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Sample records for quiste paratiroideo gigante

  1. Quiste gigante de ovario

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    Dagoberto Calderón Rodríguez

    2014-08-01

    Full Text Available Un crecimiento quístico del ovario debe medir por lo menos 2,5 cm de diámetro para denominarse quiste. Se presenta el caso de una paciente de 36 años, femenina, perteneciente a la etnia Wayú, con un quiste gigante en ovario derecho, de aproximadamente 10 cm de diámetro, un peso de 3,6 Kg y torcido sobre su pedículo, que le provoca dolor intenso de más de un mes de evolución. Se practicó intervención quirúrgica y se comprobaron signos macroscópicos de necrobiosis de ovario, siendo el resultado de la biopsia un teratoma maduro. Su resultado final fue satisfactorio

  2. Cirugía radioguiada para la extirpación de un quiste paratiroideo gigante con hiperparatiroidismo Radio-guided surgery for removal of a giant parathyroid cyst related to hyperthyroidism

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    Edelberto Fuentes Valdés

    2009-04-01

    Full Text Available Entre los avances actuales del tratamiento quirúrgico del hiperparatiroidismo se encuentra la localización preoperatoria de la(s glándula(s hiperfuncionante(s mediante gammagrafía preoperatoria e intraoperatoria, esta última a través de una sonda gamma especial. Por otro lado, los quistes paratiroideos son raros; pueden ser funcionantes o no. Se describe un nuevo caso de quiste paratiroideo hiperfuncionante, así como los hallazgos de la gammagrafía con 99mTc-MIBI y el uso intraoperatorio de la sonda gamma para evaluar todos los sitios probables donde pudieran existir glándulas hiperproductoras de hormona paratiroidea. Se describen aspectos de la manipulación, seguridad y administración del radiofármaco en el período preoperatorio inmediato, así como la utilización de la sonda gamma durante la intervención. Se informa la evolución durante el seguimiento. Este caso representa el tercer paciente intervenido por hiperparatiroidismo mediante cirugía radioguiada en nuestro centro, institución en la que se introdujo esta técnica en el paísAmong present advances of surgical treatment of hyperthyroidism is the preoperative localization of hyper-functioning glands by preoperative and intraoperative scan, this later one by a special gamma probe. By the other hand, parathyroid cysts are rare; may be of functioning type or not, as well as the findings of 99mTc-MIBI, and the intraoperative use of gamma probe to assess all the possible sites where could be hyperproductive glands of parathyroid hormone. We describe features of management, safety, and administration of radiological agent during the immediate preoperative period, as well as use of gamma probe during intervention. Evolution over follow-up is reported. This case represents the third patient operated on from hyperthyroidism by radio-guided surgery in our center, which introduced this technique in our country.

  3. Quistes gigantes infectados en el hígado

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    Dagoberto Calderón Rodríguez

    2015-06-01

    Full Text Available Los quistes hepáticos, tanto en cirugía de adulto como en pediatría, son entidades infrecuentes. Se presenta el caso de una paciente femenina, de 51 años de edad con múltiples quistes gigantes infectados en el hígado, el mayor de ellos de aproximadamente unos 15 - 20 cm. Se le practicó laparotomía de urgencia con exéresis casi total del lóbulo izquierdo del hígado y destechamiento del gran quiste del lóbulo derecho. La paciente ha sido reingresada en dos ocasiones por infección de los quistes hepáticos teniendo resolutividad con tratamiento farmacológico.

  4. Quiste pericárdico gigante en el adulto. Reporte de 1 caso

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    Orestes Noel Mederos Curbelo

    2001-12-01

    Full Text Available Se presenta una paciente de 62 años de edad con un quiste pericárdico celómico gigante sintomático. A pesar de tener 2 400 mL de líquido en su interior fue un diagnóstico fortuito en la radiografía de tórax. Se trató quirúrgicamente y tuvo una evolución satisfactoria.A 62 year-old-patient with a giant symptomatic pericardial coelomic cyst is presented. Despite having 2 400 mL of fluid in its interior, he had a fortuitous diagnosis in the chest X-rays. He was surgically treated and had a satisfactory evolution.

  5. Quiste de ovario gigante. Presentación de un caso

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    Yarisdey Corrales Hernández

    2012-09-01

    Full Text Available Los quistes de ovario son tumoraciones frecuentes en las afecciones ginecológicas. Se presenta el   caso de una paciente de 46 años de edad, que acudió al Hospital General Universitario Dr. Gustavo Aldereguía Lima, de Cienfuegos, refiriendo dolor y aumento de volumen del abdomen de un año de evolución. Se realizaron examenes físico y ultrasonográfico, mediante los que se le diagnosticó una masa quística dependiente de ovario. Se practicó laparotomía y se resecó un quiste de ovario izquierdo. En su estudio anatomopatológico se comprobó el diagnóstico de cistoadenoma seroso del ovario.

  6. Giant Ovarian Cyst: a Case Report Quiste gigante de ovario: presentación de un caso

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    Mario Joel Arroyo Díaz

    2011-11-01

    Full Text Available The giant cysts ovarian growths are rare in the gynecological conditions. We present the case of a patient of 62 years of age, of white color of the skin, weight 73 kg. He came to the General Teaching Hospital "Enrique Cabrera" referring volume increase progressive on the abdomen for a year and a half of evolution without another symptom companion in its beginning, but in recent months caused her lack of air before the efforts, urinated with more frequent than usual and with a lack of appetite. He was diagnosed with cystic mass dependent on ovary, by ultrasonography and computed axial tomography. The practical laparotomy and was resected ovarian cyst left from 21 kg in weight. The anatomopathological study further reported a mucinous cystadenoma ovarian tumor Brenner associated.Los quistes gigantes de ovario son tumoraciones poco frecuentes en las afecciones ginecológicas. Se presenta el caso de una paciente de 62 años de edad, de color de piel blanca, peso 73 kg. que acudió al Hospital General Docente “Enrique Cabrera” refiriendo aumento progresivo de volumen del abdomen, de un año y medio de evolución sin otro síntoma acompañante en su comienzo, pero en los últimos meses le provocaba falta de aire ante los esfuerzos, orinaba con más frecuencia de lo acostumbrado y con falta de apetito. Se le diagnosticó una masa quística dependiente de ovario, por ultrasonografía y Tomografía Axial Computarizada. Se practicó laparotomía y se resecó quiste de ovario izquierdo de 21 kg. de peso. El estudio anatomopatológico ulterior reportó un cistoadenoma mucinoso de ovario con tumor de Brenner asociado.

  7. Giant Ovarian Cyst. A Case Report Quiste de ovario gigante. Presentación de un caso

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    Yarisdey Corrales Hernández

    2012-09-01

    Full Text Available Ovarian cysts are common tumors among gynecological conditions. The case of a 46 years old woman who arrived at the Dr. Gustavo Aldereguía Lima General University Hospital in Cienfuegos, because of pain and swelling of the abdomen of a year of evolution is presented. The physical examination and ultrasound were performed and the patient was diagnosed with an ovarian dependant cystic mass. Laparotomy was performed and the left ovarian cyst was resected. In pathological and anatomical studies the diagnosis of an ovarian serous cystadenoma was confirmed.Los quistes de ovario son tumoraciones frecuentes en las afecciones ginecológicas. Se presenta el   caso de una paciente de 46 años de edad, que acudió al Hospital General Universitario Dr. Gustavo Aldereguía Lima, de Cienfuegos, refiriendo dolor y aumento de volumen del abdomen de un año de evolución. Se realizaron examenes físico y ultrasonográfico, mediante los que se le diagnosticó una masa quística dependiente de ovario. Se practicó laparotomía y se resecó un quiste de ovario izquierdo. En su estudio anatomopatológico se comprobó el diagnóstico de cistoadenoma seroso del ovario.

  8. Gigantism

    Science.gov (United States)

    ... growth has stopped, the condition is known as acromegaly . Gigantism is very rare. Symptoms The child will grow ... child has signs of excessive growth. Alternative Names ... Katznelson L, Laws ER Jr, Melmed S, et al. Acromegaly: an Endocrine Society clinical practice guideline. J Clin ...

  9. Quiste dentígeno gigante en una niña: Presentación de un caso Giant dentigerous cyst in a girl: Case report

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    Juan Carlos Quintana Díaz

    2007-06-01

    Full Text Available Se presenta un caso interesante de una niña de 13 años que acude a la consulta de Cirugía Maxilofacial por presentar asimetría facial y bucal, además de referir diplopia y obstrucción nasal del lado de la deformidad. Después de realizar exámenes de laboratorio, radiográficos y tomografía axial computadorizada (TAC, se lleva al salón de operaciones para realizar extracción del tercer molar superior izquierdo retenido en posición invertida, enuclear la extensa área radiolúcida a los rayos X y radiopaca a la tomografía y posteriormente se realiza estudio histopatológico. El diagnóstico definitivo corroboró el presuntivo (quiste dentígeno . La paciente evolucionó de forma excelente; desaparecieron la deformidad facial y los demás síntomas preoperatorios.An interesting case of a 13 year-old girl comes to Maxillofacial Surgery consultation because she has facial and buccal asymmetry; she also refers diplopia and nasal obstruction on the side of the deformity. After carrying out laboratory exams, radiographic studies and computerized axial tomography (TAC, she was taken to the operating room to receive an extraction of the third left superior molar retained in inverted position, and to have retrieved the extensive rays- X radiolucid and radiopaque area at tomography and later on she underwent a histopathological study. The definitive diagnosis corroborated the presumption of dentition cyst. The patient evolved in an excellent way; her facial deformity and other preoperative symptoms disappeared.

  10. Adenoma paratiroideo. Presentación de un caso

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    Daniel Olivera Fajardo

    2016-10-01

    Full Text Available El adenoma paratiroideo es un tumor no canceroso de las glándulas paratiroides, que aumenta los niveles de parathormona. Esta hormona regula los niveles de calcio, fósforo y vitamina D en sangre y huesos. Su triada clásica se caracteriza por aumento de los niveles de parathormona, hipercalcemia e hipofosfatemia. Esta entidad afecta a uno entre 500-1000 habitantes y es la causa principal de hiperparatiroidismo primario en un 80- 85 % de los pacientes. Se presenta el caso de una paciente femenina de 69 años de edad, ingresada por fracturas patológicas de cadera, clavícula y dedos de las manos, causada por hiperparatiroidismo primario originado por adenoma paratiroideo. Por la baja incidencia esta entidad, su publicación se considera de interés para el personal científico.

  11. Quiste epidermoide del ciego

    OpenAIRE

    YAMANAKA,WATARU; Llamosas B,Fernando; Adorno R,Hugo

    2012-01-01

    Quiste epidermoide es un saco con características benignas que se origina del ectodermo embrionario. Histológicamente consiste en una delgada capa de epitelio escamoso. Quistes epidermoide de ciego son excepcionalmente raros. Reportamos un caso de quiste epidermoide en pared anterior del ciego en una paciente sin cirugía previa y realizamos una revisión de lo publicado sobre esta patología.

  12. Quiste suprarrenal primario

    OpenAIRE

    Cabané T,Patricio; Gac M,Patricio; Mariño B,Jorge; IBACACHE A,DANIELA; Ledezma S,Alejandra; Morales H,Claudia

    2011-01-01

    Los quistes suprarrenales son las lesiones quísticas más frecuentes de la glándula suprarrenal, a pesar de que constituyen una rara entidad. Típicamente se presentan por un cuadro de dolor abdominal o masa palpable, pero en la actualidad se detectan cada vez con más frecuencia en estudios radiológicos como incidentalomas. Los quistes suprarrenales cuentan con amplios diagnósticos diferenciales, lo que hace un difícil diagnóstico definitivo y una dificultad en el manejo posterior. Estos quiste...

  13. Quistes de los maxilares

    OpenAIRE

    Ivan Alberto Manotas Arevalo

    2013-01-01

    Los Grandes Quistes de los Maxilares han estado vinculados siempre a la humanidad, desde tiempos remotos, pues han sido halladas en restos de especimenes fosiles, han llamado la atencion de los clínicos, en torno a su etiologia, en la que se ha introducido la participacion de la genetica, (demostrada en el desarrollo de los queratoquistes maxilares), la fisiopatologia, caracteristicas histologicas (inmunohistoquimica), posibilidades diagnosticas por la imagen, (como la tomografia computarizad...

  14. Quiste dermoide cervical

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    Yurian Gbenou Morgan

    Full Text Available Los quistes dermoides presentan una incidencia de 1,6 hasta 6,9 % en la región de cabeza y cuello. Se realiza el siguiente reporte de caso clínico con el objetivo de enfatizar en la importancia de un adecuado manejo diagnóstico preoperatorio, para establecer una acertada planificación quirúrgica en la exéresis de este tipo de lesiones de la región cervicofacial. Se presenta el caso clínico de un paciente masculino, de 13 años de edad, quien hacía 3 años se notaba un crecimiento redondeado en región submentoniana, lo cual le ocasionaba molestias al hablar y ligera afectación de su estética facial. Una vez realizados los estudios complementarios preoperatorios, se decide tratamiento quirúrgico, empleando una cervicotomía medial para la extirpación de la lesión quística, dada la ubicación anatómica por debajo del músculo milohiodeo y su gran dimensión. El diagnóstico histopatológico se corresponde con un quiste epidérmico. Se concluye que resulta imprescindible realizar un exhaustivo examen físico e imagenológico, para lograr resultados satisfactorios en el tratamiento quirúrgico del quiste dermoide cervical.

  15. Quistes de los maxilares

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    Ivan Alberto Manotas Arevalo

    2013-12-01

    Full Text Available Los Grandes Quistes de los Maxilares han estado vinculados siempre a la humanidad, desde tiempos remotos, pues han sido halladas en restos de especimenes fosiles, han llamado la atencion de los clínicos, en torno a su etiologia, en la que se ha introducido la participacion de la genetica, (demostrada en el desarrollo de los queratoquistes maxilares, la fisiopatologia, caracteristicas histologicas (inmunohistoquimica, posibilidades diagnosticas por la imagen, (como la tomografia computarizada y la resonancia nuclear magnetica y otras pruebas. Además llaman la atención al estudio, por sus alternativas de manejo especialmente las formas radicales, y el analisis de asociaciones a otras patolo-gias benignas y malignas, y de la recurrencia muy alto de algunas de estas lesiones. Mucho se ha desarrollado para elucidar su naturaleza real, estadificar adecuadamente la lesion descartando asocia-ciones patologicas sindromicas, indicar un tratamiento apropiado, y realizar seguimientos a largo plazo. Este articulo pretende recaudar una information general que de parametros para abordar el estudio de los quistes maxilares a partir de la presentacion de un caso clinico.

  16. Quiste Tímico

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    IsnerioValerio Arzuaga Anderson

    2001-06-01

    Full Text Available Los quistes tímicos son lesiones poco frecuentes. La mayoría se presenta en las primeras décadas de la vida, aunque pueden estar presentes desde el nacimiento. Otros se descubren incidentalmente en radiografías torácicas y autopsias y pueden confundirse con tumores malignos. Se reporta 1 caso, con hemorragia antigua y granulomas de colesterol, en el estudio necrópsico de una anciana de 71 años de edad, localizado en la porción anterosuperior del mediastino, no relacionado con su fallecimiento, el cual fue por infarto miocárdico agudo. El estudio histológico de la pieza reveló la naturaleza tímica del proceso. Se discuten los aspectos microscópicos del caso y se precisa su diagnóstico diferencial con otros tumores del mediastinoThymic cysts are uncommon lesions. Most of them occur in the first decade of life, although they may be present at birth. Other thymic cysts are incidentally discovered in chest X-rays and in autopsy and may be mistaken for malignant tumors. It is reported the case of a woman aged 71 with an old hemorrhage and cholesterol granuloma detected by necropsy study, where a cyst was located in the mediastinum anteroposterior portion.. It was not related to her death, since she died from acute myocardial infarction. The histologic study of the cyst revealed the thymic nature of the process. The microscopic features of the case are discussed and its differential diagnosis is specified in relation to other mediastinal tumors

  17. Carcinoma papilar de tiroides en quiste tirogloso

    OpenAIRE

    MOLANO G,JULIÁN ANDRÉS; ROSSEL DE LA M,GONZALO; González P,Miguel; PLASS DEL C,INGRID

    2013-01-01

    Objetivo: Reportar un caso raro de carcinoma papilar en un quiste tirogloso y discutir su manejo. Paciente y Método: Un hombre de 72 años a quien se realizó un diagnóstico clínico de un quiste tirogloso, fue llevado a una cirugía de Sistrunk's y luego una tiroidectomía total ante la evidencia de cáncer papilar en el quiste tirogloso. Resultados: El examen histopatológico reveló un carcinoma papilar de tiroides en el quiste tirogloso y la glándula tiroides fue normal, el paciente permaneció li...

  18. Condiloma gigante

    OpenAIRE

    Brunno Cezar Framil Sanches; Lineu Amaro Rodrigues Júnior; Felipe Trentin Neves; Thiago Correa Tambelli; Fernando Eduardo Paulatti Frederico; Fátima Mohamad All Haj; Juliana Monteiro de Abreu; Tatiana Milunovic Lobo Rosa; Alexis Iury Framil Sanches; Antonio Alberto Ramos Argento

    2011-01-01

    O condiloma gigante está altamente associado à infecção pelo Papiloma Vírus Humano (HPV), uma das doenças sexualmente transmissíveis mais prevalentes no mundo. Paciente de 54 anos, com aparecimento de lesão vegetante em região suprapúbica de crescimento progressivo há 20 anos. Realizou tratamento prévio de condiloma peniano com cauterização com sucesso. A lesão teve crescimento significativo e foi, então, submetido à biópsia com diagnóstico histológico de condiloma acuminado. A terapia eleita...

  19. Hidrocele gigante en paciente anciano

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    Ada Arleny Pérez Mayo

    2014-09-01

    Full Text Available Se presenta el caso de un paciente de 87 años, intervenido por primera vez en el Hospital Nacional “San Pedro Necta” del Departamento de Huehuetenango en Guatemala, por presentar hidrocele gigante de más de veinte años de evolución. El examen físico mostró tumoración translúcida dolorosa en la bolsa escrotal izquierda, con el posible diagnóstico de hidrocele tabicado o no comunicante. El preoperatorio consistió en la canalización de vena periférica, administración de profilaxis antibiótica con ceftriaxona y rasurado de la piel. Durante el acto operatorio se constató hidrocele izquierdo, con acumulación de líquido acuoso de la túnica vaginal que rodeaba el testículo, cuantificable alrededor de los 500 ml. La técnica quirúrgica consistió en la eversión o plicatura de la vaginal. No se presentaron entidades asociadas, como quiste del cordón, hernia inguinal o fimosis. No existieron complicaciones. Se reportó una estadía hospitalaria de cuatro días y el paciente evolucionó favorablemente. No ocurrió recidiva durante el año de seguimiento

  20. Condiloma gigante

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    Brunno Cezar Framil Sanches

    2011-09-01

    Full Text Available O condiloma gigante está altamente associado à infecção pelo Papiloma Vírus Humano (HPV, uma das doenças sexualmente transmissíveis mais prevalentes no mundo. Paciente de 54 anos, com aparecimento de lesão vegetante em região suprapúbica de crescimento progressivo há 20 anos. Realizou tratamento prévio de condiloma peniano com cauterização com sucesso. A lesão teve crescimento significativo e foi, então, submetido à biópsia com diagnóstico histológico de condiloma acuminado. A terapia eleita foi a exérese completa da lesão. A terapia invasiva se torna opção terapêutica de eleição, indicada por todos os estudos analisados. No caso em questão, a opção terapêutica foi a retirada completa da lesão devido à recorrência do quadro após terapias de cauterização química e térmica. Apesar de a abordagem cirúrgica ser uma conduta mais agressiva, no paciente em questão foi adequada por conta do tamanho e da falha de terapias anteriores.

  1. Quiste del mesenterio intestinal en la edad pediátrica

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    Ada Arleny Pérez Mayo

    2014-08-01

    Full Text Available Se presenta el caso de una paciente de 9 años de edad, ingresada por molestia abdominal en el Hospital Nacional de San Pedro Necta del Departamento de Huehuetenango, en Guatemala. Constituyó una rara lesión intra-abdominal, que pudo provocar abdomen agudo. Fue interpretado inicialmente como quiste de ovario gigante. La ausencia de ecografía abdominal y la presencia de distensión y masa palpable asintomática decidieron la intervención quirúrgica. Se realizó una cuidadosa preparación preoperatoria, que incluyó la antisepsia local de la piel y la administración de ceftriaxona, como antibiótico profiláctico. Durante la laparotomía exploradora se constató un quiste gigante del mesenterio del intestino delgado, de 17 cm de longitud, localizado a nivel del íleon terminal y sujeto por un pedículo ampliamente vascularizado. La técnica quirúrgica consistió en la exéresis total de la lesión y no se requirió de resección intestinal ante la ausencia de oclusión intestinal. Los hallazgos anatomo-patológicos informaron proceso benigno. No se reportaron complicaciones y la paciente evolucionó satisfactoriamente, reportándose una estadía hospitalaria de cinco días

  2. Quiste dermoide del suelo de la boca

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    Ayelén María Portelles Massó

    2010-12-01

    Full Text Available El quiste dermoide representa menos del 0,01 % de todos los quistes de la cavidad bucal. Su ubicación más frecuente es en suelo de boca. Se presenta el caso de una paciente femenina de 19 años de edad que hacía aproximadamente 7 años había notado un aumento de volumen debajo de la lengua, el cual le crecía paulatinamente y ya se apreciaba por fuera de la cara. Además, le ocasionaba molestias al hablar y al masticar. Se realizaron estudios complementarios y bajo anestesia general nasotraqueal. Se procedió a su exéresis quirúrgica mediante un abordaje intrabucal, donde se obtuvieron excelentes resultados estéticos y funcionales. El diagnóstico histopatológico se correspondió con un quiste dermoide de suelo de boca. La paciente no ha tenido recurrencia de la lesión transcurridos tres años de la operación. El quiste dermoide de suelo de boca se presenta como una tumoración benigna de la línea media. La exéresis intrabucal demuestra beneficios estéticos y funcionales.

  3. [Gigantism: a mystery explained].

    Science.gov (United States)

    Beckers, Alb

    2002-01-01

    Acromegaly was first described by Pierre Marie in 1886. Some years later, it became clear that acromegaly and gigantism share the same etiology: GH hypersecretion due to a pituitary adenoma, induces gigantism if already present during puberty, or an acromegalic if it appears only during the adulthood. During the XXth century, the disease has been well described and is now well controlled with several treatments. Recently, genetic alterations responsible for the disease have been elucidated.

  4. Hiperparatiroidismo secundario a adenoma paratiroideo mediastinal Hyperparathyroidism due to mediastinal parathyroid adenoma

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    C Agostinis

    2012-03-01

    Full Text Available Las glándulas paratiroides se localizan en el cuello, en la cara posterior de la glándula tiroides. Tienen como función secretar PTH, la cual está regulada por la concentración extracelular de calcio. Se define como hiperparatiroidismo a la producción excesiva de PTH por las glándulas paratiroideas, siendo el 85 % aproximadamente de los casos producto de un adenoma; un 12 % debido a hiperplasia y menos del 1 % por carcinomas. El hiperparatiroidismo primario ectápico se presenta en el 10 % de los pacientes, de los cuales del 1 al 2 % corresponde a la localización mediastinal(1. Presentamos una paciente de 38 años, internada en nuestra institución por hipercalcemia sintomática, comprobándose niveles plasmáticos elevados de PTH. Se le realizá una gammagrafía con tecnecio 99 MIBI que evidenció una imagen hipercaptante a nivel de mediastino anterior. Fue intervenida quirúrgicamente, obteniendo como resultado de la anatomía patolágica un adenoma paratiroideo.The parathyroid glands are located in the neck, on the back of the thyroid gland. Their function is to secrete PTH, which is regulated by extracellular calcium concentration. Hyperparathyroidism is defined as the excessive production of PTH by the parathyroid glands; approximately 85 % of the cases are caused by an adenoma, 12 % due to hyperplasia and less than 1 % by carcinomas. Ectopic Primary hyperparathyroidism occurs in 10 % of the patients, of which from 1 to 2 % are of mediastinal location(1. We report the case of a 38-year-old patient hospitalized in our institution for symptomatic hypercalcemia. During her hospitalization elevated plasma levéis of PTH were found with image MIBI technetium 99 high uptake in the anterior mediastinum. She underwent surgery, and the pathology report showed parathyroid adenoma.

  5. Quiste enterogénico de mediastino posterior

    OpenAIRE

    Ledesma, M. D.; Zurmann, Pamela; Cantil, A. C.; Picabea, S. M.; Chico, H. M.; Gioiosa, M. A.; Villegas Bogoni, F. D.; Aguilera, R. A.

    2016-01-01

    Los aparatos respiratorio y digestivo tienen un origen común en el intestino primitivo, motivo por el cual los quistes derivados de aquellos, broncogénicos y entéricos o de duplicación, se denominan conjuntamente quistes enterogénicos. Son malformaciones producidas durante el período de diferenciación y desarrollo embriológico de dicho intestino primitivo. En el tórax, los quistes entéricos representan el 20% de las duplicaciones del tubo digestivo.El 60% de los quistes entéricos se diagnosti...

  6. Quiste dermoide verdadero en piso de boca

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    Daniel Antunes Freitas

    Full Text Available Los quistes dermoides son lesiones benignas de origen embrionario, con una incidencia del 0,01 % de todos los quistes de la cavidad bucal. No presenta predicción por sexo y alrededor del 60 % de los casos se desarrollan entre los 15 y 35 años de edad. El conocimiento de los hallazgos clínicos de este tipo lesiones es vital para un diagnóstico definitivo, sin embargo, este siempre debe ser corroborado mediante exámenes histopatológicos, especialmente, al realizar un diagnóstico diferencial entre los diferentes tipos de quiste dermoides u otras alteraciones a nivel oral con manifestaciones clínicas similares. El propósito de esta presentación reportar un caso clínico para ampliar conocimientos sobre el diagnóstico y tratamiento de este tipo de lesión debido a su infrecuencia en cavidad oral. La ubicación inusual de estos quistes en cavidad oral hace que, aún con una buena valoración clínica e imaginológica, el diagnóstico prequirúrgico preciso sea difícil. Es por esto que el tratamiento quirúrgico no sólo evita el riesgo de una complicación infecciosa y eventual malignización sino que permite obtener un diagnóstico definitivo mediante estudios histopatológicos.

  7. AIP mutations and gigantism.

    Science.gov (United States)

    Rostomyan, Liliya; Potorac, Iulia; Beckers, Pablo; Daly, Adrian F; Beckers, Albert

    2017-06-01

    AIP mutations are rare in sporadic acromegaly but they are seen at a higher frequency among certain specific populations of pituitary adenoma patients (pituitary gigantism cases, familial isolated pituitary adenoma (FIPA) kindreds, and patients with macroadenomas who are diagnosed ≤30 years). AIP mutations are most prevalent in patients with pituitary gigantism (29% of this group were found to have mutations in AIP gene). These data support targeted genetic screening for AIP mutations/deletions in these groups of pituitary adenoma patients. Earlier diagnosis of AIP-related acromegaly-gigantism cases enables timely clinical evaluation and treatment, thereby improving outcomes in terms of excessive linear growth and acromegaly comorbidities. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  8. Quiste óseo aneurismático de los maxilares. Caso clínico. Instituto Nacional de Enfermedades Neoplásicas

    OpenAIRE

    Román Pilco, Sandra; Sánchez Lihón, Juvenal

    2004-01-01

    El quiste óseo aneurismático (QOA) de los maxilares es una lesión benigna intraósea compuesta por espacios cavernosos llenos de sangre, de tamaños variables, sin recubrimiento endotelial, asociados con tejido conectivo fibroso conteniendo células gigantes multinucleadas y tejido osteoide; clínicamente el lado afecto de los maxilares aumenta de tamaño y muestra una discreta inflamación. Puede haber ligero dolor a la palpación y donde pueden faltar o desplazarse ...

  9. Quiste hidatídico cerebral en niños en el Hospital Nacional Cayetano heredia: a propósito de un caso

    Directory of Open Access Journals (Sweden)

    Daniel Guillén

    1994-06-01

    Full Text Available Se presenta el caso de una niña de 12 años de edad con siete meses de evolución de signos focales e hipertensión endocraneana progressiva. Con ayuda de la TAC se diagnosticó tumoración quística gigante compatible a hidatidosis cerebral. Se realizó craneotomía y extirpación del quiste sin complicaciones. La hidatidosis cerebral es rara, su diagnóstico es clínico-tomográfico y el tratamiento siempre es quirúrgico.

  10. Quiste sacro de líquido cefalorraquídeo (quiste de Tarlov)

    National Research Council Canada - National Science Library

    Pérez-López, J; Ruiz-Pombo, M; Solans-Laque, R

    2005-01-01

    ... cefalorraquídeo (quiste de Tarlov). Servicio de Medicina Interna. Hospital Vall d’Hebron. Barcelona. España. Cortesía de los Dres. J. Pérez-López, M. Ruiz-Pombo y R. Solans-Laque. 71.810 IMAGEN DE LA SEMANA...

  11. Quiste retroperitoneal: Reporte de un caso

    OpenAIRE

    2012-01-01

    Los quistes retroperitoneales son tumoraciones benignas o malignas originadas en el espacio retroperitoneal, la gran mayoría de ellos presentan características de benignidad, predominan en el sexo femenino y se clasifican fundamentalmente en base a su tejido de origen. El tratamiento depende de la histopatología, sin embargo la mayoría de los autores coinciden en realizar resección quirúrgica. Se presenta el caso de paciente femenina de 48 años de edad quien acude a consulta por presentar dol...

  12. Pulsars: Gigantic Nuclei

    CERN Document Server

    Xu, Renxin

    2011-01-01

    What is the real nature of pulsars? This is essentially a question of the fundamental strong interaction between quarks at low-energy scale and hence of the non-perturbative quantum chromo-dynamics, the solution of which would certainly be meaningful for us to understand one of the seven millennium prize problems (i.e., "Yang-Mills Theory") named by the Clay Mathematical Institute. After a historical note, it is argued here that a pulsar is very similar to an extremely big nucleus, but is a little bit different from the {\\em gigantic nucleus} speculated 80 years ago by L. Landau. The paper demonstrates the similarity between pulsars and gigantic nuclei from both points of view: the different manifestations of compact stars and the general behavior of the strong interaction.

  13. Quiste coloide del tercer ventrículo

    OpenAIRE

    Juan Dávila Meneses

    2012-01-01

    Los quistes coloides son lesiones intracraneales con una incidencia calculada en tres individuos por millón de personas en un año. Son tumores benignos de la porción anterosuperior del tercer ventrículo. El flujo normal del líquido cefalorraquídeo puede ser interrumpido por un gran quiste que obstruya el foramen de Monro. Los signos y síntomas asociados engloban un espectro amplio de características, desde una cefalea no específica hasta datos de hipertensión intracraneal; algunos quistes col...

  14. Quiste radicular de origen odontogénico

    OpenAIRE

    Posada Álvarez, Juan David

    2014-01-01

    El quiste radicular es el más común de los quistes odontogénicos presentes en los maxilares, cuya incidencia varía entre 52 y 75%; constituyen del 6 al 55% de las lesiones pulpoperiapicales.El 9% corresponde a quistes verdaderos, cuya resolución se logra mediante tratamiento endodóntico convencional. La mayor frecuencia se presenta en mujeres y en edad adulta.Algunos autores reportan que no existe preferencia de edad ni sexo; otros reportan que esta lesión es más frecuente en el sexo masculin...

  15. Quiste dentígero en niños

    OpenAIRE

    Fernanda Astrogilda de Sousa Feitosa; Amanda Simião Figueiredo; Carolina Carvalho de Oliveira Santos; Bertha Angélica Chávez Gonzalez; Raquel Gonçalves Vieira-Andrade; Thiago Fonseca-Silva

    2016-01-01

    Introducción: El quiste dentígero es el segundo tipo de quistes odontogénicos más frecuentes de los maxilares, desarrollándose a partir de alteraciones del epitelio del órgano del esmalte, donde ocurre una acumulación de líquido entre el epitelio y el esmalte. Por lo general está relacionado a la corona de un diente no erupcionado. Objetivos: el objetivo de este estudio fue analizar los aspectos de diagnóstico y tratamiento de los quistes dentígero en pacientes pediátricos. Métodos: se realiz...

  16. Mielolipoma suprarrenal gigante

    OpenAIRE

    GAC E,PATRICIO; CABANÉ T,PATRICIO; Klein P,Eulin; Seymur M,Camila; Segura H,Paula

    2012-01-01

    Los mielolipomas son tumoraciones benignas poco frecuentes con mayor localización en las glándulas suprarrenales. Su tamaño puede variar desde unos pocos milímetros hasta varias decenas de centímetros y dependiendo del tamaño pueden llegar a ser sintomáticos. Se presenta el caso de un paciente masculino de 49 años al que incidentalmente se le diagnostica un mielolipoma suprarrenal derecho gigante de 22 x 15 x 10 cm.

  17. Quiste de erupcion en denticion mixta

    Directory of Open Access Journals (Sweden)

    Mileydis Esther Fernández Munive

    2013-10-01

    Full Text Available Title: Cyst of eruption in mixed dentition.ResumenLos quistes de erupción se presentan como áreas en la mucosa de levantamiento de volumen blando, de diferente coloración: azulado, rojo, vinaceo; mantiene un vaso presionado del que no solo sale agua, sino también sangre. Determinado como una variante del quiste dentígero, de origen odontogénico epitelial, diferentes porque este existe dentro del hueso; habitualmente en asociación con dientes próximos a erupcionar y en su gran mayoría relacionados con dentición mixta. En este caso clínico expuesto, la relación es con la erupción del diente 44, se muestra el abordaje y el control posoperatorio en el cual demuestra a través de fotografías la erupción adecuada del diente. (DUAZARY 2012 No. 2, 196 - 200AbstractThe cysts of eruption appear as areas in the mucous one of raising of soft volume, of different coloration: bluish, red, vinaceo; it keeps a glass pressed of the one that not only goes out waters down, but also bleed. Determined as a variant of the cyst dentígero, of origin odontogénic epitelial, different because this one exists inside the bone; habitually in association with near teeth to erupcionar and in his great majority related to mixed dentition. In this clinical exposed case, the relation is with the eruption of the tooth 44, the boarding and the control appears posoperatorio in which it demonstrates across photographies the suitable eruption of the tooth.Keywords: Tooth eruption; Odontogenic Cysts; Dentition Mixed. (MeSH.

  18. Quiste retroperitoneal: Reporte de un caso

    Directory of Open Access Journals (Sweden)

    Néstor Moisés Tineo Araque

    2010-01-01

    Full Text Available Los quistes retroperitoneales son tumoraciones benignas o malignas originadas en el espacio retroperitoneal, la gran mayoría de ellos presentan características de benignidad, predominan en el sexo femenino y se clasifican fundamentalmente en base a su tejido de origen. El tratamiento depende de la histopatología, sin embargo la mayoría de los autores coinciden en realizar resección quirúrgica. Se presenta el caso de paciente femenina de 48 años de edad quien acude a consulta por presentar dolor persistente en hemiabdomen derecho, a la evaluación paraclínica con ultrasonido abdominal se evidenció tumor quístico en flanco derecho de 12 por 14 centímetros. La tomografía axial computarizada reportó imagen retroperitoneal que se extiende desde la fosa ilíaca derecha hasta hipocondrio derecho. Se realizó laparotomía exploradora, hallándose quiste de retroperitoneo de 15 por 20 centímetros con cápsula definida y de contenido líquido (de consistencia gelatinosa que se clasifica posteriormente como un hamartoma retroperitoneal. Debido a su baja incidencia, el conocimiento y estudio de este tipo de patología se ha visto truncada en la práctica médica, razón por la cual es de difícil diagnóstico trayendo como consecuencia que en muchos casos el paciente es ingresado a quirófano con un diagnóstico errado.

  19. Quiste dentígero en niños

    Directory of Open Access Journals (Sweden)

    Fernanda Astrogilda de Sousa Feitosa

    2016-01-01

    Full Text Available Introducción: El quiste dentígero es el segundo tipo de quistes odontogénicos más frecuentes de los maxilares, desarrollándose a partir de alteraciones del epitelio del órgano del esmalte, donde ocurre una acumulación de líquido entre el epitelio y el esmalte. Por lo general está relacionado a la corona de un diente no erupcionado. Objetivos: el objetivo de este estudio fue analizar los aspectos de diagnóstico y tratamiento de los quistes dentígero en pacientes pediátricos. Métodos: se realizó una búsqueda de artículos científicos indexados en la base de datos bibliográficos PUBMED® en el período comprendido entre febrero y marzo de 2015, mediante el descriptor "dentigerous cyst". Resultados: Se encontraron 147 artículos publicados en los últimos 10 años. Todos los artículos que trataban sobre quiste dentígero en niños fueron incluidos en este estudio. La literatura revisada destaca puntos importantes sobre la epidemiología, manejo y tratamiento de quiste dentígero en pacientes pediátricos. Conclusión: De los artículos revisados se puede concluir que el quiste dentígero es más frecuente en los niños del género masculino y con una edad media de 10 años. Afecta principalmente a la mandíbula y tanto la enucleación como la marsupialización están indicados para el tratamiento de quistes

  20. Linfedema escrotal gigante

    Directory of Open Access Journals (Sweden)

    C. Carrasco López

    2013-06-01

    Full Text Available La elefantiasis escrotal es una condición que ha sido historicamente descrita en áreas endémicas de filariasis, siendo menos frecuente su presentación idiopática o asociada a otras entidades. Presentamos un caso de elefantiasis escrotal gigante de causa adquirida al que se le practicó exéresis de estructura linfadematosa con reconstrucción con colgajo local y autoinjerto cutáneo. El caso clínico presentado es raro, ya sea por la baja frecuencia o por su etiología, así como por la importante magnitud del problema. Por esta razón hemos decidido presentarlo para dar a conocer posibilidades terapéuticas y realizar una revisión del tema.

  1. Quiste óseo simple de cóndilo mandibular

    OpenAIRE

    Julio Cifuentes; Ariel Barrera; Daniel Jerez; Stephanie Bohmann

    2015-01-01

    El quiste óseo simple (QOS) es una entidad descrita por primera vez por Lucas en 1929. En 1946, Rushton describió las paredes internas del quiste que consistían en tejido óseo sin contenido patológico o químico. Esta entidad intraósea también es conocida con múltiples sinónimos como quiste óseo solitario, quiste óseo traumático, quiste óseo hemorrágico, quiste unicameral, cavidad ósea idiopática y cavidad o quiste óseo progresivo. Cuando afecta a los maxilares suelen ser asintomáticos, siendo...

  2. Genetics of gigantism and acromegaly.

    Science.gov (United States)

    Hannah-Shmouni, Fady; Trivellin, Giampaolo; Stratakis, Constantine A

    Gigantism and acromegaly are rare disorders that are caused by excessive GH secretion and/or high levels of its mediator, IGF-1. Gigantism occurs when excess GH or IGF-1 lead to increased linear growth, before the end of puberty and epiphyseal closure. The majority of cases arise from a benign GH-secreting pituitary adenoma, with an incidence of pituitary gigantism and acromegaly of approximately 8 and 11 per million person-years, respectively. Over the past two decades, our increasing understanding of the molecular and genetic etiologies of pituitary gigantism and acromegaly yielded several genetic causes, including multiple endocrine neoplasia type 1 and 4, McCune-Albright syndrome, Carney complex, familial isolated pituitary adenoma, pituitary adenoma association due to defects in familial succinate dehydrogenase genes, and the recently identified X-linked acrogigantism. The early diagnosis of these conditions helps guide early intervention, screening, and genetic counseling of patients and their family members. In this review, we provide a concise and up-to-date discussion on the genetics of gigantism and acromegaly. Published by Elsevier Ltd.

  3. Presentación de un caso de quiste hepático simple tratado por cirugía mínima invasiva Report of a case with simple hepatic cyst treated by minimally invasive surgery

    Directory of Open Access Journals (Sweden)

    Iris Soberón Varela

    2007-12-01

    Full Text Available Se describió el caso de una paciente con un quiste hepático simple gigante, afección poco frecuente que usualmente es asintomática y resulta de un hallazgo imaginológico. Cuando el quiste alcanza un tamaño mayor de 5cm comienza a producir manifestaciones clínicas, como ocurrió en el caso que presentamos, el cual pudo ser tratado de forma exitosa por cirugía mínima invasiva. La confirmación anatomopatológica fue de un quiste hepático simple.The case of a patient with giant simple hepatic cyst, a rare affection that is usually asymptomatic and results from an imaging finding, was described. When the cyst reaches a size over 5 cm, it starts to produce clinical manifestations, as in the case under study, that was successfully treated by minimally invasive surgery. A simple hepatic cyst was anatomopathologically confirmed.

  4. Distensión abdominal y edemas por quiste del cordón espermático Abdomina distention and edema due to spermatic cord cyst

    Directory of Open Access Journals (Sweden)

    Guillermo A. Keller

    2006-04-01

    Full Text Available La distensión abdominal es un síntoma común, siendo en general la presentación inicial de enfermedades sistémicas o desórdenes gastrointestinales. Otras causas son infrecuentes. Los quistes del cordón espermático son poco frecuentes, pero aún más su ubicación intraabdominal, su tamaño habitual es insuficiente para producir distensión. El paciente presentado en este caso es un varón con criptorquidia bilateral admitido por distensión abdominal, interpretada inicialmente como síndrome ascítico edematoso. La ecografía interpretó la distensión como ascitis tabicada, y la tomografía computada como debida a un gran quiste. En la exploración quirúrgica se diagnosticó un quiste gigante del cordón espermático de ubicación abdominal.Abdominal distention is a frequent symptom, being often the initial presentation of systemic diseases or gastrointestinal disorders. Other causes are uncommon. Spermatic cord cysts are infrequent, abdominal location is even rarer, and the size of the cysts is usually not enough to produce abdominal distention. In our case a man with bilateral cryptorchidism was admitted with abdominal distention and edema of the lower extremities initially interpreted as ascitic-edematous syndrome. Ultrasonography interpreted abdominal distention as septate ascites, computed tomography as a giant cyst. Exploratory surgery showed a giant spermatic cord cyst in the left spermatic cord.

  5. Quiste dermoide en la cola de la ceja

    Directory of Open Access Journals (Sweden)

    Lázara Kenia Ramírez García

    Full Text Available El quiste dermoide es un tipo de coristoma que corresponde a una anomalía congénita del desarrollo. Se presenta una transicional de dos años. Desde su nacimiento, la mamá notó un aumento de volumen a nivel de la cola de la ceja del ojo derecho, de bordes delimitados, blanda, movible, reborde orbitario libre, sin cambios de coloración, con un crecimiento acelerado clínico y ultrasonográfico en meses. Se decidió exéresis y biopsia para estudio anatomopatológico. Los resultados finales mostraron confirmación del diagnóstico de quiste dermoide en la cola de la ceja. La evolución posoperatoria fue satisfactoria sin recidiva de la lesión.

  6. Quistes gingivales y palatinos del recién nacido

    National Research Council Canada - National Science Library

    Monteagudo, Benigno; Romarís, Rosa; León-Muiños, Elvira; Corrales, Alba; Carballeira, Iria; Ramírez-Santos, Aquilina; Fernández-Prieto, Ramón

    2010-01-01

    ... y su posible confusión con dientes congénitos 5–7 . Aunque fueron descritos por Bohn en 1866 y Epstein en 1880, su nomenclatura y clasificación ha sido confusa hasta hace pocos años. Epidemiología En los RN sanos el hallazgo más frecuente en la cavidad oral son los quistes palatinos y alveolares. Su prevalencia oscila entre el 60–90%. Es...

  7. Pituitary gigantism: Causes and clinical characteristics.

    Science.gov (United States)

    Rostomyan, Liliya; Daly, Adrian F; Beckers, Albert

    2015-12-01

    Acromegaly and pituitary gigantism are very rare conditions resulting from excessive secretion of growth hormone (GH), usually by a pituitary adenoma. Pituitary gigantism occurs when GH excess overlaps with the period of rapid linear growth during childhood and adolescence. Until recently, its etiology and clinical characteristics have been poorly understood. Genetic and genomic causes have been identified in recent years that explain about half of cases of pituitary gigantism. We describe these recent discoveries and focus on some important settings in which gigantism can occur, including familial isolated pituitary adenomas (FIPA) and the newly described X-linked acrogigantism (X-LAG) syndrome.

  8. Quiste coloide del tercer ventrículo

    Directory of Open Access Journals (Sweden)

    Juan Dávila Meneses

    2012-09-01

    Full Text Available Los quistes coloides son lesiones intracraneales con una incidencia calculada en tres individuos por millón de personas en un año. Son tumores benignos de la porción anterosuperior del tercer ventrículo. El flujo normal del líquido cefalorraquídeo puede ser interrumpido por un gran quiste que obstruya el foramen de Monro. Los signos y síntomas asociados engloban un espectro amplio de características, desde una cefalea no específica hasta datos de hipertensión intracraneal; algunos quistes coloides se dan en el comienzo agudo de una hidrocefalia y pueden llevar a una muerte súbita. Caso: presentamos el caso de un adolescente masculino de 13 años de edad, de raza negra, quien dos días antes de su fallecimiento había manifestado cefalea. Al examen de autopsia se evidenció un quiste coloide del tercer ventrículo que produjo una hidrocefalia aguda obstructiva, con edema cerebral severo y herniación de amígdalas cerebelosas. En este artículo comentamos las características principales del quiste coloide y realizamos una breve revisión bibliográficaColloid cysts are intracranial lesions with an estimated incidence of three individuals per million people per year. They are benign tumors of the anterior portion of the third ventricle. The normal flow of cerebrospinal fluid may be interrupted by a large cyst obstructing the foramen of Monro. The signs and symptoms associated cover a wide range of features, from a non-specific headaches to intracranial hypertension data, some colloid cysts occur in the acute onset of hydrocephalus and can lead to sudden death. Case: We present the case of an adolescent male 13 years of age, black race, who two days before his death had expressed headache. On examination autopsy showed a third ventricular colloid cyst that caused acute obstructive hydrocephalus with severe cerebral edema and herniation of cerebellar tonsils. In this article we discuss the main features of the colloid cyst and performed

  9. Quistes de los maxilares en el Servicio de Cirugía Maxilofacial de Artemisa

    Directory of Open Access Journals (Sweden)

    Juan Carlos Quintana Díaz

    2014-07-01

    Full Text Available Los quistes representan una de las principales causas de destrucción de los maxilares. La información relativa a estas entidades en la población cubana es escasa, por esto el propósito de la presente investigación es el presentar la frecuencia de los distintos tipos de quistes registrados en el servicio de cirugía máxilofacial en la ciudad de Artemisa, asícomo comparar los hallazgos con lo reportado en otros estudios y analizar su posible asociación con el sexo de los afectados y el tipo de diagnóstico histopalógico. Se registraron 172 quistes, de los cuales 87 (50.6% se presentaron en mujeres, 85 (49.4%en hombres. Se identificaron 9 variedades de quistes de las entidades reconocidas por la OMS. Los quistes más frecuentes fueron: quiste radiculares periapicales (104 casos, el quiste residual (24 casos y quiste dentígero (19 casos. En conjunto, estas tres entidades representaron el 85.4% del total. La localización mas frecuente fue la mandíbula. El conocer el origen, los aspectos clínico–patológicos y la conducta biológica de estaslesiones son aspectos fundamentales para su detección oportuna y manejo adecuado.

  10. Quiste óseo aneurismático mandibular de tipo sólido Mandibular solid aneurysmal bone cyst

    Directory of Open Access Journals (Sweden)

    Marta Saldaña Rodríguez

    2013-06-01

    Full Text Available El quiste óseo aneurismático sólido es una lesión ósea benigna muy infrecuente de la que no existe consenso en relación a su origen etiopatogénico. Presenta características clínicas, radiológicas e histológicas inespecíficas, por lo que los estudios ultraestructurales son fundamentales para su diagnóstico y clasificación. El diagnóstico diferencial es extenso e incluye múltiples lesiones óseas como el granuloma reparativo de células gigantes e incluso tumores malignos como el osteosarcoma. El tratamiento de elección es la cirugía conservadora. La recidiva se debe fundamentalmente a la extirpación incompleta.Solid aneurysmal bone cyst is a rare benign bone lesion for which no consensus exists regarding its origin. It has nonspecific clinical, radiological and histological features so ultrastructural studies are essential for diagnosis and classification. The differential diagnosis is extensive and includes a variety of bone lesions, such as giant cell reparative granuloma, and even malignant tumors like osteosarcoma. The treatment of choice is conservative surgery. Recurrence is due mainly to incomplete resection.

  11. Quiste óseo aneurismático

    OpenAIRE

    Ferdinando de Conto; Manoela Moura de Bortoli; Jéssica Galvan; Gisele Rovani; Mateus Ericson Flores; Roque Miguel Rhoden

    2012-01-01

    El quiste óseo aneurismático (QOA) es una lesión benigna rara en huesos maxilares, su mayor frecuencia es en huesos largos del esqueleto y columna vertebral. Algunos autores especulan que el origen sea por trauma, mala formación o un neoplasma. El aspecto radiográfico puede mostrar desde una imagen difusa hasta una imagen bien definida, muy semejante a las otras lesiones de los maxilares volviendo el diagnóstico diferencial amplio. Con la destrucción del córtex óseo puede todavía formar una i...

  12. Manejo clínico del quiste periapical

    OpenAIRE

    Clara Vergara Hernández

    2013-01-01

    ResumenEl quiste periapical es una lesión inflamatoria de los maxilares formada en el periápice de dientes con pulpa necrótica e infectada siendo una secuela directa de un granuloma apical, están asociados a la raíz dentaria y se encuentran con mayor frecuencia en el maxilar superior. Por lo general no provocan síntomas y su lenta evolución hace que el paciente no se percate del mismo hasta que aparece la asimetría facial. Se presenta un caso correspondiente a un paciente masculino con lesión...

  13. Estudio de la fertilidad y viabilidad de quistes hidatídicos ovinos

    Directory of Open Access Journals (Sweden)

    García Llamazares José Luis

    1997-01-01

    Full Text Available FUNDAMENTO: La finalidad de este trabajo es analizar la fertilidad de los quistes hidatídicos de origen ovino, especie de gran interés epidemiológico en la hidatidosis, y la adecuación del gerbillo (Meriones unguiculatus como modelo experimental para el estudio "in vivo" de dicha hidatidosis, fase preliminar de posteriores estudios terapeúticos. MÉTODOS: Se ha realizado un estudio de la fertilidad y viabilidad de quistes hidatídicos procedentes de pulmones e hígados de ganado ovino de Castilla y León a través del examen y evaluación de una serie de parámetros entre los que figura la producción de una hidatidosis secundaria experimental en animales de laboratorio. RESULTADOS: El índice quístico total obtenido fue de 8,57 quistes por ovino infestado (5,97 quistes por pulmón infestado y 5,57 quistes por hígado infestado. El porcentaje de fertilidad obtenido en los quistes hidatídicos de origen ovino que contenían protoescólex viables "in vitro" fue del 43,97% (43,02% en los quistes pulmonares y 46,16% en los quistes hepáticos. La viabilidad "in vivo" de los protoescólex seleccionados se puso de manifiesto al producirse en el 100% de los gerbillos infectados una hidatidosis secundaria experimental. CONCLUSIONES: Se destaca la validez de los criterios utilizados para estudiar la viabilidad "in vitro" de los protoescólex procedentes de quistes hidatídicos de origen ovino. La hidatidosis secundaria producida en gerbillos nos conduce a considerarlos como especie de experimentación adecuada para la investigación "in vivo" de la hidatidosis de origen ovino.

  14. Quiste sinovial de articulación temporomandibular: presentación de un caso

    OpenAIRE

    José Ángel Tomás Amérigo; Luis Miguel Floría García; M. Carmen Baquero Ruiz de La Hermosa; Ernesto Bizcarrondo Ruiz; Francisco José Vera Sempere; José Delhom Valero

    2015-01-01

    El quiste sinovial localizado en la articulación temporomandibular es una entidad rara, con pocos casos reportados en la literatura médica. Gaisford et al. fueron los primeros autores que informaron de un caso de quiste sinovial, patología que afecta más frecuentemente a articulaciones como la muñeca o la rodilla. Estos quistes están delimitados por células sinoviales, y pueden estar comunicados o ser independientes de la cavidad articular. Se han propuesto varias teorías para explicar ...

  15. Quiste sinovial de articulación temporomandibular: presentación de un caso

    OpenAIRE

    José Ángel Tomás Amérigo; Luis Miguel Floría García; M. Carmen Baquero Ruiz de La Hermosa; Ernesto Bizcarrondo Ruiz; Francisco José Vera Sempere; José Delhom Valero

    2015-01-01

    El quiste sinovial localizado en la articulación temporomandibular es una entidad rara, con pocos casos reportados en la literatura médica. Gaisford et al. fueron los primeros autores que informaron de un caso de quiste sinovial, patología que afecta más frecuentemente a articulaciones como la muñeca o la rodilla. Estos quistes están delimitados por células sinoviales, y pueden estar comunicados o ser independientes de la cavidad articular. Se han propuesto varias teorías para explicar ...

  16. Opciones terapéuticas en quistes odontogénicos. Revisión

    OpenAIRE

    Vega Llauradó, A.; Ayuso Montero, Raúl; I. Teixidor Olmo; Jané Salas, Enric; Marí Roig, Antonio; López López, José

    2013-01-01

    Los huesos maxilares constituyen asiento de una gran variedad de quistes y neoplasias que pueden ser de difícil diagnóstico. De entre todos los procesos tumorales que se dan en el territorio maxilofacial, los quistes son de gran importancia debido a la frecuencia de su presentación. Los quistes maxilares tienen distinto origen y comportamiento clínico. A partir de la clasificación de la OMS de 1992, esta revisión estudia las características clínicas, radiográficas y epidemiológicas de los qui...

  17. Dwarfism and gigantism in historical picture postcards.

    Science.gov (United States)

    Enderle, A

    1998-05-01

    A collection of 893 historical picture postcards from 1900 to 1935, depicting dwarfs and giants, was analysed from medical and psychosocial viewpoints. In conditions such as 'bird headed dwarfism', achondroplasia, cretinism, so-called Aztecs or pinheads, Grebe chondrodysplasia, and acromegalic gigantism, the disorder could be diagnosed easily. In hypopituitary dwarfism, exact diagnosis was more difficult because of heterogeneity. The most common conditions depicted were pituitary dwarfism and achondroplasia. Most of those with gigantism had pituitary gigantism and acromegaly. Brothers and sisters or parents and their children provided evidence of mendelian inheritance of some of these disorders. The cards suggest that being put on show provided, at least in some cases, social benefits.

  18. Hidrocele gigante en paciente anciano

    OpenAIRE

    Ada Arleny Pérez Mayo; Yordania Velázquez Avila

    2014-01-01

    Se presenta el caso de un paciente de 87 años, intervenido por primera vez en el Hospital Nacional “San Pedro Necta” del Departamento de Huehuetenango en Guatemala, por presentar hidrocele gigante de más de veinte años de evolución. El examen físico mostró tumoración translúcida dolorosa en la bolsa escrotal izquierda, con el posible diagnóstico de hidrocele tabicado o no comunicante. El preoperatorio consistió en la canalización de vena periférica, administración de profilaxis antibiótica co...

  19. Pituitary Gigantism: A Case Report

    Directory of Open Access Journals (Sweden)

    Rana Bhattacharjee

    2012-01-01

    Full Text Available Objective: To present a rare case of gigantism. Case Report: A 25-year-old lady presented with increased statural growth and enlarged body parts noticed since the age of 14 years, primary amenorrhea, and frontal headache for the last 2 years.She has also been suffering from non-inflammatory low back pain with progressive kyphosis and pain in the knees, ankles, and elbows for the last 5 years. There was no history of visual disturbance, vomiting, galactorrhoea, cold intolerance. She had no siblings. Family history was non-contributory.Blood pressure was normal. Height 221 cm, weight 138 kg,body mass index (BMI28. There was coarsening of facial features along with frontal bossing and prognathism, large hands and feet, and small goitre. Patient had severe kyphosis and osteoarthritis of knees. Confrontation perimetry suggested bitemporal hemianopia. Breast and pubic hair were of Tanner stage 1. Serum insulin like growth factor-1 (IGF1 was 703 ng/ml with all glucose suppressedgrowth hormone (GHvalues of >40 ng/ml. Prolactin was 174 ng/ml. Basal serum Lutenising Hormone (LH, follicle stimulating Hormone (FSH was low. Oral glucose tolerance test (OGTT, liver and renal function tests, basal cortisol and thyroid profile, Calcium, phosphorus and Intact Parathyroid hormone (iPTH were normal.Computed tomographyscan of brain showed large pituitary macroadenoma. Automated perimetry confirmed bitemporal hemianopia. A diagnosis of gigantism due to GH secreting pituitary macroadenoma with hypogonadotrophichypogonadism was made. Debulking pituitary surgery followed by somatostatin analogue therapy with gonadal steroid replacement had been planned, but the patient refused further treatment.

  20. Quiste sinovial en el tendon del musculo tibial posterior. Caso clinico, consideraciones biomecanicas y revision bibliografica

    National Research Council Canada - National Science Library

    Valero Salas, Jose; Gallart Ortega, Jose; Gonzalez Lopez, David

    2014-01-01

    Se presenta un caso de quiste sinovial localizado en la cara interna del tobillo derecho de una paciente que presenta pies pronados de articulacion subastragalina con el antepie patologicamente compensado en supinacion...

  1. Gigantic Suprapubic Lymphedema: A Case Study

    National Research Council Canada - National Science Library

    Roozbeh Tanhaeivash; Tobias Franiel; Marc-Oliver Grimm; Marcus Horstmann

    2016-01-01

    We present the first case study of idiopathic gigantic suprapubic lymphedema and buried penis treated with puboscrotal reconstruction in a patient with initial extreme obesity after an extensive weight reduction (120 kg...

  2. Carcinoma en quiste tirogloso Carcinoma in thyroglosal duct cyst

    Directory of Open Access Journals (Sweden)

    M.E. Storani

    2010-09-01

    Full Text Available El carcinoma diferenciado de tiroides en quiste tirogloso (CaQT es una rara entidad. En diferentes series de pacientes operados por quistes tiroglosos su incidencia fue del 0.7 al 1.07%. Luego de la extirpación del quiste por el procedimiento de Sistrunk, no hay consenso sobre la indicación de tiroidectomía total, radioablación y/o terapéutica supresiva con levotiroxina. El objetivo del Departamento de tiroides de SAEM, fue evaluar: formas de presentación, evolución clínica, métodos diagnósticos de utilidad y tratamiento para consensuar futuras conductas. Material y Métodos: Estudio multicéntrico, retrospectivo en 22 pacientes entre 10 a 69 años, 15 mujeres y 7 varones. Resultados: El tamaño de los quistes osciló entre 1 y 8 cm (Mediana= 3.0 cm, Χ ± DS= 3.7 ± 2.2 cm. La mitad de los pacientes presentó crecimiento del quiste en los 6 meses previos a la cirugía. La punción resultó sospechosa en 2/5 quistes y positiva en uno. La ecografía tiroidea evidenció nódulos en 4/13 casos (30%. Se realizó tiroidectomía en 17/22 pacientes (total: 15 y subtotal: 2. La histología del CaQT demostró carcinoma papilar en 21 y carcinoma folicular en uno. Hubo coexistencia de cáncer intratiroideo en el 23.5% de los casos, ninguno multicéntrico. Dos pacientes presentaron metástasis ganglionares y otro tuvo compromiso muscular (ninguno de ellos coexistió con cáncer intratiroideo. Se radioablacionó a 13 pacientes. En 9/11 pacientes la tiroglobulina permaneció indetectable durante el seguimiento (1 a 14 años. Conclusiones: 1 Realizar ecografía de cuello y punción ecoguiada a todo paciente con quiste tirogloso. 2 En caso de CaQT combinar simultáneamente tiroidectomía total y procedimiento de Sistrunk. 3 Evaluar radioablación complementaria y tratamiento supresivo con levotiroxina en cada caso. 4 Efectuar el seguimiento tal como en los carcinomas ortotópicos.Differentiated thyroid carcinoma (DTC in thyroglosal duct cyst (TGDC is

  3. Dwarfism and gigantism in historical picture postcards.

    Science.gov (United States)

    Enderle, A

    1998-01-01

    A collection of 893 historical picture postcards from 1900 to 1935, depicting dwarfs and giants, was analysed from medical and psychosocial viewpoints. In conditions such as 'bird headed dwarfism', achondroplasia, cretinism, so-called Aztecs or pinheads, Grebe chondrodysplasia, and acromegalic gigantism, the disorder could be diagnosed easily. In hypopituitary dwarfism, exact diagnosis was more difficult because of heterogeneity. The most common conditions depicted were pituitary dwarfism and achondroplasia. Most of those with gigantism had pituitary gigantism and acromegaly. Brothers and sisters or parents and their children provided evidence of mendelian inheritance of some of these disorders. The cards suggest that being put on show provided, at least in some cases, social benefits. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 PMID:9764085

  4. Manejo clínico del quiste periapical

    Directory of Open Access Journals (Sweden)

    Clara Vergara Hernández

    2013-10-01

    Full Text Available ResumenEl quiste periapical es una lesión inflamatoria de los maxilares formada en el periápice de dientes con pulpa necrótica e infectada siendo una secuela directa de un granuloma apical, están asociados a la raíz dentaria y se encuentran con mayor frecuencia en el maxilar superior. Por lo general no provocan síntomas y su lenta evolución hace que el paciente no se percate del mismo hasta que aparece la asimetría facial. Se presenta un caso correspondiente a un paciente masculino con lesión de aspecto clínico tumoral en hemicara izquierda. Al examen radiográfico se observa imagen radiolúcida a nivel de incisivo central superior que continua con el ligamento periodontal. Se realiza biopsia por aspiración y basado en el estudio histopatológico, se diagnostica como quiste periapical. La conducta que se siguió con respecto al tratamiento fue quirúrgica. (DUAZARY 2010, 219 - 222AbstractThe periapical cyst it is an inflammatory injury of maxillaries formed in periápice of teeth with necrotic and infected pulp being a direct sequel of granuloma apical, is associate to the dental root and they are most frequently in superior maxilary. By the general they do not cause symptoms and its slow evolution causes that the patient does not notice of he himself until appears the face asymmetry. A case is exposed corresponding to a masculine patient with left injury of tumor like clinical aspect in hemicara. The radiographic examination radiolúcida image at level of superior central incisor is observed that continuous with the periodontal ligament. It makes biopsy by aspiration and based on the histopatológico study, it is diagnosed like periapical cyst. The conduct that was followed with respect to the treatment was surgical.Keywords: Periapical cyst; periapical disease; apical granuloma; periodontal ligament.

  5. Quiste esplénico abscedado: reporte de un caso

    Directory of Open Access Journals (Sweden)

    Roxana Montenegro

    2003-12-01

    Full Text Available Los autores reportan un raro caso de un absceso esplénico crónico, en un paciente varón de 52 años de edad; a quien dos años antes de su ingreso al hospital se le diagnosticó en forma casual -diagnóstico por imágenes- un quiste esplénico con paredes calcificadas, estando previamente asintomático. Al momento de su ingreso se presentó con una historia de 12 meses de dolor leve en cuadrante superior izquierdo del abdomen como única manifestación positiva. Luego de una intervención quirúrgica, el diagnóstico correspondió a un absceso esplénico crónico o seudoquiste esplénico por los hallazgos anatomopatológicos. Se describe las características del caso y se revisa la literatura.

  6. MANEJO LAPAROSCÓPICO DE QUISTES OVÁRICOS COMPLICADOS O PERSISTENTES DURANTE EL EMBARAZO

    OpenAIRE

    Troncoso J,José Luis; Ricci A,Paolo; Albornoz V,Jaime; Mackenna I,Antonio

    2009-01-01

    Antecedentes: El incremento en el hallazgo de quistes anexiales durante el embarazo sería el mayor uso de técnicas de reproducción asistida con hiperestimulación ovárica controlada. La complicación más frecuente sigue siendo la torsión anexial. Objetivo: Revisar el manejo de quistes anexiales complicados o persistentes, durante el embarazo, con resolución laparoscópica. Método: Revisión retrospectiva de 9 pacientes consecutivas, ingresadas al Departamento de Obstetricia y Ginecología Clínica ...

  7. Manejo bajo sedación consciente de quiste de erupción en infante

    OpenAIRE

    Alvarez-Páucar, Maria; Sacsaquispe-Contreras, Sonia; Paredes-Paredes, Ney

    2017-01-01

    El quiste de erupción es un quiste extra óseo justo antes de la erupción de los dientes, se presenta de color negro azulado, debido a su contenido sanguinolento. Los problemas clínicos causados por su presencia son: retraso de erupción y dolor durante la masticación. No precisa tratamiento si las lesiones desaparecen por sí solos al romperse espontáneamente, permitiendo la erupción dental, aunque no siempre sucede esto y en caso de dolor o infección. El objetivo del presente estudio fue repor...

  8. Quistes de los maxilares en el Servicio de Cirugía Maxilofacial de Artemisa

    OpenAIRE

    Juan Carlos Quintana Díaz; Mayriam Quintana Giralt

    2014-01-01

    Los quistes representan una de las principales causas de destrucción de los maxilares. La información relativa a estas entidades en la población cubana es escasa, por esto el propósito de la presente investigación es el presentar la frecuencia de los distintos tipos de quistes registrados en el servicio de cirugía máxilofacial en la ciudad de Artemisa, asícomo comparar los hallazgos con lo reportado en otros estudios y analizar su posible asociación con el sexo de los afectados y el tipo de d...

  9. Triangulation of the Gigantic Jets in 20 August 2014

    Science.gov (United States)

    Kang-Ming, P.; Hsu, R. R.; Su, H. T.; Chen, A. B. C.; Chou, J. K.; Chang, S. C.; Wu, Y. J.; Chien-Lun, H.; Yang, I. C.; Tsai, S. H.

    2015-12-01

    Coordinate optical observation campaigns on TLEs near Taiwan are held since 2011 with the aim to triangulate TLEs. Currently, there are four stations with baseline varying from 100 to 400 km between them. Our optical observation systems recorded 48 various types of TLEs on the night of 20 August 2014, with eight of them being gigantic jets that were recorded by at least two stations. Due to the length of baselines and the TLE occurring locations, the earth curvature needed to be taken into account by means of spherical trigonometry method. The preliminary results shows the gigantic jets occurred over the northern Taiwan and the accuracy of geolocation is less than 1 km and the accuracy of the retrieval height on the key structures is less than 0.5 km. The triangulation results of the eight events indicate most of these gigantic jets terminated at 80-90km, but one of the gigantic jets is likely extend to 100 km. Three of the eight gigantic jets occurred consequently after previous one with time interval of 500ms to more than 100s. The previous gigantic jet is likely to influence the consequent gigantic jet for usually the consequent gigantic jet has more beads structures in high altitude and one of the streamer column of a consequent gigantic jets at 55 -60 km is identified to re-bright, which is more than 100s after the previous gigantic jet.

  10. Quiste óseo aneurismático

    Directory of Open Access Journals (Sweden)

    Ferdinando de Conto

    2012-06-01

    Full Text Available El quiste óseo aneurismático (QOA es una lesión benigna rara en huesos maxilares, su mayor frecuencia es en huesos largos del esqueleto y columna vertebral. Algunos autores especulan que el origen sea por trauma, mala formación o un neoplasma. El aspecto radiográfico puede mostrar desde una imagen difusa hasta una imagen bien definida, muy semejante a las otras lesiones de los maxilares volviendo el diagnóstico diferencial amplio. Con la destrucción del córtex óseo puede todavía formar una imagen reaccional del periostio en forma de rayos de sol, característico de una lesión maligna. En este estudio, se presenta caso de paciente femenino, 17 años de edad, que buscó el Servicio de Cirugía y Traumatología Buco maxilofacial del Hospital São Vicente de Paulo-RS, que presentó dolor y aumento de volumen en la mandíbula. Informó que hace cerca de un año empezó a sentir malestar en la región junto al ángulo mandibular derecho, lo cual fue progresivamente aumentando de volumen. El aspecto radiográfico acordaba una lesión maligna. Después de la confirmación histopatológica de QOA, el tratamiento seleccionado para el caso fue quirúrgico conservador, con legrado de la cavidad ósea, y fue mantenido en control posoperatorio de rutina con 6 y 18 meses. En las radiografías panorámicas realizadas se verifica la neoformación ósea y cura del caso.

  11. MANEJO LAPAROSCOPICO CONSERVADOR DE QUISTE DERMOIDE CONTENIENDO UNA MANDIBULA Y 13 DIENTES

    OpenAIRE

    Zarhi T,Jaime; Toso L.,Juan M.

    2002-01-01

    Se presenta un caso clínico de quiste dermoide abordado en forma conservadora vía laparoscópica conteniendo maxilar superior y trece dientes, se discute su cuadro clínico, diagnóstico y tratamiento

  12. Quiste subaracnoideo y displasia del ala mayor del esfenoides en neurofibromatosis

    Directory of Open Access Journals (Sweden)

    J. Cortés-Arreguín

    Full Text Available Los quistes subaracnoideos representan menos del 1% de los tumores de ocupación intracraneal. Hay pocas publicaciones acerca de quistes subaracnoideos del lóbulo temporal con remodelación de la cavidad orbitaria, pero no existen en relación al tratamiento reconstructivo de la cavidad orbitaria en esta patología. Presentamos el caso clínico de un varón de 44 años de edad con diagnóstico de neurofibromatosis tipo 1, aumento progresivo de volumen del ojo y párpado izquierdos de 40 años de evolución y dolor retro-ocular intermitente desde hacía 10 años, al que se le diagnostica un quiste subaracnoideo del lóbulo temporal que invade la cavidad orbitaria con displasia del ala mayor del esfenoides. Realizamos drenaje y cistocisternostomía del quiste subaracnoideo, con reconstrucción de paredes orbitarias con malla de titanio y cobertura con un colgajo de pericráneo así como elevación y reposicionamiento del globo ocular mediante cantopexias, seguida de una osteotomía de la órbita para reducir el volumen de la misma.

  13. Evolution of gigantism in amphiumid salamanders.

    Science.gov (United States)

    Bonett, Ronald M; Chippindale, Paul T; Moler, Paul E; Van Devender, R Wayne; Wake, David B

    2009-05-20

    The Amphiumidae contains three species of elongate, permanently aquatic salamanders with four diminutive limbs that append one, two, or three toes. Two of the species, Amphiuma means and A. tridactylum, are among the largest salamanders in the world, reaching lengths of more than one meter, whereas the third species (A. pholeter), extinct amphiumids, and closely related salamander families are relatively small. Amphiuma means and A. tridactylum are widespread species and live in a wide range of lowland aquatic habitats on the Coastal Plain of the southeastern United States, whereas A. pholeter is restricted to very specialized organic muck habitats and is syntopic with A. means. Here we present analyses of sequences of mitochondrial and nuclear loci from across the distribution of the three taxa to assess lineage diversity, relationships, and relative timing of divergence in amphiumid salamanders. In addition we analyze the evolution of gigantism in the clade. Our analyses indicate three lineages that have diverged since the late Miocene, that correspond to the three currently recognized species, but the two gigantic species are not each other's closest relatives. Given that the most closely related salamander families and fossil amphiumids from the Upper Cretaceous and Paleocene are relatively small, our results suggest at least two extreme changes in body size within the Amphuimidae. Gigantic body size either evolved once as the ancestral condition of modern amphiumas, with a subsequent strong size reduction in A. pholeter, or gigantism independently evolved twice in the modern species, A. means and A. tridactylum. These patterns are concordant with differences in habitat breadth and range size among lineages, and have implications for reproductive isolation and diversification of amphiumid salamanders.

  14. Evolution of gigantism in amphiumid salamanders.

    Directory of Open Access Journals (Sweden)

    Ronald M Bonett

    Full Text Available The Amphiumidae contains three species of elongate, permanently aquatic salamanders with four diminutive limbs that append one, two, or three toes. Two of the species, Amphiuma means and A. tridactylum, are among the largest salamanders in the world, reaching lengths of more than one meter, whereas the third species (A. pholeter, extinct amphiumids, and closely related salamander families are relatively small. Amphiuma means and A. tridactylum are widespread species and live in a wide range of lowland aquatic habitats on the Coastal Plain of the southeastern United States, whereas A. pholeter is restricted to very specialized organic muck habitats and is syntopic with A. means. Here we present analyses of sequences of mitochondrial and nuclear loci from across the distribution of the three taxa to assess lineage diversity, relationships, and relative timing of divergence in amphiumid salamanders. In addition we analyze the evolution of gigantism in the clade. Our analyses indicate three lineages that have diverged since the late Miocene, that correspond to the three currently recognized species, but the two gigantic species are not each other's closest relatives. Given that the most closely related salamander families and fossil amphiumids from the Upper Cretaceous and Paleocene are relatively small, our results suggest at least two extreme changes in body size within the Amphuimidae. Gigantic body size either evolved once as the ancestral condition of modern amphiumas, with a subsequent strong size reduction in A. pholeter, or gigantism independently evolved twice in the modern species, A. means and A. tridactylum. These patterns are concordant with differences in habitat breadth and range size among lineages, and have implications for reproductive isolation and diversification of amphiumid salamanders.

  15. Gigantic Suprapubic Lymphedema: A Case Study

    Science.gov (United States)

    Tanhaeivash, Roozbeh; Franiel, Tobias; Grimm, Marc-Oliver

    2016-01-01

    We present the first case study of idiopathic gigantic suprapubic lymphedema and buried penis treated with puboscrotal reconstruction in a patient with initial extreme obesity after an extensive weight reduction (120 kg). Massive localized lymphedema of the suprapubic region should be differentiated from the scrotal type. Severe lymphedema could not resolve on its own and weight reduction does not seem to be helpful in such cases. PMID:27574599

  16. Giant basal cell carcinoma Carcinoma basocelular gigante

    Directory of Open Access Journals (Sweden)

    Nilton Nasser

    2012-06-01

    Full Text Available The basal cell carcinoma is the most common skin cancer but the giant vegetating basal cell carcinoma reaches less than 0.5 % of all basal cell carcinoma types. The Giant BCC, defined as a lesion with more than 5 cm at its largest diameter, is a rare form of BCC and commonly occurs on the trunk. This patient, male, 42 years old presents a Giant Basal Cell Carcinoma which reaches 180 cm2 on the right shoulder and was negligent in looking for treatment. Surgical treatment was performed and no signs of dissemination or local recurrence have been detected after follow up of five years.O carcinoma basocelular é o tipo mais comum de câncer de pele, mas o carcinoma basocelular gigante vegetante não atinge 0,5% de todos os tipos de carcinomas basocelulares. O Carcinoma Basocelular Gigante, definido como lesão maior que 5 cm no maior diâmetro, é uma forma rara de carcinoma basocelular e comumente ocorre no tronco. Este paciente apresenta um Carcinoma Basocelular Gigante com 180cm² no ombro direito e foi negligente em procurar tratamento. Foi realizado tratamento cirúrgico e nenhum sinal de disseminação ou recorrência local foi detectada após 5 anos.

  17. Gigantism and Its Implications for the History of Life.

    Science.gov (United States)

    Vermeij, Geerat J

    2016-01-01

    Gigantism-very large body size-is an ecologically important trait associated with competitive superiority. Although it has been studied in particular cases, the general conditions for the evolution and maintenance of gigantism remain obscure. I compiled sizes and dates for the largest species in 3 terrestrial and 7 marine trophic and habitat categories of animals from throughout the Phanerozoic. The largest species (global giants) in all categories are of post-Paleozoic age. Gigantism at this level appeared tens to hundreds of millions of years after mass extinctions and long after the origins of clades in which it evolved. Marine gigantism correlates with high planktic or seafloor productivity, but on land the correspondence between productivity and gigantism is weak at best. All global giants are aerobically active animals, not gentle giants with low metabolic demands. Oxygen concentration in the atmosphere correlates with gigantism in the Paleozoic but not thereafter, likely because of the elaboration of efficient gas-exchange systems in clades containing giants. Although temperature and habitat size are important in the evolution of very large size in some cases, the most important (and rare) enabling circumstance is a highly developed ecological infrastructure in which essential resources are abundant and effectively recycled and reused, permitting activity levels to increase and setting the stage for gigantic animals to evolve. Gigantism as a hallmark of competitive superiority appears to have lost its luster on land after the Mesozoic in favor of alternative means of achieving dominance, especially including social organization and coordinated food-gathering.

  18. Fungal cell gigantism during mammalian infection.

    Directory of Open Access Journals (Sweden)

    Oscar Zaragoza

    2010-06-01

    Full Text Available The interaction between fungal pathogens with the host frequently results in morphological changes, such as hyphae formation. The encapsulated pathogenic fungus Cryptococcus neoformans is not considered a dimorphic fungus, and is predominantly found in host tissues as round yeast cells. However, there is a specific morphological change associated with cryptococcal infection that involves an increase in capsule volume. We now report another morphological change whereby gigantic cells are formed in tissue. The paper reports the phenotypic characterization of giant cells isolated from infected mice and the cellular changes associated with giant cell formation. C. neoformans infection in mice resulted in the appearance of giant cells with cell bodies up to 30 microm in diameter and capsules resistant to stripping with gamma-radiation and organic solvents. The proportion of giant cells ranged from 10 to 80% of the total lung fungal burden, depending on infection time, individual mice, and correlated with the type of immune response. When placed on agar, giant cells budded to produce small daughter cells that traversed the capsule of the mother cell at the speed of 20-50 m/h. Giant cells with dimensions that approximated those in vivo were observed in vitro after prolonged culture in minimal media, and were the oldest in the culture, suggesting that giant cell formation is an aging-dependent phenomenon. Giant cells recovered from mice displayed polyploidy, suggesting a mechanism by which gigantism results from cell cycle progression without cell fission. Giant cell formation was dependent on cAMP, but not on Ras1. Real-time imaging showed that giant cells were engaged, but not engulfed by phagocytic cells. We describe a remarkable new strategy for C. neoformans to evade the immune response by enlarging cell size, and suggest that gigantism results from replication without fission, a phenomenon that may also occur with other fungal pathogens.

  19. Fungal cell gigantism during mammalian infection.

    Science.gov (United States)

    Zaragoza, Oscar; García-Rodas, Rocío; Nosanchuk, Joshua D; Cuenca-Estrella, Manuel; Rodríguez-Tudela, Juan Luis; Casadevall, Arturo

    2010-01-01

    The interaction between fungal pathogens with the host frequently results in morphological changes, such as hyphae formation. The encapsulated pathogenic fungus Cryptococcus neoformans is not considered a dimorphic fungus, and is predominantly found in host tissues as round yeast cells. However, there is a specific morphological change associated with cryptococcal infection that involves an increase in capsule volume. We now report another morphological change whereby gigantic cells are formed in tissue. The paper reports the phenotypic characterization of giant cells isolated from infected mice and the cellular changes associated with giant cell formation. C. neoformans infection in mice resulted in the appearance of giant cells with cell bodies up to 30 microm in diameter and capsules resistant to stripping with gamma-radiation and organic solvents. The proportion of giant cells ranged from 10 to 80% of the total lung fungal burden, depending on infection time, individual mice, and correlated with the type of immune response. When placed on agar, giant cells budded to produce small daughter cells that traversed the capsule of the mother cell at the speed of 20-50 m/h. Giant cells with dimensions that approximated those in vivo were observed in vitro after prolonged culture in minimal media, and were the oldest in the culture, suggesting that giant cell formation is an aging-dependent phenomenon. Giant cells recovered from mice displayed polyploidy, suggesting a mechanism by which gigantism results from cell cycle progression without cell fission. Giant cell formation was dependent on cAMP, but not on Ras1. Real-time imaging showed that giant cells were engaged, but not engulfed by phagocytic cells. We describe a remarkable new strategy for C. neoformans to evade the immune response by enlarging cell size, and suggest that gigantism results from replication without fission, a phenomenon that may also occur with other fungal pathogens.

  20. Sotos syndrome: An interesting disorder with gigantism

    Directory of Open Access Journals (Sweden)

    Nalini A

    2008-01-01

    Full Text Available We report the case of a 16-year-old boy diagnosed to have Sotos syndrome, with rare association of bilateral primary optic atrophy and epilepsy. He presented with accelerated linear growth, facial gestalt, distinctive facial features, seizures and progressive diminution of vision in both eyes. He had features of gigantism from early childhood. An MRI showed that brain and endocrine functions were normal. This case is of interest, as we have to be aware of this not so rare disorder. In addition to the classic features, there were two unusual associations with Sotos syndrome in the patient.

  1. Anemia hemolítica autoinmunitaria asociada a quiste benigno de ovario

    National Research Council Canada - National Science Library

    Millet, Antonio; Gomis, Cristina; Evangelio, Bienvenido

    2009-01-01

    ... convencional. El rápido diagnóstico y el tratamiento quirúrgico de un quiste dermoide ovárico asociado resolvieron rápidamente la anemia y evitaron someter a la paciente a procedimientos quirúrgicos innecesarios y potencialmente peligrosos. CASO CLÍNICO Mujer blanca, de 24 años de edad, nuligesta y sin antecedentes medicoquirúrgicos de interés, que acu...

  2. Síndrome abdominal agudo debido a quiste infectado del mesenterio

    Directory of Open Access Journals (Sweden)

    José Martín Palacios-Acosta

    2015-10-01

    Full Text Available Los quistes del mesenterio son lesiones benignas intrabdominales que crecen a expensas de los vasos linfáticos del intestino; son más frecuentes en el mesenterio ileal y muy raros en la edad pediátrica. El síndrome abdominal agudo en la edad pediátrica es difícil de definir al ser un cuadro de origen múltiple y de presentación clínica muy variada; su síntoma principal es el dolor abdominal agudo, una de las causas que con mayor frecuencia motivan consulta en el Servicio de Urgencias Pediátricas. Los quistes de mesenterio son infrecuentes, se estima que se presentan en uno de cada 100 000 ingresos por síndrome abdominal agudo en pediatría. El estudio de elección para el diagnóstico es el ultrasonido abdominal y el tratamiento óptimo es la resección completa del quiste. Se presenta el caso de una paciente con tumor abdominal ingresada para su estudio. Durante su evolución tuvo datos de irritación peritoneal por lo que se decidió realizar una laparotomía exploradora en la que se encontró un quiste del mesenterio, roto e infectado. Se efectuó hemicolectomía izquierda, lavado de cavidad y colostomía de una sola boca. A los tres meses de operada se hizo la restitución del tránsito intestinal con buenos resultados.

  3. Ondas T negativas gigantes de origen indeterminado

    Directory of Open Access Journals (Sweden)

    Eduardo Eyheremendy

    2009-01-01

    Full Text Available Se define onda T negativa gigante o inversión masiva de la onda T a la aparición de ondas T negativas con una amplitud = 1 mV en por lo menos dos derivaciones contiguas del ECG. Se presenta el caso de una paciente de 66 años con antecedentes de dislipidemia tipo IV e hipertensión arterial leve, a la que en buen estado de salud y totalmente asintomática en un examen de rutina se le detecta en el ECG de superficie un hemibloqueo anterior y ondas T negativas gigantes en las derivaciones I, II, aVL, aVF y de V1 a V6. La paciente fue internada en la UCI, donde se descartó que fueran de origen coronario. Durante el seguimiento, las ondas T se tornaron menos negativas hasta que al cabo de un tiempo (45 días aproximadamente se normalizaron. A pesar de los estudios cardiológicos y no cardiológicos realizados, no se pudo establecer su origen.REV ARGENT CARDIOL 2009;77:131-134.

  4. Pyodermia chronica glutealis complicated by acromegalic gigantism.

    Science.gov (United States)

    Nishijima, S; Kasahara, M; Suzuki, K; Kondoh, M; Tsubura, A

    1998-04-01

    We report a case of pyodermia chronica glutealis complicated by acromegalic gigantism associated with hyperprolactinemia. The serum prolactin, growth hormone, adrenocorticotropic hormone, and 11-deoxycortisol levels were elevated, but the estradiol and dehydroepiandrosterone-sulphate levels were within normal limits. However, the testosterone level was very low. Histopathologically, we found sinus tracts and scarring in a specimen from the buttocks. We could not immunohistochemically detect clear androgen, growth hormone, or prolactin receptors at any site. The patient was a man with a height of 197 cm and weight of 140 kg, he had clinical features of active acromegaly such as excessive sweating and increased thickness of soft tissue. He was also diagnosed with diabetes mellitus. Under such conditions, bacteria could easily grow and lesions might have been aggravated by the heavy pressure from his weight, a possible causes of his pyodermia chronica glutealis.

  5. Aneurisma gigante da arteria cerebral media: relato de um caso

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    Geraldo Pianetti Filho

    1978-06-01

    Full Text Available É relatado um caso de aneurisma gigante da artéria cerebral média com as dimensões de 12,0 x 8,0 x 6,0 cm, tratado cirurgicamente mediante craniotomia e ressecção. É feita breve análise da conduta diante dos aneurismas gigantes. Os autores acreditam ser este o maior aneurisma cerebral já descrito até o presente momento.

  6. Gigantism and Its Implications for the History of Life.

    Directory of Open Access Journals (Sweden)

    Geerat J Vermeij

    Full Text Available Gigantism-very large body size-is an ecologically important trait associated with competitive superiority. Although it has been studied in particular cases, the general conditions for the evolution and maintenance of gigantism remain obscure. I compiled sizes and dates for the largest species in 3 terrestrial and 7 marine trophic and habitat categories of animals from throughout the Phanerozoic. The largest species (global giants in all categories are of post-Paleozoic age. Gigantism at this level appeared tens to hundreds of millions of years after mass extinctions and long after the origins of clades in which it evolved. Marine gigantism correlates with high planktic or seafloor productivity, but on land the correspondence between productivity and gigantism is weak at best. All global giants are aerobically active animals, not gentle giants with low metabolic demands. Oxygen concentration in the atmosphere correlates with gigantism in the Paleozoic but not thereafter, likely because of the elaboration of efficient gas-exchange systems in clades containing giants. Although temperature and habitat size are important in the evolution of very large size in some cases, the most important (and rare enabling circumstance is a highly developed ecological infrastructure in which essential resources are abundant and effectively recycled and reused, permitting activity levels to increase and setting the stage for gigantic animals to evolve. Gigantism as a hallmark of competitive superiority appears to have lost its luster on land after the Mesozoic in favor of alternative means of achieving dominance, especially including social organization and coordinated food-gathering.

  7. Etiologies and clinical presentation of gigantism in Algeria.

    Science.gov (United States)

    Chentli, Farida; Azzoug, Said; Amani, Mohammed El Amine; Haddam, Ali El Mahdi; Chaouki, Dalal; Meskine, Djamila; Chaouki, Mohamed Lamine

    2012-01-01

    True gigantism is an exceptional and fascinating pediatric disease. Our aim in this study was to describe the different etiologies of a large group of children with gigantism and the natural history of their growth. In this multicenter study, we considered as giant children, adolescents and adults whose heights were ≥3 SD compared to their target stature or to our population average lengths. Isolated hypogonadism and Klinefelter syndrome were excluded from this series. All underwent clinical exam, and hormonal and neurological investigations. From 1980 to 2010, we observed 30 giants: 26 males (86.6%) and 4 females (mean age 19.8 ± 11 years). Among the 13 patients (40.3%) who consulted before the age of 16 years, 9 had acromegaly and 6 had mental retardation and body malformations. Based on growth hormone (GH) secretion evaluation, 2 groups were observed: pituitary gigantism (n = 16): GH = 150 ± 252 ng/ml (n ≤ 5), and other causes with normal GH (0.7 ± 0.6 ng/ml): 6 Sotos syndrome and 8 idiopathic cases. Only the first group had neurological, ophthalmological, metabolic and cardiovascular complications and received treatment. The result was not optimal as GH normalization was not observed. Reduction of tumor size and decreased GH plasma values were not observed. Gigantism predominates in males. The main cause is GH excess. The diagnosis was very late except for cerebral gigantism. Complications were observed in pituitary gigantism only. Copyright © 2012 S. Karger AG, Basel.

  8. Pancreatitis aguda como presentación de un quiste del conducto biliar en el adulto: reporte de caso

    OpenAIRE

    Enriquez Domínguez, Lenin; Díaz Rosales, Juna de Dios; Cabrera Hinojosa, Enrique; Gutiérrez Ramírez, Pedro; Aguayo Muñoz, Baltazar

    2010-01-01

    Paciente adulta se presentó en la sala de urgencias con un cuadro de pancreatitis aguda como complicación de un quiste del conducto biliar colédoco tipo IV, el cual fue diagnosticado por ultrasonograma abdominal durante su estancia intrahospitalaria. El diagnóstico de quiste de colédoco es más difícil en la edad adulta ya que los pacientes raramente se presentan con la triada clásica de dolor abdominal, masa palpable e ictericia, presentándose principalmente con alguna manifestación de ví...

  9. Quistes odontogénicos radiculares. Estudio clínico patológico de 62 casos.

    OpenAIRE

    Zaragozá Dolz, Vicente

    2007-01-01

    RESUMEN Este estudio fue realizado con 62 pacientes del Hospital General Universitario de Valencia, afectados de quiste radicular. Recogimos los siguientes datos: Edad, sexo, localización en los maxilares y la relación del quiste con el diente, tratamientos dentales previos, flemón, pulpitis, caries, traumatismo, movilidad dental, desplazamiento dental o radicular, rizolisis, progresión, dolor, tumefacción, supuración, fístula, pericoronaritis, fiebre, ulceración mucosa, trismus, densidad ...

  10. Tratamiento en sala de operaciones de dientes supernumerarios, inclusiones dentarias y quiste dentígero asociado

    OpenAIRE

    Aliaga Del Castillo, Rosalinda; Perea Paz, Miguel; De La Cruz Sedano, Gabriela Silvia; Aliaga Del Castillo, Arón

    2015-01-01

    Los dientes supernumerarios y las inclusiones de dientes permanentes son muy frecuentes en la infancia. Algunos dientes incluidos pueden estar asociados a la presencia de quistes dentígeros. Reportamos el caso de un paciente de sexo masculino de once años de edad con presencia de tresdientes supernumerarios en el maxilar superior, inclusión dentaria de pieza 11 e inclusión dentaria de pieza 13 con quiste dentígero asociado. El motivo de consulta fue precisamente la falta de las piezas 11 y 13...

  11. Fibroma ameloblástico versus quiste folicular hiperplásico Ameloblastic fibroma versus hyperplastic follicular cyst

    OpenAIRE

    Azúa-Romeo, J; E. Saura Fillat; T. Usón Bouthelier; M. Tovar Lázaro; J. Azúa Blanco

    2004-01-01

    Resumen: El fibroma ameloblástico (FA) es un tumor odontogénico mixto, compuesto por tejido mesenquimal y epitelio odontogénico, representando el 2% de los tumores odontogénicos, mientras que el quiste dentígero o folicular (QF), el segundo quiste odontogénico en frecuencia, está compuesto exclusivamente por tejido conjuntivo laxo (mesénquima), si bien, el saco fibroso puede contener restos de epitelio odontogénico incluidos, dando lugar a una imagen histológica muy similar. La importancia de...

  12. Quiste de colédoco. Presentación de un caso

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    Daniel Olivera Fajardo

    2012-06-01

    Full Text Available La dilatación congénita de las vías biliares y su incidencia es rara, se presenta un caso cada 100 000 a 150 000 nacimientos. La preocupación actual respecto a la evolución de este proceso, es que origine un colangiocarcinoma. Se presenta el caso de una adolescente de procedencia urbana, que acudió a  cuerpo de guardia de su área de salud, refiriendo que desde hacía aproximadamente 5 meses presentaba dolor  moderado en ¨la boca¨ del estómago y en la región superior derecha del abdomen que aparecía siempre después de ingerir alimentos, se aliviaba por sí solo y se acompañaba de vómitos. Su médico de familia  indicó ultrasonido abdominal, donde se observó un quiste en el hígado. Fue  trasladada al Cuerpo de Guardia del Hospital General Universitario Dr. Gustavo Aldereguía Lima, de Cienfuegos, donde fue valorada por el Servicio de Cirugía. Se decidió la realización de  tomografÍa axial computarizada de abdomen en la que se observó un quiste a nivel de la cabeza del páncreas. Se aplicó tratamiento quirúrgico. Los resultados anatomopatológicos mostraron colecistitis crónica, quiste de colédoco e inflamación crónica inespecífica.

  13. Quiste dermoide del suelo de la boca Dermoid cyst in the mouth floor

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    Ayelén María Portelles Massó

    2010-12-01

    Full Text Available El quiste dermoide representa menos del 0,01 % de todos los quistes de la cavidad bucal. Su ubicación más frecuente es en suelo de boca. Se presenta el caso de una paciente femenina de 19 años de edad que hacía aproximadamente 7 años había notado un aumento de volumen debajo de la lengua, el cual le crecía paulatinamente y ya se apreciaba por fuera de la cara. Además, le ocasionaba molestias al hablar y al masticar. Se realizaron estudios complementarios y bajo anestesia general nasotraqueal. Se procedió a su exéresis quirúrgica mediante un abordaje intrabucal, donde se obtuvieron excelentes resultados estéticos y funcionales. El diagnóstico histopatológico se correspondió con un quiste dermoide de suelo de boca. La paciente no ha tenido recurrencia de la lesión transcurridos tres años de la operación. El quiste dermoide de suelo de boca se presenta como una tumoración benigna de la línea media. La exéresis intrabucal demuestra beneficios estéticos y funcionales.The Dermoid cyst account for the 0.01 % of all cysts of buccal cavity. Its more frequent location is in the mouth floor. This is the case of a female patient aged 19 who approximately 7 years noted an increase of volume under tongue growing gradually and noting outside face and the discomfort at to speak and to chew. Complementary studies were conducted and under general anesthesia a surgical exeresis was carried out by intrabuccal approach achieving excellent esthetic and functional results. Histopathologic diagnosis matched with a dermoid cyst of mouth floor. Patient has not lesion recurrence after three years after operation. We conclude that the Dermoid cyst of mouth floor appear as benign tumor of middle line. The intrabuccal exeresis demonstrates esthetic and functional benefits.

  14. Quistes de los maxilares: Revisión bibliográfica Maxillary cysts: Bibliographical review

    OpenAIRE

    Luis O. Rodríguez García; Reina Guiardinu Martínez; Manuela Arte Loriga; Antonio O Blanco Ruiz

    2006-01-01

    Se realiza una revisión sobre el tema de los quistes de los maxilares con el objetivo de ampliar los conocimientos sobre este tema, debido a los trastornos que estos pueden ocasionar tanto estética como funcionalmente y la afectación que pueden producir en la integridad del componente maxilofacial, de ahí la importancia de un diagnóstico y tratamiento adecuados.A review of the maxillary cysts was made aimed at extending the knowledge on this topic, due to the disorders they may cause from the...

  15. Quistes de Tarlov sintomáticos: diagnóstico y tratamiento

    OpenAIRE

    López, V.J.; Godoy,R.; Marín, J.; M.C. Castro; Castillo, F

    2012-01-01

    Los quistes de Tarlov se forman a expensas de la duramadre y de la aracnoides alrededor de las raíces sacras o coccígeas. Habitualmente asintomáticos, en ocasiones pueden ocasionar clínica álgica de irritación radicular. El desarrollo de técnicas de imagen, principalmente la resonancia magnética nuclear (RMN), permiten diagnosticarlos con más frecuencia, aunque determinar si son responsables de los síntomas de los pacientes continúa siendo difícil. El tratamiento inicial es conser...

  16. La descompresión de los grandes quistes maxilares: una contribución a la terapéutica quirúrgica

    OpenAIRE

    1997-01-01

    En aquellos casos en los que la presencia de un quiste maxilar de grandes dimensiones compromete a dientes o estructuras anatómicas adyacentes importantes deben valorarse las consecuencias que puede conllevar su exéresis total en una única intervención quirúrgica. Este trabajo valora y discute los diferentes tratamientos que pueden ser realizados ante la presencia de un quiste maxilar dependiendo de sus características (localización, tamaño, tipo de quiste, origen, etc) y describe nuestra exp...

  17. Opciones terapéuticas en quistes odontogénicos: Revisión Therapeutic options in odontogenic cyst: Review

    OpenAIRE

    Vega Llauradó, A.; R. Ayuso Montero; I. Teixidor Olmo; J. Salas Enric; A. Marí Roig; J López López

    2013-01-01

    Los huesos maxilares constituyen asiento de una gran variedad de quistes y neoplasias que pueden ser de difícil diagnóstico. De entre todos los procesos tumorales que se dan en el territorio maxilofacial, los quistes son de gran importancia debido a la frecuencia de su presentación. Los quistes maxilares tienen distinto origen y comportamiento clínico. A partir de la clasificación de la OMS de 1992, esta revisión estudia las características clínicas, radiográficas y epidemiológicas de los qui...

  18. Adenoma paratiroideo ectópico mediastinal: Diagnóstico por sonda de detección gamma y resección por videotoracoscopia Ectopic mediastinal parathyroid adenoma: Detection with a radioisotopic probe and resolution with videothoracoscopy

    Directory of Open Access Journals (Sweden)

    Daniel Moncet

    2006-10-01

    Full Text Available Presentamos el caso de una mujer de 66 años con diagnóstico de hiperparatiroidismo primario por adenoma paratiroideo ectópico mediastinal realizado por gammagrafía paratiroidea con 99mtc-metoxi-isobutil-isonitrito (Tc99-MIBI. Fue intervenida exitosamente mediante la técnica de videotoracoscopia. Durante el procedimiento se utilizó la medición de parathormona y a los 10 minutos de extirpado el adenoma se obtuvo un descenso mayor del 50% del basal. La sonda de detección gamma no fue efectiva in situ por la superposición del radioisótopo con el miocardio pero confirmó la radioactividad dentro del quirófano una vez extirpado el adenoma. La paciente normalizó los valores de calcemia y parathormona en el postoperatorio y permaneció normocalcémica luego de 9 meses de seguimiento. En nuestro caso, la localización prequirúrgica y el monitoreo de parathormona intraoperatoria fueron de gran utilidad para el éxito quirúrgico, la sonda detectora marcada con Tc99-MIBI no fue efectiva in situ pero confirmó la radioactividad una vez extirpado el adenoma. El tratamiento quirúrgico endoscópico por videotoracoscopia fue bien tolerado, menos doloroso que la toracotomía y acortó el tiempo de internación.We report a 66 years old woman with a diagnosis of primary hyperparathyroidism. Localization to mediastinum was obtained with parathyroid scintigraphy using 99mtc-methoxy-isobutyl-isonitrite (Tc99-MIBI. The patient was successfully operated upon by means of a videothora-coscopic approach. During the procedure serum parathormone was measured before and 10 minutes after adenomectomy, showing a more than 50% reduction from the basal level. An attempt to detect the precise site of the adenoma with a Tc99-MIBI probe was unsuccessful because of its proximity to the myocardium, but radioactivity was confirmed on the surgical specimen after resection. The patient's calcemia and parathormone levels became normal during the postoperative course and she

  19. Identificación de células proliferativas en quistes de Taenia solium

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    Miguel Ángel Orrego-Solano

    Full Text Available Los neoblastos son células totipotentes, únicas responsables de la proliferación y maduración de tejidos en platelmintos de vida libre. Células similares se han aislado en platelmintos parásitos como Echinococcus. Taenia solium causa la teniasis humana (intestinal y la cisticercosis en humanos y cerdos. La infección del cerebro con larvas (quistes de T. solium resulta en neurocisticercosis, hiperendémica en el Perú; su tratamiento se asocia a síntomas neurológicos graves. La capacidad proliferativa y el desarrollo de los estadios de T. solium aún no se describen, y no se ha caracterizado los neoblastos de este parásito. Se buscó células proliferativas en quistes de T. solium colectados de un cerdo infectado, que fueron identificadas al replicarse e incorporar el nucleótido bromodesoxiuridina, detectado con un anticuerpo monoclonal. Una línea celular estable de neoblastos sería útil para estudios sistemáticos in vitro sobre eficacia de drogas y sobre la biología de T. solium.

  20. Identificación de células proliferativas en quistes de Taenia solium

    Directory of Open Access Journals (Sweden)

    Miguel Ángel Orrego-Solano

    2014-12-01

    Full Text Available Los neoblastos son células totipotentes, únicas responsables de la proliferación y maduración de tejidos en platelmintos de vida libre. Células similares se han aislado en platelmintos parásitos como Echinococcus. Taenia solium causa la teniasis humana (intestinal y la cisticercosis en humanos y cerdos. La infección del cerebro con larvas (quistes de T. solium resulta en neurocisticercosis, hiperendémica en el Perú; su tratamiento se asocia a síntomas neurológicos graves. La capacidad proliferativa y el desarrollo de los estadios de T. solium aún no se describen, y no se ha caracterizado los neoblastos de este parásito. Se buscó células proliferativas en quistes de T. solium colectados de un cerdo infectado, que fueron identificadas al replicarse e incorporar el nucleótido bromodesoxiuridina, detectado con un anticuerpo monoclonal. Una línea celular estable de neoblastos sería útil para estudios sistemáticos in vitro sobre eficacia de drogas y sobre la biología de T. solium.

  1. Late paleozoic fusulinoidean gigantism driven by atmospheric hyperoxia.

    Science.gov (United States)

    Payne, Jonathan L; Groves, John R; Jost, Adam B; Nguyen, Thienan; Moffitt, Sarah E; Hill, Tessa M; Skotheim, Jan M

    2012-09-01

    Atmospheric hyperoxia, with pO(2) in excess of 30%, has long been hypothesized to account for late Paleozoic (360-250 million years ago) gigantism in numerous higher taxa. However, this hypothesis has not been evaluated statistically because comprehensive size data have not been compiled previously at sufficient temporal resolution to permit quantitative analysis. In this study, we test the hyperoxia-gigantism hypothesis by examining the fossil record of fusulinoidean foraminifers, a dramatic example of protistan gigantism with some individuals exceeding 10 cm in length and exceeding their relatives by six orders of magnitude in biovolume. We assembled and examined comprehensive regional and global, species-level datasets containing 270 and 1823 species, respectively. A statistical model of size evolution forced by atmospheric pO(2) is conclusively favored over alternative models based on random walks or a constant tendency toward size increase. Moreover, the ratios of volume to surface area in the largest fusulinoideans are consistent in magnitude and trend with a mathematical model based on oxygen transport limitation. We further validate the hyperoxia-gigantism model through an examination of modern foraminiferal species living along a measured gradient in oxygen concentration. These findings provide the first quantitative confirmation of a direct connection between Paleozoic gigantism and atmospheric hyperoxia.

  2. [Cryohypophysectomy in acromegaly and gigantism by the stereotaxic method].

    Science.gov (United States)

    Mempel, E; Rap, Z; Jurkiewicz, J; Kuciński, L

    1985-01-01

    The authors report results of surgical treatment of 30 patients treated by cryohypophysectomy by the stereotactic method through the nose and sphenoid sinus in the years 1967-1979. The material included 28 cases of acromegaly and 2 cases of gigantism. The pathological manifestations in acromegaly and gigantism were analysed for demonstration which of them can regress after surgical treatment. The results of hormonal determinations, particularly the levels of growth hormone, 17-KS and hydroxysteroids, as well as blood glucose curves, were compared before and after cryohypophysectomy and their normalization was observed after the operation. There was principally no need for substitutive treatment after surgical treatment with the exception of 4 cases in which this treatment was given during several postoperative months. The indications to this method of therapy include cases of acromegaly and gigantism with presence of active intrasellar adenomas. Patients should be referred for treatment early before development of skeletal deformities.

  3. Ependimoma myxopapilar sacro gigante con osteolisis

    Science.gov (United States)

    Ajler, Pablo; Landriel, Federico; Goldschmidt, Ezequiel; Campero, Álvaro; Yampolsky, Claudio

    2014-01-01

    Objetivo: la presentación de un caso de una paciente con un ependimoma sacro con extensa infiltración y destrucción ósea local. Descripción del caso: una mujer de 53 años acudió a la consulta por dolor lumbosacro y alteraciones sensitivas perineales y esfinterianas. La imágenes por Resonancia Magnética (IRM) y la Tomografía Axial Computada (TAC) mostraron una lesión expansiva gigante a nivel S2-S4 con extensa osteólisis e invasión de tejidos adyacentes. Se realizó una exéresis tumoral completa con mejoría del estatus funcional. La anatomía patológica informó ependimoma mixopapilar. Discusión: la extensión de la resección quirúrgica es el mejor predictor de buen pronóstico. El tratamiento radiante se reserva como opción adyuvante para las resecciones incompletas y recidiva tumoral. La quimioterapia sólo debería utilizarse en casos en que la cirugía y la radioterapia estén contraindicadas. Conclusión: Los ependimomas mixopapilares sacros con destrucción ósea y presentación intra y extradural son muy infrecuentes y deben ser tenidos en cuenta entre los diagnósticos diferenciales preoperatorios. Su resección total, siempre que sea posible, es la mejor alternativa terapéutica. PMID:25165615

  4. Macrodystrophia Lipomatosa: An Unusual Cause of Localized Gigantism.

    Science.gov (United States)

    Maheswari, S Uma; Sampath, V; Ramesh, A; Manoharan, K

    2016-01-01

    Macrodystrophia lipomatosa (MDL) is a rare congenital form of localized gigantism characterized by progressive overgrowth of all mesenchymal elements with a disproportionate increase in fibro adipose tissue. Here we report a case of 20 years old male who presented with history of painless gradual enlargement of entire left upper limb since childhood. Magnetic resonance imaging and histopathology confirmed the diagnosis of macrodystrophia lipomatosa. This condition has to be differentiated from other causes of localized gigantism, since these conditions differ in their course, prognosis, complications and treatment.

  5. Macrodystrophia lipomatosa: An unusual cause of localized gigantism

    Directory of Open Access Journals (Sweden)

    S Uma Maheswari

    2016-01-01

    Full Text Available Macrodystrophia lipomatosa (MDL is a rare congenital form of localized gigantism characterized by progressive overgrowth of all mesenchymal elements with a disproportionate increase in fibro adipose tissue. Here we report a case of 20 years old male who presented with history of painless gradual enlargement of entire left upper limb since childhood. Magnetic resonance imaging and histopathology confirmed the diagnosis of macrodystrophia lipomatosa. This condition has to be differentiated from other causes of localized gigantism, since these conditions differ in their course, prognosis, complications and treatment.

  6. Quistes de los maxilares: Revisión bibliográfica Maxillary cysts: Bibliographical review

    Directory of Open Access Journals (Sweden)

    Luis O. Rodríguez García

    2006-12-01

    Full Text Available Se realiza una revisión sobre el tema de los quistes de los maxilares con el objetivo de ampliar los conocimientos sobre este tema, debido a los trastornos que estos pueden ocasionar tanto estética como funcionalmente y la afectación que pueden producir en la integridad del componente maxilofacial, de ahí la importancia de un diagnóstico y tratamiento adecuados.A review of the maxillary cysts was made aimed at extending the knowledge on this topic, due to the disorders they may cause from the aesthetic and functional point of view, and to the affection they may produce in the integrity of the maxillofacial component. That's why, an adequate diagnosis and treatment are important.

  7. Quiste branquial de localización anterior: Presentación de 1 caso

    Directory of Open Access Journals (Sweden)

    Alexis Cantero Ronquillo

    2002-04-01

    Full Text Available Se presenta un enfermo de 63 años de edad, con un tumor voluminoso en cara anterior del cuello, que se moviliza a la deglución. La biopsia aspirativa con aguja fina (BAAF informó tejido tiroideo. Se comprueba con la exéresis del tumor el diagnóstico de quiste branquial en una localización inusualA 63-year-old patient with a voluminous tumor in the anterior side of the neck that mobilizes on deglutition is presented. Thyroid tissue was found on performing fine needle aspiration biopsy (FNAB. The diagnosis of branchial cyst in an unsual localization was proved with the exeresis of the tumor

  8. First observations of Gigantic Jets from Monsoon Thunderstorms over India

    Science.gov (United States)

    Singh, Rajesh; Maurya, Ajeet; Chanrion, Olivier; Neubert, Torsten; Cummer, Steven; Mlynarczyk, Janusz; Bór, József; Siingh, Devendraa; Cohen, Morris; Kumar, Sushil

    2016-04-01

    Gigantic Jets are electric discharges from thunderstorm cloud tops to the bottom of the ionosphere at ~80 km altitude. After their first discovery in 2001, relatively few observations have been reported. Most of these are from satellites at large distances and a few tens from the ground at higher spatial resolution. Here we report the first Gigantic Jets observed in India from two thunderstorm systems that developed over the land surface from monsoon activity, each storm producing two Gigantic Jets. The jets were recorded by a video camera system at standard video rate (20 ms exposure) at a few hundred km distance. ELF measurements suggest that the jets are of the usual negative polarity and that they develop in less than 40 ms, which is faster than most jets reported in the past. The jets originate from the leading edge of a slowly drifting convective cloud complex close to the highest regions of the clouds and carry ~25 Coulomb of charge to the ionosphere. One jet has a markedly horizontal displacement that we suggest is caused by a combination of close-range cloud electric fields at inception, and longer-range cloud fields at larger distances during full development. The Gigantic Jets are amongst the few that have been observed over land.

  9. Surgery of gigantic infrarenal aneurysm of abdominal aorta

    Directory of Open Access Journals (Sweden)

    N. Rustempašić

    2005-08-01

    Full Text Available The case shows gigantic aneurysm of abdominal aorta, localized infrarenally, as well as aneurysms of bilateral iliac arteries, which were solved successfully by resection of aneurism of abdominal aorta, closure of iliac arteries near aortic bifurcation, and interposition of aorta-bifemural vascular graft. There were no postoperative complications,and final outcome was fully satisfactory.

  10. Gigantism in sibling unrelated to multiple endocrine neoplasia: case report.

    Science.gov (United States)

    Matsuno, A; Teramoto, A; Yamada, S; Kitanaka, S; Tanaka, T; Sanno, N; Osamura, R Y; Kirino, T

    1994-11-01

    The cases of gigantism sisters with somatotroph adenomas unrelated to multiple endocrine neoplasia (MEN) Type 1 are reported. The sisters grew rapidly since they were 5 or 6 years old and were diagnosed to have gigantism with pituitary adenoma by computed tomographic scan and magnetic resonance imaging. A serum endocrinological examination showed the elevated growth hormone values. After thyroxine-releasing hormone stimulation, growth hormone values exhibited a paradoxical rise. They were supposed to be unrelated to MEN Type 1, because analysis of the 11th chromosomes and the other endocrine functions were normal. They were operated on by the transphenoidal method. Immunohistochemical staining of both tumor specimens confirmed somatotroph adenomas. Pituitary adenoma associated with MEN Type 1 is a well-recognized entity. However, the sporadic occurrence of pituitary adenoma unrelated to MEN Type 1, especially in siblings, is extremely rare. Fifteen cases of pituitary adenomas in siblings were described in the literature. As for gigantism, only two brothers were reported. Our case of gigantism sisters is the second sporadic case. In our review of the isolated cases of pituitary adenoma in siblings described in the literature, 12 (70%) of 17 cases including ours are acromegaly or gigantism. This incidence is much higher than that of MEN Type 1 patients with pituitary adenomas. The cause of the familial occurrence of pituitary adenomas is still unclear, although autosomal recessive inheritance has been suggested. It has been stated that point mutations in codon 201 or 227 of the Gs alpha gene located in chromosome 20 were found in about 35 to 40% of somatotroph adenomas.(ABSTRACT TRUNCATED AT 250 WORDS)

  11. A gigantic feathered dinosaur from the lower cretaceous of China.

    Science.gov (United States)

    Xu, Xing; Wang, Kebai; Zhang, Ke; Ma, Qingyu; Xing, Lida; Sullivan, Corwin; Hu, Dongyu; Cheng, Shuqing; Wang, Shuo

    2012-04-04

    Numerous feathered dinosaur specimens have recently been recovered from the Middle-Upper Jurassic and Lower Cretaceous deposits of northeastern China, but most of them represent small animals. Here we report the discovery of a gigantic new basal tyrannosauroid, Yutyrannus huali gen. et sp. nov., based on three nearly complete skeletons representing two distinct ontogenetic stages from the Lower Cretaceous Yixian Formation of Liaoning Province, China. Y. huali shares some features, particularly of the cranium, with derived tyrannosauroids, but is similar to other basal tyrannosauroids in possessing a three-fingered manus and a typical theropod pes. Morphometric analysis suggests that Y. huali differed from tyrannosaurids in its growth strategy. Most significantly, Y. huali bears long filamentous feathers, thus providing direct evidence for the presence of extensively feathered gigantic dinosaurs and offering new insights into early feather evolution.

  12. Hamartoma mamario gigante: dos casos de una entidad rara

    Directory of Open Access Journals (Sweden)

    T.A. Gomes-Rodrigues

    2014-09-01

    Full Text Available El hamartoma gigante de la mama es una entidad clínico-patológica inusual que tiende a confundirse con otros tumores. A pesar del avance en las técnicas diagnósticas, su diagnóstico clínico es difícil y normalmente solo se confirma cuando se analiza toda la pieza de resección. El diagnóstico diferencial debe incluir entidades como el fibroadenoma, lipoma, tumor phyllodes y diversos tipos de carcinomas. Presentamos 2 casos de hamartoma gigante de mama en mujeres de edad media, de los cuales uno fue tratado mediante mastectomía conservadora de complejo pezónareola y reconstrucción con prótesis y el otro con biopsia escisional y remodelación con patrón de pexia mamaria.

  13. Nevo melanocítico congênito gigante

    Directory of Open Access Journals (Sweden)

    Guilherme Lippi Ciantelli

    2014-06-01

    Full Text Available Os nevos melanocíticos congênitos (NMC são lesões pigmentadas formadas a partir do acúmulo anormal de melanócitos neuroectodérmicos em uma localização ectópica e estão presentes em 1% dos recém-nascidos. Contudo, os NMC gigantes ocorrem em apenas 1:20.000 nascidos vivos, enquanto os com a típica distribuição em “calção de banho” são muito raros, estando presentes em apenas 1:500.000 nascidos vivos. Neste artigo os autores relatam um caso de NMC gigante em “calção de banho” devido a sua raridade, revisando os aspectos diagnósticos e terapêuticos desta afecção.

  14. Management of type 2 diabetes mellitus associated with pituitary gigantism.

    Science.gov (United States)

    Ali, Omar; Banerjee, Swati; Kelly, Daniel F; Lee, Phillip D K

    2007-01-01

    Pituitary gigantism, a condition of endogenous growth hormone (GH) hypersecretion prior to epiphyseal closure, is a rare condition. In the adult condition of GH excess, acromegaly, the occurrence of type 2 diabetes mellitus (T2DM) and diabetic ketoacidosis (DKA) have been reported, with resolution following normalization of GH levels. We report the case of a 16-year-old male with pituitary gigantism due to a large invasive suprasellar adenoma who presented with T2DM and DKA. Despite surgical de-bulking, radiotherapy and medical treatment with cabergoline and pegvisomant, GH and insulin-like growth factor-I (IGF-I) levels remained elevated. However, the T2DM and recurrent DKA were successfully managed with metformin and low-dose glargine insulin, respectively. We review the pathophysiology of T2DM and DKA in growth hormone excess and available treatment options.

  15. Quiste óseo simple atípico: Presentación de un caso clínico Atypical Simple Bone Cyst: A Case Report

    Directory of Open Access Journals (Sweden)

    L.R González

    2009-02-01

    Full Text Available El quiste óseo simple (sinonimia quiste óseo traumático, quiste óseo solitario, quiste óseo hemorrágico es un pseudoquiste intraóseo desprovisto de recubrimiento epitelial con un contenido seroso y/o hemático que en ocasiones puede estar ausente. Es una patología poco frecuente que afecta a los huesos maxilares con predilección por el maxilar inferior. El objetivo del presente trabajo es presentar un caso de quiste óseo simple en maxilar inferior que difiere de los habitualmente encontrados en los huesos maxilares en cuanto a su presentación clínica, radiográfica e histopatológica.The simple bone cyst (reported in the literature as traumatic bone cyst, solitary bone cyst, hemorrhagic bone cyst is an intraosseous pseudocyst devoid of epithelial lining and filled with serous and/or hematic fluid that may also be lacking. Is a an uncommon condition that usually affects the jaws, with predilection for the lower jaw. The aim of the present work was to report a case of traumatic bone cyst of the jaw that differs from other maxillary bone cysts in its clinical, radiologic, and histologic presentation.

  16. Teratoma gigante de mediastino anterior con taponamiento cardiaco.

    OpenAIRE

    Mario López-Carranza; Oswaldo Silva-Rodríguez; Américo Carbajal-Vásquez

    2012-01-01

    Los teratomas de mediastino, se adhieren y comprimen las estructuras adyacentes y rara vez producen taponamiento cardiaco; cuando ocurren se deben a la perforación del pericardio. Se presenta un paciente adulto, con teratoma mediastinal gigante, que presentó taponamiento cardiaco sin tener perforación pericárdica, siendo intervenido quirúrgicamente mediante incisión de Clamshell. Probablemente, constituya el teratoma mediastinal más grande con taponamiento cardiaco reportado.

  17. Iberulitos: part??culas atmosf??ricas ???gigantes??? potencialmente inhalables

    OpenAIRE

    P??rraga Mart??nez, Jes??s; Delgado Calvo-Flores, Gabriel; Mart??n Garc??a, Juan Manuel; Olmo Reyes, Francisco Jos??; Delgado Calvo-Flores, Rafael

    2013-01-01

    Objetivos: Estudiar en Granada (??rea metropolitana) las part??culas atmosf??ricas sedimentables con ??nfasis en los iberulitos (part??culas agregadas gigantes de g??nesis atmosf??rica potencialmente inhalables), durante el verano de 2010 en el que se produjeron 14 eventos de entrada de aire africano. M??todos: Las part??culas sedimentables fueron muestreadas en r??gimen de ???dry deposition???. Los iberulitos fueron aislados de las part??culas sedimentables, en el campo de un est...

  18. Breast gigantism induced by D-penicillamine: case report

    Energy Technology Data Exchange (ETDEWEB)

    Cha, Ji Hyeon; Kim, Hak Hee; Kim, Sun Mi; Seo, Myung Hee; Yoon, Hoi Soo [College of Medicine, Ulsan Univ., Seoul (Korea, Republic of)

    2004-03-01

    D-penicillamine, a chelating agent of copper, is the drug of choice for the treatment of Wilson's disease. Breast enlargement is a rare complication arising from its use, and we report a case of breast gigantism which developed after it had been used for ten months to treat this condition. Mammography demonstrated bilaterally enlarged dense breasts; ultrasonography, similarly, demonstrated enlargement, revealing the presence of a mass, shown at biopsy to be benign, in the left one.

  19. Multiple origins of gigantism in stem baleen whales

    Science.gov (United States)

    Tsai, Cheng-Hsiu; Kohno, Naoki

    2016-12-01

    Living baleen whales (Mysticeti) include the world's largest animals to have ever lived—blue whales ( Balaenoptera musculus) can reach more than 30 m. However, the gigantism in baleen whales remains little explored. Here, we compiled all published stem mysticetes from the Eocene and Oligocene and then mapped the estimated body size onto different phylogenies that suggest distinct evolutionary histories of baleen whales. By assembling all known stem baleen whales, we present three novel findings in early mysticete evolution. Results show that, regardless of different phylogenetic scenarios, large body size (more than 5-m long) evolved multiple times independently in their early evolutionary history. For example, the earliest known aetiocetid ( Fucaia buelli, 33-31 Ma) was small in size, about 2 m, and a later aetiocetid ( Morawanocetus-like animal, 26-23 Ma) can reach 8-m long—almost four times the size of Fucaia buelli—suggesting an independent gigantism in the aetiocetid lineage. In addition, our reconstruction of ancestral state demonstrates that the baleen whales originated from small body size (less than 5 m) rather than large body size as previously acknowledged. Moreover, reconstructing the evolution of body size in stem baleen whales suggests that the initial pulse of mysticete gigantism started at least back to the Paleogene and in turn should help to understand the origin, pattern, and process of the extreme gigantism in the crown baleen whales. This study illustrates that Cope's rule is insufficient to explain the evolution of body size in a group that comprises the largest animals in the history of life, although currently the lack of exact ancestor-descendant relationships remains to fully reveal the evolutionary history of body size.

  20. Teratoma gigante de mediastino anterior con taponamiento cardiaco

    Directory of Open Access Journals (Sweden)

    Mario López-Carranza

    2012-07-01

    Full Text Available Los teratomas de mediastino, se adhieren y comprimen las estructuras adyacentes y rara vez producen taponamiento cardiaco; cuando ocurren se deben a la perforación del pericardio. Se presenta un paciente adulto, con teratoma mediastinal gigante, que presentó taponamiento cardiaco sin tener perforación pericárdica, siendo intervenido quirúrgicamente mediante incisión de Clamshell. Probablemente, constituya el teratoma mediastinal más grande con taponamiento cardiaco reportado.

  1. Teratoma gigante de mediastino anterior con taponamiento cardiaco.

    OpenAIRE

    López-Carranza, Mario; Cirujano de tórax y cardiovascular. Servicio de Cirugía Torácica y Cardiovascular. Hospital Víctor Lazarte Echegaray EsSalud. Trujillo.; Silva-Rodríguez, Oswaldo; Anátomo-Patólogo. Servicio de Anatomía Patológica. Hospital Víctor Lazarte Echegaray EsSalud. Trujillo.; Carbajal-Vásquez, Américo; Médico Anátomo-Patólogo. Hospital Víctor Lazarte Echegaray EsSalud. Trujillo.

    2012-01-01

    Los teratomas de mediastino, se adhieren y comprimen las estructuras adyacentes y rara vez producen taponamientocardiaco; cuando ocurren se deben a la perforación del pericardio. Se presenta un paciente adulto, con teratomamediastinal gigante, que presentó taponamiento cardiaco sin tener perforación pericárdica, siendo intervenidoquirúrgicamente mediante incisión de Clamshell. Probablemente, constituya el teratoma mediastinal más grandecon taponamiento cardiaco reportado.

  2. Multiple origins of gigantism in stem baleen whales.

    Science.gov (United States)

    Tsai, Cheng-Hsiu; Kohno, Naoki

    2016-12-01

    Living baleen whales (Mysticeti) include the world's largest animals to have ever lived-blue whales (Balaenoptera musculus) can reach more than 30 m. However, the gigantism in baleen whales remains little explored. Here, we compiled all published stem mysticetes from the Eocene and Oligocene and then mapped the estimated body size onto different phylogenies that suggest distinct evolutionary histories of baleen whales. By assembling all known stem baleen whales, we present three novel findings in early mysticete evolution. Results show that, regardless of different phylogenetic scenarios, large body size (more than 5-m long) evolved multiple times independently in their early evolutionary history. For example, the earliest known aetiocetid (Fucaia buelli, 33-31 Ma) was small in size, about 2 m, and a later aetiocetid (Morawanocetus-like animal, 26-23 Ma) can reach 8-m long-almost four times the size of Fucaia buelli-suggesting an independent gigantism in the aetiocetid lineage. In addition, our reconstruction of ancestral state demonstrates that the baleen whales originated from small body size (less than 5 m) rather than large body size as previously acknowledged. Moreover, reconstructing the evolution of body size in stem baleen whales suggests that the initial pulse of mysticete gigantism started at least back to the Paleogene and in turn should help to understand the origin, pattern, and process of the extreme gigantism in the crown baleen whales. This study illustrates that Cope's rule is insufficient to explain the evolution of body size in a group that comprises the largest animals in the history of life, although currently the lack of exact ancestor-descendant relationships remains to fully reveal the evolutionary history of body size.

  3. Granuloma central de células gigantes

    Directory of Open Access Journals (Sweden)

    Ayelén María Portelles Massó

    2011-03-01

    Full Text Available El granuloma reparativo central de células gigantes es una lesión proliferativa no neoplásica de etiología desconocida. Se presenta un paciente masculino de 40 años de edad, portador de prótesis parcial superior. Fue remitido al Servicio de Cirugía Maxilofacial del Hospital "V. I. Lenin" por presentar aumento de volumen en reborde alveolar superior, de color rojo grisáceo y que provocaba expansión de corticales óseas. Una vez analizados los exámenes clínicos, radiográficos e histopatológicos se diagnosticó un granuloma reparativo central de células gigantes Se realizó exéresis quirúrgica de la lesión y extracción de dientes adyacentes con una evolución satisfactoria sin señales de recidivas luego de tres años del tratamiento. El granuloma reparativo central de células gigantes se presentó como respuesta a un trauma. La correcta interpretación de los datos clínicos, radiográficos e histopatológicos nos permitió llegar al correcto diagnóstico y plan de tratamiento.

  4. Diagnóstico del consumidor de calamar gigante en México y en Sonora

    Directory of Open Access Journals (Sweden)

    Ma. Consepción Luna Raya

    2006-01-01

    con gustos y preferencias del consumidor del calamar gigante, se utilizaron resultados de 1,799 encuestas aplicadas en 14 ciudades del país. Los resultados de las encuestas indican que el consumo del calamar gigante, en frecuencia y cantidad, es bajo; no obstante, se encontró una tendencia hacia el consumo del calamar gigante con valor agregado. En términos generales, existen oportunidades para fomentar el consumo del calamar gigante en los ámbitos nacional y regional.

  5. Hiperparatiroidismo primario por adenoma paratiroideo mediastinal

    Directory of Open Access Journals (Sweden)

    Jeffry Solís-Torres

    2015-06-01

    Full Text Available El hiperparatiroidismo primario cursa con un aumento de la secreción de hormona paratiroidea, generalmente debido a un adenoma, e hipercalcemia. Su presentación clásica se diagnostica con la determinación de calcio sérico y de hormona paratiroidea, asociada con estudios de imágenes. Su tratamiento es quirúrgico y tiene altas tasas de éxito. Se analiza el caso de una paciente hipertensa, de 63 años, con historia de pérdida de apetito y debilidad de un año y medio de evolución, por lo que se le realizaron exámenes de laboratorio que revelaron hipercalcemia y elevación de la hormona paratiroidea. Se le indicó entonces una gamagrafía con Tecnecio 99, que evidenció un nódulo de 18mm de diámetro, ubicado 2 centímetros caudal al lóbulo tiroideo derecho. Se le efectuó una exploración cervical sin encontrarse la lesión, por lo que requirió una esternotomía media superior, que permitió encontrar un adenoma en el mediastino superior, detrás de la vena braquiocefálica derecha, de manera que se procedió a su extracción. Los controles de calcio y de hormona paratiroidea a las 24 horas estaban entre los límites normales, y se egresó.

  6. Quiste odontógeno: Presentación de caso

    Directory of Open Access Journals (Sweden)

    Gladys Pérez López

    2003-12-01

    Full Text Available Se presenta un paciente de 18 años de edad, remitido al Servicio de Otorrinolaringología del Hospital Clinicoquirúrgico "Comandante Manuel Fajardo", con el cuadro clínico de sinusitis recurrente y opacidad homogénea de seno maxilar izquierdo . La radiografia convencional de senos perinasales es considerada un medio diagnóstico muy importante al nivel de la atención primaria de salud, aunque también se considera necesario el ortopantograma para el diagnóstico diferencial (dientes supernumerarios, quistes dentígenos, molares retenidos. La técnica de Caldwell-Luc mejora la visibilidad y accesibilidad de las lesions, contribuye al diagnóstico, al alivio del paciente y está exenta de complicaciones.A case of 18-years old male patient with recurrent maxillary sinusitis and radiographic study with opacity in left maxillay sinus was reported. He was admitted at the Otorhinolaringology Department of "Comandante Manuel Fajardo" university clinical and surgical hospital. Conventional radiographic examination of perinasal sinus is considered a very important tool in primary health care; but also orthopantogram is required to exclude diverse diagnosis (supernumerary teeth, dentigenous cyst, and embedded tooth. The Caldwell-Luc approach improves visibility of and accesibility to lesions, contributes to make diagnosis and relieves the patient's condition without further complications. The most relevant quotations found in research works about the topic were selected.

  7. Impacto de la dieta sobre la inducción de infección con quistes de Giardia lamblia en ratas Sprague-Dawley

    Directory of Open Access Journals (Sweden)

    Díaz-Cinco Martha Elvia

    2002-01-01

    Full Text Available Objetivo. Evaluar el efecto de la desnutrición en la inducción de la giardiosis con diferentes concentraciones de quistes de Giardia lamblia utilizando como modelo animal ratas Sprague-Dawley. Material y métodos. Es un estudio experimental efectuado entre 1995 y 1999, en el Centro de Investigación en Alimentación y Desarrollo, de la ciudad de Hermosillo, estado de Sonora, México, y cuya muestra estuvo integrada por dos grupos de 6 a 8 unidades experimentales, las cuales recibieron dos tipos de dieta y cinco tratamientos con diferente concentración de inóculo de quistes de Giardia lamblia. Durante la fase experimental se monitoreó la excreción de quistes, ganancia de peso, consumo de alimento, análisis del contenido intestinal y daños macro y microscópicos en mucosa intestinal. El tratamiento estadístico de los datos consistió en análisis de varianza, y de residuales cuando fue necesario. Resultados. En los animales alimentados con una dieta que cubre sus requerimientos nutricionales (DN se observó que es posible provocar la infección con 60 quistes, mientras que en los animales desnutridos (dieta DLN la concentración que se requiere es de únicamente seis quistes para establecer daños a nivel de mucosa intestinal. Conclusiones. La ganancia de peso monitoreada durante los 10 días de ensayo no resultó ser un buen indicador de la infección por Giardia lamblia. El porcentaje de infección depende de la concentración de quistes inoculados y del estado de nutrición de los animales evaluados.

  8. Tumores en colisión: quiste velloso eruptivo y nevus melanocítico congénito Collision tumors: eruptive villous cyst and congenital melanocytic nevus

    Directory of Open Access Journals (Sweden)

    N E Driban

    2009-06-01

    Full Text Available Presentamos dos casos de un tumor en colisión, de quistes vellosos con nevus melanocíticos congénitos, comentando en forma breve, aquellas características de asociación entre quistes y nevus melanocíticos, con diferentes patologías en coexistencia tumoral.We presented two cases of a collision tumor, of a villous cyst within a congenital melanocytic nevus. We made short comments about those characteristics of the association of cysts and melanocytic nevus with different pathologies with tumoral coexistence.

  9. Radiografía periapical como herramienta en el diagnóstico y tratamiento de quiste periapical

    OpenAIRE

    2015-01-01

    Introducción: El quiste periapical es una lesión inflamatoria común de los maxilares, que al alcanzar un tamaño significativo, causa deformidad del hueso afectado, retención o incluso el desplazamiento de dientes adyacentes. Se presentó caso de paciente que acudió a consulta odontológica, por presencia de sintomatología dolorosa durante el consumo de alimentos. Al examen clínico se observó encía adherida con presencia de inflamación y enrojecimiento a nivel de órgano dentario 14; radiográfica...

  10. Quiste ovárico fetal: diagnóstico prenatal y manejo quirúrgico postnatal exitoso

    OpenAIRE

    Cabellos M,Alejandra; Cavieres C,Isabel; ZARGES T,PABLO; Gajardo C,Mario; Vega D,Richard

    2012-01-01

    Los quistes ováricos son el tumor abdominal mas frecuente en las recién nacidas. Presentan complicadones agudas y a largo plazo. La más frecuente es la torsión anexial que presenta dificultades diagnósticas en la etapa neonatal. El diagnóstico prenatal es fundamental para el manejo oportuno de las pacientes. Existen diferentes alternativas terapéuticas donde la cirugía mínimamente invasiva y conservadora juega un importante rol. Presentamos el caso de una recién nacida macrosómica con diagnós...

  11. The Oldest Recorded Case of Acromegaly and Gigantism in Iran.

    Science.gov (United States)

    Najjari, Mohsen

    2015-10-01

    Here we commemorate the character and academic authority of Prof. Zabiholah Gorban (1903-2006), the founder of Shiraz medical school. No doubt, in the scope of history of contemporary medicine, he has been efficient and effective. With respect to this fact, his article on a rare case described in Acta anatomica published in Iran in 1966, entitled (Observations on a giant skeleton) is browsed and reviewed. A case named Siah Khan with combined acromegaly and gigantism that appears to have letters to say still after nearly half a century.

  12. Hereditary Gigantism-the biblical giant Goliath and his brothers.

    Science.gov (United States)

    Donnelly, Deirdre E; Morrison, Patrick J

    2014-05-01

    The biblical giant Goliath has an identifiable family tree suggestive of autosomal dominant inheritance. We suggest that he had a hereditary pituitary disorder possibly due to the AIP gene, causing early onset and familial acromegaly or gigantism. We comment on the evidence within the scriptures for his other relatives including a relative with six digits and speculate on possible causes of the six digits. Recognition of a hereditary pituitary disorder in the biblical Goliath and his family sheds additional information on his and other family members' battles with David and his relatives.

  13. Proteus syndrome: A rare cause of gigantic limb

    Directory of Open Access Journals (Sweden)

    Nandini Chakrabarti

    2014-01-01

    Full Text Available A congenital disorder with variable manifestations, including partial gigantism of the hands and feet with hypertrophy of soles, nevi, hemihypertrophy, gynecomastia, macrocephaly and other skull abnormalities, and abdominal lipomatosis. The cause is unknown, although a genetic origin, generally of autosomal-dominant transmission, has been conjectured. Symptoms can be treated, but there is no known cure. We present the case of a young male with grotesque overgrowth of the right lower limb, splenomegaly and multiple nevi. Angiography revealed venous malformation within the limb. The findings are in conformity to the criteria for the Proteus syndrome.

  14. Osteoma gigante en mandíbula. Reporte de Caso.

    OpenAIRE

    Licéaga-Escalera, Carlos; Hospital Juárez de México. México D. F.; Del Bosque-Méndez, Jorge; Hospital Juárez de México. México D. F.; Aldape-Barrios, Beatriz; Facultad de Odontología, Universidad Nacional Autónoma de México. México D. F.; Montoya-Pérez, Luis; Hospital Juárez de México. México D. F., México; Morelos-Patiño, Ethien; Facultad de Odontología, Universidad Nacional Autónoma de México. México D. F.; González-Olmedo, Víctor; Facultad de Odontología, Universidad Nacional Autónoma de México. México D. F.

    2014-01-01

    El osteoma es una neoplasia benigna poco común, que se caracteriza por presentar un crecimiento óseo progresivo, el cual está compuesto por la proliferación bien diferenciada de hueso compacto y/o esponjoso. En el área maxilofacial se presenta con mayor frecuencia en la cara lingual posterior de la mandíbula. Se caracteriza por crecimiento lento y asintomático. El caso describe una paciente de 45 años con un osteoma gigante mandibular de 4 años de evolución tratado quirúrgicamente.

  15. Quiste cervical como manifestación inicial de un microcarcinoma papilar de tiroides

    Directory of Open Access Journals (Sweden)

    Jorge Fallas González

    2012-03-01

    Full Text Available Las masas quísticas en cuello son usualmente benignas en pacientes jóvenes. Sin embargo, tumores malignos de la cabeza y el cuello pueden presentarse ocasionalmente con metástasis quísticas. Se presenta el caso de una paciente de 33 años asintomática con una masa cervical quística de gran tamaño con 1 año de evolución, que inicialmente fue manejada como un quiste branquial, en quien luego de estudios por imagen e histopatológicos se sospechó carcinoma papilar de tiroides. Este diagnóstico fue corroborado en el trans-operatorio y se trató con tiroidectomía total, disección ganglionar del compartimiento central y disección ganglionar radical modificada derecha. El diagnóstico definitivo en el espécimen quirúrgico fue de un microcarcinoma papilar de tiroides con metástasis ganglionares quísticas y posteriormente la paciente recibió terapia con yodo radioactivoCystic cervical masses are usually benign in the young adult population. However malignant tumors of the head and neck may present ocasionally as cystic metastasis. Herein we report a case of a 33 year old female patient, asymptomatic, with a huge cystic cervical mass of 1 year data. The initial diagnosis was a branchial clef cyst, but after imaging studies and histopathologic examination papillary thyroid carcinoma was suspected. This diagnosis was confirmed in an intraoperatory consultation, so a total thyroidectomy, central lymph node dissection and modified radical neck dissection was performed. The final diagnosis on the surgical specimen was a papillary microcarcinoma of the thyroid with cystic lymph node metastasis and the patient received radioactive iodine afterwards

  16. Fractura patológica de la mandíbula asociada a quiste radicular: Reporte de 3 casos clínicos Mandibular pathologic fracture associated with radicular cyst: Report of three clinical cases

    OpenAIRE

    Bouguila, J.; L. Córdova Jara; I. Zairi; A. Adouani

    2008-01-01

    Introducción. El quiste radicular es el quiste más común de los maxilares. Su tamaño puede variar desde una lesión que abarca el proceso alveolar hasta uno extenso que oblitera el espacio antral maxilar o causa una fractura patológica mandibular. Reporte de casos. Se reportan tres casos con fractura patológica mandibular asociados a quiste radicular ocurridos después de trauma facial. El diagnóstico fue sugerido por un estudio clínico, radiografía panorámica y confirmado por el estudio histop...

  17. Quiste globulomaxilar de localización inusual: Reporte de un caso An unusual case of globulomaxillary cyst: a case report

    Directory of Open Access Journals (Sweden)

    J. Orozco Ariza

    2009-12-01

    Full Text Available El quiste globulomaxilar es un quiste no odontogénico localizado entre el incisivo lateral y canino del maxilar superior, radiográficamente aparece como una lesión radiolúcida unilocular que desplaza las mencionadas piezas dentarias mostrando una imagen de pera invertida característico de la lesión cuya lámina dura es continua y raras veces interrumpida. La valoración clínica radiográfica es importante para plantear en el diagnóstico diferencial la probable presencia del quiste globulomaxilar. La muestra anatomopatológica debe ser remitida íntegramente para su estudio y diagnóstico definitivo demostrando la presencia de tejido epitelial. Se presenta caso clínico de quiste globulomaxilar en un paciente femenino de 19 años de edad localizado entre canino y primer premolar superior izquierdo.Globulomaxillary cyst is a nonodontogenic cyst usually located between maxillary lateral incisor and canine. Radiographic images appears like an unilocular radiolucent lesion that displaced dental teeth showing a invert pear image characteristic of the lesion. X ray and clinical examinations are important to establish the differential diagnosis of globulomaxillary cyst. The hystological examination must be send to its study and definitive diagnoses showing the presence of epithelial tissue. A clinical case of globulomaxillary cyst is presented in a 19 -year- old female patient located between canine and left first premolar maxillary region.

  18. Impacto de la dieta sobre la inducción de infección con quistes de Giardia lamblia en ratas Sprague-Dawley

    National Research Council Canada - National Science Library

    Díaz-Cinco Martha Elvia; Ballesteros-Vázquez Martha Nydia; Pérez-Morales Rosalba; Mata-Haro Verónica

    2002-01-01

    Objetivo. Evaluar el efecto de la desnutrición en la inducción de la giardiosis con diferentes concentraciones de quistes de Giardia lamblia utilizando como modelo animal ratas Sprague-Dawley. Material y métodos...

  19. Tratamiento de quistes óseos aneurismáticos con aloinjerto. [Treatment of aneurysmal bone cysts with allograft].

    Directory of Open Access Journals (Sweden)

    Dany Olivera Nùñez

    2016-05-01

    Full Text Available Antecedentes Los pacientes con quiste óseo aneurismático (QOA plantean dificultades diagnósticas y terapéuticas. Han sido descritas múltiples opciones terapéuticas. Objetivos Nuestro objetivo fue evaluar los resultados obtenidos en pacientes tratados con curetaje y relleno con aloinjerto óseo. Material y métodos  Fue analizado un total de 16 quistes, correspondientes a 15 pacientes, con un seguimiento mínimo de 28 meses y una mediana de seguimiento de 83 meses. Resultados La edad media de los niños fue de 10 años (rango: 3-16 . La principal complicación fue la recidiva en el 37,5% de los pacientes, siendo más frecuente cuando existió compromiso fisario (62,5%  vs. 12,5% sin compromiso; p=0,05. La frecuencia de recidiva no varió para ambos sexos, para las distintas edades analizadas y respecto al uso o no de fresa de alta velocidad. Conclusión Pensamos que el tratamiento realizado es seguro, pero tiene una alta tasa de recidivas, similar a las publicadas en otras series.

  20. Transsphenoidal microsurgery in the treatment of acromegaly and gigantism.

    Science.gov (United States)

    Arafah, B U; Brodkey, J S; Kaufman, B; Velasco, M; Manni, A; Pearson, O H

    1980-03-01

    Twenty-five patients with acromegaly and 3 patients with gigantism underwent transsphenoidal microsurgery in an attempt to remove the tumor and preserve normal pituitary function whenever possible. An adenoma was identified and removed in 27 of 28 patients. Evaluation 3--6 months postoperatively revealed a GH level less than 5 ng/ml in 29 patients, 5--10 ng/ml in 4 patients and 11--29 ng/ml in 4 other patients. Dynamics of GH secretion were normal in 11 patients who had normal pituitary function and are considered cured. Two patients with low or undetectable GH levels are also considered cured at the expense of being hypopituitary. Three of 7 patients with normal basal GH levels but abnormal dynamics of GH secretion relapsed within 1 yr. Eleven of the 13 patients considered cured did not have extrasellar extension, while 14 of the 15 patients not cured had extrasellar extension. Five patients who were not cured with surgery received radiation therapy. Three patients were treated with an ergot derivative, Lergotrile mesylate, after surgery and radiation therapy failed to normalize GH levels. Transsphenoidal microsurgery is an optimal form of therapy for patients with acromegaly or gigantism, especially those with no extrasellar extension. Dynamics of GH secretion are very useful in evaluating the completeness of adenoma removal.

  1. Tumores y quistes del hígado: tratamiento quirúrgico resectivo

    Directory of Open Access Journals (Sweden)

    María Cristina Infante Carbonell

    1996-12-01

    Full Text Available Se aplicó tratamiento quirúrgico resectivo del hígado a 68 pacientes en los 3 hospitales clinicoquirúrgicos de Santiago de Cuba, durante 8 años (1987-1994. En 28 enfermos los tumores eran malignos, en 27 benignos y en el resto quistes solitarios, con predominio del hígado metastásico en los primeros y del hemangioma cavernoso en los segundos. El cáncer primitivo se diagnosticó en las etapas III y IV. Se practicaron 18 resecciones mayores, entre ellas 8 trisegmentectomías derechas, mientras que las restantes consistieron en resecciones menores y atípicas, sobre todo hepáticas regladas. Aparentemente las complicaciones peroperatorias y posoperatorias no tenían relación con la magnitud de la ablación. El absceso subfrénico fue el de mayor incidencia. La mortalidad no se relacionó con la técnica quirúrgica empleada, pero sí con la etapa clínica del tumor maligno y las complicaciones durante la operación y después de éstaLiver surgical resection treatment was applied to 68 patients in 3 clinical and surgical hospitals in Santiago de Cuba during 8 years (1987-1994. Tumours were malignant in 28 patients, benign in 27 and solitary cysts in the rest, with predominance of metastasic liver among the first and of cavernous hemangioma among the second ones. Primitive cancer was diagnosed in stages III and IV. 18 major resections were performed. 8 of them were right trisegmentectomies and the rest were minor and atypic resections, mainly ruled hepatic resections. Apparently, preoperative and postoperative complications were not connected with the magnitude of ablation. The subphrenic abscess had the highest incidence. Mortality was not related to the surgical technique used, but it was to the clinical stage of the malignant tumour and to the complications during and after the operation

  2. Model of UV flashes due to gigantic blue jets

    Energy Technology Data Exchange (ETDEWEB)

    Milikh, G M [University of Maryland, College Park, MD, 20742 (United States); Shneider, M N [Princeton University, Princeton, NJ (United States)], E-mail: milikh@astro.umd.edu, E-mail: shneyder@princeton.edu

    2008-12-07

    Analysis of UV flashes observed by the UV detector on board the 'Tatiana' microsatellite suggests, based on their location, pulse width and energy of the source of the photons, that the flashes were generated by gigantic blue jets (GBJs). Presented in this paper is a numerical model of UV flashes due to a bunch of long streamers which form a leader, a prong such as that observed in a GBJ. Using a previously developed model of upward propagation of a long streamer in the exponential atmosphere the paper describes temporal evolution of the UV flux generated by a bunch of long streamers, in the given spectral range 300-400 nm used by the UV detector on board 'Tatiana'. The model is in agreement with the observations.0.

  3. A rare gigantic solitary cysticercosis pseudotumour of the neck

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    Seif J Uledi

    2010-11-01

    Full Text Available Cysticercosis is one of the ancient parasitic infections and endemic in many parts of the developing world. Humans acquire cysticercosis when they ingest pork tapeworm eggs either through faecal-oral route by eating faecally contaminated food or by auto infection.The clinical picture largely depends on the location of larval encystment. Neurocysticercosis is the most common form of presentation. Solitary extra neural lesions are quite rare and fairly small in size.We present a very unique case of 56 year old Malawian female with a very rare, long standing gigantic solitary cysticercosis pseudo tumour of the neck. By far, there is no documented report on incorrigible cysticercosis lesion with such a sheer size.Solitary extraneural cysticercosis lesions may mimic other soft tissue masses; therefore it is important for clinicians working in endemic regions to consider cysticercosis as a differential diagnosis when evaluating patients with soft tissue lesions.

  4. Avian-style respiration allowed gigantism in pterosaurs.

    Science.gov (United States)

    Ruxton, Graeme

    2014-08-01

    Powered flight has evolved three times in the vertebrates: in the birds, the bats and the extinct pterosaurs. The largest bats ever known are at least an order of magnitude smaller than the largest members of the other two groups. Recently, it was argued that different scaling of wingbeat frequencies to body mass in birds and bats can help explain why the largest birds are larger than the largest bats. Here, I extend this argument in two ways. Firstly, I suggest that different respiratory physiologies are key to understanding the restriction on bat maximum size compared with birds. Secondly, I argue that a respiratory physiology similar to birds would have been a prerequisite for the gigantism seen in pterosaurs.

  5. Osteocondroma gigante de falange en paciente pediátrico

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    C.M. Noval-Font

    Full Text Available El osteocondroma es uno de los tumores óseos más frecuentes, representando el 40 % de los tumores de hueso. En la mano supone el 20 % de los tumores óseos, a pesar de que sólo el 1 % de los osteocondromas se ubica a este nivel. Existen dos teorías respecto a su origen: una que indica que se debe a un defecto del crecimiento fisario y otra que defiende su naturaleza tumoral. Algunos autores recomiendan no tratarlo; sin embargo, se debe extirpar cuando produce sintomatología. Presentamos un caso clínico de osteocondroma gigante en la segunda falange del segundo dedo de la mano derecha de una paciente de 2 años de edad, con deformidad severa y alteraciones funcionales. Realizamos escisión mediante escoplo y curetaje medular con cucharilla y reconstrucción con material osteoconductor, con resultado satisfactorio.

  6. Granuloma central de células gigantes

    OpenAIRE

    Cava-Vergiú, Carlos-Enrique; Flores Cueto, Walter; Cáceres La Torre, Andreé

    2006-01-01

    Este artículo presenta el caso de una paciente que acudió a la Clínica Especializada en Odontología de la Universidad de San Martín de Porres. La paciente requería la exodoncia de las terceras molares inferiores. Mediante el examen radiológico se observó una imagen radiolúcida con bordes definidos a nivel apical de las piezas 4.7 y 4.8. El diagnóstico presuntivo planteado fue granuloma central de células gigantes. La presentación de esta lesión es muy rara y puede ser de crecimiento ...

  7. Gigantism caused by growth hormone secreting pituitary adenoma.

    Science.gov (United States)

    Rhee, Noorisaem; Jeong, Kumi; Yang, Eun Mi; Kim, Chan Jong

    2014-06-01

    Gigantism indicates excessive secretion of growth hormones (GH) during childhood when open epiphyseal growth plates allow for excessive linear growth. Case one involved a 14.7-year-old boy presented with extreme tall stature. His random serum GH level was 38.4 ng/mL, and failure of GH suppression was noted during an oral glucose tolerance test (OGTT; nadir serum GH, 22.7 ng/mL). Magnetic resonance imaging (MRI) of the brain revealed a 12-mm-sized pituitary adenoma. Transsphenoidal surgery was performed and a pituitary adenoma displaying positive immunohistochemical staining for GH was reported. Pituitary MRI scan was performed 4 months after surgery and showed recurrence/residual tumor. Medical treatment with a long-acting somatostatin analogue for six months was unsuccessful. As a result, secondary surgery was performed. Three months after reoperation, the GH level was 0.2 ng/mL and insulin-like growth factor 1 was 205 ng/mL. Case two involved a 14.9-year-old boy, who was referred to our department for his tall stature. His basal GH level was 9.3 ng/mL, and failure of GH suppression was reported during OGTT (nadir GH, 9.0 ng/mL). Pituitary MRI showed a 6-mm-sized pituitary adenoma. Surgery was done and histopathological examination demonstrated a pituitary adenoma with positive staining for GH. Three months after surgery, the GH level was 0.2 ng/mL and nadir GH during OGTT was less than 0.1 ng/mL. Pituitary MRI scans showed no residual tumor. We present two cases of gigantism caused by a GH-secreting pituitary adenoma with clinical and microscopic findings.

  8. Quiste dentígero asociado con mesiodens: Exposición de un caso, revisión de la literatura y diagnóstico diferencial Dentigerous cyst associated with mesiodens: a case report, literature review and differential diagnostic

    OpenAIRE

    F.J. Rodríguez Romero; S. Cerviño Ferradanes; P. Muriel Cueto

    2011-01-01

    El quiste dentígero es uno de los quistes odontogénicos más frecuentes y están asociados con la corona de un diente no erupcionado o en desarrollo. Cuando se asocian con dientes supernumerarios son poco frecuentes y constituyen el 5-6% de todos los quistes dentígeros. En región maxilar, el 90% de los casos se asocian a mesiodens. El objetivo de este artículo es exponer el caso de una adolescente de 14 años con un quiste dentígero asociado con un diente supernumerario (mesiodens) impactado en ...

  9. Quiste dentígero asociado con mesiodens: Exposición de un caso, revisión de la literatura y diagnóstico diferencial Dentigerous cyst associated with mesiodens: a case report, literature review and differential diagnostic

    OpenAIRE

    F.J. Rodríguez Romero; S. Cerviño Ferradanes; P. Muriel Cueto

    2011-01-01

    El quiste dentígero es uno de los quistes odontogénicos más frecuentes y están asociados con la corona de un diente no erupcionado o en desarrollo. Cuando se asocian con dientes supernumerarios son poco frecuentes y constituyen el 5-6% de todos los quistes dentígeros. En región maxilar, el 90% de los casos se asocian a mesiodens. El objetivo de este artículo es exponer el caso de una adolescente de 14 años con un quiste dentígero asociado con un diente supernumerario (mesiodens) impactado en ...

  10. Correlación clínico-citohistológica de los quistes congénitos cervicales Clinical-cytohistological correlation of cervicofacial congenital cysts

    Directory of Open Access Journals (Sweden)

    L.D. Medina Vega

    2004-02-01

    Full Text Available Objetivo: Determinar la efectividad de los diagnósticos clínico y citológico en los quistes congénitos cervicofaciales. Método: Se realizó un estudio retrospectivo de los pacientes con diagnóstico clínico, citológico y/o histológico de quiste tirogloso, branquial y dermoide, atendidos en el Hospital Universitario «Arnaldo Milián Castro», durante cinco años. Se calculó la sensibilidad, especificidad y seguridad del diagnóstico clínico y la biopsia por aspiración con aguja fina (FNAC para cada quiste. Resultado: La seguridad del diagnóstico clínico fue de 94,1%, 92,2% y 98% para los quistes tirogloso branquial y dermoide respectivamente. Encontramos mayor tendencia al error clínico en los quistes branquiales, donde las confusiones más frecuentes se presentan con linfoadenopatías inflamatorias. La seguridad de la biopsia por aspiración con aguja fina fue de 96,1% y 94,1% para los quistes tirogloso y branquial respectivamente. Conclusiones: El diagnóstico clínico no es suficiente en ocasiones, por lo que es preciso recurrir a medios diagnósticos complementarios, como la biopsia por aspiración con aguja fina; sin embargo esta prueba no es 100% segura.Objective: To determine the effectiveness of clinical and cytological diagnosis in congenital cysts located in head and neck. Method: We were carried out a retrospective study of patients with clinical, cytological or histological diagnosis of thyroglossal, branchial and dermoid cyst, assisted in the University Hospital Arnaldo Milián Castro", during five years. It was calculated the sensibility, specificity and security of the clinical diagnosis and the Fine Needle Aspiration Biopsy for each cyst. Result: The security of the clinical diagnosis it was respectively of 94,1%, 92,2% and 98% for the thyroglossal, branchial and dermoid cysts. We find bigger tendency to the clinical error in branchial cysts, where the most frequent confusions are presented with inflammatory

  11. Estudio prospectivo de quistes de la lámina dental en neonatos venezolanos vih(+ y vih(-

    Directory of Open Access Journals (Sweden)

    Rodríguez-C

    2014-01-01

    Full Text Available Objetivo: Determinar la prevalencia de quistes de la lámina dental en un grupo de neonatos venezolanos VIH (+ y VIH (- verticalmente expuestos. Materiales y métodos: Estudio prospectivo, analítico y descriptivo. Se recolectaron datos en neonatos VIH(+ y VIH (- verticalmente expuestos. Fueron examinados clínicamente con la técnica rodilla a rodilla y con iluminación de la lámpara de la unidad dental. Se analizó la información general obtenida de las madres. El tratamiento de los datos se realizó mediante el Programa SPSS versión 11 de la escuela de Estadística y Actuario de la Facultad de Economía Universidad Central de Venezuela. Resultados: La población estuvo conformada por 62 neonatos 32 VIH (+ Y 30 VIH(-. La ocupación de la madre en su mayoría eran amas de casa, 68% procedía de Caracas, 57% pertenecían al género masculino, el motivo de consulta de los expuestos fue el control 72% y el de VIH(+ emergencias 88%, el 83% presentaron quistes, con un predominio en el reborde maxilar. Conclusión: Los resultados obtenidos nos permiten destacar la importancia de la participación del odontopediatra dentro del equipo interdisciplinario que atiende a neonatos así como destacar la importancia del examen bucal del recién nacido.

  12. Radiografía periapical como herramienta en el diagnóstico y tratamiento de quiste periapical

    Directory of Open Access Journals (Sweden)

    J. Verbel Bohórquez

    2015-02-01

    Full Text Available Introducción: El quiste periapical es una lesión inflamatoria común de los maxilares, que al alcanzar un tamaño significativo, causa deformidad del hueso afectado, retención o incluso el desplazamiento de dientes adyacentes. Se presentó caso de paciente que acudió a consulta odontológica, por presencia de sintomatología dolorosa durante el consumo de alimentos. Al examen clínico se observó encía adherida con presencia de inflamación y enrojecimiento a nivel de órgano dentario 14; radiográficamente se evidenció imagen radiolúcida unilocular, bien definida, abarcando dicho órgano dentario. La lesión fue eliminada quirúrgicamente con la posterior aplicación de material sellador. En el control postoperatorio se observó adecuado proceso de cicatrización y ausencia de sintomatología. Discusión: Se reporta caso de quiste periapical, que ocupaba el periápice de órgano dentario posterosuperior derecho. Radiográficamente se evidenció variabilidad mínima en el tamaño de la imagen. Se describe su resección quirúrgica y se informan los hallazgos de histopatología. En la revisión bibliográfica realizada se determinó la importancia de la elección de las radiografías periapicales en el área de endodoncia, y su papel en el diagnóstico, planificación de tratamiento y seguimiento de las piezas dentarias y tejidos circundantes comprometidos, pese a los inconvenientes de la técnica radiográfica.

  13. Fibroma ameloblástico versus quiste folicular hiperplásico Ameloblastic fibroma versus hyperplastic follicular cyst

    Directory of Open Access Journals (Sweden)

    J. Azúa-Romeo

    2004-06-01

    Full Text Available Resumen: El fibroma ameloblástico (FA es un tumor odontogénico mixto, compuesto por tejido mesenquimal y epitelio odontogénico, representando el 2% de los tumores odontogénicos, mientras que el quiste dentígero o folicular (QF, el segundo quiste odontogénico en frecuencia, está compuesto exclusivamente por tejido conjuntivo laxo (mesénquima, si bien, el saco fibroso puede contener restos de epitelio odontogénico incluidos, dando lugar a una imagen histológica muy similar. La importancia de esta diferenciación radica en el tratamiento, que es ligeramente más agresivo en el FA y en el comportamiento biológico, ya que el FA puede derivar en un sarcoma ameloblástico, y el QF puede evolucionar hacia ameloblastoma y más raramente carcinoma mucoepidermoide.Abstract: Ameloblastic fibroma (AF is a mixed odontogenic tumor composed of mesenchymal tissue and odontogenic epithelium, accounting for 2% of all odontogenic tumors, while dentigerous or follicular cyst (FQ, second odontogenic cyst in frequency, is formed exclusivelly by soft conective tissue (mesenchyme. Nevertheless, hiperplastic fibrous sac may contain rests of odontogenic epithelium, showing a similar histologic pattern. The importance of an adequate differentiation lies in the treatment, which is slightly aggresive for AF, and regarding the biological behaviour of both lesions, since AF might become in an ameloblastic sarcoma, while over an FQ could develope an ameloblastoma or even a mucoepidermoid carcinoma.

  14. Quiste óseo aneurismático Aneurysmal bone cyst

    Directory of Open Access Journals (Sweden)

    Ferdinando de Conto

    2012-06-01

    Full Text Available El quiste óseo aneurismático (QOA es una lesión benigna rara en huesos maxilares, su mayor frecuencia es en huesos largos del esqueleto y columna vertebral. Algunos autores especulan que el origen sea por trauma, mala formación o un neoplasma. El aspecto radiográfico puede mostrar desde una imagen difusa hasta una imagen bien definida, muy semejante a las otras lesiones de los maxilares volviendo el diagnóstico diferencial amplio. Con la destrucción del córtex óseo puede todavía formar una imagen reaccional del periostio en forma de rayos de sol, característico de una lesión maligna. En este estudio, se presenta caso de paciente femenino, 17 años de edad, que buscó el Servicio de Cirugía y Traumatología Buco maxilofacial del Hospital São Vicente de Paulo-RS, que presentó dolor y aumento de volumen en la mandíbula. Informó que hace cerca de un año empezó a sentir malestar en la región junto al ángulo mandibular derecho, lo cual fue progresivamente aumentando de volumen. El aspecto radiográfico acordaba una lesión maligna. Después de la confirmación histopatológica de QOA, el tratamiento seleccionado para el caso fue quirúrgico conservador, con legrado de la cavidad ósea, y fue mantenido en control posoperatorio de rutina con 6 y 18 meses. En las radiografías panorámicas realizadas se verifica la neoformación ósea y cura del caso.The aneurysmal bone cyst (ABC is a benign and rare lesion in maxillary bones, is more frequent in largo bones of skeletal and spinal column. Some authors speculate about that its origin be traumatic, malformation of neoplasm. The radiographic appearance may to show from a diffuse image up to a well defined image very similar to the other maxillary lesions turning wide the differential diagnosis. With destruction of the bon cortex it is possible to create a reaction image of periosteum in sunbeams characteristic of malignant lesion. This is the case of a female patient aged 17 seeking

  15. Quiste del colédoco como causa de dolor abdominal: revisión de un caso y bibliografía

    Directory of Open Access Journals (Sweden)

    Laura Arroyo Martínez

    2004-09-01

    Full Text Available El quiste del colédoco se define como la dilatación congénita o combinada del árbol biliar extrahepático (tipo más frecuente o intrahepático. La etiología no está aún determinada, pero existen tres teorías. Esta patología se observa en niños y adultos, predominantemente en mujeres. Pueden manifestarse anomalías en todo el sistema biliar, ya sea intra o extrahepático. Se clasifica en 5 tipos. Antes, el abordaje de dichos quistes era la cistoentero anastomosis, pero ahora se recomienda realizar una escisión completa del quiste, para disminuir el riesgo de malignidad y desarrollo de colangitis o pancreatitis recurrente. Aquí se presenta el caso de una mujer de 21 años con dolor abdominal, ictericia y una masa en el hipocondrío derecho, secundario a dicha patología, que fue sometida a una resección quirúrgica con anastomosis primaria. La evaluación anatomopatológica demostró una estructura quística de aspecto similar a una vesícula biliar, congestiva y pardusca, con inflamación crónica leve. Tuvo un postoperatorio satisfactorio y egresó con tratamiento antibiótico. El quiste coledociano debe considerarse en el diagnóstico diferencial de aquellos pacientes con dolor abdominal y masa en el cuadrante.

  16. Presentación de un quiste óseo aneurismático mandibular de gran tamaño: reporte de un caso y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    M.L. Marín Botero

    Full Text Available Un quiste es una cavidad patológica que puede contener una sustancia líquida, semilíquida o gaseosa. Aparecen como consecuencia de una reacción inflamatoria (quistes inflamatorios o por causa no conocida (quistes del desarrollo. Comúnmente la cavidad está recubierta por una cápsula constituida por un tejido conectivo subyacente y un epitelio en el lumen, excepto en los pseudoquistes que carecen de tejido epitelial, como es el caso que nos ocupa donde presentamos un paciente con quiste óseo aneurismático (QOA. Esta lesión se presenta con una frecuencia del 1,2% de los quistes maxilares y 2% de los que aparecen en todo el organismo. El objetivo de este trabajo es elaborar una revisión de la literatura y presentar un caso clínico de un paciente de 21 años de raza negra, masculino que consultó al servicio de cirugía maxilofacial de la Facultad de Odontología de la Universidad de Antioquia, por presentar un aumento de volumen en cuerpo mandibular derecho. Al examen radiográfico se encuentra una imagen radiolúcida de gran tamaño. Al paciente se le practicaron dos biopsias previas que dieron un diagnóstico distinto (tumor odontogénico queratoquístico y quiste radicular inflamatorio pero el diagnóstico definitivo del espécimen quirúrgico fue quiste óseo aneurismático (QOA. Se escribe su manejo y se hace una revisión de la literatura.

  17. Quiste de Gorlin asociado a Odontoma: reporte de un caso con su tratamiento quirúrgico Gorlin cyst associated with odontoma: Case report with surgical treatment

    Directory of Open Access Journals (Sweden)

    P. Villarroel Castro

    2005-12-01

    Full Text Available El quiste de Gorlin es un quiste odontogénico que puede presentarse en dos variedades, una quística rodeada por epitelio y de carácter benigno, y una neoplásica localmente agresiva. Se presenta elcaso de una mujer de 18 años con aumento de volumen facial indoloro en región infraorbitaria izquierda. Se realiza la exéresis total de la lesión. Con el estudio histopatológico se obtiene el diagnóstico definitivo de quiste de Gorlin asociado a odontoma. Luego de controles por 3 años, se observa el restablecimiento de la simetría facial, una adecuada regeneración ósea y de los tejidos adyacentes, sin signos de recidiva.Gorlin cyst is an odontogenic cyst that may appear as two types, one cystic and surrounded by epithelium of a benign nature, and the other a locally aggressive neoplasm. The case is presented of an 18-year-old female that had experienced an increase in facial volume in the left infraorbital area that was painless. Total exeresis of the lesion was carried out. The histopathologic study provided the definitive diagnosis of Gorlin cyst associated with odontoma. After a follow-up of three years, facial symmetry was reestablished, there was adequate regeneration of bone and of the adjacent tissue, and there were no signs of relapse.

  18. Infección experimental en el perro con quistes de Entamoeba coli asociados al estreptococo hemolítico por vía oral

    Directory of Open Access Journals (Sweden)

    Víctor M. Ayulo Robles

    1944-03-01

    Full Text Available El 94.1 % de los animales a los que les dimos en su alimentación quistes de Entamoeba coli, mezclados con cultivos de Estreptococo hemolítico y que recibieron un enema de retención, de la mezcla de cultivos en caldo de Estreptococo hemolítico más, bilis de buey, reprodujeron el cuadro agudo de la disentería amebiana, siendo las lesiones anátomo-patológicas e histológicas, semejantes a las obtenidas por otros autores, empleando para sus experiencias E. histolytica. El 100 % de los controles a los que se incluyó en su alimentación, solo cultivos de Estreptococo hemolítico y que recibieron un enema de retención de la mezcla de cultivo de Estreptococo y bilis de buey, hicieron un síndrome disenteriforme con un cuadro anátomo-patológico e histológico semejante a los que se les dió la mezcla de quistes de E. coli más Estreptococo hemolítico. En tanto que el 100 % de los que solamente recibieron en su dieta alimenticia quistes de E. coli, no presentaron en ningún momento, formas vegetativas de E. coli (en las heces y, a la autopsia, no revelaron lesión anátomopatológica alguna.

  19. LTR retrotransposons contribute to genomic gigantism in plethodontid salamanders.

    Science.gov (United States)

    Sun, Cheng; Shepard, Donald B; Chong, Rebecca A; López Arriaza, José; Hall, Kathryn; Castoe, Todd A; Feschotte, Cédric; Pollock, David D; Mueller, Rachel Lockridge

    2012-01-01

    Among vertebrates, most of the largest genomes are found within the salamanders, a clade of amphibians that includes 613 species. Salamander genome sizes range from ~14 to ~120 Gb. Because genome size is correlated with nucleus and cell sizes, as well as other traits, morphological evolution in salamanders has been profoundly affected by genomic gigantism. However, the molecular mechanisms driving genomic expansion in this clade remain largely unknown. Here, we present the first comparative analysis of transposable element (TE) content in salamanders. Using high-throughput sequencing, we generated genomic shotgun data for six species from the Plethodontidae, the largest family of salamanders. We then developed a pipeline to mine TE sequences from shotgun data in taxa with limited genomic resources, such as salamanders. Our summaries of overall TE abundance and diversity for each species demonstrate that TEs make up a substantial portion of salamander genomes, and that all of the major known types of TEs are represented in salamanders. The most abundant TE superfamilies found in the genomes of our six focal species are similar, despite substantial variation in genome size. However, our results demonstrate a major difference between salamanders and other vertebrates: salamander genomes contain much larger amounts of long terminal repeat (LTR) retrotransposons, primarily Ty3/gypsy elements. Thus, the extreme increase in genome size that occurred in salamanders was likely accompanied by a shift in TE landscape. These results suggest that increased proliferation of LTR retrotransposons was a major molecular mechanism contributing to genomic expansion in salamanders.

  20. Gigantic Surface Lifetime of an Intrinsic Topological Insulator

    Science.gov (United States)

    Neupane, Madhab; Xu, Su-Yang; Ishida, Yukiaki; Jia, Shuang; Fregoso, Benjamin M.; Liu, Chang; Belopolski, Ilya; Bian, Guang; Alidoust, Nasser; Durakiewicz, Tomasz; Galitski, Victor; Shin, Shik; Cava, Robert J.; Hasan, M. Zahid

    2015-09-01

    The interaction between light and novel two-dimensional electronic states holds promise to realize new fundamental physics and optical devices. Here, we use pump-probe photoemission spectroscopy to study the optically excited Dirac surface states in the bulk-insulating topological insulator Bi2Te2Se and reveal optical properties that are in sharp contrast to those of bulk-metallic topological insulators. We observe a gigantic optical lifetime exceeding 4 μ s (1 μ s =10-6 s ) for the surface states in Bi2Te2Se , whereas the lifetime in most topological insulators, such as Bi2Se3 , has been limited to a few picoseconds (1 ps =10-12 s ). Moreover, we discover a surface photovoltage, a shift of the chemical potential of the Dirac surface states, as large as 100 mV. Our results demonstrate a rare platform to study charge excitation and relaxation in energy and momentum space in a two-dimensional system.

  1. Onfalocele gigante roto. Presentación de un caso

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    Víctor Manuel González Valdez

    2013-10-01

    Full Text Available El onfalocele es uno de los defectos de la pared abdominal. Puede asociarse a otras malformaciones como el ano imperforado, agenesia del colon, extrofia vesical y afecciones cardiovasculares, que a menudo devienen fetos no viables. Se presenta el caso de una recién nacida en Belize, de parto pretérmino (35,3 semanas, con bajo peso (1860 g y primogénita, que requirió cirugía de urgencia a las diez horas de vida por onfalocele gigante roto, asociado a tetralogía de Fallot, hipoglucemia y gran toma del estado general. El objetivo del informe es exponer los procederes diagnósticos y terapéuticos en este tipo de casos. Dado el adecuado diagnóstico prenatal que existe en Cuba, es inusual que los médicos cubanos, salvo aquellos que colaboran en el extranjero, asistan a estos pacientes; por ello, este trabajo puede ser útil en el contexto docente.

  2. [Active acromegaly and gigantism: some clinical characteristics of 50 patients].

    Science.gov (United States)

    Pumarino, H; Oviedo, S; Michelsen, H; Campino, C

    1991-08-01

    50 patients with autonomous growth hormone excess (48 with adult acromegaly and 2 with gigantism) were studied between 1966 to 1986 (2.38 pts/year). Characteristic clinical presentation, an increase in growth hormone (GH) uninhibited by glucose, and/or hyperphosphemia and hyperhydroxiprolinuria were present in all patients. No cases of hypercalcemia were recorded. Phosphemia was increased in 55.8%, alkaline phosphatases in 61.7%, calciuria in 26.9% and hydroxyprolinuria in 74.2% of the patients. Basal GH was over 5 ng/ml (89.9 DS +/- 170.9) in 42 pts, and in 37 was not suppressed after glucose administration, 38% had an increased (paradoxical response) and 62% a flat response (less than 50% change of basal values). TRH test was performed in 14 patients, 8 presented an increase in GH titer. Hyperprolactinemia was seen in 4 of 12 patients in whom this hormone was measured. The size of the sella turcica was increased in 93%, and although the larger sellar size correlated to higher levels of GH, correlation was not significant. 20% of the pts had rheumatological disease, 14% goiter, 12% cardiac disease, 26.5% had diastolic hypertension and 4% renal lithiasis (hypercalciuric pts). 38% had hyperglycemia with a diabetic glucose tolerance test and 18% had non-diabetic abnormal glucose tolerance test.

  3. Towards the Gigantic: Entification and Standardization as Technologies of Control

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    Petter G. Almklov

    2012-12-01

    Full Text Available This paper is based on studies of how standardized entities work as elements in a regime to control risk and hazardous work. Drawing on empirical examples from the petroleum industry and infrastructure sectors, we illustrate not only the mech-anisms by which particular modes of entification are involved in regimes of con-trol but also their shortcomings and seductive powers as representations. We show how the world is semantically captured and organized to consist of controllable standardized entities by the organizational regimes in the industries we have stud-ied. This mode of entification is particularly effective in providing transcontextual mobility, as the registered entities can enter the ever-expanding information infra-structures of modernity. Although information infrastructures comprise the stand-ards regulating communication, they commonly materialize in information and communication technologies (ICT that provide an increasing number of effective and ubiquitous pathways through which standardized semantic signs can move and have effects. This is a core concern in the increasing focus on management by detailed regimes of accountability, measurement and standardization seen in most modern organizations. These developments, combined with the representational shortcomings of the standardized entifications, lead to a movement towards the gigantic. An ever-increasing number of signs with increasingly higher granularity are produced in order to control an ever-elusive non-entified world.

  4. Enucleación de quiste periapical simultáneo a la obturación del sistema de conductos radiculares

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    Lida Velazque

    Full Text Available Introducción: los quistes periapicales representan el tipo más frecuente dentro de los quistes odontogénicos. Su origen está relacionado con una necrosis pulpar y un consecuente estímulo de los restos epiteliales del ligamento periodontal (Malassez. Objetivo: describir un caso clínico de enucleación de quiste periapical simultáneo a la obturación del sistema de conductos radiculares. Presentación del caso: paciente de sexo femenino, 67 años de edad, sin alteraciones sistémicas; buscó atención odontológica por presentar dolor dental y acúmulo de alimentos en la región de molares inferiores del lado izquierdo. Al examen clínico se observó caries extensa en el segundo molar inferior izquierdo con compromiso de furca, ausencia de aumento de volumen vestibular, sin fistula; en la radiografía periapical se evidenció lesión cariosa extensa recidivante en el segundo molar inferior izquierdo, y primer molar inferior izquierdo con tratamiento endodóntico y presencia de área radiolúcida de contornos bien definidos en la región periapical compatible con quiste periapical. El tratamiento estuvo a cargo de un equipo multidisciplinario por lo que se decidió realizar exodoncia del segundo molar inferior izquierdo y cirugía paraendodóntica con enucleación quirúrgica simultánea a la obturación del sistema de conductos radiculares primer molar inferior izquierdo; el examen histopatológico de la muestra extraída comprobó tratarse de un quiste periapical. Se realizó seguimiento radiográfico dos años después y mostró un completo reparo óseo del área afectada. Conclusiones: se concluye que el tratamiento descrito constituye una alternativa válida para la resolución de casos donde la endodoncia convencional es limitada para mantener la función y estética de una pieza dentaria.

  5. Opciones terapéuticas en quistes odontogénicos: Revisión Therapeutic options in odontogenic cyst: Review

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    A. Vega Llauradó

    2013-04-01

    Full Text Available Los huesos maxilares constituyen asiento de una gran variedad de quistes y neoplasias que pueden ser de difícil diagnóstico. De entre todos los procesos tumorales que se dan en el territorio maxilofacial, los quistes son de gran importancia debido a la frecuencia de su presentación. Los quistes maxilares tienen distinto origen y comportamiento clínico. A partir de la clasificación de la OMS de 1992, esta revisión estudia las características clínicas, radiográficas y epidemiológicas de los quistes del desarrollo odontógenos. Una adecuada exploración clínica y radiográfica por parte del odontólogo es suficiente para alcanzar un diagnóstico de presunción. Las consideraciones clínicas y terapéuticas de cada uno de estos quistes son variables, por lo que es necesario conocer el comportamiento epidemiológico de ellos. El diagnóstico de presunción, el tamaño de la lesión y la relación de esta con estructuras anatómicas vecinas condicionará el tipo de tratamiento. El diagnóstico definitivo lo dictaminará el análisis anatomopatológico.The maxillary bones constitute the base of a big variety of cyst and tumours that can be difficult to diagnose. Among all the tumor processes that can occur in the maxillofacial area, cysts are of the utmost importance due to their frequency. Jaw cysts have different origins and clinical behavior. After the OMS classification in 1992, this review examines the clinical, radiographic and epidemiological characteristics of the cyst of the odontogenic development. An appropriate clinical and radiographic exploration on the part of the dentist is enough to reach a presumptive diagnosis. The clinical and therapeutic considerations of each of these cysts are variable, so it is necessary to know their epidemiological behavior. The presumptive diagnosis, the size of the cyst and its relationship with neighboring anatomical structures will determine the type of treatment. The definitive diagnosis will

  6. Why might they be giants? Towards an understanding of polar gigantism.

    Science.gov (United States)

    Moran, Amy L; Woods, H Arthur

    2012-06-15

    Beginning with the earliest expeditions to the poles, over 100 years ago, scientists have compiled an impressive list of polar taxa whose body sizes are unusually large. This phenomenon has become known as 'polar gigantism'. In the intervening years, biologists have proposed a multitude of hypotheses to explain polar gigantism. These hypotheses run the gamut from invoking release from physical and physiological constraints, to systematic changes in developmental trajectories, to community-level outcomes of broader ecological and evolutionary processes. Here we review polar gigantism and emphasize two main problems. The first is to determine the true strength and generality of this pattern: how prevalent is polar gigantism across taxonomic units? Despite many published descriptions of polar giants, we still have a poor grasp of whether these species are unusual outliers or represent more systematic shifts in distributions of body size. Indeed, current data indicate that some groups show gigantism at the poles whereas others show nanism. The second problem is to identify underlying mechanisms or processes that could drive taxa, or even just allow them, to evolve especially large body size. The contenders are diverse and no clear winner has yet emerged. Distinguishing among the contenders will require better sampling of taxa in both temperate and polar waters and sustained efforts by comparative physiologists and evolutionary ecologists in a strongly comparative framework.

  7. Quiste broncogénico: presentación de un caso en el período neonatal = Bronchogenic cyst: report of a case in the neonatal period

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    Morales Múnera, Olga Lucía

    2010-12-01

    Full Text Available El quiste broncogénico es una malformación de la pared ventral del intestino primitivo que genera alteraciones en el desarrollo del árbol traqueobronquial. Presentamos el caso de un varón recién nacido con un quiste broncogénico en el lóbulo superior derecho, remitido a la unidad de cuidados intensivos neonatales del Hospital Universitario San Vicente de Paúl, de Medellín, por dificultad respiratoria progresiva y quiste torácico congénito. El tratamiento quirúrgico -lobectomía- fue exitoso.Los quistes brocogénicos son un grupo heterogéneo; pueden ser únicos o múltiples y generalmente están confinados a un segmento o lóbulo pulmonar; su sintomatología se debe a compresión o sobreinfección y depende del lugar y el tamaño del quiste; el tratamiento de elección es el quirúrgico aun en pacientes asintomáticos.

  8. Revisión analítica de los quistes odontogénicos: Archivo de la Cátedra de Anatomía Patológica Facultad de Odontología UdelaR

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    Myriam Fungi Monetti

    Full Text Available Se realizó una revisión analítica de los quistes odontogénicos del Archivo de la Cátedra de Anatomía Patológica de la Facultad de Odontología UdelaR en el período 1956 – 2006, teniendo en cuenta los criterios actuales de la O.M.S. Se consideraron las siguientes variables: tipo de quiste, edad, género y topografía. En un total de 10.878 biopsias se hallaron 1.317 quistes odontogénicos que constituyeron el 12,1 % del total de biopsias, siendo los infl amatorios el 89 % y los de desarrollo 11 %. La edad promedio de los pacientes con quistes inflamatorios se situó en 32,09 años y los de desarrollo 31,12 años. Los quistes inflamatorios fueron más frecuentes en hombres que en mujeres 1.24:1 y 1.49:1 en los de desarrollo. En cuanto a la localización, los infl amatorios se ubican más en el maxilar superior y los de desarrollo en el maxilar inferior. Los resultados obtenidos se compararon con otras casuísticas publicadas

  9. Biology of the sauropod dinosaurs: the evolution of gigantism.

    Science.gov (United States)

    Sander, P Martin; Christian, Andreas; Clauss, Marcus; Fechner, Regina; Gee, Carole T; Griebeler, Eva-Maria; Gunga, Hanns-Christian; Hummel, Jürgen; Mallison, Heinrich; Perry, Steven F; Preuschoft, Holger; Rauhut, Oliver W M; Remes, Kristian; Tütken, Thomas; Wings, Oliver; Witzel, Ulrich

    2011-02-01

    The herbivorous sauropod dinosaurs of the Jurassic and Cretaceous periods were the largest terrestrial animals ever, surpassing the largest herbivorous mammals by an order of magnitude in body mass. Several evolutionary lineages among Sauropoda produced giants with body masses in excess of 50 metric tonnes by conservative estimates. With body mass increase driven by the selective advantages of large body size, animal lineages will increase in body size until they reach the limit determined by the interplay of bauplan, biology, and resource availability. There is no evidence, however, that resource availability and global physicochemical parameters were different enough in the Mesozoic to have led to sauropod gigantism. We review the biology of sauropod dinosaurs in detail and posit that sauropod gigantism was made possible by a specific combination of plesiomorphic characters (phylogenetic heritage) and evolutionary innovations at different levels which triggered a remarkable evolutionary cascade. Of these key innovations, the most important probably was the very long neck, the most conspicuous feature of the sauropod bauplan. Compared to other herbivores, the long neck allowed more efficient food uptake than in other large herbivores by covering a much larger feeding envelope and making food accessible that was out of the reach of other herbivores. Sauropods thus must have been able to take up more energy from their environment than other herbivores. The long neck, in turn, could only evolve because of the small head and the extensive pneumatization of the sauropod axial skeleton, lightening the neck. The small head was possible because food was ingested without mastication. Both mastication and a gastric mill would have limited food uptake rate. Scaling relationships between gastrointestinal tract size and basal metabolic rate (BMR) suggest that sauropods compensated for the lack of particle reduction with long retention times, even at high uptake rates. The

  10. Cisto gigante de colédoco Giant choledochal cyst

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    Olival Cirilo Lucena da Fonseca-Neto

    2007-12-01

    Full Text Available INTRODUÇÃO: A doença cística das vias biliares é anomalia congênita que pode acometer as vias biliares intra e/ou extra-hepáticas. A extra-hepática inclui os cistos de colédoco e a intra-hepática é conhecida por Doença de Caroli. Os cistos de colédoco de tamanho gigante são muito raros. OBJETIVO: Relatar o caso de um cisto de colédoco de tamanho gigante em uma paciente feminina. RELATO DE CASO: Mulher de 19 anos foi admitida com história de icterícia e acolia fecal há sete dias. Referia dor epigástrica associada com ingestão de dieta rica em gordura. Nos antecedentes pessoais relatou dois episódios de icterícia, aos 8 e 14 anos, que progrediram espontaneamente. No exame físico apresentava icterícia (+3/+4 e uma massa palpável indolor em mesogástrio foram os únicos achados. A ultrassonografia demonstrou grande formação cística de paredes finas adjacente ao hepatocolédoco, pâncreas e rim direito que media 18,5 x 10,2 cm. A colangioressonância confirmou o grande cisto de colédoco e hepatojejunoanastomose em "Y" de Roux após excisão do cisto e colecistectomia foi realizada. A formação cística media 20 x 15,5 x 12,5 cm e com um volume médio de 1000 mL. A paciente encontra-se em acompanhamento ambulatorial sem alterações hepatobiliares após o sétimo mês da operação. CONCLUSÃO: O cisto de colédoco deve fazer parte do diagnóstico diferencial em pacientes adultos jovens com icterícia e massa palpável; no entanto, a diferenciação entre ele e neoplasia maligna deve ser pesquisada.BACKGROUND: Choledochal cyst represents a rare congenital anomaly, eventually associated with intra and extrahepatic biliary tract disorders. Extrahepatic diseases include choledochal cysts and congenital dilation of the lower intrahepatic bile duct is known as Caroli's disease. Giant choledochal cyst constitutes a very rare abnormality. AIM:To report a giant choledochal cyst in a female patient. CASE REPORT: A 19-year

  11. Biology of the sauropod dinosaurs: the evolution of gigantism

    Science.gov (United States)

    Sander, P Martin; Christian, Andreas; Clauss, Marcus; Fechner, Regina; Gee, Carole T; Griebeler, Eva-Maria; Gunga, Hanns-Christian; Hummel, Jürgen; Mallison, Heinrich; Perry, Steven F; Preuschoft, Holger; Rauhut, Oliver W M; Remes, Kristian; Tütken, Thomas; Wings, Oliver; Witzel, Ulrich

    2011-01-01

    The herbivorous sauropod dinosaurs of the Jurassic and Cretaceous periods were the largest terrestrial animals ever, surpassing the largest herbivorous mammals by an order of magnitude in body mass. Several evolutionary lineages among Sauropoda produced giants with body masses in excess of 50 metric tonnes by conservative estimates. With body mass increase driven by the selective advantages of large body size, animal lineages will increase in body size until they reach the limit determined by the interplay of bauplan, biology, and resource availability. There is no evidence, however, that resource availability and global physicochemical parameters were different enough in the Mesozoic to have led to sauropod gigantism. We review the biology of sauropod dinosaurs in detail and posit that sauropod gigantism was made possible by a specific combination of plesiomorphic characters (phylogenetic heritage) and evolutionary innovations at different levels which triggered a remarkable evolutionary cascade. Of these key innovations, the most important probably was the very long neck, the most conspicuous feature of the sauropod bauplan. Compared to other herbivores, the long neck allowed more efficient food uptake than in other large herbivores by covering a much larger feeding envelope and making food accessible that was out of the reach of other herbivores. Sauropods thus must have been able to take up more energy from their environment than other herbivores. The long neck, in turn, could only evolve because of the small head and the extensive pneumatization of the sauropod axial skeleton, lightening the neck. The small head was possible because food was ingested without mastication. Both mastication and a gastric mill would have limited food uptake rate. Scaling relationships between gastrointestinal tract size and basal metabolic rate (BMR) suggest that sauropods compensated for the lack of particle reduction with long retention times, even at high uptake rates. The

  12. [Complex ultrasonic diagnosis of large and gigantic non-parasitic cysts of liver].

    Science.gov (United States)

    Kuntsevich, G I; Gavrilin, A V; Vishnevskiĭ, V A; Zhurenkova, T V; Chebysheva, E N; Zhavoronkova, O I; Agafonov, V A

    2007-01-01

    The results of clinical and complex ultrasonic examination of 95 patients with large and gigantic liver non-parasitic cysts (LNC) are analyzed. The morphological examination was performed in all the cases. The mean diameter of large LNC was 105+/-7 mm, of gigantic cysts -- 149+/-33 mm (p<0,05), cyst volume was respectively 600+/-142 and 1721+/-954 ml (p<0,05). Analysis of clinical, ultrasonic and laboratory data allowed to describe three variants of large and gigantic, complicated and non-complicated cysts with 97,9% accuracy. The 3-D US reconstruction permitted to precise the anatomic structure and trace selection during transcutaneous US-assisted treatment.

  13. Corticoides intralesionales en lesiones a células gigantes

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    J.P. Crestanello Nese

    2003-12-01

    Full Text Available Desde su descripción original, las lesiones de células gigantes (LCG han sido entidades controvertidas, desde el punto de vista de su origen, de su comportamiento clínico, de sus características radiográficas e histológicas, así como de su tratamiento. Para su tratamiento se han considerado alternativas quirúrgicas y no quirúrgicas. En este trabajo, se presentan tres nuevos casos de LCG, en los cuales se realizó infiltración intralesional con corticoides como una maniobra previa y complementaria a la quirúrgica. Luego de la infiltración, se observó una disminución del tamaño de las lesiones y un cambio en sus características macroscópicas, se trato por enucleación un caso y por remodelación quirúrgica los dos restantes.Giant cell lesions (GCL have been controversial entities since its original description. Its origin, clinical behavior, radiographic and histological features and also its treatment are polemical. The therapeutic possibilities are surgical or non surgical. In this paper, the intralesional infiltration with steroids is presented like a previous and complementary therapy to surgery alone. Three new cases of GCL are presented. All of them were first treated with intralesional infiltration with steroids. After that,a partial remission and a change of the macroscopic characteristics were observed and one of the lesion was then enucleated while for the others two surgical remodelation were necessary to do.

  14. Slow DNA loss in the gigantic genomes of salamanders.

    Science.gov (United States)

    Sun, Cheng; López Arriaza, José R; Mueller, Rachel Lockridge

    2012-01-01

    Evolutionary changes in genome size result from the combined effects of mutation, natural selection, and genetic drift. Insertion and deletion mutations (indels) directly impact genome size by adding or removing sequences. Most species lose more DNA through small indels (i.e., ~1-30 bp) than they gain, which can result in genome reduction over time. Because this rate of DNA loss varies across species, small indel dynamics have been suggested to contribute to genome size evolution. Species with extremely large genomes provide interesting test cases for exploring the link between small indels and genome size; however, most large genomes remain relatively unexplored. Here, we examine rates of DNA loss in the tetrapods with the largest genomes-the salamanders. We used low-coverage genomic shotgun sequence data from four salamander species to examine patterns of insertion, deletion, and substitution in neutrally evolving non-long terminal repeat (LTR) retrotransposon sequences. For comparison, we estimated genome-wide DNA loss rates in non-LTR retrotransposon sequences from five other vertebrate genomes: Anolis carolinensis, Danio rerio, Gallus gallus, Homo sapiens, and Xenopus tropicalis. Our results show that salamanders have significantly lower rates of DNA loss than do other vertebrates. More specifically, salamanders experience lower numbers of deletions relative to insertions, and both deletions and insertions are skewed toward smaller sizes. On the basis of these patterns, we conclude that slow DNA loss contributes to genomic gigantism in salamanders. We also identify candidate molecular mechanisms underlying these differences and suggest that natural variation in indel dynamics provides a unique opportunity to study the basis of genome stability.

  15. Aneurisma gigante parasselar simulando tumor de hipófise

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    Luiz Augusto Casulari Roxo da Motta

    1988-12-01

    Full Text Available Revisamos 7 pacientes com comprometimento da sela turca ao raio X do crânio que apresentavam aneurisma gigante da porção intracavernosa da artéria carótida (6 casos e aneurisma da artéria comunicante anterior (1 caso. As alterações encontradas foram: cefaléia (7/7, oftalmoplegia complexa interessando III, IV e VI nervos cranianos (5/7 e comprometimento do V nervo (4/7, dor ocular (4/7. Outras alterações encontradas foram: sinais meníngeos (2/7, cegueira unilateral (1/7, hemiparesia (1/7 cacosmia (1/7 e quadrantanopsia bitemporal inferior (1/7. Cinco pacientes com aneurisma da porção intracavernosa da artéria carótida beneficiaram-se com a ligadura progressiva da artéria carótida interna a nível cervical; o outro paciente faleceu antes da realização da operação. O paciente com aneurisma da artéria comunicante anterior foi submetido a clipagem do aneurisma, tendo boa evolução. Baseados neste estudo e em concordância com a literatura, concluímos que o diagnóstico diferencial entre aneurisma localizado na região parasselar e outras patologias dessa área freqüentemente apresenta dificuldade. O diagnóstico definitivo requer a realização de angiografia cerebral. O tratamento cirúrgico, por ligadura da carótida interna na região cervical, é benéfico e quase desprovido de complicações.

  16. An evolutionary cascade model for sauropod dinosaur gigantism--overview, update and tests.

    Science.gov (United States)

    Sander, P Martin

    2013-01-01

    Sauropod dinosaurs are a group of herbivorous dinosaurs which exceeded all other terrestrial vertebrates in mean and maximal body size. Sauropod dinosaurs were also the most successful and long-lived herbivorous tetrapod clade, but no abiological factors such as global environmental parameters conducive to their gigantism can be identified. These facts justify major efforts by evolutionary biologists and paleontologists to understand sauropods as living animals and to explain their evolutionary success and uniquely gigantic body size. Contributions to this research program have come from many fields and can be synthesized into a biological evolutionary cascade model of sauropod dinosaur gigantism (sauropod gigantism ECM). This review focuses on the sauropod gigantism ECM, providing an updated version based on the contributions to the PLoS ONE sauropod gigantism collection and on other very recent published evidence. The model consist of five separate evolutionary cascades ("Reproduction", "Feeding", "Head and neck", "Avian-style lung", and "Metabolism"). Each cascade starts with observed or inferred basal traits that either may be plesiomorphic or derived at the level of Sauropoda. Each trait confers hypothetical selective advantages which permit the evolution of the next trait. Feedback loops in the ECM consist of selective advantages originating from traits higher in the cascades but affecting lower traits. All cascades end in the trait "Very high body mass". Each cascade is linked to at least one other cascade. Important plesiomorphic traits of sauropod dinosaurs that entered the model were ovipary as well as no mastication of food. Important evolutionary innovations (derived traits) were an avian-style respiratory system and an elevated basal metabolic rate. Comparison with other tetrapod lineages identifies factors limiting body size.

  17. An evolutionary cascade model for sauropod dinosaur gigantism--overview, update and tests.

    Directory of Open Access Journals (Sweden)

    P Martin Sander

    Full Text Available Sauropod dinosaurs are a group of herbivorous dinosaurs which exceeded all other terrestrial vertebrates in mean and maximal body size. Sauropod dinosaurs were also the most successful and long-lived herbivorous tetrapod clade, but no abiological factors such as global environmental parameters conducive to their gigantism can be identified. These facts justify major efforts by evolutionary biologists and paleontologists to understand sauropods as living animals and to explain their evolutionary success and uniquely gigantic body size. Contributions to this research program have come from many fields and can be synthesized into a biological evolutionary cascade model of sauropod dinosaur gigantism (sauropod gigantism ECM. This review focuses on the sauropod gigantism ECM, providing an updated version based on the contributions to the PLoS ONE sauropod gigantism collection and on other very recent published evidence. The model consist of five separate evolutionary cascades ("Reproduction", "Feeding", "Head and neck", "Avian-style lung", and "Metabolism". Each cascade starts with observed or inferred basal traits that either may be plesiomorphic or derived at the level of Sauropoda. Each trait confers hypothetical selective advantages which permit the evolution of the next trait. Feedback loops in the ECM consist of selective advantages originating from traits higher in the cascades but affecting lower traits. All cascades end in the trait "Very high body mass". Each cascade is linked to at least one other cascade. Important plesiomorphic traits of sauropod dinosaurs that entered the model were ovipary as well as no mastication of food. Important evolutionary innovations (derived traits were an avian-style respiratory system and an elevated basal metabolic rate. Comparison with other tetrapod lineages identifies factors limiting body size.

  18. Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation

    Science.gov (United States)

    Trivellin, G.; Daly, A.F.; Faucz, F.R.; Yuan, B.; Rostomyan, L.; Larco, D.O.; Schernthaner-Reiter, M.H.; Szarek, E.; Leal, L.F.; Caberg, J.-H.; Castermans, E.; Villa, C.; Dimopoulos, A.; Chittiboina, P.; Xekouki, P.; Shah, N.; Metzger, D.; Lysy, P.A.; Ferrante, E.; Strebkova, N.; Mazerkina, N.; Zatelli, M.C.; Lodish, M.; Horvath, A.; de Alexandre, R. Bertollo; Manning, A.D.; Levy, I.; Keil, M.F.; de la Luz Sierra, M.; Palmeira, L.; Coppieters, W.; Georges, M.; Naves, L.A.; Jamar, M.; Bours, V.; Wu, T.J.; Choong, C.S.; Bertherat, J.; Chanson, P.; Kamenický, P.; Farrell, W.E.; Barlier, A.; Quezado, M.; Bjelobaba, I.; Stojilkovic, S.S.; Wess, J.; Costanzi, S.; Liu, P.; Lupski, J.R.; Beckers, A.; Stratakis, C.A.

    2015-01-01

    BACKGROUND Increased secretion of growth hormone leads to gigantism in children and acromegaly in adults; the genetic causes of gigantism and acromegaly are poorly understood. METHODS We performed clinical and genetic studies of samples obtained from 43 patients with gigantism and then sequenced an implicated gene in samples from 248 patients with acromegaly. RESULTS We observed microduplication on chromosome Xq26.3 in samples from 13 patients with gigantism; of these samples, 4 were obtained from members of two unrelated kindreds, and 9 were from patients with sporadic cases. All the patients had disease onset during early childhood. Of the patients with gigantism who did not carry an Xq26.3 microduplication, none presented before the age of 5 years. Genomic characterization of the Xq26.3 region suggests that the microduplications are generated during chromosome replication and that they contain four protein-coding genes. Only one of these genes, GPR101, which encodes a G-protein–coupled receptor, was overexpressed in patients’ pituitary lesions. We identified a recurrent GPR101 mutation (p.E308D) in 11 of 248 patients with acromegaly, with the mutation found mostly in tumors. When the mutation was transfected into rat GH3 cells, it led to increased release of growth hormone and proliferation of growth hormone–producing cells. CONCLUSIONS We describe a pediatric disorder (which we have termed X-linked acrogigantism [X-LAG]) that is caused by an Xq26.3 genomic duplication and is characterized by early-onset gigantism resulting from an excess of growth hormone. Duplication of GPR101 probably causes X-LAG. We also found a recurrent mutation in GPR101 in some adults with acromegaly. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and others.) PMID:25470569

  19. Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.

    Science.gov (United States)

    Trivellin, Giampaolo; Daly, Adrian F; Faucz, Fabio R; Yuan, Bo; Rostomyan, Liliya; Larco, Darwin O; Schernthaner-Reiter, Marie Helene; Szarek, Eva; Leal, Letícia F; Caberg, Jean-Hubert; Castermans, Emilie; Villa, Chiara; Dimopoulos, Aggeliki; Chittiboina, Prashant; Xekouki, Paraskevi; Shah, Nalini; Metzger, Daniel; Lysy, Philippe A; Ferrante, Emanuele; Strebkova, Natalia; Mazerkina, Nadia; Zatelli, Maria Chiara; Lodish, Maya; Horvath, Anelia; de Alexandre, Rodrigo Bertollo; Manning, Allison D; Levy, Isaac; Keil, Margaret F; Sierra, Maria de la Luz; Palmeira, Leonor; Coppieters, Wouter; Georges, Michel; Naves, Luciana A; Jamar, Mauricette; Bours, Vincent; Wu, T John; Choong, Catherine S; Bertherat, Jerome; Chanson, Philippe; Kamenický, Peter; Farrell, William E; Barlier, Anne; Quezado, Martha; Bjelobaba, Ivana; Stojilkovic, Stanko S; Wess, Jurgen; Costanzi, Stefano; Liu, Pengfei; Lupski, James R; Beckers, Albert; Stratakis, Constantine A

    2014-12-18

    Increased secretion of growth hormone leads to gigantism in children and acromegaly in adults; the genetic causes of gigantism and acromegaly are poorly understood. We performed clinical and genetic studies of samples obtained from 43 patients with gigantism and then sequenced an implicated gene in samples from 248 patients with acromegaly. We observed microduplication on chromosome Xq26.3 in samples from 13 patients with gigantism; of these samples, 4 were obtained from members of two unrelated kindreds, and 9 were from patients with sporadic cases. All the patients had disease onset during early childhood. Of the patients with gigantism who did not carry an Xq26.3 microduplication, none presented before the age of 5 years. Genomic characterization of the Xq26.3 region suggests that the microduplications are generated during chromosome replication and that they contain four protein-coding genes. Only one of these genes, GPR101, which encodes a G-protein-coupled receptor, was overexpressed in patients' pituitary lesions. We identified a recurrent GPR101 mutation (p.E308D) in 11 of 248 patients with acromegaly, with the mutation found mostly in tumors. When the mutation was transfected into rat GH3 cells, it led to increased release of growth hormone and proliferation of growth hormone-producing cells. We describe a pediatric disorder (which we have termed X-linked acrogigantism [X-LAG]) that is caused by an Xq26.3 genomic duplication and is characterized by early-onset gigantism resulting from an excess of growth hormone. Duplication of GPR101 probably causes X-LAG. We also found a recurrent mutation in GPR101 in some adults with acromegaly. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and others.).

  20. Diagnóstico y tratamiento de los quistes de colédoco: Presentación de 10 nuevos casos Diagnosis and management of choledochal cysts: A review of 10 new cases

    OpenAIRE

    2008-01-01

    Objetivo: analizar las técnicas diagnósticas y las distintas posibilidades terapéuticas de esta rara patología. Pacientes y métodos: presentamos un estudio retrospectivo de todos los casos de quistes de colédoco diagnosticados en nuestro hospital desde 1991. Incluye 10 nuevos casos y distintos tipos de quistes de colédoco (QC). Resultados: de los 10 pacientes diagnosticados de QC siete tenían menos de 10 años. En cuanto a los diferentes tipos de QC: 7 eran de tipo I, 1 de tipo III, 1 de tipo ...

  1. PANCREATITIS AGUDA COMO PRESENTACIÓN DE UN QUISTE DEL CONDUCTO BILIAR EN EL ADULTO: REPORTE DE CASO Acute pancreatitis as a presentation of bile duct cyst in adults: a case report

    OpenAIRE

    Lenin Enríquez Domínguez; Juan de Dios Díaz Rosales; Enrique Cabrera Hinojosa; Pedro Gutiérrez Ramírez; Baltazar Aguayo Muñoz

    2009-01-01

    Paciente adulta se presentÓ en la sala de urgencias con un cuadro de pancreatitis aguda como complicaciÓn de un quiste del conducto biliar colédoco tipo IV, el cual fue diagnosticado por ultrasonograma abdominal durante su estancia intrahospitalaria. El diagnÓstico de quiste de colédoco es más difícil en la edad adulta ya que los pacientes raramente se presentan con la triada clásica de dolor abdominal, masa palpable e ictericia, presentándose principalmente con alguna manifestaciÓn de vías b...

  2. Quiste dentígero: diagnóstico y resolución de un caso. Revisión de la literatura Dentigerous cyst: diagnosis and resolution of a case. A review of the literature

    OpenAIRE

    J. Vázquez Diego; C. Gandini Pablo; E. Carvajal Eduardo

    2008-01-01

    Se presenta un caso clínico de quiste dentígero asociado a un segundo premolar inferior derecho retenido. El paciente de 13 años de edad es de sexo masculino. Se utilizan las técnicas radiográficas extraoral lateral oblicua de rama y la intraoral del paralelo para poder localizar y diagnosticar presuntivamente dicha patología. Posteriormente se realiza la intervención quirúrgica para realizar la extracción del diente retenido y la enucleación del quiste el que es enviado para realizar los est...

  3. TUMOR BORDERLINE MUCINOSO OVÁRICO GIGANTE CON MICROINVASIÓN

    OpenAIRE

    Rivera Z,René; Barrero P,Raúl; García M,Gladys; Barrero V.,David; Larraín H,Angélica

    2006-01-01

    Se presenta caso clínico de tumor borderline mucinoso gigante de ovario derecho operado. Se describe una breve revisión de la literatura, incluyendo los conceptos de microinvasión, arquitectura micropapilar, implantes, así como algunas características de su patogenia y tratamiento

  4. Spontaneous remission of acromegaly or gigantism due to subclinical apoplexy of pituitary growth hormone adenoma

    Institute of Scientific and Technical Information of China (English)

    WANG Xian-ling; DOU Jing-tao; L(U) Zhao-hui; ZHONG Wen-wen; BA Jian-ming; JIN Du; LU Ju-ming; PAN Chang-yu; MU Yi-ming

    2011-01-01

    Background Subclinical apoplexy of pituitary functional adenoma can cause spontaneous remission of hormone hypersecretion.The typical presence of pituitary growth hormone (GH) adenoma is gigantism and/or acromegaly.We investigated the clinical characteristics of patients with spontaneous partial remission of acromegaly or gigantism due to subclinical apoplexy of GH adenoma.Methods Six patients with spontaneous remission of acromegaly or gigantism were enrolled.The clinical characteristics,endocrinological evaluation and imageological characteristics were retrospectively analyzed.Results In these cases,the initial clinical presences were diabetes mellitus or hypogonadism.No abrupt headache,vomiting,visual function impairment,or conscious disturbance had ever been complained of.The base levels of GH and insulin growth factor-1 (IGF-1) were normal or higher,but nadir GH levels were all still >1 μg/L in 75 g oral glucose tolerance test.Magnetic resonance imaging detected enlarged sella,partial empty sella and compressed pituitary.The transsphenoidal surgery was performed in 2 cases,and the other patients were conservatively managed.All the patients were in clinical remission.Conclusions When the clinical presences,endocrine evaluation,biochemical examination and imageology indicate spontaneous remission of GH hypersecretion in patients with gigantism or acromegaly,the diagnosis of subclinical apoplexy of pituitary GH adenoma should be presumed.To these patients,conservative therapy may be appropriate.

  5. Lagarto gigante de La Gomera. Un fósil que vuelve a la vida

    OpenAIRE

    2000-01-01

    La única población conocida cuenta con sólo seis ejemplares. El lagarto gigante de La Gomera se encuentra en una situación bastante más grave que otros vertebrados europeos en peligro de extinción como el lince ibérico, la foca monje o el oso pardo.

  6. Spontaneous remission of acromegaly or gigantism due to subclinical apoplexy of pituitary growth hormone adenoma.

    Science.gov (United States)

    Wang, Xian-Ling; Dou, Jing-Tao; Lü, Zhao-Hui; Zhong, Wen-Wen; Ba, Jian-Ming; Jin, Du; Lu, Ju-Ming; Pan, Chang-Yu; Mu, Yi-Ming

    2011-11-01

    Subclinical apoplexy of pituitary functional adenoma can cause spontaneous remission of hormone hypersecretion. The typical presence of pituitary growth hormone (GH) adenoma is gigantism and/or acromegaly. We investigated the clinical characteristics of patients with spontaneous partial remission of acromegaly or gigantism due to subclinical apoplexy of GH adenoma. Six patients with spontaneous remission of acromegaly or gigantism were enrolled. The clinical characteristics, endocrinological evaluation and imageological characteristics were retrospectively analyzed. In these cases, the initial clinical presences were diabetes mellitus or hypogonadism. No abrupt headache, vomiting, visual function impairment, or conscious disturbance had ever been complained of. The base levels of GH and insulin growth factor-1 (IGF-1) were normal or higher, but nadir GH levels were all still > 1 µg/L in 75 g oral glucose tolerance test. Magnetic resonance imaging detected enlarged sella, partial empty sella and compressed pituitary. The transsphenoidal surgery was performed in 2 cases, and the other patients were conservatively managed. All the patients were in clinical remission. When the clinical presences, endocrine evaluation, biochemical examination and imageology indicate spontaneous remission of GH hypersecretion in patients with gigantism or acromegaly, the diagnosis of subclinical apoplexy of pituitary GH adenoma should be presumed. To these patients, conservative therapy may be appropriate.

  7. Increased Population Risk of AIP-Related Acromegaly and Gigantism in Ireland.

    Science.gov (United States)

    Radian, Serban; Diekmann, Yoan; Gabrovska, Plamena; Holland, Brendan; Bradley, Lisa; Wallace, Helen; Stals, Karen; Bussell, Anna-Marie; McGurren, Karen; Cuesta, Martin; Ryan, Anthony W; Herincs, Maria; Hernández-Ramírez, Laura C; Holland, Aidan; Samuels, Jade; Aflorei, Elena Daniela; Barry, Sayka; Dénes, Judit; Pernicova, Ida; Stiles, Craig E; Trivellin, Giampaolo; McCloskey, Ronan; Ajzensztejn, Michal; Abid, Noina; Akker, Scott A; Mercado, Moises; Cohen, Mark; Thakker, Rajesh V; Baldeweg, Stephanie; Barkan, Ariel; Musat, Madalina; Levy, Miles; Orme, Stephen M; Unterländer, Martina; Burger, Joachim; Kumar, Ajith V; Ellard, Sian; McPartlin, Joseph; McManus, Ross; Linden, Gerard J; Atkinson, Brew; Balding, David J; Agha, Amar; Thompson, Chris J; Hunter, Steven J; Thomas, Mark G; Morrison, Patrick J; Korbonits, Márta

    2017-01-01

    The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304(*) (or p.R304(*) ; NM_003977.3:c.910C>T, p.Arg304Ter) identified in Northern Ireland (NI) predisposes to acromegaly/gigantism; its population health impact remains unexplored. We measured R304(*) carrier frequency in 936 Mid Ulster, 1,000 Greater Belfast (both in NI) and 2,094 Republic of Ireland (ROI) volunteers and in 116 NI or ROI acromegaly/gigantism patients. Carrier frequencies were 0.0064 in Mid Ulster (95%CI = 0.0027-0.013; P = 0.0005 vs. ROI), 0.001 in Greater Belfast (0.00011-0.0047) and zero in ROI (0-0.0014). R304(*) prevalence was elevated in acromegaly/gigantism patients in NI (11/87, 12.6%, P acromegaly/gigantism cases. tMRCA is consistent with historical/folklore accounts of Irish giants. Forward simulations predict many undetected carriers; geographically targeted population screening improves asymptomatic carrier identification, complementing clinical testing of patients/relatives. We generated disease awareness locally, necessary for early diagnosis and improved outcomes of AIP-related disease. © 2016 The Authors. **Human Mutation published by Wiley Periodicals, Inc.

  8. Quiste del colédoco como causa de dolor abdominal: revisión de un caso y bibliografía

    Directory of Open Access Journals (Sweden)

    Laura Arroyo Martínez

    2004-09-01

    Full Text Available El quiste del colédoco se define como la dilatación congénita o combinada del árbol biliar extrahepático (tipo más frecuente o intrahepático. La etiología no está aún determinada, pero existen tres teorías. Esta patología se observa en niños y adultos, predominantemente en mujeres. Pueden manifestarse anomalías en todo el sistema biliar, ya sea intra o extrahepático. Se clasifica en 5 tipos. Antes, el abordaje de dichos quistes era la cistoentero anastomosis, pero ahora se recomienda realizar una escisión completa del quiste, para disminuir el riesgo de malignidad y desarrollo de colangitis o pancreatitis recurrente. Aquí se presenta el caso de una mujer de 21 años con dolor abdominal, ictericia y una masa en el hipocondrío derecho, secundario a dicha patología, que fue sometida a una resección quirúrgica con anastomosis primaria. La evaluación anatomopatológica demostró una estructura quística de aspecto similar a una vesícula biliar, congestiva y pardusca, con inflamación crónica leve. Tuvo un postoperatorio satisfactorio y egresó con tratamiento antibiótico. El quiste coledociano debe considerarse en el diagnóstico diferencial de aquellos pacientes con dolor abdominal y masa en el cuadrante.Choledochal cyst is a dilatation of a component of the biliary tree and it may include both intra and extrahepatic sites. They are classified into five types, all of which are relatively rare. Previously, choledochal cysts were treated with biliaryenteric bypass procedures. The current recommendation is to attempt their complete excision to minimize the known risk of fecoming malignant and the development of recurrent cholangitis or pancreatitis that may occur in these patients. We present here the case of a 21 year old woman with abdominal pain and jaundice due to a type 1 choledochal cyst. The cyst was removed and patient did fine.

  9. Presentación clínica atípica de un quiste dentígero Atypical clinical presentation of a dentigerous cyst

    Directory of Open Access Journals (Sweden)

    Denia Morales Navarro

    2009-12-01

    Full Text Available Los quistes dentígeros suelen ser, en la mayor parte de los casos, un hallazgo casual; por lo general se descubren al investigar la no erupción de un diente permanente. Ocupan el segundo lugar en frecuencia de aparición en los maxilares después del quiste radicular. Cuando el seno maxilar es invadido por estos quistes los síntomas usualmente aparecen tardíos en el proceso. Estos pueden incluir dolor facial, parestesia como consecuencia de la presión sobre un nervio, dolor de cabeza, trismo, trastornos de la gustación y congestión nasal. Por lo infrecuente de la localización maxilar y la corta edad de la paciente nos vimos motivados a revisar lo más reciente de la bibliografía que aborda este tema y a presentar el caso clínico de una paciente femenina de 17 años que fue diagnosticada y tratada por presentar un quiste dentígero en dicha ubicación. Se enfatiza en la importancia del correcto diagnóstico y el establecimiento de una terapéutica concordante en cada caso.Dentigerous cysts are a casual finding in most of cases, in general discovered in investigation of a not eruption of permanent tooth. These occupy the second place in appearance frequency in maxillaries after radicular cyst. When maxillary sinus is invaded by these cysts, symptoms usually appear late in the process. These could include facial pain, paresthesia as consequence of pressure on nerve, headache, trismus, taste disorders and nasal congestion. Due the infrequent of the maxillary location and the short age of patient we reviewed the more recent of bibliography on this subject and to present the clinical case of other female patient aged 17 diagnosed with and treated by dentigerous cyst in such location, emphasizing on the significance of a appropriate diagnosis and establishment of a therapy in accord in each case

  10. Presentación de un caso de quiste dermoide con ubicación poco frecuente Presentation of a dermoid cyst case with an unusual location

    OpenAIRE

    A. Ostrosky; R. Luberti; E. Mareso; J. Klurfan Federico

    2005-01-01

    El quiste dermoide es una patología benigna de origen embrionario y su localización en el piso de la boca es poco frecuente. No presenta predilección por sexo y aparece, especialmente, entre la segunda y la tercera década de vida. Para su diagnóstico son útiles las tomografías computadas y las resonancias nucleares magnéticas. El tratamiento es quirúrgico. Tanto las recidivas como la transformación maligna son excepcionales.The Dermoid Cyst is a benign pathology of embrionary origin and its l...

  11. Impacto de la dieta sobre la inducción de infección con quistes de Giardia lamblia en ratas Sprague-Dawley

    OpenAIRE

    Díaz-Cinco Martha Elvia; Ballesteros-Vázquez Martha Nydia; Pérez-Morales Rosalba; Mata-Haro Verónica

    2002-01-01

    Objetivo. Evaluar el efecto de la desnutrición en la inducción de la giardiosis con diferentes concentraciones de quistes de Giardia lamblia utilizando como modelo animal ratas Sprague-Dawley. Material y métodos. Es un estudio experimental efectuado entre 1995 y 1999, en el Centro de Investigación en Alimentación y Desarrollo, de la ciudad de Hermosillo, estado de Sonora, México, y cuya muestra estuvo integrada por dos grupos de 6 a 8 unidades experimentales, las cuales recibieron dos tipos d...

  12. Modelización de la distribución espacial de quistes en el estómago de la marsopa mediante un proceso de Gibbs

    OpenAIRE

    Mateu, Jorge; Montes, F.

    1998-01-01

    En un trabajo previo (Balaguer et al., 1992) los autores estudiaron la distribución espacial de los quistes en el estómago de la marsopa para contrastar su compatibilidad con la hipótesis de aleatoriedad espacial completa (AEC). El resultado condujo a rechazar la hipótesis señalando en la dirección de un patrón agregado, confirmando la sospecha inicial de los zoólogos. Este trabajo completa aquel estudio en la dirección que parece más coherente a sus autores: la de conjeturar un modelo pun...

  13. Correlación anatomopatológica entre la biopsia preoperatoria y la pieza quirúrgica de quistes dentigeros y queratoquistes odontogenicos

    OpenAIRE

    Mordcovich Maldonado, Gonzalo

    2014-01-01

    En este estudio se analizó la correlación entre las biopsias preoperatoria y posoperatoria de 15 pacientestratados con quistes dentígeros (QD) y 15 pacientes tratados con queratoquistes (QQ). De esta manera se comparó cual de las dos patologías es más propensa a presentar transformaciones histopatológicas, su relación con el sexo, la edad, el mayor número de recidivas y la localización anatómica más frecuente Objetivo: se realizó el estudio de las biopsias preoperatorias (biopsia por imcisión...

  14. The early ELF signals of the gigantic jets captured by the Taiwan ground observation network

    Science.gov (United States)

    Chen, A. B. C.; Huang, P. H.; Su, H. T.; Hsu, R. R.

    2015-12-01

    The in-cloud ignition process of gigantic jets and blue jets receives attentions and discussions in the past years. The polarity and the position of their breakdown were proposed by Krehbiel et al. [2008] but no concrete observational evidence to support it directly. ELF spectrogram is a good tool to explore the electric activities, but traditional spectrograms are generated by a Fourier transform which obtain the frequency information through an integration operation. However the integration greatly limits the lowest frequency revealed by spectrogram and buries the important transient features. In this study, we applied a new but widely-used method, the Hilbert-Huang transform (HHT), to explore the spectrogram. Instead of the integration, HHT obtains the frequency information by differentiating on the phase angle, and become a powerful tool to reveal the fast frequency variation associated with transient luminous events. More than 100 transient luminous events including 25 gigantic jets observed by Taiwan ground optical observation network were analyzed. The results indicate that approximately 70% of gigantic jets can identify a rapid frequency variation in the interval of 300-600 milliseconds before main surge discharge, and this early feature can not find a clear corresponding amplitude variation in its sferic. Since this early signal can not be identified from the traditional Fourier spectrogram, but clear in-cloud lightning was registered correspondingly by the ground optical observation. In contrast to gigantic jets, this feature of early frequency change can be seen only in less than 30% of sprites and elves. These observational evidences are able to provide new constraints on the early discharge process of gigantic jets in clouds.

  15. Impacto de la dieta sobre la inducción de infección con quistes de Giardia lamblia en ratas Sprague-Dawley The effect of malnourishment on the development of giardiosis in Sprague-Dawley rats

    National Research Council Canada - National Science Library

    Martha Elvia Díaz-Cinco; Martha Nydia Ballesteros-Vázquez; Rosalba Pérez-Morales; Verónica Mata-Haro

    2002-01-01

    Objetivo. Evaluar el efecto de la desnutrición en la inducción de la giardiosis con diferentes concentraciones de quistes de Giardia lamblia utilizando como modelo animal ratas Sprague-Dawley. Material y métodos...

  16. Quiste óseo simple: Reporte de un caso y revisión de la literatura Simple bone cyst: a case report and a literature review

    Directory of Open Access Journals (Sweden)

    B.R. Chrcanovic

    2011-08-01

    Full Text Available El quiste óseo simple, es una cavidad intraósea sin recubrimiento epitelial, siendo considerado un pseudoquiste. Clínicamente, la lesión suele ser asintomática y descubierta por casualidad en un examen radiológico de rutina. Su etiología y patogenia no están aún definitivamente establecidas. El tratamiento tradicional consiste en realizar una exploración quirúrgica y curetaje de la pared ósea. En este artículo se presenta un caso de quiste óseo simple localizado en la sínfisis mandibular, de dimensión mediana, que acomete a un paciente de sexo masculino de 14 años de edad, revelando datos clínicos, aspectos diagnósticos, imagenológicos, así como su tratamiento.The simple bony cyst is an intraosseous cavity without epithelial lining, being considered a pseudocyst. Clinically, the lesion is usually asymptomatic and discovered by accident in a routine radiological examination. Its etiology and patogenesis are not yet definitely established. The traditional treatment consists of realizing a surgical exploration and curettage of the bony wall. This article presents a case of simple bony cyst located in the mandibular symphysis, of median dimension of a masculine patient of 14 years of age, describing clinical, diagnostic aspect, imaging, as well as the treatment.

  17. A gigantic nothosaur (Reptilia: Sauropterygia) from the Middle Triassic of SW China and its implication for the Triassic biotic recovery

    Science.gov (United States)

    Liu, Jun; Hu, Shi-Xue; Rieppel, Olivier; Jiang, Da-Yong; Benton, Michael J.; Kelley, Neil P.; Aitchison, Jonathan C.; Zhou, Chang-Yong; Wen, Wen; Huang, Jin-Yuan; Xie, Tao; Lv, Tao

    2014-11-01

    The presence of gigantic apex predators in the eastern Panthalassic and western Tethyan oceans suggests that complex ecosystems in the sea had become re-established in these regions at least by the early Middle Triassic, after the Permian-Triassic mass extinction (PTME). However, it is not clear whether oceanic ecosystem recovery from the PTME was globally synchronous because of the apparent lack of such predators in the eastern Tethyan/western Panthalassic region prior to the Late Triassic. Here we report a gigantic nothosaur from the lower Middle Triassic of Luoping in southwest China (eastern Tethyan ocean), which possesses the largest known lower jaw among Triassic sauropterygians. Phylogenetic analysis suggests parallel evolution of gigantism in Triassic sauropterygians. Discovery of this gigantic apex predator, together with associated diverse marine reptiles and the complex food web, indicates global recovery of shallow marine ecosystems from PTME by the early Middle Triassic.

  18. Efficacy, safety, and pharmacokinetics of sustained-release lanreotide (lanreotide Autogel) in Japanese patients with acromegaly or pituitary gigantism.

    Science.gov (United States)

    Shimatsu, Akira; Teramoto, Akira; Hizuka, Naomi; Kitai, Kazuo; Ramis, Joaquim; Chihara, Kazuo

    2013-01-01

    The somatostatin analog lanreotide Autogel has proven to be efficacious for treating acromegaly in international studies and in clinical practices around the world. However, its efficacy in Japanese patients has not been extensively evaluated. We examined the dose-response relationship and long-term efficacy and safety in Japanese patients with acromegaly or pituitary gigantism. In an open-label, parallel-group, dose-response study, 32 patients (29 with acromegaly, 3 with pituitary gigantism) received 5 injections of 60, 90, or 120 mg of lanreotide Autogel over 24 weeks. Four weeks after the first injection, 41% of patients achieved serum GH level of gigantism) received lanreotide Autogel once every 4 weeks for a total of 13 injections. Dosing was initiated with 90 mg and adjusted according to clinical responses at Weeks 16 and/or 32. At Week 52, 47% of patients had serum GH levels of gigantism.

  19. Efficacy, safety, and pharmacokinetics of sustained-release lanreotide (lanreotide Autogel) in Japanese patients with acromegaly or pituitary gigantism

    National Research Council Canada - National Science Library

    Akira Shimatsu; Akira Teramoto; Naomi Hizuka; Kazuo Kitai; Joaquim Ramis; Kazuo Chihara

    2013-01-01

    .... However, its efficacy in Japanese patients has not been extensively evaluated. We examined the dose-response relationship and long-term efficacy and safety in Japanese patients with acromegaly or pituitary gigantism...

  20. Gigantic Cosmic Corkscrew Reveals New Details About Mysterious Microquasar

    Science.gov (United States)

    2004-10-01

    Making an extra effort to image a faint, gigantic corkscrew traced by fast protons and electrons shot out from a mysterious microquasar paid off for a pair of astrophysicists who gained new insights into the beast's inner workings and also resolved a longstanding dispute over the object's distance. Microquasar SS 433 VLA Image of Microquasar SS 433 CREDIT: Blundell & Bowler, NRAO/AUI/NSF (Click on Image for Larger Version) The astrophysicists used the National Science Foundation's Very Large Array (VLA) radio telescope to capture the faintest details yet seen in the plasma jets emerging from the microquasar SS 433, an object once dubbed the "enigma of the century." As a result, they have changed scientists' understanding of the jets and settled the controversy over its distance "beyond all reasonable doubt," they said. SS 433 is a neutron star or black hole orbited by a "normal" companion star. The powerful gravity of the neutron star or black hole draws material from the stellar wind of its companion into an accretion disk of material tightly circling the dense central object prior to being pulled onto it. This disk propels jets of fast protons and electrons outward from its poles at about a quarter of the speed of light. The disk in SS 433 wobbles like a child's top, causing its jets to trace a corkscrew in the sky every 162 days. The new VLA study indicates that the speed of the ejected particles varies over time, contrary to the traditional model for SS 433. "We found that the actual speed varies between 24 percent to 28 percent of light speed, as opposed to staying constant," said Katherine Blundell, of the University of Oxford in the United Kingdom. "Amazingly, the jets going in both directions change their speeds simultaneously, producing identical speeds in both directions at any given time," Blundell added. Blundell worked with Michael Bowler, also of Oxford. The scientists' findings have been accepted by the Astrophysical Journal Letters. SS 433 New VLA

  1. [A multicenter clinical trial of SMS 201-995 (octreotide acetate) in acromegaly and gigantism].

    Science.gov (United States)

    Shimatsu, A; Imura, H; Irie, M; Nakagawa, S; Goto, Y; Shimizu, N; Takeda, R; Kato, Y; Saito, S; Ibayashi, H

    1989-07-20

    Sixty-four patients with active acromegaly and three patients with gigantism were treated with the long acting somatostatin analog SMS 201-995 (50-500 micrograms, sc, every 6-12 h or 150-880 micrograms daily by intermittent sc infusion, for up to 114 weeks). The fasting plasma GH levels were significantly suppressed (less than 50% of the values before treatment) in 49 patients and became normal in 18 patients. Suppression of GH secretion was associated with normalization of plasma somatomedin-C levels (14 out of 30 cases) and significant clinical improvement such as disappearance of headache and decrease of excessive sweating. Shrinkage of pituitary tumors as determined by computed tomography and/or magnetic resonance imaging studies occurred in 11 out of 40 cases. Side effects were minimal and tolerable. SMS 201-995 appears to be an effective agent for the treatment of acromegaly and gigantism.

  2. The acromegaly--gigantism syndrome. Report of four cases treated surgically.

    Science.gov (United States)

    Zampieri, P; Scanarini, M; Sicolo, N; Andrioli, G; Mingrino, S

    1983-12-01

    Four cases of growth-hormone-secreting pituitary adenoma, with associated aspects of acromegaly and gigantism, are reported in patients aged 12-26. All of the patients had macroadenomas and were treated surgically, three by the transsphenoidal approach and one with a transfrontal craniotomy. Histologic examination revealed eosinophilic adenomas in three of the cases and a mixed eosinophilic--chromophobe adenoma in one, all with cellular irregularities (mitosis and cellular and nuclear polymorphism), local invasivity, or both. Because surgical treatment did not produce complete normalization of growth hormone levels, radiotherapy followed the operations in all four cases. In our opinion, the treatment of acromegalic gigantism poses more therapeutic problems than that of simple acromegaly, with combined treatment (surgical, radiation, and medical) often being necessary.

  3. Cuantificación de factores de riesgo para mastitis, quistes ováricos, hipocalcemia y cetosis usando regresión logística en ganado Holstein Quantification of risk factors for mastitis, ovarian cyst, milk fever and ketosis (in Holstein cattle) using logistic regression in Holstein cattle

    National Research Council Canada - National Science Library

    H. A. URIBE

    1998-01-01

    ... producción tienen mayores demandas en mano de obra y una mayor frecuencia de enfermedades. El objetivo de este trabajo fue cuantificar algunos de los factores de riesgo en la incidencia de mastitis, quistes...

  4. Unilateral delayed opercularization in a case of Sotos' syndrome (cerebral gigantism)

    Energy Technology Data Exchange (ETDEWEB)

    Barth, P.G.; Vlasveld, L.; Valk, J.

    1980-08-01

    A case of Sotos' syndrome (cerebral gigantism) is described. Pneumencephalography, performed at the age of 15 days, revealed abnormal separation of the opercula on the right. By comparing the contours with developmental anatomical features of this area it agreed with a foetal development of 24 weeks gestational age. Bilateral carotid angiography was normal. CT showed normal development of the Sylvian area at the age of 27 months.

  5. EL ERYNGIUM ("CARDO" GIGANTE DEL DELTA DEL PARANA Y DE LA MESOPOTAMIA ARGENTINA

    Directory of Open Access Journals (Sweden)

    Troels Myndel Pedersen

    2010-11-01

    Full Text Available Un Eryngium gigante, espectacular por su tamaño y la abundancia donde se presenta, muy común a lo largo de la Mesopotamia argentina, el delta del Río Paraná, y la orilla sur del Río de la Plata, cuya identidad ha sido interpretada de diversas maneras, se describe como una nueva especie, Eryngium mesopotamicum Pedersen

  6. Mixoma gigante de átrio esquerdo Giant left atrial myxoma

    Directory of Open Access Journals (Sweden)

    Juan Francisco Muñoz Cruz

    1998-11-01

    Full Text Available Homem de 65 anos, portador de miocardiopatia dilatada e hipertensão arterial de longa data, com antecedentes de acidente vascular cerebral e que, ao ecocardiograma, apresentou mixoma gigante de átrio esquerdo.A 65 year-old man with dilated cardiomiopathy and long history of high blood pressure and a previous cerebral vascular accident had a giant left atrial myxoma as an echocardiographic finding.

  7. Increased Population Risk of AIP‐Related Acromegaly and Gigantism in Ireland

    Science.gov (United States)

    Radian, Serban; Diekmann, Yoan; Gabrovska, Plamena; Holland, Brendan; Bradley, Lisa; Wallace, Helen; Stals, Karen; Bussell, Anna‐Marie; McGurren, Karen; Cuesta, Martin; Ryan, Anthony W.; Herincs, Maria; Hernández‐Ramírez, Laura C.; Holland, Aidan; Samuels, Jade; Aflorei, Elena Daniela; Barry, Sayka; Dénes, Judit; Pernicova, Ida; Stiles, Craig E.; Trivellin, Giampaolo; McCloskey, Ronan; Ajzensztejn, Michal; Abid, Noina; Akker, Scott A.; Mercado, Moises; Cohen, Mark; Thakker, Rajesh V.; Baldeweg, Stephanie; Barkan, Ariel; Musat, Madalina; Levy, Miles; Orme, Stephen M.; Unterländer, Martina; Burger, Joachim; Kumar, Ajith V.; Ellard, Sian; McPartlin, Joseph; McManus, Ross; Linden, Gerard J.; Atkinson, Brew; Balding, David J.; Agha, Amar; Thompson, Chris J.; Hunter, Steven J.; Thomas, Mark G.; Morrison, Patrick J.

    2016-01-01

    ABSTRACT The aryl hydrocarbon receptor interacting protein (AIP) founder mutation R304* (or p.R304*; NM_003977.3:c.910C>T, p.Arg304Ter) identified in Northern Ireland (NI) predisposes to acromegaly/gigantism; its population health impact remains unexplored. We measured R304* carrier frequency in 936 Mid Ulster, 1,000 Greater Belfast (both in NI) and 2,094 Republic of Ireland (ROI) volunteers and in 116 NI or ROI acromegaly/gigantism patients. Carrier frequencies were 0.0064 in Mid Ulster (95%CI = 0.0027–0.013; P = 0.0005 vs. ROI), 0.001 in Greater Belfast (0.00011–0.0047) and zero in ROI (0–0.0014). R304* prevalence was elevated in acromegaly/gigantism patients in NI (11/87, 12.6%, P < 0.05), but not in ROI (2/29, 6.8%) versus non‐Irish patients (0–2.41%). Haploblock conservation supported a common ancestor for all the 18 identified Irish pedigrees (81 carriers, 30 affected). Time to most recent common ancestor (tMRCA) was 2550 (1,275–5,000) years. tMRCA‐based simulations predicted 432 (90–5,175) current carriers, including 86 affected (18–1,035) for 20% penetrance. In conclusion, R304* is frequent in Mid Ulster, resulting in numerous acromegaly/gigantism cases. tMRCA is consistent with historical/folklore accounts of Irish giants. Forward simulations predict many undetected carriers; geographically targeted population screening improves asymptomatic carrier identification, complementing clinical testing of patients/relatives. We generated disease awareness locally, necessary for early diagnosis and improved outcomes of AIP‐related disease. PMID:27650164

  8. Cerebral gigantism associated with jaw cyst basal cell naevoid syndrome in two families.

    Science.gov (United States)

    Cramer, H; Niederdellmann, H

    1983-01-01

    We report 9 subjects from 2 families with the syndrome of cerebral gigantism, seven of the patients also had jaw cyst basal cell naevoid syndrome. Neurological, radiological, somatic and biochemical features of this hitherto unreported association are described. Neurological symptoms included mild hydrocephalus, ventricular malformation, cerebellar syndrome, intracranial calcification, oculomotor disturbances, EEG abnormalities and rarely, mild peripheral nervous disorders. A disturbance of calcium metabolism appears to be a prominent feature of the genetically determined nonprogressive syndrome.

  9. Starvation reveals the cause of infection-induced castration and gigantism.

    Science.gov (United States)

    Cressler, Clayton E; Nelson, William A; Day, Troy; McCauley, Edward

    2014-10-01

    Parasites often induce life-history changes in their hosts. In many cases, these infection-induced life-history changes are driven by changes in the pattern of energy allocation and utilization within the host. Because these processes will affect both host and parasite fitness, it can be challenging to determine who benefits from them. Determining the causes and consequences of infection-induced life-history changes requires the ability to experimentally manipulate life history and a framework for connecting life history to host and parasite fitness. Here, we combine a novel starvation manipulation with energy budget models to provide new insights into castration and gigantism in the Daphnia magna-Pasteuria ramosa host-parasite system. Our results show that starvation primarily affects investment in reproduction, and increasing starvation stress reduces gigantism and parasite fitness without affecting castration. These results are consistent with an energetic structure where the parasite uses growth energy as a resource. This finding gives us new understanding of the role of castration and gigantism in this system, and how life-history variation will affect infection outcome and epidemiological dynamics. The approach of combining targeted life-history manipulations with energy budget models can be adapted to understand life-history changes in other disease systems.

  10. The triangulation of the gigantic jets observed by the optical observation network in Taiwan

    Science.gov (United States)

    Chen, Alfred B.; Huang, Chien-Fong; Peng, Kang-Ming; Su, Han-Tzong; Hsu, Rue-Ron

    2015-04-01

    The optical triangulation of sprites and elves by the multiple sites has been done in the past decades, but the similar observation on gigantic jets has never been reported yet. A ground optical observation network consisting of four stations at Kimen, Penghu, Tainan, and Taitung (from west to east) has been established in Taiwan since 2012. Each station equipped with two sets of Watec low-light sensitivity cameras, and the elevation and azimuth of the observation can be fully remote controlled to point toward the on-going convection system in the vicinity of Taiwan. In summer 2014, more than 6 gigantic jets were captured by at least two stations successfully. The triangulation and ULF sferics of these interesting events provides an excellent chance to explore the spatial and temporal evolution of the jets in different phases. In this presentation, this ground observation network will be introduced, the detail evolution of the recorded gigantic jets is presented. The preliminary result implies that the jets may not pop from the cloudtop straightforwardly, and some twists occur during the propagation of the jets. A more complicated analysis of the tomography for the advanced triangulation will be mentioned, too.

  11. Ecological explanations to island gigantism: dietary niche divergence, predation, and size in an endemic lizard.

    Science.gov (United States)

    Runemark, Anna; Sagonas, Kostas; Svensson, Erik I

    2015-08-01

    Although rapid evolution of body size on islands has long been known, the ecological mechanisms behind this island phenomenon remain poorly understood. Diet is an important selective pressure for morphological divergence. Here we investigate if selection for novel diets has contributed to the multiple independent cases of island gigantism in the Skyros wall lizard (Podarcis gaigeae) and if diet, predation, or both factors best explain island gigantism. We combined data on body size, shape, bite force, and realized and available diets to address this. Several lines of evidence suggest that diet has contributed to the island gigantism. The larger islet lizards have relatively wider heads and higher bite performance in relation to mainland lizards than would be expected from size differences alone. The proportions of consumed and available hard prey are higher on islets than mainland localities, and lizard body size is significantly correlated with the proportion of hard prey. Furthermore, the main axis of divergence in head shape is significantly correlated with dietary divergence. Finally, a model with only diet and one including diet and predation regime explain body size divergence equally well. Our results suggest that diet is an important ecological factor behind insular body size divergence, but could be consistent with an additional role for predation.

  12. Trombo mural gigante como causa de cardioembolismo: Presentación de un caso Gigantic mural thrombus causing thromboembolism: Report of one case

    Directory of Open Access Journals (Sweden)

    Alberto Barón C

    2009-12-01

    Full Text Available Se presenta el caso de un hombre de setenta y un años de edad quien presenta en forma súbita síntomas y signos isquémicos cerebrales. Tiene antecedente de fibrilación auricular crónica, prótesis valvular en posición aórtica y mitral, insuficiencia cardiaca y complicaciones hemorrágicas relacionadas con la anticoagulación. Como parte del estudio se realizó ecocardiograma transesofágico que demostró trombo mural gigante en la aurícula izquierda, el cual desapareció luego de nueve meses de tratamiento anticoagulante.The case of a 71 years old male that suddenly presents ischemic brain signs and symptoms is presented. He had a previous history of chronic atrial fibrillation, mitral and aortic valve protheses, heart failure and bleeding related to anticoagulation. A transesophageal echocardiogram was performed as part of the assessment, showing a gigantic left atrial mural thrombus that disappeared after 9 months of anticoagulation therapy.

  13. Colloidal cyst of the third ventricle. Case presentation Quiste coloide del tercer ventrículo. Presentación de un caso

    Directory of Open Access Journals (Sweden)

    Joan O Rojas Fuentes

    2009-09-01

    Full Text Available

    Colloidal cysts are congenital intracranial benign lesions of the anterior superior portion of the third ventricle. They represent between the 0,2 and 2 % of all the intracranial tumours and represent the 15 or 20 % of all the intraventricular masses. They become symptomatic during the adolescence or early adulthood and start normally with migraine or symptoms of intracranial hypertension causing obstructive hydrocephaly. We present the case of a teenager of 18 years of age with history of migraine after two years and the symptoms worsened in intensity and frequency including vomiting and bilateral paresthesia; the diagnosis was obstructive hydrocephaly with colloidal cyst of the third ventricle. An appropriate practice was adopted due to the uncertain diagnosis in order to avoid neurological damage and death. We discussed the main characteristics of the colloidal cyst, its clinical presentation and radiological characteristics and we performed.

    Los quistes coloides son lesiones intracraneales congénitas benignas, de la porción antero-superior del tercer ventrículo. Suponen del 0,2 al 2 % de todos los tumores intracraneales y representan del 15 al 20 % de todas las masas intraventriculares. Comienzan a ser sintomáticos en la adolescencia o edad adulta temprana, generalmente con manifestaciones de cefalea o síntomas de hipertensión intracraneal al provocar hidrocefalia obstructiva. Se presenta una adolescente de 18 años con historia de cefalea de 2 años de evolución, cuyos síntomas fueron empeorando en intensidad y frecuencia, acompañados de vómitos y parestesias bilaterales; se le diagnosticó hidrocefalia obstructiva con quiste coloide del tercer ventrículo. Ante la sospecha del diagnóstico se tomó una conducta adecuada, para evitar el deterioro neurológico y la muerte. Se discutieron las principales características del quiste coloide, su cuadro clínico y radiológico.

  14. Presentación de un caso de quiste dermoide con ubicación poco frecuente Presentation of a dermoid cyst case with an unusual location

    Directory of Open Access Journals (Sweden)

    A. Ostrosky

    2005-02-01

    Full Text Available El quiste dermoide es una patología benigna de origen embrionario y su localización en el piso de la boca es poco frecuente. No presenta predilección por sexo y aparece, especialmente, entre la segunda y la tercera década de vida. Para su diagnóstico son útiles las tomografías computadas y las resonancias nucleares magnéticas. El tratamiento es quirúrgico. Tanto las recidivas como la transformación maligna son excepcionales.The Dermoid Cyst is a benign pathology of embrionary origin and its localization in the floor of the mouth is not very frequent. With no preference for sex, it appears especially between the second and third decades of life. Computed scans and magnetic nuclear reso-nances are useful for its diagnosis. The treatment is surgical and recurrences, as well as malignant transformation, are exceptional.

  15. Investigación experimental de la equinococosis canina a partir de quiste hidatídico de origen porcino en México

    OpenAIRE

    1999-01-01

    OBJETIVO: Para evaluar la infección y obtener el estado adulto del cestodos, se buscó reproducir la equinococosis en perros a partir de quiste hidatídico de origen porcino. MÉTODOS: Se formaron 2 grupos, uno de 5 y otro de 3 perros, a cada animal del grupo experimental se le dió 2 g de membrana germinativa de quíste hidatídico fértil por vía oral, el segundo grupo fue testigo. Ambos grupos fueron evaluados clínica, serológica y parasitológicamente, en el grupo experimental se sacrificó un ani...

  16. Estructura del quiste hidatídico producido por Echinococcus oligarthrus en el hospedero intermediario Proechimys c.f. guairae (rata espinosa en Casanare, Colombia

    Directory of Open Access Journals (Sweden)

    Gerzain Rodríguez

    2000-09-01

    Full Text Available La equinococosis es un parasitismo grave producido en el hombre y en los animales por larvas de tenias del género Echinococcus que se desarrollan en el higado, el pulmón, el bazo y en otras visceras y tejidos. De las cuatro tenias dei género Echinococcus, tres se presentan en Suramerica: E granulosus, E. vogeli y E. oligarihrus. En Colombia se han informado casos en humanos y en animales cuyo agente etiológico más frecuente es E. vogeli. En este trabajo presentamos la estructura macroscópica, microscópica y de microscopia electrónica de barrido de quistes hidatídicos múltiples y de sus protoescólices encontrados en un Proechimys c.f guairae o rata espinosa, capturado en la vereda La Plata del municipio de Pore, Casanare, durante la búsqueda de reservorios del virus de la encefalitis equina venezolana. En la autopsia del animal se encontraron quistes múltiples en el higado, el bazo y el pulmón, la gran mayoría fértiles. Están constituidos por una pared franjeada que origina cápsulas proligeras dentro de las cuales están los protoescólices. El protoescólex es el escólex inmaduro del parásito adulto formado por cuatro ventosas y un rostelo con ganchos, cuyo tamaño y morfologia corresponden con las medidas de E. oligaiihrus. Ilustramos las caracteristicas morfológicas de las larvas, el desarrollo de los protoescólices y revisamos las caracteristicas de la equinococosis en Colombia.

  17. Reconstrucción de defectos óseos causados por quistes residuales de los maxilares con hidroxiapatita porosa coralina hap-200

    Directory of Open Access Journals (Sweden)

    Juan Carlos Quintana-Díaz

    2014-01-01

    Full Text Available Se presentan los resultados obtenidos como parte de la extensión de las aplicaciones clínicas de la Hidr oxiapatita Coralina ® HAP - 200 como biomaterial de implante para la regeneración del tejido óseo en la región maxilofacial. En este caso, se emplea en forma de gránulos para la restauración de defectos óseos causados por quistes residuales a 24 pacientes (17 2 quistes siguiendo las indicaciones y normas establecidas para el uso de este tipo de material. La evaluación clínica y radiográfica postoperatoria se realizó a los tres días, siete días, treinta días, tres meses, seis meses y al año de operados los paci entes, teniendo en cuenta la presencia e intensidad del dolor, eritema, edema, infección o exposición del biomaterial de implante según lo indicado en el protocolo de evaluación de estos productos. Los estudios clínicos y radiográficos longitudinales de lo s pacientes en el primer año después de implantados confirman los excelentes resultados en cuanto a la tolerancia y biocompatibilidad del producto, lográndose una excelente restauración estética. Como en estudios anteriores, en ningún caso se produjeron re acciones adversas al biomaterial. Los resultados confirman que la hidroxiapatita Coralina® HAP - 200 es un excelente biomaterial de sustitución ósea por su demostrada biocompatibilidad, osteointegración y no se reabsorbe apreciablemente en los primeros 12 me ses de implantado.

  18. Combined treatment with octreotide LAR and pegvisomant in patients with pituitary gigantism: clinical evaluation and genetic screening.

    Science.gov (United States)

    Mangupli, Ruth; Rostomyan, Liliya; Castermans, Emilie; Caberg, Jean-Hubert; Camperos, Paul; Krivoy, Jaime; Cuauro, Elvia; Bours, Vincent; Daly, Adrian F; Beckers, Albert

    2016-10-01

    Pituitary gigantism is a rare condition caused by growth hormone secreting hypersecretion, usually by a pituitary tumor. Acromegaly and gigantism cases that have a genetic cause are challenging to treat, due to large tumor size and poor responses to some medical therapies (e.g. AIP mutation affected cases and those with X-linked acrogigantism syndrome). We performed a retrospective study to identify gigantism cases among 160 somatotropinoma patients treated between 1985 and 2015 at the University Hospital of Caracas, Venezuela. We studied clinical details at diagnosis, hormonal responses to therapy and undertook targeted genetic testing. Among the 160 cases, eight patients (six males; 75 %) were diagnosed with pituitary gigantism and underwent genetic analysis that included array comparative genome hybridization for Xq26.3 duplications. All patients had GH secreting pituitary macroadenomas that were difficult to control with conventional treatment options, such as surgery or primary somatostatin receptor ligand (SRL) therapy. Combined therapy (long-acting SRL and pegvisomant) as primary treatment or after pituitary surgery and radiotherapy permitted the normalization of IGF-1 levels and clinical improvement. Novel AIP mutations were the found in three patients. None of the patients had Xq26.3 microduplications. Treatment of pituitary gigantism is frequently challenging; delayed control increases the harmful effects of GH excess, such as, excessive stature and symptom burden, so early diagnosis and effective treatment are particularly important in these cases.

  19. Current Opinion in Endocrinology, Diabetes, and Obesity “Pituitary gigantism: Update on Molecular Biology and Management”

    Science.gov (United States)

    Lodish, Maya B.; Trivellin, Giampaolo; Stratakis, Constantine A.

    2016-01-01

    Purpose of review To provide an update on the mechanisms leading to pituitary gigantism, as well as to familiarize the practitioner with the implication of these genetic findings on treatment decisions. Recent findings Prior studies have identified gigantism as a feature of a number of monogenic disorders, including mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene, multiple endocrine neoplasia types 1 and 4, McCune Albright Syndrome, Carney Complex, and the paraganglioma, pheochromocytoma and pituitary adenoma association (3PA) due to succinate dehydrogenase defects. We recently described a previously uncharacterized form of early-onset pediatric gigantism caused by microduplications on chromosome Xq26.3 and we termed it X-LAG (X-linked acrogigantism). The age of onset of increased growth in X-LAG is significantly younger than other pituitary gigantism cases, and control of growth hormone excess is particularly challenging. Summary Knowledge of the molecular defects that underlie pituitary tumorigenesis is crucial for patient care as they guide early intervention, screening for associated conditions, genetic counseling, surgical approach (partial or total hypophysectomy), and choice of medical management. Recently described microduplications of Xq26.3 account for more than 80% of the cases of early-onset pediatric gigantism. Early recognition of X-LAG may improve outcomes, as successful control of growth hormone excess requires extensive anterior pituitary resection and are difficult to manage with medical therapy alone. PMID:26574647

  20. Clinical and genetic characterization of pituitary gigantism: an international collaborative study in 208 patients.

    Science.gov (United States)

    Rostomyan, Liliya; Daly, Adrian F; Petrossians, Patrick; Nachev, Emil; Lila, Anurag R; Lecoq, Anne-Lise; Lecumberri, Beatriz; Trivellin, Giampaolo; Salvatori, Roberto; Moraitis, Andreas G; Holdaway, Ian; Kranenburg-van Klaveren, Dianne J; Chiara Zatelli, Maria; Palacios, Nuria; Nozieres, Cecile; Zacharin, Margaret; Ebeling, Tapani; Ojaniemi, Marja; Rozhinskaya, Liudmila; Verrua, Elisa; Jaffrain-Rea, Marie-Lise; Filipponi, Silvia; Gusakova, Daria; Pronin, Vyacheslav; Bertherat, Jerome; Belaya, Zhanna; Ilovayskaya, Irena; Sahnoun-Fathallah, Mona; Sievers, Caroline; Stalla, Gunter K; Castermans, Emilie; Caberg, Jean-Hubert; Sorkina, Ekaterina; Auriemma, Renata Simona; Mittal, Sachin; Kareva, Maria; Lysy, Philippe A; Emy, Philippe; De Menis, Ernesto; Choong, Catherine S; Mantovani, Giovanna; Bours, Vincent; De Herder, Wouter; Brue, Thierry; Barlier, Anne; Neggers, Sebastian J C M M; Zacharieva, Sabina; Chanson, Philippe; Shah, Nalini Samir; Stratakis, Constantine A; Naves, Luciana A; Beckers, Albert

    2015-10-01

    Despite being a classical growth disorder, pituitary gigantism has not been studied previously in a standardized way. We performed a retrospective, multicenter, international study to characterize a large series of pituitary gigantism patients. We included 208 patients (163 males; 78.4%) with growth hormone excess and a current/previous abnormal growth velocity for age or final height >2 s.d. above country normal means. The median onset of rapid growth was 13 years and occurred significantly earlier in females than in males; pituitary adenomas were diagnosed earlier in females than males (15.8 vs 21.5 years respectively). Adenomas were ≥10 mm (i.e., macroadenomas) in 84%, of which extrasellar extension occurred in 77% and invasion in 54%. GH/IGF1 control was achieved in 39% during long-term follow-up. Final height was greater in younger onset patients, with larger tumors and higher GH levels. Later disease control was associated with a greater difference from mid-parental height (r=0.23, P=0.02). AIP mutations occurred in 29%; microduplication at Xq26.3 - X-linked acrogigantism (X-LAG) - occurred in two familial isolated pituitary adenoma kindreds and in ten sporadic patients. Tumor size was not different in X-LAG, AIP mutated and genetically negative patient groups. AIP-mutated and X-LAG patients were significantly younger at onset and diagnosis, but disease control was worse in genetically negative cases. Pituitary gigantism patients are characterized by male predominance and large tumors that are difficult to control. Treatment delay increases final height and symptom burden. AIP mutations and X-LAG explain many cases, but no genetic etiology is seen in >50% of cases.

  1. Velocidades radiales de estrellas gigantes rojas y blue stragglers en cúmulos abiertos

    Science.gov (United States)

    González, J. F.; Lapasset, E.

    Se presentan mediciones de las estrellas más brillantes en los campos de los cúmulos abiertos NGC 6530, NGC 2516, NGC 3114, Cr 223 y NGC 2437. Mediante correlaciones cruzadas se obtiene la velocidad de unas 25 gigantes rojas con el objeto de derivar la velocidad media de cada asociación. En base a los espectros obtenidos de los blue stragglers se discuten sus principales características y su probabilidad de pertenencia. Finalmente, se presentan las observaciones para cinco nuevas binarias espectroscópicas detectadas.

  2. Neonatal repair of left atrial diverticulum with gigantic thrombus without cardiopulmonary bypass.

    Science.gov (United States)

    Higashida, Akihiko; Hoashi, Takaya; Sakaguchi, Heima; Ichikawa, Hajime

    2017-04-08

    A 5-day-old neonate with coarctation of the aorta, hypoplastic aortic arch, large apical muscular ventricular septal defect, and patent ductus arteriosus developed pulmonary over-circulation and systemic hypoperfusion underwent bilateral pulmonary artery banding through median sternotomy as a part of hybrid stage I palliation. At operation, left atrial diverticulum with gigantic thrombus formation at the base of the left atrial appendage was incidentally detected by intraoperative direct echocardiography, and therefore, was successfully resected with the whole thrombus inside it without use of cardiopulmonary bypass. Histopathological finding was compatible with diverticulum. The patient was free from atrial arrhythmia and recurrent thrombus formation.

  3. Bariones y gravitones gigantes en el marco de la correspondencia AdS/CFT

    OpenAIRE

    Picos Sol, Marco Antonio

    2016-01-01

    Se construyen y analizan dos tipos de configuraciones que pueden construirse en el espacio dual a la teoría ABJM (en la dualidad AdS_4/CFT_3): gravitones gigantes y vértices bariónicos. Ambas configuraciones hacen uso de la posibilidad de enrrollar branas en ciclos topológicamente no triviales en el lado gravitatorio de la dualidad. Los vértices bariónicos están formados por branas enrrolladas atadas a cuerdas que se extienden hasta la frontera de AdS, y son vistos desde el lado gauge com...

  4. Miocarditis de células gigantes que simula un infarto agudo de miocardio

    Directory of Open Access Journals (Sweden)

    Andrea Zappi

    2009-01-01

    Full Text Available La miocarditis de células gigantes (MCG es una entidad rara, de causa desconocida, de probable etiología autoinmune. Puede presentarse como insuficiencia cardíaca refractaria, asociarse con arritmias ventriculares y en otras ocasiones simular un infarto agudo de miocardio. Su pronóstico con frecuencia es ominoso, salvo que se realicen tratamiento inmunosupresor o trasplante cardíaco, este último con elevada recurrencia.REV ARGENT CARDIOL 2009;77:60-62.

  5. Formación y evolución de planetas gigantes

    Science.gov (United States)

    Benvenuto, O. G.; Brunini, A.

    Presentamos el estado actual del trabajo que estamos realizando en el estudio de la formación de planetas gigantes. Detallamos los algoritmos numéricos necesarios para realizar este tipo de cálculo. Presentamos algunos resultados de la formación de objetos con masas de hasta una docena de veces la del planeta Júpiter, resaltando las principales caracteríticas. Finalmente detallamos los problemas que pensamos abordar en un futuro cercano en este tema de investigación.

  6. Vínculos observacionais para o processo-S em estrelas gigantes de Bário

    Science.gov (United States)

    Smiljanic, R. H. S.; Porto de Mello, G. F.; da Silva, L.

    2003-08-01

    Estrelas de bário são gigantes vermelhas de tipo GK que apresentam excessos atmosféricos dos elementos do processo-s. Tais excessos são esperados em estrelas na fase de pulsos térmicos do AGB (TP-AGB). As estrelas de bário são, no entanto, menos massivas e menos luminosas que as estrelas do AGB, assim, não poderiam ter se auto-enriquecido. Seu enriquecimento teria origem em uma estrela companheira, inicialmente mais massiva, que evolui pelo TP-AGB, se auto-enriquece com os elementos do processo-s e transfere material contaminado para a atmosfera da atual estrela de bário. A companheira evolui então para anã branca deixando de ser observada diretamente. As estrelas de bário são, portanto, úteis como testes observacionais para teorias de nucleossíntese pelo processo-s, convecção e perda de massa. Análises detalhadas de abundância com dados de alta qualidade para estes objetos são ainda escassas na literatura. Neste trabalho construímos modelos de atmosferas e, procedendo a uma análise diferencial, determinamos parâmetros atmosféricos e evolutivos de uma amostra de dez gigantes de bário e quatro normais. Determinamos seus padrões de abundância para Na, Mg, Al, Si, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Sr, Y, Zr, Ba, La, Ce, Nd, Sm, Eu e Gd, concluindo que algumas estrelas classificadas na literatura como gigantes de bário são na verdade gigantes normais. Comparamos dois padrões médios de abundância, para estrelas com grandes excessos e estrelas com excessos moderados, com modelos teóricos de enriquecimento pelo processo-s. Os dois grupos de estrelas são ajustados pelos mesmos parâmetros de exposição de nêutrons. Tal resultado sugere que a ocorrência do fenômeno de bário com diferentes intensidades não se deve a diferentes exposições de nêutrons. Discutimos ainda efeitos nucleossintéticos, ligados ao processo-s, sugeridos na literatura para os elementos Cu, Mn, V e Sc.

  7. Gigantic terahertz magnetochromism via electromagnons in hexaferrite magnet Ba$_2$Mg$_2$Fe$_{12}$O$_{22}$

    OpenAIRE

    Kida, N.; Kumakura, S.; Ishiwata, S.; Taguchi, Y.; Tokura, Y.

    2011-01-01

    Effects of temperature (6--225 K) and magnetic field (0--7 T) on the low-energy (1.2--5 meV) electrodynamics of the electromagnon, the magnetic resonance driven by the light electric field, have been investigated for a hexaferrite magnet Ba$_2$Mg$_2$Fe$_{12}$O$_{22}$ by using terahertz time-domain spectroscopy. We find the gigantic terahertz magnetochromism via electromagnons; the magnetochromic change, as defined by the difference of the absorption intensity with and without magnetic field, ...

  8. QUISTES DE MAXILARES Y MANDÍBULA: ALGUNAS CARACTERÍSTICAS CLÍNICAS Y CORRELACIÓN ENTRE EL DIAGNÓSTICO RADIOLÓGICO E HISTOPATOLÓGICO.

    Directory of Open Access Journals (Sweden)

    Rafael Delgado Fernández

    2008-01-01

    Full Text Available Se realizó un estudio retrospectivo en el Departamento de Patología Bucal de la Facultad de Estomatología de Ciudad de la Habana, desde el 2002 hasta el 2006; con el objetivo de identificar algunas características clínicas y la correlación entre el diagnóstico radiológico e histopatológico de los quistes del maxilar y de la mandíbula.A partir de las 1324 biopsias estomatológicas realizadas en el periodo, fueron seleccionas aleatoriamente 662, se procesaron algunas variables de interés y se calculó el coeficiente de correlación (, también la sensibilidad, especificidad, valor predictivo positivo y negativo de la radiología para diagnosticar quistes.Resultados: se encontró correlación de moderada a fuerte entre el diagnóstico radiológico e histopatológico de los quistes (=0.70; la sensibilidad del estudio radiológico fue de 82,2%, especificidad de 95.1%, con un valor predictivo positivo de 63.7% y negativo de 98.1%.De los 62 casos de quistes 50 (82.64% eran inflamatorios y de ellos el radicular apical tuvo el mayor registro con 35 casos; el sexo femenino fue el más afectado aunque no significativamente (p>0.05; se reportó mayor frecuencia entre la segunda y quinta década de la vida, siendo más notable en el grupo de 31-40 años (25.80%; en cuanto a la localización los maxilares abarcaron el 74.19% frente a los mandibulares (p<0.05.Se concluye que la correlación identificada da la medida de una orientación diagnóstica clínica de los quistes de maxilar y mandíbula bastante adecuada por parte de los estomatólogos generales y especialistas en cirugía maxilofacial.

  9. Are sick individuals weak competitors? Competitive ability of snails parasitized by a gigantism-inducing trematode.

    Science.gov (United States)

    Seppälä, Otto; Karvonen, Anssi; Kuosa, Marja; Haataja, Maarit; Jokela, Jukka

    2013-01-01

    Parasitized individuals are often expected to be poor competitors because they are weakened by infections. Many trematode species, however, although extensively exploiting their mollusc hosts, also induce gigantism (increased host size) by diverting host resources towards growth instead of reproduction. In such systems, alternatively to reduced competitive ability due to negative effects of parasitism on host performance, larger size could allow more efficient resource acquisition and thus increase the relative competitive ability of host individuals. We addressed this hypothesis by testing the effect of a trematode parasite Diplostomum pseudospathaceum on the competitive ability of its snail host Lymnaea stagnalis. We experimentally examined the growth of snails kept in pairs in relation to their infection status and intensity of resource competition (i.e. food availability). We found that parasitized snails grew faster and their reproduction was reduced compared to unparasitized individuals indicating parasite-induced gigantism. However, growth of the snails was faster when competing with parasitized individuals compared to unparasitized snails indicating reduced competitive ability due to parasitism. The latter effect, however, was relatively weak suggesting that the effects of the parasite on snail physiology may partly override each other in determining competitive ability.

  10. Pituitary gigantism presenting with depressive mood disorder and diabetic ketoacidosis in an Asian adolescent.

    Science.gov (United States)

    Kuo, Sheng-Fong; Chuang, Wen-Yu; Ng, Sohching; Chen, Chih-Hung; Chang, Chen-Nen; Chou, Chi-Hsiang; Weng, Wei-Chieh; Yeh, Chih-Hua; Lin, Jen-Der

    2013-01-01

    Hyperglycemia is seldom described in young patients with pituitary gigantism. Here, we describe the case of a 17-year-old Taiwanese boy who developed depressive mood disorder and diabetic ketoacidosis (DKA) at the presentation of pituitary gigantism. The boy complained of lethargy and dysphoric mood in June 2008. He presented at the emergency department with epigastralgia and dyspnea in January 2009. Results of laboratory tests suggested type 1 diabetes mellitus with DKA. However, serum C-peptide level was normal on follow-up. Although he had no obvious features of acral enlargement, a high level of insulin-like growth factor 1 was detected, and a 75 g oral glucose suppression test showed no suppression of serum growth hormone levels. A pituitary macroadenoma was found on subsequent magnetic resonance imaging. The pituitary adenoma was surgically removed, followed by gamma-knife radiosurgery, and Sandostatin long-acting release treatment. He was then administered metformin, 500 mg twice daily, and to date, his serum glycohemoglobin has been <7%.

  11. Are sick individuals weak competitors? Competitive ability of snails parasitized by a gigantism-inducing trematode.

    Directory of Open Access Journals (Sweden)

    Otto Seppälä

    Full Text Available Parasitized individuals are often expected to be poor competitors because they are weakened by infections. Many trematode species, however, although extensively exploiting their mollusc hosts, also induce gigantism (increased host size by diverting host resources towards growth instead of reproduction. In such systems, alternatively to reduced competitive ability due to negative effects of parasitism on host performance, larger size could allow more efficient resource acquisition and thus increase the relative competitive ability of host individuals. We addressed this hypothesis by testing the effect of a trematode parasite Diplostomum pseudospathaceum on the competitive ability of its snail host Lymnaea stagnalis. We experimentally examined the growth of snails kept in pairs in relation to their infection status and intensity of resource competition (i.e. food availability. We found that parasitized snails grew faster and their reproduction was reduced compared to unparasitized individuals indicating parasite-induced gigantism. However, growth of the snails was faster when competing with parasitized individuals compared to unparasitized snails indicating reduced competitive ability due to parasitism. The latter effect, however, was relatively weak suggesting that the effects of the parasite on snail physiology may partly override each other in determining competitive ability.

  12. [Long-term treatment of acromegaly and gigantism with octreotide (SMS 201-995)].

    Science.gov (United States)

    Shimatsu, A; Imura, H; Irie, M; Nakagawa, S; Goto, Y; Shimizu, N; Takeda, R; Kato, Y; Saito, S; Ibayashi, H

    1992-02-20

    Twenty-one patients with active acromegaly and two patients with pituitary gigantism were treated with the long-acting somatostatin analogue octreotide (100-600 micrograms/day, sc, two or three times daily or 300-1500 micrograms daily by intermittent sc infusion) for 9-63 months. There was rapid clinical improvement. The fasting plasma GH levels were significantly suppressed (less than 50% of the values before treatment) in 17 patients and were normalized (less than 5 ng/ml) in 6 patients (27.3%). Plasma IGF-I levels were lowered by 50% and were normalized in 7 out of 18 cases. The effect of octreotide on pituitary tumor size was evaluated in 13 patients. In 4 cases, the shrinkage of the pituitary tumor was detected by computed tomographic scans and/or magnetic resonance imaging studies. The drug was generally well tolerated. However, there were probably newly formed gallstones in two patients during the therapy. Our study suggests that octreotide is an effective and relatively safe new approach for treating active acromegaly and gigantism.

  13. A novel neonatal Michelin Tire Baby Syndrome with craniosynostosis and gigantism

    Directory of Open Access Journals (Sweden)

    Ižbrahim Akalin

    2014-03-01

    Full Text Available     Michelin Tire Baby Syndrome is a rare congenital disorder and characterized clinically well defined multiple ring shaped skin creases. Our patient was born to onconsanguineous healthy parents as the third child of the family at 40 weeks of uneventful gestation with distinctive skin creases and gigantism. He was 4,950 g in weight (>90 percentile, 57.5 cm in length (>90 percentile, and had a head circumferences of 39.5 cm (>90 percentile at birth. The physical examination showed a rough face, brachicephaly and craniosynostosis. His vital and laboratory findings were within normal limits at birth. Cranial and renal ultrasonograms, Xray graphics and cytogenetic analyses were normal. Echocardiography revealed small patent ductus arteriosis and patent foramen ovale. In this report, we present a new case of Michelin Tire Baby Syndrome who is the first neonate associated with severe gigantism and craniosynostosis, in the literature. A review of the related literature has also been presented.

  14. The small but clear gravity signal above the natural cave 'Grotta Gigante' (Trieste, Italy)

    Science.gov (United States)

    Braitenberg, Carla; Sampietro, Daniele; Zuliani, David; Barbagallo, Alfio; Fabris, Paolo; Fabbri, Julius; Rossi, Lorenzo; Handi Mansi, Ahmed

    2014-05-01

    Gravity observations are a powerful means for detecting underground mass changes. The Italian and Slovenian Karst has a number of explored caves, several are also touristic due to their size (e.g. Grotta Gigante in Italy; Skocjianske Jame and Postojnska Jama in Slovenia). Just a few years ago another big cave was discovered by chance close to Trieste when drilling a tunnel for a motor-highway, which shows that more caves are expected to be discovered in coming years. We have acquired the gravity field above the Grotta Gigante cave, a cave roughly 100 m high and 200 m long with a traditional spring-gravity meter (Lacoste&Romberg) and height measurements made with GPS and total station. The GPS was made with two different teams and processing algorithms, to cross-check accuracy and error estimate. Some stations had to be surveyed with a classical instrument due to the vegetation which concealed the satellite positioning signal. Here we present the results of the positioning acquisitions and the gravity field. The cave produces a signal of 1.5 mGal, with a clear elongated concentric symmetry. The survey shows that a systematic coverage of the Karst would have the benefit to recover the position of all of the greater existing caves. This will have a large impact on civil and environmental purposes, since it will for example allow to plan the urban development at a safety distance from subsurface caves.

  15. Prevalencia de quistes odontogénicos: Hospital Regional Valdivia entre los años 1990 y 2010 Prevalence of odontogenic cysts: Hospital Regional Valdivia, between years 1990-2010

    Directory of Open Access Journals (Sweden)

    F.I. Peters

    2012-12-01

    Full Text Available Objetivo: Determinar la prevalencia de quistes odontogénicos en población atendida en el Hospital Regional Valdivia, en el periodo entre 1990-2010, según la última clasificación de lesiones quísticas de la Organización Mundial de la Salud (OMS, 2005. Esta investigación corresponde a un estudio descriptivo de corte transversal censal. Metodología: Se revisaron informes de biopsias del Hospital Regional Valdivia (HRV, durante un periodo de 20 años (1990-2010,seleccionando los informes con diagnósticos histopatológicos de quistes odontogénicos. Las variables a analizar fueron: año de emisión del informe, género y edad del paciente, localización anatómica de la lesión, diagnóstico histopatológico. Los datos se almacenaron en planilla de base de datos para su análisis estadístico. Resultados: De las 1.850 biopsias del territorio maxilofacial evaluadas, la prevalencia de Quistes Odontogénicos alcanzó un 11,9%. Según tipo de quiste, los más prevalente fueron el quiste radicular (84,5%, quiste dentígero (14,1% y quiste residual (0,9%. El de menor prevalencia fue el quiste de erupción (0,5%. Un 52,7% del total de quistes odontogénicos correspondieron al género femenino. El rango de edad de presentación va entre los 4 y los 81 años (promedio 31,7±3,7 años. El área anatómica más afectada es el maxilar superior con 65,5%. Conclusión: Los Quistes odontogénicos son entidades diagnosticadas histopatológicamente en forma variable durante el periodo de tiempo comprendido entre los años 1990 y 2010, en el HRV. Se presentan en mayor frecuencia en mujeres, sin predilección por género, afectando principalmente a la 3ª década de vida. La entidad quística mas prevalente fue el quiste radicular.Objective: Determine the prevalence of Odontological Cysts in the attended patients of Hospital Regional Valdivia, between 1990 and 2010, according to the World Health Organization (WHO classification of tumour like lesions, 2005

  16. Cardiac and metabolic effects of chronic growth hormone and insulin-like growth factor I excess in young adults with pituitary gigantism.

    Science.gov (United States)

    Bondanelli, Marta; Bonadonna, Stefania; Ambrosio, Maria Rosaria; Doga, Mauro; Gola, Monica; Onofri, Alessandro; Zatelli, Maria Chiara; Giustina, Andrea; degli Uberti, Ettore C

    2005-09-01

    Chronic growth hormone (GH)/insulin-like growth factor I (IGF-I) excess is associated with considerable mortality in acromegaly, but no data are available in pituitary gigantism. The aim of the study was to evaluate the long-term effects of early exposure to GH and IGF-I excess on cardiovascular and metabolic parameters in adult patients with pituitary gigantism. Six adult male patients with newly diagnosed gigantism due to GH secreting pituitary adenoma were studied and compared with 6 age- and sex-matched patients with acromegaly and 10 healthy subjects. Morphologic and functional cardiac parameters were evaluated by Doppler echocardiography. Glucose metabolism was assessed by evaluating glucose tolerance and homeostasis model assessment index. Disease duration was significantly longer (Pgigantism than in patients with acromegaly, whereas GH and IGF-I concentrations were comparable. Left ventricular mass was increased both in patients with gigantism and in patients with acromegaly, as compared with controls. Left ventricular hypertrophy was detected in 2 of 6 of both patients with gigantism and patients with acromegaly, and isolated intraventricular septum thickening in 1 patient with gigantism. Inadequate diastolic filling (ratio between early and late transmitral flow velocitygigantism and 1 of 6 patients with acromegaly. Impaired glucose metabolism occurrence was higher in patients with acromegaly (66%) compared with patients with gigantism (16%). Concentrations of IGF-I were significantly (Pgigantism who have cardiac abnormalities than in those without cardiac abnormalities. In conclusion, our data suggest that GH/IGF-I excess in young adult patients is associated with morphologic and functional cardiac abnormalities that are similar in patients with gigantism and in patients with acromegaly, whereas occurrence of impaired glucose metabolism appears to be higher in patients with acromegaly, although patients with gigantism are exposed to GH excess for a

  17. Granuloma central de células gigantes Giant cells central granuloma

    Directory of Open Access Journals (Sweden)

    Ayelén María Portelles Massó

    2011-03-01

    Full Text Available El granuloma reparativo central de células gigantes es una lesión proliferativa no neoplásica de etiología desconocida. Se presenta un paciente masculino de 40 años de edad, portador de prótesis parcial superior. Fue remitido al Servicio de Cirugía Maxilofacial del Hospital "V. I. Lenin" por presentar aumento de volumen en reborde alveolar superior, de color rojo grisáceo y que provocaba expansión de corticales óseas. Una vez analizados los exámenes clínicos, radiográficos e histopatológicos se diagnosticó un granuloma reparativo central de células gigantes Se realizó exéresis quirúrgica de la lesión y extracción de dientes adyacentes con una evolución satisfactoria sin señales de recidivas luego de tres años del tratamiento. El granuloma reparativo central de células gigantes se presentó como respuesta a un trauma. La correcta interpretación de los datos clínicos, radiográficos e histopatológicos nos permitió llegar al correcto diagnóstico y plan de tratamiento.Giant-cell central reparative granuloma is non neoplastic proliferative lesion of unknown etiology. We report a 40 years old male patient who was admitted at the Maxillofacial Service of the "V. I. Lenin" Hospital. The patient had partial upper prosthesis and was complaining of red-grey volume increase lesion in upper alveolar ridge which led to the expansion of cortical bone. Having analyzed clinical, radiographic and histopathological findings the case was concluded as a giant-cell central reparative granuloma. Surgical exeresis and adjunct tooth extraction were done. After three years of treatment, satisfactory follow up without recurrence is reported.

  18. Lipomas gigantes

    Directory of Open Access Journals (Sweden)

    Pietro Accetta

    Full Text Available The authors report two cases of giants lipomas in the gluteal region with 3,9 and 3,1 kg. They make a brief epidemiological presentation and consider diagnosis and treatment. They believe that CT scan is the best image method, as it provides more information about size and relationship with surrounding structures. They are against biopsies and lipoaspiration but stand up for the total exeresis as the best option of treatment.

  19. Familial gigantism

    NARCIS (Netherlands)

    W.W. de Herder (Wouter)

    2012-01-01

    textabstractFamilial GH-secreting tumors are seen in association with three separate hereditary clinical syndromes: multiple endocrine neoplasia type 1, Carney complex, and familial isolated pituitary adenomas.

  20. Familial gigantism

    Directory of Open Access Journals (Sweden)

    Wouter W. de Herder

    2012-01-01

    Full Text Available Familial GH-secreting tumors are seen in association with three separate hereditary clinical syndromes: multiple endocrine neoplasia type 1, Carney complex, and familial isolated pituitary adenomas.

  1. Quiste dentígero que causa deformación facial en un niño. Presentación de un caso

    Directory of Open Access Journals (Sweden)

    Juan Carlos Quintana Díaz

    2012-09-01

    Full Text Available Se presenta un caso interesante de un niño de 13 años que acude a la consulta de Cirugía Máxilofacial por presentar asimetría facial y bucal, además de obstrucción nasal del lado de la deformidad. Después de realizar exámenes de laboratorio y radiográficos se lleva sala de cirugía para realizar la exéresis del canino superior derecho retenido, enuclear la extensa área radiolucida a los rayos X y se reconstruye el defecto óseo residual con Hidroxiapatita en gránulos HAP-200, posteriormente se realiza estudio histopatológico. El diagnóstico definitivo corroboró el presuntivo (quiste dentígero. El paciente evolucionó de forma excelente desapareciendo la deformidad facial y los demás síntomas preoperatorios. El examen radiográfico post-operatorio mostró una excelente reconstrucción y osteo-integración del material empleado.

  2. Hidatidosis cardíaca primaria: quiste hidatídico en aurícula derecha con diseminación pulmonar

    Directory of Open Access Journals (Sweden)

    Christian Muñoz-Guijosa

    2009-01-01

    Full Text Available La hidatidosis es una enfermedad parasitaria producida por la larva del cestodo Echinococcus. El quiste hidatídico, la forma más habitual de presentación, es producida por la especie E. granulosus. la afectación cardíaca es muy rara, produciéndose en aproximadamente el 0,5–2% de los casos. El 65% de los casos de hidatidosis cardíaca se localizan en las cavidades izquierdas. Presentamos el caso de un paciente en el que la primera localización de la enfermedad fue la aurícula derecha (Ad, junto con diseminación pulmonar quística. La localización exclusiva en las cavidades cardíacas derechas y en la arteria pulmonar constituye una presentación clínica inusual. se ha revisado la bibliografía, prestando especial interés en la importancia de las técnicas de imagen disponibles en la actualidad para su diagnóstico, así como la necesidad de un tratamiento quirúrgico precoz para evitar sus posibles complicaciones.

  3. A gigantic, exceptionally complete titanosaurian sauropod dinosaur from southern Patagonia, Argentina.

    Science.gov (United States)

    Lacovara, Kenneth J; Lamanna, Matthew C; Ibiricu, Lucio M; Poole, Jason C; Schroeter, Elena R; Ullmann, Paul V; Voegele, Kristyn K; Boles, Zachary M; Carter, Aja M; Fowler, Emma K; Egerton, Victoria M; Moyer, Alison E; Coughenour, Christopher L; Schein, Jason P; Harris, Jerald D; Martínez, Rubén D; Novas, Fernando E

    2014-09-04

    Titanosaurian sauropod dinosaurs were the most diverse and abundant large-bodied herbivores in the southern continents during the final 30 million years of the Mesozoic Era. Several titanosaur species are regarded as the most massive land-living animals yet discovered; nevertheless, nearly all of these giant titanosaurs are known only from very incomplete fossils, hindering a detailed understanding of their anatomy. Here we describe a new and gigantic titanosaur, Dreadnoughtus schrani, from Upper Cretaceous sediments in southern Patagonia, Argentina. Represented by approximately 70% of the postcranial skeleton, plus craniodental remains, Dreadnoughtus is the most complete giant titanosaur yet discovered, and provides new insight into the morphology and evolutionary history of these colossal animals. Furthermore, despite its estimated mass of about 59.3 metric tons, the bone histology of the Dreadnoughtus type specimen reveals that this individual was still growing at the time of death.

  4. Giants among larges: how gigantism impacts giant virus entry into amoebae.

    Science.gov (United States)

    Rodrigues, Rodrigo Araújo Lima; Abrahão, Jônatas Santos; Drumond, Betânia Paiva; Kroon, Erna Geessien

    2016-06-01

    The proposed order Megavirales comprises the nucleocytoplasmic large DNA viruses (NCLDV), infecting a wide range of hosts. Over time, they co-evolved with different host cells, developing various strategies to penetrate them. Mimiviruses and other giant viruses enter cells through phagocytosis, while Marseillevirus and other large viruses explore endocytosis and macropinocytosis. These differing strategies might reflect the evolution of those viruses. Various scenarios have been proposed for the origin and evolution of these viruses, presenting one of the most enigmatic issues to surround these microorganisms. In this context, we believe that giant viruses evolved independently by massive gene/size gain, exploring the phagocytic pathway of entry into amoebas. In response to gigantism, hosts developed mechanisms to evade these parasites.

  5. "Light" Higgs and warped models: Case for a Gigantic International Hadron Collider

    CERN Document Server

    Soni, Amarjit

    2013-01-01

    The LHC seems to have made a monumental discovery, Higgs-like particle of mass around 125 GeV with properties akin to a Standard Model Higgs. In the context of a warped theory of flavor, which is theoretically very attractive, this suggests Kaluza-Klein particle masses are likely to be above 10 TeV except possibly for a radion. The interpretation of the SM-like Higgs from the perspective of other interesting beyond the SM scenarios is also likely that the relevant scale is higher than accessible to the LHC. In light of these developments, deeper understanding of flavor and other fundamental issues requires a gigantic international hadron collider [GIHC] perhaps with cm energy of $\\approx$ 100 TeV \\cite{2talks}. It is suggested that a {\\it global effort} should be made for constructing this machine for resolving many questions that SM cannot answer.

  6. ecCNO solar neutrinos: A challenge for gigantic ultra-pure liquid scintillator detectors

    Science.gov (United States)

    Villante, F. L.

    2015-03-01

    Neutrinos produced in the Sun by electron capture reactions on 13N, 15O and 17F, to which we refer as ecCNO neutrinos, are not usually considered in solar neutrino analysis since the expected fluxes are extremely low. The experimental determination of this sub-dominant component of the solar neutrino flux is very difficult but could be rewarding since it provides a determination of the metallic content of the solar core and, moreover, probes the solar neutrino survival probability in the transition region at Eν ∼ 2.5 MeV. In this Letter, we suggest that this difficult measure could be at reach for future gigantic ultra-pure liquid scintillator detectors, such as LENA.

  7. Pituitary tumor with gigantism, acromegaly and preclinical Cushing's disease diagnosed from the 10th row.

    Science.gov (United States)

    Tourtelot, John B; Vesely, David L

    2013-08-01

    A 7'3" basketball player was noted to have 2 to 3 times thicker tissue in his hands than 6'10" players by an endocrinologist sitting 10 rows above the player in a basketball arena. This led to the diagnosis of pituitary gigantism where the history revealed that he was 7'3" at 15 years of age. At age 19 when the acryl enlargement was noted, a diagnostic workup revealed elevated growth hormones and insulin-like growth factor 1 (IGF-1) with a 2 × 1.3 cm pituitary tumor. His history suggested that his epiphyseal plates had closed at age 15, and because he continued to produce IGF-1, he now has acromegaly. His elevated adrenocorticotropic hormone (ACTH) before surgery suggests that he also had preclinical Cushing's disease. After pituitary transsphenoidal surgery, all acryl enlargement in hands and ligaments disappeared. His growth hormone, IGF-1 and ACTH returned to normal 2 weeks after surgery.

  8. Gigantic directional asymmetry of luminescence in multiferroic CuB 2O 4

    Science.gov (United States)

    Toyoda, S.; Abe, N.; Arima, T.

    2016-05-01

    In multiferroic materials, luminescence intensities can be direction dependent, i.e., different between the opposite propagating directions of emitted light. However, the effect has not been thought to be used for technological applications, since only small directional asymmetry has been reported so far. Here we show that the effect is robust in multiferroic CuB2O4 . The luminescence intensity changes by about 70 % between the opposite directions of the emission, which is about 100 times larger than the previously reported values. We demonstrate that such a gigantic directional asymmetry of luminescence can be applied to the imaging of canted antiferromagnetic domains. The observation of the effect and its application to magnetic domain imaging are important for a deeper understanding of light-matter interactions as well as technological applications such as optical reading techniques for magnetic memory devices.

  9. Aneurisma gigante da artéria cerebral posterior: (segmento P3) Relato de caso

    OpenAIRE

    1995-01-01

    Apresentamos caso de aneurisma gigante do segmento distal (P3) da artéria cerebral posterior. O aneurisma foi tratado microcirurgicamente pela via combinada proposta por Sano com clipagem do ramo terminal da artéria cerebral posterior próximo ao aneurisma. A paciente teve evolução pós operatória favorável, com lesão parcial e transitória do III nervo craniano. Revisão da literatura e discussão a respeito da anatomia e da abordagem cirúrgica são feitas. A raridade desta patologia justifica o r...

  10. Hepatocarcinoma gigante unifocal en mujer con ingesta prolongada de anticonceptivos hormonales: ¿casualidad o causalidad?

    Directory of Open Access Journals (Sweden)

    VICTOR MANUEL LOPEZ MOURIÑO

    2016-12-01

    Full Text Available Presentamos un caso de una paciente de mediana edad con ingesta mantenida de anticonceptivos hormonales (AH que desarrolla múltiples adenomas hepáticos (asociación bien documentada y un carcinoma hepatocelular (CHC unifocal gigante sin encontrar otros factores de riesgo para el mismo (enolismo, tabaquismo, cirrosis, hemocromatosis,..... Si bien en la literatura no hay unanimidad respecto a la asociación del consumo de AH con el CHC, algunos autores ya contemplaron esa posibilidad, excluyendo también otras etiologías reconocidas de CHC, por lo que debería reevaluarse si su asociación es aleatoria o por el contrario existe nexo causal.

  11. Early descriptions of acromegaly and gigantism and their historical evolution as clinical entities.

    Science.gov (United States)

    Mammis, Antonios; Eloy, Jean Anderson; Liu, James K

    2010-10-01

    Giants have been a subject of fascination throughout history. Whereas descriptions of giants have existed in the lay literature for millennia, the first attempt at a medical description was published by Johannes Wier in 1567. However, it was Pierre Marie, in 1886, who established the term "acromegaly" for the first time and established a distinct clinical diagnosis with clear clinical descriptions in 2 patients with the characteristic presentation. Multiple autopsy findings revealed a consistent correlation between acromegaly and pituitary enlargement. In 1909, Harvey Cushing postulated a “hormone of growth" as the underlying pathophysiological trigger involved in pituitary hypersecretion in patients with acromegaly. This theory was supported by his observations of clinical remission in patients with acromegaly in whom he had performed hypophysectomy. In this paper, the authors present some of the early accounts of acromegaly and gigantism, and describe its historical evolution as a medical and surgical entity.

  12. Gate-tunable gigantic lattice deformation in VO{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Okuyama, D., E-mail: okuyama@riken.jp, E-mail: nakano@imr.tohoku.ac.jp, E-mail: iwasa@ap.t.u-tokyo.ac.jp; Hatano, T. [RIKEN Center for Emergent Matter Science (CEMS), Wako 351-0198 (Japan); Nakano, M., E-mail: okuyama@riken.jp, E-mail: nakano@imr.tohoku.ac.jp, E-mail: iwasa@ap.t.u-tokyo.ac.jp [RIKEN Center for Emergent Matter Science (CEMS), Wako 351-0198 (Japan); Institute for Materials Research, Tohoku University, Sendai 980-8577 (Japan); Takeshita, S.; Ohsumi, H.; Tardif, S. [RIKEN SPring-8 Center, Hyogo 679-5148 (Japan); Shibuya, K. [National Institute of Advanced Industrial Science and Technology, Tsukuba 305-8562 (Japan); Yumoto, H.; Koyama, T.; Ohashi, H. [Japan Synchrotron Radiation Research Institute, SPring-8, Hyogo 679-5198 (Japan); Takata, M. [RIKEN SPring-8 Center, Hyogo 679-5148 (Japan); Japan Synchrotron Radiation Research Institute, SPring-8, Hyogo 679-5198 (Japan); Kawasaki, M.; Tokura, Y.; Iwasa, Y., E-mail: okuyama@riken.jp, E-mail: nakano@imr.tohoku.ac.jp, E-mail: iwasa@ap.t.u-tokyo.ac.jp [RIKEN Center for Emergent Matter Science (CEMS), Wako 351-0198 (Japan); Quantum-Phase Electronics Center and Department of Applied Physics, University of Tokyo, Tokyo 113-8656 (Japan); Arima, T. [RIKEN Center for Emergent Matter Science (CEMS), Wako 351-0198 (Japan); RIKEN SPring-8 Center, Hyogo 679-5148 (Japan); Department of Advanced Materials Science, University of Tokyo, Kashiwa 277-8561 (Japan)

    2014-01-13

    We examined the impact of electric field on crystal lattice of vanadium dioxide (VO{sub 2}) in a field-effect transistor geometry by in-situ synchrotron x-ray diffraction measurements. Whereas the c-axis lattice parameter of VO{sub 2} decreases through the thermally induced insulator-to-metal phase transition, the gate-induced metallization was found to result in a significant increase of the c-axis length by almost 1% from that of the thermally stabilized insulating state. We also found that this gate-induced gigantic lattice deformation occurs even at the thermally stabilized metallic state, enabling dynamic control of c-axis lattice parameter by more than 1% at room temperature.

  13. The Perlman syndrome: familial renal dysplasia with Wilms tumor, fetal gigantism and multiple congenital anomalies. 1984.

    Science.gov (United States)

    Neri, Giovanni; Martini-Neri, Maria Enrica; Katz, Ben E; Opitz, John M

    2013-11-01

    The ensuing paper by Professor Giovanni Neri and colleagues was originally published in 1984, American Journal of Medical Genetics 19:195–207. The original article described a new family with a condition that the authors designated as the Perlman syndrome. This disorder, while uncommon, is an important multiple congenital anomaly and dysplasia syndrome; the causative gene was recently identified. This paper is a seminal work and is graciously republished by Wiley-Blackwell in the Special Festschrift issue honoring Professor Neri. We describe a familial syndrome of renal dysplasia, Wilms tumor, hyperplasia of the endocrine pancreas, fetal gigantism, multiple congenital anomalies and mental retardation. This condition was previously described by Perlman et al. [1973, 1975] and we propose to call it the "Perlman syndrome." It appears to be transmitted as an autosomal recessive trait. The possible relationships between dysplasia, neoplasia and malformation are discussed. © 2013 Wiley Periodicals, Inc.

  14. ecCNO solar neutrinos: A challenge for gigantic ultra-pure liquid scintillator detectors

    Directory of Open Access Journals (Sweden)

    F.L. Villante

    2015-03-01

    Full Text Available Neutrinos produced in the Sun by electron capture reactions on 13N, 15O and 17F, to which we refer as ecCNO neutrinos, are not usually considered in solar neutrino analysis since the expected fluxes are extremely low. The experimental determination of this sub-dominant component of the solar neutrino flux is very difficult but could be rewarding since it provides a determination of the metallic content of the solar core and, moreover, probes the solar neutrino survival probability in the transition region at Eν∼2.5 MeV. In this Letter, we suggest that this difficult measure could be at reach for future gigantic ultra-pure liquid scintillator detectors, such as LENA.

  15. Can oxygen set thermal limits in an insect and drive gigantism?

    Directory of Open Access Journals (Sweden)

    Wilco C E P Verberk

    Full Text Available BACKGROUND: Thermal limits may arise through a mismatch between oxygen supply and demand in a range of animal taxa. Whilst this oxygen limitation hypothesis is supported by data from a range of marine fish and invertebrates, its generality remains contentious. In particular, it is unclear whether oxygen limitation determines thermal extremes in tracheated arthropods, where oxygen limitation may be unlikely due to the efficiency and plasticity of tracheal systems in supplying oxygen directly to metabolically active tissues. Although terrestrial taxa with open tracheal systems may not be prone to oxygen limitation, species may be affected during other life-history stages, particularly if these rely on diffusion into closed tracheal systems. Furthermore, a central role for oxygen limitation in insects is envisaged within a parallel line of research focussing on insect gigantism in the late Palaeozoic. METHODOLOGY/PRINCIPAL FINDINGS: Here we examine thermal maxima in the aquatic life stages of an insect at normoxia, hypoxia (14 kPa and hyperoxia (36 kPa. We demonstrate that upper thermal limits do indeed respond to external oxygen supply in the aquatic life stages of the stonefly Dinocras cephalotes, suggesting that the critical thermal limits of such aquatic larvae are set by oxygen limitation. This could result from impeded oxygen delivery, or limited oxygen regulatory capacity, both of which have implications for our understanding of the limits to insect body size and how these are influenced by atmospheric oxygen levels. CONCLUSIONS/SIGNIFICANCE: These findings extend the generality of the hypothesis of oxygen limitation of thermal tolerance, suggest that oxygen constraints on body size may be stronger in aquatic environments, and that oxygen toxicity may have actively selected for gigantism in the aquatic stages of Carboniferous arthropods.

  16. The Early ULF Signal of the Gigantic Jets Revealed By Hilbert-Huang Transform

    Science.gov (United States)

    Huang, Po-Hsun; Bing-Chih Chen, Alfred

    2015-04-01

    The conventional Fourier analysis on the sferics in ULF and VLF bandpasses has been done for years. Several phenomena e.g. whistler and Schumann resonance have been well studied by the Fourier spectrum comprehensively. But the Fourier analysis is computed by an integration over time, therefore, the temporal resolution is smoothed, and limited not only by the sampling rate but also the size of the integration window. The instantaneous frequency can't be obtained through this conventional approach. We introduce the Hilbert-Huang transform (HHT) instead of Fourier transform to analyze the sferics of TLEs recorded at Lulin observatory. The Hilbert-Huang transform decomposes a signal into so-called intrinsic mode functions (IMF), and derive instantaneous frequency data by differentiating the phase angle yielded by Hilbert transform. Our analysis of HHT on several gigantic jets recorded by ground observation surprisingly revealed an early signal of frequency-change during the phase of the leading jet, and this early signal can not be identified by Fourier analysis. In the phase of leading jet, the amplitude of the sferics remains a constant and no significant features are recognized in the recorded waveform, but an obvious frequency change about 100-200 millisecond prior to the main discharge of the full development jets (FDJs), which can be clearly recognized in the HHT spectra of all observed gigantic jets. From a further simulation, this frequency change is confirmed to come from the nature of the discharge, not an alias or a false signal generated by the analysis method. This early signal may implies an in-cloud discharge process which is suggested by Krehbiel et al. [2008

  17. Pegvisomant therapy in pituitary gigantism: successful treatment in a 12-year-old girl.

    Science.gov (United States)

    Rix, M; Laurberg, P; Hoejberg, A S; Brock-Jacobsen, B

    2005-08-01

    The use of a growth hormone (GH) receptor antagonist, pegvisomant has shown great promise in adults with acromegaly, but experience in paediatric patients is lacking. We aimed to describe the results of pegvisomant therapy in a 12-year-old girl with an aggressive GH-secreting pituitary tumour. To evaluate the ability of pegvisomant therapy to control the effects of peripheral GH excess in a case of pituitary gigantism. Pegvisomant was introduced at 10 mg/day, given subcutaneously, and gradually increased to 20 mg/day until serum IGF-I was normal for age. A large pituitary adenoma with suprasellar extension was diagnosed in a 12-year-old girl with progressive tall stature (178 cm), GH hypersecretion without suppression during oral glucose loading (nadir serum GH, 90 mU/l), high serum IGF-I and serum prolactin levels. Surgical extirpation was not possible because tumour tissue was fibrous and adherent to the optical nerves. Histological examination showed a mixed GH- and prolactin-secreting adenoma with lymphocytic infiltration of B and T cells. Treatment with a dopamine agonist, cabergoline, normalized serum prolactin, but GH secretion was resistant to both somatostatin analogue, octreotide and cabergoline. Radiation followed by pegvisomant therapy titrated up in dose to 20 mg/day led to a marked reduction in GH secretion and normalization of IGF-I, and to growth arrest and improvement of well-being. We suggest that treatment in pituitary gigantism with pegvisomant is safe and may normalize IGF-I levels and effectively stop growing.

  18. Impacto de la dieta sobre la inducción de infección con quistes de Giardia lamblia en ratas Sprague-Dawley The effect of malnourishment on the development of giardiosis in Sprague-Dawley rats

    Directory of Open Access Journals (Sweden)

    Martha Elvia Díaz-Cinco

    2002-07-01

    Full Text Available Objetivo. Evaluar el efecto de la desnutrición en la inducción de la giardiosis con diferentes concentraciones de quistes de Giardia lamblia utilizando como modelo animal ratas Sprague-Dawley. Material y métodos. Es un estudio experimental efectuado entre 1995 y 1999, en el Centro de Investigación en Alimentación y Desarrollo, de la ciudad de Hermosillo, estado de Sonora, México, y cuya muestra estuvo integrada por dos grupos de 6 a 8 unidades experimentales, las cuales recibieron dos tipos de dieta y cinco tratamientos con diferente concentración de inóculo de quistes de Giardia lamblia. Durante la fase experimental se monitoreó la excreción de quistes, ganancia de peso, consumo de alimento, análisis del contenido intestinal y daños macro y microscópicos en mucosa intestinal. El tratamiento estadístico de los datos consistió en análisis de varianza, y de residuales cuando fue necesario. Resultados. En los animales alimentados con una dieta que cubre sus requerimientos nutricionales (DN se observó que es posible provocar la infección con 60 quistes, mientras que en los animales desnutridos (dieta DLN la concentración que se requiere es de únicamente seis quistes para establecer daños a nivel de mucosa intestinal. Conclusiones. La ganancia de peso monitoreada durante los 10 días de ensayo no resultó ser un buen indicador de la infección por Giardia lamblia. El porcentaje de infección depende de la concentración de quistes inoculados y del estado de nutrición de los animales evaluados.Objective. To assess the effect of malnutrition on the development of giardiosis in Sprague-Dawley rats, using different inoculum sizes of Giardia lamblia cysts. Material and Methods. An experimental study was conducted between 1995 and 1999 at Centro de Investigación, Alimentación y Desarrollo (Center for Research, Food, and Development, in Hermosillo, Sonora, Mexico. The study population consisted of two groups of six to eight

  19. Quiste dentígero: diagnóstico y resolución de un caso. Revisión de la literatura Dentigerous cyst: diagnosis and resolution of a case. A review of the literature

    Directory of Open Access Journals (Sweden)

    J. Vázquez Diego

    2008-12-01

    Full Text Available Se presenta un caso clínico de quiste dentígero asociado a un segundo premolar inferior derecho retenido. El paciente de 13 años de edad es de sexo masculino. Se utilizan las técnicas radiográficas extraoral lateral oblicua de rama y la intraoral del paralelo para poder localizar y diagnosticar presuntivamente dicha patología. Posteriormente se realiza la intervención quirúrgica para realizar la extracción del diente retenido y la enucleación del quiste el que es enviado para realizar los estudios anatomopatológicos los que corroboran el diagnóstico presuntivo. Se decide hacer seguimiento del caso. Basado en lo expuesto se analiza al quiste dentígero según ubicación, sexo, edad y maxilar; habiendo realizado una revisión de la literatura.A clinical case of dentigerous cyst associated with an impacted lower right second premolar in a 13-year-old male patient, is reported. An extraoral oblique lateral technique of the ramus and a parallel intraoral technique were used to locate the cyst and to perform a presumptive diagnosis of the lesion. A surgical procedure was then carried out to remove the impacted tooth and also to enucleate the cyst, which was sent to the laboratory for a histo-pathological study; this study confirmed our earlier presumptive diagnosis. Finally, we decided to follow-up the case. Based on our findings, dentigerous cyst is analyzed according to its location, sex and age of patients and most affected jaw, after reviewing the literature on this subject.

  20. PANCREATITIS AGUDA COMO PRESENTACIÓN DE UN QUISTE DEL CONDUCTO BILIAR EN EL ADULTO: REPORTE DE CASO Acute pancreatitis as a presentation of bile duct cyst in adults: a case report

    Directory of Open Access Journals (Sweden)

    Lenin Enríquez Domínguez

    2009-01-01

    Full Text Available Paciente adulta se presentÓ en la sala de urgencias con un cuadro de pancreatitis aguda como complicaciÓn de un quiste del conducto biliar colédoco tipo IV, el cual fue diagnosticado por ultrasonograma abdominal durante su estancia intrahospitalaria. El diagnÓstico de quiste de colédoco es más difícil en la edad adulta ya que los pacientes raramente se presentan con la triada clásica de dolor abdominal, masa palpable e ictericia, presentándose principalmente con alguna manifestaciÓn de vías biliares o pancreática benigna. Existen pocas publicaciones en Occidente acerca de este tÓpico. La importancia en cuanto al diagnÓstico temprano, la clasificaciÓn del mismo y al tratamiento quirúrgico con la resecciÓn total del quiste radica en su alta incidencia hacia el desarrollo de colangiocarcinoma.An adult female patient who attended an ER with acute pancreatitis as a complication of bile duct cyst disease is described here; she was diagnosed by abdominal ultrasonogram during her hospital stay. A diagnosis of bile duct cysts is difficult to make in adults, since patients rarely present the classic picture of abdominal pain, palpable mass and jaundice; it is mainly presented as a biliary duct or pancreatic tissue complication. There are few publications on this topic in the west. A diagnosis can be made by ultrasound in many cases and is the image study of choice due to its low cost and accessibility. These are only few western publications concerning this subject. The importance of making an early diagnosis, classification and surgical treatment (total resection of the cyst lies in the high risk of malignancy developing.

  1. Efectividad y seguridad de la laparotomía vs laparoscopía en abdomen agudo de origen gineco-obstétrico causado por embarazo ectópico roto y quiste de ovario roto.

    OpenAIRE

    2014-01-01

    Comparar efectividad, tiempo y sangrado operatorio, estadía y complicaciones entre laparotomía y laparoscopía en abdomen agudo (AA) por embarazo ectópico roto (EER) y quiste de ovario roto (QOR). Métodos: Estudio retrospectivo en el Hospital de Santa Elena y Clínica Granados de Enero 2010-Diciembre 2011. Se obtuvieron las causas, procedimientos, edad, hemoglobina, edad gestacional, antecedentes personales y complicaciones. Tiempo, sangrado operatorio y estadía fueron comparadas por T de stud...

  2. QUISTES DE MAXILARES Y MANDÍBULA: ALGUNAS CARACTERÍSTICAS CLÍNICAS Y CORRELACIÓN ENTRE EL DIAGNÓSTICO RADIOLÓGICO E HISTOPATOLÓGICO.

    OpenAIRE

    2008-01-01

    Se realizó un estudio retrospectivo en el Departamento de Patología Bucal de la Facultad de Estomatología de Ciudad de la Habana, desde el 2002 hasta el 2006; con el objetivo de identificar algunas características clínicas y la correlación entre el diagnóstico radiológico e histopatológico de los quistes del maxilar y de la mandíbula.A partir de las 1324 biopsias estomatológicas realizadas en el periodo, fueron seleccionas aleatoriamente 662, se procesaron algunas variables de interés y se ca...

  3. QUISTES DE MAXILARES Y MANDÍBULA: ALGUNAS CARACTERÍSTICAS CLÍNICAS Y CORRELACIÓN ENTRE EL DIAGNÓSTICO RADIOLÓGICO E HISTOPATOLÓGICO.

    OpenAIRE

    Rafael Delgado Fernández; Diana Rommy de Quesada Iraizoz; Leopoldo de Quedasa Suarez; Leopoldo Antonio de Quesada Iraizoz

    2008-01-01

    Se realizó un estudio retrospectivo en el Departamento de Patología Bucal de la Facultad de Estomatología de Ciudad de la Habana, desde el 2002 hasta el 2006; con el objetivo de identificar algunas características clínicas y la correlación entre el diagnóstico radiológico e histopatológico de los quistes del maxilar y de la mandíbula.A partir de las 1324 biopsias estomatológicas realizadas en el periodo, fueron seleccionas aleatoriamente 662, se procesaron algunas variables de interés y se ca...

  4. Impacto de la dieta sobre la inducción de infección con quistes de Giardia lamblia en ratas Sprague-Dawley The effect of malnourishment on the development of giardiosis in Sprague-Dawley rats

    OpenAIRE

    Martha Elvia Díaz-Cinco; Martha Nydia Ballesteros-Vázquez; Rosalba Pérez-Morales; Verónica Mata-Haro

    2002-01-01

    Objetivo. Evaluar el efecto de la desnutrición en la inducción de la giardiosis con diferentes concentraciones de quistes de Giardia lamblia utilizando como modelo animal ratas Sprague-Dawley. Material y métodos. Es un estudio experimental efectuado entre 1995 y 1999, en el Centro de Investigación en Alimentación y Desarrollo, de la ciudad de Hermosillo, estado de Sonora, México, y cuya muestra estuvo integrada por dos grupos de 6 a 8 unidades experimentales, las cuales recibieron dos tipos d...

  5. Prevalencia de quistes odontogénicos: Hospital Regional Valdivia entre los años 1990 y 2010 Prevalence of odontogenic cysts: Hospital Regional Valdivia, between years 1990-2010

    OpenAIRE

    F.I. Peters; G.P. López; E.G. Preisler; C.C. Sotomayor; Z.M. Donoso; V.S. Hernández

    2012-01-01

    Objetivo: Determinar la prevalencia de quistes odontogénicos en población atendida en el Hospital Regional Valdivia, en el periodo entre 1990-2010, según la última clasificación de lesiones quísticas de la Organización Mundial de la Salud (OMS), 2005. Esta investigación corresponde a un estudio descriptivo de corte transversal censal. Metodología: Se revisaron informes de biopsias del Hospital Regional Valdivia (HRV), durante un periodo de 20 años (1990-2010),seleccionando los informes con di...

  6. Análisis socioeconómico de la pesquería de calamar gigante en Guaymas, Sonora

    Directory of Open Access Journals (Sweden)

    Francisco Javier de la Cruz-González

    2011-01-01

    Full Text Available En este trabajo hacemos un análisis socioeconómico de la pesquería de calamar gigante en Guaymas, Sonora. Se generó una base de datos con información pesquera y se aplicó una encuesta a pescadores y a trabajadores de la industria del calamar para determinar sus principales características socioeconómicas. Los resultados muestran que esta pesquería ha tenido una participación importante en la estructura productiva del sector pesquero de la región; sin embargo, el repunte en las capturas de calamar gigante en los últimos años ha permitido el crecimiento de esta pesquería, pero no su desarrollo. El documento resalta la necesidad de orientar las políticas de manejo al aprovechamiento integral de este recurso.

  7. Control químico del Nematodo quiste Heterodera trifolii en clavel miniatura Chemical control of the cyst nematode, Heterodera trifolii in miniature carnation

    Directory of Open Access Journals (Sweden)

    Marroquin Alicia

    1991-12-01

    Full Text Available Una de las enfermedades en el cultivo del clavel recientemente registradas en Colombia es el nemátodo quiste, Heterodera trifolii. Un aumento del marchitamiento vascular ocasionado por Fusarium oxysporumof. sp. dianthi se ha observado en algunas fincas afectadas por los dos patógenos. La investigación se realizó para evaluar el efecto de varios productos químicos en el control del nemátodo, en un invernadero comercial con clavel miniatura de la variedad Red Baron. Los fumigantes DD-metilisotiocianato, Dazomet y Metan sodio se aplicaron al suelo antes de la siembra, solos y en combinación con tres nemáticidas no fumiqantes Aldicarb, Carbofuran y Oxamil, en tres épocas de aplicación. Los fumigantes fueron máseficientes para la reducción de la población del nemátodo en el suelo que los nematicidasno fumigantes. El mejor tratamiento fue DD-metilisotiocianato con una reducción del 52% de la población de quistes viables y de 38% en la población de larvas en el suelo, un adelanto de 15 días en la cosecha, un aumento del 9% en rendimiento y del 19% en ingresos netos, en comparación con el Testigo no tratado. Entre los nematicidas no fumigantes, los mejores tratamientos fueron Aldicarb y Carbofuran aplicados en el momento de la siembra y Oxamil aplicado 30 días después de la siembra. La combinación de los fumigantes y de los nematicidas no fumigantes no mejoró el control del nemátodo, el rendimiento y la calidad de las flores, pero si aumentó notablemente los costos de producción.
    One of the diseases recently registered on carnation in Colombia is the cystnematode caused by Heterodera trifolii. An increase of the vascular wilt was observed in some farms affected by the two pathogens. A trial was carried out in a commercial greenhouse with miniature carnation of the variety Red Baron. The fumigants DD memethylisothiocianate, Dazomet and Methamsodium applied to the soil before planting were used alone and in combination with

  8. Polyostotic fibrous dysplasia with gigantism and huge pelvic tumor: a rare case of McCune-Albright syndrome.

    Science.gov (United States)

    Sakayama, Kenshi; Sugawara, Yoshifumi; Kidani, Teruki; Fujibuchi, Taketsugu; Kito, Katsumi; Tanji, Nozomu; Nakamura, Atsushi

    2011-06-01

    We report a rare case of polyostotic fibrous dysplasia on endocrine hyperfunction with elevated human growth hormone and normal serum level of prolactin. There were some differential points of gender, gigantism, endocrine function, and GNAS gene from McCune-Albright syndrome. Malignant transformation was suspected in the pelvic tumor from imaging because rapid growth of the tumor by imaging was observed; however, no malignant change occurred in this case.

  9. Hidatidosis retroperitoneal secundaria a quiste hidatídico de localización hepática Retroperitoneal hydatidosis secondary to hepatic hydatid cyst

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    Katherina A Vizcaychipi

    2012-12-01

    Full Text Available La hidatidosis es una enfermedad de distribución mundial, producida por un platelminto parásito del género Echinococcus. El caso que se presenta corresponde a una paciente con una tumoración fluctuante en el espacio retroperitoneal lumbar, secundaria a un quiste hepático. El diagnóstico inicial de certeza fue dado por el hallazgo de ganchos rostelares de protoescólices en el líquido aspirado de un absceso. Este trabajo describe el cuadro clínico, el diagnóstico y el tratamiento médico-quirúrgico de esta paciente. Se analiza cómo la elaboración de un diagnóstico certero requiere de un análisis adecuado de los antecedentes epidemiológicos, las manifestaciones clínicas, los estudios de imágenes y las pruebas de laboratorio, ya que el conjunto de estos datos confirman el caso.Hydatid disease in a worldwide zoonosis. It is caused by a parasitic platyhelminth of the genus Echinococcus. We present a patient with a fluctuating lumbar tumor in the retroperitoneal space, secondary to a hepatic cyst. The initial diagnosis was made by identification of rostellar hooks from protoscoleces in the fluid aspirated from the abscess. We herein describe the clinical manifestations, diagnosis and medical and surgical treatment of this unusual case and conclude that the development of an accurate diagnosis required a proper analysis of the patient's epidemiological history, clinical manifestations, imaging studies and laboratory tests. A multidisciplinary approach and differential diagnosis is paramount to be able to establish a cause of the disease to deliver appropriate treatment.

  10. Convergent evolution of gigantism in damselflies of Africa and South America? Evidence from nuclear and mitochondrial sequence data.

    Science.gov (United States)

    Groeneveld, Linn F; Clausnitzer, Viola; Hadrys, Heike

    2007-02-01

    Extreme large body size is rare in modern Zygoptera (damselflies). Only the South and Central American damselfly family Pseudostigmatidae and one African species, Coryphagrion grandis, share the morphological trait of gigantism. By means of phylogenetic analyses using two mitochondrial markers (16S rDNA and ND1) and one nuclear marker (EF1) in combination with an existing morphological data set, we trace the evolution of gigantism in damselflies. Individual and combined data sets were analyzed using the maximum parsimony, minimum evolution and maximum likelihood algorithms. Regardless of the algorithm used and the data set analyzed all principal tree topologies support a monophyly of the damselfly taxa displaying giant body size. This supports the view that the evolution of gigantism in damselflies from Africa and South America is not the result of convergent evolution due to strikingly similar habitat preferences, but rather the result of close genealogical relationship. Because modern odonates evolved before the split of Africa from Gondwanaland, the proposed phylogeny suggests that C. grandis represents a Gondwana relict.

  11. Gravity combined with laser-scan in Grotta Gigante: a benchmark cave for gravity studies

    Science.gov (United States)

    Pivetta, Tommaso; Braitenberg, Carla

    2014-05-01

    Laser scanning has become one of the most important topographic techniques in the last decades, due to its ability to reconstruct complex surfaces with high resolution and precision and due to its fast acquisition time. Recently a laser-scan survey has been acquired (Fingolo et al., 2011) in the "Grotta Gigante" cave near Trieste, Italy, the biggest cave worldwide according to the Guinness Awards. In this paper this survey is used to obtain a 3D discretization of the cave with prisms. Then through this new model, with the densities derived from campaign measurements, the exact gravimetric effect of the structure was computed (Nagy et al., 2000) and compared with the gravity observation at the surface. The transition from the cloud of laser-scan points to the prism model was carried out by different computer elaborations; first of all the reduction of the data density through an averaging process that allows to pass from over 10000 points/m2 to less than 10points/m2. Then the whole dataset was filtered from the outliers by the means of a simple quadratic surface that fit the data (Turner, 1999). The reduced data points should be divided into the 2 surfaces of top and bottom, that are used to define the prisms. This step was performed using the local regression method (Loess) to calculate a surface located halfway between top and bottom points. Once the top and bottom interfaces were obtained it was possible to get the final prism representation and calculate the gravity signal. The observed Bouguer field is explained very well by our model and the residuals are used to evaluate possible secondary caves. The final prism model together with the gravity database on surface and inside the cave form a perfect benchmark to test forward and inverse potential field algorithms. References Fingolo M., Facco L., Ceccato A., Breganze C., Paganini P., Cezza M., Grotta Gigante di Trieste. Tra realtà virtuale e rilievi 3D ad alta risoluzione, Veneto Geologi, 75, pp.21-25, 2011

  12. Quiste dentígero asociado con mesiodens: Exposición de un caso, revisión de la literatura y diagnóstico diferencial Dentigerous cyst associated with mesiodens: a case report, literature review and differential diagnostic

    Directory of Open Access Journals (Sweden)

    F.J. Rodríguez Romero

    2011-12-01

    Full Text Available El quiste dentígero es uno de los quistes odontogénicos más frecuentes y están asociados con la corona de un diente no erupcionado o en desarrollo. Cuando se asocian con dientes supernumerarios son poco frecuentes y constituyen el 5-6% de todos los quistes dentígeros. En región maxilar, el 90% de los casos se asocian a mesiodens. El objetivo de este artículo es exponer el caso de una adolescente de 14 años con un quiste dentígero asociado con un diente supernumerario (mesiodens impactado en región maxilar anterior, su manejo dental y revisión de la literatura.Dentigerous cyst is one of the most prevalent types of odontogenic cyst and is associated with crown of an unerupted or developing tooth. Dentigerous cysts associated with supernumerary teeth are rare and estimated to constitute 5-6% of all dentigerous cysts. The vast majority, about 90%, are associated with a maxillary mesiodens. The purpose of this article to report the case of an 14-year-old a teenager with a dentigerous cyst associated with an impacted anterior maxillary supernumerary tooth, its dental management and literature review.

  13. Quistes epidermoides del suelo de boca: presentación de dos casos y revisión de la literatura Epidermoid cysts of the floor of the mouth: presentation of two cases and review of the literature

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    Lorena Sanz

    2010-09-01

    Full Text Available Los quistes epidermoides son una patología frecuente, pero su localización en la cavidad oral es excepcional. Para el abordaje quirúrgico son factores determinantes su tamaño y las relaciones anatómicas. Presentamos dos casos clínicos diagnosticados en el servicio de ORL entre 1999 y 2007, que consultaron por tumoración de crecimiento progresivo en el suelo de boca. Se realiza una revisión acerca del diagnóstico y de los abordajes quirúrgicos de los quistes epidermoides para intentar estandarizar su tratamiento.Epidermoid cysts are a frequent pathology; nevertheless their location in the oral cavity is exceptional. Their size and anatomical location are determining factors in the surgical approach. We present two cases diagnosed in our ENT Department between 1999 and 2007, which were referred to us due to slow growing masses on the floor of the mouth. A literature review was made on the diagnosis, surgical techniques and management of epidermoid cysts in an attempt to standardise their management.

  14. Parâmetros astrofísicos de estrelas gigantes do aglomerado globular 47 Tucanae

    Science.gov (United States)

    Alves-Brito, A.; Barbuy, B.

    2003-08-01

    Os aglomerados globulares são considerados laboratórios astrofísicos para a verificação da teoria de evolução estelar, bem como a trajetória químio-dinâmica das galáxias hospedeiras. Em particular, 47 Tucanae (NGC 104) configura-se como um dos mais extensivamente estudados aglomerados globulares da Galáxia devido a relativa proximidade ao Sol (R¤ = 4.5 kpc) e alta latitute galáctica (b = -44°,89). Neste trabalho, apresentamos a velocidade radial heliocêntrica e os parâmetros atmosféricos (Teff, logg, [Fe/H]) de 5 estrelas gigantes do aglomerado globular 47 Tucanae. Os espectros foram obtidos pelo espectrógrafo UVES (Ultaviolet Visual Echelle Spectrograph) de alta resolução (R = 60000) e alta razão sinal-ruído (S/N > 200), acoplado ao telescópio de 8,2m Kueyen do VLT (Very Large Telescope). Nós encontramos = -22,43 +/- 3,97 km/s, [Fe/H] ~ -0.7, 1,2 aglomerados globulares ricos em metais. Trabalho financiado pela FAPESP e pelo CNPq.

  15. Discovery of gigantic molecular nanostructures using a flow reaction array as a search engine.

    Science.gov (United States)

    Zang, Hong-Ying; de la Oliva, Andreu Ruiz; Miras, Haralampos N; Long, De-Liang; McBurney, Roy T; Cronin, Leroy

    2014-04-28

    The discovery of gigantic molecular nanostructures like coordination and polyoxometalate clusters is extremely time-consuming since a vast combinatorial space needs to be searched, and even a systematic and exhaustive exploration of the available synthetic parameters relies on a great deal of serendipity. Here we present a synthetic methodology that combines a flow reaction array and algorithmic control to give a chemical 'real-space' search engine leading to the discovery and isolation of a range of new molecular nanoclusters based on [Mo(2)O(2)S(2)](2+)-based building blocks with either fourfold (C4) or fivefold (C5) symmetry templates and linkers. This engine leads us to isolate six new nanoscale cluster compounds: 1, {Mo(10)(C5)}; 2, {Mo(14)(C4)4(C5)2}; 3, {Mo(60)(C4)10}; 4, {Mo(48)(C4)6}; 5, {Mo(34)(C4)4}; 6, {Mo(18)(C4)9}; in only 200 automated experiments from a parameter space spanning ~5 million possible combinations.

  16. Lower limb gigantism, lymphedema, and painful varicosities following a thigh vascular access graft.

    Science.gov (United States)

    Thompson, Michael; Mathuram Thiyagarajan, Umasankar; Akoh, Jacob A

    2014-07-01

    Prosthetic arteriovenous grafts (AVGs) are associated with greater morbidity than autogenous arteriovenous fistulas (AVFs), but their use is indicated when AVF formation is not possible. This report adds to the literature a case of lower limb gigantism, painful varicosities, and lymphedema following long-term use of AVG in the upper thigh. The patient's past medical history included renal transplantation on the same side well before the AVG was inserted and right leg deep vein thrombosis. Suspicion of AVG thrombosis was excluded by Doppler ultrasound, which demonstrated an access flow of 1700 mL/min. A computed tomography (CT) scan of the abdomen and pelvis did not identify the cause of her symptoms. Whereas functional incompetence of the iliac vein valve might be responsible for the varicosities, the extent of hypertrophy in this case raises the suspicion of lymphatic blockage possibly secondary to groin dissection undertaken at the time of graft insertion, in addition to the previous dissection at the time of transplantation. This case highlights the need for minimal groin dissection during AVG insertion, particularly in patients with a history of previous abdominopelvic surgery.

  17. A Thermodynamic, kinematic and microphysical analysis of a jet and gigantic jet-producing Florida thunderstorm

    Science.gov (United States)

    Lazarus, S. M.; Splitt, M. E.; Brownlee, James; Spiva, Nicholas; Liu, Ningyu

    2015-08-01

    This paper presents a meteorological analysis of a storm that produced two jets, four gigantic jets (GJ), and a starter, which were observed by two radars as well as the Kennedy Space Center 4-Dimensional Lightning Surveillance System on 3 August 2013 in Central Florida. The work is the first application of dual polarization data to a jet-producing storm and is the fifth case related to a tropical disturbance. The storm environment is consistent with the moist tropical paradigm that characterizes about three quarters of the surface and aircraft observed jet and GJ events. The most unstable (MU) convective available potential energy is not unusual for Florida summer convection and is below the climatological mean for these events. An unusual speed shear layer is located near the storm equilibrium level (EL) and the storm exhibits a tilted structure with CGs displaced upshear. The turbulence, as measured by the eddy dissipation rate, is extreme near the storm top during the event window, consistent with the GJ mixing hypothesis. The individual events are collocated with, and track along, the center axis of the divergent outflow at the EL and occur within the region of the coldest GOES IR temperatures—placing the events within the overshoot. The dual polarization data indicate a deep graupel column, extending above the mixed phase layer, to a 13 km altitude.

  18. Respiratory evolution facilitated the origin of pterosaur flight and aerial gigantism.

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    Leon P A M Claessens

    Full Text Available Pterosaurs, enigmatic extinct Mesozoic reptiles, were the first vertebrates to achieve true flapping flight. Various lines of evidence provide strong support for highly efficient wing design, control, and flight capabilities. However, little is known of the pulmonary system that powered flight in pterosaurs. We investigated the structure and function of the pterosaurian breathing apparatus through a broad scale comparative study of respiratory structure and function in living and extinct archosaurs, using computer-assisted tomographic (CT scanning of pterosaur and bird skeletal remains, cineradiographic (X-ray film studies of the skeletal breathing pump in extant birds and alligators, and study of skeletal structure in historic fossil specimens. In this report we present various lines of skeletal evidence that indicate that pterosaurs had a highly effective flow-through respiratory system, capable of sustaining powered flight, predating the appearance of an analogous breathing system in birds by approximately seventy million years. Convergent evolution of gigantism in several Cretaceous pterosaur lineages was made possible through body density reduction by expansion of the pulmonary air sac system throughout the trunk and the distal limb girdle skeleton, highlighting the importance of respiratory adaptations in pterosaur evolution, and the dramatic effect of the release of physical constraints on morphological diversification and evolutionary radiation.

  19. Proptose causada por adenoma pituitário gigante: relato de caso

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    Pereira Andréa

    2003-01-01

    Full Text Available OBJETIVO: Relatar um caso raro de proptose unilateral associada à paralisia oculomotora e cegueira causados por adenoma pituitário gigante. MÉTODOS: A paciente foi submetida a exame clínico e oftalmológico completo, campimetria, exame de imagem por ressonância magnética e estudo histopatológico do tumor após intervenção cirúrgica. RESULTADOS: Paciente de 21 anos apresentou perda visual progressiva bilateral associada à proptose e limitação da motilidade ocular do olho esquerdo. A campimetria revelou hemianopsia temporal completa no olho direito e havia ausência de percepção luminosa no olho esquerdo. O exame de imagem por ressonância magnética mostrou extenso tumor infiltrando o terceiro ventrículo, seio cavernoso e ápice da órbita à esquerda. O estudo histopatológico revelou se tratar de adenoma hipofisário produtor de hormônio de crescimento e prolactina sem sinais de malignidade. CONCLUSÃO: Este caso é de interesse não apenas pelo fato do envolvimento orbitário pelos adenomas ser extremamente raro, mas também para salientar a importância de diagnóstico precoce uma vez que apesar da histologia benigna, os adenomas invasivos nem sempre seguem curso clínico favorável.

  20. Evolución de planetas gigantes y posibilidades de su detección directa

    Science.gov (United States)

    Brunini, A.; Benvenuto, O. G.

    Desde la reciente detección de planetas gigantes orbitando estrellas cercanas de tipo solar por medio de efecto Doppler, uno de los principales problemas, en cuanto al estudio de los sistemas planetarios extrasolares, se refiere a la posibilidad de obtener evidencia directa de su existencia. Esto parece ser factible gracias a que en un futuro cercano entrarán en operación algunos telescopios especialmente adecuados a estos propósitos. Por tal motivo, hemos comenzado desde hace un tiempo un esfuerzo en cuanto al estudio de la evolución planetaria. A tales efectos hemos adaptado el código de evolución estelar de nuestro Observatorio al caso planetario. Las principales diferencias entre el caso estelar y el planetario se encuentran en la ecuación de estado. A tales fines hemos incluído la reciente ecuación de estado de Saumon, Chabrier y Van Horn, las opacidades radiativas de Guillot et al., procesos de quema de Deuterio, etc. También se ha considerado la posible existencia de fases de hielo y roca en el interior planetario. Por el momento hemos despreciado los efectos de la rotación planetaria. Con este código hemos computado la evolución de planetas con masas desde 10 hasta 0.3 masas de Júpiter. Utilizando nuestros resultados numéricos discutimos la detectabilidad de estos objetos en condiciones realistas.

  1. Futures, fakes and discourses of the gigantic and miniature in ‘The World’ islands, Dubai

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    Pamila Gupta

    2015-11-01

    Full Text Available This article takes the “island” as a key trope in tourism studies, exploring how ideas of culture and nature, as well as those of paradise (lost are central to its interpretation for tourists and tourist industries alike. Increasingly, however, island tourism is blurring the line between geographies of land and water, continent and archipelago, and private and public property. The case of ‘The World’ islands mega project off the coast of Dubai (UAE is used to chart the changing face and future of island tourism, exploring how spectacle, branding and discourses of the gigantic, miniature, and fake, particularly alongside technological mediations on a large-scale, reflect the postmodern neoliberal world of tourism and the liquid times in which we live. Artificial island complexes such as this one function as cosmopolitan ‘non-places’ at the same time that they reflect a resurgence in (British nascent nationalism and colonial nostalgia, all the whilst operating in a sea of ‘junkspace’. The shifting cartography of ‘the island’ is thus mapped out to suggest new forms of place-making and tourism’s evolving relationship to these floating islandscapes.

  2. O serviço de enfermagem hospitalar - apresentando este gigante silencioso

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    Gisela Maria Schebella Souto de Moura

    2001-09-01

    Full Text Available O artigo focaliza a importância do serviço de enfermagem nas organizações de saúde, metaforizando sua grandeza com a expressão "gigante" e seu pouco reconhecimento pela comunidade através do termo "silencioso". A abrangência e a complexidade de seu funcionamento é pontual na efetividade dos processos de cuidado em saúde, no entanto, sua estrutura e organização é pouco conhecida pelos demais profissionais de saúde e quase que totalmente desconhecida pela comunidade. O serviço de enfermagem congrega grande contingente de pessoal com diferentes níveis de formação. O planejamento, organização, estrutura e funcionamento deste serviço seguem as diretrizes emanadas da Teoria Geral da Administração e os conhecimentos desta área têm sido cada vez mais utilizados para atingir as metas e objetivos almejados pelas instituições de saúde. O ensaio, contudo, não deixa de abordar questões sobre o foco no cliente e qualidade do atendimento, apontando para a necessidade de repensar o modelo administrativo adotado buscando sempre alternativas sistêmicas e contingenciais.

  3. Discovery of gigantic molecular nanostructures using a flow reaction array as a search engine

    Science.gov (United States)

    Zang, Hong-Ying; de La Oliva, Andreu Ruiz; Miras, Haralampos N.; Long, De-Liang; McBurney, Roy T.; Cronin, Leroy

    2014-04-01

    The discovery of gigantic molecular nanostructures like coordination and polyoxometalate clusters is extremely time-consuming since a vast combinatorial space needs to be searched, and even a systematic and exhaustive exploration of the available synthetic parameters relies on a great deal of serendipity. Here we present a synthetic methodology that combines a flow reaction array and algorithmic control to give a chemical ‘real-space’ search engine leading to the discovery and isolation of a range of new molecular nanoclusters based on [Mo2O2S2]2+-based building blocks with either fourfold (C4) or fivefold (C5) symmetry templates and linkers. This engine leads us to isolate six new nanoscale cluster compounds: 1, {Mo10(C5)}; 2, {Mo14(C4)4(C5)2}; 3, {Mo60(C4)10}; 4, {Mo48(C4)6}; 5, {Mo34(C4)4}; 6, {Mo18(C4)9}; in only 200 automated experiments from a parameter space spanning ~5 million possible combinations.

  4. A gigantic new dinosaur from Argentina and the evolution of the sauropod hind foot

    Science.gov (United States)

    González Riga, Bernardo J.; Lamanna, Matthew C.; Ortiz David, Leonardo D.; Calvo, Jorge O.; Coria, Juan P.

    2016-01-01

    Titanosauria is an exceptionally diverse, globally-distributed clade of sauropod dinosaurs that includes the largest known land animals. Knowledge of titanosaurian pedal structure is critical to understanding the stance and locomotion of these enormous herbivores and, by extension, gigantic terrestrial vertebrates as a whole. However, completely preserved pedes are extremely rare among Titanosauria, especially as regards the truly giant members of the group. Here we describe Notocolossus gonzalezparejasi gen. et sp. nov. from the Upper Cretaceous of Mendoza Province, Argentina. With a powerfully-constructed humerus 1.76 m in length, Notocolossus is one of the largest known dinosaurs. Furthermore, the complete pes of the new taxon exhibits a strikingly compact, homogeneous metatarsus—seemingly adapted for bearing extraordinary weight—and truncated unguals, morphologies that are otherwise unknown in Sauropoda. The pes underwent a near-progressive reduction in the number of phalanges along the line to derived titanosaurs, eventually resulting in the reduced hind foot of these sauropods.

  5. Change in the immunophenotype of a somatotroph adenoma resulting in gigantism

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    Jayesh P Thawani

    2014-01-01

    Full Text Available Background: Examining the pathologic progression of a pituitary adenoma from the point of a prepubescent child to an adult with gigantism affords us an opportunity to consider why patients may develop secretory or functioning tumors and raises questions about whether therapeutic interventions and surveillance strategies could be made to avoid irreversible phenotypic changes. Case Description: A patient underwent a sublabial transsphenoidal resection for a clinically non-functioning macroadenoma in 1999. He underwent radiation treatment and was transiently given growth hormone (GH supplementation as an adolescent. His growth rapidly traversed several percentiles and he was found to have elevated GH levels. The patient became symptomatic and was taken for a second neurosurgical procedure. Pathology and immunohistochemical staining demonstrated a significantly higher proportion of somatotroph cells and dense granularity; he was diagnosed with a functional somatotroph adenoma. Conclusions: While it is likely that the described observations reflect the manifestations of a functional somatotroph adenoma in development, it is possible that pubertal growth, GH supplementation, its removal, or radiation therapy contributed to the described endocrine and pathologic changes.

  6. Investigación experimental de la equinococosis canina a partir de quiste hidatídico de origen porcino en México

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    Ismael Zuñiga-A

    1999-06-01

    Full Text Available OBJETIVO: Para evaluar la infección y obtener el estado adulto del cestodos, se buscó reproducir la equinococosis en perros a partir de quiste hidatídico de origen porcino. MÉTODOS: Se formaron 2 grupos, uno de 5 y otro de 3 perros, a cada animal del grupo experimental se le dió 2 g de membrana germinativa de quíste hidatídico fértil por vía oral, el segundo grupo fue testigo. Ambos grupos fueron evaluados clínica, serológica y parasitológicamente, en el grupo experimental se sacrificó un animal el día 35 de la infección y los siguientes cada 5 dias hasta el 55, en el segundo grupo todos se sacrificaron el día 55. Se observaron huevos del cestodos en heces a partir del dia 51 postinfección. La evaluación morfológica se realizó mediante observación microscópica del raspado de mucosa intestinal. RESULTADOS: De 50 cestodos analizados, 10 de cada uno de los perros infectados, 49 (98% presentaron 3 proglótidos y 1 (2% tenía 4; 18 (36% de los cestodos presentaban un proglótido grávido. La longitud de los estróbilos varió de 1,6 a 2,6 mm. El número promedio de los ganchos largos y cortos fue de 31 y 34 respectivamente. La longitud de los ganchos largos varió entre 0,081 y 0,09 mm, los ganchos cortos fluctuaron entre 0,034 y 0,041 mm. En los perros evaluados clínicamente, el número de leucocitos y la cantidad de proteínas plasmáticas fue significativamente mayor en el grupo testigo (P < 0,05; la cantidad de alfa globulinas fue mayor en el grupo infectado (P < 0,05. CONCLUSIONES: Los resultados permiten confirmar el ciclo perro-cerdo y una infección subclínica en los huéspedes definitivos, lo que dificulta su diagnóstico y control en una especie intimamente relacionada con el hombre.

  7. Investigación experimental de la equinococosis canina a partir de quiste hidatídico de origen porcino en México

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    Zuñiga-A Ismael

    1999-01-01

    Full Text Available OBJETIVO: Para evaluar la infección y obtener el estado adulto del cestodos, se buscó reproducir la equinococosis en perros a partir de quiste hidatídico de origen porcino. MÉTODOS: Se formaron 2 grupos, uno de 5 y otro de 3 perros, a cada animal del grupo experimental se le dió 2 g de membrana germinativa de quíste hidatídico fértil por vía oral, el segundo grupo fue testigo. Ambos grupos fueron evaluados clínica, serológica y parasitológicamente, en el grupo experimental se sacrificó un animal el día 35 de la infección y los siguientes cada 5 dias hasta el 55, en el segundo grupo todos se sacrificaron el día 55. Se observaron huevos del cestodos en heces a partir del dia 51 postinfección. La evaluación morfológica se realizó mediante observación microscópica del raspado de mucosa intestinal. RESULTADOS: De 50 cestodos analizados, 10 de cada uno de los perros infectados, 49 (98% presentaron 3 proglótidos y 1 (2% tenía 4; 18 (36% de los cestodos presentaban un proglótido grávido. La longitud de los estróbilos varió de 1,6 a 2,6 mm. El número promedio de los ganchos largos y cortos fue de 31 y 34 respectivamente. La longitud de los ganchos largos varió entre 0,081 y 0,09 mm, los ganchos cortos fluctuaron entre 0,034 y 0,041 mm. En los perros evaluados clínicamente, el número de leucocitos y la cantidad de proteínas plasmáticas fue significativamente mayor en el grupo testigo (P < 0,05; la cantidad de alfa globulinas fue mayor en el grupo infectado (P < 0,05. CONCLUSIONES: Los resultados permiten confirmar el ciclo perro-cerdo y una infección subclínica en los huéspedes definitivos, lo que dificulta su diagnóstico y control en una especie intimamente relacionada con el hombre.

  8. Acromegaly and gigantism in the medical literature. Case descriptions in the era before and the early years after the initial publication of Pierre Marie (1886).

    Science.gov (United States)

    de Herder, Wouter W

    2009-01-01

    In 1886 Pierre Marie used the term "acromegaly" for the first time and gave a full description of the characteristic clinical picture. However several others had already given clear clinical descriptions before him and sometimes had given the disease other names. After 1886, it gradually became clear that pituitary enlargement (caused by a pituitary adenoma) was the cause and not the consequence of acromegaly, as initially thought. Pituitary adenomas could be found in the great majority of cases. It also became clear that acromegaly and gigantism were the same disease but occurring at different stages of life and not different diseases as initially thought. At the end of the 19th and beginning of the 20th century most information was derived from case descriptions and post-mortem examinations of patients with acromegaly or (famous) patients with gigantism. The stage was set for further research into the pathogenesis, diagnosis and therapy of acromegaly and gigantism.

  9. Efficacy and safety of long-acting pasireotide in Japanese patients with acromegaly or pituitary gigantism: results from a multicenter, open-label, randomized, phase 2 study.

    Science.gov (United States)

    Tahara, Shigeyuki; Murakami, Mami; Kaneko, Tomomi; Shimatsu, Akira

    2017-07-28

    A multicenter, open-label, phase 2 study was conducted to investigate the efficacy and safety of long-acting pasireotide formulation in Japanese patients with acromegaly or pituitary gigantism. Medically naïve or inadequately controlled patients (on somatostatin analogues or dopamine agonists) were included. Primary end point was the proportion of all patients who achieved biochemical control (mean growth hormone [GH] levelsacromegaly, n=32; pituitary gigantism, n=1) were enrolled and randomized 1:1:1 to receive open-label pasireotide 20mg, 40mg, or 60mg. The median age was 52 years (range, 31-79) and 20 patients were males. At month 3, 18.2% of patients (6/33; 90% confidence interval: 8.2%, 32.8%) had biochemical control (21.2% [7/33] when including a patient with mean GHacromegaly or pituitary gigantism.

  10. Fractura patológica de la mandíbula asociada a quiste radicular: Reporte de 3 casos clínicos Mandibular pathologic fracture associated with radicular cyst: Report of three clinical cases

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    J. Bouguila

    2008-08-01

    Full Text Available Introducción. El quiste radicular es el quiste más común de los maxilares. Su tamaño puede variar desde una lesión que abarca el proceso alveolar hasta uno extenso que oblitera el espacio antral maxilar o causa una fractura patológica mandibular. Reporte de casos. Se reportan tres casos con fractura patológica mandibular asociados a quiste radicular ocurridos después de trauma facial. El diagnóstico fue sugerido por un estudio clínico, radiografía panorámica y confirmado por el estudio histopatológico de la pieza operatoria. El tratamiento consistió en enucleación quística seguido por inmovilización de fragmentos con osteosíntesis o bloqueo intermaxilar. El resultado clínico y radiológico a corto plazo fue favorable. Discusión. Se discuten aspectos propios de la patología y su terapia. Conclusión. El éxito del tratamiento depende de una adecuada terapia en que sus principios más importantes son la remoción de la lesión mediante enucleación y una fijación estable.Introduction. Radicular cyst is the most common cyst of the oral cavity. It may range in size from a small periapical lesion to one that can obliterate the antral space or cause mandibular fracture. Case reports. We report three cases of radicular cyst complicated by mandibular fracture that occurred after maxillofacial trauma. The diagnosis was strongly suggested by panoramic radiography and confirmed by pathology examination of the operative specimen. Treatment consisted in cyst enucleation followed by immobilization of fragments by osteosynthesis or maxillomandibular fixation. The clinical and radiologic outcome was favorable. Discussion. The particularities and treatment are discussed. Conclusion. Treatment success is dependent on adequate therapy, the principles of which are removing the lesion and providing stable fixation.

  11. Giant retroperitoneal lipoma: a case report Lipoma gigante do retroperitônio: relato de caso

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    Carlos Augusto Real Martinez

    2003-12-01

    Full Text Available BACKGROUND: Retroperitoneal lipoma is an extremely rare neoplasm. AIMS: The authors report a case of giant retroperitoneal lipoma in a 32-year-old white female, with a history of pain and an abdominal mass over a 2-year period. Total abdominal ultrasonography and barium enema showed a large mass located in the retroperitoneal space behind the ascending colon. Laparotomy showed a large encapsulated tumor measuring 20 x 13 x 10 cm and weighing 3.400 g. The histological study revealed a benign neoplasm of fatty cells. CONCLUSION: The patient remains well 17 years after surgery, without recurrentce of the disease.RACIONAL: O lipoma é a neoplasia mesenquimal mais freqüente, raramente localizada no retroperitônio. Na maioria das vezes, o diagnóstico diferencial pré-operatório com os lipossarcomas de baixo grau de malignidade é difícil de ser estabelecido. OBJETIVO: Apresentar um caso de lipoma gigante retroperitoneal em mulher de 32 anos que há 2 anos apresentava história de dor e tumor abdominal palpável. A ultra-sonografia abdominal e o enema opaco mostraram grande massa localizada no retroperitônio, que deslocava o ceco e o cólon ascendente. A laparotomia mostrou tumor encapsulado com 20 x 13 x 10 cm e 3.400 g de peso. O estudo histopatológico mostrou presença de lipoma retroperitonial. A paciente encontra-se bem, sem recidiva da doença, 17 anos após a cirurgia.

  12. Similarity Analysis of the Streamer Zone of Blue Jets and Gigantic Blue Jets

    Science.gov (United States)

    Gennady, M.; Popov, N. A.; Shneider, M.

    2015-12-01

    Multiple observations of Blue Jets (BJ) and Gigantic Blue Jets (GBJ) show that BJ emits a fan of streamers similar to a laboratory leader. Moreover, in the exponential atmosphere those long streamers grow preferentially upward, producing a narrow cone confined by the aperture angle. Petrov and Petrova [1999] and Pasko and George [2002] noticed that BJ are similar to the streamer zone of a leader (streamer corona) and conducted modeling studies based on the streamers fractal structure. Objective of this paper is to study the fractal dimension of the bunch of streamer channels emitted by BJ, at different altitude and under the varying reduced electric field. This similarity analysis has been done in three steps: First we described the dendritic structure of streamers in corona discharge applying the fractal theory by Popov [2002]. Then using this model and the data from existing laboratory experiments we obtained that the fractal dimension of the branching streamer channels D=2. We estimated next the packing factor of the streamers using the kinetic simulations that describe development of a group of streamers that propagate in a discharge gap while interact with each other. Finally the model was used to analyze some GBJ images available from the literature. The model output includes evaluation of the total number of streamer channels in the GBJs along with estimates of the aperture angle and of the average distance between the brunches. In addition the analysis allows us to obtain the mean streamer velocity for the studied GBJs and check the velocity against the observations. V.P. Pasko and J.J. George, J. Geophys. Res. 107, 1458, 2002 N.I. Petrov and G.N. Petrova, Tech Phys. Lett., 44, 472, 1999 N.A. Popov, Plasma Phys. Reports, 28, 615, 2002.

  13. New color images of sprites, halos and gigantic jets from the International Space Station

    Science.gov (United States)

    Yair, Y.; Rubanenko, L.; Mezuman, K.; Elhalel, G.; Pariente, M.; Glickman-Pariente, M.; Ziv, B.; Takahashi, Y.; Inoue, T.

    2012-12-01

    During July-August 2011, Expedition 28/29 JAXA astronaut Satoshi Furukawa conducted TLE observations from the International Space Station in conjunction with the "Cosmic Shore" program produced by NHK. An EMCCD normal video-rate color TV camera was used to conduct directed observations from the Earth-pointing Copula module. The target selection was based on the methodology developed for the MEIDEX sprite campaign on board the space shuttle Columbia in January 2003 (Ziv et al., 2004). We used the Aviation Weather Center (http://aviationweather.gov) daily significant weather forecast maps (SIGWX) to select regions with high probability for convective activity and thunderstorm such that they were within the camera FOV as deduced from the ISS trajectory and distance to the limb (2240 km). For increasing the chance for successful observations, only storms with predicted "Frequent Cb" and cloud tops above 45 Kft (~14 km) were selected. Additionally, we targeted tropical storms and hurricanes over the oceans. The observation geometry was pre-determined and uploaded daily to the ISS with pointing options to limb, oblique or nadir, based on the predicted location of the storm with regards to the ISS. The pointing angle was rotated in real-time according to visual eyesight by the astronaut. We present results of 10 confirmed TLEs: 8 sprites, 1 sprite halo and 1 gigantic jet, out of displaced form the lightning light and (b) from oblique view of a sprite halo, enable the calculation of dimensions and volumes occupied by these TLEs. Since time stamping on the ISS images was accurate within 1 s, matching with ELF and WWLLN data for the parent lightning location is limited. Nevertheless, the results prove that the ISS is an ideal platform for lightning and TLE observations, and careful operational procedures greatly enhance the value of observation time.;

  14. Cisto hidático pulmonar gigante: relato de um caso Giant hydatid lung cyst: a case report

    Directory of Open Access Journals (Sweden)

    Roger Klein Moreira

    2001-06-01

    Full Text Available Os autores relatam o caso de um paciente do sexo masculino, com 55 anos de idade, branco, com diagnóstico radiológico e histopatológico pós-cirúrgico de cisto hidático pulmonar gigante. A epidemiologia, fisiopatologia e características radiológicas desta doença são discutidas.The authors report a case of a 55-year-old white male patient with radiological and postsurgical histopathological diagnosis of a giant lung hydatid cyst. The epidemiological, physiopathological and radiological findings of this disease are discussed.

  15. Anemia hemolítica autoinmune en un niño con hepatitis de células gigantes

    OpenAIRE

    Jessica Gómez; Kathia Valverde

    2012-01-01

    La asociación de anemia hemolítica autoinmune (AHAI) con hepatitis de células gigantes (HCG) es un trastorno raro en la infancia. Son pocos los casos reportados y la gran mayoría fallecen a pesar de transplante hepático. La AHAI usualmente precede el desarrollo de la afección hepática. El diagnóstico temprano de esta asociación y el inicio de terapia inmunosupresora previene la progresión de la enfermedad.

  16. Anemia hemolítica autoinmune en un niño con hepatitis de células gigantes

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    Jessica Gómez

    2012-12-01

    Full Text Available La asociación de anemia hemolítica autoinmune (AHAI con hepatitis de células gigantes (HCG es un trastorno raro en la infancia. Son pocos los casos reportados y la gran mayoría fallecen a pesar de transplante hepático. La AHAI usualmente precede el desarrollo de la afección hepática. El diagnóstico temprano de esta asociación y el inicio de terapia inmunosupresora previene la progresión de la enfermedad.

  17. Anemia hemolítica autoinmune en un niño con hepatitis de células gigantes

    OpenAIRE

    Jessica Gómez; Kathia Valverde

    2012-01-01

    La asociación de anemia hemolítica autoinmune (AHAI) con hepatitis de células gigantes (HCG) es un trastorno raro en la infancia. Son pocos los casos reportados y la gran mayoría fallecen a pesar de transplante hepático. La AHAI usualmente precede el desarrollo de la afección hepática. El diagnóstico temprano de esta asociación y el inicio de terapia inmunosupresora previene la progresión de la enfermedad.

  18. El maíz blanco gigante Cusco, una propuesta estratégica para su exportación a España

    OpenAIRE

    2007-01-01

    El maíz blanco gigante Cusco es una variedad representativa del maíz amiláceo, cuyas características principales son su singular tamaño (15 mm), su forma (plano circular) y su rendimiento. Su cultivo se ubica de manera exclusiva en el Valle Sagrado de los Incas (Cusco), lo que le ha permitido la obtención de la denominación de origen. La tesis ha delineado un conjunto de estrategias orientadas a desarrollar la oferta exportable del maíz blanco gigante Cusco hacia el mercado español como...

  19. Diagnóstico y tratamiento de los quistes de colédoco: Presentación de 10 nuevos casos Diagnosis and management of choledochal cysts: A review of 10 new cases

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    R. Uribarrena Amezaga

    2008-02-01

    Full Text Available Objetivo: analizar las técnicas diagnósticas y las distintas posibilidades terapéuticas de esta rara patología. Pacientes y métodos: presentamos un estudio retrospectivo de todos los casos de quistes de colédoco diagnosticados en nuestro hospital desde 1991. Incluye 10 nuevos casos y distintos tipos de quistes de colédoco (QC. Resultados: de los 10 pacientes diagnosticados de QC siete tenían menos de 10 años. En cuanto a los diferentes tipos de QC: 7 eran de tipo I, 1 de tipo III, 1 de tipo IVa y otro de tipo V. Las manifestaciones clínicas habitualmente tenían un perfil biliar o pancreático. El diagnóstico se ha realizado mediante técnicas de imagen no invasivas (ECO, TAC y CPRE. El tratamiento ha venido condicionado por el tipo de quiste: quistectomía con hepaticoyeyunostomía en "Y de Roux" en los de tipo I, CPRE con esfinterotomía endoscópica en los de tipo III y trasplante hepático en la enfermedad de Caroli. En el único QC tipo IVa se realizó una papilotomía transductal y una colecistectomía. Todos han sido controlados periódicamente, sin que hayamos registrado complicaciones relevantes durante el seguimiento. Conclusión: los QC son más frecuentes en niños pero no son excepcionales en adultos. Las técnicas de imagen y la CPRE son esenciales en el diagnóstico de esta patología. El tratamiento dependerá del tipo de quiste de colédoco. Es aconsejable el seguimiento periódico y prolongado de estos pacientes para detectar precozmente complicaciones como la transformación maligna.Aim: the aim of this study was to analyze the diagnostic and therapeutic options for the various types of this rare disease. Patients and methods: 10 patients with choledochal cysts (CC were diagnosed in our hospital since 1991. Type of cyst was established according to the Alonso-Lej classification. Results: we report 7 type-I, 1 type-III, 1 type-IVa, and 1 type-V CC cases. Clinical manifestations were abdominal pain in all cases with

  20. Quistes del mesenterio y epiplón en niños: Estudio de 20 años Cysts of the mesentery and omentum in children: A 20-year study

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    Vivian Vialat Soto

    2004-09-01

    Full Text Available Se realiza un estudio de 8 casos operados con diagnóstico de quistes de epiplón o mesenterio en el período de enero de 1982 a diciembre de 2001, en el Hospital Pediátrico universitario Centro Habana. Estas son lesiones intraabdominales raras, que con frecuencia evolucionan como una tumoración asintomática, pero en ocasiones pueden ser causas de abdomen agudo en el niño. Más frecuente en el sexo femenino y todos menores de 10 años de edad. Las radiografías simple de abdomen y el ultrasonido abdominal aportan gran positividad en el diagnostico de estas afecciones. En todos los casos se realizo exéresis total de la lesión tumoral benigna; 3 casos eran quistes del mesenterio del intestino delgado y 5 casos linfangiomas quísticos del epiplón mayor. En 2 pacientes fue necesario realizar resección intestinal para la exéresis del tumor. No hubo complicaciones en nuestros casos.A study of 8 cases operated on with diagnosis of omentum or mesentery cysts from January 1982 to December 2001 at "Centro Habana" Teaching Pediatric Hospital was conducted. These are rare intraabdominal lesions that frequently evolve as an asymptomatic tumor, but on ocassions may be causes of acute abdomen in the child. They were more common among females and all the affected were under 10. The simple X-rays of the abdomen and the abdominal ultrasound showed great positivity in the diagnosis of these affections. Total exeresis of the benign tumoral lesion was performed in all cases. 3 cases were cysts of the mesentery of the small intestine and 5 were cystic lymphangiomas of the greater omentum . In 2 patients, it was necessary to perform intestinal resection for the tumor exeresis. There were no complications.

  1. A novel germline mutation in the aryl hydrocarbon receptor-interacting protein (AIP) gene in an Italian family with gigantism.

    Science.gov (United States)

    Urbani, C; Russo, D; Raggi, F; Lombardi, M; Sardella, C; Scattina, I; Lupi, I; Manetti, L; Tomisti, L; Marcocci, C; Martino, E; Bogazzi, F

    2014-10-01

    Acromegaly usually occurs as a sporadic disease, but it may be a part of familial pituitary tumor syndromes in rare cases. Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene have been associated with a predisposition to familial isolated pituitary adenoma. The aim of the present study was to evaluate the AIP gene in a patient with gigantism and in her relatives. Direct sequencing of AIP gene was performed in fourteen members of the family, spanning among three generations. The index case was an 18-year-old woman with gigantism due to an invasive GH-secreting pituitary adenoma and a concomitant tall-cell variant of papillary thyroid carcinoma. A novel germline mutation in the AIP gene (c.685C>T, p.Q229X) was identified in the proband and in two members of her family, who did not present clinical features of acromegaly or other pituitary disorders. Eleven subjects had no mutation in the AIP gene. Two members of the family with clinical features of acromegaly refused either the genetic or the biochemical evaluation. The Q229X mutation was predicted to generate a truncated AIP protein, lacking the last two tetratricopeptide repeat domains and the final C-terminal α-7 helix. We identified a new AIP germline mutation predicted to produce a truncated AIP protein, lacking its biological properties due to the disruption of the C-terminus binding sites for both the chaperones and the client proteins of AIP.

  2. Pelletization of seeds of Raphanus sativus L. cv. Redondo Gigante with graphite for germination under water stress conditions

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    Nobel Penteado Freitas

    2000-01-01

    Full Text Available The effect of water stress on germination of radish seeds is dependent on the presence of light. The effect of pelletization of radish seeds with powdered graphite on the tolerance to water stress under light was analysed. White light and far-red lights were filtered by graphite increasing slightly the tolerance of pelleted seeds to water stress of -0.77MPa. Although red light also inhibited seed germination the graphite had no effect. We propose the pelletization of seeds of Raphanus sativus, at least in cv redondo gigante with graphite as a pratice before planting to increase the tolerance to water stress.O efeito do estresse hídrico é dependente da presença de luz em sementes de rabanete. O efeito da peletização com grafite em pó foi analisado. Luz branca e vermelho-extremo são filtradas pelo grafite aumentando parcialmente a tolerância ao estresse hídrico de -0,77MPa em sementes peletizadas. Embora a luz vermelha também iniba a germinação em condições de estresse a peletização não teve efeito. Nós propomos a peletização de sementes de Raphanus saivus L. cv. redondo gigante como uma prática antes do plantio para aumentar a tolerância ao estresse hídrico.

  3. Climatic control on the growth of gigantic gypsum crystals within hypogenic caves (Naica mine, Mexico)?

    Science.gov (United States)

    Garofalo, Paolo S.; Fricker, Mattias B.; Günther, Detlef; Forti, Paolo; Mercuri, Anna-Maria; Loreti, Mara; Capaccioni, Bruno

    2010-01-01

    Three hypogenic caves within the Naica mine of Mexico ( Cueva de los Cristales — CLC, Ojo de la Reina — OR, and Cueva de las Velas — CLV) host spectacular gypsum crystals up to 11 m in length. These caves are close to another shallow cave of the area ( Cueva de las Espadas — CLE), with which they cover a 160 m-deep vertical section of the local drainage basin. Similar to other hypogenic caves, all these caves lack a direct connection with the land surface and should be unrelated with climate. A record of multi-technique fluid inclusion data and pollen spectra from cave and mine gypsum indicates surprisingly that climatic changes occurring at Naica could have controlled fluid composition in these caves, and hence crystal growth. Microthermometry and LA-ICP-Mass Spectrometry of fluid inclusions indicate that the shallow, chemically peculiar, saline fluid (up to 7.7 eq. wt.%NaCl) of CLE could have formed from evaporation, during a dry and hot climatic period. The fluid of the deep caves was instead of low salinity (˜ 3.5 eq. wt.% NaCl) and chemically homogeneous, and was poorly affected by evaporation. We propose that mixing of these two fluids, generated at different depths of the Naica drainage basin, determined the stable supersaturation conditions for the gigantic gypsum crystals to grow. Fluid mixing was controlled by the hydraulic communication between CLE and the other deep caves, and must have taken place during cycles of warm-dry and fresh-wet climatic periods, which are known to have occurred in the region. Pollen grains from a 35 ka-old gypsum crystal of CLC corresponds to a fairly homogenous catchment basin made of a mixed broadleaf wet forest, which suggests precipitation during a fresh-wet climatic period and confirms our interpretation of the fluid inclusion data. The unusual combination of geological and geochemical factors of Naica suggests that other hypogenic caves found elsewhere may not host similar crystals. However, this work shows that

  4. Paraganglioma pré-aórtico gigante Giant preaortic paraganglioma

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    Sergio Renato Pais Costa

    2008-12-01

    Full Text Available INTRODUÇÃO: O paraganglioma é um tumor neuroendócrino raro que ocorre mais frequentemente em adultos jovens. Geralmente produz catecolaminas acarretando síndrome adrenérgica. No entanto, muito raramente, quando não-funcionante seus sintomas são mais frequentemente associados à massa abdominal ou mesmo dor. Nessas circunstâncias costumam representar diagnóstico difícil sendo confundidos com os sarcomas de retroperitônio. RELATO DO CASO: Paraganglioma pré-aórtico gigante não-funcionante em paciente com níveis baixos de catecolaminas (sérico e urinário. O diagnóstico pré-operatório foi dado por tomografia computadorizada, onde foi observada massa sólida, hipervascular com calcificações e área cística central. O paciente foi submetido à ressecção cirúrgica da massa com boa evolução pós-operatória. Um ano após a operação, o doente encontra-se vivo sem recidiva tumoral. CONCLUSÃO: Em que pese a raridade o paraganglioma pré-aortico não-funcionante deve ser lembrado com diagnóstico diferencial com os sarcomas de retroperitônio. Seu tratamento é cirúrgico e apresenta bom prognóstico.RACIONAL: Paraganglioma is a rare neuroendocrine tumor which often diagnosed in the young adult. Generally, paraganglioma produces catecholamines causing adrenergic syndrome. However, more rarely when tumor is nonfunctioning, their symptoms are more associated with an abdominal mass or even pain. In these circumstances, paraganglioma present a difficult diagnosis confounding with retroperitoneal sarcomas. CASE REPORT: The authors present a case of nonfunctioning giant preaortic paraganglioma. This patient had low levels of catecholamines (both seric and urinary. The preoperative diagnosis was done by means computed tomography. This lesion presented as well-vascularized tumor with calcifications and necrotic central area. The patient underwent a surgical resection with good postoperative outcome. To date, one year after surgical

  5. Gigantic landslides versus glacial deposits: on origin of large hummock deposits in Alai Valley, Northern Pamir

    Science.gov (United States)

    Reznichenko, Natalya

    2015-04-01

    As glaciers are sensitive to local climate, their moraines position and ages are used to infer past climates and glacier dynamics. These chronologies are only valid if all dated moraines are formed as the result of climatically driven advance and subsequent retreat. Hence, any accurate palaeoenvironmental reconstruction requires thorough identification of the landform genesis by complex approach including geomorphological, sedimentological and structural landform investigation. Here are presented the implication of such approach for the reconstruction of the mega-hummocky deposits formation both of glacial and landslide origin in the glaciated Alai Valley of the Northern Pamir with further discussion on these and similar deposits validity for palaeoclimatic reconstructions. The Tibetan Plateau valleys are the largest glaciated regions beyond the ice sheets with high potential to provide the best geological record of glacial chronologies and, however, with higher probabilities of the numerous rock avalanche deposits including those that were initially considered of glacial origin (Hewitt, 1999). The Alai Valley is the largest intermountain depression in the upper reaches of the Amudarja River basin that has captured numerous unidentified extensive hummocky deposits descending from the Zaalai Range of Northern Pamir, covering area in more than 800 km2. Such vast hummocky deposits are usually could be formed either: 1) glacially by rapid glacial retreat due to the climate signal or triggered a-climatically glacial changes, such as glacial surge or landslide impact, or 2) during the landslide emplacement. Combination of sediment tests on agglomerates forming only in rock avalanche material (Reznichenko et al., 2012) and detailed geomorphological and sedimentological descriptions of these deposits allowed reconstructing the glacial deposition in the Koman and Lenin glacial catchments with identification of two gigantic rock avalanches and their relation to this glacial

  6. Arteritis de células gigantes (Arteritis temporal Utilidad del Eco-Doppler Color en el diagnóstico

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    Hugo Tarigo

    2016-09-01

    El objetivo de la presente comunicación es reafirmar la utilidad y valor de este método diagnóstico, subutilizado en nuestra práctica clínica, en pacientes con planteo de arteritis de células gigantes.

  7. Etiopatogenia de la arteritis de células gigantes Etiopathogenesis of giant cell arteritis

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    J.M. Casas

    2003-04-01

    Full Text Available La arteritis de células gigantes es una vasculitis que afecta a arterias de diámetro medio y ancho, preferentemente aquellas del arco aórtico con distribución extracraneal, pero también la aorta y otras de sus ramas mayores. Se caracteriza por la presencia de infiltrados inflamatorios mononucleares en la proximidad de la lámina elástica interna constituidos por linfocitos y macrófagos, que en aproximadamente algo más del 50% de los casos contienen células gigantes multinucleadas. La morbilidad asociada a esta enfermedad se relaciona con fenómenos de isquemia distales a la estenosis luminal de las arterias inflamadas y en menor medida con la formación de aneurismas por el debilitamiento de la pared arterial. De etiología desconocida, su patogenia es inmune a través de la migración y localización de células T productoras de γ-INF en la capa adventicia de las arterias inflamadas, suponiéndose que éste es el lugar del estímulo inmune por un antígeno aún no identificado. El reclutamiento y activación de macrófagos por esta citocina constituye uno de los puntos más importantes de su patogenia. La destrucción por éstos del tejido elástico arterial es un fenómeno relevante, así como la producción de otros factores promotores de neoangiogénesis y proliferación de la neoíntima, responsable a través de la obliteración de la luz, de las manifestaciones isquémicas de la enfermedad. El proceso se acompaña de una importante repercusión sistémica caracterizada por una fuerte reacción de fase aguda y síntomas generales de enfermedad poco específicos. Por otra parte, un importante porcentaje de los pacientes presentan un cuadro de polimialgia reumática, entidad en histórica y controvertida relación con esta arteritis. En los últimos años se han producido importantes aportaciones al conocimiento de los mecanismos inmunes implicados en su patogenia.Giant cell arteritis is a vasculitis of large and medium size

  8. The role of the seed coat in the light sensivity in Raphanus sativus L. cv. redondo gigante seeds O papel do tegumento na sensibilidade à luz em sementes de Raphanus sativus L. cv. redondo gigante

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    Maura Lúcia Costa Gonçalves

    1997-07-01

    Full Text Available The role of the seed coat in the light sensitivity of seeds of Raphanus sativus L. cv. redondo gigante was analysed by germination tests of intact and naked seeds. Far-red light caused high inhibition of seed germination, while under white and red lights low inhibition was found. Naked seeds presented no light sensitivity with high percentage germination under light and darkness. However, incubation of naked seeds in -0.6MPa polyethylene glycol solution resulted in light inhibition as observed in intact seeds. The analysis of the seed coat transmitted light indicated that the filtered light presented the same photoequilibrium of phytochrome when compared to the white light, with a decrease of only 33% in the light irradiance which reaches the embryo.O papel do tegumento sobre a sensibilidade à luz em sementes de Raphanus sativus L. cv. redondo gigante foi analisado por testes de germinação de sementes intactas e nuas. A luz vermelho-extremo inibiu fortemente a germinação, enquanto as luzes branca e vermelha apresentaram baixa inibição. Por outro lado, sementes nuas não apresentaram sensibilidade à luz, com alta porcentagem de germinação tanto na luz como no escuro. Entretanto, a incubação das sementes nuas em condições de estresse em solução de polietilenoglicol a -0,6MPa, resultou em inibição na luz, como observadas em sementes intactas. A análise da luz transmitida pelo tegumento das sementes indicou que a luz filtrada apresenta o mesmo fotoequilíbrio teórico do fitocromo obtido na luz branca, com um decréscimo em apenas 33% da irradiância que atinge o embrião.

  9. Liderazgo, la competencia esencial que transformó una empresa colombiana en un gigante internacional : el caso de Cementos Argos

    Directory of Open Access Journals (Sweden)

    Héctor Ochoa Díaz, Ph.D.

    2011-09-01

    Full Text Available Cementos Argos ha sido catalogado como uno de los gigantes de la industria cementera colombiana por su gran capacidad de consolidación en el mercado nacional y sus estrategias de internacionalización poco convencionales. Esta investigación documenta la experiencia internacional de Argos bajo la perspectiva de las teorías de internacionalización de mayor aceptación en la literatura internacional, haciendo uso del enfoque metodológico de los estudios de caso. Como resultado se encontró que las estrategias de fidelización, aunadas al rediseño organizacional resultado del liderazgo de la alta gerencia, han sido herramientas vitales para asegurar el crecimiento de la compañía en los mercados local y externo.

  10. LIDERAZGO, LA COMPETENCIA ESENCIAL QUE TRANSFORMÓ UNA EMPRESA COLOMBIANA EN UN GIGANTE INTERNACIONAL: EL CASO DE CEMENTOS ARGOS

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    HÉCTOR OCHOA DÍAZ

    2011-01-01

    Full Text Available Cementos Argos ha sido catalogado como uno de los gigantes de la industria cementera colombiana por su gran capacidad de consolidación en el mercado nacional y sus estrategias de internacionalización poco convencionales. Esta investigación documenta la experiencia internacional de Argos bajo la perspectiva de las teorías de internacionalización de mayor aceptación en laliteratura internacional, haciendo uso del enfoque metodológico de los estudios de caso. Como resultado se encontró que las estrategias de fidelización,aunadas al rediseño organizacional resultado del liderazgo de la alta gerencia, han sido herramientas vitales para asegurar el crecimiento de la compañía en los mercados local y externo.

  11. Granuloma reparador de células gigantes: relato de cinco casos Giant cell reparative granuloma: report of five cases

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    Martin Torriani

    2001-06-01

    Full Text Available O granuloma reparador de células gigantes é lesão óssea rara, correspondendo a cerca de 7% de todos os tumores ósseos benignos da mandíbula, com maior incidência no sexo feminino. Embora seja considerada resposta a um trauma, este antecedente nem sempre está presente. O aspecto radiológico característico é de lesão lítica, uni ou multiloculada, com afilamento da cortical, podendo apresentar calcificações no seu interior. Neste trabalho relatamos os aspectos clínicos e radiológicos de cinco casos de granuloma reparador de células gigantes envolvendo a mandíbula e o maxilar, e as principais características que permitem o diagnóstico diferencial com outras lesões fibro-ósseas que acometem a face.Giant cell reparative granuloma is an uncommon bone lesion accounting for slightly less than 7% of all benign tumors of the jaw and affecting predominantly females. It probably represents a reparative reaction to a traumatic injury, although history of trauma is not always confirmed. The characteristic radiological feature is a uni- or multilocular lytic bone defect eroding the bone cortical and occasionally presenting with calcifications within the lesion. We report the most important clinical and radiological features observed in five patients with giant cell reparative granuloma involving the mandible and the maxillae and discuss the main aspects for the differential diagnosis with other fibro-osseous lesions that affect the facial bones.

  12. On the shoulders of giants: Harvey Cushing's experience with acromegaly and gigantism at the Johns Hopkins Hospital, 1896-1912.

    Science.gov (United States)

    Pendleton, Courtney; Adams, Hadie; Salvatori, Roberto; Wand, Gary; Quiñones-Hinojosa, Alfredo

    2011-03-01

    A review of Dr. Cushing's surgical cases at Johns Hopkins Hospital revealed new information about his early operative experience with acromegaly. Although in 1912 Cushing published selective case studies regarding this work, a review of all his operations for acromegaly during his early years has never been reported. We uncovered 37 patients who Cushing treated with surgical intervention directed at the pituitary gland. Of these, nine patients who presented with symptoms of acromegaly, and one with symptoms of gigantism were selected for further review. Two patients underwent transfrontal 'omega incision' approaches, and the remaining eight underwent transsphenoidal approaches. Of the 10 patients, 6 were male. The mean age was 38.0 years. The mean hospital stay was 39.4 days. There was one inpatient death during primary interventions (10%) and three patients were deceased at the time of last follow-up (33%). The mean time to death, calculated from the date of the primary surgical intervention, and including inpatient and outpatient deaths, was 11.3 months. The mean time to last follow-up, calculated from the day of discharge, was 59.3 months. At the time of last follow-up, two patients reported resolution of headache; four patients reported continued visual deficits, and two patients reported ongoing changes in mental status. This review analyzes the outcomes for 10 patients who underwent surgical intervention for acromegaly or gigantism, and offers an explanation for Cushing's transition from the transfrontal "omega incision" to the transsphenoidal approach while practicing at the Johns Hopkins Hospital.

  13. Aggressive tumor growth and clinical evolution in a patient with X-linked acro-gigantism syndrome.

    Science.gov (United States)

    Naves, Luciana A; Daly, Adrian F; Dias, Luiz Augusto; Yuan, Bo; Zakir, Juliano Coelho Oliveira; Barra, Gustavo Barcellos; Palmeira, Leonor; Villa, Chiara; Trivellin, Giampaolo; Júnior, Armindo Jreige; Neto, Florêncio Figueiredo Cavalcante; Liu, Pengfei; Pellegata, Natalia S; Stratakis, Constantine A; Lupski, James R; Beckers, Albert

    2016-02-01

    X-linked acro-gigantism (X-LAG) syndrome is a newly described disease caused by microduplications on chromosome Xq26.3 leading to copy number gain of GPR101. We describe the clinical progress of a sporadic male X-LAG syndrome patient with an Xq26.3 microduplication, highlighting the aggressive natural history of pituitary tumor growth in the absence of treatment. The patient first presented elsewhere aged 5 years 8 months with a history of excessive growth for >2 years. His height was 163 cm, his weight was 36 kg, and he had markedly elevated GH and IGF-1. MRI showed a non-invasive sellar mass measuring 32.5 × 23.9 × 29.1 mm. Treatment was declined and the family was lost to follow-up. At the age of 10 years and 7 months, he presented again with headaches, seizures, and visual disturbance. His height had increased to 197 cm. MRI showed an invasive mass measuring 56.2 × 58.1 × 45.0 mm, with compression of optic chiasma, bilateral cavernous sinus invasion, and hydrocephalus. His thyrotrope, corticotrope, and gonadotrope axes were deficient. Surgery, somatostatin analogs, and cabergoline did not control vertical growth and pegvisomant was added, although vertical growth continues (currently 207 cm at 11 years 7 months of age). X-LAG syndrome is a new genomic disorder in which early-onset pituitary tumorigenesis can lead to marked overgrowth and gigantism. This case illustrates the aggressive nature of tumor evolution and the challenging clinical management in X-LAG syndrome.

  14. Divertículo gigante de colon: presentación de un caso Giant colonic diverticulum: case report

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    Ezequiel Ochoa

    2008-12-01

    Full Text Available El divertículo gigante de colon (DGC es una rara complicación de la enfermedad diverticular. Se considera divertículo gigante cuando su diámetro supera los 4 cm. Descrito por primera vez en la literatura francesa en el año 1946, se han publicado hasta la fecha 155 casos. Nuestro paciente, de 59 años, refirió clínica de dolor abdominal leve de 4 meses de evolución. Se le solicitó un estudio de colon por enema, el que reveló una formación sacular de 15 cm en colon sigmoideo, de contenido aéreo y cuello corto, a través del cual se opacificó la cavidad con la sustancia baritada, confirmando el diagnóstico de DGC. Al paciente se le realizó, además, tomografía computada y resonancia magnética. El diagnóstico se confirmó con cirugía y estudio histopatológico. Se practicó una resección sigmoidea con DGC y anastomosis colorrectal lateroterminal. El estudio anatomopatológico informó DGC tipo II.Giant colonic diverticulum is a rare diverticular disease complication. It is considered giant when its diameter is longer than 4 cms. It was reported the first time by french authors in 1946 and there is 155 cases reported in world literature. Our patient aged 59 years old, referred four month of abdominal pain. A barium enema was made showing a sigmoid cavity with air and fill of barium contrast with short neck continuing with the colon lumen. It was also studied with CT and MRI. The diagnosis was confirmed by surgery and histopathologic exam. The pathologic report informed giant colonic diverticulum type II.

  15. Primer caso de Síndrome Prune Belly-Like en una ternera de raza holstein con quistes hepáticos serosos (First case of Prune Belly-Like Syndrome in a Holstein calf with hepatic serous cysts

    Directory of Open Access Journals (Sweden)

    Astiz Blanco S.:

    Full Text Available Resumen Un ternero de raza holstein y criptorquidia bilateral. Hay distintas presentaba un abdomen pendulante y con hipótesis que tratan de explicar la una pared abdominal muy fina. Las etiología; laembriológica (defecto en el vísceras abdominales se encontraban desarrollo de la placa mesodérmica, la desplazadas caudoventralmente, teoría teratológica y, finalmente, la evidenciándose dorsalmente la protrusión genética (alteraciones cromosómicas que del riñón izquierdo. El animal fue podrían producir la atresia uretral con eutanasiado y en la necropsia los uropatía obstructiva prenanatal. Este músculos abdominales parecían reducirse hecho produciría la distensión de la vejiga a una simple fascia, mientras que el y la lesión del tracto urinario, impidiendo hígado presentaba numerosos quistes el descenso testicular. Las lesiones serosos de gran tamaño pero ya vacíos en musculares podrían estar causadas bien ese momento y que no afectaba a otras directamente por un defecto en el vísceras. El animal no presentaba ascitis. desarrollo de la placa mesodérmica, bien El estudio anatomopatológico de los indirectamente por la distensión y fallo músculos M.transversus abdominis, vascular. Además, hay casos descritos M.internal abdominal oblique, M.rectus similares a este síndrome (prune belly-abdominis y M.external abdominal like en el cual aparece sólo parte de la evidenció unas pequeñas fibras triada de signos. Este es el caso de dos musculares, probablemente debido a un bebés con grandes quistes desarrollo incompleto o a una atrofia intraabdominales prenatales reabsorbidos muscular. antes del parto, que dejaron como secuela En medicina humana hay un una fina pared abdominal característica

  16. Occurrence of gigantic biogenic magnetite during the Paleocene-Eocene Thermal Maximum

    Science.gov (United States)

    Schumann, D.; Raub, T. D.; Kopp, R. E.; Guerquin-Kern, J. L.; Wu, T. D.; Rouiller, I.; Smirnov, A. V.; Sears, S. K.; Lücken, U.; Tikoo, S. M.; Hesse, R.; Kirschvink, J. L.; Vali, H.

    2009-04-01

    et al. 2008] to other PETM locations of the Atlantic margin and to a possible modern analog environment. High surface productivity with low-organic carbon density sediments and meter-scale sedimentary suboxic zones are provided by tropical shelves fed by energetic river systems, such as the Amazon. We inverstigated several magnetic extracts of samples taken from the meter-scale suboxic zones of the Amazone delta system. Sluijs A, Brinkhuis H, Schouten S, Bohaty SM, John CM, Zachos JC, Reichart GJ, Damste JSS, Crouch EM, Dickens GR. 2007. Environmental precursors to rapid light carbon injection at the Palaeocene/Eocene boundary. Nature 450:1218-1221. Kopp RE, Raub TD, Schumann D, Vali H, Smirnov AV, Kirschvink JL 2007. Magnetofossil spike during the Paleocene-Eocene thermal maximum: Ferromagnetic resonance, rock magnetic, and electron microscopy evidence from Ancora, New Jersey, United States. Paleoceanography, doi:10.1029/2007pa001473. Lipper PC, Zachos JC 2007. A biogenic origin for anomalous fine-grained magnetic material at the Paleocone-Eocene booundary at Wilson Lake, New Jesery. Paleoceanography, doi:10.1029/2007pa001471. Schumann D, Raub TD, Kopp RE, Guerquin-Kern JL, Wu TD, Rouiller I, Smirnov AV, Sears K, Lücken U, Tikoo SM, Hesse R, Kirschvink JL, Vali H 2008. Gigantism in unique biogenic magnetite at the Paleocene-Eocene Thermal Maximum. PNAS, 105:17648-17653.

  17. Tratamento operatório das bolhas pulmonares gigantes Surgical treatment of giant emphysematous lung bullae

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    Marcio Botter

    2007-06-01

    Full Text Available OBJETIVOS: A escassez de publicações nacionais a respeito desta doença no Brasil nos motivou a realizar o presente trabalho, cujos objetivos são descrever a evolução histórica e analisar os resultados do tratamento operatório das bolhas enfisematosas gigantes na Santa Casa de São Paulo. MÉTODOS: Avaliamos retrospectivamente, entre janeiro de 1979 a junho de 2005, os prontuários de 83 doentes submetidos a uma entre quatro modalidades operatórias: bulectomia por toracotomia, bulectomia por cirurgia torácica videoassistida (CTVA, drenagem de bolha por CTVA e drenagem de bolha com anestesia local, totalizando 92 operações. Os parâmetros analisados foram tempo de internação, complicações pós-operatórias, mortalidade perioperatória e tardia, além de parâmetros clínicos e funcionais pré e pós-operatórios. RESULTADOS: A morbidade foi de 40,2% e mortalidade pós-operatória precoce, de 4,3%. As complicações pós-operatórias tiveram relação com os antecedentes mórbidos dos doentes. Fatores como enfisema pulmonar difuso, múltiplas bolhas e idade não influenciaram nas complicações precoces. Houve melhora da sintomatologia e dos resultados funcionais em 94,5% dos doentes. Não houve recidiva das bolhas operadas. A mortalidade cinco anos após a operação foi de 18,3% e decorreu, principalmente, da progressão clínica do enfisema pulmonar difuso. CONCLUSÃO: Diversas modalidades operatórias foram realizadas para tratar bolhas pulmonares enfisematosas, desde a bulectomia por toracotomia, na fase inicial até a drenagem de bolha com anestesia local e talcagem, o método que preferencialmente realizamos nos dias atuais. Independente do método utilizado, entretanto, não obstante a morbidade relativamente elevada, os resultados pós-operatórios são bastante favoráveis, com baixa mortalidade e incontestável melhora clínico-funcional dos doentes operados.OBJECTIVE: Lack of Brazilian publications regarding this disease

  18. Análise da expressão gênica no tumor ósseo de células gigantes

    OpenAIRE

    Babeto, Erica [UNESP

    2011-01-01

    O tumor ósseo de células gigantes (TCG) é um tumor benigno, que causa destruição osteolítica, com comportamento biológico incerto e com características particulares como um elevado número de células gigantes multinucleadas e comportamento agressivo. A recorrência local do TCG é freqüentemente observada em 20 a 50% dos casos. Mais agravante que a recorrência, é o fato de que após a recidiva, o paciente muitas vezes também apresenta metástases em outros órgãos, principalmente no pulmão. Dessa f...

  19. Ultrafast Gigantic Photo-Response in Charge-Ordered Organic Salt (EDO-TTF)2PF6 on 10-fs time scales

    Science.gov (United States)

    Itatani, J.; Rini, M.; Cavalleri, A.; Onda, K.; Ishikawa, T.; Ogihara, S.; Koshihara, S.; Shao, X. F.; Nakano, Y.; Yamochi, H.; Saito, G.; Schoenlein, R. W.

    The initial dynamics of photo-induced phase transition in charge-ordered organic salt (EDO-TTF)2PF6 was investigated using 10-fs near-infrared laser pulses. We observed sub-20-fs gigantic photo-responses (|∆R/R|>100%) due to intra-molecular vibration and a clear signature of a structural bottleneck (~50 fs) for the first time.

  20. What Lies Beneath: Sub-Articular Long Bone Shape Scaling in Eutherian Mammals and Saurischian Dinosaurs Suggests Different Locomotor Adaptations for Gigantism

    OpenAIRE

    2013-01-01

    Eutherian mammals and saurischian dinosaurs both evolved lineages of huge terrestrial herbivores. Although significantly more saurischian dinosaurs were giants than eutherians, the long bones of both taxa scale similarly and suggest that locomotion was dynamically similar. However, articular cartilage is thin in eutherian mammals but thick in saurischian dinosaurs, differences that could have contributed to, or limited, how frequently gigantism evolved. Therefore, we tested the hypothesis tha...

  1. Buschke -Loewenstein tumor: identification of HPV type 6 and 11 Condiloma acuminado gigante de Buschke-Lowenstein: identificação dos HPV 6 e 11

    OpenAIRE

    Juliana Casagrande Tavoloni Braga; Sidney Roberto Nadal; Monica Stiepcich; Valéria Maria de Souza Framil; Helena Muller

    2012-01-01

    The authors report a case of exuberant giant condyloma acuminatum of Buschke-Loewenstein in a male patient, slow-growing, progressive and with locally destructive behavior in the inguinal, body of the penis, scrotum, perineal and perianal regions. After surgery he showed no signs of recurrence in 20 months of follow-up. The identification of HPV types 6 and 11 was performed using in situ hybridization.Os autores relatam um caso exuberante de condiloma acuminado gigante de Buschke-Lowenstein, ...

  2. Coexisting diseases modifying each other’s presentation - lack of growth failure in Turner syndrome due to the associated pituitary gigantism

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    Dragović Tamara

    2016-01-01

    Full Text Available Introduction. Turner syndrome presents with one of the most frequent chromosomal aberrations in female, typically presented with growth retardation, ovarian insufficiency, facial dysmorphism, and numerous other somatic stigmata. Gigantism is an extremely rare condition resulting from an excessive growth hormone (GH secretion that occurs during childhood before the fusion of epiphyseal growth plates. The major clinical feature of gigantism is growth acceleration, although these patients also suffer from hypogonadism and soft tissue hypertrophy. Case report. We presented a girl with mosaic Turner syndrome, delayed puberty and normal linear growth for the sex and age, due to the simultaneous GH hypersecretion by pituitary tumor. In the presented case all the typical phenotypic stigmata related to Turner syndrome were missing. Due to excessive pituitary GH secretion during the period while the epiphyseal growth plates of the long bones are still open, characteristic stagnation in longitudinal growth has not been demonstrated. The patient presented with delayed puberty and primary amenorrhea along with a sudden appearance of clinical signs of hypersomatotropinism, which were the reasons for seeking medical help at the age of 16. Conclusion. Physical examination of children presenting with delayed puberty but without growth arrest must include an overall hormonal and genetic testing even in the cases when typical clinical presentations of genetic disorder are absent. To the best of our knowledge, this is the first reported case of simultaneous presence of Turner syndrome and gigantism in the literature.

  3. Seesaw nystagmus caused by giant pituitary adenoma: case report Nistagmo em gangorra causado por adenoma pituitário gigante: relato de caso

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    Frederico Castelo Moura

    2006-03-01

    Full Text Available Giant pituitary adenomas are uncommonly large tumors, greater than 4 cm in size that can produces endocrine symptoms, visual loss and cranial nerve palsies. We report the rare occurrence of seesaw nystagmus as the presenting sign of giant pituitary adenoma. A 50-year-old man presented with headache associated with visual loss and seesaw nystagmus. Perimetry revealed bitemporal hemianopia and magnetic resonance imaging showed a giant pituitary adenoma. After surgery, nystagmus disappeared. Our case is relevant in understanding its pathogenesis since it documents seesaw nystagmus in a patient bitemporal hemianopia due to a large tumor but without mesencephalic compression.Adenoma pituitário gigante é um tumor incomum, maior que 4 cm que produz sintomas endócrinos, perda visual e paralisia de nervos cranianos. Relatamos um caso de nistagmo em gangorra como sinal de apresentação de adenoma pituitário gigante. Um paciente de 50 anos, masculino, apresentava cefaléia, perda visual e nistagmo em gangorra. A perimetria revelou hemianopsia bitemporal e a imagem por ressonância magnética demonstrou um adenoma pituitário gigante. Após a cirurgia, o nistagmo desapareceu. Nosso caso é importante na compreensão da fisiopatogenia do nistagmo em gangorra, pois documenta sua ocorrência em paciente com hemianopsia bitemporal decorrente de tumor hipofisário sem compressão mesencefálica.

  4. Detección de portadores asintomáticos de quistes hidatídicos: aumento de la especificidad del ensayo inmunoenzimático Detection of asymptomatic hydatic cysts carriers by an enzymatic immunoassay

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    E. A. Coltorti

    1990-08-01

    Full Text Available Una de las actividades que realizan los programas de control de hidatidosis causada por Echinococcus granulosus en la República Argentina es la búsqueda de portadores asintomáticos de quistes hidatídicos entre la población general que habita las áreas de riesgo, mediante un ensayo inmunoenzimático (EIE con antígeno de liquido hidatídico total (EIE-ALHT que selecciona los posibles portadores. En base a la experiencia recogida se ha observado que dependiendo de la prevalencia del área, entre el 10% y el 30% de las personas seleccionadas por el EIE con valores de densidad óptica (DO > DO + 4S no presentan imagenes compatibles con quistes hidatídicos. El propósito del estudio fue mejorar la especificidad de la prueba. Con ese fin, se evaluó la influencia de la modificación de la oferta antigénica y el efecto de la absorción de los anticuerpos anti-componentes séricos ovinos y anti-fosforilcolina de los sueros en estudios. 114 sueros no hidatídicos seleccionados por su alto nivel de reacciones cruzadas en EIE-ALHT y 118 sueros hidatídicos se estudiaron frente a 4 fracciones antigénicas de liquido hidatídico ovino. El EIE que empleo la fracción antigénica S2B conjuntamente con la absorción previa de los sueros (EIE-S2B/A fue el sistema que mejor discriminó los sueros hidatídicos de los no hidatídicos con altos niveles de anticuerpos no relacionados con la presencia de quistes. Se propone el empleo del sistema EIE-S2B/A para la búsqueda a campo de portadores asintomáticos de quistes hidatídicos en reemplazo del EIE-ALHT actualmente en uso. Las 4 fracciones antigénicas fueron analizadas por doble difusión y SDS-PAGE. La fracción S2B se caracterizó como enriquecida en componentes parasitarios de menos de 30 Kd entre los cuales se encontrarian el antígeno B y subunidades o fragmentos del antígeno 5.An enzymoimmunoassay (EIE as a screening test to select potential asymptomatic cyst carriers among the general population

  5. Tumor fusocelular hialinizante con rosetas gigantes: Reporte de un caso Hyalinizing spindle cell tumor with giant rosettes: Case report

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    Ernesto García Ayala

    2010-12-01

    Full Text Available Introducción: El tumor fusocelular hialinizante con rosetas gigantes es una neoplasia constituida por dos componentes histológicos, uno celular con elementos fusiformes, y el segundo representado por islas bien delimitadas casi acelulares, llenas de material hialino, rodeadas de células redondas u ovales, las cuales muestran un perfil inmunohistoquímico inusual, e histogénesis incierta. Objetivo: Instruir a los patólogos y clínicos sobre este tumor, su forma de presentación y diagnósticos diferenciales. Metodología y resultados: Se presenta el caso de una mujer de 42 años con masa ubicada en región inguinal, de crecimiento progresivo (1 año, que se reseca quirúrgicamente anatomía patológica informó un tumor fusocelular hialinizante con rosetas gigantes, según hallazgos morfológicos e inmuno histoquímicos, en correlación con su localización y cuadro clínico. Conclusión: Se hace necesario ampliar el conocimiento sobre esta entidad y de esta forma obtener una adecuada evaluación de sus criterios pronósticos histológicos, comportamiento clínico y tratamiento. Salud UIS 2010; 42: 282-286Introduction: The hyalinizing spindle cell tumor with giant rosettes is a neoplasia characterized by both histologic components, one of which is cellular, with spindle-shaped elements and the second represented by well defined almost acellular islands filled with hyaline material surrounded by round to oval cells, which shows an unusual immunohistochemical profile and uncertain histogenesis. Objective: Educate pathologists and clinicians about this tumor, its presentation and differential diagnosis. Methods and results: A case of a 42 year old woman with a mass located in the inguinal region, with progressive growth (1 year, surgically resected and histopathology reported as Hyalinizing spindle cell tumor with giant rosettes according to morphological, immunohistochemical findings correlates with its location and clinical. Conclusion: It is

  6. Análise química do bambu-gigante (Dendrocalamus giganteus Wall. ex Munro em diferentes idades

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    Nelson Potenciano Marinho

    2012-06-01

    Full Text Available http://dx.doi.org/10.5902/198050985749O bambu é uma planta monocotiledônea de origem tropical, de rápido crescimento, sendo considerado um importante regenerador ambiental devido ao seu sistema radicular. O Dendrocalamus giganteus é popularmente conhecido por bambu-gigante, sendo uma espécie entouceirante de grande porte, cujos colmos podem variar de 24 a 40 metros de altura, com diâmetros entre 10 e 20 cm. Esse trabalho teve como objetivo analisar quimicamente os colmos do bambu-gigante visando fornecer informações sobre a sua composição química nas idades de 2 a 6 anos. Os colmos do bambu foram coletados na área Experimental Agrícola do Departamento de Engenharia Mecânica da UNESP-Bauru, onde é realizado o manejo sistemático de diversas espécies de bambu para fins de pesquisas e divulgação dessa planta. Foram retiradas amostras da base entre bambus com idade de 2 a 6 anos de uma mesma touceira, totalizando 5 amostras, com 2 metros de altura cada, colhidas na lua minguante no mês de março. As análises químicas foram feitas com os entrenós, utilizando as normas e procedimentos da TAPPI. A porcentagem média de extrativos em água quente, extrativos em água fria, extrativos totais e teor de cinzas não apresentaram relação direta com a idade. A maior porcentagem de extrativos em água quente, com valor de 12,04%, extrativos em água fria, com 10,25%, e extrativos totais, com 12,91%, foi observada aos 2 anos de idade. A maior porcentagem de cinzas foi obtida aos três anos, com valores de 1,09%. O teor médio de extrativos em NaOH diminui de 25,72% aos dois anos para 20,17% aos seis anos de idade. O mesmo comportamento foi observado para os extrativos em etanol tolueno, diminuindo de 10,91% para 4,61%. O teor médio de lignina não sofreu influência da idade, variando de 22,66 a 24,11%.

  7. Herbivory and body size: allometries of diet quality and gastrointestinal physiology, and implications for herbivore ecology and dinosaur gigantism.

    Science.gov (United States)

    Clauss, Marcus; Steuer, Patrick; Müller, Dennis W H; Codron, Daryl; Hummel, Jürgen

    2013-01-01

    Digestive physiology has played a prominent role in explanations for terrestrial herbivore body size evolution and size-driven diversification and niche differentiation. This is based on the association of increasing body mass (BM) with diets of lower quality, and with putative mechanisms by which a higher BM could translate into a higher digestive efficiency. Such concepts, however, often do not match empirical data. Here, we review concepts and data on terrestrial herbivore BM, diet quality, digestive physiology and metabolism, and in doing so give examples for problems in using allometric analyses and extrapolations. A digestive advantage of larger BM is not corroborated by conceptual or empirical approaches. We suggest that explanatory models should shift from physiological to ecological scenarios based on the association of forage quality and biomass availability, and the association between BM and feeding selectivity. These associations mostly (but not exclusively) allow large herbivores to use low quality forage only, whereas they allow small herbivores the use of any forage they can physically manage. Examples of small herbivores able to subsist on lower quality diets are rare but exist. We speculate that this could be explained by evolutionary adaptations to the ecological opportunity of selective feeding in smaller animals, rather than by a physiologic or metabolic necessity linked to BM. For gigantic herbivores such as sauropod dinosaurs, other factors than digestive physiology appear more promising candidates to explain evolutionary drives towards extreme BM.

  8. Herbivory and body size: allometries of diet quality and gastrointestinal physiology, and implications for herbivore ecology and dinosaur gigantism.

    Directory of Open Access Journals (Sweden)

    Marcus Clauss

    Full Text Available Digestive physiology has played a prominent role in explanations for terrestrial herbivore body size evolution and size-driven diversification and niche differentiation. This is based on the association of increasing body mass (BM with diets of lower quality, and with putative mechanisms by which a higher BM could translate into a higher digestive efficiency. Such concepts, however, often do not match empirical data. Here, we review concepts and data on terrestrial herbivore BM, diet quality, digestive physiology and metabolism, and in doing so give examples for problems in using allometric analyses and extrapolations. A digestive advantage of larger BM is not corroborated by conceptual or empirical approaches. We suggest that explanatory models should shift from physiological to ecological scenarios based on the association of forage quality and biomass availability, and the association between BM and feeding selectivity. These associations mostly (but not exclusively allow large herbivores to use low quality forage only, whereas they allow small herbivores the use of any forage they can physically manage. Examples of small herbivores able to subsist on lower quality diets are rare but exist. We speculate that this could be explained by evolutionary adaptations to the ecological opportunity of selective feeding in smaller animals, rather than by a physiologic or metabolic necessity linked to BM. For gigantic herbivores such as sauropod dinosaurs, other factors than digestive physiology appear more promising candidates to explain evolutionary drives towards extreme BM.

  9. Dorsal resection of a thoracic hemivertebra in a 4-year-old boy with endochondral gigantism. A case report.

    Science.gov (United States)

    Zarghooni, Kourosh; Sobotrke, Rolf; Schmidt, Heinrich; Rollinghoff, Marc; Siewe, Jan; Eysel, Peer

    2010-10-01

    The authors present what appears to be the first case of congenital kyphosis due to a T12 hemivertebra in a four-year-old boy with endochondral gigantism syndrome of unknown origin. Because of his overgrowth, the patient had severe medical and orthopaedic problems and was almost immobile. Prior to surgery, he experienced a rapidly progressive thoracolumbar kyphosis to 600 (T10-L2). MRI of the brain and spine showed critical protraction of the spinal cord and myelopathy from compression at T12. Single-stage posterior resection of the hemivertebra with spinal shortening and dorsal transpedicular instrumentation of T10-L2 was performed. Although the bone tissue was cartilaginous and dysplastic, 420 (30%) correction was achieved along with decompression of the spinal canal. The patient experienced no neurological impairment post-operatively. At follow-up examination 1.5 year after surgery, the patient's movement disorder had improved markedly and he was able to stand and walk. This very rare case demonstrates that single-stage posterior hemivertebra resection and transpedicular instrumentation for correction of congenital kyphosis can be a safe and effective procedure even in a very challenging case.

  10. Reconstrucción cervical tras resección de neurofibroma solitario gigante con colgajo anterolateral de muslo

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    Mauricio Mendieta-Espinosa

    Full Text Available Los tumores de cabeza y cuello son un grupo heterogéneo; los neurofibromas pueden originarse de cualquier nervio independientemente de su localización, incluyendo nervios periféricos o intracraneales y se dividen en 4 tipos. Los solitarios son tumores confinados, espontáneos y prácticamente sin ninguna manifestación. Anatómicamente, los neurofibromas del cuello son relativamente raros, con un crecimiento lento e indoloro. Presentamos el caso de un paciente varón de 41 años de edad, remitido a nuestra consulta por presentar neurofibroma solitario gigante en la base del lado izquierdo del cuello, de 10 cm de diámetro, con zona central ulcerada y sangrados intermitentes, adherido a planos profundos, de 30 años de evolución y que había sido tratado en 3 ocasiones con resecciones parciales y cubertura con colgajo acromial. Practicamos resección completa de la tumoración y reconstrucción inmediata con colgajo anterolateral de muslo, logrando la mejoría estético-funcional de la zona cervical y sin complicaciones.

  11. Quiste dentígero asociado con un diente ectópico en el seno maxilar: Reporte de un caso y revisión de la literatura Dentigerous cyst associated with an ectopic tooth in the maxillary sinus: A report of one case and review of the literature

    Directory of Open Access Journals (Sweden)

    D. Antunes Freitas

    2011-12-01

    Full Text Available El quiste dentígero o folicular es un quiste odontogénico benigno que se encuentra relacionado con la corona de dientes no erupcionados con mayor porcentaje de incidencia en terceros molares, caninos y dientes supernumerarios; los cuales se pueden hallar en posiciones ectópicas, en el maxilar superior se ubican preferentemente en el seno maxilar. Se reporta caso de un quiste dentígero asociado a un tercer molar superior izquierdo en el seno maxilar en un paciente femenino de 19 años de edad la cual es remitida a la Clínica de Diagnóstico Oral en la Escuela de Odontología Curso de Funorte-Brasil. De igual manera se realizo una revisión bibliográfica de esta entidad patológica, sus características clínicas, tratamiento y pronostico.Dentigerous or follicular cyst is a benign odontogenic cyst is related to the crown of unerupted teeth with the highest percentage of incidence in third molars, canines and supernumerary teeth which can be found in ectopic positions in the upper jaw are located preferably in the maxillary sinus. We report a case of dentigerous cyst associated with a left upper third molar into the maxillary sinus in a female patient 19 years old who is sent to the Oral Diagnosis Clinic at the School of Dentistry Course Funorte-Brazil. In the same way we made a literature review of this pathological entity, their clinical characteristics, treatment and prognosis.

  12. Utilización de Colloss® para el tratamiento de quistes mandibulares: Descripción de una serie clínica The use of lyophilized bovine collagen (Colloss®) for treating mandibular cysts: Description of a clinical series

    OpenAIRE

    J. Arias Gallo; J.M. López-Arcas Calleja; T. González Otero; E. Gómez García; Morán Soto, M.J.

    2007-01-01

    La enucleación de quistes óseos conlleva la aparición de defectos óseos. Se acepta que los cuando son menores de 3 cm. de diámetro y están alejados del reborde alveolar se rellenan de hueso neoformado en unos meses. Por el contrario, defectos óseos mayores no regeneran completamente. "Colloss®" parece ser un interesante material osteoinductivo. Se trata de un complejo liofilizado de las proteínas extracelulares extraídas del hueso bovino diafisario. Contiene fundamentalmente colágeno tipo I y...

  13. Quiste hidatídico hepático complicado con invasión a vena cava inferior y embolización de membranas hidatídicas a aurícula derecha: Caso clínico

    OpenAIRE

    BAHAMONDES S,JUAN C; SANDOVAL M,PABLO; LOSADA M,HÉCTOR; Meriño S,Gustavo; SALMAN A,JUAN; SILVA V,ABELARDO; Mora P,Javier

    2010-01-01

    La hidatidosis es una zoonosis parasitaria, de mayor incidencia en el sur de Chile. Su localización más frecuente es hepática y pulmonar. Sus complicaciones derivan de su crecimiento y afección de estructuras adyacentes o de su ruptura a cavidades. Presentamos un caso de quiste hidatídico hepático complicado, en una paciente que debutó con cuadro de dolor abdominal localizado en hipocondrio derecho producto de una lesión quística hepática con comunicación a vena cava inferior, siendo interven...

  14. Fibrosarcoma gigante de ovario: a propósito de un caso Giant ovarian fibrosacarcoma: apropos of a case

    Directory of Open Access Journals (Sweden)

    Magaly Marion Luna Gozá

    2008-06-01

    Full Text Available Se presenta el caso de una paciente de 62 años de edad, de la raza negra, con antecedentes de enfermedad y aumento de volumen del abdomen de varios años de evolución. Al estudiarlo, no se obtuvieron resultados concluyentes. Después de constatar el gran aumento de volumen del abdomen y de palpar un tumor que lo ocupaba casi totalmente, se le realizaron estudios imagenológicos que no definieron el lugar de procedencia del tumor, y se decidió intervenir quirúrgicamente, ya que por el crecimiento tumoral los síntomas compresivos intraabdominales aumentaban progresivamente. En el acto operatorio se encontró un tumor gigante en el ovario izquierdo, con diámetro transversal de más de 60 cm y peso superior a 12 kg. Se realizó la exéresis del tumor, histerectomía total, anexectomía derecha y omentectomía.The case of a 62-year-old black female patient with past health history and increase of the abdomen volume of some years of evolution is presented. On studying her, no concluding results were attained. After confirming the considerable enlargement of the abdomen and palpating a tumor that occupied it almost totally, imaging studies, which did not define the place of origin of the tumor, were conducted. It was decided to carry out surgery, since the tumoral growth caused a progressive rise of the intraabdominal compressive symptoms. During the operation, it was found a giant tumor of the left ovary, with a transversal diameter of more than 60 cm and a weight over 12 kg. Tumor exeresis, total hysterectomy, right anexectomy and omentectomy were performed.

  15. NOVOS LETRAMENTOS NA CULTURA DIGITAL: O REMIX VEM PRA RUA - O GIGANTE ACORDOU COMO UM HÍBRIDO

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    Rosivaldo Gomes

    2015-07-01

    Full Text Available A utilização da internet, das mídias e redes sociais digitais e de celulares se constituiu como um diferencial importantíssimo no grande movimento social que mexeu com o País e com as visões sobre ele nas manifestações ocorridas em junho de 2013. Essas mídias e redes sociais digitais (YouTube, Flickr, Facebook, Instagram, Twitter, etc. se constituíram como canais de informação, ambientes comunicacionais, pontos de encontro, enfim, em redes e, às vezes, até em comunidades que facilitaram os relacionamentos entre os que estavam conectados e dispostos a se manifestarem de algum modo. Nessa direção, os novos letramentos digitais e o novo ethos como defendido por Lankshear e Knobel (2007 proporcionaram contribuições significativas para o uso das tecnologias digitais de informação e comunicação na propagação dessas manifestações, e, buscando compreender o modo como esses novos letramentos favoreceram isso, neste artigo buscamos, a partir das noções de hibridismo e intercalação (GARCÍA CANCLINI, 2008 [1989]; BAKHTIN, 2002 [1934-5] e  nas discussões de Lankshear e Knobel (2007; 2008 sobre remix e sobre linguagens hipermidiática e híbrido digital (SANTAELLA, 2003; 2004, realizar uma análise qualitativa do remix digita Vem pra rua - O gigante acordou,  no que diz respeito as técnicas de produção e constituição desse gênero na construção de novos significado, considerando o horizonte espacial e temporal (VOLOCHINOV/BAKHTIN, [1926]1976 nos quais foi produzido

  16. In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism.

    Science.gov (United States)

    Salvatori, Roberto; Radian, Serban; Diekmann, Yoan; Iacovazzo, Donato; David, Alessia; Gabrovska, Plamena; Grassi, Giorgia; Bussell, Anna-Marie; Stals, Karen; Weber, Astrid; Quinton, Richard; Crowne, Elizabeth C; Corazzini, Valentina; Metherell, Lou; Kearney, Tara; Du Plessis, Daniel; Sinha, Ajay Kumar; Baborie, Atik; Lecoq, Anne-Lise; Chanson, Philippe; Ansorge, Olaf; Ellard, Sian; Trainer, Peter J; Balding, David; Thomas, Mark G; Korbonits, Márta

    2017-09-01

    Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are associated with pituitary adenoma, acromegaly and gigantism. Identical alleles in unrelated pedigrees could be inherited from a common ancestor or result from recurrent mutation events. Observational, inferential and experimental study, including: AIP mutation testing; reconstruction of 14 AIP-region (8.3 Mbp) haplotypes; coalescent-based approximate Bayesian estimation of the time to most recent common ancestor (tMRCA) of the derived allele; forward population simulations to estimate current number of allele carriers; proposal of mutation mechanism; protein structure predictions; co-immunoprecipitation and cycloheximide chase experiments. Nine European-origin, unrelated c.805_825dup-positive pedigrees (four familial, five sporadic from the UK, USA and France) included 16 affected (nine gigantism/four acromegaly/two non-functioning pituitary adenoma patients and one prospectively diagnosed acromegaly patient) and nine unaffected carriers. All pedigrees shared a 2.79 Mbp haploblock around AIP with additional haploblocks privately shared between subsets of the pedigrees, indicating the existence of an evolutionarily recent common ancestor, the 'English founder', with an estimated median tMRCA of 47 generations (corresponding to 1175 years) with a confidence interval (9-113 generations, equivalent to 225-2825 years). The mutation occurred in a small tandem repeat region predisposed to slipped strand mispairing. The resulting seven amino-acid duplication disrupts interaction with HSP90 and leads to a marked reduction in protein stability. The c.805_825dup allele, originating from a common ancestor, associates with a severe clinical phenotype and a high frequency of gigantism. The mutation is likely to be the result of slipped strand mispairing and affects protein-protein interactions and AIP protein stability. © 2017 The authors.

  17. What lies beneath: sub-articular long bone shape scaling in eutherian mammals and saurischian dinosaurs suggests different locomotor adaptations for gigantism.

    Science.gov (United States)

    Bonnan, Matthew F; Wilhite, D Ray; Masters, Simon L; Yates, Adam M; Gardner, Christine K; Aguiar, Adam

    2013-01-01

    Eutherian mammals and saurischian dinosaurs both evolved lineages of huge terrestrial herbivores. Although significantly more saurischian dinosaurs were giants than eutherians, the long bones of both taxa scale similarly and suggest that locomotion was dynamically similar. However, articular cartilage is thin in eutherian mammals but thick in saurischian dinosaurs, differences that could have contributed to, or limited, how frequently gigantism evolved. Therefore, we tested the hypothesis that sub-articular bone, which supports the articular cartilage, changes shape in different ways between terrestrial mammals and dinosaurs with increasing size. Our sample consisted of giant mammal and reptile taxa (i.e., elephants, rhinos, sauropods) plus erect and non-erect outgroups with thin and thick articular cartilage. Our results show that eutherian mammal sub-articular shape becomes narrow with well-defined surface features as size increases. In contrast, this region in saurischian dinosaurs expands and remains gently convex with increasing size. Similar trends were observed in non-erect outgroup taxa (monotremes, alligators), showing that the trends we report are posture-independent. These differences support our hypothesis that sub-articular shape scales differently between eutherian mammals and saurischian dinosaurs. Our results show that articular cartilage thickness and sub-articular shape are correlated. In mammals, joints become ever more congruent and thinner with increasing size, whereas archosaur joints remained both congruent and thick, especially in sauropods. We suggest that gigantism occurs less frequently in mammals, in part, because joints composed of thin articular cartilage can only become so congruent before stress cannot be effectively alleviated. In contrast, frequent gigantism in saurischian dinosaurs may be explained, in part, by joints with thick articular cartilage that can deform across large areas with increasing load.

  18. What lies beneath: sub-articular long bone shape scaling in eutherian mammals and saurischian dinosaurs suggests different locomotor adaptations for gigantism.

    Directory of Open Access Journals (Sweden)

    Matthew F Bonnan

    Full Text Available Eutherian mammals and saurischian dinosaurs both evolved lineages of huge terrestrial herbivores. Although significantly more saurischian dinosaurs were giants than eutherians, the long bones of both taxa scale similarly and suggest that locomotion was dynamically similar. However, articular cartilage is thin in eutherian mammals but thick in saurischian dinosaurs, differences that could have contributed to, or limited, how frequently gigantism evolved. Therefore, we tested the hypothesis that sub-articular bone, which supports the articular cartilage, changes shape in different ways between terrestrial mammals and dinosaurs with increasing size. Our sample consisted of giant mammal and reptile taxa (i.e., elephants, rhinos, sauropods plus erect and non-erect outgroups with thin and thick articular cartilage. Our results show that eutherian mammal sub-articular shape becomes narrow with well-defined surface features as size increases. In contrast, this region in saurischian dinosaurs expands and remains gently convex with increasing size. Similar trends were observed in non-erect outgroup taxa (monotremes, alligators, showing that the trends we report are posture-independent. These differences support our hypothesis that sub-articular shape scales differently between eutherian mammals and saurischian dinosaurs. Our results show that articular cartilage thickness and sub-articular shape are correlated. In mammals, joints become ever more congruent and thinner with increasing size, whereas archosaur joints remained both congruent and thick, especially in sauropods. We suggest that gigantism occurs less frequently in mammals, in part, because joints composed of thin articular cartilage can only become so congruent before stress cannot be effectively alleviated. In contrast, frequent gigantism in saurischian dinosaurs may be explained, in part, by joints with thick articular cartilage that can deform across large areas with increasing load.

  19. Granuloma periférico de células gigantes: a propósito de 5 casos y revisión de la literatura

    OpenAIRE

    Chaparro Avendaño, Angie Virginia; Berini Aytés, Leonardo; Gay Escoda, Cosme

    2005-01-01

    El granuloma periférico de células gigantes (GPCG) es una lesión reactiva benigna relativamente frecuente de la cavidad bucal. Se origina a partir del periostio o de la membrana periodontal tras una irritación o un traumatismo crónico que actúa localmente. Se manifiesta en forma de nódulo de color rojo-púrpura, situado en la encía o en el reborde alveolar edéntulo, preferentemente en la mandíbula. Aparece a cualquier edad, con una mayor incidencia entre la quinta y sex...

  20. A Mixed-Ligand Approach for a Gigantic and Hollow Heterometallic Cage {Ni64 RE96 } for Gas Separation and Magnetic Cooling Applications.

    Science.gov (United States)

    Chen, Wei-Peng; Liao, Pei-Qin; Yu, Youzhu; Zheng, Zhiping; Chen, Xiao-Ming; Zheng, Yan-Zhen

    2016-08-01

    Nanosized aggregations of metal ions shielded by organic ligands possessing both exquisite structural aesthetics and intriguing properties are fundamentally interesting. Three isostructural gigantic transition-metal-rare-earth heterometallic coordination cages are reported, abbreviated as {Ni64 RE96 } (RE=Gd, Dy, and Y) and obtained by a mixed-ligand approach, each possessing a cuboidal framework made of 160 metal ions and a nanosized spherical cavity in the center. Along with the structural novelty, these hollow cages show highly selective adsorptions for CO2 over CH4 or N2 at ambient temperatures. Moreover, the gadolinium analogue exhibits large magnetocaloric effect at ultralow temperatures.

  1. Consecuencias clínicas de la persistencia de actividad inflamatoria en la arteritis de células gigantes. Estudio de factores implicados

    OpenAIRE

    García Martínez, Ana

    2010-01-01

    La arteritis de células gigantes (ACG) afecta arterias de mediano y gran calibre. La inflamación de la carótida y sus ramas da lugar a los síntomas craneales típicos de la enfermedad. Las lesiones inflamatorias expresan gran cantidad de mediadores que provocan la muerte celular y la destrucción de fibras elásticas. El remodelado de la pared arterial puede dar lugar a alteraciones estructurales vasculares, como la aparición de estenosis arteriales que producen síntomas isquémicos o el desarrol...

  2. Escisión de un fibroma de células gigantes con láser de diodo: Informe de un caso

    Directory of Open Access Journals (Sweden)

    C.M. Ardila Medina

    Full Text Available Este artículo informa un caso de un fibroma gigantocelular localizado en tejido gingival y mucosa oral. Microscópicamente, la lesión se caracterizó por proliferación de fibras colágenas y fibroblastos gigantes, que se disponían en forma densa e irregular. Además, la superficie de la lesión estaba revestida por epitelio con cambios de hiperqueratosis. Se realizó escisión del fibroma con láser de diodo.

  3. Astrocitoma subependimario de células gigantes asociado a complejo de esclerosis tuberosa: recomendaciones para el diagnóstico oportuno y tratamiento.

    OpenAIRE

    Matilde Ruiz; Sandra Sánchez; Alejandro Rea; Roberto Sanromán; Joao García; Antonio Bravo; Infante Cantú; Hugo Ceja; Ariadna González; María del Mar Sáez

    2015-01-01

    RESUMEN El complejo de esclerosis tuberosa es una enfermedad genética poco frecuente, autosómica dominante con fenotipo y expresión clínica muy variables. Se caracteriza por alteraciones en la migración, diferenciación y proliferación celulares con formación de múltiples tumores benignos llamados hamartomas, las cuales afectan principalmente piel, encéfalo, riñón, ojo, corazón y pulmón. Los astrocitomas subependimarios de células gigantes son tumores benignos de crecimien...

  4. Evaluación de mantos de Macrosystis pyrifera "Sargazo Gigante" en la Península de Baja California (Verano de 1982)

    OpenAIRE

    Casas Valdez, María Margarita; Hernández Carmona, Gustavo; Torres Villegas, Julián René; Sánchez Rodríguez, Ignacio

    1985-01-01

    Se realizó una evaluación de los mantos de Macrocystis pyrifera ("Sargaso gigante") a lo largo de su distribución en la Península de Baja California. Las superficies cubiertas por los mantos se estimaron mediante fotografía aérea con película infrarroja y la biomasa se determinó mediante muestreos de campo en seis zonas diferentes. Se encontró que tanto las mayores superficies cubiertas por los mantos, como las mayores cosechas calculadas, corresponden a la zona sur (de la Isla Cedr...

  5. TROMBO GIGANTE DE AURÍCULA DERECHA COMO CAUSA DE ANGINA Y SÍNCOPE / Giant thrombus in right atrium as a cause of angina and syncope

    OpenAIRE

    José L. Aparicio Suárez; Mario E. Nápoles Lizano; Roberto Bermúdez Yera; Jean L. Chao García; Roger Mirabal Rodríguez; Yuri Medrano Plana

    2012-01-01

    ResumenLas tumoraciones intracardíacas son poco frecuentes, y pueden ser de tipo neoplásicas y no neoplásicas. De estas últimas, los trombos, constituyen las masas más frecuentes. Se presenta un paciente joven, operado en el Cardiocentro "Ernesto Che Guevara" de Villa Clara, Cuba, con antecedentes de trastornos hematológicos desde la infancia, que comienza con episodios de disnea progresiva, angina y síncope; con diagnóstico preoperatorio de tumoración gigante en aurícula derecha que resultó ...

  6. Caracterización imagenológica de la sinovitis vellonodular pigmentada y el tumor de células gigantes de la vaina sinovial

    Directory of Open Access Journals (Sweden)

    P. Schvartzman

    2015-01-01

    Conclusión: La sinovitis vellonodular pigmentada y el tumor de células gigantes de la vaina sinovial se consideran entidades similares desde el punto de vista anatomopatológico. La RM fue de gran utilidad para objetivar tanto las características radiológicas comunes como las diferenciales. Estas últimas, junto con la localización, nos permitieron clasificar 4 patrones de presentación. Su reconocimiento posibilita un adecuado seguimiento de la patología y un óptimo manejo terapéutico.

  7. Exéresis quirúrgica radical como único tratamiento del condiloma acuminado gigante: a propósito de un caso

    OpenAIRE

    Indalecio Parapar; Noel Taboada

    2007-01-01

    Los condilomas o verrugas genitales son producidos por el virus del papiloma humano del que existen más de 100 genotipos distintos. De ellos, cerca de 40 son transmitidos sexualmente. Se presenta el caso de una mujer con condiloma acuminado gigante de localización vulvo perineal y perianal, de cinco años de evolución que le dificultaba la micción, las relaciones sexuales, e incluso la marcha; además había fetidez, prurito y en ocasiones dolor. El examen histopatológico fue compatible con co...

  8. Mieloma múltiple y arteritis de células gigantes sin amiloidosis Simultaneous multiple myeloma and giant cell arteritis without systemic amyloidosis

    Directory of Open Access Journals (Sweden)

    Bárbara C. Finn

    2006-12-01

    Full Text Available La amiloidosis sistémica primaria y el mieloma múltiple con amiloidosis primaria se han presentado con características clínicas e histopatológicas que simulan una arteritis de células gigantes. Hasta el momento la asociación se basaba en el rol antigénico del depósito de amiloide sobre las arterias, desencadenando la respuesta inmune que finaliza con una arteritis. Presentamos el primer caso en la literatura de un paciente con mieloma múltiple y arteritis de células gigantes sin amiloidosis sistémica, sugiriendo una relación patogénica entre estas dos entidades. En el caso de nuestro paciente se descartó la presencia de amiloide en la pared arterial, por lo que proponemos que el estímulo para el desarrollo de la arteritis podría ser una excesiva producción de interleuquina 6 fabricada por las células mielomatosas.Primary systemic amyloidosis with clinical and histopathologic features of giant cell arteritis has already been described. The association of multiple myeloma (with primary amyloidosis and giant cell arteritis is also known. We present the first case in the literature of a patient with multiple myeloma and giant cell arteritis without systemic amyloidosis, suggesting a pathogenic relationship between the two diseases.

  9. Nevo melanocítico congénito gigante: presentación de tres casos Giants congenital melanocytic nevus: Report of three cases

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    V Estrella

    Full Text Available Los Nevos Melanocíticos Congénitos (NMC son lesiones pigmentarias, que pueden aparecer en el nacimiento, aunque hay casos comunicados hasta el primer año de vida (Nevo Melanocítico Congénito Tardío. Presentan ciertas características clínicas y evolutivas de gran importancia: el compromiso estético de las formas gigantes, la asociación con melanocitosis meníngea y su transformación maligna de la lesión cutánea o meníngea. Presentamos tres casos de nevos melanocíticos congénitos gigantes. Cabe destacar, que el objetivo de este artículo es realizar una revisión del tema, orientar al seguimiento y control de los mismos y destacar la dificultad para su tratamiento debido a su gran tamaño.The Congenital Melanocytic Nevus are lesions melanocytic pigmented. Already apparent at birth but there are cases reported to the first year of life (Late Congenital Melanocytic Nevus. Certain features and evolution clinics that are important: the great compromise of aesthetic forms giant, meningeal melanocitosis association and its malignant transformation. We present three cases of Giants Congenital Melanocytic Nevus. It should be noted, that the purpose of this article is a review of the issue and guide the monitoring and control of them and point out the difficult treatment.

  10. Paciente con complicación poco frecuente de arteritis de células gigantes Rare complication in a patient with giant cell arteritis

    Directory of Open Access Journals (Sweden)

    S. Olivera

    2010-12-01

    Full Text Available La arteritis de células gigantes (arteritis de la arteria temporal es una vasculitis crónica que afecta mayoritariamente a personas de edad avanzada. Aunque se trata de una enfermedad sistémica, se afectan sobre todo las arterias craneales. La complicación más frecuente de esta patología es la pérdida visual. Presentamos el caso clínico de una paciente que padeció varias complicaciones, entre ellas una necrosis lingual, a raíz de serle diagnosticada una arteritis de células gigantes tras iniciar el tratamiento de la misma.Giant cell arteritis (temporal arteritis is a chronic vasculitis that usually affects older people. Although this is a systemic disease, it most often affects the cranial arteries. The most frequent complication of this disorder is visual loss. We report the case of a patient who suffered several rare complications, including tongue necrosis, as a result of being diagnosed with giant cell arteritis following the start of treatment.

  11. Bocio multinodular gigante deformante. Presentación de un caso sin síntomas obstructivos

    Directory of Open Access Journals (Sweden)

    Paul Bogucki

    2014-04-01

    Full Text Available Se presenta el caso de un paciente masculino de 50 años, con una tumoración en la parte anterior de cuello de 25 años de evolución, sin síntomas de compresión. Al examen físico se aprecia una glándula tiroides de gran tamaño que deforma el cuello, de superficie lisa y nodular, de aproximadamente 16x12cm. Los estudios de imágenes y de laboratorio confirmaron el diagnóstico. Se practicó una tiroidectomía total, obteniéndose una glándula de 17x12cm. Se identificaron y preservaron ambos nervios laríngeos recurrentes y las glándulas paratiroides. No hubo complicaciones postoperatorias y el resultado estético fue satisfactorio. En conclusión el bocio es una patología común en las zonas con insuficiente aporte de Yodo, donde tiene una incidencia aproximada de 11%. Las estadísticas obtenidas en nuestro hospital se corresponden con lo publicado en la literatura internacional. La variedad gigante es infrecuente, constituyendo una causa de síntomas compresivos y disconformidad estética, por lo que la cirugía es la indicación terapéutica. Abstract Giant multinodular goiter. A case report with no obstructive symptoms In this report we show a 50 years male patient with a tumor in the anterior part of neck of 25 years of evolution, without symptoms of compression. Physical examination shows a large thyroid gland, which deforms the neck, smooth and nodular, painless to palpation, approximately 16x12cm. Imaging studies and laboratory-confirmed diagnosis of multinodular goiter. A total thyroidectomy was performed, with a gland 17x12cm. Were identified and preserved both recurrent laryngeal nerves and parathyroid glands. There were no postoperative complications and the aesthetic result was satisfactory. In conclusion the goiter is a condition common in areas with insufficient supply of iodine, which has an incidence of approximately 11%. The statistics obtained in our hospital are as published in the international literature to endemic

  12. Giant ovarian serous cystadenoma. A case report Cistadenoma seroso gigante de ovario. Presentación de un caso

    Directory of Open Access Journals (Sweden)

    Daniel Olivera Fajardo

    2011-04-01

    Full Text Available Ovarian tumors are not as common as uterus and breast tumors. They are regarded as the third group of women benign and malignant tumors. Ovarian serous cystadenomas arise from the superficial coelomic epithelium and are composed of cystic areas. There are macroscopically small tumors and massive tumors occupying the entire pelvis and even the abdominal cavity. The case of a 57 years old female patient with a history of apparent good health that attended consultation because of abdomen enlargement after a year of evolution is presented. The patient referred also nausea, loss of appetite and abdominal left flank pain. She was treated at the General Surgery Department of the General University Hospital "Dr. Gustavo Aldereguía Lima". Left oophorectomy was performed. Histopathological examination showed a giant serous ovarian cystadenoma. Pos-surgery evolution was satisfactory.Los tumores del ovario no son tan frecuentes como los del útero y los de la mama. Constituyen el tercer grupo de tumores benignos y malignos de la mujer. El cistadenoma seroso de ovario se deriva del epitelio superficial (celómico, formado por áreas quísticas. Hay tumores pequeños macroscópicamente y tumores masivos que ocupan toda la pelvis e incluso la cavidad abdominal. Se presenta el caso de una paciente de 57 años de edad, sexo femenino, con antecedentes aparentes de salud, que acudió a consulta por presentar aumento de volumen de su abdomen, de un año de evolución, acompañado de náuseas, pérdida de apetito y dolor abdominal en flanco izquierdo, la cual fue atendida en el Servicio de Cirugía General del Hospital General Universitario "Dr. Gustavo Aldereguía Lima". Se le realizó anexectomía izquierda. El estudio histopatológico arrojó un cistadenoma seroso gigante de ovario. La evolución posquirúrgica fue satisfactoria.

  13. Cystic dystrophy of the pancreas in patient with only one previous cyst Distrofia quística de páncreas en paciente con un solo quiste previo

    Directory of Open Access Journals (Sweden)

    E. Beleta

    2011-02-01

    Full Text Available Case report: we describe the case of a 46-year-old patient with cystic dystrophy of the pancreas admitted for alcoholic pancreatitis in a state of alcohol deprivation. The patient's background includes two cases of acute pancreatitis and a computed tomography taken 18 months prior to admittance reveals a 9 mm cyst in the first duodenal portion. Magnetic resonance imaging and endoscopic ultrasonography were consistent with cystic dystrophy of the pancreas without stenosis, for which reason treatment with octreotide was initiated. Discussion: it is believed to be a disease caused by obstruction of the ducts of the heterotopic pancreas and is associated with alcoholic pancreatitis. Its treatment is still under debate, but it requires pancreatectomy as a last option. Conclusion: cystic dystrophy of the pancreas is a rare disease and an effort should be made to bring together all of the described cases to increase our understanding of the disease.Introducción: la distrofia quística de páncreas en una enfermedad rara. Su diagnóstico es difícil y su tratamiento se halla en debate. Caso clínico: describimos el caso de un paciente de 46 años con distrofia quística de páncreas que ingresa por pancreatitis alcohólica en estado de deprivación alcohólica. Entre sus antecedentes destaca dos pancreatitis agudas y en un TC de 18 meses previo al ingreso un quiste de 9 mm en primera porción duodenal. Se realizó resonancia magnética y ecoendoscopia hallando imagen compatible con distrofia quística de páncreas sin estenosis, por lo que se inició tratamiento con octreótido. Discusión: se cree que se trata de una enfermedad causada por la obstrucción de los ductos del páncreas heterotópico y se asocia a pancreatitis alcohólica. Su tratamiento se encuentra todavía en debate pero requiere en última instancia de pancreatectomía. Conclusión: la distrofia quística de páncreas es una enfermedad rara y se debe intentar aunar todos los casos

  14. ASPECTOS MORFOANATÔMICOS DE FRUTOS DE TOMATEIRO CULTIVAR ÂNGELA GIGANTE, SUBMETIDOS A TRATAMENTOS COM REGULADORES VEGETAIS

    Directory of Open Access Journals (Sweden)

    MARIA BERNARDETE GONÇALVES MARTINS

    1997-01-01

    Full Text Available O presente trabalho teve como finalidade obter dados morfológicos de frutos de tomateiro, Lycopersicon esculentum Mill. `Ângela Gigante', submetidos à ação de reguladores vegetais, em dois ensaios que ocorreram em épocas distintas, em casa de vegetação. As mudas foram selecionadas e transplantadas para vasos com capacidade de 12 L de terra, contendo uma mistura de solo argiloso, areia, matéria orgânica e uma adubação mineral complementar de N, P, K. No segundo ensaio, após o transplante das mudas, além da adubação mineral complementar de N, P, K, efetuaram-se adubações adicionais (fertirrigação. Em ambos os ensaios, quando as plantas atingiram quatro folhas definitivas, realizaram-se as pulverizações com giberelina, GA3 50 mg/L; ácido naftalenacético, NAA 100 mg/L; cloreto (2-cloroetil trimetilamônio, CCC 1.500 mg/L e ácido succínico -2,2 dimetil-hidrazida, SADH 3.000 mg/L. Em relação aos estudos anatômicos, observou-se que os tratamentos com retardadores vegetais (CCC e SADH produziram frutos firmes, com formato tipo barril e ombros salientes; entretanto, em seção transversal, notou-se perda de viscosidade e atrofia de sementes, principalmente nos frutos de plantas tratadas com SADH. Os tratamentos com NAA e GA3 causaram eventual formação de frutos geminados. O tratamento com GA3 apresentou o parênquima do pericarpo com grãos de amido em processo de fragmentação, provavelmente em virtude de o GA3 acelerar a atividade da amilase, afetando o processo de maturação dos frutos e transformando o amido em açúcares. Notaram-se no mesocarpo células com grande quantidade de cristais de oxalato de cálcio sob a forma de areia cristalina. Do tratamento com CCC resultaram frutos suculentos com células da placenta degeneradas, deixando livre grande quantidade de mucilagem. O pericarpo apresentou grande quantidade de grãos de amido composto em toda a extensão, provavelmente por haver um atraso no processo de

  15. Gabapentina no tratamento da dor decorrente de cistos perineurais sacrais: relato de caso Gabapentina en el tratamiento del dolor decurrente de quistes perineurales sacrales: relato de caso Gabapentin to treat sacral perineural cyst-induced pain: case report

    Directory of Open Access Journals (Sweden)

    Elza Magalhães

    2004-02-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Os cistos perineurais podem gerar dor com características neuropáticas de difícil controle. Os anticonvulsivantes são medicações utilizados para tratamento de dores com essas características. O objetivo deste relato é mostrar um caso com total remissão da dor com uso de gabapentina após o insucesso no tratamento com todas as outras alternativas terapêuticas utilizadas. RELATO DE CASO: Paciente de 67 anos, diabética, com queixa de dor lombossacra há dois meses, com as seguintes características: diária, em pontada e queimação, de intensidade leve a moderada e com irradiação para região posterior da coxa. Piorava com o movimento e com a posição ortostática. Há seis meses havia tido um episódio semelhante de dor, que melhorou com o uso de corticoesteróides. A ressonância nuclear magnética da coluna lombossacra mostrava lesões císticas perineurais sacrais em S1, S2 e S3 com diâmetro de 2,5 a 4 cm, comprimindo o saco dural associado à erosão óssea. Foi introduzida a gabapentina em doses progressivas até 900 mg/dia, com alívio completo do quadro álgico. CONCLUSÕES: A dor neuropática provocada pelo cisto de Tarlov pode ser controlada de maneira adequada com gabapentina.JUSTIFICATIVA Y OBJETIVOS: Los quistes perineurales pueden generar dolor con características neuropáticas de difícil control. Los anticonvulsivantes son medicaciones utilizadas para tratamiento de dolores con esas características. El objetivo de este relato es mostrar un caso con total remisión del dolor con el uso de gabapentina después del mal suceso en el tratamiento con todas las otras alternativas terapéuticas utilizadas. RELATO DE CASO: Paciente de 67 anos, diabética, con queja de dolor lombosacra hace dos meses, con las siguientes características: diaria, en puntada y quemazón, de intensidad leve a moderada y con irradiación para región posterior del muslo. Peoraba con el movimiento y con la posici

  16. Hernia incisional gigante

    Directory of Open Access Journals (Sweden)

    Ada Arleny Pérez Mayo

    2014-08-01

    Full Text Available Se presentó el caso de paciente femenina de 53 años, intervenida por primera vez en el Hospital Nacional de San Pedro Necta del Departamento de Huehuetenango, en Guatemala, por una hernia incisional de 26 años de padecimiento. Se realizó cuidadosa preparación preoperatoria, que incluyó la antisepsia local de la piel y la aplicación de enemas evacuantes con Cloruro de Sodio al 0,9%. La técnica utilizada consistió en una incisión en Losange alrededor de la cicatriz anterior. Se procedió al cierre del anillo único de más de 10 cm de diámetro y la colocación de malla de polipropileno supra aponeurótica, con sutura no absorbible monofilamentosa. Fue posible el restablecimiento de la capacidad toraco-abdominal, al regresar las asas intestinales contenidas en el saco herniario a la cavidad. Se administró ceftriaxona, como antibiótico profiláctico. La paciente evolucionó satisfactoriamente y la estadía reportada fue de siete días. No ocurrieron complicaciones como seroma, hematoma o infección de la herida quirúrgica, que se atribuyó, en buena medida, a la colocación oportuna de drenajes durante 48 horas del postoperatorio. No hubo recidiva herniaria, con un seguimiento promedio de 19 meses; ni existieron manifestaciones de rechazo, atribuibles al material protésico

  17. No More Gigantism

    Science.gov (United States)

    Vohra, B. B.

    1975-01-01

    The food situation in India is critical. It requires the development of both land and water resources, both of which are largely untapped. Ground water is one undeveloped resource that can help alleviate the irrigation problems facing agriculture. More efficient utilization could free millions of hectares of land for cultivation. (MA)

  18. Bulla pulmonar gigante

    OpenAIRE

    Costi, David; Prat, Guillermo Daniel; Scarpelli, Franco; Ruiz, Camilo; Lorea, Bárbara

    2016-01-01

    Las bullas pulmonares es la alteración anatomía del parénquima pulmonar caracterizada por la sobre distención de los espacios aéreos distales al bronquio terminal con adelgazamiento, distención y destrucción de la pared alveolar. Estas pueden ser de origen congénito cuando se presentan en edad temprana o adquiridas que se dan en el adulto y generadas por factores de índole ocupacional o por el habito tabáquico. Las bullas al perder su anatomía alveolar normal se comportan cono espacios aéreos...

  19. Cuantificación de factores de riesgo para mastitis, quistes ováricos, hipocalcemia y cetosis usando regresión logística en ganado Holstein Quantification of risk factors for mastitis, ovarian cyst, milk fever and ketosis (in Holstein cattle using logistic regression in Holstein cattle

    Directory of Open Access Journals (Sweden)

    H. A. URIBE

    1998-01-01

    Full Text Available Métodos intensivos de producción de leche se han asociado con un incremento de problemas de salud del rebaño. Un aumento en producción de leche, ya sea por genética o manejo, no siempre parece ir acompañado por un aumento de rentabilidad de la empresa lechera. Se ha indicado que vacas de mayor producción tienen mayores demandas en mano de obra y una mayor frecuencia de enfermedades. El objetivo de este trabajo fue cuantificar algunos de los factores de riesgo en la incidencia de mastitis, quistes ováricos, hipocalcemia y cetosis. Casos clínicos, registrados como presentes o ausentes, fueron examinados usando regresión logística para cuantificar la asociación entre las enfermedades y las variables consideradas como factores de riesgo. Se estimaron las razones de riesgo y sus intervalos de confianza. Los datos fueron 8.391 observaciones en vacas Holstein canadienses. Los factores de riesgos considerados fueron: número de parto, estación de parto, año de parto, días en lactancia y producción de leche, grasa y proteína. Número de parto fue un factor de riesgo en todas las enfermedades estudiadas. Estación de parto y producción de leche fueron significativamente importantes para quistes ováricos e hipocalcemia. Producción de grasa y proteína no estuvieron asociadas con ninguna de las enfermedades. Días de lactancia estuvieron asociados con quistes ováricos, pero no está claro si días en lactancia es una causa o un efecto de quistes ováricosIntensive milk production methods have been related to an increase in health disorders. Milk yield improvement, either by genetics or management, is not always accompanied by a proportional increase in profits for dairy farmers. Cows with high milk yield have greater hand labour demands and a higher frequency of health disorders. The aim of this work was to asses some of the important risk factors in the incidence of mastitis, ovarian cyst, milk fever and ketosis. Clinical cases

  20. Aneurisma gigante da artéria cerebral média Giant aneurysm of the middle cerebral artery: a case report

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    J. Jorge Facure

    1974-03-01

    Full Text Available Relato de um caso de aneurisma gigante da artéria cerebral média esquerda operado com sucesso. O aneurisma que apresentava medidas de 35 x 27 x 23 mm determinou manifestações clínicas de hipertensão intracraniana. A sua exerese total resultou em pronto desaparecimento dos sintomas.A case of giant aneurysm of the left middle cerebral artery, in a 28-year-old right-handed woman, successfuly operated is reported. The aneurysm measur- ing 35 x 27 x 23 mm showed clinical manifestations as a space-occupying lesion. The patient recovered completely after the total excision of the aneurysm.

  1. Aneurisma intracraniano gigante em menino de três anos: relato de caso Giant intracranial aneurysm in three years old boy: case report

    OpenAIRE

    Osvaldo Inácio de Tella Jr; João Francisco Crosera; Marco Antonio Herculano; Manoel Antonio de Paiva Neto

    2006-01-01

    Aneurismas cerebrais são raros na faixa etária pediátrica. A apresentação destas lesões difere significativamente em relação á população adulta no que se refere a tamanho, localização e incidência. Relatamos caso de menimo de três anos de idade que apresentou quadro de hemorragia subaracnóidea sem história de infecções ou traumatismos prévios sendo, posteriormente, diagnosticado aneurisma gigante localizado na artéria cerebral média. Foi submetido a tratamento cirúrgico com boa evolução pós-o...

  2. Aspectos radiológicos e epidemiológicos do granuloma central de células gigantes Radiological and epidemiological aspects of central giant cell granuloma

    Directory of Open Access Journals (Sweden)

    José Wilson Noleto

    2007-06-01

    Full Text Available OBJETIVO: Este estudo teve como objetivo avaliar os principais aspectos radiográficos e epidemiológicos das lesões de células gigantes (granulomas centrais de células gigantes e tumores marrons do hiperparatireoidismo. MATERIAIS E MÉTODOS: A amostra consistiu de 26 lesões de células gigantes diagnosticadas em 22 pacientes divididos em dois grupos, um deles composto por 17 pacientes que não tinham hiperparatireoidismo (grupo A e o outro formado por cinco pacientes portadores de tal distúrbio (grupo B. RESULTADOS: O sexo feminino (72,7% foi o mais acometido. As lesões ocorreram mais freqüentemente na segunda década de vida, com média de idade de 27 anos. A mandíbula (61,5% foi o arco mais envolvido. Radiograficamente, 57,7% das lesões eram multiloculares e 42,3% eram uniloculares com limites definidos. Todas as 26 lesões provocaram expansão óssea, 15,4% produziram reabsorção radicular, 50% causaram deslocamento dentário e 11,5% produziram dor. Na mandíbula, 18,7% das lesões cruzavam a linha média. O grupo A apresentou 66,7% das lesões na mandíbula e o grupo B mostrou igualdade na distribuição das lesões entre os arcos. O grupo A apresentou 66,7% das lesões multiloculares e 33,3%, uniloculares. O grupo B apresentou 62,5% das lesões uniloculares e 37,5%, multiloculares. CONCLUSÃO: As lesões de células gigantes podem manifestar-se, radiograficamente, com um amplo espectro, desde pequenas lesões uniloculares de crescimento lento até extensas lesões multiloculares. Elas apresentam características de benignidade, embora algumas lesões possam demonstrar um comportamento localmente agressivo.OBJECTIVE: The present study was aimed at evaluating main radiological and epidemiological aspects of giant cell lesions (central giant cell granuloma and brown tumors of hyperparathyroidism. MATERIALS AND METHODS: The sample consisted of 26 giant cell lesions diagnosed in 22 patients divided into two groups, one of them

  3. Sotos syndrome (cerebral gigantism: analysis of 8 cases Síndrome de Sotos (gigantismo cerebral: análise de 8 casos

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    Débora Gusmão Melo

    2002-06-01

    Full Text Available Sotos syndrome or cerebral gigantism is characterized by macrocephaly, overgrowth, mental retardation and central nervous system abnormalities. Congenital heart defects may be present. We report 8 patients with this syndrome and relate their clinical features, neuroimaging and echocardiographic findings.A síndrome de Sotos ou gigantismo cerebral é caracterizada por macrocefalia, hipercrescimento, dismorfias faciais típicas, deficiência mental e alterações do sistema nervoso central. Malformações cardíacas podem estar presentes. Nós relatamos 8 pacientes com esta síndrome e descrevemos seus achados clínicos, de neuroimagem e ecocardiográficos.

  4. Generation of "gigantic" ultra-short microwave pulses based on passive mode-locking effect in electron oscillators with saturable absorber in the feedback loop

    Science.gov (United States)

    Ginzburg, N. S.; Denisov, G. G.; Vilkov, M. N.; Zotova, I. V.; Sergeev, A. S.

    2016-05-01

    A periodic train of powerful ultrashort microwave pulses can be generated in electron oscillators with a non-linear saturable absorber installed in the feedback loop. This method of pulse formation resembles the passive mode-locking widely used in laser physics. Nevertheless, there is a specific feature in the mechanism of pulse amplification when consecutive energy extraction from different fractions of a stationary electron beam takes place due to pulse slippage over the beam caused by the difference between the wave group velocity and the electron axial velocity. As a result, the peak power of generated "gigantic" pulses can exceed not only the level of steady-state generation but also, in the optimal case, the power of the driving electron beam.

  5. Onfalocele gigante. Presentación de un caso en sesión anatomopatológica y consideraciones generales

    OpenAIRE

    María del Carmen Ávila-Iglesias; Pedro Pasquel-García

    2015-01-01

    Paciente masculino producto de la primera gestación de madre de 20 años, originaria de medio rural en Guerrero. Control prenatal irregular en un Centro de Salud. Se efectuó un ultrasonido con aparente alteración del cordón umbilical no especificada, sin recibir manejo ni referencia a tercer nivel. Obtenido por vía abdominal por sufrimiento fetal agudo en clínica rural, presentó llanto inmediato, pesó 2 800 g y se desconocen talla y Apgar al nacer. Un onfalocele gigante fue evidente desde el n...

  6. Granuloma periférico de células gigantes. A propósito de 5 casos y revisión de la literatura

    OpenAIRE

    Chaparro Avendaño, Angie V.; Berini Aytés, Leonardo; Gay Escoda, Cosme

    2005-01-01

    El granuloma periférico de células gigantes (GPCG) es una lesión reactiva benigna relativamente frecuente de la cavidad bucal. Se origina a partir del periostio o de la membrana periodontal tras una irritación o un traumatismo crónico que actúa localmente. Se manifiesta en forma de nódulo de color rojo-púrpura, situado en la encía o en el reborde alveolar edéntulo, preferentemente en la mandíbula. Aparece a cualquier edad, con una mayor incidencia entre la quinta y sexta décadas de la vida, c...

  7. Cisto intraespinal em comunicação com o disco intervertebral na coluna lombar: relato de um caso e revisão da literatura Quiste intraespinhal en comunicación con el disco intervertebral em la columna lumbar: reporte de caso y revisión de la literatura Intraspinal cyst communicating with the intervertebral disk in the lumbar spine: case report and literature review

    Directory of Open Access Journals (Sweden)

    Mauricio Marteleto Filho

    2012-12-01

    Full Text Available A hérnia discal lombar é causa importante bem como a mais freqüente de lombalgia e ciática. Muitos dos casos podem prontamente ser diagnosticados através do simples exame semiológico. A ressonância nuclear magnética (RNM estabelece um diagnóstico definitivo mesmo em bases ambulatoriais. Diversos tipos de cistos intraespinais com diferentes patogenias foram descritos no passado como cistos perineurais, cistos sinoviais, cistos aracnóides e cistos ganglionares, que são doenças difíceis de diferenciar da hérnia de disco lombar. Os autores observaram recentemente um caso de cisto intraespinal comunicante com o disco intervertebral correspondente, apresentando sinais e sintomas e mesmo alguns achados radiológicos indistinguíveis daqueles da herniação discal lombar. O diagnóstico foi estabelecido pela RNM e confirmado no momento da cirurgia. Este artigo descreve as características dessa entidade clínica, incluindo quadro clínico, aparência radiográfica e achados histológicos, a fim de discutir possíveis patogenias e tratamento.Una hernia de disco lumbar es una causa importante, así como la más frecuente causa del dolor lumbar y ciática. Muchos casos pueden ser fácilmente diagnosticados por el examen semiológico simple. La resonancia magnética (RM proporciona un diagnóstico definitivo, incluso en atención ambulatoria. Varios tipos de quistes intraespinales con diferentes patogénesis se han descrito en el pasado como quistes perineurales, quistes sinoviales, los quistes aracnoideos y quistes ganglionares, enfermedades que son difíciles de diferenciar de la hernia de disco lumbar. Los autores observaron recientemente un caso de quiste intraespinal, que en comunicación con el disco intervertebral correspondiente, presentando signos y síntomas e incluso algunos hallazgos radiológicos que no se distinguen de los de la hernia discal lumbar. El diagnóstico fue determinado por RM y confirmado en la cirugía. En este art

  8. Onfalocele gigante. Presentación de un caso en sesión anatomopatológica y consideraciones generales

    Directory of Open Access Journals (Sweden)

    María del Carmen Ávila-Iglesias

    2015-05-01

    Full Text Available Paciente masculino producto de la primera gestación de madre de 20 años, originaria de medio rural en Guerrero. Control prenatal irregular en un Centro de Salud. Se efectuó un ultrasonido con aparente alteración del cordón umbilical no especificada, sin recibir manejo ni referencia a tercer nivel. Obtenido por vía abdominal por sufrimiento fetal agudo en clínica rural, presentó llanto inmediato, pesó 2 800 g y se desconocen talla y Apgar al nacer. Un onfalocele gigante fue evidente desde el nacimiento y fue trasladado por sus propios familiares durante seis horas en malas condiciones, sin aporte enteral ni parenteral y con defecto abdominal sin cubrir. A su ingreso al Instituto Nacional de Pediatría se encontraba en estado de choque, por lo que se le intubó y se le pasaron 2 bolos de cristaloide a 10 mL/kg. Se describió un onfalocele gigante de 10 cm cubierto por gelatina de Wharton, con hígado, intestino delgado y estómago. Se practicó aseo con yodopovidona y se cubrió el defecto con gasa, sin posibilidad de colocar silo debido al gran tamaño del defecto y a la cavidad abdominal estrecha.

  9. Testicular epidermoid cyst; Quiste epidermoide testicular

    Energy Technology Data Exchange (ETDEWEB)

    Rabaza, M. J.; Medina, A.; Lopez, G.; Pardo, P. [Hospital Universitario Virgen de las Nieves. Granada (Spain)

    2001-07-01

    The testicular epidermoid cyst is an uncommon benign tumor that represents 1% to 2% of resected testicular masses. The observation of the characteristic ultrasonographic features of these lesions facilitates their diagnosis and may make it possible to perform enucleation, obviating the need for orchidectomy. We present two cases in which the testicular epidermoid cysts were diagnosed preoperatively and their presence confirmed after conservative surgery. We review the literature concerning imaging studies and the management of these lesions. (Author) 9 refs.

  10. Growth hormone (GH) secretory dynamics in a case of acromegalic gigantism associated with hyperprolactinemia: nonpulsatile secretion of GH may induce elevated insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 levels.

    Science.gov (United States)

    Yoshida, T; Shimatsu, A; Sakane, N; Hizuka, N; Horikawa, R; Tanaka, T

    1996-01-01

    We describe a case of pituitary gigantism with low levels of growth hormone (GH), elevated insulin-like growth factor-I (IGF-I), and IGF-binding protein-3 (IGF-BP-3). The patient had characteristic clinical features of gigantism and acromegaly. The basal serum GH levels ranged from 1.2-1.9 micrograms/L, which were considered to be within normal limits. Serum GH response to either insulin-induced hypoglycemia or GH-releasing hormone was blunted. Frequent blood samplings during daytime and at night showed nonpulsatile GH secretion. Serum prolactin, IGF-I and IGF-binding protein-3 levels were elevated. After unsuccessful surgery, bromocryptine treatment normalized serum prolactin without affecting serum GH and IGF-I levels. Combined administration of octreotide and bromocryptine reduced serum GH and IGF-I levels. GH bioactivity as measured by Nb2 cell proliferation assay was within reference range. In the present case, nonpulsatile GH secretion and enhanced tissue sensitivity to GH may induce hypersecretion of IGF-I and IGF-BP-3 and cause clinical acromegalic gigantism.

  11. 巨趾畸形12例临床分析%Digital gigantism of the foot: a clinical study of 12 cases

    Institute of Scientific and Technical Information of China (English)

    王海华; 田光磊; 诸寅; 张友乐; 赵俊会; 田文

    2008-01-01

    Objective To summarize the clinical characteristic and outcome of digital gigantism of the foot.Methods Retrospectively analyze the clinical documents of cases of digital gigantism of the foot.Twelve 12 cases witIl 13 feet in this study included 8 male and 4 female with an average 4.6 years old.All the deformities were found at birth.Multiple toes involved were more than single toe.and tibial toe involved mole than fibular.Forefoot was enlarged.All the phalanges involved and partial metatarsal bones were enlarged.Marked inclease in subcutaneous fat was found in all cases in the operation which infiltrated interossei and articular capsules.The appearance of the nerves and its branches in the foot were normal and fat infiltrating was not discovered.The operation types included debulking,epiphyseal arrest,amputation,nerve stripping and anastomosis.Results Seven cases were followed up with mean periods 25.6 months.Functional evaluation according to a criterion formulated by anthor revealed a result of 2 excellent.2 good and 3 faiL Conclusions Digital gigantism of the foot iS an uncommon congenital deformity of the foot characterized by overgrowth of both the soft-tissue and the osseous elements of the enlarged toe and forefoot.Surgical treatment is the unique method,and the goal is to reduce the size of the foot to allow fitting regular shoes and walking readily.There are several types of operations which to be chosen.The indication.the timing of operative intervention and the selection of operation type should be paid more attention.%目的 总结巨趾畸形的临床特点和手术疗效.方法 回顾性分析12例巨趾畸形患者的临床资料.共12例(13足)患者,其中男性8例,女性4例,平均年龄4.6岁.均在出生时被发现畸形.多趾巨大畸形患者多于单趾畸形的患者,胫侧足趾好发.对应的前足均粗大.巨趾的趾骨均粗长,部分对应的跖骨粗长.术中见所有患者均有皮下脂肪过度增生,侵犯骨间肌和关

  12. Loss of heterozygosity on chromosome 11q13 in two families with acromegaly/gigantism is independent of mutations of the multiple endocrine neoplasia type I gene.

    Science.gov (United States)

    Gadelha, M R; Prezant, T R; Une, K N; Glick, R P; Moskal, S F; Vaisman, M; Melmed, S; Kineman, R D; Frohman, L A

    1999-01-01

    Familial acromegaly/gigantism occurring in the absence of multiple endocrine neoplasia type I (MEN-1) or the Carney complex has been reported in 18 families since the biochemical diagnosis of GH excess became available, and the genetic defect is unknown. In the present study we examined 2 unrelated families with isolated acromegaly/gigantism. In family A, 3 of 4 siblings were affected, with ages at diagnosis of 19, 21, and 23 yr. In family B, 5 of 13 siblings exhibited the phenotype and were diagnosed at 13, 15, 17, 17, and 24 yr of age. All 8 affected patients had elevated basal GH levels associated with high insulin-like growth factor I levels and/or nonsuppressible serum GH levels during an oral glucose tolerance test. GHRH levels were normal in affected members of family A. An invasive macroadenoma was found in 6 subjects, and a microadenoma was found in 1 subject from family B. The sequence of the GHRH receptor complementary DNA in 1 tumor from family A was normal. There was no history of consanguinity in either family, and the past medical history and laboratory results excluded MEN-1 and the Carney complex in all affected and unaffected screened subjects. Five of 8 subjects have undergone pituitary surgery to date, and paraffin-embedded pituitary blocks were available for analysis. Loss of heterozygosity on chromosome 11q13 was studied by comparing microsatellite polymorphisms of leukocyte and tumor DNA using PYGM (centromeric) and D11S527 (telomeric), markers closely linked to the MEN-1 tumor suppressor gene. All tumors exhibited a loss of heterozygosity at both markers. Sequencing of the MEN-1 gene revealed no germline mutations in either family, nor was a somatic mutation found in tumor DNA from one subject in family A. The integrity of the MEN-1 gene in this subject was further supported by demonstration of the presence of MEN-1 messenger ribonucleic acid, as assessed by RT-PCR. These data indicate that loss of heterozygosity in these affected family

  13. Granuloma reparativo de células gigantes agresivo en región mandibular Aggressive giant cells reparative granulomas in mandibular region

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    Ernesto Sánchez Cabrales

    2010-06-01

    Full Text Available El granuloma reparativo de células gigantes (GRCG es un proceso reactivo agresivo, que aparece con mayor frecuencia en los sectores anteriores de la mandíbula y el maxilar, en niños y adolecentes jóvenes. Constituye el 1 % de las lesiones óseas tumorales. Existe una considerable controversia acerca de si son lesiones benignas o reactivas; también desde el punto de vista de su origen, de sus características clínicas e histológicas, así como su terapéutica. En octubre de 2007 acudió un caso a consulta externa de Cirugía Maxilofacial del Hospital Pediátrico Universitario "Juan M. Márquez", con una lesión diagnosticada como GRCG agresivo, la cual provocó gran deformidad facial y osteólisis del cuerpo mandibular. Se realizaron exámenes físicos, complementarios e iconopatográfico. Se ejecutó tratamiento quirúrgico y análisis de la pieza. La paciente no tuvo alteraciones estéticas ni funcionales. Hubo ausencia de recidiva, luego de 30 meses de seguimiento. Se revisó la literatura más reciente en los sitios Med Line, Lilac, Google, con las palabras clave granuloma reparativo de células gigantes, en inglés y español, para comparar nuestros procederes y resultados con otros reportes.The giant cells reparative granulomas (GCRG is a reactive and aggressive process appearing more frequently in anterior sector of mandible and maxilla in children and young adolescents accounting for the 1 % of tumor bone lesions. There is a considerable controversy if they are benign or reactive lesions from the point of view of its origin, from its clinical and histological features as well as therapeutical. This is the case of a patient seen in external consultation of Maxillofacial Surgery of the "Juán Manuel Márquez" Children and University Hospital at October, 2007 in whom an extent lesion diagnosed as an aggressive GCRG provoked a facial deformity and osteolysis of mandibular body. Complementary, physical and iconopathographic examinations

  14. Utilización de Colloss® para el tratamiento de quistes mandibulares: Descripción de una serie clínica The use of lyophilized bovine collagen (Colloss® for treating mandibular cysts: Description of a clinical series

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    J. Arias Gallo

    2007-08-01

    Full Text Available La enucleación de quistes óseos conlleva la aparición de defectos óseos. Se acepta que los cuando son menores de 3 cm. de diámetro y están alejados del reborde alveolar se rellenan de hueso neoformado en unos meses. Por el contrario, defectos óseos mayores no regeneran completamente. "Colloss®" parece ser un interesante material osteoinductivo. Se trata de un complejo liofilizado de las proteínas extracelulares extraídas del hueso bovino diafisario. Contiene fundamentalmente colágeno tipo I y cantidades variables de BMPs. En el período comprendido entre Febrero de 2002 y Enero de 2004 se utilizó colágeno liofilizado bovino para la reconstrucción ósea de 7 pacientes con quistes mandibulares tratados en el Hospital Universitario La Paz (Madrid. Este material se combinó con injertos óseos autólogos o con mallas de titanio en varios de los casos. Se observó en la totalidad de los casos una adecuada regeneración ósea. En dos de los casos, en los que se mezcló Colloss® con hueso autólogo se produjo el rechazo de este último. Tras sus retirada el proceso curativo discurrió sin incidencias. También se constató una tendencia a la exposición intraoral de las mallas de titanio sin que ello se viese reflejado en el proceso de curación. Podemos señalar como ventajas de la utilización del colágeno liofilizado bovino (Colloss® para el tratamiento de quistes odontogénicos: su capacidad osteoinductiva demostrada; la ausencia de efectos adversos de importancia y su utilidad en la determinación precoz de recidivas. Como posibles desventajas destacaríamos: su difícil manejo; la conveniencia de encontrar un carrier adecuado que permitiese una manipulación más sencilla, la necesidad de ajustar la dosis necesaria de forma precisa y, por último, las complicaciones potenciales relacionadas con cualquier tipo de xenoinjerto de origen bovino.The treatment of mandible bone cysts commonly leads to the development of bone defects

  15. Investigación experimental de la equinococosis canina a partir de quiste hidatídico de origen porcino en México Experimental investigation of canine echinococcosis from swine hydatic cyst in Mexico

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    Ismael Zuñiga-A

    1999-06-01

    Full Text Available OBJETIVO: Para evaluar la infección y obtener el estado adulto del cestodos, se buscó reproducir la equinococosis en perros a partir de quiste hidatídico de origen porcino. MÉTODOS: Se formaron 2 grupos, uno de 5 y otro de 3 perros, a cada animal del grupo experimental se le dió 2 g de membrana germinativa de quíste hidatídico fértil por vía oral, el segundo grupo fue testigo. Ambos grupos fueron evaluados clínica, serológica y parasitológicamente, en el grupo experimental se sacrificó un animal el día 35 de la infección y los siguientes cada 5 dias hasta el 55, en el segundo grupo todos se sacrificaron el día 55. Se observaron huevos del cestodos en heces a partir del dia 51 postinfección. La evaluación morfol��gica se realizó mediante observación microscópica del raspado de mucosa intestinal. RESULTADOS: De 50 cestodos analizados, 10 de cada uno de los perros infectados, 49 (98% presentaron 3 proglótidos y 1 (2% tenía 4; 18 (36% de los cestodos presentaban un proglótido grávido. La longitud de los estróbilos varió de 1,6 a 2,6 mm. El número promedio de los ganchos largos y cortos fue de 31 y 34 respectivamente. La longitud de los ganchos largos varió entre 0,081 y 0,09 mm, los ganchos cortos fluctuaron entre 0,034 y 0,041 mm. En los perros evaluados clínicamente, el número de leucocitos y la cantidad de proteínas plasmáticas fue significativamente mayor en el grupo testigo (P OBJETIVO: Avaliar a infeção e obter o estado adulto do cestóides, provocando-se a reprodução da equinococose em cães a partir do cisto hidático de origem suína. MÉTODOS: Formaram-se dois grupos, um de 5 e outro de 3 cães. Cada animal do grupo experimental recebeu, por via oral, 2 g de membrana germinativa de cisto hidático fértil. O segundo grupo serviu como testemunha. Ambos os grupos foram avaliados de maneira clínica, sorológica e parasitológica. No grupo experimental foi sacrificado um animal no 35º dia da infe

  16. Aneurisma gigante da artéria cerebral posterior: (segmento P3 Relato de caso Giant aneurysm of the posterior cerebral artery (P3 segment: case report

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    Ronaldo Pereira

    1995-09-01

    Full Text Available Apresentamos caso de aneurisma gigante do segmento distal (P3 da artéria cerebral posterior. O aneurisma foi tratado microcirurgicamente pela via combinada proposta por Sano com clipagem do ramo terminal da artéria cerebral posterior próximo ao aneurisma. A paciente teve evolução pós operatória favorável, com lesão parcial e transitória do III nervo craniano. Revisão da literatura e discussão a respeito da anatomia e da abordagem cirúrgica são feitas. A raridade desta patologia justifica o relato deste caso.A rare case of giant aneurysm of the P3 segment of the posterior cerebral artery is presented. The aneurysm was acessed through a combined approach proposed by Sano and the aneurysm was treated by proximal clipping. The patient had a good postoperative recovery without any neurological deficit. The anatomy and the operative approaches are discussed and the neurosurgical literature reviewed.

  17. Florística em um hectare de cerrado stricto sensu na ARIE - cerrado Pé-de-Gigante, Santa Rita do Passa Quatro, SP

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    Weiser Veridiana de Lara

    2001-01-01

    Full Text Available Foi realizado um levantamento florístico em um ha de cerrado stricto sensu, na parte norte da ARIE - Cerrado Pé-de-Gigante, Santa Rita do Passa Quatro, São Paulo. Foram coletados 428 espécimes em fase reprodutiva, em vinte e cinco excursões de coleta, durante o período de novembro de 1996 a abril de 1998. A listagem florística obtida apresenta 141 espécies, distribuídas em 109 gêneros e 49 famílias. As famílias mais representativas foram: Leguminosae, Asteraceae, Malpighiaceae e Myrtaceae. A floração e frutificação das espécies foram maiores no período chuvoso. Espécies zoocóricas (61 predominaram, seguidas pelas anemocóricas (46 e autocóricas (34. Analisou-se a flora como um todo e seus componentes herbáceo-subarbustivo e arbustivo-arbóreo, separadamente.

  18. Mucoceles gigantes: visão neurocirúrgica. Relato de dois casos Giant mucoceles: neurosurgical view. Report of two cases

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    Mirto N. Prandini

    2005-06-01

    Full Text Available São apresentados dois casos de mucocele gigante do seio frontal submetidos a tratamento cirúrgico. A manifestação clínica foi cefaléia de evolução prolongada, associada com protrusão unilateral do globo ocular de curta duração. Em ambos os casos foi realizada craniotomia frontal com remoção completa da lesão, reparação do soalho frontal com retalho pediculado de gálea e cranialização do seio frontal. No segundo caso, uma abordagem endoscópica intranasal foi combinada à abordagem externa no mesmo ato cirúrgico. Alguns aspectos abordando a etiologia, associação com outras afecções e tratamento cirúrgico são discutidos.Two patients harboring giant frontal mucoceles are reported. In both cases complaints of chronic headaches and progressive unilateral proptosis were preponderant. Surgical treatment included a frontal craniotomy with excision of the lesion, skull base reinforcement with pedicled galea and wide opening of the frontal sinuses. In the second case an intranasal endoscopic approach was combined with craniotomy at the same surgical operative time. Some aspects regarding etiology, association with other diseases and some surgical aspects are discussed.

  19. Hemangioma hepático gigante asociado a síndrome de Kasabach-Merrit Giant hepatic hemangioma associated with Hodgkin's lymphoma

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    M. Valdés Mas

    2008-08-01

    Full Text Available El hemangioma hepático es el tumor benigno más frecuente del hígado. La gran mayoría de ellos son de pequeño tamaño, asintomáticos y con un pronóstico excelente. En raras ocasiones son de mayor tamaño y pueden estar asociados a una coagulopatía de consumo denominada síndrome de Kasabach-Merrit. Presentamos el caso de un paciente varón joven con un hemangioma hepático gigante y hemangiomatosis múltiple asociado al síndrome de Kasabach-Merrit.Hepatic hemangioma is the most frequent liver's tumor. The majority are small, asymptomatic and have an excellent prognosis. Those larger than 5 cm can be associated to a consumptive coagulopathy called Kasabach-Merrit syndrome. We present a patient with a giant hepatic hemangioma with multiple hemangimatosis associated to Kasabach-Merrit syndrome.

  20. Impacto da participação especial em campos gigantes offshore de petróleo Impact of special participation tax in offshore petroleum giant fields

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    Rodrigo Mendes Gandra

    2006-08-01

    Full Text Available Utilizando um cenário como estudo de caso, objetiva-se explorar o impacto econômico da Lei que rege a cobrança da Participação Especial (PE pela Agência Nacional do Petróleo (ANP sobre a decisão de investimento em projetos situados exclusivamente em campos gigantes de petróleo no Brasil. Embora este seja um exercício indutivo sem maiores pretensões, ele pode ser tomado como representativo para retratar a realidade das grandes empresas que têm em seu portfolio oportunidades de desenvolvimento de concessões com grande potencial petrolífero. Subsidiariamente, propõe-se uma alternativa ao modelo de tributação vigente.The main objective of this technical study is to show the economic impact of Special Participation Tax on decisions at projects of investments at Brazilian offshore fields with high production of petroleum. An alternative estimation approach is proposed in this paper for Special Participation Tax to facilitate the economic viability of offshore projects. This technical study is only a exercise of a real situation which big companies face when it have the opportunity to develop concessions with high potential of petroleum. Above all, we propose an alternative way to calculate the assessment.

  1. Tumor de células gigantes costal ocupando todo o hemitórax Giant cell tumor of the rib occupying the entire hemithorax

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    Samuel Zuínglio de Biasi Cordeiro

    2008-03-01

    Full Text Available Os autores relatam o caso de uma paciente de 28 anos de idade portadora de tumor de células gigantes originário da costela. O tumor de grandes dimensões (25 × 17 cm ocupava todo o hemitórax e causava atelectasia do pulmão esquerdo. Tratava-se de uma neoplasia mesenquimal benigna, a qual raramente acomete as costelas. Foi realizada toracotomia com ressecção em bloco da parede torácica e do tumor. O objetivo deste artigo é enfatizar que, apesar da grande dimensão do tumor, ele pôde ser completamente ressecado, e o pulmão foi reabilitado.The authors report the case of a 28-year-old female patient with a giant cell tumor originating from the rib. The tumor, measuring 25 × 17 cm, occupied the entire hemithorax and caused atelectasis of the left lung. This tumor was a benign mesenchymal neoplasm, which rarely affects the ribs. A thoracotomy involving en bloc resection of the chest wall and tumor was performed. Despite the large dimensions of the tumor, complete resection was possible, and lung function was restored.

  2. A probable case of gigantism/acromegaly in skeletal remains from the Jewish necropolis of "Ronda Sur" (Lucena, Córdoba, Spain; VIII-XII centuries CE).

    Science.gov (United States)

    Viciano, Joan; De Luca, Stefano; López-Lázaro, Sandra; Botella, Daniel; Diéguez-Ramírez, Juan Pablo

    2015-01-01

    Pituitary gigantism is a rare endocrine disorder caused by hypersecretion of growth hormone during growing period. Individuals with this disorder have an enormous growth in height and associated degenerative changes. The continued hypersecretion of growth hormone during adulthood leads to acromegaly, a condition related to the disproportionate bone growth of the skull, hands and feet. The skeletal remains studied belong to a young adult male from the Jewish necropolis of "Ronda Sur" in Lucena (Córdoba, Spain, VIII-XII centuries CE). The individual shows a very large and thick neurocranium, pronounced supraorbital ridges, an extremely prominent occipital protuberance, and an extremely large and massive mandible. Additional pathologies include enlargement of the vertebral bodies with degenerative changes, thickened ribs, and a slight increased length of the diaphysis with an increased cortical bone thickness of lower limbs. Comparative metric analysis of the mandible with other individuals from the same population and a contemporary Mediterranean population shows a trend toward acromegalic morphology. This case is an important contribution in paleopathological literature because it is a rare condition that has not been widely documented in ancient skeletal remains.

  3. Tumor de células gigantes de bainha de tendão no LCA Tendon sheath giant cells tumor in ACL

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    André Pedrinelli

    2007-01-01

    Full Text Available Trata-se de um relato de caso de tumor de células gigantes de bainha do ligamento cruzado anterior, uma localização extremamente rara para esse tipo de lesão. O paciente do sexo feminino apresentava dor no joelho, sem relato de trauma anterior. Foi submetido ao exame clínico, ao estudo radiográfico e de ressonância magnética da região. Feita a hipótese diagnóstica de TGC de Bainha, o paciente foi então tratado com ressecção artroscópica do tumor. O diagnóstico foi confirmado com exame anátomo-patológico. O paciente evoluiu bem, com melhora dos sintomas referidos no pré-operatório.The author presents a case report of Tumor Giant Cells (TGC localized on the anterior cruciate ligament sheath, an extremely rare site for this kind of lesion. A 37 y-o female patient presented with knee pain, with no history of previous trauma. She underwent clinical examination, X-ray study and magnetic resonance of the region. The diagnostic hypothesis of Sheath TGC was provided, and the patient was treated with tumor arthroscopy resection. Diagnosis was confirmed by anatomicopathological examination. By the end point assessment, none of the pre-operative symptoms were reported.

  4. Aneurisma intracraniano gigante em menino de três anos: relato de caso Giant intracranial aneurysm in three years old boy: case report

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    Osvaldo Inácio de Tella Jr

    2006-06-01

    Full Text Available Aneurismas cerebrais são raros na faixa etária pediátrica. A apresentação destas lesões difere significativamente em relação á população adulta no que se refere a tamanho, localização e incidência. Relatamos caso de menimo de três anos de idade que apresentou quadro de hemorragia subaracnóidea sem história de infecções ou traumatismos prévios sendo, posteriormente, diagnosticado aneurisma gigante localizado na artéria cerebral média. Foi submetido a tratamento cirúrgico com boa evolução pós-operatória.Cerebral aneurysms are rare in the pediatric age group and differ from adults with aneurysms in size, localization and incidence. We report a 3-year-old boy with giant middle cerebral artery aneurysms who presented with subarachnoid hemorrhage. The patient was submitted to surgical treatment and the postoperative period was uneventful.

  5. Gigantism treated by pure endoscopic endonasal approach in a case of McCune-Albright syndrome with sphenoid fibrous dysplasia: a case report.

    Science.gov (United States)

    Sharifi, Guive; Jalessi, Maryam; Sarvghadi, Farzaneh; Farhadi, Mohammad

    2013-12-01

    McCune-Albright syndrome (MAS) is an uncommon polyostotic manifestation of fibrous dysplasia in association with at least one endocrinopathy that is mostly associated with precocious puberty and hyperpigmented skin macules named café-au-lait spots. We present an atypical manifestation of McCune-Albright syndrome in a 19-year-old man with the uncommon association of polyostotic fibrous dysplasia and gigantism in the absence of café-au-lait spots and precocious puberty. He presented with a height increase to 202 cm in the previous 3 years, which had become more progressive in the few months prior. Physical examination revealed only a mild facial asymmetry; however, a computed tomography (CT) scan discovered vast areas of voluminous bones with ground-glass density and thickening involving the craniofacial bones and skull base. Magnetic resonance imaging (MRI) found a right stalk shift of the pituitary with a 20 mm pituitary adenoma. We describe the diagnostic and endoscopic endonasal transsphenoidal approach for excision of the tumor.

  6. Condiloma gigante del pene (Tumor de Buschke-Lowenstein: Presentación de un caso Peneal Buschke-Lowenstein tumor: Case report

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    A.A. Núñez Serrano

    2009-03-01

    Full Text Available El condiloma gigante del pene o tumor de Buschke- Lowenstein, es un tumor epitelial benigno de origen viral y sexualmente transmisible, que en raros casos puede malignizar. Presentamos un paciente en el que el condiloma de localización peneana, creció rápidamente y destruyó estructuras. Su histología se caracteriza por papilomatosis y acantosis endo y exofítica. Existen diferentes tratamientos del tumor, pero el más efectivo es la extirpación quirúrgica radical para evitar recidivas y malignización.Buschke-Lowenstein tumour is an epithelial benign tumour sexually transmitted with a viral origin. We present a case of peneal localization with exofitic growth, compression and displacement of the deeper tissues, ulceration and urethral fistulae. Histology is characterized by papillomatosis and endo or exophytic acantosis. Local malignancy is still discussed. There are many possible treatments, but radical excision is the best to avoid malignant transformation and recurrences.

  7. Buschke -Loewenstein tumor: identification of HPV type 6 and 11 Condiloma acuminado gigante de Buschke-Lowenstein: identificação dos HPV 6 e 11

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    Juliana Casagrande Tavoloni Braga

    2012-02-01

    Full Text Available The authors report a case of exuberant giant condyloma acuminatum of Buschke-Loewenstein in a male patient, slow-growing, progressive and with locally destructive behavior in the inguinal, body of the penis, scrotum, perineal and perianal regions. After surgery he showed no signs of recurrence in 20 months of follow-up. The identification of HPV types 6 and 11 was performed using in situ hybridization.Os autores relatam um caso exuberante de condiloma acuminado gigante de Buschke-Lowenstein, em paciente do sexo masculino, de crescimento lento e progressivo e de comportamento destrutivo das regiões inguinal, corpo do pênis, escroto, perineal e perianal. Após tratamento cirúrgico, não apresentou sinais de recidiva em 20 meses de seguimento. A identificação dos HPVs, tipos 6 e 11, foi realizada através da técnica de hibridização in situ.

  8. Exéresis quirúrgica radical como único tratamiento del condiloma acuminado gigante: a propósito de un caso

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    Indalecio Parapar

    2007-06-01

    Full Text Available Los condilomas o verrugas genitales son producidos por el virus del papiloma humano del que existen más de 100 genotipos distintos. De ellos, cerca de 40 son transmitidos sexualmente. Se presenta el caso de una mujer con condiloma acuminado gigante de localización vulvo perineal y perianal, de cinco años de evolución que le dificultaba la micción, las relaciones sexuales, e incluso la marcha; además había fetidez, prurito y en ocasiones dolor. El examen histopatológico fue compatible con condiloma acuminado. Se realizó extirpación quirúrgica radical del tumor con excelentes resultados funcionales y cosméticos, sin complicaciones postoperatorias y sin recurrencias ni cicatrices hipertróficas al año de evolución. Es de interés la publicación por tratarse del primer caso que se informa en el Estado de Eritrea, país en desarrollo del cuerno africano.

  9. Linfangioma quístico axilar gigante del adulto: características de presentación y abordaje quirúrgico

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    A. Navarro-Mancía

    2015-09-01

    Full Text Available Presentamos el abordaje clínico de un caso que se une a los 5 únicos publicados de condición clínica similar encontrados después de una revisión sistemática en la red de información médica en publicaciones disponibles. Se trata de un paciente adulto que presentaba una tumoración quística en la región axilar sin evidencia conocida de causalidad, con crecimiento gradual hasta alcanzar un gran volumen, y asintomática. El diagnóstico final fue de linfangioma quístico axilar gigante. Ante esta entidad clínica, de rara incidencia en la población adulta, es necesaria una cuidadosa planificación de tratamiento a fin de obtener un resultado satisfactorio. Es por ello que lo más relevante del abordaje quirúrgico en nuestro caso fue la necesidad de una disección meticulosa hasta lograr la identificación precisa de los vasos linfáticos aferentes de llenado, su sección y ligadura, para reducir el riesgo de recidiva. Todo lo anterior también se aplica para las tumoraciones de origen linfático congénitas, que son considerablemente más frecuentes en esta región anatómica en comparación con las que se dan en el paciente adulto.

  10. Índice de mortalidad en cultivo del camarón gigante de agua dulce (Macrobrachium rosenbergii en estanques seminaturales en Loreto, Perú

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    Norma Arana Flores

    2013-12-01

    Full Text Available El objetivo del presente trabajo fue evaluar el índice de mortalidad en un cultivo del camarón gigante de agua dulce (Macrobrachium rosenbergii; para ello se acondicionaron 1000 post larvas con peso y longitud promedio de 0,2 g y 2 cm, respectivamente, en un estanque de tierra de 200m2 de espejo de agua, a una densidad de siembra de 5 ind/m2, el alimento suministrado fue de tipo extruzado con 35% PB para el primer mes; posteriormente se suministró una ración con 32% PB hasta el final, la frecuencia alimenticia fue de 3 veces/día los dos primeros meses, reajustándose a 2 veces/día los dos siguientes meses; la tasa alimenticia varió entre 13 y 3,5%; las evaluaciones biométricas se realizaron cada 10 días. Los parámetros limnológicos como temperatura, transparencia, OD, pH, CO2 y dureza se registraron cada 15 días. Los índices de crecimiento aplicados fueron ganancia de peso, ganancia de longitud, ICAA, TCE y supervivencia. Los resultados registran una ganancia en peso y longitud de 27,24 g y 12,37 cm; el incremento de peso y longitud diario en promedio fue de 0,23 g y 0,12cm; ICAA 3,30, TCE 3,59%; sobrevivencia 95%, índice de mortalidad 5%. El análisis limnológico registró variaciones mínimas que no influenciaron negativamente sobre el crecimiento y sobrevivencia de los camarones; la correlación entre el peso y longitud registra una relación positiva, con un nivel de correlación muy buena.

  11. Índice de mortalidad en cultivo del camarón gigante de agua dulce (Macrobrachium rosenbergii en estanques seminaturales en Loreto, Perú

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    Norma Arana Flores

    2013-12-01

    Full Text Available El objetivo del presente trabajo fue evaluar el índice de mortalidad en un cultivo del camarón gigante de agua dulce (Macrobrachium rosenbergii; para ello se acondicionaron 1000 post larvas con peso y longitud promedio de 0,2 g y 2 cm, respectivamente, en un estanque de tierra de 200m2 de espejo de agua, a una densidad de siembra de 5 ind/m2, el alimento suministrado fue de tipo extruzado con 35% PB para el primer mes; posteriormente se suministró una ración con 32% PB hasta el final, la frecuencia alimenticia fue de 3 veces/día los dos primeros meses, reajustándose a 2 veces/día los dos siguientes meses; la tasa alimenticia varió entre 13 y 3,5%; las evaluaciones biométricas se realizaron cada 10 días. Los parámetros limnológicos como temperatura, transparencia, OD, pH, CO2 y dureza se registraron cada 15 días. Los índices de crecimiento aplicados fueron ganancia de peso, ganancia de longitud, ICAA, TCE y supervivencia. Los resultados registran una ganancia en peso y longitud de 27,24 g y 12,37 cm; el incremento de peso y longitud diario en promedio fue de 0,23 g y 0,12cm; ICAA 3,30, TCE 3,59%; sobrevivencia 95%, índice de mortalidad  5%. El análisis limnológico registró variaciones mínimas que no influenciaron negativamente sobre el crecimiento y sobrevivencia de los camarones; la correlación entre el peso y longitud registra una relación positiva, con un nivel de correlación muy buena.

  12. Anemia hemolítica autoinmune en un niño con hepatitis de células gigantes Autoimmune hemolytic anemia in an infant with giant cell hepatitis

    OpenAIRE

    Jessica Gómez; Kathia Valverde

    2012-01-01

    La asociación de anemia hemolítica autoinmune (AHAI) con hepatitis de células gigantes (HCG) es un trastorno raro en la infancia. Son pocos los casos reportados y la gran mayoría fallecen a pesar de transplante hepático. La AHAI usualmente precede el desarrollo de la afección hepática. El diagnóstico temprano de esta asociación y el inicio de terapia inmunosupresora previene la progresión de la enfermedad.Autoimmune hemolytic anemia (AIHA) associated with giant cell hepatitis (GCH) is a rare ...

  13. Anemia hemolítica autoinmune en un niño con hepatitis de células gigantes Autoimmune hemolytic anemia in an infant with giant cell hepatitis

    OpenAIRE

    Jessica Gómez; Kathia Valverde

    2012-01-01

    La asociación de anemia hemolítica autoinmune (AHAI) con hepatitis de células gigantes (HCG) es un trastorno raro en la infancia. Son pocos los casos reportados y la gran mayoría fallecen a pesar de transplante hepático. La AHAI usualmente precede el desarrollo de la afección hepática. El diagnóstico temprano de esta asociación y el inicio de terapia inmunosupresora previene la progresión de la enfermedad.Autoimmune hemolytic anemia (AIHA) associated with giant cell hepatitis (GCH) is a rare ...

  14. Consumo e comportamento ingestivo de caprinos e ovinos alimentados com palma gigante (Opuntia ficus-indica Mill) e palma orelha-de-elefante (Opuntia sp.) - DOI: 10.4025/actascianimsci.v30i2.4684

    OpenAIRE

    Valéria Louro Ribeiro; Mário de Andrade Lira; Adriana Guim; Ângela Maria Vieira Batista; Maria Caroline de Almeida Cavalcanti; Agenor Costa Ribeiro Neto

    2008-01-01

    O presente trabalho teve por objetivo avaliar o consumo e comportamento ingestivo de caprinos e ovinos alimentados com palma Gigante (Opuntia fícus-indica Mill) e palma Orelha-de-elefante (Opuntia sp.). Foram utilizados 20 animais mestiços, sendo dez caprinos e dez ovinos, alojados em galpão coletivo, contidos individualmente por meio de cordas, distribuídos em delineamento inteiramente casualizado, em um arranjo fatorial 2 x 2 (duas espécies animais e duas variedades de palma). As observaçõe...

  15. Miocarditis de células gigantes con bloqueo AV completo persistente: respuesta al tratamiento con resincronizador cardiaco Giant cell myocarditis with complete persistent A-V block: treatment response with cardiac resynchronization

    Directory of Open Access Journals (Sweden)

    Julián Aristizábal

    2009-08-01

    Full Text Available La miocarditis de células gigantes es una enfermedad grave y poco frecuente, cuya etiología, posiblemente autoinmune, se caracteriza por la presencia de células gigantes multinucleadas con infiltrado inflamatorio y necrosis extensa en la biopsia endomiocárdica. Es común su asociación con taquicardias ventriculares y con alteraciones de la conducción aurículo-ventricular, lo cual se resuelve algunas veces con tratamiento inmunosupresor. Dada la complejidad del pronóstico de esta entidad, el papel de los dispositivos de resincronización después de la estabilización de la falla cardíaca, no está claro. Aquí se reporta un caso en el cual el implante de uno de estos dispositivos fue parte fundamental de la terapia y recuperación del paciente.Giant cell myocarditis is an infrequent and serious illness, possibly of autoimmune etiology, characterized by the presence of multinucleated giant cells with inflammatory infiltrate and extensive necrosis in the endomyocardial biopsy. Its association with ventricular tachycardia is common and alterations in atrioventricular conduction are frequently solved through immunosuppressive treatment. Given the generally complex prognosis of this entity, the role of the resynchronization devices after the heart failure stabilization, is unclear. We reported a case in which the implant of one of these devices was a fundamental part of the therapy and patient recovery.

  16. Reconstrucción en linfedema peneano y escrotal secundario a hernia inguinal bilateral gigante Reconstruction in penile and scrotal lymphedema secondary to billateral giant inguinal hernia

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    A. Fernández García

    2009-12-01

    Full Text Available El linfedema peneano y escrotal tiene consecuencias funcionales, estéticas, sociales y psicológicas significativas para el paciente que lo padece. Es una enfermedad infrecuente en los países desarrollados, aunque relativamente prevalente en los países tropicales. Su causa más común es la filariasis, aunque en nuestra práctica diaria se asocia más frecuentemente a cirugía, radioterapia, procesos inflamatorios y neoplásicos. Presentamos un caso singular de linfedema penoescrotal secundario a cirugía por hernia inguinal gigante bilateral que persistía un año después de la intervención. El tratamiento quirúrgico consistió en la exéresis de toda la piel linfedematosa del escroto involucrada y el uso de colgajos de piel escrotal posterior para la cobertura testicular. En un segundo tiempo quirúrgico se llevó a cabo una extirpación total de la piel del pene y del tejido subcutáneo superficial a la fascia de Buck. Empleamos injertos de piel de grosor parcial para cubrir el pene denudado. El resultado estético postoperatorio fue aceptable y los resultados funcionales y psicológicos son satisfactorios para el paciente 3 años después de la cirugía.Lymphedema of the penis and scrotum has important functional, cosmetic, social, psychological consequences for the affected patient. It is a rare disease in the developed countries, although it is relatively frequent in tropical countries. Globally, the most common cause is filariasis, although in our practice it is most frecuently associated to surgery, radiotherapy, inflammatory and neoplasic diseases. We report one rare case of penoscrotal lymphedema due to billateral giant inguinal hernia reconstrction. The lymphedema was persistent one year after the repair of the billateral hernia. The technique of reconstruction consisted of excision of all involved lymphedematous skin of the scrotum, and use of posterior scrotal flaps for testicular coverage. In a second surgical time, a total

  17. Uso de hábitat de nutria gigante Pteronura brasiliensis, a través de rastros indirectos, en la zona de influencia de Puerto Carreño (Vichada-Colombia

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    Sánchez Pedro

    2007-12-01

    Full Text Available La nutria gigante Pteronura brasiliensis es uno de los mayores depredadores de los sistemas acuáticos de la Orinoquia colombiana. En Colombia mantiene la categoría “En peligro” de la IUCN y actualmente la principal amenaza que enfrenta es la degradación de su hábitat. Se realizaron recorridos a pie por orillas de lagunas y caños y recorridos en bote en el cauce principal de segmentos de los ríos Bita y Orinoco. En puntos de muestreo de orilla sistemáticamente elegidos, que corresponden a puntos con ausencia de rastro; y en cada punto donde se encontraron campamentos o madrigueras, se midieron variables del microhábitat que caracterizan la estructura física y la vegetación de la orilla. A partir de índices de abundancia de madrigueras y campamentos y mediante análisis de contingencia para tablas R X C se determinaron uso y preferencias de hábitat y microhábitat de la nutria gigante. Se encontró una preferencia por caños y lagunas
    para la construcción de madrigueras y campamentos. Se observó que la zona de ventanas caracterizada por afloramientos rocosos dentro del río Orinoco es hábitat para nutrias gigantes aunque es atípico según lo registrado en su área de distribución. Madrigueras y campamentos están asociados a orillas con grandes árboles caídos, suelos orgánicos y en menor proporción con sustratos rocosos. En particular las madrigueras están asociadas con sistemas de raíces y barrancos medianos. Es importante la protección de los sistemas acuáticos de esta zona en especial de lagunas, caños y de la zona de ventanas dentro del río Orinoco. El cuidado de las orillas es fundamental para asegurar la permanencia de poblaciones locales de la especie. El estudio reitera la importancia de realizar programas de investigación a largo plazo para profundizar en el conocimiento ecológico de la especie y generar estrategias de manejo y de conservación de los ecosistemas acuáticos en la región.

  18. 晚期妊娠合并巨大子宫肌瘤67例手术处理%Surgical treatment of 67 cases of late pregancy complicated with gigantic uterine leiomyoma

    Institute of Scientific and Technical Information of China (English)

    魏璐; 潘玥; 胡茜

    2011-01-01

    Objective The treatment of late pregnancy complicated with gigantic uterine leiomyoma in cesarean section (CS) was investigated. Methods A retrospective case-control study was done to review the clinical data of pregnancy with gigantic uterine leiomyoma (A group), late preganacy with leiomyoma (B group), late pregnancy without leiomyoma (C group). The age, operation time and blood loss were compared. Results The age, operation time, blood loss,low-lying placenta,abnormal fetal position, neonata weight, the time to use the antibiotic were significantly different between group A and group B and group C (P<0. 05). No significant differences on postoperative inpatient period, neonatal asphyxia, peupariun infection were found between group A and group B and C (P>0. 05). Conclusion Myomectomy of gigantic uterine leiomyoma during CS is feasible, but careful perioperative management is very critical.%目的 探讨晚期妊娠合并巨大子宫肌瘤术中的处理方式.方法 分析晚期妊娠合并巨大子宫肌瘤(A组)、晚期妊娠合并子宫肌瘤(B组)及单纯行剖宫产(C组)患者的临床资料,每组均为67例.对患者年龄、手术时间、术中失血量等指标进行比较.结果 A组的年龄、手术时间、术中失血量、低置胎盘、胎位异常、新生儿体重、抗生素使用时间与B、C组相比有统计学差异(P<0.05),但3组间术后住院时间、新生儿窒息率及产褥感染率无明显差异(P>0.05).结论 剖宫产术中同时处理巨大子宫肌瘤是可行的,但必须根据受术者的个体情况加强围手术期的管理.

  19. 妊娠合并巨大子宫肌瘤17例临床分析%Clinical Analysis of 17 Cases of Pregnancy Complicated with Gigantic Uterine Fibroids

    Institute of Scientific and Technical Information of China (English)

    晋兴林; 花怀珍

    2014-01-01

    0bjective:To explore the management of pregnancy complicated with gigantic uterine fibroids in ce-sarean section.Methods:A retrospective case-control study was done to review the clinical data of 17 cases of preg-nancy with gigantic uterine fibroids (A group),17 cases of pregnancy with fibroids (B group), 17 cases of pregnancy without fibroids (C group).The operation time,blood loss,postpartum hemorrhage,peuparium infection and hospital-ization days were compared.Results:The mean operative time in group A was significantly longer than group B、C (P0.05).Conclusions:Myomectomy of gigantic uterine fibroids during Cesarean section is safe and feasible,but careful perioperative management is very critical.%目的:探讨妊娠合并巨大子宫肌瘤的剖宫产术中的处理方式。方法:选择某医院妊娠合并巨大子宫肌瘤17例(A组)、妊娠合并子宫肌瘤17例(B组)及单纯行剖宫产17例(C组)的患者临床资料进行回顾性分析。对手术时间、术中失血量、产后出血情况、产褥感染率、术后住院天数等指标进行比较。结果:研究组A组的手术时间、术中出血量、产后出血例数明显高于对照组B、C组(P0.05)。结论:剖宫产术中同时处理巨大子宫肌瘤安全、可行,但必须强调整个围手术期管理的重要性。

  20. Nevus melanocítico intradérmico congénito gigante. "El niño tortuga (testudines": Caso clínico Giant congenital melanocytic nevus. "Turtle boy": Case report

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    J.F. Arango Ospina

    2009-09-01

    Full Text Available Presentamos el caso de un paciente de 2 años de edad, conocido en su pueblo, como "el niño tortuga (testudines" debido a la gran similitud con dicho reptil. Desde su nacimiento presentó nevus melanocítico gigante localizado en región torácica posterior, región lumbosacra y lesiones satélites en extremidades y abdomen, de 50 por 40cm de diámetro y color café oscuro; la piel en las zonas afectadas es gruesa con grandes surcos de aspecto corrugado (cerebriforme. El nombre dado al niño se basa en la similitud de sus lesiones con la morfología de una tortuga, ya que el caparazón cubre la zona superior, inferior y lateral del cuerpo de este animal, de la misma forma que el nevus gigante lo hacía en el caso de nuestro paciente. Este caparazón está formado por placas óseas revestidas de placas corneas, que se asemejan a los surcos de aspecto corrugado que conforman el nevus melanocítico gigante. Los estudios clínicos practicados revelaron compromiso cardiovascular, hepático y esplénico, así como una desfavorable evolución y pronostico del cuadro clínico, por lo que esta patología, específicamente para este niño y de acuerdo a la junta Médico-Quirúrgica y valoraciones, fue considerada inoperable.We present the case of a 2 years-old patient, known in his town as "turtle boy"(testudines due to his great simility with this reptile because of his giant congenital melanocytic nevus, located in the posterior and lateral aspect of the chest and in smaller proportion in abdomen and extremities, of 50 by 40cm and dark brown colour. The skin in this zone is thick with great furrows and corrugated aspect. He was called "turtle boy" based on the morphology of the turtle, its shell covers the superior, inferior and lateral zone like in our patient's case. It is formed by bone layers covered by cornea layers, which resemble the furrows and corrugated aspect of the giant congenital melanocytic nevus. Medical investigation reveals

  1. Miofibroblastoma gigante de la mama

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    José Abraham Jaramillo Osorio

    2013-10-01

    Full Text Available ResumenEl miofibroblastoma es una neoplasia rara, inicialmente descrita en hombres y usualmente pequeña. Presentamos un caso de esta lesión, excepcionalmente grande en una mujer. El diagnóstico es posible con técnicas de inmunohistoquímica: S100, citoqueratina, Actina de músculo liso (AML y CD 34. Estos tumores son benignos. El tratamiento consiste en la resección quirúrgica de la lesión. (Duazary 2009 I; 48-50AbstractThe Myofibroblastoma is a uncommon neoplasm, initially informed in men, usually small. We present a case of this lesion, exceptionality large in a woman. The diagnostic is possible with immunohistochemistry techniques: S100, MLA y CD34. These tumors are benign and may be treated by local excision.KeyWords: Breast; Myofibroblastoma; Immunohistochemistry.

  2. Pituitary gigantism causing diabetic ketoacidosis.

    Science.gov (United States)

    Alvi, N S; Kirk, J M

    1999-01-01

    Although growth hormone excess (acromegaly) in association with glucose intolerance and diabetes mellitus is well documented in adult medicine, it is much less common in the paediatric age group. We report the case of a 13 year-old boy who presented with tall stature secondary to a large growth hormone secreting adenoma of the pituitary gland. Random growth hormone was 630 mIU/l and did not suppress during an oral glucose tolerance test. Following debulking of the tumour, he developed diabetic ketoacidosis requiring insulin treatment, but after further surgery glucose handling returned to normal. He has been started on testosterone to arrest further increase in height.

  3. Análisis de los polimorfismos de longitud de los fragmentos de restricción (RFLP del gen ribosómico 18S RNA de nutria gigante de río Pteronura brasiliensis

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    Grupo de Investigación en Genética Molecular

    2001-06-01

    Full Text Available La nutria gigante de río Pteronura brasiliensises un mamífero carnívoro de la familia Mustelidae, ala cual pertenecen también las tairas, las martas y los hurones. La nutria es considerada por elCITES como una especie vulnerable y por la IUCN como especie en peligro de extinción. Por estarazón, el Centro de Biología Molecular del Gimnasio Campestre inicio un proyecto de genética conservacionista que pretende proveer información utilizable para el análisis, tanto de la especieP. brasiliensiscomo de sus familiares mas cercanos, y de esta forma, proponer planes de manejo dela especie y su hábitat previniendo su extinción.

  4. Neumotórax y bulla enfisematosa gigante rota como manifestación inicial de un carcinoma Pneumothorax and ruptured giant emphysematous bulla as a manifestation of carcinoma

    OpenAIRE

    Orestes Noel Mederos Curbelo; Juan Carlos Barrera Ortega; Evelio Guerra Pereda; José Manuel Da Costa Fernández

    2010-01-01

    Se presenta el caso de un paciente de 64 años de edad que acudió al cuerpo de guardia con dolor torácico agudo localizado en hemitórax derecho y disnea intensa. La persistencia del neumotórax sin que se lograra la reexpansión pulmonar con la pleurotomía y el drenaje torácico obligó a una toracotomía. Se encontró una bulla enfisematosa gigante rota, y se realizó una bilobectomía superior y media. El diagnóstico histológico fue carcinoma bronquioalveolar. La coincidencia de un cáncer de pulmón ...

  5. Escisión de un fibroma de células gigantes con láser de diodo: Informe de un caso Excision of a giant cell fibroma with Diodo's Laser: Report of case

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    C.M. Ardila Medina

    2010-06-01

    Full Text Available Este artículo informa un caso de un fibroma gigantocelular localizado en tejido gingival y mucosa oral. Microscópicamente, la lesión se caracterizó por proliferación de fibras colágenas y fibroblastos gigantes, que se disponían en forma densa e irregular. Además, la superficie de la lesión estaba revestida por epitelio con cambios de hiperqueratosis. Se realizó escisión del fibroma con láser de diodo.This article reports a case of giant cell fibroma located in the gingival tissue and oral mucosa. Microscopically, the lesion was characterized by proliferation of collagen fibers and giant fibroblast, irregular and densely arranged. Beside, the surface was covered by epithelium with hiperqueratosis changes. The excision was done with Diodo's Laser.

  6. Determinación parcial del mapa de restricción del DNA mitocondrial de la nutria gigante de río Pteronura brasiliensis y comparación con otros mustélidos colombianos en cautiverio

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    Bernal J.

    2001-06-01

    Full Text Available La nutria gigante de río Pteronura brasiliensises un mamífero carnívoro de la familia Mustelidae, ala cual pertenecen también las tairas y los hurones. La nutria es considerada por el CITES comouna especie vulnerable y por la IUCN como especie en peligro de extinción. Por esta razón, elCentro de Biología Molecular del Gimnasio Campestre inicio un proyecto de genética conser-vacionista que pretende proveer información utilizable para el análisis, tanto de la especieP. brasiliensiscomo de sus familiares mas cercanos, y de esta forma, proponer planes de manejode la especie y su hábitat previniendo su extinción.

  7. Reducción de la aurícula izquierda y reemplazo de válvula mitral mediante técnica de autotransplante en paciente con aurícula izquierda gigante

    OpenAIRE

    Ríos, Josías; Morón, Julio

    2013-01-01

    El 19% de los pacientes con patología mitral reumática presenta aurícula izquierda gigante (diámetro mayor a 65mm), esta patología ha sido asociada con incremento del riesgo de stroke y de muerte súbita. La indicación de reducción auricular se establece cuando existe compresión de las extructuras vecinas, antecedentes de fenómenos tromboembólicos o en pacientes asintomáticos para restablecer el ritmo sinusal (Cirugía de Maze). Se presenta el caso de una mujer de 63 años con estenosis e insufi...

  8. Clinical Analysis of Laparoscopic Hysterectomy for Gigantic Uterus (Report of 178 cases)%178例腹腔镜巨大子宫全切术临床分析

    Institute of Scientific and Technical Information of China (English)

    李玲玲; 岳青芬

    2015-01-01

    目的:探讨巨大子宫经腹腔镜切除的安全性、手术技巧和临床价值。方法分析该院178例行经腹腔镜巨大子宫切除术(子宫跃孕12周)的临床资料。结果所有手术均经腹腔镜完成,无一例手术并发症发生。手术时间院(89.4±31.6)min;出血量院(94.5±48.3)mL。平均住院时间4.8 d。结论经腹腔镜巨大子宫切除术安全可行,但应选好适应症,术者具备较高的腹腔镜操作水平。%Objective To investigate the clinical value and operating techniques of laparoscopic hysterectomy for gigantic uter. Methods 178 patients whose uteris were larger than twelve-weeks pmgnant uteri accepted aparoscopic hysterectomy and their clinical data were analyzed retrospectively. Results All operations were performed successfully under laparoseopy. No operating complication happened in any cases.The operating time was (89.4±31.6)min,blood loss in operation was (94.5±48.3)mL and the average hospitalization time was 4.8 days.Conclusion On the basis of proper indication and good operating techniques of the oper-ators, laparoscopic hysterectomy for gigantic uteri is safe and feasible.

  9. Case study of a 15-year-old boy with McCune-Albright syndrome combined with pituitary gigantism: effect of octreotide-long acting release (LAR) and cabergoline therapy.

    Science.gov (United States)

    Tajima, Toshihiro; Tsubaki, Junko; Ishizu, Katsura; Jo, Wakako; Ishi, Nobuaki; Fujieda, Kenji

    2008-07-01

    The use of octreotide-LAR and cabergoline therapy has shown great promise in adults with acromegaly; however, the experience in pediatric patients has rarely been reported. We described a clinical course of a 15-year-old boy of McCune-Albright syndrome (MAS) with pituitary gigantism. At the age of 8 years, a growth hormone (GH) and prolactin (PRL) producing pituitary adenoma was diagnosed at our hospital. He also had multiple fibrous dysplasia, so that he was diagnosed as having MAS. The tumor was partially resected, and GNAS1 gene mutation (R201C) was identified in affected tissues. We introduced octreotide to suppress GH secretion (100 mug 2/day s.c). During therapy with octreotide, IGF-1 and GH levels could not be suppressed and the patient frequently complained of nausea from octreotide treatment. Therefore, the therapy was changed to monthly injections of octreotide-LAR at the age of 12.3 years and was partially effective. However, as defect of left visual field worsened due to progressive left optic canal stenosis, he underwent second neurological decompression of the left optic nerve at 13.4 years of age. After surgery, in addition to octreotide-LAR, cabergoline (0.25 mg twice a month) was started. This regimen normalized serum levels of GH and IGF-1; however, he showed impaired glucose tolerance and gallstones at 15.7 years of age. Therefore, the dose of octreotide-LAR was reduced to 10 mg and the dose of cabergoline increased. This case demonstrated the difficulty of treating pituitary gigantism due to MAS. The use of octreotide-LAR and cabergoline should be considered even in pediatric patients; however, adverse events due to octreotide-LAR must be carefully examined.

  10. Tumor de células gigantes da extremidade distal do fêmur: um desafio de tratamento Giant cell tumor of femoral distal end: a challenge in treatment

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    Suraj Bajracharya

    2009-01-01

    Full Text Available Apresentamos aqui um caso de tumor de células gigantes na extremidade distal do fêmur direito tratado com ressecção da massa tumoral em bloco com remoção aguda da extremidade proximal e distal e fixado com hastes longas em K atravessando o joelho, do fêmur à tíbia. Após a consolidação / união completa das extremidades, foi feita a remoção da haste em K, seguida pela corticotomia juntamente com a osteogênese da distração com o auxílio do anel fixador de Ilizarov. O comprimento foi alcançado com este processo. O resultado final foi muito bom neste caso. Revisamos as opções de tratamento para tumor maligno de células gigantes na extremidade distal do fêmur e as dificuldades de tratá-lo.We present a case of malignant giant cell tumor of distal end of right femur treated with resection of the tumor mass en block with acute docking of proximal and distal end and fixed with long K-nail across knee from femur to tibia. After complete consolidation/ union of the ends, removal of K nail was done followed by corticotomy along with distraction osteogenesis with the help of Ilizarov ring fixator. The length was achieved with this process. The end result was very good in this case. We reviewed the treatment options for malignant giant cell tumor of femoral distal end and the challenges in its treatment.

  11. Anemia hemolítica autoinmune en un niño con hepatitis de células gigantes Autoimmune hemolytic anemia in an infant with giant cell hepatitis

    Directory of Open Access Journals (Sweden)

    Jessica Gómez

    2012-12-01

    Full Text Available La asociación de anemia hemolítica autoinmune (AHAI con hepatitis de células gigantes (HCG es un trastorno raro en la infancia. Son pocos los casos reportados y la gran mayoría fallecen a pesar de transplante hepático. La AHAI usualmente precede el desarrollo de la afección hepática. El diagnóstico temprano de esta asociación y el inicio de terapia inmunosupresora previene la progresión de la enfermedad.Autoimmune hemolytic anemia (AIHA associated with giant cell hepatitis (GCH is a rare disorder in infants. Few cases have been reported and despite receiving a liver transplant, there is high mortality among patients. AIHA usually precedes the development of liver disease. Early recognition of this association and the administration of immunosuppressive therapy prevent progression of the disease. Keywords: Autoimmune hemolytic anemia, giant cell hepatitis La asociación de anemia hemolítica autoinmune (AHAI con hepatitis de células gigantes (HCG es un trastorno raro en la infancia. Son pocos los casos reportados y la gran mayoría fallecen por fallo hepático, a pesar de trasplante. La AHAI suele preceder el desarrollo de la afección hepática. El diagnóstico temprano de esta asociación y el inicio de terapia inmunosupresora evitan la progresión de la enfermedad. Se reporta un niño de 1 año de edad al que se le diagnosticó AHAI al mes y medio de edad y luego desarrolló HCG. Para su manejo, ameritó terapia inmunosupresora con corticoesteroides, inmunoglobulina intravenosa, anticuerpo monoclonal anti-CD20 (Rituximab y, además, plasmeferésis.

  12. Expressão imuno-histoquímica da vimentina e do HHF-35 em fibroma de células gigantes, hiperplasia fibrosa e fibroma da mucosa oral Immunohistochemical expression of vimentin and HHF-35 in giant cell fibroma, fibrous hyperplasia and fibroma of the oral mucosa

    Directory of Open Access Journals (Sweden)

    Márcia Cristina da Costa Miguel

    2003-03-01

    Full Text Available O fibroma de células gigantes, a hiperplasia fibrosa e o fibroma constituem algumas das mais freqüentes lesões fibrosas orais, compartilhando características clínicas e histopatológicas. Este estudo teve o objetivo de investigar a imunorreatividade das células gigantes estreladas mono, bi ou multinucleadas, características do fibroma de células gigantes e, ocasionalmente presentes na hiperplasia fibrosa e no fibroma, a anticorpos anti-vimentina e anti-actina de músculo (HHF-35, visando detectar características fenotípicas destas células. Os resultados demonstraram que na maioria dos casos houve imunorreatividade para a vimentina, sugerindo um fenótipo fibroblástico para estas células.The giant cell fibroma, fibrous hyperplasia and fibroma are the most frequent fibrous oral lesions, sharing clinical and histopathological features. The purpose of this study was to investigate the immunoreactivity of the large stellate-shaped mononuclear and multinucleated cells, reported as the most characteristic histological feature of the giant cell fibroma but present occasionally in fibrous hyperplasia and fibroma, for the antibodies vimentin and HHF-35 in order to detect phenotypical characteristic of these cells. The results showed in the most of cases positive staining for vimentin, suggesting a fibroblast phenotype for these cells.

  13. 棒球缝合法在腹腔镜下巨大子宫肌瘤剥除术中的应用%Application of baseball suture in laparoscopic myomectomy for gigantic hysteromyoma

    Institute of Scientific and Technical Information of China (English)

    干晓琴; 刘江; 林海; 张凌; 张强; 黄利琼; 张家佳

    2016-01-01

    Objective To observe the clinical effect of the baseball suture in laparoscopic myomectomy for gigantic hysteromy-oma.Methods Ninety-six patients with gigantic hysteromyoma undergoing laparoscopic myomectomy at our department from January, 2013 to December,2015 were randomly divided into research group ( using Lin's baseball suture) and control group ( with classical con-tinuous suture) ,48 cases in each group.The suture time,whole operation time,intraoperative blood loss,postoperative complications and hospital stay were compared between the two groups.Results The average intraoperative blood loss in the research group was signifi-cantly lower than that in the control group (P0.05).No postoperative complications happened in the both groups.Conclusion In laparoscopic myomectomy for gigantic hysteromyoma,baseball suture can reduce the intraoperative blood loss.Therefore,it is a very good method for clinical application.%目的:观察棒球缝合法在腹腔镜下巨大子宫肌瘤剥除术中的应用效果。方法将2013年01月至2015年12月在成都市妇女儿童中心医院妇科接受腹腔镜下巨大子宫肌瘤剥除术的患者96例,采用随机数字表法分为研究组(采用棒球缝合法)和对照组(采用传统连续扣锁缝合法),每组48例,比较两组子宫肌瘤剥除创面缝合时间、手术总时间、术中出血量、住院天数及术后并发症情况。结果研究组患者术中出血量明显低于对照组,差异有统计学意义( P<0.05);两组术中缝合肌瘤剥除创面时间、手术总时间、术后住院天数比较,差异无统计学意义( P>0.05)。两组患者均无术中术后并发症发生。结论在腹腔镜下巨大子宫肌瘤剥除术中采用棒球缝合法可以减少术中出血量,是一种值得临床应用的好方法。

  14. Drainage therapy for gigantic cystic lesions of the jaw%开窗减压术治疗颌骨巨大囊性病变的临床研究

    Institute of Scientific and Technical Information of China (English)

    辛俊彤; 袁荣涛; 卜令学; 贾暮云; 李宁毅

    2011-01-01

    Objective To study the drainage therapy for giganlic cyslic lesions of the jaw. Methods Seven palienls with giganlic cyslic lesions of the jaw in the Deplarlmenl of Oral and Maxillofacial Surgery of the Affiliated Hospital of Medical College in Qingdao U niversily were examnined wilh drainage iherapy from August,2006 to April,2009. They were evaluated wilh a preoperalive panoramic photography and CT. Second operation was taken while the cavity became narrow and small. The left cystic lesion tissue was obtained for pathological examination. Results Six cases with gigantic cystic lesions of the jaw were cured with drainage therapy in an average peri od of 15. 7 months,from five months to twenty-six months. There was no recurrence after one year's follow-up. One case with dentigerous cyst failed with drainage therapy,and then was taken curettage. The cyst wall was found thicker than other cases. Conclusions Drain age therapy was an ideal minimally invasive surgery therapy for gigantic cystic lesions of the jaw. The mechanisms need more studies.%目的 研究开窗减压术治疗颌骨巨大囊性病变.方法 选取7例颌骨巨大囊性病变病例,术前均行X线和CT检查,行开窗减压术治疗.对其治疗前后影像学表现、组织病理学变化进行研究.结果 6例颌骨巨大囊性病变病例,经开窗减压治疗后,囊腔消退,二期手术刮除残余囊壁,随诊1年无复发,平均病程15.7月.另1例含牙囊肿治疗无效,行刮除术.结论 开窗减压术是一种理想的颌骨巨大囊性病变的微创功能治疗方法,其内在的机制尚需进一步研究.

  15. SOME ASPECTS OF EARLY DEVELOPMENT OF THE THYMUS: EMBRYOLOGICAL BASIS FOR ECTOPIC THYMUS AND THYMOPHARYNGEAL DUCT CYST. Algunas observaciones acerca del temprano desarrollo del timo: bases embriológicas del timo ectópico y del quiste del conducto timofar

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    Ivan Varga

    2016-03-01

    Full Text Available Introducción. El objetivo principal de nuestro trabajo es el estudio histológico del desarrollo del timo humano entre la 5ª y la 8ª semana de gestación. Describimos varios términos embriológicos poco usados como: timo secundus, descensus thymi (la base embriológica para situar el timo en la garganta, ductus timicus (la base embriológica para el defecto innato llamado conducto timofaríngeo con posibilidad de formar un quiste. Material y método. Nuestras observaciones se basan en la investigación de 18 embriones humanos entre la 6ª y la 8ª semana de gestación. Resultados. La base del timo es común con la base de las glándulas paratiroideas. Es comparable con las bolsas faríngeas (saccus pharyngeus en los embriones largos de 8 a 9 mm. La proliferación endodermal del epitelio en el tercer foco faríngeo (focus faringeus 3 es muy visible. La parte craneal y la parte dorsal son la base de origen de las glándulas paratiroideas inferiores. La parte caudal y la parte ventral son la base para el timo. Hemos observado también la notable proliferación del epitelio en la segunda bolsa faríngea, llamado por algunos autores Timo secundus. En nuestra opinión, en el ser humano no se forma un timo funcional en este lugar y la proliferación del epitelio en la mayoría de los casos, se detiene pronto. Conclusión. En este trabajo ofrecemos una vista general sobre la importancia clínica del desarrollo del timo y la descripción de los defectos innatos más frecuentes del mismo. Introduction. The aim of our morphological study is to describe the development of human thymus from 5th up to 8th week after fertilization in the context of its phylogenesis. We explicate some of the “forgotten” embryological terms with respect to their functions in thymic development, such as “thymus secundus”, “descensus thymi” (an embryological basis for cervical thymus and “ductus thymicus” (an embryologic basis for a congenital anomaly called

  16. 大型工程建设项目对血吸虫病传播流行的影响%IMPACT OF GIGANTIC ENGINEERING CONSTRUCTION PROJECTS ON TRANSMISSION AND PREVALENCE OF SCHISTOSOMIASIS

    Institute of Scientific and Technical Information of China (English)

    谢娟; 闻礼永

    2015-01-01

    This article examined the influence on the distribution of Ocomelania, the middle-host of schistosome, the changing by ecological environment, resulted from key engineering construction projects such as water conservancy engineering construction project, wetland engineering construction project and agricultural engineering construction projects. An analysis to the potential risk factors such as the spread of snails and new breeding grounds of snail, caused by all kinds of engineering construction.This paper reviews and discusses how to use the advantage of gigantic engineering construction projects to promote schistosomiasis prevention and control work.%本文综述了我国水利工程、湿地、农业等一系列重大工程建设所引起生态环境变化对血吸虫唯一中间宿主钉螺分布扩散的影响,分析了各工程建设可能导致钉螺扩散,形成新的钉螺孳生地等潜在危险因素,并就如何利用工程建设趋利避害促进血吸虫病防治工作进行了探讨。

  17. PEG模拟干旱胁迫对巨紫荆种子萌发及生长生理的影响%Effects of PEG simulated drought stress on seed germination and growth physiology of Cercis gigante

    Institute of Scientific and Technical Information of China (English)

    凌敏; 杨秀莲; 王良桂

    2015-01-01

    The purpose of this study was to understand the drought tolerance of Cercis gigante seed in germination stage. The seeds were soaked at 80℃ hot water for 12h,then treated with 150 mg/L gibberellin for 12h,and finally stratified at low temperature for one month. After dormancy breaking, the seeds of Cercis gigante seeds were germinated on filter paper in Petri dish gauze under different concentration of PEG solution. Effects of drought stress on seed germination per⁃centage, seedling growth, protective enzyme activity and organic osmoregulation substances were studied.A regression a⁃nalysis was conducted between PEG concentration and the germination rate , radicle length and so on . Results showed that:① Under PEG stress, the seed germination rate, germination index, vigor index, radicle and hypocotyl length showed a trend of rising first and then decline with the aggravating of drought stress,indicating that low concentration (5%) of PEG could promote the seeds germination and growth, whereas high concentrations (10%,20%, 30%) had the inhibition effects.②With the increase of PEG concentration, contents of three kinds of organic regulation substances ( soluble sugar, soluble protein and free proline) and SOD activity in Cercis gigante seedsall showed a trend of decline first and then rising.POD activity showed a trend of rising first and then decline.Thus it could be seen that the drought tolerance of Cercis gigante seeds could be improved by increasing protective enzyme activities and contents of osmotic regulation substances, making the inhibition degree to the minimum.%为研究巨紫荆种子萌发期对水分胁迫的耐受性,以80℃热水处理12 h,150 mg/L赤霉素浸种12 h,低温沙藏1个月,打破休眠后的巨紫荆种子为材料,采用培养皿纱布滤纸萌发的方法研究了不同浓度聚乙二醇( PEG)溶液对其种子萌发、生长、保护酶活性和有机渗透调节物质含量的影响,并对种子的萌

  18. Influência da baixa temperatura ambiental sobre a inflamação em rã-touro gigante (Rana catesbeiana: avaliações qualitativa e quantitativa

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    José Luiz Catão-Dias

    1999-01-01

    Full Text Available O presente trabalho teve por objetivo investigar a modulação exercida pela temperatura ambiental sobre a cinética celular inflamatória experimentalmente induzida em Rana catesbeiana, rã-touro gigante. Para tanto, 120 espécimes pós-metamórficos foram mantidos a 6ºC e 24ºC e tratados pela transfixação do tecido muscular da coxa por fio de sutura ou injeção intramuscular de carragenina. Os resultados obtidos através de avaliações qualitativa e quantitativa do foco lesional mostraram que a baixa temperatura ambiental modula significativamente a evolução do processo inflamatório. Animais mantidos a 6ºC, em ambos os modelos, apresentaram números de células inflamatórias significativamente menores que os verificados a 24ºC, independentemente do tempo de avaliação. Por outro lado, algum fator pertencente aos mecanismos de defesa do hospedeiro não deve ter sido bloqueado pela temperatura, visto que a área de reação à injúria mostrou-se equivalente na maioria dos tempos pesquisados.

  19. Primer caso en México y América Latina de linfoma anaplásico de células gigantes en paciente con implantes mamarios

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    Cesar Torres-Rivero

    Full Text Available El Linfoma Anaplásico de Células Gigantes (LACG asociado a implantes mamarios es una patología poco frecuente. Desde el primer caso publicado en la década de los noventa, en los últimos años hemos observado un mayor número de casos recogidos en la literatura. Si bien se tiene información de aproximadamente 90 casos publicados en el mundo, algunos autores mencionan la posibilidad de que existan más de 100 o 200 casos, por lo que su presencia ha suscitado mucha controversia, si bien en general se sigue considerando una patología infrecuente. Hasta donde hemos podido conocer, presentamos el primer caso de LACG documentado por un cirujano plástico en México y América Latina, en una mujer de 43 años de edad portadora de implantes mamarios, con historia de asimetría mamaria unilateral por seroma tardío, y en la que tras 2 punciones sin mejoría de la sintomatología se realizó retirada del implante y capsulectomía, confirmando en líquido periprotésico la presencia del LACG.

  20. Quiste dentígero en seno maxilar

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    Enrique Pérez Figueredo

    2015-01-01

    Full Text Available El seno maxilar está presente como una pequeña cavidad desde el nacimiento y comienza su desarrollo durante el tercer mes de vida intrauterina, alcanzando su máximo desarrollo alrededor de los 18 años, la evolución del seno tiene relación con la cronología. Pueden existir patologías y procesos tumorales, visibles o no a través de radiografías convencionales, que se desarrollen en él. Ello está determinado por la superposición de estructuras anatómicas existentes en el cráneo, por lo que se puede utilizar en estos estudios la tomografía axial computarizada. Se presenta el caso de un paciente de 50 años de edad, que presentó aumento de volumen a nivel del seno maxilar izquierdo. En el examen intraoral se observó la ausencia de los dientes 18 y 28. Durante el estudio radiológico se pudo constatar la radiopacidad en el seno maxilar derecho y la más acentuada en el izquierdo. Mediante la tomografía axial computarizada se determinó la presencia de ambos dientes, 18 y 28, involucrados en ambos senos maxilares. Los resultados demostraron que la evaluación clínica, unida al empleo de la tomografía axial computarizada, constituye métodos eficaces para el diagnóstico de patologías y presencia de dientes retenidos en los senos maxilares

  1. Quiste dentígero en seno maxilar

    OpenAIRE

    Enrique Pérez Figueredo; Víctor Chávez Guerra; Erótida Pérez Figueredo

    2015-01-01

    El seno maxilar está presente como una pequeña cavidad desde el nacimiento y comienza su desarrollo durante el tercer mes de vida intrauterina, alcanzando su máximo desarrollo alrededor de los 18 años, la evolución del seno tiene relación con la cronología. Pueden existir patologías y procesos tumorales, visibles o no a través de radiografías convencionales, que se desarrollen en él. Ello está determinado por la superposición de estructuras anatómicas existentes en el cráneo, por lo que se pu...

  2. Estudio de la prevalencia de quistes foliculares en dientes supernumerarios.

    OpenAIRE

    Ferrés Padró, Eduard

    2008-01-01

    Entre las alteraciones del desarrollo normal de la región oral y maxilofacial se encuentran , las del número de los dientes, tanto en dentición temporal como en dentición permanente: agenesias dentales y dientes supernumerarios.Los dientes supernumerarios son una alteración de la odontogénesis poco frecuente y se define como la presencia de un número de dientes superior a la fórmula dental normal: hiperodoncia.Dependiendo de la morfología, número y localización de los dientes supernumerarios ...

  3. Estudio de la prevalencia de quistes foliculares en dientes supernumerarios.

    OpenAIRE

    Ferrés Padró, Eduard

    2008-01-01

    Entre las alteraciones del desarrollo normal de la región oral y maxilofacial se encuentran , las del número de los dientes, tanto en dentición temporal como en dentición permanente: agenesias dentales y dientes supernumerarios.Los dientes supernumerarios son una alteración de la odontogénesis poco frecuente y se define como la presencia de un número de dientes superior a la fórmula dental normal: hiperodoncia.Dependiendo de la morfología, número y localización de los dientes supernumerarios ...

  4. Fitorremediação de solo contaminado com picloram por capim-pé-de-galinha-gigante (Eleusine coracana Phytoremediation of picloram-contaminated soil by Eleusine coracana

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    Sergio de Oliveira Procópio

    2008-12-01

    Full Text Available O longo efeito residual do herbicida picloram no solo aumenta o risco de lixiviação e de fitotoxicidade em culturas sucedâneas; sua presença no solo pode ser abreviada com o uso da fitorremediação. O objetivo deste trabalho foi avaliar a influência da densidade populacional de capim-pé-de-galinha-gigante (Eleusine coracana sobre a fitorremediação de solo contaminado com o herbicida picloram. O experimento foi realizado em casa de vegetação localizada no município de Rio Verde-GO, no período de setembro de 2006 a fevereiro de 2007. Os tratamentos foram compostos pela combinação entre quatro densidades populacionais da espécie vegetal Eleusine coracana (capim-pé-de-galinha-gigante (0, 7, 14 e 21 plantas por vaso, correspondendo a 0, 172, 344 e 516 plantas m-2, respectivamente e três doses do picloram (0, 80 e 160 g ha-1 - aplicadas diretamente nos vasos, simulando níveis de contaminação do solo. Após o cultivo da espécie vegetal fitorremediadora no substrato por 100 dias, efetuou-se, no próprio vaso, a semeadura da soja (Glycine max L., espécie utilizada como bioindicadora da presença do picloram. A espécie Eleusine coracana mostrou ter capacidade de remediar solos contaminados com o herbicida picloram. A partir de 172 plantas m-2, aumentos na densidade populacional da espécie fitorremediadora não proporcionaram redução de carryover do herbicida picloram sobre a cultura da soja semeada em sucessão.The long-term residual effect of the herbicide picloram poses risks of leaching and phytotoxicity to successive crops. Phytoremediation can abbreviate the long carryover effect. This research was carried out from September 2006 to February 2007, under green house conditions, in Rio Verde, Goiás, Brazil, to study the influence of Eleusine coracana population density on phytoremediation of soil contaminated with picloram. The treatments consisted of the combination of four Eleusine coracana population densities (0, 7, 14

  5. Produção de fitomassa e acúmulo de nutrientes na parte aérea do sorgo de Guiné gigante Biomass production and accumulation of nutrients in shoots of Giant Guinea sorghum plants

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    Gustavo Pavan Mateus

    2011-12-01

    Full Text Available A escolha de espécies com elevada produção de fitomassa para utilização como plantas de cobertura no sistema de semeadura direta é extremamente importante em regiões de inverno seco. O objetivo deste trabalho foi avaliar a produção de fitomassa e acúmulo de nutrientes na parte aérea das plantas de sorgo Guiné gigante (Sorghum bicolor subespécie bicolor raça guinea, semeados em diferentes épocas de semeadura. Foi utilizado um delineamento em blocos ao acaso, com seis tratamentos e quatro repetições. Os tratamentos foram constituídos por seis épocas de semeadura (25/09/2000; 25/10/2000; 24/11/2000; 22/12/2000; 22/02/2001 e 03/04/2001. Por ocasião do florescimento das plantas, avaliou-se a produção de matéria seca, o número e diâmetro de colmos e a altura das plantas. Também foi determinado o teor e acúmulo de macro e micronutrientes, além da relação C/N. O ciclo das plantas diminuiu com o atraso da época de semeadura, e, conseqüentemente, a produção de matéria seca e a relação C/N também foram menores. Comportamento contrário foi observado para o teor de nutrientes. O sorgo de Guiné gigante é sensível ao fotoperíodo e, portanto, semeaduras mais tardias ocasionam diminuição do crescimento das plantas, produção de biomassa e acúmulo de nutrientes. Esta espécie consiste em uma boa opção para cultivo como planta de cobertura no sistema de semeadura direta devido a alta produção de fitomassa e ciclagem de N, P e K.Choosing species with high phytomass production to be cropped in no tillage system is extremely important in dry winter regions. The purpose of this research was to study plant biomass production and accumulation of nutrients in shoots of Giant Guinea sorghum plants (Sorghum bicolor subspecies bicolor race Guinea sown in different sowing dates. A randomized complete block design with six treatments and four replications was performed. Treatments consisted of six sowing dates (09/25/2000; 10

  6. McCune-Albright syndrome combined with gigantism: clinical characteristics and long-term follow-up%McCune-Albright综合征伴巨人症临床特点及长期随访研究

    Institute of Scientific and Technical Information of China (English)

    许岭翎; 朱惠娟; 李梅; 王鸥; 姜艳; 张化冰; 柴晓峰; 冯凯; 李乃适

    2014-01-01

    Objective To investigate the clinical characteristics,causes of disease and responses to treatment in McCuneAlbright syndrome patients combined with gigantism.Methods Long-term follow-up were performed on two cases of McCune-Albright syndrome combined with gigantism,and in combination with literatures the clinical characteristics were analyzed and discussed.Results Both patients underwent neuronavigator assisted transsphenoidal resection of pituitary tumor.After operation,the levels of GH and IGF-1 were significantly decreased.In case 2,GH and IGF-1 levels returned to normal without recurrence during 3-year follow-up.In case 1,treatment of bromocriptine and long-acting somatostatin were performed;growth was notably inhibited and the levels of GH and IGF-1 were significantly decreased.Both patients received bisphosphonate therapy,and bone lesion progression was effectively controlled.Both patients were diagnosed with hypogonadism at the follow-up.Conclusion Treatment of this disease is a long procedure.Clinician should select individualized and comprehensive treatment measures according to the characteristics of patients.Neuronavigation in transsphenoidal resection of pituitary adenoma operation,long-acting somatostatin and bisphosphonate therapy are important measures to control the disease.%目的 探讨伴有巨人症的McCune-Albright综合征患者的临床特点、病程以及对治疗的反应.方法 长期随访北京协和医院收治的2例伴有巨人症的McCune-Albright综合征患者的临床治疗及实验室检查情况.结果 2例患者均接受了神经导航下经蝶入路垂体瘤切除手术,术后生长激素(GH)、胰岛素样生长因子-1(IGF-1)均明显下降,其中例2完全降至正常,随诊3年未见垂体瘤复发迹象;例1术后接受了溴隐亭和长效生长抑素的治疗,生长速度明显降低,GH和IGF-1下降.2例患者均接受了双膦酸盐治疗,骨骼病变进展均得到了有效控制.2例患者均在病程中出现

  7. Fitorremediação de solo contaminado com o herbicida picloram por plantas de capim pé de galinha gigante Phytoremediation of soil contaminated with picloram by Eleusine coracana

    Directory of Open Access Journals (Sweden)

    Renato L. de Assis

    2010-11-01

    Full Text Available Objetivou-se, com este trabalho, avaliar a influência de diferentes lâminas de água no solo sobre a fitorremediação de solo contaminado com o herbicida picloram por plantas de capim pé de galinha gigante (Eleusine coracana. O experimento foi conduzido em casa de vegetação com a utilização de amostras de solo de um Latossolo Vermelho distroférrico. Os tratamentos foram compostos pela combinação de quatro níveis diários de reposição da água, através das lâminas de água evaporada (80, 90, 100 e 110% da lâmina de água evaporada e de três doses do picloram (0, 80 e 160 g ha-1, com quatro repetições. Após 48 h da aplicação do herbicida foi realizada a semeadura do capim pé de galinha gigante. Decorridos 90 dias da emergência, ocorreram a dessecação das plantas e o corte na altura do coleto; em seguida, efetuou-se a semeadura com soja (Glycine max L., cultivar Monsoy 6101, espécie considerada, pela literatura, bioindicadora da presença do picloram. Os resultados obtidos indicaram que a maior lâmina de reposição de água evaporada do solo auxilia na remediação de solos contaminados com o herbicida picloram, utilizando-se plantas de E. coracana. A melhoria da fitorremediação foi significativa apenas quando a contaminação do solo com o herbicida foi de 80 g ha-1.This study aimed to evaluate the influence of different water depths in the soil on phytoremediation of soil contaminated with picloram by Eleusine coracana plants. The experiment was carried out under greenhouse conditions with samples of Oxisol. The treatments consisted of the combination of four daily levels of water replacement (80, 90, 100 and 110% of evaporated water and three picloram rates (0, 80 and 160 g ha-1, arranged in a completely randomized design, in a factorial scheme 4 x 3, with four replications. The phytoremediation specie was sowed 48 h after applying the herbicide. At 90 days post emergence, the plants were desiccated and cut and

  8. Parâmetros morfométricos e biológicos de populações monoclonais e multiclonais do pulgão-gigante-do-pinus

    Directory of Open Access Journals (Sweden)

    Susete do Rocio Chiarello Penteado

    2017-01-01

    Full Text Available O pulgão-gigante-do-pinus, Cinara atlantica, originário da América do Norte, foi introduzido no Brasil na década de 1990 e encontra-se amplamente distribuído nos plantios comerciais de pínus. Este estudo teve como objetivo correlacionar os parâmetros morfométricos de insetos oriundos de colônias mono e multiclonais de C. atlantica com seu desempenho reprodutivo em mudas de viveiros comerciais e em progênies de Pinus taeda. Foi registrado o número de ninfas produzidas fêmea dia-1. Após a morte destas fêmeas, foram realizadas medições dos caracteres morfológicos, utilizando o programa, Axion Vision 4,5. O comprimento da tíbia, fêmur posterior e antena foram os parâmetros morfométricos que apresentaram maior correlação com o comprimento do corpo dos insetos, representando 98% da variação total. Com os valores destas variáveis foi criada uma nova variável, denominada “tamanho do inseto”, que foi utilizada para comparação dos tratamentos. Os insetos de colônias multiclonais apresentaram os maiores valores para a maioria dos parâmetros morfométricos e maior produção de descendentes. Insetos maiores e maior produção de ninfas foram observados em mudas originárias dos viveiros comerciais, sugerindo que as progênies estudadas podem apresentar algum fator de resistência que as torna candidatas para uso em programas de manejo integrado desta praga.

  9. Tumor de células gigantes em falange proximal com metástase pulmonar: relato de caso e revisão de literatura Giant cell tumor in proximal phalanx with pulmonary metastasis: case report and literature review

    Directory of Open Access Journals (Sweden)

    Frederico Carvalho de Medeiros

    2011-04-01

    Full Text Available Trata-se de um relato de caso de tumor de células gigantes (TCG em falange proximal de terceiro dedo da mão esquerda com metástase pulmonar. A paciente apresentava dor no dedo sem história prévia de trauma. Foram realizados exame clínico, estudo radiográfico e ressonância nuclear magnética. Feito o estudo histológico, a partir de biópsia incisional, com hipótese de TCG. Foi submetida à amputação do dedo, confirmando o diagnóstico pela microscopia da peça. A paciente foi acompanhada devido ao risco de metástase pulmonar, evidenciada em estudo radiográfico e tomografia computadorizada de tórax, sendo submetida à toracotomia. Desde então, houve melhora dos sintomas referidos no pré-operatório e ausência de recidiva local e novas metástases.This is a case report on a giant cell tumor in the proximal phalanx of the third finger of the left hand, with pulmonary metastasis. The patient presented pain in the finger without any previous history of trauma. Clinical examination, radiographic imaging and magnetic resonance imaging were carried out. A histological evaluation was done from an incisional biopsy, taking the hypothesis of giant cell tumor. The patient underwent amputation of the finger and the diagnosis was confirmed by means of microscopy on the specimen. The patient was followed up because of the risk of lung metastasis, which was shown by radiographic examination and computed tomography on the chest, and thoracotomy was performed. Since then, there has been an improvement of the symptoms that had been reported preoperatively, and no local recurrence or new metastasis has been found.

  10. Variación del volumen espiratorio forzado y presión de oxígeno en reducción del volumen pulmonar en bullas gigantes unilaterales

    Directory of Open Access Journals (Sweden)

    Orestes N Mederos Curbelo

    2002-12-01

    Full Text Available Se presentan 15 enfermos con bullas enfisematosas gigantes, tratados mediante lobectomía reglada en el Hospital Universitario "Comandante Manuel Fajardo", en el período de 1995 a 2000; todos estos pacientes se abordaron mediante incisiones axilares y en el 100 % eran del sexo masculino fumadores de 2 cajetillas de cigarros diarios. La mortalidad quirúrgica fue del 6,6 % a causa de que uno de los pacientes falleció por trombolismo pulmonar. En los 14 enfermos restantes se valoraron las pruebas funcionales respiratorias y se observó un cambio del volumen espiratorio forzado de disminución del volumen residual. En la gasometría arterial, la presión de oxígeno (PO2 aumentó en todos los enfermos hasta valores entre 80 y 85 lo que les permitió incorporarse a su vida laboral activa15 patients with giant emphysematous bullas treated by ruled lobectomy at Comandante Manuel Fajardo Teaching Hospital, from 1995 to 2000, were presented. All these patients were approached by axillary incisions. 100 % were males who smoked 2 packages of cigarettes daily. Surgical mortality was 6.6 % due to the fact that one of the patients died from pulmonary trombolism. In the other 14 patients the functional respiratory tests were made and it was observed a change of the forced expiratory volume in the reduction of the residual volume. In the arterial gasometry, the oxygen pressure (02P increased in all patients, reaching values between 80 and 85, which allowed them to incorporate to their active working life

  11. REMOTE SENSING RESEARCH ON DAGUANGBAO GIGANTIC ROCKSLIDE TRIGGERED BY WENCHUAN EARTHQUAKE%汶川地震触发大光包巨型滑坡遥感研究

    Institute of Scientific and Technical Information of China (English)

    殷跃平; 成余粮; 王军; 王猛; 刘彬; 宋云; 梁京涛

    2011-01-01

    大光包滑坡位于四川省安县高川乡,是汶川Ms8.0级地震触发的规模最大的巨型滑坡.本文采用震前和震后高分辨率遥感数据源,对大光包滑坡滑动前后进行了4期遥感图像对比解译和分析,结合现场调查和地面测绘,对滑坡分区、滑面形态、剪出口位置及滑坡体体积进行了初步研究.将滑坡划分为滑源区、滑坡洼地区、主滑体堆积区、下游堆积区、上游堆积区和前缘堆积区,其中,主滑坡堆积区基本保持了母岩原有结构形态,其岩层产状与基岩大体一致,未明显解体,出露长1100m,宽490m,平均厚215m,体积达4.64×109m3.对比了滑动前后的地形、地貌,以及原矿硐、矿渣、工棚等的位置变化,确定了滑坡边界、滑动方向,滑动距离达1.75km.本文建立了大光包滑坡区1:5000地面数字高程模型(DEM),获得了滑坡堆积区平面分布面积及最大堆积厚度,采用AutoCAD软件分别建立了大光包滑坡滑动前后及滑面的三维实体模型,计算出大光包滑坡最大纵长约4.3km,横宽约3.5km,最大厚度约550m,体积约为11.52~ 11.99×109m3,不仅是我国,也是全球近百年来发生的规模最大的滑坡之一.%The Daguangbao gigantic rockslide is located on the Gaochuan village, Anxia county. It is the hugest landslide triggered by the Wenchuan 8. 0 earthquake on May 12 of 2008. This paper uses four periods of remote sensing data with high resolution before/after the earthquake and ground surveying and mapping data to analyze the basic features of the Daguangbao rockslide. The basic features include the accumulation and movement zoning,the sliding surface and exiting, and the volume. The Daguangbao gigantic rockslide is classified into sliding source, back depression, main bedrock accumulation, down-stream accumulation, up - stream accumulation and front lobe. The main bedrock accumulation remained a structure of parent layered limestone rockmass with slight separation

  12. Granuloma periférico de células gigantes: análisis inmunohistoquímico de la población celular en tres casos clínicos Peripheral giant cell granuloma: immunohistochemical analysis of different markers. Study of three cases

    Directory of Open Access Journals (Sweden)

    Falaschini S

    2007-08-01

    Full Text Available El granuloma periférico de células gigantes (GPCG es una lesión de tejido blando no neoplásica ocasionada por una reacción hiperplásica a consecuencia de un traumatismo o inflamación. Es una lesión reactiva del tejido blando que se desarrolla exclusivamente en la cavidad oral y con una ligera predilección en el sexo femenino. La localización habitual de GPCG es en la región de los premolares y la mucosa de la cresta alveolar edéntula. Se presentan tres casos con GPCG (dos hombres y una mujer con una edad comprendida entre los 25 y 35 años. Todos los pacientes se trataron con resección quirúrgica y ninguno sufrió recidivas. Con el propósito de determinar el posible origen de las células estromales mononucleares y de las células gigantes multinucleares, las muestras de cada caso se estudiaron mediante inmunohistoquímica (marcadores CD-68, CD-34 y α-1 antitripsina con el fin de evaluar la expresión del linaje endotelial y del linaje monocito/macrófago. Los resultados inmunohistoquímicos mostraron una marcada positividad difusa de CD-68 en las células estromales mononucleares y en las células gigantes multinucleadas. Estas últimas resultaron ser inmunonegativas para CD-34 y sólo puntualmente positivas para α-1 antitripsina. Estos resultados sugieren que las cιlulas gigantes multinucleares poseen un fenotipo osteoclαstico, proviniendo del linaje monocito/macrσfago, y que no derivan del linaje de las células endoteliales de los capilares. Se establece la importancia de un exhaustivo diagnóstico y de una exéresis quirúrgica completa de la lesión (curetaje óseo con el propósito de evitar la reabsorción del diente y hueso adyacente.

  13. Consumo e comportamento ingestivo de caprinos e ovinos alimentados com palma gigante (Opuntia ficus-indica Mill) e palma orelha-de-elefante (Opuntia sp.) = Intake and ingestive behavior of sheep and goats fed with cactus pear (Opuntia ficus-indica Mill) and prickly pear (Opuntia sp.)

    OpenAIRE

    Agenor Costa Ribeiro Neto; Valéria Louro Ribeiro; Adriana Guim; Mário de Andrade Lira; Ângela Maria Vieira Batista; Maria Caroline de Almeida Cavalcanti

    2008-01-01

    O presente trabalho teve por objetivo avaliar o consumo e comportamento ingestivo de caprinos e ovinos alimentados com palma Gigante (Opuntia ficus-indica Mill) e palma Orelhade-elefante (Opuntia sp.). Foram utilizados 20 animais mestiços, sendo dez caprinos e dez ovinos, alojados em galpão coletivo, contidos individualmente por meio de cordas, distribuídos em delineamento inteiramente casualizado, em um arranjo fatorial 2 x 2 (duas espécies animais e duas variedades de palma). As observações...

  14. Giant duodenal ulcer perforation: a case of innovative repair with an antrum gastric patch Perforación de ulcus gigante duodenal: reparación innovadora mediante una plastia del antro gástrico

    Directory of Open Access Journals (Sweden)

    Javier A. Cienfuegos

    2012-08-01

    Full Text Available Backgrounds: the treatment of a perforated giant duodenal ulcer (GUDs represents a formidable surgical challenge regarding the duodenal wall defect repair in severe peritonitis setting. A high incidence of dehiscence and hospital mortality (15-40%- has been reported with the majority of the techniques. We report a case of GUDs perforation successfully treated with a subtotal gastrectomy and a gastric patch with the remnant antrum, for repairing the duodenal defect. Case report: a 63-years-old man with antecedents of peptic ulcer disease presents a large duodenal ulcer perforation with 48 hrs delay and associated with severe peritonitis and a retroperitoneal collection. A subtotal gastrectomy with Billroth II reconstruction and reconstruction of the duodenal defect with a patch of the remnant antrum was carried out. The patient was discharged at 17th postoperative day with good tolerance. Discussion: the duodenal defect repair with a patch of the remant antrum, represents a valid alternative in similar circumstances. To our knowledge, it appears to be the first clinical description of this technique.Antecedentes: el tratamiento de un ulcus duodenal gigante (UDG; > 2 cm perforado entraña una gran dificultad técnica, por la reparación del gran defecto duodenal; y por la peritonitis sobreañadida. Todas las técnicas descritas se asocian con un índice elevado de dehiscencias y una mortalidad del 15-40%. Describimos por primera vez el caso de un UDG perforado, tratado mediante una gastrectomía subtotal y con una plastia del antro gástrico remanente. Caso clínico: varón de 63 años que se interviene de un UDG perforado en la 2ª porción duodenal asociado con peritonitis severa y disección de la gotiera parieto-cólica derecha retroperitoneo. Se realiza gastrectomía tipo Bilroth II y reparación del defecto duodenal mediante una plastia con la pared del antro gástrico remanente. El paciente fue dado de alta a los 17 días. Discusión: la

  15. BROCA GIGANTE DA CANA-DE-AÇÚCAR, TELCHIN LICUS LICUS (DRURy, 1773 NA REGIÃO CENTRO-SuL: PREOCUPAÇÃO PARA OS PRODUTORES

    Directory of Open Access Journals (Sweden)

    SILVA JUNIOR, Mauricio Pacheco da

    2008-01-01

    Full Text Available The sugar cane plantation expands its borders each year, throughout the national territory. Thus,increases the amount of biomass that will to be exploited by man in sugar and alcohol produce and also byother organisms, which will have food in abundance. The growth of mechanized harvesting, with the consequentdecrease in burning of straw and the expansion of the sucroalcooleiro sector are causing changes into entomofaunain certain areas or regions of sugar cane plantation. One of the new threats to the sugar cane plantations in southcentralregion, causing uncertainty and concern to farmers, is the giant worm, Telchin licus licus (DRURY, 1773.This worm has always been considered pest in sugar cane plantation in the North and Northeast regions of thecountry, and, just nowadays, it is a matter of concern to the sugarcane from South Centre region. This observationis to alert the sugar cane farmers about the risk of spread of the pest and damage that can be generated by this specie.A cultura da cana-de-açúcar expande suas fronteiras a cada ano, por todo o território nacional. Comisso, aumenta, a quantidade de biomassa que será aproveitada pelo homem, na produção de açúcar e álcool e,também, por outros organismos, que terão alimentos em abundância. O crescimento da colheita mecanizada coma conseqüente diminuição da queima da palha e a expansão do setor sucroalcooleiro estão provocando mudançasda entomofauna de determinadas áreas ou regiões de canavieiras. Uma das novas ameaças às plantações de canade-açúcar na região Centro-Sul, causando incerteza e inquietação aos produtores, é a broca gigante, Telchinlicus licus (DRURY, 1773. Esse inseto sempre foi considerado praga da cultura da cana-de-açúcar nas regiõesNorte e Nordeste do país, sendo, somente agora, motivo de preocupação para os canaviais da região Centro-Sul.Essa constatação serve para alertar os produtores de cana-de-açúcar sobre o risco de dissemina

  16. [Myelopathy secondary to an aneurysmal bone cyst of thoracic spine].

    Science.gov (United States)

    Navas-García, Marta; Penanes, Juan Ramón; Fraga, Javier; Sola, Rafael G

    2016-02-01

    Introduccion. Los quistes oseos aneurismaticos espinales son lesiones osteoliticas benignas muy infrecuentes constituidas por cavidades hematicas limitadas por septos osteoconectivos y celulas gigantes tipo osteoclastos. Clinicamente se manifiestan con dolor local, sintomas neurologicos secundarios a compresion medular, asi como fracturas, deformidades e inestabilidad vertebral. Presentamos un caso de quiste oseo aneurismatico espinal dorsal con sintomatologia neurologica, tratado mediante una reseccion microquirurgica completa, sin secuelas neurologicas asociadas. Caso clinico. Mujer de 47 años, sin antecedentes traumaticos previos, valorada por presentar un cuadro de parestesias de los miembros inferiores de semanas de evolucion. El estudio radiologico de resonancia magnetica dorsal demostro la existencia de una lesion litica de bordes bien delimitados y esclerosis marginal en D4, con afectacion de los elementos posteriores vertebrales y compresion del cordon medular subyacente. La lesion fue extirpada en su totalidad, con desaparicion de la clinica sensitiva tras la intervencion. El diagnostico anatomopatologico definitivo fue quiste oseo aneurismatico espinal. Conclusion. A pesar de su baja incidencia, los quistes oseos aneurismaticos espinales deben considerarse, en el diagnostico diferencial de los tumores oseos espinales, como una posible causa de mielopatia compresiva subaguda o cronica. La reseccion tumoral completa se considera el tratamiento de eleccion, el cual con frecuencia es curativo y asocia un buen pronostico del paciente a largo plazo.

  17. Cerbral gigantism (Sotos' syndrome)

    Energy Technology Data Exchange (ETDEWEB)

    Dijkstra, P.

    1985-08-01

    The metacarpophalangeal pattern (MCPP) profile in 17 out of 22 patients with Sotos' syndrome was studied throughout the growth period, from 2 weeks to 19 years of age. Two typical MCPP profiles will be described. The first type of profile was found in 13 patients. Although the form of the profile is the same throughout the years, the lengthening of the fingers is most pronounced around 2 years of age. Before and after that period there is a flattening of the curve. The metacarpals are relatively longer below the age of 3 years, above 3 years the lengthening of the proximal phalanges is more pronounced in the profile. The second type of profile was found in 4 patients. This curve is almost a mirror image of the first profile. The fingers are not as long as in the first type and the profile is less pronounced. In one of the 17 patients the transition from the first type to the second type could be demonstrated. One patient had a normal profile.

  18. Ultrafast and Gigantic Spin Injection in Semiconductors

    Science.gov (United States)

    Battiato, M.; Held, K.

    2016-05-01

    The injection of spin currents in semiconductors is one of the big challenges of spintronics. Motivated by the ultrafast demagnetization and spin injection into metals, we propose an alternative femtosecond route based on the laser excitation of superdiffusive spin currents in a ferromagnet such as Ni. Our calculations show that even though only a fraction of the current crosses the Ni-Si interface, the laser-induced creation of strong transient electrical fields at a ferromagnet-semiconductor interface allows for the injection of chargeless spin currents with record spin polarizations of 80%. Beyond that they are pulsed on the time scale of 100 fs which opens the door for new experiments and ultrafast spintronics.

  19. Lipossarcoma gigante da vulva: relato de caso

    Directory of Open Access Journals (Sweden)

    Priolli Denise Gonçalves

    2003-01-01

    Full Text Available O lipossarcoma é neoplasia rara, originária das células mesenquimais primitivas e, entre os sarcomas, é o tipo histológico mais freqüente. Acomete principalmente os membros, podendo atingir outras regiões, sendo rara a localização genital. Os autores relatam caso de lipossarcoma vulvar em paciente de 27 anos, que apresentava massa de crescimento progressivo que limitava a deambulação. O exame físico mostrava tumor vulvar volumoso e ulcerado. A doente foi submetida à ressecção local, tendo o exame histopatológico diagnosticado lipossarcoma bem diferenciado com margens livres de comprometimento. Atualmente a enferma encontra-se bem, sem recidiva da doença, 24 meses após a cirurgia.

  20. [Gigantic aneurysm of the popliteal artery].

    Science.gov (United States)

    Fernández-Samos, R; Zorita, A; Vázquez, J G; Morán, C; Vaquero, F

    1990-01-01

    A giant popliteal aneurysm case, whose first symptom was an acute ischemia on the limb, caused by thrombosis, which was successfully treated, is reported. Although popliteal aneurysm is not a rare event, the interest of this case is focused on its extraordinary size and unique location.

  1. Gigant Eesti Gaas razdajot seti / Artur Tooman

    Index Scriptorium Estoniae

    Tooman, Artur, 1971-

    2004-01-01

    Eesti Gaas sõlmis firmadega, mis on aastate jooksul ehitanud kümneid kilomeetreid gaasitrasse, tähtajatud lepingud. Nüüd on viieteistkümnel firmal gaasijagamise litsents. Majandus- ja kommunikatsiooniministeeriumi kavandatavatest muutustest gaasi müümisel ja transportimisel. Kaart

  2. Diversification of Chilean aquaculture: the case of the giant barnacle Austromegabalanus psittacus (Molina, 1782 Diversificación de la acuicultura chilena: el caso del cirripedio gigante Austromegabalanus psittacus (Molina, 1782

    Directory of Open Access Journals (Sweden)

    Daniel A López

    2012-09-01

    Full Text Available Evidence is presented supporting the technical and economic possibilities of giant barnacle Austromegabalanuspsittacus (Molina, 1782 culture, one of the main alternatives for diversifying aquaculture in Chile. Spat collection from the wild varied between different sites in the north and south of the country and according to type of artificial collector. Growth also varied between sites (greater in the north, technological systems (greater in tubular systems and depths (greater at 4 m. Average commercial size in the national market was reached over a period between 18 and 24 months. A long-line can produce between 7 to 10 gross ton during this period, therefore average annual fisheries production can be reached with only 10 to 30 long-lines, in an area of 1 to 3 ha. There is demand for this resource in the external market, particularly in the Japanese market, either as product similar to "fujit subo" (Balanus rostratus, or as a new resource; the relationship between production costs and price determines that giant barnacle culture has commercial potential. Economic indicators for cultured giant barnacle were as follows: net present value (NPV: US$ 490,000; internal rate of return (IRR: 32%; discounted payback period (DPBP: 4 years. Results obtained suggest the natural bank repopulation option, and the development of mass cultures. Giant barnacle culture is based on biological characteristics that differentiate it from other crustaceans species, as well as simple and economic production technologies and favourable economic projections on external markets.Se presentan evidencias de las posibilidades técnicas y económicas del cultivo del cirripedio gigante o "picoroco", Austromegabalanus psittacus (Molina, 1782. Esta especie es una de las principales alternativas para la diversificación de la acuicultura en Chile. La captación de semilla desde el ambiente varió entre distintos sitios del norte y sur del país y según el tipo de colector

  3. BACTERIOLOGICAL QUALITY OF MALASIAN GIANT SHRIMPS (Macrobrachium rosembergii RAISED WITH CHICKEN MANURE QUALIDADE BACTERIOLÓGICA DE CAMARÕES GIGANTES DA MALÁSIA (Macrobrachium rosembergii CULTIVADOS COM DEJETOS DE AVES

    Directory of Open Access Journals (Sweden)

    Albenones José de Mesquita

    2007-09-01

    Full Text Available

    The bacteriological quality of Malaysian giant shrimps (Macrobrachium rosnnbergii raised under captivity condition and fed with aviculture residue was studied in the Station of Pisciculture of the Veterinary School, Federal University of Goiás. The following results were observed: research of Salmonella free in 25g, in all samples; Staphylococcus aureus counts ranged from < 1,0 x 10¹ to 2,0 x 10¹ CFU/g; aerobic or aerobic facultative mesophiles counts ranged from < 1,0 x 10¹ to 1,0³ CFU/g; psicrotrophiles count was < 1,0 x 10¹ to 1,0 x 10³ CFU/g; MPN of total coliforms was 3 to 15/g; MPN of fecal coliforms was 3 to 7/g. All the values above are in agreement to the national pattern.

    KEY-WORDS: Macrobrachium rosembergii; shrimp; chicken manure.

    No presente experimento verificou-se a qualidade bacteriológica de camarões gigantes da Malásia (Macrobrachium rosembergii cultivados em cativeiro, em consórcio com dejetos de avicultura, na Estação de Piscicultura da Escola de Veterinária da Universidade Federal de Goiás, obtendo-se os seguintes resultados: pesquisa de Salmonella ausência em 25g em todas as amostras; contagem de Staphylococcus aureus - variou de < 1,0 x 10¹ a 2,0 x 10¹ UFC/g contagem de microrganismos aeróbios ou facultativos mesófilos viáveis - < 1,0 x 10¹ a 1,0 x l0³ UFC/g ; psicrotróficos - < 1,0 x

  4. Bilateral giant renal angiomyolipoma associated with hepatic lipoma in a patient with tuberous sclerosis Angiomiolipomas renais gigantes bilateralmente associados a lipoma hepático em pacientes com esclerose tuberosa

    Directory of Open Access Journals (Sweden)

    Edison Daniel Schneider-Monteiro

    2003-01-01

    Full Text Available OBJECTIVE: To report a case of bilateral giant renal angiomyolipoma associated with tuberous sclerosis, with successful treatment, and to review the literature concerning angiomyolipoma treatment. CASE REPORT: Patient with tuberous sclerosis and angiomyolipoma diagnosed by ultrasonography during her pregnancy. At that time, the angiomyolipoma on the right side was 9 cm in diameter. Conservative management was selected during her pregnancy. The patient returned 7 years later, with a 24.7 x 19.2 x 10.7 cm tumor on the right side and another of 13 x 11.5 x 6.5 cm on the left side, in addition to multiple small angiomyolipomas. A nephron-sparing surgery with tumoral enucleation was performed on the right side, and after 3 months, the tumor on the left side was removed. Renal function in the post-operative period was preserved, and contrast medium progression was uniform and adequate in both kidneys. CONCLUSION: We conclude that an angiomyolipoma larger than 4 cm should be removed surgically, since they have a greater growth rate and pose a risk of hemorrhage. Resection of smaller tumors is safe and has decreased morbidity. Tumoral enucleation is an effective treatment method that preserves kidney function.OBJETIVO: Relatar um caso de angiomiolipoma gigante, bilateral, associado a esclerose tuberosa, tratado com sucesso e revisar a literatura concernente ao tratamento do angiomiolipoma. RELATO DO CASO: Paciente portadora de esclerose tuberosa, com diagnóstico de angiomiolipoma realizado por ultra-sonografia durante gestação. O tumor apresentava 9cm de diâmetro, à direita. Optou-se por conduta conservadora durante a gestação, e a paciente retornou somente 7 anos após, com tumor de 24,7 x 19,2 x 10,7 cm à direita e outro à esquerda de 13 x 11,5 x 6,5 cm, além de múltiplos angiomiolipomas pequenos. Realizada inicialmente ressecção tumoral à direita, por enucleação, com preservação do parênquima renal, e 3 meses após à esquerda. A

  5. Spontaneous Resolution for a Giant Pancreatic Pseudocyst. A Case Report Resolución espontánea de un pseudoquiste pancreático gigante. A propósito de un caso

    Directory of Open Access Journals (Sweden)

    Jorge Luis Estepa Pérez

    2011-07-01

    cm., dolorosa y de bordes regulares. El ultrasonido abdominal mostró imagen ecolúcida tabicada de aspecto quístico de 104 X 40 mm, posterior a hígado y anterior al páncreas. En tomografía simple y contrastada de abdomen se observó: lesión hipodensa de 10 X 6 cm., líquida (densidad 10 UH en contacto con el lóbulo hepático izquierdo y estómago, crecimiento hacia abajo y llegando hasta zona del mesogastrio, contornos bien delimitados de paredes finas. Se concluyó como pseudoquiste pancreático gigante. La complejidad de la afección y la repercusión en el estado general de la enferma postergó el tratamiento del pseudoquiste, que en su evolución natural se drenó espontáneamente, sin complicaciones ni recidiva de la lesión.

  6. Granuloma periférico de células gigantes: análisis inmunohistoquímico de la población celular en tres casos clínicos Peripheral giant cell granuloma: immunohistochemical analysis of different markers. Study of three cases

    OpenAIRE

    Falaschini S; Ciavarella, D.; Mazzanti, R; M Di Cosola; Turco, M; Escudero, N.; A. Bascones; Lo Muzio, L.

    2007-01-01

    El granuloma periférico de células gigantes (GPCG) es una lesión de tejido blando no neoplásica ocasionada por una reacción hiperplásica a consecuencia de un traumatismo o inflamación. Es una lesión reactiva del tejido blando que se desarrolla exclusivamente en la cavidad oral y con una ligera predilección en el sexo femenino. La localización habitual de GPCG es en la región de los premolares y la mucosa de la cresta alveolar edéntula. Se presentan tres casos con GPCG (dos hombres y una mujer...

  7. Efeito da adubação e do uso de nematicida na composição química da palma forrageira (Opuntia ficus indica Mill Fertilization and nematicide effects on the chemical composition of cactus forage cv. "Gigante"

    Directory of Open Access Journals (Sweden)

    Margareth Maria Teles

    2004-12-01

    Full Text Available O experimento foi realizado em casa de vegetação do Departamento de Zootecnia da UFRPE, com o objetivo de avaliar o efeito da adubação e de nematicida na composição da palma forrageira cv. gigante, com sintoma de amarelecimento. Para o plantio utilizaram-se cladódios de cor amarela de palma (Opuntia ficus indica, Mill. Cv. Gigante provenientes da Estação Experimental de Caruaru - IPA, onde foi observado o amarelecimento das plantas. Os tratamentos constaram da presença e ausência de macronutrientes, micronutrientes e de nematicida, em delineamento experimental de blocos ao acaso, com quatro repetições. Não foram observadas diferenças significativas entre os tratamentos para teores de matéria seca, de K, de Ca e de Mg. Para teores de N, de P e de S, a análise de variância revelou diferença significativa. A média geral para teores de MS, N, P, K, Ca, Mg e S foi de 7,29; 1,19; 0,17; 3,31; 1,84; 0,59 e 0,17%, respectivamente. A adição de micronutrientes e de nematicida não influenciou os resultados obtidos para teores de N, P, K, Ca, Mg e S. Os teores de nitrogênio, fósforo e potássio foram superiores nos cladódios mais jovens da planta. Os nutrientes nitrogênio, fósforo e enxofre foram os únicos que influenciaram a composição química.This experiment was carried out in a greenhouse at the Animal Science Department/UFRPE and aimed to evaluate the fertilization and nematicide effects on the chemical composition of cactus forage cv. "Gigante" suffering chlorotic symptoms. Chlorotic cladodes of Cactus forage cv. "Gigante" were used as planting material and they were collected at the Caruaru Experimental Station/IPA in the same location where those symptoms were previously observed. The treatments tested the presence or absence of macronutrients, micronutrients, and nematicide. A completely randomized block design was used and the treatments were replicated four times. No significant differences were found for dry matter

  8. Association of giant congenital melanocytic nevus, halo nevus and vitiligo in a 75-year-old patient Associação de nevo melanocítico congênito gigante, nevo halo e vitiligo. Relato de caso em paciente de 75 anos

    Directory of Open Access Journals (Sweden)

    Marina Leite da Silveira

    2012-04-01

    Full Text Available A giant congenital melanocytic nevus represents a rare condition. The halo phenomenon may be seen in congenital or acquired melanocytic nevi. In the literature, association of halo nevus and giant congenital melanocytic nevus is rare and the association of both with vitiligo even more rare. A 75-yearold woman at first consultation complained of a hyperchromic bluish-brown hairy macula on the lower back, buttocks and thighs present since birth and an achromic halo of onset three years ago. The histological features were consistent with congenital melanocytic nevus and halo nevus, respectively. After two years the patient developed achromic areas in normal skin, histologically consistent with vitiligo. The authors emphasize the rarity of this triple combination, the patient's age and the absence of malignant degeneration to date.Nevo melanocitico congênito gigante constitui uma condição rara. O fenômeno halo pode ser observado em nevos melanocíticos congênitos ou adquiridos. Na literatura a associação nevo halo e nevo melanocítico congênito gigante é rara e a associação de ambos com vitiligo ainda mais rara. Mulher de 75 anos que à primeira consulta apresentava mácula hipercrômica castanho-azulada pilosa na região lombar, nádegas e coxas desde o nascimento e halo acrômico de aparecimento há 3 anos. Os histológicos foram compatíveis com nevo melanocítico congênito e nevo halo respectivamente. Após dois anos evoluiu com áreas de acromia à distância, com histológico de vitiligo. Os autores ressaltam a raridade desta tripla associação; a idade da paciente e a ausência de degeneração maligna até o presente momento.

  9. Pneumonia complicada por pneumatocele gigante em criança com síndrome da imunodeficência adquirida: importância da fisioterapia respiratória Pneumonia complicated by a giant pneumatocele in a child with acquired immunodeficiency syndrome: importance of chest physiotherapy

    Directory of Open Access Journals (Sweden)

    Silvia Regina M. de Paula

    2010-06-01

    Full Text Available OBJETIVO: Descrever os efeitos do tratamento fisioterapêutico na prevenção de complicações respiratórias de uma criança com síndrome da imunodeficiência adquirida, que apresentava pneumatocele gigante. DESCRIÇÃO DO CASO: Criança com oito anos de idade, do sexo feminino, encaminhada para acompanhamento fisioterapêutico em hospital universitário devido a quadro de hipersecreção pulmonar, histórico de pneumonias e presença de pneumatocele gigante. A conduta fisioterapêutica incluiu técnicas de higiene brônquica ativa, envolvendo fluxo aéreo expiratório, com o intuito de promover a desobstrução pulmonar sem causar risco de complicações à criança. O seguimento foi multiprofissional e direcionado à prevenção de infecções recorrentes e de ruptura da bolha, que tornariam necessária a internação hospitalar. Durante o acompanhamento, o quadro pulmonar manteve-se estável, sem aumento ou ruptura da pneumatocele, radiograficamente visível. COMENTÁRIOS: A atuação da fisioterapia respiratória nos casos de pneumatocele gigante não está definida na literatura. Não há, até o momento, evidências de seus efeitos benéficos, bem como diretrizes a respeito dos métodos mais eficientes e seguros. Ao contrário, muito se discute sobre os riscos e complicações decorrentes dessa intervenção. No presente caso, a assistência fisioterapêutica regular foi importante para garantir a estabilidade do quadro pulmonar da criança, sendo necessários estudos com desenho metodológico apropriado para verificação de eficácia clínica.OBJECTIVE: To describe the effects of chest physiotherapy in preventing respiratory complications in a child with acquired immunodeficiency syndrome and a giant pneumatocele. CASE DESCRIPTION: An eight-year-old female child was sent to the physiotherapy service of a university hospital due to pulmonary hypersecretion, repeated pneumonias and presence of a giant pneumatocele. The physiotherapy

  10. The comparison of abdominal-wall-lift gasless and convention laparoscopy in myomectomy for gigantic hysteromyoma in posterior wall%无气腹悬吊式腹腔镜与传统气腹腹腔镜对后壁巨大子宫肌瘤剜除术的临床疗效比较

    Institute of Scientific and Technical Information of China (English)

    吴继蓉; 彭晓梅; 陈霞

    2012-01-01

    目的 探讨无气腹悬吊式腹腔镜在困难子宫肌瘤剜除术中的应用价值.方法 对比分析2009年1月~2011年12月在妇产科同期施行无气腹腹腔镜与气腹腹腔镜后壁巨大子宫肌瘤剜除情况,比较两者手术时间、术中出血量、术后排气时间、住院日、住院费用等情况.结果 两组患者术中无并发症发生,无气腹组手术时间(67.6±24.7)min,术中出血量(80.0±50.1)ml,术后排气时间(1.1±0.5)d,平均住院日(7.2±1.8)d,平均住院费用(6274.5±500.4)元;气腹组手术时间(108.1±25.3)min,术中出血量(184.9±56.3)ml,术后排气时间(2.6±0.4)d,住院日(10.2±2.9)d,住院费用(7510.8±624.7)元.组间比较,差异有显著性(均P<0.05).结论 无气腹悬吊式腹腔镜后壁巨大子宫肌瘤剜除术优于传统气腹腹腔镜,可能会成为子宫肌瘤剜除术的标准术式.%Objective To discuss the value of abdominal lift gasless laparoscopy in g myomectomy for gigantic hysteromyoma in posterior wall. Methods Operation time, blood loss, anus exhaust time, the hospital day,and the cost of hospitalization were compared between 30 cases with gigantic hysteromyoma in the uterus back wall undergone laparoscopy without pneumoperitoneum and 30 cases undergone conventional laparoscopy. Results The general conditions (number and size of myoma) of 2 groups were not significantly different. There were no complications in both group. The average operating time (67. 6±24. 7)min, the amount of bleeding (80. 0±50.1)ml, anus exhaust timed. l±0. 5)d, the hospital day(7. 2±1. 8)d,and the cost of hospitalization(6274. 5±500. 4)RMB of Abdominal-wall-lift gasless laparoscopy group were significantly shorter and cheaper than those of convential laparoscopy group (108. 1±25. 3)min, (184. 9± 56.3)ml, (2.6±0.4)d, (10. 2±2. 9)d, (7510. 8±624. 7)RMB (P<0. 05). Conclusion Gasless laparoscopy exhibits more advantages than conventional laparoscopy in myomectomy for gigantic hysteromyoma

  11. 子宫动脉栓塞联合宫腔镜治疗巨大子宫黏膜下肌瘤临床分析%Uterine artery embolization combined with hysteroscopy in treatment of gigantic submucosal fibroids of uterus

    Institute of Scientific and Technical Information of China (English)

    都君君

    2015-01-01

    目的 探讨对巨大子宫黏膜下肌瘤行子宫动脉栓塞联合宫腔镜治疗的临床效果.方法 随机选取本院2013年8月至2014年3月期间收治的巨大子宫黏膜下肌瘤患者64例,按照治疗方案的不同将其分为观察组和对照组.其中对照组患者行宫腔镜电切术,观察组患者则采用子宫动脉栓塞联合宫腔镜进行治疗,对两组患者的临床治疗效果及其并发症的发生情况进行观察对比.结果 观察组患者的手术治疗总有效率为96.88%,明显高于对照组患者(40.63%);观察组患者术后并发症的发生率为12.50%,明显低于对照组患者(40.63%);差异具有统计学意义(P<0.05).结论 采用子宫动脉栓塞联合宫腔镜治疗巨大子宫黏膜下肌瘤,效果显著,有助于彻底清除肌瘤组织,促进患者术后恢复,建议在临床上进一步推广.%Objective To investigate the clinical effect of uterine artery embolization combined with hysteroscopy in the treatment of gigantic submucosal fibroids of uterus.Methods 64 patients with gigantic submucosal fibroids of uterus admitted in our hospital from August 2013 to March 2014 were randomly selected and were divided into an observation group and a control group according to different treatment regimens.The control group was treated with hysteroscopic surgery and the observation group with uterine artery embolization and hysteroscopy.The clinical therapeutic effect and the incidence of relevant complication in both groups were observed and compared.Results The total effective rate of the surgical treatment of the observation group was 96.88%, which was significantly higher than that of the control group (40.63%);the incidence of postoperative complications of the observation group was 12.50%, which was significantly lower than that of the control group (40.63%);the differences were statistically significant (P<0.05).Conclusions Uterine artery embolization combined with hysteroscopy in the

  12. Gigantic neurocysticercosis: diagnosis and therapy;Neurocisticercose gigante: diagnostico e tratamento

    Energy Technology Data Exchange (ETDEWEB)

    Brandao, Rafael Augusto Castro Santiago; Dellaretti Filho, Marcos Antonio, E-mail: rafabrand@hotmail.co [Hospital Santa Casa de Belo Horizonte, MG (Brazil); Nunes, Tadeu Wilker; Totola, Paolo Victor Fernandes; Fonseca, Vinicius Silveira; Souza, Warley Cristiano de [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Faculdade de Medicina

    2010-07-01

    Neurocysticercosis (NCC) is the most common parasitic infection of the nervous system. Considered a global epidemic, the parasite presents, mainly, as asymptomatic. Usually treatment is clinical, but in some selected cases surgical intervention is a good treatment option. In our case, keeping in view the magnitude of intracranial injury, surgery was the therapy chosen. A female patient, aged 54, Mulatto, native of Novo Cruzeiro (MG) and raised in Belo Horizonte. Presented with intense frontal headache, which progressed to right hemiparesis and seizure. Ten days after onset of symptoms, sought the service of emergency care. Tomography (CT) revealed a hypodense area in left frontoparietal region with characteristics of cystic lesion.

  13. A distância e o conteúdo estelar da região HII gigante G333.1-0.4 - vínculos para a taxa de formação estelar da galáxia

    Science.gov (United States)

    Figuerêdo, E.; Damineli, A.; Blum, R.; Conti, P.

    2003-08-01

    Neste trabalho apresentamos imagens de alta resolução angular da região HII gigante G333.1-0.4 obtidas através dos filtros J, H e K no telescópio de 4-m do CTIO. Este trabalho faz parte de um estudo de regiões HII gigantes no infravermelho próximo que tem por objetivo estudar a natureza da formação de estrelas massivas e traçar a estrutura espiral de nossa galáxia. Nossa determinação da distância é baseada no método da paralaxe espectroscópica de estrelas OB localizadas na seqüência principal de idade zero (ZAMS) do Diagrama HR. No caso de G333.1-0.4, a magnitude aparente das estrelas localizadas na ZAMS indica que a distância não pode ser maior do que o limite inferior determinado por técnica rádio (2,8 kpc). Resultados semelhantes foram encontrados para regiões estudadas anteriormente, reforçando a idéia de que a taxa de formação estelar na Via Láctea é menor do que o determinado a partir de dados rádio. Nossos resultados mais recentes sobre o conteúdo estelar de G333.1-0.4 revelaram vários objetos que possuem cores bastante avermelhadas (H-K > 2,0). Nós identificamos estes objetos usando os diagramas cor-cor e cor-magnitude dos aglomerados. Estes objetos apresentam um forte excesso em emissão na banda K e possivelmente se tratam de estrelas do tipo OB envolvidas por um disco/envelope circumestelar espesso. O estudo da função de massa inical desta região, em conjunto com resultados de nossos trabalhos anteriores, aponta para uma IMF independente da posição galática. A contagem de estrelas nos fornece um valor para o número de fótons no contínuo de Lyman que corrobora com a afirmação de que G333.1-0.4 se encontra mais próxima da menor distância determinada por rádio.

  14. Consumo e comportamento ingestivo de caprinos e ovinos alimentados com palma gigante (Opuntia ficus-indica Mill e palma orelha-de-elefante (Opuntia sp. = Intake and ingestive behavior of sheep and goats fed with cactus pear (Opuntia ficus-indica Mill and prickly pear (Opuntia sp.

    Directory of Open Access Journals (Sweden)

    Agenor Costa Ribeiro Neto

    2008-04-01

    Full Text Available O presente trabalho teve por objetivo avaliar o consumo e comportamento ingestivo de caprinos e ovinos alimentados com palma Gigante (Opuntia ficus-indica Mill e palma Orelhade-elefante (Opuntia sp.. Foram utilizados 20 animais mestiços, sendo dez caprinos e dez ovinos, alojados em galpão coletivo, contidos individualmente por meio de cordas, distribuídos em delineamento inteiramente casualizado, em um arranjo fatorial 2 x 2 (duas espécies animais e duas variedades de palma. As observações comportamentais foram realizadas em intervalos de 5 min. por um período de 24h. Os consumos de matéria seca, extrato etéreo, fibra em detergenteácido, carboidratos totais e carboidratos não-fibrosos foram menores (p 0,05 sobre o tempo gasto comalimentação e eficiência de alimentação. O tempo gasto com ruminação foi maior para a dieta com palma Gigante, consequentemente os animais da dieta com palma Orelha-de-elefante permaneceram mais tempo em ócio. Comparando as espécies caprina e ovina, verificou-se que aeficiência de ruminação, tanto de MS quanto de FDN, foi maior para a espécie ovina. Os animais gastaram mais tempo ruminando deitados do que em pé, mas não foi verificada diferença quanto ao lado escolhido para deitarem.The objective of this study was to evaluate the intake and ingestive behavior of sheep and goats fed with cactus pear (Opuntia ficus-indica Mill and prickly pear (Opuntia sp.. Twenty crossbred animals – 10 sheep and 10 goats – were used. They were lodged in a collective shed, contained individually with ropes, distributed using a completely randomized design, and treated with a 2 x 2 factorial arrangement (2 animal species and 2 varieties of cactus. Behavioralobservations were made at five-minute intervals during a 24-hour period. Dry matter, ether extract, acid detergent fiber, total carbohydrate and non-fibrous carbohydrate intake were reduced (p 0.05 on feeding time and feeding efficiency. The time spent with

  15. Raeder's syndrome after embolization of a giant intracavernous carotid artery aneurysm: pathophysiological considerations Síndrome de Raeder após embolização de aneurisma gigante de artéria carótida intracavernosa: considerações fisiopatológicas

    Directory of Open Access Journals (Sweden)

    Claudio Esteves Tatsui

    2005-09-01

    Full Text Available We present the case of a 47 years old woman submitted to an endovascular trapping of a left cavernous internal carotid artery aneurysm, in which the distal balloon was inflated, as usually done, within the cavernous segment of the internal carotid artery, different from the proximal one which was inflated inside the carotid canal due to technical problems. Consequently, a clinical picture of Raeder's paratrigeminal neuralgia took place. This is the first case report in the literature with theses characteristics. A review of the anatomic pathways and further considerations about the possible pathophysiological mechanisms involved are presented.Apresentamos o caso de uma mulher de 47 anos submetida a obliteração endovascular de um aneurisma gigante de carótida interna cavernosa à esquerda, no qual o balão distal foi inflado, tal como usual, dentro do segmento cavernoso da artéria carótida interna, diferente do proximal, o qual foi inflado dentro do canal carotídeo devido a problemas técnicos. Conseqüentemente, um quadro clínico de neuralgia paratrigeminal de Raeder se instalou. Este é o primeiro relato na literatura com estas características. Uma revisão das vias anatômicas e maiores considerações a respeito de possíveis mecanismos fisiopatológicos envolvidos são apresentados.

  16. Anastomose entre a artéria carótida externa e a artéria carótida interna supraclinóidea utilizando enxerto de veia safena para tratamento de aneurisma gigante do segmento cavernoso da carótida interna: relato de caso

    Directory of Open Access Journals (Sweden)

    Azevedo Filho Hildo

    2001-01-01

    Full Text Available Procedimentos cirúrgicos alternativos para o tratamento de aneurismas "não clipáveis" da carótida intracavernosa incluem ligadura do vaso ou exclusão do segmento que origina a lesão. Essas técnicas estão associadas a riscos de complicações isquêmicas, mesmo em pacientes com sistema de colaterais funcionante. Portanto, um tratamento adequado requer revascularização encefálica para manter o fluxo sanguíneo nos territórios envolvidos. Relatamos o caso de uma paciente de 47 anos com sintomas e sinais isquêmicos embólicos e paralisia do III nervo craniano causados por aneurisma gigante, parcialmente trombosado, do segmento cavernoso da carótida interna. A paciente foi submetida a ponte anastomótica entre a carótida externa cervical e a carótida interna supraclinoidea utilizando enxerto de veia safena, seguido de exclusão do segmento vascular contendo o aneurisma, com bom resultado e sem complicações.

  17. Perfluoroctano líquido como tamponante vitreorretiniano de curta duração no pós-operatório de portadores de descolamento de retina por ruptura gigante Perfluoroctane liquid as a short-term vitreous-retinal tamponade in the postoperative period in patients with retinal detachment due to giant tears

    Directory of Open Access Journals (Sweden)

    Marcelo Carvalho Ventura

    2007-06-01

    Full Text Available OBJETIVOS: Relatar os resultados de vitrectomia via pars plana com utilização de perfluocarbono líquido (Perfluoroctano-Ophtalmos®, como tamponante vítreo-retiniano de curta duração, no pós-operatório de portadores de descolamento de retina, por ruptura gigante. MÉTODOS: Estudaram-se dez desses pacientes. Todos os casos eram complicados por vitreorretinopatia proliferativa grau B ou pior com rupturas que variavam em extensão de 90º a 210º. O perfluorocarbono líquido foi introduzido, por via pars plana, com o volume necessário para ultrapassar o limite posterior da ruptura, permanecendo no pós-operatório por cinco dias, estando os pacientes em decúbito dorsal. Após esse período submetiam-se a segunda intervenção para troca do perfluorocarbono líquido para gás ou óleo de silicone. RESULTADOS: Após período de acompanhamento médio de 16,2 ± 12,4 meses (2 a 43 meses, 80% das retinas estavam aplicadas, sendo necessária a repetição desta técnica em 1 caso (10% caso e em 2 casos (20% não houve reaplicação da retina por vitreorretinopatia avançada. Houve melhora da acuidade visual em 5 casos (50%. CONCLUSÃO: Observaram-se bons resultados quanto à aplicação da retina (80% e melhora da acuidade visual (50% quando do uso do perfluorocarbono líquido como tamponante vitreorretiniano de curta duração no pós-operatório de cirurgias de descolamento de retina por rupturas gigantes.PURPOSE: To report pars plana vitrectomy results of intravitreous use of liquid perfluorocarbon as a short-term postoperative tamponade in retinal detachment due to giant tears in a series of patients. METHODS: Ten of those patients, all of them complicated by proliferative vitreoretinopathy grade B or worse, with tear extension varying from 90º to 210º were studied. Perfluorocarbon liquid was injected via pars plana until the posterior tear limit, remaining in the postoperative period during five days, with the patients in supine position

  18. Astrocitoma subependimário de células gigantes em pacientes com esclerose tuberosa: achados em ressonância magnética de dez casos Subependymal giant cell astrocytoma in patients with tuberous sclerosis: magnetic resonance imaging findings in ten cases

    Directory of Open Access Journals (Sweden)

    Karina Takata

    2007-06-01

    Full Text Available OBJETIVO: Relatar os achados de ressonância magnética (RM em 10 casos de astrocitoma subependimário de células gigantes (ASCG em pacientes com esclerose tuberosa (ET. MÉTODO: Foram estudados de forma retrospectiva 10 pacientes com ET e diagnóstico histológico comprovado de ASCG. Quatro pacientes eram do sexo masculino e seis do feminino, com idade média de 15,7 anos. Todos os pacientes foram investigados com RM, sendo os exames revisados por dois radiologistas, havendo decisão por consenso sobre os achados de imagem. Foram analisados os seguintes achados: localização, dimensões, intensidade de sinal em T1/T2, realce pós-contraste e outros achados associados. RESULTADOS: Todos os pacientes apresentaram lesão única sugestiva de ASCG, medindo entre 1,5 cm e 8 cm em seu maior diâmetro. Oito lesões foram encontradas junto ao forame de Monro (80% e duas adjacentes ao corpo do ventrículo lateral (20%. Os tumores apresentavam nas imagens pesadas em T1 médio sinal (70% e em T2 alto sinal (100%, com realce intenso após a administração do gadolínio (100%. CONCLUSÃO: Os astrocitomas subependimários de células gigantes em pacientes com ET em geral apresentam-se como lesão única próxima ao forame de Monro, com médio sinal nas imagens ponderadas em T1, alto sinal em T2 e realce intenso após a administração de contraste.OBJECTIVE: To report the magnetic resonance imaging (MRI findings in 10 patients with subependimal giant cell astrocytoma (SGCA and tuberous sclerosis (TS. METHOD: Ten patients were retrospectively studied, presenting TS and histologically proven SGCA. Four patients were male and six female, with mean age 15.7 years. All patients underwent MRI, which was analyzed by two radiologists, final diagnosis was reached by consensus. The following findings were studied: topography, size, signal intensity on T1/T2-weighted images, contrast enhancement and associated findings. RESULTS: All patients presented a single lesion

  19. Avaliação da agressividade da lesão de células gigantes periférica da cavidade bucal através de estudo histoquímico-imunohistoquímico = Evaluation of the aggressiveness of peripheral giant cell lesion of the oral cavity by means of a hystochemical-immunohystochemical study

    Directory of Open Access Journals (Sweden)

    De Carli, João Paulo

    2008-01-01

    Full Text Available Objetivo: Estudar a agressividade da lesão de células gigantes periférica (LCGP através de um estudo histoquímico e imunohistoquímico. Metodologia: Foram revisados os arquivos da Faculdade de Odontologia de Araçatuba (FOA-UNESP e da Faculdade de Odontologia da Universidade de Passo Fundo (FOUPF, tendo sido obtidos 181 casos de LCGP, dos quais 61 preencheram os critérios de elegibilidade. Primeiramente, graduou-se a agressividade das LCGPs, que foram distribuídas em três grupos de estudo com base em achados clínicos e radiográficos. Em seguida, os cortes histológicos das 61 LCGPs, corados por H. E. , foram analisados para confirmação diagnóstica. Posteriormente, investigou-se a proliferação celular de 15 casos de LCGPs através de contagem e aferição da área de AgNORs (regiões de organização nucleolar e avaliação da imunoexpressão dos marcadores PCNA, Ki-67 e p53. Resultados: Não se constatou diferença na área das AgNORs e na expressão do PCNA entre as LCGPs dos três grupos estudados, e o p53 não foi efetivo na imunomarcação das lesões analisadas. Notou-se diferença estatisticamente significativa no número de AgNORs e na expressão do Ki-67 entre os grupos estudados. Conclusão: Os resultados de AgNOR e Ki-67 sugerem que a agressividade clínicoradiográfica das LCGPs pode ser relacionada com sua atividade proliferativa celular

  20. Aneurisma gigante do segmento intracavernoso da carótida interna associado a doença renal policística autossômica dominante: relato de caso Giant aneurysm of the intracavernous internal carotid artery associated with autosomal dominant polycystic kidney disease: case report

    Directory of Open Access Journals (Sweden)

    Keven F. Ponte

    2006-09-01

    Full Text Available Apresenta-se o caso de mulher de 60 anos com doença renal policística autossômica dominante (DRPAD que desenvolveu quadro de cefaléia e oftalmoplegia completa à direita. A TC levantou a hipótese de um aneurisma gigante do segmento intracavernoso da carótida interna direita, o que foi confirmado pela arteriografia. Realizou-se, então, tratamento endovascular por oclusão do vaso parental com molas destacáveis no segmento supraclinóideo. A paciente evoluiu com a interrupção da cefaléia e com redução parcial da ptose e da oftalmoplegia. Neste artigo, enfatiza-se a relação entre DRPAD e aneurismas intracranianos. Comenta-se a história natural dos aneurismas originados no segmento intracavernoso da artéria carótida interna e comparam-se as opções terapêuticas no manejo destas lesões.We report the case of a 60 years-old woman with autosomal dominant polycystic kidney disease (ADPKD that presented with headache and right complete ophthalmoplegia. The CT scan raised the possibility of a giant aneurysm of the right intracavernous internal carotid artery, confirmed by angiography. The patient underwent endovascular occlusion of parent vessel with detachable coils, then she presented interruption of headache and partial recovery of ptosis and ophthalmoplegia. We emphasize the relationship between ADPKD and intracranial aneurysms. We also discuss the natural history and compare the therapeutic options for the management of giant aneurysms of the cavernous portion of the carotid artery.

  1. 血清叶酸和维生素B12检测在巨幼细胞性贫血诊疗中的作用%Detection of Serum Folate and Vitamin B1 2 in the Role of Gigantic Young Cell Anemia Diagnosis and Treatment

    Institute of Scientific and Technical Information of China (English)

    任从棉; 常娟玲; 李志军

    2014-01-01

    Objective To explore the serum folic acid (FOL)and vitamin B12 (Vit B12)levels in gigantic young cell anemia (MA)in the diagnosis and treatment effect.Methods Select in March 2010 to March 2013,examined with clear cell mor-phology in the diagnosis of 50 patients with gigantic young cell anemia as observation group.Another selection during the same period to hospital for a medical 52 cases of healthy people as control group,observation group treated with FOL and Vit B1 2 8~1 5 d,with SIEMENS SIEMENS ADVIA Centaur CP automatic chemiluminescence immune analyzer to observe group before and after treatment and the control group was used to detect the serum FOL and Vit B1 2 levels,respectively, for all the test results were analyzed.Results Observation group before treatment serum FOL and Vit B12 levels (2.23± 0.11 ng/ml and 125.21±94.14 pg/ml)significantly lower than the control group (5.49± 3.91 ng/ml and 356.70±185.46 pg/ml),differences were statistically significant (t=5.89,P0.05;t=1.51,P>0.05).Conclusion The detection of serum FOL and Vit B12 levels,can be used as a gigantic young cell anemia is the effective means to the diagnosis and treatment effect monitoring.%目的:探讨血清叶酸(FOL)和维生素 B12(Vit B12)水平在巨幼细胞性贫血(MA)诊疗中的作用。方法选取2010年3月~2013年3月,经检查有明确细胞形态学诊断的巨幼细胞性贫血患者50例作为观察组;另选取同期来院进行体检的52例健康人群作为对照组,观察组接受FOL和Vit B12治疗8~15天,用西门子SIEMENS ADVIA Centaur CP全自动化学发光免疫分析仪对观察组治疗前、治疗后及对照组分别进行血清 FOL和 Vit B12水平检测,对所有检测结果进行统计分析。结果观察组治疗前血清 FOL和 Vit B12水平(2.23±0.11 ng/ml和125.21±94.14 pg/ml)明显低于对照组(5.49±3.91 ng/ml和356.77±185.46 pg/ml),差异均有统计学显著性意义(t=5.89,P<0.01;t=7

  2. Diagnóstico prenatal de quiste de Cavum Velum Interpositum

    Directory of Open Access Journals (Sweden)

    Yolimar Navarro Briceño

    2016-12-01

    Full Text Available Anterior midline intracranial cysts may be found in three forms: cavum septum pellucidum, cavum vergae, and cavum velum interpositum. The cavum velum interpositum cyst represents a cerebrospinal fluid filled space formed by the corpus callosum and fornix above, the roof of the third ventricle and thalamus below and of the fornix on each side laterally. We report the case of a 28-year-old pregnant woman who attended to prenatal consult at 30 weeks. During ultrasound evaluation it was found a 25 milimeters of diameter, intracranial, interhemispheric and, anechoic cystic lesion inferior of corpus callosum, accompanied by a slight enlarged third ventricle without evidence of compressive hydrocephalus. Karyotype was normal. Diagnosis of cavum velum interpositum cyst was considered. A normal newborn was obtained after spontaneous vaginal birth. Magnetic resonance after birth confirmed diagnosis

  3. Pineal cyst: study with magnetic resonance. Quistes pineales simples: estudio con resonancia magnetica

    Energy Technology Data Exchange (ETDEWEB)

    Paniagua, J.C.; Aleixandre, A.; Esteban, M.J.; Marti-Bomati, L.; Poyatos, C. (Hospital Universitario La Fe, Valencia (Spain))

    1992-01-01

    The use of magnetic resonance (MR) as a diagnostic technique in central nervous system pathology has made possible the detection of structures that are hard to view with other diagnostic methods. In 21 patients in whom the existence of pineal cyst was detected by chance, we describe the study technique employed and present the MR characterization. In the absence of specific clinical symptoms and sings, the differential diagnosis of this pathology, with respect to other neoplastic formations located in the pineal gland, is based on its typical location behind the third ventricle, its size, which does not vary in the different serial studies, and its signal intensity. (author)

  4. Mesenteric and Omental Primary Cysts: Image Findings; Quistes primarios mesentericos y omentales: hallazgos e imagen

    Energy Technology Data Exchange (ETDEWEB)

    Castillo Caro, S.; Vargas Serrano, B. [Hospital Universitario Virgen del Rocio. Sevilla (Spain); Rodriguez, M. L. [Hospital Morales Meseguer. Murcia (Spain)

    2004-07-01

    To describe the radiological appearance of different histological subtypes of mesenteric and omental cysts: lymph angioma, enteric duplication cysts, enteric and mesothelial, and non-pancreatic pseudocysts. The basis of this study is the clinical, radiological and pathological review os 13 cases from our departmental archives involving cystic lesions of the omentum or mesentery: 3 lympangiomas, one enteric duplication cyst, 7 mesothelial cysts and 2 non-pancreatic pseudocysts. The sex distribution was 9 women and 4 men. Most common clinical findings were pain and abdominal distension. Echography (ultra-sound scanning) was performed in 8 cases, abdominal x-ray in 10 and computerized tomography (CT in 13 cases. In the ultra-sound and CT studies, lymphangiomas appeared as large thin-walled multilocular cystic lesions. Mesonthelial cysts were observed as unilocular thin-walled (calcified in 2 cases) cystic lesions of varying size. Duplication cysts were unilocular, seemingly liquid-filled under ultrasound scan and with a thick calcified wall. the non-pancreatic pseudocysts were of varying size, heterogeneous and thick-walled. Aside from being able to determine whether abdominal masses are cystic in nature, ultrasound scan and CT can determine whether such are mesenteric or omental in origin. They can also determine the cystic nature of an abdominal mass which would be helpful in narrowing down diagnostic possibilities. It is important to remember that some malignant neoplasia can occasionally resemble cystic lesions with imaging techniques. (Author) 7 refs.

  5. NEUROCISTICERCOSIS PARENQUIMATOSA EN FORMA DE QUISTES DEGENERATIVOS. CASO CLÍNICO.

    Directory of Open Access Journals (Sweden)

    Iraola Ferrer MD

    2012-01-01

    Full Text Available Neurocysticercosis is the most frequent parasitism in the central nervous system. It consists on the localization of the larval form of the Taenia solium in the neuraxis or in the meningeal- ventricular compartment of the central nervous system. At present it represents a serious health problem. Several anatomoclinical syndromes of neurocysticercosis have been described. A case of mild parenchymal neurocysticercosis in degenerating cyst form where cephalalgia was the predominant symptom resulted into several evaluations without any definite diagnosis. After a year, a simple and contrastive skull CT scan was performed on the patient. Suggested lesions of parenchymal neurocysticercosis appeared. A treatment with praziquantel and prednisone was given to the patient without any clinical and tomographic improvement on the patient. This brought about the admission of the patient into the hospital. A treatment with dexamethasone and albendazole began. As a result of this treatment, the patient began to improve her clinical and tomographic condition. During the patient's follow up, she continued asymptomatic.

  6. MASA NASAL CONGÉNITA: QUISTE EPIDERMOIDE Congenital nasal mass: epidermoid and dermoid cyst

    Directory of Open Access Journals (Sweden)

    Gilberto Eduardo Marrugo-Pardo

    2010-12-01

    Full Text Available Las masas nasales congénitas de la línea media son poco frecuentes, pero ante la sospecha clínica debe realizarse una valoración completa que incluya imágenes diagnósticas para descartar origen intracraneal. Se presenta un caso clínico con la presencia de dos entidades clínicas de diferentes características histológicas junto con una revisión de la literaturaCongenital midline nasal mass are infrequent but before the clinical suspicion should be carried out a complete evaluation that includes diagnostic images with the aim of ruled out intracraneal lesion. This paper presented a clinical case is with two clinical entities of different histological characteristic together with a revision of the literature.

  7. Paraurethral cyst. A case report Quiste parauretral. Presentación de un caso

    OpenAIRE

    2011-01-01

    The paraurethral or Skene’s duct cyst, is a rare diagnostic entity in a newborn. It represents less than 0,5 % of congenital malformations of the urinary tract. All over the world it is reported an incidence of 1:2000 to 1:7000 in female births. In the newborn, the paraurethral cyst is caused by retention of secretions in the Skene's gland due to the obstruction of its ducts. Most of these cysts decrease in size during the first four to eight weeks, but they may cause symptoms of infection or...

  8. Composição físico-química e potencial para ensilagem do sorgo-de-guiné gigante em seis épocas de semeadura Physical-chemical composition and ensiling potential of Giant Guinea sorghum in six different sowing dates

    Directory of Open Access Journals (Sweden)

    Gustavo Pavan Mateus

    2005-09-01

    Full Text Available A ausência de culturas alternativas para o cultivo de outono-inverno é um entrave nos sistemas de produção agrícola, principalmente em regiões de inverno seco. O objetivo deste trabalho foi avaliar a produção de forragem, o potencial para ensilagem e a composição química do sorgo-de-guiné gigante (Sorghum bicolor subsp. bicolor raça guinea, de acordo com a época de semeadura. O delineamento experimental utilizado foi o de blocos casualizados, com quatro repetições e seis épocas de semeadura. Verificou-se antecipação dos estádios de desenvolvimento da planta, à medida que houve atraso na semeadura, em virtude de a espécie apresentar sensibilidade ao fotoperíodo. Semeaduras tardias, apesar de menor produtividade, proporcionaram forragem com características químico-bromatológicas melhores. Diante da boa produção de matéria seca e seu potencial para ensilagem, esse genótipo é uma boa opção a ser utilizada.The lack of alternative crops for fall-winter cultivation is a drawback in the utilization of agricultural production systems, especialy in regions with dry winters. The purpose of this study was to evaluate the potential of Giant Guinea sorghum (Sorghum bicolor subsp. bicolor guinea race for forage production, ensiling and plant chemical composition, in different sowing dates. The experimental design was a randomized block, with four replications, and six sowing dates. Although sowing was late, Giant Guinea sorghum showed anticipation in development stages due to sensibility to photoperiod; its dry matter production was low, nevertheless the species presented a better quality of forage mass. Due to the considerable capacity of dry matter production and ensiling potential, this species is a good option.

  9. Acromegalic gigantism, physicians and body snatching. Past or present?

    Science.gov (United States)

    de Herder, Wouter W

    2012-09-01

    The skeletons of 2 famous acromegalic giants: Charles Byrne (1761-1783) and Henri Cot = Joseph Dusorc (1883-1912) and the embalmed body of the famous acromegalic giant Édouard Beaupré (1881-1904) all ended up in the medical collections of museums despite the fact that these patients had never donated or even refused to donate their corpses, nor had their relatives given permission. The corpse of the acromegalic giant John Aasen (1890-1938) was voluntarily donated to a physician annex collector of trivia from acromegalic giants. The autopsy on the acromegalic giant John Turner (1874-1911) was performed during his funeral ceremony without the relatives being informed. Only recently, the acromegalic giant Alexander Sizonenko (1959-2012) was made a financial offer during his life in exchange for his body after his death. The case-histories of these 6 patients and also the circumstances that led to the (in-) voluntary donation of their bodies are reviewed.

  10. Nurka surutud gigant näitab hambaid / Edith Steinberg

    Index Scriptorium Estoniae

    Steinberg, Edith

    2005-01-01

    Maailma suurim autotootja General Motors teatas aasta lõpus, et vabastab töölt 30 000 inimest ja tosin Põhja-Ameerika tehast hakkavad tööle osalise koormusega. Hoolimata asjaolust, et korporatsioonil on ligi 75 miljardi dollariline võlg, püüab GM-i tegevjuht Rick Wagoner avalikkust rahustada väitega, et hetkel on ettevõttel raha 22 miljardit ja pankrotti välja kuuluta pole plaanis. Vt. samas: Autsaiderite võidukäik; Koledada autod ja valed otsused

  11. Gigantic Enhancement in Sensitivity Using Schottky Contacted Nanowire Nanosensor

    KAUST Repository

    Wei, Te-Yu

    2009-12-09

    A new single nanowire based nanosensor is demonstrated for illustrating its ultrahigh sensitivity for gas sensing. The device is composed of a single ZnO nanowire mounted on Pt electrodes with one end in Ohmic contact and the other end in Schottky contact. The Schottky contact functions as a "gate" that controls the current flowing through the entire system. By tuning the Schottky barrier height through the responsive variation of the surface chemisorbed gases and the amplification role played by the nanowire to Schottky barrier effect, an ultrahigh sensitivity of 32 000% was achieved using the Schottky contacted device operated in reverse bias mode at 275 °C for detection of 400 ppm CO, which is 4 orders of magnitude higher than that obtained using an Ohmic contact device under the same conditions. In addition, the response time and reset time have been shortened by a factor of 7. The methodology and principle illustrated in the paper present a new sensing mechanism that can be readily and extensively applied to other gas sensing systems. © 2009 American Chemical Society.

  12. Gigantic particle collision machine does "mini Big Bangs"

    CERN Multimedia

    2007-01-01

    "The world's largest machine is reputed to be the Large Hadron Collider (LHC) at CERN in Geneva and everything about it is big. Designed to carry out high energy particle collisions, when completed next year, one of the collider's experiments includes a 10'000 ton detector." (1/2 page)

  13. Acromegalic gigantism, physicians and body snatching. Past or present?

    NARCIS (Netherlands)

    W.W. de Herder (Wouter)

    2012-01-01

    textabstractThe skeletons of 2 famous acromegalic giants: Charles Byrne (1761-1783) and Henri Cot = Joseph Dusorc (1883-1912) and the embalmed body of the famous acromegalic giant Édouard Beaupré (1881-1904) all ended up in the medical collections of museums despite the fact that these patients had

  14. Familial gigantism caused by an NSD1 mutation.

    NARCIS (Netherlands)

    Haelst, M.M. van; Hoogeboom, J.J.; Baujat, G.; Bruggenwirth, H.T.; Laar, I. van de; Coleman, K.; Rahman, N.; Niermeijer, M.F.; Drop, S.L.; Scambler, P.J.

    2005-01-01

    A three-generation family with autosomal dominant segregation of a novel NSD1 mutation (6605G --> A, resulting in Cys2202Tyr) is reported. Haploinsufficiency of NSD1 has been identified as the major cause of Sotos syndrome. The overgrowth condition (MIM 117550) is characterized by facial anomalie

  15. Nurka surutud gigant näitab hambaid / Edith Steinberg

    Index Scriptorium Estoniae

    Steinberg, Edith

    2005-01-01

    Maailma suurim autotootja General Motors teatas aasta lõpus, et vabastab töölt 30 000 inimest ja tosin Põhja-Ameerika tehast hakkavad tööle osalise koormusega. Hoolimata asjaolust, et korporatsioonil on ligi 75 miljardi dollariline võlg, püüab GM-i tegevjuht Rick Wagoner avalikkust rahustada väitega, et hetkel on ettevõttel raha 22 miljardit ja pankrotti välja kuuluta pole plaanis. Vt. samas: Autsaiderite võidukäik; Koledada autod ja valed otsused

  16. Hérnia de disco cervical gigante: relato de caso

    OpenAIRE

    DANTAS FERNANDO LUIZ ROLEMBERG; FAGUNDES-PEREYRA WALTER JOSÉ; ROCHA DURVALINO LOPES; RASO JAIR L.

    1999-01-01

    As doenças do disco intervertebral são muito frequentes na prática neurocirúrgica. No Serviço de Neurocirurgia da Santa Casa de Belo Horizonte, em 1997, 17% das intervenções cirúrgicas foram por hérnia de disco, sendo 7% destas de localização cervical. Apresentamos um caso de hérnia de disco cervical volumosa em paciente de 72 anos, masculino, que apresentava tetraparesia espástica, com hiperreflexia, associada a hipoestesia superficial com nível sensitivo em C5 e retenção urinária. Foi subme...

  17. Acromegalic gigantism, physicians and body snatching. Past or present?

    NARCIS (Netherlands)

    W.W. de Herder (Wouter)

    2012-01-01

    textabstractThe skeletons of 2 famous acromegalic giants: Charles Byrne (1761-1783) and Henri Cot = Joseph Dusorc (1883-1912) and the embalmed body of the famous acromegalic giant Édouard Beaupré (1881-1904) all ended up in the medical collections of museums despite the fact that these patients had

  18. Growth hormone isoforms in a girl with gigantism.

    Science.gov (United States)

    Ng, L L; Chasalow, F I; Escobar, O; Blethen, S L

    1999-01-01

    Several previous investigations have suggested that there may be different growth hormone isoforms in patients with acromegaly. We used three different site-specific monoclonal antibodies (MAbs) to investigate growth hormone (GH) isoforms in serum from an 8 year-old girl with a GH and prolactin secreting adenoma. The pattern of GH-immunoreactivity was dependent on the circumstances of collection. Serum obtained after oral glucose had very little cross reactivity with MAb 352 although concentrations of up to 15 micrograms/l were found with two other MAbs, 033 and 665. MAb 352 does not recognize the 20,000 dalton isoform of GH (20K) while both MAb 033 and 665 do. The same pattern of GH immunoreactivity (low MAb 352, equal and higher MAb 033 and 665) was seen in other baseline samples. In contrast, samples obtained after TRH/GnRH showed immunoreactivity patterns expected for a mixture of 22,000 dalton isoform of GH (22K) with only a small amount of 20K. GH samples obtained during sleep showed both patterns with episodic peaks with equal immunoreactivity superimposed on the basal pattern (decreased activity with MAb 352). Affinity chromatography of basal samples showed that a portion of the GH immunoreactivity was neither 22K nor 20K, although in stimulated samples, over 70% of GH was 22K or 20K GH. In conclusion, the nature of GH isoforms present in serum varies with GH concentration. These differences may contribute to the known difficulty in correlating disease activity and random GH measurements in patients with GH secreting adenomas.

  19. Claudio Gigante - Dirk Vanden Berghe (eds., Il romanzo del Risorgimento

    Directory of Open Access Journals (Sweden)

    Marina Polacco

    2014-05-01

    Full Text Available A  lungo il dibattito storiografico sul Risorgimento è stato dominato dalla contrapposizione tra la retorica patriottica (la celebrazione della nascita della patria, il culto dei martiri e degli eroi risorgimentali e la denuncia dei limiti e delle inadempienze del processo di unificazione (la critica del Risorgimento come rivoluzione mancata, il riconoscimento della sostanziale immobilità delle strutture di potere, la questione meridionale. Parallelamente, in campo specificamente letterario il filone d’indagine più praticato è stato quello relativo alla narrativa ‘antirisorgimentale’ – sulla scia della celebre definizione di ‘romanzo antistorico’ coniata da Spinazzola a proposito di tre testi fondamentali nella rappresentazione del periodo storico in questione (e cioè I Vicerè, I vecchi e i giovani e Il gattopardo.

  20. Sarcoma de estroma prostático gigante

    Directory of Open Access Journals (Sweden)

    Jose Luis González González

    Full Text Available Los tumores de próstata representan la neoplasia maligna más frecuente en el varón. Mientras que las lesiones epiteliales son frecuentes, las neoplasias de origen mesenquimal representan entre 1 y 2 % de las neoplasias malignas prostáticas. Son poco conocidas, sobre todo las de origen estromal. Se presenta el caso de un varón de 77 años de edad, con un sarcoma del estroma prostático al que se le realiza una exéresis parcial. El tumor ocupa prácticamente la totalidad de la cavidad pélvico-abdominal, con un diámetro de 35 cm y un peso de 3 800 g. Histológicamente se concluyó, como sarcoma prostático aunque en el transoperatorio no se encontró un nexo evidente con este órgano. El comportamiento clínico de estos tumores, basado en los escasos casos descritos en la literatura, es prácticamente desconocido y su diagnóstico preoperatorio difícil. Este paciente se presentó con pérdida de peso, sin dolor, hematuria, ni síntomas obstructivos.

  1. Gigantic Copper-Molybdenum Mining Project Contract Signed in Guangdong

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    <正>With the reserves of nearly 1,000,000 tons of copper and approximately 250,000 tons of molybdenum and a total investment of RMB 5 billion, Guangdong Fengkai Yuanzhushan copper-molybdenum mining project contract was inked on October 13, 2011. It is reported that this is China’s second largest open-cast copper molybdenum mine next only to Dexing Copper Mine.

  2. Tratamento cirúrgico para adenocarcinoma colorretal gigante

    Directory of Open Access Journals (Sweden)

    Mauro Razuk Filho

    2014-10-01

    Full Text Available Introdução: O câncer colorretal acomete cerca de um milhão de pessoas a cada ano no mundo. Corresponde ao quarto tumor mais incidente nos homens e ao terceiro nas mulheres. A patogênese habitual de câncer colorretal é um pólipo adenomatoso que aumenta lentamente em tamanho, seguido pela displasia e, finalmente, o cancro. As diretrizes atuais descrevem diversas modalidades de tratamento cirúrgico do câncer de reto; Objetivos: O objetivo desse trabalho é relatar o caso de um paciente diagnosticado com adenocarcinoma de reto; Metodologia: O presente estudo foi embasado na análise do prontuário, das imagens obtidas por meio de exames subsidiários e do exame anatomopatológico; Relato do Caso: Paciente do sexo masculino, 77 anos. Apresenta queixa de sangramento anal assintomático há 20 anos e presença de lesão vegetante, de aproximadamente cinco centímetros, prolapsada pelo anus. O exame anatomopatológico comprovou o diagnostico de Adenocarcinoma de Reto. Foi realizada a Amputação Abdominoperineal do Reto. No segundo dia de pós-operatório, foi a óbito por parada cardiorrespiratória; Conclusões: O caso relatado descreve o tratamento cirúrgico dado à um paciente com o diagnostico de Adenocarcinoma esofágico que faleceu dois dias após a cirurgia;

  3. Aneurisma gigante del apéndice auricular izquierdo

    OpenAIRE

    Francisco L. Moreno-Martínez; González Alfonso,Osvaldo; Lagomasino Hidalgo,Álvaro L; González Díaz,Alejandro; Oliva Céspedes,Carlos; López Bernal,Omaida J

    2006-01-01

    Los aneurismas de la aurícula izquierda son raros y pueden ser congénitos o adquiridos. Los que interesan la pared libre o el apéndice auricular son entidades más raras aún, hasta 2002 sólo existían 49 casos reportados en la aurícula izquierda y 8 en la derecha. La manifestación clínica más frecuente es la aparición de arritmias auriculares incesantes o recurrentes y pueden presentarse embolias sistémicas que pueden dar al traste con la vida del paciente. Presentamos el caso de una paciente a...

  4. Benign or Malignant? Two Case Reports of Gigantic Prostatic Cyst

    Directory of Open Access Journals (Sweden)

    Jiang Yu

    2016-09-01

    Full Text Available A 60-year-old male with a huge prostate cyst presented with obstruction symptom of urethra and intestinal tract. Complete excision of the cystic prostate failed as a result of the strong adherence and twice operations history, but we confirmed prostate adenocarcinoma and relieved his obstruction symptom. Case 2 was a 77-year-old male with an 8 cm cyst of which biopsy showed prostate cancer in local hospital. He was admitted 18 months later because of intestinal obstruction. Radical resection had a satisfied result of obstruction symptom and PSA. Here we summarized malignant characteristics of cystic lesions in prostate or surrounding structures and management.

  5. Glassy protein dynamics and gigantic solvent reorganization energy of plastocyanin

    CERN Document Server

    LeBard, David N

    2007-01-01

    We report the results of Molecular Dynamics simulations of electron transfer activation parameters of plastocyanin metalloprotein involved as electron carrier in natural photosynthesis. We have discovered that slow, non-ergodic conformational fluctuations of the protein, coupled to hydrating water, result in a very broad distribution of donor-acceptor energy gaps far exceeding that observed for commonly studied inorganic and organic donor-acceptor complexes. The Stokes shift is not affected by these fluctuations and can be calculated from solvation models in terms of the response of the solvent dipolar polarization. The non-ergodic character of large-amplitude protein/water mobility breaks the strong link between the Stokes shift and reorganization energy characteristic of equilibrium (ergodic) theories of electron transfer. This mechanism might be responsible for low activation barriers in natural electron transfer proteins characterized by low reaction free energy.

  6. Síndrome de cauda equina por hernia discal gigante

    OpenAIRE

    Barriga, A.; Villas, C.

    2002-01-01

    La aparición de forma aguda o rápidamente progresiva de un cuadro de ciatalgia bilateral, con disminución completa de la fuerza de los pies y ocasionalmente del cuádriceps acompañado de retención y/o incontinencia urinaria e hipoestesia en silla de montar debe hacernos sospechar de la existencia de un síndrome de compresión de la cola de caballo, generalmente a causa de una hernia discal. Se trata de una urgencia quirúrgica absoluta en la patología del raquis. La identificación del síndrom...

  7. Tonsilolito gigante: a propósito de un caso

    OpenAIRE

    Silvestre Donat, Francisco Javier; Plá Mocholí, A.; Estellés Ferriol, José Enrique; Martínez Mihi, Victoria

    2005-01-01

    Los tonsilolitos son pequeñas concreciones calcificadas que se forman en las criptas de las amígdalas palatinas formados por sales cálcicas o en combinación con otras sales minerales y que suelen tener pequeño tamaño. En pocas ocasiones han sido descritos tonsilolitos de grandes dimensiones o en localizaciones periamigdalinas. Nosotros presentamos el caso de una mujer de 55 años de edad que tenía sintomatología de disfagia y molestias en la faringe con sensación de cue...

  8. Microphysics of Hardware or the Gigantism of the Infinitesimally Small

    OpenAIRE

    Ginosatis, Dimitris; Kavvathas, Dionyssis; Golemi, Anastazia

    2012-01-01

    International audience; Το παρόν κείμενο διάλεξης (5.000 λέξεις) εκφωνήθηκε στο πλαίσιο διεθνούς επιστημονικού συνεδρίου με θέμα: "Το νέο sensorium: ενσώματη αντίληψη, προεκτάσεις του ανθρώπου, ψηφιακή επικοινωνία", το οποίο διοργανώθηκε από το Τμήμα Επικοινωνίας, Μέσων & Πολιτισμού του Παντείου Πανεπιστημίου Κοινωνικών & Πολιτικών Επιστημών σε συνεργασία με το Πρόγραμμα Κοινωνίας & Τεχνολογίας και το Ινστιτούτο Coach House του Πανεπιστημίου του Toronto, και διεξήχθη στις 20 και 21 Απριλίου τ...

  9. Microphysics Of Hardware or The Gigantism Of The Infinitesimally Small

    OpenAIRE

    Ginosatis, Dimitris; Kavvathas, Dionyssis

    2012-01-01

    International audience; Το παρόν κείμενο διάλεξης (5.000 λέξεις) εκφωνήθηκε στο πλαίσιο διεθνούς επιστημονικού συνεδρίου με θέμα: Το Nέο Sensorium - Eνσώματη Aντίληψη, Προεκτάσεις του Ανθρώπου, Ψηφιακή Επικοινωνία, το οποίο διοργανώθηκε από το Τμήμα Επικοινωνίας, Μέσων & Πολιτισμού του Παντείου Πανεπιστημίου Κοινωνικών & Πολιτικών Επιστημών σε συνεργασία με το Πρόγραμμα Κοινωνίας & Τεχνολογίας και το Ινστιτούτο Coach House του Πανεπιστημίου του Toronto, και διεξήχθη στις 20 και 21 Απριλίου το...

  10. Influência do período de cultivo do capim-pé-de-galinha-gigante (Eleusine coracana na fitorremediação de solo contaminado com picloram Influence of Eleusine coracana cultivation period on phytoremediation of soil contaminated with picloram

    Directory of Open Access Journals (Sweden)

    M.L. Carmo

    2008-01-01

    Full Text Available O objetivo deste trabalho foi avaliar a influência do período de cultivo do capim-pé-de-galinha-gigante (Eleusine coracana sobre a fitorremediação de solo contaminado com picloram. O experimento foi conduzido em casa de vegetação, no período de setembro de 2006 a fevereiro de 2007. Os tratamentos foram compostos pela combinação entre quatro períodos de cultivo da espécie vegetal Eleusine coracana (0, 60, 80 e 100 dias e três doses do picloram (0, 80 e 160 g ha-1, totalizando 12 tratamentos. O delineamento experimental utilizado foi o inteiramente casualizado em esquema fatorial 4 x 3, com quatro repetições. Como substrato para o crescimento das plantas, utilizaram-se amostras de solo classificado como Latossolo Vermelho eutroférrico. Ao término do período estabelecido de atuação da espécie fitorremediadora, efetuou-se a semeadura das espécies bioindicadoras da presença do picloram: tomate (cultivar Santa Clara e soja (cultivar Monsoy 6101. As espécies bioindicadoras demonstraram alta sensibilidade à presença do picloram no solo, sendo inviável o cultivo dessas culturas em áreas contaminadas com esse herbicida sem a execução de algum procedimento remediador. O cultivo prévio de E. coracana por 60 dias reduziu a contaminação do solo com picloram e permitiu crescimento inicial satisfatório das plantas de soja e de tomate cultivadas em solo que recebeu previamente a aplicação de até 160 g ha-1 de picloram; contudo, essas plantas bioindicadoras apresentaram ainda sintomas visíveis de intoxicação do herbicida.The objective of this study was to evaluate the influence of Eleusine coracana cultivation period on phytoremediation of soil contaminated with picloram. The experiment was carried out at a greenhouse from September 2006 to February 2007, in 12 treatments combining four Eleusine coracana cultivation periods ((0, 60, 80 and 100 days and three picloram rates (0, 80 and 160 g ha-1, arranged in a completely

  11. Crescimento ponderal de filhotes de tartaruga gigante da Amazônia (Podocnemis expansa submetidos a tratamento com rações isocalóricas contendo diferentes níveis de proteína bruta Body growth of one-month giant Amazonian turtle (Podocnemis Expansa fed isocaloric diet with different levels of crude protein concentration

    Directory of Open Access Journals (Sweden)

    Vinicius Augusto Sá

    2004-12-01

    Full Text Available A criação de Podocnemis expansa, a tartaruga-da-amazônia, com finalidade comercial foi implantada no Brasil em 1992. Contudo, muitas questões acerca do manejo, da nutrição, da sanidade e, principalmente, da reprodução ainda são obscuras. Visando contribuir para o desenvolvimento de uma metodologia alimentar da espécie, objetivou-se testar diferentes níveis de proteína da dieta. Uma amostra de 480 animais neonatos de, aproximadamente, um mês de vida foram trazidos de uma área de proteção localizada no rio Araguaia no Estado Goiás para o Núcleo de Pscicultura Experimental/UFG. Os animais foram divididos em seis grupos de 80 animais e colocados em caixas de água de 500 litros. Cinco grupos receberam rações formuladas com diferentes teores de proteína bruta (PB vegetal: PB 18% (PB18, PB 21% (PB21, PB 24% (PB24, PB 27% (PB27 e PB 30% (PB30, enquanto o outro grupo (PBA30 recebeu ração comercial para peixes contendo proteína de origem animal (30% de PB. Bimestralmente, foram realizadas biometrias para determinação das medidas de comprimento (CC e largura da carapaça (LC, comprimento da carapaça (CP e largura do plastrão (LP e do peso corporal (PC. O experimento demonstrou superioridade do tratamento PBA30 em todas as medidas estudadas, seguidos seqüencialmente pelos tratamentos PB30, PB27, sem diferenças significativas entre estes grupos. Os piores resultados foram para os grupos PB24, PB21 e PB18, que não diferiam entre si. Filhotes de P. expansa nos dez primeiros meses de vida alimentados com dietas contendo elevados percentuais de proteína bruta (acima de 27% respondem melhor em termos de crescimento e ganho de peso que aqueles alimentados com dietas com percentuais mais baixos. A dieta contendo proteína bruta de origem animal apresentou melhores resultados que as de origem vegetal.The domestication of Podocnemis expansa (Gigant Amazonian turtle with commercial purpose it was implanted in Brazil in 1992. However, a

  12. Consumo e comportamento ingestivo de caprinos e ovinos alimentados com palma gigante (Opuntia ficus-indica Mill e palma orelha-de-elefante (Opuntia sp. - DOI: 10.4025/actascianimsci.v30i2.4684 Intake and ingestive behavior of sheep and goats fed with cactus pear (Opuntia ficus-indica Mill and prickly pear (Opuntia sp. - DOI: 10.4025/actascianimsci.v30i2.4684

    Directory of Open Access Journals (Sweden)

    Valéria Louro Ribeiro

    2008-08-01

    Full Text Available O presente trabalho teve por objetivo avaliar o consumo e comportamento ingestivo de caprinos e ovinos alimentados com palma Gigante (Opuntia fícus-indica Mill e palma Orelha-de-elefante (Opuntia sp.. Foram utilizados 20 animais mestiços, sendo dez caprinos e dez ovinos, alojados em galpão coletivo, contidos individualmente por meio de cordas, distribuídos em delineamento inteiramente casualizado, em um arranjo fatorial 2 x 2 (duas espécies animais e duas variedades de palma. As observações comportamentais foram realizadas em intervalos de 5 min. por um período de 24h. Os consumos de matéria seca, extrato etéreo, fibra em detergente ácido, carboidratos totais e carboidratos não-fibrosos foram menores (p 0,05 sobre o tempo gasto com alimentação e eficiência de alimentação. O tempo gasto com ruminação foi maior para a dieta com palma Gigante, consequentemente os animais da dieta com palma Orelha-de-elefante permaneceram mais tempo em ócio. Comparando as espécies caprina e ovina, verificou-se que a eficiência de ruminação, tanto de MS quanto de FDN, foi maior para a espécie ovina. Os animais gastaram mais tempo ruminando deitados do que em pé, mas não foi verificada diferença quanto ao lado escolhido para deitarem.The objective of this study was to evaluate the intake and ingestive behavior of sheep and goats fed with cactus pear (Opuntia ficus-indica Mill and prickly pear (Opuntia sp.. Twenty crossbred animals – 10 sheep and 10 goats – were used. They were lodged in a collective shed, contained individually with ropes, distributed using a completely randomized design, and treated with a 2 x 2 factorial arrangement (2 animal species and 2 varieties of cactus. Behavioral observations were made at five-minute intervals during a 24-hour period. Dry matter, ether extract, acid detergent fiber, total carbohydrate and non-fibrous carbohydrate intake were reduced (p 0.05 on feeding time and feeding efficiency. The time

  13. White matter cysts in patients with tuberous sclerosis; Quistes de sustancia blanca en pacientes con esclerosis tuberosa

    Energy Technology Data Exchange (ETDEWEB)

    Marti-Bonmati, L.; Dosda, R. [Hospital Universitario Dr. Peset. Servicio de Resonancia Magnetica ATQ-Quiron. Valencia (Spain); Menor, F. [Hospital Infantil La Fe. Valencia (Spain); Arana, E. [Hospital Casa de La Salud. Valencia (Spain); Poyatos, C. [Hospital Universitario Dr. Peset. Valencia (Spain)

    1999-07-01

    The presence of cysts in the white matter of the central nervous system of patients with tuberous sclerosis (TS) is an uncommon finding that has been reported only recently in neuroimaging studies. This article assesses the prevalence of these lesions in a large series of patients studied by magnetic resonance imaging (MRI) and their relationship to other epidemiological and imaging findings. MRI studies were performed in 46 patients (23 males and 23 females) with a mean age of 12.7 years, and the results were examined retrospectively in the search for cortical tubers, subependymal nodules and white matter nodules, lines and cysts. Nine patients (19.6%) presented cysts in white matter. Seven had only one cyst and the remaining two patients each had two. Multiple regression analysis relating the presence of the cysts with other neuroimaging findings in these patients revealed a statistically significant relationship only with white matter nodules (odds ratio: 7.5; p=0.006). White matter cysts are small, supratentorial lesions of deep location. There is a statistically relationship between the presence of these cysts and that of nodular lesions in the white matter. This finding supports the theory that the cyst originate from white matter nodules. (Author) 17 refs.

  14. Asociaciones de quistes de dinoflagelados de agua salobre a dulce de la formacion la colonia (Paleoceno?), Noreste de Patagonia, Argentina

    NARCIS (Netherlands)

    Guler, M. Verónica; Borel, C. Marcela; Brinkhuis, Henk; Navarro, Edgardo; Astini, Ricardo

    2014-01-01

    A palynological analysis of the section of La Colonia Formation exposed at Estancia San Miguel yielded conspicuous assemblages of organic-walled dinoflagellate cysts (dinocysts) and green algae. The monotypic palaeoperidinioid dinocyst assemblage of ?Ginginodinium sp. in the basal beds of this secti

  15. Congenital choledochal cyst: findings in US, CT and gammagraphy. Quiste congenito de coledoco: hallazgos en US, TC y gammagraphy

    Energy Technology Data Exchange (ETDEWEB)

    Montenegro Gaite, T.; Garrido Serrano, A.; Fernandez Cruz, J.; Gutierrez Martin, C.; Alcantara Gijon, F.; Leal Noval, M. (Hospital Universitario Virgen del Rocio. Sevilla (Spain))

    1993-01-01

    We report two cases of congenital choledochal cyst, the first signs of which were recurring episodes of nonspecific abdominal pain, accompanied by nausea and vomiting. The ultrasound (ES) study demonstrates the existence of an anechoic mass at the level of the hepatic hilus which, in one case, presents hyperechogenic zones with no posterior acoustic shadow. These findings were confirmed by means of computed tomography (CT). ''99 Tc-HIDA scintigraphy reveals a pronounced delay in the clearance of the tracer from the bile duct into duodenum, with late appearance of a cystic area at the level of the hepatic hilus. Endoscopical retrograde cholangiopancreatorgraphy (ERCP) performed in one of our patients shows, in addition to cystic dilation of the common bile duct, dilation of the cystic duct and of the common liver duct including its branches, as well as stenosis of the proximal duct of Wirsung, with dilation of its most distal portion. The purpose of this report is to assess the diagnostic methods employed and compare the results with the findings of other authors. (Author)

  16. Idiopathic Multilocular thymic Cyst: Presentation of 4 Cases in Adults; Quiste timico multilocular idiopatico: presentacion de cuatro casos en adultos

    Energy Technology Data Exchange (ETDEWEB)

    Yano, C.; Serrano Puche, F.; Padin, M.; Serrano Ramos, F. [Hospital Regional Carlos Haya. Malaga (Spain)

    2004-07-01

    Idiopathic multilocular thymic cysts are relatively rare entities found inside the anterior mediastinal masses. Most patients are asymptomatic. Accordingly, the discovery of such cysts are typically made by chance during the examination of routine chest X-rays performed for other reasons. On other occasions, patients may complain of such unspecific clinical symptoms as chest pain, cough breathing difficulty or fever. There are presented 4 multilocular thymic cyst cases in adult patients (2 women, 2 men) of patho-anatomical diagnosis. The findings described entail simple radiology. CAT, ultrasound scan in one case and MR in another. (Author) 6 refs.

  17. Growing skull fractures: occipital intradiploic extension of the leptomeningeal cyst; Fractura craneal evolutiva. Extension intradiploica occipital del quiste leptomeningeo

    Energy Technology Data Exchange (ETDEWEB)

    Escudero, R.; Perez, I.; Roldan, F.; Canabal, A. [Hospital Universitario Virgen de la Macarena. Sevilla (Spain)

    2001-07-01

    Growing skull fractures are very rare complications of childhood head injuries. Their early detection is essential in the attempt to prevent secondary cerebral atrophy. the most common site is the parietal or frontoparietal region. We present a case of growing skull fracture extending into the occipital diploid, space, an uncommon finding and unusual presentation of lesions of this type. In our patient, computed tomography provided the key to the diagnosis. (Author) 10 refs.

  18. Gela submarine slide: gigantic basin-wide event in the Plio-Quaternary foredeep of Sicily

    Energy Technology Data Exchange (ETDEWEB)

    Argnani, A.; Trincardi, F.

    1988-08-01

    The Gela basin is a Pliocene-Quaternary foredeep basin located at the front of the Maghrebian fold-thrust belt of Sicily, filled with 2,500 m-thick shallowing-upward marine sediments. An important contribution to the basin fill comes from a huge, basin-wide submarine slide which extends for 3,500 km/sup 2/ and thickens as much as 450 m; the estimated sediment volume involved in the slide is close to 1,000 km/sup 3/. The authors investigation used more than 3,000 km of multichannel and single-channel seismic reflection profiles. The slide depositional geometries and facies relationships have been reconstructed from seismic interpretation to provide insight into transport and emplacement mechanisms. Apparently, the slide was not simply deposited via mass transfer from the slope into the basin. Indeed, the bulk of the slide is composed of basin sediments plastically deformed under the gravitational force driven by the correspondent slope sediments. Such a deformation occurred above an extremely effective decollement surface which controlled the slide distribution throughout the basin. More localized decollement planes are, however, present within the slide body and contributed to its complex deformation. The slide can thus be considered the result of a generalized gravitational collapse which affected the sediments lying above a peculiar decollement horizon. A general uplift characterized the late Quaternary evolution of the area, and volcanic activity was quite widespread and documented in the historical record. A punctuated episode of energy release (volcanic related ), superimposed to the uplift trend, may have triggered the slide in conjunction with potentially easy detachment of a decollement.

  19. Abscesso cervical gigante provocado por sialolitíase de glândula submandibular

    Directory of Open Access Journals (Sweden)

    Fernanda Fruet

    2016-10-01

    Full Text Available Introdução: As infecções cervicais profundas apresentam alta mortalidade, apesar da eficácia da antibioticoterapia atual. Uma das principais complicações é a obstrução das vias aéreas superiores. A principal causa dessas infecções é de origem odontogênica e, raramente, a infecção das glândulas salivares. Objetivo: Apresentar um caso de abscesso cervical profundo, cuja etiologia rara está associada à sialolitíase com origem em glândula submandibular. Metodologia: O caso foi acompanhado no serviço de Cabeça e Pescoço do Conjunto Hospitalar de Sorocaba (CHS e sua descrição embasada na literatura. Relato de Caso: Paciente iniciou quadro de dor localizada em região submandibular posterior direita, acompanhada de disfagia e dispneia contínua. Procurou atendimento médico na cidade de origem, onde recebeu antibioticoterapia. Evoluiu com insuficiência respiratória, necessitando de transferência para o serviço de emergência do CHS aos cuidados da equipe de Cabeça e Pescoço. Ao exame físico, apresentava edema, abaulamento e hiperemia da lateral direita do pescoço. A Tomografia Computadorizada evidenciou abscesso em espaço retro-faríngeo com compressão da parede posterior da orofaringe e hipofaringe, além de glândula submandibular direita aumentada e imagem de cálculo. Foi realizada a traqueostomia e a resolução cirúrgica por meio da drenagem do abscesso através da incisão transversa em colar. Conclusão: O caso apresentado mostra um abscesso cervical profundo causado por etiologia incomum, a sialolitíase, cujo diagnóstico precoce, seguido do tratamento adequado, poderiam ter evitado a evolução grave do paciente. Neste caso, a drenagem cirúrgica precoce mostra sua importância na prevenção de insuficiência respiratória.

  20. Sulle Orme Del Gigante: Cristina Scarlat (A Cura Di, Mircea Eliade Once Again, Lumen, Iasi, 2011

    Directory of Open Access Journals (Sweden)

    Lara SANJAKDAR

    2012-09-01

    Full Text Available Negli ultimi anni il crescente interese per la persona e l’opera di Mircea Eliade ha originato una vera e propria esplosione di pubblicazioni dedicate allo studioso, e anche la comparsa postuma di molti scritti inediti. Alcune di questi lavori, peraltro di rilievo, sono apparsi in occasiione delle celebrazioni del ventennale della morte dell’ intelectuale romeno (2006, altre ancora in tempi recentissimi non soltano in Italia, ma anche in Romania, Germania, Stati Uniti d’America, Spagna e Russia.