Kidspiration[R] for Inquiry-Centered Activities

Science.gov (United States)

Shaw, Edward L., Jr.; Baggett, Paige V.; Salyer, Barbara

2004-01-01

Computer technology can be integrated into science inquiry activities to increase student motivation and enhance and expand scientific thinking. Fifth-grade students used the visual thinking tools in the Kidspiration[R] software program to generate and represent a web of hypotheses around the question, "What affects the distance a marble rolls?"…

Microsoft System Center 2012 R2 compliance management cookbook

CERN Document Server

Baumgarten, Andreas; Roesner, Susan

2014-01-01

Whether you are an IT manager, an administrator, or security professional who wants to learn how Microsoft Security Compliance Manager and Microsoft System Center can help fulfil compliance and security requirements, this is the book for you. Prior knowledge of Microsoft System Center is required.

A comparison of R-22, R-134a, R-410a, and R-407c condensation performance in smooth and enhanced tubes: Part 1, Heat transfer

Energy Technology Data Exchange (ETDEWEB)

Eckels, S J; Tesene, B A

1999-07-01

Local and average heat transfer coefficients during condensation are reported for R-22, R-134a, R-410a, and R-407c in one smooth tube and three enhanced surface tubes. The test tubes included a 3/8 inch outer diameter smooth tube, a 3/8 inch outer diameter microfin tube, a 5/16 inch outer diameter microfin tube, and a 5/8 inch outer diameter microfin tube. The local and average heat transfer coefficients were measured over a mass flux range of 92,100 lb/ft{sup 2}{center_dot}h to 442,200 lb/ft{sup 2}{center_dot}h and at saturation temperatures of 104 F and 122 F. A comparison of the performance of the different refrigerants reveals that R-134a has the highest heat transfer performance followed by R-22 and R-410a, which have similar performances. In general, R-407c had the lowest performance of the refrigerants tested. The microfin tube more than doubles the heat transfer coefficient compared to the smooth tube for all refrigerants at the low mass fluxes, but only increases the heat transfer coefficients by 50% at the highest mass flux tested. The measured heat transfer coefficients are also compared with a number of correlations for condensation.

The Soviet center of astronomical data

International Nuclear Information System (INIS)

Dluzhnevskaya, O.B.

1982-01-01

On the basis of the current French-Soviet cooperation in science and technology, the Astronomical Council of the U.S.S.R. Academy of Sciences and the Strasbourg Center signed in 1977 an agreement on setting up the Soviet Center of Astronomical Data as its filial branch. The Soviet Center was created on the basis of a computation center at the Zvenigorod station of the Astronomical Council of the U.S.S.R. Academy of Sciences, which had already had considerable experience of working with stellar catalogues. In 1979 the Center was equipped with a EC-1033 computer. In 1978-1979 the Soviet Center of Astronomical Data (C.A.D.) received from Strasbourg 96 of the most important catalogues. By September 1981 the list of catalogues available at the Soviet Center has reached 140 catalogues some of which are described. (Auth.)

Subgroups of GLn(R) for local rings R

International Nuclear Information System (INIS)

Kuku, A.O.; Mahdavi-Hezavehi, M.

2002-07-01

Let R be a local ring, with maximal ideal m, and residue class division ring R/m=D. Put A=M n (R)-n≥1, and denote by A*=GL n (R) the group of units of A. Here we investigate some algebraic structure of subnormal and maximal subgroups of A * . For instance, when D is of finite dimension over its center, it is shown that finitely generated subnormal subgroups of A* are central. It is also proved that maximal subgroups of A* are not finitely generated. Furthermore, assume that P is a nonabelian maximal subgroup of GL 1 (R) such that P contains a noncentral soluble normal subgroup of finite index, it is shown that D is a crossed product division algebra. (author)

Determinants of U.S. poison center utilization.

Science.gov (United States)

Litovitz, Toby; Benson, Blaine E; Youniss, Jessica; Metz, Edward

2010-06-01

High poison center utilization has been associated with decreased emergency department usage and hospitalization rates. However, utilization requires awareness of the poison center. Penetrance, defined as the number of human poison exposures reported to a poison center per 1,000 population, has been used as a marker of poison center awareness. To identify factors that influence poison center penetrance to optimize the life- and cost-saving benefits of poison control centers. Human poison exposures that were reported to the National Poison Data System in 2001 were analyzed to identify and rank factors affecting poison center penetrance. Overall penetrance correlated with pediatric penetrance (R(2) = 0.75, p poison center that were already in or en route to a healthcare facility at the time of the call to the poison center (R(2) = 0.41, p poison center service populations were associated with lower penetrance (R(2) = 0.23, p poison center (multiple regression). Positive predictors included the percentage of the population younger than 5 years, the percentage of the adult population with a bachelor's degree, poison center certification, poison center educator FTEs (full time equivalents), Asian population percentage, and population density. The inverse correlation between pediatric penetrance and healthcare facility utilization supports prior observations of excessive healthcare utilization when a poison center is not called. Since race, language and distance are barriers to poison center utilization, and since healthcare utilization increases when poison center penetrance declines, low penetrance suggests a lack of awareness of the poison center rather than a low incidence of poisonings. Strategies to raise penetrance should be informed by an understanding of the barriers to utilization - language, Black/African American race, distance from the poison center, poverty, and lower education levels.

Center for beam physics 1996-1997

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-02-01

The Center for Beam Physics (CBP) is a multidisciplinary research and development unit in the Accelerator and Fusion Research Division at the Ernest Orlando Lawrence Berkeley National Laboratory of the University of California. At the heart of the Center`s mission is the fundamental quest for mechanisms of acceleration, radiation, transport, and focusing of energy and information. Special features of the Center`s program include addressing R&D issues needing long development time and providing a platform for conception, initiation, and support of institutional projects based on beams. The Center brings to bear a significant amount of diverse, complementary, and self-sufficient expertise in accelerator physics, synchrotron radiation, advanced microwave techniques, plasma physics, optics, and lasers on the forefront R&D issues in particle and photon beam research. In addition to functioning as a clearinghouse for novel ideas and concepts and related R&D (e.g., various theoretical and experimental studies in beam physics such as nonlinear dynamics, phase space control, laser-beam-plasma interaction, free-electron lasers, optics, and instrumentation), the Center provides significant support to Laboratory facilities and initiatives. This roster and annual report provides a glimpse of the scientists, engineers, technical support, students, and administrative staff that make up the CBP`s outstanding team and gives a flavor of their multifaceted activities during 1996 and 1997.

Carl Rogers: Body-Centered Counselor.

Science.gov (United States)

Fernald, Peter S.

2000-01-01

C. R. Rogers' approach is examined in the context of person-centered theories of personality and counseling. Identifies similarities between Rogers' thinking and W. Reich's theories in body-oriented psychotherapy. Discusses film-recorded interview conducted by Rogers, which demonstrates his body-centered approach. (Author/JDM)

TÜRKİYE’DE KURULMASI PLANLANAN LOJİSTİK MERKEZLER HAKKINDA BİR ANALİZ ÇALIŞMASI - AN ANALYSIS OF THE PLANNED LOGISTICS CENTERS IN TURKEY

Directory of Open Access Journals (Sweden)

Bülent SEZEN

2014-08-01

Full Text Available ÖzetKüreselleşme ile birlikte artan ticaret eğilimleri beraberinde lojistik faaliyetlerin ve lojistik sektörününönemini her geçen gün biraz daha arttırmaktadır. Lojistik merkez kavramı ortaya atılıp uygulamayageçmesinden sonra sağladığı üstünlükler nedeniyle hızla yaygınlaşmaya başladığı gözlenmiştir. Avrupa’dabugün sayıları 80’yi aşan lojistik merkezler gerek ulusal gerek uluslararası ölçekte işletilmekte ve çoksayıda yeni lojistik merkez planlama ve inşa aşamasında bulunmaktadır. Ülkemizde TCDD tarafından18 Lojistik Merkez yapılması planlanmaktadır. Bu merkezlerin yerleri ve özellikleri belirlenmiştir.Merkezlerin başarılı olması yönetimlerinin başarılı olmasına ve dünyadaki örneklerinden kazanılantecrübelerle sağlanabilir. Araştırmamızda derinlemesine mülakat tekniği ve kapalı uçlu anket çalışması ileyönetim modellerini ve yaşanabilecek sorunları inceledik.AbstractIncreasing world trade along with the globalization increases logistics activities. After the introductionof the concept of logistics center it has been observed that they disseminated rapidly mainly because ofmany advantages they provided. Today, in Europe, more than 80 logistics centers are in operation atnational or international scale; many more are being planned or being constructed. In our country 18logistics centers are planned to be built by TCDD. Their locations and capabilities are already determined.The success of logistics centers depends on successful management and learning from the experiences ofthe good examples in the world. We use in-depth interview techniques and structured survey methods in this research to find out which management models may best suit to the logistics centers in Turkey andwhat kind of problems may arise in the process.

World Trade Center

Index Scriptorium Estoniae

2006-01-01

Esilinastus katastroofifilm "World Trade Center" : stsenarist Andrea Berloff : režissöör Oliver Stone : kunstnik Jan Roelfs : osades Nicholas Cage, Michael Pena, Stephen Dorff jpt : Ameerika Ühendriigid 2006. Ka filmi prototüüpidest

Rapport for Center for Vildtsundhed 1. halvår 2012

DEFF Research Database (Denmark)

Chriél, Mariann; Enemark, Heidi L.; Therkildsen, Ole Roland

for vurderingen af parasitbelastningen hos raske ederfugle. Redemateriale til undersøgelse af Pasteurella multocida, der forårsager udbrud af fjerkrækolera, fortsættes i et specialestudie af de dyrkbare bakterier. Med henblik på kortlægning af rævens dværgbændelorm (Echinococcus multilocularis) hos mårhund og ræv...... Danmark siden 2000, og det er første gang bændelormen er påvist i jyske ræve. Echinococcus multilocularis kan smitte til mennesker, hvor de i larvestadiet angriber leveren, hvilket kan have fatale følger, så det er vigtigt, at folk er opmærksomme på risikoen og tager deres forbehold. Mennesker smittes...

Center for beam physics 1996-1997

International Nuclear Information System (INIS)

1997-02-01

The Center for Beam Physics (CBP) is a multidisciplinary research and development unit in the Accelerator and Fusion Research Division at the Ernest Orlando Lawrence Berkeley National Laboratory of the University of California. At the heart of the Center's mission is the fundamental quest for mechanisms of acceleration, radiation, transport, and focusing of energy and information. Special features of the Center's program include addressing R ampersand D issues needing long development time and providing a platform for conception, initiation, and support of institutional projects based on beams. The Center brings to bear a significant amount of diverse, complementary, and self-sufficient expertise in accelerator physics, synchrotron radiation, advanced microwave techniques, plasma physics, optics, and lasers on the forefront R ampersand D issues in particle and photon beam research. In addition to functioning as a clearinghouse for novel ideas and concepts and related R ampersand D (e.g., various theoretical and experimental studies in beam physics such as nonlinear dynamics, phase space control, laser-beam-plasma interaction, free-electron lasers, optics, and instrumentation), the Center provides significant support to Laboratory facilities and initiatives. This roster and annual report provides a glimpse of the scientists, engineers, technical support, students, and administrative staff that make up the CBP's outstanding team and gives a flavor of their multifaceted activities during 1996 and 1997

A first attempt : k-center

Indian Academy of Sciences (India)

First page Back Continue Last page Overview Graphics. A first attempt : k-center. Randomly select R= C x k points. expected C points from the “largest cluster”. Consider all C-points subsets of R. (at least one will be “purely” from largest cluster). Centroid of this will approximate cluster centre.

JAEA FBR Plant Engineering Center annual report 2011

International Nuclear Information System (INIS)

2012-11-01

The FBR Plant Engineering Center was established on April 1, 2009 located in a research building, of which care is taken by the International Nuclear Information Training Center, Tsuruga Head Office, at Shiraki in Tsuruga. The mission of the center is to perform R and D (research and development) works both for analysis of operational experiences at the prototype fast breeder reactor “Monju” and for technology development concerning design and operation of “Monju”. Moreover it is also required to apply the results to next generation fast breeder reactors, which is an important role of Advanced Nuclear System Research and Development Directorate. And in these R and D activities, it is expected to conduct the works in cooperation with domestic or foreign research organizations or universities by a joint-study or a collaborative-work manner. The R and D activities have been carried out specifically on the “demonstration of the reliability as a power generation plant” and “establishment of sodium handling technology”, which are originally intended missions of “Monju”. And the other R and Ds have been promoted both for the plant engineering, such as plant maintenance, to effectively use an existing reactor in order to apply the R and D results to a future demonstration reactor, and for the irradiation test study, such as advanced fuel irradiation, to use “Monju” as an irradiation test bed. In order to perform these R and D activities, five R and D groups have been set up in the center. They are operation-and-maintenance engineering, sodium engineering, reactor-core-and-fuel engineering, plant engineering, and safety engineering groups. However, the Japanese atomic energy policy is being reviewed after the accident of the Fukushima Daiichi nuclear power station caused by a tsunami generated by the Tohoku-district-off-the-Pacific-Ocean Earthquake on March 11, 2011, and all the R and D activities using “Monju” have been suspended since late 2011

R and T report: Goddard Space Flight Center

Science.gov (United States)

Soffen, Gerald A. (Editor)

1993-01-01

The 1993 Research and Technology Report for Goddard Space Flight Center is presented. Research covered areas such as (1) flight projects; (2) space sciences including cosmology, high energy, stars and galaxies, and the solar system; (3) earth sciences including process modeling, hydrology/cryology, atmospheres, biosphere, and solid earth; (4) networks, planning, and information systems including support for mission operations, data distribution, advanced software and systems engineering, and planning/scheduling; and (5) engineering and materials including spacecraft systems, material and testing, optics and photonics and robotics.

Annual report of R and D activities in center for promotion of computational science and engineering from April 1, 2004 to March 31, 2005

International Nuclear Information System (INIS)

2005-09-01

This report provides an overview of research and development activities in Center for Promotion of Computational Science and Engineering (CCSE), JAERI, in the fiscal year 2004 (April 1, 2004 - March 31, 2005). The activities have been performed by Research Group for Computational Science in Atomic Energy, Research Group for Computational Material Science in Atomic Energy, R and D Group for Computer Science, R and D Group for Numerical Experiments, and Quantum Bioinformatics Group in CCSE. The ITBL (Information Technology Based Laboratory) project is performed mainly by the R and D Group for Computer Science and the Research Group for Computational Science in Atomic Energy. According to the mid-term evaluation for the ITBL project conducted by the MEXT, the achievement of the ITBL infrastructure software developed by JAERI has been remarked as outstanding at the 13th Information Science and Technology Committee in the Subdivision on R and D Planning and Evaluation of the Council for Science and Technology on April 26th, 2004. (author)

R&D Characteristics and Organizational Structure: Case Studies of University-Industry Research Centers

Science.gov (United States)

Hart, Maureen McArthur

2013-01-01

Within the past few decades, university-industry research centers have been developed in large numbers and emphasized as a valuable policy tool for innovation. Yet little is known about the heterogeneity of organizational structure within these centers, which has implications regarding policy for and management of these centers. This dissertation…

(2S,4R-2-[(1R-1-(4-Bromophenyl-2-nitroethyl]-4-ethylcyclohexanone

Directory of Open Access Journals (Sweden)

Chi-Xiao Zhang

2013-02-01

Full Text Available The crystal structure of the title compound, C16H20BrNO3, contains three chiral centers in the configuration 1R,2S,6R. The cyclohexane ring is in a chair conformation. In the crystal, molecules are linked by weak C—H...O interactions, forming chains along the a-axis direction.

R&D Subsidiary Mandates of Western MNEs in China:

DEFF Research Database (Denmark)

Schulzmann, David; Slepniov, Dmitrij

2016-01-01

The number of Western MNCs established R&D centers in China has been rising from the year 2000 starting with under 200 centers to over 1300 centers by the end of 2010 (Stanley, Yang, & Ritacca, 2013). These developments followed increased Foreign Direct Investment (FDI) to China, underpinned...... in the world (Motohashi, 2012). These R&D investments to a large extent are flowing into technological parks with good supporting infrastructure in Beijing, Shanghai, Guangzhou and Shenzhen (Stanley et al., 2013; Walsh, 2007). Aside from the lucrative advantages of offshoring R&D to China, there are numerous...... was primarily focused on development and product adaptation to the local market (Lundin & Serger, 2007), rather than conducting new basic research which could be applied globally across the MNC (Bartlett & Ghoshal, 1998; Govindarajan & Trimble, 2012). Overtime, some R&D subsidiaries evolved and achieved...

Stellar configurations in f(R) theories of gravity

International Nuclear Information System (INIS)

Henttunen, K.; Multamaeki, T.; Vilja, I.

2008-01-01

We study stellar configurations and the space-time around them in metric f(R) theories of gravity. In particular, we focus on the polytropic model of the Sun in two specific cases: the f(R)=R-μ 4 /R model and a model with a stabilizing higher order term f(R)=R-μ 4 /R+βR 3 /(3μ 4 ). We show how the stellar configuration in the f(R) theory can, by appropriate initial conditions, be selected to be equal to that described by the Lane-Emden equation and how a simple scaling relation exists between the solutions. We also derive the correct solution analytically near the center of the star in f(R) theory. Previous analytical and numerical results are confirmed, indicating that the space-time around the Sun is incompatible with solar system constraints in the f(R)=R-μ 4 /R model. Numerical work shows that stellar configurations, with a regular metric at the center, lead to γ PPN ≅1/2 outside the star for both models, i.e., the Schwarzschild-de Sitter space-time is not the correct vacuum solution for such configurations. This shows that even when one fine-tunes the initial conditions inside a star such that the mass of the effective scalar in the equivalent scalar-tensor theory is large, γ PPN is still 1/2 outside the star. Conversely, by selecting the Schwarzschild-de Sitter metric as the outside solution, or equivalently setting the mass of the effective scalar to be large outside the star, we find that the stellar configuration is unchanged but the metric is irregular at the center. The possibility of constructing a f(R) theory compatible with the solar system experiments and possible new constraints arising from the radius-mass relation of stellar objects is discussed

Mutations in 23S rRNA at the Peptidyl Transferase Center and Their Relationship to Linezolid Binding and Cross-Resistance

DEFF Research Database (Denmark)

Long, Katherine; Munck, Christian

2010-01-01

The oxazolidinone antibiotic linezolid targets the peptidyl transferase center (PTC) on the bacterial ribosome. Thirteen single and four double 23S rRNA mutations were introduced into a Mycobacterium smegmatis strain with a single rRNA operon. Converting bacterial base identity by single mutations...... at positions 2032, 2453, and 2499 to human cytosolic base identity did not confer significantly reduced susceptibility to linezolid. The largest decrease in linezolid susceptibility for any of the introduced single mutations was observed with the G2576U mutation at a position that is 7.9 Å from linezolid....... Smaller decreases were observed with the A2503G, U2504G, and G2505A mutations at nucleotides proximal to linezolid, showing that the degree of resistance conferred is not simply inversely proportional to the nucleotide-drug distance. The double mutations G2032A-C2499A, G2032A-U2504G, C2055A-U2504G, and C...

ACToR - Aggregated Computational Toxicology Resource

International Nuclear Information System (INIS)

Judson, Richard; Richard, Ann; Dix, David; Houck, Keith; Elloumi, Fathi; Martin, Matthew; Cathey, Tommy; Transue, Thomas R.; Spencer, Richard; Wolf, Maritja

2008-01-01

ACToR (Aggregated Computational Toxicology Resource) is a database and set of software applications that bring into one central location many types and sources of data on environmental chemicals. Currently, the ACToR chemical database contains information on chemical structure, in vitro bioassays and in vivo toxicology assays derived from more than 150 sources including the U.S. Environmental Protection Agency (EPA), Centers for Disease Control (CDC), U.S. Food and Drug Administration (FDA), National Institutes of Health (NIH), state agencies, corresponding government agencies in Canada, Europe and Japan, universities, the World Health Organization (WHO) and non-governmental organizations (NGOs). At the EPA National Center for Computational Toxicology, ACToR helps manage large data sets being used in a high-throughput environmental chemical screening and prioritization program called ToxCast TM

Annual report of R and D activities in Center for Computational Science and e-Systems from April 1, 2009 to March 31, 2010

International Nuclear Information System (INIS)

2011-10-01

This report overviews the activity of research and development (R and D) in Center for Computational Science and e-Systems (CCSE) of the Japan Atomic Energy Agency (JAEA), during the fiscal year 2009 (April 1, 2009 - March 31, 2010). The work has been accomplished by the Simulation Technology R and D Office and Computer Science R and D Office in CCSE. The activity includes researches of secure computational infrastructure for the use in atomic energy research, which is based on the grid technology, a seismic response analysis for the structure of nuclear power plants, materials science, and quantum bioinformatics. The materials science research includes large scale atomic and subatomic simulations of nuclear fuels and materials for safety assessment, large scale quantum simulations of superconductor for the design of new devices and fundamental understanding of superconductivity. The quantum bioinformatics research focuses on the development of technology for large scale atomic simulations of proteins. (author)

On the center of distances

Czech Academy of Sciences Publication Activity Database

Bielas, Wojciech; Plewik, S.; Walczyńska, Marta

2018-01-01

Roč. 4, č. 2 (2018), s. 687-698 ISSN 2199-675X R&D Projects: GA ČR GF16-34860L Institutional support: RVO:67985840 Keywords : Cantorval center of distances von Neumann's theorem * set of subsums Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics https://link.springer.com/article/10.1007%2Fs40879-017-0199-4

Activity report of Computing Research Center

Energy Technology Data Exchange (ETDEWEB)

1997-07-01

On April 1997, National Laboratory for High Energy Physics (KEK), Institute of Nuclear Study, University of Tokyo (INS), and Meson Science Laboratory, Faculty of Science, University of Tokyo began to work newly as High Energy Accelerator Research Organization after reconstructing and converting their systems, under aiming at further development of a wide field of accelerator science using a high energy accelerator. In this Research Organization, Applied Research Laboratory is composed of four Centers to execute assistance of research actions common to one of the Research Organization and their relating research and development (R and D) by integrating the present four centers and their relating sections in Tanashi. What is expected for the assistance of research actions is not only its general assistance but also its preparation and R and D of a system required for promotion and future plan of the research. Computer technology is essential to development of the research and can communize for various researches in the Research Organization. On response to such expectation, new Computing Research Center is required for promoting its duty by coworking and cooperating with every researchers at a range from R and D on data analysis of various experiments to computation physics acting under driving powerful computer capacity such as supercomputer and so forth. Here were described on report of works and present state of Data Processing Center of KEK at the first chapter and of the computer room of INS at the second chapter and on future problems for the Computing Research Center. (G.K.)

Techniques for trans-catheter retrieval of embolized Nit-Occlud® PDA-R and ASD-R devices.

Science.gov (United States)

Sinha, Sanjay; Levi, Daniel; Peirone, Alejandro; Pedra, Carlos

2018-02-15

Nit-Occlud ® (atrial septal defect) ASD-R and (patent ductus arteriosus) PDA-R devices are used outside the United States for percutaneous closure of the patent ductus arteriosus and atrial septal defects. When embolization occurs, these devices have been difficult to retrieve. Bench simulations of retrieval of PDA-R and ASD-R devices were performed in a vascular model. Retrieval of each device was attempted using snare techniques or with bioptome forceps with a range of devices. The same devices were then intentionally embolized in an animal model. Retrieval methods were systematically tested in a range of sheath sizes, and graded in terms of difficulty and retrieval time. Devices that were grasped by the bioptome in the center of the proximal part of the devices were easily retrieved in both models. Bench studies determined the minimum sheath sizes needed for retrieval of each device with this method. In general sheathes two french sizes greater than the delivery sheath were successful with this technique. Three out of the four PDA-R devices were successfully retrieved in vivo. Two were retrieved by grasping the middle of the PA end of the PDA-R device with a Maslanka bioptome and one small PDA-R device was retrieved using a 10 mm Snare. Four of the five ASD-R devices were retrieved successfully grasping the right atrial ASD-R disc or by passing a wire through the device and snaring this loop. For ASD-R 28 and 30 mm devices, a double bioptome technique was needed to retrieve the device. ASD-R and PDA-R devices can be successfully retrieved in the catheterization lab. It is critical to grab the center portion of the right atrial disc of the ASD-R device or pulmonary portion of the PDA-R device and to use adequately sized sheathes. © 2018 Wiley Periodicals, Inc.

Transition of R&D into Operations at Fleet Numerical Meteorology and Oceanography Center

Science.gov (United States)

Clancy, R. M.

2006-12-01

The U.S. Navy's Fleet Numerical Meteorology and Oceanography Center (FNMOC) plays a significant role in the National capability for operational weather and ocean prediction through its operation of sophisticated global and regional meteorological and oceanographic models, extending from the top of the atmosphere to the bottom of the ocean. FNMOC uniquely satisfies the military's requirement for a global operational weather prediction capability based on software certified to DoD Information Assurance standards and operated in a secure classified computer environment protected from outside intrusion by DoD certified firewalls. FNMOC operates around-the-clock, 365 days per year and distributes products to military and civilian users around the world, both ashore and afloat, through a variety of means. FNMOC's customers include all branches of the Department of Defense, other government organizations such as the National Weather Service, private companies, a number of colleges and universities, and the general public. FNMOC employs three primary models, the Navy Operational Global Atmospheric Prediction System (NOGAPS), the Coupled Ocean/Atmosphere Mesoscale Prediction System (COAMPS), and the WaveWatch III model (WW3), along with a number of specialized models and related applications. NOGAPS is a global weather model, driving nearly all other FNMOC models and applications in some fashion. COAMPS is a high- resolution regional model that has proved to be particularly valuable for forecasting weather and ocean conditions in highly complex coastal areas. WW3 is a state-of-the-art ocean wave model that is employed both globally and regionally in support of a wide variety of naval operations. Other models support and supplement the main models with predictions of ocean thermal structure, ocean currents, sea-ice characteristics, and other data. Fleet Numerical operates at the leading edge of science and technology, and benefits greatly from collocation with its supporting

Emergency Operations Center ribbon cutting

Science.gov (United States)

2009-01-01

Center Director Gene Goldman and special guests celebrate the opening of the site's new Emergency Operations Center on June 2. Participants included (l t r): Steven Cooper, deputy director of the National Weather Service Southern Region; Tom Luedtke, NASA associate administrator for institutions and management; Charles Scales, NASA associate deputy administrator; Mississippi Gov. Haley Barbour; Gene Goldman, director of Stennis Space Center; Jack Forsythe, NASA assistant administrator for the Office of Security and Program Protection; Dr. Richard Williams, NASA chief health and medical officer; and Weldon Starks, president of Starks Contracting Company Inc. of Biloxi.

In-tube flow boiling of R-407C and R-407C/oil mixtures. Part 1: Microfin tube

Energy Technology Data Exchange (ETDEWEB)

Zuercher, O; Thome, J R; Favrat, D

1999-07-01

In-tube evaporation tests for R-407C and R-407C/oil are reported for a microfin tube. The tests were run at a nominal inlet pressure of 645 kPa (93.5 psia) at mass velocities of 100, 200 and 300 kg/(m{sup 2}{center{underscore}dot}s) (20.5, 41, and 61 lb/s{center{underscore}dot}ft{sup 2}) over nearly the entire vapor quality range. At similar operating conditions, pure R-407C performed similarly to previous pure R-134a tests at the highest mass velocity, but lower than R-134a for the other mass velocities. Any amount of oil tended to decrease local R-407C microfin heat transfer coefficients, especially at high vapor qualities were degradations of as much as 50% or more occurred. Two-phase pressure drops were increased by the presence of oil, especially at high vapor qualities. Buildup of the local oil mass fraction in the microfin test sections was observed at high vapor qualities, together with the formation of slowly flowing viscous liquid films, a phenomenon that became more acute at lower mass velocities.

The GOES-R Proving Ground: 2012 Update

Science.gov (United States)

Gurka, J.; Goodman, S. J.; Schmit, T.; Demaria, M.; Mostek, A.; Siewert, C.; Reed, B.

2011-12-01

The Geostationary Operational Environmental Satellite (GOES)-R will provide a great leap forward in observing capabilities, but will also offer a significant challenge to ensure that users are ready to exploit the vast improvements in spatial, spectral, and temporal resolutions. To ensure user readiness, forecasters and other users must have access to prototype advanced products well before launch, and have the opportunity to provide feedback to product developers and computing and communications managers. The operational assessment is critical to ensure that the end products and NOAA's computing and communications systems truly meet their needs in a rapidly evolving environment. The GOES-R Proving Ground (PG) engages the National Weather Service (NWS) forecast, watch and warning community and other agency users in pre-operational demonstrations of select products with GOES-R attributes (enhanced spectral, spatial, and temporal resolution). In the PG, developers and forecasters test and apply algorithms for new GOES-R satellite data and products using proxy and simulated data sets, including observations from current and future satellite instruments (MODIS, AIRS, IASI, SEVIRI, NAST-I, NPP/VIIRS/CrIS, LIS), lightning networks, and computer simulated products. The complete list of products to be evaluated in 2012 will be determined after evaluating results from experiments in 2011 at the NWS' Storm Prediction Center, National Hurricane Center, Aviation Weather Center, Ocean Prediction Center, Hydrometeorological Prediction Center, and from the six NWS regions. In 2012 and beyond, the PG will test and validate data processing and distribution systems and the applications of these products in operational settings. Additionally developers and forecasters will test and apply display techniques and decision aid tools in operational environments. The PG is both a recipient and a source of training. Training materials are developed using various distance training tools in

Multicenter R2* mapping in the healthy brain

DEFF Research Database (Denmark)

Ropele, Stefan; Wattjes, Mike P; Langkammer, Christian

2014-01-01

structures. METHODS: R2* mapping was performed in 81 healthy subjects in seven centers using different 3 T systems. R2* was calculated from a dual-echo gradient echo sequence and was assessed in several deep gray matter structures. The inter-scanner and inter-subject variability of R2* was calculated...

Clinorotation influences rDNA and NopA100 localization in nucleoli

Science.gov (United States)

Sobol, M. A.; González-Camacho, F.; Rodríguez-Vilariño, V.; Kordyum, E. L.; Medina, F. J.

The nucleolus is the transcription site of rRNA genes as well as the site of processing and initial packaging of their transcripts. The plant nucleolin homologue NopA100 is involved in the regulation of r-chromatin condensation/expansion and rDNA transcription as well as in rRNA processing. We have investigated with immunogold electron microscopy the location of nucleolar DNA and NopA100 in cress root meristematic cells grown under slow horizontal clinorotation, reproducing an important feature of microgravity, namely the absence of an orienting action of a gravity vector, compared to control conditions. We demonstrate redistribution of both rDNA and NopA100 in nucleolar subcomponents induced by clinorotation. Ribosomal DNA concentrated predominantly in fibrillar centers in the form of condensed r-chromatin inclusions and internal non condensed fibrils, redistributing from the dense fibrillar component and the transition zone between fibrillar centers and the dense fibrillar component, recognized as the loci of rDNA transcription. The content of NopA100 was much higher in the inner space of fibrillar centers and reduced in the dense fibrillar component as compared to the control. Based on these data, an effect of slow horizontal clinorotation in lowering the level of rDNA transcription as well as rRNA processing is suggested.

Galactic Center Minispiral: Interaction Modes of Neutron Stars

Czech Academy of Sciences Publication Activity Database

Zajaček, Michal; Karas, Vladimír; Kunneriath, Devaky

2015-01-01

Roč. 55, č. 3 (2015), s. 203-214 ISSN 1210-2709 R&D Projects: GA ČR GB14-37086G Institutional support: RVO:67985815 Keywords : galaxy center * individual objects * Sagittarius A Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics

Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR.

Science.gov (United States)

Kumaraswami, Muthiah; Newberry, Kate J; Brennan, Richard G

2010-04-30

The multidrug-binding transcription regulator BmrR from Bacillus subtilis is a MerR family member that binds to a wide array of cationic lipophilic toxins to activate the transcription of the multidrug efflux pump gene bmr. Transcription activation from the sigma(A)-dependent bmr operator requires BmrR to remodel the nonoptimal 19-bp spacer between the -10 promoter element and the -35 promoter element in order to facilitate productive RNA polymerase binding. Despite the availability of several structures of BmrR bound to DNA and drugs, the lack of a BmrR structure in its unliganded or apo (DNA free and drug free) state hinders our full understanding of the structural transitions required for DNA binding and transcription activation. Here, we report the crystal structure of the constitutively active, unliganded BmrR mutant BmrR(E253Q/R275E). Superposition of the ligand-free (apo BmrR(E253Q/R275E)) and DNA-bound BmrR structures reveals that apo BmrR must undergo significant rearrangement in order to assume the DNA-bound conformation, including an outward rotation of minor groove binding wings, an inward movement of helix-turn-helix motifs, and a downward relocation of pliable coiled-coil helices. Computational analysis of the DNA-free and DNA-bound structures reveals a flexible joint that is located at the center of the coiled-coil helices. This region, which is composed of residues 94 through 98, overlaps the helical bulge that is observed only in the apo BmrR structure. This conformational hinge is likely common to other MerR family members with large effector-binding domains, but appears to be missing from the smaller metal-binding MerR family members. Interestingly, the center-to-center distance of the recognition helices of apo BmrR is 34 A and suggests that the conformational change from the apo BmrR structure to the bmr operator-bound BmrR structure is initiated by the binding of this transcription activator to a more B-DNA-like conformation. (c) 2010 Elsevier

Rolling Deck to Repository (R2R): Technical Design - Experiences and Lessons (Invited)

Science.gov (United States)

Arko, R. A.; Carbotte, S. M.; Miller, S. P.; Chandler, C. L.; Ferrini, V.; Stocks, K.; Maffei, A. R.; Smith, S. R.; Bourassa, M. A.; McLean, S. J.; Alberts, J. C.

2009-12-01

The NSF-funded Rolling Deck to Repository (R2R) project envisions the academic research fleet as an integrated global observing system, with routine “underway” sensor data flowing directly from research vessels to a central shore-side repository. It is a complex endeavor involving many stakeholders - technicians at sea, data managers on shore, ship schedulers, clearance officers, funding agencies, National Data Centers, data synthesis projects, the science community, and the public - working toward a common goal of acquiring, documenting, archiving, evaluating, and disseminating high-quality scientific data. The technical design for R2R is guided by several key principles: 1) The data pipeline is modular, so that initial stages (e.g. inventory and review of data shipments, posting of catalog records and track maps) may proceed routinely for every cruise, while later stages (e.g. quality assessment and production of file-level metadata) may proceed at different rates for different data types; 2) Cruise documentation (e.g. sailing orders, review/release of data inventories, vessel profiles) is gathered primarily via an authenticated Web portal, linked with the UNOLS scheduling database to synchronize vocabularies and eliminate redundancies; and 3) Every data set will be documented and delivered to the appropriate National Data Center for long-term archiving and dissemination after proprietary holds are cleared, while R2R maintains a master cruise catalog that links all the data sets together. This design accommodates the diversity of instrument types, data volumes, and shipment schedules among fleet operators. During its pilot development period, R2R has solicited feedback at community workshops, UNOLS meetings, and conference presentations, including fleet-wide surveys of current practices and instrument inventories. Several vessel operators began submitting cruise data and documentation during the pilot, providing a test bed for database development and Web

The rôle of planetaria: The Library of Alexandria Planetarium Science Center

Science.gov (United States)

El-Mitaky, Hoda S.

2011-06-01

In ancient times the stars and the Moon were humans' only guide to cross the seas and explore the depths of the deserts. With the use of modern technological gadgets, and the increasingly light pollution, citizens of the world stopped looking at the heavens. How can planetaria play a rôle in reviving public interest in astronomy? How can the beauty of astronomy play a rôle in luring the youth to pursue a career in science? How can astronomy play a rôle in raising public awareness about preserving the environment? Moreover, how can astronomy play a rôle in the dialogue among civilisations?

Annual report of R and D activities in Center for Promotion of Computational Science and Engineering and Center for Computational Science and e-Systems from April 1, 2005 to March 31, 2006

International Nuclear Information System (INIS)

2007-03-01

This report provides an overview of research and development activities in Center for Computational Science and Engineering (CCSE), JAERI in the former half of the fiscal year 2005 (April 1, 2005 - Sep. 30, 2006) and those in Center for Computational Science and e-Systems (CCSE), JAEA, in the latter half of the fiscal year 2005(Oct 1, 2005 - March 31, 2006). In the former half term, the activities have been performed by 5 research groups, Research Group for Computational Science in Atomic Energy, Research Group for Computational Material Science in Atomic Energy, R and D Group for Computer Science, R and D Group for Numerical Experiments, and Quantum Bioinformatics Group in CCSE. At the beginning of the latter half term, these 5 groups were integrated into two offices, Simulation Technology Research and Development Office and Computer Science Research and Development Office at the moment of the unification of JNC (Japan Nuclear Cycle Development Institute) and JAERI (Japan Atomic Energy Research Institute), and the latter-half term activities were operated by the two offices. A big project, ITBL (Information Technology Based Laboratory) project and fundamental computational research for atomic energy plant were performed mainly by two groups, the R and D Group for Computer Science and the Research Group for Computational Science in Atomic Energy in the former half term and their integrated office, Computer Science Research and Development Office in the latter half one, respectively. The main result was verification by using structure analysis for real plant executable on the Grid environment, and received Honorable Mentions of Analytic Challenge in the conference 'Supercomputing (SC05)'. The materials science and bioinformatics in atomic energy research field were carried out by three groups, Research Group for Computational Material Science in Atomic Energy, R and D Group for Computer Science, R and D Group for Numerical Experiments, and Quantum Bioinformatics

Relating calls to US poison centers for potential exposures to medications to Centers for Disease Control and Prevention reporting of influenza-like illness.

Science.gov (United States)

Beauchamp, Gillian A; McKeown, Nathanael J; Rodriguez, Sergio; Spyker, Daniel A

2016-03-01

The Centers for Disease Control (CDC) monitors influenza like illness (ILI) and the National Poison Data System (NPDS) warehouses call data uploaded by US poison centers regarding reported exposures to medication. We examined the relationship between calls to poison centers regarding reported exposures to medications commonly used to treat ILI and weekly reports of ILI. The CDC reports ILI, by age group, for each of 10 Health and Human Services (HHS) regions. We examined NPDS summary data from calls reported to poison centers regarding reported exposures to acetaminophen, cough/cold medications, and promethazine, for the same weeks, age groups, and HHS regions for influenza seasons 2000-2013. ILI and NPDS exposures were examined using graphical plots, descriptive statistics, stepwise regression analysis, and Geographic Information Systems (GIS). About 5,101,841 influenza-like illness cases were reported to the CDC, and 2,122,940 calls regarding reported exposures to medications commonly used to treat ILI, were reported by poison centers to the NPDS over the 13 flu seasons. Analysis of stepwise models of the linear untransformed data involving 24 NPDS data groups and for 60 ILI measures, over the 13 influenza seasons, demonstrated that reported exposures to medications used to treat ILI correlated with reported cases of ILI with a median R(2 )=( )0.489 (min R(2 )=( )0.248, max R(2 )=( )0.717), with mean ± SD of R(2 )=( )0.494 ± 0.121. Median number of parameters used (degrees of freedom - 1) was 7. NPDS data regarding poison center calls for selected ILI medication exposures were highly correlated with CDC ILI data. Since NPDS data are available in real time, it provides complimentary ILI monitoring. This approach may provide public health value in predicting other illnesses which are not currently as thoroughly monitored.

The R.I.R.S. scoring system: An innovative scoring system for predicting stone-free rate following retrograde intrarenal surgery.

Science.gov (United States)

Xiao, Yinglong; Li, Deng; Chen, Lei; Xu, Yaoting; Zhang, Dingguo; Shao, Yi; Lu, Jun

2017-11-21

To establish and internally validate an innovative R.I.R.S. scoring system that allows urologists to preoperatively estimate the stone-free rate (SFR) after retrograde intrarenal surgery (RIRS). This study included 382 eligible samples from a total 573 patients who underwent RIRS from January 2014 to December 2016. Four reproducible factors in the R.I.R.S. scoring system, including renal stone density, inferior pole stone, renal infundibular length and stone burden, were measured based on preoperative computed tomography of urography to evaluate the possibility of stone clearance after RIRS. The median cumulative diameter of the stones was 14 mm, and the interquartile range was 10 to 21. The SFR on postoperative day 1 in the present cohort was 61.5% (235 of 382), and the final SFR after 1 month was 73.6% (281 of 382). We established an innovative scoring system to evaluate SFR after RIRS using four preoperative characteristics. The range of the R.I.R.S. scoring system was 4 to 10. The overall score showed a great significance of stone-free status (p R.I.R.S. scoring system was 0.904. The R.I.R.S. scoring system is associated with SFR after RIRS. This innovative scoring system can preoperatively assess treatment success after intrarenal surgery and can be used for preoperative surgical arrangement and comparisons of outcomes among different centers and within a center over time.

Annual report of R and D activities in Center for Computational Science and e-Systems from April 1, 2007 to March 31, 2009

International Nuclear Information System (INIS)

2010-01-01

This report provides an overview of research and development activities in Center for Computational Science and e-Systems (CCSE), JAEA, during the fiscal years 2007 and 2008 (Apr 1, 2007 - March 31, 2009). These research and development activities have been performed by the Simulation Technology R and D Office and Computer Science R and D Office. These activities include development of secure computational infrastructure for atomic energy research based on the grid technology, large scale seismic analysis of an entire nuclear reactor structure, large scale fluid dynamics simulation of J-PARC mercury target, large scale plasma simulation for nuclear fusion reactor, large scale atomic and subatomic simulations of nuclear fuels and materials for safety assessment, large scale quantum simulations of superconductor for the design of new devices and fundamental understanding of superconductivity, development of protein database for the identification of radiation-resistance gene, and large scale atomic simulation of proteins. (author)

Stennis Space Center celebrates Native American culture

Science.gov (United States)

2009-01-01

Famie Willis (left), 2009-2010 Choctaw Indian Princess, displays artifacts during Native American Heritage Month activities at Stennis Space Center on Nov. 24. The celebration featured various Native American cultural displays for Stennis employees to view. Shown above are (l to r): Willis, Elaine Couchman of NASA Shared Services Center, John Cecconi of NSSC and Lakeisha Robertson of the Environmental Protection Agency.

O- centers in LuAG:Ce,Mg ceramics

Czech Academy of Sciences Publication Activity Database

Hu, C.; Liu, S.; Fasoli, M.; Vedda, A.; Nikl, Martin; Feng, X. Q.; Pan, Y.B.

2015-01-01

Roč. 9, č. 4 (2015), s. 245-249 ISSN 1862-6254 R&D Projects: GA ČR GAP204/12/0805 Institutional support: RVO:68378271 Keywords : scintillator * hole center * EPR * LuAG * Ce 3+ Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.578, year: 2015

Research on 6R Military Logistics Network

Science.gov (United States)

Jie, Wan; Wen, Wang

The building of military logistics network is an important issue for the construction of new forces. This paper has thrown out a concept model of 6R military logistics network model based on JIT. Then we conceive of axis spoke y logistics centers network, flexible 6R organizational network, lean 6R military information network based grid. And then the strategy and proposal for the construction of the three sub networks of 6Rmilitary logistics network are given.

Measurements of saturation densities in critical region and critical loci for binary R-32/125 and R-125/143a systems

Energy Technology Data Exchange (ETDEWEB)

Kishizawa, G.; Sato, H.; Watanabe, K.

1999-05-01

R-32/125 (difluoromethane/pentafluoroethane) and R-125/143a (pentafluoroethane/1,1,1-trifluoroethane) binary systems are promising alternative refrigerants to replace conventional refrigerants, i.e., R-22 and R-502. The saturated vapor- and liquid-density data in the critical region of these mixtures were measured using the visual observation of the miniscus disappearance in an optical cell. For the R-32/125 system, 35 saturation density data were measured at three compositions, 10, 35, and 50 mass % R-32. Nineteen saturation density data were also measured for R-125/143a (50/50 mass %). The critical temperatures and densities for these binary refrigerants were determined by taking into consideration the level and location of the meniscus disappearance as well as the intensity of the critical opalescence. Correlations to represent the critical loci of these binary refrigerants for an entire range of compositions have been developed. The experimental uncertainties of the saturation density data are estimated to be within 9 mK in temperature and 0.5 to 5.0 kg{center{underscore}dot}m{sup {minus}3} in density. The uncertainties of the critical temperature and density are estimated to be within 12 to 14 mK and 4 to 8 kg{center{underscore}dot}m{sup {minus}3}, respectively.

Slow recombination centers in cadmium selenide monocrystalline films

International Nuclear Information System (INIS)

Smyntyna, V.A.

1983-01-01

As a result of annealing when concentration of selenium Vacancies decreases due to their diffusion towards the surface, show recombination K-centers begin to influence the photoelectric properties of monocrystalline cadmium selenide layers. Energy levels of K-centers are located by 0.23-0.25 eV over the valent zone ceiling. The nature of K-centers is determined by the presence in the cadmium selenide layer structure of intrisic defects-cadmium vacancies in contrast to r-centers of slow recombination which are bound with impurities in a semiconductor material

FBR Plant Engineering Center annual report 2012

International Nuclear Information System (INIS)

2013-12-01

This annual report shows the last year's R and D activities of currently-reorganized FBR Plant Engineering Center, which was established on April 1, 2009. FBR Safety Technology Center was founded on April 1, 2013 by the consolidation of both the activities of 'former FBR Plant Engineering Center' and a portion of 'FBR Safety Evaluation Unit, Advanced Nuclear System Research and Development Directorate', especially concentrating on safety evaluations and analyses for severe accidents. As for FBR safety technology, it is necessary to continuously make an effort for compliance with new safety regulations in preparation for 'Monju' to restart, for safety enhancement evaluation and for safety technology upgrading. In this context, the new organization was founded in order to reinforce the safety evaluation capability, which will surely and steadily promote FBR safety-technology related activities. As a result, FBR Plant Engineering Center was abolished. This report summarizes the R and D activities at the former FBR Plant Engineering Center, aiming at contributing to the commercialization by using operation experiences and technology development results derived from the actual reactor 'Monju'. The activities are divided into five areas of operation-and-maintenance engineering, sodium engineering, reactor-core-and-fuel engineering, plant engineering, and safety engineering. This annual report is intended for a report of the activities of individual researcher in the center rather than that of the progress of the center as a whole. This will clarify the individual themes, progresses and problems of each researcher, which will, hopefully, facilitate communication with the outside researchers. (author)

Si-related color centers in nanocrystalline diamond thin films

Czech Academy of Sciences Publication Activity Database

Potocký, Štěpán; Holovský, Jakub; Remeš, Zdeněk; Müller, Martin; Kočka, Jan; Kromka, Alexander

2014-01-01

Roč. 251, č. 12 (2014), s. 2603-2606 ISSN 0370-1972 R&D Projects: GA TA ČR TA01011740; GA ČR(CZ) GA14-04790S; GA MŠk LH12186 Institutional support: RVO:68378271 Keywords : chemical vapor deposition * color center * diamond * photoluminescence * plasma Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 1.489, year: 2014

NASA's engineering research centers and interdisciplinary education

Science.gov (United States)

Johnston, Gordon I.

1990-01-01

A new program of interactive education between NASA and the academic community aims to improve research and education, provide long-term, stable funding, and support cross-disciplinary and multi-disciplinary research. The mission of NASA's Office of Aeronautics, Exploration and Technology (OAET) is discussed and it is pointed out that the OAET conducts about 10 percent of its total R&D program at U.S. universities. Other NASA university-based programs are listed including the Office of Commercial Programs Centers for the Commercial Development of Space (CCDS) and the National Space Grant program. The importance of university space engineering centers and the selection of the nine current centers are discussed. A detailed composite description is provided of the University Space Engineering Research Centers. Other specialized centers are described such as the Center for Space Construction, the Mars Mission Research Center, and the Center for Intelligent Robotic Systems for Space Exploration. Approaches to educational outreach are discussed.

The role of the right superior temporal gyrus in stimulus-centered spatial processing.

Science.gov (United States)

Shah-Basak, Priyanka P; Chen, Peii; Caulfield, Kevin; Medina, Jared; Hamilton, Roy H

2018-05-01

Although emerging neuropsychological evidence supports the involvement of temporal areas, and in particular the right superior temporal gyrus (STG), in allocentric neglect deficits, the role of STG in healthy spatial processing remains elusive. While several functional brain imaging studies have demonstrated involvement of the STG in tasks involving explicit stimulus-centered judgments, prior rTMS studies targeting the right STG did not find the expected neglect-like rightward bias in size judgments using the conventional landmark task. The objective of the current study was to investigate whether disruption of the right STG using inhibitory repetitive transcranial magnetic stimulation (rTMS) could impact stimulus-centered, allocentric spatial processing in healthy individuals. A lateralized version of the landmark task was developed to accentuate the dissociation between viewer-centered and stimulus-centered reference frames. We predicted that inhibiting activity in the right STG would decrease accuracy because of induced rightward bias centered on the line stimulus irrespective of its viewer-centered or egocentric locations. Eleven healthy, right-handed adults underwent the lateralized landmark task. After viewing each stimulus, participants had to judge whether the line was bisected, or whether the left (left-long trials) or the right segment (right-long trials) of the line was longer. Participants repeated the task before (pre-rTMS) and after (post-rTMS) receiving 20 min of 1 Hz rTMS over the right STG, the right supramarginal gyrus (SMG), and the vertex (a control site) during three separate visits. Linear mixed models for binomial data were generated with either accuracy or judgment errors as dependent variables, to compare 1) performance across trial types (bisection, non-bisection), and 2) pre- vs. post-rTMS performance between the vertex and the STG and the vertex and the SMG. Line eccentricity (z = 4.31, p right-long type by 10.7% on bisection

Silicon vacancy-related centers in non-irradiated 6H-SiC nanostructur

Czech Academy of Sciences Publication Activity Database

Bagraev, N.T.; Danilovskii, E.Yu.; Gets, D.S.; Kalabukhova, E.N.; Klyachkin, L.E.; Koudryavtsev, A.A.; Malyarenko, A.M.; Mashkov, V.A.; Savchenko, Dariia; Shanina, B.D.

2015-01-01

Roč. 49, č. 5 (2015), 649-657 ISSN 1063-7826 R&D Projects: GA ČR GP13-06697P; GA MŠk(CZ) LM2011029 Grant - others:SAFMAT(XE) CZ.2.16/3.1.00/22132 Institutional support: RVO:68378271 Keywords : electron spin resonance * 6H-SiC nanostructures * silicon vacancy related centers * NV centers Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.701, year: 2015

Overview of the NASA balloon R&D program

Science.gov (United States)

Smith, I. Steve, Jr.

1994-01-01

The catastrophic balloon failure during the first half of the 1980's identified the need for a comprehensive and continuing balloon research and development (R&D) commitment by NASA. Technical understanding was lacking in many of the disciplines and processes associated with scientific ballooning. A comprehensive balloon R&D plan was developed in 1986 and implemented in 1987. The objectives were to develop the understanding of balloon system performance, limitations, and failure mechanisms. The program consisted of five major technical areas: structures, performance and analysis, materials, chemistry and processing, and quality control. Research activitites have been conducted at NASA/Goddard Space Flight Center (GSFC)-Wallops Flight Facility (WFF), other NASA centers and government facilities, universities, and the balloon manufacturers. Several new and increased capabilities and resources have resulted from this activity. The findings, capabilities, and plan of the balloon R&D program are presented.

A multipurpose radiation service center

International Nuclear Information System (INIS)

Hofmann, E.-G.

1977-01-01

In Germany, AEG-Telefunken has been working as a supplier of irradiation equipment for more than ten years. There is a close cooperation with Radiation Dynamics Inc., Westbury, N.Y. Radiation sources are available for most industrial applications. As a special service AEG is establishing a multipurpose radiation service center in Hamburg-Wedel, Germany. This center will be used by a host of companies to investigate the effects of radiation on a broad range of materials, to develop special processing equipment, to process customer supplied products and to perform R and D work and contracts. Initially this service center will be equipped with one research type High-Power X-ray Unit (200 kV/32 mA) and one industrial type Dynamitron accelerator (1500 kV/37.5 kW). (author)

Breast Cancer Translational Research Center of Excellence

Science.gov (United States)

2015-09-01

CBCP) Breast Center is the Army-recognized and Military-recognized specialty referral center for t r i - se rv ice active duty personnel from around...development of customized treatment options in patients with HER2+ breast cancer. Objective 1 Evaluate differences in the molecular profiles of...2014CBCP & CCBB Analysis of Errors & Corrections 11/7/2014Customer Satisfaction Results Analysis 1/7/2015Audit of signed-out tissue samples in -80 freezer

Correlation of paramagnetic states and molecular structure in bacterial photosynthetic reaction centers: The symmetry of the primary electron donor in Rhodopseudomonas viridis and Rhodobacter sphaeroides R-26

International Nuclear Information System (INIS)

Norris, J.R.; Budil, D.E.; Gast, P.; Chang, C.H.; El-Kabbani, O.; Schiffer, M.

1989-01-01

The orientation of the principal axes of the primary electron donor triplet state measured in single crystals of photosynthetic reaction centers is compared to the x-ray structures of the bacteria Rhodobacter (Rb.) sphaeroides R-26 and Rhodopseudomonas (Rps.) viridis. The primary donor of Rps. viridis is significantly different from that of Rb. sphaeroides. The measured directions of the axes indicate that triplet excitation is almost completely localized on the L-subunit half of the dimer in Rps. viridis but is more symmetrically distributed on the dimeric donor in Rb. sphaeroides R-26. The large reduction of the zero field splitting parameters relative to monomeric bacteriochlorophyll triplet in vitro suggests significant participation of asymmetrical charge transfer electronic configurations in the special pair triplet state of both organisms

Sandia National Laboratories: Microsystems Science & Technology Center

Science.gov (United States)

Environmental Management System Pollution Prevention History 60 impacts Diversity Locations Facts & Figures Programs Nuclear Weapons About Nuclear Weapons Safety & Security Weapons Science & Technology Robotics R&D 100 Awards Laboratory Directed Research & Development Technology Deployment Centers

Rolling Deck to Repository (R2R): A "Linked Data" Approach for the U.S. Academic Research Fleet

Science.gov (United States)

Arko, R.; Chandler, C.; Clark, P.; Milan, A.; Mize, J.

2012-04-01

The Rolling Deck to Repository (R2R; http://rvdata.us/) program is developing infrastructure to routinely document, assess, and preserve the underway sensor data from U.S. academic research vessels. The R2R master catalog of vessels, instrument systems, operating institutions, cruises, personnel, data sets, event logs, and field reports has grown to over 2,200 cruises in less than two years, and is now accessible via Web services. This catalog is of great value to peer data systems, ranging from large inter/national data centers to small disciplinary data offices, as an aid in quality controlling their own collections and finding related data from authoritative sources. R2R breaks with the tradition of stovepipe portals built around complex search interfaces tightly bound to backend databases. Instead, we have adopted a Linked Data approach to publish our catalog content, based on the W3C Resource Description Framework (RDF) and Uniform Resource Identifiers (URIs). Our data model is published as a collection of W3C Simple Knowledge Organization System (SKOS) concepts, mapped to partner vocabularies such as those developed by the Global Change Master Directory (GCMD) and the pan-European SeaDataNet partnership, and our catalog content is published as collections of RDF resources with globally unique and persistent identifiers. The combination of exposing our data model, mapping local terms to community-wide vocabularies, and using reliable identifiers improves interoperability and reduces ambiguity. R2R's metric of success is the degree to which peer data systems harvest and reuse our content. R2R is working collaboratively with the NOAA National Data Centers and the NSF-funded Biological and Chemical Oceanography Data Management Office (BCO-DMO) on a range of Linked Data pilot applications, including production of ISO-compliant metadata and deployment of a RDF Query Language (SPARQL) interface. Our objective is to support a distributed, loosely federated network of

Functional interactions within 23S rRNA involving the peptidyltransferase center

DEFF Research Database (Denmark)

Douthwaite, S

1992-01-01

resistance than either mutation alone. 23S rRNAs containing mutations at position 2058 that confer clindamycin and erythromycin resistance become deleterious to cell growth when combined with the 2032A mutation and, additionally, confer hypersensitivity to erythromycin and sensitivity to clindamycin...

ICA-based artifact removal diminishes scan site differences in multi-center resting-state fMRI.

Directory of Open Access Journals (Sweden)

Rogier Alexander Feis

2015-10-01

Full Text Available Resting-state fMRI (R-fMRI has shown considerable promise in providing potential biomarkers for diagnosis, prognosis and drug response across a range of diseases. Incorporating R-fMRI into multi-center studies is becoming increasingly popular, imposing technical challenges on data acquisition and analysis, as fMRI data is particularly sensitive to structured noise resulting from hardware, software and environmental differences. Here, we investigated whether a novel clean up tool for structured noise was capable of reducing center-related R-fMRI differences between healthy subjects.We analyzed 3 Tesla R-fMRI data from 72 subjects, half of whom were scanned with eyes closed in a Philips Achieva system in The Netherlands, and half of whom were scanned with eyes open in a Siemens Trio system in the UK. After pre-statistical processing and individual Independent Component Analysis (ICA, FMRIB’s ICA-based X-noiseifier (FIX was used to remove noise components from the data. GICA and dual regression were run and non-parametric statistics were used to compare spatial maps between groups before and after applying FIX.Large significant differences were found in all resting-state networks between study sites before using FIX, most of which were reduced to non-significant after applying FIX. The between-center difference in the medial/primary visual network, presumably reflecting a between-center difference in protocol, remained statistically different.FIX helps facilitate multi-center R-fMRI research by diminishing structured noise from R-fMRI data. In doing so, it improves combination of existing data from different centers in new settings and comparison of rare diseases and risk genes for which adequate sample size remains a challenge.

Energy management of internet data centers in smart grid

CERN Document Server

Jiang, Tao; Cao, Yang

2015-01-01

This book reports the latest findings on intelligent energy management of Internet data centers in smart-grid environments. The book gathers novel research ideas in Internet data center energy management, especially scenarios with cyber-related vulnerabilities, power outages and carbon emission constraints. The book will be of interest to university researchers, R&D engineers and graduate students in communication and networking areas who wish to learn the core principles, methods, algorithms, and applications of energy management of Internet data centers in smart grids.

Proposal of an Observatory of Trends for Nanotechnology in the Context of Technology Management in an Oil and Gas R&D Center – Case: Nanotechnology

Directory of Open Access Journals (Sweden)

Viviane Masseran Antunes Parreiras

2013-12-01

Full Text Available The paper presents basic concepts on nanotechnology and the use of this in an oil and gas research and development (R&D center, the Research and Development Center Leopoldo Américo Miguez de Mello of Petrobras (CENPES. The aim of this paper is to present a proposal of an observatory of trends in the area of nanotechnology at CENPES, to generate information, such as the state of the art technologies, technological trajectories, movements of competitors and partners, and aspects relating to regulations and incentives for decision making in the technology management process. The model consists of five steps that should occur in a continuous cycle: literature review, expert consultation, analysis of opportunities and threats, timelines or roadmaps, and monitoring. In conclusion, the proposed observatory includes a set of topics (variables, sources, techniques of competitive technical intelligence and technological foresight, systematized in order to support decision making in technology management.

Structural and Infrastructural Underpinnings of International R&D Networks

DEFF Research Database (Denmark)

Niang, Mohamed; Sørensen, Brian Vejrum

2009-01-01

This paper explores the process of globally distributing R&D activities with an emphasis on the effects of network maturity. It discusses emerging configurations by asking how the structure and infrastructure of international R&D networks evolve along with the move from a strong R&D center...... to dispersed development. Drawing from case studies of two international R&D networks, it presents a capability maturity model and argues that understanding the interaction between new structures and infrastructures of the dispersed networks has become a key requirement for developing organizational...

Improvement of the center boring device for the irradiated fuel pellets

Energy Technology Data Exchange (ETDEWEB)

Usami, Koji; Onozawa, Atsushi; Kimura, Yasuhiko; Sakuraba, Naotoshi; Shiina, Hidenori; Harada, Akito; Nakata, Masahito [Japan Atomic Energy Agency, Nuclear Science Research Inst., Tokai, Ibaraki (Japan)

2012-03-15

The power ramp tests performed at JMTR in Oarai R and D Center are objected to study the safety margin of the high burnup fuels. One of the important parameters measured during this test is the center temperature of the fuel pellet. For this measurement, a thermocouple is installed into the hole bored at the pellet center by the center boring device, which can fix the fuel pellet with the frozen CO{sub 2} gas during its boring process. At the Reactor Fuel Examination Facility (RFEF) in Tokai R and D Center, several improvements were applied for the previous boring device to gain its performance and reliability. The major improvements are the change of the drill bit, modification of the boring process and the optimization of the remote operability. The mock-up test will be performed with the irradiated fuel pellet to confirm the benefit of improvement. This study was conducted under a contract with the Nuclear and Industrial Safety Agency (NISA) of the Ministry of Economy, Trade and Industry (METI). (author)

Site Investigation for Detection of KIJANG Reactor Core Center

Energy Technology Data Exchange (ETDEWEB)

Kwon, Tae-Hyun; Kim, Jun Yeon; Kim, Jeeyoung [KAERI, Daejeon (Korea, Republic of)

2015-05-15

It was planned for the end of March 2017 and extended to April 2018 according to the government budget adjustment. The KJRR project is intended for filling the self-sufficiency of RI demand including Mo-99, increasing the NTD capacity and developing technologies related to the research reactor. In project, site investigation is the first activity that defines seismologic and related geologic aspects of the site. Site investigation was carried out from Oct. 2012 to Jan. 2014 and this study is intended to describe detail procedures in locating the reactor core center. The location of the reactor core center was determined by collectively reviewing not only geological information but also information from architects engineering. EL 50m was selected as ground level by levering construction cost. Four recommended locations (R-1a - R-1d) are displayed for the reactor core center. R-1a was found optimal in consideration of medium rock contour, portion of medium rock covering reactor buildings, construction cost, physical protection and electrical resistivity. It is noted that engineering properties of the medium rock is TCR/RQD 100/53, elastic modulus 7,710 - 8,720MPa, permeability coefficient 2.92E-06cm/s, and S-wave velocity 1,380m/s, sound for foundations of reactor buildings.

Factors That Attract Foreign Pharmaceutical Companies Setting Up R&D Center In Malaysia

OpenAIRE

Hee, Kenneth Kang Koon

2003-01-01

The development of the biotechnology and pharmaceutical industry is far reaching and their broad applications and great impacts have attracted global interest to enter these industries. Pharmaceutical R&D is a costly and risky business, but in recent years the financial rewards from R&D have more than offset its cost and risk. In order to ensure the continuous growth of Malaysia’s economy, the Malaysia government is actively developing these industries to be their star industry in 21st centur...

CONSUMIDOR ADOLESCENTE EM AMBIENTE DE SHOPPING CENTER

Directory of Open Access Journals (Sweden)

Lunie Imamura Lima

2009-07-01

shopping center da cidade de Fortaleza (CE e objetivou conhecer as características bio-demográficas, os hábitos de utilização do shopping e os principais elementos influenciadores do processo de decisão de compra deste segmento. De natureza descritiva, quantitativa, com corte transversal; a pesquisa utilizou um questionário estruturado aplicado a uma amostra não-probabilística por conveniência, com maioria do sexo masculino, faixa etária entre 13 e 15 anos, provenientes de famílias de classe alta e renda familiar mensal superior a R$ 2700,00. Os resultados demonstraram que a maioria dos respondentes recebe mesada no valor menor que R$ 80,00; vai ao shopping de carro com pais ou parentes; gasta de R$ 10,00 a R$ 30,00; freqüenta o local 3 vezes na semana; permanece de 4 a 6 horas e é acompanhado pelos amigos. Ainda mostrou que pais ou familiares são os principais elementos influenciadores do processo de decisão de compra, enquanto os amigos os principais meios de informações sobre novos produtos. O estudo pretende contribuir com a literatura científica nas áreas de Marketing e Comportamento do consumidor e servir de instrumento gerencial aos dirigentes de shopping centers.

R-ES-ONANCE--INo-ve-mber

Indian Academy of Sciences (India)

Physiology or Medicine: has been jointly awarded to. Leland H Hartwell, Fred Hutchinson Cancer Research Center, University of Seattle, USA. R Timothy (Tim) Hunt, Clare Hall Laboratories, Cell Cycle Control Laboratory, UK. Paul M Nurse, Lincoln's Inn Fields Laboratories, Cell Cycle Laboratory, UK for their discoveries of ...

Edirne merkez ilçede prematür ölümler, 2004 ve 2008/Premature mortality in provincial center of Edirne, 2004 and 2008

Directory of Open Access Journals (Sweden)

Muzaffer Eskiocak

2014-04-01

Full Text Available ÖzetAmaç: Bu çalışmada; Edirne Merkez ilçe ve bağlı köylerde 2004 ve 2008 yıllarında olan prematür ölüm nedenlerini ve bu ölümlere bağlı oluşan potansiyel yaşam yılı kayıplarını belirlemek amaçlanmıştır. Yöntem: Çalışma kesitsel bir araştırmadır. Edirne Merkez ilçe ve bağlı köylerde 2004 ve 2008 yılında meydana gelen ölümler mezarlık, hastane, belediye ve adli tabiplik kayıtlarından derlenmiştir. Ölümler zaman, yer, cinsiyet ve nedenlerine yönelik olarak incelenmiştir. Prematür ölümlere bağlı oluşan Potansiyel Yaşam Yılı Kayıpları (PYYK, Years Potential Life Lost hesaplanmıştır. Bulgular: Edirne Merkez ilçede kaba ölüm hızı 2004 ve 2008 yıllarında sırasıyla binde 5.17 ve binde 5.48 olarak bulunmuştur. 65 yaş altında gerçekleşen ölümler prematür ölüm olarak değerlendirilmiştir. Prematür ölüm oranları 2004 yılında %34.9, 2008 yılında %35.5 olarak tespit edilmiştir. Prematür ölümlerin 2004 yılında %69.9’u, 2008 yılında %65.8’i erkek ölümleridir ve 2004 yılında %14.3’ü, 2008 yılında %8.1’i kırsalda gerçekleşmiştir. Prematür ölümlere bağlı PYYK 2004 yılında 4809 yıl, 2008 yılında 4929 yıldır. Her iki yılda prematür ölüme neden olan ilk beş ölüm nedeni; dolaşım sistemi hastalıkları, kanserler, iyi tanımlayan durumlar, kazalar, solunum sistemi hastalıklarıdır. Sonuç: Edirne Merkez ilçede prematür ölümler tüm ölümlerin yaklaşık üçte birini oluşturmaktadır ve en sık görülen prematür ölüm nedenleri dolaşım sistemi hastalıkları ve kanserlerdir.Anahtar Kelimeler: Prematür mortalite, potansiyel yaşam yılı kaybıAbstractObjective: This study determined the causes of premature mortalities, the potential years of life lost (PYLL and the economic losses due to premature mortality in the provincial centre of Edirne. Methods:This is a cross-sectional study. Mortality data in Edirne for the

A typical R and D center on radiation processing in China

International Nuclear Information System (INIS)

Sun Jlazhen

1995-01-01

The industrial application of radiation processing has been growing rapidly in China since 1980s in such fields as producing radiation-crosslinked heat shrinkable materials and radiation-crosslinked wires and cables, sterilization of medical products and so on. Changchun Institute of Applied Chemistry (CIAC) as one of the earliest organizations in which the fundamental research works on polymer radiation chemistry have been carried out has played a major role for the R and D of the radiation processing of polymers. From the R and D activities at CIAC, it can be seen how a Chinese research institute transfers its results of fundamental research works into large scale production. The improvement of the weakness of fluoropolymers by radiation crosslinking, the modification of the Charlesby-Pinner equation that describes the relationship of sol fraction to irradiation dose, the radiation grafting for preparing functional materials, the radiation crosslinking of polymer blends and the effect of antioxidant on the radiation crosslinking of polymers are reported. Also applied research works and the radiation processing at CIAC are described. (K.I.)

A Decade of Friction Stir Welding R and D at NASA's Marshall Space Flight Center and a Glance into the Future

Science.gov (United States)

Ding, Jeff; Carter, Bob; Lawless, Kirby; Nunes, Arthur; Russell, Carolyn; Suites, Michael; Schneider, Judy

2006-01-01

Welding at NASA's Marshall Space Flight Center (MSFC), Huntsville, Alabama, has taken a new direction through the last 10 years. Fusion welding processes, namely variable polarity plasma arc (VPPA) and tungsten inert gas (TIG) were once the corner stone of welding development in the Space Flight Center's welding laboratories, located in the part of MSFC know as National Center for Advanced Manufacturing (NCM). Developed specifically to support the Shuttle Program's External Tank and later International Space Station manufacturing programs, was viewed as the paragon of welding processes for joining aluminum alloys. Much has changed since 1994, however, when NASA's Jeff Ding brought the FSW process to the NASA agency. Although, at that time, FSW was little more than a "lab curiosity", NASA researchers started investigating where the FSW process would best fit NASA manufacturing programs. A laboratory FSW system was procured and the first welds were made in fall of 1995. The small initial investment NASA made into the first FSW system has certainly paid off for the NASA agency in terms of cost savings, hardware quality and notoriety. FSW is now a part of Shuttle External Tank (ET) production and the preferred weld process for the manufacturing of components for the new Crew Launch Vehicle (CLV) and Heavy Lift Launch Vehicle (HLLV) that will take this country back to the moon. It is one of the solid state welding processes being considered for on-orbit space welding and repair, and is of considerable interest for Department of Defense @OD) manufacturing programs. MSFC involvement in these and other programs makes NASA a driving force in this country's development of FSW and other solid state welding technologies. Now, a decade later, almost the entire on-going welding R&D at MSFC now focuses on FSW and other more advanced solid state welding processes.

Rolling Deck to Repository (R2R): A "Linked Data" Approach for the U.S. Academic Research Fleet

Science.gov (United States)

Arko, R. A.; Chandler, C. L.; Clark, P. D.; Milan, A.; Mize, J.

2011-12-01

The U.S. academic research fleet is an essential mobile observing platform for ocean science. The NSF-funded Rolling Deck to Repository (R2R) program is working with the fleet community to routinely document, assess, and preserve data from the underway sensor systems on each vessel. The R2R facility maintains a master catalog of vessels, instrument systems, operating institutions, cruises, personnel, and data sets. In less than two years, the catalog has grown to over 2,000 cruises including unique identifiers for vessel deployments, project titles, chief scientists, dates, ports, survey targets, and navigation tracks. This master catalog is of great value to peer data systems, ranging from large national data centers to small disciplinary data offices, as an aid in organizing, extending, and quality controlling their own collections and finding related data from authoritative sources. R2R breaks with the tradition of stovepipe portals built around complex search interfaces tightly bound to backend databases. Instead, we have adopted a Linked Data approach to publish our catalog content, based on the W3C Resource Description Framework (RDF) and Uniform Resource Identifiers (URIs). Our data model is published as a collection of W3C Simple Knowledge Organization System (SKOS) concepts, mapped to partner vocabularies such as those developed by the Global Change Master Directory (GCMD) and the pan-European SeaDataNet partnership, and our catalog content is published as collections of RDF resources with globally unique and persistent identifiers. The combination of exposing our data model, mapping local terms to community-wide vocabularies, and using reliable identifiers improves interoperability and reduces ambiguity. R2R's metric of success is the degree to which peer data systems routinely harvest and reuse our content. R2R is working collaboratively with the NOAA National Data Centers and the NSF-funded Biological and Chemical Oceanography Data Management Office

Spatial Distribution of Market Centers

Directory of Open Access Journals (Sweden)

Md. Morshedul Islam

2018-03-01

Full Text Available The present study is an attempt to find the location pattern, distribution and their sphere of influences of market centers in Rangpur City Corporation, Bangladesh. Rangpur is facing some problems like a traffic jam, noisy environment, population pressure etc due to the over population in full day long in the center of this city, all of the whole sale and retail sale markets are located in the middle. Location of Market is always influencing the daily life of the city population who are directly or indirectly connected with the market. If the market strategically distributed in an area they don’t face such kind of problems. Analysis or investigation shows that at about all of the market centers are located in the center of Rangpur and in the residential area of Rangpur. The maximum 67% market centers are found in the high-income residential area. Rangpur City Corporation, Bangladesh Bureau of Statistics and survey of Bangladesh provided the maps, reports and relevant documents of the study. The spatial dispersion pattern of market centers is clustered together at one place 0.33(Nearest Neighbor Index value, R found in the study area. Geographical Information System (GIS and other software also used to analyze the maps and diagrams. Investigation refers that, the market of Rangpur city have a clustered pattern and different levels of market centers found on the bases of centrality scores. By this centrality scores or levels, found the variation of influencing spheres of market centers in Rangpur City.

Wyoming DOE EPSCoR

Energy Technology Data Exchange (ETDEWEB)

Gern, W.A.

2004-01-15

All of the research and human resource development projects were systemic in nature with real potential for becoming self sustaining. They concentrated on building permanent structure, such as faculty expertise, research equipment, the SEM Minority Center, and the School of Environment and Natural Resources. It was the intent of the DOE/EPSCoR project to permanently change the way Wyoming does business in energy-related research, human development for science and engineering careers, and in relationships between Wyoming industry, State Government and UW. While there is still much to be done, the DOE/EPSCoR implementation award has been successful in accomplishing that change and enhancing UW's competitiveness associated with coal utilization, electrical energy efficiency, and environmental remediation.

Når det er svært at være ung i DK

DEFF Research Database (Denmark)

Nielsen, Jens Christian; Sørensen, Niels Ulrik; Ozmec, Martha Nina

I rapporten Når det er svært at være ung i DK – unges trivsel og mistrivsel i tal offentliggør Center for Ungdomsforskning resultaterne af en stor videnskabelig spørgeskemaundersøgelse om trivsel og mistrivsel blandt 15-24-årige unge i Danmark. Rapporten indgår i det treårige forskningsprojekt Når...... det er svært at være ung i DK, som Center for Ungdomsforskning udfører med støtte fra Egmont Fonden. Rapporten bygger på telefoninterviews med 3.481 unge, der udgør et repræsentativt udsnit af alle 15-24-årige unge i Danmark. I rapporten forfølges de unges trivsel og mistrivsel gennem to spor: 1) Et...

Naval Health Research Center 1985 Annual Report

Science.gov (United States)

1985-01-01

strengthening programs for the entire crew. Aerobic programs for select populations (e.g., overweight personnel), however, were found on 20% of the...Institute, Lima Detachment, Peru (Command) 25-26 UCOR R. Kallal, CUP W. J. Lambert, & M. Nave, Naval Data Services Center, Bethesda, Maryland (Dr

Existence of relativistic stars in f(R) gravity

International Nuclear Information System (INIS)

Upadhye, Amol; Hu, Wayne

2009-01-01

We refute recent claims in the literature that stars with relativistically deep potentials cannot exist in f(R) gravity. Numerical examples of stable stars, including relativistic (GM * /r * ∼0.1), constant density stars, are studied. As a star is made larger, nonlinear 'chameleon' effects screen much of the star's mass, stabilizing gravity at the stellar center. Furthermore, we show that the onset of this chameleon screening is unrelated to strong gravity. At large central pressures P>ρ/3, f(R) gravity, like general relativity, does have a maximum gravitational potential, but at a slightly smaller value: GM * /r * | max =0.345<4/9 for constant density and one choice of parameters. This difference is associated with negative central curvature R under general relativity not being accessed in the f(R) model, but does not apply to any known astrophysical object.

How to Create "Thriller" PowerPoints[R] in the Classroom!

Science.gov (United States)

Berk, Ronald A.

2012-01-01

PowerPoint[R] presentations in academia have a reputation for being less than engaging in this era of learner-centered teaching. The Net Generation also presents a formidable challenge to using PowerPoint[R]. Although the research on the basic elements is rather sparse, the multimedia elements of movement, music, and videos have a stronger…

Erectile Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Outcomes from a Multi-Center Study and Risk Factor Analysis in a Single Center.

Directory of Open Access Journals (Sweden)

Yadong Zhang

Full Text Available The aim of this study was to investigate the prevalence of erectile dysfunction (ED in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS and explore the influence of UPOINT domains, National Institutes of Health-CP symptom index (NIH-CPSI and other factors on ED prevalence. This was a prospective study of consecutive patients with CP/CPPS seen at 11 tertiary hospitals during January-July 2014. ED was diagnosed as a score of<21 on the International Index of Erectile Function (IIEF-5. Patients from one center were evaluated by the UPOINT system and NIH-CPSI. Each patient was assessed using clinical examination, asocio-demographic questionnaire, the Patient Health Questionnaire (PHQ, the Pain Catastrophizing Scale (PCS, NIH-CPSI and IIEF-5.1406 patients from 11 centers (mean age, 32.18 years; range 18-60 years were enrolled. ED was found in 638/1406 patients (45.4%, and was categorized as mild in 291(45.6%, moderate in 297(46.6% and severe in50(7.7%. 192 patients from one center(mean age,31.3 years; range 18-57 years were further studied.IIEF-5 score correlated negatively with NIH-CPSI(r = 0.251, PHQ (r = 0.355 and PCS (r = 0.322scores (P<0.001.PHQ score correlated positively with NIH-CPSI (r = 0.586 and PCS(r = 0.662 scores (P<0.001.NIH-CPSI, PHQ, PCS and IIEF-5 scores did not differ significantly between class IIIA and IIIB CP/CPPS. Multivariate logistic regression showed that UPOINT psychological (P domain and NIH-CPSI symptom severity were independent risk factors for ED in CP/CPPS. It is concluded that psychological factors and symptom severity are independent risk factors for ED in CP/CPPS.

Learning System Center App Controller

CERN Document Server

Naeem, Nasir

2015-01-01

This book is intended for IT professionals working with Hyper-V, Azure cloud, VMM, and private cloud technologies who are looking for a quick way to get up and running with System Center 2012 R2 App Controller. To get the most out of this book, you should be familiar with Microsoft Hyper-V technology. Knowledge of Virtual Machine Manager is helpful but not mandatory.

Research and technology, 1991. Langley Research Center

Science.gov (United States)

1992-01-01

The mission of the NASA Langley Research Center is to increase the knowledge and capability of the United States in a full range of aeronautics disciplines and in selected space disciplines. This mission will be accomplished by performing innovative research relevant to national needs and Agency goals, transferring technology to users in a timely manner, and providing development support to other United States Government agencies, industry, and other NASA centers. Highlights are given of the major accomplishments and applications that have been made during the past year. The highlights illustrate both the broad range of the research and technology (R&T) activities at NASA Langley Research Center and the contributions of this work toward maintaining United States leadership in aeronautics and space research.

(1R,2R-N,N′-Bis(ferrocenylmethyl-1,2-diphenylethane-1,2-diamine

Directory of Open Access Journals (Sweden)

Yi Guo

2010-08-01

Full Text Available The title compound, [Fe2(C5H52(C26H26N2], was synthesized from a chiral diamine and ferrocenecarboxaldehyde and subsequent reduction with NaBH4. It has two chiral centers which both exhibit an R configuration. Two ferrocene groups are present in the molecular structure, with their cyclopentadienyl ring planes showing an almost perpendicular arrangement [dihedral angle 88.6 (1°].

NASA Johnson Space Center SBIR STTR Program Technology Innovations

Science.gov (United States)

Krishen, Kumar

2007-01-01

The Small Business Innovation Research (SBIR) Program increases opportunities for small businesses to participate in research and development (R&D), increases employment, and improves U.S. competitiveness. Specifically the program stimulates U.S. technological innovation by using small businesses to meet federal R&D needs, increasing private-sector commercialization of innovations derived from federal R&D, and fostering and encouraging the participation of socially disadvantaged businesses. In 2000, the Small Business Technology Transfer (STTR) Program extended and strengthened the SBIR Program, increasing its emphasis on pursuing commercial applications by awarding contracts to small business concerns for cooperative R&D with a nonprofit research institution. Modeled after the SBIR Program, STTR is nevertheless a separately funded activity. Technologies that have resulted from the Johnson Space Center SBIR STTR Program include: a device for regenerating iodinated resin beds; laser-assisted in-situ keratomileusis or LASIK; a miniature physiological monitoring device capable of collecting and analyzing a multitude of real-time signals to transmit medical data from remote locations to medical centers for diagnosis and intervention; a new thermal management system for fibers and fabrics giving rise to new line of garments and thermal-enhancing environments; and a highly electropositive material that attracts and retains electronegative particles in water.

Great aspirations: the postwar American college counseling center.

Science.gov (United States)

McCarthy, Tom

2014-02-01

In the decade after World War II, psychologists, eager to bring the benefits of counseling to larger numbers, convinced hundreds of American colleges and universities to establish counseling centers. Inspired by the educational-vocational counseling center founded by psychologists at the University of Minnesota in 1932, Carl R. Rogers's "client-centered" methods of personal adjustment counseling, and the 400-plus college counseling centers created by the Veterans Administration to provide the educational-vocational counseling benefit promised to returning World War II servicemen under the 1944 GI Bill, these counseling psychologists created a new place to practice where important currents in psychology, higher education, and federal policy converged and where they attempted to integrate educational-vocational counseling with personal adjustment counseling based on techniques from psychotherapy. By the mid-1960s, half of America's colleges and universities had established counseling centers, and more than 90% offered students educational, vocational, and psychological counseling services, a great achievement of the first generation of counseling psychologists.

On Symmetries of Extremal Black Holes with One and Two Centers

CERN Document Server

Ferrara, Sergio

2013-01-01

After a brief introduction to the Attractor Mechanism, we review the appearance of groups of type E7 as generalized electric-magnetic duality symmetries in locally supersymmetric theories of gravity, with particular emphasis on the symplectic structure of fluxes in the background of extremal black hole solutions, with one or two centers. In the latter case, the role of an "horizontal" symmetry SL(2,R) is elucidated by presenting a set of two-centered relations governing the structure of two-centered invariant polynomials.

Karlsruhe Nuclear Research Center. Progress report on research and development work in 1987

International Nuclear Information System (INIS)

1988-01-01

This summary of R and D work is the scientific annual report to be prepared by the research center in compliance with its statutes. The material is arranged by items of main activities, as given in the overall R and D programme set up for the research center. The various reports prepared by the individual institutes and principal departments are presented under their relevant subject headings. The annual report is intended to demonstrate the progress achieved in the tasks and activities assigned by the R and D programme of the research center, by referring to the purposes and goals stated in the programme, showing the joint or separate efforts and achievements of the institutes. Details and results of activities are found in the scientific-technical publications given in the bibliographical survey, and in the internal primary surveys. The main activities of the research center include the following: Fast Breeder Project (PSB), Nuclear Fusion Project (PKF), Separation Nozzle Project (TDV), and Reprocessing and Waste Treatment Project (PWA), Ultimate Disposal of Radioactive Waste (ELA), Environment and Safety (U and S), Solids and Materials (FM), Nuclear and Particle Physics (KTP), Microtechniques (MT), Materials Handling (HT), Other Research Activities (SF). Organisational aspects and institutes and the list of publications conclude the report. (orig./HK) [de

National Space Science Data Center and World Data Center A for Rockets and Satellites - Ionospheric data holdings and services

Science.gov (United States)

Bilitza, D.; King, J. H.

1988-01-01

The activities and services of the National Space Science data Center (NSSDC) and the World Data Center A for Rockets and Satellites (WDC-A-R and S) are described with special emphasis on ionospheric physics. The present catalog/archive system is explained and future developments are indicated. In addition to the basic data acquisition, archiving, and dissemination functions, ongoing activities include the Central Online Data Directory (CODD), the Coordinated Data Analysis Workshopps (CDAW), the Space Physics Analysis Network (SPAN), advanced data management systems (CD/DIS, NCDS, PLDS), and publication of the NSSDC News, the SPACEWARN Bulletin, and several NSSD reports.

Planning and Management of Technology Deployment Center

International Nuclear Information System (INIS)

Park, Jae Won; Joo, Po Kook; Kim, Jun Yeon and others

2005-08-01

The R and D contents are summarized as follows ; Models were set-up for transferring the developed technologies to the industry and managing technology deployment center to vitalize the commercialization and then the set-up model was tried to apply for transferring technologies for commercialization and to define interfaces between the R and D and industrial applications In this project, new products and processes were developed for promoting the commercialization. Infra-structures were firmly set-up for the venture company promotion and technology deployment developed during executing the proton Engineering frontier Project. Commercialization methodology connection with industrial companies were studied by outside specializing institute. Development of gem-stone coloring and new photo catalyst producing techniques are very high value-adding technologies, therefore, experimental and theoretical R and D were transacted simultaneously to obtain the originality of the technology. The theoretical R and D was committed to a specialist outside

Randomized Phase II Study of R-CHOP With or Without Bortezomib in Previously Untreated Patients With Non-Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma.

Science.gov (United States)

Leonard, John P; Kolibaba, Kathryn S; Reeves, James A; Tulpule, Anil; Flinn, Ian W; Kolevska, Tatjana; Robles, Robert; Flowers, Christopher R; Collins, Robert; DiBella, Nicholas J; Papish, Steven W; Venugopal, Parameswaran; Horodner, Andrew; Tabatabai, Amir; Hajdenberg, Julio; Park, Jaehong; Neuwirth, Rachel; Mulligan, George; Suryanarayan, Kaveri; Esseltine, Dixie-Lee; de Vos, Sven

2017-11-01

Purpose To evaluate the impact of the addition of bortezomib to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) on outcomes in previously untreated patients with non-germinal center B-cell-like (non-GCB) diffuse large B-cell lymphoma (DLBCL). Patients and Methods After real-time determination of non-GCB DLBCL using the Hans immunohistochemistry algorithm, 206 patients were randomly assigned (1:1; stratified by International Prognostic Index [IPI] score) to six 21-day cycles of standard R-CHOP alone or R-CHOP plus bortezomib 1.3 mg/m 2 intravenously on days 1 and 4 (VR-CHOP). The primary end point, progression-free survival (PFS), was evaluated in 183 patients with centrally confirmed non-GCB DLBCL who received one or more doses of study drug (91 R-CHOP, 92 VR-CHOP). Results After a median follow-up of 34 months, with 25% (R-CHOP) and 18% (VR-CHOP) of patients having had PFS events, the hazard ratio (HR) for PFS was 0.73 (90% CI, 0.43 to 1.24) with VR-CHOP ( P = .611). Two-year PFS rates were 77.6% with R-CHOP and 82.0% with VR-CHOP; they were 65.1% versus 72.4% in patients with high-intermediate/high IPI (HR, 0.67; 90% CI, 0.34 to 1.29), and 90.0% versus 88.9% (HR, 0.85; 90% CI, 0.35 to 2.10) in patients with low/low-intermediate IPI. Overall response rate with R-CHOP and VR-CHOP was 98% and 96%, respectively. The overall survival HR was 0.75 (90% CI, 0.38 to 1.45); 2-year survival rates were 88.4% and 93.0%, respectively. In the safety population (100 R-CHOP and 101 VR-CHOP patients), grade ≥ 3 adverse events included neutropenia (53% v 49%), thrombocytopenia (13% v 29%), anemia (7% v 15%), leukopenia (26% v 25%), and neuropathy (1% v 5%). Conclusion Outcomes for newly diagnosed, prospectively enrolled patients with non-GCB DLBCL were more favorable than expected with R-CHOP and were not significantly improved by adding bortezomib.

Influence of gas chemistry on Si-V color centers in diamond films

Czech Academy of Sciences Publication Activity Database

Potocký, Štěpán; Ižák, Tibor; Varga, Marián; Kromka, Alexander

2015-01-01

Roč. 252, č. 11 (2015), s. 2580-2584 ISSN 0370-1972 R&D Projects: GA ČR(CZ) GA14-04790S Institutional support: RVO:68378271 Keywords : chemical vapor deposition * diamond * photoluminescence * plasma * silicon optical centers Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.522, year: 2015

Phthalate and PAH concentrations in dust collected from Danish homes and daycare centers

DEFF Research Database (Denmark)

Langer, Sarka; Weschler, Charles J.; Fischer, Andreas

2010-01-01

(diethyl phthalate (DEP), di(n-butyl) phthalate (DnBP), di(isobutyl) phthalate (DiBP), butyl benzyl phthalate (BBzP), di(2-ethylhexyl) phthalate (DEHP)) and three PAHs (pyrene, benz[a]anthracene (B[a]A) and benzo[a]pyrene (B[a]P)). The three PAHs and DEHP were detected in dust samples from all sites, while...... DEP. DnBP, DiBP and BBzP were detected in more than 75% of the bedrooms and more than 90% of the daycare centers. The dust mass-fractions of both phthalates and PAHs were log-normally distributed. With the exception of DEP, the mass-fractions of phthalates in dust were higher in daycare centers than...... homes: PAH mass-fractions in dust were similar in the two locations. There was no correlation among the different phthalates in either homes or daycare centers. In contrast, the PAH were correlated with one another more strongly so in homes (R-2 = 0.80-0.90) than in daycare centers (R-2 = 0...

Marine Corps Center for Lessons Learned. Volume 8, Issue 11, November 2012

Science.gov (United States)

2012-11-01

MARINE CORPS CENTER FOR LESSONS LEARNED M C C L L R E P O R T: F E AT U R E D A R T I C L E S A N D L E S S O N S : R E G U L A R F E AT U R E S...L O A D S F R O M T H E M C C L L W E B S I T E , OCTOBER 2012 R E G U L A R F E AT U R E S : Photo credit: Sgt Rachael Moore A Joint Terminal...Follower by Ira Chaleff, and ▪ Fahim Speaks by Fahim Fazli and Michael Moffett . 19 MCCLL Products "in the Pipeline" Several recent, ongoing and

An R&D Management Framework for Eco-Technology

Directory of Open Access Journals (Sweden)

Kenji Sano

2011-08-01

Full Text Available Although research and development (R&D affects new value-added creation, including that related to environmental aspects, there is little literature dealing with the integration of R&D management and eco-value. Here, eco-value of technology is defined as the advantage of environmental competitiveness in the market. This paper proposes a framework of R&D management of eco-technology (RDMOET, consisting of: (1 future research for sustainability; (2 making an original eco-theme portfolio and roadmap; (3 gap analysis and implementation of new eco-themes; and (4 eco-value evaluation. (1 and (4 are new processes compared with conventional R&D management. Through practice at the Corporate R&D Center of Toshiba Corporation, the usefulness of the proposed framework is verified from the viewpoint of not only technological eco-innovation, but also that of organizational learning for environmental sustainability.

Terrorirünnak filmis "World Trade Center" / Andris Feldmanis

Index Scriptorium Estoniae

Feldmanis, Andris, 1982-

2006-01-01

9. augustil esilinastus katastroofifilm "World Trade Center" : stsenarist Andrea Berloff : režissöör Oliver Stone : kunstnik Jan Roelfs : osades Nicholas Cage, Michael Pena, Stephen Dorff jpt : Ameerika Ühendriigid 2006. Ka filmi prototüüpidest

Pilot retrofit test of refrigerant R-134a for GDSCC

Science.gov (United States)

Albus, J.; Brown, B.; Dungao, M.; Spencer, G.

1994-01-01

NASA has issued an interim policy requiring all of its Centers to eliminate consumption (purchase) of stratospheric ozone-depleting substances, including chlorofluorocarbons (CFC's), by 1995. Also, plans must be outlined for the eventual phase out of their usage. The greatest source of CFC consumption and usage at the Goldstone Deep Space Communications Complex is refrigerant R-12, which is used in many of the facility's air-conditioning systems. A pilot retrofit test shows that retrofitting R-12 air-conditioning systems with hydrofluorocarbon R-13a would be a workable means to comply with the R-12 portion of NASA's policy. Results indicate acceptable cost levels and nearly equivalent system performance.

Center-of-mass correction and confinement radii of the composite vector bosons

International Nuclear Information System (INIS)

Tadic, D.; Tadic, G.

1985-01-01

Describing a composite W boson by a center-of-mass--corrected bag model one finds a relation R/sub W/ 3 M/sub W/ 3 / f/sub W/ 2 approx. =R/sub rho/ 3 m/sub rho/ 3 / f/sub rho/ 2 for the confinement radii (R), masses, and coupling constants (f) of W and rho bosons. Using experimental values for f/sub rho/, m/sub rho/, and M/sub W/ and with f/sub W/ = 0.66, one obtains R/sub W//R/sub rho/approx. =2 x 10 -3 . f/sub rho/, f/sub W/, and masses can be calculated separately

A single residue controls electron transfer gating in photosynthetic reaction centers

Czech Academy of Sciences Publication Activity Database

Shlyk, O.; Samish, I.; Matěnová, M.; Dulebo, A.; Poláková, H.; Kaftan, David; Scherz, A.

2017-01-01

Roč. 7, MAR 16 (2017), s. 1-13, č. článku 44580. ISSN 2045-2322 R&D Projects: GA ČR GA15-00703S; GA MŠk(CZ) LO1416 Institutional support: RVO:61388971 Keywords : BACTERIAL REACTION CENTERS * INDUCED STRUCTURAL-CHANGES * ATOMIC-FORCE MICROSCOPE Subject RIV: EE - Microbiology, Virology OBOR OECD: Microbiology Impact factor: 4.259, year: 2016

77 FR 1656 - Proposed Establishment of Restricted Areas R-5402, R-5403A, R-5403B, R-5403C, R-5403D, R-5403E, R...

Science.gov (United States)

2012-01-11

...-0117; Airspace Docket No. 09-AGL-31] RIN 2120-AI92 Proposed Establishment of Restricted Areas R-5402, R-5403A, R- 5403B, R-5403C, R-5403D, R-5403E, R-5403F; Devils Lake, ND AGENCY: Federal Aviation... Restricted Areas R-5402, R-5403A, R-5403B, R- 5403C, R-5403D, R-5403E, R-5403F; Devils Lake, ND (76 FR 72869...

77 FR 36907 - Establishment of Restricted Areas R-5402, R-5403A, R-5403B, R-5403C, R-5403D, R-5403E, and R...

Science.gov (United States)

2012-06-20

...; Airspace Docket No. 09-AGL-31] Establishment of Restricted Areas R-5402, R-5403A, R-5403B, R- 5403C, R-5403D, R-5403E, and R-5403F; Devils Lake, ND AGENCY: Federal Aviation Administration (FAA), DOT. ACTION... establish Restricted Areas R- 5402, R-5403A, R-5403B, R-5403C, R-5403D, R-5403E, and R-5403F in the vicinity...

EPR study of charge compensation of chromium centers in the strontium titanate crystal

Czech Academy of Sciences Publication Activity Database

Badalyan, A. G.; Azamat, Dmitry; Babunts, R.A.; Neverova, E.V.; Dejneka, Alexandr; Trepakov, Vladimír; Jastrabík, Lubomír

2013-01-01

Roč. 55, č. 7 (2013), 1454-1458 ISSN 1063-7834 R&D Projects: GA ČR GAP108/12/1941 Institutional support: RVO:68378271 Keywords : EPR spectroscopy * SrTiO3:Cr crystal * chromium centers Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.782, year: 2013

VizieR Online Data Catalog: RVs and R-band obs. of the EB* V541 Cyg (Torres+, 2017)

Science.gov (United States)

Torres, G.; McGruder, C. D.; Siverd, R. J.; Rodriguez, J. E.; Pepper, J.; Stevens, D. J.; Stassun, K. G.; Lund, M. B.; James, D.

2017-10-01

V541 Cyg was observed spectroscopically at the Harvard-Smithsonian Center for Astrophysics (CfA) with the Digital Speedometer (DS) on the 1.5m Tillinghast reflector at the Fred L. Whipple Observatory on Mount Hopkins (AZ). We gathered 72 exposures between 2000 July and 2004 October (R~35000). Observations of V541 Cyg were obtained between 2007 May and 2014 November in the course of the Kilodegree Extremely Little Telescope transiting planet program (KELT). The passband of these observations resembles that of a very broad R-band filter. The magnitudes given in tables 2 and 3 are instrumental (not referring to a standard photometric system). (3 data files).

WISC-R Analysis: Implications for Diagnosis and Educational Intervention of LD Children.

Science.gov (United States)

Stevenson, Lillian P.

The study investigated the functional patterns of intellectual performance on the Wechsler Intelligence Scale for Children-Revised (WISC-R) of 55 children (ages 5-to-18 years) referred to a child center to determine if the WISC-R profiles could help identify the children as learning disabled. Secondarily the study utilized the factor-score…

User manual for Blossom statistical package for R

Science.gov (United States)

Talbert, Marian; Cade, Brian S.

2005-01-01

Blossom is an R package with functions for making statistical comparisons with distance-function based permutation tests developed by P.W. Mielke, Jr. and colleagues at Colorado State University (Mielke and Berry, 2001) and for testing parameters estimated in linear models with permutation procedures developed by B. S. Cade and colleagues at the Fort Collins Science Center, U.S. Geological Survey. This manual is intended to provide identical documentation of the statistical methods and interpretations as the manual by Cade and Richards (2005) does for the original Fortran program, but with changes made with respect to command inputs and outputs to reflect the new implementation as a package for R (R Development Core Team, 2012). This implementation in R has allowed for numerous improvements not supported by the Cade and Richards (2005) Fortran implementation, including use of categorical predictor variables in most routines.

The TESS Science Processing Operations Center

Science.gov (United States)

Jenkins, Jon M.; Twicken, Joseph D.; McCauliff, Sean; Campbell, Jennifer; Sanderfer, Dwight; Lung, David; Mansouri-Samani, Masoud; Girouard, Forrest; Tenenbaum, Peter; Klaus, Todd;

How Reverse R&D Knowledge Transfer from Foreign Invested R&D in Emerging Markets Can Drive Global Innovation Performance

DEFF Research Database (Denmark)

Søberg, Peder Veng; Harryson, Sigvald

2010-01-01

is that Windtech took a more open collaboration approach towards other local companies – typically R&D Centers of Western leading companies in relevant industries. This open recruiting policy provided the platform for locally created innovations with global innovation impact....... efforts. A network based theoretical framework is introduced to analyze and explain the impact of globalization of R&D on innovation performance – mainly as a result of local connectivity. Empirically, we explore four company cases to analyze the extent to which their strategic expansion of R&D activities......&D to China. Their university interaction was quite monolateral, mainly based on Robotech donating equipment for university researchers to experiment with. Like Robotech, Windtech did not engage in bilateral university collaborations. One point of differentiation from all other three case companies...

Stanford Linear Accelerator Center selects Verity Ultraseek for public and internal Web Sites

CERN Multimedia

2004-01-01

Verity Inc., a provider of enterprise software has announced the latest version of its powerful, downloadable Verity(R) Ultraseek(R) enterprise search engine is being used by the Stanford Linear Accelerator Center, a research facility funded by the U.S. Department of Energy and operated by Stanford University (1/2 page).

Status of quality assurance system for R and D in BNL

International Nuclear Information System (INIS)

Park, Chan Gook; Lim, Nam Jin; Lee, Young Gun; Kim, Kwan Hyun; Nam, Ji Hee

2003-03-01

This study aims to frame a basic policy for adoption of R and D QA and to guide the improvement of existing nuclear facilities-centered QA systems for regular enforcement of R and D QA in the future. We investigated the state-of-the-art of R and D QA systems in U.S.A where R and D QA is most comprehensively applied in the world. We also investigated the implementation process of QA activities to understand the state of the operation of QA system. The policy for improvement of existing QA systems for regular enforcement of R and D QA in Korea were established through the comparative study of QA system between U.S.A and Korea

Mean centering, multicollinearity, and moderators in multiple regression: The reconciliation redux.

Science.gov (United States)

Iacobucci, Dawn; Schneider, Matthew J; Popovich, Deidre L; Bakamitsos, Georgios A

2017-02-01

In this article, we attempt to clarify our statements regarding the effects of mean centering. In a multiple regression with predictors A, B, and A × B (where A × B serves as an interaction term), mean centering A and B prior to computing the product term can clarify the regression coefficients (which is good) and the overall model fit R 2 will remain undisturbed (which is also good).

Hole centers in γ-irradiated, oxidized Al2O3

International Nuclear Information System (INIS)

Lee, K.H.; Holmberg, G.E.; Crawford, J.H. Jr.

1976-01-01

ESR observations of centers with S = 1/2, g approximately equal to 2, S = 1, g approximately equal to 2 have been made at 77 K on oxidized Al 2 O 3 after γ-irradiation at 30 0 C. From the radiation growth data, it is shown that the S = 1/2 centers are precursors of the S = 1 centers. In addition, when the S = 1 centers anneal out at about 110 0 C, the S = 1/2 centers reappear and eventually anneal out at about 260 0 C. Previously Gamble (Gamble, F.T.; Ph.D. Thesis, U. of Connecticut (1963)) and Cox (Cox, R.T.; Ph.D. Thesis, U. of Grenoble (1972) unpublished), respectively, observed S = 1/2 and S = 1 paramagnetic centers in electron-irradiated nominally pure Al 2 O 3 and γ-irradiated, oxidized, titanium-doped Al 2 O 3 . The models proposed for these centers were one hole and two holes trapped on oxygen ions adjacent to Al 3+ vacancies. Our results further substantiate these models. (author)

A calorimetric and equilibrium investigation of the reaction {l_brace}methyl ferulate(aq) + H{sub 2}O(l) = methanol(aq) + ferulic acid(aq){r_brace}

Energy Technology Data Exchange (ETDEWEB)

Goldberg, Robert N., E-mail: robert.goldberg@nist.go [Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20876 (United States); Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, Baltimore, MD 21250 (United States); Lang, Brian E., E-mail: brian.lang@nist.go [Biochemical Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20876 (United States); Selig, Michael J., E-mail: michael.selig@nrel.go [National Renewable Energy Laboratory, Biosciences Center, 1617 Cole Boulevard, Golden, CO 80401 (United States); Decker, Stephen R., E-mail: steve.decker@nrel.go [National Renewable Energy Laboratory, Biosciences Center, 1617 Cole Boulevard, Golden, CO 80401 (United States)

2011-03-15

Microcalorimetry and high-performance liquid chromatography (HPLC) have been used to conduct a thermodynamic investigation of the reaction: {l_brace}methyl ferulate(aq) + H{sub 2}O(l) = methanol(aq) + ferulic acid(aq){r_brace}, as catalyzed by feruloyl esterase. Values of the apparent equilibrium constant K' = (29.6 {+-} 0.7) (T = 298.15 K, citrate buffer at pH 4.98, ionic strength I = 0.39 mol {center_dot} kg{sup -1}) and of the calorimetrically determined enthalpy of reaction {Delta}{sub r}H(cal) = (4.0 {+-} 0.9) kJ {center_dot} mol{sup -1} (T = 298.15 K and citrate buffer at pH 4.81, I = 0.36 mol {center_dot} kg{sup -1}) were measured. A chemical equilibrium model, together with pKs and standard enthalpies of reaction {Delta}{sub r}H{sup 0} for the H{sup +}(aq) binding reactions of the reactants and products, was then used to calculate the values K = (1.89 {+-} 0.06) . 10{sup -4}, {Delta}{sub r}H{sup o} = (7.3 {+-} 1.7) kJ {center_dot} mol{sup -1}, {Delta}{sub r}G{sup o} = (21.25 {+-} 0.07) kJ {center_dot} mol{sup -1}, and {Delta}{sub r}S{sup o} = - (46.8 {+-} 5.7) J {center_dot} K{sup -1} {center_dot} mol{sup -1} for the chemical reference reaction {l_brace}methyl ferulate(aq) + H{sub 2}O(l) = methanol(aq) + ferulic acid{sup -}(aq) + H{sup +}(aq){r_brace}. These values of K and {Delta}{sub r}H{sup o} are similar in magnitude to the corresponding values reported for the reaction {l_brace}propyl gallate(aq) + H{sub 2}O(l) = 3,4,5-trihydroxybenzoic acid{sup -}(aq) + 1-propanol(aq) + H{sup +}(aq){r_brace}. The results obtained in this study can be used in a chemical equilibrium model to calculate how K' and other standard transformed properties such as the standard transformed enthalpy {Delta}{sub r}H'{sup o}, standard transformed Gibbs free energy {Delta}{sub r}G'{sup o}, and the change in binding of H{sup +}(aq), {Delta}{sub r}N(H{sup +}), vary with the independent variables T, pH, and I.

Rolling Deck to Repository (R2R): Standards and Semantics for Open Access to Research Data

Science.gov (United States)

Arko, Robert; Carbotte, Suzanne; Chandler, Cynthia; Smith, Shawn; Stocks, Karen

2015-04-01

Centers and the EU SeaDataNet project. R2R is a partner in the Ocean Data Interoperability Platform (ODIP), working to strengthen links among regional and national data systems, as well as a lead partner in the EarthCube "GeoLink" project, developing a standard set of ontology design patterns for publishing research data using Semantic Web protocols.

Inherently balanced 4R four-bar based linkages

NARCIS (Netherlands)

van der Wijk, V.; Herder, Justus Laurens; Lenarcis, J.; Husty, M.

2012-01-01

Synthesis of mechanisms with their center of mass (CoM) at an invariant point on one of the elements is useful for the design of statically balanced and shaking-force balanced mechanisms and manipulators. For this purpose, a kinematic architecture based on a general 4R four-bar linkage is found by

78 FR 25469 - Notice of Inventory Completion: University of South Alabama Center for Archaeological Studies...

Science.gov (United States)

2013-05-01

... completion of an inventory of human remains and associated funerary objects under the control of the....R50000] Notice of Inventory Completion: University of South Alabama Center for Archaeological Studies... Alabama Center for Archaeological Studies has completed an inventory of human remains and associated...

Representing Targets of Measurement within Evidence-Centered Design

Science.gov (United States)

Ewing, Maureen; Packman, Sheryl; Hamen, Cynthia; Thurber, Allison Clark

2010-01-01

In the last few years, the Advanced Placement (AP) Program[R] has used evidence-centered assessment design (ECD) to articulate the knowledge, skills, and abilities to be taught in the course and measured on the summative exam for four science courses, three history courses, and six world language courses; its application to calculus and English…

Integrated Support Center for Nuclear Nonproliferation and Security

International Nuclear Information System (INIS)

Kimura, Naohito; Naoi, Yosuke

2010-01-01

international institutional frameworks. The Center will assist emerging nuclear power countries in the development of institutional and technical infrastructures, which are tailored for specific needs and requests. Support for infrastructure development includes the system of safeguards and nuclear security necessary to introduce nuclear power plants, such as the explanation of Japan's legal system in the field of safeguards and nuclear security. The Center will provide the technical assistance necessary to implement safeguards and nuclear security. In addition, the Center will promote non- proliferation R and D and host students for conducting R and D activities. The Center will promote international coordination and collaboration to strengthen nuclear security and non-proliferation. The Center will tailor training and other assistance to country-specific needs. In addition, the Center will communicate and collaborate with international organizations such as the IAEA and EURATOM, and partner countries, such as the United States, Australia, Korea and China. (author)

77 FR 1704 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-01-11

...: Center for Scientific Review Special Emphasis Panel; R15: Musculoskeletal Tissue Engineering, Oral, Bone and Skeletal Muscle Biology. Date: February 7-8, 2012. Time: 8 a.m. to 6 p.m. Agenda: To review and...

Patient satisfaction in Dental Healthcare Centers.

Science.gov (United States)

Ali, Dena A

2016-01-01

This study aimed to (1) measure the degree of patient satisfaction among the clinical and nonclinical dental services offered at specialty dental centers and (2) investigate the factors associated with the degree of overall satisfaction. Four hundred and ninety-seven participants from five dental centers were recruited for this study. Each participant completed a self-administered questionnaire to measure patient satisfaction with clinical and nonclinical dental services. Analysis of variance, t-tests, a general linear model, and stepwise regression analysis was applied. The respondents were generally satisfied, but internal differences were observed. The exhibited highest satisfaction with the dentists' performance, followed by the dental assistants' services, and the lowest satisfaction with the center's physical appearance and accessibility. Females, participants with less than a bachelor's degree, and younger individuals were more satisfied with the clinical and nonclinical dental services. The stepwise regression analysis revealed that the coefficient of determination (R (2)) was 40.4%. The patient satisfaction with the performance of the dentists explained 42.6% of the overall satisfaction, whereas their satisfaction with the clinical setting explained 31.5% of the overall satisfaction. Additional improvements with regard to the accessibility and physical appearance of the dental centers are needed. In addition, interventions regarding accessibility, particularly when booking an appointment, are required.

Soutien organisationnel de la phase 2 de l'ITT : Center for Study of ...

International Development Research Centre (IDRC) Digital Library (Canada)

Ce financement contribuera à renforcer le rôle du Center for Study of Science, Technology and Policy (CSTEP) en tant qu'organisme crédible de recherche sur ... programme réunissant plusieurs bailleurs de fonds qui vise à renforcer les institutions indépendantes de recherche sur les politiques - ou " think tanks " - dans les ...

ICA-based artifact removal diminishes scan site differences in multi-center resting-state fMRI

NARCIS (Netherlands)

R.A. Feis (Rogier A.); S.M. Smith (Stephen); N. Filippini (Nicola); G. Douaud (Gwenaëlle); E.G.P. Dopper (Elise); V. Heise (Verena); A.J. Trachtenberg (Aaron J.); J.C. van Swieten (John); M.A. van Buchem (Mark); S.A.R.B. Rombouts (Serge); C.E. Mackay (Clare E.)

2015-01-01

textabstractResting-state fMRI (R-fMRI) has shown considerable promise in providing potential biomarkers for diagnosis, prognosis and drug response across a range of diseases. Incorporating R-fMRI into multi-center studies is becoming increasingly popular, imposing technical challenges on data

Determination of the absolute configurations at stereogenic centers in the presence of axial chirality.

Science.gov (United States)

Polavarapu, Prasad L; Jeirath, Neha; Kurtán, Tibor; Pescitelli, Gennaro; Krohn, Karsten

2009-01-01

Cephalochromin, a homodimeric naphthpyranone natural product, contains both axial chirality due to the hindered rotation along the biaryl axis and central chirality due to the C-2, C-2' stereogenic centers of the fused pyranone ring. For determining the absolute configurations (ACs) of central chirality elements, different chiroptical spectroscopic methods, namely vibrational circular dichroism (VCD), electronic circular dichroism (ECD), and optical rotation (OR), have been used. From these experimental data, in conjunction with corresponding quantum chemical predictions at B3LYP/6-311G* level, it is found that the ECD spectra of cephalochromin are dominated by its axial chirality and are not suitable to distinguish the (aS,2S,2'S) and (aS,2R,2'R) diastereomers and hence to determine the ACs of the central chirality elements. OR signs also did not distinguish the (aS,2S,2'S) and (aS,2R,2'R) diastereomers. On other hand, VCD spectrum of cephalochromin exhibited separate spectral features attributable to axial chirality and stereogenic centers, thereby allowing the determination of both types of chirality elements. This is the first investigation demonstrating that, because of vibrations specific to the studied stereogenic centers, VCD spectroscopy can be used to simultaneously determine the ACs of axial and central chirality elements whenever other chiroptical methods (ECD and OR) fail to report on them. (c) 2009 Wiley-Liss, Inc.

Religion and Spirituality in Group Counseling: Beliefs and Practices of University Counseling Center Counselors

Science.gov (United States)

Post, Brian C.; Cornish, Marilyn A.; Wade, Nathaniel G.; Tucker, Jeritt R.

2013-01-01

Fifty-four counselors at 9 university counseling centers participated in a study regarding religion and spirituality (R/S) in group counseling. The majority indicated that R/S is an appropriate topic for group counseling and that some religious and spiritual interventions are appropriate to use. However, counselors rarely use these interventions.…

Kinematics of center of mass and center of pressure predict friction requirement at shoe-floor interface during walking.

Science.gov (United States)

Yamaguchi, Takeshi; Yano, Masaru; Onodera, Hiroshi; Hokkirigawa, Kazuo

2013-06-01

We aimed to determine whether inclination angles of the line connecting the whole body center of mass (COM) to the center of pressure (COP) (COM-COP angle) help predict the required coefficient of friction (RCOF) in young adult males during the weight acceptance and push-off phases in transient movements such as turning, gait termination and initiation, and steady-state movements such as straight walking. Seventeen healthy young adult males were asked to (1) walk in a straight line, (2) turn 60° with either foot (step and spin turns), and (3) initiate and terminate walking on a dry level floor. Peak absolute values of the ratio between resultant horizontal and vertical ground reaction forces during the weight acceptance and push-off phases (RCOFh and RCOFt, respectively) were calculated. COM-COP angles θh and θt at the instant of RCOFh and RCOFt, respectively, were also calculated. Bivariate regression analysis demonstrated that the |θh| and |θt| tangents were significant predictors of RCOFh (R = 0.878; R(2) = 0.770; ppush-off phases in steady-state movements such as straight walking and transient movements such as turning as well as gait termination and initiation. Copyright © 2012 Elsevier B.V. All rights reserved.

Overview of direct use R&D at the Geo-Heat Center

Energy Technology Data Exchange (ETDEWEB)

Lienau, P.J.

1997-12-31

Geo-Heat Center research, during the past year, on geothermal district heating and greenhouse projects is intended to improve the design and cost effectiveness of these systems. The largest geothermal district heating system in the U.S., proposed at Reno, is describe and is one of 271 collocated sites in western states could benefit from the research. The geothermal district heating research investigated a variety of factors that could reduce development cost for residential areas. Many greenhouse operators prefer the {open_quotes}bare tube{close_quotes} type heating system. As facilities using these types of heating systems expand they could benefit from peaking with fossil fuels. It is possible to design a geothermal heating system for only 60% of the peak heat loss of a greenhouse and still meet over 90% of the annual heat energy needs of the structure. The design and cost effectiveness of this novel approach is summarized.

Exact solutions to the center-of-mass problem in a model theory

International Nuclear Information System (INIS)

de Forest, T. Jr.

1980-01-01

A model theory, standard time-independent perturbation theory in a harmonic oscillator shell model basis, is used to investigate various aspects of the center-of-mass problem. In this model it is shown that the center-of-mass problem can be solved by projection techniques, but that the way in which one projects is crucial. The appropriate projection functions are found to be const x R/sup -3/2/ for wave function projection and 1 for density projection. The former illustrates, among other things, that the center-of-mass problem cannot be solved by simply eliminating the spurious components of the wave function. The latter agrees with the Gartenhaus-Schwartz prescription. Also, explicit center-of-mass corrections are calculated

Interaction of charged 3D soliton with Coulomb center

International Nuclear Information System (INIS)

Rybakov, Yu.P.

1996-03-01

The Einstein - de Broglie particle-soliton concept is applied to simulate stationary states of an electron in a hydrogen atom. According to this concept, the electron is described by the localized regular solutions to some nonlinear equations. In the framework of Synge model for interacting scalar and electromagnetic fields a system of integral equations has been obtained, which describes the interaction between charged 3D soliton and Coulomb center. The asymptotic expressions for physical fields, describing soliton moving around the fixed Coulomb center, have been obtained with the help of integral equations. It is shown that the electron-soliton center travels along some stationary orbit around the Coulomb center. The electromagnetic radiation is absent as the Poynting vector has non-wave asymptote O(r -3 ) after averaging over angles, i.e. the existence of spherical surface corresponding to null Poynting vector stream, has been proved. Vector lines for Poynting vector are constructed in asymptotical area. (author). 22 refs, 2 figs

Decommissioning Operations at the Cadarache Nuclear Research Center

International Nuclear Information System (INIS)

Gouhier, E.

2008-01-01

Among the different activities of the CEA research center of Cadarache, located in the south of France, one of the most important involves decommissioning. As old facilities close, decommissioning activity increases. This presentation will give an overview of the existing organization and the different ongoing decommissioning and cleanup operations on the site. We shall also present some of the new facilities under construction the purpose of which is to replace the decommissioned ones. Cadarache research center was created on October 14, 1959. Today, the activities of the research center are shared out among several technological R and D platforms, essentially devoted to nuclear energy (fission and fusion) Acting as a support to these R and D activities, the center of Cadarache has a platform of services which groups the auxiliary services required by the nuclear facilities and those necessary to the management of nuclear materials, waste, nuclear facility releases and decommissioning. Many old facilities have shut down in recent years (replaced by new facilities) and a whole decommissioning program is now underway involving the dismantling of nuclear reactors (Rapsodie, Harmonie), processing facilities (ATUE uranium treatment facility, LECA UO 2 facility) as well as waste treatment and storage facilities (INB37, INB 56. In conclusion: other dismantling and cleanup operations that are now underway in Cadarache include the following: - Waste treatment and storage facilities, - Historical VLLW and HLW storage facility, - Fissile material storage building, - Historical spent fuel storage facility. Thanks to the project organization: - Costs and risks on these projects can be reduced. - Engineers and technicians can easily move from one project to another. In some cases, when a new facility is under construction for the purpose of replacing a decommissioned one, some of the project team can integrate the new facility as members of the operation team. Today

77 FR 28397 - Center for Scientific Review Notice of Closed Meetings

Science.gov (United States)

2012-05-14

...: Integrative, Functional and Cognitive Neuroscience Integrated Review Group, Somatosensory and Chemosensory....gov . Name of Committee: Integrative, Functional and Cognitive Neuroscience Integrated Review Group..., [email protected] . Name of Committee: Center for Scientific Review Special Emphasis Panel, AREA (R15...

Structures and Infrastructures of International R&D Networks: A Capability Maturity Perspective

DEFF Research Database (Denmark)

Niang, Mohamed; Wæhrens, Brian Vejrum

Purpose: This paper explores the process towards globally distributing R&D activities with an emphasis on organizational maturity. It discusses emerging configurations by asking how the structure and infrastructure of international R&D networks evolve along with the move from a strong R&D center...... to dispersed development. Design/Methodology/Approach: This is a qualitative study of the process of distributing R&D. By comparing selected firms, the researchers identify a pattern of dispersion of R&D activities in three Danish firms. Findings and Discussion: Drawing from the case studies, the researchers...... present a capability maturity model. Furthermore, understanding the interaction between new structures and infrastructures of the dispersed networks is viewed as a key requirement for developing organizational capabilities and formulating adequate strategies that leverage dispersed R&D. Organizational...

78 FR 50108 - Notice of Intent To Repatriate Cultural Item: Rochester Museum & Science Center, Rochester, NY

Science.gov (United States)

2013-08-16

....R50000] Notice of Intent To Repatriate Cultural Item: Rochester Museum & Science Center, Rochester, NY AGENCY: National Park Service, Interior. ACTION: Notice. SUMMARY: The Rochester Museum & Science Center... that the cultural item listed in this notice meets the definition of a sacred object and an object of...

76 FR 72869 - Proposed Establishment of Restricted Areas R-5402, R-5403A, R-5403B, R-5403C, R-5403D, R-5403E...

Science.gov (United States)

2011-11-28

...-0117; Airspace Docket No. 09-AGL-31] Proposed Establishment of Restricted Areas R-5402, R-5403A, R- 5403B, R-5403C, R-5403D, R-5403E, and R-5403F; Devils Lake, ND AGENCY: Federal Aviation Administration... Camp Grafton Range, the existing R-5401 restricted area surrounding the range is inadequate to satisfy...

The Rise of Federally Funded Research and Development Centers

Energy Technology Data Exchange (ETDEWEB)

DALE,BRUCE C.; MOY,TIMOTHY D.

2000-09-01

Federally funded research and development centers (FFRDCS) area unique class of research and development (R and D) facilities that share aspects of private and public ownership. Some FFRDCS have been praised as national treasures, but FFRDCS have also been the focus of much criticism through the years. This paper traces the history of FFRDCS through four periods: (1) the World War II era, which saw the birth of federal R and D centers that would eventually become FFRDCS; (2) the early Cold War period, which exhibited a proliferation of FFRDCS despite their unclear legislative status and growing tension with an increasingly capable and assertive defense industry, (3) there-evaluation and retrenchment of FFRDCS in the 1960s and early 1970s, which resulted in a dramatic decline in the number of FFRDCS; and (4) the definition and codification of the FFRDC entity in the late 1970s and 1980s, when Congress and the executive branch worked together to formalize regulations to control FFRDCS. The paper concludes with observations on the status of FFRDCS at the end of the twentieth century.

Interaction of pleuromutilin derivatives with the ribosomal peptidyl transferase center

DEFF Research Database (Denmark)

Long, K. S.; Hansen, L. K.; Jakobsen, L.

2006-01-01

Tiamulin is a pleuromutilin antibiotic that is used in veterinary medicine. The recently published crystal structure of a tiamulin-50S ribosomal subunit complex provides detailed information about how this drug targets the peptidyl transferase center of the ribosome. To promote rational design...... mutant strain is resistant to tiamulin and pleuromutilin, but not valnemulin, implying that valnemulin is better able to withstand an altered rRNA binding surface around the mutilin core. This is likely due to additional interactions made between the valnemulin side chain extension and the rRNA binding...

Magnetic Field Sensing with Nitrogen-Vacancy Color Centers in Diamond

Science.gov (United States)

2013-05-01

8217d from r.haracteristic time of the der.ay enwlop<’. as shown in Figm<’ 1.7(b). For an ensemble of NV centers , inhomogeneities stemming from the...Backgnmnd a initialization detection optical _.J:.D ____. __________ __._n....__ b 350 "E 300 ~ 250 (jj §, 200 Cll Ŕ 150 l!l ~ 100 ~ 50 0...Free Precession Time-r (J.IS) II) ---(ij c .2’ (/) Cll (J c :!l e 0 ::J u: 0 0.5 15 2 Static Magnetic Field B (G) Figurr A. 2

78 FR 35292 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-06-12

...: Functional Epigenomics: Developing Tools and Technologies for Manipulation of the Epigenome (R01). Date: July... Special Emphasis Panel; Member Conflict: Genome Integrity and Tumor Progression. Date: July 11, 2013. Time....gov . Name of Committee: Center for Scientific Review Special Emphasis Panel; Member Conflict...

System performance with R407A, R407B, R407C compared to R22

DEFF Research Database (Denmark)

Knudsen, Hans Jørgen Høgaard

1997-01-01

both the cooling capacity and COP are smaller then the cooling capacity and COP with R22. The cooling capacity for R407A and R407B is lower than the capacity for R22 for brine temperatures less than 0 C and higher then the cooling capacity for R22 for brine temperatures higher than 0 C. The COP for R......407A and R407B er lower than the COP for R22.The volumetric and isentropic efficiency of the compressor are with mixture higher than the volumetric and isentropic efficiency with R22.......The article presents the results obtained by substituting R22 with mixture of R32/R125/R134A (R407A, R407B and R407C) in an existing refrigeration plant. Cooling capacity, coefficient of performance and heat transfer coefficient in the evaporator have been measured.The results show that for R407C...

NBR ISO 9001 Certification for activities carried out in IEA-R1 reactor

International Nuclear Information System (INIS)

Paiva, Rosemeire P.; Salvetti, Tereza C.

2005-01-01

Since its inauguration in 1957, the IEA-R1 research reactor has been used mainly for research, development and teaching by scientific community. In the last years, with the increase of the commercial radiopharmaceutical production by Radiopharmacy Center of IPEN, the IEA-R1 reactor was recognized as a service supplier for that center and has received a treatment more commercial from IPEN Management. In 1999 the radiopharmaceutical production obtained the NBR ISO 9002 Certification, since that the IPEN Management considered convenient to invest in the certification of its internal suppliers. In this context, in 2001 the Research Reactor Center (CRPq) began the implantation of a Quality Management System (QMS) based on NBR 9001: 2000 standard, for activities related to the operation and maintenance of the IEA-R1 research reactor and irradiation services. This QMS was structured to incorporate tools already implemented in order to complain the requirements related to nuclear and radiological safe for a nuclear installation established by the regulatory organism. The QMS is supported by a documentation system composed of approximately 150 documents including quality manual, business and action plans, operational procedures and work instruction. Carlos Alberto Vanzolini Foundation (FCAV), an INMETRO certified organism, certified the 'Operation and Maintenance of the IEA-R1 Research Reactor and Irradiation Services' in December 2002. In 2003 and 2004, the QMS was audited by FCAV that determined the maintenance of the certification. This work presents the main steps of the QMS implementation, including the difficulties found and results obtained in the process. (author)

Evaluating trauma center structural performance: The experience of a Canadian provincial trauma system

Directory of Open Access Journals (Sweden)

Lynne Moore

2013-01-01

Full Text Available Background: Indicators of structure, process, and outcome are required to evaluate the performance of trauma centers to improve the quality and efficiency of care. While periodic external accreditation visits are part of most trauma systems, a quantitative indicator of structural performance has yet to be proposed. The objective of this study was to develop and validate a trauma center structural performance indicator using accreditation report data. Materials and Methods: Analyses were based on accreditation reports completed during on-site visits in the Quebec trauma system (1994-2005. Qualitative report data was retrospectively transposed onto an evaluation grid and the weighted average of grid items was used to quantify performance. The indicator of structural performance was evaluated in terms of test-retest reliability (kappa statistic, discrimination between centers (coefficient of variation, content validity (correlation with accreditation decision, designation level, and patient volume and forecasting (correlation between visits performed in 1994-1999 and 1998-2005. Results: Kappa statistics were >0.8 for 66 of the 73 (90% grid items. Mean structural performance score over 59 trauma centers was 47.4 (95% CI: 43.6-51.1. Two centers were flagged as outliers and the coefficient of variation was 31.2% (95% CI: 25.5% to 37.6%, showing good discrimination. Correlation coefficients of associations with accreditation decision, designation level, and volume were all statistically significant (r = 0.61, -0.40, and 0.24, respectively. No correlation was observed over time (r = 0.03. Conclusion: This study demonstrates the feasibility of quantifying trauma center structural performance using accreditation reports. The proposed performance indicator shows good test-retest reliability, between-center discrimination, and construct validity. The observed variability in structural performance across centers and over-time underlines the importance of

NASA's National Center for Advanced Manufacturing

Science.gov (United States)

Vickers, John

2003-01-01

NASA has designated the Principal Center Assignment to the Marshall Space Flight Center (MSFC) for implementation of the National Center for Advanced Manufacturing (NCAM). NCAM is NASA s leading resource for the aerospace manufacturing research, development, and innovation needs that are critical to the goals of the Agency. Through this initiative NCAM s people work together with government, industry, and academia to ensure the technology base and national infrastructure are available to develop innovative manufacturing technologies with broad application to NASA Enterprise programs, and U.S. industry. Educational enhancements are ever-present within the NCAM focus to promote research, to inspire participation and to support education and training in manufacturing. Many important accomplishments took place during 2002. Through NCAM, NASA was among five federal agencies involved in manufacturing research and development (R&D) to launch a major effort to exchange information and cooperate directly to enhance the payoffs from federal investments. The Government Agencies Technology Exchange in Manufacturing (GATE-M) is the only active effort to specifically and comprehensively address manufacturing R&D across the federal government. Participating agencies include the departments of Commerce (represented by the National Institute of Standards and Technology), Defense, and Energy, as well as the National Science Foundation and NASA. MSFC s ongoing partnership with the State of Louisiana, the University of New Orleans, and Lockheed Martin Corporation at the Michoud Assembly Facility (MAF) progressed significantly. Major capital investments were initiated for world-class equipment additions including a universal friction stir welding system, composite fiber placement machine, five-axis machining center, and ten-axis laser ultrasonic nondestructive test system. The NCAM consortium of five universities led by University of New Orleans with Mississippi State University

Center for computer security: Computer Security Group conference. Summary

Energy Technology Data Exchange (ETDEWEB)

None

1982-06-01

Topics covered include: computer security management; detection and prevention of computer misuse; certification and accreditation; protection of computer security, perspective from a program office; risk analysis; secure accreditation systems; data base security; implementing R and D; key notarization system; DOD computer security center; the Sandia experience; inspector general's report; and backup and contingency planning. (GHT)

Stern-Center Potsdam; Stern-Center Potsdam

Energy Technology Data Exchange (ETDEWEB)

Anon.

1999-07-01

The ''Stern-Center Potsdam'' is a star-shaped shopping mall in the city center. [German] Das Stern-Center in Potsdam bietet als Einkaufszentrum vor den Toren Berlins Platz fuer eine Vielzahl von Geschaeften. Die sternfoermige Gebaeudestruktur des Centers bildet den Mittelpunkt des Stadtviertels 'Am Stern'. (orig.)

System performance with R407A, R407B, R407C compared to R22

DEFF Research Database (Denmark)

Knudsen, Hans Jørgen Høgaard

1997-01-01

been determined.The results show that for R407C both the cooling capacity and the COP are smaller than the cooling capacity and COP for R22. The cooling capacity for R407A and for R407B is lower then the cooling capacity for R22 for brine temperatures less than 0 C and higher than the capacity for R22...... for brine temperatures higher than 0 C. The COP for R407A and 407B are lower than the COP for R22.The volumetriv and isentropic efficiency of the compressor are with mixtures higher than the volumetric and isentropic efficiency with R22.......The paper presents the results obtained by substituting R22 with mixtures of R32/R124/134a (R407A, R407B and R407C) in an existing refrigeration plant. The cooling water flow and cooling water inlet temperature together with the brine flow and brine inlet temperature have been kept on a value...

Generation characteristics of photovoltaic power generation equipment at TEPCO R and D center; Gijutsu kaihatsu center taiyoko hatsuden setsubi no hatsuden tokusei

Energy Technology Data Exchange (ETDEWEB)

Amano, K; Natori, K [Tokyo Electric Power Co. Inc., Tokyo (Japan)

1997-11-25

Solar battery arrays are installed at different tilt angles for actual measurement in an experiment conducted by TEPCO (Tokyo Electric Power Company, Inc.) Research and Development Center for the examination of their power generation characteristics. Arrays of polycrystalline silicon solar battery modules are positioned facing a direction +7 degrees swung from the south on the Center rooftop and verandah, and they are installed at tilt angles of 0, 30, 60, and 90 degrees. An analysis of system characteristics is conducted, and findings mentioned below are obtained. In fiscal 1996, the highest utilization factor of a yearly average of 11.3% is attained with the ones tilted at 30 degrees. As for the utilization factors at the other angles, they are 10.2% at 60 degrees, 8.8% at 0 degrees, and 8.0% at 90 degrees. The integrated design coefficient remains approximately constant irrespective of the different tilt angles of 0, 30, and 60 degrees. The overall design coefficient of the 90 degree-tilted array installed on the verandah is found to be 0.75, which is higher than those exhibited by the others. Appropriate routes of wirings for modules should be worked out to avoid the ill effect of the shadows of steel towers. 2 refs., 11 figs.

Intrinsic trapping and recombination centers in CdWO.sub.4./sub. investigated using thermally stimulated luminescence

Czech Academy of Sciences Publication Activity Database

Vedda, A.; Moretti, F.; Fasoli, M.; Nikl, Martin; Laguta, Valentyn

2009-01-01

Roč. 80, č. 4 (2009), 045104/1-045104/7 ISSN 1098-0121 R&D Projects: GA AV ČR IAA100100810 Institutional research plan: CEZ:AV0Z10100521 Keywords : CdWO 4 * thermoluminescence * traps * rekombination centers Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 3.475, year: 2009

Electron spin-lattice relaxation of low-symmetry Ni.sup.2+./sup. centers in LiF

Czech Academy of Sciences Publication Activity Database

Azamat, Dmitry; Badalyan, A. G.; Dejneka, Alexandr; Jastrabík, Lubomír; Lančok, Ján

2014-01-01

Roč. 104, č. 25 (2014), "252902-1"-"252902-4" ISSN 0003-6951 R&D Projects: GA MŠk(CZ) LM2011029; GA TA ČR TA01010517; GA ČR GAP108/12/1941 Grant - others:SAFMAT(XE) CZ.2.16/3.1.00/22132 Institutional support: RVO:68378271 Keywords : Ni 2+ centers * LiF single crystals * electron spin-lattice relaxation * electron spin echo technique Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 3.302, year: 2014

76 FR 10910 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2011-02-28

... Committee: Center for Scientific Review Special Emphasis Panel; RFA-HD-11-101: Sleep and Social Environment... Emphasis Panel; RFA-HD-11-102: Sleep and Social Environment: Basic Biopsychosocial Processes (R21). Date... . (Catalogue of Federal Domestic Assistance Program Nos. 93.306, Comparative Medicine; 93.333, Clinical...

Information sharing guidebook for transportation management centers, emergency operations centers, and fusion centers

Science.gov (United States)

2010-06-01

This guidebook provides an overview of the mission and functions of transportation management centers, emergency operations centers, and fusion centers. The guidebook focuses on the types of information these centers produce and manage and how the sh...

Information sharing guidebook for transportation management centers, emergency operations centers, and fusion centers.

Science.gov (United States)

2010-06-01

This guidebook provides an overview of the mission and functions of transportation management centers, emergency operations centers, and fusion centers. The guidebook focuses on the types of information these centers produce and manage and how the sh...

Synovial tissue sublining CD68 expression is a biomarker of therapeutic response in rheumatoid arthritis clinical trials: consistency across centers.

LENUS (Irish Health Repository)

Bresnihan, Barry

2012-02-01

OBJECTIVE: To determine whether the correlation between the mean change in disease activity and the mean change in synovial sublining (sl) CD68 expression could be demonstrated across different academic centers. METHODS: Synovial biopsies obtained at arthroscopy from patients with rheumatoid arthritis before and 160 days after rituximab therapy were selected and coded. Paired sections were processed independently at Amsterdam Medical Center (AMC) and at St. Vincent\\'s University Hospital (SVUH), Dublin. Digital image analysis (DIA) was employed at both centers to quantify sublining CD68 expression. RESULTS: After analysis of CD68sl expression at centers in 2 different countries, high levels of intracenter and intercenter agreement were observed. For the pooled sections stained at AMC, the correlation between 2 investigators was R = 0.942, p = 0.000, and for sections stained at SVUH, R = 0.899, p = 0.001. Similarly, the intracenter correlations for DeltaCD68sl expression after treatment were R = 0.998, p = 0.000, for sections stained at AMC and R = 0.880, p = 0.000, for sections stained at SVUH. The intercenter correlation for the pooled scores of sections stained at AMC was R = 0.85, p = 0.000, and for the sections stained at SVUH, R = 0.62, p = 0.001. The consistent correlation between DeltaDAS (Disease Activity Score) and DeltaCD68sl expression across different studies (Pearson correlation = 0.895, p < 0.001) was confirmed. The standardized response mean values for DeltaCD68sl, calculated from analyses at both AMC and SVUH, were consistently 0.5 or greater, indicating a moderate to high potential to detect change. CONCLUSION: The correlation between mean DeltaDAS and mean DeltaCD68sl expression was confirmed across 2 centers. Examination of serial biopsy samples can be used reliably to screen for interesting biological effects at the site of inflammation at an early stage of drug development.

Biomimetic Membranes for Multi-Redox Center Proteins

Directory of Open Access Journals (Sweden)

Renate L. C. Naumann

2016-03-01

Full Text Available His-tag technology was applied for biosensing purposes involving multi-redox center proteins (MRPs. An overview is presented on various surfaces ranging from flat to spherical and modified with linker molecules with nitrile-tri-acetic acid (NTA terminal groups to bind his-tagged proteins in a strict orientation. The bound proteins are submitted to in situ dialysis in the presence of lipid micelles to form a so-called protein-tethered bilayer lipid membrane (ptBLM. MRPs, such as the cytochrome c oxidase (CcO from R. sphaeroides and P. denitrificans, as well as photosynthetic reactions centers (RCs from R. sphaeroides, were thus investigated. Electrochemical and surface-sensitive optical techniques, such as surface plasmon resonance, surface plasmon-enhanced fluorescence, surface-enhanced infrared absorption spectroscopy (SEIRAS and surface-enhanced resonance Raman spectroscopy (SERRS, were employed in the case of the ptBLM structure on flat surfaces. Spherical particles ranging from µm size agarose gel beads to nm size nanoparticles modified in a similar fashion were called proteo-lipobeads (PLBs. The particles were investigated by laser-scanning confocal fluorescence microscopy (LSM and UV/Vis spectroscopy. Electron and proton transfer through the proteins were demonstrated to take place, which was strongly affected by the membrane potential. MRPs can thus be used for biosensing purposes under quasi-physiological conditions.

Analytical computation of thermodynamic performance parameters of actual vapour compression refrigeration system with R22, R32, R134a, R152a, R290 and R1270

Directory of Open Access Journals (Sweden)

Vali Shaik Sharmas

2018-01-01

Full Text Available The present work focuses on analytical computation of thermodynamic performance of actual vapour compression refrigeration system by using six pure refrigerants. The refrigerants are namely R22, R32, R134a, R152a, R290 and R1270 respectively. A MATLAB code is developed to compute the thermodynamic performance parameters of actual vapour compression system such as refrigeration effect, compressor work, COP, power per ton of refrigeration, compressor discharge temperature and volumetric refrigeration capacity at condensing and evaporating temperatures of 54.4oC and 7.2oC respectively. Analytical results exhibited that COP of both R32 and R134a are 15.95% and 11.71% higher among the six investigated refrigerants. However R32 and R134a cannot be replaced directly into R22 system. This is due to their higher compressor discharge temperature and poor volumetric capacity respectively. The discharge temperature of both R1270 and R290 are lower than R22 by 20-26oC. Volumetric refrigeration capacity of R1270 (3197 kJ/m3 is very close to that of volumetric capacity of R22 (3251 kJ/m3. Both R1270 and R290 shows good miscibility with R22 mineral oil. Overall R1270 would be a suitable ecofriendly refrigerant to replace R22 from the stand point of ODP, GWP, volumetric capacity, discharge temperature and miscibility with mineral oil although its COP is lower.

Preventing droplet deformation during dielectrophoretic centering of a compound emulsion droplet

Science.gov (United States)

Randall, Greg; Blue, Brent

2012-11-01

Compound droplets, or droplets-within-droplets, are traditionally key components in applications ranging from drug delivery to the food industry. Presently, millimeter-sized compound droplets are precursors for shell targets in inertial fusion energy work. However, a key constraint in target fabrication is a uniform shell wall thickness, which in turn requires a centered core droplet in the compound droplet precursor. Previously, Bei et al. (2009, 2010) have shown that compound droplets could be centered in a static fluid using an electric field of 0.7 kV/cm at 20 MHz. Randall et al. (2012) developed a process to center the core of a moving compound droplet, though the ~kV/cm field induced small (fluid mechanics and interfacial rheology perspective and we discuss the effective interfacial charge from an emulsifier and its impact on centering. Work funded by General Atomics Internal R&D.

A Proposal for the Establishment of a Center of Excellence in Theoretical Geoplasma Research.

Science.gov (United States)

1987-11-15

activities at the Center. % % rS The Center is fully staffed with fifteen (15) active members. These - include members of the faculty, staff...the HAPI instrument on Dynamics Explorer 1 on Nov. 14, 1981 at the geocentric altitude of 2 .ORE and Invariant latitude of 600. The top panel... staffed with fifteen participating faculty, staff, postdoctoral and graduate students, and visiting scientists. 0 Throughout the year, we have kept a

Defect model of a tetragonal Sm sup 3 sup + center found from EPR measurements in CaF sub 2 and SrF sub 2 crystals

CERN Document Server

Zheng Wen Chen; Wu Shao Yi; Tang Sheng

2003-01-01

The EPR parameters (g factors g sub p sub a sub r sub a sub l sub l sub e sub l , g sub p sub e sub r sub p sub e sub n sub d sub i sub c sub u sub l sub a sub r sub t sub o and hyperfine structure constants A sub p sub a sub r sub a sub l sub l sub e sub l , A sub p sub e sub r sub p sub e sub n sub d sub i sub c sub u sub l sub a sub r sub t sub o) of a tetragonal (C sub 4 sub v) Sm sup 3 sup + center in CaF sub 2 and SrF sub 2 crystals are calculated by considering the crystal-field J-mixing among the ground sup 6 H sub 5 sub / sub 2 , the first excited sup 6 H sub 7 sub / sub 2 and second excited sup 6 H sub 9 sub / sub 2 state multiplets. In the calculations the free-ion and crystal-field parameters of the tetragonal Sm sup 3 sup + -F sup - center obtained from polarized laser-selective excitation spectroscopy are used. The calculated results suggest that the tetragonal Sm sup 3 sup + -F sup - center is the Sm sup 3 sup + center found by later EPR measurements. The g factors g sub p sub a sub r sub a sub...

LSS-GAC - A LAMOST Spectroscopic Survey of the Galactic Anti-center

Science.gov (United States)

Liu, X.-W.; Yuan, H.-B.; Huo, Z.-Y.; Deng, L.-C.; Hou, J.-L.; Zhao, Y.-H.; Zhao, G.; Shi, J.-R.; Luo, A.-L.; Xiang, M.-S.; Zhang, H.-H.; Huang, Y.; Zhang, H.-W.

2014-01-01

As a major component of the LAMOST Galactic surveys, the LAMOST Spectroscopic Survey of the Galactic Anti-center (LSS-GAC) will survey a significant volume of the Galactic thin/thick disks and halo in a contiguous sky area of ~3,400 sq.deg., centered on the Galactic anti-center (|b| ~ 3 M stars of all colors, uniformly and randomly selected from (r, g - r) and (r, r - i) Hess diagrams obtained from a CCD imaging photometric survey of ~5,400 sq.deg. with the Xuyi 1.04/1.20 m Schmidt Telescope, ranging from r = 14.0 to a limiting magnitude of r = 17.8 (18.5 for limited fields). The survey will deliver spectral classification, radial velocity (V r) and stellar parameters (effective temperature (T eff), surface gravity (log g) and metallicity [Fe/H]) for millions of Galactic stars. Together with Gaia which will provide accurate distances and tangential velocities for a billion stars, the LSS-GAC will yield a unique data set to study the stellar populations, chemical composition, kinematics and structure of the disks and their interface with the halo, identify streams of debris of tidally disrupted dwarf galaxies and clusters, probe the gravitational potential and dark matter distribution, map the 3D distribution of interstellar dust extinction, search for rare objects (e.g. extremely metal-poor or hyper-velocity stars), and ultimately advance our understanding of the assemblage of the Milky Way and other galaxies and the origin of regularity and diversity of their properties. The survey was initiated in the fall of 2012 and expected to complete in the spring of 2017. Hitherto, about 0.4 M spectra of S/N(λ7450) >= 10 per pixel have been accumulated. In addition, bright nights have been used to target stars brighter than 14 mag and have so far generated over 0.4 M spectra, yielding an excellent sample of local stars to probe the solar neighborhood. LSP3, a set of pipelines tailored to the need of LSS-GAC, for spectral flux-calibration, and radial velocity and stellar

Partial synthesis of (3R,6'R)-alpha-cryptoxanthin and (3R)-beta-cryptoxanthin from (3R,3'R,6'R)-lutein.

Science.gov (United States)

Khachik, Frederick; Chang, An-Ni; Gana, Audry; Mazzola, Eugene

2007-02-01

(3R,3'R,6'R)-Lutein (1), (3R,3'R)-zeaxanthin (2), (3R,6'R)-alpha-cryptoxanthin (3), and (3R)-beta-cryptoxanthin (4) are among dietary hydroxycarotenoids that have been identified in human serum, milk, and ocular tissues. While 1 containing 6% of 2 is commercially available, industrial production of optically active 3 and 4 has not yet been accomplished. Several processes have been developed that transform 1 into 3, 4, and minor quantities of (3R,5'RS,6'R)-3',4'-didehydro-5',6'-dihydro-beta,beta-caroten-3-ol (5) (a regioisomer of 3). In one process, lutein (1) was cleanly deoxygenated to 3 in the presence of trifluoroacetic acid (TFA) and Me3N.BH3 in CH2Cl2 at ambient temperature in nearly 90% yield. Reaction of lutein (1) with a Lewis acid (AlCl3, ZnBr2, ZnI2) and a hydride donor (Me3N.BH3, Na[BH3(OCOCF3)], NaCNBH3) in solvents such as CH2Cl2, THF, and TBME produced similar results. In a two-step process, high-temperature acid-catalyzed dehydration of 1 (propanol/water/acid, 90 degrees C) gave a mixture of anhydroluteins 6, 7, and 8 in 86% yield. In the second step, these dehydration products underwent ionic hydrogenation with TFA/Me3N.BH3 in CH2Cl2 to afford a mixture of 3 and 4 in nearly 80% yield that contained only 1% of 5.

Primordial Black Holes and r-Process Nucleosynthesis.

Science.gov (United States)

Fuller, George M; Kusenko, Alexander; Takhistov, Volodymyr

2017-08-11

We show that some or all of the inventory of r-process nucleosynthesis can be produced in interactions of primordial black holes (PBHs) with neutron stars (NSs) if PBHs with masses 10^{-14}  M_{⊙}center of the NS and consumes it from the inside. When this occurs in a rotating millisecond-period NS, the resulting spin-up ejects ∼0.1  M_{⊙}-0.5  M_{⊙} of relatively cold neutron-rich material. This ejection process and the accompanying decompression and decay of nuclear matter can produce electromagnetic transients, such as a kilonova-type afterglow and fast radio bursts. These transients are not accompanied by significant gravitational radiation or neutrinos, allowing such events to be differentiated from compact object mergers occurring within the distance sensitivity limits of gravitational-wave observatories. The PBH-NS destruction scenario is consistent with pulsar and NS statistics, the dark-matter content, and spatial distributions in the Galaxy and ultrafaint dwarfs, as well as with the r-process content and evolution histories in these sites. Ejected matter is heated by beta decay, which leads to emission of positrons in an amount consistent with the observed 511-keV line from the Galactic center.

Diagnostic and prognostic potential of serum miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429 in ovarian cancer patients.

Science.gov (United States)

Meng, Xiaodan; Joosse, Simon A; Müller, Volkmar; Trillsch, Fabian; Milde-Langosch, Karin; Mahner, Sven; Geffken, Maria; Pantel, Klaus; Schwarzenbach, Heidi

2015-11-03

Owing to late diagnosis in advanced disease stages, prognosis of patients with epithelial ovarian cancer (EOC) is poor. The quantification of deregulated levels of microRNAs could facilitate earlier diagnosis and improve prognosis of EOC. Seven microRNAs (miR-7, miR-16, miR-25, miR-93, miR-182, miR-376a and miR-429) were quantified in the serum of 180 EOC patients and 66 healthy women by TaqMan PCR microRNA assays. Median follow-up time was 21 months. The effects of miR-7 and miR-429 on apoptosis, cell proliferation, migration and invasion were investigated in two (EOC) cell lines. Serum levels of miR-25 (P=0.0001) and miR-93 (P=0.0001) were downregulated, whereas those of miR-7 (P=0.001) and miR-429 (P=0.0001) were upregulated in EOC patients compared with healthy women. The four microRNAs discriminated EOC patients from healthy women with a sensitivity of 93% and a specificity of 92%. The levels of miR-429 positively correlated with CA125 values (P=0.0001) and differed between FIGO I-II and III-IV stages (P=0.001). MiR-429 was an independent predictor of overall survival (P=0.011). Overexpressed miR-429 in SKOV3 cells led to suppression of cell migration (P=0.037) and invasion (P=0.011). Increased levels of miR-7 were associated with lymph node metastases (P=0.0001) and FIGO stages III-IV (P=0.0001). Overexpressed miR-7 in SKOV3 cells resulted in increased cell migration (P=0.001) and invasion (P=0.011). Additionally, the increased levels of miR-376a correlated with FIGO stages III-IV (P=0.02). Our data indicate the diagnostic potential of miR-7, miR-25, miR-93 and miR-429 in EOC and the prognostic potential of miR-429. This microRNA panel may be promising molecules to be targeted in the treatment of EOC.

R-hyper-CVAD versus R-CHOP/cytarabine with high-dose therapy and autologous haematopoietic stem cell support in fit patients with mantle cell lymphoma: 20 years of single-center experience.

Science.gov (United States)

Widmer, Fabienne; Balabanov, Stefan; Soldini, Davide; Samaras, Panagiotis; Gerber, Bernhard; Manz, Markus G; Goede, Jeroen S

2018-02-01

Standard of care for untreated mantle cell lymphoma (MCL) is still debated. At the University Hospital Zurich, advanced MCL in physically fit patients is treated either with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisone induction followed by consolidating high-dose chemotherapy and autologous stem cell support (R-CHOP/HD-ASCT), or with rituximab plus fractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone alternating with high-dose methotrexate-cytarabine (R-hyper-CVAD/MTX-AraC) without consolidating HD-ASCT upon physicians' and patients' choice. We retrospectively analysed the outcome and therapy tolerance in patients with MCL treated with R-CHOP/HD-ASCT or R-hyper-CVAD/MTX-AraC at the University Hospital Zurich between January 1996 and January 2016. Forty-three patients were included; 29 patients received R-CHOP/HD-ASCT and 14 patients R-hyper-CVAD/MTX-AraC. Mean age at diagnosis was 54.4 years (range 38-68 years). Thirty-five patients (81.4%) completed the entire first-line therapy (n = 24 in the R-CHOP/HD-ASCT group, n = 11 in the R-hyper-CVAD group). Of those, all patients responded and 97% achieved a complete remission (CR). With a mean follow-up of 5.7 years 10-year progression-free survival (PFS) for all patients was 32% and overall survival (OS) was 76%, with no difference between the two therapy groups. Complication-induced hospitalisation rate, haematological toxicity and economic burden were significantly higher in the R-hyper-CVAD therapy group. In contrast, quality of life and global health state were better in the R-hyper-CVAD therapy group. Both first-line therapies showed similar outcome with a median OS longer than 10 years. Due to significantly lower haematological toxicity and lower economic burden, we recommend R-CHOP/HD-ASCT as first-line therapy in fit adult patients with advanced MCL.

Bituminization of radioactive wastes at the Nuclear Research Center Karlsruhe

International Nuclear Information System (INIS)

Hild, W.; Kluger, W.; Krause, H.

1976-05-01

A summary is given of the main operational experience gained at the Nuclear Research Center Karlsruhe in 4 years operation of the bituminization plant for evaporator concentrates from low- and medium level wastes. At the same time some of the essential results are compiled that have been obtained in the R + D activities on bituminization. (orig.) [de

Iowa Water Center | Iowa Water Center

Science.gov (United States)

Home Iowa State University Extension Iowa Water Center Submitted by mollyd on April 24, 2012 - 09 :42 Advancing the state of water knowledge and management The Iowa Water Center is a part of a nationwide network of university-based water centers created to encourage interdisciplinary water research

User-Centered Design through Learner-Centered Instruction

Science.gov (United States)

Altay, Burçak

2014-01-01

This article initially demonstrates the parallels between the learner-centered approach in education and the user-centered approach in design disciplines. Afterward, a course on human factors that applies learner-centered methods to teach user-centered design is introduced. The focus is on three tasks to identify the application of theoretical and…

The effects of light-induced reduction of the photosystem II reaction center

Czech Academy of Sciences Publication Activity Database

Kutý, Michal

2009-01-01

Roč. 8, č. 15 (2009), s. 923-933 ISSN 1610-2940 R&D Projects: GA MŠk(CZ) LC06010 Institutional research plan: CEZ:AV0Z60870520 Keywords : Photosystem II * Reaction center * Pheophytin Subject RIV: CE - Biochemistry Impact factor: 2.336, year: 2009

Liquid viscosity of low-GWP refrigerant mixtures (R32 + R1234yf) and (R125 + R1234yf)

International Nuclear Information System (INIS)

Dang, Yagu; Kamiaka, Takumi; Dang, Chaobin; Hihara, Eiji

2015-01-01

Highlights: • We measured liquid viscosity of low GWP refrigerant R1234yf binary mixtures. • Viscosity of R1234yf mixtures were correlated with the roughness hard-sphere method. • Viscosity of R1234yf mixtures were correlated with the Grunberg and Nissan method. - Abstract: In this work, the viscosity of R1234yf, (R32 + R1234yf), and (R125 + R1234yf) in one-phase liquid was measured. The combined expanded uncertainty of viscosity measurement apparatus of confidence of 0.95 (k = 2) is about 2.0%. The measurements of mixtures containing (30.0, 50.0, and 70.0) wt% R32 or R125 were carried out between T = (283.0 and 323.0) K (at intervals of T = 5 K) and P = (1.58 and 2.74) MPa, with a moving piston viscometer (VISCOpro 1600, accuracy ±1.0%) and a Coriolis flowmeter (Ultramass MKII, accuracy ±0.001 g/ml). The measured data were correlated with a hard-sphere (RSH) method and the Grunberg and Nissan method. The average absolute deviations are (2.2 and 3.3)% for the (R32 + R1234yf) and (R125 + R1234yf) mixtures by RSH method, (2.8 and 1.3)% for the (R32 + R1234yf) and (R125 + R1234yf) mixtures by Grunberg and Nissan method, while (3.5 and 2.4)% for the (R32 + R1234yf) and (R125 + R1234yf) mixtures by RefProp V9.1, respectively

Recombination luminescence from H centers and conversion of H centers into I centers in alkali iodides

International Nuclear Information System (INIS)

Berzina, B.J.

1981-01-01

The study is aimed at the search for H-plus-electron centers of luminescence and the investigation of the conversion of H- into I centers by the luminescence of H-plus-electron centers in alkali iodide crystals. KI, RbI and NaI crystals were studied at 12 K. H and F centers were created by irradiation with ultraviolet light corresponding to the absorption band of anion excitons. Then the excitation of electron centers by red light irradiation was followed. The spectra of stimulated recombination luminescence were studied. The luminescence of H-plus- electron centers had been observed and the conclusion was made that this center was formed on immobile H centers. In case of stable H centers the optically stimulated conversion of H centers into I centers occurs. The assumption is advanced on the spontaneous annihilation of near placed unstable F, H centers which leads to the creation of H-plus-electron luminescence centers and to the spontaneous H-I-centers conversion [ru

A new method for solving the two-center problem with relativistic potentials

International Nuclear Information System (INIS)

Gareev, F.A.; Gizzatkulov, M.Ch.

1977-01-01

A method has been proposed for the solution of the two-center problem with realistic potentials. It consists of two steps: first, a separable approximation to the single particle potentials is made and then the two-center problem with these separable potentials is solved exactly. The only approximations are introduced at the first stage in a well controllable way. As an example, we have calculated the single-particle energies and wave functions in the field of two 16 O like the Woods-Saxon potentials as functions of their distance R

78 FR 107 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2013-01-02

... Biochemistry of Membranes. Date: January 23, 2013. Time: 1:00 p.m. to 1:30 p.m. Agenda: To review and evaluate... 20036. Contact Person: Nitsa Rosenzweig, Ph.D., Scientific Review Officer, Center for Scientific Review... Santa Monica Hotel, 530 West Pico Boulevard, Santa Monica, CA 90405. Contact Person: David R. Jollie, Ph...

77 FR 77080 - Center for Scientific Review; Notice of Closed Meetings

Science.gov (United States)

2012-12-31

... Biochemistry of Membranes. Date: January 23, 2013. Time: 1:00 p.m. to 1:30 p.m. Agenda: To review and evaluate... 20036. Contact Person: Nitsa Rosenzweig, Ph.D., Scientific Review Officer, Center for Scientific Review... Santa Monica Hotel, 530 West Pico Boulevard, Santa Monica, CA 90405. Contact Person: David R. Jollie, Ph...

Quality control of pediatric chest X-rays in diagnostic centers with and without pediatric competence

International Nuclear Information System (INIS)

Alt, C.D.; Engelmann, D.; Schenk, J.P.; Troeger, J.

2006-01-01

Purpose: Radiation protection in pediatric radiology is very important because of the particular sensitivity of radiosensitive organs in younger patients. Optimized image quality supports radiation protection and should be targeted. In our study we examined the quality of pediatric chest X-rays at diagnostic centers (university hospitals and other large clinics). We then evaluated differences in image quality in departments without pediatric competence (R) and departments with pediatric competence (PR). Materials and Methods: Our study was based on 313 conventional chest X-rays from 207 patients (192 p.a./a.p. and 121 lateral, 43 from R, 258 from PR and 12 neither from R nor KR) and 38 digital chest X-rays from 26 patients (25 p.a./a.p. and 13 lateral, 1 from R and 37 from PR). All patients (age 0 - 18 years) are from Nephroblastoma-Study SIOP-93/01-GPOH. We examined all initial chest X-rays, which were sent to us for evaluation upon request between 4/3/2002 and 6/14/2002. The examined parameters were: exposure, centering of the X-rays/patient positioning, collimation and sharpness. The X-rays were evaluated on a scale from 1 (best result) to 5 (worst result), resulting in an overall score of A = optimum, B = minor problems, C = major problems, or D = unusable. The optical density, the center of the image and the relative field size were also measured. Statistical tests (Mann-Whitney-U and log regression) were carried out on the conventional images. The study was performed retrospectively. The exposure, sharpness and optical density of the digital X-rays were not analyzed. Results: In the case of all conventional X-rays, the quality of the centering of the X-rays/patient positioning and collimation was moderate (average scale value: 2.4 and 2.8), and the quality of the exposure and sharpness was good and very good (average scale value: 1.9 and 1.5). The quality of the chest X-rays in departments with additional pediatric radiological expertise was better mainly in

Crystal structures of the transcriptional repressor RolR reveals a novel recognition mechanism between inducer and regulator.

Directory of Open Access Journals (Sweden)

De-Feng Li

Full Text Available Many members of the TetR family control the transcription of genes involved in multidrug resistance and pathogenicity. RolR (ResorcinolRegulator, the recently reported TetR-type regulator for aromatic catabolism from Corynebacterium glutamicum, distinguishes itself by low sequence similarities and different regulation from the previously known members of the TetR family. Here we report the crystal structures of RolR in its effector-bound (with resorcinol and aop- forms at 2.5 Å and 3.6 Å, respectively. The structure of resorcinol-RolR complex reveal that the hydrogen-bonded network mediated by the four-residue motif (Asp94- Arg145- Arg148- Asp149 with two water molecules and the hydrophobic interaction via five residues (Phe107, Leu111, Leu114, Leu142, and Phe172 are the key factors for the recognition and binding between the resorcinol and RolR molecules. The center-to-center separation of the recognition helices h3-h3' is decreased upon effector-binding from 34.9 Å to 30.4 Å. This structural change results in that RolR was unsuitable for DNA binding. Those observations are distinct from that in other TetR members. Structure-based mutagenesis on RolR was carried out and the results confirmed the critical roles of the above mentioned residues for effector-binding specificity and affinity. Similar sequence searches and sequence alignments identified 29 RolR homologues from GenBank, and all the above mentioned residues are highly conserved in the homologues. Based on these structural and other functional investigations, it is proposed that RolR may represent a new subfamily of TetR proteins that are invovled in aromatic degradation and sharing common recognition mode as for RolR.

The accident of stereotaxic radiosurgery at the University hospital center of Toulouse. Expert report n.2. Dosimetric and clinical evaluation. Risk analysis

International Nuclear Information System (INIS)

2008-01-01

The regional center of stereotaxic radiosurgery (C.R.R.S.) of the University hospital center (C.H.U.) of Toulouse is equipped since april 2006 with a Novalis accelerator (Brainlab) devoted to radiosurgery and intra skull stereotaxic radiotherapy.In april 2007, during an intercomparison of dosimetry files coming from various sites, the Brainlab society detects an anomaly. The analysis made by the society concludes to the use of an unsuited detector for the measurement of a dosimetry parameter during the accelerator initial calibration. Following this error, 145 patients (on 172 patients treated since the center opening) suffer of an overdose whom importance is variable. On the 26. june 2007 the Authority of nuclear safety (Asn) requires an expertise on the following points: checking of the experimental protocols of micro-beams calibration before and after correction of the dysfunction; analysis at the theoretical level of the neurological complications risk at long term for the exposed patients. The second point of this request is the subject of this report. It gives the synthesis of the whole of information, at the clinical and dosimetric level and outlines successively: the expertise methodology; the cohort of patients treated at the C.R.R.S.; the parameters of the risk analysis of neurological complications; the different risk analysis according the pathologies treated at the C.R.R.S.; the recommendations. (N.C.)

76 FR 10913 - National Center for Complementary & Alternative Medicine; Notice of Closed Meeting

Science.gov (United States)

2011-02-28

... Complementary & Alternative Medicine; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... Alternative Medicine Special Emphasis Panel, Mechanistic Research on CAM Natural Products (R01). Date: March..., Scientific Review Officer, Office of Scientific Review, National Center for Complementary & Alternative...

Attraction et rétention des centres d’appels : l’innovation socioterritoriale comme source d’avantages concurrentiels?

Directory of Open Access Journals (Sweden)

Diane-Gabrielle Tremblay

2011-11-01

Full Text Available Dans un contexte de mondialisation de l’économie, les territoires sont dans une situation de compétition mondiale pour attirer et retenir des entreprises, telles que les centres d’appels, qui bénéficient du développement et de la densification des réseaux de télécommunication à l’échelle mondiale.Les centres d’appels sont souvent perçus comme ayant à une forte propension à se délocaliser dans les régions qui présentent les coûts de main-d'œuvre les plus faibles. Certains gouvernements perçoivent qu’il est vain d’investir des efforts importants pour favoriser leur attraction, car les centres d’appels disparaissent ou s’en vont dans d’autres régions par la suite. D’autres, cependant, continuent de penser que leur territoire est propice à l’implantation de centres d’appels, mettant en avant des caractéristiques socio-économiques et géographiques qui leur donnent un avantage compétitif face à d’autres régions, et ils considèrent les centres d’appels comme un outil de développement économique intéressant, notamment pour compenser les pertes d’emplois liés à la désindustrialisation. Animés par la volonté d’en savoir davantage sur ce phénomène et de comprendre les raisons qui amènent les centres d’appels à choisir une région d’implantation plutôt qu’une autre et celles qui les incitent à rester ou à partir, nous sommes allés à la rencontre d’agences de développement économique et de centres d’appels au Québec et au Canada (Montréal et la région Ottawa/Outaouais. À partir d’entretiens qualitatifs que nous avons recoupés avec la recension des écrits sur les centres d’appels, nous identifions des facteurs d’attraction et de rétention des centres d’appels sur les territoires, dont le Québec.Nous concluons que c’est par l’innovation que les institutions peuvent parvenir à développer des avantages concurrentiels durables : par un développement de

The Water Recovery X-ray Rocket (WRX-R)

Science.gov (United States)

Miles, Drew

2017-08-01

The Water Recovery X-ray Rocket (WRX-R) is a diffuse soft X-ray spectrometer that will launch on a sounding rocket from the Kwajalein Atoll. WRX-R has a field of view of >10 deg2 and will observe the Vela supernova remnant. A mechanical collimator, state-of-the-art off-plane reflection grating array and hybrid CMOS detector will allow WRX to achieve the most highly-resolved spectrum of the Vela SNR ever recorded. In addition, this payload will fly a hard X-ray telescope that is offset from the soft X-ray spectrometer in order to observe the pulsar at the center of the remnant. We present here an introduction to the instrument, the expected science return, and an update on the state of the payload as we work towards launch.

ON THE r -PROCESS ENRICHMENT OF DWARF SPHEROIDAL GALAXIES

Energy Technology Data Exchange (ETDEWEB)

Bramante, Joseph [Department of Physics, 225 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556 (United States); Linden, Tim [Center for Cosmology and AstroParticle Physics (CCAPP) and Department of Physics The Ohio State University, Columbus OH, 43210 (United States)

2016-07-20

Recent observations of Reticulum II have uncovered an overabundance of r -process elements compared to similar ultra-faint dwarf spheroidal galaxies (UFDs). Because the metallicity and star formation history of Reticulum II appear consistent with all known UFDs, the high r -process abundance of Reticulum II suggests enrichment through a single, rare event, such as a double neutron star (NS) merger. However, we note that this scenario is extremely unlikely, as binary stellar evolution models require significant supernova natal kicks to produce NS–NS or NS–black hole (BH) mergers, and these kicks would efficiently remove compact binary systems from the weak gravitational potentials of UFDs. We examine alternative mechanisms for the production of r -process elements in UFDs, including a novel mechanism wherein NSs in regions of high dark matter (DM) density implode after accumulating a BH-forming mass of DM. We find that r -process proto-material ejection by tidal forces, when a single NS implodes into a BH, can occur at a rate matching the r -process abundance of both Reticulum II and the Milky Way. Remarkably, DM models which collapse a single NS in observed UFDs also solve the missing pulsar problem in the Milky Way Galactic Center. We propose tests specific to DM r -process production which may uncover or rule out this model.

Magnetization processes in amorphous R-Co/R'-Co/R-Co sandwiches (R, R'=Y, Nd, Gd, Er)

International Nuclear Information System (INIS)

Dieny, B.; Givord, D.; Ndjaka, J.M.B.; Alameda, J.M.

1990-01-01

Sandwiches consisting of three amorphous layers (R 0.33 ,Co 0.67 )( 1000 A / R ' 0.33 ,Co 0.67 ) 1000 A / (R 0.33 Co 0.67 ) 1000 A , have been prepared by dc triode sputtering (R, R' are rare-earth elements). The systems chosen are such that the bulk magnetization alternates from one layer to the next or the coercivity of each layer is significantly different. Magnetic transitions are observed under field. They have been quantitatively analyzed in terms of successive reversals of magnetization in the different layers. The creation or annihilation of planar Bloch walls parallel to the surface are associated with the magnetic transitions. The wall energy and wall width depend essentially on the competition between exchange energy and Zeeman energy. It is suggested that the existence of such Bloch walls may favor magnetization reversal in thin films by coherent processes

Pulse-electron paramagnetic resonance of Cr.sup.3+./sup. centers in SrTiO.sub.3./sub..

Czech Academy of Sciences Publication Activity Database

Azamat, Dmitry; Dejneka, Alexandr; Lančok, Ján; Trepakov, Vladimír; Jastrabík, Lubomír; Badalyan, A. G.

2013-01-01

Roč. 113, č. 17 (2013), "174106-1"-"174106-6" ISSN 0021-8979 R&D Projects: GA MŠk(CZ) LM2011029; GA TA ČR TA01010517; GA ČR GAP108/12/1941 Grant - others:SAFMAT(XE) CZ.2.16/3.1.00/22132 Institutional support: RVO:68378271 Keywords : pulse-electron paramagnetic resonance * Cr3+ centers in SrTiO 3 Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.185, year: 2013

Når det er svært at være ung i DK

DEFF Research Database (Denmark)

Nielsen, Jens Christian; Sørensen, Niels Ulrik

Når det er svært at være ung i DK – viden og råd om unges trivsel og mistrivsel er afslutningen på et større forskningsprojekt om unges trivsel og mistrivsel. Hæftet præsenterer forskningsprojektets hovedkonklusioner og giver desuden en række råd og ideer til, hvordan voksne kan hjælpe unge med...... at håndtere mistrivsel. Hæftet er udarbejdet af forskerne Jens Christian Nielsen og Niels Ulrik Sørensen fra Center for Ungdomsforskning. Det er den sidste publikation i forskningsprojektet Når det er svært at være ung i DK, der fra 2008-2011 har belyst unges trivsel og mistrivsel. Projektet bygger både på en...

78 FR 50102 - Notice of Inventory Completion: Rochester Museum & Science Center, Rochester, NY

Science.gov (United States)

2013-08-16

.... 3003, of the completion of an inventory of associated funerary objects under the control of the....R50000] Notice of Inventory Completion: Rochester Museum & Science Center, Rochester, NY AGENCY: National... inventory of associated funerary objects, in consultation with the appropriate Indian tribes or Native...

Report for 2012 from the Bordeaux IVS Analysis Center

Science.gov (United States)

Charlot, Patrick; Bellanger, Antoine; Bouffet, Romuald; Bourda, Geraldine; Collioud, Arnaud; Baudry, Alain

2013-01-01

This report summarizes the activities of the Bordeaux IVS Analysis Center during the year 2012. The work focused on (i) regular analysis of the IVS-R1 and IVS-R4 sessions with the GINS software package; (ii) systematic VLBI imaging of the RDV sessions and calculation of the corresponding source structure index and compactness values; (iii) investigation of the correlation between astrometric position instabilities and source structure variations; and (iv) continuation of our VLBI observational program to identify optically-bright radio sources suitable for the link with the future Gaia frame. Also of importance is the 11th European VLBI Network Symposium, which we organized last October in Bordeaux and which drew much attention from the European and International VLBI communities.

On dynamical systems approaches and methods in f ( R ) cosmology

Energy Technology Data Exchange (ETDEWEB)

Alho, Artur [Center for Mathematical Analysis, Geometry and Dynamical Systems, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Carloni, Sante [Centro Multidisciplinar de Astrofisica – CENTRA, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa (Portugal); Uggla, Claes, E-mail: aalho@math.ist.utl.pt, E-mail: sante.carloni@tecnico.ulisboa.pt, E-mail: claes.uggla@kau.se [Department of Physics, Karlstad University, S-65188 Karlstad (Sweden)

2016-08-01

We discuss dynamical systems approaches and methods applied to flat Robertson-Walker models in f ( R )-gravity. We argue that a complete description of the solution space of a model requires a global state space analysis that motivates globally covering state space adapted variables. This is shown explicitly by an illustrative example, f ( R ) = R + α R {sup 2}, α > 0, for which we introduce new regular dynamical systems on global compactly extended state spaces for the Jordan and Einstein frames. This example also allows us to illustrate several local and global dynamical systems techniques involving, e.g., blow ups of nilpotent fixed points, center manifold analysis, averaging, and use of monotone functions. As a result of applying dynamical systems methods to globally state space adapted dynamical systems formulations, we obtain pictures of the entire solution spaces in both the Jordan and the Einstein frames. This shows, e.g., that due to the domain of the conformal transformation between the Jordan and Einstein frames, not all the solutions in the Jordan frame are completely contained in the Einstein frame. We also make comparisons with previous dynamical systems approaches to f ( R ) cosmology and discuss their advantages and disadvantages.

Recognition determinants for proteins and antibiotics within 23S rRNA

DEFF Research Database (Denmark)

Douthwaite, Stephen Roger; Voldborg, Bjørn Gunnar Rude; Hansen, Lykke Haastrup

1995-01-01

Ribosomal RNAs fold into phylogenetically conserved secondary and tertiary structures that determine their function in protein synthesis. We have investigated Escherichia coli 23S rRNA to identify structural elements that interact with antibiotic and protein ligands. Using a combination of molecu......Ribosomal RNAs fold into phylogenetically conserved secondary and tertiary structures that determine their function in protein synthesis. We have investigated Escherichia coli 23S rRNA to identify structural elements that interact with antibiotic and protein ligands. Using a combination......-proteins L10.(L12)4 and L11 and is inhibited by interaction with the antibiotic thiostrepton. The peptidyltransferase center within domain V is inhibited by macrolide, lincosamide, and streptogramin B antibiotics, which interact with the rRNA around nucleotide A2058. Drug resistance is conferred by mutations...

An efficient conversion of (3R,3'R,6'R)-lutein to (3R,3'S,6'R)-lutein (3'-epilutein) and (3R,3'R)-zeaxanthin.

Science.gov (United States)

Khachik, Frederick

2003-01-01

Two dietary carotenoids, (3R,3'R,6'R)-lutein (1) and (3R,3'R)-zeaxanthin (2), and their metabolite (3R,3'S,6'R)-lutein (3'-epilutein) (3) accumulate in human serum, milk, and ocular tissues. There is increasing evidence that compounds 1 and 2 play an important role in the prevention of age-related macular degeneration. Therefore, the availability of these carotenoids for metabolic studies and clinical trials is essential. Compound 1 is isolated from extracts of marigold flowers (Tagete erecta) and is commercially available, whereas 2 is only accessible by a lengthy total synthesis, and a viable method for synthesis of 3 has not yet been developed. This report describes an efficient conversion of technical grade 1 to 2 via 3. Acid-catalyzed epimerization of 1 yields an equimolar mixture of diastereomers 1 and 3. The mixture was separated by enzyme-mediated acylation with lipase AK from Pseudomonas fluorescens that preferentially esterified 3 and after alkaline hydrolysis yielded this carotenoid in 90% diastereomeric excess (de). Compound 3 was also separated from 1 in 56-88% de by solvent extraction and low-temperature crystallization, Soxhlet extraction, or supercritical fluid extraction. Base-catalyzed isomerization of 3 gave 2 in excellent yield, providing a convenient alternative to the total synthesis of this important dietary carotenoid.

Birth Satisfaction Scale/Birth Satisfaction Scale-Revised (BSS/BSS-R): A large scale United States planned home birth and birth centre survey

OpenAIRE

Fleming, Susan E.; Donovan-Batson, Colleen.; Burduli, Ekaterina.; Barbosa-Leiker, Celestina.; Hollins Martin, Caroline J.; Martin, Colin R.

2016-01-01

Objective:\\ud to explore the prevalence of birth satisfaction for childbearing women planning to birth in their home or birth centers in the United States. Examining differences in birth satisfaction of the home and birth centers; and those who birthed in a hospital using the 30-item Birth Satisfaction Scale (BSS) and the 10-item Birth Satisfaction Scale-Revised (BSS-R).\\ud Study design:\\ud a quantitative survey using the BSS and BSS-R were employed. Additional demographic data were collected...

Altered gravity influences rDNA and NopA100 localization in nucleoli

Science.gov (United States)

Sobol, M. A.; Kordyum, E. L.

Fundamental discovery of gravisensitivity of cells no specified to gravity perception focused increasing attention on an elucidation of the mechanisms involved in altered gravity effects at the cellular and subcellular levels. The nucleolus is the transcription site of rRNA genes as well as the site of processing and initial packaging of their transcripts with ribosomal and nonribosomal proteins. The mechanisms inducing the changes in the subcomponents of the nucleolus that is morphologically defined yet highly dynamic structure are still unknown in detail. To understand the functional organization of the nucleolus as in the control as under altered gravity conditions it is essential to determine both the precise location of rDNA and the proteins playing the key role in rRNA processing. Lepidium sativum seeds were germinated in 1% agar medium on the slow horizontal clinostat (2 rpm) and in the stationary conditions. We investigated the root meristematic cells dissected from the seedlings grown in darkness for two days. The investigations were carried out with anti-DNA and anti-NopA100 antibodies labeling as well as with TdT procedure, and immunogold electron microscopy. In the stationary growth conditions, the anti-DNA antibody as well TdT procedure were capable of detecting fibrillar centers (FCs) and the dense fibrillar component (DFC) in the nucleolus. In FCs, gold particles were revealed on the condensed chromatin inclusions, internal fibrils of decondensed rDNA and the transition zone FC-DFC. Quantitatively, FCs appeared 1,5 times more densely labeled than DFC. NopA100 was localized in FCs and in DFC. In FCs, the most of protein was revealed in the transition zone FC-DFC. After a quantitative study, FCs and the transition zone FC-DFC appeared to contain NopA100 1,7 times more than DFC. Under the conditions of altered gravity, quantitative data clearly showed a redistribution of nucleolar DNA and NopA100 between FCs and DFC in comparison with the control. In

miR-7 Buffers Differentiation in the Developing Drosophila Visual System

Directory of Open Access Journals (Sweden)

Elizabeth E. Caygill

2017-08-01

Full Text Available The 40,000 neurons of the medulla, the largest visual processing center of the Drosophila brain, derive from a sheet of neuroepithelial cells. During larval development, a wave of differentiation sweeps across the neuroepithelium, converting neuroepithelial cells into neuroblasts that sequentially express transcription factors specifying different neuronal cell fates. The switch from neuroepithelial cells to neuroblasts is controlled by a complex gene regulatory network and is marked by the expression of the proneural gene l’sc. We discovered that microRNA miR-7 is expressed at the transition between neuroepithelial cells and neuroblasts. We showed that miR-7 promotes neuroepithelial cell-to-neuroblast transition by targeting downstream Notch effectors to limit Notch signaling. miR-7 acts as a buffer to ensure that a precise and stereotypical pattern of transition is maintained, even under conditions of environmental stress, echoing the role that miR-7 plays in the eye imaginal disc. This common mechanism reflects the importance of robust visual system development.

Changing R&D models in research-based pharmaceutical companies.

Science.gov (United States)

Schuhmacher, Alexander; Gassmann, Oliver; Hinder, Markus

2016-04-27

New drugs serving unmet medical needs are one of the key value drivers of research-based pharmaceutical companies. The efficiency of research and development (R&D), defined as the successful approval and launch of new medicines (output) in the rate of the monetary investments required for R&D (input), has declined since decades. We aimed to identify, analyze and describe the factors that impact the R&D efficiency. Based on publicly available information, we reviewed the R&D models of major research-based pharmaceutical companies and analyzed the key challenges and success factors of a sustainable R&D output. We calculated that the R&D efficiencies of major research-based pharmaceutical companies were in the range of USD 3.2-32.3 billion (2006-2014). As these numbers challenge the model of an innovation-driven pharmaceutical industry, we analyzed the concepts that companies are following to increase their R&D efficiencies: (A) Activities to reduce portfolio and project risk, (B) activities to reduce R&D costs, and (C) activities to increase the innovation potential. While category A comprises measures such as portfolio management and licensing, measures grouped in category B are outsourcing and risk-sharing in late-stage development. Companies made diverse steps to increase their innovation potential and open innovation, exemplified by open source, innovation centers, or crowdsourcing, plays a key role in doing so. In conclusion, research-based pharmaceutical companies need to be aware of the key factors, which impact the rate of innovation, R&D cost and probability of success. Depending on their company strategy and their R&D set-up they can opt for one of the following open innovators: knowledge creator, knowledge integrator or knowledge leverager.

Enhanced extraction of silicon-vacancy centers light emission using bottom-up engineered polycrystalline diamond photonic crystal slabs

Czech Academy of Sciences Publication Activity Database

Ondič, Lukáš; Varga, Marián; Hruška, Karel; Fait, J.; Kapusta, Peter

2017-01-01

Roč. 11, č. 3 (2017), s. 2972-2981 ISSN 1936-0851 R&D Projects: GA ČR GJ16-09692Y; GA MŠk LD15003; GA ČR(CZ) GBP208/12/G016 Institutional support: RVO:68378271 ; RVO:61388955 Keywords : photonic crystal * diamond * silicon vacancy center Subject RIV: BM - Solid Matter Physics ; Magnetism; CF - Physical ; Theoretical Chemistry (UFCH-W) OBOR OECD: Condensed matter physics (including formerly solid state physics, supercond.); Physical chemistry (UFCH-W) Impact factor: 13.942, year: 2016

Exact Hausdorff centered measure of symmetry Cantor sets

Energy Technology Data Exchange (ETDEWEB)

Dai Meifeng [Department of Mathematics, Jiangsu University, Zhenjiang 212013 (China)] e-mail: daimf0225@163.com; Tian Lixin [Department of Mathematics, Jiangsu University, Zhenjiang 212013 (China)] e-mail: tianlx@ujs.edu.cn

2005-10-01

Let K({lambda}{sub 1},{lambda}{sub 2}), the symmetry Cantor sets, be the attractor of an iterated function system {l_brace}f{sub 1},f{sub 2},f{sub 3}{r_brace} on the line, where f{sub 1}(x)={lambda}{sub 1}x, f{sub 2}(x)={lambda}{sub 2}x+1-{lambda}{sub 2}2,f{sub 3}(x)=1-{lambda}{sub 1}+{lambda}{sub 1}x, x-bar [0,1]. In this paper, we proved that if 1-2{lambda}{sub 1}-{lambda}{sub 2}2>={lambda}, where {lambda}=max{l_brace}{lambda}{sub 1},{lambda}{sub 2}{r_brace}, then the exact Hausdorff centered measure C{sup s} of K({lambda}{sub 1},{lambda}{sub 2}) equals 1, where s is the Hausdorff dimension of K({lambda}{sub 1},{lambda}{sub 2})

ACToR Chemical Structure processing using Open Source ChemInformatics Libraries (FutureToxII)

Science.gov (United States)

ACToR (Aggregated Computational Toxicology Resource) is a centralized database repository developed by the National Center for Computational Toxicology (NCCT) at the U.S. Environmental Protection Agency (EPA). Free and open source tools were used to compile toxicity data from ove...

Financing of certified centers: a willingness-to-pay analysis.

Science.gov (United States)

Thiel, Falk C; Scharl, Anton; Hildebrandt, Thomas; Kotziabassis, Efstratios; Schrauder, Michael G; Bani, Mayada R; Müller, Andreas; Hauzenberger, Tanja; Loehberg, Christian R; Jud, Sebastian M; Fasching, Peter A; Hartmann, Arndt; Schulz-Wendtland, Rüdiger; Strnad, Vratislav; Beckmann, Matthias W; Lux, Michael Patrick

2013-03-01

Although care in certified breast centers is now established throughout Germany, numerous services are still not being reimbursed. This also affects other centers involved in the specialty of gynecology such as gynecological cancer centers, perinatal centers, and endometriosis centers. Although a certified center is entitled to charge additional fees, these are in most cases not reimbursed. Calculation of additional costs is limited by the fact that data from the Institute for the Hospital Reimbursement System (Institut für das Entgeltsystem im Krankenhaus, InEK) do not reflect interdisciplinary services and procedures. For decision-makers, society's willingness to pay is an important factor in guiding decisions on the basis of social priorities. A hypothetical maximum willingness to pay can be calculated using a willingness-to-pay analysis, making it possible to identify deficiencies in the arbitrary setting of health budgets at the macro-level. In a multicenter study conducted between November 2009 and December 2010, 2,469 patients at a university hospital and at a non-university hospital were asked about the extent of their awareness of certified centers, the influence of centers on hospital presentation, and about personal attitudes toward quality-oriented reimbursement. A subjective assessment of possible additional charges was calculated using a willingness-to-pay analysis. In the overall group, 53.4 % of the patients were aware of what a certified center is and 27.4 % had specific information (obstetrics 40.0/32.3 %; mastology 66.8/23.2 %; gynecological oncology 54.7/27.3 %; P < 0.001). For 43.8 %, a certified center was one reason or the major reason for presentation (obstetrics 26.2 %; mastology 66.8 %; gynecological oncology 46.6 %; P < 0.001). A total of 72.6 % were in favor of quality-oriented reimbursement and 69.7 % were in favor of an additional charge for a certified center amounting to €538.56 (mastology €643.65, obstetrics €474

Factor VII deficiency: a single-center experience.

Science.gov (United States)

Salcioglu, Zafer; Akcay, Arzu; Sen, Hulya Sayilan; Aydogan, Gonul; Akici, Ferhan; Tugcu, Deniz; Ayaz, Nuray Aktay; Baslar, Zafer

2012-11-01

Congenital factor VII deficiency is the most common form of rare coagulation factor deficiencies. This article presents a retrospective evaluation of 73 factor VII deficiency cases that had been followed at our center. The study consisted of 48 males and 25 females (2 months-19 years). Thirty-one (42.5%) of them were asymptomatic. Out of symptomatic patients, 17 had severe clinical symptoms, whereas 8 presented with moderate and 17 with mild symptoms. The symptoms listed in order of frequency were as follows: epistaxis, petechia or ecchymose, easy bruising, and oral cavity bleeding. The genotype was determined in 8 patients. Recombinant activated factor VII (rFVIIa) was used to treat 49 bleeding episodes in 8 patients after 2002. In 2 patients with repeated central nervous system bleeding prophylaxis with rFVIIa was administered. No allergic and thrombotic events were observed during both treatment and prophylaxis courses. Antibody occurrence was not detected in the patients during treatment.

The C.L.E.A.R. Score: a new comprehensive assessment method for academic physicians in military medical centers.

Science.gov (United States)

Buller, Jerome L; Tetteh, Hassan A

2012-07-01

Evaluation of medical officer performance is a critical leadership role. This study offers a comprehensive evaluation system for military physicians. The Comprehensive Assessment equation (COMPASS equation), a modified Cobb-Douglas equation, was developed to evaluate academic physicians. The COMPASS equation assesses military physicians within five comprehensive dimensions: (1) Clinical (2) Leadership, (3) Educational (4) Administrative, and (5) Research productivity excellence to yield a composite "C.L.E.A.R. Score." The COMPASS equation's fidelity was tested with a cohort of military physicians within the department of Obstetrics and Gynecology in the Capital District Region and a C.L.E.A.R. score was calculated for individual physicians. Mean C.L.E.A.R score was 53.6 +/- 28.8 (range 10.1-98.5). The responsiveness of the model was tested using two hypothetical physician models: "low-performing-faculty" and "super-faculty," and calculated C.L.E.A.R. scores were 6.3 and 153.4, respectively. The C.L.E.A.R. score appears to recognize and assess the performance excellence of military physicians. Weighting measured characteristics of the COMPASS equation can be used to promote organizational priorities. Thus, leaders of military medicine can communicate institutional priorities and inculcate them through use of the COMPASS equation to reward and recognize the activities of military medical officers that are commensurate with institutional goals.

Pulse Radiolysis Studies of Temperature Dependent Electron Transfers among Redox Centers in ba(3)-Cytochrome c Oxidase from Thermus thermophilus

DEFF Research Database (Denmark)

Farver, Ole; Wherland, Scot; Antholine, William E

2010-01-01

The functioning of cytochrome c oxidases involves orchestration of long-range electron transfer (ET) events among the four redox active metal centers. We report the temperature dependence of electron transfer from the Cu(A)(r) site to the low-spin heme-(a)b(o) site, i.e., Cu(A)(r) + heme-a(b)(o) ......The functioning of cytochrome c oxidases involves orchestration of long-range electron transfer (ET) events among the four redox active metal centers. We report the temperature dependence of electron transfer from the Cu(A)(r) site to the low-spin heme-(a)b(o) site, i.e., Cu(A)(r) + heme...... in cytochrome ba(3) had no effect on the rate of this reaction whereas the II-Met160Leu Cu(A)-mutation was slower by an amount corresponding to a decreased driving force of ∼0.06 eV. The structures support the presence of a common, electron-conducting "wire" between Cu(A) and heme-a(b). The transfer...

Monitoring the Dusty S-cluster Object (DSO/G2) on its Orbit toward the Galactic Center Black Hole

Czech Academy of Sciences Publication Activity Database

Valencia-S, M.; Eckart, A.; Zajaček, Michal; Peissker, F.; Parsa, M.; Grosso, N.; Mossoux, E.; Porquet, D.; Jalali, B.; Karas, Vladimír; Yazici, S.; Shahzamanian, B.; Sabha, N.; Saalfeld, R.; Smajic, S.; Grellmann, R.; Moser, L.; Horrobin, M.; Borkar, A.; García-Marín, M.; Dovčiak, Michal; Kunneriath, Devaky; Karssen, G.; Bursa, Michal; Straubmeier, C.; Bushouse, H.

2015-01-01

Roč. 800, č. 2 (2015), 125/1-125/21 ISSN 0004-637X R&D Projects: GA ČR(CZ) GC13-00070J Grant - others:EU(XE) COST Action MP0905 Institutional support: RVO:67985815 Keywords : black holes * galactic center * Milky way Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics Impact factor: 5.909, year: 2015

75 FR 14069 - Amendment of Using Agency for Restricted Areas R-3005A, R-3305B, R-3005C, R-3005D and R-3005E...

Science.gov (United States)

2010-03-24

...; Airspace Docket No. 10-ASO-19] RIN 2120-AA66 Amendment of Using Agency for Restricted Areas R-3005A, R-3305B, R-3005C, R-3005D and R-3005E; Fort Stewart, GA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action changes the using agency of restricted areas R- 3005A, R-3005B...

Pharmacokinetics and metabolism of (R,R)-methoxyfenoterol in rat.

Science.gov (United States)

Siluk, D; Mager, D E; Kim, H S; Wang, Y; Furimsky, A M; Ta, A; Iyer, L V; Green, C E; Wainer, I W

2010-03-01

(R,R)-fenoterol (Fen), a beta(2)-adrenoceptor agonist, is under clinical investigation in the treatment of congestive heart disease. The pharmacokinetics and metabolism of the 4-methoxyphenyl derivative of (R,R)-Fen, (R,R)-MFen, have been determined following intravenous and oral administration to the rat and compared with corresponding results obtained with (R,R)-Fen. Results from the study suggest that (R,R)-MFen can offer pharmacokinetic and metabolic advantages in comparison to an earlier (R,R)-Fen. The oral administration revealed that the net exposure of (R,R)-MFen was about three-fold higher than that of (R,R)-Fen (7.2 versus 2.3 min x nmol ml(-1)), while intravenous administration proved that the clearance was significantly reduced, 48 versus 146 ml min(-1) kg(-1), the T(1/2) was significantly longer, 152.9 versus 108.9 min, and the area under the curve (AUC) was significantly increased, 300 versus 119 min x nmol ml(-1). (R,R)-MFen was primarily cleared by glucuronidation associated with significant presystemic glucuronidation of the compound. After intravenous and oral administration of (R,R)-MFen, (R,R)-Fen and (R,R)-Fen-G were detected in the urine samples indicating that (R,R)-MFen was O-demethylated and subsequently conjugated to (R,R)-Fen-G. The total (R,R)-Fen and (R,R)-Fen-G as a percentage of the dose after intravenous administration was 3.6%, while after oral administration was 0.3%, indicating that only a small fraction of the drug escaped presystemic glucuronidation and was available for O-demethylation. The glucuronidation pattern was confirmed by the results from in vitro studies where incubation of (R,R)-MFen with rat hepatocytes produced (R,R)-MFen-G, (R,R)-Fen and (R,R)-Fen-G, while incubation with rat intestinal microsomes only resulted in the formation of (R,R)-MFen-G.

New Mexico center for particle physics: Studies of fundmental interactions

International Nuclear Information System (INIS)

1997-01-01

This report summarizes the results of the research program in the New Mexico Center during the last year and presents our program of proposed research for the next year. The majority of the New Mexico Center group's research involves the CDF experiment at the Tevatron pp collider at Fermilab. Our group is a leader in all of the SVX vertex detector upgrades for CDF. These vertex detectors are of critical importance to the pursuit of our physics interests at the Tevatron; they are also an imposing instrumentation challenge. Our group is also deeply involved in several CDF B-physics analyses and in an exotics search. Our research also includes important contributions to R ampersand D for the ATLAS experiment at the LHC

Queueing System with Heterogeneous Customers as a Model of a Call Center with a Call-Back for Lost Customers

OpenAIRE

Dudin, Sergey; Kim, Chesoong; Dudina, Olga; Baek, Janghyun

2013-01-01

A multiserver queueing system with infinite and finite buffers, two types of customers, and two types of servers as a model of a call center with a call-back for lost customers is investigated. Type 1 customers arrive to the system according to a Markovian arrival process. All rejected type 1 customers become type 2 customers. Type r, r=1,2, servers serve type r customers if there are any in the system and serve type r′, r′=1,2,  r′≠r, customers if there are no type r customers in the system....

Parental stress response to sexual abuse and ritualistic abuse of children in day-care centers.

Science.gov (United States)

Kelley, S J

1990-01-01

The purpose of this study was to examine the stress responses of parents to the sexual and ritualistic abuse of their children in day-care centers. Sixty-five mothers and 46 fathers of children sexually abused in day-care centers completed the Symptom Checklist-90-Revised (SCL-90-R), a measure of psychological distress. These scores were compared with a carefully matched comparison group of parents of 67 nonabused children. Parents of abused children also completed the Impact of Event Scale (IES), a measure which indexes symptoms that characterize posttraumatic stress disorder. Parents of sexually abused children reported significantly more psychological distress than parents of nonabused children, with parents of ritually abused children displaying the most severe psychological distress. Parents of abused children reported symptom profiles on the SCL-90-R and IES consistent with posttraumatic stress disorder.

R and D on seismic emergency information system

International Nuclear Information System (INIS)

2001-06-01

After the Great Hansin-Awaji Earthquake Disaster occurred in 1995, the Science and Technology Agency commenced 'Frontier Research Program on Earthquake' in FY1996. As a part of this research program, four-year program on 'Research on Real-time Earthquake Information Transmission' has been carried out at JAERI since FY1997. Through the experience of the above earthquake disaster, the importance of accurate and prompt seismic information transmission immediately after the occurrence of the earthquake has been recognized from the viewpoint of disaster mitigation. Under this circumstance, the main activity in Real-time Earthquake Information Transmission Research at JAERI has been placed on the development of a seismic emergency information system. In order to respond to the above R and D, Seismic Emergency Information System Research Team was organized in JAERI in FY1998. In the meantime, a part of this R and D program is performed under the coordinated research between JAERI and NIED (National Research Institute for Earth Science and Disaster Prevention). This report summarizes the results of four years program from FY1997 to FY2000 on the above R and D. The R and D has been conducted involving the latest progress in earthquake engineering with regard to estimation techniques on the hypocenter, fault and earthquake motion parameters and in Information Technologies. The R and D was divided into two parts, i.e., development of the basic system and application system. In the basic system, earthquake information with 500 m square mesh in a local area can be estimated and transmitted in a few minutes. In the application system, the concept of the disaster management system which consists of user site and disaster information center and is capable of mutual information transmission has been established. A prototype of the application system, which include the basic system in the disaster information center, has been developed. Test operation of the basic system in being

Report for 2011 from the Bordeaux IVS Analysis Center

Science.gov (United States)

Charlot, Patrick; Bellanger, Antoine; Bourda, Geraldine; Collioud, Arnaud; Baudry, Alain

2012-01-01

This report summarizes the activities of the Bordeaux IVS Analysis Center during the year 2011. The work focused on (i) regular analysis of the IVS-R1 and IVS-R4 sessions with the GINS software package; (ii) systematic VLBI imaging of the RDV sessions and calculation of the corresponding source structure index and compactness values; (iii) imaging of the sources observed during the 2009 International Year of Astronomy IVS observing session; and (iv) continuation of our VLBI observational program to identify optically-bright radio sources suitable for the link with the future Gaia frame. Also of importance is the enhancement of the IVS LiveWeb site which now comprises all IVS sessions back to 2003, allowing one to search past observations for session-specific information (e.g. sources or stations).

Spanish validation of the Person-centered Care Assessment Tool (P-CAT).

Science.gov (United States)

Martínez, Teresa; Suárez-Álvarez, Javier; Yanguas, Javier; Muñiz, José

2016-01-01

Person-centered Care (PCC) is an innovative approach which seeks to improve the quality of care services given to the care-dependent elderly. At present there are no Spanish language instruments for the evaluation of PCC delivered by elderly care services. The aim of this work is the adaptation and validation of the Person-centered Care Assessment Tool (P-CAT) for a Spanish population. The P-CAT was translated and adapted into Spanish, then given to a sample of 1339 front-line care professionals from 56 residential elderly care homes. The reliability and validity of the P-CAT were analyzed, within the frameworks of Classical Test Theory and Item Response Theory models. The Spanish P-CAT demonstrated good reliability, with an alpha coefficient of .88 and a test-retest reliability coefficient of .79. The P-CAT information function indicates that the test measures with good precision for the majority of levels of the measured variables (θ values between -2 and +1). The factorial structure of the test is essentially one-dimensional and the item discrimination indices are high, with values between .26 and .61. In terms of predictive validity, the correlations which stand out are between the P-CAT and organizational climate (r = .689), and the burnout factors; personal accomplishment (r = .382), and emotional exhaustion (r = - .510). The Spanish version of the P-CAT demonstrates good psychometric properties for its use in the evaluation of elderly care homes both professionally and in research.

R-744 compared to R-290 in small freezer applications; R-744 versus R-290 in kleine vriezer-toepassingen

Energy Technology Data Exchange (ETDEWEB)

Van Beek, M.; Janssen, M. [Re/gent, Helmond (Netherlands)

2009-04-15

An experimental and analytical comparison between R-744 (CO2) and R-290 (propane) as refrigerant for small capacity freezer applications is described. A commercially available plug-in freezer cabinet for sales of frozen foods or ice cream, fitted with an R-290 (8,1 cm{sup 3}) hermetic compressor, was retrofitted to R-744 using standard components and a state of the art R-744 compressor. The results of energy consumption and storage temperature testing on both systems are presented as well as a discussion on the system modifications required for using R-744. Both refrigerant loops are analyzed and the deviations with the thermodynamically ideal loops are discussed. The analysis is further supported by calorimetric tests of the R-744 compressor at low evaporation temperatures. Theoretical comparison of the ideal loops, using performance data from the compressors used in the experiments, shows that the R-744 circuit is 31% less efficient than the R-290 circuit, at normal operating conditions for frozen foods or ice cream. Comparison of the experimental result; from the almost fully optimized R-744 freezer with a standard R-290 freezer at an ambient temperature of 30C shows that the R-744 freezer is only 13% less efficient than the R-290 freezer at an average product temperature of 23C. The differences between the ideal and the real loops are analyzed. Finally, costs of major components of both systems are evaluated. This shows that the difference in production costs between an R-744 and an R-290 freezer is mainly driven by the compressor. [Dutch] Een experimentele en analytische vergelijking is uitgvoerd tussen R-744 (CO2) en R-290 (propaan) als koudemiddel in kleine vriezer-toepassingen. Een standaard vrieskist voor de verkoop van ijs en voorzien van een hermetische R-290 compressor is geconverteerd naar R-744, gebruikmakend van standaard componenten en een semi-hermetische R-744 compressor. De resultaten van energiegebruik- en temperatuurprestatietesten uitgevoerd

Manumycin A Is a Potent Inhibitor of Mammalian Thioredoxin Reductase-1 (TrxR-1).

Science.gov (United States)

Tuladhar, Anupama; Rein, Kathleen S

2018-04-12

The anticancer effect of manumycin A (Man A) has been attributed to the inhibition of farnesyl transferase (FTase), an enzyme that is responsible for post-translational modification of Ras proteins. However, we have discovered that Man A inhibits mammalian cytosolic thioredoxin reductase 1 (TrxR-1) in a time-dependent manner, with an IC 50 of 272 nM with preincubation and 1586 nM without preincubation. The inhibition of TrxR-1 by Man A is irreversible and is the result of a covalent interaction between Man A and TrxR-1. Evidence presented herein demonstrates that Man A forms a Michael adduct with the selenocysteine residue, which is located in the C-terminal redox center of TrxR-1. Inhibitors of TrxR-1, which act through this mechanism, convert TrxR-1 into a SecTRAP, which utilizes NADPH to reduce oxygen to superoxide radical anion (O 2 -• ).

77 FR 22321 - National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative...

Science.gov (United States)

2012-04-13

... DEPARTMENT OF HEALTH AND HUMAN SERVICES National Toxicology Program (NTP) Interagency Center for... (HTS) Assays for the Tox21 Initiative AGENCY: Division of the National Toxicology Program (DNTP...: April 5, 2012. John R. Bucher, Associate Director, National Toxicology Program. [FR Doc. 2012-8942 Filed...

75 FR 1796 - National Center for Complementary and Alternative Medicine; Notice of Closed Meetings

Science.gov (United States)

2010-01-13

... Complementary and Alternative Medicine; Notice of Closed Meetings Pursuant to section 10(d) of the Federal..., National Center for Complementary, and Alternative Medicine, NIH, 6707 Democracy Blvd., Suite 401, Bethesda... Alternative Medicine Special Emphasis Panel, Clinical Science-- Review of NCCAM Clinical R21 and K...

Initial mass function in R-associations CMaR1, Mon R1 and Mon R2 from radiodata

International Nuclear Information System (INIS)

Pyatunina, T.B.

1985-01-01

Results of search for compact radiosources in R-associations CMa R1 and Mon R1 carried out with the radiotelescope RATAN-600 at the 7.6-cm wavelength are given. The number of sources found in the association Mon R1 is approximately equal to the expected number of background extragalactic radiosources. In the association CMa R1 seven radiosources of small angular diameter with the flux greater than 30 mJy are found, two of which probably are background sources. A comparison of optical and radiodata on the association CMa R1 and previously published data on the association Mon R2 make it possible to estimate the initial mass function for associations under study: xi(M) infinity Msup(-2.7+-0.7) for stars with M approximately 10Msub(Sun)

Four-dimensional hilbert curves for R-trees

DEFF Research Database (Denmark)

Haverkort, Herman; Walderveen, Freek van

2011-01-01

Two-dimensional R-trees are a class of spatial index structures in which objects are arranged to enable fast window queries: report all objects that intersect a given query window. One of the most successful methods of arranging the objects in the index structure is based on sorting the objects...... according to the positions of their centers along a two-dimensional Hilbert space-filling curve. Alternatively, one may use the coordinates of the objects' bounding boxes to represent each object by a four-dimensional point, and sort these points along a four-dimensional Hilbert-type curve. In experiments...

Pap Smear Abnormalities in Women Admitted to a Tertiary Health Center in Southeast Turkey

Directory of Open Access Journals (Sweden)

Alev Ozer

2014-12-01

Full Text Available Aim: To analyze the cervical cytological abnormalities which are detected in women undergoing Pap screening in a tertiary health care center within Siirt, a southeastern province of Turkey. Material and Method: A total of 3000 women who underwent Pap screening at the study center between January 1, 2009 and December 31, 2009 were recruited for the study. The women who were diagnosed with benign epithelial changes, infectious alterations, as well as atypical squamous cells with undetermined significance (ASC-US, atypical squamous cells of high significance (ASC-H, and low-grade squamous intraepithelial lesion (LSIL were included. Results: Benign epithelial alterations, infectious changes, ASCUS, ASC-H, and LSIL were detected in 83.7%, 15.3%, 0.8%, 0.1% and 0.1% of the Pap smears respectively. A significant correlation was found between the patient age and the histopathological alterations in the Pap smears (r=0.072, p=0.001. Although no correlation could be detected between gravidity and Pap smear results (r=0.033, p=0.067, a significant correlation existed between parity and the histopathological findings within the Pap smears (r=0.051, p=0.005. Interestingly, the Pap smear results were found to be unrelated to socioeconomic status (r=0.088, p=0.168, education level (r=0.048, p=0.257, and smoking habit (r=0.086, p=0.077. Discussion: The present study has reported a value of 1.0% for the overall prevalence of cervical cytological abnormalities, which is much lower than in western countries. Thus, rather than being dependent on the data reported by clinical studies that have been conducted in western countries, Turkish health care policy should be based on the data obtained from national studies.

Pharmacokinetics and Metabolism of (R,R)-Methoxyfenoterol in Rat

OpenAIRE

Siluk, Danuta; Mager, Donald E.; Kim, Hee Seung; Wang, Yan; Furimsky, Anna M.; Ta, Amy; Iyer, Lalitha V.; Green, Carol E.; Wainer, Irving W.

2010-01-01

(R,R)-Fenoterol (Fen), a β2-adrenoceptor agonist, is under clinical investigation in the treatment of congestive heart disease. The pharmacokinetics and metabolism of the 4-methoxyphenyl derivative of (R,R)-Fen, (R,R)-MFen, have been determined following intravenous and oral administration to the rat and compared with corresponding results obtained with (R,R)-Fen. Results of the study suggest that (R,R)-MFen can offer pharmacokinetic and metabolic advantages in comparison to an earlier (R,R)-...

Conception of a computer for the nuclear medical department of the Augsburg hospital center

International Nuclear Information System (INIS)

Graf, G.; Heidenreich, P.

1984-01-01

A computer system based on the Siemens R30 process computer has been employed at the Institute of Nuclear Medicine of the Augsburg Hospital Center since early 1981. This system, including the development and testing of organ-specific evaluation programs, was used as a basis for the conception of the new computer system for the department of nuclear medicine of the Augsburg Hospital Center. The computer system was extended and installed according to this conception when the new 1400-bed hospital was opened in the 3rd phase of construction in autumn 1982. (orig.) [de

Writing Game Center Apps in iOS Bringing Your Players Into the Game

CERN Document Server

Nahavandipoor, Vandad

2011-01-01

Now that Apple has introduced the GameKit framework to its iOS SDK, you can integrate Game Center features directly into your iPhone and iPad apps. This concise cookbook shows you how it's done, with 18 targeted recipes for adding leaderboards, user authentication, achievements, multiplayer games, and many other features. How do you display players' scores and achievements? How do you create Game Center accounts and add friends? Each recipe in this book includes a simple code solution you can put to work immediately, along with a detailed discussion that offers insight into why and how the r

Ultrathin nanocrystalline diamond films with silicon vacancy color centers via seeding by 2 nm detonation nanodiamonds

Czech Academy of Sciences Publication Activity Database

Stehlík, Štěpán; Varga, Marián; Štenclová, Pavla; Ondič, Lukáš; Ledinský, Martin; Pangrác, Jiří; Vaňek, O.; Lipov, J.; Kromka, Alexander; Rezek, Bohuslav

2017-01-01

Roč. 9, č. 44 (2017), s. 38842-38853 ISSN 1944-8244 R&D Projects: GA MŠk(CZ) LD15003; GA ČR(CZ) GBP108/12/G108 Institutional support: RVO:68378271 Keywords : detonation nanodiamond * surface chemistry * hydrogenation * zeta potential * nucleation density * nanocrystalline diamond * SiV center Subject RIV: BM - Solid Matter Physics ; Magnetism OBOR OECD: Condensed matter physics (including formerly solid state physics, supercond.) Impact factor: 7.504, year: 2016

ACToR Chemical Structure processing using Open Source ...

Science.gov (United States)

ACToR (Aggregated Computational Toxicology Resource) is a centralized database repository developed by the National Center for Computational Toxicology (NCCT) at the U.S. Environmental Protection Agency (EPA). Free and open source tools were used to compile toxicity data from over 1,950 public sources. ACToR contains chemical structure information and toxicological data for over 558,000 unique chemicals. The database primarily includes data from NCCT research programs, in vivo toxicity data from ToxRef, human exposure data from ExpoCast, high-throughput screening data from ToxCast and high quality chemical structure information from the EPA DSSTox program. The DSSTox database is a chemical structure inventory for the NCCT programs and currently has about 16,000 unique structures. Included are also data from PubChem, ChemSpider, USDA, FDA, NIH and several other public data sources. ACToR has been a resource to various international and national research groups. Most of our recent efforts on ACToR are focused on improving the structural identifiers and Physico-Chemical properties of the chemicals in the database. Organizing this huge collection of data and improving the chemical structure quality of the database has posed some major challenges. Workflows have been developed to process structures, calculate chemical properties and identify relationships between CAS numbers. The Structure processing workflow integrates web services (PubChem and NIH NCI Cactus) to d

GOES-R Space Weather Data: Achieving User Ready Products

Science.gov (United States)

Rowland, W. F.; Tilton, M.; Redmon, R. J.; Goodman, S. J.; Comerford, M.

2017-12-01

Forecasters and the science community will rely on improved Space Weather products from the next generation of Geostationary Operational Environmental Satellite (GOES-R Series) for decades to come. Many issues must be successfully addressed in order to produce useful products. The instruments themselves and their basic scientific measurements (Level 1b data, i.e. L1b) must be calibrated and validated. Algorithms must be created to transform L1b into the specific environmental parameters that are of interest to forecasters and the community (Level 2+, i.e. L2+). In the case of Space Weather data, because the L2+ products are not generated within the core GOES-R Ground Segment, a separate system had to be developed in order to implement the L2+ products. Finally, the products must be made available to real time and retrospective users, as well as preserved for future generations. We give an overview of the path to production of the GOES-R Space Weather products, and the role of the National Centers for Environmental Information (NCEI) in this process.

Substitution of the CFCs R-11, R-13, R-503, R-13B1, R-113, R-114 and R-12B1 in existing refrigerating, air-conditioning and heat pump systems with refrigerants of low ozone depletion potential in the Federal Republic of Germany. Status report; Ersatz der FCKW R11, R13, R503, R13B1, R113, R114, und R12B1 in bestehenden Kaelte-, Klima- und Waermepumpenanlagen in der Bundesrepublik Deutschland durch Kaeltemittel mit geringem Ozonabbaupotential. Statusbericht

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-11-01

The technical basics and the state of the art for the substitution of the CFC refrigerants R-11, R-13, R-503, R-13B1, R-113, R-114 and R-12B1 in existing refrigeration systems are described and explained. The report contains an overview of the current applications of these refrigerants in the FRG, a review and discussion of existing substitutes, the presentation and evaluation of research and experiences with the conversion to alternative refrigerants, the presentation of the required infrastructure and a discussion of the technical feasibility. The conversion of existing systems to refrigerants of lower ozone depletion potential is in conclusion evaluated with regard to its technical feasibility, environmental relevance and economic efficiency. (orig.) [Deutsch] Es werden die technischen Grundlagen und der Stand der Technik zum Ersatz der FCKW-Kaeltemittel R11, R13, R503, R13B1, R113, R114 und R12B1 in bestehenden Kaelteanlagen dargestellt und erlaeutert. Der Bericht beinhaltet einen Ueberblick ueber die derzeitige Anwendung dieser Kaeltemittel in der BRD, die Vorstellung und Diskussion existierender Ersatzstoffe, die Darstellung und Bewertung der Forschung und Erfahrungen zu Umruestungen auf Ersatzstoffe, die Vorstellung der erforderlichen Infrastruktur und die Diskussion der technischen Durchfuehrbarkeit. Die Umstellung bestehender Anlagen auf Kaeltemittel mit geringerem Ozonabbaupotential wird abschliessend hinsichtlich der technischen Durchfuehrbarkeit, der Umweltrelevanz und der Wirtschaftlichkeit bewertet. (orig.)

Project Plan 7930 Cell G PaR Remote Handling System Replacement

International Nuclear Information System (INIS)

Kinney, Kathryn A.

2009-01-01

For over 40 years the US Department of Energy (DOE) and its predecessors have made Californium-252 ( 252 Cf) available for a wide range of industries including medical, nuclear fuels, mining, military and national security. The Radiochemical Engineering Development Center (REDC) located within the Oak Ridge National Laboratory (ORNL) processes irradiated production targets from the High Flux Isotope Reactor (HFIR). Operations in Building 7930, Cell G provide over 70% of the world's demand for 252 Cf. Building 7930 was constructed and equipped in the mid-1960s. Current operations for 252 Cf processing in Building 7930, Cell G require use of through-the-wall manipulators and the PaR Remote Handling System. Maintenance and repairs for the manipulators is readily accomplished by removal of the manipulator and relocation to a repair shop where hands-on work can be performed in glove boxes. Contamination inside cell G does not currently allow manned entry and no provisions were created for a maintenance area inside the cell. There has been no maintenance of the PaR system or upgrades, leaving operations vulnerable should the system have a catastrophic failure. The Cell G PaR system is currently being operated in a run to failure mode. As the manipulator is now 40+ years old there is significant risk in this method of operation. In 2006 an assessment was completed that resulted in recommendations for replacing the manipulator operator control and power centers which are used to control and power the PaR manipulator in Cell G. In mid-2008 the chain for the bridge drive failed and subsequent examinations indicated several damaged links (see Figure 1). To continue operations the PaR manipulator arm is being used to push and pull the bridge as a workaround. A retrieval tool was fabricated, tested and staged inside Cell G that will allow positioning of the bridge and manipulator arm for removal from the cell should the PaR system completely fail. A fully functioning and

Healthcare resource utilization for anemia management: current practice with erythropoiesis-stimulating agents and the impact of converting to once-monthly C.E.R.A.

Science.gov (United States)

Saueressig, Ulrich; Kwan, Jonathan T C; De Cock, Erwin; Sapède, Claudine

2008-01-01

Background andMethods: A prospective, observational study in 12 German and UK dialysis centers which quantified personnel time for anemia treatment using erythropoiesis-stimulating agents (ESAs). Tasks directly observable were measured through the time-and-motion method; time for non-observable tasks was estimated by healthcare staff. Using activity-based costing methods, time was converted into monetary units. Modeling was used to estimate potential time and cost savings using once-monthly C.E.R.A., a continuous erythropoietin receptor activator. For current ESAs in Germany and the UK, respectively: mean observed time was 1.67 and 2.67 min/patient/administration, corresponding to 31 and 42 days/year/center/100 patients; mean total time/center/100 patients/year was estimated at 79 and 95 days, equivalent to EUR 17,031 and GBP 18,739. Assuming 100% once-monthly C.E.R.A. uptake, the observed time/patient/year may decrease by 79 and 84% in Germany and the UK, respectively, compared with traditional ESAs. Conversion to once-monthly C.E.R.A. may offer the potential to reduce time spent on ESA administration in hemodialysis centers. Copyright 2008 S. Karger AG, Basel.

miR-7 Buffers Differentiation in the Developing Drosophila Visual System.

Science.gov (United States)

Caygill, Elizabeth E; Brand, Andrea H

2017-08-08

The 40,000 neurons of the medulla, the largest visual processing center of the Drosophila brain, derive from a sheet of neuroepithelial cells. During larval development, a wave of differentiation sweeps across the neuroepithelium, converting neuroepithelial cells into neuroblasts that sequentially express transcription factors specifying different neuronal cell fates. The switch from neuroepithelial cells to neuroblasts is controlled by a complex gene regulatory network and is marked by the expression of the proneural gene l'sc. We discovered that microRNA miR-7 is expressed at the transition between neuroepithelial cells and neuroblasts. We showed that miR-7 promotes neuroepithelial cell-to-neuroblast transition by targeting downstream Notch effectors to limit Notch signaling. miR-7 acts as a buffer to ensure that a precise and stereotypical pattern of transition is maintained, even under conditions of environmental stress, echoing the role that miR-7 plays in the eye imaginal disc. This common mechanism reflects the importance of robust visual system development. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Joint Center Estimation Using Single-Frame Optimization: Part 1: Numerical Simulation.

Science.gov (United States)

Frick, Eric; Rahmatalla, Salam

2018-04-04

The biomechanical models used to refine and stabilize motion capture processes are almost invariably driven by joint center estimates, and any errors in joint center calculation carry over and can be compounded when calculating joint kinematics. Unfortunately, accurate determination of joint centers is a complex task, primarily due to measurements being contaminated by soft-tissue artifact (STA). This paper proposes a novel approach to joint center estimation implemented via sequential application of single-frame optimization (SFO). First, the method minimizes the variance of individual time frames’ joint center estimations via the developed variance minimization method to obtain accurate overall initial conditions. These initial conditions are used to stabilize an optimization-based linearization of human motion that determines a time-varying joint center estimation. In this manner, the complex and nonlinear behavior of human motion contaminated by STA can be captured as a continuous series of unique rigid-body realizations without requiring a complex analytical model to describe the behavior of STA. This article intends to offer proof of concept, and the presented method must be further developed before it can be reasonably applied to human motion. Numerical simulations were introduced to verify and substantiate the efficacy of the proposed methodology. When directly compared with a state-of-the-art inertial method, SFO reduced the error due to soft-tissue artifact in all cases by more than 45%. Instead of producing a single vector value to describe the joint center location during a motion capture trial as existing methods often do, the proposed method produced time-varying solutions that were highly correlated ( r > 0.82) with the true, time-varying joint center solution.

Joint Center Estimation Using Single-Frame Optimization: Part 1: Numerical Simulation

Directory of Open Access Journals (Sweden)

Eric Frick

2018-04-01

Full Text Available The biomechanical models used to refine and stabilize motion capture processes are almost invariably driven by joint center estimates, and any errors in joint center calculation carry over and can be compounded when calculating joint kinematics. Unfortunately, accurate determination of joint centers is a complex task, primarily due to measurements being contaminated by soft-tissue artifact (STA. This paper proposes a novel approach to joint center estimation implemented via sequential application of single-frame optimization (SFO. First, the method minimizes the variance of individual time frames’ joint center estimations via the developed variance minimization method to obtain accurate overall initial conditions. These initial conditions are used to stabilize an optimization-based linearization of human motion that determines a time-varying joint center estimation. In this manner, the complex and nonlinear behavior of human motion contaminated by STA can be captured as a continuous series of unique rigid-body realizations without requiring a complex analytical model to describe the behavior of STA. This article intends to offer proof of concept, and the presented method must be further developed before it can be reasonably applied to human motion. Numerical simulations were introduced to verify and substantiate the efficacy of the proposed methodology. When directly compared with a state-of-the-art inertial method, SFO reduced the error due to soft-tissue artifact in all cases by more than 45%. Instead of producing a single vector value to describe the joint center location during a motion capture trial as existing methods often do, the proposed method produced time-varying solutions that were highly correlated (r > 0.82 with the true, time-varying joint center solution.

75 FR 25273 - National Center on Minority and Health Disparities; Notice of Closed Meeting

Science.gov (United States)

2010-05-07

... and Health Disparities; Notice of Closed Meeting Pursuant to section 10(d) of the Federal Advisory... and Health Disparities Special Emphasis Panel, Faith Based R21. Date: June 29-July 1, 2010. Time: 5 p..., Chief, Office of Scientific Review, National Center on Minority Health and Health Disparities, 6707...

75 FR 68970 - Amendment of Using Agency for Restricted Areas R-4002, R-4005, R-4006 and R-4007; MD

Science.gov (United States)

2010-11-10

...-1070; Airspace Docket No. 10-AEA-18] RIN 2120-AA66 Amendment of Using Agency for Restricted Areas R-4002, R-4005, R- 4006 and R-4007; MD AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action makes a minor change to the name of the using agency for restricted areas R...

R&W Club Frederick Hosts Second Annual Car Show | Poster

Science.gov (United States)

A 1994 Ford Thunderbird, a 2006 Porsche 911-S, and a 1996 Chevy Camaro Z28 were just a few of the rides on display this summer at R&W Club Frederick’s second annual Car and Motorcycle Show. “It’s a chance to raise money for a good cause,” said Geoff Seidel, one of the organizers of the event and program director for the Coordinating Center for Clinical Trials, NCI Office of

Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients

Directory of Open Access Journals (Sweden)

Qiu Shuwei

2013-01-01

Full Text Available Abstract Background Glioblastoma multiforme (GBM is the most common and aggressive brain tumor with poor clinical outcome. Identification and development of new markers could be beneficial for the diagnosis and prognosis of GBM patients. Deregulation of microRNAs (miRNAs or miRs is involved in GBM. Therefore, we attempted to identify and develop specific miRNAs as prognostic and predictive markers for GBM patient survival. Methods Expression profiles of miRNAs and genes and the corresponding clinical information of 480 GBM samples from The Cancer Genome Atlas (TCGA dataset were downloaded and interested miRNAs were identified. Patients’ overall survival (OS and progression-free survival (PFS associated with interested miRNAs and miRNA-interactions were performed by Kaplan-Meier survival analysis. The impacts of miRNA expressions and miRNA-interactions on survival were evaluated by Cox proportional hazard regression model. Biological processes and network of putative and validated targets of miRNAs were analyzed by bioinformatics. Results In this study, 6 interested miRNAs were identified. Survival analysis showed that high levels of miR-326/miR-130a and low levels of miR-323/miR-329/miR-155/miR-210 were significantly associated with long OS of GBM patients, and also showed that high miR-326/miR-130a and low miR-155/miR-210 were related with extended PFS. Moreover, miRNA-323 and miRNA-329 were found to be increased in patients with no-recurrence or long time to progression (TTP. More notably, our analysis revealed miRNA-interactions were more specific and accurate to discriminate and predict OS and PFS. This interaction stratified OS and PFS related with different miRNA levels more detailed, and could obtain longer span of mean survival in comparison to that of one single miRNA. Moreover, miR-326, miR-130a, miR-155, miR-210 and 4 miRNA-interactions were confirmed for the first time as independent predictors for survival by Cox regression model

Korean interim storage issues and R and D activities on spent fuel management

International Nuclear Information System (INIS)

Ji Sup Yoon; Seung-Gy Ro; Hyun-Soo Park

1999-01-01

Korea has witnessed over a decade of vicissitudes in the issue of radioactive waste management due mainly to the problem of site acquisition. As the major mission of the nation at radioactive waste management programme was to provide a center for disposal of low-level radwaste and for interim storage of spent nuclear fuel from nuclear power plants, the question of site securing has had a big impact on the implement action of overall programme. The site problem has resulted in, as an aftermath, restructuring of the overall programme for radioactive waste management. Missions of NEMAC (Nuclear Environment Management Center), originally established as a subsidiary of Korea Atomic Energy Research Institute (KAERI), for the national programme was dissolved as of the end of last year. Beginning of this year, a new entity NETEC (Nuclear Environment Technology Center) as a subsidiary of KEPCO (Korea Electric Power Co.) has taken over major tasks of the past NEMAC, while the R and D work associated with the past task of NEMAC is transferred back to KAERI. This paper gives a review on the past background which has driven the radioactive waste management in Korea to the current state of the affairs, with special emphasis on R and D activities associated with spent nuclear fuel transportation, handling, and storage. (author)

Thermodynamic comparision of R744/R600a and R744/R600 used in mid-high temperature heat pump system

Directory of Open Access Journals (Sweden)

Fan Xiao-Wei

2014-01-01

Full Text Available The mid-high temperature heat pump provides hot water at a relatively high temperature using some industrial waste heat as its source. Now, the main refrigerants in this application are CFC114, HCFC123, and HCFC142b, etc., which are scheduled to be phased out due to their high ozone depletion potential and global warmth potential. Some studies have been conducted to find an eco-friendly alternative. In this paper, the natural non-azeotropic mixtures R744/R600a and R744/R600 are analyzed as alternatives. The performance of the heat pump system using new mixture is discussed and compared with those with CFC114, HCFC123, and HCFC142b. Under the given operating conditions, the maximum heating COP should occur at the mass fractions of 18/82 for R744/R600a and 10/90 for R744/R600. Both of their COP are higher than those with the refrigerants of CFC114, HCFC123, and HCFC142b. The COP and volumetric heating capacity of the system with R744/R600a are superior to those with R744/R600.

Birth Satisfaction Scale/Birth Satisfaction Scale-Revised (BSS/BSS-R): A large scale United States planned home birth and birth centre survey.

Science.gov (United States)

Fleming, Susan E; Donovan-Batson, Colleen; Burduli, Ekaterina; Barbosa-Leiker, Celestina; Hollins Martin, Caroline J; Martin, Colin R

2016-10-01

to explore the prevalence of birth satisfaction for childbearing women planning to birth in their home or birth centers in the United States. Examining differences in birth satisfaction of the home and birth centers; and those who birthed in a hospital using the 30-item Birth Satisfaction Scale (BSS) and the 10-item Birth Satisfaction Scale-Revised (BSS-R). a quantitative survey using the BSS and BSS-R were employed. Additional demographic data were collected using electronic linkages (Qualtrics ™ ). a convenience sample of childbearing women (n=2229) who had planned to birth in their home or birth center from the US (United States) participated. Participants were recruited via professional and personal contacts, primarily their midwives. the total 30-item BSS score mean was 128.98 (SD 16.92) and the 10-item BSS-R mean score was 31.94 (SD 6.75). Sub-scale mean scores quantified the quality of care provision, women's personal attributes, and stress experienced during labour. Satisfaction was higher for women with vaginal births compared with caesareans deliveries. In addition, satisfaction was higher for women who had both planned to deliver in a home or a birth centre, and who had actually delivered in a home or a birth center. total and subscale birth satisfaction scores were positive and high for the overall sample IMPLICATIONS FOR PRACTICE: the BSS and the BSS-R provide a robust tool to quantify women's experiences of childbirth between variables such as birth types, birth settings and providers. Copyright © 2016 Elsevier Ltd. All rights reserved.

Design of HTS filter for GSM-R communication system

Science.gov (United States)

Cui, Hongyu; Ji, Laiyun

2018-04-01

High-temperature superconducting materials with its excellent performance have increasingly been valued by industries, especially in the field of electronic information. The superconducting material has almost zero surface resistance, and the filter made of it has the characteristics of low insertion loss, high edge steepness and good out-of-band rejection. It has higher selectivity for the desired signal and thus less interference from adjacent channels Signal interference, and noise reduction coefficient can improve the ability to detect weak signals. This design is suitable for high temperature superconducting filter of GSM-R communication system, which can overcome many shortcomings of the traditional GSM-R. The filter is made of DyBCO, a high temperature superconducting thin film material based on magnesium oxide (MgO) substrate with the dielectric constant of 9.7, the center frequency at 887.5MHz, bandwidth of 5MHz.

Enduring relevance: an introduction to the clinical contributions of K. R. Eissler.

Science.gov (United States)

Garcia, Emanuel E

2009-10-01

The author offers a personal selection and discussion of papers that epitomize the enduring relevance of K. R. Eissler's contributions to psychoanalytic therapy. The innovations of technique embodied by these works (on parameters, schizophrenia, adolescence, cure, fees, and the treatment of the dying patient) reveal a therapeutic approach that is a natural extension of psychoanalytic science: patient-centered, maximally comprehensive, and appropriately flexible.

The Precarious Question of Black Cultural Centers Versus Multicultural Centers.

Science.gov (United States)

Princes, Carolyn D. W.

This paper discusses the role of black cultural centers on university campuses, focusing on whether black cultural centers or multicultural centers best meet the needs of an increasingly diverse student body and society. It examines the historical role of black cultural centers as vehicles to promote educational opportunity, student retention, and…

Center Planning and Development Student Engineer at KSC

Science.gov (United States)

Jenkins, Kenneth T., Jr.

2015-01-01

This summer I was the Student Trainee (Engineering) Pathways Intern (co-op) at the Kennedy Space Center (KSC) in the Center Planning & Development (CPD) Directorate. CPD works with commercial companies who are interested in using KSC's unique capabilities for spaceflight, spacecraft processing, ground systems and Research & Development (R&D) projects that fall in line with NASA's Mission and Vision. CPD is divided into three (3) groups: (1) AD-A, which works on the Master Planning for the center, (2) AD-B (where I am), which works on project control, management and integration, and (3) AD-C, which works on partnership development. CPD's main goal is to make KSC the world's preeminent multi-user spaceport and maintain the center as a leader in space exploration. CPD is a very diverse group of employees having a wide knowledge of not only the Space Shuttle, but also Expendable Launch Vehicles (ELV). The director of CPD, Scott Colloredo, is on the advisory board for Commercial Space Operations (CSO) and has a degree from ERAU. I worked on a number of different tasks for AD-B, as well as CPD, that includes, but not limited to: reviewing and reissuing engineering documents, weekly notes for CPD and senior management, engineering familiarizations with facilities at KSC, leading a tour for the Embry-Riddle Aeronautical University Career Services office, and working on actual agreements/proposals that will be used in the partnership process with multiple partners, along with other projects. Most of the work I have done is sensitive information and cannot be disclosed.

DOE R and D data tracking base

International Nuclear Information System (INIS)

Horpedahl, L.; Brooks, M.

2000-01-01

This document consists of DOE R and D tracking information for the following topics: Stockpile Readiness Program; Stockpile Reduction Program; Enduring Stockpile Program; Future Stockpile Program; Archiving; Nuclear Component Assessment; Advanced Application; Validation and Verification; Distance and Distributed Computing; DOD Munitions; Performance Assessment; Physics; Los Alamos Meson Physics Facility/Los Alamos Neutron Science Center; Advanced Hydrodynamic Radiography; Systems Engineering; Advanced Manufacturing; Chemistry and Materials; High Explosives; Special Nuclear Mateirals; Tritium; Collaboration with ASCI; Numeric Environment for Weapons Simulation; Target Physics; Theory and Modeling; Target Development; Fabrication and Handling; Other ICF Activities; Development of Predictive Capabilities--Nuclear; Development of Diagnostic Tools--Nuclear; Process Development; and IPPD/Agile Manufacturing

Computerized adaptive and multistage testing with R using packages catR and mstR

CERN Document Server

Magis, David; von Davier, Alina A

2017-01-01

The goal of this guide and manual is to provide a practical and brief overview of the theory on computerized adaptive testing (CAT) and multistage testing (MST) and to illustrate the methodologies and applications using R open source language and several data examples.  Implementation relies on the R packages catR and mstR that have been already or are being developed by the first author (with the team) and that include some of the newest research algorithms on the topic. The book covers many topics along with the R-code: the basics of R, theoretical overview of CAT and MST, CAT designs, CAT assembly methodologies, CAT simulations, catR package, CAT applications, MST designs, IRT-based MST methodologies, tree-based MST methodologies, mstR package, and MST applications.  CAT has been used in many large-scale assessments over recent decades, and MST has become very popular in recent years.  R open source language also has become one of the most useful tools for applications in almost all fields, including b...

Hydrologic Tests at Characterization Wells R-9i, R-13, R-19, R-22, and R-31, Revision 1

Energy Technology Data Exchange (ETDEWEB)

S.G.McLin; W.J. Stone

2004-06-01

Hydrologic information is essential for environmental efforts at Los Alamos National Laboratory. Testing at new characterization wells being drilled to the regional aquifer (''R wells'') to improve the conceptual hydrogeologic model of the Pajarito Plateau is providing such information. Field tests were conducted on various zones of saturation penetrated by the R wells to collect data needed for determining hydraulic properties. This document provides details of the design and execution of testing as well as an analysis of data for five new wells: R-9i, R-13, R-19, R-22, and R-31. One well (R-13) was evaluated by a pumping test and the rest (R-9i, R-19, R-22, and R-31) were evaluated by injection tests. Characterization well R-9i is located in Los Alamos Canyon approximately 0.3 mi west of the Route 4/Route 502 intersection. It was completed at a depth of 322 ft below ground surface (bgs) in March 2000. This well was constructed with two screens positioned below the regional water table. Both screens were tested. Screen 1 is completed at about 189-200 ft bgs in fractured basalt, and screen 2 is completed at about 270-280 ft bgs in massive basalt. Specific capacity analysis of the screen 1 data suggests that the fractured basalt has a transmissivity (T) of 589 ft{sup 2}/day and corresponds to a hydraulic conductivity (K) of 7.1 ft/day based on a saturated thickness of 83 ft. The injection test data from the massive basalt near screen 2 were analyzed by the Bouwer-Rice slug test methodology and suggest that K is 0.11 ft/day, corresponding to a T of about 2.8 ft{sup 2}/day based on a saturated thickness of 25 ft. Characterization well R-13 is located in Mortandad Canyon just west of the eastern Laboratory boundary. It was completed at a depth of 1029 ft bgs in February 2002. This well was constructed with one 60-ft long screen positioned about 125 ft below the regional water table. This screen is completed at about 958-1019 ft bgs and straddles the

Vapor-liquid critical surface of ternary difluoromethane + pentafluoroethane + 1,1,1,2-tetrafluoroethane (R-32/125/134a) mixtures

Energy Technology Data Exchange (ETDEWEB)

Higashi, Y.

1999-09-01

The plane of vapor-liquid criticality for ternary refrigerant mixtures of difluoromethane (R-32) + pentafluoroethane (R-125) + 1,1,1,2-tetrafluoroethane (R-134a) was determined from data on the vapor-liquid coexistence curve near the mixture critical points. The composition (mass percentage) of the mixtures studied were 23% R-32 + 25% R-125 + 52% R-134a (R-407C). 25% R-32 + 15% R-125 + 60% R-134a (R-407E), and 20% R-32 + 40% R-125 + 40% R-134a (R-407A). The critical temperature of each mixture was determined by observation of the disappearance of the meniscus. The critical density of each mixture was determined on the basis of meniscus disappearance level and the intensity of the critical opalescence. The uncertainties of the temperature, density, and composition measurements are estimated as {+-}10mK, {+-}5kg{center_dot}m{sup {minus}3}, and {+-}0.05%, respectively. In addition, predictive methods for the critical parameters of R-32/125/134a mixtures are discussed.

Surface resistance of RE123 films with artificial pinning centers

International Nuclear Information System (INIS)

Mukaida, M.; Saito, A.; Kita, R.; Matsumoto, K.; Ichinose, A.; Yoshida, Y.; Horii, S.; Yamada, K.; Mori, N.

2006-01-01

Effects of artificial pinning centers (APCs) into ErBa 2 Cu 3 O 7-δ films are discussed. The APCs used in this paper is BaZrO 3 and Zn which are mixed into ErBa 2 Cu 3 O 7-δ ceramic targets. The targets with various contents of APCs are ablated and films are grown on substrates with the APCs. X-ray diffraction patterns show there are no other phases than ErBa 2 Cu 3 O 7-δ and APCs. Transmission electron microscopy (TEM) shows the BaZrO 3 APSs grow along the c-axis of the films. The introduction of APCs decreases surface resistance (R S ) of ErBa 2 Cu 3 O 7-δ films and increases critical current density (J C ) of the films. R S measurements revealed that the ErBa 2 Cu 3 O 7-δ films with APCs showed a lower R S than that of the ErBa 2 Cu 3 O 7-δ films without APCs

Cross-Linked CoMoO4/rGO Nanosheets as Oxygen Reduction Catalyst

Directory of Open Access Journals (Sweden)

Jiaqi Fu

2017-12-01

Full Text Available Development of inexpensive and robust electrocatalysts towards oxygen reduction reaction (ORR is crucial for the cost-affordable manufacturing of metal-air batteries and fuel cells. Here we show that cross-linked CoMoO4 nanosheets and reduced graphene oxide (CoMoO4/rGO can be integrated in a hybrid material under one-pot hydrothermal conditions, yielding a composite material with promising catalytic activity for oxygen reduction reaction (ORR. Cyclic voltammetry (CV and linear sweep voltammetry (LSV were used to investigate the efficiency of the fabricated CoMoO4/rGO catalyst towards ORR in alkaline conditions. The CoMoO4/rGO composite revealed the main reduction peak and onset potential centered at 0.78 and 0.89 V (vs. RHE, respectively. This study shows that the CoMoO4/rGO composite is a highly promising catalyst for the ORR under alkaline conditions, and potential noble metal replacement cathode in fuel cells and metal-air batteries.

Using poison center exposure calls to predict methadone poisoning deaths.

Directory of Open Access Journals (Sweden)

Nabarun Dasgupta

Full Text Available PURPOSE: There are more drug overdose deaths in the Untied States than motor vehicle fatalities. Yet the US vital statistics reporting system is of limited value because the data are delayed by four years. Poison centers report data within an hour of the event, but previous studies suggested a small proportion of poisoning deaths are reported to poison centers (PC. In an era of improved electronic surveillance capabilities, exposure calls to PCs may be an alternate indicator of trends in overdose mortality. METHODS: We used PC call counts for methadone that were reported to the Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS® System in 2006 and 2007. US death certificate data were used to identify deaths due to methadone. Linear regression was used to quantify the relationship of deaths and poison center calls. RESULTS: Compared to decedents, poison center callers tended to be younger, more often female, at home and less likely to require medical attention. A strong association was found with PC calls and methadone mortality (b=0.88, se=0.42, t=9.5, df=1, p<0.0001, R(2 =0.77. These findings were robust to large changes in a sensitivity analysis assessing the impact of underreporting of methadone overdose deaths. CONCLUSIONS: Our results suggest that calls to poison centers for methadone are correlated with poisoning mortality as identified on death certificates. Calls received by poison centers may be used for timely surveillance of mortality due to methadone. In the midst of the prescription opioid overdose epidemic, electronic surveillance tools that report in real-time are powerful public health tools.

AMASYA PUBLIC EDUCATION CENTER WORKS EXAMPLE: YASSIÇAL BROADCLOTH WEAVINGS

Directory of Open Access Journals (Sweden)

Hurrem Sinem SANLI

2015-09-01

Full Text Available Public education aims to gain adults the skills and knowledge towards interpretation of free times of social and cultural activities. With public education, people living in the region especially women contribute to production. In Amasya, there are courses provided for women in Public Education Centers and it is made sure that they attend theses courses. In this study, a section of said center and Yassıçal broadcloth weavings are analyzed. Motifs and product examples in Yassıçal weavings are examined. These motifs are Eminem, Tekke peşkürü, Suleyman, Sinekli, Mehmet Dede, Kara viran, Çift mekik and Deveci kesmesi. This traditional motifs began to weave again. A variety of woven products; living room sets, veil, curtains, runners, bags, doll clothes and women's clothes are produced by traniees.

Calculation of the main neutron parameters of the IEA-R1 research reactor

International Nuclear Information System (INIS)

Ojima, Mario Katsuhiko

1977-01-01

The main neutron parameters of the research reactor IEA-R1 were calculated using computer programs to generate cross sections and criticality calculations. A calculation procedure based on the programs available in the Processing Center Data of IEA was established and centered in the HAMMER and CITATION system. A study was done in order to verify the validity and accuracy of the calculation method comparing the results with experimental data. Some operating parameters of the reactor, namely the distribution of neutron flux, the critical mass, the variation of the reactivity with the burning of fuel, and the dead time of the reactor were determined

Radio evidence for the initial stellar mass function in the R associations CMa R1, Mon R1, Mon R2

International Nuclear Information System (INIS)

Pyatunina, T.B.

1985-01-01

The R associations CMa R1 and Mon R1 have been searched for compact 7.6-cm sources with the RATAN-600 radio telescope. The Mon R1 region shows only about the expected number of background radio galaxies; in CMa R1 seven sources of small angular size with S> or =30 mJy have been found, two of them probably background objects. Comparison with optical data for CMa R1, together with previous RATAN-600 data for Mon R2, yields an initial mass function xi(M)proportionalM/sup -2.7plus-or-minus0.7/ for the rather massive (Mroughly-equal10 M/sub sun/) stars in these associations

Collaborative Product Development in an R&D Environment

Science.gov (United States)

Davis, Jose M.; Keys, L. Ken; Chen, Injazz J.; Peterson, Paul L.

2004-01-01

Research and development (R&D) organizations are being required to be relevant, to be more application-oriented, and to be partners in the strategic management of the business while meeting the same challenges as the rest of the organization, namely: (1) reduced time to market; (2) reduced cost; (3) improved quality; (4) increased reliability; and (5) increased focus on customer needs. Recent advances in computer technology and the Internet have created a new paradigm of collaborative engineering or collaborative product development (CPD), from which new types of relationships among researchers and their partners have emerged. Research into the applicability and benefits of CPD in a low/no production, R&D, and/or government environment is limited. In addition, the supply chain management (SCM) aspects of these relationships have not been studied. This paper presents research conducted at the NASA Glenn Research Center (GRC) investigating the applicability of CPD and SCM in an R&D organization. The study concentrates on the management and implementation of space research activities at GRC. Results indicate that although the organization is engaged in collaborative relationships that incorporate aspects of SCM, a number of areas, such as development of trust and information sharing merit special attention.

Development of computational science in JAEA. R and D of simulation

International Nuclear Information System (INIS)

Nakajima, Norihiro; Araya, Fumimasa; Hirayama, Toshio

2006-01-01

R and D of computational science in JAEA (Japan Atomic Energy Agency) is described. Environment of computer, R and D system in CCSE (Center for Computational Science and e-Systems), joint computational science researches in Japan and world, development of computer technologies, the some examples of simulation researches, 3-dimensional image vibrational platform system, simulation researches of FBR cycle techniques, simulation of large scale thermal stress for development of steam generator, simulation research of fusion energy techniques, development of grid computing technology, simulation research of quantum beam techniques and biological molecule simulation researches are explained. Organization of JAEA, development of computational science in JAEA, network of JAEA, international collaboration of computational science, and environment of ITBL (Information-Technology Based Laboratory) project are illustrated. (S.Y.)

An Optimization of (Q,r Inventory Policy Based on Health Care Apparel Products with Compound Poisson Demands

Directory of Open Access Journals (Sweden)

An Pan

2014-01-01

Full Text Available Addressing the problems of a health care center which produces tailor-made clothes for specific people, the paper proposes a single product continuous review model and establishes an optimal policy for the center based on (Q,r control policy to minimize expected average cost on an order cycle. A generic mathematical model to compute cost on real-time inventory level is developed to generate optimal order quantity under stochastic stock variation. The customer demands are described as compound Poisson process. Comparisons on cost between optimization method and experience-based decision on Q are made through numerical studies conducted for the inventory system of the center.

FY 1994 report on the results of the R and D of solid oxide fuel cells (SOFC); 1994 nendo SOFC kotai denkaishitsugata nenryo denchi no kenkyu kaihatsu seika hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-05-01

Development of fuel cell power generation technology and R and D of solid oxide fuel cells were carried out, and reports of the FY 1994 results of companies were summed up. As to the R and D of the cell module, R and D were conducted of 'large area cell' by Fuji Electric Corporate R and D, Ltd. and 'combined cell module' by Sanyo Electric Co. As to the R and D of materials/basic technology, the following were conducted: 'R and D of the electrode micro structure' by Japan Fine Ceramics Center, 'R and D of the electrode structure by thermal spraying method by Fujikura Ltd., 'R and D of the multi-functional fuel electrode' by Mitsubishi Heavy Industries, Ltd., 'R and D of the cofiring technology' by Murata Mfg. Co., and 'R and D of the current collecting technology' by Mitsui Engineering and Shipbuilding Co. Concerning the R and D of the system, 'the system study' by Central Research Institute of Electric Power Industry' and 'development of element technology for periphery devices' by The Japan Research and Development Center for Metals. (NEDO)

Důvody vzniku a systém provozování vybraných lanových center v ČR

OpenAIRE

Kreutz, Petr

2011-01-01

Title: The reasons for building and operation system of selected rope courses centers in Czech republic. Objectives: Objective of this thesis is looking for main motivation for building rope courses centers in our country, which groups of people attending them mostly, how the price was set or how often new obstacles are building there. Methods: All data in this thesis were collected by questionnaire and telefonic interview with operators of rope courses centres. Results: Most of operators, wh...

Flow condensation heat transfer coefficients of R22, R134a, R407C, and R410A inside plain and microfin tubes

Energy Technology Data Exchange (ETDEWEB)

Jung, Dongsoo; Cho, Youngmok; Park, Kiho [Inha Univ., Incheon (Korea). Dept. of Mechanical Engineering

2004-01-01

Flow condensation heat transfer coefficients (HTCs) of R22, R134a, R407C, and R410A inside horizontal plain and microfin tubes of 9.52 mm outside diameter and 1 m length were measured at the condensation temperature of 40{sup o}C with mass fluxes of 100, 200, and 300 kg m{sup -2} s{sup -1} and a heat flux of 7.7-7.9 kW m{sup -2}. For a plain tube, HTCs of R134a and R410A were similar to those of R22 while HTCs of R407C are 11-15% lower than those of R22. For a microfin tube, HTCs of R134a were similar to those of R22 while HTCs of R407C and R410A were 23-53% and 10-21% lower than those of R22. For a plain tube, our correlation agreed well with the present data for all refrigerants exhibiting a mean deviation of 11.6%. Finally, HTCs of a microfin tube were 2-3 times higher than those of a plain tube and the heat transfer enhancement factor decreased as the mass flux increased for all refrigerants tested. (Author)

[The Engineering and Technical Services Directorate at the Glenn Research Center

Science.gov (United States)

Moon, James

2004-01-01

My name is James Moon and I am a senior at Tennessee State University where my major is Aeronautical and Industrial Technology with a concentration in industrial electronics. I am currently serving my internship in the Engineering and Technical Services Directorate at the Glenn Research Center (GRC). The Engineering and Technical Service Directorate provides the services and infrastructure for the Glenn Research Center to take research concepts to reality. They provide a full range of integrated services including engineering, advanced prototyping and testing, facility management, and information technology for NASA, industry, and academia. Engineering and Technical Services contains the core knowledge in Information Technology (IT). This includes data systems and analysis, inter and intranet based systems design and data security. Including the design and development of embedded real-time s o h a r e applications for flight and supporting ground systems, Engineering and Technical Services provide a wide range of IT services and products specific to the Glenn Research Center research and engineering community. In the 7000 Directorate I work directly in the 7611 organization. This organization is known as the Aviation Environments Technical Branch. My mentor is Vincent Satterwhite who is also the Branch Chief of the Aviation Environments Technical Branch. In this branch, I serve as the Assistant program manager of the Engineering Technology Program. The Engineering Technology Program (ETP) is one of three components of the High School L.E.R.C.I.P. This is an Agency-sponsored, eight-week research-based apprenticeship program designed to attract traditionally underrepresented high school students that demonstrate an aptitude for and interest in mathematics, science, engineering, and technology.

R graphics

CERN Document Server

Murrell, Paul

2005-01-01

R is revolutionizing the world of statistical computing. Powerful, flexible, and best of all free, R is now the program of choice for tens of thousands of statisticians. Destined to become an instant classic, R Graphics presents the first complete, authoritative exposition on the R graphical system. Paul Murrell, widely known as the leading expert on R graphics, has developed an in-depth resource that takes nothing for granted and helps both neophyte and seasoned users master the intricacies of R graphics. After an introductory overview of R graphics facilities, the presentation first focuses

Review of Studies of the Economic Impact of the September 11, 2001, Terrorist Attacks on the World Trade Center

Science.gov (United States)

2002-05-29

of the Budget, • New York City Partnership and Chamber of Commerce , Washington, DC 20548 Report Documentation Page Report Date 29MAY2002 Report Type...700R Impact of Terrorist Attacks on the World Trade Center 10 Eight Studies (cont’d) ! New York City Partnership and Chamber of Commerce , Economic...Center 29 Observations Observations The New York City Partnership and Chamber of Commerce study generated the most comprehensive estimates—direct and

FED-R2: concept and magnet design of a low-cost FED

International Nuclear Information System (INIS)

Williams, J.E.C.; Becker, H.; Blackfield, D.; Bobrov, E.; Bromberg, L.; Cohn, D.R.; Diatchenko, N.; LeClaire, R.

1982-12-01

High performance resistive magnet technology was used to develop a design for a compact, low cost version of the fusion engineering device FED. We refer to this design as FED-R2, for FED-resistive magnet design 2 to distinguish it from the larger resistive magnet design for FED which uses demountable coils (FED-R1). The main objectives of FED-R2 are: (1) to demonstrate reliable, quasi-steady state (long pulse, high duty factor) operation with Q/sub p/ approx. 5; (2) to demonstrate Q/sub p/ > 5 operation for a limited number of pulses; (3) to provide high neutron flux for irradiation of nuclear test modules with a total area greater tha 20m 2 ; (4) to utilize steady-state RF current drive if this option appears promising. Based upon the costing codes at the Fusion Engineering Design Center and upon TFTR costs, the estimated direct costs of FED-R2 would be on the range 380 to 460M, a factor of about 2 below that of the baseline FED design

Clinical relevance of microRNA miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145 in colorectal cancer

International Nuclear Information System (INIS)

Schee, Kristina; Boye, Kjetil; Abrahamsen, Torveig Weum; Fodstad, Øystein; Flatmark, Kjersti

2012-01-01

MicroRNAs (miRNAs) regulate gene expression by binding to mRNA, and can function as oncogenes or tumor suppressors depending on the target. In this study, using qRT-PCR, we examined the expression of six miRNAs (miR-21, miR-31, miR-92a, miR-101, miR-106a and miR-145) in tumors from 193 prospectively recruited patients with colorectal cancer, and associations with clinicopathological parameters and patient outcome were analyzed. The miRNAs were chosen based on previous studies for their biomarker potential and suggested biological relevance in colorectal cancer. The miRNA expression was examined by qRT-PCR. Associations between miRNA expression and clinicopathological variables were explored using Mann–Whitney U and Kruskal-Wallis test while survival was estimated using the Kaplan-Meier method and compared using the log-rank test. MiR-101 was hardly expressed in the tumor samples, while for the other miRNAs, variable expression levels and expression ranges were observed, with miR-21 being most abundantly expressed relative to the reference (RNU44). In our study cohort, major clinical significance was demonstrated only for miR-31, as high expression was associated with advanced tumor stage and poor differentiation. No significant associations were found between expression of the investigated miRNAs and metastasis-free or overall survival. Investigating the expression of six miRNAs previously identified as candidate biomarkers in colorectal cancer, few clinically relevant associations were detected in our patient cohort. Our results emphasize the importance of validating potential tumor markers in independent patient cohorts, and indicate that the role of miRNAs as colorectal cancer biomarkers is still undetermined

Space - A unique environment for process modeling R&D

Science.gov (United States)

Overfelt, Tony

1991-01-01

Process modeling, the application of advanced computational techniques to simulate real processes as they occur in regular use, e.g., welding, casting and semiconductor crystal growth, is discussed. Using the low-gravity environment of space will accelerate the technical validation of the procedures and enable extremely accurate determinations of the many necessary thermophysical properties. Attention is given to NASA's centers for the commercial development of space; joint ventures of universities, industries, and goverment agencies to study the unique attributes of space that offer potential for applied R&D and eventual commercial exploitation.

R&D for Future Accelerators

CERN Document Server

Zimmermann, Frank

2006-01-01

Research & development for future accelerators are reviewed. First, I discuss colliding hadron beams, in particular upgrades to the Large Hadron Collider (LHC). This is followed by an overview of new concepts and technologies for lepton ring colliders, with examples taken from VEPP-2000, DAFNE-2, and Super-KEKB. I then turn to recent progress and studies for the multi-TeV Compact Linear Collider (CLIC). Some generic linear-collider research, centered at the KEK Accelerator Test Facility, is described next. Subsequently, I survey the neutrino factory R&D performed in the framework of the US feasibility study IIa, and I also comment on a novel scheme for producing monochromatic neutrinos from an electron-capture beta beam. Finally, I present innovative ideas for a high-energy muon collider and I consider recent experimental progress on laser and plasma acceleration.

Estimation of the center of rotation using wearable magneto-inertial sensors.

Science.gov (United States)

Crabolu, M; Pani, D; Raffo, L; Cereatti, A

2016-12-08

Determining the center of rotation (CoR) of joints is fundamental to the field of human movement analysis. CoR can be determined using a magneto-inertial measurement unit (MIMU) using a functional approach requiring a calibration exercise. We systematically investigated the influence of different experimental conditions that can affect precision and accuracy while estimating the CoR, such as (a) angular joint velocity, (b) distance between the MIMU and the CoR, (c) type of the joint motion implemented, (d) amplitude of the angular range of motion, (e) model of the MIMU used for data recording, (f) amplitude of additive noise on inertial signals, and (g) amplitude of the errors in the MIMU orientation. The evaluation process was articulated at three levels: assessment through experiments using a mechanical device, mathematical simulation, and an analytical propagation model of the noise. The results reveal that joint angular velocity significantly impacted CoR identification, and hence, slow joint movement should be avoided. An accurate estimation of the MIMU orientation is also fundamental for accurately subtracting the contribution owing to gravity to obtain the coordinate acceleration. The unit should be preferably attached close to the CoR, but both type and range of motion do not appear to be critical. When the proposed methodology is correctly implemented, error in the CoR estimates is expected to be <3mm (best estimates=2±0.5mm). The findings of the present study foster the need to further investigate this methodology for application in human subjects. Copyright © 2016 Elsevier Ltd. All rights reserved.

Trend Extraction in Functional Data of Amplitudes of R and T Waves in Exercise Electrocardiogram

Science.gov (United States)

Cammarota, Camillo; Curione, Mario

The amplitudes of R and T waves of the electrocardiogram (ECG) recorded during the exercise test show both large inter- and intra-individual variability in response to stress. We analyze a dataset of 65 normal subjects undergoing ambulatory test. We model the dataset of R and T series in the framework of functional data, assuming that the individual series are realizations of a non-stationary process, centered at the population trend. We test the time variability of this trend computing a simultaneous confidence band and the zero crossing of its derivative. The analysis shows that the amplitudes of the R and T waves have opposite responses to stress, consisting respectively in a bump and a dip at the early recovery stage. Our findings support the existence of a relationship between R and T wave amplitudes and respectively diastolic and systolic ventricular volumes.

The miR-449b polymorphism, rs10061133 A>G, is associated with premature ovarian insufficiency.

Science.gov (United States)

Pan, Hong; Chen, Beili; Wang, Jing; Wang, Xi; Hu, Ping; Wu, Shinan; Liu, Yunyun; Xu, Zuying; Zhang, Wei; Wang, Binbin; Cao, Yunxia

2016-09-01

To determine if the miR-449b polymorphism, rs10061133 A>G, is associated with premature ovarian insufficiency (POI) pathogenesis. From January 2011 to December 2014, a total of 148 individuals with POI and 225 age-matched controls were collected from the Center for Reproductive Medicine, 1st Affiliated Hospital of Anhui Medical University (Hefei, China). Genotyping of miR-449b rs1006113 was performed using matrix-assisted laser desorption ionization time-of-flight-based mass spectrometry. Rs10061133 A>G is a highly conserved SNP locus in the mature area of miR-449b. Association analysis shows that the rs10061133 AA genotype is a risk factor for POI. Our study provides the first evidence that the miR-449b rs10061133 AA genotype is associated with POI risk.

[The Problems with Domestic Introduction of rTMS from the Three Viewpoints of Scientific Evidence, Specialty and Social Responsibility].

Science.gov (United States)

Shinosaki, Kazuhiro

2015-01-01

The domestic introduction of rTMS is expected as a new treatment option for treatment-resistant depression. I discussed some problems with the introduction from three viewpoints : scientific evidence, specialty, and social responsibility. I surveyed scientific evidence for rTMS regarding the action mechanism, effectiveness, side effects, and its positioning in the treatment guidelines. To secure the quality of rTMS treatment, I proposed rTMS guidelines, nurturing of the specialists, and a center hospital plan, and pointed out some medium-term problems after its introduction and the consistency of rTMS treatment and standard depression treatment. From the viewpoint of social responsibility, rTMS treatment should be a medical service covered by health insurance to avoid its misuse. We should prepare to overcome the public suspicion of brain stimulation treatment for mental disease.

Thermodynamics of {l_brace}zNaCl+(1-z)Na{sub 2}SO{sub 4}{r_brace}(aq) from T=278.15 K to T=318.15 K, and representation with an extended ion-interaction (Pitzer) model

Energy Technology Data Exchange (ETDEWEB)

Rard, Joseph A. E-mail: rard1@llnl.gov; Clegg, Simon L.; Platford, Robert

2003-06-01

In 1968, R.F. Platford reported the results from extensive isopiestic vapor-pressure measurements for the {l_brace}zNaCl+(1-z)Na{sub 2}SO{sub 4}{r_brace}(aq) system at T=298.15 K, using NaCl(aq) as the isopiestic reference standard [R.F. Platford, J. Chem. Eng. Data 13 (1968) 46-48]. However, only derived quantities were reported, and the experimental isopiestic equilibrium molalities were not given. The complete set of original isopiestic molalities from that study is tabulated in the present report. In addition, published thermodynamic information for this system is reviewed and the isopiestic equilibrium molalities, electromotive force measurements for five different types of electrochemical cells, and enthalpies of mixing from these other studies are critically assessed and recalculated consistently. These combined results are used to evaluate at T=298.15 K the two mixing parameters of Pitzer's ion-interaction model, {sup S}{theta}(Cl,SO{sub 4})=(1.236{+-}0.032{sub 5}){center_dot}10{sup -2} kg{center_dot}mol{sup -1} and {psi}(Na,Cl,SO{sub 4})=(1.808{+-}0.086){center_dot}10{sup -3} kg{sup 2}{center_dot}mol{sup -2}, and their temperature derivatives {l_brace}{partial_derivative}{sup S}{theta}(Cl,SO{sub 4})/{partial_derivative}T{r_brace}{sub p}=(2.474{+-}0.460){center_dot}10{sup -5} kg{center_dot}mol{sup -1}{center_dot}K{sup -1} and {l_brace}{partial_derivative}{psi}(Na,Cl,SO{sub 4})/{partial_derivative}T{r_brace}{sub p}=-(6.228{+-}0.186){center_dot}10{sup -5} kg{sup 2}{center_dot}mol{sup -2}{center_dot}K{sup -1}. Also reported are parameters for an extended ion-interaction model for Na{sub 2}SO{sub 4}(aq), valid from T=(273.15 to 323.15) K, that were required for this mixed electrolyte solution analysis.

Analysis of determinations of the distance between the sun and the galactic center

Science.gov (United States)

Malkin, Z. M.

2013-02-01

The paper investigates the question of whether or not determinations of the distance between the Sun and the Galactic center R 0 are affected by the so-called "bandwagon effect", leading to selection effects in published data that tend to be close to expected values, as was suggested by some authors. It is difficult to estimate numerically a systematic uncertainty in R 0 due to the bandwagon effect; however, it is highly probable that, even if widely accepted values differ appreciably from the true value, the published results should eventually approach the true value despite the bandwagon effect. This should be manifest as a trend in the published R 0 data: if this trend is statistically significant, the presence of the bandwagon effect can be suspected in the data. Fifty two determinations of R 0 published over the last 20 years were analyzed. These data reveal no statistically significant trend, suggesting they are unlikely to involve any systematic uncertainty due to the bandwagon effect. At the same time, the published data show a gradual and statistically significant decrease in the uncertainties in the R 0 determinations with time.

Combined Neutron Center for European Research and Technology

International Nuclear Information System (INIS)

Lagniel, Jean-Michel

2002-01-01

High-power proton linacs are needed as driver for several applications, namely transmutation of nuclear waste using Accelerator Driven Systems (ADS), spallation neutron sources (ESS in Europe) and other fields of basic and applied research (next generation of radioactive ion beam facilities, neutrino factories, muon colliders, irradiation facilities for material testing...). The possible synergies among these projects will be pointed out and the feasibility study of high-power proton linac used as driver of a multi-user facility (CONCERT) will be presented. There was excellent scientific, technical and economic reasons to study a Combined Neutron Center for European Research and Technology (CONCERT) based on a high-power proton accelerator. Such an installation would serve condensed matter studies by spallation neutron scattering, a technological irradiation tool and R and D facility for an hybrid reactor demonstrator, a radioactive ion beam facility for nuclear physics, R and D developments for a muon/neutrino facility. The installation could therefore constitute a European center of excellence in the field of neutronics where a large number of scientific and technical executives could be trained. The CONCERT Project Team has performed the feasibility study of such a multi-user facility with: - a review of the beam needs for the different applications, - an analyze of their compatibility, - the definition of the scope of a site-independent project, - a selection of the most appropriate options regarding scientific, technical, financial, organizational and administrative aspects, - an estimation of the costs for construction, operation and the needs in manpower. The conceptual design report [17] is sufficiently detailed to minimize contingencies on those parts of the project having a large potential impact in terms of performances, costs or delays. (author)

A criticality result for polycycles in a family of quadratic reversible centers

Science.gov (United States)

Rojas, D.; Villadelprat, J.

2018-06-01

We consider the family of dehomogenized Loud's centers Xμ = y (x - 1)∂x + (x + Dx2 + Fy2)∂y, where μ = (D , F) ∈R2, and we study the number of critical periodic orbits that emerge or disappear from the polycycle at the boundary of the period annulus. This number is defined exactly the same way as the well-known notion of cyclicity of a limit periodic set and we call it criticality. The previous results on the issue for the family {Xμ , μ ∈R2 } distinguish between parameters with criticality equal to zero (regular parameters) and those with criticality greater than zero (bifurcation parameters). A challenging problem not tackled so far is the computation of the criticality of the bifurcation parameters, which form a set ΓB of codimension 1 in R2. In the present paper we succeed in proving that a subset of ΓB has criticality equal to one.

The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics

DEFF Research Database (Denmark)

Long, K. S.; Poehlsgaard, Jacob; Kehrenberg, C.

2006-01-01

to overlapping sites at the peptidyl transferase center that abut nucleotide A2503, is perturbed upon Cfr-mediated methylation. Decreased drug binding to Cfr-methylated ribosomes has been confirmed by footprinting analysis. No other rRNA methyltransferase is known to confer resistance to five chemically distinct...

78 FR 63867 - Change of Using Agency for Restricted Areas R-5115, NM, and R-6316, R-6317, and R-6318, TX

Science.gov (United States)

2013-10-25

... realignment of organizational responsibilities between federal agencies, U.S. Customs and Border Protection..., R-6317, and R-6318 in Texas. The transfer of using agency operational control occurs October 1, 2013...-6316, R- 6317, and R-6318 to reflect current organizational responsibilities. Environmental Review The...

Financing R&D Projects in Southern Italy: The “Technological Vouchers and Cooperative Research” Program

Directory of Open Access Journals (Sweden)

Gianpaolo Iazzolino

2013-09-01

Full Text Available The paper deals with the evaluation and financing of research and innovation projects. The paper analyzes and discusses the “Technological Vouchers and Cooperative Research” program in the Calabria Region (Southern Italy, as a program for financing R&D projects in a geographical area far behind in development. Three real cases of R&D projects are described. The program was effective as regards the stimulus to realizing R&D activities by Calabrian SMEs and furthermore in relation to the improvement of cooperation between SMEs, research centers, universities and technological laboratories. The weak points of the program mainly regard the evaluation phase that made it impossible to get a feedback useful for policy and for driving future agenda.

Using R via PHP for Teaching Purposes: R-php

Directory of Open Access Journals (Sweden)

Angelo Mineo

2006-10-01

Full Text Available This paper deals with the R-php statistical software, that is an environment for statistical analysis, freely accessible and attainable through the World Wide Web, based on R. Indeed, this software uses, as “engine” for statistical analyses, R via PHP and its design has been inspired by a paper of de Leeuw (1997. R-php is based on two modules: a base module and a point-and-click module. R-php base allows the simple editing of R code in a form. R-php point-and-click allows some statistical analyses by means of a graphical user interface (GUI: then, to use this module it is not necessary for the user to know the R environment, but all the allowed analyses can be performed by using the computer mouse. We think that this tool could be particularly useful for teaching purposes: one possible use could be in a University computer laboratory to permit a smooth approach of students to R.

The center for plant and microbial complex carbohydrates at the University of Georgia Complex Carbohydrate Research Center

Energy Technology Data Exchange (ETDEWEB)

Albersheim, P.; Darvill, A.

1991-08-01

Research from the Complex Carbohydrates Research Center at the University of Georgia is presented. Topics include: Structural determination of soybean isoflavones which specifically induce Bradyrhizobium japonicum nodD1 but not the nodYABCSUIJ operon; structural analysis of the lipopolysaccharides (LPSs) from symbiotic mutants of Bradyrhizobium japonicum; structural characterization of lipooligosaccharides from Bradyrhizobium japonicum that are required for the specific nodulation of soybean; structural characterization of the LPSs from R. Leguminosarum biovar phaseoli, the symbiont of bean; characterization of bacteroid-specific LPS epitopes in R. leguminosarum biovar viciae; analysis of the surface polysaccharides of Rhizobium meliloti mutants whose lipopolysaccharides and extracellular polysaccharides can have the same function in symbiosis; characterization of a polysaccharide produced by certain Bradyrhizobium japonicum strains within soybean nodules; structural analysis of a streptococcal adhesin polysaccharide receptor; conformational studies of xyloglucan, the role of the fucosylated side chain in surface-specific cellulose-xyloglucan interactions; the structure of an acylated glucosamine oligosaccharide signal molecule (nod factor) involved in the symbiosis of Rhizobium leguminosarum biovar viciae with its host Vicia sativa; investigating membrane responses induced by oligogalacturonides in cultured cells; the polygalacturonase inhibitor protein; characterization of the self-incompatability glycoproteins from Petunia hybrida; investigation of the cell wall polysaccharide structures of Arabidopsis thaliana; and the glucan inhibition of virus infection of tabacco.

77 FR 31018 - Board of Scientific Counselors (BSC), National Center for Injury Prevention and Control (NCIPC)

Science.gov (United States)

2012-05-24

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Centers for Disease Control and Prevention Board of... Violence or Sexual Violence Perpetration (R01), FOA CE12-003. In accordance with Section 10(a)(2) of the..., discussion of competitive applications following initial review of applications received in response to FOA...

Safety management of a complex R and D ground operating system

Science.gov (United States)

Connors, J. F.; Maurer, R. A.

1975-01-01

A perspective on safety program management was developed for a complex R&D operating system, such as the NASA-Lewis Research Center. Using a systems approach, hazardous operations are subjected to third-party reviews by designated-area safety committees and are maintained under safety permit controls. To insure personnel alertness, emergency containment forces and employees are trained in dry-run emergency simulation exercises. The keys to real safety effectiveness are top management support and visibility of residual risks.

1 r urT log ),( r t lim ),( ) ( , urT urrT r r

African Journals Online (AJOL)

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dθ where u+(z) = max(u(z), 0). The lower order λ of u is given by λ = lim r. urT log. ),(. A sequence {rn} of positive numbers is said to be a sequence of Pólya peaks for T(r, u) of order λ > 0 if there is a sequence {∈n}, ∈n > 0 such that ∈n → 0.

tgcd: An R package for analyzing thermoluminescence glow curves

Directory of Open Access Journals (Sweden)

Jun Peng

2016-01-01

Full Text Available Thermoluminescence (TL glow curves are widely used in dosimetric studies. Many commercial and free-distributed programs are used to deconvolute TL glow curves. This study introduces an open-source R package tgcd to conduct TL glow curve analysis, such as kinetic parameter estimation, glow peak simulation, and peak shape analysis. TL glow curves can be deconvoluted according to the general-order empirical expression or the semi-analytical expression derived from the one trap-one recombination center (OTOR model based on the Lambert W function by using a modified Levenberg–Marquardt algorithm from which any of the parameters can be constrained or fixed. The package provides an interactive environment to initialize parameters and offers an automated “trial-and-error” protocol to obtain optimal fit results. First-order, second-order, and general-order glow peaks (curves are simulated according to a number of simple kinetic models. The package was developed using a combination of Fortran and R programming languages to improve efficiency and flexibility.

Stephenson Cancer Center

Science.gov (United States)

Stephenson Cancer Center at the University of Oklahoma in Oklahoma City is an NCI-designated cancer center at the forefront of NCI-supported cancer research. Learn more about the Stephenson Cancer Center's mission.

FY 1994 report on the results of the R and D of solid oxide fuel cells (SOFC); 1994 nendo SOFC kotai denkaishitsugata nenryo denchi no kenkyu kaihatsu seika hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-05-01

Development of fuel cell power generation technology and R and D of solid oxide fuel cells were carried out, and reports of the FY 1994 results of companies were summed up. As to the R and D of the cell module, R and D were conducted of 'large area cell' by Fuji Electric Corporate R and D, Ltd. and 'combined cell module' by Sanyo Electric Co. As to the R and D of materials/basic technology, the following were conducted: 'R and D of the electrode micro structure' by Japan Fine Ceramics Center, 'R and D of the electrode structure by thermal spraying method by Fujikura Ltd., 'R and D of the multi-functional fuel electrode' by Mitsubishi Heavy Industries, Ltd., 'R and D of the cofiring technology' by Murata Mfg. Co., and 'R and D of the current collecting technology' by Mitsui Engineering and Shipbuilding Co. Concerning the R and D of the system, 'the system study' by Central Research Institute of Electric Power Industry' and 'development of element technology for periphery devices' by The Japan Research and Development Center for Metals. (NEDO)

R

Directory of Open Access Journals (Sweden)

Ravšelj Dejan

2017-06-01

Full Text Available Investment in research and development (R&D plays a vital role in economic growth. Therefore, the crucial role of government is to encourage companies to develop new knowledge, skills, and innovations in order to achieve greater competitiveness, employment creation, and economic development. The aim of this paper is to determine whether R&D subsidies contribute to corporate performance and ascertain whether the relationship between the amount of R&D subsidies and corporate performance is moderated by Slovenian cohesion (NUTS 2 level and statistical (NUTS 3 level regions. This paper ultimately tries to classify statistical regions within meaningful groups. Using an OLS regression, a unique dataset of 407 Slovenian companies is analysed for 2014. The empirical results reveal that R&D subsidies have a positive impact on corporate performance and confirm that cohesion and statistical regions can moderate the effect of R&D subsidy on corporate performance. Moreover, the paper provides for the classification of Slovenian statistical regions into four groups.

Spin reorientation phenomena in (R{sub 1-x}R`{sub x}){sub 2}Co{sub 14}B (R = La, R` = Dy and Ho)

Energy Technology Data Exchange (ETDEWEB)

Myojin, T. [Takamatsu Nat. Coll. of Technol. (Japan); Ohno, T. [Tokushima Univ. (Japan). Faculty of Engineering; Mizuno, K. [Tokushima Univ. (Japan). Faculty of Integrated Arts and Sciences; Tsujimura, A. [Faculty of Engineering, Tokushima Bunri Univ., Kagawa Shido (Japan); Kojima, K. [Hiroshima Univ. (Japan). Faculty of Integrated Arts and Sciences

1997-07-01

The variations of magnetization with temperature in (La{sub 1-x}R`{sub x}){sub 2}Co{sub 14}B (R` = Dy and Ho) have been measured to determine spin reorientation temperature T{sub SR} of these compounds. The phase diagrams of spin arrangement thus obtained indicate monotonous increase in T{sub SR} with R` concentration x. Also, T{sub SR}`s of R{sub 2}Co{sub 14}B(R = Tb, Dy and Ho) are found to vary linearly with the Stevens factor {alpha} of R. (orig.). 4 refs.

Nuclear R and D program in Indonesia and selection of future research reactor to support it

International Nuclear Information System (INIS)

Baiquni, A.; Subki, I.

1981-01-01

The nuclear R and D program selection decision is described as a phased program, each phase having its specific objective. The elements of each phase are identified and related with the objective, from which the activities of each element are also broadly outlined. To support the nuclear R and D program and to realize the objectives in each phase, the research facilities are also developed. A new nuclear development center housing a multipurpose reactor (MPR) and various laboratories are also described. The choice of the MPR and its criteria are also described briefly

Engineer Research and Development Center's Materials Testing Center (MTC)

Data.gov (United States)

Federal Laboratory Consortium — The Engineer Research and Development Center's Materials Testing Center (MTC) is committed to quality testing and inspection services that are delivered on time and...

The period function of the generalized Lotka-Volterra centers

Science.gov (United States)

Villadelprat, J.

2008-05-01

The present paper deals with the period function of the quadratic centers. In the literature different terminologies are used to classify these centers, but essentially there are four families: Hamiltonian, reversible , codimension four Q4 and generalized Lotka-Volterra systems . Chicone [C. Chicone, Review in MathSciNet, Ref. 94h:58072] conjectured that the reversible centers have at most two critical periods, and that the centers of the three other families have a monotonic period function. With regard to the second part of this conjecture, only the monotonicity of the Hamiltonian and Q4 families [W.A. Coppel, L. Gavrilov, The period function of a Hamiltonian quadratic system, Differential Integral Equations 6 (1993) 1357-1365; Y. Zhao, The monotonicity of period function for codimension four quadratic system Q4, J. Differential Equations 185 (2002) 370-387] has been proved. Concerning the family, no substantial progress has been made since the middle 80s, when several authors showed independently the monotonicity of the classical Lotka-Volterra centers [F. Rothe, The periods of the Volterra-Lokta system, J. Reine Angew. Math. 355 (1985) 129-138; R. Schaaf, Global behaviour of solution branches for some Neumann problems depending on one or several parameters, J. Reine Angew. Math. 346 (1984) 1-31; J. Waldvogel, The period in the Lotka-Volterra system is monotonic, J. Math. Anal. Appl. 114 (1986) 178-184]. By means of the first period constant one can easily conclude that the period function of the centers in the family is monotone increasing near the inner boundary of its period annulus (i.e., the center itself). Thus, according to Chicone's conjecture, it should be also monotone increasing near the outer boundary, which in the Poincaré disc is a polycycle. In this paper we show that this is true. In addition we prove that, except for a zero measure subset of the parameter plane, there is no bifurcation of critical periods from the outer boundary. Finally we

Perilaku Kreatif Pekerja Call Center: Peran Komunikasi dan Dukungan Training Center

Directory of Open Access Journals (Sweden)

Nugroho J. Setiadi

2013-11-01

Full Text Available Call center business in Indonesia is growing rapidly worldwide. This condition has had repercussions for a growing number of call center workers needed. They are forced to be more creative in performing their duties. This study aims to determine the role of communication and training center in supporting the creative performance of workers in call centers. The survey was conducted by distributing questionnaires to 100 respondents (employees of the 3 major companies in the field of telecommunication services in Indonesia. Regression analysis was used to analyze the data to examine the role of communication and training support center on creative performance. The results indicated that communication and training support center significantly influence the creative behavior in call center workers. Communication quality shown in the telecommunication service provider companies, such as the media quality, simplicity of information, dissemination of information, loads of information, and accuracy of messages, has shown good quality. In addition, the training program has shown its support for call center workers in the form of program effectiveness through research and data collection, determining the materials, training methods, choosing a coach, preparing facilities, selecting and implementing the program.

At R407/R408

CERN Multimedia

1974-01-01

R407/R408 were experiments designed by the CERN-Collège de France-Heidelberg-Karlsruhe Collaboration to study two-particle correlations in the fragmentation region requiring a large transverse momentum particle in the forward direction. Atmospheric pressure Cerenkov counters were part of the additional equipment set up during 1974 at the SFM facility. Here Paul Hanke multi-reflected on Cerenkov mirrors.

Trauma Center Staffing, Infrastructure, and Patient Characteristics that Influence Trauma Center Need

Directory of Open Access Journals (Sweden)

Faul, Mark

2014-11-01

Full Text Available Introduction: The most effective use of trauma center resources helps reduce morbidity and mortality, while saving costs. Identifying critical infrastructure characteristics, patient characteristics and staffing components of a trauma center associated with the proportion of patients needing major trauma care will help planners create better systems for patient care.   Methods: We used the 2009 National Trauma Data Bank-Research Dataset to determine the proportion of critically injured patients requiring the resources of a trauma center within each Level I-IV trauma center (n=443. The outcome variable was defined as the portion of treated patients who were critically injured. We defined the need for critical trauma resources and interventions (“trauma center need” as death prior to hospital discharge, admission to the intensive care unit, or admission to the operating room from the emergency department as a result of acute traumatic injury. Generalized Linear Modeling (GLM was used to determine how hospital infrastructure, staffing Levels, and patient characteristics contributed to trauma center need.     Results: Nonprofit Level I and II trauma centers were significantly associated with higher levels of trauma center need. Trauma centers that had a higher percentage of transferred patients or a lower percentage of insured patients were associated with a higher proportion of trauma center need.  Hospital infrastructure characteristics, such as bed capacity and intensive care unit capacity, were not associated with trauma center need. A GLM for Level III and IV trauma centers showed that the number of trauma surgeons on staff was associated with trauma center need. Conclusion: Because the proportion of trauma center need is predominantly influenced by hospital type, transfer frequency, and insurance status, it is important for administrators to consider patient population characteristics of the catchment area when planning the

User-centered design

International Nuclear Information System (INIS)

Baik, Joo Hyun; Kim, Hyeong Heon

2008-01-01

The simplification philosophy, as an example, that both of EPRI-URD and EUR emphasize is treated mostly for the cost reduction of the nuclear power plants, but not for the simplification of the structure of user's tasks, which is one of the principles of user-centered design. A user-centered design is a philosophy based on the needs and interests of the user, with an emphasis on making products usable and understandable. However, the nuclear power plants offered these days by which the predominant reactor vendors are hardly user-centered but still designer-centered or technology-centered in viewpoint of fulfilling user requirements. The main goal of user-centered design is that user requirements are elicited correctly, reflected properly into the system requirements, and verified thoroughly by the tests. Starting from the user requirements throughout to the final test, each requirement should be traceable. That's why requirement traceability is a key to the user-centered design, and main theme of a requirement management program, which is suggested to be added into EPRI-URD and EUR in the section of Design Process. (author)

Aerial view of the Kennedy Space Center Visitor Center

Science.gov (United States)

1998-01-01

The Kennedy Space Center Visitor Center, shown in this aerial view looking south, sprawls across 70 acres on Florida's Space Coast , and is located off State Road 405, NASA Parkway, six miles inside the Space Center entrance. SR 405 can be seen at the bottom of the photo. Just above the roadway, from left can be seen the Shuttle/Gantry mockup; the Post Show Dome; the Astronaut Memorial; and to the far right, the Center for Space Education. Behind the Memorial are a cluster of buildings that include the Theater Complex, Cafeteria, Space Flight Exhibit Building, Souvenir Sales Building, Spaceport Central, and Ticket Pavilion. At the upper right are various rockets that have played a significant role in the growth of the space program.

Percepcja stylu kierowania przełożonego a zadowolenie z pracy wśród pracowników call center.

OpenAIRE

Drzewiecka, Magda

2010-01-01

The purpose of this article was to find the answer to the question whether gender and leadership style are related to job satisfaction among call center employees. 105 participants (74 women and 31 men) aged 19-52 years filled out Work Description Inventory, Mood at Workplace Questionnaire and Style of Leadership Questionnaire (based on theoretical 3D model by Reddin). Results show that only one leadership style dimension "concern for people" influences call center employees’ cognitive and em...

MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity

Energy Technology Data Exchange (ETDEWEB)

Weber, Martina; Baker, Meredith B.; Moore, Jeffrey P. [Division of Cardiology, Emory University, 1639 Pierce Drive, WMB 319, Atlanta, GA 30322 (United States); Searles, Charles D., E-mail: csearle@emory.edu [Division of Cardiology, Emory University, 1639 Pierce Drive, WMB 319, Atlanta, GA 30322 (United States); Atlanta Veterans Administration Medical Center, 1670 Clarimont Road, Decatur, GA 30033 (United States)

2010-03-19

Mechanical forces associated with blood flow play an important role in regulating vascular signaling and gene expression in endothelial cells (ECs). MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the expression of genes involved in diverse cell functions, including differentiation, growth, proliferation, and apoptosis. miRNAs are known to have an important role in modulating EC biology, but their expression and functions in cells subjected to shear stress conditions are unknown. We sought to determine the miRNA expression profile in human ECs subjected to unidirectional shear stress and define the role of miR-21 in shear stress-induced changes in EC function. TLDA array and qRT-PCR analysis performed on HUVECs exposed to prolonged unidirectional shear stress (USS, 24 h, 15 dynes/cm{sup 2}) identified 13 miRNAs whose expression was significantly upregulated (p < 0.05). The miRNA with the greatest change was miR-21; it was increased 5.2-fold (p = 0.002) in USS-treated versus control cells. Western analysis demonstrated that PTEN, a known target of miR-21, was downregulated in HUVECs exposed to USS or transfected with pre-miR-21. Importantly, HUVECs overexpressing miR-21 had decreased apoptosis and increased eNOS phosphorylation and nitric oxide (NO{sup {center_dot}}) production. These data demonstrate that shear stress forces regulate the expression of miRNAs in ECs, and that miR-21 influences endothelial biology by decreasing apoptosis and activating the NO{sup {center_dot}} pathway. These studies advance our understanding of the mechanisms by which shear stress forces modulate vascular homeostasis.

Wound care centers

Science.gov (United States)

Pressure ulcer - wound care center; Decubitus ulcer - wound care center; Diabetic ulcer - wound care center; Surgical wound - wound ... Common types of non-healing wounds include: Pressure sores Surgical ... flow, or swollen legs Certain wounds may not heal well due to: ...

"Great aspirations: The postwar American college counseling center": Correction to McCarthy (2014).

Science.gov (United States)

2018-05-01

Reports an error in "Great aspirations: The postwar American college counseling center" by Tom McCarthy ( History of Psychology , 2014[Feb], Vol 17[1], 1-18). In the article, the copyright attribution was incorrect. The copyright is "In the public domain". The online version of this article has been corrected. (The following abstract of the original article appeared in record 2014-04967-001.) In the decade after World War II, psychologists, eager to bring the benefits of counseling to larger numbers, convinced hundreds of American colleges and universities to establish counseling centers. Inspired by the educational-vocational counseling center founded by psychologists at the University of Minnesota in 1932, Carl R. Rogers's "client-centered" methods of personal adjustment counseling, and the 400-plus college counseling centers created by the Veterans Administration to provide the educational-vocational counseling benefit promised to returning World War II servicemen under the 1944 GI Bill, these counseling psychologists created a new place to practice where important currents in psychology, higher education, and federal policy converged and where they attempted to integrate educational-vocational counseling with personal adjustment counseling based on techniques from psychotherapy. By the mid-1960s, half of America's colleges and universities had established counseling centers, and more than 90% offered students educational, vocational, and psychological counseling services, a great achievement of the first generation of counseling psychologists. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Status of neutrino factory and muon collider R and D

International Nuclear Information System (INIS)

Zisman, M.S.

2001-01-01

A significant worldwide R and D effort is presently directed toward solving the technical challenges of producing, cooling, accelerating, storing, and eventually colliding beams of muons. Its primary thrust is toward issues critical to a Neutrino Factory, for which R and D efforts are under way in the U.S., via the Neutrino Factory and Muon Collider Collaboration (MC); in Europe, centered at CERN; and in Japan, at KEK. Under study and experimental development are production targets handling intense proton beams (1-4 MW), phase rotation systems to reduce beam energy spread, cooling channels to reduce transverse beam emittance for the acceleration system, and storage rings where muon decays in a long straight section provide a neutrino beam for a long-baseline (3000 km) experiment. Critical experimental activities include development of very high gradient normal conducting RF (NCRF) and superconducting RF (SCRF) cavities, high-power liquid-hydrogen absorbers, and high-field superconducting solenoids. Components and instrumentation that tolerate the intense decay products of the muon beam are being developed for testing. For a high-luminosity collider, muons must be cooled longitudinally as well as transversely, requiring an emittance exchange scheme. In addition to the experimental R and D effort, sophisticated theoretical and simulation tools are needed for the design. Here, the goals, present status, and future R and D plans in these areas will be described

Aplicación de la Escala de Depresión del Center of Epidemiological Studies en adolescentes de la Ciudad de México Application of the revised version of the Center of Epidemiological Studies Depression Scale in adolescent students from Mexico City

Directory of Open Access Journals (Sweden)

Catalina González-Forteza

2008-08-01

Full Text Available OBJETIVO: Probar la validez de constructo, concurrente y externa, y la consistencia interna de la Escala de Depresión del Center for Epidemiologic Studies (CES-D-R en adolescentes. MATERIAL Y MÉTODOS: Estudio transversal con dos cohortes de estudiantes de secundaria del DF. El cuestionario incluyó la CES-D-R y otras escalas sobre problemas relacionados con suicidio, violencia, exposición a oportunidades y consumo de drogas. La participación fue voluntaria y anónima. RESULTADOS: Se incluyó a 1 549 estudiantes (edad promedio, 14 años; DE=1.2. La escala mostró una estructura de seis factores (varianza explicada, 55%, consistencia interna excelente (a=0.93, discriminación significativa entre puntajes extremos (z=-3.695, pOBJECTIVE: To assess the internal consistency, as well as the construct, concurrent and external consistency of the Center for Epidemiologic Studies Depression Scale (CES-D-R in Mexican adolescents. MATERIAL AND METHODS: The data are from two samples of middle-school students from Mexico City. The questionnaire included the CES-D-R and other scales for suicide problems, peer and family violence, and drug use. RESULTS: The sample included 1 549 students (mean age 14 years, SD=1.2. The CES-D-R showed a six-factor structure (explained variance, 55% with an excellent internal consistency (a=0.93, a significant discriminative power for opposite scores (z=-3.695, p<0.001, and a positive significant correlation with the Roberts Suicidal Ideation Scale (r=0.685, p<0.001. CONCLUSIONS: The CES-D-R has excellent psychometric characteristics for Mexican adolescents and therefore is deemed as an adequate tool for the assessment of depressive symptoms in large samples to detect mental health needs and design preventive interventions.

Performance of R290 and R1270 for R22 applications with evaporator and condenser temperature variation

International Nuclear Information System (INIS)

Park, Ki Jung; Jung, Dong Soo

2008-01-01

In this study, therma l performance of two hydrocarbon refrigerants of R290 and R1270 was measured in an attempt to substitute R22. They were tested in a heat pump bench tester of 1 ton capacity with a hermetic rotary compressor. Water and water/glycol mixture were employed as the secondary heat transfer fluids in the test bench. All tests were conducted under the same external conditions simulating three different air-conditioning and heat pumping conditions. Test results show that the coefficient of performance of these hydrocarbon refrigerants is up to 11.5% higher than that of R22 under all conditions. Refrigeration capacity of R290 is up to 8.2% lower than that of R22 under normal airconditioning and heat pumping conditions. Under extremely cold temperature conditions, however, the capacity of R290 is 5% higher than that of R22. On the other hand, the capacity of R1270 is similar to that of R22 under all conditions. Compressor discharge temperatures of these hydrocarbons are reduced by 14-31 .deg. C as compared to R22. The amount of charge is reduced up to 58% as compared to R22. Overall, these hydrocarbons provide good performance with reasonable energy savings without any environmental problems and thus can be used as long-term alternatives for residential air-conditioning and heat pumping applications

The studies of geometrical microstructure of tetragonal Co sup 2 sup + -V sub O centers in KNbO sub 3 and KTaO sub 3 crystals from EPR data

CERN Document Server

Zheng Wen Chen

2002-01-01

From the perturbation formulas for the EPR g factors g sub p sub a sub r sub a sub l sub l sub e sub l and g sub p sub e sub r sub p sub e sub n sub d sub i sub c sub u sub l sub a sub r sub t sub o of a 3d sup 7 ion in tetragonal octahedral crystal field based on a cluster approach, the geometrical microstructures of tetragonal Co sup 2 sup + -V sub O centers in KNbO sub 3 and KTaO sub 3 crystals are obtained by fitting the calculated g sub p sub a sub r sub a sub l sub l sub e sub l and g sub p sub e sub r sub p sub e sub n sub d sub i sub c sub u sub l sub a sub r sub t sub o to the observed values. It is found that the Co sup 2 sup + ion in Co sup 2 sup + -V sub O centers is displaced away from the oxygen vacancy V sub O by 0.3 A in KNbO sub 3 and by 0.29 A in KTaO sub 3. These results are comparable with those of Fe sup 3 sup + -V sub O centers in ABO sub 3 perovskite-type crystals obtained from both the shell-model simulations and the embedded-cluster calculations, and from theoretical studies of EPR da...

77 FR 22691 - Fees on Health Insurance Policies and Self-Insured Plans for the Patient-Centered Outcomes...

Science.gov (United States)

2012-04-17

... 1545-BK59 Fees on Health Insurance Policies and Self-Insured Plans for the Patient-Centered Outcomes... certain health insurance policies and plan sponsors of certain self-insured health plans to fund the... health insurance policies) or R. Lisa Mojiri-Azad at (202) 622-6080 (regarding self- insured health...

MiR-223 suppresses cell proliferation by targeting IGF-1R.

Directory of Open Access Journals (Sweden)

Cheng You Jia

Full Text Available To study the roles of microRNA-223 (miR-223 in regulation of cell growth, we established a miR-223 over-expression model in HeLa cells infected with miR-223 by Lentivirus pLL3.7 system. We observed in this model that miR-223 significantly suppressed the proliferation, growth rate, colony formation of HeLa cells in vitro, and in vivo tumorigenicity or tumor formation in nude mice. To investigate the mechanisms involved, we scanned and examined the potential and putative target molecules of miR-223 by informatics, quantitative PCR and Western blot, and found that insulin-like growth factor-1 receptor (IGF-1R was the functional target of miR-223 inhibition of cell proliferation. Targeting IGF-1R by miR-223 was not only seen in HeLa cells, but also in leukemia and hepatoma cells. The downstream pathway, Akt/mTOR/p70S6K, to which the signal was mediated by IGF-1R, was inhibited as well. The relative luciferase activity of the reporter containing wild-type 3'UTR(3'untranslated region of IGF-1R was significantly suppressed, but the mutant not. Silence of IGF-1R expression by vector-based short hairpin RNA resulted in the similar inhibition with miR-223. Contrarily, rescued IGF-1R expression in the cells that over-expressed miR-223, reversed the inhibition caused by miR-223 via introducing IGF-1R cDNA that didn't contain the 3'UTR. Meanwhile, we also noted that miR-223 targeted Rasa1, but the downstream molecules mediated by Rasa1 was neither targeted nor regulated. Therefore we believed that IGF-1R was the functional target for miR-223 suppression of cell proliferation and its downstream PI3K/Akt/mTOR/p70S6K pathway suppressed by miR-223 was by targeting IGF-1R.

Electronic structure of C r2AlC as observed by angle-resolved photoemission spectroscopy

Science.gov (United States)

Ito, Takahiro; Pinek, Damir; Fujita, Taishi; Nakatake, Masashi; Ideta, Shin-ichiro; Tanaka, Kiyohisa; Ouisse, Thierry

2017-11-01

We investigate the electronic band structure and Fermi surfaces (FSs) of C r2AlC single crystals with angle-resolved photoemission spectroscopy. We evidence hole bands centered around the M points and electron bands centered around the Γ point in reciprocal space. Electron and hole bands exhibit an open, tubular structure along the c axis, confirming the quasi-two-dimensional character of this highly anisotropic, nanolamellar compound. Dependence of the photoionization cross sections on beam light polarization and orientation allows us to assess the orbital character of each observed band locally. Despite some differences, density functional theory calculations show a good agreement with experiment.

R$_{b}$ - R$_{c}$ crisis and new physics

CERN Document Server

Bhattacharya, G; Hou Wei Shu; Bhattacharyya, Gautam; Branco, Gustavo C; Hou, Wei Shu

1996-01-01

The experimental values of R_b and R_c are the only data which do not seem to agree with Standard Model predictions. Although it is still premature to draw any definite conclusions, it is timely to look for new physics which could explain the excess in R_b and deficit in R_c. We investigate this problem in a simple extension of the Standard Model, where a charge +2/3 isosinglet quark is added to the standard spectrum. Upon the further introduction of an extra scalar doublet, one finds a solution with interesting consequences.

Data Center Tasking.

Science.gov (United States)

Temares, M. Lewis; Lutheran, Joseph A.

Operations tasking for data center management is discussed. The original and revised organizational structures of the data center at the University of Miami are also described. The organizational strategy addresses the functions that should be performed by the data center, anticipates the specialized skills required, and addresses personnel…

Metaprogramming in R

DEFF Research Database (Denmark)

Mailund, Thomas

Learn how to manipulate functions and expressions to modify how the R language interprets itself. This book is an introduction to metaprogramming in the R language, so you will write programs to manipulate other programs. Metaprogramming in R shows you how to treat code as data that you can...... generate, analyze, or modify. R is a very high-level language where all operations are functions and all functions are data that can be manipulated. This book shows you how to leverage R's natural flexibility in how function calls and expressions are evaluated, to create small domain-specific languages...... to extend R within the R language itself. You will: Find out about the anatomy of a function in R Look inside a function call Work with R expressions and environments Manipulate expressions in R Use substitutions...

Metaprogramming in R

DEFF Research Database (Denmark)

Mailund, Thomas

2017-01-01

Learn how to manipulate functions and expressions to modify how the R language interprets itself. This book is an introduction to metaprogramming in the R language, so you will write programs to manipulate other programs. Metaprogramming in R shows you how to treat code as data that you can...... generate, analyze, or modify. R is a very high-level language where all operations are functions and all functions are data that can be manipulated. This book shows you how to leverage R's natural flexibility in how function calls and expressions are evaluated, to create small domain-specific languages...... to extend R within the R language itself. You will: Find out about the anatomy of a function in R Look inside a function call Work with R expressions and environments Manipulate expressions in R Use substitutions...

A Study of Civilian Registered Nurse Recruitment at Madigan Army Medical Center, Tacoma, Washington.

Science.gov (United States)

1982-06-01

34 May, 1981, "Nurse, Where Are You?" Judy Armstrong . 5 1nitial Report and Preliminary Recommendations, National Commission on Nursing (September 1981...Interview with Ms. R. Marsh, Staffing Specialist, Force Develop- ment Division, Madigan Army Medical Center, Tacoma, WA (Dec 81) 20Philip Kotler ...Marketing Management. Boston: Allyn and Bacon, Inc., 1980. Kotler , Philip. Marketing for Nonprofit Institutions. Englewood Cliffs, N.D.: Prentice-Hall

Real world data on young patients with high-risk diffuse large B-cell lymphoma treated with R-CHOP or R-CHOEP - MYC, BCL2 and BCL6 as prognostic biomarkers.

Directory of Open Access Journals (Sweden)

Mette Ølgod Pedersen

Full Text Available Double expression of MYC and BCL2 proteins (DE and double-hit MYC+BCL2/BCL6 translocations (DH were established as important biomarkers in patients with diffuse large B-cell lymphoma (DLBCL by the 2016 revision of the World Health Organization classification of lymphoid neoplasms. Whether this applies to the subgroup of young patients with high risk DLBCL is not known. We previously found that in a uniform retrospective population-based cohort of patients aged 18-60 years with high-risk DLBCL, the addition of etoposide to R-CHOP chemotherapy (R-CHOEP resulted in improved survival mainly in patients with germinal center B-cell like (GCB immunophenotype. The aim of this study was to investigate the prognostic and predictive value of DE and DH in this patient cohort.Data on all young Danish patients diagnosed with de novo high-risk DLBCL 2004-2008 and treated with R-CHOP or R-CHOEP were obtained from the Danish Lymphoma database (n = 159. Tumor samples were available from 103 patients. MYC and BCL2 proteins were analyzed with quantitative immunohistochemistry (IHC using different cut off values. MYC-, BCL2- and BCL6-translocations were examined with fluorescent in situ hybridization (FISH.DE with MYC>75% and BCL2>85% was an independent negative prognostic marker of progression free survival (PFS in patients treated with R-CHOP but not R-CHOEP (p<0.001, also after exclusion of patients with DH. A predictive effect of DE for response (PFS to R-CHOEP vs. R-CHOP was almost significant (p = 0.07. DH was not prognostic in this patient cohort.In young patients with high-risk DLBCL, treatment with R-CHOEP may overcome the negative prognostic impact of DE observed in patients treated with R-CHOP.

Radiation induced colour centers and damage in YALO.sub.3./sub.:Ce and YAlO.sub.3./sub.:Ce, Zr scintillators

Czech Academy of Sciences Publication Activity Database

Mareš, Jiří A.; Nikl, Martin; Mihóková, Eva; Solovieva, Natalia; Blažek, K.; Nejezchleb, K.; Malý, P.; Pejchal, J.; Mucka, V.; Pospíšil, M.; Vedda, A.; Martini, M.; Baccaro, S.

2002-01-01

Roč. 157, - (2002), s. 677-681 ISSN 1042-0150 R&D Projects: GA ČR GA202/01/0753 Grant - others:NATO(XX) SfP973510 Institutional research plan: CEZ:AV0Z1010914 Keywords : YAlO 3 :Ce scintillator * Zr 4+ co-doping * gamma-ray irradiation * defect states * colour centers * electron and hole Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.290, year: 2002

Usage Center

DEFF Research Database (Denmark)

Kleinaltenkamp, Michael; Plewa, Carolin; Gudergan, Siegfried

2017-01-01

Purpose: The purpose of this paper is to advance extant theorizing around resourceintegration by conceptualizing and delineating the notion of a usage center. Ausage center consists of a combination of interdependent actors that draw onresources across their individual usage processes to create v...

MYTHONYMICAL SPACE PECULIARITIES IN FOREIGH FANTASY LITERATURE (BASED ON LITERARY WORKS BY J.R.R. TOLKIEN AND G.R.R. MARTIN

Directory of Open Access Journals (Sweden)

Kharitonova, E.V.

2017-12-01

Full Text Available The paper aims at exemplifying the characteristic features of onomastic space of a fantasy text. The authors examine the notion of a ‘mythonym’, systemize different approaches to classifying mythonymical units. The conducted study permitted to work out a thematic classification of mythonyms from the novels “The Lord of the Rings: The Fellowship of the Ring” by J.R.R. Tolkien and “A Song of Ice and Fire: A Game of Thrones” by G.R.R. Martin and to draw the conclusion on mythonyms’ role in fantasy literature.

Bessines: Rebirth of a technological excellence center

International Nuclear Information System (INIS)

2014-06-01

Areva's mining activity is rooted in the Limousin region of central France. For over 65 years, Bessines-sur-Gartempe has been closely involved with global energy and industrial issues. Geologists came here first as explorers, followed by miners and chemical engineers. This is the heritage on which Areva is drawing to help satisfy the steadily growing demand for energy. The SEPA's (Service d'etudes, de Procedes et Analyses) role is to develop new ways to process and use mineral ores. A world renowned R and D center, modernizing its research facilities is a key part of the program to revitalize the Bessines site. Between 1947 and 2001, close to 250 mining sites were exploited in France producing 76,000 tons of uranium. The Areva group (through the CEA and COGEMA) operated 55 % of these sites, all of which have been reclaimed today. UREKA is an educational center created by Areva to inform the public about uranium mining and French know-how in this field. This museum is unique in the world of mining. Depleted uranium is a byproduct of the uranium enrichment process. It harbors real energy potential that Areva intends to tap in the future. The effectiveness of lead-212 in targeting and destroying cancer cells was demonstrated several years ago. The Geosciences Center in made of four entities spread over 4,000 m 2 , regrouping the whole of Areva's mining knowledge and history. The wealth of mineralogical, petrographic and documentary data found there has been accumulated over more than 60 years of exploration and mining

Outcomes of the patients in the respiratory care center are not associated with the seniority of the caring resident

Directory of Open Access Journals (Sweden)

Ming-Ju Tsai

2013-01-01

Full Text Available Although many studies show that the experience level of physicians is significantly associated with the outcomes of their patients, little evidence exists to show whether junior residents provide worse care than senior residents. This study was conducted to analyze whether the experience level of residents may affect the outcomes of patients cared for in a well-organized setting. We conducted a 7-year retrospective study utilizing statistical data from a respiratory care center (RCC in a medical center between October 2004 and September 2011. In addition to the two medical residents who had been trained in the intensive care unit (ICU, the RCC team also included attending physicians in charge, a nurse practitioner, a case manager, a dietitian, a pharmacist, a social worker, registered respiratory therapists, and nursing staff. Weaning from mechanical ventilation was done according to an established weaning protocol. The 84 months analyzed were classified into five groups according to the levels of the two residents working in the RCC: R2 + R1, R2 + R2, R3 + R1, R3 + R2, and R3 + R3. The monthly weaning rate and mortality rate were the major outcomes, while the mean ventilator days, rate of return to the ICU, and nosocomial infection incidence rate were the minor outcomes. The groups did not differ significantly in the monthly weaning rate, mortality rate, mean ventilator days, rate of return to the ICU, or nosocomial infection incidence rate (p > 0.1. Further analysis showed no significant difference in the monthly weaning rate and mortality rate between months with a first-year resident (R1 and those with two senior residents (p > 0.2. Although the weaning rate in the RCC gradually improved over time (p  0.7. Thus, we concluded that in a well-organized setting, the levels (experiences of residents did not significantly affect patient outcomes. This result may be attributed to the well-developed weaning protocol and teamwork

Final report for the DOE Metal Hydride Center of Excellence.

Energy Technology Data Exchange (ETDEWEB)

Keller, Jay O.; Klebanoff, Leonard E.

2012-01-01

This report summarizes the R&D activities within the U.S. Department of Energy Metal Hydride Center of Excellence (MHCoE) from March 2005 to June 2010. The purpose of the MHCoE has been to conduct highly collaborative and multi-disciplinary applied R&D to develop new reversible hydrogen storage materials that meet or exceed DOE 2010 and 2015 system goals for hydrogen storage materials. The MHCoE combines three broad areas: mechanisms and modeling (which provide a theoretically driven basis for pursuing new materials), materials development (in which new materials are synthesized and characterized) and system design and engineering (which allow these new materials to be realized as practical automotive hydrogen storage systems). This Final Report summarizes the organization and execution of the 5-year research program to develop practical hydrogen storage materials for light duty vehicles. Major results from the MHCoE are summarized, along with suggestions for future research areas.

Thermal neutron flux distribution in the ET R R-1 reactor core as experimentally measured and theoretically calculated by the code triton

Energy Technology Data Exchange (ETDEWEB)

Imam, M [National center for nuclear safety and radiation control, atomic energy authority, Cairo, (Egypt)

1995-10-01

Thermal neutron flux distributions that were measured earlier at the ET-R R-1 reactor are compared with those calculated by the three dimensional diffusion code Triton. This comparison was made for the horizontal and vertical flux distributions. The horizontal thermal flux distributions considered in this comparison were along the core diagonals at two planes of different heights from core bottom, where one at a level passing through the control rod at core center and the other at a level below this control rod. In the meantime all the control rods were taken into consideration. The effect of the existence of a water cavity inside the core as well as the influence of the control rods on the thermal flux are illustrated in this work. The vertical thermal flux distributions considered in the comparison were at two positions in core namely; one along the core height the horizontal reactor power distribution along the core height and the horizontal reactor power distribution along the core diagonal as calculated by the code Triton are also given this work. 8 figs., 1 tab.

Degenerate r-Stirling Numbers and r-Bell Polynomials

Science.gov (United States)

Kim, T.; Yao, Y.; Kim, D. S.; Jang, G.-W.

2018-01-01

The purpose of this paper is to exploit umbral calculus in order to derive some properties, recurrence relations, and identities related to the degenerate r-Stirling numbers of the second kind and the degenerate r-Bell polynomials. Especially, we will express the degenerate r-Bell polynomials as linear combinations of many well-known families of special polynomials.

The Survey of Contamination of Platelet Product with Aerobic Bacteria in Isfahan Blood Transfusion Center

Directory of Open Access Journals (Sweden)

F Baghban

2016-09-01

Full Text Available Introduction: Although nowadays the risk of transmission of bacterial pathogens through blood transfusion has been decreased, but there is the possibility of transmission of these factors by injection of these kind of products. The purpose of this survey was determination of contamination of platelet products with aerobic bacteria in Isfahan Blood Transfusion Center. Methods: In the spring and summer of 2014, 2000 platelet product samples were examined randomly in 5 months for aerobic bacterial contamination. First, samples were cultured in fluid thioglycollate medium. The bacteria that were grown in this medium were identified by Gram staining and biochemical tests. Then, DNA was extracted from isolated bacteria and PCR was done for 16S rRNA gene. After that the PCR products were sequenced and the bacteria were recognized at the level of species. Results: At this research, 4 contaminated samples were identified. Isolated bacteria were including: Klebsiella pneumoniae 1 case, Staphylococcus aureus 1 case, Staphylococcus epidermidis 1 case and Staphylococcus haemolyticus 1 case.    After sequencing of 16S rRNA gene, the homology was observed 97%, 83%, 99%, and 90% at theses bacteria, respectively. Discussion: According to the results of this research, platelet products may be contaminated with aerobic bacteria. Therefore, providing appropriate conditions in transfusion centers and other therapeutic centers for doing screening tests on platelet products to identifying bacterial contaminations before using of these products seems to be necessary.

Data Center Energy Efficiency Technologies and Methodologies: A Review of Commercial Technologies and Recommendations for Application to Department of Defense Systems

Science.gov (United States)

2015-11-01

host multiple applications on a single server and split larger applications between multiple servers. If applications can be quickly and easily...improvements are often seen as leading to negative impacts on the organization that operates the DC. Another significant limiting factor for the DoD...34 Renewable and Sustainable Energy Reviews, vol. 31, pp. 622-638, 2014. [152] R. Miller, "Data Center Used to Heat Swimming Pool," Data Center Knowledge, 2

P-R-R Study Technique, Group Counselling And Gender Influence ...

African Journals Online (AJOL)

Read-Recall (P-R-R) study technique and group counselling on the academic performance of senior secondary school students. The objectives of this study were to determine the effect of Group Counselling combined with P-R-R study ...

Early Transition and Use of VIIRS and GOES-R Products by NWS Forecast Offices

Science.gov (United States)

Fuell, Kevin K.; Smith, Mathew; Jedlovec, Gary

2012-01-01

The Visible Infrared Imaging Radiometer Suite (VIIRS) on the NPOESS Preparatory Project (NPP) satellite, part of the Joint Polar Satellite System (JPSS), and the ABI and GLM sensors scheduled for the GOES-R geostationary satellite will bring advanced observing capabilities to the operational weather community. The NASA Short-term Prediction Research and Transition (SPoRT) project at Marshall Space Flight Center has been facilitating the use of real-time experimental and research satellite data by NWS Weather Forecast Offices (WFOs) for a number of years to demonstrate the planned capabilities of future sensors to address particular forecast challenges through improve situational awareness and short-term weather forecasts. For the NOAA GOES-R Proving Ground (PG) activity, SPoRT is developing and disseminating selected GOES-R proxy products to collaborating WFOs and National Centers. SPoRT developed the a pseudo-Geostationary Lightning Mapper product and helped in the transition of the Algorithm Working Group (AWG) Convective Initiation (CI) proxy product for the Hazardous Weather Testbed (HWT) Spring Experiment,. Along with its partner WFOs, SPoRT is evaluating MODIS/GOES Hybrid products, which brings ABI-like data sets from existing NASA instrumentation in front of the forecaster for everyday use. The Hybrid uses near real-time MODIS imagery to demonstrate future ABI capabilities, while utilizing standard GOES imagery to provide the temporal frequency of geostationary imagery expected by operational forecasters. In addition, SPoRT is collaborating with the GOES-R hydrology AWG to transition a baseline proxy product for rainfall rate / quantitative precipitation estimate (QPE) to the OCONUS regions. For VIIRS, SPoRT is demonstrating multispectral observing capabilities and the utility of low-light channels not previously available on operational weather satellites to address a variety of weather forecast challenges. This presentation will discuss the results of

Impact of Center-of-Mass Acceleration on the Performance of Ultramarathon Runners

Directory of Open Access Journals (Sweden)

Lin Shun-Ping

2014-12-01

Full Text Available Ultramarathon races are rapidly gaining popularity in several countries, raising interest for the improvement of training programs. The aim of this study was to use a triaxial accelerometer to compare the three-dimensional centerof- mass accelerations of two groups of ultramarathon runners with distinct performances during different running speeds and distances. Ten runners who participated in the 12-h Taipei International Ultramarathon Race underwent laboratory treadmill testing one month later. They were divided into an elite group (EG; n = 5 and a sub-elite group (SG; n = 5. The triaxial center-of-mass acceleration recorded during a level-surface progressive intensity running protocol (3, 6, 8, 9, 10, and 12 km/h; 5 min each was used for correlation analyses with running distance during the ultramarathon. The EG showed negative correlations between mediolateral (ML acceleration (r = −0.83 to −0.93, p < 0.05, and between anterior-posterior (AP acceleration and running distance (r = −0.8953 to −0.9653, p < 0.05, but not for vertical control of the center of mass. This study suggests that runners reduce stride length to minimize mediolateral sway and the effects of braking on the trunk; moreover, cadence must be increased to reduce braking effects and enhance impetus. Consequently, the competition level of ultramarathons can be elevated.

Hydrologic Engineering Center River Analysis System (HEC-RAS) Water Temperature Models Developed for the Missouri River Recovery Management Plan and Environmental Impact Statement

Science.gov (United States)

2017-09-18

ER D C/ EL T R- 17 -1 8 Missouri River Recovery Program (MRRP) Hydrologic Engineering Center-River Analysis System (HEC-RAS) Water...Zhonglong Zhang and Billy E. Johnson September 2017 Approved for public release; distribution is unlimited. The U.S. Army Engineer Research...and Development Center (ERDC) solves the nation’s toughest engineering and environmental challenges. ERDC develops innovative solutions in civil and

Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine.

Science.gov (United States)

Shirayama, Yukihiko; Hashimoto, Kenji

2018-01-01

(R)-Ketamine exhibits rapid and sustained antidepressant effects in animal models of depression. It is stereoselectively metabolized to (R)-norketamine and subsequently to (2R,6R)-hydroxynorketamine in the liver. The metabolism of ketamine to hydroxynorketamine was recently demonstrated to be essential for ketamine's antidepressant actions. However, no study has compared the antidepressant effects of these 3 compounds in animal models of depression. The effects of a single i.p. injection of (R)-ketamine, (R)-norketamine, and (2R,6R)-hydroxynorketamine in a rat learned helplessness model were examined. A single dose of (R)-ketamine (20 mg/kg) showed an antidepressant effect in the rat learned helplessness model. In contrast, neither (R)-norketamine (20 mg/kg) nor (2R,6R)-hydroxynorketamine (20 and 40 mg/kg) did so. Unlike (R)-ketamine, its metabolite (2R,6R)-hydroxynorketamine did not show antidepressant actions in the rat learned helplessness model. Therefore, it is unlikely that the metabolism of ketamine to hydroxynorketamine is essential for ketamine's antidepressant actions. © The Author 2017. Published by Oxford University Press on behalf of CINP.

SPoRT's Participation in the GOES-R Proving Ground Activity

Science.gov (United States)

Jedlovec, Gary; Fuell, Kevin; Smith, Matthew; Stano, Geoffrey; Molthan, Andrew

2011-01-01

The next generation geostationary satellite, GOES-R, will carry two new instruments with unique atmospheric and surface observing capabilities, the Advanced Baseline Imager (ABI) and the Geostationary Lightning Mapper (GLM), to study short-term weather processes. The ABI will bring enhanced multispectral observing capabilities with frequent refresh rates for regional and full disk coverage to geostationary orbit to address many existing and new forecast challenges. The GLM will, for the first time, provide the continuous monitoring of total lightning flashes over a hemispherical region from space. NOAA established the GOES-R Proving Ground activity several years ago to demonstrate the new capabilities of these instruments and to prepare forecasters for their day one use. Proving Ground partners work closely with algorithm developers and the end user community to develop and transition proxy data sets representing GOES-R observing capabilities. This close collaboration helps to maximize refine algorithms leading to the delivery of a product that effectively address a forecast challenge. The NASA Short-term Prediction Research and Transition (SPoRT) program has been a participant in the NOAA GOES-R Proving Ground activity by developing and disseminating selected GOES-R proxy products to collaborating WFOs and National Centers. Established in 2002 to demonstrate the weather and forecasting application of real-time EOS measurements, the SPoRT program has grown to be an end-to-end research to operations activity focused on the use of advanced NASA modeling and data assimilation approaches, nowcasting techniques, and unique high-resolution multispectral data from EOS satellites to improve short-term weather forecasts on a regional and local scale. Participation in the Proving Ground activities extends SPoRT s activities and taps its experience and expertise in diagnostic weather analysis, short-term weather forecasting, and the transition of research and experimental

ENERGY RESOURCES CENTER

Energy Technology Data Exchange (ETDEWEB)

Sternberg, Virginia

1979-11-01

First I will give a short history of this Center which has had three names and three moves (and one more in the offing) in three years. Then I will tell you about the accomplishments made in the past year. And last, I will discuss what has been learned and what is planned for the future. The Energy and Environment Information Center (EEIC), as it was first known, was organized in August 1975 in San Francisco as a cooperative venture by the Federal Energy Administration (FEA), Energy Research and Development Administration (ERDA) and the Environmental Protection Agency (EPA). These three agencies planned this effort to assist the public in obtaining information about energy and the environmental aspects of energy. The Public Affairs Offices of FEA, ERDA and EPA initiated the idea of the Center. One member from each agency worked at the Center, with assistance from the Lawrence Berkeley Laboratory Information Research Group (LBL IRG) and with on-site help from the EPA Library. The Center was set up in a corner of the EPA Library. FEA and ERDA each contributed one staff member on a rotating basis to cover the daily operation of the Center and money for books and periodicals. EPA contributed space, staff time for ordering, processing and indexing publications, and additional money for acquisitions. The LBL Information Research Group received funds from ERDA on a 189 FY 1976 research project to assist in the development of the Center as a model for future energy centers.

Luminosity measurements for the R scan experiment at BESIII

Science.gov (United States)

Ablikim, M.; Achasov, M. N.; Ahmed, S.; Ai, X. C.; Albayrak, O.; Albrecht, M.; Ambrose, D. J.; Amoroso, A.; An, F. F.; An, Q.; Bai, J. Z.; Bakina, O.; Baldini Ferroli, R.; Ban, Y.; Bennett, D. W.; Bennett, J. V.; Berger, N.; Bertani, M.; Bettoni, D.; Bian, J. M.; Bianchi, F.; Boger, E.; Boyko, I.; Briere, R. A.; Cai, H.; Cai, X.; Cakir, O.; Calcaterra, A.; Cao, G. F.; Cetin, S. A.; Chai, J.; Chang, J. F.; Chelkov, G.; Chen, G.; Chen, H. S.; Chen, J. C.; Chen, M. L.; Chen, S.; Chen, S. J.; Chen, X.; Chen, X. R.; Chen, Y. B.; Chu, X. K.; Cibinetto, G.; Dai, H. L.; Dai, J. P.; Dbeyssi, A.; Dedovich, D.; Deng, Z. Y.; Denig, A.; Denysenko, I.; Destefanis, M.; De Mori, F.; Ding, Y.; Dong, C.; Dong, J.; Dong, L. Y.; Dong, M. Y.; Dou, Z. L.; Du, S. X.; Duan, P. F.; Fan, J. Z.; Fang, J.; Fang, S. S.; Fang, X.; Fang, Y.; Farinelli, R.; Fava, L.; Feldbauer, F.; Felici, G.; Feng, C. Q.; Fioravanti, E.; Fritsch, M.; Fu, C. D.; Gao, Q.; Gao, X. L.; Gao, Y.; Gao, Z.; Garzia, I.; Goetzen, K.; Gong, L.; Gong, W. X.; Gradl, W.; Greco, M.; Gu, M. H.; Gu, Y. T.; Guan, Y. H.; Guo, A. Q.; Guo, L. B.; Guo, R. P.; Guo, Y.; Guo, Y. P.; Haddadi, Z.; Hafner, A.; Han, S.; Hao, X. Q.; Harris, F. A.; He, K. L.; Heinsius, F. H.; Held, T.; Heng, Y. K.; Holtmann, T.; Hou, Z. L.; Hu, C.; Hu, H. M.; Hu, J. F.; Hu, T.; Hu, Y.; Huang, G. S.; Huang, J. S.; Huang, X. T.; Huang, X. Z.; Huang, Z. L.; Hussain, T.; Ikegami Andersson, W.; Ji, Q.; Ji, Q. P.; Ji, X. B.; Ji, X. L.; Jiang, L. W.; Jiang, X. S.; Jiang, X. Y.; Jiao, J. B.; Jiao, Z.; Jin, D. P.; Jin, S.; Johansson, T.; Julin, A.; Kalantar-Nayestanaki, N.; Kang, X. L.; Kang, X. S.; Kavatsyuk, M.; Ke, B. C.; Kiese, P.; Kliemt, R.; Kloss, B.; Kolcu, O. B.; Kopf, B.; Kornicer, M.; Kupsc, A.; Kühn, W.; Lange, J. S.; Lara, M.; Larin, P.; Leithoff, H.; Leng, C.; Li, C.; Li, Cheng; Li, D. M.; Li, F.; Li, F. Y.; Li, G.; Li, H. B.; Li, H. J.; Li, J. C.; Li, Jin; Li, K.; Li, K.; Li, Lei; Li, P. R.; Li, Q. Y.; Li, T.; Li, W. D.; Li, W. G.; Li, X. L.; Li, X. N.; Li, X. Q.; Li, Y. B.; Li, Z. B.; Liang, H.; Liang, Y. F.; Liang, Y. T.; Liao, G. R.; Lin, D. X.; Liu, B.; Liu, B. J.; Liu, C. X.; Liu, D.; Liu, F. H.; Liu, Fang; Liu, Feng; Liu, H. B.; Liu, H. H.; Liu, H. H.; Liu, H. M.; Liu, J.; Liu, J. B.; Liu, J. P.; Liu, J. Y.; Liu, K.; Liu, K. Y.; Liu, L. D.; Liu, P. L.; Liu, Q.; Liu, S. B.; Liu, X.; Liu, Y. B.; Liu, Y. Y.; Liu, Z. A.; Liu, Zhiqing; Loehner, H.; Lou, X. C.; Lu, H. J.; Lu, J. G.; Lu, Y.; Lu, Y. P.; Luo, C. L.; Luo, M. X.; Luo, T.; Luo, X. L.; Lyu, X. R.; Ma, F. C.; Ma, H. L.; Ma, L. L.; Ma, M. M.; Ma, Q. M.; Ma, T.; Ma, X. N.; Ma, X. Y.; Ma, Y. M.; Maas, F. E.; Maggiora, M.; Malik, Q. A.; Mao, Y. J.; Mao, Z. P.; Marcello, S.; Messchendorp, J. G.; Mezzadri, G.; Min, J.; Min, T. J.; Mitchell, R. E.; Mo, X. H.; Mo, Y. J.; Morales Morales, C.; Muchnoi, N. Yu.; Muramatsu, H.; Musiol, P.; Nefedov, Y.; Nerling, F.; Nikolaev, I. B.; Ning, Z.; Nisar, S.; Niu, S. L.; Niu, X. Y.; Olsen, S. L.; Ouyang, Q.; Pacetti, S.; Pan, Y.; Patteri, P.; Pelizaeus, M.; Peng, H. P.; Peters, K.; Pettersson, J.; Ping, J. L.; Ping, R. G.; Poling, R.; Prasad, V.; Qi, H. R.; Qi, M.; Qian, S.; Qiao, C. F.; Qin, L. Q.; Qin, N.; Qin, X. S.; Qin, Z. H.; Qiu, J. F.; Rashid, K. H.; Redmer, C. F.; Ripka, M.; Rong, G.; Rosner, Ch.; Ruan, X. D.; Sarantsev, A.; Savrié, M.; Schnier, C.; Schoenning, K.; Shan, W.; Shao, M.; Shen, C. P.; Shen, P. X.; Shen, X. Y.; Sheng, H. Y.; Song, W. M.; Song, X. Y.; Sosio, S.; Spataro, S.; Sun, G. X.; Sun, J. F.; Sun, S. S.; Sun, X. H.; Sun, Y. J.; Sun, Y. Z.; Sun, Z. J.; Sun, Z. T.; Tang, C. J.; Tang, X.; Tapan, I.; Thorndike, E. H.; Tiemens, M.; Uman, I.; Varner, G. S.; Wang, B.; Wang, B. L.; Wang, D.; Wang, D. Y.; Wang, K.; Wang, L. L.; Wang, L. S.; Wang, M.; Wang, P.; Wang, P. L.; Wang, W.; Wang, W. P.; Wang, X. F.; Wang, Y.; Wang, Y. D.; Wang, Y. F.; Wang, Y. Q.; Wang, Z.; Wang, Z. G.; Wang, Z. H.; Wang, Z. Y.; Wang, Z. Y.; Weber, T.; Wei, D. H.; Weidenkaff, P.; Wen, S. P.; Wiedner, U.; Wolke, M.; Wu, L. H.; Wu, L. J.; Wu, Z.; Xia, L.; Xia, L. G.; Xia, Y.; Xiao, D.; Xiao, H.; Xiao, Z. J.; Xie, Y. G.; Xie, Y. H.; Xiu, Q. L.; Xu, G. F.; Xu, J. J.; Xu, L.; Xu, Q. J.; Xu, Q. N.; Xu, X. P.; Yan, L.; Yan, W. B.; Yan, W. C.; Yan, Y. H.; Yang, H. J.; Yang, H. X.; Yang, L.; Yang, Y. X.; Ye, M.; Ye, M. H.; Yin, J. H.; You, Z. Y.; Yu, B. X.; Yu, C. X.; Yu, J. S.; Yuan, C. Z.; Yuan, Y.; Yuncu, A.; Zafar, A. A.; Zeng, Y.; Zeng, Z.; Zhang, B. X.; Zhang, B. Y.; Zhang, C. C.; Zhang, D. H.; Zhang, H. H.; Zhang, H. Y.; Zhang, J.; Zhang, J. J.; Zhang, J. L.; Zhang, J. Q.; Zhang, J. W.; Zhang, J. Y.; Zhang, J. Z.; Zhang, K.; Zhang, L.; Zhang, S. Q.; Zhang, X. Y.; Zhang, Y.; Zhang, Y.; Zhang, Y. H.; Zhang, Y. N.; Zhang, Y. T.; Zhang, Yu; Zhang, Z. H.; Zhang, Z. P.; Zhang, Z. Y.; Zhao, G.; Zhao, J. W.; Zhao, J. Y.; Zhao, J. Z.; Zhao, Lei; Zhao, Ling; Zhao, M. G.; Zhao, Q.; Zhao, Q. W.; Zhao, S. J.; Zhao, T. C.; Zhao, Y. B.; Zhao, Z. G.; Zhemchugov, A.; Zheng, B.; Zheng, J. P.; Zheng, W. J.; Zheng, Y. H.; Zhong, B.; Zhou, L.; Zhou, X.; Zhou, X. K.; Zhou, X. R.; Zhou, X. Y.; Zhu, K.; Zhu, K. J.; Zhu, S.; Zhu, S. H.; Zhu, X. L.; Zhu, Y. C.; Zhu, Y. S.; Zhu, Z. A.; Zhuang, J.; Zotti, L.; Zou, B. S.; Zou, J. H.; BESIII Collaboration

2017-06-01

By analyzing the large-angle Bhabha scattering events e+e- → (γ)e+e- and diphoton events e+e- → (γ)γγ for the data sets collected at center-of-mass (c.m.) energies between 2.2324 and 4.5900 GeV (131 energy points in total) with the upgraded Beijing Spectrometer (BESIII) at the Beijing Electron-Positron Collider (BEPCII), the integrated luminosities have been measured at the different c.m. energies, individually. The results are important inputs for the R value and J/ψ resonance parameter measurements. Supported by National Key Basic Research Program of China (2015CB856700), National Natural Science Foundation of China (NSFC) (10935007, 11121092, 11125525, 11235011, 11322544, 11335008, 11375170, 11275189, 11079030, 11475164, 11475169, 11005109, 10979095, 11275211), Chinese Academy of Sciences (CAS) Large-Scale Scientific Facility Program; Joint Large-Scale Scientific Facility Funds of the NSFC and CAS (11179007, U1232201, U1332201, U1532102). (KJCX2-YW-N29, KJCX2-YW-N45). 100 Talents Program of CAS, INPAC and Shanghai Key Laboratory for Particle Physics and Cosmology, German Research Foundation DFG (Collaborative Research Center CRC-1044), Istituto Nazionale di Fisica Nucleare, Italy, Ministry of Development of Turkey (DPT2006K-120470), Russian Foundation for Basic Research (14-07-91152), U. S. Department of Energy (DE-FG02-04ER41291, DE-FG02-05ER41374, DE-FG02-94ER40823, DESC0010118), U.S. National Science Foundation, University of Groningen (RuG) and the Helmholtzzentrum fuer Schwerionenforschung GmbH (GSI), Darmstadt, WCU Program of National Research Foundation of Korea (R32-2008-000-10155-0)

The Comparison between Teacher Centered and Student Centered Educational Methods

Directory of Open Access Journals (Sweden)

M Anvar

2009-02-01

Full Text Available Background and Purpose: Various approaches to learning are suggested & practiced. The traditional medical education were more teacher centered oriented . In this method the students’ involvement in the process of learning is not remarkable, but the new approach to medical education supports the students involvement. This study evaluated the various method of lecturing considering students involvements.Methods: One hundred two first year medical and nursing students involved in this study and their opinion about these two methods of learning were obtained by filling of a questionnaire. The subject of the lectures was “general psychology” which was carried out 50% by the students and 50% by the teacher. The statistical analysis was carried out by SPSS program.Results: Considering students opinion in student-centered method the various aspect of learning such as mutual understanding, use of textbooks and references were significantly increased , whereasother aspects of learning such as self esteem, study time, innovation, and study attitude though were improved, but were not significant as compared with teacher centered method. In teacher-centeredmethod the understanding of the subjects was significantly increased .Other aspects of learning such as motivation and concentration were improved but not significantly as compared with studentcentered method.Conclusion: As the result showed student centered method was favored in several aspects of learning while in teacher centered method only understanding of the subject was better . Careful choice of teaching method to provide a comprehensive learning experience should take into account these differences.Key words: TEACHER CENTERED, STUDENT CENTERED, LEARNING

Isothermal (vapour + liquid) equilibrium for the binary {l_brace}1,1,2,2-tetrafluoroethane (R134) + propane (R290){r_brace} and {l_brace}1,1,2,2-tetrafluoroethane (R134) + isobutane (R600a){r_brace} systems

Energy Technology Data Exchange (ETDEWEB)

Dong Xueqiang [Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, P.O. Box 2711, Beijing 100190 (China); Graduate University of Chinese Academy of Sciences, Beijing 100039 (China); Gong Maoqiong, E-mail: gongmq@mail.ipc.ac.c [Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, P.O. Box 2711, Beijing 100190 (China); Liu Junsheng [Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, P.O. Box 2711, Beijing 100190 (China); Graduate University of Chinese Academy of Sciences, Beijing 100039 (China); Wu Jianfeng, E-mail: jfwu@mail.ipc.ac.c [Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, P.O. Box 2711, Beijing 100190 (China)

2010-09-15

(Vapour + liquid) equilibrium (VLE) data for the binary systems of {l_brace}1,1,2,2-tetrafluoroethane (R134) + propane (R290){r_brace} and {l_brace}1,1,2,2-tetrafluoroethane (R134) + isobutane (R600a){r_brace} were measured with a recirculation method at the temperatures ranging from (263.15 to 278.15) K and (268.15 to 288.15) K, respectively. All of the data were correlated by the Peng-Robinson (PR) equation of state (EoS) with the Huron-Vidal (HV) mixing rules utilizing the non-random two-liquid (NRTL) activity coefficient model. Good agreement can be found between the experimental data and the correlated results. Azeotropic behaviour can be found at the measured temperature ranges for these two mixtures.

[Escitalopram and citalopram: the unexpected role of the R-enantiomer].

Science.gov (United States)

Jacquot, C; David, D J; Gardier, A M; Sánchez, C

2007-01-01

Citalopram, a selective serotonin reuptake inhibitor, is composed of 2 enantiomers, R-citalopram and S-citalopram, 2 different non-superimposable mirror image forms of the same molecule. Separating these 2 enantiomers has enabled studying their individual properties. Citalopram's pharmacologic activity is centered on the S enantiomer's high affinity for the serotonin transporter which is twice as high as citalopram's and 30 to 40 times higher than R-citalopram. This leads to an inhibition of serotonin reuptake two times higher for escitalopram compared with citalopram and confirms that citalopram's pharmacologic activity is due to the S-enantiomer. Contrary to what might be expected, the effect of escitalopram (DCI of S-citalopram) is not superimposable on an equivalent dose of citalopram but is superior. Several hypotheses could explain this superiority. First, conversions of the S-enantiomer into the R-enantiomer may occur, but there is no reason why this phenomenon would happen more when both enantiomers are present than when escitalopram is alone. Furthermore, pharmacokinetic studies have shown that S or R configurations are stable in vivo. Second, a particular action of R-citalopram may influence the S-enantiomer's kinetic from intestinal absorption to blood-brain barrier. But concentrations of both enantiomers in the frontal cortex are the same. Therefore, R-citalopram does not interfere with escitalopram's kinetic. Finally, interactions may appear at the synaptic level. Results of experimentation, after in situ injection to the cortex level, confirm that an interaction between the 2 enantiomers takes place at that level. A direct negative interaction of R-citalopram on one or several effectors that create the antidepressive effect seems justified. This negative interaction has been studied in depth. Animal models have shown that the R-enantiomer has no antidepressive potential and when associated with escitalopram prohedonic effects disappear. Escitalopram

Building a SuAVE browse interface to R2R's Linked Data

Science.gov (United States)

Clark, D.; Stocks, K. I.; Arko, R. A.; Zaslavsky, I.; Whitenack, T.

2017-12-01

The Rolling Deck to Repository program (R2R) is creating and evaluating a new browse portal based on the SuAVE platform and the R2R linked data graph. R2R manages the underway sensor data collected by the fleet of US academic research vessels, and provides a discovery and access point to those data at its website, www.rvdata.us. R2R has a database-driven search interface, but seeks a more capable and extensible browse interface that could be built off of the substantial R2R linked data resources. R2R's Linked Data graph organizes its data holdings around key concepts (e.g. cruise, vessel, device type, operator, award, organization, publication), anchored by persistent identifiers where feasible. The "Survey Analysis via Visual Exploration" or SuAVE platform (suave.sdsc.edu) is a system for online publication, sharing, and analysis of images and metadata. It has been implemented as an interface to diverse data collections, but has not been driven off of linked data in the past. SuAVE supports several features of interest to R2R, including faceted searching, collaborative annotations, efficient subsetting, Google maps-like navigation over an image gallery, and several types of data analysis. Our initial SuAVE-based implementation was through a CSV export from the R2R PostGIS-enabled PostgreSQL database. This served to demonstrate the utility of SuAVE but was static and required reloading as R2R data holdings grew. We are now working to implement a SPARQL-based ("RDF Query Language") service that directly leverages the R2R Linked Data graph and offers the ability to subset and/or customize output.We will show examples of SuAVE faceted searches on R2R linked data concepts, and discuss our experience to date with this work in progress.

The status of the LANSCE refurbishment project (LANSCE-R)

International Nuclear Information System (INIS)

Erickson, John Leonard; Jones, Kevin; Streve, Michael

2008-01-01

The Los Alamos Neutron Science Center (LANSCE) accelerator is an 800-MeV proton linac that drives user facilities for isotope production, proton radiography, ultra-cold neutrons, weapons neutron research and various sciences using neutron scattering. The LANSCE Refurbishment Project (LANSCE-R) is an ambitious project to refurbish key elements of the LANSCE accelerator that are becoming obsolete or nearing end-of-life. The conceptual design phase for the project is funded and underway. The 5 year, $170M (US) project will enable future decades of reliable, high-performance operation. It will replace a substantial fraction of the radio-frequency power systems (gridded tubes and klystrons) with modern systems, completely refurbish the original accelerator control and timing systems, replace obsolete diagnostic devices, and modernize other ancillary systems. An overview of the LANSCE-R project will be presented. The functional and operating requirements will be discussed, the proposed technical solutions presented, and the plan for successful project execution while meeting annual customer expectations for beam delivery will be reviewed.

Analytical modeling of threshold voltage for Cylindrical Gate All Around (CGAA MOSFET using center potential

Directory of Open Access Journals (Sweden)

K.P. Pradhan

2015-12-01

Full Text Available In this paper, an analytical threshold voltage model is proposed for a cylindrical gate-all-around (CGAA MOSFET by solving the 2-D Poisson’s equation in the cylindrical coordinate system. A comparison is made for both the center and the surface potential model of CGAA MOSFET. This paper claims that the calculation of threshold voltage using center potential is more accurate rather than the calculation from surface potential. The effects of the device parameters like the drain bias (VDS, oxide thickness (tox, channel thickness (r, etc., on the threshold voltage are also studied in this paper. The model is verified with 3D numerical device simulator Sentaurus from Synopsys Inc.

A comparison of R-22, R-134a, R-410a, and R-407c condensation performance in smooth and enhanced tubes: Part 2, Pressure drop

Energy Technology Data Exchange (ETDEWEB)

Eckels, S J; Tesene, B A

1999-07-01

This paper reports pressure drops during condensation for R-22, R-134a, R-410a, and R-407c in three enhanced tubes and one smooth tube. The test tubes were a 3/8 inch outer diameter smooth tube, a 3/8 inch outer diameter microfin tube, a 5/16 inch outer diameter microfin tube, and a 5/8 inch outer diameter microfin tube. Pressure drops are reported at four mass fluxes, at two saturation temperatures, and over a range of average qualities in the test tubes. The pressure drops for R-410a were approximately 40% lower than those of R-22 in both tubes. R-407c had 10% to 20% lower pressure drops than R-22, while 134-a had slightly larger pressure drops than R-22. The microfin tube pressure drops were, on average, 40% to 80% higher than those for the smooth tube for all refrigerants. The pressure drop penalty of the microfin tube was shown to decrease with increased quality.

R

Directory of Open Access Journals (Sweden)

Prokop Jacek

2015-06-01

Full Text Available This paper analyzes the impact of R&D activities in an oligopoly on consumer surplus and social welfare. We use a two-stage model to analyze the behavior of duopolists at the research level, and in the final-product market, under the assumption of linear and quadratic cost functions. Three options for firm competition are considered: 1 Cournot competition at both stages; 2 cooperation at the R&D stage and Cournot competition in the final-product market; and 3 cooperation at both stages. Numerical simulations for various levels of R&D spillovers are conducted to analyze the welfare effects of firm decisions. We conclude that for high levels of technological spillovers, total welfare is highest when firms engage in cooperation at the R&D stage, and compete in the final product market, independent of the shape of cost functions. However, the functional form of production costs has a qualitative impact on welfare when firms fully compete.

On The Center Sets and Center Numbers of Some Graph Classes

OpenAIRE

R, Ram Kumar.; Balakrishnan, Kannan; Changat, Manoj; Sreekumar, A.; Narasimha-Shenoi, Prasanth G.

2013-01-01

For a set $S$ of vertices and the vertex $v$ in a connected graph $G$, $\\displaystyle\\max_{x \\in S}d(x,v)$ is called the $S$-eccentricity of $v$ in $G$. The set of vertices with minimum $S$-eccentricity is called the $S$-center of $G$. Any set $A$ of vertices of $G$ such that $A$ is an $S$-center for some set $S$ of vertices of $G$ is called a center set. We identify the center sets of certain classes of graphs namely, Block graphs, $K_{m,n}$, $K_n-e$, wheel graphs, odd cycles and symmetric e...

R Divakar

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. R Divakar. Articles written in Bulletin of Materials Science. Volume 36 Issue 7 December 2013 pp 1323-1329. Structural characterization of electrodeposited boron · Ashish Jain C Ghosh T R Ravindran S Anthonysamy R Divakar E Mohandas G S Gupta · More Details Abstract ...

R Gnanamoorthy

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science. R Gnanamoorthy. Articles written in Bulletin of Materials Science. Volume 25 Issue 2 April 2002 pp 109-114 Steels and Alloys. Fretting fatigue in AISI 1015 steel · R Gnanamoorthy R Rosi Reddy · More Details Abstract Fulltext PDF. A small osillatory movement between two ...

Status Report on the Development of Micro-Scheduling Software for the Advanced Outage Control Center Project

Energy Technology Data Exchange (ETDEWEB)

Germain, Shawn St. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Thomas, Kenneth [Idaho National Lab. (INL), Idaho Falls, ID (United States); Farris, Ronald [Idaho National Lab. (INL), Idaho Falls, ID (United States); Joe, Jeffrey [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2014-09-01

The long-term viability of existing nuclear power plants (NPPs) in the United States (U.S.) is dependent upon a number of factors, including maintaining high capacity factors, maintaining nuclear safety, and reducing operating costs, particularly those associated with refueling outages. Refueling outages typically take 20-30 days, and for existing light water NPPs in the U.S., the reactor cannot be in operation during the outage. Furthermore, given that many NPPs generate between $1-1.5 million/day in revenue when in operation, there is considerable interest in shortening the length of refueling outages. Yet, refueling outages are highly complex operations, involving multiple concurrent and dependent activities that are difficult to coordinate. Finding ways to improve refueling outage performance while maintaining nuclear safety has proven to be difficult. The Advanced Outage Control Center project is a research and development (R&D) demonstration activity under the Light Water Reactor Sustainability (LWRS) Program. LWRS is a R&D program which works with industry R&D programs to establish technical foundations for the licensing and managing of long-term, safe, and economical operation of current NPPs. The Advanced Outage Control Center project has the goal of improving the management of commercial NPP refueling outages. To accomplish this goal, this INL R&D project is developing an advanced outage control center (OCC) that is specifically designed to maximize the usefulness of communication and collaboration technologies for outage coordination and problem resolution activities. This report describes specific recent efforts to develop a capability called outage Micro-Scheduling. Micro-Scheduling is the ability to allocate and schedule outage support task resources on a sub-hour basis. Micro-Scheduling is the real-time fine-tuning of the outage schedule to react to the actual progress of the primary outage activities to ensure that support task resources are

Feed Materials Production Center waste management plan (Revision to NLCO-1100, R.6)

International Nuclear Information System (INIS)

Watts, R.E.; Allen, T.; Castle, S.A.; Hopper, J.P.; Oelrich, R.L.

1986-01-01

In the process of producing uranium metal products used in Department of Energy (DOE) defense programs at other DOE facilities, various types of wastes are generated at the Feed Materials Production Center (FMPC). Process wastes, both generated and stored, are discussed in the Waste Management Plan and include low-level radioactive waste (LLW), mixed hazardous/radioactive waste, and sanitary/industrial waste. Scrap metal waste and wastes requiring special remediation are also addressed in the Plan. The Waste Management Plan identifies the comprehensive programs developed to address safe storage and disposition of all wastes from past, present, and future operations at the FMPC. Waste streams discussed in this Plan are representative of the wastes generated and waste types that concern worker and public health and safety. Budgets and schedules for implementation of waste disposition are also addressed. The waste streams receiving the largest amount of funding include LLW approved for shipment by DOE/ORO to the Nevada Test Site (NTS) (MgF 2 , slag leach filter cake, and neutralized raffinate); remedial action wastes (waste pits, K-65 silo waste); thorium; scrap metal (contaminated and noncontaminated ferrous and copper scrap); construction rubble and soil generated from decontamination and decommissioning of outdated facilities; and low-level wastes that will be handled through the Low-Level Waste Processing and Shipping System (LLWPSS). Waste Management milestones are also provided. The Waste Management Plan is divided into eight major sections: Introduction; Site Waste and Waste Generating Process; Strategy; Projects and Operations; Waste Stream Budgets; Milestones; Quality Assurance for Waste Management; and Environmental Monitoring Program

Bituminization of radioactive wastes at the Nuclear Research Center Karlsruhe. Experience from plant operation and development work

Energy Technology Data Exchange (ETDEWEB)

Hild, W; Kluger, W; Krause, H

1976-05-01

A summary is given of the main operational experience gained at the Nuclear Research Center Karlsruhe in 4 years operation of the bituminization plant for evaporator concentrates from low- and medium level wastes. At the same time some of the essential results are compiled that have been obtained in the R + D activities on bituminization.

Center-Specific Factors Associated with Peritonitis Risk-A Multi-Center Registry Analysis.

Science.gov (United States)

Nadeau-Fredette, Annie-Claire; Johnson, David W; Hawley, Carmel M; Pascoe, Elaine M; Cho, Yeoungjee; Clayton, Philip A; Borlace, Monique; Badve, Sunil V; Sud, Kamal; Boudville, Neil; McDonald, Stephen P

♦ Previous studies have reported significant variation in peritonitis rates across dialysis centers. Limited evidence is available to explain this variability. The aim of this study was to assess center-level predictors of peritonitis and their relationship with peritonitis rate variations. ♦ All incident peritoneal dialysis (PD) patients treated in Australia between October 2003 and December 2013 were included. Data were accessed through the Australia and New Zealand Dialysis and Transplant Registry. The primary outcome was peritonitis rate, evaluated in a mixed effects negative binomial regression model. Peritonitis-free survival was assessed as a secondary outcome in a Cox proportional hazards model. ♦ Overall, 8,711 incident PD patients from 51 dialysis centers were included in the study. Center-level predictors of lower peritonitis rates included smaller center size, high proportion of PD, low peritoneal equilibration test use at PD start, and low proportion of hospitalization for peritonitis. In contrast, a low proportion of automated PD exposure, high icodextrin exposure and low or high use of antifungal prophylaxis at the time of peritonitis were associated with a higher peritonitis rate. Similar results were obtained for peritonitis-free survival. Overall, accounting for center-level characteristics appreciably decreased peritonitis variability among dialysis centers (p = 0.02). ♦ This study identified specific center-level characteristics associated with the variation in peritonitis risk. Whether these factors are directly related to peritonitis risk or surrogate markers for other center characteristics is uncertain and should be validated in further studies. Copyright © 2016 International Society for Peritoneal Dialysis.

Carbon Monoxide Information Center

Medline Plus

Full Text Available ... Education Safety Education Centers Carbon Monoxide Information Center Carbon Monoxide Information Center En Español The Invisible Killer Carbon monoxide, also known as CO, is called the " ...

Lepton accelerators and radiation sources: R and D investment at BNL

International Nuclear Information System (INIS)

Ben-Zvi, I.; Fernow, R.; Gallardo, J.; Hart, M.; Hastings, J.; Johnson, E.; Krinsky, S.; Palmer, R.; Yu, L.H.

1997-03-01

Brookhaven National Laboratory (BNL) has shown its determination to remain at the forefront of accelerator based science through its continued investment in long range accelerator R and D. The laboratory has a broad program in accelerator technology development including projects such as high T c magnets at RHIC, Siberian Snakes at the AGS, brightness upgrades on the NSLS storage ring, and spallation source R and D in several departments. This report focuses on a segment of the overall program: the lepton accelerator and coherent radiation source R and D at the laboratory. These efforts are aimed at (1) development of high brightness electron beams, (2) novel acceleration techniques, (3) seeded Free Electron Laser (FEL) development, and (4) R and D for a muon collider. To pursue these objectives, BNL ha over the past decade introduced new organizational arrangements. The BNL Center for Accelerator Physics (CAP) is an interdepartmental unit dedicated to promoting R and D which, cannot be readily conducted within the programs of operating facilities. The Accelerator Test Facility (ATF) is managed by CAP and NSLS as a user facility dedicated to accelerator and beam physics problems of interest to both the High Energy Physics and Basic Energy Sciences programs of the DOE. Capitalizing on these efforts, the Source Development Laboratory (SDL) was established by the NSLS to facilitate coordinated development of sources and experiments to produce and utilize coherent sub-picosecond synchrotron radiation. This White Paper describes the programs being pursued at CAP, ATF and SDL aimed at advancing basic knowledge of lepton accelerators and picosecond radiation sources

Stability of the Einstein static universe in f(R, T) gravity

Energy Technology Data Exchange (ETDEWEB)

Shabani, Hamid [University of Sistan and Baluchestan, Physics Department, Faculty of Sciences, Zahedan (Iran, Islamic Republic of); Ziaie, Amir Hadi [Kahnooj Branch, Islamic Azad University, Department of Physics, Kerman (Iran, Islamic Republic of)

2017-01-15

The Einstein static (ES) universe has played a major role in various emergent scenarios recently proposed in order to cure the problem of the initial singularity of the standard model of cosmology. In the model we address, we study the existence and stability of an ES universe in the context of f(R, T) modified theories of gravity. Considering specific forms of the f(R, T) function, we seek for the existence of solutions representing ES state. Using dynamical system techniques along with numerical analysis, we find two classes of solutions: the first one is always unstable of the saddle type, while the second is always stable so that its dynamical behavior corresponds to a center equilibrium point. The importance of the second class of solutions is due to the significant role they play in constructing non-singular emergent models in which the universe could have experienced past-eternally a series of infinite oscillations about such an initial static state after which it enters, through a suitable physical mechanism, to an inflationary era. Considering specific forms for the functionality of f(R, T), we show that this theory is capable of providing cosmological solutions which admit emergent universe (EU) scenarios. We also investigate homogeneous scalar perturbations for the mentioned models. The stability regions of the solutions are parametrized by a linear equation of state (EoS) parameter and other free parameters that will be introduced for the models. Our results suggest that modifications in f(R, T) gravity would lead to stable solutions which are unstable in f(R) gravity model. (orig.)

Stability of the Einstein static universe in f(R, T) gravity

International Nuclear Information System (INIS)

Shabani, Hamid; Ziaie, Amir Hadi

2017-01-01

The Einstein static (ES) universe has played a major role in various emergent scenarios recently proposed in order to cure the problem of the initial singularity of the standard model of cosmology. In the model we address, we study the existence and stability of an ES universe in the context of f(R, T) modified theories of gravity. Considering specific forms of the f(R, T) function, we seek for the existence of solutions representing ES state. Using dynamical system techniques along with numerical analysis, we find two classes of solutions: the first one is always unstable of the saddle type, while the second is always stable so that its dynamical behavior corresponds to a center equilibrium point. The importance of the second class of solutions is due to the significant role they play in constructing non-singular emergent models in which the universe could have experienced past-eternally a series of infinite oscillations about such an initial static state after which it enters, through a suitable physical mechanism, to an inflationary era. Considering specific forms for the functionality of f(R, T), we show that this theory is capable of providing cosmological solutions which admit emergent universe (EU) scenarios. We also investigate homogeneous scalar perturbations for the mentioned models. The stability regions of the solutions are parametrized by a linear equation of state (EoS) parameter and other free parameters that will be introduced for the models. Our results suggest that modifications in f(R, T) gravity would lead to stable solutions which are unstable in f(R) gravity model. (orig.)

Development of Capacity Building Training Programs for Nuclear R and D Personnel

International Nuclear Information System (INIS)

Lee, Eui Jin; Nam, Youngmi; Hwang, Hyeseon; Jang, Eunsook; Song, Eun Ju

2016-01-01

The Nuclear Training and Education Center of the Korea Atomic Energy Research Institute has been operating technical training courses on nuclear engineering, engineering mathematics, management leadership training, out sourced practical training, legal education, etc. Strengthening nuclear R and D capacity is essential for the long-term mission and goals of the institute. Therefore, it requires a comprehensive training program to strengthen the unique capability of the institute that reflects diversity and differentiation. In this regard, the capacity building training program has developed on a modular basis, and the developed training program should be tailored to operate according to the institute needs. The capacity building training program for nuclear R and D personnel was developed to reflect the technology strengths of the institute. The developed training program will be developed into a leading branded education of the institute in the future

Development of Capacity Building Training Programs for Nuclear R and D Personnel

Energy Technology Data Exchange (ETDEWEB)

Lee, Eui Jin; Nam, Youngmi; Hwang, Hyeseon; Jang, Eunsook; Song, Eun Ju [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-10-15

The Nuclear Training and Education Center of the Korea Atomic Energy Research Institute has been operating technical training courses on nuclear engineering, engineering mathematics, management leadership training, out sourced practical training, legal education, etc. Strengthening nuclear R and D capacity is essential for the long-term mission and goals of the institute. Therefore, it requires a comprehensive training program to strengthen the unique capability of the institute that reflects diversity and differentiation. In this regard, the capacity building training program has developed on a modular basis, and the developed training program should be tailored to operate according to the institute needs. The capacity building training program for nuclear R and D personnel was developed to reflect the technology strengths of the institute. The developed training program will be developed into a leading branded education of the institute in the future.

Parallel R

CERN Document Server

McCallum, Ethan

2011-01-01

It's tough to argue with R as a high-quality, cross-platform, open source statistical software product-unless you're in the business of crunching Big Data. This concise book introduces you to several strategies for using R to analyze large datasets. You'll learn the basics of Snow, Multicore, Parallel, and some Hadoop-related tools, including how to find them, how to use them, when they work well, and when they don't. With these packages, you can overcome R's single-threaded nature by spreading work across multiple CPUs, or offloading work to multiple machines to address R's memory barrier.

Dependence and physical exercise: Spanish validation of the Exercise Dependence Scale-Revised (EDS-R).

Science.gov (United States)

Sicilia, Alvaro; González-Cutre, David

2011-05-01

The purpose of this study was to validate the Spanish version of the Exercise Dependence Scale-Revised (EDS-R). To achieve this goal, a sample of 531 sport center users was used and the psychometric properties of the EDS-R were examined through different analyses. The results supported both the first-order seven-factor model and the higher-order model (seven first-order factors and one second-order factor). The structure of both models was invariant across age. Correlations among the subscales indicated a related factor model, supporting construct validity of the scale. Alpha values over .70 (except for Reduction in Other Activities) and suitable levels of temporal stability were obtained. Users practicing more than three days per week had higher scores in all subscales than the group practicing with a frequency of three days or fewer. The findings of this study provided reliability and validity for the EDS-R in a Spanish context.

Electron microscopic in situ hybridization and autoradiography: Localization and transcription of rDNA in human lymphocyte nucleoli

International Nuclear Information System (INIS)

Wachtler, F.; Mosgoeller, W.S.; Schwarzacher, H.G.

1990-01-01

The distribution of ribosomal DNA (rDNA) in the nucleoli of human lymphocytes was revealed by in situ hybridization with a nonautoradiographic procedure at the electron microscopic level. rDNA is located in the dense fibrillar component of the nucleolus but not in the fibrillar centers. In the same cells the incorporation of tritiated uridine takes place in the dense fibrillar component of the nucleolus as seen by autoradiography followed by gold latensification. From these findings it can be concluded that the transcription of ribosomal DNA takes place in the dense fibrillar component of the nucleolus

Når dataindsamlingen går online

DEFF Research Database (Denmark)

Larsen, Malene Charlotte

2012-01-01

Internettet er i dag blevet essentielt for mange forskere; både som forskningsobjekt, dataindsamlings-værktøj, kommunikationsplatform, samlingssted eller publiceringskanal. I dette kapitel skal vi se på, hvad der sker, når dataindsamlingen går online, og vi studerer internetbaserede praksisser...

Development of a EUV Test Facility at the Marshall Space Flight Center

Science.gov (United States)

West, Edward; Pavelitz, Steve; Kobayashi, Ken; Robinson, Brian; Cirtain, Johnathan; Gaskin, Jessica; Winebarger, Amy

2011-01-01

This paper will describe a new EUV test facility that is being developed at the Marshall Space Flight Center (MSFC) to test EUV telescopes. Two flight programs, HiC - high resolution coronal imager (sounding rocket) and SUVI - Solar Ultraviolet Imager (GOES-R), set the requirements for this new facility. This paper will discuss those requirements, the EUV source characteristics, the wavelength resolution that is expected and the vacuum chambers (Stray Light Facility, Xray Calibration Facility and the EUV test chamber) where this facility will be used.

Womens Business Center

Data.gov (United States)

Small Business Administration — Women's Business Centers (WBCs) represent a national network of nearly 100 educational centers throughout the United States and its territories, which are designed...

Acoplamiento molecular y actividad antibacteriana de las tioureas (R,R-N,N´-bis(1-ciclohexiletiltiourea y (R,R-N,N´-bis(1-feniletiltiourea

Directory of Open Access Journals (Sweden)

Fabían Martínez Flores

2013-05-01

Full Text Available Las tioureas, son compuestos resultantes de sustituir el átomo de oxígeno de la urea (NH2CONH2 por un átomo de azufre (NH2CSNH2. Actualmente se ha visto que las tioureas presentan diversas actividades biológicas, dentro de las que se encuentra la antimicrobiana. En el presente estudio se evaluó la actividad antibacteriana mediante acoplamiento molecular entre la enzima DNA girasa (receptor y las tioureas (R, R-N,N´-bis(1 ciclohexiletiltiourea (CYTU1 y (R,R-N,N´-bis(1-feniletiltiourea (CYTU2 como ligando en busca del posible mecanismo de acción de estos compuestos, los resultados muestran que existe interacción entre la enzima y ambas tioureas en el sitio activo. Por otro lado, también se evaluó la actividad antibacteriana frente a cepas de Sthapylococcus aureus, Escherichia coli y Pseudomonas fluorescens, mediante el método de microdilución en caldo con la adición de bromuro de 3-(4,5-dimetil-2-tiazolil-2,5-difeniltetrazolium (MTT, como parte del ensayo de viabilidad, mostrando una disminución de la misma sólo contra las bacterias gram negativas, siendo la tiourea CYTU2 la que mostró mejor actividad antibacteriana. Molecular docking and antibacterial activity thioureas (R,R-N,N´-bis(1-cyclohexyethylthiourea and (R,R-N,N´-bis(1-phenylethylthiourea Abstract Thioureas are resultant compounds of substitute the oxygen atom from urea (NH2CONH2 for a sulfur atom (NH2CSNH2. There are evidential that show the biological activity of thioureas, within which are antibacterial activity. We studied the antibacterial activity of two thioureas (R,R-N,N´-bis(1 cyclohexylethylthiourea (CYTU1 y (R,R-N,N´-bis(1 phenylethylthiourea (CYTU2 in silico using Molecular Docking between the DNA gyrase enzyme (receptor and the two thioureas (ligand. The results showed interaction between DNA girase and both thioureas on the pocket of the enzyme. By other hand, the biological activity was evaluated against the following bacterial strains: Sthapylococcus

Investigating the Relativistic Motion of the Stars Near the Supermassive Black Hole in the Galactic Center

Czech Academy of Sciences Publication Activity Database

Parsa, M.; Eckart, A.; Shahzamanian, B.; Karas, Vladimír; Zajaček, M.; Zensus, J. A.; Straubmeier, C.

2017-01-01

Roč. 845, č. 1 (2017), 22/1-22/19 ISSN 0004-637X R&D Projects: GA MŠk(CZ) 7E13012 EU Projects: European Commission(XE) 312789 - STRONGGRAVITY Institutional support: RVO:67985815 Keywords : :astrometry * black hole physics * galactic center Subject RIV: BN - Astronomy, Celestial Mechanics, Astrophysics OBOR OECD: Astronomy (including astrophysics,space science) Impact factor: 5.533, year: 2016

R2R-printed inverted OPV modules - towards arbitrary patterned designs

Science.gov (United States)

Välimäki, M.; Apilo, P.; Po, R.; Jansson, E.; Bernardi, A.; Ylikunnari, M.; Vilkman, M.; Corso, G.; Puustinen, J.; Tuominen, J.; Hast, J.

2015-05-01

We describe the fabrication of roll-to-roll (R2R) printed organic photovoltaic (OPV) modules using gravure printing and rotary screen-printing processes. These two-dimensional printing techniques are differentiating factors from coated OPVs enabling the direct patterning of arbitrarily shaped and sized features into visual shapes and, increasing the freedom to connect the cells in modules. The inverted OPV structures comprise five layers that are either printed or patterned in an R2R printing process. We examined the rheological properties of the inks used and their relationship with the printability, the compatibility between the processed inks, and the morphology of the R2R-printed layers. We also evaluate the dimensional accuracy of the printed pattern, which is an important consideration in designing arbitrarily-shaped OPV structures. The photoactive layer and top electrode exhibited excellent cross-dimensional accuracy corresponding to the designed width. The transparent electron transport layer extended 300 µm beyond the designed values, whereas the hole transport layer shrank 100 µm. We also examined the repeatability of the R2R fabrication process when the active area of the module varied from 32.2 cm2 to 96.5 cm2. A thorough layer-by-layer optimization of the R2R printing processes resulted in realization of R2R-printed 96.5 cm2 sized modules with a maximum power conversion efficiency of 2.1% (mean 1.8%) processed with high functionality.

Influence of socioeconomic status on trauma center performance evaluations in a Canadian trauma system.

Science.gov (United States)

Moore, Lynne; Turgeon, Alexis F; Sirois, Marie-Josée; Murat, Valérie; Lavoie, André

2011-09-01

Trauma center performance evaluations generally include adjustment for injury severity, age, and comorbidity. However, disparities across trauma centers may be due to other differences in source populations that are not accounted for, such as socioeconomic status (SES). We aimed to evaluate whether SES influences trauma center performance evaluations in an inclusive trauma system with universal access to health care. The study was based on data collected between 1999 and 2006 in a Canadian trauma system. Patient SES was quantified using an ecologic index of social and material deprivation. Performance evaluations were based on mortality adjusted using the Trauma Risk Adjustment Model. Agreement between performance results with and without additional adjustment for SES was evaluated with correlation coefficients. The study sample comprised a total of 71,784 patients from 48 trauma centers, including 3,828 deaths within 30 days (4.5%) and 5,549 deaths within 6 months (7.7%). The proportion of patients in the highest quintile of social and material deprivation varied from 3% to 43% and from 11% to 90% across hospitals, respectively. The correlation between performance results with or without adjustment for SES was almost perfect (r = 0.997; 95% CI 0.995-0.998) and the same hospital outliers were identified. We observed an important variation in SES across trauma centers but no change in risk-adjusted mortality estimates when SES was added to adjustment models. Results suggest that after adjustment for injury severity, age, comorbidity, and transfer status, disparities in SES across trauma center source populations do not influence trauma center performance evaluations in a system offering universal health coverage. Copyright © 2011 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

Self-Access Centers: Maximizing Learners’ Access to Center Resources

Directory of Open Access Journals (Sweden)

Mark W. Tanner

2010-09-01

Full Text Available Originally published in TESL-EJ March 2009, Volume 12, Number 4 (http://tesl-ej.org/ej48/a2.html. Reprinted with permission from the authors.Although some students have discovered how to use self-access centers effectively, the majority appear to be unaware of available resources. A website and database of materials were created to help students locate materials and use the Self-Access Study Center (SASC at Brigham Young University’s English Language Center (ELC more effectively. Students took two surveys regarding their use of the SASC. The first survey was given before the website and database were made available. A second survey was administered 12 weeks after students had been introduced to the resource. An analysis of the data shows that students tend to use SASC resources more autonomously as a result of having a web-based database. The survey results suggest that SAC managers can encourage more autonomous use of center materials by provided a website and database to help students find appropriate materials to use to learn English.

78 FR 14549 - National Contact Center; Information Collection; National Contact Center Customer Evaluation Survey

Science.gov (United States)

2013-03-06

...] National Contact Center; Information Collection; National Contact Center Customer Evaluation Survey AGENCY... National Contact Center customer evaluation surveys. In this request, the previously approved surveys have... several months. These temporary surveys will allow the National Contact Center to compare its customer...

Efficacy and safety of low-dose valganciclovir for prevention of cytomegalovirus disease in renal transplant recipients: a single-center, retrospective analysis.

Science.gov (United States)

Gabardi, Steven; Magee, Colm C; Baroletti, Steven A; Powelson, John A; Cina, Jennifer L; Chandraker, Anil K

2004-10-01

To evaluate the safety and efficacy of valganciclovir 450 mg/day for 6 months for cytomegalovirus (CMV) prophylaxis in renal transplant recipients. Single-center, retrospective analysis. Urban, academic medical center. Fifty-eight patients who received de novo renal transplants from August 1, 2001-November 21, 2002. Valganciclovir 450 mg/day was administered to all renal transplant recipients at risk for CMV disease. Therapy was begun postoperatively and was dose adjusted to renal function. Data collected from renal transplant recipients were demographics, immunosuppressive and antiviral drug therapy, and occurrence of CMV disease, acute rejection, allograft loss, and hematologic adverse events. Donor (D)/recipient (R) CMV serostatus was 37.9% D+/R+, 29.3% D-/R+, 17.3% D+/R-, and 15.5% D-/R-. Antithymocyte globulin (ATG) was administered to 62.1% of patients. Most of the transplant recipients received triple immunosuppression as maintenance therapy. Median follow-up was 20 months. The frequency of CMV disease was 1.7% within 6 months after transplantation and 5.2% at any point after transplantation. All patients who developed CMV disease were D+/R- and had received ATG. Leukopenia and thrombocytopenia associated with valganciclovir were seen in 28% and 24% of patients, respectively. One patient developed acute cellular rejection. No graft losses or deaths occurred. Early discontinuation of valganciclovir occurred in 20% of patients secondary to severe, persistent leukopenia, thrombocytopenia, and/or diarrhea. None of these patients developed CMV disease. A high rate of CMV disease was noted among the D+/R- population. Administration of ATG as an induction agent also increased the frequency of CMV disease. Despite the low dosage of valganciclovir, hematologic adverse events were common. However, valganciclovir, administered at 450 mg/day for 6 months, was effective and relatively safe for prophylaxis of CMV disease in renal transplant recipients.

MARYLAND ROBOTICS CENTER

Data.gov (United States)

Federal Laboratory Consortium — The Maryland Robotics Center is an interdisciplinary research center housed in the Institute for Systems Research (link is external)within the A. James Clark School...

NIH Clinical Centers

Data.gov (United States)

Federal Laboratory Consortium — The NIH Clinical Center consists of two main facilities: The Mark O. Hatfield Clinical Research Center, which opened in 2005, houses inpatient units, day hospitals,...

Föräldrars upplevelse av insatsen föräldrakoordinator.

OpenAIRE

Aspén-Franzén, Annika

2014-01-01

Föräldrakoordination är en barnfokuserad alternativ konfliktlösningsmetod som praktiserats i Sverige sedan 2009. Denna intervjustudie har undersökt separerade föräldrars upplevelse av att få stöd i sitt föräldrasamarbete av en föräldrakoordinator. Intervjuer har genomförts med sju föräldrar som haft insatsen föräldrakoordinator under minst sex månader. Samtliga deltagande föräldrar har flera års erfarenhet av svårlösta konflikter med den andra föräldern och har tidigare provat andra former av...

Hydrologic Engineering Center

Data.gov (United States)

Federal Laboratory Consortium — The Hydrologic Engineering Center (HEC), an organization within the Institute for Water Resources, is the designated Center of Expertise for the U.S. Army Corps of...

Computational geometry lectures at the morningside center of mathematics

CERN Document Server

Wang, Ren-Hong

2003-01-01

Computational geometry is a borderline subject related to pure and applied mathematics, computer science, and engineering. The book contains articles on various topics in computational geometry, which are based on invited lectures and some contributed papers presented by researchers working during the program on Computational Geometry at the Morningside Center of Mathematics of the Chinese Academy of Science. The opening article by R.-H. Wang gives a nice survey of various aspects of computational geometry, many of which are discussed in more detail in other papers in the volume. The topics include problems of optimal triangulation, splines, data interpolation, problems of curve and surface design, problems of shape control, quantum teleportation, and others.

A Measurement of $R = (\\sigma \\cdot B (p\\bar{p} \\to W^\\pm \\to e^\\pm \

Energy Technology Data Exchange (ETDEWEB)

Wahl, John Edward [Univ. of Chicago, IL (United States)

1999-01-01

We describe the analysis of data from the 1994-1995 collider run (1B) at the Fermi National Laboratory. We measure the ratio R= (σ x B(p$\\bar{p}$ → W → ev)/σ x B(p$\\bar{p}$ → Z → e⁺e^-, at a center of mass of √s = 1800 GeV.

Differentiating os acromiale from normally developing acromial ossification centers using magnetic resonance imaging

Energy Technology Data Exchange (ETDEWEB)

Winfeld, Matthew [Children' s National Medical Center, Department of Radiology, Washington, DC (United States); Rosenberg, Zehava Sadka; Wang, Annie; Bencardino, Jenny [New York University School of Medicine, New York, NY (United States)

2015-05-01

Acromial fusion may not be complete until age 18-25, making it questionable to diagnose os acromiale in adolescents. Os acromiale may exist in adolescents and can be differentiated from a developing acromial ossification center based on MRI findings. A total of 128 MRIs of the shoulder were randomly and blindly reviewed retrospectively by two musculoskeletal radiologists. The MRIs consisted of two groups: (1) 56 of os acromiale in adults (25-74 years old, mean, 50) and (2) 72 consecutive of adolescents (12-17 years old, mean, 14.5). The following were assessed at the interface between the distal acromion and os acromiale/developing ossification center(s): presence of os acromiale vs. developing acromion, orientation, margins, and edema within and adjacent to it. Fifty-one adults and 49 adolescents were included. Exclusions were due to poor image quality or confounding findings (n = 7) or complete acromial fusion (n = 21 adolescents). Utilizing accepted definitions of os acromiale, all adult cases (100 %) were accurately diagnosed as os acromiale, with transverse interface orientation and irregular margins (94 %, R = 0.86, p < 0.00001). Forty-five (92 %) adolescent cases were accurately diagnosed as normally developing acromion with arched interface and lobulated margins (92 %, R = 0.92, p < 0.000001). Four (8 %) adolescent cases were diagnosed as having os acromiale, with transverse orientation and irregular margins. Thirty-five (69 %) and 46 (90 %) adults had marrow and interface edema, respectively. Six (12 %) and eight (16 %) adolescents had marrow and interface edema, respectively, including the four concluded to be os acromiale. Adolescents may have imaging findings consistent with os acromiale. The diagnosis of os acromiale should be based on imaging features and not limited by age. (orig.)

Differentiating os acromiale from normally developing acromial ossification centers using magnetic resonance imaging

International Nuclear Information System (INIS)

Winfeld, Matthew; Rosenberg, Zehava Sadka; Wang, Annie; Bencardino, Jenny

2015-01-01

Acromial fusion may not be complete until age 18-25, making it questionable to diagnose os acromiale in adolescents. Os acromiale may exist in adolescents and can be differentiated from a developing acromial ossification center based on MRI findings. A total of 128 MRIs of the shoulder were randomly and blindly reviewed retrospectively by two musculoskeletal radiologists. The MRIs consisted of two groups: (1) 56 of os acromiale in adults (25-74 years old, mean, 50) and (2) 72 consecutive of adolescents (12-17 years old, mean, 14.5). The following were assessed at the interface between the distal acromion and os acromiale/developing ossification center(s): presence of os acromiale vs. developing acromion, orientation, margins, and edema within and adjacent to it. Fifty-one adults and 49 adolescents were included. Exclusions were due to poor image quality or confounding findings (n = 7) or complete acromial fusion (n = 21 adolescents). Utilizing accepted definitions of os acromiale, all adult cases (100 %) were accurately diagnosed as os acromiale, with transverse interface orientation and irregular margins (94 %, R = 0.86, p < 0.00001). Forty-five (92 %) adolescent cases were accurately diagnosed as normally developing acromion with arched interface and lobulated margins (92 %, R = 0.92, p < 0.000001). Four (8 %) adolescent cases were diagnosed as having os acromiale, with transverse orientation and irregular margins. Thirty-five (69 %) and 46 (90 %) adults had marrow and interface edema, respectively. Six (12 %) and eight (16 %) adolescents had marrow and interface edema, respectively, including the four concluded to be os acromiale. Adolescents may have imaging findings consistent with os acromiale. The diagnosis of os acromiale should be based on imaging features and not limited by age. (orig.)

Effectiveness of Client-centered Play Therapy on Fear and Anxiety in Preschool Children

Directory of Open Access Journals (Sweden)

Hoda Sadat Mosavi

2016-12-01

Full Text Available Background and Objective: Preschool period is playing main role in development and adjustment of children. Fear and anxiety are of externalizing disorders, providing untreated it leads to negative effects on individual and social relationship specially in adulthood therefore, this research investigates the influence of client-centered play therapy on fear and anxiety among preschool children (5-6 aged.Materials and Methods: This study is a quasi-experimental study with pre and post- tests. 14 male and female preschool children (5-6 aged who were obtaining scores higher than cut-off in Spence anxiety scale (SAS and fear survey schedule for children-revised (FSSC-R parents’ form questionnaires were selected, and then they were assigned randomly to the control and experimental groups. The experimental group received techniques of client-centered play therapy for six treatment sessions (45minutes for each session. The fear and anxiety were measured at the beginning and at end of therapeutic session, utilizing the Spence Children's Anxiety Scale and fear survey schedule for children-revised (FSSC-R parents’ form. Statistical analysis conducted by analysis of covariance (ANCOVA.Results: There is significantly difference in Mean (SD scores of pretest 130.4 (3.3 and posttest 127.1 (4.6 fear (P<0.001, F= 24.6 and in scores of pretest 58.6 (2.6 and post-test 48.28 (3.6 anxiety (P<0.001, F=19.5 between preschool children in pre and post-test.Conclusion: Findings indicated that client-centered play therapy has effective in reducing behavioral problem such as fear and anxiety disorders in preschool children. Therefore, it can be useful and applicable as the psychological therapeutic interventions for decreasing behavioral distress in children.

Expression profiling of miR-96, miR-584 and miR-422a in colon ...

African Journals Online (AJOL)

Purpose: To determine the correlation between miRNAs; miR-96, miR-422a and miR584, and colon cancer, and also to test whether any of these miRNAs can act as non-invasive biomarkers in colon cancer. Methods: The tumor samples and the corresponding normal mucosa used in this study were collected from 60 ...

Call Center Capacity Planning

DEFF Research Database (Denmark)

Nielsen, Thomas Bang

in order to relate the results to the service levels used in call centers. Furthermore, the generic nature of the approximation is demonstrated by applying it to a system incorporating a dynamic priority scheme. In the last paper Optimization of overflow policies in call centers, overflows between agent......The main topics of the thesis are theoretical and applied queueing theory within a call center setting. Call centers have in recent years become the main means of communication between customers and companies, and between citizens and public institutions. The extensively computerized infrastructure...... in modern call centers allows for a high level of customization, but also induces complicated operational processes. The size of the industry together with the complex and labor intensive nature of large call centers motivates the research carried out to understand the underlying processes. The customizable...

Carbon Monoxide Information Center

Medline Plus

Full Text Available ... Education Centers Carbon Monoxide Information Center Carbon Monoxide Information Center En Español The Invisible Killer Carbon monoxide, ... Install one and check its batteries regularly. View Information About CO Alarms Other CO Topics Safety Tips ...

Funding Opportunity: Genomic Data Centers

Science.gov (United States)

Funding Opportunity CCG, Funding Opportunity Center for Cancer Genomics, CCG, Center for Cancer Genomics, CCG RFA, Center for cancer genomics rfa, genomic data analysis network, genomic data analysis network centers,

R&D cooperation versus R&D subcontracting: empirical evidence from French survey data.

OpenAIRE

Estelle Dhont-Peltrault; Etienne Pfister

2007-01-01

This paper uses a survey of French firms active in R&D to identify the determinants of R&D outsourcing and of the ensuing trade-off between R&D subcontracting and R&D cooperation. Internal R&D expenditures increase both the probability of outsourcing and the number of R&D partners. Investment in fundamental R&D, group belonging, and the sector’s high R&D intensity positively influences the probability of R&D outsourcing but have less impact on the number of partners. R&D subcontracting is mor...

GAUGE R&R FOR AN OPTICAL MICROMETER INDUSTRIAL TYPE MACHINE

Directory of Open Access Journals (Sweden)

Georgia A. Louka

2010-12-01

Full Text Available The measurement of the uncertainty of a metric system, as 'Gauge R&R' and the collation of results between the Xbar & R and the ANOVA method, are extended in this essay. In an academic school laboratory we accomplished a sequence of measurements with the use of an Optical Micrometer Industrial Type Machine (MUL 300. This paper analyzes the measurement system that used in the laboratory and checks the reasons of the variability's provocation that observed in the machine, between the theoretical calculations and measurements. In order to find out this problem, we will use the 'Gage Repeatability and Reproducibility' technique of Measurement System Analysis (M.S.A.. This technique uses analysis of variance. In addition, will use Minitab program in order to find out the factors that we have in the whole experiment as enlarge the problem of measurements. In this paper, a statistical method using the correlation between Gage R&R and process capability indices is proposed for evaluating the adequacy of the acceptance criteria of P/T ratio. Finally, a comparative analysis has also been performed for evaluating the accuracy of Gage R&R between two methods (ANOVA and R- Xbar method. Hopefully, the results of this research can provide a useful reference for quality practitioners in various industries.

Day Care Centers

Data.gov (United States)

Department of Homeland Security — This database contains locations of day care centers for 50 states and Washington D.C. and Puerto Rico. The dataset only includes center based day care locations...

Evaluate Data Center Network Performance

DEFF Research Database (Denmark)

Pilimon, Artur

through a data center network, which is usually built with layer 2 switches and layer 3 routers. The topology of the data center network is crucial for latency in the data communication to and from the data center and between servers in the data center. Tests can be conducted to measure latency and other...... Engineering, scientists evaluate data center network topologies with an SDN-based (Software-Defined Networking) control framework measuring network performance – primarily latency. This can be used to plan data center scaling by testing how a new topology will function before changes are made. Data center...... performance parameters for different data center network topologies. It is however important that tests can be repeated and reproduced to have comparable information from the tests. There are, of course, many topologies that can be used for data center networks. At DTU Fotonik, Department of Photonics...

R quick syntax reference

CERN Document Server

Tollefson, Margot

2014-01-01

The R Quick Syntax Reference is a handy reference book detailing the intricacies of the R language. Not only is R a free, open-source tool, R is powerful, flexible, and has state of the art statistical techniques available. With the many details which must be correct when using any language, however, the R Quick Syntax Reference makes using R easier.Starting with the basic structure of R, the book takes you on a journey through the terminology used in R and the syntax required to make R work. You will find looking up the correct form for an expression quick and easy. With a copy of the R Quick

Center for Adaptive Optics | Center

Science.gov (United States)

Astronomy, UCSC's CfAO and ISEE, and Maui Community College, runs education and internship programs in / Jacobs Retina Center Department of Psychology University of California, San Francisco Department of University School of Optometry Maui Community College Maui Community College Space Grant Program Montana

A Study Investigating the Feasibility of Creating a Short Form of the WISC-R for Disabled Readers.

Science.gov (United States)

Brown, David M.; Otts, David A.

The purpose of this study was to investigate the feasibility of creating a short form of the Wechsler Intelligence Scale for Children-Revised (WISC-R) for use in a clinical setting with disabled readers. The subjects were 100 clients ages six to sixteen of the Belser-Parton Reading Center at the University of Alabama whose files contained scores…

Deep crustal melt plumbing of Bárðarbunga volcano, Iceland

Science.gov (United States)

Hudson, T. S.; White, R. S.; Greenfield, T.; Ágústsdóttir, T.; Brisbourne, A.; Green, R. G.

2017-09-01

Understanding magmatic plumbing within the Earth's crust is important for understanding volcanic systems and improving eruption forecasting. We discuss magma plumbing under Bárðarbunga volcano, Iceland, over a 4 year period encompassing the largest Icelandic eruption in 230 years. Microseismicity extends through the usually ductile region of the Earth's crust, from 7 to 22 km depth in a subvertical column. Moment tensor solutions for an example earthquake exhibits opening tensile crack behavior. This is consistent with the deep (>7 km) seismicity being caused by the movement of melt in the normally aseismic crust. The seismically inferred melt path from the mantle source is offset laterally from the center of the Bárðarbunga caldera by 12 km, rather than lying directly beneath it. It is likely that an aseismic melt feed also exists directly beneath the caldera and is aseismic due to elevated temperatures and pervasive partial melt under the caldera.

The nanotech R&D situation in Japan and ethics of nanotechnology.

Science.gov (United States)

Kato, Yutaka

2011-01-01

The aim of this paper is to introduce some characteristics of the historical as well as current situation of nanotech research and development in Japan in particular including regulations, and to discuss how ethical issues of nanotechnology should be addressed or how the ethics of nanotechnology should be constructed to fit the situation. The first part will center around the strength and weakness of Japan's nanotech R&D (research and development) and new circumstances which nanotechnology has prompted in Japan and alongside which nanotechnology has arrived (especially interdisciplinarity). The following prescriptive argument will, based on the descriptive account, question how to address ethical issues of nanotechnology, taking into consideration the nature of nanotech R&D, namely continuity, uniqueness, international dimension and political intervention, citing the example of the pharmaceutical industry. I will argue that international cooperation in the form of mutual reference to, replication of and the integration of guidelines and regulations, can enhance cost-effectiveness to ensure the comprehensiveness of regulatory measures.

Energy efficient data centers

Energy Technology Data Exchange (ETDEWEB)

Tschudi, William; Xu, Tengfang; Sartor, Dale; Koomey, Jon; Nordman, Bruce; Sezgen, Osman

2004-03-30

Data Center facilities, prevalent in many industries and institutions are essential to California's economy. Energy intensive data centers are crucial to California's industries, and many other institutions (such as universities) in the state, and they play an important role in the constantly evolving communications industry. To better understand the impact of the energy requirements and energy efficiency improvement potential in these facilities, the California Energy Commission's PIER Industrial Program initiated this project with two primary focus areas: First, to characterize current data center electricity use; and secondly, to develop a research ''roadmap'' defining and prioritizing possible future public interest research and deployment efforts that would improve energy efficiency. Although there are many opinions concerning the energy intensity of data centers and the aggregate effect on California's electrical power systems, there is very little publicly available information. Through this project, actual energy consumption at its end use was measured in a number of data centers. This benchmark data was documented in case study reports, along with site-specific energy efficiency recommendations. Additionally, other data center energy benchmarks were obtained through synergistic projects, prior PG&E studies, and industry contacts. In total, energy benchmarks for sixteen data centers were obtained. For this project, a broad definition of ''data center'' was adopted which included internet hosting, corporate, institutional, governmental, educational and other miscellaneous data centers. Typically these facilities require specialized infrastructure to provide high quality power and cooling for IT equipment. All of these data center types were considered in the development of an estimate of the total power consumption in California. Finally, a research ''roadmap'' was developed

Effect of thumus cell injections on germinal center formation in lymphoid tissues of nude (thymusless) mice

International Nuclear Information System (INIS)

Jacobson, E.B.; Caporale, L.H.; Thorbecke, G.J.

1974-01-01

Nude mice, partially backcrossed to Balb/c or DBA/2, were injected iv with 5 x 10 7 thymus cells from the respective inbred strain. The response of these mice to immunization with Brucella abortus antigen was studied, with respect to both antibody production and the formation of germinal centers in their lymphoid tissues. The results were compared to those obtained with nude mice to which no thymus cells were given, as well as to Balb/c, DBA/2, or +/question litter mate controls. Nude mice formed less 19S as well as 7S antibody than did litter mate controls and completely lacked germinal centers in lymph nodes and gut-associated lymphoid tissue. Those nude mice which had been injected with thymus cells made a much better secondary response, both for 19S and for 7S antibody, and had active germinal centers in their lymph nodes as early as 3 wk after thymus cell injection. Intestinal lymphoid tissue in nude mice showed only slight reconstitution of germinal center activity several months after thymus cell injection and none at earlier times. Irradiated (3000 R) thymus cells appeared as effective as normal cells in facilitating germinal center appearance and 7S antibody production in the nude mice

miR319, miR390, and miR393 Are Involved in Aluminum Response in Flax (Linum usitatissimum L.).

Science.gov (United States)

Dmitriev, Alexey A; Kudryavtseva, Anna V; Bolsheva, Nadezhda L; Zyablitsin, Alexander V; Rozhmina, Tatiana A; Kishlyan, Natalya V; Krasnov, George S; Speranskaya, Anna S; Krinitsina, Anastasia A; Sadritdinova, Asiya F; Snezhkina, Anastasiya V; Fedorova, Maria S; Yurkevich, Olga Yu; Muravenko, Olga V; Belenikin, Maxim S; Melnikova, Nataliya V

2017-01-01

Acid soils limit agricultural production worldwide. Major reason of crop losses in acid soils is the toxicity of aluminum (Al). In the present work, we investigated expression alterations of microRNAs in flax ( Linum usitatissimum L.) plants under Al stress. Flax seedlings of resistant (TMP1919 and G1071/4_k) and sensitive (Lira and G1071/4_o) to Al cultivars and lines were exposed to AlCl 3 solution for 4 and 24 hours. Twelve small RNA libraries were constructed and sequenced using Illumina platform. In total, 97 microRNAs from 18 conserved families were identified. miR319, miR390, and miR393 revealed expression alterations associated with Al treatment of flax plants. Moreover, for miR390 and miR393, the alterations were distinct in sensitive and resistant to Al genotypes. Expression level changes of miR319 and miR390 were confirmed using qPCR analysis. In flax, potential targets of miR319 are TCPs, miR390-TAS3 and GRF5, and miR393-AFB2-coding transcripts. TCPs, TAS3, GRF5, and AFB2 participate in regulation of plant growth and development. The involvement of miR319, miR390, and miR393 in response to Al stress in flax was shown here for the first time. We speculate that these microRNAs play an important role in Al response via regulation of growth processes in flax plants.

Handbook on data centers

CERN Document Server

Khan, Samee Ullah

2015-01-01

This handbook offers a comprehensive review of the state-of-the-art research achievements in the field of data centers. Contributions from international, leading researchers and scholars offer topics in cloud computing, virtualization in data centers, energy efficient data centers, and next generation data center architecture.  It also comprises current research trends in emerging areas, such as data security, data protection management, and network resource management in data centers. Specific attention is devoted to industry needs associated with the challenges faced by data centers, such as various power, cooling, floor space, and associated environmental health and safety issues, while still working to support growth without disrupting quality of service. The contributions cut across various IT data technology domains as a single source to discuss the interdependencies that need to be supported to enable a virtualized, next-generation, energy efficient, economical, and environmentally friendly data cente...

Integrated management system for radioactive waste repositories (SGI3R)

International Nuclear Information System (INIS)

Silva, Fabio; Tello, Cledola Cassia Oliveira de

2009-01-01

The implantation of a repository for radioactive wastes is a multidisciplinary project that needs specialists of different areas of knowledge, interaction with public and private institutions, data and information related to radioactive wastes, geology, technology etc. All the activities must be in accordance with norms, requirements and procedures, including national and international legislation. The maintenance of the waste inventory records is an important regulatory requirement and must be available even after the closure of the repository. CDTN - Center of Nuclear Technology Development - is coordinating the Project for the construction of the national repository to dispose the low -and intermediate-level wastes. In order to consolidate all information that will come from this Project, it is being developed and implanted in CDTN a manager system of database, called Integrated Management System for Radioactive Waste Repositories (SGI3R), which will also manage all data from previous work carried out in Brazil and around the world about this subject. The proposal is to build a structure of modules, having as base eight modules: inventory, site selection, types of repository, technology, partners, legislation, communication and documents. The SGI3R running comprises the data processing (inclusion, update and exclusion), integration, standardization, and consistency among the processes. The SGI3R will give support to the stages of this Project, which will allow the preservation of all the available information, preventing duplication of efforts and additional costs, improving, in this way, the Project planning and execution. Additionally the SGI3R will make possible the information access to all stakeholders. (author)

Actions Needed to Ensure Scientific and Technical Information is Adequately Reviewed at Goddard Space Flight Center, Johnson Space Center, Langley Research Center, and Marshall Space Flight Center

Science.gov (United States)

2008-01-01

This audit was initiated in response to a hotline complaint regarding the review, approval, and release of scientific and technical information (STI) at Johnson Space Center. The complainant alleged that Johnson personnel conducting export control reviews of STI were not fully qualified to conduct those reviews and that the reviews often did not occur until after the STI had been publicly released. NASA guidance requires that STI, defined as the results of basic and applied scientific, technical, and related engineering research and development, undergo certain reviews prior to being released outside of NASA or to audiences that include foreign nationals. The process includes technical, national security, export control, copyright, and trade secret (e.g., proprietary data) reviews. The review process was designed to preclude the inappropriate dissemination of sensitive information while ensuring that NASA complies with a requirement of the National Aeronautics and Space Act of 1958 (the Space Act)1 to provide for the widest practicable and appropriate dissemination of information resulting from NASA research activities. We focused our audit on evaluating the STI review process: specifically, determining whether the roles and responsibilities for the review, approval, and release of STI were adequately defined and documented in NASA and Center-level guidance and whether that guidance was effectively implemented at Goddard Space Flight Center, Johnson Space Center, Langley Research Center, and Marshall Space Flight Center. Johnson was included in the review because it was the source of the initial complaint, and Goddard, Langley, and Marshall were included because those Centers consistently produce significant amounts of STI.

75 FR 80372 - Proposed Amendment of Restricted Areas R-2907A and R-2907B, Lake George, FL; and R-2910...

Science.gov (United States)

2010-12-22

...-1146; Airspace Docket No. 10-ASO-25] Proposed Amendment of Restricted Areas R-2907A and R-2907B, Lake George, FL; and R-2910, Pinecastle, FL AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice... limits of restricted areas R-2907A and R-2907B, Lake George, FL; and restricted area R-2910, Pinecastle...

Search for gravitinos in R-parity violating supersymmetry at HERA

Energy Technology Data Exchange (ETDEWEB)

Horn, C.

2006-07-15

In this thesis a search for gravitinos in R{sub P}-violating supersymmetry is presented using data recorded with the ZEUS detector in the years 1996 to 2005, corresponding to an integrated luminosity of 300 pb{sup -1}. Collisions are recorded from e{sup -}p and e{sup +}p scattering at center-of-mass energies of 300 GeV and 318 GeV, using unpolarised as well as polarised lepton beams. Gravitinos are naturally expected in Gauge Mediated Supersymmetry Breaking (GMSB) models where the gravitino is the lightest supersymmetric particle. At HERA gravitinos may result from the GMSB decay of neutralinos ({chi}{sup 0}{yields}{gamma}G) produced in t-channel slepton exchange processes (eq{yields}q'{chi}) via an R{sub P}-violating (R{sub P}) Yukawa coupling {lambda}'{sub ijk}. It was assumed that only one of the R{sub P} couplings {lambda}'{sub 111}, {lambda}'{sub 121}, {lambda}'{sub 112} or {lambda}'{sub 113} is different from zero at a time. To extend the investigated GMSB parameter space, also the two dominant R{sub P}-violating decay channels ({chi}{yields}e{sup {+-}}qq and {chi}{yields}{nu}qq) were taken into account. For the signal-to-background optimisation a dynamic discriminant method was developed. The data was observed to be well described by the expected Standard Model processes and no evidence for the production of supersymmetric particles was found. Limits were calculated for the masses of the left-handed selectron and the lightest neutralino and the variation of these limits was investigated in the entire GMSB parameter space. For some parameter regions, selectron masses of up to 360 GeV and neutralino masses of up to 190 GeV can be excluded at 95% CL. Similar mass limits were found to hold for large regions of GMSB parameter space. (orig.)

Search for gravitinos in R-parity violating supersymmetry at HERA

International Nuclear Information System (INIS)

Horn, C.

2006-07-01

In this thesis a search for gravitinos in R P -violating supersymmetry is presented using data recorded with the ZEUS detector in the years 1996 to 2005, corresponding to an integrated luminosity of 300 pb -1 . Collisions are recorded from e - p and e + p scattering at center-of-mass energies of 300 GeV and 318 GeV, using unpolarised as well as polarised lepton beams. Gravitinos are naturally expected in Gauge Mediated Supersymmetry Breaking (GMSB) models where the gravitino is the lightest supersymmetric particle. At HERA gravitinos may result from the GMSB decay of neutralinos (χ 0 →γG) produced in t-channel slepton exchange processes (eq→q'χ) via an R P -violating (R P ) Yukawa coupling λ' ijk . It was assumed that only one of the R P couplings λ' 111 , λ' 121 , λ' 112 or λ' 113 is different from zero at a time. To extend the investigated GMSB parameter space, also the two dominant R P -violating decay channels (χ→e ± qq and χ→νqq) were taken into account. For the signal-to-background optimisation a dynamic discriminant method was developed. The data was observed to be well described by the expected Standard Model processes and no evidence for the production of supersymmetric particles was found. Limits were calculated for the masses of the left-handed selectron and the lightest neutralino and the variation of these limits was investigated in the entire GMSB parameter space. For some parameter regions, selectron masses of up to 360 GeV and neutralino masses of up to 190 GeV can be excluded at 95% CL. Similar mass limits were found to hold for large regions of GMSB parameter space. (orig.)

miR-371, miR-138, miR-544, miR-145, and miR-214 could modulate Th1/Th2 balance in asthma through the combinatorial regulation of Runx3.

Science.gov (United States)

Qiu, Yu-Ying; Zhang, Ying-Wei; Qian, Xiu-Fen; Bian, Tao

2017-01-01

Asthma is tightly related to the imbalance of Th1/Th2 cells, and Runx3 plays a pivotal role in the differentiation of T helper cells. The present study aimed to investigate dysregulated microRNAs that may target Runx3 in CD4 + T cells from asthmatic patients and reveal Runx3 function in Th1/Th2 balance regulation. We detected the levels of Th1- and Th2-related cytokines by ELISA and analyzed the differentiation marker gene of T helper cells by qRT-PCR. Results indicated that an imbalance of Th1/Th2 cells was present in our asthmatic subject. Runx3 expression was reduced in the CD4 + T cells from asthmatic patients. Overexpression of Runx3 could restore the Th1/Th2 balance. After performing microRNA microarray assay, we found a series of microRNAs that were considerably altered in the CD4 + T cells from asthmatic patients. Among these upregulated microRNAs, eight microRNAs that may target Runx3 were selected by bioinformatics prediction. Five microRNAs, namely miR-371, miR-138, miR-544, miR-145, and miR-214, were confirmed by qRT-PCR and selected as candidate microRNAs. Luciferase reporter assay showed that these five microRNAs could directly target the 3'-UTR of Runx3. However, only simultaneous inhibition of these five microRNAs could alter the expression of Runx3. Most importantly, only simultaneous inhibition could improve the Th1/Th2 balance. Thus, we suggest that miR-371, miR-138, miR-544, miR-145, and miR-214 can modulate the Th1/Th2 balance in asthma by regulating Runx3 in a combinatorial manner.

Nucleolar TRF2 attenuated nucleolus stress-induced HCC cell-cycle arrest by altering rRNA synthesis.

Science.gov (United States)

Yuan, Fuwen; Xu, Chenzhong; Li, Guodong; Tong, Tanjun

2018-05-03

The nucleolus is an important organelle that is responsible for the biogenesis of ribosome RNA (rRNA) and ribosomal subunits assembly. It is also deemed to be the center of metabolic control, considering the critical role of ribosomes in protein translation. Perturbations of rRNA synthesis are closely related to cell proliferation and tumor progression. Telomeric repeat-binding factor 2 (TRF2) is a member of shelterin complex that is responsible for telomere DNA protection. Interestingly, it was recently reported to localize in the nucleolus of human cells in a cell-cycle-dependent manner, while the underlying mechanism and its role on the nucleolus remained unclear. In this study, we found that nucleolar and coiled-body phosphoprotein 1 (NOLC1), a nucleolar protein that is responsible for the nucleolus construction and rRNA synthesis, interacted with TRF2 and mediated the shuttle of TRF2 between the nucleolus and nucleus. Abating the expression of NOLC1 decreased the nucleolar-resident TRF2. Besides, the nucleolar TRF2 could bind rDNA and promoted rRNA transcription. Furthermore, in hepatocellular carcinoma (HCC) cell lines HepG2 and SMMC7721, TRF2 overexpression participated in the nucleolus stress-induced rRNA inhibition and cell-cycle arrest.

Squalene and cholesterol in dust from Danish homes and daycare centers

DEFF Research Database (Denmark)

Weschler, Charles J.; Langer, Sarka; Fischer, Andreas

2011-01-01

.4; daycare centers: GM = 220 μg/g, GSD = 4.0). Correlations between squalene and cholesterol were weak (r = 0.22). Furthermore, the median squalene-to-cholesterol ratio in dust (0.05) was more than an order of magnitude smaller than that in skin oil. This implies sources in addition to desquamation (e.......g., cholesterol from cooking) coupled, perhaps, with a shorter indoor lifetime for squalene. Estimated values of squalene’s vapor pressure, while uncertain, suggest meaningful redistribution from dust to other indoor compartments. We estimate that dust containing squalene at 60 μg/g would contribute about 4...

Crustal accretion at a sedimented spreading center in the Andaman Sea

Digital Repository Service at National Institute of Oceanography (India)

Jourdain, A.; Singh, S.C.; Escartin, J.; Klinger, Y.; KameshRaju, K.A.; Mc

sedimented spreading center in the 1 Andaman Sea2 Aurélie Jourdain1, Satish C. Singh1, Javier Escartin1, Yann Klinger1, K. A. Kamesh Raju2,3 J. McArdle3 4 1Institut de Physique du Globe de Paris, Sorbonne Paris Cité, UMR7154-CNRS, 1 rue Jussieu, 5 78238... Singh, S. C., Moeremans, R., McArdle, J., and Johansen, K., 2013, Seismic images of the sliver 327 strike-slip fault and back thrust in the Andaman-Nicobar region: Journal of Geophysical 328 Research: Solid Earth, v. 118, p. 5208-5224. 329 Sleep, N. H...

Poison Control Centers

Science.gov (United States)

... 1222 immediately. Name State American Association of Poison Control Centers Address AAPCC Central Office NOT A POISON ... not for emergency use. Arkansas ASPCA Animal Poison Control Center Address 1717 S. Philo Road, Suite 36 Urbana, ...

Interaction of Pleuromutilin Derivatives with the Ribosomal Peptidyl Transferase Center

Science.gov (United States)

Long, Katherine S.; Hansen, Lykke H.; Jakobsen, Lene; Vester, Birte

2006-01-01

Tiamulin is a pleuromutilin antibiotic that is used in veterinary medicine. The recently published crystal structure of a tiamulin-50S ribosomal subunit complex provides detailed information about how this drug targets the peptidyl transferase center of the ribosome. To promote rational design of pleuromutilin-based drugs, the binding of the antibiotic pleuromutilin and three semisynthetic derivatives with different side chain extensions has been investigated using chemical footprinting. The nucleotides A2058, A2059, G2505, and U2506 are affected in all of the footprints, suggesting that the drugs are similarly anchored in the binding pocket by the common tricyclic mutilin core. However, varying effects are observed at U2584 and U2585, indicating that the side chain extensions adopt distinct conformations within the cavity and thereby affect the rRNA conformation differently. An Escherichia coli L3 mutant strain is resistant to tiamulin and pleuromutilin, but not valnemulin, implying that valnemulin is better able to withstand an altered rRNA binding surface around the mutilin core. This is likely due to additional interactions made between the valnemulin side chain extension and the rRNA binding site. The data suggest that pleuromutilin drugs with enhanced antimicrobial activity may be obtained by maximizing the number of interactions between the side chain moiety and the peptidyl transferase cavity. PMID:16569865

C.r.e.x. and Orion analysis in radiation oncology: Towards a mutualization of corrective actions

International Nuclear Information System (INIS)

Lartigau, E.; Vitoux, A.; Debouck, F.

2009-01-01

After working on treatment organization in radiotherapy (bonnes pratiques organisationnelles en radiotherapie - action pilote M.e.a.H. 2003), the development of a security policy has become crucial. With the help of Air France consulting and the M.e.a.H., three cancer centers in Angers, Lille et Villejuif worked together on the implantation of experience feed back committees (C.r.e.x.) dedicated to the registration, analysis and correction of precursor events. This action has now been implemented in all the F.N.C.L.C.C. centers. It seems now important to have a program of mutualization of corrective actions for all participants. This will allow to review the Orion method of events analysis. (authors)

LINE DERIVED INFRARED EXTINCTION TOWARD THE GALACTIC CENTER

International Nuclear Information System (INIS)

Fritz, T. K.; Gillessen, S.; Dodds-Eden, K.; Lutz, D.; Genzel, R.; Raab, W.; Ott, T.; Pfuhl, O.; Eisenhauer, F.; Yusef-Zadeh, F.

2011-01-01

We derive the extinction curve toward the Galactic center (GC) from 1 to 19 μm. We use hydrogen emission lines of the minispiral observed by ISO-SWS and SINFONI. The extinction-free flux reference is the 2 cm continuum emission observed by the Very Large Array. Toward the inner 14'' x 20'', we find an extinction of A 2.166μm = 2.62 ± 0.11, with a power-law slope of α = -2.11 ± 0.06 shortward of 2.8 μm, consistent with the average near-infrared slope from the recent literature. At longer wavelengths, however, we find that the extinction is grayer than shortward of 2.8 μm. We find that it is not possible to fit the observed extinction curve with a dust model consisting of pure carbonaceous and silicate grains only, and the addition of composite particles, including ices, is needed to explain the observations. Combining a distance-dependent extinction with our distance-independent extinction, we derive the distance to the GC to be R 0 = 7.94 ± 0.65 kpc. Toward Sgr A* (r H = 4.21 ± 0.10, A Ks = 2.42 ± 0.10, and A L' = 1.09 ± 0.13.

At R207

CERN Multimedia

1975-01-01

At the centre, a barrel shaped hodoscope surrounds the beams' crossing point. It was previously used for experiments R205 and R206 which did run in 1974. After their completion in mid 1975 the equipment of R205 was removed, and that of R206 was modified and rearranged to create two small angle spectrometers, one on each side of the intersection, for experiment R207 (diffraction dissociation and formation at small momentum transfer), by the CERN-Holland-Manchester Collaboration. (see also photos 7508109X and 7508113X) Here on the right, Lars Leistam.

Upregulation of miR-150* and miR-630 induces apoptosis in pancreatic cancer cells by targeting IGF-1R.

Directory of Open Access Journals (Sweden)

Lulu Farhana

Full Text Available MicroRNAs have been implicated in many critical cellular processes including apoptosis. We have previously found that apoptosis in pancreatic cancer cells was induced by adamantyl retinoid-related (ARR molecule 3-Cl-AHPC. Here we report that 3-Cl-AHPC-dependent apoptosis involves regulating a number of microRNAs including miR-150* and miR-630. 3-Cl-AHPC stimulated miR-150* expression and caused decreased expression of c-Myb and IGF-1R in the pancreatic cancer cells. 3-Cl-AHPC-mediated reduction of c-Myb resulted in diminished binding of c-Myb with IGF-1R and Bcl-2 promoters, thereby causing repression of their transcription and protein expression. Over-expression of miR-150* also resulted in diminished levels of c-Myb and Bcl-2 proteins. Furthermore, the addition of the miRNA inhibitor 2'-O-methylated miR-150 blocked 3-Cl-AHPC-mediated increase in miR-150* levels and abrogated loss of c-Myb protein. Knockdown of c-Myb in PANC-1 cells resulted in enhanced apoptosis both in the presence or absence of 3-Cl-AHPC confirming the anti-apoptotic property of c-Myb. Overexpression of miR-630 also induced apoptosis in the pancreatic cancer cells and inhibited target protein IGF-1R mRNA and protein expression. Together these results implicate key roles for miR-150* and miR-630 and their targeting of IGF-1R to promote apoptosis in pancreatic cancer cells.

Similarity of WISC-R and WAIS-R Scores at Age 16.

Science.gov (United States)

Sandoval, Jonathan; And Others

1988-01-01

Examined similarity of scores of 30 learning disabled students (aged 16 and 17) on the Wechsler Intelligence Scale for Children-Revised (WISC-R) and the Wechsler Adult Intelligence Scale-Revised (WAIS-R). Results documented similarity between WISC-R and WAIS-R for 16 year-olds who were learning disabled and had average intellectual ability.…

Present status of two R.F. heating schemes: I.C.R.H. and L.H.R.H

International Nuclear Information System (INIS)

Consoli, T.

1977-01-01

Among the large number of wave-plasma interaction, Ion-Cyclotron Resonant Heating (I.C.R.H.) and Lower Hybrid Resonant Heating (L.H.R.H.), are two promising additional R.F. heating schemes for toroidal hot plasma. They both offer the advantage of using power generators which requires a moderate development for next generation machines. It seems important to try to state in the limits of this paper the present experimental situation of these two R.F. heating methods as it results from the vast literature published from the last European Conference

Systembolagets monopol kontra EU:s fria rörlighet för varor

OpenAIRE

Edqvist, Daniel; Gisslén, Kristofer

2006-01-01

Denna uppsats strävar efter att besvara frågorna: Har systembolaget rätt att som ensam aktör bedriva detaljhandel av alkohol i Sverige? Strider nuvarande reglering av svensk import och export av vin och sprit mot EG-rätten? EG-domstolen har i flera fall rörande offentliga monopol fastslagit att dessa i sig inte utgör något brott mot EG-rätten, under förutsättning att de anpassas till övrig EG-rätt på konkurrensrättens område. Det är därför med anledning av detta fullt möjligt för Systembolage...

Los Angeles International Airport Runway Incursion Studies: Phase III--Center-Taxiway Simulation

Science.gov (United States)

Madson, Michael D.

2004-01-01

Phase III of the Los Angeles International Airport Runway Incursion Studies was conducted, under an agreement with HNTB Corporation, at the NASA Ames FutureFlight Central (FFC) facility in June 2003. The objective of the study was the evaluation of a new center-taxiway concept at LAX. This study is an extension of the Phase I and Phase II studies previously conducted at FFC. This report presents results from Phase III of the study, in which a center-taxiway concept between runways 25L and 25R was simulated and evaluated. Phase III data were compared objectively against the Baseline data. Subjective evaluations by participating LAX controllers were obtained with regard to workload, efficiency, and safety criteria. To facilitate a valid comparison between Baseline and Phase III data, the same scenarios were used for Phase III that were tested during Phases I and II. This required briefing participating controllers on differences in airport and airline operations between 2001 and today.

The R Commander: A Basic-Statistics Graphical User Interface to R

Directory of Open Access Journals (Sweden)

John Fox

2005-08-01

Full Text Available Unlike S-PLUS, R does not incorporate a statistical graphical user interface (GUI, but it does include tools for building GUIs. Based on the tcltk package (which furnishes an interface to the Tcl/Tk GUI toolkit, the Rcmdr package provides a basic-statistics graphical user interface to R called the "R Commander." The design objectives of the R Commander were as follows: to support, through an easy-to-use, extensible, cross-platform GUI, the statistical functionality required for a basic-statistics course (though its current functionality has grown to include support for linear and generalized-linear models, and other more advanced features; to make it relatively difficult to do unreasonable things; and to render visible the relationship between choices made in the GUI and the R commands that they generate. The R Commander uses a simple and familiar menu/dialog-box interface. Top-level menus include File, Edit, Data, Statistics, Graphs, Models, Distributions, Tools, and Help, with the complete menu tree given in the paper. Each dialog box includes a Help button, which leads to a relevant help page. Menu and dialog-box selections generate R commands, which are recorded in a script window and are echoed, along with output, to an output window. The script window also provides the ability to edit, enter, and re-execute commands. Error messages, warnings, and some other information appear in a separate messages window. Data sets in the R Commander are simply R data frames, and can be read from attached packages or imported from files. Although several data frames may reside in memory, only one is "active" at any given time. There may also be an active statistical model (e.g., an R lm or glm ob ject. The purpose of this paper is to introduce and describe the use of the R Commander GUI; to describe the design and development of the R Commander; and to explain how the R Commander GUI can be extended. The second part of the paper (following a brief

Relative Lyapunov Center Bifurcations

DEFF Research Database (Denmark)

Wulff, Claudia; Schilder, Frank

2014-01-01

Relative equilibria (REs) and relative periodic orbits (RPOs) are ubiquitous in symmetric Hamiltonian systems and occur, for example, in celestial mechanics, molecular dynamics, and rigid body motion. REs are equilibria, and RPOs are periodic orbits of the symmetry reduced system. Relative Lyapunov...... center bifurcations are bifurcations of RPOs from REs corresponding to Lyapunov center bifurcations of the symmetry reduced dynamics. In this paper we first prove a relative Lyapunov center theorem by combining recent results on the persistence of RPOs in Hamiltonian systems with a symmetric Lyapunov...... center theorem of Montaldi, Roberts, and Stewart. We then develop numerical methods for the detection of relative Lyapunov center bifurcations along branches of RPOs and for their computation. We apply our methods to Lagrangian REs of the N-body problem....

Temperature characterization of deep and shallow defect centers of low noise silicon JFETs

International Nuclear Information System (INIS)

Arnaboldi, Claudio; Fascilla, Andrea; Lund, M.W.; Pessina, Gianluigi

2004-01-01

We have selected different low noise JFET processes that have shown outstanding dynamic and noise performance at both room temperature and low temperatures. We have studied JFETs made with a process optimized for cryogenic operation, testing several devices of varying capacitance. For most of them, we have been able to detect the presence of shallow individual traps at low temperature which create low frequency (LF) Generation-Recombination (G-R) noise. For one device type no evidence of traps has been observed at the optimum temperature of operation (around 100 K). It had a very small residual LF noise. This device has been cooled down to 14 K. From below 100 K down to 14 K the noise was observed to increase due to G-R noise originating from donor atoms (dopants) inside the channel. A very simple theoretical interpretation confirms the nature of G-R noise from these very shallow trapping centers. We also studied devices from a process optimized for room temperature operation and found noise corresponding to the presence of a single deep level trap. Even for this circumstance the theory was experimentally confirmed. The measurement approach we used allowed us to achieve a very high accuracy in the modeling of the measured G-R noise. The ratio of the density of the atoms responsible for G-R noise above the doping concentration, N T /N d , has been verified with a sensitivity around 10 -7

Test Report #33: Compressor Calorimeter Test of R-410A Alternative: R-32/R-134a Mixture Using a Scroll Compressor

Energy Technology Data Exchange (ETDEWEB)

Shrestha, Som [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sharma, Vishaldeep [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Abdelaziz, Omar [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

2014-02-18

This report investigates the tested performance of lower - GWP candidate refrigerant, 94.07 wt% R - 32 + 5.93 wt % R - 134 a mixture (hereafter referred to as R - 32/134a), as an alternative to baseline refrigerant R - 410 A using a 36,000 Btu/hr compressor calorimeter located at the Heat Exchanger Advanced Testing Facility at Oak Ridge National Laboratory . These tests were conducted during May and August 2013. R - 410A is a near - azeotropic blend of R - 32 and R - 125 with 0.5/0.5 mass fraction and has a GWP 100 of 2100. R - 32 and R - 134a are pure refrigerants and have GWP 100 of 716 and 1370 1, respectively. Based on the GWP 100 values of pure refrigerants and their mass fraction in the blend, GWP 100 of R - 32/134a, which is under development by National Refrigerant, is 755. This report compares various performance parameters, such as cooling capacity, compressor power, refrigerant mass flow rate, EER, isentropic efficiency and discharge temperature of the alternative refrigerant to that of R - 410 A.

Çâr-Ender-Çâr Poems in Classical Turkish Literature

OpenAIRE

TOPAL, Ahmet

2017-01-01

Çâr-ender-çâr is a Persian term, which means quartet and four in four. This term is used in classical Turkish poetry for different poems, which have a common form as a quartet structure and style. Çâr-ender-çâr is used generally with the literary arts like leff ü neşr, taksîm, tensîkü’s-sıfat and known as the poems, which are constructed in a quartet parallelism. Other poems, which are qualified as çâr-ender-çâr are the verses, called in murabba style. These poems are accepted generally as th...

R-values

International Nuclear Information System (INIS)

Roberts, K.

2009-01-01

I'll try to keep this short and simple. R LANL = (beta cpm of X exp on system 'A')/ (beta cpm of 99 Mo exp on system 'A')/ (beta cpm of X on system 'A', from thermal on 235 U)/ (beta cpm of 99 Mo on system 'A', from thermal on 235 U). As I understand it, the above equation is the historical (as well as current) way of determining R-values using data from beta counting at LANL. The ratio in the denominator, a little 'r', is the 'baseline' or 'calibration' value for a specific beta detector. Over time, if the detector 'drifts' one would see a variation in this 'r' during a thermal calibration measurement. This baseline is what LANL likes to track to monitor specific detector performance - this is not relevant to LLNL where gamma detection is used for determining R-values. LANL states that uncertainty is only dependent upon the count statistics for the isotopes measured. If one tries to convert this to an atom basis, the uncertainties will increase due to the incorporation of the uncertainties in the nuclear data used to convert the cpm to atoms. LLNL switched to gamma detection methods in the 1970s thus replacing our beta counting effort. The equation below is how we have since determined R-values. The numerator ratios atom values of isotopes that are determined by measuring gamma cpm (usually? using several peaks per isotope) and then converting to particle decay in dpm using detector efficiency for each peak and the appropriate branch ratio for each gamma emission. Isotope decay is then converted to atoms using specific activity, mass or volume?, and Avogadro's number. The denominator is simply the ratio of published, cumulative fission product chain yields for isotopes produced in a thermal irradiation on 235U - values of England and Ryder are used by LLNL for the NTNF program. Uncertainties in LLNL R-values are dependent upon gamma counting statistics as well as the nuclear data for each isotope. R LLNL = (Atoms of X exp )/(Atoms of 99 Mo exp )/(Cumulative

R and Matlab

CERN Document Server

Hiebeler, David E

2015-01-01

The First Book to Explain How a User of R or MATLAB Can Benefit from the OtherIn today's increasingly interdisciplinary world, R and MATLAB® users from different backgrounds must often work together and share code. R and MATLAB® is designed for users who already know R or MATLAB and now need to learn the other platform. The book makes the transition from one platform to the other as quick and painless as possible.Enables R and MATLAB Users to Easily Collaborate and Share CodeThe author covers essential tasks, such as working with matrices and vectors, writing functions and other programming co

Center of buoyancy definition

International Nuclear Information System (INIS)

Sandberg, V.

1988-12-01

The center of buoyancy of an arbitrary shaped body is defined in analogy to the center of gravity. The definitions of the buoyant force and center of buoyancy in terms of integrals over the area of the body are converted to volume integrals and shown to have simple intuitive interpretations

Person-centered psychotherapy and the impact of the experiencing concept / Psicoterapia centrada na pessoa e o impacto do conceito de experienciação

OpenAIRE

João Carlos Caselli Messias; Vera Engler Cury

2006-01-01

The article discusses the conceptual contributions of Eugene T. Gendlin to the development of the Person-Centered Approach theory, from Carl R. Rogers, with a special distinction to Experiencing. A brief biography of the first author is presented to the Portuguese reader as well as the developments of his Philosophy of the Implicit, a specific approach nowadays. The benefits that an experiential comprehension is able to offer to the Person-Centered Professionals are also analyzed.

NREL's Education Center Programs | NREL

Science.gov (United States)

NREL's Education Center Programs NREL's Education Center Programs There are a variety of educational programs offered through NREL's education center to inspire our community to explore the science neighbors, campus and trail maps, and more. A photo of the NREL Education Center exterior. Programs for

Alternative Fuels Data Center: Biodiesel

Science.gov (United States)

Biodiesel Printable Version Share this resource Send a link to Alternative Fuels Data Center : Biodiesel to someone by E-mail Share Alternative Fuels Data Center: Biodiesel on Facebook Tweet about Alternative Fuels Data Center: Biodiesel on Twitter Bookmark Alternative Fuels Data Center: Biodiesel on

Annual energy performance of R744 and R410A heat pumping systems

International Nuclear Information System (INIS)

Jin, Zhequan; Eikevik, Trygve M.; Nekså, Petter; Hafner, Armin; Wang, Ruzhu

2017-01-01

Highlights: • Annual energy performance of R744 and R410A heat pumping systems is compared. • Several dynamic models of heat pumping systems are developed. • Annual energy efficiency of R744 hybrid ground-coupled heat pumping system. • The seasonal COPc and COPh of R744 hybrid system are 3.55 and 3.32. • The superiority of R744 system on the integration of two heat sinks is discussed. - Abstract: This work compares the annual energy performance of heat pumping systems using R744 and R410A as refrigerant. Focus is the annual energy efficiency of R744 hybrid ground-coupled heat pumping system. The hybrid system uses both ambient air and ground as heat sinks in the cooling mode. This is important to eliminate the underground heat accumulation phenomenon in warm climates. Several quasi-steady state models of heat pumping systems, using R744 and R410A, have been developed. Simulation results show that the annual COP_c and COP_h of an R744 hybrid system reaches 3.55 and 3.32, and its cooling performance is 42% better than for a R744 ASHP and 23% better than for a R744 GCHP system. The annual energy performance factor of a R410A ASHP system is better than for a R744 hybrid system, but the COP_c for the R410A system will be lower when the ambient temperature is higher than 30 °C.

AND/R: Advanced neutron diffractometer/reflectometer for investigation of thin films and multilayers for the life sciences

International Nuclear Information System (INIS)

Dura, Joseph A.; Pierce, Donald J.; Majkrzak, Charles F.; Maliszewskyj, Nicholas C.; McGillivray, Duncan J.; Loesche, Mathias; O'Donovan, Kevin V.; Mihailescu, Mihaela; Perez-Salas, Ursula; Worcester, David L.; White, Stephen H.

2006-01-01

An elastic neutron scattering instrument, the advanced neutron diffractometer/reflectometer (AND/R), has recently been commissioned at the National Institute of Standards and Technology Center for Neutron Research. The AND/R is the centerpiece of the Cold Neutrons for Biology and Technology partnership, which is dedicated to the structural characterization of thin films and multilayers of biological interest. The instrument is capable of measuring both specular and nonspecular reflectivity, as well as crystalline or semicrystalline diffraction at wave-vector transfers up to approximately 2.20 A -1 . A detailed description of this flexible instrument and its performance characteristics in various operating modes are given

Monte Carlo determinations of the functions Λ(r, Z), G(r, θ), g(R) and F(r, θ) for Amersham CDCS-M-type 137Cs source

International Nuclear Information System (INIS)

Valdez, F. Roberto Fragoso; Alvarez Romero, J. Trinidad

2001-01-01

The functions Λ(r, z), G(r, θ), g(r) and F(r, θ) were calculated for Amersham model CDCS-M-type 137 Cs source by means of Monte Carlo simulation using the algorithm PENELOPE. These functions are required to verify and/or to feed planning systems or directly as entrance data for the manual planning of the distribution of absorbed dose according with the recommendations of the TG 43, [1]. The values of the constant Λ (r, Z) were determined as the quotient of absorbed dose rate distribution in water and air kerma strength in 'free air' S k . The values obtained for Λ (r, Z) differ up to 3% of those reported in the literature, being very sensitive to the cutoff energy for the electrons in the interface of the source's encapsulated and water

Praksisnær skoleudvikling og PLC som strategisk udviklingsaktør

DEFF Research Database (Denmark)

Christensen, Ole; Bach, Anna

2017-01-01

I det følgende belyses, hvorledes PLC kan udvikles som strategisk udviklingsaktør og understøtte praksisnær skoleudvikling. Vi ønsker at belyse hvorledes Bekendtgørelsens overordnede intentioner kan få retning og rammer og dermed medvirke til, at hele det pædagogiske personale indgår i skoleudvik......I det følgende belyses, hvorledes PLC kan udvikles som strategisk udviklingsaktør og understøtte praksisnær skoleudvikling. Vi ønsker at belyse hvorledes Bekendtgørelsens overordnede intentioner kan få retning og rammer og dermed medvirke til, at hele det pædagogiske personale indgår i...... skoleudviklingen. I den forbindelse er det vores erfaring, at PLC kan spille en central rolle i forbindelse med den praksisnære og lokale skoleudvikling. Erfaringerne bygger især på udviklings- og forskningsprojekter fra kommunerne Kolding, København, Roskilde og Tårnby. Der har været tale om praksisnære...

Knock-in human GDF5 proregion L373R mutation as a mouse model for proximal symphalangism.

Science.gov (United States)

Zhang, Xinxin; Xing, Xuesha; Liu, Xing; Hu, Yu; Qu, Shengqiang; Wang, Heyi; Luo, Yang

2017-12-26

Proximal symphalangism (SYM1) is an autosomal dominant disorder, mainly characterized by bony fusions of the proximal phalanges of the hands and feet. GDF5 and NOG were identified to be responsible for SYM1. We have previously reported on a p.Leu373Arg mutation in the GDF5 proregion present in a Chinese family with SYM1. Here, we investigated the effects of the GDF-L373R mutation. The variant caused proteolysis efficiency of GDF5 increased in ATDC5 cells. The variant also caused upregulation of SMAD1/5/8 phosphorylation and increased expression of target genes SMURF1 , along with COL2A1 and SOX9 which are factors associated with chondrosis. Furthermore, we developed a human-relevant SYM1 mouse model by making a Gdf5 L367R (the orthologous position for L373R in humans) knock-in mouse. Gdf5 L367R/+ and Gdf5 L367R/L367R mice displayed stiffness and adhesions across the proximal phalanx joint which were in complete accord with SYM1. It was also confirmed the joint formation and development was abnormal in Gdf5 L367R/+ and Gdf5 L367R/L367R mice, including the failure to develop the primary ossification center and be hypertrophic chondrocytes during embryonic development. This knock-in mouse model offers a tool for assessing the pathogenesis of SYM1 and the function of the GDF5 proregion.

Correspondence of f(R,∇R) Modified Gravity with Scalar Field Models

International Nuclear Information System (INIS)

Jawad, Abdul; Debnath, Ujjal

2014-01-01

This paper is devoted to study the scalar field dark energy models by taking its different aspects in the framework of f(R,∇R) gravity. We consider flat FRW universe to construct the equation of state parameter governed by f(R,∇R) gravity. The stability of the model is discussed with the help of squared speed of sound parameter. It is found that models show quintessence behavior of the universe in stable as well as unstable modes. We also develop the correspondence of f(R,∇R) model with some scalar field dark energy models like quintessence, tachyonic field, k-essence, dilaton, hessence, and DBI-essence. The nature of scalar fields and corresponding scalar potentials is being analyzed in f(R,∇R) gravity graphically which show consistency with the present day observations about accelerated phenomenon

Arbetstidsförkortning : för ökad arbetstillfredsställelse och bättre relationer.

OpenAIRE

Hultberg, Jenny; Klarenius, Karna; Liljekvist, Per

2004-01-01

Bakgrund: Redan på 1700-talet diskuterade Owen att det inte var bra att ha barn som arbetade långa arbetspass i treskift. Detta synsätt införde han på sin fabrik, vilket han fick mycket kritik för. Först 1962 väcktes tanken på 6-timmars arbetsdag i Sverige. Sedan dess har flera försök genomförts bl.a. hos Helsingborgs stads äldreomsorg, äldreomsorgen i Höganäs kommun samt Toyota Center i Mölndal. Problem: Dagens företag är relativt fokuserade på traditionella mått som t.ex. lönsamhet och prod...

Systems of transversal sections near critical energy levels of hamiltonian systems in $Mathbb{R}^{4}$

CERN Document Server

de, Naiara V

2018-01-01

In this article the authors study Hamiltonian flows associated to smooth functions H:\\mathbb R^4 \\to \\mathbb R restricted to energy levels close to critical levels. They assume the existence of a saddle-center equilibrium point p_c in the zero energy level H^{-1}(0). The Hamiltonian function near p_c is assumed to satisfy Moser's normal form and p_c is assumed to lie in a strictly convex singular subset S_0 of H^{-1}(0). Then for all E \\gt 0 small, the energy level H^{-1}(E) contains a subset S_E near S_0, diffeomorphic to the closed 3-ball, which admits a system of transversal sections \\mathcal F_E, called a 2-3 foliation. \\mathcal F_E is a singular foliation of S_E and contains two periodic orbits P_2,E\\subset \\partial S_E and P_3,E\\subset S_E\\setminus \\partial S_E as binding orbits. P_2,E is the Lyapunoff orbit lying in the center manifold of p_c, has Conley-Zehnder index 2 and spans two rigid planes in \\partial S_E. P_3,E has Conley-Zehnder index 3 and spans a one parameter family of planes in S_E \\setmin...

Accredited Birth Centers

Science.gov (United States)

... Danbury, CT 06810 203-748-6000 Accredited Since March 1998 Corvallis Birth & Women's Health Center Accredited 2314 NW Kings Blvd, Suite ... Washington, DC 20002 202-398-5520 Accredited Since March 2001 Flagstaff Birth and Women's Center Accredited 401 West Aspen Avenue Flagstaff, AZ ...

76 FR 40403 - R.E. Ginna Nuclear Power Plant, LLC, R.E. Ginna Nuclear Power Plant, R.E. Ginna Independent Spent...