtR (Run-to-Run)控制技术的产生背景进行了介绍,对统计过程控制的不足进行了分析并给出了RtR控制器的一般结构.然后从过程建模和控制算法两个角度对三种主要的光刻过程RtR控制器EWMA,MPC和ANN进行了综述和评价,对这三种控制器在非线性控制、单变量控制、多变童控制的适用性和优化控制效果进行了比较分析.最后指出基于MPC的非线性多变量控制器将成为光刻过程RtR控制器的主要研究方向.

  19. An end-to-end system in support of a broad scope of GOES-R sensor and data processing study

    Science.gov (United States)

    Huang, Hung-Lung

    2005-08-01

    The mission of NOAA's Geostationary Operational Environmental Satellite System (GOES) R series satellites, in the 2012 time frame, is to provide continuous, near real-time meteorological, oceanographic, solar, and space environment data that supports NOAA's strategic mission goals. It presents an exciting opportunity to explore new instruments, satellite designs, and system architectures utilizing new communication and instrument technologies in order to meet the ever-increasing demands made of Earth observation systems by national agencies and end users alike. The GOES-R sensor suite includes a 16 spectral band Advanced Baseline Imager (ABI), an approximately 1500 high spectral resolution band Hyperspectral Environmental Suite (HES), plus other sensors designed to detect lightning and to explore the ocean, solar and space environment. The Cooperative Institute for Meteorological Satellite Studies (CIMSS) as part of the Space Science and Engineering Center (SSEC) of the University of Wisconsin-Madison, the long time partner of NOAA, has developed the first operational end-to-end processing system for GOES. Based on this heritage, and with recent support from the NASA/NOAA Geosynchrous Imaging FTS (GIFTS) project, the Navy's Multiple University Research Initiative (MURI), and NOAA's GOES-R Risk Reduction program, SSEC has built a near-complete end-to-end system that is capable of simulating sensor measurements from top of atmosphere radiances, raw sensor data (level 0) through calibrated and navigated sensor physical measurements (level 1) to the processed products (level 2). In this paper, the SSEC Hyperspectral Imaging and Sounding Simulator and Processor (HISSP) will be presented in detail. HISSP is capable of demonstrating most of the processing functions such as data compression/decompression, sensor calibration, data processing, algorithm development, and product generation. In summary, HISSP is an end-to-end system designed to support both government and

  20. SOME ASPECTS OF POLITICAL PROCESS RЕBIYA KADЕЕR AS ONE OF UYGHUR NATIONAL MOVEMENT LEADERS

    Directory of Open Access Journals (Sweden)

    D. V. Buyarov

    2015-01-01

    Full Text Available In article some facts of the biography of the famous Uygur politician and participant of the dissident movement – to Rеbiya Кadeer who in the late nineties took active part in a human rights movement in the conditions of tough national policy of the central government of the People's Republic of China in Xinjiang Uyghur autonomous region which is one of the most restless regions of the People's Republic of China are considered. It is caused by that SUAR being the area of traditional accommodation of Uyghurs is exposed to the strengthened khanization. In the 2000th R. Кadeer enters political struggle on protection of the national rights of the Uygur population in Xinjiang and becomes the leader of the international Uygur movement, drawing to this problem attention of public opinion. Rabiya Кadeer was condemned for the political activity by the Chinese court and some years spent in prison that made it even more known. Are presented in article and various estimates of a political figure of River are compared. Кadeer who the Chinese authorities is called the head of the Uygur terrorists and separatists, and most of Uyghurs and the government of a number of the states, consider the informal leader of the Uygur people striving for national independence. Today, as the president of the World Uygur congress R. Кadeer supports national self-determination of the Uygur ethnos, without calling thus for separatism and condemning manifestations of national extremism. Кadeer also, as well as many other leaders of the Uygur national movement supports peace methods of fight and condemns terrorism. When writing article, along with domestic researches on national policy of China, the English-speaking sources presented by materials of biographic character, news publications and interview to R. Кadeer were used.

  1. INTELLECTUAL PROPERTY RISK CONTROL IN R & D PROCESS%研发过程中知识产权风险的控制

    Institute of Scientific and Technical Information of China (English)

    魏众; 穆静静; 朱红玉

    2012-01-01

    Corporate intellectual property includes trademarks, patents and copyrights, etc. , all of which are important intangible assets of enterprises. At present, most enterprises havent paid enough attention to corpo- rate intellectual property protection, especially patent protection and failed to apply for patents in time and comprehensively in the R & D process, which exposes the enterprises to significant risks in the whole process from project R & D to market occupation. This article offers thoughts on measures of preventing relevant risk during the R & D process from the perspective of intellectual property protection.%企业知识产权包括商标、专利和著作权等,它是企业重要的无形资产。目前,国内大多数企业还不够重视企业的知识产权保护,尤其是专利保护。在研发过程中的专利申请及保护不及时、不到位,导致企业从项目研发到市场占有的整个过程蒙受巨大风险。从知识产权保护角度,探讨了企业研发过程中有关风险的防范措施。

  2. The nuclear physics input to astrophysics modelling, and the r- and p-processes: Where do we stand 50 years after B^2FH and Cameron?

    Science.gov (United States)

    Arnould, M.

    2008-11-01

    This is a brief review of the progress made since the seminal contributions to the foundations of the theory of nucleosynthesis by M. Burbidge, G. Burbidge, Fowler and Hoyle, and by Cameron. The reviewed topics are (1) the nuclear physics input to the nucleosynthesis models (nuclear masses, fission, rates of β-decays, neutrino reactions, photoreactions, and nuclear charged particle-induced or neutron-induced reactions), (2) the nuclear physics and astrophysics aspects of the r-process, and (3) the same items for the p-process.

  3. 三七皂苷 R1壳聚糖纳米粒的制备及其工艺优化%Preparation and process optimization of notoginsenoside R1 chitosan nanoparticles

    Institute of Scientific and Technical Information of China (English)

    虞璐; 魏宇峰

    2016-01-01

    /mL.The intra day precision were 1.520%,0.884% and 0.969%(n =6),and the inter day precision were 1.591%,1.447% and 1.269%(n =6).The recovery rates of low,medium and high concentra-tions were (98.11 ±1.16)%,(101.27 ±0.59)% and (100.97 ±0.82)%.4 factors of orthogonal experiment:the concentration of chitosan,the mass ratio of drug and carrier,temperature and rotational speed,and 3 levels of each factor were selected.The average particle size,encapsulation efficiency and drug loading were selected as control indexes.The test results were determined by the method of comprehensive weighted scoring.The orthogonal design was designed according to L9(34)orthogonal design.The optimization process was 2% of chitosan concentration,20% of the weight ratio of drug and carrier,35 ℃ of temperature,600 r/min of rotational speed.According to the optimized process,the average particle size was (123.40 ±7.68)nm,the encapsulation efficiency was (58.41 ±1.59)%,and the drug loading amount was (10.46 ±0.53)%.Conclusion The optimized preparation process of notoginsenoside R1 chitosan nanoparticles is simple and easy to operate,the entrapment efficiency and drug loading amount were high. As a new dosage form,it has a good clinical application prospect.

  4. Novel Magnetically Fluidized Bed Reactor Development for the Looping Process: Coal to Hydrogen Production R&D

    Energy Technology Data Exchange (ETDEWEB)

    Mei, Renwei; Hahn, David; Klausner, James; Petrasch, Jorg; Mehdizadeh, Ayyoub; Allen, Kyle; Rahmatian, Nima; Stehle, Richard; Bobek, Mike; Al-Raqom, Fotouh; Greek, Ben; Li, Like; Chen, Chen; Singh, Abhishek; Takagi, Midori; Barde, Amey; Nili, Saman

    2013-09-30

    The coal to hydrogen project utilizes the iron/iron oxide looping process to produce high purity hydrogen. The input energy for the process is provided by syngas coming from gasification process of coal. The reaction pathways for this process have been studied and favorable conditions for energy efficient operation have been identified. The Magnetically Stabilized Porous Structure (MSPS) is invented. It is fabricated from iron and silica particles and its repeatable high performance has been demonstrated through many experiments under various conditions in thermogravimetric analyzer, a lab-scale reactor, and a large scale reactor. The chemical reaction kinetics for both oxidation and reduction steps has been investigated thoroughly inside MSPS as well as on the surface of very smooth iron rod. Hydrogen, CO, and syngas have been tested individually as the reducing agent in reduction step and their performance is compared. Syngas is found to be the most pragmatic reducing agent for the two-step water splitting process. The transport properties of MSPS including porosity, permeability, and effective thermal conductivity are determined based on high resolution 3D CT x-ray images obtained at Argonne National Laboratory and pore-level simulations using a lattice Boltzmann Equation (LBE)-based mesoscopic model developed during this investigation. The results of those measurements and simulations provide necessary inputs to the development of a reliable volume-averaging-based continuum model that is used to simulate the dynamics of the redox process in MSPS. Extensive efforts have been devoted to simulate the redox process in MSPS by developing a continuum model consist of various modules for conductive and radiative heat transfer, fluid flow, species transport, and reaction kinetics. Both the Lagrangian and Eulerian approaches for species transport of chemically reacting flow in porous media have been investigated and verified numerically. Both approaches lead to correct

  5. Takagi-Sugeno model based analysis of EWMA RtR control of batch processes with stochastic metrology delay and mixed products.

    Science.gov (United States)

    Zheng, Ying; Wong, David Shan-Hill; Wang, Yan-Wei; Fang, Huajing

    2014-07-01

    In many batch-based industrial manufacturing processes, feedback run-to-run control is used to improve production quality. However, measurements may be expensive and cannot always be performed online. Thus, the measurement delay always exists. The metrology delay will affect the stability and performance of the process. Moreover, since quality measurements are performed offline, delay is not fixed but is stochastic in nature. In this paper, a modeling approach Takagi-Sugeno (T-S) model is presented to handle stochastic metrology delay in both single-product and mixed-product processes. Based on the Markov characteristics of the delay, the membership of the T-S model is derived. Performance indices such as the mean and the variance of the closed-loop output of the exponentially weighted moving average (EWMA) control algorithm can be derived. A steady-state error of the process output always exists, which leads the output deviating from the target. To remove the steady-state error, an algorithm called compensatory EWMA run-to-run (COM-EWMA-RtR) algorithm is proposed. The validity of the T-S model analysis and the efficiency of the proposed COM-EWMA-RtR algorithm are confirmed by simulation.

  6. The role of binaries in the enrichment of the early Galactic halo. I. r-process-enhanced metal-poor stars

    CERN Document Server

    Hansen, T T; Nordstrøm, B; Beers, T C; Yoon, J; Buchhave, L A

    2015-01-01

    The detailed chemical composition of most metal-poor halo stars has been found to be highly uniform, but a minority of stars exhibit dramatic enhancements in their abundances of heavy neutron-capture elements and/or of carbon. The key question for Galactic chemical evolution models is whether these peculiarities reflect the composition of the natal clouds, or if they are due to later mass transfer of processed material from a binary companion. If the former case applies, the observed excess of certain elements was implanted within selected clouds in the early ISM from a production site at interstellar distances. Our aim is to determine the frequency and orbital properties of binaries among these chemically peculiar stars. This information provides the basis for deciding whether mass transfer from a binary companion is necessary and sufficient to explain their unusual compositions. This paper discusses our study of a sample of 17 moderately (r-I) and highly (r-II) r-process-element enhanced VMP and EMP stars. ...

  7. Identification of a 67 kDa protein that binds specifically to the pre-rRNA primary processing site in a higher plant.

    Science.gov (United States)

    Echeverria, M; Lahmy, S

    1995-01-01

    In radish pre-rRNA primary processing cleavage occurs at a UUUUCGCGC element (motif P) mapped in the 5'-external transcribed spacer (Delcasso-Tremousaygue et al., 1988). Significantly, motif P is part of a cluster of homologous elements including three UUUUCCGG elements (motifs A123) and a single UUUUGCCCC element (motif B). Here we used the EMSA to identify in radish extracts an RNA-binding activity, NF C, that specifically interacts with the pre-rRNA A123BP sequence. Using different RNA probes and competitors we show that NF C recognises a 38 base RNA sequence including the 3'-end of motif A3 and motifs B and P. NF C binds to poly U, but not to poly A, poly C or poly G. Therefore we used poly (U) Sepharose chromatography as a final step to obtain pure NF C fractions. These, analysed by SDS-PAGE, revealed two major polypeptides of 67 and 60 kDa. According to UV cross-linking analysis the 67 kDa polypeptide corresponds to NF C activity, while the 60 kDa species is a proteolysed form of this protein. We also showed that NF C is enriched in nuclear extracts. Based on its stringent RNA substrate specificity and its nuclear localisation we propose that NF C is involved in pre-rRNA primary processing in plants. Images PMID:8559652

  8. A note on optimal (s,S) and (R,nQ) policies under a stuttering Poisson demand process

    DEFF Research Database (Denmark)

    Larsen, Christian

    2015-01-01

    In this note, a new efficient algorithm is proposed to find an optimal (s, S) replenishment policy for inventory systems with continuous reviews and where the demand follows a stuttering Poisson process (the compound element is geometrically distributed). We also derive three upper bounds...

  9. A note on optimal (s,S) and (R,nQ) policies under a stuttering Poisson demand process

    DEFF Research Database (Denmark)

    Larsen, Christian

    2015-01-01

    In this note, a new efficient algorithm is proposed to find an optimal (s, S) replenishment policy for inventory systems with continuous reviews and where the demand follows a stuttering Poisson process (the compound element is geometrically distributed). We also derive three upper bounds for the...

  10. INVESTIGATION OF AQUEOUS BIPHASIC SYSTEMS FOR THE SEPARATIONS OF LIGNINS FROM CELLULOSE IN THE PAPER PULPING PROCESS. (R826732)

    Science.gov (United States)

    In efforts to apply a polymer-based aqueous biphasic system (ABS) extraction to the paper pulping process, the study of the distribution of various lignin and cellulosic fractions in ABS and the effects of temperature on system composition and solute partitioning have been inv...

  11. NATO/CCMS PILOT STUDY CLEAN PRODUCTS AND PROCESSES (PHASE 1) 1998 ANNUAL REPORT (EPA/600/R-98/065)

    Science.gov (United States)

    This annual report presents the proceedings of the first annual NATO/CCMS pilot study meeting in Cincinnati in March 1998. Guest speakers focused on efforts in the research arena of clean products, clean processes, life cycle analysis, ecolabeling, and pollution prevention tools.

  12. Magnetocaloric effect of RM2 (R = rare earth, M = Ni, Al) intermetallic compounds made by centrifugal atomization process for magnetic refrigerator

    Science.gov (United States)

    Matsumoto, K.; Asamato, K.; Nishimura, Y.; Zhu, Y.; Abe, S.; Numazawa, T.

    2012-12-01

    RM2 (R = rare earth, M = Al, Ni and Co) compounds have large entropy change and magnetic transition temperatures can be controlled by change of R and/or M so that are suitable to a magnetic refrigerator for hydrogen liquefaction under development. In order to improve refrigerator performance, spherical powdered HoAl2, DyAl2, and GdNi2 compounds with submillimeter diameter were synthesized by centrifugal atomization process. By measuring the magnetization and heat capacity, we obtained entropy change by magnetic fields and entropy as functions of temperature and magnetic field, which are essential for analysing the magnetic refrigeration cycle. All samples showed sharp magnetic transitions and had good potentials for use in magnetic refrigeration.

  13. Development of a prototype chest digital tomosynthesis (CDT) R/F system with fast image reconstruction using graphics processing unit (GPU) programming

    Science.gov (United States)

    Choi, Sunghoon; Lee, Seungwan; Lee, Haenghwa; Lee, Donghoon; Choi, Seungyeon; Shin, Jungwook; Seo, Chang-Woo; Kim, Hee-Joung

    2017-03-01

    Digital tomosynthesis offers the advantage of low radiation doses compared to conventional computed tomography (CT) by utilizing small numbers of projections ( 80) acquired over a limited angular range. It produces 3D volumetric data, although there are artifacts due to incomplete sampling. Based upon these characteristics, we developed a prototype digital tomosynthesis R/F system for applications in chest imaging. Our prototype chest digital tomosynthesis (CDT) R/F system contains an X-ray tube with high power R/F pulse generator, flat-panel detector, R/F table, electromechanical radiographic subsystems including a precise motor controller, and a reconstruction server. For image reconstruction, users select between analytic and iterative reconstruction methods. Our reconstructed images of Catphan700 and LUNGMAN phantoms clearly and rapidly described the internal structures of phantoms using graphics processing unit (GPU) programming. Contrast-to-noise ratio (CNR) values of the CTP682 module of Catphan700 were higher in images using a simultaneous algebraic reconstruction technique (SART) than in those using filtered back-projection (FBP) for all materials by factors of 2.60, 3.78, 5.50, 2.30, 3.70, and 2.52 for air, lung foam, low density polyethylene (LDPE), Delrin® (acetal homopolymer resin), bone 50% (hydroxyapatite), and Teflon, respectively. Total elapsed times for producing 3D volume were 2.92 s and 86.29 s on average for FBP and SART (20 iterations), respectively. The times required for reconstruction were clinically feasible. Moreover, the total radiation dose from our system (5.68 mGy) was lower than that of conventional chest CT scan. Consequently, our prototype tomosynthesis R/F system represents an important advance in digital tomosynthesis applications.

  14. Hydrogen production as a novel process of wastewater treatment - studies on tofu wastewater with entrapped R. sphaeroides and mutagenesis

    Energy Technology Data Exchange (ETDEWEB)

    Heguang Zhu [Tongji Univ., Shanghai (China). Inst. of Environmental Science; Ueda, Shunsaku [Utsunomiya Univ. (Japan). Dept. of Biological Productive Science; Asada, Yasio [Nihon Univ., Chiba (Japan). College of Science and Technology; Miyake, Jun [National Inst. for Advanced Interdisciplinary Research, Ibaraki (Japan)

    2002-12-01

    Attention is focusing on hydrogen production from wastewater, not only because hydrogen is a clean energy but also because it can be a process for wastewater treatment. In this paper, the characteristics of biological hydrogen production as a process of wastewater treatment is discussed by a comparison with methane production. The hydrogen production from tofu wastewater by anoxygenic phototrophic bacteria and its potential for wastewater treatment are reported. The possibility of co-cultivation with heterotrophic anaerobic bacteria was also investigated. As a solution to overcome the repressive effect of NH{sub 4}{sup +} on hydrogen production by anoxygenic phototrophic bacteria, a study was done using glutamine auxotroph which was obtained by chemical mutagenesis. To confirm that the mutation had occurred in DNA molecular level, the glutamine synthetase gene was cloned and sequenced. (Author)

  15. NOL11, implicated in the pathogenesis of North American Indian childhood cirrhosis, is required for pre-rRNA transcription and processing.

    Directory of Open Access Journals (Sweden)

    Emily F Freed

    Full Text Available The fundamental process of ribosome biogenesis requires hundreds of factors and takes place in the nucleolus. This process has been most thoroughly characterized in baker's yeast and is generally well conserved from yeast to humans. However, some of the required proteins in yeast are not found in humans, raising the possibility that they have been replaced by functional analogs. Our objective was to identify non-conserved interaction partners for the human ribosome biogenesis factor, hUTP4/Cirhin, since the R565W mutation in the C-terminus of hUTP4/Cirhin was reported to cause North American Indian childhood cirrhosis (NAIC. By screening a yeast two-hybrid cDNA library derived from human liver, and through affinity purification followed by mass spectrometry, we identified an uncharacterized nucleolar protein, NOL11, as an interaction partner for hUTP4/Cirhin. Bioinformatic analysis revealed that NOL11 is conserved throughout metazoans and their immediate ancestors but is not found in any other phylogenetic groups. Co-immunoprecipitation experiments show that NOL11 is a component of the human ribosomal small subunit (SSU processome. siRNA knockdown of NOL11 revealed that it is involved in the cleavage steps required to generate the mature 18S rRNA and is required for optimal rDNA transcription. Furthermore, abnormal nucleolar morphology results from the absence of NOL11. Finally, yeast two-hybrid analysis shows that NOL11 interacts with the C-terminus of hUTP4/Cirhin and that the R565W mutation partially disrupts this interaction. We have therefore identified NOL11 as a novel protein required for the early stages of ribosome biogenesis in humans. Our results further implicate a role for NOL11 in the pathogenesis of NAIC.

  16. Urban RoGeR: Merging process-based high-resolution flash flood model for urban areas with long-term water balance predictions

    Science.gov (United States)

    Weiler, M.

    2016-12-01

    Heavy rain induced flash floods are still a serious hazard and generate high damages in urban areas. In particular in the spatially complex urban areas, the temporal and spatial pattern of runoff generation processes at a wide spatial range during extreme rainfall events need to be predicted including the specific effects of green infrastructure and urban forests. In addition, the initial conditions (soil moisture pattern, water storage of green infrastructure) and the effect of lateral redistribution of water (run-on effects and re-infiltration) have to be included in order realistically predict flash flood generation. We further developed the distributed, process-based model RoGeR (Runoff Generation Research) to include the relevant features and processes in urban areas in order to test the effects of different settings, initial conditions and the lateral redistribution of water on the predicted flood response. The uncalibrated model RoGeR runs at a spatial resolution of 1*1m² (LiDAR, degree of sealing, landuse), soil properties and geology (1:50.000). In addition, different green infrastructures are included into the model as well as the effect of trees on interception and transpiration. A hydraulic model was included into RoGeR to predict surface runoff, water redistribution, and re-infiltration. During rainfall events, RoGeR predicts at 5 min temporal resolution, but the model also simulates evapotranspiration and groundwater recharge during rain-free periods at a longer time step. The model framework was applied to several case studies in Germany where intense rainfall events produced flash floods causing high damage in urban areas and to a long-term research catchment in an urban setting (Vauban, Freiburg), where a variety of green infrastructures dominates the hydrology. Urban-RoGeR allowed us to study the effects of different green infrastructures on reducing the flood peak, but also its effect on the water balance (evapotranspiration and groundwater

  17. Beta-decay of nuclei around Se-90. Search for signatures of a N=56 sub-shell closure relevant the r-process

    CERN Document Server

    Quinn, M; Pereira, J; Surman, R; Arndt, O; Baumann, T; Becerril, A; Elliot, T; Estrade, A; Galaviz, D; Ginter, T; Hausmann, M; Hennrich, S; Kessler, R; Kratz, K -L; Lorusso, G; Mantica, P F; Matos, M; Moller, P; Montes, F; Pfeiffer, B; Portillo, M; Hennrich, S; Schatz, H; Schertz, F; Schnorrenberger, L; Smith, E; Stolz, A; Walters, W B; Wohr, A

    2011-01-01

    Nuclear structure plays a significant role on the rapid neutron capture process (r-process) since shapes evolve with the emergence of shells and sub-shells. There was some indication in neighboring nuclei that we might find examples of a new N=56 sub-shell, which may give rise to a doubly magic Se-90 nucleus. Beta-decay half lives of nuclei around Se-90 have been measured to determine if this nucleus has in fact a doubly-magic character. The fragmentation of Xe-136 beam at the National Superconducting Cyclotron Laboratory at Michigan State University was used to create a cocktail of nuclei in the A=90 region. We have measured the half lives of twenty-two nuclei near the r-process path in the A=90 region. The half lives of As-88 and Se-90 have been measured for the first time. The values were compared with theoretical predictions in the search for nuclear-deformation signatures of a N=56 sub-shell, and its possible role in the emergence of a potential doubly-magic Se-90. The impact of such hypothesis on the sy...

  18. Half-lives and branchings for {\\beta}-delayed neutron emission for neutron-rich Co-Cu isotopes in the r-process

    CERN Document Server

    Hosmer, P; Aprahamian, A; Arndt, O; Clement, R R C; Estrade, A; Farouqi, K; Kratz, K -L; Liddick, S N; Lisetskiy, A F; Mantica, P F; Möller, P; Mueller, W F; Montes, F; Morton, A C; Ouellette, M; Pellegrini, E; Pereira, J; Pfeiffer, B; Reeder, P; Santi, P; Steiner, M; Stolz, A; Tomlin, B E; Walters, W B; Wöhr, A; 10.1103/PhysRevC.82.025806

    2010-01-01

    The {\\beta} decays of very neutron-rich nuclides in the Co-Zn region were studied experimentally at the National Superconducting Cyclotron Laboratory using the NSCL {\\beta}-counting station in conjunction with the neutron detector NERO. We measured the branchings for {\\beta}-delayed neutron emission (Pn values) for 74Co (18 +/- 15%) and 75-77Ni (10 +/- 2.8%, 14 +/- 3.6%, and 30 +/- 24%, respectively) for the first time, and remeasured the Pn values of 77-79Cu, 79,81Zn, and 82Ga. For 77-79Cu and for 81Zn we obtain significantly larger Pn values compared to previous work. While the new half-lives for the Ni isotopes from this experiment had been reported before, we present here in addition the first half-life measurements of 75Co (30 +/- 11 ms) and 80Cu (170+110 -50 ms). Our results are compared with theoretical predictions, and their impact on various types of models for the astrophysical rapid neutron-capture process (r-process) is explored. We find that with our new data, the classical r-process model is bet...

  19. r.avaflow: An advanced open source computational framework for the GIS-based simulation of two-phase mass flows and process chains

    Science.gov (United States)

    Mergili, Martin; Fischer, Jan-Thomas; Fellin, Wolfgang; Ostermann, Alexander; Pudasaini, Shiva P.

    2015-04-01

    Geophysical mass flows stand for a broad range of processes and process chains such as flows and avalanches of snow, soil, debris or rock, and their interactions with water bodies resulting in flood waves. Despite considerable efforts put in model development, the simulation, and therefore the appropriate prediction of these types of events still remains a major challenge in terms of the complex material behaviour, strong phase interactions, process transformations and the complex mountain topography. Sophisticated theories exist, but they have hardly been brought to practice yet. We fill this gap by developing a novel and unified high-resolution computational tool, r.avaflow, representing a comprehensive and advanced open source GIS simulation environment for geophysical mass flows. Based on the latest and most advanced two-phase physical-mathematical models, r.avaflow includes the following features: (i) it is suitable for a broad spectrum of mass flows such as rock, rock-ice and snow avalanches, glacial lake outburst floods, debris and hyperconcentrated flows, and even landslide-induced tsunamis and submarine landslides, as well as process chains involving more than one of these phenomena; (ii) it accounts for the real two-phase nature of many flow types: viscous fluids and solid particles are considered separately with advanced mechanics and strong phase interactions; (iii) it is freely available and adoptable along with the GRASS GIS software. In the future, it will include the intrinsic topographic influences on the flow dynamics and morphology as well as an advanced approach to simulate the entrainment and deposition of solid and fluid material. As input r.avaflow needs information on (a) the mountain topography, (b) the material properties and (c) the spatial distribution of the solid and fluid release masses or one or more hydrographs of fluid and solid material. We demonstrate the functionalities and performance of r.avaflow by using some generic and real

  20. Beta-decay half-lives and beta-delayed neutron emisison probabilities of nuclei in the region A. 110, relevant for the r-process

    Energy Technology Data Exchange (ETDEWEB)

    Moller, Peter [Los Alamos National Laboratory; Pereira, J [MSU; Hennrich, S [MSU; Aprahamian, A [UNIV OF NOTRE DAME; Arndt, O [GERMANY; Becerril, A [MSU; Elliot, T [MSU; Estrade, A [MSU; Galaviz, D [MSU; Kessler, R [UNIV MAINZ; Kratz, K - L [GERMANY; Lorusso, G [MSU; Mantica, P F [MSU; Matos, M [MSU; Montes, F [MSU; Pfeiffer, B [UNIV MAINZ; Schatz, F [MSU; Schnorrenberger, L [GERMANY; Smith, E [MSU; Stolz, A [MSU; Quinn, M [UNIV OF NOTRE DAME; Walters, W B [UNIV OF MARYLAND; Wohr, A [UNIV OF NOTRE DAME

    2009-01-01

    Measurements of the {beta}-decay properties of A {approx}< 110 r-process nuclei have been completed at the National Superconducting Cyclotron Laboratory, at Michigan State University. {beta}-decay half-lives for {sup 105}Y, {sup 106,107}Zr and {sup 108,111}Mo, along with ,B-delayed neutron emission probabilities of 104Y, 109,11OMo and upper limits for 105Y, 103-107Zr and 108,111 Mo have been measured for the first time. Studies on the basis of the quasi-random phase approximation are used to analyze the ground-state deformation of these nuclei.

  1. The drivers of transnational subsidiary evolution: the upgrading of process R&D in the Irish pharmaceutical industry (NIRSA) Working Paper Series. No. 38

    OpenAIRE

    Van Egeraat, Chris; Breathnach, Proinnsias

    2008-01-01

    This paper contributes to the theory of subsidiary evolution in large corporations through an examination of the driving forces behind recent upgrading of process R&D activities in the Irish pharmaceutical industry. It is based on a survey of 80 pharmaceutical establishments in Ireland and a follow-up set of 52 semi-structured, face-to-face interviews with senior staff at 12 of the surveyed establishments carried out in 2006. We show that vigorous growth is occurring in the inc...

  2. Beta-decay half-lives and beta-delayed neutron emission probabilities of nuclei in the region below A=110, relevant for the r-process

    CERN Document Server

    Pereira, J; Aprahamian, A; Arndt, O; Becerril, A; Elliot, T; Estrade, A; Galaviz, D; Kessler, R; Kratz, K -L; Lorusso, G; Mantica, P F; Matos, M; Møller, P; Montes, F; Pfeiffer, B; Schatz, H; Schertz, F; Schnorrenberger, L; Smith, E; Stolz, A; Quinn, M; Walters, W B; Wöhr, A

    2009-01-01

    Measurements of the beta-decay properties of r-process nuclei below A=110 have been completed at the National Superconducting Cyclotron Laboratory, at Michigan State University. Beta-decay half-lives for Y-105, Zr-106,107 and Mo-111, along with beta-delayed neutron emission probabilities of Y-104, Mo-109,110 and upper limits for Y-105, Zr-103,104,105,106,107 and Mo-108,111 have been measured for the first time. Studies on the basis of the quasi-random phase approximation are used to analyze the ground-state deformation of these nuclei.

  3. β-decay half-lives and β-delayed neutron emission probabilities of nuclei in the region A≲110, relevant for the r process

    Science.gov (United States)

    Pereira, J.; Hennrich, S.; Aprahamian, A.; Arndt, O.; Becerril, A.; Elliot, T.; Estrade, A.; Galaviz, D.; Kessler, R.; Kratz, K.-L.; Lorusso, G.; Mantica, P. F.; Matos, M.; Möller, P.; Montes, F.; Pfeiffer, B.; Schatz, H.; Schertz, F.; Schnorrenberger, L.; Smith, E.; Stolz, A.; Quinn, M.; Walters, W. B.; Wöhr, A.

    2009-03-01

    Measurements of β-decay properties of A≲110 r-process nuclei have been completed at the National Superconducting Cyclotron Laboratory at Michigan State University. β-decay half-lives for Y105, Zr106,107, and Mo111, along with β-delayed neutron emission probabilities of Y104, Mo109,110 and upper limits for Y105, Zr103-107, and Mo108,111 have been measured for the first time. Studies on the basis of the quasi-random-phase approximation are used to analyze the ground-state deformation of these nuclei.

  4. Determination of Gluten in Processed and Nonprocessed Corn Products by Qualitative R5 Immunochromatographic Dipstick: Collaborative Study, First Action 2015.16.

    Science.gov (United States)

    Lacorn, Markus; Weiss, Thomas; Uhlig, Steffen; Scherf, Katharina

    2016-05-11

    In September 2013, the AACC International (AACI) Protein Technical Committee (now Protein and Enzymes Technical Committee) initiated a collaborative study of a method for the qualitative analysis of intact gluten in processed and nonprocessed corn products, using an R5 immunochromatographic dipstick system. It was validated to demonstrate that potential gluten-free products contain gluten lower than the Codex threshold of 20 mg/kg gluten. The results of the collaborative test with 18 participants confirmed that the method is suitable to detect gluten contaminations that are clearly lower than the threshold. It is recommended that the method be accepted by AOAC as Official First Action.

  5. R Fluids

    Directory of Open Access Journals (Sweden)

    Caimmi, R.

    2008-06-01

    Full Text Available A theory of collisionless fluids is developed in a unified picture, where nonrotating $(widetilde{Omega_1}=widetilde{Omega_2}= widetilde{Omega_3}=0$ figures with some given random velocity component distributions, and rotating $(widetilde{Omega_1} ewidetilde{Omega_2} e widetilde{Omega_3} $ figures with a different random velocity component distributions, make adjoint configurations to the same system. R fluids are defined as ideal, self-gravitating fluids satisfying the virial theorem assumptions, in presence of systematic rotation around each of the principal axes of inertia. To this aim, mean and rms angular velocities and mean and rms tangential velocity components are expressed, by weighting on the moment of inertia and the mass, respectively. The figure rotation is defined as the mean angular velocity, weighted on the moment of inertia, with respectto a selected axis. The generalized tensor virial equations (Caimmi and Marmo 2005 are formulated for R fluidsand further attention is devoted to axisymmetric configurations where, for selected coordinateaxes, a variation in figure rotation has to be counterbalanced by a variation in anisotropy excess and viceversa. A microscopical analysis of systematic and random motions is performed under a fewgeneral hypotheses, by reversing the sign of tangential or axial velocity components of anassigned fraction of particles, leaving the distribution function and other parametersunchanged (Meza 2002. The application of the reversion process to tangential velocitycomponents is found to imply the conversion of random motion rotation kinetic energy intosystematic motion rotation kinetic energy. The application ofthe reversion process to axial velocity components is found to imply the conversionof random motion translation kinetic energy into systematic motion translation kinetic energy, and theloss related to a change of reference frame is expressed in terms of systematic motion (imaginary rotation kinetic

  6. R fluids

    Directory of Open Access Journals (Sweden)

    Caimmi R.

    2008-01-01

    Full Text Available A theory of collisionless fluids is developed in a unified picture, where nonrotating (Ωf1 = Ωf2 = Ωf3 = 0 figures with some given random velocity component distributions, and rotating (Ωf1 = Ωf2 = Ωf3 figures with a different random velocity component distributions, make adjoint configurations to the same system. R fluids are defined as ideal, self-gravitating fluids satisfying the virial theorem assumptions, in presence of systematic rotation around each of the principal axes of inertia. To this aim, mean and rms angular velocities and mean and rms tangential velocity components are expressed, by weighting on the moment of inertia and the mass, respectively. The figure rotation is defined as the mean angular velocity, weighted on the moment of inertia, with respect to a selected axis. The generalized tensor virial equations (Caimmi and Marmo 2005 are formulated for R fluids and further attention is devoted to axisymmetric configurations where, for selected coordinate axes, a variation in figure rotation has to be counterbalanced by a variation in anisotropy excess and vice versa. A microscopical analysis of systematic and random motions is performed under a few general hypotheses, by reversing the sign of tangential or axial velocity components of an assigned fraction of particles, leaving the distribution function and other parameters unchanged (Meza 2002. The application of the reversion process to tangential velocity components is found to imply the conversion of random motion rotation kinetic energy into systematic motion rotation kinetic energy. The application of the reversion process to axial velocity components is found to imply the conversion of random motion translation kinetic energy into systematic motion translation kinetic energy, and the loss related to a change of reference frame is expressed in terms of systematic motion (imaginary rotation kinetic energy. A number of special situations are investigated in greater

  7. Assessing the reliability and validity of the Revised Two Factor Study Process Questionnaire (R-SPQ2F in Ghanaian medical students

    Directory of Open Access Journals (Sweden)

    Victor Mogre

    2014-08-01

    Full Text Available Purpose: We investigated the validity and reliability of the Revised Two Factor Study Process Questionnaire (R-SPQ2F in preclinical students in Ghana. Methods: The R-SPQ2F was administered to 189 preclinical students of the University for Development Studies, School of Medicine and Health Sciences. Both descriptive and inferential statistics with Cronbach’s alpha test and factor analysis were done. Results: The mean age of the students was 22.69 ± 0.18 years, 60.8% (n = 115 were males and 42.3% (n = 80 were in their second year of medical training. The students had higher mean deep approach scores (31.23 ± 7.19 than that of surface approach scores (22.62 ± 6.48. Findings of the R-SPQ2F gave credence to a solution of two-factors indicating deep and surface approaches accounting for 49.80% and 33.57%, respectively, of the variance. The scales of deep approach (Cronbach’s alpha, 0.80 and surface approach (Cronbach’s alpha, 0.76 and their subscales demonstrated an internal consistency that was good. The factorial validity was comparable to other studies. Conclusion: Our study confirms the construct validity and internal consistency of the R-SPQ2F for measuring approaches to learning in Ghanaian preclinical students. Deep approach was the most dominant learning approach among the students. The questionnaire can be used to measure students’ approaches to learning in Ghana and in other African countries.

  8. R&D Project Selection Using the Analytic Network Process%运用网络分析法选择R&D项目

    Institute of Scientific and Technical Information of China (English)

    黄本笑; 彭玉梅

    2003-01-01

    网络分析法(Analytic Network Process,简称ANP)是层次分析法(Analytic Hierarchy Process,简称AHP)的一种特殊形式.ANP模型充分考虑各层次之间以及同一层之间各元素的相互作用关系,对各方案进行综合评价并得出最佳决策.文章主要以R&D项目的选择为例,通过ANP模型的应用可看出ANP是一种帮助组织进行决策的高效实用的计算工具.

  9. Neutron-Capture Elements in the Double-Enhanced Star HE 1305-0007: a New sand r-Process Paradigm

    Institute of Scientific and Technical Information of China (English)

    GUI Wen-Yuan; CUI Dong-Nuan; DU Yun-Shuang; ZHANG Bo

    2007-01-01

    The star HE 1305-0007 is a metal-poor double-enhanced star with metallicity [Fe/H] = -2.0,which is just at the upper limit of the metallicity for the observed double-enhanced stars. Using a parametric model, we find that almost all s-elements were made in a single neutron exposure. This star should be a member of a post-common-envelope binary. After the s-process material has experienced only one neutron exposure in the nucleosynthesis region and is dredged-up to its envelope, he AGB evolution is terminated by the onset of common-envelope evolution. Based on the high radial-velocity of HE 1305-0007,we speculate that the star could be a runaway star from a binary system, in which the AIC event has occurred and produced the r-process elements.

  10. The 3R anthracite clean coal technology: Economical conversion of brown coal to anthracite type clean coal by low temperature carbonization pre-treatment process

    Directory of Open Access Journals (Sweden)

    Someus Edward

    2006-01-01

    Full Text Available The preventive pre-treatment of low grade solid fuels is safer, faster, better, and less costly vs. the "end-of-the-pipe" post treatment solutions. The "3R" (Recycle-Reduce-Reuse integrated environment control technology provides preventive pre-treatment of low grade solid fuels, such as brown coal and contaminated solid fuels to achieve high grade cleansed fuels with anthracite and coke comparable quality. The goal of the 3R technology is to provide cost efficient and environmentally sustainable solutions by preventive pre-treatment means for extended operations of the solid fuel combustion power plants with capacity up to 300 MWe power capacities. The 3R Anthracite Clean Coal end product and technology may advantageously be integrated to the oxyfuel-oxy-firing, Foster Wheeler anthracite arc-fired utility type boiler and Heat Pipe Reformer technologies in combination with CO2 capture and storage programs. The 3R technology is patented original solution. Advantages. Feedstock flexibility: application of pre-treated multi fuels from wider fuel selection and availability. Improved burning efficiency. Technology flexibility: efficient and advantageous inter-link to proven boiler technologies, such as oxyfuel and arcfired boilers. Near zero pollutants for hazardous-air-pollutants: preventive separation of halogens and heavy metals into small volume streams prior utilization of cleansed fuels. >97% organic sulphur removal achieved by the 3R thermal pre-treatment process. Integrated carbon capture and storage (CCS programs: the introduction of monolitic GHG gas is improving storage safety. The 3R technology offers significant improvements for the GHG CCS conditions. Cost reduction: decrease of overall production costs when all real costs are calculated. Improved safety: application of preventive measures. For pre-treatment a specific purpose designed, developed, and patented pyrolysis technology used, consisting of a horizontally arranged externally

  11. Neutron Star Mergers as the Origin of r-Process Elements in the Galactic Halo Based on the Sub-halo Clustering Scenario

    CERN Document Server

    Ishimaru, Yuhri; Prantzos, Nikos

    2015-01-01

    Binary mergers (NSMs) of double neutron star (and black hole-neutron star) systems are suggested to be major sites of r-process elements in the Galaxy by recent hydrodynamical and nucleosynthesis studies. It has been pointed out, however, that the estimated long lifetimes of neutron star binaries are in conflict with the presence of r-process-enhanced halo stars at metallicities as low as [Fe/H] ~ -3. To resolve this problem, we examine the role of NSMs in the early Galactic chemical evolution on the assumption that the Galactic halo was formed from merging sub-halos. We present simple models for the chemical evolution of sub-halos with total final stellar masses between 10^4 M_solar and 2 x 10^8 M_solar. Typical lifetimes of compact binaries are assumed to be 100 Myr (for 95% of their population) and 1 Myr (for 5%), according to recent binary population synthesis studies. The resulting metallcities of sub-halos and their ensemble are consistent with the observed mass-metallicity relation of dwarf galaxies in...

  12. The astrophysical r-process and its dependence on properties of nuclei far from stability beta strength functions and neutron capture rates

    CERN Document Server

    Klapdor-Kleingrothaus, H V; Metzinger, J; Oda, T; Thielemann, F K

    1981-01-01

    It is shown that the astrophysical r-process and the question of its site are very sensitive to 'standard' nuclear physics parameters like the beta decay properties and neutron capture rates. Since for these quantities in almost all r-process calculations up to now, and also in all estimates of the production rates of chronometric pairs, only very rough assumptions have been made, it is attempted to present procedures which put the calculation of these quantities for nuclei far from stability on a reliable physical basis. This is done by a microscopic description of the beta strength function and by using a statistical model based on a 'next to first principles' optical potential including effects of deformation for the neutron capture rates. The beta -decay rates for approximately 6000 nuclei between the beta -stability line and the neutron drip line are calculated. The heavy element synthesis by explosive He burning then is calculated using these beta -rates and using realistic star models treating the supe...

  13. Methionine Regulates mTORC1 via the T1R1/T1R3-PLCβ-Ca2+-ERK1/2 Signal Transduction Process in C2C12 Cells

    Directory of Open Access Journals (Sweden)

    Yuanfei Zhou

    2016-10-01

    Full Text Available The mammalian target of rapamycin complex 1 (mTORC1 integrates amino acid (AA availability to support protein synthesis and cell growth. Taste receptor type 1 member (T1R is a G protein-coupled receptor that functions as a direct sensor of extracellular AA availability to regulate mTORC1 through Ca2+ stimulation and extracellular signal–regulated kinases 1 and 2 (ERK1/2 activation. However, the roles of specific AAs in T1R1/T1R3-regulated mTORC1 are poorly defined. In this study, T1R1 and T1R3 subunits were expressed in C2C12 myotubes, and l-AA sensing was accomplished by T1R1/T1R3 to activate mTORC1. In response to l-AAs, such as serine (Ser, arginine (Arg, threonine (Thr, alanine (Ala, methionine (Met, glutamine (Gln, and glycine (Gly, Met induced mTORC1 activation and promoted protein synthesis. Met also regulated mTORC1 via T1R1/T1R3-PLCβ-Ca2+-ERK1/2 signal transduction. Results revealed a new role for Met-regulated mTORC1 via an AA receptor. Further studies should be performed to determine the role of T1R1/T1R3 in mediating extracellular AA to regulate mTOR signaling and to reveal its mechanism.

  14. Methionine Regulates mTORC1 via the T1R1/T1R3-PLCβ-Ca2+-ERK1/2 Signal Transduction Process in C2C12 Cells

    Science.gov (United States)

    Zhou, Yuanfei; Ren, Jiao; Song, Tongxing; Peng, Jian; Wei, Hongkui

    2016-01-01

    The mammalian target of rapamycin complex 1 (mTORC1) integrates amino acid (AA) availability to support protein synthesis and cell growth. Taste receptor type 1 member (T1R) is a G protein-coupled receptor that functions as a direct sensor of extracellular AA availability to regulate mTORC1 through Ca2+ stimulation and extracellular signal–regulated kinases 1 and 2 (ERK1/2) activation. However, the roles of specific AAs in T1R1/T1R3-regulated mTORC1 are poorly defined. In this study, T1R1 and T1R3 subunits were expressed in C2C12 myotubes, and l-AA sensing was accomplished by T1R1/T1R3 to activate mTORC1. In response to l-AAs, such as serine (Ser), arginine (Arg), threonine (Thr), alanine (Ala), methionine (Met), glutamine (Gln), and glycine (Gly), Met induced mTORC1 activation and promoted protein synthesis. Met also regulated mTORC1 via T1R1/T1R3-PLCβ-Ca2+-ERK1/2 signal transduction. Results revealed a new role for Met-regulated mTORC1 via an AA receptor. Further studies should be performed to determine the role of T1R1/T1R3 in mediating extracellular AA to regulate mTOR signaling and to reveal its mechanism. PMID:27727170

  15. New insights into cinchonine-aluminium complexes and their application as chiral building blocks: unprecedented ligand-exchange processes in the presence of ZnR2 compounds.

    Science.gov (United States)

    Kaczorowski, Tomasz; Justyniak, Iwona; Prochowicz, Daniel; Zelga, Karolina; Kornowicz, Arkadiusz; Lewiński, Janusz

    2012-10-15

    Previous studies have demonstrated that [(CN)(2)AlCl] and [R(2)Al(μ-CN)](2) (CN=deprotonated cinchonine) complexes can effectively act as chiral, semirigid, N,N-ditopic metalloligands for Zn-containing nodes, and provide viable means for constructing new, homochiral, heterometallic, coordination polymers of zigzag and helical topologies. These findings have prompted further investigations on the organometallic analogues of the formula [(CN)(2)AlR], anticipating their utility as N,N-metalloligands for ZnR(2) units. Surprisingly, reactions of [(CN)(2)AlMe]-type metalloligands with ZnR(2) compounds (R=Me or Et) revealed unprecedented ligand-exchange processes, including zinc-to-aluminium and aluminium-to-zinc transmetalations of alkyl groups. The molecular and crystal structure of the resulting compounds was determined by X-ray diffraction analysis. From the reaction of [(CN)(2)AlMe] with ZnMe(2) a new pseudopolymorphic form of a noncovalent porous material based on [Me(2)Al(μ-CN)](2) molecules was isolated. Strikingly, the analogous reaction involving ZnEt(2) led to the generation of a new chiral 4N-tetratopic heterometalloligand [(CN)EtAl(μ-CN)(2)ZnEt]. The latter unit was successfully connected by alkyl-exchanged ZnMe(2) nodes to give an original homochiral heterometallic {[(CN)EtAl(μ-CN)(2)ZnEt]ZnMe(2)}(n) coordination polymer adopting a snake 1D motif. The outcome of the revealed reactions indicates the complicated multistep reaction route that involves redistribution of cinchonine and alkyl ligands among the Al and Zn centers, and a general reaction scheme is proposed. The results are in strong contrast with the previously studied inorganic-organic [(CN)(2)AlCl/ZnCl(2)] system, which exclusively affords a helical coordination polymer based on ZnCl(2) nodes and (CN)(2)AlCl metalloligands and lacks the exchange of CN ligands. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Mitigation of stress corrosion cracking in pressurized water reactor (PWR) piping systems using the mechanical stress improvement process (MSIP{sup R)} or underwater laser beam welding

    Energy Technology Data Exchange (ETDEWEB)

    Rick, Grendys; Marc, Piccolino; Cunthia, Pezze [Westinghouse Electric Company, LLC, New York (United States); Badlani, Manu [Nu Vision Engineering, New York (United States)

    2009-04-15

    A current issue facing pressurized water reactors (PWRs) is primary water stress corrosion cracking (PWSCC) of bi metallic welds. PWSCC in a PWR requires the presence of a susceptible material, an aggressive environment and a tensile stress of significant magnitude. Reducing the potential for SCC can be accomplished by eliminating any of these three elements. In the U.S., mitigation of susceptible material in the pressurizer nozzle locations has largely been completed via the structural weld overlay (SWOL) process or NuVision Engineering's Mechanical Stress Improvement Process (MSIP{sup R)}, depending on inspectability. The next most susceptible locations in Westinghouse designed power plants are the Reactor Vessel (RV) hot leg nozzle welds. However, a full SWOL Process for RV nozzles is time consuming and has a high likelihood of in process weld repairs. Therefore, Westinghouse provides two distinctive methods to mitigate susceptible material for the RV nozzle locations depending on nozzle access and utility preference. These methods are the MSIP and the Underwater Laser Beam Welding (ULBW) process. MSIP applies a load to the outside diameter of the pipe adjacent to the weld, imposing plastic strains during compression that are not reversed after unloading, thus eliminating the tensile stress component of SCC. Recently, Westinghouse and NuVision successfully applied MSIP on all eight RV nozzles at the Salem Unit 1 power plant. Another option to mitigate SCC in RV nozzles is to place a barrier between the susceptible material and the aggressive environment. The ULBW process applies a weld inlay onto the inside pipe diameter. The deposited weld metal (Alloy 52M) is resistant to PWSCC and acts as a barrier to prevent primary water from contacting the susceptible material. This paper provides information on the approval and acceptance bases for MSIP, its recent application on RV nozzles and an update on ULBW development.

  17. High-resolution microscopy of active ribosomal genes and key members of the rRNA processing machinery inside nucleolus-like bodies of fully-grown mouse oocytes.

    Science.gov (United States)

    Shishova, Kseniya V; Khodarovich, Yuriy M; Lavrentyeva, Elena A; Zatsepina, Olga V

    2015-10-01

    Nucleolus-like bodies (NLBs) of fully-grown (germinal vesicle, GV) mammalian oocytes are traditionally considered as morphologically distinct entities, which, unlike normal nucleoli, contain transcribed ribosomal genes (rDNA) solely at their surface. In the current study, we for the first time showed that active ribosomal genes are present not only on the surface but also inside NLBs of the NSN-type oocytes. The "internal" rRNA synthesis was evidenced by cytoplasmic microinjections of BrUTP as precursor and by fluorescence in situ hybridization with a probe to the short-lived 5'ETS segment of the 47S pre-rRNA. We further showed that in the NLB mass of NSN-oocytes, distribution of active rDNA, RNA polymerase I (UBF) and rRNA processing (fibrillarin) protein factors, U3 snoRNA, pre-rRNAs and 18S/28S rRNAs is remarkably similar to that in somatic nucleoli capable to make pre-ribosomes. Overall, these observations support the occurrence of rDNA transcription, rRNA processing and pre-ribosome assembly in the NSN-type NLBs and so that their functional similarity to normal nucleoli. Unlike the NSN-type NLBs, the NLBs of more mature SN-oocytes do not contain transcribed rRNA genes, U3 snoRNA, pre-rRNAs, 18S and 28S rRNAs. These results favor the idea that in a process of transformation of NSN-oocytes to SN-oocytes, NLBs cease to produce pre-ribosomes and, moreover, lose their rRNAs. We also concluded that a denaturing fixative 70% ethanol used in the study to fix oocytes could be more appropriate for light microscopy analysis of nucleolar RNAs and proteins in mammalian fully-grown oocytes than a commonly used cross-linking aldehyde fixative, formalin.

  18. Beta Decay Half-lives and Delayed Neutron Emission of r-process Neutron-Rich nuclei in the vicinity of 78Ni

    Science.gov (United States)

    Madurga, M.

    2012-10-01

    The region of neutron rich isotopes at and beyond the N=50 shell closure in the vicinity of ^78Ni has recently attracted major interest from experimental and theoretical nuclear physics community [1-4]. Moreover, as many nuclei in the region are predicted precursors of r-process nucleosynthesis, their most basic nuclear properties such as mass and beta decay half-life are required parameters in abundance calculations. The availability of hight purity and high quality radioactive beams of nuclei in this region at the Holifield Radioactive Ion Beam Facility has spurred a systematic campaign to study their properties through beta decay. Four new half-lives of ^82,83Zn, ^85Ga and ^86Ge were measured for the first time. The resulting values differ from the predictions of the Finite Range Droplet Model used in r-process abundance calculations. We presented a new model based on Density Functional Theory that correctly reproduced the new half-lives. The revised analysis of the rapid neutron capture process in low entropy environments with our new set of measured and calculated half-lives shows a significant redistribution of predicted isobaric abundances strengthening the yield of A > 140 nuclei. Continuing our effort to systematically understand decay properties in the region of beta-delayed neutron emission, 30 nuclei in the region were studied using the neutron energy Time-of-Flight detector VANDLE. Due to the shell structure in the region, most of the decay strength is expected to concentrate in states above neutron separation energy, in the so-called Pigmy Giant resonance. Precise knowledge of the position and strength of the resonance may help fine tune and develop existing models, with the aim of increasing their reliability beyond what can be experimentally measured. The data resulting from the experimental campaign at Holifield are still being analyzed. In a few species strong shell effects have already been identified and they will be presented. In particular

  19. The Dorsolateral Prefrontal Cortex Plays a Role in Self-Initiated Elaborative Cognitive Processing during Episodic Memory Encoding: rTMS Evidence

    Science.gov (United States)

    Hawco, Colin; Berlim, Marcelo T.; Lepage, Martin

    2013-01-01

    During episodic memory encoding, elaborative cognitive processing can improve later recall or recognition. While multiple studies examined the neural correlates of encoding strategies, few studies have explicitly focused on the self-initiation of elaborative encoding. Repetitive transcranial magnetic stimulation (rTMS), a method which can transiently disrupt neural activity, was administered during an associative encoding task. rTMS was either applied to the left dorsolateral prefrontal cortex (DLPFC) or to the vertex (a control region not involved in memory encoding) during presentation of pairs of words. Pairs could be semantically related or not related. Two encoding instructions were given, either cueing participants to analyze semantic relationships (cued condition), or to memorize the pair without any specific strategy cues (the self-initiated condition). Participants filled out a questionnaire regarding their use of memory strategies and performed a cued-recall task. We hypothesized that if the DLPFC plays a role in the self-initiation of elaborative encoding we would observe a reduction in memory performance in the self-initiated condition, particularly for related. We found a significant correlation between the effects of rTMS and strategy use, only in the self-initiated condition with related pairs. High strategy users showed reduced performance following DLPFC stimulation, while low strategy users tended to show increased recall following DLPFC stimulation during encoding. These results suggest the left DLPFC may be involved in the self-initiation of memory strategy use, and individuals may utilize different neural networks depending on their use of encoding strategies. PMID:24040072

  20. The dorsolateral prefrontal cortex plays a role in self-initiated elaborative cognitive processing during episodic memory encoding: rTMS evidence.

    Directory of Open Access Journals (Sweden)

    Colin Hawco

    Full Text Available During episodic memory encoding, elaborative cognitive processing can improve later recall or recognition. While multiple studies examined the neural correlates of encoding strategies, few studies have explicitly focused on the self-initiation of elaborative encoding. Repetitive transcranial magnetic stimulation (rTMS, a method which can transiently disrupt neural activity, was administered during an associative encoding task. rTMS was either applied to the left dorsolateral prefrontal cortex (DLPFC or to the vertex (a control region not involved in memory encoding during presentation of pairs of words. Pairs could be semantically related or not related. Two encoding instructions were given, either cueing participants to analyze semantic relationships (cued condition, or to memorize the pair without any specific strategy cues (the self-initiated condition. Participants filled out a questionnaire regarding their use of memory strategies and performed a cued-recall task. We hypothesized that if the DLPFC plays a role in the self-initiation of elaborative encoding we would observe a reduction in memory performance in the self-initiated condition, particularly for related. We found a significant correlation between the effects of rTMS and strategy use, only in the self-initiated condition with related pairs. High strategy users showed reduced performance following DLPFC stimulation, while low strategy users tended to show increased recall following DLPFC stimulation during encoding. These results suggest the left DLPFC may be involved in the self-initiation of memory strategy use, and individuals may utilize different neural networks depending on their use of encoding strategies.

  1. 贫金属星r过程核合成相关问题的研究进展%Progress of the Study About R-process Nucleosynthesis in Metal-poor Stars

    Institute of Scientific and Technical Information of China (English)

    张江; 崔文元; 张波

    2011-01-01

    快中子俘获过程(r过程)可以解释大约一半比铁重的稳定(和一些长寿命放射性的)富中子核素的产生,这已经被太阳系及各种金属丰度下恒星的观测结果所证实.为建立r过程模型,需要大量的核物理信息:涉及到β稳定谷与中子滴线之间的各种核素的稳定特性及β衰变分支等物理参数,实验和理论都面临巨大的挑战.综述了近年来贫金属星r过程核合成理论的研究情况,包括人们比较关注的主要r过程与弱r过程核合成、元素丰度分布规律及其产生场所等.%The rapid neutron-capture process (r-process) is traditionally believed to be responsible for the nucleosynthesis of approximately half of the heavy nuclei beyond the iron peak with long-decay half-lives in the solar material. In globular clusters and Galactic halo stars, the observed abundances show a nearly universal presence of r-process. With the rapid development of the abundance determinations, more elements (e.g., Lu, Z - 71) are firstly detected in metal-poor r-process-enriched halo stars, which can be used as the r-process indicators for the early Galaxy. Moreover, these r-rich stars provide a strong constraint on the models of the r-process nucleosynthesis, especially the early galaxy chemical evolution of neutron-capture elements.Based on new atomic lab data, recent neutron-capture abundance comparisons between six r-rich Galactic halo stars and the Solar System r-only abundance distribution indicate that the heavier stable neutron-capture elements beyond Ba (Z > 56) agree completely with a scaled solar system r-process abundance value. Nevertheless, the lighter neutron-capture elemental abundances in these stars are not in agreement with Solar-system r-only values. Although there is controversy over the origin of weak r-process, the neutron-capture elements are proposed to be formed possibly from multiple synthesis mechanisms, even if there exists little uncertainty. Whether the r-process

  2. Optimization of process parameters for the electrical properties in Ga-doped ZnO thin films prepared by r.f. magnetron sputtering

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, D.L., E-mail: dlzhu@szu.edu.cn [College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060 (China); Shenzhen Key Laboratory of Special Functional Materials, Shenzhen University, Shenzhen 518060 (China); Wang, Q.; Han, S.; Cao, P.J.; Liu, W.J.; Jia, F.; Zeng, Y.X.; Ma, X.C. [College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060 (China); Shenzhen Key Laboratory of Special Functional Materials, Shenzhen University, Shenzhen 518060 (China); Lu, Y.M., E-mail: ymlu@szu.edu.cn [College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060 (China); Shenzhen Key Laboratory of Special Functional Materials, Shenzhen University, Shenzhen 518060 (China)

    2014-04-01

    Highlights: • ρ in GZO films significantly reduces after optimization of parameters by Taguchi method. • ANOVA shows that vacuum annealing is the most significant influencing parameter on ρ. • XPS and PL results show that ρ decrease after annealing is due to the variation of oxygen. • The content of absorbed oxygen and O{sub i} as acceptors will decrease after annealing. - Abstract: Ga-doped ZnO (GZO) transparent conductive thin films have been deposited on quartz substrates by r.f. magnetron sputtering. The optimization of four process parameters (i.e., vacuum annealing temperature, r.f. power, sputtering pressure, and Ar flow rate) based on Taguchi method has been systematically studied in order to obtain the minimum resistivity. Compared to the optimal parameter set selected from orthogonal array by Taguchi method, the optimal prediction design can receive an improvement of 22.3% in electrical resistivity, and the corresponding resistivity is 8.08 × 10{sup −4} Ω cm. The analysis of variance shows that vacuum annealing temperature is the most significant influencing parameter on the electrical properties in GZO films. X-ray photoelectron spectroscopy and photoluminescence results exhibit that the enhancement in electrical conductivity after vacuum annealing is ascribed to the variation of the chemical states of oxygen in GZO films. With the increase in annealing temperature, the content of absorbed oxygen and interstitial oxygen as acceptors will decrease.

  3. Neutron-Rich Silver Isotopes Produced by a Chemically Selective Laser Ion-Source: Test of the R-Process " Waiting-Point " Concept

    CERN Multimedia

    2002-01-01

    The r-process is an important nucleosynthesis mechanism for several reasons: \\begin{enumerate} \\item It is crucial to an understanding of about half of the A>60 elemental composition of the Galaxy; \\item It is the mechanism that forms the long-lived Th-U-Pu nuclear chronometers which are used for cosmochronolgy; \\item It provides an important probe for the temperature (T$ _{9} $)-neutron density ($n_{n}$) conditions in explosive events; and last but not least \\item It may serve to provide useful clues to and constraints upon the nuclear properties of very neutron-rich heavy nuclei. \\end{enumerate} \\\\ \\\\With regard to nuclear-physics data, of particular interest are the T$ _{1/2} $ and P$_{n-} $ values of certain$\\,$ "waiting-point"$\\,$ isotopes in the regions of the A $ \\approx $ 80 and 130. r-abundance peaks. Previous studies of $^{130}_{\\phantom{1}48}$Cd$_{82}$ and $^{79}_{29}$Cu$_{50}$. $\\beta$-decay properties at ISOLDE using a hot plasma ion source were strongly complicated by isobar and molecular-ion c...

  4. 基于PMBOK的产品研发过程测试管理研究%Research on Test Management of Products' R & D Process Based on PMBOK

    Institute of Scientific and Technical Information of China (English)

    王建伟; 崔忠民; 房卫东

    2012-01-01

    We analyses the situations of test management based on R & D process of products, and research the architecture of product test management combined with the PMBOK (A Guide to the Project Management Body of Knowledge). Some exploratory proposals are submitted, such as "Test Integrated Management of R & D", "Test Team Building", and so on. Finally, we give the prospect of the application of architecture of product test management.%本文通过产品研发过程测试管理现状的分析,并结合PMBOK(项目管理知识体系A Guide to the Project Management Body ofKnowledge),对产品测试管理体系进行了研究,提出了“产品研发的测试整合管理”、“测试团队建设”等一系列加强产品测试管理的探索性建议,最后,简要描绘了产品研发过程的测试管理体系应用的前景.

  5. Some notes on the activities of R and D of radiation processing and their prospects toward the year 2000 in Indonesia

    Energy Technology Data Exchange (ETDEWEB)

    Manurung, S.; Chosdu, R.; Marga, U.; Natsir, M.; Danu, S.; Hilmy, N. [Center for Research and Development of Isotopes and Radiation Technologies, National Nuclear Energy Agency, Jakarta (Indonesia)

    2000-03-01

    Research and Development activities in radiation polymerization, sterilization, food preservation and radiation dosimetry started in early 1970. The basic idea of R and D is to strengthen and broaden the linkage between industry and research institute, which in turn results in the economic growth of the country. Past experiences in radiation vulcanization of natural rubber latex (RVNRL), wood surface coating, sterilization, and food preservation activities have given some benefits to industry as well as to the research in term of transfer of technology and know-how. Intended for commercial purposes, the radiation technology has been applied by two national private companies i.e. PT. Indogamma and PT. Gajah Tunggal, while in the lab. scale activities of BATAN, R and D are focused on the development of methodology. However, some problems related to existing resources, i.e. finance, machine, legal, psycho-social, have to be solved thoroughly in order to obtain maximum results and benefits national wide. At present, there are 6 Gamma Irradiators and 3 Electron Accelerators to carry out all the radiation processing activities, and it is our primary commitment to develop the methodology and its applications toward the year 2000. For this reason, collaboration with all of relevant institutes or organizations is considered to be urgent and important. (author)

  6. SWATH2stats: An R/Bioconductor Package to Process and Convert Quantitative SWATH-MS Proteomics Data for Downstream Analysis Tools.

    Science.gov (United States)

    Blattmann, Peter; Heusel, Moritz; Aebersold, Ruedi

    2016-01-01

    SWATH-MS is an acquisition and analysis technique of targeted proteomics that enables measuring several thousand proteins with high reproducibility and accuracy across many samples. OpenSWATH is popular open-source software for peptide identification and quantification from SWATH-MS data. For downstream statistical and quantitative analysis there exist different tools such as MSstats, mapDIA and aLFQ. However, the transfer of data from OpenSWATH to the downstream statistical tools is currently technically challenging. Here we introduce the R/Bioconductor package SWATH2stats, which allows convenient processing of the data into a format directly readable by the downstream analysis tools. In addition, SWATH2stats allows annotation, analyzing the variation and the reproducibility of the measurements, FDR estimation, and advanced filtering before submitting the processed data to downstream tools. These functionalities are important to quickly analyze the quality of the SWATH-MS data. Hence, SWATH2stats is a new open-source tool that summarizes several practical functionalities for analyzing, processing, and converting SWATH-MS data and thus facilitates the efficient analysis of large-scale SWATH/DIA datasets.

  7. Sensitivity of tensor analyzing power in the process d+p{r_arrow}d+X to the longitudinal isoscalar form factor of the Roper resonance electroexcitation

    Energy Technology Data Exchange (ETDEWEB)

    Tomasi-Gustafsson, E.; Rekalo, M.P. [DSM-CEA/IN2P3-CNRS, Laboratoire National Saturne, F-91191 Gif-sur-Yvette Cedex (France)]|[DAPNIA/SPhN, C.E.A./Saclay, F-91191 Gif-sur-Yvette Cedex (France); Bijker, R. [Instituto de Ciencias Nucleares, U.N.A.M., A.P. 70-543, 04510 Mexico Distrito Federal (Mexico); Leviatan, A. [Racah Institute of Physics, The Hebrew University, Jerusalem 91904 (Israel); Iachello, F. [Center for Theoretical Physics, Sloane Laboratory, Yale University, New Haven, Connecticut 06520-8120 (United States)

    1999-03-01

    The tensor analyzing power of the process d+p{r_arrow}d+X, for forward deuteron scattering in the momentum interval 3.7 to 9 GeV/c, is studied in the framework of {omega} exchange in an algebraic collective model for the electroexcitation of nucleon resonances. We point out a special sensitivity of the tensor analyzing power to the isoscalar longitudinal form factor of the Roper resonance excitation. The main argument is that the S{sub 11}(1535),thinspD{sub 13}(1520), and S{sub 11}(1650) resonances have only isovector longitudinal form factors. It is the longitudinal form factor of the Roper excitation, which plays an important role in the {ital t} dependence of the tensor analyzing power. We discuss possible evidence of swelling of hadrons with increasing excitation energy. {copyright} {ital 1999} {ital The American Physical Society}

  8. 94 β -Decay Half-Lives of Neutron-Rich Cs 55 to Ho 67 : Experimental Feedback and Evaluation of the r -Process Rare-Earth Peak Formation

    Science.gov (United States)

    Wu, J.; Nishimura, S.; Lorusso, G.; Möller, P.; Ideguchi, E.; Regan, P.-H.; Simpson, G. S.; Söderström, P.-A.; Walker, P. M.; Watanabe, H.; Xu, Z. Y.; Baba, H.; Browne, F.; Daido, R.; Doornenbal, P.; Fang, Y. F.; Gey, G.; Isobe, T.; Lee, P. S.; Liu, J. J.; Li, Z.; Korkulu, Z.; Patel, Z.; Phong, V.; Rice, S.; Sakurai, H.; Sinclair, L.; Sumikama, T.; Tanaka, M.; Yagi, A.; Ye, Y. L.; Yokoyama, R.; Zhang, G. X.; Alharbi, T.; Aoi, N.; Bello Garrote, F. L.; Benzoni, G.; Bruce, A. M.; Carroll, R. J.; Chae, K. Y.; Dombradi, Z.; Estrade, A.; Gottardo, A.; Griffin, C. J.; Kanaoka, H.; Kojouharov, I.; Kondev, F. G.; Kubono, S.; Kurz, N.; Kuti, I.; Lalkovski, S.; Lane, G. J.; Lee, E. J.; Lokotko, T.; Lotay, G.; Moon, C.-B.; Nishibata, H.; Nishizuka, I.; Nita, C. R.; Odahara, A.; Podolyák, Zs.; Roberts, O. J.; Schaffner, H.; Shand, C.; Taprogge, J.; Terashima, S.; Vajta, Z.; Yoshida, S.

    2017-02-01

    The β -decay half-lives of 94 neutron-rich nuclei Cs-151144 , Ba-154146 , La-156148 , Ce-158150 , Pr-160153 , Nd-162156 , Pm-163159 , Sm-166160 , Eu-168161 , Gd-170165 , Tb-172166 , Dy-173169 , Ho-175172 , and two isomeric states Erm174 , Dym172 were measured at the Radioactive Isotope Beam Factory, providing a new experimental basis to test theoretical models. Strikingly large drops of β -decay half-lives are observed at neutron-number N =97 for Ce 58 , Pr 59 , Nd 60 , and Sm 62 , and N =105 for Eu 63 , Gd 64 , Tb 65 , and Dy 66 . Features in the data mirror the interplay between pairing effects and microscopic structure. r -process network calculations performed for a range of mass models and astrophysical conditions show that the 57 half-lives measured for the first time play an important role in shaping the abundance pattern of rare-earth elements in the solar system.

  9. 装备研制过程中知识产权运用分析%Analysis on Applying Intellectual Property in Weapon Equipment R & D Process

    Institute of Scientific and Technical Information of China (English)

    刘宝平; 魏华; 孙胜祥

    2014-01-01

    This paper analyzed the behavioral characteristic and income of stakeholders of weapon equipment R&D process when applying intellectual property.The intellectual property situation was divided into 3 types:buying from other's, using their own and developing new one.The market type is perfect monopoly or oligopoly.It was found that in perfect monopoly market en-terprise has no motivation to apply intellectual property and the military cannot get benefits.In oligopoly market, although makes lose, enterprise will apply intellectual property and military will get benefits.So we should enhance competing and improve the pricing mechanism to improve the application of intellectual property in weapon equipment R&D process.%分析了在完全垄断和寡头垄断两种情况下装备研制企业外购知识产权、运用背景知识产权和开发知识产权时各方的行为特征和收益情况,结果显示:在完全垄断的情况下,企业没有动力运用知识产权,军方不会获得收益;在寡头垄断情况下,企业运用知识产权虽然利益受损,但军方可以从中获益。因此要加强竞争,改进定价机制,促进知识产权有效运用。

  10. A Study on the Evolution Process and Structure Characteristics of Collaboration R & D Network in China in the view of R & D Internationalization%我国协作研发网络的演化过程与结构特征研究--基于R & D国际化视角

    Institute of Scientific and Technical Information of China (English)

    李健

    2013-01-01

    This paper analyses the evolution process and structure characteristics of the collaboration R&D network at regional and individual level. The network is constructed by adopting social network theory and is based on 3752 USPTO patents. The research outcome indicates that degrees of openness and eco-nomic development are two main factors that impact on the region's participation in the collaboration R&D network. Both the frequency and strength of intra-regional and international collaboration R&D activi-ties are higher than of interregional innovation cooperation in China, which implies that absorbed technical knowledge are more likely agglomerated in those developed regions during the R&D internationalization, and the interregional knowledge flow mechanism needs further improvement.%运用社会网络分析法构建了基于3752个专利数据的协作研发网络,重点分析了区域层面的网络演化过程以及发明者层面的网络结构特征。研究结果表明,地区开放程度和经济发展水平是影响区域创新主体参与跨国协作研发活动的潜在因素;发达地区的内部和跨国协作研发活动频率及强度远高于与内陆区域之间的合作创新活动,反映出我国在R&D国际化进程中吸收的技术知识更多地聚集在发达地区,先进知识的跨区域流动机制有待进一步完善。

  11. Processing of red ceramic using a fast-firing cycle Processamento de cerâmica vermelha usando um ciclo de queima rápido

    Directory of Open Access Journals (Sweden)

    G. T. Saleiro

    2012-09-01

    Full Text Available This work reports on the processing of red ceramic for civil construction using fast-firing cycles. The firing cycle is an important variable in the processing of red ceramic materials, which contributes to a high consumption of energy. The red ceramic pieces were prepared by industrial extrusion and fired at firing temperatures varying from 700 ºC to 1100 ºC using different firing cycles (slow-firing cycle - 1º C/min and fast-firing cycle - 10 ºC/min and 20 °C/min. The technological properties (linear shrinkage, water absorption, apparent porosity, apparent density, and flexural strength as function of the firing temperature and firing cycle are investigated. The development of the microstructure was followed by SEM/SEI. The results showed that fast-firing red ceramics exhibits technological properties and microstructure comparable to conventionally fired red ceramics, resulting in great advantages in energy saving.Este trabalho descreve o processamento de cerâmica vermelha para construção civil usando ciclos de queima rápido. O ciclo de queima é uma variável importante no processamento de materiais de cerâmica vermelha, o qual contribui para um alto consumo de energia. As peças de cerâmica vermelha foram preparadas por extrusão industrial e queimadas nas temperaturas de queima variando de 700 ºC a 1100 ºC utilizando diferentes ciclos de queima (ciclo de queima lento - 1 ºC/min e ciclos de queima rápidos - 10 ºC/ min e 20 ºC/min. As propriedades tecnológicas (retração linear, absorção de água, porosidade aparente, massa específica aparente e tensão de ruptura à flexão em função da temperatura de queima e ciclo de queima são investigadas. O desenvolvimento da microestrutura foi avaliado por SEM/SEI. Os resultados mostraram que as peças de cerâmica vermelha obtidas via processo de queima rápida exibiram propriedades tecnológicas e microestrutura comparáveis àquelas convencionalmente obtidas via queima lenta

  12. R graphics

    CERN Document Server

    Murrell, Paul

    2005-01-01

    R is revolutionizing the world of statistical computing. Powerful, flexible, and best of all free, R is now the program of choice for tens of thousands of statisticians. Destined to become an instant classic, R Graphics presents the first complete, authoritative exposition on the R graphical system. Paul Murrell, widely known as the leading expert on R graphics, has developed an in-depth resource that takes nothing for granted and helps both neophyte and seasoned users master the intricacies of R graphics. After an introductory overview of R graphics facilities, the presentation first focuses

  13. Moving-Bed Process for Residue Hydrotreating Procédé à lit mobile pour l'hydrotraitement des résidus

    Directory of Open Access Journals (Sweden)

    Euzen J. P.

    2006-11-01

    the solid particles during the sequential withdrawal. It is the reason why the movement of the solid and, moreover, the residence time distribution of the catalyst particles have been especially followed. To this end, a new technique has been developed to measure the concentration of magnetically marked particles. Furthermore, a specific effort has been devoted to technological problems such as selection and developement of special valves able to insure efficient tightness between the various sections at elevated temperatures and pressures in the presence of solid particles. Another study has been devoted to the operation of addition and withdrawal of the catalyst to and from the reactor running at high pressure and temperature. The solid flows and the catalyst transfer conditions have been carefully studied and tested. Finally a demonstration unit has been built at a semi-industrial scale in a mini-refinery. It was a convincing way to check all the conclusions drawed from the developement step with models, smaller scale pilots and mock-ups. As the fluids and the catalyst were real industrial products, the feasibility of the whole process has been demonstrated. Therefore, a new industrial process using the countercurrent moving bed is now available and permits a very efficient use of the catalyst particles. Un grand nombre de procédés chimiques, pétrochimiques ou de raffinage nécessitent un contact entre 3 phases : un produit de base liquide, un réactif gazeux et un catalyseur solide. Il arrive souvent que l'activité du catalyseur soit réduite par un empoisonnement des sites actifs ou par des dépôts de coke. C'est particulièrement le cas des procédés utilisés dans l'hydrotraitement des résidus lourds. La durée de vie du catalyseur étant réduite, il est nécessaire de remplacer ou de régénérer fréquemment le catalyseur devenu inactif. Différentes solutions permettent d'effectuer ce travail tout en limitant les pertes de temps et de production

  14. GOES-R Space Environment In-Situ Suite: instruments overview, calibration results, and data processing algorithms, and expected on-orbit performance

    Science.gov (United States)

    Galica, G. E.; Dichter, B. K.; Tsui, S.; Golightly, M. J.; Lopate, C.; Connell, J. J.

    2016-05-01

    The space weather instruments (Space Environment In-Situ Suite - SEISS) on the soon to be launched, NOAA GOES-R series spacecraft offer significant space weather measurement performance advances over the previous GOES N-P series instruments. The specifications require that the instruments ensure proper operation under the most stressful high flux conditions corresponding to the largest solar particle event expected during the program, while maintaining high sensitivity at low flux levels. Since the performance of remote sensing instruments is sensitive to local space weather conditions, the SEISS data will be of be of use to a broad community of users. The SEISS suite comprises five individual sensors and a data processing unit: Magnetospheric Particle Sensor-Low (0.03-30 keV electrons and ions), Magnetospheric Particle Sensor-High (0.05-4 MeV electrons, 0.08-12 MeV protons), two Solar And Galactic Proton Sensors (1 to >500 MeV protons), and the Energetic Heavy ion Sensor (10-200 MeV for H, H to Fe with single element resolution). We present comparisons between the enhanced GOES-R instruments and the current GOES space weather measurement capabilities. We provide an overview of the sensor configurations and performance. Results of extensive sensor modeling with GEANT, FLUKA and SIMION are compared with calibration data measured over nearly the entire energy range of the instruments. Combination of the calibration results and model are used to calculate the geometric factors of the various energy channels. The calibrated geometric factors and typical and extreme space weather environments are used to calculate the expected on-orbit performance.

  15. Oxygenated fraction and mass of organic aerosol from direct emission and atmospheric processing measured on the R/V Ronald Brown during TEXAQS/GoMACCS 2006

    Science.gov (United States)

    Russell, L. M.; Takahama, S.; Liu, S.; Hawkins, L. N.; Covert, D. S.; Quinn, P. K.; Bates, T. S.

    2009-04-01

    Submicron particles collected on Teflon filters aboard the R/V Ronald Brown during the Texas Air Quality Study and Gulf of Mexico Atmospheric Composition and Climate Study (TexAQS/GoMACCS) 2006 in and around the port of Houston, Texas, were measured by Fourier transform infrared (FTIR) and X-ray fluorescence for organic functional groups and elemental composition. Organic mass (OM) concentrations (1-25 μg m-3) for ambient particle samples measured by FTIR showed good agreement with measurements made with an aerosol mass spectrometer. The fractions of organic mass identified as alkane and carboxylic acid groups were 47% and 32%, respectively. Three different types of air masses were identified on the basis of the air mass origin and the radon concentration, with significantly higher carboxylic acid group mass fractions in air masses from the north (35%) than the south (29%) or Gulf of Mexico (26%). Positive matrix factorization analysis attributed carboxylic acid fractions of 30-35% to factors with mild or strong correlations (r > 0.5) to elemental signatures of oil combustion and 9-24% to wood smoke, indicating that part of the carboxylic acid fraction of OM was formed by the same sources that controlled the metal emissions, namely the oil and wood combustion activities. The implication is that a substantial part of the measured carboxylic acid contribution was formed independently of traditionally "secondary" processes, which would be affected by atmospheric (both photochemical and meteorological) conditions and other emission sources. The carboxylic acid group fractions in the Gulf of Mexico and south air masses (GAM and SAM, respectively) were largely oil combustion emissions from ships as well as background marine sources, with only limited recent land influences (based on radon concentrations). Alcohol groups accounted for 14% of OM (mostly associated with oil combustion emissions and background sources), and amine groups accounted for 4% of OM in all air

  16. A precision measurement of the Z{sup 0} lineshape parameters for the process Z{sup 0} {r_arrow} {tau}{sup +}{tau}{sup {minus}}

    Energy Technology Data Exchange (ETDEWEB)

    Lahmann, R.

    1996-12-31

    In this dissertation, a measurement of the partial decay width of the process Z{sup 0} {r_arrow} {tau}{sup +}{tau}{sup {minus}} using data collected during 1993 and 1994 at the OPAL detector at CERN is described. The cross sections of this process at three center-of-mass energies near the Z{sup 0} resonance were determined, and from a fit to those cross sections, the mass of the Z{sup 0}, its total decay width and its partial decay width into {tau}{sup +}{tau}{sup {minus}} final states were determined as M{sub Z} = 91.183 {+-} 0.020 GeV, {Lambda}{sub tot} = 2.514 {+-} 0.018 GeV and {Lambda}{sub {tau}{tau}} = 84.54 {+-} 0.59 MeV. Using published results for M{sub Z}, and {Lambda}{sub tot} with higher accuracy, a value for the partial decay width of {Lambda}{sub {tau}{tau}} = 84.02 {+-} 0.20 MeV was obtained. Further using published results for the decay width of the Z{sup 0} into quark pair final states, the invisible decay width of the Z{sup 0} was determined as {Lambda}{sub inv} = 496.9 {+-} 4.1 MeV, and the number of neutrino generations was determined as N{sub {nu}} = 2.974 {+-} 0.025(exp) {+-} 0.007 (m{sub top}, M{sub Higgs}). All results were found to be in good agreement with the Standard Model predictions and were consistent with the assumption of lepton universality within the Standard Model framework.

  17. Twelve Group I introns in the same pre-rRNA transcript of the myxomycete Fuligo septica: RNA processing and evolution.

    Science.gov (United States)

    Lundblad, Eirik W; Einvik, Christer; Rønning, Sissel; Haugli, Kari; Johansen, Steinar

    2004-07-01

    The ribosomal DNA region of the myxomycete Fuligo septica was investigated and found to contain 12 group I introns (four in the small subunit and eight in the large subunit ribosomal RNAs). We have performed molecular and phylogenetic analyses to provide insight into intron structure and function, intron-host biology, and intron origin and evolution. The introns vary in size from 398 to 943 nt, all lacking detectable open reading frames. Secondary structure models revealed considerable structural diversity, but all, except one (subclass IB), represent the common group IC1 intron subclass. In vitro splicing analysis revealed that 10 of the 12 introns were able to self-splice as naked RNA, but all 12 introns were able to splice out from the precursor rRNA in vivo as evaluated by reverse transcription PCR analysis on total F. septica RNA. Furthermore, RNA processing analyses in vitro and in vivo showed that 10 of 12 introns perform hydrolytic cleavage at the 3' splice site, as well as intron circularization. Full-length intron RNA circles were detected in vivo. The order of splicing was analyzed by a reverse transcription PCR approach on cellular RNA, but no strict order of intron excision could be detected. Phylogenetic analysis indicated that most Fuligo introns were distantly related to each other and were independently gained in ribosomal DNA during evolution.

  18. Improved Laboratory Transition Probabilities for Er II and Applications to the Erbium Abundances of the Sun and Five r-Process Rich, Metal-Poor Stars

    CERN Document Server

    Lawler, J E; Cowan, J J; Wyart, J -F; Ivans, I I; Sobeck, J S; Stockett, M H; Hartog, E A Den

    2008-01-01

    Recent radiative lifetime measurements accurate to +/- 5% (Stockett et al. 2007, J. Phys. B 40, 4529) using laser-induced fluorescence (LIF) on 8 even-parity and 62 odd-parity levels of Er II have been combined with new branching fractions measured using a Fourier transform spectrometer (FTS) to determine transition probabilities for 418 lines of Er II. This work moves Er II onto the growing list of rare earth spectra with extensive and accurate modern transition probability measurements using LIF plus FTS data. This improved laboratory data set has been used to determine a new solar photospheric Er abundance, log epsilon = 0.96 +/- 0.03 (sigma = 0.06 from 8 lines), a value in excellent agreement with the recommended meteoric abundance, log epsilon = 0.95 +/- 0.03. Revised Er abundances have also been derived for the r-process-rich metal-poor giant stars CS 22892-052, BD+17 3248, HD 221170, HD 115444, and CS 31082-001. For these five stars the average Er/Eu abundance ratio, = 0.42, is in very good agreement ...

  19. Ptc6 is required for proper rapamycin-induced down-regulation of the genes coding for ribosomal and rRNA processing proteins in S. cerevisiae.

    Directory of Open Access Journals (Sweden)

    Asier González

    Full Text Available Ptc6 is one of the seven components (Ptc1-Ptc7 of the protein phosphatase 2C family in the yeast Saccharomyces cerevisiae. In contrast to other type 2C phosphatases, the cellular role of this isoform is poorly understood. We present here a comprehensive characterization of this gene product. Cells lacking Ptc6 are sensitive to zinc ions, and somewhat tolerant to cell-wall damaging agents and to Li(+. Ptc6 mutants are sensitive to rapamycin, albeit to lesser extent than ptc1 cells. This phenotype is not rescued by overexpression of PTC1 and mutation of ptc6 does not reproduce the characteristic genetic interactions of the ptc1 mutation with components of the TOR pathway, thus suggesting different cellular roles for both isoforms. We show here that the rapamycin-sensitive phenotype of ptc6 cells is unrelated to the reported role of Pt6 in controlling pyruvate dehydrogenase activity. Lack of Ptc6 results in substantial attenuation of the transcriptional response to rapamycin, particularly in the subset of repressed genes encoding ribosomal proteins or involved in rRNA processing. In contrast, repressed genes involved in translation are Ptc6-independent. These effects cannot be attributed to the regulation of the Sch9 kinase, but they could involve modulation of the binding of the Ifh1 co-activator to specific gene promoters.

  20. Measurement of ground state properties of neutron-rich nuclei on the r-process path between the N=50 and N=82 shells

    CERN Multimedia

    2007-01-01

    The evolution of the unknown ground-state ${\\beta}$-decay properties of the neutron-rich $^{84-89}$Ge, $^{90-93}$Se and $^{102-104}$Sr isotopes near the r-process path is of high interest for the study of the abundance peaks around the N=50 and N=82 neutron shells. At ISOLDE, beams of certain elements with sufficient isotopic purity are produced as molecular sidebands rather than atomic beams. This applies e.g, to germanium, separated as GeS$^{+}$, selenium separated as SeCO$^{+}$ and strontium separated as SrF$^{+}$. However, in case of neutron-rich isotopes produced in actinide targets, new "isobaric" background of atomic ions appears on the mass of the molecular sideband. For this particular case, the ECR charge breeder, positioned in the experimental hall after ISOLDE first mass separation, can be advantageously used as a purification device, by breaking the molecules and removing the molecular contaminants. This proposal indicates our interest in the study of basic nuclear structure properties of neutron...

  1. Large scale evaluation of beta-decay rates of r-process nuclei with the inclusion of first-forbidden transitions

    CERN Document Server

    Marketin, T; Martínez-Pinedo, G

    2015-01-01

    R-process nucleosynthesis models rely, by necessity, on nuclear structure models for input. Particularly important are beta-decay half-lives of neutron rich nuclei. At present only a single systematic calculation exists that provides values for all relevant nuclei making it difficult to test the sensitivity of nucleosynthesis models to this input. Additionally, even though there are indications that their contribution may be significant, the impact of first-forbidden transitions on decay rates has not been systematically studied within a consistent model. We use a fully self-consistent covariant density functional theory (CDFT) framework to provide a table of $\\beta$-decay half-lives and $\\beta$-delayed neutron emission probabilities, including first-forbidden transitions. We observe a significant contribution of the first-forbidden transitions to the total decay rate in nuclei far from the valley of stability. The experimental half-lives are in general well reproduced, both for even-even, odd-A and odd-odd n...

  2. A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus

    Directory of Open Access Journals (Sweden)

    Crumpacker Clyde S

    2011-01-01

    Full Text Available Abstract Background The major hurdle in the treatment of Human Immunodeficiency virus type 1 (HIV-1 includes the development of drug resistance-associated mutations in the target regions of the virus. Since reverse transcriptase (RT is essential for HIV-1 replication, several nucleoside analogues have been developed to target RT of the virus. Clinical studies have shown that mutations at RT codon 65 and 74 which are located in β3-β4 linkage group of finger sub-domain of RT are selected during treatment with several RT inhibitors, including didanosine, deoxycytidine, abacavir and tenofovir. Interestingly, the co-selection of K65R and L74V is rare in clinical settings. We have previously shown that K65R and L74V are incompatible and a R→K reversion occurs at codon 65 during replication of the virus. Analysis of the HIV resistance database has revealed that similar to K65R+L74V, the double mutant K65R+L74I is also rare. We sought to compare the impact of L→V versus L→I change at codon 74 in the background of K65R mutation, on the replication of doubly mutant viruses. Methods Proviral clones containing K65R, L74V, L74I, K65R+L74V and K65R+L74I RT mutations were created in pNL4-3 backbone and viruses were produced in 293T cells. Replication efficiencies of all the viruses were compared in peripheral blood mononuclear (PBM cells in the absence of selection pressure. Replication capacity (RC of mutant viruses in relation to wild type was calculated on the basis of antigen p24 production and RT activity, and paired analysis by student t-test was performed among RCs of doubly mutant viruses. Reversion at RT codons 65 and 74 was monitored during replication in PBM cells. In vitro processivity of mutant RTs was measured to analyze the impact of amino acid changes at RT codon 74. Results Replication kinetics plot showed that all of the mutant viruses were attenuated as compared to wild type (WT virus. Although attenuated in comparison to WT virus

  3. Real options value of R&D project:disciplined analysis based on NPD process%R&D项目的期权价值:基于流程的规范化分析

    Institute of Scientific and Technical Information of China (English)

    汤佐群

    2005-01-01

    本文从企业项目层次、在新产品开发流程的基础上阐述了如何把现实期权理论和方法具体运用到企业的R&D决策中来,并运用动态规划的思想和方法就R&D项目中现实期权价值的定量估计问题进行了初步的探索.

  4. A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 acute lymphocytic leukemia cells.

    Science.gov (United States)

    Kotani, Ai; Ha, Daon; Schotte, Diana; den Boer, Monique L; Armstrong, Scott A; Lodish, Harvey F

    2010-03-15

    MLL-AF4 acute lymphocytic leukemia has a poor prognosis, and the mechanisms by which these leukemias develop are not understood despite intensive research based on well-known concepts and methods. MicroRNAs (miRNAs) are a new class of small noncoding RNAs that post-transcriptionally regulate expression of target mRNA transcripts. We recently reported that ectopic expression of miR-128b together with miR-221, two of the miRNAs downregulated in MLL-AF4 ALL, restores glucocorticoid resistance through downregulation of the MLL-AF4 chimeric fusion proteins MLL-AF4 and AF4-MLL that are generated by chromosomal translocation t(4;11). Here we report the identification of new mutations in miR-128b in RS4;11 cells, derived from MLL-AF4 ALL patient. One novel mutation significantly reduces the processing of miR-128b. Finally, this base change occurs in a primary MLL-AF4 ALL sample as an acquired mutation. These results demonstrate that the novel mutation in miR-128b in MLL-AF4 ALL alters the processing of miR-128b and that the resultant downregulation of mature miR-128b contributes to glucocorticoid resistance through the failure to downregulate the fusion oncogenes.

  5. Introducing the Fission-Fusion Reaction Process: Using a Laser-Accelerated Th Beam to produce Neutron-Rich Nuclei towards the N=126 Waiting Point of the r Process

    CERN Document Server

    Habs, D; Gross, M; Allinger, K; Bin, J; Henig, A; Kiefer, D; Ma, W; Schreiber, J

    2010-01-01

    We propose to produce neutron-rich nuclei in the range of the astrophysical r process around the waiting point N=126 by fissioning a dense laser-accelerated thorium ion bunch in a thorium target (covered by a polyethylene layer), where the light fission fragments of the beam fuse with the light fission fragments of the target. Via laser Radiation Pressure Acceleration using a high-intensity, short pulse laser, very efficiently bunches of solid state density of 232Th can be generated from a first Th production target, placed on a CH2 backing. Laser accelerated Th ions with about 7 MeV/u will pass through a thin polyethylene layer placed in front of a thicker second Th foil closely behind the first target and desintegrate into light and heavy fission fragments. In addition light ions (p,C) from the CH2 backing of the first Th target will be accelerated as well, inducing the fission process of 232Th also in the second Th target. The laser-accelerated ion bunches with solid state density, which are about 10^15 ti...

  6. Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiae.

    Science.gov (United States)

    Faber, Alex W; Van Dijk, Marie; Raué, Hendrik A; Vos, Jan C

    2002-09-01

    Saccharomyces cerevisiae contains three nonessential genes (NGL1, NGL2, and NGL3) that encode proteins containing a domain with similarity to a Mg(2+)-dependent endonuclease motif present in the mRNA deadenylase Ccr4p. We have investigated a possible role of these proteins in rRNA processing, because for many of the pre-rRNA processing steps, the identity of the responsible nuclease remains elusive. Analysis of RNA isolated from cells in which the NGL2 gene has been inactivated (ngl2delta) demonstrates that correct 3'-end formation of 5.8S rRNA at site E is strictly dependent on Ngl2p. No role in pre-rRNA processing could be assigned to Ngl1p and Ngl3p. The 3'-extended 5.8S rRNA formed in the ngl2delta mutant is slightly shorter than the 6S precursor previously shown to accumulate upon combined deletion of the 3' --> 5' exonuclease-encoding REX1 and REX2 genes or upon depletion of the exosomal subunits Rrp40p or Rrp45p. Thus, our data add a further component to the set of nucleases required for correct 3'-end formation of yeast 5.8S rRNA.

  7. Developing a closed-form cost expression for an (R, s, nQ) policy where the demand process is compound generalized Erlang

    DEFF Research Database (Denmark)

    Larsen, Christian; Kiesmüller, G.P

    2007-01-01

    We derive a closed-form cost expression for an (R,s,nQ) inventory control policy where all replenishment orders have a constant lead-time, unfilled demand is back-logged and inter-arrival times of order requests are generalized Erlang distributed. For given values of Q and R we show how to compute...

  8. Developing a closed-form cost expression for an (R, s, nQ) policy where the demand process is compound generalized Erlang

    DEFF Research Database (Denmark)

    Larsen, Christian; Kiesmüller, G.P

    2007-01-01

    We derive a closed-form cost expression for an (R,s,nQ) inventory control policy where all replenishment orders have a constant lead-time, unfilled demand is back-logged and inter-arrival times of order requests are generalized Erlang distributed. For given values of Q and R we show how to compute...

  9. Silica Hybrid Containing ( R )-2, 2'-Binaphtho-20-crown-6 Moieties via the Sol-Gel Process

    Institute of Scientific and Technical Information of China (English)

    成义祥; 刘田东; 陈令武

    2003-01-01

    (R)-6,6'-Bis(triethoxysilylethen-2-yl)-2,2-'binaphtho-20-crown-6(precursor,R-2) derived form(R)-2,2-BINOL derivative was synthesized by Pd-catelyzed Heck reaction of (R)-6-6'-dibromo-2,2'-binaphtoh-20-crown-6(R-1) intermediate with vinyltriethoxysilane. The hydrolysis and polycondensatlon ofthe precursor gave rise to the corresponding xerogei. Both pre cursor and xerogei were analysed by NMR, FT-IR, UV, CD spectra, fluorescent spectroscopy, polarimetry and elemental analysis. The precursor and xerogei can emit strong blue fluorescenee and are expected to have the potential appficatiou inthe separation of chiral molecules as fluorescent sensor. The precursor exhibits strong Cotton effect in its circular dichroism (CD) spectrum indicating that it is a highly rigid structure.

  10. Jets with Variable R

    CERN Document Server

    Krohn, David; Wang, Lian-Tao

    2009-01-01

    We introduce a new class of jet algorithms designed to return conical jets with a variable Delta R radius. A specific example, in which Delta R scales as 1/pT, proves particularly useful in capturing the kinematic features of a wide variety of hard scattering processes. We implement this Delta R scaling in a sequential recombination algorithm and test it by reconstructing resonance masses and kinematic endpoints. These test cases show 10-20% improvements in signal efficiency compared to fixed Delta R algorithms. We also comment on cuts useful in reducing continuum jet backgrounds.

  11. Characteristics of a-GaN films and a-AlGaN/GaN heterojunctions prepared on r-sapphire by two-stage growth process

    Science.gov (United States)

    Polyakov, A. Y.; Jang, Lee-Woon; Smirnov, N. B.; Govorkov, A. V.; Kozhukhova, E. A.; Yugova, T. G.; Reznik, V. Y.; Pearton, S. J.; Baik, Kwang Hyeon; Hwang, Sung-Min; Jung, Sukkoo; Lee, In-Hwan

    2011-11-01

    The electrical properties, presence of deep electron and hole traps and photoluminescence spectra were measured for undoped a-GaN films grown by metal-organic chemical vapor deposition (MOCVD) in a two-stage process using a high V/III ratio at the first stage and low V/III ratio at the second stage. Growth was performed on r-sapphire substrates with a high temperature GaN nucleation layer. The films showed a full width at half maximum of 450-470 arcseconds for the (11-20) x-ray rocking curve with little anisotropy with respect to the sample rotation around the growth direction. The stacking fault (SF) density determined by selective etching was ˜5 × 104 cm-1. The residual donor concentration was 1014-1015 cm-3, with a very low density (2.5 × 1013 cm-3) of electron traps located at Ec - 0.6 eV, which are believed to be one of the major non-radiative recombination centers in nonpolar GaN. Consequently, the films showed a high intensity of bandedge luminescence with negligible contribution from defect bands associated with SFs. In contrast to previously studied nonpolar GaN films, the a-GaN layers showed a high concentration of gallium-vacancy-related acceptors near Ev + 1 eV and a strong yellow luminescence band, both indicating that growth conditions were effectively N-rich. a-AlGaN/GaN heterojunctions with thin heavily Si doped AlGaN barriers made on a-GaN substrates showed two-dimensional electron gas (2DEG) concentrations of 1.2 × 1013 cm-3, with 2DEG mobility of 80 cm2/Vs. Capacitance-voltage profiling of Schottky diodes on these HJs suggest that the 2DEG is fully depleted by the built-in voltage of the Schottky diode.

  12. Thermophysical properties of {l_brace}({+-})-linalool + propan-1-ol{r_brace}: A first stage towards the development of a green process

    Energy Technology Data Exchange (ETDEWEB)

    Garcia-Abarrio, Sandra M.; Torcal, Marcos; Haya, M. Luisa; Urieta, Jose S. [Group of Applied Thermodynamics and Surfaces (GATHERS), Aragon Institute for Engineering Research (I3A), Universidad de Zaragoza, Facultad de Ciencias, Zaragoza 50009 (Spain); Mainar, Ana M., E-mail: ammainar@unizar.e [Group of Applied Thermodynamics and Surfaces (GATHERS), Aragon Institute for Engineering Research (I3A), Universidad de Zaragoza, Facultad de Ciencias, Zaragoza 50009 (Spain)

    2011-04-15

    Research highlights: Optimization of supercritical processes needs adequate methods to reproduce the phase behavior. {rho}, u, n{sub D} and related properties of the system linalool+propan-1-ol were studied. Collision Factor (u), Lorentz-Lorenz and Gladstone -Dale (n{sub D}) give the best results. Peng-Robinson, Patel-Teja, SAFT and PC-SAFT were tested as predictive P{rho}T models. PC-SAFT provides the best P{rho}T prediction (20-40 MPa) with an AAD% of 0.83. - Abstract: In this paper, densities, speeds of sound and refractive indexes of binary mixture of {l_brace}({+-})-linalool (1) + propan-1-ol (2){r_brace} at four temperatures (283.15, 298.15, 313.15, and 328.15) K and 0.1 MPa are reported over the whole composition range. These data were used to calculate excess molar volume, speed of sound deviation, excess isentropic compressibility, refractive index deviation, molar refraction, and molar refraction deviation at the four work temperatures. All magnitudes were fitted to the Redlich-Kister equation. Subsequently prediction of speed of sound and refractive index was carried out using several theoretical models or equations. On the other hand, the density of the same mixture was determined in the same temperature range at pressures from 20 MPa to 40 MPa. Four equation of state (Peng-Robinson, Patel-Teja, SAFT, PC-SAFT) were tested as predictive models of the P{rho}T behavior. The best results were obtained by PC-SAFT, with an average absolute deviation of 0.83%.

  13. Enzymatic degradation processes of lamellar crystals in thin films for poly[(R)-3-hydroxybutyric acid] and its copolymers revealed by real-time atomic force microscopy.

    Science.gov (United States)

    Numata, Keiji; Hirota, Takuya; Kikkawa, Yoshihiro; Tsuge, Takeharu; Iwata, Tadahisa; Abe, Hideki; Doi, Yoshiharu

    2004-01-01

    Enzymatic degradation processes of flat-on lamellar crystals in melt-crystallized thin films of poly[(R)-3-hydroxybutyric acid] (P(3HB)) and its copolymers were characterized by real-time atomic force microscopy (AFM) in a phosphate buffer solution containing PHB depolymerase from Ralstonia pickettii T1. Fiberlike crystals with regular intervals were generated along the crystallographic a axis at the end of lamellar crystals during the enzymatic degradation. The morphologies and sizes of the fiberlike crystals were markedly dependent on the compositions of comonomer units in the polyesters. Length, width, interval, and thickness of the fiberlike crystals after the enzymatic degradation for 2 h were measured by AFM, and the dimensions were related to the solid-state structures of P(3HB) and its copolymers. The width and thickness decreased at the tip of fiberlike crystals, indicating that the enzymatic degradation of crystals takes place not only along the a axis but also along the b and c axes. These results from AFM measurement were compared with the data on crystal size by wide-angle X-ray diffraction, and on lamellar thickness and long period by small-angle X-ray scattering. In addition, the enzymatic erosion rate of flat-on lamellar crystals along the a axis was measured from real-time AFM height images. A schematic glacier model for the enzymatic degradation of flat-on lamellar crystals of P(3HB) by PHB depolymerase has been proposed on the basis of the AFM observations.

  14. Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiae.

    OpenAIRE

    Faber, Alex W.; van Dijk, Marie; Raué, Hendrik A.; Vos, Jan C.

    2002-01-01

    Saccharomyces cerevisiae contains three nonessential genes (NGL1, NGL2, and NGL3) that encode proteins containing a domain with similarity to a Mg(2+)-dependent endonuclease motif present in the mRNA deadenylase Ccr4p. We have investigated a possible role of these proteins in rRNA processing, because for many of the pre-rRNA processing steps, the identity of the responsible nuclease remains elusive. Analysis of RNA isolated from cells in which the NGL2 gene has been inactivated (ngl2delta) de...

  15. Parallel R

    CERN Document Server

    McCallum, Ethan

    2011-01-01

    It's tough to argue with R as a high-quality, cross-platform, open source statistical software product-unless you're in the business of crunching Big Data. This concise book introduces you to several strategies for using R to analyze large datasets. You'll learn the basics of Snow, Multicore, Parallel, and some Hadoop-related tools, including how to find them, how to use them, when they work well, and when they don't. With these packages, you can overcome R's single-threaded nature by spreading work across multiple CPUs, or offloading work to multiple machines to address R's memory barrier.

  16. Non-Canonical Processing of Arabidopsis pri-miR319a/b/c Generates Additional microRNAs to Target One RAP2.12 mRNA Isoform.

    Science.gov (United States)

    Sobkowiak, Lukasz; Karlowski, Wojciech; Jarmolowski, Artur; Szweykowska-Kulinska, Zofia

    2012-01-01

    Arabidopsis miR319a/b/c primary transcripts are unusual due to the presence of a long stem and loop structure containing functional miR319a/b/c molecules. In our experiments carried out using high throughput sequencing (HTS), we have shown that additional microRNAs (miRNAs), miR319a.2/b.2/c.2 are generated from the upper part of the same hairpin structure. We have also found cognate miRNAa.2*/b.2*/c.2* to be present in the HTS results with a considerably lower number of reads. Northern hybridization revealed that miR319b.2 is mainly expressed in 35-day-old plant rosette leaves, as well as in stem and inflorescences of 42- and 53-day-old plants. Moreover, it carries multiple signatures of a functional miRNA, including as follows: (i) its biogenesis is HYL1-dependent; (ii) it is incorporated in a substantial amount into RISC complexes containing AGO1, AGO2, or AGO4 protein; (iii) 24 nt-long species of miR319b.2 have been found in inflorescences to be more abundant than 21 nt miR319b.2 species; (iv) it is present in various ratios to miR319b during plant development, which suggests the existence of a regulatory mechanism responsible for its biogenesis/processing; (v) there is an observed cross-species conservation of the miR319a/b/c stem nucleotide sequence extending beyond mature miRNA region; and (vi) all evidence suggests that intron-containing RAP2.12 mRNA isoform is the target for miR319b.2. All these features prompt us to claim miR319b.2 as a functional miRNA molecule.

  17. R + R$^{2}$ gravity as R + backreaction

    CERN Document Server

    Kung, J H

    1995-01-01

    Quadratic theory of gravity is a complicated constraint system. We investigate some consequences of treating quadratic terms perturbatively (higher derivative version of backreaction effects). This approach is shown to overcome some well known problems associated with higher derivative theories, i.e., the physical gravitational degree of freedom remains unchanged from those of Einstein gravity. Using such an interpretation of R + \\beta R^2 gravity, we investigate a classical and Wheeler DeWitt evolution of R + \\beta R^2 gravity for a particular sign of \\beta, corresponding to non- tachyon case. Matter is described by a phenomenological \\rho \\propto a(t)^{-n}. It is concluded that both the Friedmann potential U(a) ( {\\dot a}^2 + 2U(a) = 0 ) and the Wheeler DeWitt potential W(a) (\\left[-{\\partial^2\\over \\partial a^2} + 2W(a)\\right]\\psi (a) =0 ) develop repulsive barriers near a\\approx 0 for n>4 (i.e., p > {1\\over 3}\\rho ). The interpretations is clear. Repulsive barrier in U(a) implies that a contracting FRW un...

  18. Outsourcing R&D

    DEFF Research Database (Denmark)

    Hsuan, Juliana; Mahnke, Volker

    2011-01-01

    Outsourcing R&D is an increasingly explored corporate practice. Extant research advanced our initial understanding of its increasing importance and benefits. While the associated literature has blossomed, the enthusiasm of R&D managers is tenured by an increasing realization of the possible...... downsides, risks, and costs that come with increasing use of external sources of innovation. Here, we suggest that research on outsourcing R&D has to move towards a balanced view on the profitability of such arrangements. To this end, we offer a review of what we know and need to know about outsourcing R......&D, suggest a simple, yet integrative model on the relation between outsourcing R&D and performance, and offer a research agenda that is instrumental in guiding companies’ process-management and design strategies when seeking to benefit from the outsourcing of R&D....

  19. Outsourcing R&D

    DEFF Research Database (Denmark)

    Hsuan, Juliana; Mahnke, Volker

    2011-01-01

    Outsourcing R&D is an increasingly explored corporate practice. Extant research advanced our initial understanding of its increasing importance and benefits. While the associated literature has blossomed, the enthusiasm of R&D managers is tenured by an increasing realization of the possible...... downsides, risks, and costs that come with increasing use of external sources of innovation. Here, we suggest that research on outsourcing R&D has to move towards a balanced view on the profitability of such arrangements. To this end, we offer a review of what we know and need to know about outsourcing R......&D, suggest a simple, yet integrative model on the relation between outsourcing R&D and performance, and offer a research agenda that is instrumental in guiding companies’ process-management and design strategies when seeking to benefit from the outsourcing of R&D....

  20. A DFT Study of R-X Bond Dissociation Enthalpies of Relevance to the Initiation Process of Atom Transfer Radical Polymerization

    DEFF Research Database (Denmark)

    Gillies, Malcolm Bjørn; Matyjaszewski, Krzysztof; Norrby, Per-Ola

    2003-01-01

    DFT calculations at the B3P86/6-31G** level have been carried out to derive the bond dissociation energies (BDE) and free energies for a number of R-X systems (X ) Cl, Br, I, N3, and S2-CNMe2) that have been or can potentially be used as initiators for atom transfer radical polymerization (ATRP......). For selected systems, a conformational search was carried out for R-X and R by using semiempirical (PM3) and molecular mechanics (MM+ augmented with appropriately optimized parameters for the radical systems) methods. The MM+ technique is more suited to search for the most stable conformations. The computed...

  1. Analysis of New Variety and Technology of Copper Clad Laminates Worldwide(Ⅶ)——Low CTE High Reliability Good Processability PCB Substrate Material R-1755V from Panasonic Electric Works%世界覆铜板新产品新技术赏析(Ⅶ)——松下电工低CTE高可靠良好加工性R-1755V

    Institute of Scientific and Technical Information of China (English)

    张家亮

    2009-01-01

    文章介绍了松下电工PCB基板材料的发展战略,综述了R-1755V的诸多性能,R-1755V具有低热膨胀、高可靠性和良好加工性,应用于网络设备、测量仪器和汽车领域.%In the paper, development stratagem of PCB substrate material of Matsushita Electric Works, Ltd. was introduced a great deal of performance included low coefficient of thermal expansion, high reliability, good PCB process of R-1755V were reviewed. R-1755V is used in network equipment, measuring instruments and automotive.

  2. 基于竞合视角的产学R&D联盟发展过程的影响因素研究%Research on the Influencing Factors of the Developing Process of Collaborative R&D Union of Industry-University Based on the Co-opetition Perspective

    Institute of Scientific and Technical Information of China (English)

    黄攸立; 王茜; 洪嵩

    2013-01-01

    竞合理论认为价值创造的本质是合作,价值分配的本质是竞争.产学R&D联盟的发展是双方共同投入人力资金创造价值,共同分享R&D成果分配价值的过程,即大学、产业两个彼此独立的实体为创造价值而合作,同时为了自身利益最大化而竞争,这种竞合关系存在于联盟过程的始终.当前学者们尚未从竞合角度对产学R&D联盟进行分析,因此,本文通过梳理相关国内外文献,从竞合的视角分析产学R&D联盟发展中的各种影响因素,并构建其路径发展模型.%Based on co-opetition theory, cooperation is considered as the essence of value creation, and competition is the essence of value distribution. In the development of collaborative R&D unit of Industry-University, they input resource to create value and share the R&D achievement to distribute value, namely, they cooperate for creating the value and compete for maximizing the benefit, and the co-opetition relationship will exist in the union from beginning to the end. However, there is no scholar analysis on R&D union of Industry-University from co-opetition perspective. In this paper, after reviewing the related literatures, we analyzed the influencing factors of the Industry-University R&D union during the process of developing based on the co-opetition assumption, and then established the model for this process.

  3. (R-Doxylaminium (R,R-tartrate

    Directory of Open Access Journals (Sweden)

    A.S. Dayananda

    2012-04-01

    Full Text Available In the title compound (systematic name: (R-dimethyl{2-[1-phenyl-1-(pyridin-2-ylethoxy]ethyl}azanium (R,R-3-carboxy-2,3-dihydroxypropanoate, C17H23N2O+·C4H5O6−, the doxylaminium cation is protonated at the N atom. The tartrate monoanions are linked by short, almost linear O—H...O hydrogen bonds into chains extended along [100]. These chains are interlinked by anion–pyridine O—H...N hydrogen bonds into a two-dimensional grid structure. WeakC—H...O interactions also play a role in the crystal packing. An intramolecular hydroxy–carboxylate O—H...O hydrogen bond influences the conformation of the anion: the hydrogen-bonded fragment is almost planar, the maximum deviation from the mean plane being 0.059 (14 Å. In the cation, the aromatic rings are almost perpendicular [dihedral angle = 84.94 (8°] and the conformation of the O—C—C—N chain is gauche(−, the dihedral angle is −76.6 (2°. The absolute configuration was assigned on the basis of known chirality of the parent compound.

  4. Materials specification VGB-R 109 and processing standards. First experiences of a large-scaled power plant for quality control purposes

    Energy Technology Data Exchange (ETDEWEB)

    Bareiss, J.; Nothdurft, R.; Kurtz, M. [EnBW Kraftwerke AG, Stuttgart (Germany); Helmrich, A.; Hartwig, R. [Alstom Power Systems GmbH, Stuttgart (Germany); Bantle, M. [TUEV SUED Industrie Service GmbH, Filderstadt (Germany)

    2009-07-01

    New boilers in Europe shall be manufactured by the Manufacturer as contractor of the Customer based on PED (European Pressure Equipment Directive 97/23/EC), applicable as legal Directive since May 2002. According PED, the Manufacturer is equivalent to a legal person, responsible for calculation, design, fabrication at workshop and site, including final inspection and declaration of conformity, independent if work packages are subcontracted by Manufacturer or not. Based on Customer contract, Module G shall be used as process to prove conformity according PED. As principle, PED specifies fundamental safety requirements with main focus for materials, and fabrication. For 600 C / 620 C power plants with advanced steam conditions and considerably improving efficiency, new materials are necessary. For selection of the materials, attention has to be paid to the long term design strength values, the manufacturability of the materials as well as the corrosion and oxidation behaviour. Particularly the correct fabrication according to the state of the art closely linked to new discoveries about material behaviour for semi-finished products as well as for boiler components has to be ensured. These new materials are mainly not covered by PED respectively the harmonized standard EN 12952. For that reason and Customer contract with view on national legal directives which specifies the period of in-service inspection during the operational lifetime of the boiler, additional codes and standards shall be applied for boiler manufacturing. All these requirements shall be specified in the Quality Engineering Documents of Manufacturer. The presentation gives an overview of fundamentals of PED and describes the implementation of the requirements for materials, fabrication and inspections in the Quality Engineering Documents, both in the framework of PED and Customer contract. As part of Design Approval by NoBo according PED Module G, the Quality Engineering Documents are fundamental

  5. Mathematical modeling of fluid flow and thermal analysis in ladle of R H degasser process; Modelamento matematico do escoamento e analise termica na panela do processo de desgaseificacao a vacuo do tipo RH

    Energy Technology Data Exchange (ETDEWEB)

    Cerqueira, Osvane L.; Silva, Alexandre J. da; Costa e Silva, Andre L.V. da [Universidade Federal Fluminense (UFF), Volta Redonda, RJ (Brazil). Escola de Engenharia Industrial Metalurgica

    1996-12-31

    This work presents a numerical analysis of the fluid flow and thermal analysis in the ladle of R H vacuum degassing process. As a result of this analysis, a better understanding of the fluid flow patterns and of the turbulence regions inside the ladle. (author) 4 refs., 7 figs., 3 tabs.

  6. Procédé de suralcalinisation d'additifs détergents : rôle des promoteurs et détermination du régime de la réaction de surbasage Overbasing Process of Detergent Additives: Behavior of Promoters and Determination of Factors Controling the Reaction

    Directory of Open Access Journals (Sweden)

    Gallo R.

    2006-11-01

    Full Text Available Le mécanisme du procédé de suralcalinisation des huiles lubrifiantes est étudié. L'analyse du contrôle physique et (ou chimique est effectué dans ce procédé polyphasique, où une base solide (chaux, magnésie en suspension dans une solution, constituée d'une microémulsion, est carbonatée. Le carbonate non colloïdal est formé dans le milieu par une réaction successive à celle de la formation de carbonate colloïdal. La réaction, en présence (et en absence de détergent alkylarylsulfonique, n'est pas limitée par la cinétique chimique, mais par la diffusion des réactifs. Le méthanol, utilisé comme cotensioactif, influe sur la quantité de carbonate colloïdal sans augmenter la vitesse de surbasage. Les essais en milieu anhydre montrent que la présence d'une quantité très faible d'eau est indispensable. L'importance de la dilution par le solvant (xylène et la réactivité comparée MgO/Ca(OH2 sont discutées. Overbased (overalcalinized detergent additives are applied in lubrication of modern combustion engines : they neutralize the acidic products coming from combustion and fight corrosive wear. Overbased calcium sulfonates, the most widely used are made by carbonating CaO or Ca(OH2 in an hydrocarbon mixture (alkane + xylene containing a detergent (mostly alkylaryl-sulfonate and reaction promoters (water, alcohol, amine. The process is operated by several companies and a large amount of patent literature is reported on the subject [2]; however if the geometrical and physical nature of the colloidal carbonare particles formed in the process has been studied, very little is known on the fundamental aspects and on the mechanism of the overbasing process; this is what is described and discussed in this paper. Following previous kinetic results on experimental parameters associated to carbonatation, [4], further data are obtained applying kinetic graphs used in reactor analysis of complex reactions (Fig. 1. Plotting YA

  7. Termoestabilidade de processos extrativos de Nasturtium officinale R. Br., brassicaceae por sistema Soxhlet modificado Term-stability of extractive processes from Nasturtium officinale R. Br., brassicaceae for soxhlet modified system

    Directory of Open Access Journals (Sweden)

    João Luiz de Souza Carvalho

    2009-01-01

    Full Text Available This work had as objective verified the term-stability of the Soxhlet modified system with analytical and pharmacothecnical application in extractive processes of Nasturtium officinale. It has proven that the process is thermo-stable. The analysis with analytical have determined 3.606 mg g-1 in chlorogenic acid and 11.813 mg g-1 in rutin (extract 1:20 w/v and with pharmacotecnical 3.427 mg g-1 in chlorogenic acid and 11.278 mg g-1 in rutin (extract 1:6 w/v. The income of the pharmacothecnical process was inferior to the analytical, suggesting that the pharmacothecnical process would need of at least the double of time in each extraction system.

  8. Developing a closed-form cost expression for an (R,s,nQ) policy where the demand process is compound generalized Erlang

    DEFF Research Database (Denmark)

    Larsen, Christian; Kiesmüller, Gudrun P.

    We derive a closed-form cost expression for an (R,s,nQ) inventory control policy where all replenishment orders have a constant lead-time, unfilled demand is backlogged and inter-arrival times of order requests are generalized Erlang distributed.......We derive a closed-form cost expression for an (R,s,nQ) inventory control policy where all replenishment orders have a constant lead-time, unfilled demand is backlogged and inter-arrival times of order requests are generalized Erlang distributed....

  9. A Simple Expression for the Matrix Gradient of a Diagonal Element of R in QR Decomposition for Use in MIMO Communications and Signal Processing

    Science.gov (United States)

    2010-12-01

    est bien connu que n’importe quelle matrice A peut être décomposée, ou factorisée, puisque A = QR où Q est une matrice à colonnes ortho- normales...signal plus bruit A, il est intéressant de connaı̂tre les effets du bruit surQ etR . À cette fin, les gradients des élémentsQ etR par rapport àA

  10. SOT1, a pentatricopeptide repeat protein with a small MutS-related domain, is required for correct processing of plastid 23S-4.5S rRNA precursors in Arabidopsis thaliana.

    Science.gov (United States)

    Wu, Wenjuan; Liu, Sheng; Ruwe, Hannes; Zhang, Delin; Melonek, Joanna; Zhu, Yajuan; Hu, Xupeng; Gusewski, Sandra; Yin, Ping; Small, Ian D; Howell, Katharine A; Huang, Jirong

    2016-03-01

    Ribosomal RNA processing is essential for plastid ribosome biogenesis, but is still poorly understood in higher plants. Here, we show that SUPPRESSOR OF THYLAKOID FORMATION1 (SOT1), a plastid-localized pentatricopeptide repeat (PPR) protein with a small MutS-related domain, is required for maturation of the 23S-4.5S rRNA dicistron. Loss of SOT1 function leads to slower chloroplast development, suppression of leaf variegation, and abnormal 23S and 4.5S processing. Predictions based on the PPR motif sequences identified the 5' end of the 23S-4.5S rRNA dicistronic precursor as a putative SOT1 binding site. This was confirmed by electrophoretic mobility shift assay, and by loss of the abundant small RNA 'footprint' associated with this site in sot1 mutants. We found that more than half of the 23S-4.5S rRNA dicistrons in sot1 mutants contain eroded and/or unprocessed 5' and 3' ends, and that the endonucleolytic cleavage product normally released from the 5' end of the precursor is absent in a sot1 null mutant. We postulate that SOT1 binding protects the 5' extremity of the 23S-4.5S rRNA dicistron from exonucleolytic attack, and favours formation of the RNA structure that allows endonucleolytic processing of its 5' and 3' ends. © 2016 The Authors The Plant Journal © 2016 John Wiley & Sons Ltd.

  11. EfaR Is a Major Regulator of Enterococcus faecalis Manganese Transporters and Influences Processes Involved in Host Colonization and Infection

    NARCIS (Netherlands)

    Abrantes, M. C.; Kok, J.; Lopes, M. de F.

    2013-01-01

    Metal ions, in particular manganese, are important modulators of bacterial pathogenicity. However, little is known about the role of manganese-dependent proteins in the nosocomial pathogen Enterococcus faecalis, a major cause of bacterial endocarditis. The present study demonstrates that the DtxR/Mn

  12. rAAV-mediated overexpression of sox9, TGF-β and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair.

    Science.gov (United States)

    Frisch, J; Rey-Rico, A; Venkatesan, J K; Schmitt, G; Madry, H; Cucchiarini, M

    2016-03-01

    Administration of therapeutic gene sequences coding for chondrogenic and chondroreparative factors in bone marrow aspirates using the clinically adapted recombinant adeno-associated virus (rAAV) vector may provide convenient, single-step approaches to improve cartilage repair. Here, we tested the ability of distinct rAAV constructs coding for the potent SOX9, transforming growth factor beta (TGF-β) and insulin-like growth factor I (IGF-I) candidate factors to modify marrow aspirates from minipigs to offer a preclinical large animal model system adapted for a translational evaluation of cartilage repair upon transplantation in sites of injury. Our results demonstrate that high, prolonged rAAV gene transfer efficiencies were achieved in the aspirates (up to 100% for at least 21 days) allowing to produce elevated amounts of the transcription factor SOX9 that led to increased levels of matrix synthesis and chondrogenic differentiation and of the growth factors TGF-β and IGF-I that both increased cell proliferation, matrix synthesis and chondrogenic differentiation (although to a lower level than SOX9) compared with control (lacZ) condition. Remarkably, application of the candidate SOX9 vector also led to reduced levels of hypertrophic differentiation in the aspirates, possibly by modulating the β-catenin, Indian hedgehog and PTHrP pathways. The present findings show the benefits of modifying minipig marrow concentrates via rAAV gene transfer as a future means to develop practical strategies to promote cartilage repair in a large animal model.

  13. Machine learning with R

    CERN Document Server

    Lantz, Brett

    2013-01-01

    Written as a tutorial to explore and understand the power of R for machine learning. This practical guide that covers all of the need to know topics in a very systematic way. For each machine learning approach, each step in the process is detailed, from preparing the data for analysis to evaluating the results. These steps will build the knowledge you need to apply them to your own data science tasks.Intended for those who want to learn how to use R's machine learning capabilities and gain insight from your data. Perhaps you already know a bit about machine learning, but have never used R; or

  14. The R primer

    CERN Document Server

    Ekstrom, Claus Thorn

    2011-01-01

    Newcomers to R are often intimidated by the command-line interface, the vast number of functions and packages, or the processes of importing data and performing a simple statistical analysis. The R Primer provides a collection of concise examples and solutions to R problems frequently encountered by new users of this statistical software.Rather than explore the many options available for every command as well as the ever-increasing number of packages, the book focuses on the basics of data preparation and analysis and gives examples that can be used as a starting point. The numerous examples i

  15. At R407/R408

    CERN Multimedia

    1974-01-01

    R407/R408 were experiments designed by the CERN-Collège de France-Heidelberg-Karlsruhe Collaboration to study two-particle correlations in the fragmentation region requiring a large transverse momentum particle in the forward direction. Atmospheric pressure Cerenkov counters were part of the additional equipment set up during 1974 at the SFM facility. Here Paul Hanke multi-reflected on Cerenkov mirrors.

  16. "龙腾R"微处理器分支处理单元的研究与设计%Research and Design of Branch Process Unit in "Longtium R" Microprocessor

    Institute of Scientific and Technical Information of China (English)

    鄢国丰; 张盛兵; 黄小平

    2010-01-01

    "龙腾R"是西北工业大学自主研制的32位高性能微处理器.该处理器的分支处理单元(BPU)能有效降低控制相关带来的延迟.通过分析已有的分支方向预测算法和分支目标地址预测策略,在分支处理单元总体约束下,合理分配分支方向预测和目标地址预测的实现代价,提出了一种基于混合分支预测器和经过改进的目标地址缓冲(grB)结构的分支处理单元结构.该结构不仅比传统的由gshare分支方向预测器构成的分支处理单元预测准确率平均高出1%~2%,并具有面积小、功耗低的特点.

  17. S2P3-R (v1.0: a framework for efficient regional modelling of physical and biological structures and processes in shelf seas

    Directory of Open Access Journals (Sweden)

    R. Marsh

    2015-01-01

    Full Text Available An established 1-dimensional model of Shelf Sea Physics and Primary Production (S2P3 is adapted for regional use in realistic geographical domains over selected years, for selected regions. The S2P3-R framework (v1.0 can be used to efficiently map 3-D physical and biological structures in shelf seas, in particular the tidal mixing fronts that seasonally develop at boundaries between mixed and stratified water. The model has primarily been developed for undergraduate oceanography modules and research projects, providing a practical tool for linking theory and field observations, but it is also useful as an investigative research tool alongside more complex and computationally expensive models. Four different configurations of S2P3-R are described and evaluated, illustrating a range of diagnostics, evaluated where practical with available observations. The model can be forced with daily meteorological variables for any selected year in the reanalysis era (1948 onwards. Example simulations illustrate the considerable extent of synoptic-to-interannual variability in the physics and biology of shelf seas. In discussion, the present limitations of S2P3-R are emphasized, and future model developments are outlined.

  18. The 28S-18S rDNA intergenic spacer from Crithidia fasciculata: repeated sequences, length heterogeneity, putative processing sites and potential interactions between U3 small nucleolar RNA and the ribosomal RNA precursor.

    Science.gov (United States)

    Schnare, M N; Collings, J C; Spencer, D F; Gray, M W

    2000-09-15

    In Crithidia fasciculata, the ribosomal RNA (rRNA) gene repeats range in size from approximately 11 to 12 kb. This length heterogeneity is localized to a region of the intergenic spacer (IGS) that contains tandemly repeated copies of a 19mer sequence. The IGS also contains four copies of an approximately 55 nt repeat that has an internal inverted repeat and is also present in the IGS of Leishmania species. We have mapped the C.fasciculata transcription initiation site as well as two other reverse transcriptase stop sites that may be analogous to the A0 and A' pre-rRNA processing sites within the 5' external transcribed spacer (ETS) of other eukaryotes. Features that could influence processing at these sites include two stretches of conserved primary sequence and three secondary structure elements present in the 5' ETS. We also characterized the C.fasciculata U3 snoRNA, which has the potential for base-pairing with pre-rRNA sequences. Finally, we demonstrate that biosynthesis of large subunit rRNA in both C. fasciculata and Trypanosoma brucei involves 3'-terminal addition of three A residues that are not present in the corresponding DNA sequences.

  19. Investigation of a miRNA-Induced Gene Silencing Technique in Petunia Reveals Alterations in miR173 Precursor Processing and the Accumulation of Secondary siRNAs from Endogenous Genes.

    Directory of Open Access Journals (Sweden)

    Yao Han

    Full Text Available MIGS (miRNA-induced gene silencing is a straightforward and efficient gene silencing technique in Arabidopsis. It works by exploiting miR173 to trigger the production of phasiRNAs (phased small interfering RNAs. MIGS can be used in plant species other than Arabidopsis by co-expression of miR173 and target gene fragments fused to an upstream miR173 target site. However, the efficiency and technical mechanisms have not been thoroughly investigated in other plants. In this work, two vectors, pMIGS-chs and pMIGS-pds, were constructed and transformed into petunia plants. The transgenic plants showed CHS (chalcone synthase and PDS (phytoene desaturase gene-silencing phenotypes respectively, indicating that MIGS functions in petunia. MIGS-chs plants were used to investigate the mechanisms of this technique in petunia. Results of 5'- RACE showed that the miR173 target site was cleaved at the expected position and that endogenous CHS genes were cut at multiple positions. Small RNA deep sequencing analysis showed that the processing of Arabidopsis miR173 precursors in MIGS-chs transgenic petunia plants did not occur in exactly the same way as in Arabidopsis, suggesting differences in the machinery of miRNA processing between plant species. Small RNAs in-phase with the miR173 cleavage register were produced immediately downstream from the cleavage site and out-of-phase small RNAs were accumulated at relatively high levels from processing cycle 5 onwards. Secondary siRNAs were generated from multiple sites of endogenous CHS-A and CHS-J genes, indicating that miR173 cleavage induced siRNAs have the same ability to initiate siRNA transitivity as the siRNAs functioning in co-suppression and hpRNA silencing. On account of the simplicity of vector construction and the transitive amplification of signals from endogenous transcripts, MIGS is a good alternative gene silencing method for plants, especially for silencing a cluster of homologous genes with redundant

  20. Improved Laboratory Transition Probabilities for Ce II, Application to the Cerium Abundances of the Sun and Five r-process Rich, Metal-Poor Stars, and Rare Earth Lab Data

    CERN Document Server

    Lawler, J E; Cowan, J J; Ivans, I I; Hartog, E A Den

    2009-01-01

    Recent radiative lifetime measurements accurate to +/- 5% using laser-induced fluorescence (LIF) on 43 even-parity and 15 odd-parity levels of Ce II have been combined with new branching fractions measured using a Fourier transform spectrometer (FTS) to determine transition probabilities for 921 lines of Ce II. This improved laboratory data set has been used to determine a new solar photospheric Ce abundance, log epsilon = 1.61 +/- 0.01 (sigma = 0.06 from 45 lines), a value in excellent agreement with the recommended meteoritic abundance, log epsilon = 1.61 +/- 0.02. Revised Ce abundances have also been derived for the r-process-rich metal-poor giant stars BD+17 3248, CS 22892-052, CS 31082-001, HD 115444 and HD 221170. Between 26 and 40 lines were used for determining the Ce abundance in these five stars, yielding a small statistical uncertainty of 0.01 dex similar to the Solar result. The relative abundances in the metal-poor stars of Ce and Eu, a nearly pure r-process element in the Sun, matches r-process ...

  1. 77 FR 1656 - Proposed Establishment of Restricted Areas R-5402, R-5403A, R-5403B, R-5403C, R-5403D, R-5403E, R...

    Science.gov (United States)

    2012-01-11

    ... Federal Aviation Administration 14 CFR Part 71 RIN 2120-AI92 Proposed Establishment of Restricted Areas R-5402, R-5403A, R- 5403B, R-5403C, R-5403D, R-5403E, R-5403F; Devils Lake, ND AGENCY: Federal Aviation... Areas R-5402, R-5403A, R-5403B, R- 5403C, R-5403D, R-5403E, R-5403F; Devils Lake, ND......

  2. SGNP: an essential Stress Granule/Nucleolar Protein potentially involved in 5.8s rRNA processing/transport.

    Directory of Open Access Journals (Sweden)

    Chun-Hong Zhu

    Full Text Available BACKGROUND: Stress Granules (SG are sites of accumulation of stalled initiation complexes that are induced following a variety of cellular insults. In a genetic screen for factors involved in protecting human myoblasts from acute oxidative stress, we identified a gene encoding a protein we designate SGNP (Stress Granule and Nucleolar Protein. METHODOLOGY/PRINCIPAL FINDINGS: A gene-trap insertional mutagenesis screen produced one insertion that conferred resistance to sodium arsenite. RT-PCR/3' RACE was used to identify the endogenous gene expressed as a GFP-fusion transcript. SGNP is localized in both the cytoplasm and nucleolus and defines a non-nucleolar compartment containing 5.8S rRNA, a component of the 60S ribosomal subunit. Under oxidative stress, SGNP nucleolar localization decreases and it rapidly co-localizes with stress granules. The decrease in nucleolar SGNP following oxidative stress was accompanied by a large increase in nucleolar 5.8S rRNA. Knockdown of SGNP with shRNA increased global mRNA translation but induced growth arrest and cell death. CONCLUSIONS: These results suggest that SGNP is an essential gene that may be involved in ribosomal biogenesis and translational control in response to oxidative stress.

  3. Modifications structurales des résidus lors du procédé de viscoréduction Structural Changes in Residues During the Visbreaking Process

    Directory of Open Access Journals (Sweden)

    Favre A.

    2006-11-01

    Full Text Available Les asphaltènes et les maltènes d'un résidu sous vide Safaniya et ceux issus de la recette de viscoréduction correspondante sont étudiés. Vu la complexité des produits, plusieurs fractionnements sont pratiqués (chromatographie en phase liquide, chromatographie échangeuse d'ions. Les produits et leurs fractions sont ensuite caractérisés par RMN, IR, analyse élémentaire, tonométrie, diffraction et diffusion centrale des rayons X. Les résultats mettent en évidence des différences notables et permettent de comprendre le comportement des produits lourds du pétrole au cours du craquage thermique et ainsi tenter d'améliorer te taux de conversion. The asphaltenes and maltenes from a Safaniya vacuum residue and those coming from the corresponding visbreaking product are analyzed. Given the complexity of the products, several fractionations are performed (liquid chromatography, ion-exchange chromatography. The products and their fractions are then characterized by NMR, IR, elemental analysis, tonometry, X-ray diffraction and small ange X-ray scattering. The results reveal appreciable differences and enable the behavior of heavy petroleum products to be understood during thermal cracking. So an effort can be made to improve the rate of conversion.

  4. Linking supply to demand: the neuronal monocarboxylate transporter MCT2 and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid receptor GluR2/3 subunit are associated in a common trafficking process.

    Science.gov (United States)

    Pierre, Karin; Chatton, Jean-Yves; Parent, Annabelle; Repond, Cendrine; Gardoni, Fabrizio; Di Luca, Monica; Pellerin, Luc

    2009-05-01

    MCT2 is the major neuronal monocarboxylate transporter (MCT) that allows the supply of alternative energy substrates such as lactate to neurons. Recent evidence obtained by electron microscopy has demonstrated that MCT2, like alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionic acid (AMPA) receptors, is localized in dendritic spines of glutamatergic synapses. Using immunofluorescence, we show in this study that MCT2 colocalizes extensively with GluR2/3 subunits of AMPA receptors in neurons from various mouse brain regions as well as in cultured neurons. It also colocalizes with GluR2/3-interacting proteins, such as C-kinase-interacting protein 1, glutamate receptor-interacting protein 1 and clathrin adaptor protein. Coimmunoprecipitation of MCT2 with GluR2/3 and C-kinase-interacting protein 1 suggests their close interaction within spines. Parallel changes in the localization of both MCT2 and GluR2/3 subunits at and beneath the plasma membrane upon various stimulation paradigms were unraveled using an original immunocytochemical and transfection approach combined with three-dimensional image reconstruction. Cell culture incubation with AMPA or insulin triggered a marked intracellular accumulation of both MCT2 and GluR2/3, whereas both tumor necrosis factor alpha and glycine (with glutamate) increased their cell surface immunolabeling. Similar results were obtained using Western blots performed on membrane or cytoplasm-enriched cell fractions. Finally, an enhanced lactate flux into neurons was demonstrated after MCT2 translocation on the cell surface. These observations provide unequivocal evidence that MCT2 is linked to AMPA receptor GluR2/3 subunits and undergoes a similar translocation process in neurons upon activation. MCT2 emerges as a novel component of the synaptic machinery putatively linking neuroenergetics to synaptic transmission.

  5. Mycobacterial RNA isolation optimized for non-coding RNA: high fidelity isolation of 5S rRNA from Mycobacterium bovis BCG reveals novel post-transcriptional processing and a complete spectrum of modified ribonucleosides.

    Science.gov (United States)

    Hia, Fabian; Chionh, Yok Hian; Pang, Yan Ling Joy; DeMott, Michael S; McBee, Megan E; Dedon, Peter C

    2015-03-11

    A major challenge in the study of mycobacterial RNA biology is the lack of a comprehensive RNA isolation method that overcomes the unusual cell wall to faithfully yield the full spectrum of non-coding RNA (ncRNA) species. Here, we describe a simple and robust procedure optimized for the isolation of total ncRNA, including 5S, 16S and 23S ribosomal RNA (rRNA) and tRNA, from mycobacteria, using Mycobacterium bovis BCG to illustrate the method. Based on a combination of mechanical disruption and liquid and solid-phase technologies, the method produces all major species of ncRNA in high yield and with high integrity, enabling direct chemical and sequence analysis of the ncRNA species. The reproducibility of the method with BCG was evident in bioanalyzer electrophoretic analysis of isolated RNA, which revealed quantitatively significant differences in the ncRNA profiles of exponentially growing and non-replicating hypoxic bacilli. The method also overcame an historical inconsistency in 5S rRNA isolation, with direct sequencing revealing a novel post-transcriptional processing of 5S rRNA to its functional form and with chemical analysis revealing seven post-transcriptional ribonucleoside modifications in the 5S rRNA. This optimized RNA isolation procedure thus provides a means to more rigorously explore the biology of ncRNA species in mycobacteria. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  6. Assessment of carbon-rejection processes as a method of CO{sub 2} abatement. IEA greenhouse gas R and D programme United Kingdom

    Energy Technology Data Exchange (ETDEWEB)

    Lugten, P.E.; Jansen, D.; Van der Burgt, M.J.; Carp, A. [ECN Clean Fossil Fuels, Petten (Netherlands)

    2000-06-01

    As an alternative to the capture and storage Of CO2, it has been suggested that processes which recover energy from the hydrogen content and reject the carbon content of fossil fuels as a solid would be potentially attractive methods of avoiding CO2 emissions. Such processes avoid the need to store CO2 for many years in a save repository. The key reaction involved is thermal decomposition of a fossil fuel. In case of methane decomposition roughly 50% of the energy remains in the rejected carbon and is not recovered. Any version of this process that only makes use of the hydrogen product will therefore have at most a theoretical efficiency of 50%. In practice the efficiency is likely to be significantly less as the reaction is strongly endothermic, 75% of the input mass is rejected as carbon. Some researchers have come to the conclusion that, for such a process to be of interest, the rejected carbon has to be used rather than just stored indefinitely. There are 2 major suggestions involving use of the carbon, which are assessed as part of this study: (1) Use the carbon in established uses for carbon black; and (2) Use the carbon in the metallurgical industry. An alternative application of this technology which will also be assessed in this study has been suggested elsewhere. In the there proposed 'Camol process', the thermal decomposition of methane is integrated with the production of other energy products. Carbon is rejected and the hydrogen produced is reacted with CO2 recovered from power generation to make methanol. The integrated process claimed to result in a net reduction in CO2 emissions compared to conventional processing of oil for transport fuels, together with power generation from fossil fuels. The overall objective of this study is to assess the competitiveness of carbon rejection schemes as means of CO2 abatement. The scope of work for this study is specified in 3 tasks: (1) different types of carbon rejection processes will be assessed to

  7. Scale Effects in Laboratory and Pilot-Plant Reactors for Trickle-Flow Processes Les conséquences de l'extrapolation appliquée aux procédés à écoulement ruisselant réalisés en laboratoire et dans les réacteurs des unités-pilotes

    Directory of Open Access Journals (Sweden)

    Sie S. T.

    2006-11-01

    Full Text Available Research and development studies in a laboratory are necessarily conducted on a scale which is orders of magnitude smaller than that in commercial practice. In the case of the development and commercialization of an unprecedented novel process technology, available laboratory results have to be translated into envisaged technology on a commercial scale, i. e. the problem is that of scaling-up. However, in many circumstances the commercial technology is more or less defined as far as type of reactor is concerned and laboratory studies are concerned with the generation of predictive information on the behaviour of new catalysts, alternative feedstocks, etc. , in such a reactor. In many cases the complexity of feed composition and reaction kinetics preclude the prediction to be made on the basis of a combination of fundamental kinetic data and computer models, so that there is no other option than to simulate the commercial reactor on a laboratory scale, i. e. the problem is that of scaling-down. From the point of view of R & D Defficiency, the scale of the laboratory experiments should be as small as possible without detracting from the meaningfulness of the results. In the present paper some problems in the scaling-down of a trickle-flow reactor as applied in hydrotreating processes to kinetically equivalent laboratory reactors of different sizes will be discussed. Two main aspects relating to inequalities in fluid dynamics resulting from the differences in scale will be treated in more detail, viz. deviations from ideal plug flow and non ideal wetting or irrigation of the catalyst particles. Although a laboratory reactor can never be a true small-scale replica of a commercial trickle-flow reactor in all respects, it can nevertheless be made to provide representative data as far as the catalytic conversion aspects are concerned. By ressorting to measures such as catalyst bed dilution with fine catalytically inert material it proves possible to

  8. Test Review: R. W. Keith "SCAN-3 for Adolescents and Adults--Tests for Auditory Processing Disorders". San Antonio, TX: Pearson, 2009

    Science.gov (United States)

    Lovett, Benjamin J.; Johnson, Theodore L.

    2010-01-01

    The SCAN-3 is a battery of tasks used for the screening and diagnosis of auditory processing disorder. It is available in two versions, one for children (the SCAN-3: C) and one for adolescents and adults (the SCAN-3: A); the latter version of the SCAN-3 is reviewed in this article, although it is very similar to the child version. The primary…

  9. Prism adaptation does not alter configural processing of faces [v1; ref status: indexed, http://f1000r.es/1wk

    Directory of Open Access Journals (Sweden)

    Janet H. Bultitude

    2013-10-01

    Full Text Available Patients with hemispatial neglect (‘neglect’ following a brain lesion show difficulty responding or orienting to objects and events on the left side of space. Substantial evidence supports the use of a sensorimotor training technique called prism adaptation as a treatment for neglect. Reaching for visual targets viewed through prismatic lenses that induce a rightward shift in the visual image results in a leftward recalibration of reaching movements that is accompanied by a reduction of symptoms in patients with neglect. The understanding of prism adaptation has also been advanced through studies of healthy participants, in whom adaptation to leftward prismatic shifts results in temporary neglect-like performance. Interestingly, prism adaptation can also alter aspects of non-lateralised spatial attention. We previously demonstrated that prism adaptation alters the extent to which neglect patients and healthy participants process local features versus global configurations of visual stimuli. Since deficits in non-lateralised spatial attention are thought to contribute to the severity of neglect symptoms, it is possible that the effect of prism adaptation on these deficits contributes to its efficacy. This study examines the pervasiveness of the effects of prism adaptation on perception by examining the effect of prism adaptation on configural face processing using a composite face task. The composite face task is a persuasive demonstration of the automatic global-level processing of faces: the top and bottom halves of two familiar faces form a seemingly new, unknown face when viewed together. Participants identified the top or bottom halves of composite faces before and after prism adaptation. Sensorimotor adaptation was confirmed by significant pointing aftereffect, however there was no significant change in the extent to which the irrelevant face half interfered with processing. The results support the proposal that the therapeutic effects

  10. JSS Journal of Statistical Software January 2013, Volume 52, Issue 4. http://www.jstatsoft.org/ lgcp : Inference with Spatial and Spatio-Temporal Log-Gaussian Cox Processes in R

    Directory of Open Access Journals (Sweden)

    Benjamin M. Taylor

    2013-01-01

    Full Text Available This paper introduces an R package for spatial and spatio-temporal prediction and forecasting for log-Gaussian Cox processes. The main computational tool for these models is Markov chain Monte Carlo (MCMC and the new package, lgcp, therefore also provides an extensible suite of functions for implementing MCMC algorithms for processes of this type. The modeling framework and details of inferential procedures are first presented before a tour of lgcp functionality is given via a walk-through data-analysis. Topics covered include reading in and converting data, estimation of the key components and parameters of the model, specifying output and simulation quantities, computation of Monte Carlo expectations, post-processing and simulation of data sets.

  11. The Earth's magnetosphere is 165 R(sub E) long: Self-consistent currents, convection, magnetospheric structure, and processes for northward interplanetary magnetic field

    Science.gov (United States)

    Fedder, J. A.; Lyon, J. G.

    1995-01-01

    The subject of this paper is a self-consistent, magnetohydrodynamic numerical realization for the Earth's magnetosphere which is in a quasi-steady dynamic equilibrium for a due northward interplanetary magnetic field (IMF). Although a few hours of steady northward IMF are required for this asymptotic state to be set up, it should still be of considerable theoretical interest because it constitutes a 'ground state' for the solar wind-magnetosphere interaction. Moreover, particular features of this ground state magnetosphere should be observable even under less extreme solar wind conditions. Certain characteristics of this magnetosphere, namely, NBZ Birkeland currents, four-cell ionospheric convection, a relatively weak cross-polar potential, and a prominent flow boundary layer, are widely expected. Other characteristics, such as no open tail lobes, no Earth-connected magnetic flux beyond 155 R(sub E) downstream, magnetic merging in a closed topology at the cusps, and a 'tadpole' shaped magnetospheric boundary, might not be expected. In this paper, we will present the evidence for this unusual but interesting magnetospheric equilibrium. We will also discuss our present understanding of this singular state.

  12. The spliceosome U2 snRNP factors promote genome stability through distinct mechanisms; transcription of repair factors and R-loop processing.

    Science.gov (United States)

    Tanikawa, M; Sanjiv, K; Helleday, T; Herr, P; Mortusewicz, O

    2016-12-19

    Recent whole-exome sequencing of malignancies have detected recurrent somatic mutations in U2 small nuclear ribonucleoprotein complex (snRNP) components of the spliceosome. These factors have also been identified as novel players in the DNA-damage response (DDR) in several genome-wide screens and proteomic analysis. Although accumulating evidence implies that the spliceosome has an important role in genome stability and is an emerging hallmark of cancer, its precise role in DNA repair still remains elusive. Here we identify two distinct mechanisms of how spliceosome U2 snRNP factors contribute to genome stability. We show that the spliceosome maintains protein levels of essential repair factors, thus contributing to homologous recombination repair. In addition, real-time laser microirradiation analysis identified rapid recruitment of the U2 snRNP factor SNRPA1 to DNA-damage sites. Functional analysis of SNRPA1 revealed a more immediate and direct role in preventing R-loop-induced DNA damage. Our present study implies a complex interrelation between transcription, mRNA splicing and the DDR. Cells require rapid spatio-temporal coordination of these chromatin transactions to cope with various forms of genotoxic stress.

  13. How Do People Become W.E.I.R.D.? Migration Reveals the Cultural Transmission Mechanisms Underlying Variation in Psychological Processes

    OpenAIRE

    Mesoudi, Alex; Magid, Kesson; Hussain, Delwar

    2016-01-01

    Cultural psychologists have shown that people from Western, Educated, Industrialised, Rich, Democratic (WEIRD) countries often exhibit different psychological processing to people from less-WEIRD countries. The former exhibit more individualistic and less collectivistic social orientation, and more analytic and less holistic cognition, than non-Westerners. Yet the mechanisms responsible for maintaining this cultural variation are unclear. Immigration is an ideal ‘natural experiment’ for uncov...

  14. How do people become W.E.I.R.D.? Migration reveals the cultural transmission mechanisms underlying variation in psychological processes.

    OpenAIRE

    Alex Mesoudi; Kesson Magid; Delwar Hussain

    2016-01-01

    Cultural psychologists have shown that people from Western, Educated, Industrialised, Rich, Democratic (WEIRD) countries often exhibit different psychological processing to people from less-WEIRD countries. The former exhibit more individualistic and less collectivistic social orientation, and more analytic and less holistic cognition, than non-Westerners. Yet the mechanisms responsible for maintaining this cultural variation are unclear. Immigration is an ideal 'natural experiment' for uncov...

  15. Multi-tiered system of support incorporating the R.E.N.E.W. process and its relationship to perception of school safety and office discipline referrals

    Science.gov (United States)

    Flood, Molly M.

    This study examined the relationship between the fidelity of multi-tier school-wide positive behavior interventions and supports (SWPBIS) and staff perception of school safety and office discipline referrals. This research provided a case study on multi-tier supports and interventions, and the RENEW person-centered planning process in an alternative special education center following the implementation of a multi-tier SWPBIS model. Pennsylvania is one of several states looking to adopt an effective Tier III behavioral tool. The research described the results of an analysis of implementation fidelity on a multi-tiered school-wide positive behavior support model developed at a special education center operated by a public school system entity. This research explored the fidelity of SWPBIS implementation; analyzed the relationship of SWPBIS to school climate as measured by staff perceptions and reduction of office discipline referrals (ODR); explored tier III supports incorporating a process Rehabilitation and Empowerment, Natural Supports, Education and Work (RENEW); and investigated the potential sustainability of the RENEW process as a multi-tier system of support. This study investigated staff perceptions on integrated supports between schools and communities and identified the degree of relationship to school risk factors, school protective factors, and office discipline referrals following the building of cooperative partnerships between Systems of Care and Local Education Agencies.

  16. Primary Processing

    NARCIS (Netherlands)

    Mulder, W.J.; Harmsen, P.F.H.; Sanders, J.P.M.; Carre, P.; Kamm, B.; Schoenicke, P.

    2012-01-01

    Primary processing of oil-containing material involves pre-treatment processes, oil recovery processes and the extraction and valorisation of valuable compounds from waste streams. Pre-treatment processes, e.g. thermal, enzymatic, electrical and radio frequency, have an important effect on the oil r

  17. Systematic use of universal 16S rRNA gene polymerase chain reaction (PCR) and sequencing for processing pleural effusions improves conventional culture techniques.

    Science.gov (United States)

    Insa, Rosario; Marín, Mercedes; Martín, Adoración; Martín-Rabadán, Pablo; Alcalá, Luís; Cercenado, Emilia; Calatayud, Laura; Liñares, Josefina; Bouza, Emilio

    2012-03-01

    Conventional culture of pleural fluid samples frequently provides false-negative results. Universal polymerase chain reaction (PCR) of the 16S ribosomal ribonucleic acid (rRNA) gene (16S PCR) has proven useful in the diagnosis of various bacterial infections. We conducted a prospective study to assess the value of 16S PCR in the etiologic diagnosis of pleural effusion. All pleural fluid samples received for culture were also studied using 16S PCR. Positive samples were sequenced for identification. Clinical records and conventional culture results were analyzed to classify pleural fluid samples as infected or not infected. We studied 723 samples. We excluded 188 samples because they were obtained from a long-term chest tube, there was a diagnosis of mycobacterial infection, or there were insufficient data to classify the episode. Finally, 535 pleural fluid samples were analyzed. According to our criteria, 82 (15.3%) were infected and 453 (84.7%) were not infected. In the infected samples, 16S PCR was positive in 67 samples (81.7%) while conventional culture was positive in 45 (54.9%). There were 4 false positives with 16S PCR (0.9%) and 12 with culture (2.6%). The values for the etiologic diagnosis of bacterial pleural effusion of conventional culture compared with 16S PCR were as follows: sensitivity, 54.9%/81.7%; specificity, 97.4%/99.1%; positive predictive value, 76.3%/94.4%; negative predictive value, 92.6%/96.8%; and accuracy, 90.8%/96.5%.When compared with conventional culture, 16S PCR plus sequencing substantially improves the etiologic diagnosis of infectious pleural effusion. In our opinion, this technique should be added to the routine diagnostic armamentarium of clinical microbiology laboratories.

  18. Development of a Validated LC Method for Separation of Process-Related Impurities Including the R-Enantiomer of S-Pramipexole on Polysaccharide Chiral Stationary Phases.

    Science.gov (United States)

    Ramisetti, Nageswara Rao; Kuntamukkala, Ramakrishna; Arnipalli, Manikanta Swamy

    2015-07-01

    Despite the availability of a few methods for individual separation of S-pramipexole from its process-related impurities, no common liquid chromatography (LC) method is reported so far in the literature. The present article describes the development of a single-run LC method for simultaneous determination of S-pramipexole and its enantiomeric and process-related impurities on a Chiralpak AD-H (150 x 4.6 mm, 5μm) column using n-hexane/ethanol/n-butylamine (75:25:0.1 v/v/v) as a mobile phase in an isocratic mode of elution at a flow rate of 1.2 ml/min at 30°C. The chromatographic eluents were monitored at a wavelength of 260 nm using a photodiode array detector. Excellent enantioseparation with good resolutions (Rs ≥ 2.88) and peak shapes (As ≤ 1.21) for all analytes was achieved. The proposed method was validated according to International Conference Harmonization (ICH) guidelines in terms of accuracy, precision, sensitivity, and linearity. Limits of quantification of impurities (0.25-0.55 μg/ml) indicate the highest sensitivity achievable by the proposed method. The method has an advantage of selectivity and suitability for routine determination of not only chiral impurity but also all possible related substances in active pharmaceutical ingredients of S-pramipexole.

  19. On the Load-Unload (L-U) and Force-Release (F-R) Algorithms for Simulating Brittle Fracture Processes via Lattice Models

    KAUST Repository

    Liu, Jinxing

    2011-11-11

    General summaries on the load-unload and force-release methods indicate that the two methods are efficient for different-charactered quasi-static failures; therefore, it is important to choose the right one for different applications. Then we take, as an example, the case where the release of the ruptured element\\'s internal force is infinitely slower than the relaxation of the lattice system and analyze why the force-release method works better than the load-unload method in this particular case. Different trial deformation fields are used by them to track the next equilibrium state. Force-release method ensures that the deformation throughout the whole failure process coincides exactly with the controlled-displacement boundary conditions and we utilize the \\'left modulus\\' concept to prove that this method satisfies the energetic evolution in the force-displacement diagram; both of which are not satisfied by the load-unload method. To illustrate that the force-release method is not just another form of the load-unload method, a tensile test on a specifically designed system is analyzed to further compare the above two methods, showing that their predicted sequences of elemental failures can be different. In closing, we simulate the uniaxial tensile test on a beam lattice system by the load-unload and force-release methods and exploit the details of the resulting fracture processes. © The Author(s), 2011.

  20. Processus de réorientation des variantes de martensite dans un monocristal de Cu Al NiReorientation process of martensite variants in a Cu Al Ni monocrystal

    Science.gov (United States)

    Blanc, Pascal; Lexcellent, Christian

    2003-04-01

    On the one hand, Chu (Thesis, Minnesota, 1993), Abeyaratne et al. (Philos. Mag. A 73 (2) (1996) 457-497) performed biaxial tensile tests on a single crystal Cu-Al-Ni plate, in order to analyze the reorientation process of martensite variants. On the other hand, use is made of a constitutive model with n+1 internal variables (the volume fractions of austenite and of the n martensite variants) specific to the thermomechanical behavior of SMA single crystals in order to simulate the martensite variant reorientation. The comparison between experimental results and model prediction is fairly good. To cite this article: P. Blanc, C. Lexcellent, C. R. Mecanique 331 (2003).

  1. System performance with R407A, R407B, R407C compared to R22

    DEFF Research Database (Denmark)

    Knudsen, Hans Jørgen Høgaard

    1997-01-01

    The article presents the results obtained by substituting R22 with mixture of R32/R125/R134A (R407A, R407B and R407C) in an existing refrigeration plant. Cooling capacity, coefficient of performance and heat transfer coefficient in the evaporator have been measured.The results show that for R407C...

  2. Particles, processes and materials for modern energy needs: Development of a DOE-EPSCoR project in Puerto Rico. Final report for September 30, 1997 - August 31, 2000

    Energy Technology Data Exchange (ETDEWEB)

    Weiner, Brad R.

    2000-09-29

    Twenty-eight (28) faculty researchers focused on High Energy Particle Physics, Novel Thin Film Materials for Optoelectronic Applications, and Catalytic Processes for Energy Sources and Environmental Detoxification to address problems cited as priorities by the DOE and local agencies. The High Energy Particle Physics cluster has DOE-competitive funding, and the number of cluster investigators who have competitive mainstream funding has increased from 2 to 13 since the inception of the program. In this reporting period, 8 postdoctorals, 38 graduate studnets, and 23 undergraduates were involved in DOE projects, and 191 publications and 238 presentations were generated. The UPR-Arecibo Integrated Science Multi-Use Laboratory provided workshops and other activities that directly impacted 360 teachers and 600 students and indirectly impacted over 25,000 through the enhancement of teachers' skills and knowledge.

  3. How Do People Become W.E.I.R.D.? Migration Reveals the Cultural Transmission Mechanisms Underlying Variation in Psychological Processes.

    Directory of Open Access Journals (Sweden)

    Alex Mesoudi

    Full Text Available Cultural psychologists have shown that people from Western, Educated, Industrialised, Rich, Democratic (WEIRD countries often exhibit different psychological processing to people from less-WEIRD countries. The former exhibit more individualistic and less collectivistic social orientation, and more analytic and less holistic cognition, than non-Westerners. Yet the mechanisms responsible for maintaining this cultural variation are unclear. Immigration is an ideal 'natural experiment' for uncovering such mechanisms. We used a battery of psychological measures previously shown to vary cross-culturally to compare the social orientation and cognitive style of 286 residents of East London from three cultural backgrounds: (i 1st-generation British Bangladeshi immigrants; (ii 2nd-generation British Bangladeshis raised in the UK to Bangladeshi-raised parents; and (iii non-migrants whose parents were born and raised in the UK. Model comparison revealed that individualism and dispositional attribution, typical of Western societies, are driven primarily by horizontal cultural transmission (e.g. via mass media, with parents and other family members having little or no effect, while collectivism, social closeness and situational attribution were driven by a mix of vertical/oblique cultural transmission (e.g. via family contact and horizontal cultural transmission. These individual-level transmission dynamics can explain hitherto puzzling population-level phenomena, such as the partial acculturation of 2nd-generation immigrants on measures such as collectivism (due to the mix of vertical and horizontal cultural transmission, or the observation in several countries of increasing individualism (which is transmitted horizontally and therefore rapidly despite little corresponding change in collectivism (which is transmitted partly vertically and therefore more slowly. Further consideration of cultural transmission mechanisms, in conjunction with the study of

  4. How Do People Become W.E.I.R.D.? Migration Reveals the Cultural Transmission Mechanisms Underlying Variation in Psychological Processes.

    Science.gov (United States)

    Mesoudi, Alex; Magid, Kesson; Hussain, Delwar

    2016-01-01

    Cultural psychologists have shown that people from Western, Educated, Industrialised, Rich, Democratic (WEIRD) countries often exhibit different psychological processing to people from less-WEIRD countries. The former exhibit more individualistic and less collectivistic social orientation, and more analytic and less holistic cognition, than non-Westerners. Yet the mechanisms responsible for maintaining this cultural variation are unclear. Immigration is an ideal 'natural experiment' for uncovering such mechanisms. We used a battery of psychological measures previously shown to vary cross-culturally to compare the social orientation and cognitive style of 286 residents of East London from three cultural backgrounds: (i) 1st-generation British Bangladeshi immigrants; (ii) 2nd-generation British Bangladeshis raised in the UK to Bangladeshi-raised parents; and (iii) non-migrants whose parents were born and raised in the UK. Model comparison revealed that individualism and dispositional attribution, typical of Western societies, are driven primarily by horizontal cultural transmission (e.g. via mass media), with parents and other family members having little or no effect, while collectivism, social closeness and situational attribution were driven by a mix of vertical/oblique cultural transmission (e.g. via family contact) and horizontal cultural transmission. These individual-level transmission dynamics can explain hitherto puzzling population-level phenomena, such as the partial acculturation of 2nd-generation immigrants on measures such as collectivism (due to the mix of vertical and horizontal cultural transmission), or the observation in several countries of increasing individualism (which is transmitted horizontally and therefore rapidly) despite little corresponding change in collectivism (which is transmitted partly vertically and therefore more slowly). Further consideration of cultural transmission mechanisms, in conjunction with the study of migrant

  5. The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA.

    Science.gov (United States)

    Du, Xianming; Rao, Malireddi R K Subba; Chen, Xue Qin; Wu, Wei; Mahalingam, Sundarasamy; Balasundaram, David

    2006-01-01

    Grn1p from fission yeast and GNL3L from human cells, two putative GTPases from the novel HSR1_MMR1 GTP-binding protein subfamily with circularly permuted G-motifs play a critical role in maintaining normal cell growth. Deletion of Grn1 resulted in a severe growth defect, a marked reduction in mature rRNA species with a concomitant accumulation of the 35S pre-rRNA transcript, and failure to export the ribosomal protein Rpl25a from the nucleolus. Deleting any of the Grn1p G-domain motifs resulted in a null phenotype and nuclear/nucleolar localization consistent with the lack of nucleolar export of preribosomes accompanied by a distortion of nucleolar structure. Heterologous expression of GNL3L in a Deltagrn1 mutant restored processing of 35S pre-rRNA, nuclear export of Rpl25a and cell growth to wild-type levels. Genetic complementation in yeast and siRNA knockdown in HeLa cells confirmed the homologous proteins Grn1p and GNL3L are required for growth. Failure of two similar HSR1_MMR1 putative nucleolar GTPases, Nucleostemin (NS), or the dose-dependent response of breast tumor autoantigen NGP-1, to rescue deltagrn1 implied the highly specific roles of Grn1p or GNL3L in nucleolar events. Our analysis uncovers an important role for Grn1p/GNL3L within this unique group of nucleolar GTPases.

  6. Process Mechanism and Approach for Knowledge Transfer within R&D Unit%企业研发团队内部技术知识转移的过程机理与途径研究

    Institute of Scientific and Technical Information of China (English)

    疏礼兵

    2012-01-01

    在有关知识转移过程机制的国内外研究基础上,着重从团队层面揭示了企业研发团队内部技术知识转移的一般过程和内在机理,进而借用NONAKA等的模型思想,设计了研发团队内部技术知识转移的途径框架,解析知识转移的具体途径和方式,从研发团队内部技术知识转移视角为我国企业自主性技术创新绩效提升提供了几点思路.%The transfer of knowledge has become the key foundation to build competitive advantage for many organizations. Based on related literature review, this paper reveals the general process and inherent mechanism of technological knowledge transfer from the dimension of R&D unit. Then the framework of transfer ways within R&D unit is designed through using the model of Nonaka and Takeuchi to explain the specific approaches and means of technological knowledge transfer. Finally some ideas are provided for improvement of Chinese enterprises' independent innovation from the perspective of internal knowledge transfer performance of R&D unit.

  7. Modeling Chemical EOR Processes: Some Illustrations from Lab to Reservoir Scale Modélisation des procédés EOR chimiques : du laboratoire au réservoir

    Directory of Open Access Journals (Sweden)

    Douarche F.

    2013-02-01

    Full Text Available Chemical flooding, SP (Surfactant Polymer or ASP (Alkali-Surfactant-Polymer, are of increasing interest due to the need to increase oil production. Design of chemical processes is very project specific and requires case by case studies including various steps among which reservoir data analysis, chemical formulations, coreflood validations and reservoir simulation. Every step is dependent on the preceding ones and the last reservoir simulation step gathers all the information collected during the project. In this paper, we present a chemical simulator describing two phase flow with chemical transport of alkali, surfactant, polymer and salinity. Two phase flow is related to capillary desaturation curve through the decrease of oil-water interfacial tension. Physical chemistry reactions are described either with a thermodynamic approach or a simplified one using tables or simplified physics to be compatible with large scale reservoir simulations. In this paper, we describe the simulator and present results of numerous experiments specially designed to validate the model: alkaline injections of carbonates and borates, surfactant adsorption experiments at different salinities and pH, systematic effect of salinity on interfacial tension and oil recovery with/without salinity gradient. The good agreement between the experimental and numerical oil recoveries and chemical compositions is very encouraging and supports the validity of the physics implemented in the simulator. In particular, the dominant effect of pH on adsorption and the importance of a salinity gradient on oil recovery is highlighted by numerical simulation. Finally, a sensitivity study at the reservoir scale is presented to illustrate relevant factors for the implementation of an economic surfactant-based process. Les procédés de récupération tertiaire par voie chimique, SP (Surfactant Polymer ou ASP (Alkali-Surfactant-Polymer, sont en plein essor du fait d’une demande croissante

  8. 大鼠脑皮质NF-κB和miR-146a在轻型脑创伤后炎症反应过程中的协同作用%Synergistic effect of NF-κB and miR-146a in inflammatory reaction process after mild traumatic brain injury in rats

    Institute of Scientific and Technical Information of China (English)

    贺学农; 张毅; 周昌龙; 夏小辉

    2012-01-01

    To investigate the action mechanism of cortex NF-kB activation and the miR-146a transcription regulation mode in the inflammatory reaction process after mild traumatic brain injury(TBI) in rats. Methods The 60 healthy male SD rats were selected and randomly divided into the control group(n=10) and the mild traumatic brain injury(TBI) group(n = 50). The mild TBI group was sub divided into five subgroups according to different time points: 1,3 ,6 ,12 ,24 h after brain injury. 10% chlo-ralic hydrasCO. 3 mL/100 g) was intraperitoneally injected. The Marmarou s method was adopted to induce rat mild TBI by dropping the copper rod, weighed 4 50 g and 18 mm in diameter,from 1 M height. The control group was only given corresponding anesthesia, scalp incision and suture. The changes of cortex NF-kB and miR-14 6a were compared between the two groups using real-time quantitative PCR and Western blot methods. Results At 1,3,6,12,24 h after TBI,miR-146a expression was significantly up-regulated by 1. 21 + 0. 15,1. 73 + 0. 29,2. 36 + 0. 24,3. 60 + 0. 37,1. 97 + 0. 26 fold compared with the control group, which reached to the expression peak at 6 - 12 h after TBI, its transcription level was down-regulated at 24 h. The activation and nuclear translocation of NF-kB was basically similar to the expression pattern of miR-146a. Conclusion The expression of miR-146a in mild TBI is significantly up-regulated, NF-kB enhances the transcription level of miR-146a by upstream control components. NF-kB-miR-14 6a pathway may play an important role in promoting the inflammatory reaction process after TBI.%目的 探讨轻型脑创伤后大鼠皮质区核因子κB(NF-κB)活化及其microRNA(miRNA)-146a转录调控模式在炎症反应过程中的作用机制.方法 选择健康雄性SD大鼠60只,随机分为对照组(n=10)、轻型脑创伤组(n=50).轻型脑创伤组分为创伤后1、3、6、12和24 h 5个时间点,10%水合氯醛(0.3 mL/100 g)腹腔内

  9. Effects of soil moisture and soil depth on nitrogen mineralization process under Mongolian pine plantations in Zhanggutai sandy land, P. R. China

    Institute of Scientific and Technical Information of China (English)

    CHENFu-sheng; ZENGDe-hui; SINGHAnandNarain; CHENGuang-sheng

    2005-01-01

    The rates of soil N mineralization at soil depths of 0-15, 15-30, 30-45 and 45-0 cm and moisture regimes were measured at three sand-fixation plantations of Pinus sylve.stris var. mongolica by laboratory aerobic incubation method. The results showed that average rates of soil net N-mineralization across soil depth varied from 1.06 to 7.52 mg ~ kg 1.month qat soil depths from 0 to 60 cm. Statistical analyses indicated that the effects of different soil depths, moistures and their interactions on net N-mineralization rates were significant (P<0.05). The net N-mineralization rates significantly decreased with increasing soil depths and at depth 0-15 cm accounted for 60.52% of that at depth of 0-50 cm. There was no difference in soil net N-mineralization rates between half and fully-saturated water treatments, however these rates were substantially higher than that without water treatment (P < 0.05). The factors influencing N mineralization process have to be studied further in these semiarid pine ecosystems.

  10. The M oderating E ffect of IT Capability on the R elationship between Business Process Reengineering Factors and Organizational Performance of Bank s

    Directory of Open Access Journals (Sweden)

    Kabiru Jinjiri Ringim

    2012-08-01

    Full Text Available The objective of this paper is to investigate the moderating effect of IT capability in the relationship of Business Process Reengineering ( BPR factors and the organizational performance. BPR factors are op erationalized by change management, BPR strategy alignment, customer focus, management commitment, IT investment, and adequate financial resources. The IT capability includes IT knowledge, IT operations and IT objects. Data was collected through a hand - del ivery method by sending questionnaires to 560 banks (Commercial, Microfinance and Mortgage. This study used stratified random samplings proportionate to the numbers of the banks for sample selection. The findings showed that IT capability moderated the re lationship between BPR factors such as change management, customer focus, management commitment and overall organizational performance of the bank. Furthermore, the result revealed that IT capability moderated the relationship between IT investment, manage ment commitment and customer service management performance. The outcome of this study provides important insight to researchers for understanding on the effects of BPR factors and IT capability on organizational performance

  11. Mathematical modelling and process optimization of a continuous 5-stage bioreactor cascade for production of poly[-(R)-3-hydroxybutyrate] by Cupriavidus necator.

    Science.gov (United States)

    Horvat, Predrag; Vrana Špoljarić, Ivna; Lopar, Markan; Atlić, Aid; Koller, Martin; Braunegg, Gerhart

    2013-09-01

    A multistage system for poly(hydroxyalkanoate) (PHA) production consisting of five continuous stirred tank reactors in series (5-CSTR) with Cupriavidus necator DSM 545 as production strain was modelled using formal kinetic relations. Partially growth-associated production of PHA under nitrogen limited growth was chosen as modelling strategy, thus the Luedeking-Piret's model of partial growth-associated product synthesis was applied as working hypothesis. Specific growth rate relations adjusted for double substrate (C and N source) limited growth according to Megee et al. and Mankad-Bungay relation were tested. The first stage of the reactor cascade was modelled according to the principle of nutrient balanced continuous biomass production system, the second one as two substrate controlled process, while the three subsequent reactors were adjusted to produce PHB under continuous C source fed and nitrogen deficiency. Simulated results of production obtained by the applied mathematical models and computational optimization indicate that PHB productivity of the whole system could be significantly increased (from experimentally achieved 2.14 g L(-1) h(-1) to simulated 9.95 g L(-1) h(-1)) if certain experimental conditions would have been applied (overall dilution rate, C and N source feed concentration). Additionally, supplemental feeding strategy for switching from batch to continuous mode of cultivation was proposed to avoid substrate inhibition.

  12. Conservação de rúcula minimamente processada produzida em campo aberto e cultivo protegido com agrotêxtil Conservation of minimally processed rocket produced under open field conditions and non woven polypropylene

    Directory of Open Access Journals (Sweden)

    Angela F Gonzalez

    2006-09-01

    Full Text Available Folhas de rúcula produzidas em campo aberto e sob cultivo protegido com agrotêxtil foram minimamente processadas, embaladas inteiras ou picadas em bandejas de poliestireno expandido e cobertas com filme de PVC de 14 micras. O delineamento adotado foi o inteiramente casualizado em esquema fatorial 2x2x2 (ambiente de cultivo, forma de preparo e refrigeração a 0(0C e 10(0C, com quatro repetições por tratamento, totalizando 32 bandejas. Os tratamentos foram armazenados a 0ºC e 10ºC por 10 dias, quando foram avaliadas as variáveis perda de massa (%; pH; sólidos solúveis; acidez titulável; cor e aparência. A conservação a 0ºC promoveu uma diminuição da perda de peso da rúcula minimamente processada. A utilização de folhas inteiras ou minimamente processadas foi significativa para sólidos solúveis sendo os maiores valores encontrados para as folhas inteiras. Para folhas picadas observou-se valores de acidez significativamente maiores para as produzidas sob ambiente natural. Independente da forma de preparo, a rúcula produzida em ambiente natural apresentou menor valor de pH. A cor e aparência da rúcula não foram influenciadas pelos tratamentos.Leaves of rocket salad produced under open field and non woven polypropylene were minimally processed and packed entire or pricked in polyestyrene trays covered with PVC film of 14 micras. The treatments were stored at 0(0C and 10(0C per 10 days, when the variables weight loss (%; pH; soluble solids; titratable acidity; colour and appearance were evaluated. The conservation under 0(0C promoted a reduction of weight loss on rocket salad minimally processed. Using entire or minimally processed leaves were significant for soluble solids the biggest values being found for entire leaves. For pricked leaves bigger values of acidity were observed for the produced ones under natural environment. Independent of the preparation form rocket salad produced under natural environment presented minor

  13. Beta decay of deformed r-process nuclei near A = 80 and A= 160, including odd-A and odd-odd nuclei, with the Skyrme finite-amplitude method

    CERN Document Server

    Shafer, T; Fröhlich, C; McLaughlin, G C; Mumpower, M; Surman, R

    2016-01-01

    After identifying the nuclei in the regions near A =80 and A = 160 for which beta-decay rates have the greatest effect on weak and main r-process abundance patterns, we apply the finite-amplitude method (FAM) with Skyrme energy-density functionals (EDFs) to calculate beta-decay half-lives of those nuclei in the quasiparticle random-phase approximation (QRPA). We use the equal filling approximation to extend our implementation of the charge-changing FAM, which incorporates pairing correlations and allows axially symmetric deformation, to odd-A and odd-odd nuclei. Within this framework we find differences of up to a factor of seven between our calculated beta-decay half-lives and those of previous efforts. Repeated calculations with nuclei near A = 160 and multiple EDFs show a spread of two to four in beta-decay half-lives, with differences in calculated Q values playing an important role. We investigate the implications of these results for r-process simulations.

  14. Application of R software in Experiment Design and Data Processing Teaching%R软件在《试验设计与数据处理》教学中的应用

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

      R软件是一款功能强大、易于使用的免费开源统计计算软件,可使用于多种平台。R软件具有完整的数据载入、编辑、试验设计、统计分析和图形制作等功能。在《试验设计与数据处理》课程教学中,将R软件作为教学辅助工具,可激发学生学习的积极性,显著提高教学质量。%R is one of the most popular platforms for data analysis and visualization currently available. It is free, open-source software, with versions for Windows, Mac OS X, and Linux operating systems. R software has complete data input, editing, experiment design, statistical analysis, graphics, and other functions. It can act as auxiliary teaching tools in the course of experiment design and data processing, which can stimulate student's study enthusiasm, improve the ability of students to master the knowledge of experiment design and data processing and improve teaching quality obviously.

  15. eddy4R 0.2.0: a DevOps model for community-extensible processing and analysis of eddy-covariance data based on R, Git, Docker, and HDF5

    Directory of Open Access Journals (Sweden)

    S. Metzger

    2017-08-01

    Full Text Available Large differences in instrumentation, site setup, data format, and operating system stymie the adoption of a universal computational environment for processing and analyzing eddy-covariance (EC data. This results in limited software applicability and extensibility in addition to often substantial inconsistencies in flux estimates. Addressing these concerns, this paper presents the systematic development of portable, reproducible, and extensible EC software achieved by adopting a development and systems operation (DevOps approach. This software development model is used for the creation of the eddy4R family of EC code packages in the open-source R language for statistical computing. These packages are community developed, iterated via the Git distributed version control system, and wrapped into a portable and reproducible Docker filesystem that is independent of the underlying host operating system. The HDF5 hierarchical data format then provides a streamlined mechanism for highly compressed and fully self-documented data ingest and output. The usefulness of the DevOps approach was evaluated for three test applications. First, the resultant EC processing software was used to analyze standard flux tower data from the first EC instruments installed at a National Ecological Observatory (NEON field site. Second, through an aircraft test application, we demonstrate the modular extensibility of eddy4R to analyze EC data from other platforms. Third, an intercomparison with commercial-grade software showed excellent agreement (R2  =  1.0 for CO2 flux. In conjunction with this study, a Docker image containing the first two eddy4R packages and an executable example workflow, as well as first NEON EC data products are released publicly. We conclude by describing the work remaining to arrive at the automated generation of science-grade EC fluxes and benefits to the science community at large. This software development model is applicable beyond EC

  16. Introduction to probability with R

    CERN Document Server

    Baclawski, Kenneth

    2008-01-01

    FOREWORD PREFACE Sets, Events, and Probability The Algebra of Sets The Bernoulli Sample Space The Algebra of Multisets The Concept of Probability Properties of Probability Measures Independent Events The Bernoulli Process The R Language Finite Processes The Basic Models Counting Rules Computing Factorials The Second Rule of Counting Computing Probabilities Discrete Random Variables The Bernoulli Process: Tossing a Coin The Bernoulli Process: Random Walk Independence and Joint Distributions Expectations The Inclusion-Exclusion Principle General Random Variable

  17. Data wrangling with R

    CERN Document Server

    Boehmke, Ph D , Bradley C

    2016-01-01

    This guide for practicing statisticians, data scientists, and R users and programmers will teach the essentials of preprocessing: data leveraging the R programming language to easily and quickly turn noisy data into usable pieces of information. Data wrangling, which is also commonly referred to as data munging, transformation, manipulation, janitor work, etc., can be a painstakingly laborious process. Roughly 80% of data analysis is spent on cleaning and preparing data; however, being a prerequisite to the rest of the data analysis workflow (visualization, analysis, reporting), it is essential that one become fluent and efficient in data wrangling techniques. This book will guide the user through the data wrangling process via a step-by-step tutorial approach and provide a solid foundation working with data in R. The author's goal is to teach the user how to easily wrangle data in order to spend more time on understanding the content of the data. By the end of the book, the user will have learned: How to wor...

  18. Evolution of Seismic Velocities in Heavy Oil Sand Reservoirs during Thermal Recovery Process Évolution des vitesses sismiques dans les réservoirs de sables bitumineux au cours des procédés de récupération thermique

    Directory of Open Access Journals (Sweden)

    Nauroy J.-F.

    2013-01-01

    Full Text Available In thermally enhanced recovery processes like Cyclic Steam Stimulation (CSS or Steam Assisted Gravity Drainage (SAGD, continuous steam injection entails changes in pore fluid, pore pressure and temperature in the rock reservoir, that are most often unconsolidated or weakly consolidated sandstones. This in turn increases or decreases the effective stresses and changes the elastic properties of the rocks. Thermally enhanced recovery processes give rise to complex couplings. 4D seismic surveys are currently conducted to delineate the steam-affected areas but the interpretation is difficult. However, it is essential for optimization of reservoir development. Numerical simulations have been carried out on a case study so as to provide an estimation of the evolution of pressure, temperature, pore fluid saturation, stress and strain in any zone located around the injector and producer wells. The approach of Ciz and Shapiro (2007 (Geophysics 72, A75-A79 has been used to model the velocity dispersion in the oil sand mass under different conditions of temperature and stress. A good agreement has been found between these predictions and some laboratory velocity measurements carried out on samples of Canadian oil sand. Results appear to be useful to better interpret 4D seismic data in order to locate the steam chamber. Dans les procédés de récupération des huiles lourdes par méthodes thermiques, comme ia stimulation cyclique par vapeur (CSS ou le drainage par gravité assisté par vapeur (SAGD, l’injection de vapeur en continu entraîne des changements de liquide de pores, de pression interstitielle et de température dans la roche réservoir, qui est constituée le plus souvent de sable non consolidés ou faiblement consolidés- Ces changements à leur tour augmentent ou diminuent les contraintes effectives et modifient les propriétés élastiques des roches. Les procédés de récupération par méthodes thermiques mettent en oeuvre des couplages

  19. Mutation of EMG1 causing Bowen-Conradi syndrome results in reduced cell proliferation rates concomitant with G2/M arrest and 18S rRNA processing delay.

    Science.gov (United States)

    Armistead, Joy; Hemming, Richard; Patel, Nehal; Triggs-Raine, Barbara

    2014-06-01

    Bowen-Conradi syndrome (BCS) is a lethal autosomal recessive disorder caused by a D86G substitution in the protein, Essential for Mitotic Growth 1 (EMG1). EMG1 is essential for 18S rRNA maturation and 40S ribosome biogenesis in yeast, but no studies of its role in ribosome biogenesis have been done in mammals. To assess the effect of the EMG1 mutation on cell growth and ribosomal biogenesis in humans, we employed BCS patient cells. The D86G substitution did not interfere with EMG1 nucleolar localization. In BCS patient lymphoblasts, cells accumulated in G2/M, resulting in reduced proliferation rates; however, patient fibroblasts showed normal proliferation. The rate of 18S rRNA processing was consistently delayed in patient cells, although this did not lead to a difference in the levels of 40S ribosomes, or a change in protein synthesis rates. These results demonstrate that as in yeast, EMG1 in mammals has a role in ribosome biogenesis. The obvious phenotype in lymphoblasts compared to fibroblasts suggests a greater need for EMG1 in rapidly dividing cells. Tissue-specific effects have been seen in other ribosomal biogenesis disorders, and it seems likely that the impact of EMG1 deficiency would be larger in the rapidly proliferating cells of the developing embryo.

  20. Mutation of EMG1 causing Bowen–Conradi syndrome results in reduced cell proliferation rates concomitant with G2/M arrest and 18S rRNA processing delay

    Directory of Open Access Journals (Sweden)

    Joy Armistead

    2014-06-01

    Full Text Available Bowen–Conradi syndrome (BCS is a lethal autosomal recessive disorder caused by a D86G substitution in the protein, Essential for Mitotic Growth 1 (EMG1. EMG1 is essential for 18S rRNA maturation and 40S ribosome biogenesis in yeast, but no studies of its role in ribosome biogenesis have been done in mammals. To assess the effect of the EMG1 mutation on cell growth and ribosomal biogenesis in humans, we employed BCS patient cells. The D86G substitution did not interfere with EMG1 nucleolar localization. In BCS patient lymphoblasts, cells accumulated in G2/M, resulting in reduced proliferation rates; however, patient fibroblasts showed normal proliferation. The rate of 18S rRNA processing was consistently delayed in patient cells, although this did not lead to a difference in the levels of 40S ribosomes, or a change in protein synthesis rates. These results demonstrate that as in yeast, EMG1 in mammals has a role in ribosome biogenesis. The obvious phenotype in lymphoblasts compared to fibroblasts suggests a greater need for EMG1 in rapidly dividing cells. Tissue-specific effects have been seen in other ribosomal biogenesis disorders, and it seems likely that the impact of EMG1 deficiency would be larger in the rapidly proliferating cells of the developing embryo.

  1. Geostatistical Methods in R

    Directory of Open Access Journals (Sweden)

    Adéla Volfová

    2012-10-01

    Full Text Available Geostatistics is a scientific field which provides methods for processing spatial data.  In our project, geostatistics is used as a tool for describing spatial continuity and making predictions of some natural phenomena. An open source statistical project called R is used for all calculations. Listeners will be provided with a brief introduction to R and its geostatistical packages and basic principles of kriging and cokriging methods. Heavy mathematical background is omitted due to its complexity. In the second part of the presentation, several examples are shown of how to make a prediction in the whole area of interest where observations were made in just a few points. Results of these methods are compared.

  2. Modern optimization with R

    CERN Document Server

    Cortez, Paulo

    2014-01-01

    The goal of this book is to gather in a single document the most relevant concepts related to modern optimization methods, showing how such concepts and methods can be addressed using the open source, multi-platform R tool. Modern optimization methods, also known as metaheuristics, are particularly useful for solving complex problems for which no specialized optimization algorithm has been developed. These methods often yield high quality solutions with a more reasonable use of computational resources (e.g. memory and processing effort). Examples of popular modern methods discussed in this book are: simulated annealing; tabu search; genetic algorithms; differential evolution; and particle swarm optimization. This book is suitable for undergraduate and graduate students in Computer Science, Information Technology, and related areas, as well as data analysts interested in exploring modern optimization methods using R.

  3. Fission properties for r-process nuclei

    CERN Document Server

    Erler, J; Loens, H P; Martínez-Pinedo, G; Reinhard, P -G

    2011-01-01

    We present a systematics of fission barriers and fission lifetimes for the whole landscape of super-heavy elements (SHE), i.e. nuclei with Z>100. The fission lifetimes are also compared with the alpha-decay half-lives. The survey is based on a self-consistent description in terms of the Skyrme-Hartree-Fock (SHF) approach. Results for various different SHF parameterizations are compared to explore the robustness of the predictions. The fission path is computed by quadrupole constrained SHF. The computation of fission lifetimes takes care of the crucial ingredients of the large-amplitude collective dynamics along the fission path, as self-consistent collective mass and proper quantum corrections. We discuss the different topologies of fission landscapes which occur in the realm of SHE (symmetric versus asymmetric fission, regions of triaxial fission, bi-modal fission, and the impact of asymmetric ground states). The explored region is extended deep into the regime of very neutron-rich isotopes as they are expec...

  4. Study of the damage processes induced by thermal fatigue in stainless steels F17TNb and R20-12 for automobile application; Etude de l'endommagement en fatigue thermique des aciers inoxydables F17TNb et R20-12 pour application automobile

    Energy Technology Data Exchange (ETDEWEB)

    Bucher, L.

    2004-12-15

    Thermal cycling is the main cause of fatigue failure in automobile exhaust manifolds for which the use of stainless steel now rivals that of cast iron which has been traditionally used. An original fatigue test has been developed by Ugine and ALZ, a stainless steel producer, so as to be able to compare different grades of stainless steel alloys. This test is representative of the thermal conditions encountered in the critical zones of exhaust manifolds. However, it has revealed significant differences in damage processes in the ferritic and austenitic grades tested. The subject of this thesis is the damage processes induced by thermal fatigue in stainless steels used for automotive exhaust manifolds. Two stainless steels were studied: a ferritic grade, F17TNb (17%Cr and stabilized with Ti and Nb), and an austenitic grade, R20-12, containing 20% Cr and 12% Ni. The first objective was to understand the different damage processes induced by thermal fatigue in the ferritic and austenitic grades. The second was to develop a numerical design tool of the thermally tested structures. (author)

  5. 用精益六西格玛方法完善某T/R组件生产工艺%T/R Module Production Process Optimization Using Lean 6 Sigma Method

    Institute of Scientific and Technical Information of China (English)

    汤俊; 傅涛

    2013-01-01

    本文介绍了精益生产和六西格玛的基本含义及特点,通过精益生产和六西格玛管理的对比分析,指出了实施精益六西格玛的必要性和可行性。针对我所某T/R组件生产工艺中存在的实际问题,成立精益六西格玛绿带项目组,根据精益六西格玛的五个基本步骤,充分运用适宜的常用方法和工具,改进、完善了该产品T/R组件生产工艺,大大缩短了调试时间,取得了较好的经济效益,达到了预期的目标。%The concept and characteristic of lean production and 6 sigma method is introduced in the paper. Lean production and 6 sigma management is contrastively analyzed, which is indicated that it is necessary and feasible for introducing lean 6 sigma into mass production. Aiming at actual problems in T/R module production process, 6 sigma management group was setup, and based on 6 sigma five basic analysis approach, methods and tools were adequately used in the study. T/R module production process was improved and optimized, which decreased tuning time. Great economic benefit is gained, and expectant target is achieved.

  6. R/2R DAC Nonlinearity Compensation

    OpenAIRE

    Kulig, Gabriel; Wallin, Gustav

    2012-01-01

    The resistor ladder (R/2R) digital-to-analogue converter (DAC) architecture is often used in high performance audio solutions due to its low-noise performance. Even high-end R/2R DACs suffer from static nonlinearity distortions. It was suspected that compensating for these nonlinearities would be possible. It was also suspected that this could improve audio quality in audio systems using R/2R DACs for digital-to-analogue (A/D) conversion. Through the use of models of the resistor ladder archi...

  7. R quick syntax reference

    CERN Document Server

    Tollefson, Margot

    2014-01-01

    The R Quick Syntax Reference is a handy reference book detailing the intricacies of the R language. Not only is R a free, open-source tool, R is powerful, flexible, and has state of the art statistical techniques available. With the many details which must be correct when using any language, however, the R Quick Syntax Reference makes using R easier.Starting with the basic structure of R, the book takes you on a journey through the terminology used in R and the syntax required to make R work. You will find looking up the correct form for an expression quick and easy. With a copy of the R Quick

  8. 75 FR 68970 - Amendment of Using Agency for Restricted Areas R-4002, R-4005, R-4006 and R-4007; MD

    Science.gov (United States)

    2010-11-10

    ... Restricted Areas R-4002, R-4005, R- 4006 and R-4007; MD AGENCY: Federal Aviation Administration (FAA), DOT... restricted areas R-4002, Bloodsworth Island, MD; and R-4005, R-4006 and R-4007, Patuxent River, MD to ``U.S... areas R-4002, R-4005, R-4006 and R-4007 in Maryland, in order to reflect the correct......

  9. Learning data mining with R

    CERN Document Server

    Makhabel, Bater

    2015-01-01

    This book is intended for the budding data scientist or quantitative analyst with only a basic exposure to R and statistics. This book assumes familiarity with only the very basics of R, such as the main data types, simple functions, and how to move data around. No prior experience with data mining packages is necessary; however, you should have a basic understanding of data mining concepts and processes.

  10. Physical and chemical data collected by bottle and CTD in the Gulf of Mexico from the R/V Gyre and R/V Pelican, April 2004 - July 2009 to help resolve the dominant oceanographic processes that control the timing, duration, and severity of hypoxia of the region (NCEI Accession 0088164)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Physical and chemical oceanographic observational data collected by bottle and CTD in the Gulf of Mexico from the R/V Gyre and R/V Pelican, April 2004 - July 2009....

  11. R Basics with Tabular Data

    Directory of Open Access Journals (Sweden)

    Taryn Dewar

    2016-12-01

    Full Text Available As more and more historical records are digitized, having a way to quickly analyze large volumes of tabular data makes research faster and more effective. R is a programming language with strengths in statistical analyses. As such, it can be used to complete quantitative analysis on historical sources, including but not limited to statistical tests. Because you can repeatedly re-run the same code on the same sources, R lets you analyze data quickly and produces repeatable results. Because you can save your code, R lets you re-purpose or revise functions for future projects, making it a flexible part of your toolkit. This tutorial presumes no prior knowledge of R. It will go through some of the basic functions of R and serves as an introduction to the language. It will take you through the installation process, explain some of the tools that you can use in R, as well as explain how to work with data sets while doing research. The tutorial will do so by going through a series of mini-lessons that will show the kinds of sources R works well with and examples of how to do calculations to find information that could be relevant to historical research. The lesson will also cover different input methods for R such as matrices and using CSV files.

  12. System performance with R407A, R407B, R407C compared to R22

    DEFF Research Database (Denmark)

    Knudsen, Hans Jørgen Høgaard

    1997-01-01

    The paper presents the results obtained by substituting R22 with mixtures of R32/R124/134a (R407A, R407B and R407C) in an existing refrigeration plant. The cooling water flow and cooling water inlet temperature together with the brine flow and brine inlet temperature have been kept on a value...... been determined.The results show that for R407C both the cooling capacity and the COP are smaller than the cooling capacity and COP for R22. The cooling capacity for R407A and for R407B is lower then the cooling capacity for R22 for brine temperatures less than 0 C and higher than the capacity for R22...

  13. RSEIS and RFOC: Seismic Analysis in R

    Science.gov (United States)

    Lees, J. M.

    2015-12-01

    Open software is essential for reproducible scientific exchange. R-packages provide a platform for development of seismological investigation software that can be properly documented and traced for data processing. A suite of R packages designed for a wide range of seismic analysis is currently available in the free software platform called R. R is a software platform based on the S-language developed at Bell Labs decades ago. Routines in R can be run as standalone function calls, or developed in object-oriented mode. R comes with a base set of routines, and thousands of user developed packages. The packages developed at UNC include subroutines and interactive codes for processing seismic data, analyzing geographic information (GIS) and inverting data involved in a variety of geophysical applications. On CRAN (Comprehensive R Archive Network, http://www.r-project.org/) currently available packages related to seismic analysis are RSEIS, Rquake, GEOmap, RFOC, zoeppritz, RTOMO, and geophys, Rwave, PEIP, hht, rFDSN. These include signal processing, data management, mapping, earthquake location, deconvolution, focal mechanisms, wavelet transforms, Hilbert-Huang Transforms, tomographic inversion, and Mogi deformation among other useful functionality. All software in R packages is required to have detailed documentation, making the exchange and modification of existing software easy. In this presentation, I will focus on packages RSEIS and RFOC, showing examples from a variety of seismic analyses. The R approach has similarities to the popular (and expensive) MATLAB platform, although R is open source and free to down load.

  14. Les villes frontalières thaïlandaises dans la régionalisation Thai Bordertowns in the Regionalization Process: Spatial Planing and Production of New Urban Forms

    Directory of Open Access Journals (Sweden)

    Elsa Lainé

    2013-04-01

    Full Text Available La ville frontalière apparaît comme un type urbain particulier, tant en raison de sa localisation que de ses fonctions. Cet article propose d’étudier les villes frontalières thaïlandaises, et plus précisément celles situées sur les corridors de développement mis en place dans le cadre de la coopération régionale. Si ces villes sont longtemps apparues comme des espaces périphériques, peu intégrés au territoire national, deux dynamiques contemporaines modifient cet état de fait : le mouvement de déconcentration initié par le gouvernement thaïlandais dès le milieu des années 1970 d’une part, et surtout la coopération régionale marquant le tournant des années 1990 d’autre part. Les villes frontalières thaïlandaises sont devenues depuis une vingtaine d’années des objets spécifiques de la planification gouvernementale. D’espaces périphériques, elles ont été promues gateways, pôles de croissance économiques et soutien au commerce avec les pays limitrophes. Même si leur place dans le tissu urbain national diverge encore largement, des projets d’infrastructures leur permet d’acquérir une nouvelle envergure. L’étude de cas de trois villes sélectionnées montrent que si elles diffèrent au regard de critères démographiques, économiques ou en termes d’équipements, ces villes ont toutes connu au cours des dernières années et sous l’effet combiné de la régionalisation et de la planification une modification de leur organisation spatiale. De nouveaux centres apparaissent, et la diversité des acteurs impliqués ainsi que les dynamiques en cours sont à même de modifier de manière variable les relations entretenues avec les centres urbains situés de l’autre côté de la frontière d’une part, et la place de ces villes frontalières thaïlandaises dans le tissu urbain national et régional d’autre part.This paper will focus on Thai bordertowns located on ADB economic corridors. The

  15. 76 FR 72869 - Proposed Establishment of Restricted Areas R-5402, R-5403A, R-5403B, R-5403C, R-5403D, R-5403E...

    Science.gov (United States)

    2011-11-28

    ... Federal Aviation Administration 14 CFR Part 73 Proposed Establishment of Restricted Areas R-5402, R-5403A, R- 5403B, R-5403C, R-5403D, R-5403E, and R-5403F; Devils Lake, ND AGENCY: Federal Aviation... Camp Grafton Range, the existing R-5401 restricted area surrounding the range is inadequate to...

  16. Process-Costing, Job-Order-Costing, Operation Costing (også kaldet Batch Costing og Functional Costing - Når Systemtankegangen ligger til grund for økonomistyringen og dens beslutninger)

    DEFF Research Database (Denmark)

    Nielsen, Steen

    2005-01-01

    De tre begreber process-costing, job-order-costing, operation-costing samt functional-based costing er faktisk historiske begreber som stammer langt tilbage i økonomistyringslitteraturen, faktisk tilbage til Scientific Management bevægelsen fra 20'erne og 30'erne. Man kan derfor ikke sige, at disse...... Aktivitets-Baseret Cost Management systemerne. Det er derfor vigtigt dels at kende sin historie på området, dels at gøre sig klart, om de under visse antagelser stadig har deres berettigelse. De samme begreber har også deres pendant til de danske begreber, afdelings- eller funktionsregnskabet samt...... ordreregnskabet, f.eks. som dette er analyseret hos Palle Hansen og Vagn Madsen. Begrebet operational costing anvendes også, men dette dækker i realiteten over, hvordan og hvilke elementer der indgår i hele virksomhedens regnskabs-information-system. Dvs. at dette mere er et spørgsmål om, hvordan systemerne er...

  17. J. R. R. Tolkien. A Marxist Reading

    OpenAIRE

    Stefán Gestur Stefánsson 1982

    2014-01-01

    J. R. R. Tolkien is a world renowned writer that is credited with the revival of the fantasy genre with his hobbit driven epics. His works have sold in the hundreds of millions and his novels have been transposed to films and comics which have been successful in their own right. With such exposure it is inevitable for his works to exert an influence on its audience. To criticize Tolkien’s work with the aim of getting a fuller understanding of both the author J. R. R. Tolkien and his works cal...

  18. R in a nutshell

    CERN Document Server

    Adler, Joseph

    2010-01-01

    Why learn R? Because it's rapidly becoming the standard for developing statistical software. R in a Nutshell provides a quick and practical way to learn this increasingly popular open source language and environment. You'll not only learn how to program in R, but also how to find the right user-contributed R packages for statistical modeling, visualization, and bioinformatics. The author introduces you to the R environment, including the R graphical user interface and console, and takes you through the fundamentals of the object-oriented R language. Then, through a variety of practical examp

  19. ITIL (R) - General Overview

    OpenAIRE

    Jašek, Roman; Králík, Lukáš; Nožička, Jakub

    2015-01-01

    The paper presents the reader into the issue of ITIL (R) and provides it as a basic overview of the concepts, terminology and philosophyof IT Service management. All this information is contained in 5 key ITIL (R) publications on around 1400 pages. The aim therefore is a brief summary of the issue, which also serves as an introduction to the following articles (Differences Between ITIL (R) v2 and ITIL (R) v3, ITIL (R) and Information Security, ITIL (R) Tools and ITIL (R) Implementation).

  20. ITIL (R) - General Overview

    OpenAIRE

    Jašek, Roman; Králík, Lukáš; Nožička, Jakub

    2015-01-01

    The paper presents the reader into the issue of ITIL (R) and provides it as a basic overview of the concepts, terminology and philosophyof IT Service management. All this information is contained in 5 key ITIL (R) publications on around 1400 pages. The aim therefore is a brief summary of the issue, which also serves as an introduction to the following articles (Differences Between ITIL (R) v2 and ITIL (R) v3, ITIL (R) and Information Security, ITIL (R) Tools and ITIL (R) Implementation).

  1. FINAL REPORT DETERMINATION OF THE PROCESSING RATE OF RPP WTP HLW SIMULANTS USING A DURAMELTER J 1000 VITRIFICATION SYSTEM VSL-00R2590-2 REV 0 8/21/00

    Energy Technology Data Exchange (ETDEWEB)

    KRUGER AA; MATLACK KS; KOT WK; PEREZ-CARDENAS F; PEGG IL

    2011-12-29

    This report provides data, analysis, and conclusions from a series of tests that were conducted at the Vitreous State Laboratory of The Catholic University of America (VSL) to determine the melter processing rates that are achievable with RPP-WTP HLW simulants. The principal findings were presented earlier in a summary report (VSL-00R2S90-l) but the present report provides additional details. One of the most critical pieces of information in determining the required size of the RPP-WTP HLW melter is the specific glass production rate in terms of the mass of glass that can be produced per unit area of melt surface per unit time. The specific glass production rate together with the waste loading (essentially, the ratio of waste-in to glass-out, which is determined from glass formulation activities) determines the melt area that is needed to achieve a given waste processing rate with due allowance for system availability. As a consequence of the limited amount of relevant information, there exists, for good reasons, a significant disparity between design-base specific glass production rates for the RPP-WTP LAW and HLW conceptual designs (1.0 MT/m{sup 2}/d and 0.4 MT/m{sup 2}/d, respectively); furthermore, small-scale melter tests with HLW simulants that were conducted during Part A indicated typical processing rates with bubbling of around 2.0 MT/m{sup 2}/d. This range translates into more than a factor of five variation in the resultant surface area of the HLW melter, which is clearly not without significant consequence. It is clear that an undersized melter is undesirable in that it will not be able to support the required waste processing rates. It is less obvious that there are potential disadvantages associated with an oversized melter, over and above the increased capital costs. A melt surface that is consistently underutilized will have poor cold cap coverage, which will result in increased volatilization from the melt (which is generally undesirable) and

  2. β -Decay Half-Lives of 110 Neutron-Rich Nuclei across the N=82 Shell Gap: Implications for the Mechanism and Universality of the Astrophysical r Process

    Energy Technology Data Exchange (ETDEWEB)

    Lorusso, G.; Nishimura, S.; Xu, Z. Y.; Jungclaus, A.; Shimizu, Y.; Simpson, G. S.; Söderström, P. -A.; Watanabe, H.; Browne, F.; Doornenbal, P.; Gey, G.; Jung, H. S.; Meyer, B.; Sumikama, T.; Taprogge, J.; Vajta, Zs.; Wu, J.; Baba, H.; Benzoni, G.; Chae, K. Y.; Crespi, F. C. L.; Fukuda, N.; Gernhäuser, R.; Inabe, N.; Isobe, T.; Kajino, T.; Kameda, D.; Kim, G. D.; Kim, Y. -K.; Kojouharov, I.; Kondev, F. G.; Kubo, T.; Kurz, N.; Kwon, Y. K.; Lane, G. J.; Li, Z.; Montaner-Pizá, A.; Moschner, K.; Naqvi, F.; Niikura, M.; Nishibata, H.; Odahara, A.; Orlandi, R.; Patel, Z.; Podolyák, Zs.; Sakurai, H.; Schaffner, H.; Schury, P.; Shibagaki, S.; Steiger, K.; Suzuki, H.; Takeda, H.; Wendt, A.; Yagi, A.; Yoshinaga, K.

    2015-05-01

    The β -decay half-lives of 110 neutron-rich isotopes of the elements from Rb 37 to Sn 50 were measured at the Radioactive Isotope Beam Factory. The 40 new half-lives follow robust systematics and highlight the persistence of shell effects. The new data have direct implications for r -process calculations and reinforce the notion that the second (A≈130 ) and the rare-earth-element (A≈160 ) abundance peaks may result from the freeze-out of an (n,γ)⇌(γ,n) equilibrium. In such an equilibrium, the new half-lives are important factors determining the abundance of rare-earth elements, and allow for a more reliable discussion of the r process universality. It is anticipated that universality may not extend to the elements Sn, Sb, I, and Cs, making the detection of these elements in metal-poor stars of the utmost importance to determine the exact conditions of individual r -process events.

  3. Practical experience with R32 mixtures as replacement substances for R22 and R502; Praxiserfahrungen mit R32-Gemischen als Austauschstoffe fuer R22 und R502

    Energy Technology Data Exchange (ETDEWEB)

    Schwennesen, K. [Deutsche ICI GmbH, Frankfurt am Main (Germany)

    1995-12-31

    Like R11 and R12, the refrigerant R502 will soon belong to the past and the steps for the prohibition of use of R22 have already been taken. Due to both its thermo-physical properties and its relatively low greenhouse gas potential, R32 is an important part of replacement refrigerants compatible with the ozone layer for both R22 and R502. There is a report on practical experience with R407A and R407C here. (orig.) [Deutsch] Das Kaeltemittel R 502 wird, wie R 11 und R 12, in naechster Zukunft der Vergangenheit angehoeren und auch fuer R 22 sind die Schritte zu Verwendungsverboten bereits festgelegt. R 32 ist sowohl aufgrund seiner thermophysikalischen Eigenschaften als auch wegen seines relative niedrigen Treibhauspotentials eine bedeutende Komponente in ozonvertraeglichen Austauschkaeltemitteln sowohl fuer R 22 als uach fuer R 502. Ueber Praxiserfahrungen mit R 407A und R 407C wird hier berichtet. (orig.)

  4. 1,2-Dichlorohexafluoro-Cyclobutane (1,2-c-C4F6Cl2, R-316c) a Potent Ozone Depleting Substance and Greenhouse Gas: Atmospheric Loss Processes, Lifetimes, and Ozone Depletion and Global Warming Potentials for the (E) and (Z) stereoisomers

    Science.gov (United States)

    Papadimitriou, Vassileios C.; McGillen, Max R.; Smith, Shona C.; Jubb, Aaron M.; Portmann, Robert W.; Hall, Bradley D.; Fleming, Eric L.; Jackman, Charles H.; Burkholder, James B.

    2013-01-01

    The atmospheric processing of (E)- and (Z)-1,2-dichlorohexafluorocyclobutane (1,2-c-C4F6Cl2, R-316c) was examined in this work as the ozone depleting (ODP) and global warming (GWP) potentials of this proposed replacement compound are presently unknown. The predominant atmospheric loss processes and infrared absorption spectra of the R-316c isomers were measured to provide a basis to evaluate their atmospheric lifetimes and, thus, ODPs and GWPs. UV absorption spectra were measured between 184.95 to 230 nm at temperatures between 214 and 296 K and a parametrization for use in atmospheric modeling is presented. The Cl atom quantum yield in the 193 nm photolysis of R- 316c was measured to be 1.90 +/- 0.27. Hexafluorocyclobutene (c-C4F6) was determined to be a photolysis co-product with molar yields of 0.7 and 1.0 (+/-10%) for (E)- and (Z)-R-316c, respectively. The 296 K total rate coefficient for the O(1D) + R-316c reaction, i.e., O(1D) loss, was measured to be (1.56 +/- 0.11) × 10(exp -10)cu cm/ molecule/s and the reactive rate coefficient, i.e., R-316c loss, was measured to be (1.36 +/- 0.20) × 10(exp -10)cu cm/molecule/s corresponding to a approx. 88% reactive yield. Rate coefficient upper-limits for the OH and O3 reaction with R-316c were determined to be global annually averaged lifetimes for the (E)- and (Z)-R-316c isomers were calculated using a 2-D atmospheric model to be 74.6 +/- 3 and 114.1 +/-10 years, respectively, where the estimated uncertainties are due solely to the uncertainty in the UV absorption spectra. Stratospheric photolysis is the predominant atmospheric loss process for both isomers with the O(1D) reaction making a minor, approx. 2% for the (E) isomer and 7% for the (Z) isomer, contribution to the total atmospheric loss. Ozone depletion potentials for (E)- and (Z)-R-316c were calculated using the 2-D model to be 0.46 and 0.54, respectively. Infrared absorption spectra for (E)- and (Z)-R-316c were measured at 296 K and used to estimate their

  5. 94 {beta}-Decay Half-Lives of Neutron-Rich 55Cs to 67Ho: Experimental Feedback and Evaluation of the r-Process Rare-Earth Peak Formation

    Energy Technology Data Exchange (ETDEWEB)

    Wu, J.; Nishimura, S.; Lorusso, G.; Moller, P; Ideguchi, E; Regan, P. H.; Simpson, G. S.; Soderstrom, P. -A.; Walker, P. M.; Watanabe, H.; Kondev, F. G.

    2017-02-17

    The β-decay half-lives of 94 neutron-rich nuclei 144$-$151Cs, 146$-$154Ba, 148$-$156La, 150$-$158Ce, 153$-$160Pr, 156$-$162Nd, 159$-$163Pm, 160$-$166Sm, 161$-$168Eu, 165$-$170Gd, 166$-$172Tb, 169$-$173Dy, 172$-$175Ho, and two isomeric states 174mEr, 172mDy were measured at the Radioactive Isotope Beam Factory, providing a new experimental basis to test theoretical models. Strikingly large drops of β-decay half-lives are observed at neutron-number N = 97 for 58Ce, 59Pr, 60Nd, and 62Sm, and N = 105 for 63Eu, 64Gd, 65Tb, and 66Dy. Lastly, features in the data mirror the interplay between pairing effects and microscopic structure. r-process network calculations performed for a range of mass models and astrophysical conditions show that the 57 half-lives measured for the first time play an important role in shaping the abundance pattern of rare-earth elements in the solar system

  6. Repercussões satíricas dos processos de escolarização do social nas ondas do rádio (1930-1940 Satirical repercussions of the social schooling processes in radio programs (1930-1940

    Directory of Open Access Journals (Sweden)

    Maria Angela Borges Salvadori

    2012-12-01

    Full Text Available Este artigo analisa repercussões satíricas dos processos de escolarização do social no Brasil, presentes em antigos programas humorísticos de rádio, que, geralmente organizados pelo diálogo entre um professor e seus alunos, foram simultaneamente grandes sucessos em termos de audiência e alvos de uma crítica sistemática por parte daqueles que defendiam a radiodifusão como instrumento de divulgação da "verdadeira" cultura. Por meio do uso de fontes sonoras e impressas, objetiva compreender as razões do sucesso do gênero e, neste percurso, identificar as críticas à escola, à educação e seus sujeitos, que, jocosamente, veicularam, explicitadas em conflitos entre sonoras tradições populares e saberes escolares.This article analyzes satirical repercussions of the social schooling processes in Brazil found in old radio comedies which, usually built around the dialogue between a teacher and his or her students, were, on the one hand, huge audience successes and, on the other hand, subjected to systematic criticism from those who believed that radio broadcasting should be used as an instrument to disseminate the "true" culture. Through the use of sound and print records, the text seeks to understand the reasons behind the success of this genre and, in so doing, to identify the criticisms that these programs directed through humor at the school, at education and its agents, which were brought forward in conflicts between sonorous popular traditions and school knowledge.

  7. (R)-1,1'-联萘手性单元通过溶胶凝胶法合成杂化硅干凝胶%Silica Hybrid Xerogel Incorporating (R)-2,2'-bis(methoxyethoxymethyloxy)- 1,1'-binaphthyl Unit via Sol-Gel Process

    Institute of Scientific and Technical Information of China (English)

    成义祥; 宋金峰; 陈令武; 邹小伟

    2005-01-01

    Precursor molecule (R)-6,6'-bis(triethoxysilylethen-2-yl)-2,2'-di(methoxyethoxymethyloxy)-1,1'-binaph-thyl (R-2) was synthesized by Pd-catalyzed Heck reaction of (R)-6,6'-dibromo-2,2'-di(methoxyethoxymethyloxy)-1,1'-binaphthyl (R-1) intermediate with vinyltriethoxysilane. The hydrolysis and polycondensation of the precursorR-2 produced the corresponding xerogel. Both precursor and xerogel were analysed by NMR, FTIR, UV, CDspectra, fluorescent spectroscopy, polarimetry and elemental analysis. The precursor and xerogel can emit strongblue fluorescence and are expected to have a potential application in the separation of chiral molecules as fluo-rescent sensor. The precursor exhibits strong Cotton effect in its circular dichroism (CD) spectrum indicating ahighly rigid structure.

  8. FINAL REPORT DETERMINATION OF THE PROCESSING RATE OF RPP WTP HLW SIMULANTS USING A DURAMELTER J 1000 VITRIFICATION SYSTEM VSL-00R2590-2 REV 0 8/21/00

    Energy Technology Data Exchange (ETDEWEB)

    KRUGER AA; MATLACK KS; KOT WK; PEREZ-CARDENAS F; PEGG IL

    2011-12-29

    This report provides data, analysis, and conclusions from a series of tests that were conducted at the Vitreous State Laboratory of The Catholic University of America (VSL) to determine the melter processing rates that are achievable with RPP-WTP HLW simulants. The principal findings were presented earlier in a summary report (VSL-00R2S90-l) but the present report provides additional details. One of the most critical pieces of information in determining the required size of the RPP-WTP HLW melter is the specific glass production rate in terms of the mass of glass that can be produced per unit area of melt surface per unit time. The specific glass production rate together with the waste loading (essentially, the ratio of waste-in to glass-out, which is determined from glass formulation activities) determines the melt area that is needed to achieve a given waste processing rate with due allowance for system availability. As a consequence of the limited amount of relevant information, there exists, for good reasons, a significant disparity between design-base specific glass production rates for the RPP-WTP LAW and HLW conceptual designs (1.0 MT/m{sup 2}/d and 0.4 MT/m{sup 2}/d, respectively); furthermore, small-scale melter tests with HLW simulants that were conducted during Part A indicated typical processing rates with bubbling of around 2.0 MT/m{sup 2}/d. This range translates into more than a factor of five variation in the resultant surface area of the HLW melter, which is clearly not without significant consequence. It is clear that an undersized melter is undesirable in that it will not be able to support the required waste processing rates. It is less obvious that there are potential disadvantages associated with an oversized melter, over and above the increased capital costs. A melt surface that is consistently underutilized will have poor cold cap coverage, which will result in increased volatilization from the melt (which is generally undesirable) and

  9. Does R&D pay?

    Science.gov (United States)

    Cavalla, David; Minhas, Raman

    2010-03-01

    Pharmaceutical R&D is notoriously risky, lengthy and costly; moreover, it does not always produce products of blockbuster status. The conventional route of fully discovering, developing and marketing a new chemical entity is followed by the large pharmaceutical companies, whereas other organizations in the pharmaceutical sector--such as generic or specialty companies and biotechnology companies--only operate over portions of the full R&D process. Here, we compare the ten-year financial performance of these three subsectors through their price/earnings ratios and their return on capital metrics to understand which of these strategic alternatives offered the best return to investors.

  10. Beginning data science with R

    CERN Document Server

    Pathak, Manas A

    2014-01-01

    “Data Science with R” deals with implementing many useful data analysis methodologies with the R programming language. The target audience for this book is non-R programmers and non-statisticians. The book will cover all the necessary concepts from the basics to state-of-the-art technologies like working with big data. The author attempts to strike a balance between the “how”: specific processes and methodologies, while also talking about the “why”: giving an intuition behind how a particular technique works, so that the reader can apply the generalized solution to the problem at hand.

  11. R graphs cookbook

    CERN Document Server

    Abedin, Jaynal

    2014-01-01

    Targeted at those with an existing familiarity with R programming, this practical guide will appeal directly to programmers interested in learning effective data visualization techniques with R and a wide-range of its associated libraries.

  12. Metaprogramming in R

    DEFF Research Database (Denmark)

    Mailund, Thomas

    2017-01-01

    Learn how to manipulate functions and expressions to modify how the R language interprets itself. This book is an introduction to metaprogramming in the R language, so you will write programs to manipulate other programs. Metaprogramming in R shows you how to treat code as data that you can...

  13. Factor Analysis Using "R"

    Science.gov (United States)

    Beaujean, A. Alexander

    2013-01-01

    "R" (R Development Core Team, 2011) is a very powerful tool to analyze data, that is gaining in popularity due to its costs (its free) and flexibility (its open-source). This article gives a general introduction to using "R" (i.e., loading the program, using functions, importing data). Then, using data from Canivez, Konold, Collins, and Wilson…

  14. Factor Analysis Using "R"

    Science.gov (United States)

    Beaujean, A. Alexander

    2013-01-01

    "R" (R Development Core Team, 2011) is a very powerful tool to analyze data, that is gaining in popularity due to its costs (its free) and flexibility (its open-source). This article gives a general introduction to using "R" (i.e., loading the program, using functions, importing data). Then, using data from Canivez, Konold, Collins, and Wilson…

  15. 圈4C 的(r1,r2,r3,r4)−冠的优美性%The gracefulness of the (r1, r2, r3, r4)−corona of the cycle 4C

    Institute of Scientific and Technical Information of China (English)

    吴跃生

    2012-01-01

      讨论了圈4C 的( r r 21,,, r r 43)−冠的优美性,用构造性的方法给出了圈4C 的( r r 21,,, r r 43)−冠的优美标号。证明了圈4C 的( r r 21,,, r r 43)−冠都是交错图。%  Discussed the gracefulness of the( r r 2 1 , , , r r 4 3 )−corona of the cycle 4C .The graceful labeling was given.Proved that the( r r 2 1 , , , r r 4 3 )−corona of the cycle 4C are graceful graph.

  16. Captive R&D Offshoring

    DEFF Research Database (Denmark)

    Søberg, Peder Veng

    This PhD thesis includes four journal papers and one book chapter, which investigate how newly established foreign-invested R&D units in emerging markets become able to carry out their mandates. In particular, the author investigates how the employees of such units acquire R&D home base knowledge...... Scandinavia and now operating in Scandinavia, China, and India. The thesis questions an assumption in the Uppsala model, which implies that different business activities can be internationalized in the same way. The findings point to the importance of socialization across the R&D home base and newly...... that the local talent in China and India is particularly suited to improving existing products and processes. However, due to a lack of social initiative, it is more difficult to use this talent to identify and solve entirely new problems. The thesis also investigates how local sources of knowledge are engaged...

  17. Analysis of the processes of R and D in generating innovation of new technology-based firms in science and technology parks; Analisis de los procesos de I+D en la generacion de innovacion de las nuevas empresas de base tecnologica en parques cientificos y tecnologicos

    Energy Technology Data Exchange (ETDEWEB)

    Bueno Campos, E.; Acosta Prado, J. C.; Longo Somoza, M.

    2010-07-01

    This paper identifies the R and D processes and technological capabilities of the New Technology-Based Firms (NTBFs) created at Madrid Science Park and Leganes Technologic Science Park located in Madrid (Spain). The empirical study is carried out through an inductive deductive methodology. The results have allowed us to describe the processes and capabilities and also the relationships between them. A relevant set of managerial implications are finally derived from the research. (Author) 64 refs.

  18. Data manipulation with R

    CERN Document Server

    Abedin, Jaynal

    2014-01-01

    This book is a step-by step, example-oriented tutorial that will show both intermediate and advanced users how data manipulation is facilitated smoothly using R.This book is aimed at intermediate to advanced level users of R who want to perform data manipulation with R, and those who want to clean and aggregate data effectively. Readers are expected to have at least an introductory knowledge of R and some basic administration work in R, such as installing packages and calling them when required.

  19. Data Mashups in R

    CERN Document Server

    Leipzig, Jeremy

    2009-01-01

    This article demonstrates how the realworld data is imported, managed, visualized, and analyzed within the R statistical framework. Presented as a spatial mashup, this tutorial introduces the user to R packages, R syntax, and data structures. The user will learn how the R environment works with R packages as well as its own capabilities in statistical analysis. We will be accessing spatial data in several formats-html, xml, shapefiles, and text-locally and over the web to produce a map of home foreclosure auctions and perform statistical analysis on these events.

  20. At R207

    CERN Multimedia

    1975-01-01

    At the centre, a barrel shaped hodoscope surrounds the beams' crossing point. It was previously used for experiments R205 and R206 which did run in 1974. After their completion in mid 1975 the equipment of R205 was removed, and that of R206 was modified and rearranged to create two small angle spectrometers, one on each side of the intersection, for experiment R207 (diffraction dissociation and formation at small momentum transfer), by the CERN-Holland-Manchester Collaboration. (see also photos 7508109X and 7508113X) Here on the right, Lars Leistam.