WorldWideScience

Sample records for quer mal nos

  1. TV Programme Presentations: Kreuz und Quer

    CERN Multimedia

    CERN Bulletin

    2011-01-01

    TV Programme Presentations: Kreuz und Quer: Im Anfang war das Teilchen-CERN und die Frage nach Gott by ORF (2010) and Faszination Wissen: CERN-LHC by Bayerisher Rundfunk (2010)   ORF’s Kreuz und Quer: Im Anfang war das Teilchen-CERN und die Frage nach Gott presents a debate on science and religion and their relationship. The film by Stefanie Mahler and Niki Popper leads a discussion between physicists and theologians on the basis of such questions as what role does coincidence play vs. what is the human responsibility and whether there is a place for God between all these questions and answers. Even in these modern times, 80% of the mass distributed in the universe is made of an unknown origin. Bayerisher Rundfunk’s Faszination Wissen: CERN-LHC, CERN physicists explain the exciting physics searches underway at the Large Hadron Collider. By colliding protons that have been accelerated to almost the speed of light, the LHC is able to create the conditions that existed just after th...

  2. Grand Mal Seizure

    Science.gov (United States)

    ... grand mal seizures include: A family history of seizure disorders Any injury to the brain from trauma, a ... the risk of birth defects. If you have epilepsy and plan to become pregnant, work with your ...

  3. Estrategia explotadora en juegos de póquer

    OpenAIRE

    Velmer Montoliu, Marc

    2016-01-01

    El objetivo de este proyecto es estudiar el comportamiento de jugadores de póquer online a través de la información que obtenemos de su historial de juego y obtener una estrategia explotadora que pueda aprovecharse de las debilidades de los rivales en base a un cálculo estadístico.

  4. Gupta, Dr Chhitar Mal

    Indian Academy of Sciences (India)

    Gupta, Dr Chhitar Mal Ph.D. (Agra), FNA, FNASc, FAMS, FTWAS Council Service: 1998-2000. Date of birth: 1 September 1944. Specialization: Membrane Biology, Bio-organic Chemistry and Molecular Biophysics Address: Distinguished Professor and Infosys Chair, Institute of Bioinformatics & Applied Biotechnology, Room ...

  5. Mal de terre

    CERN Document Server

    Reeves, Hubert

    2003-01-01

    Notre planète va mal: réchauffement climatique, épuisement des ressources naturelles, pollutions des sols et de l'eau provoquées par les industries civiles et guerrières, disparité des richesses, malnutrition des hommes, taux d'extinction effarant des espèces vivantes, etc.

  6. Memoria del mal

    Directory of Open Access Journals (Sweden)

    Semprún, Jorge

    2011-06-01

    Full Text Available In May 2003 the twelfth edition of the «Aranguren Conferences» was held. Jorge Semprún gave three keynote speeches titled «Kant and the Maquis’ rucksack», «The radical evil and the Buchenwald latrines» and «Literature and memory of the evil: from Sartre to Paul Ricoeur», all of them grouped under the generic denomination Memory of Evil. The thread running through the three speeches was Semprún’s experience as a political deportee at Buchenwald concentration camp, so close to the Weimar camp of Schiller and Goethe. There, he could experience the radical evil, but also the brotherhood through the antifascist resistance groups who coordinated the various clandestine political groups at the camp. This experience helped him review some of the philosophical readings he had done as a philosphy student at the Sorbonne, as well as those readings he took an interest in following the end of the war. In this way, Semprún went over various authors (Immanuel Kant, André Malraux, Edmund Husserl, Jacques Maritain, Martin Heidegger, Karl Marx, Hannah Arendt, Jean Paul Sartre, Paul Ricoeur or Primo Levi arguing their relationship with the issue of Evil.

    En mayo de 2003 se celebró la duodécima edición de las «Conferencias Aranguren». Jorge Semprún dictó tres conferencias magistrales tituladas «Kant y la mochila del maquis», «El mal radical y las letrinas de Buchenwald» y «Literatura y memoria del mal: de Sartre a Paul Ricoeur», agrupadas todas ellas bajo el título genérico de Memoria del mal. El hilo conductor de las tres intervenciones fue la experiencia de Semprún como deportado político en el campo de concentración de Buchenwald, tan cercano al Weimar de Schiller y Goethe. Allí pudo experimentar el mal radical, pero también la fraternidad, a través de los grupos de resistencia antifascista que coordinaban en el campo los distintos grupos políticos clandestinos. Esta experiencia le sirvió para repasar las lecturas

  7. Caracterização das epidemias de malária nos municípios da Amazônia Brasileira em 2010 Caracterización de las epidemias de malaria en los municipios de la Amazonia brasileña en 2010 Characteristics of malaria epidemics in the municipalities of the Brazilian Amazon, 2010

    Directory of Open Access Journals (Sweden)

    Pedro Luiz Tauil

    2013-05-01

    Full Text Available Epidemias de malária ocorrem anualmente nos municípios da Região Amazônica, Brasil, no entanto os serviços de saúde não adotam, de maneira sistemática, instrumentos para detecção e contenção oportunas desses eventos. O objetivo foi caracterizar as epidemias de malária na região segundo duração, espécie de Plasmodium e vulnerabilidade das populações. Foi avaliado um sistema de monitoramento automatizado da incidência da malária, com base no diagrama de controle segundo quartis, para identificar as epidemias da doença. Em 2010, ocorreram epidemias em 338 (41,9% municípios da região. Houve epidemias por P. falciparum e por P. vivax, separadamente, e também por ambas as espécies. Epidemias com duração de um a quatro meses ocorreram em 58,3% dos municípios epidêmicos; de cinco a oito meses, em 24,3%; e de nove a 12 meses, em 17,4%. O monitoramento automatizado da variação da incidência da malária poderá contribuir para detecção precoce das epidemias e melhorar o seu controle oportuno.Las epidemias de malaria ocurren anualmente en los municipios de la Región Amazónica, Brasil, no obstante, los servicios de salud no adoptan de manera sistemática instrumentos para la detección y contención oportuna de este tipo de eventos. El objetivo fue caracterizar las epidemias de malaria en la región según su duración, especie de Plasmodium y vulnerabilidad de las poblaciones. Se evalúo un sistema de supervisión automatizado de la incidencia de la malaria, en base al diagrama de control según cuartiles, con el fin de identificar las epidemias de la enfermedad. En 2010, se produjeron epidemias en 338 (41,9% municipios de la región. Hubo epidemias por P. falciparum y por P. vivax, separadamente, y también por ambas especies. Hubo epidemias con una duración de uno a cuatro meses que se produjeron en un 58,3% de los municipios epidémicos; de cinco a ocho meses, en un 24,3%; y de nueve a 12 meses, en un 17,4%. La

  8. El Gobierno del mal menor

    DEFF Research Database (Denmark)

    Agustin, Oscar Garcia

    2012-01-01

    El Gobierno no aspira a ser bueno ni malo. Se conforma con ser el Gobierno del mal menor, cuyas medidas drásticas y poco populares están destinadas a salvar a los ciudadanos del desastre que no ha llegado todavía pero podría llegar....

  9. Estados de mal epiléptico na sindrome Delennox-Gastaut: aspectos terapeuticos

    Directory of Open Access Journals (Sweden)

    José Geraldo Speciali

    1977-09-01

    Full Text Available Foram descritas as condutas terapêuticas utilizadas nos estados de mal epiléptico, convulsivos e não convulsivos, observados em 14 pacientes com síndrome de Lennox-Gastaut. Verificou-se relação temporal entre aparecimento de estado de mal epiléptico e início de tratamento com clonazepam e difenilhidantoina; a retirada dessas medicações foi seguida pelo desaparecimento dos estados de mal. Indicou-se a possibilidade de tratamento dos estados de mal epiléptico modificando-se o esquema terapêutico administrado por via oral, reservando-se o tratamento parenteral para os estados com comprometimento progressivo da consciência e/ou dos distúrbios neurovegetativos.

  10. O conceito de mal radical The concept of radical evil

    Directory of Open Access Journals (Sweden)

    Adriano Correia

    2005-01-01

    Full Text Available A noção de mal radical aparece em Kant no contexto da discussão da religião nos limites da simples razão e busca dar conta da complexa relação entre o respeito pela lei moral e o amor-próprio na definição do móbil para a ação. Na busca por identificar o fundamento da propensão para o mal no homem, Kant se vê diante da dificuldade de ter de articular natureza e liberdade, e ainda que a noção de mal radical possa conservar algumas ambigüidades, permite conceber uma noção de responsabilidade compatível com uma inata propensão para o mal. Neste texto busco explicitar alguns passos fundamentais na construção do conceito por Kant.The concept of radical evil appears in Kant's theory when he discusses the religion in the limits of the mere reason and aims explain the complex relationship between respect for the moral law and the self-love, for establish the motive of the action. By aiming identify the basis of human inclination to evil, Kant is faced with the trouble of have to put nature and freedom in connection. Despite of the concept of radical evil retain some ambiguity, it allows conceive a notion of responsibility suitable to an inherent inclination to evil. In this paper is my purpose to explain some basic moments of Kantian formulation of that notion.

  11. A new species of Otatea (Poaceae: Bambusoideae: Bambuseae) from Querétaro, Mexico

    OpenAIRE

    Ruiz-Sánchez, Eduardo

    2012-01-01

    Based on recent systematic studies of the genus Otatea, that included an extensive taxonomic investigation of herbaria specimens, and recent fieldwork in the Mexican state of Querétaro, a new Otatea species, O. ramirezii, is here described and illustrated. The new species is endemic to the Sierra Gorda in Querétaro, Mexico. It is compared with Otatea acuminata, O. carrilloi and O. glauca, from which it can be separated by the presence of only one (rarely two) branches per node, erect culm lea...

  12. Arendt, Eichmann y la banalidad del mal

    Directory of Open Access Journals (Sweden)

    López, Marina

    2010-04-01

    Full Text Available In this text I describe the characteristics that Hannah Arendt attributes to the SS agents through the figure of Eichmann, during the German Nazi regime of the 20th century. According to this characterization, I intend to show, on the one hand, that there is not a break in Arendt’s thought on evil, i.e. from The Origins of Totalitarianism to Eichmann in Jerusalem: a report on the banality of evil, but a continuous line of thought. And, on the other hand, I try to follow the clues that Arendt gives concerning the “banality” that defines the behavior of individuals such as Eichmann. Both premises will permit me to point out what, in my understanding, the banalization of humanity implies, not only in the context of the Jewish Holocaust, but in each of the societies in which the elimination of spontaneity is a reality.

    En el texto se describen las características que Hannah Arendt, a través de la figura de Eichmann, atribuye a los agentes SS durante el régimen nazi alemán de mediados del siglo XX. Con la caracterización se persigue mostrar, en principio, que no hay una ruptura en el pensamiento de Hannah Arendt respecto a su manera de considerar el mal, desde Los orígenes del Totalitarismo hasta Eichmann en Jerusalén, un estudio sobre la banalidad del mal, sino una continuidad y, por otra parte, seguir las pistas que Arendt propone en torno a la “banalidad” que define el comportamiento de individuos como Eichmann. Ambas premisas nos permitirán poner de relieve lo que, a nuestro parecer, implica la banalización de la humanidad no sólo en el contexto del Holocausto judío, sino en cada una de las sociedades en las que la eliminación de la espontaneidad es una realidad.

  13. El problema del mal y la violencia en Colombia

    Directory of Open Access Journals (Sweden)

    Victor Eligio Espinosa Galán

    2015-09-01

    Full Text Available La historia de la humanidad está marcada por conflictos de distinta naturaleza: religiosos, ideológicos, raciales, etc., expresados en guerras, ataques terroristas, masacres, entre muchas otras situaciones de crueldad que muestran maldad y sevicia ejercida sobre seres humanos. Ante estos acontecimientos que nos enfrentan a la pregunta: ¿qué es aquello que nos hace humanos?, parece, en un contexto como el colombiano, que se asiste a formas oficiales de una agencia de maldad como posibilidad de un ethos cultural que hace plausibles las acciones más perversas en una desoladora minimización de responsabilidad moral, necesaria para construcción de una sociedad justa y en paz. Este escrito es un esfuerzo por pensar el problema del mal en el contexto de la violencia en Colombia y dar cuenta de algunos aspectos de la reflexión filosófica sobre el mal, el sufrimiento y el sentido de la vida; se toma como contexto el conflicto armado en Colombia y las narraciones de sus protagonistas.

  14. Greenhouse designs for Mexico. Aguascalientes, Querétaro and Sinaloa

    NARCIS (Netherlands)

    Elings, A.; Speetjens, S.L.; Garcia Victoria, N.

    2014-01-01

    This study reports on the environmental and economic impacts of greenhouses with different technological levels in the states of Aguascalientes, Querétaro and Sinaloa in Mexico. Seven technology levels were evaluated, varying in the type of substrate, covering material, heating, CO2 enrichment,

  15. Literacia em diabetes nos alunos do ensino superior público do concelho de Mirandela

    OpenAIRE

    Neto, Alexandra Marisa Maia Alves

    2016-01-01

    A literacia em diabetes parece ser uma das ferramentas fundamentais para combater o aumento de prevalência desta patologia crónica que tem crescido exponencialmente ao longo dos anos quer a nível mundial, quer a nível nacional. Com este estudo pretendeu-se avaliar o nível de literacia em diabetes nos estudantes do ensino superior público do concelho de Mirandela, para, em consequência, fornecer algumas diretrizes para a proposta de um projeto de intervenção nesta comunidade. Teve como objetiv...

  16. Breeding Fulvous Whistling-Ducks and other notes on the birds of Querétaro’s reservoirs

    Directory of Open Access Journals (Sweden)

    Jonathan Hiley

    2013-07-01

    Full Text Available I present a noteworthy breeding record for the state of Querétaro in central Mexico. In addition, I demonstrate records of six species which have not previously been documented in the state. All were seen on a series of reservoirs in the lower half of the state. These further additions to the Querétaro avifauna confirm the importance of these water bodies to a wide range of species.

  17. El mal de ojo en Toledo

    OpenAIRE

    Salvador Hernández, Pedro Pablo

    2017-01-01

    La presente tesis doctoral estudia el fenómeno del Mal de Ojo en la provincia de Toledo desde una perspectiva antropológica. El trabajo se estructura en tres partes. Por un lado, se analiza el marco general de la antropología médica, la medicina popular, el curanderismo y los síndromes culturales. Por otro lado, se aborda el fenómeno del Mal de Ojo, analizando los síntomas, la etiología, el tratamiento y la prevención de esta enfermedad cultural. La tercera parte recoge cuatro estudios de cas...

  18. Analysis of refrigerant mal-distribution

    DEFF Research Database (Denmark)

    Kærn, Martin Ryhl; Elmegaard, Brian

    2009-01-01

    to be two straight tubes. The refrigerant maldistribution is then induced to the evaporator by varying the vapor quality at the inlet to each tube and the air-flow across each tube. Finally it is shown that mal-distribution can be compensated by an intelligent distributor, that ensures equal superheat...

  19. Indigenous insurgents in the Huastecas and the city of Querétaro

    Directory of Open Access Journals (Sweden)

    Antonio ESCOBAR OHMSTEDE

    2011-04-01

    Full Text Available This article presents the way in which indigenous insurgencies in the Huastecas and in the city of Querétaro originated, developed and died out. Different types of responses from the groups affected by the insurgent war unleashed in September 1810 emerged in these dissimilar areas, interconnected however by commercial activities and personal relations. According to the authors, the reasons for taking one or other of the sides in the dispute lay in the economic activities prior to the war, as well as in the different forms of settlement in the areas under study. The varying support given by the indigenous governments to the belligerent sides was therefore gained through negotiation with native authorities, conviction, or simple coercion, and the formation of varied troops contributed to breaking the ethnical social stratification of the viceroyal times. Although it is true that in the insurgencies in the Huastecas and in Querétaro we find contrasting aspects, Spanish authorities supported by the companies of Patriots loyal to the Crown prevailed because they prevented the different groups of insurgents in the rural field from coming together with those from urban extraction, and vice versa.

  20. Kewenangan Baitul Mal Aceh dalam Pendistribusian Zakat

    Directory of Open Access Journals (Sweden)

    Surya Darma

    2017-08-01

    ABSTRACT: Aceh is a province in Indonesia that is granted a special authority to govern and manage its own government affairs. One of them is zakat as one of the original source of income. Baitul Mal institution is established by qanun (local law to manage the zakat fund. In regard with its management procedure as the original revenue of the area, which is managed by Baitul Mal, is regulated in qanun and governor regulation. Its expenditure or distribution is in accordance with the guidance of the Islamic Sharia, that is, it may only be the part specified in the Qur'an, not for others. One of the forms of its distributions’ forms is the provision of vocational capital to productive zakat recipients through Productive Zakat Management Units. It is done in the form of interest-free loans. It is slightly different, as the zakat must be divided in full without needing to be returned. Although its interest-free loan is legal, it requires further explanation to avoid negative views. The finding shows that in 2013, 2014 and 2015, Baitul Mal Aceh, gains its funds more than expected. It requires careful handling in order to avoid  any problems in the future.

  1. Mal, daño y justicia

    Directory of Open Access Journals (Sweden)

    Carlos THIEBAUT

    2009-11-01

    Full Text Available RESUMEN: Algunas experiencias del siglo XX -Auschwitz, el Gulag, Hiroshima- han vuelto a herir la conciencia ilustrada y replanteado el problema del mal en nuestra cultura. Más que una indagación metafísica sobre la naturaleza del mal, el artículo aboga por un análisis de cómo llegamos a elaborar su experiencia, un proceso que aquí prefiere concebirse como una indagación en torno al daño. Se analizan las estructuras conceptuales, modales y temporales de esa experiencia y, en la segunda parte, se propone la idea de que la elaboración pública del daño es una clave para comprender la dimensión normativa del espacio público.ABSTRACT: Some experiences of the Twentieth Century have, yet again, wounded the Enlightment program and have rephrased the problem of evil in our culture. The article avoids a metaphysical inquiry into the essence of evil and proposes an analysis of how we come to work and elabórate its experience, a process that is here understood as the experience of harm. Its conceptual, modal and temporal structures are analysed and, in its second part, the idea that the public labouring of harm is a clue to understanding the normative dimensión of the public sphere is proposed.

  2. Adiciones al inventario avifaunístico del estado de Querétaro, México

    Directory of Open Access Journals (Sweden)

    José Belem Hernández-Díaz

    2015-01-01

    Full Text Available Reportamos por primera vez nueve especies de aves para el estado de Querétaro, México, cinco de ellas nativas (Cyrtonyx montezumae, Buteo lineatus, Phalaropus fulicarius, Falco mexicanus e Icterus spurius y cuatro introducidas (Streptopelia roseogrisea, Cyanoliseus patagonus, Amazona finschi yCalocitta colliei. El inventario avifaunístico del estado incluye ahora 430 especies, de las cuales 418 son nativas y 12 introducidas. Consideramos que el estudio de la avifauna en la zona oeste de Querétaro, que corresponde a la Faja Volcánica Transmexicana, se ha venido completando en los últimos años con un importante esfuerzo de muestreo, por lo que con los presentes registros se conocen 271 especies de aves en ella.

  3. [Unit cost variation in a social security company in Querétaro, México].

    Science.gov (United States)

    Villarreal-Ríos, Enrique; Campos-Esparza, Maribel; Garza-Elizondo, María E; Martínez-González, Lidia; Núñez-Rocha, Georgina M; Romero-Islas, Nestor R

    2006-01-01

    Comparing unit cost variation between departments and reasons for consultation in outpatient health services provided by a social security company from Querétaro, Mexico. A study of costs (in US dollars) was carried out in outpatient health service units during 2004. Fixed unit costs were estimated per department and adjusted for one year's productivity. Material, physical and consumer resources were included. Weighting was assigned to resources invested in each department. Unit cost was estimated by using the micro cost technique; medicaments, materials used during treatment and reagents were considered to be consumer items. Unit cost resulted from adding fixed unit cost to the variable unit cost corresponding to the reason for consulting. Units costs were then compared between the medical units. Unit cost per month for diabetic treatment varied from 34.8 US dollars, 32,2 US dollars to US 34 US dollars, pap smear screening test costs were 7,2 US dollars, 8,7 US dollars and 7,3 US dollars and dental treatment 27 US dollars, 33 US dollars, 6 and 28,7 US dollars. Unit cost variation was more important in the emergency room and the dental service.

  4. A german vision of urban models. The case of Querétaro

    Directory of Open Access Journals (Sweden)

    Christof Göbel

    2015-08-01

    Full Text Available Due to their complexity, the organization, function and morphology of cities has been historically reduced to graphic abstractions or urban “models” with the intention to identify types of cities according to the cultural space in question. However, by their nature, cities are under constant change and transformation, which gives rise to many questions about the validity and the relevance of these urban models: Are these models still a way to understand the logic and structure of cities? Can we understand urban morphology through these schemes? Are there urban models to understand a “medium sized” city? Departing from these questions, the aim of this article is to explore whether current urban models continue corresponding with the morphology and structure of a city, and with the changes that occur in them in a ten-year period, as it is the case of the city of Querétaro.

  5. Expansion dispersa, ciudad difusa y transporte: el caso de Querétaro, México

    Directory of Open Access Journals (Sweden)

    Carlos Martner

    2016-01-01

    Full Text Available A partir de la discusión conceptual sobre las tendencias de concentración y dispersión espacial en las fases recientes de desarrollo capitalista y la transformación de las relaciones entre lo urbano y lo rural, se analiza el papel que desempeñan las redes de transporte en los nuevos patrones de ordenación del territorio de una ciudad intermedia mexicana (Querétaro, caracterizada por la expansión difusa de su zona metropolitana. Este proceso involucra un vínculo creciente con localidades rurales (microrregión Navajas-Galera, las mismas que han visto modificarse aceleradamente su entorno en los últimos quince años, por el asentamiento progresivo y discontinuo de actividades industriales y de servicios en el territorio. El método de análisis, basado en un enfoque estructural-sistémico, muestra el progresivo desvanecimiento de la división conceptual tajante establecida tradicionalmente entre el campo y la ciudad. Asimismo, constata que el desarrollo de los sistemas de transporte regional constituye un elemento estratégico de articulación espacial en esta nueva configuración territorial ampliada, donde la intensificación de la movilidad es sustantiva.

  6. Registros nuevos y notables de aves acuáticas en Querétaro y estados adyacentes

    Directory of Open Access Journals (Sweden)

    Rubén Pineda-López

    2013-01-01

    Full Text Available Como resultado de muestreos mensuales durante un año en embalses de Querétaro y zonas adyacentes de estados vecinos, así como de visitas a la Sierra de Lobos en Guanajuato, presentamos nuevos registros estatales de aves acuáticas para los estados de Querétaro (Bucephala albeola, Fregata magnificens, Numenius americanus, Hidalgo (Charadrius semipalmatus, Leucophaeus atricilla, Hydroprogne caspia y Guanajuato (Pelecanus occidentalis; además de registros notables de especies poco conocidas en zonas alejadas de las costas mexicanas. Estos registros muestran que los embalses de zonas semiáridas altas de México son más utilizados por especies poco frecuentes que lo que se ha pensado, y elevan a 70 las especies observadas en la zona semiárida de Querétaro, lo que confirma la importancia de los cuerpos de agua artificiales de esta región para la conservación de las aves acuáticas.

  7. Sobre a psicogênese do "mal de engasgo"

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    Durval Marcondes

    1947-06-01

    Full Text Available O A. ressalta o aspecto psicológico da etiologia do cardiospasmo ou mal de engasgo, assunto até agora não abordado nos meios científicos brasileiros. Sem pretender afastar outros elementos causais que tenham sido, porventura, verificados e que poderão, talvez, agir concomitantemente, o A. é de opinião que o mal de engasgo é um disturbio funcional condicionado psìquicamente, cujas conseqüências se tornam irreversíveis depois de certo tempo. As conclusões apresentadas baseiam-se no material fornecido por pacientes em tratamento psicanalítico que apresentam fenômenos disfágicos, e por vários casos das clínicas de orientação infantil entre cujos problemas se incluem, além da dificuldade de engulir, a anorexia e a bulimia. Com respeito às atividades emocionais típicas que formam o substrato psicológico do mal de engasgo, o ponto fundamental está em que êste representa um compromisso, expresso ao nível oral, entre tendências passivo-receptivas e ativo-expulsivas. A essa situação psíquica correspondem condições de ambiente, atuais ou pretéritas, que, de modo contraditório, favorecem uma atitude de dependência infantil, ao mesmo tempo que acarretam repetidas frustrações. Trata-se, em geral, de mães dominadoras que, enquanto superprotegem a criança, agem para com ela com demasiado rigor. A superproteção centraliza-se sobretudo no que se refere aos alimentos, que se investem, assim, de grande significado emocional. O A. apresenta o resumo de uma observação clínica que apoia seu ponto de vista. Também a anorexia e a bulimia, em seu substrato psicodinâmico, estão relacionadas com o problema do apego e da emancipação e giram em torno da pessoa da mãe e da função alimentar. A solução do conflito faz-se, porém, num dos casos, pela rejeição do alimento e, noutro, pela avidez. O mal de engasgo constitui o meio têrmo entre os dois extremos. Existem, igualmente, nas neuroses gástricas e em sua conseq

  8. Savoir gérer le mal

    Directory of Open Access Journals (Sweden)

    Michel Maffesoli

    2015-09-01

    Full Text Available Le sens commun, conservatoire immémorial de la sagesse humaine « sait », de savoir incorporé, que le mal, l’ombre, la mort, la douleur sont des caractéristiques essentielles de l’existence en son entièreté. Dès lors les créatures quelles qu’elles soient, sont des manifestations de la vie et, dès lors, méritent une attitude « compassionnelle », fraternelle, parce qu’ensemble elles constituent le flux vital. C’est ainsi que l’on peut comprendre l’utilité sociale de ces divers « mondes intermédiaires » que sont les croyances, religieuses ou philosophiques, au « double », au « daimon », aux esprits et autres figures tutélaires ou effrayantes. Elles aident à vivre, au jour le jour, la souffrance en la communalisant.

  9. Situação da malária na tríplice fronteira entre Brasil, Colômbia e Peru

    Directory of Open Access Journals (Sweden)

    Paulo César Peiter

    2013-12-01

    Full Text Available O objetivo deste artigo é analisar a situação da vigilância da malária na tríplice fronteira entre Brasil, Colômbia e Peru. É um estudo qualitativo com aplicação de questionários em cidades da fronteira realizado em 2011. Os resultados foram analisados pela metodologia DOFA e apontaram diferenças significativas entre os sistemas de vigilância da malária na fronteira. Observou-se como debilidades a desarticulação entre atores responsáveis, a insuficiência de pessoal treinado, a alta rotatividade das equipes e a falta de médicos especialistas em malária nos hospitais locais. Verificou-se ainda o desconhecimento sobre a malária e suas formas de prevenção na população entrevistada. As fortalezas são a inserção de novos atores institucionais, a melhora da qualificação profissional, a distribuição de mosquiteiros impregnados e possibilidades de complementaridade entre os sistemas de vigilância a serem aproveitadas pela cooperação entre as equipes de saúde da fronteira, pois o controle da malária só pode ter sucesso tomando-se esta região em seu conjunto.

  10. Le mal de Pott: à propos de 82 cas

    Directory of Open Access Journals (Sweden)

    Badr Fedoul

    2011-03-01

    Full Text Available Nous rapportant dans cette étude, les résultats de l’expérience du service de neurochirurgie du CHU Hassan II de Fès dans la prise en charge du mal de pott dans la région de Fès. Il s’agit d’une étude rétrospective de quatre-vingt-deux cas; étalée sur une période de cinq ans (janvier 2002 au décembre 2006. L’objectif de ce travail était d’illustrer les différents aspects épidémiologiques, diagnostiques et thérapeutiques de la localisation vertébrale de la tuberculose dans notre pratique. L'âge moyen de nos patients était de 43,1 ans, avec une légère prédominance féminine (53,82%. La durée d'évolution de la maladie était longue (dix mois en moyenne; ceci est expliquée par la symptomatologie initiale insidieuse faite de rachialgies (98,78% et une admission des patients au stade de complications neurologiques (41,46%. La radiographie standard était réalisée chez tous nos patients, et complétée par la TDM dans 86.58% des cas ce qui a permis de déceler la prédominance de l'atteinte dorsale et lombaire. L'IRM est l'examen de choix, elle était demandée chez tous les malades déficitaires (37,8%.Tous nos patients ont bénéficié d'un traitement antibacillaire associé à une immobilisation du foyer pottique. Une décompression par voie antérieure était réalisée chez 29 patients (35,36 %; alors que la laminectomie n'était pratiquée que chez 5 patients (6.09 %, tandis que l'évacuation de l'abcès de psoas était réalisée chez 25 patients (30,48 %. Le diagnostic de certitude histologique était posé dans 51 cas (62,19%. Les meilleurs résultats étaient obtenus chez les malades opérés par voie antérieure, 26 cas (89,65% de récupération totale et 3 cas (10,34% partielle. L'évolution vers la consolidation et la fusion vertébrale était la règle chez tous nos malades et ceci au bout de 4 à 18 mois après le traitement.

  11. Intestinal mal-rotation in adults. CT findings

    International Nuclear Information System (INIS)

    Vazquez Munoz, Enrique; Ramiro Ramiro, Esther; Perez Villacastin, Benjamin; Learra Martinez, Maria C.; Franco Lopez, Maria A.

    2004-01-01

    We review 7 adult cases of intestinal mal-rotation who were studied with CT. All patients had a small bowel located in the right hemi abdomen, abnormal location of superior mesenteric vein relative to superior mesenteric artery. Superior mesenteric vein was located anteriorly and to the left of superior mesenteric artery. In patients who suffered intestinal volvulus a 'whirlpool' sign was observed, due to the helicoidal torsion of the intestine and mesentery surrounding superior mesenteric artery. In 3 cases CT demonstrated absence or poor development of the pancreas uncinate process. In 2 patients CT revealed polysplenia. CT played a major role in 3 patients with volvulus as a complication of intestinal mal-rotation. CT also demonstrated unsuspected mal-rotation in one asymptomatic patient. In 3 cases with classic symptoms CT confirmed the intestinal mal-rotation diagnosed by barium studies. (author)

  12. PENGARUH KEBUDAYAAN KONTEMPORER DALAM PERANCANGAN ARSITEKTUR MAL

    Directory of Open Access Journals (Sweden)

    Freddy H. Istanto

    2000-01-01

    Full Text Available Market is traditionally known as the place where the seller and the buyers meet. In its development, it grows to be big shopping centers and even malls. Along with it, the concept of market has also changed within this building. It is not only the place where the transaction between the sellers and the buyers happen but also it expands to be the one where each person has turned to be the "player" in the nowadays "cultural-theatre". Being the designers, the architect is challenged to respond the changing pattern in the society by making use of the building. Abstract in Bahasa Indonesia : Pasar dikenal sebagai tempat dimana penjual dan pembeli bertemu. Dalam perkembangan lebih lanjut muncul pusat-pusat pertokoan yang sangat besar sampai hadirnya shopping-mall. Di dalam bangunan inilah konsep pasar secara tradisional telah berkembang, tidak saja tempat transaksi antara penjual dan pembeli, tetapi telah melebar menjadi tempat dimana setiap individu telah menjadi "pemain" di dalam sebuah teater kebudayaan masa kini. Arsitek sebagai perancang bangunan harus menyikapi perubahan-perubahan perilaku yang terjadi di masyarakat dalam menggunakan bangunannya. Kata kunci: kebudayaan kontemporer, arsitek, arsitektur mal, kebudayaan milenium tiga.

  13. Desarrollo general agropecuario y forestal del estado de Querétaro en el periodo 1930-1960

    Directory of Open Access Journals (Sweden)

    Elizabeth Holt Büllner

    1970-01-01

    Full Text Available El estado de Querétaro situado en la Meseta Central de la República Mexicana, está limitado por cinco Estados: San Luis Potosí al norte y noreste, Hidalgo al este, Guanajuato al oeste y suroeste y México y Michoacán al sureste y sur respectivamente. Está localizado geográficamente entre los paralelos 20º01´02ºº y 21º37´17" N y los meridianos 99º03´23" y 100º34´01" O del Meridiano de Greenwich.

  14. De culpable a perseguido: Baudelaire y el proceso de Las Flores del Mal

    Directory of Open Access Journals (Sweden)

    Juan Zapata

    2018-01-01

    Full Text Available ¿Cómo el poeta de Las Flores del Mal pasó de ser un escritor proscrito, y en consecuencia sospechoso, al autor perseguido e incomprendido que ha inmortalizado la historia literaria? ¿Cómo Baudelaire pudo desviar a su favor una circunstancia que, a primera  vista, era desafortunada? Baudelaire supo utilizar el escándalo que provocó la publicación de Las Flores del Mal para promover su figura pública. Un análisis de las posturas discursivas desplegadas por Baudelaire antes, durante y después del proceso nos permitirá comprender mejor la inversión que el poeta hace de su condenación, al transformar la sanción penal y moral, así como la exclusión a la que esta conduce, en un signo de su grandeza y de su gloria póstuma.

  15. Una especie nueva de Strombocactus (Cactaceae del río Moctezuma, Querétaro, México A new species of Strombocactus (Cactaceae from Moctezuma River, Querétaro, Mexico

    Directory of Open Access Journals (Sweden)

    Salvador Arias

    2010-12-01

    Full Text Available Se describe e ilustra Strombocactus corregidorae S. Arias et E. Sánchez, nueva especie del cañón del Infiernillo, en el río Moctezuma, en los límites del estado de Querétaro con Hidalgo. Difiere de S. disciformis por presentar cuerpos más prominentes, con espinas de mayor tamaño, rígidas, gruesas, persistentes y de color negro grisáceo, flores amarillas, así como semillas con células de paredes periclinales planas, microrrelieve finamente reticulado y la región hilo-micropilar no está cubierta por un estrofíolo. Se incluye una clave taxonómica para la identificación de las especies de Strombocactus , con base en caracteres del tallo, flor y la semilla.Strombocactus corregidorae S. Arias et E. Sanchez, from the Infiernillo Canyon, in the Moctezuma River, at the border between the Mexican states of Querétaro and Hidalgo, is described and illustrated. It differs from S. disciformis by its massive body, larger, strong, thick, persistent, black-gray spines, yellow flower, seeds with flat periclinal wall cells, finely reticulate micro-relief, and hilum-micropylar region not covered by a strophiole. An identification key to Strombocactus species, based on stem, flower, and seed characters is included.

  16. Genomic characterization and linkage mapping of the apple allergen genes Mal d 2 (thaumatin-like protein) and Mal d 4 (profilin)

    NARCIS (Netherlands)

    Gao, Z.S.; Weg, van de W.E.; Schaart, J.G.; Arkel, van G.; Breiteneder, H.; Hoffmann-Sommergruber, K.; Gilissen, L.J.W.J.

    2005-01-01

    Four classes of apple allergens (Mal d 1, ¿2, ¿3 and ¿4) have been reported. By using PCR cloning and sequencing approaches, we obtained genomic sequences of Mal d 2 (thaumatin-like protein) and Mal d 4 (profilin) from the cvs Prima and Fiesta, the two parents of a European reference mapping

  17. AKSESIBILITAS HOTEL HORISON BEKASI DENGAN MAL METROPOLITAN

    Directory of Open Access Journals (Sweden)

    Nadia Nursintia

    2016-03-01

    Full Text Available Abstract - Development of accommodation services is growing very fast, the construction of hotels ranging from low to star property confirms that the business is very profitable and promising. Growing hotel development as the presence and development of tourism in a region. Concept of mix used and are now growing in demand by developers. In addition to shorten the land, its facilities are increasingly in demand, because the concept of developing the land into two business buildings comprising the hotel and mall, can provide ease of access for service users to carry out all the activities that support their activities. Accessibility is a very important thing to be considered for the service users to choose the hotel accommodation that will be flown them. Distance, transportation, facilities, road conditions, and ease of location had been the benchmark and consideration to get a suitable hotel for their activities.   Keyword : Accessibility, Hotel   Abstrak - Perkembangan jasa akomodasi saat ini berkembang sangat cepat, dibangunnya hotel mulai dari hotel rendah hingga bintang menegaskan bahwa bisnis properti ini sangat menguntungkan dan menjanjikan. Pembangunan hotel berkembang seiring hadirnya dan berkembangnya pariwisata di suatu daerah. Konsep mix used pun kini semakin berkembang dan diminati oleh para pengembang. Selain karena mempersingkat lahan, fasilitas nya pun semakin diminati, karena konsep mengembangkan satu lahan menjadi dua bangunan usaha yang terdiri dari hotel dan mal, dapat memberikan kemudahan akses untuk para pengguna jasa untuk melakukan segala aktifitas yang mendukung kegiatannya. Aksesbilitas merupakan hal yang sangat penting yang menjadi pertimbangan bagi para pengguna jasa akomodasi untuk memilih hotel yang akan mereka singgahi. Jarak, transportasi, fasilitas, kondisi jalan, dan kemudahan lokasi lah yang menjadi tolak ukur dan pertimbangan untuk mendapatkan hotel yang cocok bagi kegiatan mereka.   Kata Kunci

  18. La evolución de la industria de autopartes en Querétaro, 1993-2008

    Directory of Open Access Journals (Sweden)

    Selva L. Daville-Landero

    2012-01-01

    Full Text Available A partir de los años noventa, y específicamente desde 1994 con la firma del Tratado de Libre Comercio de América del Norte (tlcan, se intensificó la política de reorientación de la economía mexicana hacia el exterior. En este artículo se analizan los cambios ocurridos en la industria de autopartes establecida en el estado de Querétaro con base en la información censal y la recabada mediante una encuesta. Una de las principales conclusiones de este estudio es el reforzamiento de la concentración de la actividad industrial y de la rama de autopartes en la Zona Metropolitana de Querétaro. También se pudo observar un mayor predominio de las filiales de las trasnacionales, que ha traído como consecuencia, prácticamente, la desaparición de encadenamientos productivos locales.

  19. Mal de meleda with congenital cataract: A novel case report

    Directory of Open Access Journals (Sweden)

    Anisha Sethi

    2015-01-01

    Full Text Available Mal de meleda (MdM, a rare autosomal recessive genodermatosis is characterized by erythema and hyperkeratosis of the palms and soles with a sharp demarcation and that progress with age (progrediens and extend to the dorsal aspects of the hands and feet (transgrediens. It has been associated with various conditions albeit rarely with congenial cataract. Ocular lens and the skin have the same embryological origins. We hereby present this novel case report of Mal de meleda in association with congenital posterior subcapsular cataract which to the best of our knowledge has not been reported from India before.

  20. O puru-puru da Amazônia (Pinta, Carate, Mal del Pinto etc

    Directory of Open Access Journals (Sweden)

    F. Nery Guimarães

    1948-03-01

    Full Text Available 1 "Purú-purú" é uma palavra indígena que quer dizer "pintado" ou "manchado", peculiar à Amazonia Brasileira. Com êsse nome é designada uma dermatose referida entre os selvicolas desde 1774, por Ribeiro Sampaio. Certas tribus, com alta incidência da moléstia passaram a ser cahamadas também "Purú-purús", o mesmo acontecendo com o rio onde habitavam - Rio Purús. 2 A doença existe na bacia do Rio Solimões e seus principais afluentes: Javari, Juruá, Purús, Içá, Japurá, e Negro. Por esses rios, o fóco da dermatose se continua nos países limitrofes com o Brasil: Guianas, Venezuela, Colombia, Perú (Equador e Bolivia. 3 Desde 1890 essa dermatose foi relacionada à pinta (carate ou mal del pinto por P. S. de Magalhães, idéa essa depois defendida por Juliano Moreira, Carlos Chagas, Roquete Pinto, Wappeus, O. da Fonseca Filho, Da Matta, Brumpt e outros, baseados na semelhança clínica e na terapêutica. Recentemente (1945, essa provavel identidade das duas dermatoses, recebeu fundamento sorológico de Biocca (que verificou a positividade das reações de Kline e Kahn em doentes de purú-purú, e, pelo presente trabalho, recebe base clínico-epidemio-anatomo-patológica. 4 Sob o ponto de vista clínico, as lesões cutaneas discromicas da moléstia, são de 3 órdens: a lesões papulo-eritemato-escamosas, isoladas ou não, arredondadas, pruriginosas e de bordos nitidos; b lesões maculo-escamosas, maiores mais pálidas, ás vezes já mostrando alterações pigmentares na parte central; c máculas discromod´rmicas, lisas ou ligeiramente escamosas, com maior ou menor alteração pigmentar, as quais assumem diferentes aspéctos, consequentes à hipo - ou hiperpigmentação, variaveis também com a côr do paciente. As colorações predominantes nas manchas, são o branco, o preto e o vermelho, com tonalidades eminentemente variaveis. Embora raramente, nessas extensas dermodiscromias, observa-se superposição de lesões papulo

  1. Frecuencia y distribución de algunos elementos del clima del estado de Querétaro

    Directory of Open Access Journals (Sweden)

    Consuelo Soto Mora

    1970-01-01

    Full Text Available En el presente trabajo se analiza la frecuencia de algunos fenómenos meteorológicos en el Estado de Querétaro tales como las lluvias, los nublados, las heladas y las tormentas eléctricas. También se examina la distribución de la intensidad de la lluvia. Finalmente se presentan mapas de distribución de las temperaturas máximas y mínimas para cuatro meses representativos de las variaciones térmicas. Los datos utilizados se presentan en forma tabular al final del trabajo los cuales se extrajeron de los archivos del Servicio Meteorológico Nacional y corresponden, en general, al periodo de 1911 a 1965.

  2. Evolution of mal ABC transporter operons in the Thermococcales and Thermotogales

    Directory of Open Access Journals (Sweden)

    Gogarten J Peter

    2008-01-01

    Full Text Available Abstract Background The mal genes that encode maltose transporters have undergone extensive lateral transfer among ancestors of the archaea Thermococcus litoralis and Pyrococcus furiosus. Bacterial hyperthermophiles of the order Thermotogales live among these archaea and so may have shared in these transfers. The genome sequence of Thermotoga maritima bears evidence of extensive acquisition of archaeal genes, so its ancestors clearly had the capacity to do so. We examined deep phylogenetic relationships among the mal genes of these hyperthermophiles and their close relatives to look for evidence of shared ancestry. Results We demonstrate that the two maltose ATP binding cassette (ABC transporter operons now found in Tc. litoralis and P. furiosus (termed mal and mdx genes, respectively are not closely related to one another. The Tc. litoralis and P. furiosus mal genes are most closely related to bacterial mal genes while their respective mdx genes are archaeal. The genes of the two mal operons in Tt. maritima are not related to genes in either of these archaeal operons. They are highly similar to one another and belong to a phylogenetic lineage that includes mal genes from the enteric bacteria. A unique domain of the enteric MalF membrane spanning proteins found also in these Thermotogales MalF homologs supports their relatively close relationship with these enteric proteins. Analyses of genome sequence data from other Thermotogales species, Fervidobacterium nodosum, Thermosipho melanesiensis, Thermotoga petrophila, Thermotoga lettingae, and Thermotoga neapolitana, revealed a third apparent mal operon, absent from the published genome sequence of Tt. maritima strain MSB8. This third operon, mal3, is more closely related to the Thermococcales' bacteria-derived mal genes than are mal1 and mal2. F. nodosum, Ts. melanesiensis, and Tt. lettingae have only one of the mal1-mal2 paralogs. The mal2 operon from an unknown species of Thermotoga appears to

  3. A zase ta malá povodí...

    Czech Academy of Sciences Publication Activity Database

    Tesař, Miroslav

    2017-01-01

    Roč. 67, č. 8 (2017), s. 33-38 ISSN 1211-0760. [Hydrologie malého povodí 2017. Praha, 18.04.2017-20.04.2017] Institutional support: RVO:67985874 Keywords : small basin * experimental hydrology * water balance * conference * watershed * hydrology * watershed Subject RIV: DA - Hydrology ; Limnology OBOR OECD: Hydrology

  4. Avaliação de genótipos tetraploides de bananeira cultivados em área infestada pelo agente causal do mal-do-Panamá

    Directory of Open Access Journals (Sweden)

    Sebastião de Oliveira e Silva

    2011-03-01

    Full Text Available O mal-do-Panamá é uma doença que causa grandes prejuízos à bananicultura no Brasil, uma vez que as principais cultivares em uso são suscetíveis ao Fusarium. Este trabalho teve como objetivos avaliar características agronômicas e resistência ao mal-do-Panamá de híbridos tetraploides de bananeira. O experimento foi conduzido no campo experimental da Embrapa Mandioca e Fruticultura Tropical, em delineamento casualizado, com 14 tratamentos e 10 repetições, nos anos de 2000 e 2001. Foram avaliados 14 tetraploides (FHIA-03, PV03-44, PC42-01, PV42-53, PV42-68, PV42-81, PV42-85, PV42-129, PV42-142, PV42-143, SH3640, ST12-31, ST42-08 e YB42-21 e a cultivar Maçã, usada como testemunha. Avaliaram-se as características altura da planta (m e diâmetro do pseudocaule (cm a 30 cm do solo, peso da massa do cacho (kg, penca (kg e fruto (g, número de pencas por cacho, de frutos por penca e de dias do florescimento à colheita, e a incidência do mal-do-Panamá. As médias dos genótipos foram agrupadas pelo teste de Scott e Knott, a 5% de probabilidade. Observa-se uma ampla variação genética nos caracteres avaliados. Os genótipos FHIA 03, ST12-31, SH3640, PV42-142, PV42-53 e PV42-68apresentam boas características agronômicas e resistência ao mal-do-Panamá.

  5. Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration.

    Science.gov (United States)

    Somogyi, Kálmán; Rørth, Pernille

    2004-07-01

    Cells migrating through a tissue exert force via their cytoskeleton and are themselves subject to tension, but the effects of physical forces on cell behavior in vivo are poorly understood. Border cell migration during Drosophila oogenesis is a useful model for invasive cell movement. We report that this migration requires the activity of the transcriptional factor serum response factor (SRF) and its cofactor MAL-D and present evidence that nuclear accumulation of MAL-D is induced by cell stretching. Border cells that cannot migrate lack nuclear MAL-D but can accumulate it if they are pulled by other migrating cells. Like mammalian MAL, MAL-D also responds to activated Diaphanous, which affects actin dynamics. MAL-D/SRF activity is required to build a robust actin cytoskeleton in the migrating cells; mutant cells break apart when initiating migration. Thus, tension-induced MAL-D activity may provide a feedback mechanism for enhancing cytoskeletal strength during invasive migration.

  6. [Opportunity cost for men who visit family medicine units in the city of Querétaro, Mexico].

    Science.gov (United States)

    Martínez Carranza, Edith Olimpia; Villarreal Ríos, Enrique; Vargas Daza, Emma Rosa; Galicia Rodríguez, Liliana; Martínez González, Lidia

    2010-12-01

    To determine the opportunity cost for men who seek care in the family medicine units (FMU) of the Mexican Social Security Institute (IMSS, Instituto Mexicano del Seguro Social) in the city of Querétaro. A sample was selected of 807 men, ages 20 to 59 years, who sought care through the family medicine, laboratory, and pharmacy services provided by the FMU at the IMSS in Querétaro. Patients referred for emergency services and those who left the facilities without receiving care were excluded. The sample (n = 807) was calculated using the averages for an infinite population formula, with a confidence interval of 95% (CI95%) and an average opportunity cost of US$5.5 for family medicine, US$3.1 for laboratory services, and US$2.3 for pharmacy services. Estimates included the amount of time spent on travel, waiting, and receiving care; the number of people accompanying the patient, and the cost per minute of paid and unpaid job activities. The opportunity cost was calculated using the estimated cost per minute for travel, waiting, and receiving care for patients and their companions. The opportunity cost for the patient travel was estimated at US$0.97 (CI95%: 0.81-1.15), while wait time was US$5.03 (CI95%: 4.08-6.09) for family medicine, US$0.06 (CI95%: 0.05-0.08) for pharmacy services, and US$1.89 (CI95%: 1.56-2.25) for laboratory services. The average opportunity cost for an unaccompanied patient visit varied between US$1.10 for pharmacy services alone and US$8.64 for family medicine, pharmacy, and laboratory services. The weighted opportunity cost for family medicine was US$6.24. Given that the opportunity cost for men who seek services in FMU corresponds to more than half of a minimum salary, it should be examined from an institutional perspective whether this is the best alternative for care.

  7. Modelling of innovative SANEX process mal-operations

    International Nuclear Information System (INIS)

    McLachlan, F.; Taylor, R.; Whittaker, D.; Woodhead, D.; Geist, A.

    2016-01-01

    The innovative (i-) SANEX process for the separation of minor actinides from PUREX highly active raffinate is expected to employ a solvent phase comprising 0.2 M TODGA with 5 v/v% 1-octanol in an inert diluent. An initial extract / scrub section would be used to extract trivalent actinides and lanthanides from the feed whilst leaving other fission products in the aqueous phase, before the loaded solvent is contacted with a low acidity aqueous phase containing a sulphonated bis-triazinyl pyridine ligand (BTP) to effect a selective strip of the actinides, so yielding separate actinide (An) and lanthanide (Ln) product streams. This process has been demonstrated in lab scale trials at Juelich (FZJ). The SACSESS (Safety of Actinide Separation processes) project is focused on the evaluation and improvement of the safety of such future systems. A key element of this is the development of an understanding of the response of a process to upsets (mal-operations). It is only practical to study a small subset of possible mal-operations experimentally and consideration of the majority of mal-operations entails the use of a validated dynamic model of the process. Distribution algorithms for HNO_3, Am, Cm and the lanthanides have been developed and incorporated into a dynamic flowsheet model that has, so far, been configured to correspond to the extract-scrub section of the i-SANEX flowsheet trial undertaken at FZJ in 2013. Comparison is made between the steady state model results and experimental results. Results from modelling of low acidity and high temperature mal-operations are presented. (authors)

  8. Abuso de drogas e transtornos alimentares entre mulheres: sintomas de um mal-estar de gênero?

    Directory of Open Access Journals (Sweden)

    Regina Helena Simões-Barbosa

    Full Text Available Resumo: O artigo discute o abuso de drogas e os transtornos alimentares sob as perspectivas críticas de gênero e do cuidado em saúde. Postula-se que o sofrimento subjetivo pode se expressar no corpo por meio das doenças psicossomáticas. Nessa perspectiva, a insaciável fome consumista das drogas ou de bens supérfluos, bem como o adoecimento pela fome voluntária em busca de um ideal de esbeltez, como na anorexia e bulimia, podem ser sintomas que denunciam o sofrimento feminino. Uma revisão nos campos da saúde coletiva e das teorias feministas destaca a magnitude dos fenômenos da medicalização e mercantilização da saúde presentes na psiquiatrização do mal-estar feminino. Na transição de gênero das sociedades capitalistas, as cobranças sociais pelo desempenho dos velhos e novos papéis femininos acentuam sentimentos de inadequação, traduzidos no mal-estar de gênero que circunda o abuso de drogas e os transtornos alimentares, analisados como patologias de protesto. Propõe-se o resgate do ideário do Programa de Assistência Integral à Saúde da Mulher, orientado pela integralidade, para enfrentar tais desafios.

  9. Fitossociologia de uma área de floresta estacional perenifólia na fazenda Amoreiras, Querência, MT Seasonal perennial forest site phytossociology in the amareiras farm, Querência, Mato Grosso state, Brazil

    Directory of Open Access Journals (Sweden)

    Sustanis Horn Kunz

    2010-08-01

    Full Text Available As florestas do sul da Amazônia, onde se encontra a Floresta Estacional Perenifólia, têm grande influência sobre a manutenção do equilíbrio físico regional e são as que mais estão ameaçadas pela ação antrópica, além de serem pouco conhecidas em relação à sua estrutura. Diante disso, objetivou-se estudar a estrutura fitossociológica de um trecho de Floresta Estacional Perenifólia na Bacia do Rio das Pacas em Querência, MT. A amostragem da vegetação consistiu na distribuição de 200 pontos quadrantes, sendo amostrados os indivíduos com diâmetro à altura de 1,30 m do solo (DAP ? 10 cm. A densidade total da área amostrada foi de 736 ind./ha, distribuídos em 58 espécies, 45 gêneros e 31 famílias. As espécies de maior Valor de Importância (VI, Ocotea leucoxylon (Sw. Laness., Trattinickia glaziovii Swart, Ouratea discophora Ducke, Xylopia amazonica R.E. Fr. e Myrcia multiflora (Lam. DC. corresponderam a 28,45% do VI total e também ocorreram em outros trechos de Floresta Estacional Perenifólia em Gaúcha do Norte, MT, porém não com a mesma representatividade. O índice de Shannon (3,51 pode ser considerado baixo por se tratar de Floresta Amazônica, mas a equabilidade de Pielou (0,86 evidenciou que a comunidade arbórea apresentava alta heterogeneidade florística.The Southern Amazon forests, where the Seasonal Perennial Forest occurs, has great influence on the maintenance of the regional physical equilibrium and they are among forests most threatened by anthropic action and are little known in relation to their structure. In this context, the objective of this work was to study phytosociological structure of a Seasonal Perennial Forest area in the Rio das Pacas Basin at Querência, state of Mato Grosso, Brazil. The vegetation sampling was composed of the distribution of 200 center quarter points, all individuals with DAP (diameter to height breast equal or superior to 10 cm were considered. The total density of

  10. La seducción del mal: crimen, arte, dictadura y poesía en "Estrella distante"

    OpenAIRE

    Díaz de la Cruz, Elena

    2017-01-01

    Trabajo de fin de Grado. Grado en Filología Hispánica. Curso académico 2016-2017 [ES]En la presente investigación se trabajará en torno al mal y su seducción a través del arte contemporáneo, la dictadura, el crimen, y todo ello envuelto en la poesía como forma de llevar a cabo la finalidad más antipoética que nos pudiéramos imaginar. El espacio “entre”, lo indefinido y el abismo va a ser el terreno donde la poesía cobra vida pero, además, crea un aura de diferentes posibilidades en torno a...

  11. Maltose-binding protein effectively stabilizes the partially closed conformation of the ATP-binding cassette transporter MalFGK2

    KAUST Repository

    Weng, Jingwei; Gu, Shuo; Gao, Xin; Huang, Xuhui; Wang, Wenning

    2017-01-01

    Maltose transporter MalFGK2 is a type-I importer in the ATP-binding cassette (ABC) transporter superfamily. Upon the binding of its periplasmic binding protein, MalE, the ATPase activity of MalFGK2 can be greatly enhanced. Crystal structures of the MalFGK2-MalE-maltose complex in a so-called

  12. Maltose-binding protein effectively stabilizes the partially closed conformation of the ATP-binding cassette transporter MalFGK2

    KAUST Repository

    Weng, Jingwei

    2017-02-23

    Maltose transporter MalFGK2 is a type-I importer in the ATP-binding cassette (ABC) transporter superfamily. Upon the binding of its periplasmic binding protein, MalE, the ATPase activity of MalFGK2 can be greatly enhanced. Crystal structures of the MalFGK2-MalE-maltose complex in a so-called

  13. Mucin 1 (MUC1 is a novel partner for MAL2 in breast carcinoma cells

    Directory of Open Access Journals (Sweden)

    McGuckin Michael A

    2009-01-01

    Full Text Available Abstract Background The MAL2 gene, encoding a four-transmembrane protein of the MAL family, is amplified and overexpressed in breast and other cancers, yet the significance of this is unknown. MAL-like proteins have trafficking functions, but their molecular roles are largely obscure, partly due to a lack of known binding partners. Methods Yeast two-hybrid screening of a breast carcinoma cDNA expression library was performed using a full-length MAL2 bait, and subsequent deletion mapping experiments were performed. MAL2 interactions were confirmed by co-immunoprecipitation analyses and confocal microscopy was employed to compare protein sub-cellular distributions. Sucrose density gradient centrifugation of membranes extracted in cold Triton X-100 was employed to compare protein distributions between Triton X-100-soluble and -insoluble fractions. Results The tumor-associated protein mucin 1 (MUC1 was identified as a potential MAL2 partner, with MAL2/MUC1 interactions being confirmed in myc-tagged MAL2-expressing MCF-10A cells using co-immunoprecipitation assays. Deletion mapping experiments demonstrated a requirement for the first MAL2 transmembrane domain for MUC1 binding, whereas the MAL2 N-terminal domain was required to bind D52-like proteins. Confocal microscopy identified cytoplasmic co-localisation of MUC1 and MAL2 in breast cell lines, and centrifugation of cell lysates to equilibrium in sucrose density gradients demonstrated that MAL2 and MUC1 proteins were co-distributed between Triton X-100-soluble and -insoluble fractions. However co-immunoprecipitation analyses detected MAL2/MUC1 interactions in Triton X-100-soluble fractions only. Myc-MAL2 expression in MCF-10A cells was associated with both increased MUC1 detection within Triton X-100-soluble and -insoluble fractions, and increased MUC1 detection at the cell surface. Conclusion These results identify MUC1 as a novel MAL2 partner, and suggest a role for MAL2 in regulating MUC1

  14. Sequential Action of MalE and Maltose Allows Coupling ATP Hydrolysis to Translocation in the MalFGK2 Transporter.

    Science.gov (United States)

    Bao, Huan; Dalal, Kush; Cytrynbaum, Eric; Duong, Franck

    2015-10-16

    ATP-binding cassette (ABC) transporters have evolved an ATP-dependent alternating-access mechanism to transport substrates across membranes. Despite important progress, especially in their structural analysis, it is still unknown how the substrate stimulates ATP hydrolysis, the hallmark of ABC transporters. In this study, we measure the ATP turnover cycle of MalFGK2 in steady and pre-steady state conditions. We show that (i) the basal ATPase activity of MalFGK2 is very low because the cleavage of ATP is rate-limiting, (ii) the binding of open-state MalE to the transporter induces ATP cleavage but leaves release of Pi limiting, and (iii) the additional presence of maltose stimulates release of Pi, and therefore increases the overall ATP turnover cycle. We conclude that open-state MalE stabilizes MalFGK2 in the outward-facing conformation until maltose triggers return to the inward-facing state for substrate and Pi release. This concerted action explains why ATPase activity of MalFGK2 depends on maltose, and why MalE is essential for transport. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  15. Historia de la voluntad y banalidad del mal

    Directory of Open Access Journals (Sweden)

    Prior Olmos, Ángel

    2010-04-01

    Full Text Available This article discusses the connections existing in The Life of the Mind between the theory of the banality of evil and the history of the will. It interprets Eichmann in Jerusalem as a work about bureaucratic evil, but above all as research concerning both moral and juridical responsibility. From the history of the will it highlights three different aspects that can be connected with the problem of responsibility: the ontology of contingency, the idea of individuality linked to the will and the capacity of transcendence and resistance that we see in the Duns Scotus’ theory, where liberty equals indifference. Finally, it suggests a link between the banality of evil and the ontology of good as these are present in “Some questions of moral philosophy” (1965-1966, the fight against Gnosticism and the defense of a relationship between morality and evil’s intelligibility.

    El artículo plantea las conexiones entre la tesis de la banalidad del mal y la historia de la voluntad presente en La vida del espíritu. Interpreta Eichmann en Jerusalén como una obra sobre el mal burocrático, pero sobre todo como estudio acerca de la responsabilidad, tanto jurídica como moral. De la historia de la voluntad resalta tres aspectos que pueden ser puestos en conexión con el problema de la responsabilidad: la ontología de la contingencia, la idea de individualidad vinculada a la voluntad y la capacidad de trascendencia y resistencia subyacentes en la teoría de Duns Escoto de la libertad como indiferencia. Por último, sugiere una vinculación entre la banalidad del mal y la ontología del bien desarrolladas en “Algunas cuestiones de filosofía moral”, de 1965-1966, la lucha contra el gnosticismo y la defensa de una relación entre moralidad e inteligibilidad del mal.

  16. O Enigma do Mal: uma leitura do 'De casu diaboli'de Santo Anselmo (The enigma of evil: a reading of St. Anselm’s De casu diaboli - DOI: 10.5752/P.2175-5841.2013v11n32p1551

    Directory of Open Access Journals (Sweden)

    Manoel Luís Cardoso Vasconcellos

    2013-12-01

    Full Text Available O presente artigo quer investigar o problema do mal na perspectiva de Santo Anselmo, tomando como ponto de partida sua obra De casu diaboli, onde o tema é abordado, a partir da íntima ligação entre mal e pecado. Ao enfocar o mal na perspectiva da queda diabólica, o Doutor Magnífico intenta mostrar a conexão entre vontade, liberdade e justiça. Sua preocupação é investigar o significado moral da má escolha, realizada por uma criatura racional e puramente espiritual, feita boa e para ser boa. O pecado, consoante o autor, não está em almejar a felicidade, pois tal desejo é dádiva divina; o mal praticado pelo anjo está, precisamente, em querer a felicidade fora da justiça, isto é, ao querer ser feliz, ele foi de encontro ao que ele deveria ser: quis ser semelhante a Deus, extrapolando a sua própria natureza, pois ele desejou algo que, enquanto criatura, não caberia a ele almejar. Este é o ponto de partida para analisar o mal e sua mais dramática consequência, o sofrimento. Palavras-chave: Mal. Vontade. Justiça. Anselmo.   Abstract This article aims to investigate the problem of evil in Saint Anselm, especially in his treatise De casu diaboli. He approaches this issue from the close connection between evil and sin. Upon analyzing evil from the diabolic fall perspective, Dr. Magnificent tries to establish a connection between will, freedom and justice. This text investigates the moral meaning of misconduct, carried out by a rational and purely spiritual creature that was created good and meant to be good. Seeking for happiness is not itself a sin, according to the author, for such a wish is a gift from God. The evil done by the angel lies in the act of wanting happiness without justice, that is, on wanting to be happy, the angel contradicted what he was supposed to be: he wanted to be like God, transcending his own nature, as he wished for something that, as a creature, he was not fit to wish for. This is the starting point to

  17. Tu nos aposte protege

    DEFF Research Database (Denmark)

    Frederiksen, Britta Olrik

    2007-01-01

    Aspirationen af p, t og k i dansk er stedmoderligt behandlet af den gren af den historiske sprogforskning der bygger på skriftligt kildemateriale. Skrivemåden tu nos aposte protege for tu nos ab hoste protege 'bekyt du os mod fjenden' i en tilskrift fra anden halvdel af 1300-tallet i...

  18. Glucose and maltose metabolism in MIG1-disrupted and MAL-constitutive strains of Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Klein, Christopher; Olsson, Lisbeth; Rønnow, B

    1997-01-01

    in a mixed glucose-maltose medium revealed that the MAL-constitutive strains were more alleviated than the single MIG1-disrupted transformant. While all transformants exhibited higher maximum specific growth rates (0.24-0.25 h(-1)) in glucose-maltose mixtures than the wild type strain (0.20 h(-1)), the MAL-constitutive...

  19. Characterization of different crystal forms of the alpha-glucosidase MalA from Sulfolobus solfataricus

    DEFF Research Database (Denmark)

    Ernst, Heidi Asschenfeldt; Willemoës, Martin; Lo Leggio, Leila

    2005-01-01

    MalA is an alpha-glucosidase from the hyperthermophilic archaeon Sulfolobus solfataricus. It belongs to glycoside hydrolase family 31, which includes several medically interesting alpha-glucosidases. MalA and its selenomethionine derivative have been overproduced in Escherichia coli...

  20. Effect of postharvest storage on the expression of the apple allergen Mal d 1

    NARCIS (Netherlands)

    Sancho, Ana I.; Foxall, Robert; Browne, Tom; dey, Rickmer; Zuidmeer, Laurian; Marzban, Gorji; Waldron, Keith W.; van Ree, Ronald; Hoffmann-Sommergruber, Karin; Laimer, Margit; Mills, E. N. Clare

    2006-01-01

    Consumption of fresh apples can cause allergy in susceptible individuals. A competitive enzyme-linked immunosorbent assay (ELISA) has been developed to determine Mal d 1 levels in apple pulp using a monoclonal antibody (BIP-1). The ELISA was able to rank ten cultivars according to their Mal d 1

  1. Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma

    Directory of Open Access Journals (Sweden)

    Zhang Jun

    2010-11-01

    Full Text Available Abstract Background To identify new and useful candidate biomarkers in head and neck squamous cell carcinoma (HNSCC, we performed a genome-wide survey and found that Myelin and lymphocyte-associated protein (MAL was a gene that was markedly down-regulated in HNSCC. Hence, we investigated the mechanism of MAL silencing and the effects of MAL on the proliferation, invasion, and apoptotic potential in HNSCC. Results MAL was significantly down-regulated in 91.7% of HNSCC specimens at the mRNA level as compared with adjacent normal tissues (P = 0.0004. Moreover, the relative transcript levels of the MAL gene were remarkably decreased by five-fold in nine HNSCC cell lines as compared with normal head and neck epithelium cells. MAL gene expression was restored in 44%, 67%, and 89% in HNSCC cell lines treated with TSA, 5-Aza-dC, and TSA plus 5-Aza-dC, respectively. Furthermore, bisulfate-treated DNA sequencing demonstrated that the two CpG islands (that is, M1 and M2 located in MAL promoter region were completely methylated in the HNSCC cell lines (CpG methylated ratio was more than 90%, and only one CpG island (that is, M1 was partially methylated in HNSCC tissues (CpG methylated ratio between 20% and 90%. A significant reduction in cell proliferation and a change in the cell cycle profile were also observed in MAL transfectants. Matrigel assay demonstrated that the invasiveness of HNSCC cells significantly decreased. A significant increase in the population of apoptotic cells was observed in MAL transfected cells. The exogenous expression of the MAL gene suppressed malignant phenotypes, while the cell death induced by MAL gene transfer was a result of apoptosis as demonstrated by the induction of cleavage of the poly (that is, ADP-ribose polymerase. Additionally, tumor growth was suppressed in cells expressing MAL as compared with cells not expressing MAL. Conclusion Our data suggest that the epigenetic inactivation of MAL, as a candidate tumor

  2. Fernandez osteotomy of radio distal with mal united fracture

    International Nuclear Information System (INIS)

    Garcia Herrera, Alvaro; Bocanegra, Sergio; Suarez, Fabio

    2003-01-01

    We review prospectively our experience in the military hospital in Bogota, Colombia, with the opening-wedge osteotomy for the treatment of a mal united fracture of the distal end of the radius in fifty-six consecutive patients from 1990 to 2002. The indications for operation were pain predominantly in the radio-ulnar joint and functional limitation with grip strength loss. Preoperative radiographs revealed an average ulnar inclination of 14 degrees, an average ulnar variance of four millimeters, and increased dorsal tilt (colles deformity) that averaged 28 degrees. All patients had limited function. The average grip strength was a force of fifteen kilograms compared with a force of thirty-one kilograms in the contralateral hand. Postoperatively, all of the patients had substantial improvement in function, relief of pain and grip strength increased. The functional results were rated as very good in eleven patients, good in thirty-six, fair in nine

  3. [Clonage of the "malA" region of "Escherichia coli" K12: nucleotide sequence of the regulatory region and the promoters, identification and purification of the MalT-activator protein (author's transl)].

    Science.gov (United States)

    Raibaud, O; Débarbouillé, M; Cossart, P

    1982-01-01

    A 5,800-bp (base pair) HindIII-EcoRI DNA fragment containing malT, the positive regulator gene of the maltose regulon, and most of malP, the structural gene for maltodextrin phosphorylase, was cloned into pBR322. A sequence of 802 bp was established in a DNA segment containing the promotor for malPQ and the promoter for malT. A total of 611 bp separates the initiation codons for these two genes, which are transcribed in opposite directions. The malT product was identified as a 94,000 dalton polypeptide.

  4. "Kevad uhkelt sammub mal kui jumalanna..." : [luuletused] / Ljubov Dergatshova ; tlk. Arvo Valton

    Index Scriptorium Estoniae

    Dergatshova, Ljubov

    2006-01-01

    Sisu: "Kevad uhkelt sammub mal kui jumalanna..." ; "Maga, pojake, maga mu päike..." ; "Mis kaunis õhtu! Lumi tahke..." ; "Raskel tunnil sirutab kes käe...". Luuletused paralleelselt ersa ja eesti keeles

  5. Comprometimento pulmonar na malária (revisão Pulmonary involvement in malaria

    Directory of Open Access Journals (Sweden)

    Marcos Boulos

    1993-02-01

    Full Text Available Com uma incidência de 3 a 10% dos casos e letalidade próxima a 70%, o comprometimento pulmonar constitui uma das manifestações mais graves da malária por Plasmodium falciparum. Embora sua patogênese não esteja perfeitamente esclarecida, reconhece-se que a hiperativação do sistema imune por antígenos liberados pelo Plasmodium falciparum desempenhe um importante papel no desencadeamento e agravamento das lesões. A estrutura alvo parece ser o endotélio capilar, responsável pelo fluxo de líquidos para o espaço intersticial. Essas células são ativadas por ação de citocinas, produzidas por linfócitos e macrófagos durante a resposta imune, e passam a expressar em sua membrana celular receptores e moléculas de aderência que facilitam a sequestração de eritrócitos parasitados e também a aderência de células capazes de produzir mediadores inflamatórios. A reação inflamatória e a lesão endotelial que se seguem, juntamente com as alterações hemodinâmicas induzidas pelo bloqueio capilar devido ao acúmulo local de eritrócitos e células inflamatórias causam alterações de permeabilidade vascular e, consequentemente, acúmulo de líquido nos espaços intersticiais e alvéolos. Nos casos mais graves, as manifestações clínicas assemelham-se às do quadro da Síndrome do desconforto respiratório do adulto. Comprometimento pulmonar grave pode se instalar rapidamente em qualquer estágio da evolução clínica da malária, mesmo após a cura parasitológica, desconhecendo-se os fatores desencadeantes. Hiperparasitismo, insuficiência renal e gravidez constituem fatores predisponentes. O prognóstico dependerá da rapidez com que o diagnóstico for estabelecido e o correto tratamento instituído. Além do tratamento instituído contra o parasita, especial atenção deverá ser dispensada à monitorização hemodinâmica, se possível através de cateter de Swan-Ganz, à manutenção de adequada oxigenação e balanço h

  6. BAYT AL-MAL AND ITS ROLE IN ECONOMIC DEVELOPMENT: A CONTEMPORARY STUDY

    Directory of Open Access Journals (Sweden)

    Md. Habibur RAHMAN

    2015-08-01

    Full Text Available Bayt al-Mal, known as the public treasury of Islamic state, was established by the Prophet-may peace be upon Him- and then it was further extended and expanded by Abu Bakr and Umar, who succeeded the Prophet as the Caliph of the Islamic state. It is the state treasury that keeps the sole authority to mobilize the funds of the state. This paper aims to study the potential role and contribution of Bayt al-Mal to economic development in the contemporary context. It will be a qualitative paper and the analytical and descriptive method will be applied. Historically Bayt al-Mal played a great role in the distribution and redistribution of funds. It performed the function that is similar to the function of the ministry of finance at present. It also carried out the jobs of central bank in terms of monitoring, issuing currencies, controlling credits and so forth. Through discussing its sources and expenditures the paper posits that the role of Bayt al-Mal can be revived and accelerated by, for example, providing small-medium funds, managing Zakah and awqaf, channeling the funds, issuing various financial instruments and so forth. Bayt al-Mal could have a significant role in the eradication of poverty from the state. The paper concludes that with the rapid growth of Islamic finance, the Bayt al-Mal can be utilized in parallel in order to have a robust economic development.

  7. Perspectivas del crecimiento urbano: la actividad comercial minorista y el transporte de bienes en la Zona Metropolitana de Querétaro (México

    Directory of Open Access Journals (Sweden)

    Eduardo Betanzo-Quezada

    2015-01-01

    Full Text Available Se muestran las perspectivas del crecimiento urbano, la actividad comercial minorista y su relación transversal con el transporte de bienes en la Zona Metropolitana de Querétaro (México. Con una metodología de análisis de información estadística de tipo agregado, se examinan esos determinantes con el objetivo de revelar sus tendencias en la ciudad. El paralelismo encontrado en las tendencias de comportamiento de los determinantes examinados conduce a concluir que es cada vez más necesario conectar al transporte urbano de carga con la planeación económica y urbana, y ubicarlo dentro de las prioridades de las administraciones gubernamentales.

  8. De reglas blandas, árbitros mansos y malos partidos: las leyes y la autonomía del órgano electoral de Querétaro

    Directory of Open Access Journals (Sweden)

    Martha Gloria Morales Garza

    2012-01-01

    Full Text Available En el artículo se analiza la evolución de la normatividad electoral en el estado de Querétaro desde 1994 hasta las reformas que estaban en proceso legislativo en septiembre de 2011. Se analiza el impacto de las leyes en las prácticas políticas, pero también las acciones de los actores políticos, incluidos los ciudadanos, que modifican esas mismas reglas, en un ir y venir entre sujetos y estructuras. Se muestra cómo la aspiración autoritaria trasciende las siglas partidistas, al presentarse no cuando gobierna un partido u otro sino cuando los contrapesos institucionales y de opinión pública son débiles.

  9. Sobre el mal radical. Ensayo de la heterodoxia kantiana

    Directory of Open Access Journals (Sweden)

    Gómez Caffarena, José

    2004-06-01

    Full Text Available The kantian theory of a «radical evil inhabiting human nature» contrasts with a general anthropological optimistic tenor perceptible in kantian philosophy. It meant a significant turning point in the often too superficial optimistic trends of the Enlightenment. Hut its literal sense (appealing to an act of pre-individual freedom has an obvious difficulty. The present paper proposes an heterodox interpretation, which would avoid the difficulty, although so losing part of the tempting enigmatic reach of the kantian proposal.

    La teoría del «mal radical en la naturaleza humana», expuesta por Kant en La religión dentro de los límites de la mera razón, hace contraste con el optimismo antropológico que empapa el Criticismo. Constituyó, sin duda, una importante denuncia frente a la banalidad de muchos optimismos ilustrados. Pero su letra (acto de libertad pre-individual tiene una obvia dificultad. El artículo propone una reinterpretación que la evitaría, aunque desdramatizando un tanto el tentador alcance enigmático de la propuesta kantiana.

  10. A formação social do arquitecto: Crise nos cursos de arquitectura, 1968‑1969

    Directory of Open Access Journals (Sweden)

    Gonçalo Canto Moniz

    2012-10-01

    Full Text Available A regulamentação da reforma do ensino da arquitectura em 1957 inicia um processo de transformações sucessivas no quotidiano dos cursos de arquitectura que irá culminar com uma crise no ano de 1969.Ao longo de uma década de funcionamento, a nova orgânica proposta pela reforma não conseguiu, na sua globalidade, introduzir uma nova pedagogia nem democratizar o funcionamento das escolas, ficando refém do autoritarismo do Ministério da Educação. No entanto, a sua rigidez científica e administrativa estimulou professores e alunos a desenvolver estratégias, quer de projecto, quer de reflexão e debate, que procuraram promover a função social do arquitecto atento aos problemas da sociedade e da cidade, por oposição ao arquitecto tecnocrático.Nos anos de 1968 e 1969 as duas escolas, tal como a universidade e a sociedade, politizam o seu discurso. Os estudantes e os professores reivindicam abertamente alterações profundas na gestão da escola, nos métodos pedagógicos e nos objectivos do ensino, exigindo a reforma da Reforma de 57.Este texto aborda os momentos críticos deste processo de consciencialização política e social dos estudantes, que procura recolocar o papel da Escola no debate sobre a formação e sobre a profissão de arquitecto. No final de 1969 as escolas de arquitectura estão em crise, porque a universidade está em crise, mas também porque a profissão está crise.

  11. Assessment of allelic diversity in intron-containing Mal d 1 genes and their association to apple allergenicity

    Directory of Open Access Journals (Sweden)

    Bolhaar Suzanne THP

    2008-11-01

    Full Text Available Abstract Background Mal d 1 is a major apple allergen causing food allergic symptoms of the oral allergy syndrome (OAS in birch-pollen sensitised patients. The Mal d 1 gene family is known to have at least 7 intron-containing and 11 intronless members that have been mapped in clusters on three linkage groups. In this study, the allelic diversity of the seven intron-containing Mal d 1 genes was assessed among a set of apple cultivars by sequencing or indirectly through pedigree genotyping. Protein variant constitutions were subsequently compared with Skin Prick Test (SPT responses to study the association of deduced protein variants with allergenicity in a set of 14 cultivars. Results From the seven intron-containing Mal d 1 genes investigated, Mal d 1.01 and Mal d 1.02 were highly conserved, as nine out of ten cultivars coded for the same protein variant, while only one cultivar coded for a second variant. Mal d 1.04, Mal d 1.05 and Mal d 1.06 A, B and C were more variable, coding for three to six different protein variants. Comparison of Mal d 1 allelic composition between the high-allergenic cultivar Golden Delicious and the low-allergenic cultivars Santana and Priscilla, which are linked in pedigree, showed an association between the protein variants coded by the Mal d 1.04 and -1.06A genes (both located on linkage group 16 with allergenicity. This association was confirmed in 10 other cultivars. In addition, Mal d 1.06A allele dosage effects associated with the degree of allergenicity based on prick to prick testing. Conversely, no associations were observed for the protein variants coded by the Mal d 1.01 (on linkage group 13, -1.02, -1.06B, -1.06C genes (all on linkage group 16, nor by the Mal d 1.05 gene (on linkage group 6. Conclusion Protein variant compositions of Mal d 1.04 and -1.06A and, in case of Mal d 1.06A, allele doses are associated with the differences in allergenicity among fourteen apple cultivars. This information

  12. Sobre los saberes culturales y el fenómeno "sentirse bien-sentirse mal" On cultural knowledge and the phenomenon "feel good-fell bad"

    Directory of Open Access Journals (Sweden)

    Virtudes Rodero Sánchez

    2010-09-01

    Full Text Available El objetivo del presente estudio es identificar los saberes culturales inmersos en el fenómeno "sentirse-bien, sentirse mal", en diferentes situaciones de cuidado. Se elaboró un estudio cualitativo con un enfoque fenomenológico interpretativo, mediante el análisis de 18 narrativas a partir de entrevistas en profundidad realizadas por alumnas del Máster en Ciencias de la Enfermería en diferentes contextos de cuidados. Las categorías identificadas fueron: (1 Cronicidad y concepto de sentirse bien-sentirse mal. En la cronicidad este concepto está íntimamente relacionado con la recuperación de las actividades de la vida diaria y es componente importante en la percepción individual del concepto "calidad de vida". (2 Momentos agudos de enfermedad y concepto de sentirse bien-sentirse mal. En el análisis de los relatos del paciente aparecieron aspectos esenciales del fenómeno "sentirse bien-sentirse mal" para aumentar la comprensión de aspectos universales de algunos de sus componentes. Destacar que el fenómeno está íntimamente relacionado con la recuperación de las actividades de la vida diaria, y es un mediador importante en la percepción individual del concepto "calidad de vida". El interés de cara al cuidado es distinguir sus componentes universales, contextualizarlos en la práctica, dentro de las singularidades que presenta cada persona, de modo que nos permita su potenciación. El resultado es un cambio en la experiencia sentida.The object of the present study is to identify cultural knowledges immersed in the feeling-well, feeling-bad phenomenon in different care settings. A qualitative study was undertaken using a phenomenological interpretation approach through a meta-analysis of 18 narratives of profound interviews undertaken by Nursing Science Master Degree Students in different care situations. The categories established were: (1 Chronicity and the concept of feeling well-feeling bad. In this category, this concept is

  13. A brief history of typical absence seizures - Petit mal revisited.

    Science.gov (United States)

    Brigo, Francesco; Trinka, Eugen; Lattanzi, Simona; Bragazzi, Nicola Luigi; Nardone, Raffaele; Martini, Mariano

    2018-03-01

    In this article, we have traced back the history of typical absence seizures, from their initial clinical description to the more recent nosological position. The first description of absence seizures was made by Poupart in 1705 and Tissot in 1770. In 1824, Calmeil introduced the term "absences", and in 1838, Esquirol for the first time used the term petit mal. Reynolds instead used the term "epilepsia mitior" (milder epilepsy) and provided a comprehensive description of absence seizures (1861). In 1854, Delasiauve ranked absences as the seizure type with lower severity and introduced the concept of idiopathic epilepsy. Otto Binswanger (1899) discussed the role of cortex in the pathophysiology of "abortive seizures", whereas William Gowers (1901) emphasized the importance of a detailed clinical history to identify nonmotor seizures or very mild motor phenomena which otherwise may go unnoticed or considered not epileptic. At the beginning of the 20th Century, the term pyknolepsy was introduced, but initially was not universally considered as a type of epilepsy; it was definitely recognized as an epileptic entity only in 1945, based on electroencephalogram (EEG) recordings. Hans Berger, the inventor of the EEG, made also the first EEG recording of an atypical absence (his results were published only in 1933), whereas the characteristic EEG pattern was reported by neurophysiologists of the Harvard Medical School in 1935. The discovery of EEG made it also possible to differentiate absence seizures from so called "psychomotor" seizures occurring in temporal lobe epilepsy. Penfield and Jasper (1938) considered absences as expression of "centrencephalic epilepsy". Typical absences seizures are now classified by the International League Against Epilepsy among generalized nonmotor (absence) seizures. Copyright © 2018 Elsevier Inc. All rights reserved.

  14. Metabolic and functional connectivity changes in mal de debarquement syndrome.

    Directory of Open Access Journals (Sweden)

    Yoon-Hee Cha

    Full Text Available Individuals with mal de debarquement syndrome (MdDS experience a chronic illusion of self-motion triggered by prolonged exposure to passive motion, such as from sea or air travel. The experience is one of rocking dizziness similar to when the individual was originally on the motion trigger such as a boat or airplane. MdDS represents a prolonged version of a normal phenomenon familiar to most individuals but which persists for months or years in others. It represents a natural example of the neuroplasticity of motion adaptation. However, the localization of where that motion adaptation occurs is unknown. Our goal was to localize metabolic and functional connectivity changes associated with persistent MdDS.Twenty subjects with MdDS lasting a median duration of 17.5 months were compared to 20 normal controls with (18F FDG PET and resting state fMRI. Resting state metabolism and functional connectivity were calculated using age, grey matter volume, and mood and anxiety scores as nuisance covariates.MdDS subjects showed increased metabolism in the left entorhinal cortex and amygdala (z>3.3. Areas of relative hypometabolism included the left superior medial gyrus, left middle frontal gyrus, right amygdala, right insula, and clusters in the left superior, middle, and inferior temporal gyri. MdDS subjects showed increased connectivity between the entorhinal cortex/amygdala cluster and posterior visual and vestibular processing areas including middle temporal gyrus, motion sensitive area MT/V5, superior parietal lobule, and primary visual cortex, while showing decreased connectivity to multiple prefrontal areas.These data show an association between resting state metabolic activity and functional connectivity between the entorhinal cortex and amygdala in a human disorder of abnormal motion perception. We propose a model for how these biological substrates can allow a limited period of motion exposure to lead to chronic perceptions of self-motion.

  15. A democracia no Brasil não é um mal-entendido = Democracy in Brazil is not a misunderstanding

    Directory of Open Access Journals (Sweden)

    Coelho, Maria Francisca Pinheiro

    2014-01-01

    Full Text Available A ideia deste trabalho surgiu da famosa frase de Sérgio Buarque de Holanda, em Raízes do Brasil: “A democracia no Brasil foi sempre um lamentável mal-entendido. ” Para o autor, inspirado nos tipos ideais weberianos e sob um olhar comparativo, o Brasil com seu homem cordial – aquele que age mais pelo coração do que pela razão – e com o predomínio do espaço privado sobre o público não se apresentava como um solo receptivo aos valores de igualdade da democracia. O texto pretende sugerir que a institucionalização das regras do jogo democrático relativiza o peso da cultura, sem, contudo, alterar seus traços no ritmo compatível com as mudanças das normas. O Brasil, com todos os problemas decorrentes de uma sociedade desigual e hierárquica, situa-se atualmente entre as democracias mais consolidadas da América Latina, que mais interagem e que apresentam disposição para o diálogo

  16. Instrumentação anterior da coluna em espondilite tuberculosa mal de pott: Relato de caso

    Directory of Open Access Journals (Sweden)

    Farage Luciano

    2002-01-01

    Full Text Available Relatamos caso de tratamento cirúrgico com instrumentação anterior em espondilite tuberculosa (mal de Pott, em mulher de 71 anos, que se encontrava em tratamento para tuberculose na forma pulmonar e evoluiu com dor lombar, dificuldade progressiva para deambular, cifose e disfunção vesical. A ressonância magnética revelou lesão nos corpos vertebrais de T12 e L1 com abcesso paravertebral. A paciente foi tratada cirurgicamente por acesso tóraco-abdominal lateral. Os corpos vertebrais foram ressecados, foi instalado uma gaiola vertical (mesh cage e a coluna foi estabilizada com placa lateral (Z plate e parafusos fixados em T11 e L2. Essa técnica permite boa artrodese dos corpos vertebrais remanescentes e boa estabilidade da coluna, sem comprometer a eficácia dos tuberculostáticos. A paciente foi avaliada um ano após a operação e não apresentava déficit motor, dor residual e a cifose foi desfeita.

  17. Contribución al conocimiento de los malófagos (Phthiraptera, Amblycera, Ischnocera de aves peruanas. Parte 1

    Directory of Open Access Journals (Sweden)

    Luis A. Gomez-Puerta

    2015-12-01

    Full Text Available En el presente trabajo se reporta nueve especies de malófagos colectados de aves peruanas. Dos malófagos Amblycera: Heteromenopon laticapitis y Menacanthus pici, así como siete malófagos Ischnocera: Alcedoffula theresae, Brueelia brunneinucha, Chelopistes meleagridis, Columbicola columbae, Paragoniocotes aratingae, Penenirmus jungens y Saemundssonia (Saemundssonia lari, fueron determinados mediante el diagnóstico morfológico. Se realiza una breve descripción de cada malófago, así como la discusión de sus hospederos y distribución.

  18. Algoritmo para monitoramento da incidência da malária na Amazônia brasileira, 2003 a 2010

    Directory of Open Access Journals (Sweden)

    Rui Moreira Braz

    2014-03-01

    Full Text Available OBJETIVO: Avaliar um algoritmo para detecção da variação da incidência da malária nos municípios da Amazônia brasileira. MÉTODOS: Avaliou-se um sistema de monitoramento automatizado, baseado em um algoritmo desenvolvido anteriormente pelos autores. O algoritmo utiliza o diagrama de controle por quartis para classificação dos municípios em quatro grupos, conforme a variação da incidência da malária: grupo 1 (redução da incidência-aqueles com incidência abaixo dos valores esperados; grupo 2 (incidência esperada-aqueles com incidência dentro dos valores esperados; grupo 3 (epidemia-aqueles com incidência acima dos valores esperados; grupo 4 (caso esporádico-aqueles com apenas um caso durante o ano. O período de análise foi de 2003 a 2010. Foram estudados todos os municípios existentes nos nove estados que compõem a Amazônia brasileira (805 municípios em 2003 e 807 a partir de 2004. RESULTADOS: Com base nessa metodologia, os municípios da região foram assim classificados: grupo 1, 152 municípios (18,8% da região em 2003 e 109 (13,5% em 2010; grupo 2, 206 (25,6% em 2003 e 331 (41,0% em 2010; grupo 3, 391 (48,6% em 2003 e 308 (38,2% em 2010; e grupo 4, 56 (7,0% em 2003 e 59 (7,3% em 2010. CONCLUSÕES: O algoritmo possibilitou verificar que, na Amazônia brasileira, o número de municípios com epidemias de malária em 2010 diminuiu em relação a 2003, enquanto o número de municípios com incidência esperada aumentou. No mesmo período, houve pouca variação no número de municípios com redução da incidência e daqueles com casos esporádicos.

  19. Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG.

    Directory of Open Access Journals (Sweden)

    Raquel Bello-Morales

    Full Text Available The velocity of the nerve impulse conduction of vertebrates relies on the myelin sheath, an electrically insulating layer that surrounds axons in both the central and peripheral nervous systems, enabling saltatory conduction of the action potential. Oligodendrocytes are the myelin-producing glial cells in the central nervous system. A deeper understanding of the molecular basis of myelination and, specifically, of the transport of myelin proteins, will contribute to the search of the aetiology of many dysmyelinating and demyelinating diseases, including multiple sclerosis. Recent investigations suggest that proteolipid protein (PLP, the major myelin protein, could reach myelin sheath by an indirect transport pathway, that is, a transcytotic route via the plasma membrane of the cell body. If PLP transport relies on a transcytotic process, it is reasonable to consider that this myelin protein could be associated with MAL2, a raft protein essential for transcytosis. In this study, carried out with the human oligodendrocytic cell line HOG, we show that PLP colocalized with green fluorescent protein (GFP-MAL2 after internalization from the plasma membrane. In addition, both immunoprecipitation and immunofluorescence assays, indicated the existence of an interaction between GFP-MAL2 and PLP. Finally, ultrastructural studies demonstrated colocalization of GFP-MAL2 and PLP in vesicles and tubulovesicular structures. Taken together, these results prove for the first time the interaction of PLP and MAL2 in oligodendrocytic cells, supporting the transcytotic model of PLP transport previously suggested.

  20. Maltase protein of Ogataea (Hansenula) polymorpha is a counterpart to resurrected ancestor protein ancMALS of yeast maltases and isomaltases

    DEFF Research Database (Denmark)

    Viigand, Katrin; Visnapuu, Triinu; Mardo, Karin

    2016-01-01

    and mutation of the genes. We studied substrate specificity of the maltase protein MAL1 from an earlier diverged yeast, Ogataea polymorpha (Op), in the light of this hypothesis. MAL1 has extended substrate specificity and its properties are strikingly similar to those of resurrected ancMALS. Moreover, amino......, indicating the power of the method to predict substrate binding. Deletion of either the maltase (MAL1) or α-glucoside permease (MAL2) gene in Op abolished the growth of yeast on MAL1 substrates, confirming the requirement of both proteins for usage of these sugars....

  1. Social, societal, and economic burden of mal de debarquement syndrome.

    Science.gov (United States)

    Macke, Allison; LePorte, Andrew; Clark, Brian C

    2012-07-01

    Mal de debarquement syndrome (MdDS) is a disorder of phantom perception of self-motion of unknown cause. The purpose of this work was to describe the quality of life (QOL) of patients with MdDS and to estimate the economic costs associated with this disorder. A modified version of a QOL survey used for another neurological disease (multiple sclerosis; MSQOL-54) was used to assess the impact of MdDS on QOL in 101 patients. The estimated economic costs were based on self-reported direct and indirect costs of individuals living in the United States using Medicare reimbursement payment rates for 2011 in 79 patients. Patients with MdDS reported a poor overall QOL as indicated by a mean composite QOL score of 59.26 ± 1.89 (out of 100). The subcategories having the lowest QOL rating were role limitations due to physical problems (18.32 ± 3.20), energy (34.24 ± 1.47), and emotional problems (36.30 ± 4.00). The overall physical health composite score including balance was 49.40 ± 1.69, and the overall mental health composite score was 52.40 ± 1.83. The cost to obtain a diagnosis was $2,997 ± 337, which included requiring an average of 19 physician visits per patient. The direct cost of MdDS medical care was $826 ± 140 per patient per year, which mainly included diagnostic imaging and physician visits. The indirect costs (i.e., lost wages) were $9,781 ± 2,347 per patient per year. Among 65 patients who were gainfully employed when they acquired MdDS, the indirect costs were $11,888 ± 2,786 per patient per year. Thus, the total annual cost of the disorder ranged from $11,493 ± 2,341 to $13,561 ± 2,778 per patient per year depending on employment status prior to developing MdDS. MdDS negatively and dramatically impacts QOL, and also imposes a substantial economic burden on MdDS patients. These findings underscore the need for further basic and clinical research on MdDS.

  2. Innovación y competitividad del sistema lechero en Valles Centrales de Querétaro. Hacia un modelo de gobernanza territorial

    Directory of Open Access Journals (Sweden)

    Javier Delgadillo Macías

    2017-01-01

    Full Text Available Los objetivos del trabajo consisten en analizar las formas de organización productiva del sistema de lácteos de la región Valles Centrales en Querétaro y reconocer las distintas modalidades de gobernanza que se han construido a partir de la interacción de agentes productivos y de sus incidencias organizativas territoriales. La metodología parte del enfoque milieux innovateurs que permite documentar los efectos del proceso de cambio tecnológico del sistema lácteo respecto del sistema lechero y analizar la competitividad territorial mediante la evaluación de los impactos en el nivel de eficiencia con el cual las empresas combinan sus recursos humanos, tecnológicos y de capital en el ámbito regional. El cuestionamiento general que rige la investigación es: ¿Qué concesiones (ventajas, privilegios, beneficios han construido los actores de este territorio para desplegar procesos de cambio tecnológico efectivos en la competitividad del sistema lácteo regional? Como resultado se encontró que la principal consecuencia de las interacciones locales en torno a la lechería en Querétaro responde a las estrategias del nivel global más que a una visión de desarrollo regional, no obstante poseer este territorio vocación cultural, natural y manifestarse como un medio innovador. La limitación principal se debió a la insuficiente información sobre la organización interna de las grandes empresas del conglomerado estudiado. Las conclusiones señalan cómo el aprovechamiento disímil de los recursos naturales y del potencial humano han redefinido los patrones de especialización lechera y han coadyuvado a concentrar la renta del suelo en un grupo selecto de actores del territorio en estudio.

  3. Estado de mal epiléptico en pediatría

    Directory of Open Access Journals (Sweden)

    Jorge Malagón Valdez

    2013-09-01

    Full Text Available El estado de mal epiléptico es una emergencia médica en la cual se presentan crisis epilépticas por 30 minutos o más de actividad continua, o bien dos o más crisis consecutivas sin recuperación completa de la conciencia entre las mismas. Actualmente se considera que una crisis epiléptica convulsiva o no, que dure más de 5 minuto se deberá considerar un estado de mal epiléptico. Se han utilizado diversos fármacos para el tratamiento de esta patología y sus secuelas. Hay un consenso generalizado en que se debe realizar un manejo agresivo para disminuir su morbi-mortalidad, sin olvidarse que la causa del estado de mal es importante para su manejo, control y sus secuelas.

  4. La seducción del mal en Estrella Distante de Roberto Bolaño

    OpenAIRE

    Montes, Cristian

    2013-01-01

    En el presente artículo se trabajará en torno a la novela Estrella distante de Roberto Bolaño. La intención del análisis será demostrar cómo se expresa y opera la seducción del mal al interior de la representación y proponer cuáles son las formas en que el mal encarna en una figura representativa de la dictadura militar chilena.

  5. Rising Mal-Employment and the Great Recession: The Growing Disconnection between Recent College Graduates and the College Labor Market

    Science.gov (United States)

    Fogg, Neeta P.; Harrington, Paul E.

    2011-01-01

    This article looks at the phenomenon of mal-employment among college graduates in the United States, beginning with an overview of labor-market trends and the effects of the Great Recession on the job-market experiences of young people, including recent college graduates. It then defines "mal-employment" and examines its incidence over…

  6. Maturity and storage influence on the apple (Malus domestica) allergen Mal d 3, a nonspecific lipid transfer protein

    NARCIS (Netherlands)

    Sancho, Ana I.; Foxall, Robert; Rigby, Neil M.; Browne, Thomas; Zuidmeer, Laurian; van Ree, Ronald; Waldron, Keith W.; Mills, E. N. Clare

    2006-01-01

    Consumption of apples can provoke severe allergic reactions, in susceptible individuals, due to the presence of the allergen Mal d 3, a nonspecific lipid transfer protein, found largely in the fruit skin. Levels of Mal d 3 were determined in peel as a function of apple cultivar, position of the

  7. Quem ainda quer ser professor? A opção pela profissão docente por egressos do curso de história da UFMG

    Directory of Open Access Journals (Sweden)

    Marina Alves Amorim

    2014-12-01

    Full Text Available Neste artigo são retratadas as trajetórias profissionais de egressos de uma turma do Curso de História da UFMG, a turma que ingressou na universidade no primeiro semestre de 1998, composta por egressos que, em sua maioria, concluíram a graduação no segundo semestre de 2001 e comemoraram dez anos de formados no segundo semestre de 2011. São destacadas as trajetórias profissionais daqueles que, dez anos após a conclusão do Ensino Superior, são professores da educação básica, especialmente as dos que pretendem continuar trabalhando com o ensino de história, tendo o cuidado de demonstrar como as situações profissionais atuais se conformaram ao longo da graduação e da década que sucedeu a licenciatura. Afinal, quem ainda quer ser professor dez anos depois da graduação em História pela UFMG?

  8. Industria y territorio rural: la constitución de un corredor agropecuario e industrial en el estado de Querétaro

    Directory of Open Access Journals (Sweden)

    Alfonso Serna Jiménez

    2010-01-01

    Full Text Available Los municipios de Ezequiel Montes y Cadereyta se han vuelto un punto de referencia en el análisis de los procesos territoriales de Querétaro, pues han constituido un lugar de actividad primaria vigorosa. Capitales agroalimentarios los han reconocido como un ámbito favorable para la producción avícola, y han invertido en granjas muy tecnificadas en sus territorios rurales, así como en sus vecinos Colón y Tequisquiapan. Estos cuatro municipios han configurado un corredor agroindustrial que ha atraído a maquiladoras y procesadoras de alimentos, entre otras, y es parte de la organización actual del estado, sobre todo ante la desconcentración industrial de la ciudad capital. El objetivo del artículo es destacar la configuración paulatina de un corredor económico distinto a los constituidos por parques industriales y localizado fuera de los corredores nacionales.

  9. Las pymes manufactureras del estado de Querétaro: su modelo de gestión empresarial ante la competitividad de un mundo globalizado

    Directory of Open Access Journals (Sweden)

    Graciela Ayala Jiménez

    2016-03-01

    Full Text Available El proyecto de investigación aborda la caracterización de la orientación emprendedora de los directivos de las mipymes en el estado de Querétaro, de acuerdo con características personales del empresario y organizacionales. Los resultados preliminares arrojan que la innovación depende del grado de educación del empresario, del tamaño de la organización y de la proactividad de la empresa. Se recopilaron 294 cuestionarios aplicados a empresas manufactureras, de información levantada en el año 2009. La recolección de datos se realizó a través de eventos en que los empresarios participan (Canacintra, USEM, Coparmex, AMIQRO, etc., o bien en reuniones donde son citados por el gobierno estatal. El cuestionario aplicado fue el desarrollado por Covin y Slevin (1989, pero fue validado por Kreiser, Marino y Weber (2002, donde se propone que las mediciones de innovación, toma de riesgos y proactividad pueden ser medidos independientemente. Por su parte, Knight (1997 encontró una confi abilidad de más de 0.70 para las tres variables.

  10. A história da escola de educação especial Bem Me Quer – APAE de Toledo – Paraná

    Directory of Open Access Journals (Sweden)

    Ireni Marilene Zago Figueiredo

    2012-08-01

    Full Text Available A APAE de Toledo - PR, fundada no ano de 1974, foi a primeira instituição criada para oferecer o atendimento educacional e social para as pessoas com deficiência no município. Sua instalação ocorreu devido ao empenho de lideranças comunitárias e pais de pessoas com deficiência, que sentiram a necessidade de ter na cidade uma entidade, instituição ou escola para atendimento especializado. Depois de 37 anos de serviços prestados a comunidade toledana, a APAE, que mantém a Escola Especial Bem Me Quer, se destaca como uma das instituições mais importantes na região Oeste do Paraná, oferecendo atendimento especializado para crianças com deficiência na Educação Infantil e no Ensino Fundamental, bem como para os jovens acima de 18 anos no Setor Profissionalizante. O artigo trata, portanto, do histórico da APAE de Toledo – PR, demonstrando que o Setor Profissionalizante foi instalado, em 1996, e reorganizado, em 1998, a partir do Processo de Educação Profissional e Colocação no Trabalho (PECT, com os programas de Iniciação Profissional, Qualificação Profissional e Colocação no Trabalho.

  11. [Modification of fasting blood glucose in adults with diabetes mellitus type 2 after regular soda and diet soda intake in the State of Querétaro, Mexico].

    Science.gov (United States)

    Olalde-Mendoza, Liliana; Moreno-González, Yazmín Esmeralda

    2013-06-01

    The objective of the study was to compare the modification of fasting blood glucose in adults with diabetes mellitus type 2 after intake of regular soda and diet soda. We conducted a randomized clinical trial in clinics of Instituto Mexicano del Seguro Social in Querétaro, México. We included 80 patients with diabetes (mean weight 74.2 +/- 13.66, BMI 30.5 +/- 4.305, waist 98.2 +/- 12.9 and time evolution of diabetes 3.8 +/- 3.009) who were asked to come with fasting for 8 hours and without taking any medicine before testing. They were divided into two groups of 40 subjects, to whom was measured fasting blood glucose after the ingestion of 200 ml of diet soda (with aspartame and acesulfame potassium) or regular soda (without sweetener) we measure glucose at 10, 15 and 30 minutes. For statistical analysis performed we used Student's t-test for dependent and independent samples, and paired t-test, and chi square test (chi2). Capillary glucose levels at 10 minutes were -34.52 and -25.41%, at 15 minutes -48.8 and -36.2% and at 30 minutes 57.75 and 43.6% of absolute and relative differences, with p = 0.000. In conclusion, according to the observations, diet soda doesn't increased blood glucose levels, with a significant difference in fasting decreased at 30 minutes.

  12. Offre pour nos membres

    CERN Multimedia

    Staff Association

    2016-01-01

    Walibi Rhône-Alpes accueille son événement Halloween FreakShow le week-end du 15 et 16 octobre puis tous les jours du 20 octobre au 02 novembre 2016 ! ouverture prolongée jusqu’à 19h et feu d’artifices chaque soir 29, 30 et 31 octobre ! Loup-garou show; 1 labyrinthe; jeu de piste sur le parc (et nombreux lots à gagner); animations (sculpture sur citrouilles et maquillage) et d'autres surpises ! Tarifs pour nos membres : Entrée "Zone terrestre": 23 € au lieu de 29 €. Entrée gratuite pour les enfants de moins de 3 ans, avec accès aux attractions limité. Parking gratuit.

  13. Pengaruh Unsur Alam terhadap Minat Berkunjung Kembali di Mal

    Directory of Open Access Journals (Sweden)

    Riza Septriani Dewi

    2016-12-01

    Full Text Available Pusat perbelanjaan yang berkonsep alam dianggap lebih diminati pengunjung. Penelitian ini mengkaji tentang pengaruh unsur-unsur alam terhadap minat konsumen untuk berkunjung kembali. Variabel yang akan dikaji terdiri dari variabel bebas, yaitu air (diam-bergerak dan vegetasi (tanaman rendah-tanaman tinggi, dan variabel terikat, yaitu persepsi alam dan sikap berkunjung kembali. Penelitian ini menggunakan metode eksperimen stimulus-respon melalui pendekatan kuantitatif dengan prinsip between-subject factorial design. Simulasi gambar digital dari interior pusat perbelanjaan pada 4 kondisi sebagai kombinasi variabel tersebut di atas digunakan sebagai stimulus percobaan, di mana 4 kelompok responden, masing-masing 20 orang, akan menilai stimulus eksperimen dalam kondisi berbeda, atas dasar persepsi alam dan sikap berkunjung kembali. Data eksperimen dihitung dan dianalisa dengan statistik one-way ANOVA. Efek kombinasi variabel air bergerak dan tanaman tinggi ternyata tidak memberikan pengaruh yang signifikan terhadap persepsi alam responden. Efek kombinasi variabel air diam dengan tanaman tinggi tidak memberikan pengaruh yang signifikan terhadap minat responden untuk berkunjung kembali. Namun, efek kombinasi variabel air mengalir dengan tanaman rendah cenderung lebih mengundang persepsi alam yang baik dan minat berkunjung kembali. Hasil eksperimen ini diharapkan dapat menjadi rekomendasi bagi perkembangan ilmu desain dan sebagai salah satu referensi bagi desainer dan pengembang.Kata Kunci: mal; minat berkunjung; persepsi alam; perilaku konsumen.Effects of Natural Elements on Interest to Revisit a MallShopping malls with a natural concept are more attractive to visitors. This study examined the influence of natural interior design elements on client interest to revisit a mall. The assessed elements consisted of independent variables, namely water (still-standing/flowing and vegetation (ground plants/potted plants, and dependent variables, namely nature

  14. Caminhos de um mal-estar de civilização: reflexões intelectuais norte-americanas para pensar a democracia e o negro no Brasil

    Directory of Open Access Journals (Sweden)

    Elizabeth Cancelli

    2010-05-01

    Full Text Available

    Este trabalho tem como objetivo buscar eixos de reflexão desenvolvidos nos Estados Unidos e que foram importantes para repensar a questão da democracia e da cultura no Brasil, especialmente no que diz respeito à inclusão social do negro e à construção de uma identidade brasileira. Assim, as releituras da herança da escravidão verificadas no Sul norte-americano nas primeiras décadas do século XX e o encorajamento para a redefinição da democracia, ocorridos no auge da guerra fria e da cultural war, serão contemplados para a recuperação de vertentes importantes do pensamento brasileiro e sua inserção nos debates em torno desse “mal-estar de civilização”.

  15. MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains

    NARCIS (Netherlands)

    Bijlard, Marjolein; de Jonge, Jenny C.; Klunder, Bert; Nomden, Anita; Hoekstra, Dick; Baron, Wia

    2016-01-01

    In oligodendrocytes (OLGs), an indirect, transcytotic pathway is mediating transport of de novo synthesized PLP, a major myelin specific protein, from the apical-like plasma membrane to the specialized basolateral-like myelin membrane to prevent its premature compaction. MAL is a well-known

  16. Synthesis, crystal structure and magnetic properties of [Cu(mal)(abpt ...

    African Journals Online (AJOL)

    Complex 1 consist of a neutral mononuclear [Cu(mal)(abpt)(H2O)] unit and water molecule of crystallization in a distorted square pyramidal coordination sphere, while complex 2 is viewed as being made up of [Cu(sq)(abpt)2] units with the squarato ligand bridging the two copper(II) cations. Variable temperature magnetic ...

  17. Preparation of MAl O : Eu2+, Sm3+ (M = Ca, Sr, Ba) Phosphors by ...

    African Journals Online (AJOL)

    NJD

    2007-10-15

    Oct 15, 2007 ... clearly show that most peaks are assigned to those of the MAl2O4 structure. Moreover, their structures change with change of M. Samples A and B exhibit monoclinic crystal systems and sample. C a hexagonal structure. The doping Eu2+ and co-doping Sm3+ have very little influence on the structure of the ...

  18. Mal de Meleda: A Report of Two Cases In One Family

    Directory of Open Access Journals (Sweden)

    M.Kantor

    2006-08-01

    Full Text Available Mal de Meleda is a rare autosomal recessive skin disorder, characterized by transgressive palmoplantar keratoderma, lichenoid skin lesions, perioral erythema, brachydactyly and nail abnormalities. We are reporting two cases of a clinically typical disease in a family. No consanguineous relationship between the parents was known and cases could not be detected in three generations of the patient's family.

  19. Preparation of MAl 2 O 4 : Eu 2+ , Sm 3+ (M = Ca, Sr, Ba) Phosphors ...

    African Journals Online (AJOL)

    A series of MAl2O4: Eu2+, Sm3+ (M = Ca, Sr, Ba) phosphors was prepared by the combustion method, and the influence of these alkaline earth metals on the structure and luminescent performances for these phosphors was investigated. A relationship was established between their composition, crystallization capacity and ...

  20. Surto de malária induzida entre usuários de drogas injetáveis Outbreak of malaria among injectable-drug users

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Barradas Barata

    1993-02-01

    Full Text Available Em julho de 1990, foi registrado na cidade de Bauru, Estado de São Paulo, Brasil, um surto de malária envolvendo usuários de cocaína injetável. Uma ampla investigação epidemiológica, conduzida de 19 de julho a 13 de setembro, revelou que pelo menos 119 pessoas estavam envolvidas no surto, uma vez que haviam compartilhado seringas e agulhas com um ou mais casos confirmados nos 3 meses anteriores à ocorrência. Cento e duas dessas pessoas foram localizadas e entrevistadas, e destas, 99 foram submetidas a exame de gota espessa e 91 a exames sorológicos para malária. Foram confirmados por exame hemoscópico 21 casos de malária por P. vivax, e 3 outros tiveram exame sorológico positivo para P. vivax. O controle da transmissão foi obtido fornecendo-se cloroquina aos envolvidos no surto, numa dose inicial de 10 comprimidos, seguida de doses supressivas semanais de 2 comprimidos até que fosse identificado o último comunicante. Amostras de soro coletadas na ocasião revelaram, ao lado da malária, uma alta prevalência de infecções pelo HIV (58% e pelo vírus da hepatite B (40%. Foram discutidas as dificuldades para o controle do surto e a possibilidade da malária vir a se tornar uma doença endêmica entre usuários de drogas injetáveis, no Estado de São Paulo.Five cases of malaria were detected among cocaine users by the local health service in Bauru, a city with a population of 260,000, located 324 km from S. Paulo, Brazil, during the first three weeks of July 1990. Autochthonous malaria had not occurred in Bauru since 1978, and all the five cases denied having recently traveled to endemic areas. An extensive epidemiologic survey conducted from July 19 to September 13 revealed that the 5 cases were in fact part of a malaria outbreak among endovenous drug users. Moreover, at least 114 other people, who had in the last three months shared syringes and needles with one or more proved cases, were also involved in the outbreak. One

  1. Teste de hemaglutinação na sorologia da malária humana empregando hemácias parasitadas pelo Plasmodium berghei

    Directory of Open Access Journals (Sweden)

    Maria Carmen Arroyo Sanchez-Ruiz

    1985-06-01

    Full Text Available Foi padronizado um teste de hemaglutinação para a sorologia da malária humana, com reagente constituído de suspensão de hemácias de camundongos infectadas pelo Plasmodium berghei e preservadas por fixação aldeídica. Em pacientes com parasitemia por P. falciparum ou P. vivax obteve-se uma sensibilidade de 98,9% nos 88 casos estudados, o teste apresentando títulos entre 40 e 640. Para o grupo de 476 soros de indivíduos não-maláricos, obteve-se uma especificidade de 96,0%. O teste apresentou elevada reprodutibilidade, mesmo para diferentes lotes de antígenos. Nos 200 soros, obtidos ao acaso, de indivíduos de área endêmica, o teste apresentou positividade de 48,5%, contra 88,0% do teste de imunofluorescência-IgG. A baixa positividade pode ser devida a que o teste de hemaglutinação detecta anticorpos IgM. Após tratamento com 2-mercaptoetanol, todos os soros de pacientes com parasitemia tornaram-se não reagentes. Em relação ao teste de imunofluorescência-IgG, o teste de hemaglutinação apresentou índice de co-positívidade de 0,989 para os soros de maláricos com parasitemia. Para os soros de não-maláricos o teste de hemaglutinação apresentou índice de co-negatividade de 0,969. Por outro lado, no grupo de soros de área endêmica, o índice de co-positividade foi de 0,528 e o de co-negatividade, de 0,833.A hemagglutination test is described for human malaria serodiagnosis with aldehyde-fixed Plasmodium berghei infected mouse erythrocytes. In patients with a P. falciparum or P. vivax patent parasitemia positive results were seen in 98.9% ofthe 88 cases tested. Titres rangedfrom 40 to 640. A 96.0% specificity wasfoundfor 476 non-malarialpatients. A close reproducibility was observed forthe test, even for dijferent reagent batches. The test was positive in 48.5% of 200 residents in malaria endemic areas, taken at random. These subjects showed 88.0% positivity of the IgG-immunofluorescence test. This lower positivity for

  2. High temperature increases the masculinization rate of the all-female (XX) rainbow trout "Mal" population.

    Science.gov (United States)

    Valdivia, Karina; Jouanno, Elodie; Volff, Jean-Nicolas; Galiana-Arnoux, Delphine; Guyomard, René; Helary, Louise; Mourot, Brigitte; Fostier, Alexis; Quillet, Edwige; Guiguen, Yann

    2014-01-01

    Salmonids are generally considered to have a robust genetic sex determination system with a simple male heterogamety (XX/XY). However, spontaneous masculinization of XX females has been found in a rainbow trout population of gynogenetic doubled haploid individuals. The analysis of this masculinization phenotype transmission supported the hypothesis of the involvement of a recessive mutation (termed mal). As temperature effect on sex differentiation has been reported in some salmonid species, in this study we investigated in detail the potential implication of temperature on masculinization in this XX mal-carrying population. Seven families issued from XX mal-carrying parents were exposed from the time of hatching to different rearing water temperatures ((8, 12 and 18°C), and the resulting sex-ratios were confirmed by histological analysis of both gonads. Our results demonstrate that masculinization rates are strongly increased (up to nearly two fold) at the highest temperature treatment (18°C). Interestingly, we also found clear differences between temperatures on the masculinization of the left versus the right gonads with the right gonad consistently more often masculinized than the left one at lower temperatures (8 and 12°C). However, the masculinization rate is also strongly dependent on the genetic background of the XX mal-carrying families. Thus, masculinization in XX mal-carrying rainbow trout is potentially triggered by an interaction between the temperature treatment and a complex genetic background potentially involving some part of the genetic sex differentiation regulatory cascade along with some minor sex-influencing loci. These results indicate that despite its rather strict genetic sex determinism system, rainbow trout sex differentiation can be modulated by temperature, as described in many other fish species.

  3. Implementación del Sistema Multimodal de Educación de la Universidad Autónoma de Querétaro, México

    Directory of Open Access Journals (Sweden)

    Teresa Guzmán Flores

    2016-11-01

    Full Text Available Los sistemas multimodales de educación son una respuesta efectiva a las necesidades educativas de personas que participan en procesos de aprendizaje con ambientes tecnológicamente enriquecidos, donde el internet es un servicio fundamental. Sin embargo, la institucionalización de esos sistemas en las universidades implica varios desafíos organizacionales. La metodología de transversalización de la innovación educativa es útil para provocar transformaciones estructurales que favorecen la institucionalización de sistemas multimodales porque influye verticalmente (en todos los niveles de decisión y horizontalmente (en todos los procesos vitales de la educación multimodal, provocando productos y servicios innovadores. La implementación del Sistema Multimodal de Educación de la Universidad Autónoma de Querétaro, México, fue conducida con dicha metodología y se obtuvieron los resultados previstos. No obstante, en la operación diaria están surgiendo varios desafíos no previstos. Ha sido necesario analizar dos puntos cruciales: a se está produciendo cierto estrés procedimental en el equipo de producción de materiales digitales debido a una alta demanda; y b si se hubiese garantizado la presencia del personal de los ámbitos normativos, financieros, administrativos y de tecnología educativa, en el proceso de transversalización horizontal (en todos los procesos vitales de la educación multimodal, actualmente estarían más armonizados dichos procedimientos.

  4. Principales géneros bacterianos aislados de leche de cabra en dos granjas del municipio de Tequisquiapan, Querétaro, México

    Directory of Open Access Journals (Sweden)

    Rocío Angélica Ruiz Romero

    2013-01-01

    Full Text Available El término "mastitis" se utiliza para referirse a la inflamación de la glándula mamaria. A pesar de las pérdidas económicas que produce en cabras lecheras, existe escasa información relativa al estado epidemiológico de la misma en nuestro país. El objetivo de este trabajo fue identificar bacterias presentes en leche cruda de cabras clínicamente sanas, obtenida en sistemas de producción intensivo y semi-intensivo por métodos microbiológicos tradicionales. Se trabajaron con 28 animales en sistema de producción intensiva y 33 animales en sistema de producción semiintensiva, provenientes del Centro de Enseñanza, Investigación y Extensión en Producción Animal en Altiplano (CEIEPAA perteneciente a la FMVZ-UNAM y la granja del Carmen, ambas ubicadas en Tequisquiapan, Querétaro, México. De cada una de las cabras se obtuvieron muestras de ambas glándulas, se realizaron muestreos cada 45 días junto con la prueba de California de las cabras seleccionadas hasta los 240 días de lactación. Se recibieron un total de 484 muestras para análisis bacteriológico tradicional, 90 muestras (18.6 % presentaron crecimiento bacteriano, de las cuales se recuperaron 97 aislados. Los géneros bacterianos aislados con mayor frecuenciafueron Staphylococcus coagulasa Negativo (SCN 62/97 (63.9 %, Streptococus uberis 10/97 (10.3 % y Staphylococcus aureus 5/97 (5.1 %. De acuerdo al análisis estadístico, no existen diferencias entre los dos principales géneros bacterianos aislados en ambos sistemas de producción.

  5. NOAA NOS SOS, EXPERIMENTAL - Currents

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have currents data. *These services are for testing and evaluation use...

  6. NOAA NOS SOS, EXPERIMENTAL - Wind

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have wind data. *These services are for testing and evaluation use only*...

  7. Ecología del crecimiento de una lagartija del género Xenosaurus Peters 1861 (Squamata: Xenosauridae en la Reserva de la Biosfera, Sierra Gorda, Querétaro, México Growth ecology of a lizard of the genus Xenosaurus Peters 1861 (Squamata: Xenosauridae from the Biosphere Reserve, Sierra Gorda, Querétaro, México

    Directory of Open Access Journals (Sweden)

    J. GASTÓN ZAMORA-ABREGO

    2012-09-01

    Full Text Available Analizamos el crecimiento corporal de una nueva especie de lagartija endémica del género Xenosaurus Peters, ubicada en la Reserva de la Biósfera, Sierra Gorda - Querétaro, México. Se estimaron las tasas de crecimiento corporal y se analizaron a partir de los modelos de crecimiento de Von Bertalanffy, logístico por longitud y logístico por peso. Para describir el patrón de crecimiento de estas lagartijas, utilizamos el modelo logístico por longitud debido a que fue el modelo que tuvo el mejor ajuste a las tasas observadas de crecimiento corporal. No encontramos diferencias significativas entre machos y hembras en el parámetro característico de crecimiento ni en la talla asintótica proyectada. Por lo tanto, se construyó una sola curva de crecimiento para ambos sexos. Los machos alcanzan la madurez sexual a los 24 meses, mientras que las hembras lo hacen hasta los 37 meses. Las tasas de crecimiento independientes de la talla no fueron estadísticamente diferentes entre años (2001, 2002 y 2003, ni entre estaciones (estación húmeda y seca. Nuestros resultados sugieren que la variación en el crecimiento corporal de esta especie, no es causada exclusivamente por las variaciones ambientales, sino más bien por una compleja combinación de factores ambientales y bases genéticas.We analyzed variation in body growth of a new lizard species of the genus Xenosaurus Peters that is endemic to the Biosphere Reserve, Sierra Gorda - Querétaro, México. We calculated body growth rates and analyzed them by means of the Von Bertalanffy, logistic-by-length, and logistic-by-weight growth models. We used the logistic-by-length model to describe the growth pattern of these lizards because this model provided the best fit to the observed body growth rates. No significant differences were found between males and females in the characteristic growth parameter or in the projected asymptotic size. Therefore, a single growth curve was constructed for both

  8. [Eugen Helimski, Urlike Kahrs. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903)] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2003-01-01

    Raamatust: Helimski, Eugen, Kahrs, Urlike. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903). Hamburg, 2001. (Hamburger Sibirische und Finnisch-Ugrische Materialen / Habent Sua Fata Manuscripts; 1)

  9. La Seducción del mal en estrella distante de Roberto Bolaño

    OpenAIRE

    Montes, Cristian

    2013-01-01

    En el presente artículo se trabajará en torno a la novela Estrella distante de Roberto Bolaño. La intención del análisis será demostrar cómo se expresa y opera la seducción del mal al interior de la representación y proponer cuáles son las formas en que el mal encarna en una figura representativa de la dictadura militar chilena. This article is based on the Roberto Bolaño novel Estrella Distante. The analysis aims to demonstrate the ways that the seduction of evil is expressed and operates...

  10. Une localisation exceptionnelle de la tuberculose vertébrale Mal de Pott sous-occipital

    Science.gov (United States)

    Yahyaoui, Sana; Majdoub, Senda; Zaghouani, Houneida; Fradj, Hosni Ben; Bakir, Dejla; Bouajina, Elyes; Kraiem, Chakib

    2013-01-01

    Le mal de Pott est la forme la plus commune de la tuberculose osseuse touchant essentiellement le rachis dorso-lombaire. La localisation sous-occipitale reste exceptionnelle. Le diagnostic de cette entité est le plus souvent tardif ce qui expose à des complications graves. Les radiographies standard ne sont parlantes qu’à un stade tardif de la maladie, d'où l'intérêt de l'imagerie moderne notamment la tomodensitométrie (TDM) et l'imagerie par résonance magnétique (IRM) qui permettent un diagnostic précoce. Nous rapportons un nouveau cas de tuberculose sous-occipitale. Le diagnostic était posé sur l'imagerie en coupe et confirmé histologiquement à la biopsie transorale. Sont rappelés les aspects en imagerie de cette localisation particulière du mal de Pott. PMID:23819005

  11. Rotational Mal-Alignment after Reamed Intramedullary Nailing for tibial shaft fracture.

    Science.gov (United States)

    Khan, Sher Baz; Mohib, Yasir; Rashid, Rizwan Haroon; Rashid, Haroonur

    2016-10-01

    Intra-medullary (IM) nailing is standard of care for unstable tibial shaft fractures. Malrotation is very common but it is under-recognised, inpart because of variation in normal anatomy and partly due to difficulty in accurately assessing rotation. This study was planned to evaluate the frequency of rotational mal-alignment after reamed tibia IMnailing. This cross-sectional study was conducted at Aga khan University Hospital, Karachi, and comprised patients with tibia shaft fractures managed with IMnailing from January to December 2014. All the patients were assessed intra-operatively for rotational alignment using the knee and ankle fluoroscopic images. There were 81 patients with a mean age of 38±16.9 years. There were 64(79%) male patients. Overall the incidence of malrotation was in 20(24.7%) cases. Rotational mal-alignment is one of the preventable complications after IMnailing which can be assesed intra-operatively under fluoroscope.

  12. SmartMal: a service-oriented behavioral malware detection framework for mobile devices.

    Science.gov (United States)

    Wang, Chao; Wu, Zhizhong; Li, Xi; Zhou, Xuehai; Wang, Aili; Hung, Patrick C K

    2014-01-01

    This paper presents SmartMal--a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users' regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices.

  13. ANALISA PERBEDAAN MOTIVASI DAN PERSEPSI BERBELANJA DI MAL ANTARA ORANG TUA (IBU DAN PARA REMAJA PUTRINYA

    Directory of Open Access Journals (Sweden)

    Sasung Luckytawati

    2008-10-01

    The conceptual framework consists of the following constructs: consumption motivation social and con umption motivation objective as independent variables, and Mall Perception that consist ambience, design, layout, variety, excitement, involvement, desire to stay and desire to return as dependent variable. Moreover, five hypotheses were developed and tested. instrument test of validity and reliability used to test the measures, while independent t-test and multiple regressions were used in hypotheses testing. Data were collected from 100 dyadic pairs of mothers and daughters who had recently visited Mal at Jakarta. The resuIts indicate that mothers and daughters are motivated to consume by different factors, and tha they differ significantly in terms of their perceptions of critical mal environmental variables. Keywords: Consumption motivation social, Consumer behaviour, Mall Perception, and Design factors.

  14. Delayed surgical treatment for neglected or mal-reduced talar fractures.

    Science.gov (United States)

    Huang, Peng-Ju; Cheng, Yuh-Min

    2005-10-01

    From 1993 to 2002, we treated nine patients for neglected or mal-reduced talar fractures. Average patient age was 39 (20-64) years and average follow-up 53 months. The time interval between injury and index operation ranged from 4 weeks to 4 years. Surgical procedures included open reduction with or without bone grafting in six cases, open reduction combined with ankle fusion in one case, talar neck osteotomy in one case, and talar neck osteotomy combined with subtalar fusion in one case. All cases had solid bone union. One patient developed avascular necrosis of the talus needing subsequent ankle arthrodesis. In six patients, adjacent hindfoot arthrosis occurred. The overall AOFAS ankle-hindfoot score was in average 77.4. We conclude that in neglected and mal-reduced talar fractures, surgical treatment can lead to a favourable outcome if the hindfoot joints are not arthritic.

  15. Ablative fractional laser enhances MAL-induced PpIX accumulation

    DEFF Research Database (Denmark)

    Haak, C S; Christiansen, K; Erlendsson, Andrés M

    2016-01-01

    BACKGROUND AND OBJECTIVES: Pretreatment of skin with ablative fractional laser enhances accumulation of topical provided photosensitizer, but essential information is lacking on the interaction between laser channel densities and pharmacokinetics. Hence our objectives were to investigate how...... (range 46-133min) induced fluorescence levels similar to curettage and 180min incubation. Furthermore, MAL 80 and 160mg/g induced similar fluorescence intensities in skin exposed to laser densities of 1, 2 and 5% (p>0.0537, 30-180min). CONCLUSION: MAL-induced protoporphyrin accumulation is augmented...... protoporphyrin accumulation was affected by laser densities, incubation time and drug concentration. METHODS: We conducted the study on the back of healthy male volunteers (n=11). Test areas were pretreated with 2940nm ablative fractional Er:YAG laser, 11.2mJ per laser channel using densities of 1, 2, 5, 10...

  16. Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum

    International Nuclear Information System (INIS)

    Holmes, Margaret A.; Buckner, Frederick S.; Van Voorhis, Wesley C.; Mehlin, Christopher; Boni, Erica; Earnest, Thomas N.; DeTitta, George; Luft, Joseph; Lauricella, Angela; Anderson, Lori; Kalyuzhniy, Oleksandr; Zucker, Frank; Schoenfeld, Lori W.; Hol, Wim G. J.; Merritt, Ethan A.

    2006-01-01

    The crystal structure of a conserved hypothetical protein, MAL13P1.257 from P. falciparum, has been determined at 2.17 Å resolution. The structure represents a new protein fold and is the first structural representative for Pfam sequence family PF05907. The structure of a conserved hypothetical protein, PlasmoDB sequence MAL13P1.257 from Plasmodium falciparum, Pfam sequence family PF05907, has been determined as part of the structural genomics effort of the Structural Genomics of Pathogenic Protozoa consortium. The structure was determined by multiple-wavelength anomalous dispersion at 2.17 Å resolution. The structure is almost entirely β-sheet; it consists of 15 β-strands and one short 3 10 -helix and represents a new protein fold. The packing of the two monomers in the asymmetric unit indicates that the biological unit may be a dimer.

  17. Torsional vibration analysis in turbo-generator shaft due to mal-synchronization fault

    Science.gov (United States)

    Bangunde, Abhishek; Kumar, Tarun; Kumar, Rajeev; Jain, S. C.

    2018-03-01

    A rotor of turbo-generator shafting is many times subjected to torsional vibrations during its lifespan. The reasons behind these vibrations are three-Phase fault, two-phase fault, line to ground fault, faulty-mal synchronization etc. Sometimes these vibrations can cause complete failure of turbo-generator shafting system. To calculate moment variation during these faults on the shafting system vibration analysis is done using Finite Elements Methods to calculate mass and stiffness matrix. The electrical disturbance caused during Mal-synchronization is put on generator section, and corresponding second order equations are solved by using “Duhamel Integral”. From the moment variation plots at four sections critically loaded sections are identified.

  18. Magnetic moment of short lived {beta}-emitter {sup 24m}Al

    Energy Technology Data Exchange (ETDEWEB)

    Nishimura, D., E-mail: daiki@vg.phys.sci.osaka-u.ac.jp; Komurasaki, J.; Matsuta, K.; Mihara, M.; Matsumiya, R. [Osaka University, Department of Physics (Japan); Momota, S. [Kochi University of Technology (Japan); Ohtsubo, T. [Niigata University, Department of Physics (Japan); Izumikawa, T. [Niigata University, RI Center (Japan); Hirano, H. [Niigata University, Department of Physics (Japan); Kitagawa, A.; Kanazawa, M.; Torikoshi, M.; Sato, S. [National Institute of Radiological Sciences (Japan); Fukuda, M.; Ishikawa, D. [Osaka University, Department of Physics (Japan); Minamisono, T. [Fukui University of Technology (Japan); Watanabe, R.; Kubo, T. [Niigata University, Department of Physics (Japan); Nojiri, Y. [Kochi University of Technology (Japan); Alonso, J. R. [Lawrence Berkeley Laboratory (United States)

    2007-11-15

    The magnetic moment of short lived {beta}-emitter {sup 24m}Al (426 keV, I{sup {pi}} = 1{sup +}, T{sub 1/2} = 131 ms) has been measured by means of {beta}-NMR technique, for the first time. From the {beta}-NMR spectrum, the magnetic moment was determined as |{mu}({sup 24m}Al)|=(2.99{+-}0.09){mu}{sub N}. Combined with the known magnetic moment of the mirror partner {sup 24m}Na, the expectation value of < S{sub z} > is obtained to be (0.08 {+-} 0.12). These values are reproduced well by the shell model calculation.

  19. Theoretical Characteristics of Metalloporphyrins (OEP) M (CH 3 ) (M=Al, Ga, In and Tl)

    OpenAIRE

    Lepetit , M.B.; Kabbaj , O.K.; Zrineh , A.

    2017-01-01

    International audience; A theoretical study of metalloporphyrins molecules (OEP) M (CH 3) (M=Al, Ga, In and Tl) are brought to a few experimental data and to give background for future development of these complexes. The Quantum Chemistry Program (ORCA) program package based on Density Functional Theory (DFT) and Time-dependent Density Functional Theory (TDDFT) for transitions at the B3LYP level with ANO 2ζ+P base was used for calculations and determination of structural properties, electroni...

  20. The (Mal)Practice of Dowry in Contemporary India. A Challenge to Marriage and Family Ministry

    OpenAIRE

    Jainus Xavier, Nixen Raj; Jainus Xavier, Nixen Raj; Knieps-Port le Roi, Thomas

    2012-01-01

    The author explores the (mal)practice of dowry in contemporary India and the challenge it presents to marriage and family ministry. He explains how originally harmless and well-intended dowry customs changed under the influence of historical circumstances that turned them into a business-like family strategy aimed at rising families’ social status, wealth and power. This evolution had dramatic consequences for Indian marriage and family life and especially for women. Dowry-related violence an...

  1. O ensino da contabilidade internacional nos cursos de graduação em ciências contábeis do Brasil

    OpenAIRE

    Echternacht, Tiago Henrique de Souza

    2010-01-01

    Esta pesquisa teve como objetivo avaliar a inserção da Contabilidade Internacional nos cursos de graduação em Ciências Contábeis na forma da resolução nº10 do Conselho Nacional de Educação do MEC, nas 87 (oitenta e sete) universidades/faculdades brasileiras, por meio de levantamento de dados visando: conhecer os métodos e meios de ensino utilizados na disciplina, bem como avaliar o estágio atual quanto a sua adoção quer como disciplina específica ou como parte integrante de outra disciplina, ...

  2. Hybrid (laparoscopy + stent) treatment of celiac trunk compression syndrome (Dunbar syndrome, median arcuate ligament syndrome (MALS)).

    Science.gov (United States)

    Michalik, Maciej; Dowgiałło-Wnukiewicz, Natalia; Lech, Paweł; Majda, Kaja; Gutowski, Piotr

    2016-01-01

    Celiac trunk (CT) compression syndrome caused by the median arcuate ligament (MAL) is a rarely diagnosed disease because of its nonspecific symptoms, which cause a delay in the correct diagnosis. Intestinal ischemia occurs, which causes symptoms of abdominal angina. One method of treatment for this disease is surgical release of the CT - the intersection of the MAL. Laparoscopy is the first step of the hybrid technique combined with percutaneous angioplasty and stenting of the CT. To demonstrate the usefulness and advantages of the laparoscopic approach in the treatment of Dunbar syndrome. Between 2013 and 2016 in the General and Minimally Invasive Surgery Department of the Medical Sciences Faculty of the University of Warmia and Mazury in Olsztyn, 6 laparoscopic procedures were performed because of median arcuate ligament syndrome. During the laparoscopy the MAL was cut with a harmonic scalpel. One month after laparoscopy 5 patients had Doppler percutaneous angioplasty of the CT with stent implantation in the Vascular Surgery Department in Pomeranian Medical University in Szczecin. In one case, there was a conversion of laparoscopic surgery to open due to unmanageable intraoperative bleeding. In one case, postoperative ultrasound examination of the abdominal cavity demonstrated the presence of a large hematoma in the retroperitoneal space. All patients reported relief of symptoms in the first days after the operation. The hybrid method, combining laparoscopy and angioplasty, seems to be a long-term solution, which increases the comfort of the patient, brings the opportunity for normal functioning and minimizes the risk of restenosis.

  3. Costo de oportunidad en hombres que acuden a las unidades de medicina familiar en la ciudad de Querétaro, México Opportunity cost for men who visit family medicine units in the city of Querétaro, Mexico

    Directory of Open Access Journals (Sweden)

    Edith Olimpia Martínez Carranza

    2010-12-01

    Full Text Available OBJETIVO: Determinar el costo de oportunidad en hombres que solicitan atención en las unidades de medicina familiar (UMF del Instituto Mexicano del Seguro Social (IMSS en la ciudad de Querétaro. MÉTODOS: Se seleccionó una muestra de 807 hombres de 20 a 59 años de edad que solicitaban atención en los servicios de medicina familiar, laboratorio y farmacia, proporcionados por UMF del IMSS en Querétaro. Se excluyeron los pacientes referidos a urgencias y los que se retiraron sin recibir atención. La muestra (n = 807 se calculó mediante la fórmula de promedios para población infinita, con un intervalo de confianza de 95% (IC95% y un costo de oportunidad promedio de US$ 5,5 para medicina familiar, US$ 3,1 para laboratorio y de US$ 2,3 para farmacia. Las estimaciones incluyeron el tiempo invertido en traslado, espera y atención; el número de acompañantes, y el costo del minuto para la actividad remunerada y no remunerada. El costo de oportunidad se calculó a través del costo por minuto estimado para traslado, espera y atención de pacientes y acompañantes. RESULTADOS: El costo de oportunidad correspondiente al traslado del paciente se estimó en US$ 0,97 (IC95%: 0,81-1,15, mientras que el de espera fue de US$ 5,03 (IC95%: 4,08-6,09 en medicina familiar, US$ 0,06 (IC95%: 0,05-0,08 en farmacia y US$ 1,89 (IC95%: 1,56- 2,25 en laboratorio. El costo de oportunidad promedio cuando el paciente acudió sin compañía osciló entre US$ 1,10 para el servicio de farmacia solo y US$ 8,64 para medicina familiar, farmacia y laboratorio. El costo de oportunidad ponderado para medicina familiar fue de US$ 6,24. CONCLUSIONES: Dado que el costo de oportunidad de los hombres que demandan servicios en las unidades de medicina familiar corresponde a más de la mitad de un salario mínimo, desde el enfoque institucional correspondería establecer si esa es la mejor alternativa de atención.OBJECTIVE: To determine the opportunity cost for men who seek care

  4. MAL2 and tumor protein D52 (TPD52 are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

    Directory of Open Access Journals (Sweden)

    Fanayan Susan

    2010-09-01

    Full Text Available Abstract Background The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52, which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Methods Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. Results MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours. MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas. MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p Conclusions MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients.

  5. Maltase protein of Ogataea (Hansenula) polymorpha is a counterpart to the resurrected ancestor protein ancMALS of yeast maltases and isomaltases

    Science.gov (United States)

    Viigand, Katrin; Visnapuu, Triinu; Mardo, Karin; Aasamets, Anneli

    2016-01-01

    Abstract Saccharomyces cerevisiae maltases use maltose, maltulose, turanose and maltotriose as substrates, isomaltases use isomaltose, α‐methylglucoside and palatinose and both use sucrose. These enzymes are hypothesized to have evolved from a promiscuous α‐glucosidase ancMALS through duplication and mutation of the genes. We studied substrate specificity of the maltase protein MAL1 from an earlier diverged yeast, Ogataea polymorpha (Op), in the light of this hypothesis. MAL1 has extended substrate specificity and its properties are strikingly similar to those of resurrected ancMALS. Moreover, amino acids considered to determine selective substrate binding are highly conserved between Op MAL1 and ancMALS. Op MAL1 represents an α‐glucosidase in which both maltase and isomaltase activities are well optimized in a single enzyme. Substitution of Thr200 (corresponds to Val216 in S. cerevisiae isomaltase IMA1) with Val in MAL1 drastically reduced the hydrolysis of maltose‐like substrates (α‐1,4‐glucosides), confirming the requirement of Thr at the respective position for this function. Differential scanning fluorimetry (DSF) of the catalytically inactive mutant Asp199Ala of MAL1 in the presence of its substrates and selected monosaccharides suggested that the substrate‐binding pocket of MAL1 has three subsites (–1, +1 and +2) and that binding is strongest at the –1 subsite. The DSF assay results were in good accordance with affinity (K m) and inhibition (K i) data of the enzyme for tested substrates, indicating the power of the method to predict substrate binding. Deletion of either the maltase (MAL1) or α‐glucoside permease (MAL2) gene in Op abolished the growth of yeast on MAL1 substrates, confirming the requirement of both proteins for usage of these sugars. © 2016 The Authors. Yeast published by John Wiley & Sons, Ltd. PMID:26919272

  6. Causas mal definidas de morte e óbitos sem assistência Ill-defined causes of death and unattended deaths, Brazil, 2003

    Directory of Open Access Journals (Sweden)

    Augusto Hasiak Santo

    2008-02-01

    Full Text Available OBJETIVOS: Este trabalho estuda a distribuição dos óbitos por causas mal definidas no Brasil, no ano de 2003, entre as quais identifica a proporção de mortes sem assistência. MÉTODOS: Os dados provieram do Sistema de Informações Sobre Mortalidade, coordenado pelo Ministério da Saúde. As causas mal definidas de morte compreenderam as incluídas no "Capítulo XVIII - Sintomas, sinais e achados anormais de exames clínicos e de laboratório não classificados em outra parte" da Classificação Estatística Internacional de Doenças e Problemas Relacionados à Saúde, décima revisão, capítulo este no qual a categoria R98 identificava a "morte sem assistência". RESULTADOS: No Brasil, em 2003, a causa básica de 13,3% dos óbitos foi identificada como mal definida, sendo que as proporções maiores ocorreram nas Regiões Nordeste e Norte. Do total de causas mal definidas no país, 53,3% corresponderam a mortes sem assistência, proporção esta que superou 70% nos Estados do Maranhão, Piauí, Rio Grande do Norte, Pernambuco, Bahia, Paraíba e Alagoas. CONCLUSÃO: Dada a estrutura descentralizada para o levantamento dos óbitos no país, identifica-se a maior responsabilidade dos municípios e, em seguida, dos Estados para o aprimoramento da qualidade das estatísticas de mortalidade.BACKGROUND: We studied the distribution of deaths from ill-defined causes that occurred in Brazil during 2003, from which was identified the proportion of unattended deaths. METHODS: Data were obtained from the Mortality Information System, coordinated by the Ministry of Health. Causes of death included in "Chapter XVIII - Symptoms, signs and abnormal clinical and laboratory findings, not classified elsewhere" of the International Statistical Classification of Diseases and Related Health Problems, tenth revision, were considered ill-defined, among which the category R98 identified "unattended deaths". RESULTS: In Brazil during 2003 the underlying causes of

  7. Performances of air source heat pump system for a kind of mal-defrost phenomenon appearing in moderate climate conditions

    International Nuclear Information System (INIS)

    Wang, W.; Feng, Y.C.; Zhu, J.H.; Li, L.T.; Guo, Q.C.; Lu, W.P.

    2013-01-01

    Highlights: ► Mal-defrost performances of ASHP in moderate environment are investigated. ► The system COP decreases to 2.3 under environment temperature of 7.9 °C. ► The decrease of the ASHP heating capacity can get to 43.4%. ► The origins of this special mal-defrost phenomenon were discussed. ► Suggestions were proposed to modify the current defrosting control strategies. - Abstract: To quantify the performance drop of the air source heat pump (ASHP) system under a special kind of mal-defrost phenomenon appearing in moderate climate conditions, a field test was conducted for 8 days at the initial stage of a heating season in Beijing, China. The mal-defrost was found with the more than 60% frosted area of the outdoor heat exchanger after the system running 5 days. During this frosting period, the system COP was significantly degraded, only 2.3 under an environment temperature of 7.9 °C. Comparing the test data before and after frosting, it was found that the mal-defrost decreased the COP up to 40.4% and the heating capacity to 43.4%. Such low energy efficiency continued quite a long time until the defrost control was started up manually by the authors. After defrosting, the COP reclaimed to the normal level of 5.0. The origins of this special mal-defrost phenomenon were discussed. And some suggestions were proposed to modify the current defrosting control strategy, which were helpful to avoid the mal-defrost problem in the current ASHP system and therefore improve the system performances

  8. Pequeno mal epiléptico em crianças. Considerações sobre o efeito do tridione em 4 casos

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    Antonio B. Lefévre

    1949-03-01

    Full Text Available The author administered Tridione in four patients under five years of age with "petit mal" seizures. In all cases there was complete disappearance of the seizures eventhough small doses were used. In one case the EEG, taken after the Tridione treatment, did not show the previous "petit mal" pattern. In no case there were signs of intolerance. In conclusion the author thoroughly agree that Tridione is the drug of choice in "petit mal" seizures.

  9. DMPD: The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17449723 The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Sh...Show The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. PubmedID 17449723 Title The Tro...ll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Authors Sheedy F

  10. Luminescence properties of Eu2+-doped MAl2-xSixO4-xNx (M = Ca, Sr, Ba) conversion phosphor for white LED applications

    NARCIS (Netherlands)

    Li, Y.Q.; With, de G.; Hintzen, H.T.J.M.

    2006-01-01

    Undoped and Eu-doped MAl2-xSixO4-2Nx (M = Ca, Sr, Ba) were synthesized by a solid-state reaction method at 1300 - 1400 ¿C under nitrogen-hydrogen atmosphere. The solubility of (SiN)+, in MAl2O4 was determined. Nitrogen can be incorporated into MAl2O4 by replacement of (AlO)+ by (SiN)+, whose amount

  11. Aspectos florísticos e fitossociológicos de um trecho de Floresta Estacional Perenifólia na Fazenda Trairão, Bacia do rio das Pacas, Querência-MT Floristic and phytosociological aspects of a Seasonal Evergreen Forest area in the Trairão Farm, rio das Pacas Basin, Querência-MT

    Directory of Open Access Journals (Sweden)

    Sustanis Horn Kunz

    2008-01-01

    Full Text Available A borda sul da região amazônica apresenta um tipo peculiar de floresta, denominada de Floresta Estacional Perenifólia, que atualmente vem sofrendo severos impactos ambientais devido à expansão da fronteira agrícola no Norte do Estado de Mato Grosso. Diante da falta de estudos neste tipo florestal, objetivou-se identificar a composição florística e a estrutura fitossociológica do componente arbóreo de um trecho florestal na Fazenda Trairão em Querência-MT. A amostragem da vegetação consistiu na distribuição de 200 pontos-quadrantes, sendo considerados os quatro indivíduos mais próximos de cada ponto que tivessem DAP (diâmetro à altura do peito igual ou superior a 10 cm. A densidade total foi de 728 ind./ha, distribuídos em 49 espécies, 39 gêneros e 24 famílias. A família que apresentou maior riqueza foi Fabaceae (cinco espécies, seguida por Burseraceae e Euphorbiaceae, cada uma com quatro espécies, consideradas também as mais ricas em trechos de Floresta Amazônica. As espécies de maior Valor de Importância (VI foram Ocotea leucoxylon (Sw. Laness., Xylopia amazonica R.E. Fr., Myrcia multiflora (Lam. DC., Chaetocarpus echinocarpus (Baill. Ducke e Protium pilosissimum Engl., mas não tiveram a mesma representatividade em outros trechos de Floresta Estacional Perenifólia, evidenciando diferenças estruturais desta unidade fitogeográfica. A comunidade avaliada possui porte fino, pois a maioria dos indivíduos concentra-se nas classes de diâmetro entre 10 e 14,9 cm e altura entre 10,6 e 16,5 m. O índice de Shannon (3,17 é considerado baixo por se tratar de floresta amazônica, na qual a diversidade é superior a 4,0.The southern border of the Amazon region presents a peculiar type of forest called Seasonal Evergreen Forest, which has currently undergone several environmental impacts due to the agriculture frontier expansion from the Northern state of Mato Grosso. Due to the lack of studies on this type of forest

  12. A Internet que nos protege

    Directory of Open Access Journals (Sweden)

    Luana Negrelly Saraiva

    2001-02-01

    Full Text Available A partir de uma análise das relações interpessoais nos canais de chat, pretende-se mostrar a Internet como um espaço de proteção da mesma sociedade repressora que a criou, abrindo portas para o desenvolvimento e o resgate dos valores humanos.

  13. Morir por "alferecía" en la Parroquia de Santiago de Querétaro, México: 1838-1851.

    Directory of Open Access Journals (Sweden)

    Luz María Espinosa Cortés

    2017-12-01

    Full Text Available Es un estudio interdisciplinario en el que participan la Historia y la Salud Pública. Objetivo: Dar cuenta de las discusiones entre los médicos occidentales sobre la "alferecía" (enfermedad convulsiva y su construcción como expresión diagnóstica de causa de muerte infantil; conocer la distribución y estacionalidad de las causas de muerte de los menores de 5 años, y conocer la distribución y estacionalidad de los decesos por "alferecía" según grupo etario. Metodología: Análisis histórico y estadístico. Resultados. De enero de 1838 a diciembre de 1851 se registraron 5,358 decesos de todas las edades: 2,649 (49.3 por ciento correspondieron al grupo de 0 a 5 años de edad. Se encontró que la disentería fue la primera causa de muerte en niños de 1 a 5 años; y la "alferecía" en menores de un mes. En este segundo grupo el 81 por ciento murió por "alferecía" durante las dos primeras semanas de vida. Conclusiones: El porcentaje de decesos de menores de un mes por "alferecía" coincidió con el periodo de incubación de la bacteria Clostridium tetani que es de 3 a 28 días, es probable que se debieran al tétanos neonatal o "mal de los siete días". Palabras clave: mortalidad neonatal, enfoque interdisciplinario, afección neurológica, edad por grupo, búsqueda documental en línea, saberes locales

  14. Malária grave em gestantes Severe malaria in pregnant women

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    Flavia Barbosa Fernandes

    2010-12-01

    Full Text Available OBJETIVO: analisar a evolução clínica de três pacientes grávidas com malária grave internadas em unidade de terapia intensiva de um hospital localizado em Porto Velho (RO. MÉTODOS: foi realizado estudo descritivo em três gestantes, portadoras de malária por Plasmodium falciparum, internadas em unidade de terapia intensiva em Porto Velho, no período de 2005 a 2006. As variáveis categóricas utilizadas foram os critérios de classificação da Organização Mundial de Saúde para classificação de malária grave e os índices Acute Physiology and Chronic Health disease Classification System II (APACHE II e Sepsis Related Organ Failure Assessment (SOFA preditores de morbidade e gravidade das doenças em unidade de terapia intensiva. RESULTADOS: a malária adquirida pelas gestantes, caracterizada pela infecção por Plasmodium falciparum na forma grave da doença, resultou em óbito para as três pacientes e seus conceptos. CONCLUSÕES: embora a casuística seja pequena, a importância deste estudo reflete a repercussão da malária grave em gestantes, bem como a necessidade de um acompanhamento pré-natal mais criterioso e atento à identificação precoce do início das complicações da malária em gestantes.PURPOSE: to analyze the clinical course of three pregnant patients with severe malaria admitted to the intensive care unit of a hospital in Porto Velho (RO, Brazil. METHODS: a descriptive study was conducted on three pregnant women infected with Plasmodium falciparum malaria, admitted to the intensive care unit of a hospital in Porto Velho from 2005 to 2006. Categorical variables used were the classification criteria of the World Health Organization which ranks severe malaria and the Acute Physiology and Chronic Health Disease Classification System II (APACHE II and Sepsis Related Organ Failure Assessment (SOFA predictors of morbidity and severity of intensive care unit diseases. RESULTS: the malaria acquired by the pregnant

  15. O desafio da malária: o caso brasileiro e o que se pode esperar dos progressos da era genômica The malaria challenge: the Brazilian case and what can be expected from progress in genomics

    Directory of Open Access Journals (Sweden)

    Luiz Hildebrando Pereira da Silva

    2002-01-01

    Full Text Available A área endêmica de malária no Brasil se estende atualmente à totalidade da região amazônica, com cerca de 500 mil casos anuais, em geral com situações de baixa e média endemicidade mas ainda apresentando focos de alto risco. Fatores demográficos e socioeconômicos são dominantes nos desafios que enfrentam os Serviços de Saúde Pública no controle da malária. No presente artigo são discutidos fatores determinantes da instabilidade da situação endêmica bem como a necessidade de ações permanentes de vigilância e de intervenção dos Serviços de Saúde para que se evitem surtos epidêmicos e alastramento das áreas endêmicas. No artigo, em seguida, apresenta-se uma síntese de progressos recentes nos estudos da era genômica e pós-genômica sobre o parasita, o vetor e o hospedeiro humano que podem favorecer, no futuro, o desenvolvimento e a melhoria dos métodos de controle da malária.Malaria endemic areas in Brazil are restricted to the Amazon Region, with an average of 500 thousand new cases every year. The situation can be defined as unstable hipoendemic with, however, foci of high endemicity. Demographic and socio economic factors are main determinants in the malaria challenge for the Public Health System. In the present paper, biological and social factors responsible for the unstable endemic situation are discussed. The need for a permanent surveillance and intervention of Public Health Services are stressed to avoid the occurrence of local epidemics and spreading of endemic areas. In the paper, are also summarised recent lines of research developed in the post genomic era in the studies of parasite, vector and human molecular genetics that would favour the development, in the future, of new tools and procedures for malaria control

  16. Hybrid (laparoscopy + stent treatment of celiac trunk compression syndrome (Dunbar syndrome, median arcuate ligament syndrome (MALS

    Directory of Open Access Journals (Sweden)

    Maciej Michalik

    2016-12-01

    Full Text Available Introduction : Celiac trunk (CT compression syndrome caused by the median arcuate ligament (MAL is a rarely diagnosed disease because of its nonspecific symptoms, which cause a delay in the correct diagnosis. Intestinal ischemia occurs, which causes symptoms of abdominal angina. One method of treatment for this disease is surgical release of the CT – the intersection of the MAL. Laparoscopy is the first step of the hybrid technique combined with percutaneous angioplasty and stenting of the CT. Aim: To demonstrate the usefulness and advantages of the laparoscopic approach in the treatment of Dunbar syndrome. Material and methods : Between 2013 and 2016 in the General and Minimally Invasive Surgery Department of the Medical Sciences Faculty of the University of Warmia and Mazury in Olsztyn, 6 laparoscopic procedures were performed because of median arcuate ligament syndrome. During the laparoscopy the MAL was cut with a harmonic scalpel. One month after laparoscopy 5 patients had Doppler percutaneous angioplasty of the CT with stent implantation in the Vascular Surgery Department in Pomeranian Medical University in Szczecin. Results : In one case, there was a conversion of laparoscopic surgery to open due to unmanageable intraoperative bleeding. In one case, postoperative ultrasound examination of the abdominal cavity demonstrated the presence of a large hematoma in the retroperitoneal space. All patients reported relief of symptoms in the first days after the operation. Conclusions : The hybrid method, combining laparoscopy and angioplasty, seems to be a long-term solution, which increases the comfort of the patient, brings the opportunity for normal functioning and minimizes the risk of restenosis.

  17. PERTANGGUNGAN JAWAB PIDANA PEJABAT ATAS TINDAKAN MAL-ADMINISTRASI DALAM PENERBITAN IZIN DI BIDANG LINGKUNGAN

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    Ahmad Basuki

    2011-09-01

    Full Text Available The democratic strengthen is very influencing to the demand of good governance in managing the government. One of the positive demand is it has been adopted the principle of accountability of the constitution of protection and management of environment for official functionary on the act of mal administration in establishing permit of environment field, Based on the principle community who become sacrifice of pollution of environment can appeal the legal permit and the responsibility of criminal case towards the official functionary of disadvantages they have got.

  18. Kärnproblem : opinionsbildning i kärnavfallsdiskursen i Malå

    OpenAIRE

    Sjölander, Annika

    2004-01-01

    At the centre of this study lies one of the critical questions faced by (late-)modern society, namely that of taking care of the long-lived radioactive waste from nuclear power production. The problems of nuclear waste management are pictured as embracing a complex web of essential issues for society today, in terms of both its capacities and its shortcomings – so called core issues. The principal aim of the thesis is to examine the nuclear waste discourse in Malå, Västerbotten, from a critic...

  19. No hay mal que por bien no venga: el optimismo según Rousseau

    OpenAIRE

    Baranzelli, Dante A.

    2004-01-01

    El deísmo rousseauniano desestima la existencia del caos o del Mal general. Por el contrario, ve en el sistema del mundo un orden perfecto que obedece a la divina Providencia, identificada con la legalidad universal de la naturaleza. Mas con ello su intención no es despreciar el sufrimiento de los individuos. De hecho Rousseau reconoce y admite la presencia, e incluso la abundancia, de diversos males que afectan al hombre. ¿Acaso él mismo no es un claro ejemplo de ello?

  20. Escaping History: Benjamin Fondane's 'Mal des fantômes' and Interiority

    OpenAIRE

    Dickow, A

    2017-01-01

    AbstractThis article undertakes a detailed comparison of the work of Emmanuel Levinas and the poet-philosopher Benjamin Fondane. Fondane’s most iconic poem, quoted at the entrance to the Hall of Names in Jerusalem’s Holocaust museum, resembles a poetic illustration of Levinas’s key themes, such as the ‘face’ and the concept of ‘ethical speech.’ Likewise, Fondane’s long poem ‘Le Mal des fantômes’ illustrates Levinas and Fondane’s shared conception of the subject’s interiority and day-to-day ex...

  1. Exposure to Glycolytic Carbon Sources Reveals a Novel Layer of Regulation for the MalT Regulon

    Directory of Open Access Journals (Sweden)

    Sylvia A. Reimann

    2011-01-01

    Full Text Available Bacteria adapt to changing environments by means of tightly coordinated regulatory circuits. The use of synthetic lethality, a genetic phenomenon in which the combination of two nonlethal mutations causes cell death, facilitates identification and study of such circuitry. In this study, we show that the E. coli ompR malTcon double mutant exhibits a synthetic lethal phenotype that is environmentally conditional. MalTcon, the constitutively active form of the maltose system regulator MalT, causes elevated expression of the outer membrane porin LamB, which leads to death in the absence of the osmoregulator OmpR. However, the presence and metabolism of glycolytic carbon sources, such as sorbitol, promotes viability and unveils a novel layer of regulation within the complex circuitry that controls maltose transport and metabolism.

  2. A review of the prevalence and factors responsible for mal-nutrition in Pakistan

    Directory of Open Access Journals (Sweden)

    Hafsa Hina

    2015-01-01

    Full Text Available Problems occupying special attention identified by the World Health Organization also include Childhood malnutrition (Beagle hole et al., 1993. Development goals are also program by the United Nations to halve the problem of under nutrition (Alderman et al., 2005. Despite of the involvement of international organizations still under nutrition has a main contribution to the high mortality rate of the children in the most part of the world (Caulfield et al., 2004. Poverty plays a main part in the high prevalence of childhood under nutrition. The child is said to be under-weight when its weight is lower than the weight of the reference rage for that age. The weight for height deficiency is known as wasting, while height for age deficiency as stunting. Wasting may be due to acute food shortage while prolonged food deprivation can cause stunting (Cosminsky et al., 1993; de Onis et al., 2000; Fernandez et al., 2002; and Zere & McIntyre, 2003. The factors responsible for the predisposition of children to mal nutrition vary and ranges from political instability to the economical status of the area (de Onis et al., 2000. Therefore protocols developed for the preventive measures of mal-nutrition should be multifaceted. 

  3. Olhar de dirigentes sindicais sobre qualidade de vida no trabalho e mal-estar no trabalho

    Directory of Open Access Journals (Sweden)

    Remigio Todeschini

    2013-06-01

    Full Text Available O objeto do artigo consistiu em conhecer as percepções de dirigentes sindicais metalúrgicos e químicos sobre o tema Qualidade de Vida no Trabalho (QVT e as fontes de mal-estar no trabalho nessas categorias profissionais. A natureza metodológica aplicada foi quantitativa e qualitativa com utilização do software Alceste. Participaram da pesquisa 81 dirigentes sindicais brasileiros (56 dirigentes químicos e 25 metalúrgicos, 85% do gênero masculino e 15% do gênero feminino oriundos das regiões sudeste, sul e nordeste do país, com aplicação do questionário via e-mail. Os resultados encontrados forneceram bases empíricas para a formulação de recomendações em Ergonomia da Atividade visando prevenir as fontes de mal-estar no trabalho. Foram reforçadas as bases teóricas da Abordagem de Ergonomia da Atividade Aplicada à Qualidade de Vida no Trabalho (EAA_QVT e o desenho de subsídios para a formulação de políticas públicas neste campo.

  4. The use of plasma rich in growth factors (PRGF-Endoret) in the treatment of a severe mal perforant ulcer in the foot of a person with diabetes.

    Science.gov (United States)

    Orcajo, Beatriz; Muruzabal, Francisco; Isasmendi, María Concepción; Gutierrez, Nerea; Sánchez, Mikel; Orive, Gorka; Anitua, Eduardo

    2011-08-01

    A 71 year old person with diabetes with a severe mal perforant ulcer in the right foot was treated twice with autologous plasma-rich in growth factors (PRGF) obtained from her own blood. After PRGF treatment the severe mal perforant ulcer completely healed in 10 weeks. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  5. Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection.

    NARCIS (Netherlands)

    Papadopoulos, A.I.; Ferwerda, B.; Antoniadou, A.; Sakka, V.; Galani, L.; Kavatha, D.; Panagopoulos, P.; Poulakou, G.; Protopapas, K.; Meer, J.W.M. van der; Netea, M.G.; Giamarellos-Bourboulis, E.J.

    2012-01-01

    OBJECTIVES: MyD88 adaptor-like (Mal/TIRAP) is an adaptor protein bridging activation of Toll-like receptors 2 and 4 after stimulation by exogenous and endogenous ligands. We investigated the association between the presence of the S180L SNP of Mal and the risk of severe infection in individuals with

  6. Superconductors for the medium-voltage grid. A superconducting power cable running through the inner city of Essen passes a two-year field test; Supraleiter fuer das Mittelspannungsnetz. Ein supraleitendes Stromkabel quer durch die Essener Innenstadt besteht zweijaehrigen Feldtest

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Franz

    2017-04-01

    Scientists are testing the longest high-temperature superconducting cable in the world under real conditions in Essen. One kilometre long, it connects two substations in the inner city. It replaces a conventional 110 kV line and renders one substation in the inner city obsolete. After two years of testing, it has passed the field test. It could be a blueprint for the future power supply system in urban areas. [German] Wissenschaftler testen in Essen das laengste Hochtemperatur-Supraleiterkabel der Welt unter realen Bedingungen. Mit einer Laenge von einem Kilometer verbindet es zwei Umspannstationen quer durch die Innenstadt. Es ersetzt eine konventionelle 110-kV-Leitung und macht eine Umspannanlage im Stadtzentrum ueberfluessig. In einer zweijaehrigen Erprobung hat es den Praxistest bestanden. Es koennte eine Blaupause fuer die kuenftige Stromversorgung in Ballungsraeumen sein.

  7. A crítica de Alexis Philonenko ao "mal-estar" sartriano: em defesa do humanismo The criticism of Alexis Philonenko to the sartrian's malaise: in defense of the humanism

    Directory of Open Access Journals (Sweden)

    Malcom G Rodrigues

    2010-01-01

    Full Text Available O objetivo do artigo é discutir a crítica de Philonenko (1981 aos conceitos sartrianos de "má-fé" e "liberdade". Um dos pilares dessa crítica é a defesa da noção de "coerência do estilo", elemento indispensável para resguardar a autenticidade tão prezada por Sartre, segundo Philonenko. Contudo, continua este último, ao afirmar "eu não sou jamais nenhuma de minhas condutas, nenhuma de minhas atitudes", Sartre limita a liberdade por ele defendida ao horizonte de uma maliciosa dissimulação, quer dizer, da má-fé. Nós constatamos três imprecisões nessa crítica. Em primeiro lugar, a citada afirmação de Sartre foi mal interpretada. Mas, em segundo, se essa interpretação está correta, supondo que o estilo seja indispensável à autenticidade, ainda assim a liberdade sartriana não pode ser "para o mal", pois ela se caracteriza, em termos ontológicos, como o próprio ser da realidade humana "em situação", e não em termos morais, como uma propriedade dessa realidade, cristalizada por um olhar atento sobre si ou sobre o outro, e julgada como boa ou má. Por fim, queremos concluir que, numa possível conduta autêntica, a derrocada da má-fé não apenas prescinde do amparo a uma coerência do estilo como também pressupõe o reconhecimento angustiante de sua gratuidade.The aim of this paper is to discuss the Philonenko's criticism (1981 to the sartrian's concepts of "bad-faith" and "freedom". One of the pillars of this criticism is to defend the notion of "coherence of style", an indispensable element to safeguard the authenticity so relevant for Sartre, according Philonenko. However, when Sartre says "I'm not ever any of my conduct, none of my actions", limits the freedom advocated by himself on the horizon of a malicious deception, that is, the horizon of bad- faith. We found three inaccuracies in this criticism. First, the statement aforementioned of Sartre was misinterpreted. But secondly, if this interpretation is correct

  8. MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

    International Nuclear Information System (INIS)

    Byrne, Jennifer A; Sutherland, Robert L; Fazio, Anna de; O'Brien, Philippa M; Maleki, Sanaz; Hardy, Jayne R; Gloss, Brian S; Murali, Rajmohan; Scurry, James P; Fanayan, Susan; Emmanuel, Catherine; Hacker, Neville F

    2010-01-01

    The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours. MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas. MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p < 0.001; n = 124) and was an independent predictor of survival in the overall carcinoma cohort (hazard ratio (HR), 0.498; 95% confidence interval (CI), 0.34-0.728; p < 0.001; n = 221), and in serous carcinomas (HR, 0.440; 95% CI, 0.294-0.658; p < 0.001; n = 182). MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients

  9. A epilepsia nos tumores cerebrais

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    Luís Marques-Assis

    1969-03-01

    Full Text Available De 411 casos de tumores cerebrais foram estudados 86 (19,4% que apresentaram manifestações epilépticas. A epilepsia foi estudada quanto à duração, ao tipo de manifestação e à severidade, em relação à natureza e à localização dos tumores cerebrais. A análise dos resultados permitiu aos autores chegarem às seguintes conclusões: 1 a epilepsia incidiu em 19,4% dos casos; 2 o oligodendroglioma, as metástases carcinomatosas e o glioblastoma multiforme foram, pela ordem, os tumores mais epileptogênicos; 3 as áreas frontal, parietal e temporal foram, nessa ordem, as localizações mais epileptogênicas; 4 os carcinomas metastáticos predominaram nos casos com epilepsia com menos de um ano de evolução, enquanto que os astrocitomas predominaram nos casos com mais de três anos; quanto à topografia, predominou a região frontal no primeiro grupo e a temporal, no segundo; 5 nas formas mais severas de epilepsia predominaram os oligodendrogliomas e os meningeomas, quanto à natureza, e a região frontotemporal e a foice, quanto à localização; 6 os craniofaringeomas e os meduloblastomas foram os tumores que mais freqüentemente determinaram o aparecimento de convulsões puras; nesses casos, a sela túrsica e a fossa posterior foram as sedes mais freqüentes; 7 os carcinomas metastáticos e os meningeomas, quanto à natureza, e as regiões frontoparietal e parietal, quanto à localização, foram os mais freqüentemente encontrados nos casos com crises de tipo bravais-jacksoniano.

  10. Pathogenicity of Phytophthora austrocedrae on Austrocedrus chilensis and its relation with mal del ciprés in Patagonia

    Science.gov (United States)

    A. G. Greslebin; E. M. Hansen

    2010-01-01

    Field observations, isolations and pathogenicity tests were performed on Austrocedrus chilensis (Cupressaceae) trees to determine the pathogenicity of Phytophthora austrocedrae and its role in the aetiology of the cypress disease mal del ciprés (MDC) in Argentina. It was found that P. austrocedrae...

  11. La Justificación de la Presencia del Mal en el Mundo desde la Estética Agustiniana

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    David Ezequiel Téllez Maqueo

    2016-07-01

    Full Text Available La posibilidad de establecer una conciliación entre Dios como principio absoluto de bondad, y el mal presente en la realidad en sus más diversas manifestaciones (miseria, guerras, enfermedad, ignorancia, etc., ha sido una preocupación constante en la historia del pensamiento occidental. Si Dios existe, ¿cómo puede suceder que exista mal en el mundo? Para dar una respuesta racional satisfactoria se han planteado diversas respuestas. Pero Agustin de Hipona representa la primera teodicea dominante de la historia occidental, por lo que el conocimiento de su postura ante este problema es digno de interés. Para ello, el objetivo de estas líneas es triple: 1 establecer en qué consiste la solución estética de san Agustin al problema del mal, II señalar algunas de las críticas más conocidas que ha recibido en el siglo XX, y III afirmar que la solución agustiniana puede seguir siendo base de una teodicea capaz de hacer compatible la existencia de Dios y el mal en el mundo, tras la valoración de las distintas posturas críticas que ha recibido.

  12. Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy

    NARCIS (Netherlands)

    Ma, Y.; Zuidmeer, L.; Bohle, B.; Bolhaar, S. T. H.; Gadermaier, G.; Gonzalez-Mancebo, E.; Fernandez-Rivas, M.; Knulst, A. C.; Himly, M.; Asero, R.; Ebner, C.; van Ree, R.; Ferreira, F.; Breiteneder, H.; Hoffmann-Sommergruber, K.

    2006-01-01

    BACKGROUND: Profilins are ubiquitous panallergens that have been extensively characterized; yet, their clinical relevance is still unclear. OBJECTIVE: The aim of the present study was to produce recombinant apple profilin (rMal d 4) and to evaluate its allergenic activity and its potency for

  13. A Novel Bifunctional Amino Acid Racemase With Multiple Substrate Specificity, MalY From Lactobacillus sakei LT-13: Genome-Based Identification and Enzymological Characterization

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    Shiro Kato

    2018-03-01

    Full Text Available The Lactobacillus sakei strain LK-145 isolated from Moto, a starter of sake, produces potentially large amounts of three D-amino acids, D-Ala, D-Glu, and D-Asp, in a medium containing amylase-digested rice as a carbon source. The comparison of metabolic pathways deduced from the complete genome sequence of strain LK-145 to the type culture strain of Lactobacillus sakei strain LT-13 showed that the L- and D-amino acid metabolic pathways are similar between the two strains. However, a marked difference was observed in the putative cysteine/methionine metabolic pathways of strain LK-145 and LT-13. The cystathionine β-lyase homolog gene malY was annotated only in the genome of strain LT-13. Cystathionine β-lyase is an important enzyme in the cysteine/methionine metabolic pathway that catalyzes the conversion of L-cystathionine into L-homocysteine. In addition to malY, most genome-sequenced strains of L. sakei including LT-13 lacked the homologous genes encoding other putative enzymes in this pathway. Accordingly, the cysteine/methionine metabolic pathway likely does not function well in almost all strains of L. sakei. We succeeded in cloning and expressing the malY gene from strain LT-13 (Ls-malY in the cells of Escherichia coli BL21 (DE3 and characterized the enzymological properties of Ls-MalY. Spectral analysis of purified Ls-MalY showed that Ls-MalY contained a pyridoxal 5′-phosphate (PLP as a cofactor, and this observation agreed well with the prediction based on its primary structure. Ls-MalY showed amino acid racemase activity and cystathionine β-lyase activity. Ls-MalY showed amino acid racemase activities in various amino acids, such as Ala, Arg, Asn, Glu, Gln, His, Leu, Lys, Met, Ser, Thr, Trp, and Val. Mutational analysis revealed that the -amino group of Lys233 in the primary structure of Ls-MalY likely bound to PLP, and Lys233 was an essential residue for Ls-MalY to catalyze both the amino acid racemase and β-lyase reactions. In

  14. DIREITO DE EXCEÇÃO: OS RISCOS DE UM MAL NECESSÁRIO

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    Mariana Belchior Ribeiro Freire

    2010-08-01

    Full Text Available O presente trabalho tem como escopo analisar o estado de exceção no seu liame entre a manutenção do status quo ante e o salto para a revolução. Sob a óptica dos pensamentos de renomados filósofos (Jean Bodin, Thomas Hobbes, Rosseau, Hans Kelsen e Carl Schmitt, procuramos analisar os benefícios e os riscos da instituição do estado de exceção, tendo em vista que se pode considerar este um mal necessário. O estado de exceção é um avanço nas democracias contemporâneas, como observaremos a sua previsão importa uma segurança à sociedade de que é possível mudar preservando alguns direitos constitucionais.

  15. Uruguay mining inventory results of the Mal Abrigo aerial photography chemical prospect ion

    International Nuclear Information System (INIS)

    Zeegers, H.; Artignan, D.; Vairon, P.

    1982-01-01

    This report presents the results of the chemical prospecting strategic multielemental carried out, of the mining Inventory framework from the Uruguay aerial photography Mal Abrigo (sector M 25, area 82). The covered surface is of 660 km with a total of 753 samples, corresponding to an approximate sampling density of 1.14 samples for krri2; in parallel pH measures and radioactivity were made. The samples were analyzed in the laboratories of the BRGM (Orleans), for 22 elements for Spectrometry of Emission Captures. The geochemical answer in connection with the litology was good. Sixteen anomalies, little contrasted has been retained in what concerns to the elements Pb, Zn, Cu, Ace, Ag, and W; eight of those which are constituted for regrouping points. The main purpose has been to search ultramafic rocs in Cerro Chato -Durazno province.

  16. SmartMal: A Service-Oriented Behavioral Malware Detection Framework for Mobile Devices

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    Chao Wang

    2014-01-01

    Full Text Available This paper presents SmartMal—a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server’s main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users’ regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices.

  17. Mal de Debarquement Syndrome: A Rare Entity—A Case Report and Review of the Literature

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    Veronica Nwagwu

    2015-01-01

    Full Text Available Mal de Debarquement Syndrome (MDS is a rare, understudied, underdiagnosed, and self-limiting condition. Etiology and incidence are unknown. It is characterized by abnormal sensation of motion/balance reported after travel by air, land, and sea; being reexposed to motion/activity relieves it. Symptoms may last from minutes to years. Workup though required reveals no findings; it is a diagnosis of exclusion. While no efficacious treatment exists, amitriptyline and benzodiazepines as well as supportive therapy have proved to be useful. We have described a 40-year-old Caucasian female who presented for the evaluation of persistent rocking and swaying sensation after a ship cruise which lasted for one week. Patient was treated with benzodiazepines after extensive workup and is now stable. A high index of suspicion is required to make a diagnosis.

  18. malERA: An updated research agenda for malaria elimination and eradication.

    Science.gov (United States)

    Rabinovich, Regina N; Drakeley, Chris; Djimde, Abdoulaye A; Hall, B Fenton; Hay, Simon I; Hemingway, Janet; Kaslow, David C; Noor, Abdisalan; Okumu, Fredros; Steketee, Richard; Tanner, Marcel; Wells, Timothy N C; Whittaker, Maxine A; Winzeler, Elizabeth A; Wirth, Dyann F; Whitfield, Kate; Alonso, Pedro L

    2017-11-01

    Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated. However, the need for innovation to achieve these goals, sustain elimination, and free the world of malaria is greater than ever. Over 180 experts across multiple disciplines are engaged in the Malaria Eradication Research Agenda (malERA) Refresh process to address problems that need to be solved. The result is a research and development agenda to accelerate malaria elimination and, in the longer term, transform the malaria community's ability to eradicate it globally.

  19. malERA: An updated research agenda for malaria elimination and eradication.

    Directory of Open Access Journals (Sweden)

    Regina N Rabinovich

    2017-11-01

    Full Text Available Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated. However, the need for innovation to achieve these goals, sustain elimination, and free the world of malaria is greater than ever. Over 180 experts across multiple disciplines are engaged in the Malaria Eradication Research Agenda (malERA Refresh process to address problems that need to be solved. The result is a research and development agenda to accelerate malaria elimination and, in the longer term, transform the malaria community's ability to eradicate it globally.

  20. ACCUMULATION OF POLYHYDROXYALKANOIC ACIDS BY AZOTOBACTER CHROOCOCCUM MAL-201 FROM ORGANIC WASTE

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    Soma Pal Saha

    2013-08-01

    Full Text Available Azotobacter chroococcum MAL-201 (MTCC 3853, a free-living nitrogen-fixing bacterium accumulated intracellular poly(3-hydroxybutyric acid [P(3HB] accounting 69% of cell dry weight (CDW when grown in nitrogrn-free Stockdale medium containing 2% (w/v glucose. It also produced copolymer of poly(3-hydroxybutyrate co-3-hydroxyvalerate [P(3HB-co-3HV] using glucose as primary carbon source and valerate cas cosubstrate. To make the polymer production cost effective four types of waste material of different origin were tested for growth and polymer production. Stockdale medium supplemented with 1% (w/v waste materials failed to yield good growth and polymer accumulation. Two–step cultivation was adopted for better growth and enhanced polymer accumulation. The candy factory waste was most suitable for synthesis of P(3HB accounting 17.8 and 40.58% using single and two-step cultivation conditions respectively. Wastes of domestic and poultry origin produced P(3HB-co-3HV with 3HV content 28.8 and 21.5 mol% respectively in two-step cultivation. Increase concentration of these wastes resulted in further upliftment of 3HV content of polymer with reduced growth and polymer accumulation. However, at optimum incubation the strain MAL-201 cells accumulated P(3HB 48.5% of CDW (at 40h from candy factory waste and P(3HB-co-3HV 24.75 % of CDW with 3HV 34.65 mol % from domestic waste. Intrinsic viscosity, molecular weight and thermal degradation of the polymers accumulated in the cells grown in glucose, glucose with valerate and glucose with waste were compared.

  1. MAL Overexpression Leads to Disturbed Expression of Genes That Influence Cytoskeletal Organization and Differentiation of Schwann Cells

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    Daniela Schmid

    2014-09-01

    Full Text Available In the developing peripheral nervous system, a coordinated reciprocal signaling between Schwann cells and axons is crucial for accurate myelination. The myelin and lymphocyte protein MAL is a component of lipid rafts that is important for targeting proteins and lipids to distinct domains. MAL overexpression impedes peripheral myelinogenesis, which is evident by a delayed onset of myelination and reduced expression of the myelin protein zero (Mpz/P0 and the low-affinity neurotrophin receptor p75NTR . This study shows that MAL overexpression leads to a significant reduction of Mpz and p75NTR expression in primary mouse Schwann cell cultures, which was already evident before differentiation, implicating an effect of MAL in early Schwann cell development. Their transcription was robustly reduced, despite normal expression of essential transcription factors and receptors. Further, the cAMP response element-binding protein (CREB and phosphoinositide 3-kinase signaling pathways important for Schwann cell differentiation were correctly induced, highlighting that other so far unknown rate limiting factors do exist. We identified novel genes expressed by Schwann cells in a MAL-dependent manner in vivo and in vitro. A number of those, including S100a4, RhoU and Krt23, are implicated in cytoskeletal organization and plasma membrane dynamics. We showed that S100a4 is predominantly expressed by nonmyelinating Schwann cells, whereas RhoU was localized within myelin membranes, and Krt23 was detected in nonmyelinating as well as in myelinating Schwann cells. Their differential expression during early peripheral nerve development further underlines their possible role in influencing Schwann cell differentiation and myelination.

  2. El mal de ojo y su relación con el marasmo y kwashiorkor: El caso de las madres de Turbo, Antioquia, Colombia Mal de ojo and its relationship with marasm and kwashiorkor: the Turbo mother’s case

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    Gildardo Uribe Gil

    2007-03-01

    Full Text Available Objetivo: Describir las percepciones y prácticas socio-culturales de las madres frente al proceso de desnutrición aguda grave de los niños: marasmo y kwashiorkor. Metodología: Etnografía descriptiva. Se realizaron 20 entrevistas semiestructuradas, 2 entrevistas grupales y observación en los hogares y en el hospital. El análisis se realizó manualmente. Resultados: Las madres perciben la desnutrición aguda grave como una consecuencia del mal de ojo, el cual afecta a los niños menores de 7 años. El mal de ojo se clasifica como "ojo secador" y "ojo de la calle". Para las madres, el ojo secador enmagrece totalmente a los niños, lo cual podríamos asimilar al marasmo. No es claro si el ojo de la calle conlleva al kwashiorkor, pero es claro que el kwashirkor es causado por el mal de ojo. Los médicos tradicionales, como los rezanderos, ocupan un lugar importante en el tratamiento de las enfermedades de filiación cultural. Conclusiones: En el modelo biomédico no existen ni el mal de ojo ni la desnutrición como enfermedad. La desnutrición se conceptúa como estado y finalmente se objetiviza en cifras estadísticas, lo cual dificulta la atención integral de los niños. El estudio devela un mundo desconocido por el sistema biomédico, y un mundo de prácticas culturales frente al proceso de desnutrición, que adecuadamente valoradas permitirían mejorar la atención integral y evitar la muerte infantil por desnutrición aguda grave o por el mal de ojo.Objective: To describe perceptions and socio- cultural practices by the mothers facing severe malnutrition in children: Marasm and Kwashiorkor. Methodology: Descriptive ethnography. Twenty semi-structured interviews and two tribal ones were carried. Homes and hospitalized children were observed. Analysis was manually performed. Results: Mother perceives severe malnutrition like "mal de ojo" consequence afflicting children under seven. Mal de ojo is classified as "drying-eye" or as "street

  3. Malária no Estado do Amapá, Brasil, de 1970 a 2003: trajetória e controle Malaria in Amapá State, Brazil, 1970-2003: background and control

    Directory of Open Access Journals (Sweden)

    Rosilene Ferreira Cardoso

    2007-06-01

    Full Text Available O presente estudo tem por objetivo dimensionar a ocorrência de malária no Estado do Amapá, Brasil, no período de 1970 a 2003. Com dados de lâminas positivas, obtidos junto a agências de informações em saúde, foi construída uma série temporal de índice parasitário anual (IPA, por mil habitantes, considerando as informações de população obtidas junto ao Instituto Brasileiro de Geografia e Estatística. No contexto de um intenso incremento populacional, associado ao desenvolvimento regional, os resultados evidenciaram um aumento no período - não linear - dos valores de IPA, que passaram de 15,1‰, em 1970, para 74‰ no ano 2000. No reverso desse movimento, em meio aos esforços de controle da doença, observa-se uma queda desses valores a partir de 2001, que alcança a ordem prevista de 50% em 2002. Acompanhando o movimento de incidência parasitária anual da malária na Amazônia, esses resultados apontaram para o aumento dos valores do IPA no período de 1970 a 2000, observando-se uma redução nos anos subseqüentes, cumprindo com as metas estabelecidas sob o programa vigente de controle da malária no Estado.The present study aims to describe malaria occurrence from 1970 to 2003 in the State of Amapá, Brazil. With positive films obtained from health agencies, temporal series on the annual parasite incidence - API (per 1,000 inhabitants were elaborated, taking into account population data available from the Brazilian Institute of Geography and Statistics. The results showed an increase in API values, although non-linear, related to the rapid population growth associated with regional economic and social development during the period, ranging from 15.1‰ in 1970 to 74.0‰ in 2000. Reversing this trend, a decrease appeared from 2001 onward, reaching a reduction of 50% in 2002. The results showed an increase in API values from 1970 to 2000, consistent with the incidence profile for malaria occurrence in the Amazon. A

  4. MGE-derived nNOS+ interneurons promote fear acquisition in nNOS-/- mice.

    Science.gov (United States)

    Zhang, Lin; Yuan, Hong-Jin; Cao, Bo; Kong, Cheng-Cheng; Yuan, Fang; Li, Jun; Ni, Huan-Yu; Wu, Hai-Yin; Chang, Lei; Liu, Yan; Luo, Chun-Xia

    2017-12-02

    Neuronal nitric oxide synthase (nNOS) 1 , mainly responsible for NO release in central nervous system (CNS) 2 , plays a significant role in multiple physiological functions. However, the function of nNOS + interneurons in fear learning has not been much explored. Here we focused on the medial ganglionic eminences (MGE) 3 -derived nNOS + interneurons in fear learning. To determine the origin of nNOS + interneurons, we cultured neurons in vitro from MGE, cortex, lateral ganglionic eminence (LGE) 4 , caudal ganglionic eminences (CGE) 5 and preoptic area (POA) 6 . The results showed that MGE contained the most abundant precursors of nNOS + interneurons. Moreover, donor cells from E12.5 embryos demonstrated the highest positive rate of nNOS + interneurons compared with other embryonic periods (E11.5, E12, E13, E13.5 and E14). Additionally, these cells from E12.5 embryos showed long axonal and abundant dendritic arbors after 10 days culture, indicating the capability to disperse and integrate in host neural circuits after transplantation. To investigate the role of MGE-derived nNOS + interneurons in fear learning, donor MGE cells were transplanted into dentate gyrus (DG) 7 of nNOS knock-out (nNOS -/- ) or wild-type mice. Results showed that the transplantation of MGE cells promoted the acquisition of nNOS -/- but not the wild-type mice, suggesting the importance of nNOS + neurons in fear acquisition. Moreover, we transplanted MGE cells from nNOS -/- mice or wild-type mice into DG of the nNOS -/- mice and found that only MGE cells from wild-type mice but not the nNOS -/- mice rescued the deficit in acquisition of the nNOS -/- mice, further confirming the positive role of nNOS + neurons in fear learning. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Malária grave importada: relato de caso Severe imported malaria: case report

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    Alessandra Alves

    2007-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A malária ainda representa um problema de saúde global. A forma grave da doença é causada principalmente por P. falciparum e pode cursar com complicações cerebrais, renais, pulmonares, hematológicas, circulatórias e hepáticas. O objetivo deste estudo foi relatar um caso de paciente portador de malária grave importada. RELATO DO CASO: Paciente do sexo masculino, 30 anos, pardo, filipino, marinheiro, proveniente de embarcação vinda da Nigéria, com história de dor abdominal no hipocôndrio direito, icterícia, febre e rebaixamento do nível de consciência. Os exames laboratoriais de admissão mostraram hiperbilirrubinemia de 50 mg/dL, acidose metabólica grave, trombocitopenia, creatinina de 5,6 mg/dL, leucocitose com desvio até metamielócitos. O escore APACHE II foi de 37, com risco de óbito de 88%. Durante a internação foi diagnosticada malária por P. falciparum pelo teste de gota espessa. Mesmo com tratamento antimalárico adequado, o paciente evoluiu com insuficiência renal aguda necessitando de hemodiálise e síndrome de angústia respiratória aguda (SARA, necessitando de ventilação mecânica (VM, choque refratário tratado com aminas vasoativas, além de quadro hematológico, configurando um caso grave de disfunção de múltiplos de órgãos. Ainda apresentou pneumonia associada à VM e sepse relacionada ao uso de cateteres. Após a alta hospitalar, o paciente não apresentou seqüelas cerebral, pulmonar ou renal. CONCLUSÕES: Dos critérios definidores de malária grave descritos na literatura, o paciente preenchia: insuficiência renal aguda, síndrome da angústia respiratória aguda (SARA, acidose metabólica, alteração do nível de consciência, hemoglobinúria macroscópica, hiperparasitemia e hiperbilirrubinemia, que se relaciona a uma mortalidade maior que 10%, na dependência do tratamento precoce e dos recursos disponíveis. A malária grave exige diagnóstico e tratamento

  6. Le problème du mal dans le Guide des Perplexes et son arrière-plan talmudique

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    Costa, José

    2010-12-01

    Full Text Available At first sight, the question of evil is regarded in the Guide for the Perplexed in a paradoxical manner. Thus, in Guide I, 2, Maimonides examines the notions of good and evil as subjective evaluations possessing neither the rigour not the exactness of the notions of true and false. However, the question of evil occupies an essential place in the Guide, as various modern authors have shown. This question is important to Maimonides because he is, in this respect, the heir of the rabbinic tradition and his conception of evil is largely based on an interaction with the Talmudic and Midrašic texts. Therefore, we would like to review thirty-nine rabbinic ‘quotes’ which appear in chapters 8 to 24 in the third part of the Guide and deal with the origin of evil, the meaning of suffering and the evil inclination. Maimonides reappropriates the midrašim that are susceptible of being in agreement with his rationalist positions and also quotes some rabbinic traditions that are too close to mu ͑tazilism, undoubtedly aware of the more profound resemblance that exists between the rabbinic and mu ͑tazilite doctrines of evil and retribution.A primera vista, el problema del mal es abordado en la Guía de Perplejos de manera paradójica. Para Maimónides, las nociones de bien y mal son subjetivas y no resultan ni rigorosas ni exactas, a la inversa de las nociones de verdad y falsedad (Guía I, 2. Sin embargo, el problema del mal es muy importante en la Guía, como lo demostraran varios autores. Maimónides es el heredero de la tradición rabínica y existe en la Guía una interacción entre la filosofia de Maimónides y los textos talmúdicos y midrásicos. Es particularmente el caso de las treinta y nueve citas rabínicas de la Guía II, 8-24, que tratan del origen del mal, del significado del sufrimiento y de la inclinación al mal. Maimónides cita los midrašim que concuerdan con sus posiciones racionalistas y evoca también algunas tradiciones rab

  7. Necropsia e mortalidade por causa mal definida no Estado de São Paulo, Brasil Autopsy and ill-defined cause of death in the state of São Paulo, Brazil

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    Mauro Abrahão Rozman

    2006-11-01

    Full Text Available OBJETIVO: Investigar a proporção de mortes por causa mal definida no Estado de São Paulo entre 1980 e 2002, considerando a influência da realização de necropsia nessa proporção. MÉTODO: O número de óbitos foi obtido do Ministério da Saúde. Dividiu-se o Estado de São Paulo em três áreas: 1 municípios com serviço de verificação de óbitos (SVO, que pode realizar necropsias; 2 municípios sem SVO; e 3 Baixada Santista, região onde houve um aumento marcante na proporção de mortes por causa mal definida entre 1980 e 1995. O impacto das necropsias na proporção de óbitos por causa mal definida foi medido com base na classificação da causa de óbito pelo primeiro médico avaliador (aquele que encaminhou o caso para o SVO para necropsia ou que preencheu a declaração de óbito sem encaminhar o caso. Os óbitos por causas externas foram excluídos por ter necropsia obrigatória. Foram avaliadas as proporções 1 de casos classificados como de causa mal definida pelo primeiro avaliador; 2 de necropsias no total de óbitos excluindo causas externas; e 3 de óbitos com causa esclarecida por necropsia entre os classificados como de causa mal definida pelo primeiro avaliador. RESULTADOS: A proporção de óbitos classificados como de causa mal definida pelo primeiro avaliador aumentou entre 1980 e 2002 em todas as áreas: nos municípios com SVO, nos municípios sem SVO e na Baixada Santista. Para o Estado de São Paulo como um todo, o aumento foi de quase 30% no período de 1980 a 2002. Para o período de 1998 a 2002, a proporção média de necropsias no total de óbitos excluindo causas externas foi de 21,2, 6,4 e 2,6%, respectivamente, nas áreas com e sem SVO e na Baixada Santista. Entre 1998 e 2002, a proporção de óbitos com causa mal definida esclarecidos pela necropsia foi de 92,9 nas áreas com SVO, 32,5 nas áreas sem SVO e 10,7% na Baixada Santista. CONCLUSÕES: A realização de necropsias explica a diferença na

  8. Neuronal NOS localises to human airway cilia.

    Science.gov (United States)

    Jackson, Claire L; Lucas, Jane S; Walker, Woolf T; Owen, Holly; Premadeva, Irnthu; Lackie, Peter M

    2015-01-30

    Airway NO synthase (NOS) isoenzymes are responsible for rapid and localised nitric oxide (NO) production and are expressed in airway epithelium. We sought to determine the localisation of neuronal NOS (nNOS) in airway epithelium due to the paucity of evidence. Sections of healthy human bronchial tissue in glycol methacrylate resin and human nasal polyps in paraffin wax were immunohistochemically labelled and reproducibly demonstrated nNOS immunoreactivity, particularly at the proximal portion of cilia; this immunoreactivity was blocked by a specific nNOS peptide fragment. Healthy human epithelial cells differentiated at an air-liquid interface (ALI) confirmed the presence of all three NOS isoenzymes by immunofluorescence labelling. Only nNOS immunoreactivity was specific to the ciliary axonemeand co-localised with the cilia marker β-tubulin in the proximal part of the ciliary axoneme. We report a novel localisation of nNOS at the proximal portion of cilia in airway epithelium and conclude that its independent and local regulation of NO levels is crucial for normal cilia function. Copyright © 2014 Elsevier Inc. All rights reserved.

  9. A importância do perfil clínico-laboratorial no diagnóstico diferencial entre malária e hepatite aguda viral Importance of clinical and laboratory profiles for the differential diagnosis of malaria and acute viral hepatitis

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    Cacyane Naiff do Amaral

    2003-10-01

    Full Text Available OBJETIVOS: Destacar o perfil clínico-laboratorial de malária e hepatite aguda viral em dois grupos de crianças, ressaltando semelhanças e diferenças entre os dois quadros; subsidiar o aumento da sensibilidade clínica de presunção diagnóstica precoce de malária na infância. MÉTODOS: Foram estudados dois grupos de 30 crianças, de dois a dez anos de idade, portadoras de primo infecção malárica ou hepatite viral aguda, confirmados pela pesquisa de plasmódio e pesquisa de marcadores virais de hepatite A e B. As crianças foram submetidas às seguintes avaliações no primeiro dia de atendimento: hemograma, contagem de plaquetas, dosagem de enzimas hepáticas, uréia, creatinina e bilirrubinas. Os achados clínicos e laboratoriais foram descritos e comparados entre os dois grupos. Proporções de indivíduos com exames físicos alterados foram comparadas nos dois grupos, pelo teste exato de Fisher. RESULTADOS: A apresentação clínica inicial da doença foi semelhante em todos os pacientes: febre, cefaléia, sintomas digestivos e colúria. Metade dos portadores de malária não apresentou a tríade clássica, apesar de todos terem apresentado febre moderada ou alta, ao contrário dos portadores de hepatite. Na avaliação laboratorial, os portadores de malária apresentaram mais anemia e plaquetopenia quando comparados aos portadores de hepatite. Foram marcantes, nos portadores de hepatite, as elevações de bilirrubinas e enzimas hepáticas. CONCLUSÕES: A propedêutica detalhada e a avaliação criteriosa dos exames laboratoriais inespecíficos constituem peças fundamentais para a diferenciação clínica entre os dois diagnósticos, reforçando a identificação precoce do parasita e, conseqüentemente, o tratamento rápido de malária em crianças.OBJECTIVE: To establish clinical and diagnostic findings of malaria and acute viral hepatitis in children, stressing similarities and differences, so as to enhance the sensitivity of

  10. Epilepsia"Petit Mal" aspectos clínicos, eletrencefalográficos e evolutivos

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    Paulo Pinto Pupo

    1961-01-01

    Full Text Available In the past few years somewhat new yet often differing points of view have been affirmed refering to Petit Mal epilepsy, with regard to its clinical, eletrencephalographic and evolutive aspects. The classical concept of PM epilepsy as established by Lennox and Gibbs, with its well defined clinical and EEGraphic characteristics is continually being modified with new research work on clinical and EEGraphic aspects. Numerous clinical cases have been published whose evolution clashes with that classically described and likewise numerous are those cases where the EEG shows signs of focal electric activity besides spike and wave dis-rythmia. Cases have been known where surgical exerese on the focus causes temporary desappearance of the spike and wave disrythmia. The present concept now holding sway is that PM epilepsy is a kind of reaction of infantile encephalon to diverse harmful causes. From this it will be seen we are very far from the concept that PM epilepsy is a pure form of idiopathic epilepsy. For these reasons we decided to re-examine those cases observed between 1950 and 1960. With this in mind we chose 141 PM epilepsy cases, from among over 23000 epileptics, all examined under a standard criterion by a small group of senior assistants. All cases suspected of Psm epilepsy were excluded. The analysis of this group of patients was compared to that of another group with GM as well as PM seizures (104 patients; in 52 of these cases, studies were made concerning the evolutive, clinical and EEGra-phic aspects. METHOD: Clinical criterion was used for selection of the cases. The results of the analysis from the clinical and EEGraphic point of view were exhibited in demonstrative graphs. From the clinical point of view we strove to find out positive hereditary elements, organic cerebral injury factor (intellectual deficit, mood and behaviour disturbances, neurologic or somatic signs, as well as other development anomalies, the presence of febrile

  11. Hypothesis: The Vestibular and Cerebellar Basis of the Mal de Debarquement Syndrome

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    Bernard Cohen

    2018-02-01

    Full Text Available The Mal de Debarquement syndrome (MdDS generally follows sea voyages, but it can occur after turbulent flights or spontaneously. The primary features are objective or perceived continuous rocking, swaying, and/or bobbing at 0.2 Hz after sea voyages or 0.3 Hz after flights. The oscillations can continue for months or years and are immensely disturbing. Associated symptoms appear to be secondary to the incessant sensation of movement. We previously suggested that the illness can be attributed to maladaptation of the velocity storage integrator in the vestibular system, but the actual neural mechanisms driving the MdDS are unknown. Here, based on experiments in subhuman primates, we propose a series of postulates through which the MdDS is generated: (1 The MdDS is produced in the velocity storage integrator by activation of vestibular-only (VO neurons on either side of the brainstem that are oscillating back and forth at 0.2 or 0.3 Hz. (2 The groups of VO neurons are driven by signals that originate in Purkinje cells in the cerebellar nodulus. (3 Prolonged exposure to roll, either on the sea or in the air, conditions the roll-related neurons in the nodulus. (4 The prolonged exposure causes a shift of the pitch orientation vector from its original position aligned with gravity to a position tilted in roll. (5 Successful treatment involves exposure to a full-field optokinetic stimulus rotating around the spatial vertical countering the direction of the vestibular imbalance. This is done while rolling the head at the frequency of the perceived rocking, swaying, or bobbing. We also note experiments that could be used to verify these postulates, as well as considering potential flaws in the logic. Important unanswered questions: (1 Why does the MdDS predominantly affect women? (2 What aspect of roll causes the prolongation of the tilted orientation vector, and why is it so prolonged in some individuals? (3 What produces the increase in symptoms of

  12. Migrações internas e malária urbana - Bahia, Brasil Internal migration and urban malaria - Bahia, Brazil

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    Sebastião Loureiro de Souza

    1986-10-01

    Full Text Available Estuda-se as características sócio-econômicas dos indivíduos acometidos pela malária, em 1983, na área urbana de Camaçari - Bahia, Brasil, com destaque para os subgrupos migrantes e não migrantes. As condições de vida precárias de ambos os subgrupos são apontadas como os determinantes do surto de malária desencadeado no local.It is proposed to study the socio-economic characteristics of individuals who were infected with malaria in the urban area of Camaçari, Bahia, Brazil, in 1983. Special emphasis being given to the subgroups of migrants and nonmigrants. The precarious living conditions of both subgroups are identified as determinative of the malaria outbreak which occurred there.

  13. Contaminación acústica en la zona 3 de la ciudad de Querétaro: comparación de los niveles de ruido reales y los apreciados por los habitantes

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    Ivan Peñaloza Pineda

    2016-01-01

    Full Text Available En este artículo se describen los daños ocasionados la contaminación acústica en distintos niveles, expuestos en diversos estudios científicos; se muestran mediciones de decibeles in situ, así como los resultados de un estudio exploratorio que expone la percepción respecto a la contaminación acústica de 168 habitantes de una zona determinada de la ciudad de Querétaro, con el objetivo de encontrar el grado de afectación percibida para determinar si hay concordancia al respecto. El presente artículo forma parte de una investigación encaminada al desarrollo de un producto orientado a la disminución del ruido en las viviendas. Nuestros hallazgos indican que, aunque cerca de 60% de los encuestados encuentra el ruido de la zona como “elevado”, e identifica los vehículos y las motocicletas como la fuente de ruido más molesta, al mismo tiempo no son conscientes de las afectaciones en el desempeño de sus actividades como consecuencia de los niveles de contaminación acústica en la zona.

  14. Analytical Characterization of the Hydrolysis of Barley Malt Macromolecules During Enzymatic Degradation Over Time Using AF4/MALS/RI.

    Science.gov (United States)

    Rübsam, Heinrich; Becker, Thomas; Gastl, Martina

    2017-06-01

    The changes on the molecular weight distribution (MWD) and particle size distribution (PSD) during hydrolysis of barley malt in isothermal mashing procedures were determined using asymmetrical flow field flow fractionation coupled to multiangle laser light scattering and refractive index (AF4/MALS/RI). Mash/trials were focused on amylolytic starch degradation. Therefore, temperatures (65, 70, and 75 °C) were selected according to α- and β-amylases range of activity. Samples were produced by triplicate, tracking amylolytic processes over time periods from 10 to 90 min in each mash/trial. AF4/MALS/RI analysis demonstrated significant differences on the values of the MWD and PSD according to the temperature/time profile used. At mashing times over 30 min at a temperature of 65 °C, when α- and β-amylase are both active, the decrease over time of the MWD and PSD was significantly higher (P < 0.005) than at 70 °C when mainly α-amylase is active. At 75 °C, also the activity of α-amylase decreased and the MWD and PSD were significantly lower (P < 0.005) than at 70 or 65 °C at any time of the procedure. The MWD and PSD of beer components influence beer palate fullness, thus AF4/ MALS/RI would be a powerful tool for breweries to adapt their technological processes to obtain beers with particular sensorial attributes. © 2017 Institute of Food Technologists®.

  15. La naturaleza del mal en el pensamiento de Hannah Arendt | The nature of evil in Hannah Arendt’s thinking

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    María Cristina Hermida del Llano

    2016-12-01

    Full Text Available RESUMEN. La cuestión del mal ocupa un lugar central en el pensamiento de Hannah Arendt al constituir un concepto transversal que recorre todos sus trenes de pensamiento. Se somete a análisis la “naturaleza del mal” a través del estudio de su obra y de su propia experiencia vital, especialmente al cubrir el juicio de Eichmann en Jerusalén, donde ella afirmaría que éste representaba “la banalidad del mal”. Se trata de averiguar si en su particular concepción del mal influyó Voltaire, por qué surge el mal, por qué se manifiesta de forma permanente en la historia y si puede ser destruido   ABSTRACT. The topic of evil has a central place in Hannah Arendt’s thinking as it lies at the core of all her trains of thought. We analyze the “nature of evil” in Hannah Arendt’s philosophy through the study of her work and of her life experience, especially when she covered the trial of Eichmann in Jerusalem where she pointed out that Eichmann represented “the banality of evil”. Our goal in this contribution is to understand whether the philosophy of Voltaire could have influenced Arendt’s conception of evil, why it arises, why it persists throughout history, and whether it can be destroyed

  16. Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy.

    Science.gov (United States)

    Kinaciyan, T; Nagl, B; Faustmann, S; Kopp, S; Wolkersdorfer, M; Bohle, B

    2016-02-01

    It is still unclear whether allergen-specific immunotherapy (AIT) with birch pollen improves birch pollen-related food allergy. One reason for this may be the lack of standardized tests to assess clinical reactions to birch pollen-related foods, for example apple. We tested the applicability of recombinant (r) Mal d 1, the Bet v 1-homolog in apple, for oral challenge tests. Increasing concentrations of rMal d 1 in 0.9% NaCl were sublingually administered to 72 birch pollen-allergic patients with apple allergy. The dose of 1.6 μg induced oral allergy syndromes in 26.4%, 3.2 μg in 15.3%, 6.3 μg in 27.8%, 12.5 μg in 8.3%, 25 μg in 11.1%, and 50 μg in 4.2% of the patients. No severe reactions occurred. None of the patients reacted to 0.9% NaCl alone. Sublingual administration of 50 μg of rMal d 1 induced no reactions in three nonallergic individuals. Our approach allows straight forward, dose-defined sublingual challenge tests in a high number of birch pollen-allergic patients that inter alia can be applied to evaluate the therapeutic efficacy of birch pollen AIT on birch pollen-related food allergy. © 2015 The Authors. Allergy Published by John Wiley & Sons Ltd.

  17. Albertet, “En amor trob tantz de mals seignoratges” (BdT 16.13

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    Francesca Sanguineti

    2008-12-01

    Full Text Available The article provides a commentary and a new critical edition of Albertet’s poem “En amor trob tantz de mals seignoratges”, in which the troubadour praises some of the most courtly ladies of his time. The poem can be linked to the genre of the collective eulogy, where the enumerated ladies are praised essentially for political reasons, since the commendation is clearly addressed to the men hidden behind them: famous specimena of this genre are the ‘tournoiements des dames’ by Huon d’Oisy and Richard de Semilli and Raimbaut de Vaqueiras’ “Carros” (BdT 392.32. Albertet’s song starts with a misogynic tone, since the poet declares that celebrating or loving ladies is worthless, given their immoral behaviour, and with a polemic against the strict rules of courtly love. This misogyny, as is further discovered, is a rhetorical device to praise women as well as a tool to renew the genre of the love song from a thematic point of view.

  18. (Mal)nutrition and the new epidemiological trend in a context of development and inequalities.

    Science.gov (United States)

    Souza, Nathália Paula de; Lira, Pedro Israel Cabral de; Fontbonne, Annick; Pinto, Fernanda Cristina de Lima; Cesse, Eduarda Ângela Pessoa

    2017-07-01

    The current context of intense social, economic and political transformations has contributed to changes in the health profile of the population and generated discussions about the impact of these changes on the reorganization of society. At the present moment, the increase in non-communicable illnesses and diseases raises major concerns about the paradox of malnutrition and obesity. Based on an in-depth reading and interpretation of texts, documents and databases, this article discusses issues related to nutrition, considering the dimensions of shortages and excesses, the evolution of nutrition over time, and the connection with the new epidemiological trend. We begin with a conceptual characterization, the historical background and the anthropological connections with the guiding theme of the article. We then describe the prevalence, distribution and secular trend of malnutrition and obesity, as well as the temporal relationship with the new epidemiological trend in Brazil within a context of development and inequalities. Finally, we reflect on the issue of (mal)nutrition in post-modernity, the new interests at stake in the health-disease process, as well as international experiences and strategies of partnerships designed to overcome these problems. We conclude by discussing some current advances and challenges in relation to the complexity and speed of contemporary changes.

  19. Decodificando la esencia del mal, o del terror a la muerte del hijo

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    Maximiliano Korstanje

    2011-01-01

    Full Text Available Durante muchos años filósofos y teólogos se han cuestionado sobre la cuestión de la caída. Es innumerable la bibliografía sobre el tema como así también las propias dudas sobre la omnipresencia y sabiduría de un Dios que implícitamente o no permite la presencia del pecado por medio de su propia creación. El mito fundador de querubín Lucifer no sólo simboliza la relación entre el hombre y la traición sino también el amor filial entre el padre y su creación las cuales concilian la negación cultural de la muerte de la progenie o generaciones más jóvenes. Utilizando la teoría antropológica de los dones de M. Mauss, el presente trabajo teórico intentará explicar el origen mítico del mal dentro de la tradición judeo-cristiana como una de las elaboraciones más temidas, la muerte del hijo.

  20. Quema de libros y antitotalitarismo. Manuel Rivas Los libros arden mal y Ray Bradbury Fahrenheit 451

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    Mechthild Albert

    2015-07-01

    Full Text Available El presente artículo se propone comparar dos novelas cuyo común denominador es el compromiso antitotalitario con motivo de la quema de libros considerada como el culmen de la barbarie anticultural, a saber Los libros arden mal (2006 de Manuel Rivas y Fahrenheit 451 (1953 de Ray Bradbury. Partiendo de las reflexiones de Fernando Rodríguez de la Flor en torno al biblioclasmo (2004, el paralelo se centra en los siguientes aspectos: la descripción zoo- y antropomorfizada de los libros en llamas; el biblioclasmo como expresión del totalitarismo, denotando asimismo una relación ambivalente y dialéctica entre cultura y barbarie; los movimientos subversivos dedicados a mantener el culto al libro y la tradición filosófico-literaria; la intertextualidad y el papel destacado de la Biblia en cuanto Libro de los libros. En conclusión se podrá constatar que, a pesar de numerosos puntos en común, en particular su compromiso antitotalitario, ambos autores se distinguen en concreto por su orientación política y el enfoque de su crítica cultural

  1. El mal en las palabras: El hombre tempestad Evil in Words: El hombre tempestad

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    Ángela Uribe Botero

    2009-06-01

    Full Text Available En este trabajo se muestra cómo es posible que el mal pueda estar contenido en cierta forma de hablar. En términos de J. L. Austin, y de la mano de Hannah Arendt, a la luz de un ejemplo tomado de la historia colombiana, se ilustra la fuerza ilocucionaria de ciertas expresiones. El ejemplo está contenido en uno de los discursos más célebres del expresidente colombiano Laureano Gómez Castro. El texto concluye mostrando cómo, con los enunciados que Gómez emite, antes que cumplir las promesas que hace en su discurso o describir una serie de cosas, miente y en tanto hace esto, cambia el mundo en la forma de actuar sobre él con maldad.This text shows how evil can be contained in certain way of speaking. In terms of J. L. Austin, and considering Hannah Arendt, with the help of an example taken from recent Colombian history, it illustrates the ilocucionary force of certain expressions. The example is found in one of the most important speeches of former president Laureano Gómez Castro. The text concludes by showing how, Gómez, rather than maintaining promises that he makes in his speech or describing a series of things, lies, and in so doing, changes the world through his way of evilly acting above it.

  2. Santa Clara de Nanay: the MAL-ED cohort in Peru.

    Science.gov (United States)

    Yori, Pablo Peñataro; Lee, Gwenyth; Olórtegui, Maribel Paredes; Chávez, César Banda; Flores, Julian Torres; Vasquez, Angel Orbe; Burga, Rosa; Pinedo, Silvia Rengifo; Asayag, César Ramal; Black, Robert E; Caulfield, Laura E; Kosek, Margaret

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study communities in Peru are located in Loreto province, in a rural area 15 km from the city of Iquitos. This riverine population of approximately 5000 individuals is fairly representative of Loreto. The province lags behind the rest of the country in access to water and sanitation, per capita income, and key health indicators including infant mortality (43.0 vs 16.0 per 1000 nationwide) and under-5 mortality (60.6 vs 21.0 per 1000). Total fertility rates are higher than elsewhere in the country (4.3 vs 2.6). Nationwide, the prevalence of human immunodeficiency virus is estimated at 0.45%, the prevalence of tuberculosis is 117 per 100 000, and the incidence of malaria is 258 per 100 000. Stunting in this community is high, whereas acute undernutrition is relatively uncommon. The population suffers from high rates of diarrheal disease. Prevalent enteric pathogens include Ascaris, Giardia, enterotoxigenic Escherichia coli, Shigella, and Campylobacter. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  3. Malária em usuários de drogas de administração endovenosa associada à soropositividade para HIV The association of malaria, HIV seropositivity and intravenous administration in drug users

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    Shin Shiang Lo

    1991-02-01

    Full Text Available Infecções induzidas de malária têm sido verificadas nos últimos anos no Estado de São Paulo, Brasil concomitantemente com o aumento de casos importados procedentes da região endêmica do país. Destaca-se o registro de um caso em 1988 e onze casos em 1989 de malária induzida por Plasmodium vivax, em indivíduos residentes na cidade de Presidente Prudente, situada a oeste do Estado e considerada uma das "portas de entrada" de pessoas procedentes da Região Amazônica. Os pacientes afirmaram não terem se deslocado recentemente ou negaram deslocamentos para áreas com possibilidade de transmissão de malária. Todos fizeram uso de drogas injetáveis, participando de círculos de conhecidos afins e geralmente dividiam a mesma agulha e seringa no uso da cocaína. Foi detectado o doente de malária que transmitiu inicialmente a doença ao caso de 1988, e a um primeiro grupo de três indivíduos em 1989. Destes três casos, um transmitiu a doença a outro grupo de dois indivíduos em 1989. A partir destas primeiras infecções e do uso continuado das drogas injetáveis entre grupos, surgiram dois novos casos e houve reinfecção em dois indivíduos (um destes apresentou duas reinfecções. O exame para detecção de HIV foi positivo em cinco indivíduos, um apresentou resultado negativo e não foi realizado em outros três indivíduos. São analisadas as informações desses casos e discutida a importância de sua ocorrência no momento atual.Cases of induced malaria have been notified in S. Paulo State, Brazil, in recent years. At the same time the number of cases imported from endemic regions of Brazil has been increasing. One case of induced malaria by Plasmodium vivax was registered in Presidente Prudente, located in the west of the State, in 1988 and a further eleven cases in 1989. This city is considered to be one of the main transit ports for people who come into the State from the Amazonian region. The patients declared that they had

  4. NOAA NOS SOS, EXPERIMENTAL, 1902-present, Salinity

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have salinity data. *These services are for testing and evaluation use...

  5. NOAA NOS SOS, EXPERIMENTAL, 1902-present, Conductivity

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have conductivity data. *These services are for testing and evaluation use...

  6. Metabolismo do ácido fólico na malária

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    Aymoré Vaz Pinto

    1983-06-01

    Full Text Available O estudo de 27 pacientes infectados pelo Plasmodium falciparum comparado com pessoas aparentemente sadias mostra: a diminuição do folato no soro dos pacientes infectados; b diminuição do folato sêrico nos primeiros 8 dias que seguiram ao tratamento, interpretados como sendo devido à mobilização pela eritropoiese compensadora; c folato eritrocítico normal.

  7. Nitric Oxide Synthase Enzymes in the Airways of Mice Exposed to Ovalbumin: NOS2 Expression Is NOS3 Dependent

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    Jennifer M. Bratt

    2010-01-01

    Full Text Available Objectives and Design. The function of the airway nitric oxide synthase (NOS isoforms and the lung cell types responsible for its production are not fully understood. We hypothesized that NO homeostasis in the airway is important to control inflammation, which requires upregulation, of NOS2 protein expression by an NOS3-dependent mechanism. Materials or Subjects. Mice from a C57BL/6 wild-type, NOS1−/−, NOS2−/−, and NOS3−/− genotypes were used. All mice strains were systemically sensitized and exposed to filtered air or ovalbumin (OVA aerosol for two weeks to create a subchronic model of allergen-induced airway inflammation. Methods. We measured lung function, lung lavage inflammatory and airway epithelial goblet cell count, exhaled NO, nitrate and nitrite concentration, and airway NOS1, NOS2, and NOS3 protein content. Results. Deletion of NOS1 or NOS3 increases NOS2 protein present in the airway epithelium and smooth muscle of air-exposed animals. Exposure to allergen significantly reduced the expression of NOS2 protein in the airway epithelium and smooth muscle of the NOS3−/− strain only. This reduction in NOS2 expression was not due to the replacement of epithelial cells with goblet cells as remaining epithelial cells did not express NOS2. NOS1−/− animals had significantly reduced goblet cell metaplasia compared to C57Bl/6 wt, NOS2−/−, and NOS3−/− allergen-exposed mice. Conclusion. The airway epithelial and smooth muscle cells maintain a stable airway NO concentration under noninflammatory conditions. This “homeostatic” mechanism is unable to distinguish between NOS derived from the different constitutive NOS isoforms. NOS3 is essential for the expression of NOS2 under inflammatory conditions, while NOS1 expression contributes to allergen-induced goblet cell metaplasia.

  8. Nitric Oxide Synthase Enzymes in the Airways of Mice Exposed to Ovalbumin: NOS2 Expression Is NOS3 Dependent

    Science.gov (United States)

    Bratt, Jennifer M.; Williams, Keisha; Rabowsky, Michelle F.; Last, Michael S.; Franzi, Lisa M.; Last, Jerold A.; Kenyon, Nicholas J.

    2010-01-01

    Objectives and Design. The function of the airway nitric oxide synthase (NOS) isoforms and the lung cell types responsible for its production are not fully understood. We hypothesized that NO homeostasis in the airway is important to control inflammation, which requires upregulation, of NOS2 protein expression by an NOS3-dependent mechanism. Materials or Subjects. Mice from a C57BL/6 wild-type, NOS1−/−, NOS2−/−, and NOS3−/− genotypes were used. All mice strains were systemically sensitized and exposed to filtered air or ovalbumin (OVA) aerosol for two weeks to create a subchronic model of allergen-induced airway inflammation. Methods. We measured lung function, lung lavage inflammatory and airway epithelial goblet cell count, exhaled NO, nitrate and nitrite concentration, and airway NOS1, NOS2, and NOS3 protein content. Results. Deletion of NOS1 or NOS3 increases NOS2 protein present in the airway epithelium and smooth muscle of air-exposed animals. Exposure to allergen significantly reduced the expression of NOS2 protein in the airway epithelium and smooth muscle of the NOS3−/− strain only. This reduction in NOS2 expression was not due to the replacement of epithelial cells with goblet cells as remaining epithelial cells did not express NOS2. NOS1−/− animals had significantly reduced goblet cell metaplasia compared to C57Bl/6 wt, NOS2−/−, and NOS3−/− allergen-exposed mice. Conclusion. The airway epithelial and smooth muscle cells maintain a stable airway NO concentration under noninflammatory conditions. This “homeostatic” mechanism is unable to distinguish between NOS derived from the different constitutive NOS isoforms. NOS3 is essential for the expression of NOS2 under inflammatory conditions, while NOS1 expression contributes to allergen-induced goblet cell metaplasia. PMID:20953358

  9. Simulação no contexto de problemas mal estruturados

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    Antônio Sérgio de Souza

    1994-12-01

    Full Text Available Simulação é atualmente reconhecida como uma poderosa ferramenta no projeto, análise e operação de sistemas produtivos. Apesar dos avanços recentes em linguagens de simulação, interfaces gráficas e geradores de aplicações, simulação ainda é uma técnica cara e pouco eficiente. Discute-se no texto algumas causas deste fato no contexto de problemas mal estruturados, como é o caso de planejamento e controle da produção. Discute-se a necessidade de realização da modelagem conceitual, não apenas como um passo estanque no processo de simulação, mas de forma progressiva e dinâmica, durante todo o ciclo de vida do projeto, servindo como uma interface entre os contextos real e de simulação.Simulation is now recognized as powerful tool in project, analyses and operation of produtive systems. Although the recent advances in simulation languages, graphical interfaces and in generating applications, simulation is still an expensive and not so efficient technique. In this text we dicuss some reasons for this in the context of not well strutured problems, asit is the case of production planning and control. It is also dicussed the necessity of developing the conceptual modeling of the real system, not only as a separated step in the simulation process, but in a progressive and dynamic way, during the project's life cycle as an interface between the real system and simulation.

  10. Effect of play therapy on behavioral problems of mal-adjusted pre-school children

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    Mehdi Khanbani

    2011-01-01

    Full Text Available Objective: The present research was conducted to study the effect of play therapy on reducing behavioral problems of mal-adjusted children (children with oppositional defiant disorder. Method: By using multistage cluster sampling, regions 6, 7, and 8 in Tehran were selected, and among kindergartens of these areas, 3 kindergartens under the support of welfare organization were randomly selected. From pre-school children of these 3 kindergartens, 40 children that could have behavioral disorder according to their teachers and parents complaints, were carefully tested, and among them, by the results obtained from child symptom inventory questionnaire (CSI-4, teacher's form, and a researcher-made self-control checklist, 16 children who showed severe symptoms of oppositional defiant disorder were selected, and they were randomly divided into control and experimental group. This research is quasi-experimental, and is done by the use of pre-test, post-test, and control group. Results: values of calculated F for oppositional defiant disorder in control and experimental group is meaningful after fixing the effect of pre-test (F(1,12=74/94, P<0/001 so there is a meaningful difference between means of disobedience disorder post-test scores in experimental and control group by having the fixed effect of pre-test effect. Comparison of adjusted means of 2 groups shows that the mean of attention-deficit hyperactivity disorder (ADHD in experimental group (M=14/09 is lower than control group (M=36/66. Therefore, applying play therapy in experimental group in comparison with control group, who did not receive these instructions, caused reduction in attention-deficit hyperactivity disorder (ADHD in pre-school children. Conclusion: Results of this research show that the children's disobedience is reduced by benefiting from play therapy.

  11. Comparison of measles complications in well nourished and mal-nourished children

    International Nuclear Information System (INIS)

    Qaisar, I.; Ahmad, A.; Ahmad, A.

    2009-01-01

    Measles is the most common and the most infectious of the viral infections of childhood. It can cause severe pneumonia, diarrhoea, encephalitis, and death. A significant proportion of deaths due to measles in young children worldwide are attributable to low weight for age. To compare the measles complications in well-nourished and mal-nourished children, this cross-sectional study was conducted at Paediatric out-patient department and paediatric unit 1 Bahawal Victoria Hospital Bahawalpur. Total 120 patients were included in the study. All patients presented with signs and symptoms suggestive of measles according to WHO criteria. These patients were divided into well nourished and malnourished according to the modified Gomez classification. Both groups were evaluated for measles complications like pneumonia, diarrhoea, encephalitis, corneal ulceration, thrombocytopenia, otitis media and myocarditis by detailed history and complete physical examination, and statistically analysed. In the studied patients, 75 were males and 45 were females. Mean age was 23 months. Fifty-nine (49.2%) patients were well-nourished and 61 (50.8%) were undernourished. Fifty-two (43.3%) patients were having pneumonia. Fifty-three (44.2%) patients were having diarrhoea. Twenty-six (21.7%) patients were having encephalitis. Corneal ulceration was found in 9 (7.5%) patients. Thrombocytopenia and otitis media was present in 1 patient in each group. Fourteen patients expired. Measles is a global epidemic problem having many serious complications, including pneumonia, diarrhoea, encephalitis, corneal ulcerations etc. Moreover these complications are more frequent in under nourished children. Efforts should be made to improve the nutritional status of the children and to eradicate this disease by effective vaccination. (author)

  12. Early childhood growth and cognitive outcomes: Findings from the MAL-ED study.

    Science.gov (United States)

    Scharf, Rebecca J; Rogawski, Elizabeth T; Murray-Kolb, Laura E; Maphula, Angelina; Svensen, Erling; Tofail, Fahmida; Rasheed, Muneera; Abreu, Claudia; Vasquez, Angel Orbe; Shrestha, Rita; Pendergast, Laura; Mduma, Estomih; Koshy, Beena; Conaway, Mark R; Platts-Mills, James A; Guerrant, Richard L; DeBoer, Mark D

    2018-02-02

    Although many studies around the world hope to measure or improve developmental progress in children to promote community flourishing and productivity, growth is sometimes used as a surrogate because cognitive skills are more difficult to measure. Our objective was to assess how childhood measures of anthropometry correlate with measures of child development in low-income settings with high prevalence of poor nutrition and enteric disease, to inform studies considering growth outcomes in the absence of direct child developmental skill assessment. Children from the MAL-ED study were followed from birth to 24 months of age in field sites in 8 low- and middle-income countries across 3 continents. Monthly weight, length, and head circumference measurements were performed. At 24 months, the Bayley Scales of Infant and Toddler Development was administered. We correlated cognitive measures at 24 months with anthropometric measurements from birth to 2 years comparing 3 constructs: absolute attained monthly measures, summative difference in measures from the mean growth curve, and rate of change in measures. Growth faltering at multiple time periods is related to Bayley cognitive outcomes at 24 months. Birthweight, overall growth by 18-24 months, and rate of growth in the 6- to 18-month period were most associated with 24-month developmental scores. In this study, head circumference measurements, compared with length, was more closely linked to cognitive scores at 24 months. Notably, all studies between growth and cognitive outcomes exhibited low r 2 values (0.001-0.049). Anthropometric measures, particularly head circumference, were related to cognitive development, although explaining a low percent of variance. When feasible, direct measures of child development may be more useful. © 2018 John Wiley & Sons Ltd.

  13. MalHaploFreq: A computer programme for estimating malaria haplotype frequencies from blood samples

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    Smith Thomas A

    2008-07-01

    Full Text Available Abstract Background Molecular markers, particularly those associated with drug resistance, are important surveillance tools that can inform policy choice. People infected with falciparum malaria often contain several genetically-distinct clones of the parasite; genotyping the patients' blood reveals whether or not the marker is present (i.e. its prevalence, but does not reveal its frequency. For example a person with four malaria clones may contain both mutant and wildtype forms of a marker but it is not possible to distinguish the relative frequencies of the mutant and wildtypes i.e. 1:3, 2:2 or 3:1. Methods An appropriate method for obtaining frequencies from prevalence data is by Maximum Likelihood analysis. A computer programme has been developed that allows the frequency of markers, and haplotypes defined by up to three codons, to be estimated from blood phenotype data. Results The programme has been fully documented [see Additional File 1] and provided with a user-friendly interface suitable for large scale analyses. It returns accurate frequencies and 95% confidence intervals from simulated dataset sets and has been extensively tested on field data sets. Additional File 1 User manual for MalHaploFreq. Click here for file Conclusion The programme is included [see Additional File 2] and/or may be freely downloaded from 1. It can then be used to extract molecular marker and haplotype frequencies from their prevalence in human blood samples. This should enhance the use of frequency data to inform antimalarial drug policy choice. Additional File 2 executable programme compiled for use on DOS or windows Click here for file

  14. Isolation of Mal d 1 and Api g 1 - specific recombinant antibodies from mouse IgG Fab fragment libraries - Mal d 1-specific antibody exhibits cross-reactivity against Bet v 1.

    Science.gov (United States)

    Haka, Jaana; Niemi, Merja H; Iljin, Kristiina; Reddy, Vanga Siva; Takkinen, Kristiina; Laukkanen, Marja-Leena

    2015-05-27

    Around 3-5% of the population suffer from IgE-mediated food allergies in Western countries and the number of food-allergenic people is increasing. Individuals with certain pollen allergies may also suffer from a sensitisation to proteins in the food products. As an example a person sensitised to the major birch pollen allergen, Bet v 1, is often sensitised to its homologues, such as the major allergens of apple, Mal d 1, and celery, Api g 1, as well. Development of tools for the reliable, sensitive and quick detection of allergens present in various food products is essential for allergic persons to prevent the consumption of substances causing mild and even life-threatening immune responses. The use of monoclonal antibodies would ensure the specific detection of the harmful food content for a sensitised person. Mouse IgG antibody libraries were constructed from immunised mice and specific recombinant antibodies for Mal d 1 and Api g 1 were isolated from the libraries by phage display. More detailed characterisation of the resulting antibodies was carried out using ELISA, SPR experiments and immunoprecipitation assays. The allergen-specific Fab fragments exhibited high affinity towards the target recombinant allergens. Furthermore, the Fab fragments also recognised native allergens from natural sources. Interestingly, isolated Mal d 1-specific antibody bound also to Bet v 1, the main allergen eliciting the cross-reactivity syndrome between the birch pollen and apple. Despite the similarities in Api g 1 and Bet v 1 tertiary structures, the isolated Api g 1-specific antibodies showed no cross-reactivity to Bet v 1. Here, high-affinity allergen-specific recombinant antibodies were isolated with interesting binding properties. With further development, these antibodies can be utilised as tools for the specific and reliable detection of allergens from different consumable products. This study gives new preliminary insights to elucidate the mechanism behind the pollen

  15. Malária e aspectos hematológicos em moradores da área de influência dos futuros reservatórios das hidrelétricas de Santo Antônio e Jirau, Rondônia, Brasil Malaria and hematological aspects among residents to be impacted by reservoirs for the Santo Antônio and Jirau Hydroelectric Power Stations, Rondônia State, Brazil

    Directory of Open Access Journals (Sweden)

    Tony Hiroshi Katsuragawa

    2009-07-01

    Full Text Available Em Rondônia, prevê-se a construção de mais duas usinas hidrelétricas (UHE no rio Madeira, a montante da cidade de Porto Velho, Rondônia, Brasil (de Santo Antônio e Jirau. O objetivo deste trabalho foi analisar a prevalência da malária antes do início da implantação das obras civis e fazer considerações sobre os impactos da doença com o ingresso de milhares de trabalhadores e agregados atraídos pelas oportunidades de emprego e comércio. Os resultados obtidos mostram que a malária se faz presente em toda região, em variados graus de prevalência. Além disso, a existência de potenciais portadores assintomáticos de malária entre a população nativa pode ter relevância epidemiológica e deve ser considerada nos programas de controle da malária, vinda tanto das autoridades públicas quanto das empresas responsáveis pela instalação das UHE, visando o diagnóstico e tratamento precoce, controle vetorial, abastecimento de água e aplicação de infra-estrutura nos centros urbanos.In Rondônia State, Brazil, two new hydroelectric plants, Santo Antônio and Jirau, are scheduled for construction on the Madeira River, upriver from the State capital, Porto Velho. The current study analyzes malaria prevalence before the construction and provides information on the possible impacts of malaria burden related to the influx of thousands of persons attracted by direct and indirect employment opportunities. According to the findings, malaria is present throughout the region, with varying prevalence rates. The existence of potential asymptomatic malaria carriers among the local population may be epidemiologically relevant and should be considered in the malaria control programs organized by public authorities and companies responsible for building the power plants, aimed at early diagnosis and treatment, vector control, water supply, and infrastructure in the urban areas.

  16. Estressores no trabalho das enfermeiras em centro cirúrgico: conseqüências profissionais e pessoais

    OpenAIRE

    Jael Maria de Aquino

    2005-01-01

    O estresse tem sido um tema bastante discutido, nos últimos anos, pela comunidade científica. Vários estudos têm apresentado o estresse como causador de doenças, sendo considerado o “mal do século”. O centro cirúrgico é um dos ambientes mais complexos do hospital, pois concentra os recursos humanos e materiais necessários ao ato cirúrgico e, freqüentemente, as suas atividades são desenvolvidas em um clima de tensão, pela existência de procedimentos estressantes geradores de ansiedade, quer pe...

  17. Brucella TIR-like protein TcpB/Btp1 specifically targets the host adaptor protein MAL/TIRAP to promote infection.

    Science.gov (United States)

    Li, Wenna; Ke, Yuehua; Wang, Yufei; Yang, Mingjuan; Gao, Junguang; Zhan, Shaoxia; Xinying, Du; Huang, Liuyu; Li, Wenfeng; Chen, Zeliang; Li, Juan

    2016-08-26

    Brucella spp. are known to avoid host immune recognition and weaken the immune response to infection. Brucella like accomplish this by employing two clever strategies, called the stealth strategy and hijacking strategy. The TIR domain-containing protein (TcpB/Btp1) of Brucella melitensis is thought to be involved in inhibiting host NF-κB activation by binding to adaptors downstream of Toll-like receptors. However, of the five TIR domain-containing adaptors conserved in mammals, whether MyD88 or MAL, even other three adaptors, are specifically targeted by TcpB has not been identified. Here, we confirmed the effect of TcpB on B.melitensis virulence in mice and found that TcpB selectively targets MAL. By using siRNA against MAL, we found that TcpB from B.melitensis is involved in intracellular survival and that MAL affects intracellular replication of B.melitensis. Our results confirm that TcpB specifically targets MAL/TIRAP to disrupt downstream signaling pathways and promote intra-host survival of Brucella spp. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. A formação humana e a incapacidade de pensar: considerações sobre o problema do mal em Hannah Arendt

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    Marcos Alexandre Alves

    2017-08-01

    Full Text Available Este artigo pretende apresentar o tema da formação humana conectado à incapacidade de pensar, tecendo considerações sobre o problema do mal no pensamento de Hannah Arendt. A autora é conhecida como pensadora da política que concentrou atenção especial ao problema do mal que assolou o mundo na primeira metade do século XX. A partir da análise de Origens do Totalitarismo, de 1951, e de Eichmann em Jerusalém: um relato sobre a banalidade do mal, de 1963, pretende-se refletir acerca dos mecanismos que produzem o adormecimento da capacidade de pensar frente à necessidade da formação humana. A partir dessa análise, se perceberá que o problema do mal assume um viés radical, uma possibilidade de destruição completa do humano. Na análise do caso Eichmann, Arendt percebeu que o réu agia banalmente, manifestando sua incapacidade de pensar, o que tornou possível a normalização da insensibilidade frente o diferente. Portanto, a banalidade do mal implica na incapacidade de pensar, uma ameaça sempre constante à formação humana

  19. Multifaceted NOS Instruction: Contextualizing Nature of Science with Documentary Films

    Science.gov (United States)

    Bloom, Mark; Binns, Ian C.; Koehler, Catherine

    2015-01-01

    This research focuses on inservice science teachers' conceptions of nature of science (NOS) before and after a two-week intensive summer professional development (PD). The PD combined traditional explicit NOS instruction, numerous interactive interventions that highlighted NOS aspects, along with documentary films that portrayed NOS in context of…

  20. Malária pulmonar: aspectos na tomografia computadorizada de alta resolução - relato de caso

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    Rodrigues Rosana

    2004-01-01

    Full Text Available Neste trabalho é relatado o caso de paciente do sexo masculino, de 38 anos de idade, que desenvolveu quadro de malária com comprometimento pulmonar. A tomografia computadorizada de alta resolução evidenciou espessamento de septos interlobulares e de bainhas peribroncovasculares, com áreas esparsas de atenuação em vidro fosco e de consolidações, além de derrame pleural bilateral, aspectos compatíveis com edema pulmonar. O paciente recebeu tratamento específico, evoluindo bem e tendo alta 11 dias após a internação.

  1. Orthodontic force stimulates eNOS and iNOS in rat osteocytes

    NARCIS (Netherlands)

    Tan, S.D.; Xie, R.; Klein Nulend, J.; van Rheden, R.E.; Bronckers, A.L.J.J.; Kuijpers-Jagtman, A.M.; Von den Hoff, J.W.; Maltha, J.C.

    2009-01-01

    Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these

  2. Orthodontic force stimulates eNOS and iNOS in rat osteocytes.

    NARCIS (Netherlands)

    Tan, S.D.; Xie, R.; Klein-Nulend, J.; Rheden, R.E.M. van; Bronckers, A.L.; Kuijpers-Jagtman, A.M.; Hoff, J.W. Von den; Maltha, J.C.

    2009-01-01

    Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of constitutive endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS). We hypothesized that these

  3. Treatment of the Mal de Debarquement Syndrome: A 1-Year Follow-up

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    Mingjia Dai

    2017-05-01

    Full Text Available The mal de debarquement syndrome (MdDS is a movement disorder, occurring predominantly in women, is most often induced by passive transport on water or in the air (classic MdDS, or can occur spontaneously. MdDS likely originates in the vestibular system and is unfamiliar to many physicians. The first successful treatment was devised by Dai et al. (1, and over 330 MdDS patients have now been treated. Here, we report the outcomes of 141 patients (122 females and 19 males treated 1 year or more ago. We examine the patient’s rocking frequency, body drifting, and nystagmus. The patients are then treated according to these findings for 4–5 days. During treatment, patients’ heads were rolled while watching a rotating full-field visual surround (1. Their symptom severity after the initial treatment and at the follow-up was assessed using a subjective 10-point scale. Objective measures, taken before and at the end of the week of treatment, included static posturography. Significant improvement was a reduction in symptom severity by more than 50%. Objective measures were not possible during the follow-up because of the wide geographic distribution of the patients. The treatment group consisted of 120 classic and 21 spontaneous MdDS patients. The initial rate of significant improvement after a week of treatment was 78% in classic and 48% in spontaneous patients. One year later, significant improvement was maintained in 52% of classic and 48% of spontaneous subjects. There was complete remission of symptoms in 27% (32 of classic and 19% (4 of spontaneous patients. Although about half of them did not achieve a 50% improvement, most reported fewer and milder symptoms than before. The success of the treatment was generally inversely correlated with the duration of the MdDS symptoms and with the patients’ ages. Prolonged travel by air or car on the way home most likely contributed to the symptomatic reversion from the initial successful treatment

  4. Efeitos benéficos e maléficos da malva sylvestris

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    Ana Carolina Locatelli Ecker

    2016-04-01

    Full Text Available Objetivo. Revisar os efeitos benéficos e maléficos da Malva sylvestris para a saúde humana. Materiais e métodos. Foi realizada uma busca na base de dados BIREME, em setembro de 2014, por meio das pala­vras chaves malva AND sylvestris. Foram incluídos os artigos na língua inglesa e portuguesa sem limite de tempo. Foram excluídos os estudos repetidos e aqueles que não abordavam o tema. Resultados. Atra­vés da busca realizada, foram encontrados 56 artigos, destes, foram excluídos dois repetidos, um por encontrar-se no idioma chinês e, 41 por estarem fora do tema (benefícios para animais e solo, proprie­dades químicas da erva, pesquisa em campo de determinadas regiões do mundo abrangendo índices de utilização de muitas espécies de plantas para fins medicinais. Assim, foram, incluídos 12 artigos. Com grande importância terapêutica, a erva tem sido utilizada na área da saúde em geral para inflamações internas e externas, fins quimio-preventivos e antissépticos. Também alivia secreções como catarros, congestionamento das vias respiratórias e age como calmante no sistema neurológico. Segundo pes­quisas, o chá de malva apresenta resultados mais vantajosos do que tratamentos medicamentosos e é uma das mais utilizadas como auto-medicação. Conclusão. A Malva sylvestris é utilizada para muitos fins benéficos para o ser humano desde tempos remotos, mas sua comprovação científica tem ocorrido atualmente, evidenciando a veracidade de suas vantagens na saúde e no tratamento de patologias.

  5. EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE

    Science.gov (United States)

    Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

    2012-01-01

    El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

  6. Comportamento epidemiológico da malária no Estado de Mato Grosso, 1980-2003 Epidemiological trends of malaria in the State of Mato Grosso, from 1980 to 2003

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    Marina Atanaka-Santos

    2006-04-01

    Full Text Available Descreveu-se a evolução temporal e espacial de malária em Mato Grosso, discriminadas em períodos de 1980-1985; 1986-1991; 1992-1997 e 1998-2003, distribuídas por microrregião homogênea. O índice parasitário anual do estado cresceu até 1992, reduzindo para 1,9 casos/mil habitantes em 2003; o coeficiente de mortalidade e a taxa de letalidade foram maiores nos anos de 1980 a 1989. Das 22 microrregiões, 13 apresentaram IPA inferior a 10 casos/1.000 habitantes em todos os períodos, ocorrendo concentração de casos nas microrregiões de Colíder, Alta Floresta, Aripuanã e Alto Guaporé. Em 2003, apenas a microrregião de Aripuanã persistia com IPA superior a 50 casos/1.000 habitantes. As microrregiões de Colíder, em 1983, 1985 a 1988 e 1990 e Alta Floresta, em 1991, apresentaram óbitos acima de 50/100.000 habitantes, sendo a maioria do sexo masculino, na faixa etária de 20 a 49 anos. A distribuição da doença por microrregiões evidenciou que a malária é predominantemente focal.The temporal and spatial evolution of malaria in Mato Grosso was determined in periods from 1980-1985, 1986-1991, 1992-1997 and 1998-2003 and distributed by homogeneous microregion. The annual parasitic index of the state rose until 1992 and then diminished to 1.9 cases/1,000 inhabitants in 2003, the ratio of mortality and the lethality rate were greater in the 1980s. Of the 22 microregions, 13 presented an API inferior to 10 cases/1,000 inhabitants in all periods. Cases were concentrated in the microregions of Colíder, Alta Floresta, Aripuanã and Alto Guaporé. In 2003, only the microregion of Aripuanã continued to present an API superior to 50 cases/1,000 inhabitants. The microregions of Colíder, in 1983, 1985 to 1988 and 1990 and Alta Floresta, in 1991 presented deaths over 50/100,000 inhabitants, mainly in males aged 20-49 years. The distribution of the disease in microregions showed that malaria is predominantly found in concentrated sites.

  7. Marketing plan NOS: introducing pay per view

    OpenAIRE

    Pereira, Pedro Azeredo

    2016-01-01

    NOS, NOS Comunicações S.A., is a private telecommunications company of the portuguese market which is proud of being the “best communications and entertainment company in the market”. The company was born from a fusion between two of the biggest communications corporations in the country: on the fixed service (TV, fixed phone, fixed internet, etc.) from ZON; and on the mobile service (mobile phone, internet, etc.) from Optimus. It is a leader in all the sectors it operates. Bes...

  8. Securitización en el desierto: Una respuesta al terrorismo en Malí y en Níger, 2009 - 2013.

    OpenAIRE

    Guerrero Escobar, Laura Catalina

    2014-01-01

    Este es un estudio sobre las dinámicas de seguridad en Malí durante el periodo de 2009 a 2013. La investigación busca explicar de qué manera se ha dado un proceso de securitización de los grupos insurgentes frente a la amenaza generada por la proliferación de grupos armados no estatales en el territorio comprendido entre Malí y Níger. Se toma a Níger con el ánimo de ver la existencia de un subcomplejo regional de seguridad entre este país y Malí. De esta manera se afirma que el aumento de las...

  9. malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication

    Science.gov (United States)

    2017-01-01

    Basic science holds enormous power for revealing the biological mechanisms of disease and, in turn, paving the way toward new, effective interventions. Recognizing this power, the 2011 Research Agenda for Malaria Eradication included key priorities in fundamental research that, if attained, could help accelerate progress toward disease elimination and eradication. The Malaria Eradication Research Agenda (malERA) Consultative Panel on Basic Science and Enabling Technologies reviewed the progress, continuing challenges, and major opportunities for future research. The recommendations come from a literature of published and unpublished materials and the deliberations of the malERA Refresh Consultative Panel. These areas span multiple aspects of the Plasmodium life cycle in both the human host and the Anopheles vector and include critical, unanswered questions about parasite transmission, human infection in the liver, asexual-stage biology, and malaria persistence. We believe an integrated approach encompassing human immunology, parasitology, and entomology, and harnessing new and emerging biomedical technologies offers the best path toward addressing these questions and, ultimately, lowering the worldwide burden of malaria. PMID:29190277

  10. Fingerpainting am Touchscreen. Fünf Mal- und Zeichen-Apps für Android-Tablets

    Directory of Open Access Journals (Sweden)

    Christoph Kaindel

    2015-06-01

    Full Text Available Malen auf dem Touchscreen eines Smartphones oder Tablets ist eine natürliche und intuitive Tätigkeit; anders als bei der Nutzung eines Grafiktabletts am PC gibt es so gut wie keine Umstellungsphase. Christoph Kaindel hat für uns fünf Mal- und Zeichen-Apps unter die Lupe genommen. Bereits für Kinder ist in den diversen Appstores eine große Zahl an einfachen Mal-Apps zu finden, mit meist nur wenigen Einstellungsmöglichkeiten und oft fragwürdiger Qualität. Am anderen Ende des Spektrums liegt der professionelle Einsatz von Tablets im Grafikbereich, für den spezialisierte und entsprechend teure Geräte notwendig sind. Ich werde einige Apps aus dem Mittelfeld vorstellen, die sich für einfache wie anspruchsvolle Vorhaben und Projekte eignen, auch auf schwächeren Tablets laufen und preisgünstig oder gratis sind. Alle Apps bieten die Möglichkeit, unterwegs zu malen, zu skizzieren, Fotos zu verfremden und die entstandenen Bilder am PC weiter bearbeiten zu können. Für PCs gibt es einige empfehlenswerte kostenlose Malprogramme, die ich bereits in einem anderen Artikel (http://medienimpulse.at/articles/view/616 vorgestellt habe.

  11. Presencia de Anopheles (Nyssorhynchus benarrochi en áreas de selva con transmisión malárica

    Directory of Open Access Journals (Sweden)

    Roberto Fernández L

    2004-10-01

    Full Text Available Objetivos: Demostrar la presencia de An. (Nys. benarrochi en áreas de transmisión malárica, donde es frecuentemente identificado como An. evansae. Materiales y métodos: Se colectaron mosquitos en San José (Pucallpa, Muniches y Andoas (Alto Amazonas, localidades con transmisión de malaria. Con estos mosquitos se efectuaron crías biológicas en laboratorio con la finalidad de obtener material de estudio como son exuvias de larvas, pupas, adultos hembras y machos. Se efectuaron montajes de exuvias de larvas y pupas asociados con sus respectivos adultos, disecciones de las genitalias de machos y biometría de los adultos machos y hembras. Resultados: Además de las verificaciones efectuadas en el campo, basadas en el estudio de inmaduros y adultos, las crías biológicas efectuadas confirmaron la presencia de An. benarrochi en las localidades mencionadas. Asimismo, confirmaron también la existencia de gran variabilidad de los caracteres morfológicos externos, que pueden inducir al error en las identificaciones. Conclusiones: En las áreas maláricas estudiadas, la especie identificada como An. (Nys. evansae corresponde a An. (Nys. benarrochi, demostrado con nuestros estudios. Dada la variabilidad de caracteres que dificultan la identificación de las especies afines, es necesario realizar estudios completos con la finalidad de conocer la fauna local de anofelinos.

  12. A banalidade do mal e as possibilidades da educação moral: contribuições arendtianas

    Directory of Open Access Journals (Sweden)

    Marcelo Andrade

    2010-01-01

    Full Text Available Más que una época de crisis, enfrentamos hoy una crisis de época en la cual la educación desempeña un papel fundamental. En este sentido, el presente trabajo es una relectura de la obra de Hannah Arendt, filósofa que pensó y vivió en tiempos sombríos, con el fin de aclarar algunos conceptos que son fundamentales para que hoy pueda repensarse la educación moral o la educación en valores. A través de un estudio centrado en las obras Eichmann en Jerusalén: un estudio sobre la banalidad del mal y La vida del espíritu, este trabajo busca comprender cómo y por qué Hannah Arendt acuñó el concepto banalidad del mal y en qué sentido este se relaciona con el vacío del pensamiento y con una propuesta de educación en valores.

  13. FORMAS E PROCESSOS CÁRSICOS NOS MACIÇOS CALCÁRIOS DO CENTRO DE PORTUGAL. O CASO PARTICULAR DO MACIÇO DE SICÓ

    Directory of Open Access Journals (Sweden)

    Lúcio Cunha

    2014-12-01

    Full Text Available No Centro Litoral de Portugal continental, no espaço que estruturalmente pertence à chamada Bacia Lusitânica, as rochas carbonatadas jurássicas são responsáveis por um conjunto de pequenos Maciços Calcários, salientes na paisagem, quer pelo comportamento diferencial das litologias, quer pela atuação da tectónica alpina. Nestes maciços, os processos de evolução cársica, relacionados com a solubilidade da rocha e com a sua permeabilidade “em grande” são responsáveis por paisagens com características bem particulares, em que a tendência para a formação de bacias fechadas à superfície se adequa à proliferação de cavidades subterrâneas. Destes, o Maciço de Sicó, apesar da sua reduzida dimensão (pouco mais de 400 km2 apresenta nos seus diferentes compartimentos uma enorme variedade de formas cársicas (lapiás, dolinas, canhões fluviocársicos, grutas, abrigos sob rocha, exsurgências, muitas das quais com elevado valor em termos patrimoniais, mas também com alguns problemas de geoconservação. A especificidade morfológica do Maciço de Sicó advém sobretudo de se tratar de um carso coberto, com uma exumação incompleta em que os processos cársicos e fluviais interagiram e interagem na construção de uma paisagem em que os vales fluviocársicos, as formas superficiais fechadas, as grutas, as “buracas” e os lapiás coexistem num sistema complexo resultante de uma evolução polifásica e poligénica em que se encontram refletidos diferentes tempos e distintos ambientes.

  14. First successful reduction of clinical allergenicity of food by genetic modification: Mal d 1-silenced apples cause fewer allergy symptoms than the wild-type cultivar

    DEFF Research Database (Denmark)

    Dubois, A. E. J.; Pagliarani, G.; Brouwer, R. M.

    2015-01-01

    BACKGROUND: Genetic modification of allergenic foods such as apple has the potential to reduce their clinical allergenicity, but this has never been studied by oral challenges in allergic individuals. METHODS: We performed oral food challenges in 21 apple-allergic individuals with Elstar apples...... which had undergone gene silencing of the major allergen of apple, Mal d 1, by RNA interference. Downregulation of Mal d 1 gene expression in the apples was verified by qRT-PCR. Clinical responses to the genetically modified apples were compared to those seen with the wild-type Elstar using a visual...

  15. Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

    Science.gov (United States)

    Dunne, Aisling; Ejdeback, Mikael; Ludidi, Phumzile L; O'Neill, Luke A J; Gay, Nicholas J

    2003-10-17

    The Toll/interleukin 1 receptor (TIR) domain is a region found in the cytoplasmic tails of members of the Toll-like receptor/interleukin-1 receptor superfamily. The domain is essential for signaling and is also found in the adaptor proteins Mal (MyD88 adaptor-like) and MyD88, which function to couple activation of the receptor to downstream signaling components. Experimental structures of two Toll/interleukin 1 receptor domains reveal a alpha-beta-fold similar to that of the bacterial chemotaxis protein CheY, and other evidence suggests that the adaptors can make heterotypic interactions with both the receptors and themselves. Here we show that the purified TIR domains of Mal and MyD88 can form stable heterodimers and also that Mal homodimers and oligomers are dissociated in the presence of ATP. To identify structural features that may contribute to the formation of signaling complexes, we produced models of the TIR domains from human Toll-like receptor 4 (TLR4), Mal, and MyD88. We found that although the overall fold is conserved the electrostatic surface potentials are quite distinct. Docking studies of the models suggest that Mal and MyD88 bind to different regions in TLRs 2 and 4, a finding consistent with a cooperative role of the two adaptors in signaling. Mal and MyD88 are predicted to interact at a third non-overlapping site, suggesting that the receptor and adaptors may form heterotetrameric complexes. The theoretical model of the interactions is supported by experimental data from glutathione S-transferase pull-downs and co-immunoprecipitations. Neither theoretical nor experimental data suggest a direct role for the conserved proline in the BB-loop in the association of TLR4, Mal, and MyD88. Finally we show a sequence relationship between the Drosophila protein Tube and Mal that may indicate a functional equivalence of these two adaptors in the Drosophila and vertebrate Toll pathways.

  16. Alterações do desenvolvimento de crianças prematuras nascidas de mães com malária no periodo gestacional

    OpenAIRE

    Simões, Maria da Conceição Ribeiro

    2012-01-01

    Objetivo : O estudo buscou avaliar as alterações no desenvolvimento de crianças prematuras nascidas de mães com malária no periodo gestacional, em Porto Velho, Rondônia. O objetivo principal é descrever as alterações encontradas nessas crianças aplicando um teste preditivo para alterações no desenvolvimento e compará-las à um grupo controle de crianças prematuras nascidas de mães que não apresentaram malária no periodo gestacional. Métodos : Por ser um estudo do tipo transvers...

  17. Construyendo resiliencia socioecológica en huertos urbanos y periurbanos en Querétaro; adaptaciones urbanas ante el desafío de la soberanía alimentaria y el cambio climático : Hacia la activación de un diálogo de saberes de urbicultor a urbicultor

    OpenAIRE

    Villavicencio Valdez, Gabriela; Suzán Azpiri, Humberto; Ribeiro Palacios, Mónica; Altieri, M. A.

    2015-01-01

    La resiliencia socioecológica depende tanto de las amenazas, la vulnerabilidad y de la capacidad adaptativa de sistemas agroecológicos para diversificar, promover interacciones y sinergias benéficas entre sus componentes, regenerar la fertilidad del suelo, mantener la productividad, proteger los cultivos y recuperarse de los daños causados. Se evaluará la resiliencia socioecológica de los 28 huertos urbanos identificados en la zona urbana y metropolitana de Querétaro en el contexto del cambio...

  18. Mal tiempo, tiempo maligno, tiempo de subversión ritual. La temposensitividad agrofestiva invernal

    Directory of Open Access Journals (Sweden)

    Del Campo Tejedor, Alberto

    2006-06-01

    ícolas y expresivo (rituales y fiestas; y, finalmente, un tiempo bipolar, que se experimenta desde antiguo en dos estaciones —invierno y verano—, base de una temposensitividad agrofestiva igualmente dicotómica, que es analizada a raíz de la siguiente hipótesis: durante los meses de buen tiempo, especialmente mayo y junio, los rituales de nuestro entorno funcionan con un sentido propiciatorio y de exaltación positiva, escenificando miméticamente la unión entre tierra, vegetación, animal y hombre a través de prototipos o arquetipos que recrean simbólicamente el orden natural de las cosas. Por el contrario, las fiestas y rituales invernales —desde Todos los Santos hasta el Carnaval, y muy especialmente los días en torno a la Navidad— tienen en común su carácter grotesco y de inversión del orden, que expresa en clave simbólica, con una lógica jocoseria y ambigua, el lado oscuro de la existencia, conjurando ritualmente los miedos al mal tiempo, al tiempo aciago y nefasto, al tiempo del frío, la noche, el hambre y la muerte.

  19. Mal de Asclepio o Síndrome Judicial Médico

    Directory of Open Access Journals (Sweden)

    Hernán Urbina Joiro

    2015-12-01

    Full Text Available

    Se asocian crecientemente, de manera criminal, abogados, pacientes y médicos perversos contra médicos honestos, alineando el factor que peor puede degradar la medicina de hoy y potenciar sus otros males. Siendo dios de la medicina, el nacimiento y la muerte de Asclepio estuvieron marcados por la vileza, la que hoy amenaza de muerte a la profesión médica. Pero no hay que olvidar que finalmente Asclepio pudo ser resguardado de la perversidad.

    No se trata de la situación de quien denuncia legítimamente una transgresión cometida por un médico. El Mal de Asclepio o Síndrome Judicial Médico describe la actuación calculada por auténticos «enfermos» —en el sentido sociopático—, con manifiesta intención de ocasionar daño a médicos inocentes, comúnmente a través de prácticas delictivas, ocasionando además males permanentes en la salud física y mental de quienes se habían esforzado, irónicamente, para sanar a los demás, en esta era de degradación de la profesión médica, en este momento extraño donde el bastón de Asclepio, dios de la medicina, fue cambiado por el caduceo de Mercurio, dios del comercio y también de los ladrones (1.

    Asclepio fue un hijo no nacido, rescatado por un prodigio desde el vientre de su madre muerta y a punto de ser consumida por la pira funeraria. Coronis —o Corónide—, la madre, lo concibió tras un asalto del dios Apolo en la rivera de un río y, sin saber de su estado, cumplió con un pacto matrimonial arreglado por su padre, lo que incitó a Apolo a dar muerte a su joven esposo e impulsó a Artemisa, hermana de Apolo, a asesinar a flechazos a la propia Coronis. Fue el mismo Apolo quien, en el último momento, resolvió extraer del cadáver de Coronis al niño que puso por nombre Asclepio y que en adelante lucharía contra la muerte, incluso resucitando difuntos, hasta que la propia muerte —Hades— convenció de mala fe a Zeus, lo indujo al error —que más tarde

  20. O problema do mal: a interpretação de São Boaventura = The problem of evil: the interpretation of Saint Bonaventure

    Directory of Open Access Journals (Sweden)

    Vasconcellos, Manoel

    2012-01-01

    Full Text Available Tomando, especialmente, o Breviloquium como guia, podemos entender o modo como São Boaventura analisa o problema do mal e sua relação com o pecado. O homem foi criado bom, para viver num mundo bom. Com o pecado, rompeu com o projeto divino, instaurando o mal no mundo. Deus, o princípio primeiro e perfeitíssimo, contudo, não deixa de levar à perfeição sua obra, razão pela qual vem ao encontro do homem para vencer o pecado e o mal. Numa reflexão em que Filosofia e Teologia se entrecruzam, Boaventura, ao discorrer sobre a origem, transmissão e superação do mal, deixa transparecer o papel singular e afirmativo do homem, pois, apesar do pecado, não perdeu sua atração natural às virtudes, sendo capaz de agir bem

  1. Development of hypo-allergenic apples: silencing of the major allergen Mal d 1 gene in "Elstar" apple and the effect of grafting

    DEFF Research Database (Denmark)

    Krath, Britta; Eriksen, Folmer Damsted; Pedersen, Bjarne H.

    2009-01-01

    Many people who are allergic to birch pollen are also allergic to apple fruit, due to cross-allergenicity. Since apples are the most extensively consumed fruit in Europe, it is highly relevant to develop a hypo-allergenic apple. Apples with significantly reduced levels of the allergen, Mal d 1, may...

  2. CADM1, MAL and miR124-2 methylation analysis in cervical scrapes to detect cervical and endometrial cancer

    NARCIS (Netherlands)

    De Strooper, Lise M. A.; van Zummeren, Marjolein; Steenbergen, Renske D. M.; Bleeker, Maaike C. G.; Hesselink, Albertus T.; Schuurs-Wisman, G. Bea A.; Snijders, Peter J. F.; Heideman, Danielle A. M.; Meijer, Chris J. L. M.

    2014-01-01

    Aims Gene promoter hypermethylation is recognised as an essential early step in carcinogenesis, indicating important application areas for DNA methylation analysis in early cancer detection. The current study was set out to assess the performance of CADM1, MAL and miR124-2 methylation analysis in

  3. A Linguagem Motion Graphics nos Videoclipes Brasileiros

    Directory of Open Access Journals (Sweden)

    Herom Vargas

    2013-08-01

    Full Text Available Com o desenvolvimento das tecnologias digitais de edição, animação e pós-produção, a linguagem motion graphics se configurou como ferramenta criativa nas relações entre som e imagem. Este artigo tem como objetivo identificar e analisar aspectos inovadores da utilização da linguagem motion graphics nos videoclipes de artistas brasileiros, no período de 1990 a 2010. Por meio de categorias de avaliação relacionadas 1 aos softwares de composição visual, 2 à evolução da linguagem do clipe no período e 3 às relações entre música, vídeo e gráficos utilizados, quatro estágios de aplicação criativa dos recursos dessa linguagem nos videoclipes brasileiros foram estabelecidos.

  4. ¿Las emociones nos distraen?

    Directory of Open Access Journals (Sweden)

    Antonia Pilar Pacheco-Unguetti

    2014-06-01

    Full Text Available ¿Leerás este artículo hasta el final sin interrupciones? Puede que, mientras lo intentas, recibas algún mensaje de whatsapp, se abra una ventana emergente en tu ordenador con una oferta de viajes al Caribe o el cartero llame dos veces a tu puerta. También puede ser que simplemente no tengas un buen día y te resulte especialmente difícil concentrarte. Vivimos expuestos a multitud de estímulos distractores externos, algunos tan inesperados o extraños que entorpecen irremediablemente nuestra concentración en una tarea (distracción por novedad. Pero la distracción también puede tener una causa interna y cómo nos sentimos puede influir en cuánto nos distraemos.

  5. Molecular characterization of multivalent bioconjugates by size-exclusion chromatography (SEC) with multi-angle laser light scattering (MALS)

    Science.gov (United States)

    Pollock, Jacob F.; Ashton, Randolph S.; Rode, Nikhil A.; Schaffer, David V.; Healy, Kevin E.

    2013-01-01

    The degree of substitution and valency of bioconjugate reaction products are often poorly judged or require multiple time- and product- consuming chemical characterization methods. These aspects become critical when analyzing and optimizing the potency of costly polyvalent bioactive conjugates. In this study, size-exclusion chromatography with multi-angle laser light scattering was paired with refractive index detection and ultraviolet spectroscopy (SEC-MALS-RI-UV) to characterize the reaction efficiency, degree of substitution, and valency of the products of conjugation of either peptides or proteins to a biopolymer scaffold, i.e., hyaluronic acid (HyA). Molecular characterization was more complete compared to estimates from a protein quantification assay, and exploitation of this method led to more accurate deduction of the molecular structures of polymer bioconjugates. Information obtained using this technique can improve macromolecular engineering design principles and better understand multivalent macromolecular interactions in biological systems. PMID:22794081

  6. Intrinsic magnetic properties of Sm2Fe17-xMxNy/Cy (M=Al, Ga or Si)

    International Nuclear Information System (INIS)

    Kubis, M.; Eckert, D.; Gebel, B.; Mueller, K.-H.; Schultz, L.

    2000-01-01

    Curie temperature T c , saturation polarization J s and anisotropy field H a of Sm 2 Fe 17-x M x N y /C y with M=Al, Ga or Si (x≤3, y∼3) were determined by thermomagnetic measurements and a numerical fitting procedure of demagnetization curves. An increasing amount of the substitutional element M leads to an increase of T c of the Sm 2 Fe 17-x M x parent compounds and generally to a decrease of T c , J s and H a for the interstitial nitrides and carbides. However, for small M contents, x≤1, an increased H a was observed compared to the substitution-free interstitial compounds. Gas-carburized and melt-carburized Sm 2 Fe 15 Ga 2 C y samples showed large differences in J s and H a but identical T c values

  7. Regresso às origens: pistas para a construção do bem e do mal

    Directory of Open Access Journals (Sweden)

    Miguel Ângelo Rodrigues Fernandes

    2011-01-01

    Full Text Available Nowadays, divisions still impose themselves. One of those divisions has become particularly relevant in contemporary culture. On one side, the Axis of Good. On the other, the Axis of Evil. In between both ends, conflicts for power. That dualism and those conflicts, building blocks of the process of constructing cultural identities, being contemporary, find part of their history in discourses of old, of which Christianity is a part. / Atualmente, as divisões continuam a impor-se. Uma dessas divisões tornou-se particularmente pregnante na cultura contemporânea. De um lado, o Eixo do Bem. Do outro, o Eixo do Mal. Mediando os dois polos, conflitos de poder. Esse dualismo e esses conflitos, constituintes do processo de construção de identidades culturais, ainda que contemporâneos, encontram parte da sua história em discursos antigos, que o Cristianismo integra.

  8. Viveret Patrick, 2005, Pourquoi ça ne va pas plus mal?, Fayard, 264 p.

    Directory of Open Access Journals (Sweden)

    Fabien Thurette

    2008-05-01

    Full Text Available Patrick Viveret est philosophe de formation et Conseiller-maître à la Cour des comptes. Il a, en outre, été chargé d’une mission, confiée par l'éphémère Secrétaire d'État à l'économie solidaire Guy Hascoët, puis prolongée par le Président Chirac sur une « autre approche de la richesse », dont le rapport final a été publié sous le titre Reconsidérer la richesse (2004.Dans son essai Pourquoi ça ne va pas plus mal ? publié en 2005, Patrick Viveret nous livre une analyse philosophique sur le « m...

  9. Ganándole la batalla al mal humor. Una propuesta didáctica

    Directory of Open Access Journals (Sweden)

    Sarah Díaz García

    2012-01-01

    Full Text Available En los últimos años, el aprendizaje de lenguas extranjeras ha llegado a ser una necesidad real tanto profesional como personal para todos nosotros como ciudadanos y como trabajadores. La enseñanza del español como lengua extranjera, que es el área de estudio en el que nos centraremos en el resto del presente artículo, ha evolucionado a medida que nuestra sociedad ha ido cambiando y adaptándose a los nuevos tiempos. Este cambio surgió con el Marco Común Europeo de Referencia para las Lenguas (MCER; pasamos de darle una máxima importancia a los aspectos puramente lingüísticos a abrirnos al hecho de que aprender un segundo idioma no es solo centrarnos en la gramática. La competencia comunicativa, por ejemplo, ha ido cobrando protagonismo en los últimos años; la idea de que un estudiante solo es competente en el uso de una lengua cuando utiliza la lingüística (pensemos en la gramática de forma correcta y siguiendo la norma ha caído en desaprobación para muchos. La realidad es que para que un alumno se considere competente en el uso de otra lengua que no sea la suya debe saber utilizar las técnicas y recursos pertinentes para poder comunicarse efectivamente con su interlocutor en un contexto real de habla.

  10. Malestar y autobiografía = Mal-estar e autobiografia

    Directory of Open Access Journals (Sweden)

    Caballé, Anna

    2013-01-01

    Full Text Available O artigo aborda o modo como os avanços no campo da neurociência estão repercutindo nos estudos sobre a autobiografia, que se beneficiam de aportes sobre o funcionamento da memória (muito simplificada em relação ao sustentado pela psicologia cognitiva e da identidade (ou Self. A ideia é de que a identidade reside primeiro no corpo e só depois na mente. O artigo privilegia algumas contribuições literárias recentes (Vicente Verdú, Marcos Ordóñez, Javier Pérez Andújar cuja escrita, abertamente autobiográfica, se vincula à experiência do corpo e às suas alterações. Isso sugere uma concepção fraturada da autobiografia como sendo a mais sintonizada com os tempos atuais, quando a narração compacta do ser parece impossível

  11. The method of producing climate change datasets impacts the resulting policy guidance and chance of mal-adaptation

    Directory of Open Access Journals (Sweden)

    Marie Ekström

    2016-12-01

    Full Text Available Impact, adaptation and vulnerability (IAV research underpin strategies for adaptation to climate change and help to conceptualise what life may look like in decades to come. Research draws on information from global climate models (GCMs though typically post-processed into a secondary product with finer resolution through methods of downscaling. Through worked examples set in an Australian context we assess the influence of GCM sub-setting, geographic area sub-setting and downscaling method on the regional change signal. Examples demonstrate that choices impact on the final results differently depending on factors such as application needs, range of uncertainty of the projected variable, amplitude of natural variability, and size of study region. For heat extremes, the choice of emissions scenario is of prime importance, but for a given scenario the method of preparing data can affect the magnitude of the projection by a factor of two or more, strongly affecting the indicated adaptation decision. For catchment level runoff projections, the choice of emission scenario is less dominant. Rather the method of selecting and producing application-ready datasets is crucial as demonstrated by results with opposing sign of change, raising the real possibility of mal-adaptive decisions. This work illustrates the potential pitfalls of GCM sub-sampling or the use of a single downscaled product when conducting IAV research. Using the broad range of change from all available model sources, whilst making the application more complex, avoids the larger problem of over-confidence in climate projections and lessens the chance of mal-adaptation.

  12. Light fractionation increases the efficacy of ALA-PDT but not of MAL-PDT: What is the role of (vascular) endothelial cells?

    Science.gov (United States)

    de Bruijn, H. S.; de Vijlder, H. C.; de Haas, E. R. M.; van der Ploeg-van den Heuvel, A.; Kruijt, B.; Poel-Dirks, D.; Sterenborg, H. J. C. M.; ten Hagen, T. L. M.; Robinson, D. J.

    2009-06-01

    Photodynamic therapy (PDT) using protoporpyrin IX (PpIX) precursors like 5-aminolevulinic acid (ALA) or methyl-aminolevulinate (MAL) has shown to be effective in the treatment of various skin diseases. Using ALA we have shown in numerous studies a significantly improved efficacy by applying light fractionation with a long dark interval. In contrast, in the hairless mouse model, the PDT efficacy using MAL is unaffected by adopting this approach. More acute edema is found after ALA-PDT suggesting a difference in response of endothelial cells to PDT. To investigate the role of endothelial cells, cryo-sections of hairless mouse skin after 4 hours of topical MAL or ALA application were stained with a fluorescent endothelial cell marker (CD31). Co-localization of this marker with the PpIX fluorescence was performed using the spectral imaging function of the confocal microscope. We have also used intra-vital confocal microscopy to image the PpIX fluorescence distribution in correlation with the vasculature of live mouse skin. Our results show PpIX fluorescence at depth in cryo-sections of mouse skin after 4 hours of topical application. Co-localization has shown to be difficult due to the changes in tissue organization caused by the staining procedure. As expected we found high PpIX fluorescence levels in the epidermis after both MAL and ALA application using intra-vital microscopy. After ALA application more PpIX fluorescence was found deep in the dermal layer of the skin than after MAL. Furthermore we detected localized fluorescence in unidentified structures that could not be correlated to blood vessels or nerves.

  13. Eletromiografia laríngea e análise vocal em pacientes com Mal de Parkinson: estudo comparativo Laryngeal electromyography and acoustic voice analysis in Parkinson's disease: a comparative study

    Directory of Open Access Journals (Sweden)

    Ana Paula Zarzur

    2010-02-01

    Full Text Available A doença ou Mal de Parkinson se deve à deficiência dopaminérgica nos núcleos da base que geram alterações motoras. Comprometimento da comunicação verbal ocorre em 70 a 90% dos doentes. Existem poucas referências da aplicação da eletromiografia no estudo dos músculos laríngeos em pacientes com a doença de Parkinson. OBJETIVOS: Definir o padrão contrátil da musculatura intrínseca da laringe e sua correlação com a análise acústica vocal nos parkinsonianos. CASUÍSTICA E MÉTODO: Estudo prospectivo onde 26 adultos com o diagnóstico de Mal de Parkinson foram submetidos à eletromiografia laríngea e análise acústica vocal. Foram coletados potenciais de ação, tanto em repouso vocal quanto em fonação. Para a análise acústica da voz foram utilizados os programas VOXMETRIA® e GRAM 5.1.6®. RESULTADOS: O padrão eletromiográfico predominante no grupo estudo foi o de hipercontratibilidade (ou recrutamento aumentado durante repouso vocal que ocorreu em 73% dos indivíduos, sem que houvesse registro eletromiográfico de tremor. Quanto às características vocais, detectou-se a presença de tremor vocal no traçado do espectrograma (VOXMETRIA E GRAM e na avaliação perceptivo-auditiva em 69,5 % e 61 % dos sujeitos, respectivamente. CONCLUSÃO: O tremor vocal foi a característica acústica predominante no grupo estudado, sem que houvesse correlação eletromiográfica.Parkinson's disease (PD involves a progressive depletion of dopamine in the basal ganglia leading to motor alterations. Oral communication impairment occurs in 75% to 90% of patients and has been poorly studied. AIM: to asses laryngeal electromyography (LEMG patterns and correlate them to vocal analysis in patients with Parkinson's disease. MATERIALS AND METHODS: This is a prospective study. Twenty six adults with PD underwent laryngeal electromyography. Rest and phonation potentials were analyzed. VOXMETRIA® and GRAM 5.1.6. ® were used in acoustic analysis

  14. Malaria epidemics in Europe after the First World War: the early stages of an international approach to the control of the disease Malária epidêmica na Europa após a Primeira Guerra Mundial: estágios iniciais de uma abordagem internacional de controle da doença

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    Gabriel Gachelin

    2011-06-01

    Full Text Available The severity and endemicity of malaria declined gradually in Europe until WWI. During and after the war, the number of malaria cases increased substantially and peaked in 1922-1924. This prompted the Hygiene Commission of the League of Nations to establish a Malaria Commission in 1923 to define the most efficient anti-malaria procedures. Additionally, between 1924 and 1930 there were several international meetings and collaborations concerning malaria, which involved the main institutes of parasitology and the Rockefeller Foundation. The Commission reports, the guidelines for anti-malaria campaigns and the scientific programs which came out of these meetings and collaborations are analyzed in the present paper.Antes da Segunda Guerra Mundial, a severidade e endemicidade da malária diminuíram gradualmente na Europa. Durante e após a guerra, o número de casos cresceu substancialmente, chegando ao máximo entre 1922 e 1924. Isso fez com que a Comissão de Higiene da Liga das Nações estabelecesse, em 1923, a Comissão de Malária, para definir procedimentos mais eficazes contra a doença. Entre 1924 e 1930 encontros e colaborações internacionais, nos quais estiveram envolvidos os principais intitutos de parasitologia e a Fundação Rockefeller, discutiram a enfermidade. Os relatórios da Comissão, as diretrizes para campanhas antimaláricas e os programas científicos decorrentes desses encontros e colaborações são analisados no artigo.

  15. Ganándole la batalla al mal humor. Una propuesta didáctica

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    Sarah Díaz García

    2012-08-01

    Full Text Available En los últimos años, el aprendizaje de lenguas extranjeras ha llegado a ser una necesidad real tanto profesional como personal para todos nosotros como ciudadanos y como trabajadores. La enseñanza del español como lengua extranjera, que es el área de estudio en el que nos centraremos en el resto del presente artículo, ha evolucionado a medida que nuestra sociedad ha ido cambiando y adaptándose a los nuevos tiempos. Este cambio surgió con el Marco Común Europeo de Referencia para las Lenguas (MCER;[1] pasamos de darle una máxima importancia a los aspectos puramente lingüísticos a abrirnos al hecho de que aprender un segundo idioma no es solo centrarnos en la gramática. La competencia comunicativa, por ejemplo, ha ido cobrando protagonismo en los últimos años; la idea de que un estudiante solo es competente en el uso de una lengua cuando utiliza la lingüística (pensemos en la gramática de forma correcta y siguiendo la norma ha caído en desaprobación para muchos. La realidad es que para que un alumno se considere competente en el uso de otra lengua que no sea la suya debe saber utilizar las técnicas y recursos pertinentes para poder comunicarse efectivamente con su interlocutor en un contexto real de habla. [1] El Marco Común Europeo de Referencia para las Lenguas surgía en el año 2001. Desde entonces la enseñanza y el aprendizaje de lenguas extranjeras dio un cambio radical respecto a la metodología y la evaluación.

  16. Fertilizantes e espaçamento entre plantas na produtividade da couve-da-Malásia Fertilizers and spacing between plants in the yield of Malaysian cabbage

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    Wanessa Resende Ferreira

    2002-12-01

    Full Text Available As brássicas têm sido objeto constante de pesquisa devido à sua importância na alimentação humana, seja pela quantidade consumida, pelo alto valor nutricional ou por sua elevada produtividade. Brassica chinensis var. parachinensis foi introduzida no Brasil, Uberlândia, em 1992, destacando-se em relação a outras brássicas por seu alto teor de vitaminas A e C, cálcio e ferro, estando pronta para consumo em aproximadamente 30 dias. A produtividade biológica e agronômica dessa variedade foi analisada utilizando-se três tipos de fertilizantes e três espaçamentos entre plantas, visando subsidiar sua produção em escala comercial. A área foliar, massa da matéria seca e taxa de crescimento absoluto foram significativamente maiores com adubação mineral em relação à adubação orgânica. Os maiores valores referentes à taxa de crescimento relativo e taxa assimilatória líquida foram registrados em plantas mantidas nos maiores espaçamentos (30x20 e 30x30 cm. A maior produtividade agronômica foi alcançada no menor espaçamento (30x10 cm, com adubação mineral, sendo registrados 21,5 t ha-1, valor muito próximo ao registrado na Malásia e China onde essa hortaliça é cultivada em larga escala.Brassica crops have been widely studied due to their importance as food for human consumption, especially in relation to their nutritional value. Both yield and consumption are high. Brassica chinensis var. parachinensis was introduced in Brazil, in Uberlândia, in 1992, surpassing other Brassica due to its high content of vitamins A and C, calcium and iron, and being ready for consumption in about 30 days. The biological and agronomic yield of this variety was analyzed under three kinds of fertilizers and three spacings between plants with a view to its production on a commercial scale. The leaf area, dry matter mass, and absolute growth rate were higher with mineral than organic fertilizer. High values for relative growth rate and net

  17. First successful reduction of clinical allergenicity of food by genetic modification: Mal d 1-silenced apples cause fewer allergy symptoms than the wild-type cultivar.

    Science.gov (United States)

    Dubois, A E J; Pagliarani, G; Brouwer, R M; Kollen, B J; Dragsted, L O; Eriksen, F D; Callesen, O; Gilissen, L J W J; Krens, F A; Visser, R G F; Smulders, M J M; Vlieg-Boerstra, B J; Flokstra-de Blok, B J; van de Weg, W E

    2015-11-01

    Genetic modification of allergenic foods such as apple has the potential to reduce their clinical allergenicity, but this has never been studied by oral challenges in allergic individuals. We performed oral food challenges in 21 apple-allergic individuals with Elstar apples which had undergone gene silencing of the major allergen of apple, Mal d 1, by RNA interference. Downregulation of Mal d 1 gene expression in the apples was verified by qRT-PCR. Clinical responses to the genetically modified apples were compared to those seen with the wild-type Elstar using a visual analogue scale (VAS). Gene silencing produced two genetically modified apple lines expressing Mal d 1.02 and other Mal d 1 gene mRNA levels which were extensively downregulated, that is only 0.1-16.4% (e-DR1) and 0.2-9.9% (e-DR2) of those of the wild-type Elstar, respectively. Challenges with these downregulated apple lines produced significantly less intense maximal symptoms to the first dose (Vmax1) than with Elstar (Vmax1 Elstar 3.0 mm vs 0.0 mm for e-DR1, P = 0.017 and 0.0 mm for e-DR2, P = 0.043), as well as significantly less intense mean symptoms per dose (meanV/d) than with Elstar (meanV/d Elstar 2.2 mm vs 0.2 mm for e-DR1, P = 0.017 and 0.0 mm for e-DR2, P = 0.043). Only one subject (5%) remained symptom-free when challenged with the Elstar apple, whereas 43% did so with e-DR1 and 63% with e-DR2. These data show that mRNA silencing of Mal d 1 results in a marked reduction of Mal d 1 gene expression in the fruit and reduction of symptoms when these apples are ingested by allergic subjects. Approximately half of the subjects developed no symptoms whatsoever, and virtually all subjects wished to consume the apple again in the future. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. Investe em mim se queres que fique! : desenvolvimento de competências como redutor das intenções de saída da organização

    OpenAIRE

    Moreira, Ana Maria da Palma

    2018-01-01

    Tese de Doutoramento em Psicologia na área de especialidade de Psicologia Social e das Organizações Nos tempos atuais, em que o mercado laboral se tornou extremamente competitivo, um dos principais problemas que se levanta às organizações é a retenção dos seus melhores colaboradores, ou seja, do seu melhor capital humano, capital humano esse muitas vezes difícil de imitar e de substituir. Acresce ainda que neste momento trabalham nas organizações colaboradores que pertencem a diferentes ge...

  19. NOS3 Polymorphisms and Chronic Kidney Disease

    Directory of Open Access Journals (Sweden)

    Alejandro Marín Medina

    2018-05-01

    Full Text Available ABSTRACT Chronic kidney disease (CKD is a multifactorial pathophysiologic irreversible process that often leads to a terminal state in which the patient requires renal replacement therapy. Most cases of CKD are due to chronic-degenerative diseases and endothelial dysfunction is one of the factors that contribute to its pathophysiology. One of the most important mechanisms for proper functioning of the endothelium is the regulation of the synthesis of nitric oxide. This compound is synthesized by the enzyme nitric oxide synthase, which has 3 isoforms. Polymorphisms in the NOS3 gene have been implicated as factors that alter the homeostasis of this mechanism. The Glu298Asp polymorphisms 4 b/a and -786T>C of the NOS3 gene have been associated with a more rapid deterioration of kidney function in patients with CKD. These polymorphisms have been evaluated in patients with CKD of determined and undetermined etiology and related to a more rapid deterioration of kidney function.

  20. Buddha and tiger; Mal Buddha, mal Tiger

    Energy Technology Data Exchange (ETDEWEB)

    Schott, Christina

    2010-02-15

    Thailand is foremost in renewable energy in South East Asia, and the country is planning to extend its capacities in this field. At the same time, the country dreams of atomic energy and also pushes doubtful megascale projects in its neighbouring countries. (orig.)

  1. Contribuição ao estudo do mal de cadeiras na Ilha de Marajó

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    Geth Jansen

    1941-01-01

    Full Text Available Como resultado de inspeções feitas à ilha de Marajó o autor assinala: 1º O mal de cadeiras continua existindo na ilha de Marajó sob a forma enzoótica, ao contrário do que pensavam os criadores, julgando-o extinto. As doenças designadas por estes como "barriga inchada" e "mormo seco", responsaveis pela grande mortalidade dos equinos, foram identificadas pelo autor como tal de cadeiras. 2º O autor considera indispensável para a pesquisa do trypanosoma o processo de inoculação em animais de laboratório, tendo utilizado para esse fim camondongos e ratos brancos. 3º Os surtos epizoóticos anuais coincidem com a época das chuvas, ocasião em que surgem os insetos hematófagos, o que faz pensar no papel desses últimos como transmissores. 4º Os cavalos podem atravessar o ano com trypanosomas no sangue e em estado de saude aparente, constituindo assim depositários do mal de cadeiras. 5º O extermínio da capivara, em consequência do seu aproveitamento econômico não modificou o carater endêmico da doença na ilha de Marajó. 6º O autor observou que os trypanosomas no tubo digestivo de Stomoxys e Tabanideos, ao cabo de 8 horas, apresentavam com movimentos diminuidos e em formas arrendondadas, não conseguindo inoculações positivas com esse material. 7º A saliva de um morcego do gênero Desmodus, que se infectou no laboratório, alimentando-se em animal doente, colhida de modo a evitar lesões da mucosa e consequente contaminação pelos trypanosomas do sangue circulante, mostrou-se incapaz de infectar, por inoculação, animais sensiveis. Este mesmo morcego não transmitiu a doença a um cão, o qual sugou durante 80 dias. Recentemente (1941 empregando um exemplar do gênero Desmodus, também infectado experimentalmente por alimentação em animal de laboratório, conseguimos transmitir o Trypanosoma equinum a uma cobaia normal. Este assunto será ventilado posteriormente.

  2. Saga do computador mal-amado Saga del ordenador malamado Saga of the unloved computer

    Directory of Open Access Journals (Sweden)

    Claudio de Moura Castro

    2010-09-01

    Full Text Available O que a tecnologia tem a oferecer para a educação é cada vez mais abundante, criativo e confiável. Seja nas tecnologias de imagem, nos computadores e nas suas combinações, a oferta é quase ilimitada. Não obstante, as escolas acadêmicas não conseguem usar com sucesso tais recursos. Há ampla evidência de que iniciativas bem focalizadas mostram resultados muito positivos. Contudo, tais sucessos não se generalizam e a maioria dos estudos mostra resultados pífios para os sistemas educativos como um todo. A sociologia da escola acadêmica e a tecnologia se enfrentam em batalhas em que saem perdendo os alunos. Não obstante, os computadores nas casas dos alunos tendem a melhorar o seu rendimento. Ainda mais admirável, a miríade de soluções educativas não-formais fazem excelente uso de todas as tecnologias.Lo que la tecnología tiene para ofrecerle a la educación es cada vez más amplio, creativo y confiable. La oferta es casi ilimitada, ya sea en tecnología de imagen, en variedad de ordenadores (computadoras o en sus diversas combinatorias. Sin embargo, los centros académicos no logran utilizarlos en forma exitosa. Hay amplia evidencia de que cuando las iniciativas están bien focalizadas resultan beneficiosas para los estudiantes. El problema es que tales resultados no se generalizan en los sistemas educativos. La consecuencia es que no mejora el rendimiento de los estudiantes. Es como si la sociología de la escuela estuviera en guerra con la tecnología. Por supuesto, los que pierden son los estudiantes. Pero, cuando los ordenadores están en los hogares de los estudiantes, su aprendizaje puede mejorar. Y más loable aún es que la educación no formal impulsa la tecnología educativa con gran éxito.What technology has to offer to education is ever more abundant, creative and reliable. Be it in the image technology, in the computers and in their combinations, the possibilities are almost endless. Nevertheless, academic schools

  3. SUPERVISION IMPLEMENTATION IN MANAGEMENT QUALITY: AN ATTEMPT TO IMPROVE THE QUALITY OF LEARNING AT MADRASAH ALIYAH DARUL A’MAL METRO

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    Subandi Subandi

    2016-03-01

    Full Text Available The primary purpose of this qualitative study is to identify and analyze supervision by implementing management quality to improve the quality of learning at Madrasah Aliyah Darul A’mal Metro, Lampung. The quality of management implementation is elaborated in the steps of assurance of learning quality. Two instruments, which consist of observation and questionnaire, were used in this study of which each instrument was analyzed based the deductive framework. The results of this study from each instrument revealed four steps of assurance of learning quality, among others (1 by socializing academic supervision program and its advantages to all stake holders, and (2 by implementing stages of assurance through academic supervision by the principals of Madrasah Aliyah Darul A’mal and supervisor, (3 performing supervision that is equipped with valid instrument to measure learning success, (4 performing the follow-up program by clinical and group discussion to provide appropriate model of performance.

  4. Crystallization, data collection and data processing of maltose-binding protein (MalE) from the phytopathogen Xanthomonas axonopodis pv. citri

    International Nuclear Information System (INIS)

    Souza, C. S.; Ferreira, L. C. S.; Thomas, L.; Barbosa, J. A. R. G.; Balan, A.

    2009-01-01

    The Xanthomonas axonopodis pv. citri maltose-binding protein MalE has been crystallized at 293 K using the hanging-drop vapour-diffusion method. Maltose-binding protein is the periplasmic component of the ABC transporter responsible for the uptake of maltose/maltodextrins. The Xanthomonas axonopodis pv. citri maltose-binding protein MalE has been crystallized at 293 K using the hanging-drop vapour-diffusion method. The crystal belonged to the primitive hexagonal space group P6 1 22, with unit-cell parameters a = 123.59, b = 123.59, c = 304.20 Å, and contained two molecules in the asymetric unit. It diffracted to 2.24 Å resolution

  5. Low shear stress induces vascular eNOS uncoupling via autophagy-mediated eNOS phosphorylation.

    Science.gov (United States)

    Zhang, Jun-Xia; Qu, Xin-Liang; Chu, Peng; Xie, Du-Jiang; Zhu, Lin-Lin; Chao, Yue-Lin; Li, Li; Zhang, Jun-Jie; Chen, Shao-Liang

    2018-05-01

    Uncoupled endothelial nitric oxide synthase (eNOS) produces O 2 - instead of nitric oxide (NO). Earlier, we reported rapamycin, an autophagy inducer and inhibitor of cellular proliferation, attenuated low shear stress (SS) induced O 2 - production. Nevertheless, it is unclear whether autophagy plays a critical role in the regulation of eNOS uncoupling. Therefore, this study aimed to investigate the modulation of autophagy on eNOS uncoupling induced by low SS exposure. We found that low SS induced endothelial O 2 - burst, which was accompanied by reduced NO release. Furthermore, inhibition of eNOS by L-NAME conspicuously attenuated low SS-induced O 2 - releasing, indicating eNOS uncoupling. Autophagy markers such as LC3 II/I ratio, amount of Beclin1, as well as ULK1/Atg1 were increased during low SS exposure, whereas autophagic degradation of p62/SQSTM1 was markedly reduced, implying impaired autophagic flux. Interestingly, low SS-induced NO reduction could be reversed by rapamycin, WYE-354 or ATG5 overexpression vector via restoration of autophagic flux, but not by N-acetylcysteine or apocynin. eNOS uncoupling might be ascribed to autophagic flux blockade because phosphorylation of eNOS Thr495 by low SS or PMA stimulation was also regulated by autophagy. In contrast, eNOS acetylation was not found to be regulated by low SS and autophagy. Notably, although low SS had no influence on eNOS Ser1177 phosphorylation, whereas boosted eNOS Ser1177 phosphorylation by rapamycin were in favor of the eNOS recoupling through restoration of autophagic flux. Taken together, we reported a novel mechanism for regulation of eNOS uncoupling by low SS via autophagy-mediated eNOS phosphorylation, which is implicated in geometrical nature of atherogenesis. Copyright © 2018 Elsevier B.V. All rights reserved.

  6. Lower expression of CADM1 and higher expression of MAL in Merkel cell carcinomas are associated with Merkel cell polyomavirus infection and better prognosis.

    Science.gov (United States)

    Iwasaki, Takeshi; Matsushita, Michiko; Nonaka, Daisuke; Nagata, Keiko; Kato, Masako; Kuwamoto, Satoshi; Murakami, Ichiro; Hayashi, Kazuhiko

    2016-02-01

    Merkel cell carcinoma (MCC) is a clinically aggressive neuroendocrine skin cancer; 80% of the cases are associated with the Merkel cell polyomavirus (MCPyV). We previously reported that MCPyV-negative MCCs have more irregular nuclei with abundant cytoplasm and significantly unfavorable outcomes than do MCPyV-positive MCCs. These results suggest that some cell adhesion or structural stabilization molecules are differently expressed depending on MCPyV infection status. Thus, we investigated the association of prognosis or MCPyV infection status in MCCs with cell adhesion molecule 1 (CADM1)/differentially expressed in adenocarcinoma of the lung protein 1 (DAL-1)/membrane protein, palmitoylated 3 (MPP3) tripartite complex and mal T-cell differentiation protein (MAL) expression, which play important roles in cell adhesion and oncogenesis and are related to cancer outcomes in various malignancies, to elucidate the role of these molecules. We analyzed the pathological and molecular characteristics of 26 MCPyV-positive and 15 MCPyV-negative MCCs. Univariate Cox regression analysis showed that advanced age (hazard ratio [HR], 8.249; P = .007) and high CADM1 expression (HR, 5.214; P = .012) were significantly unfavorable overall survival parameters, whereas MCPyV infection (HR, 0.043, P Merkel cells expressed DAL-1 and MAL but not CADM1. This study revealed that MCPyV-negative MCCs significantly expressed higher CADM1 and lower MAL than MCPyV-positive MCCs; these expression levels were markedly related to unfavorable outcomes. These data will give us important insights to develop novel molecular target therapies for MCCs. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Efeito de ação educativa participativa no conhecimento de professores do ensino básico sobre malária

    Directory of Open Access Journals (Sweden)

    Martha Cecilia Suárez-Mutis

    2011-10-01

    Full Text Available OBJETIVO: Descrever uma estratégia educativa participativa de construção de conhecimentos relacionados à malária entre professores em um município altamente endêmico. MÉTODOS: Foi feito um estudo observacional. Um curso de 40 horas foi realizado sob enfoque multidisciplinar e problematizador para 46 professores, prioritariamente da área rural, no município de Barcelos, AM, em 2008. O processo educativo participativo incluiu oficinas e aulas práticas. Para investigar os conhecimentos, aplicou-se um questionário previamente validado, antes e após o curso, avaliado por abordagens quantitativa e qualitativa usando a análise temática para respostas abertas. RESULTADOS: Previamente ao curso, os professores tinham pouca informação sobre os mecanismos de transmissão, meios de prevenção e a associação da malária aos seus vetores, bem como conceitos restritos sobre saúde. Após o curso, não somente aumentou o conhecimento dos professores sobre a malária como também emergiram reflexões sobre o papel do professor na sociedade. CONCLUSÕES: O efeito da ação educativa na construção de um saber contextualizado sobre malária e saúde indica o potencial da estratégia desenvolvida. Processos de educação permanente são necessários à sustentabilidade dos novos saberes e práticas, orientados pela promoção da saúde.

  8. Dos aspectos a considerar en la adopción de embriones en el Estado de Querétaro: el derecho del menor a conocer su origen genético y la prohibición implícita de los diagnósticos genéticos preimplantacional y prenatal

    Directory of Open Access Journals (Sweden)

    Miguel Ángel León Ortiz

    2017-01-01

    Full Text Available La donación de embriones supernumerarios en la implementación de procedimientos de reproducción asistida de naturaleza heteróloga, es una constante en las normativas vigentes en esta materia. En México, el Estado de Querétaro regula de forma particular este acto jurídico, importante en las relaciones sostenidas en el derecho de familia actual, poniendo al alcance de parejas infértiles la posibilidad de acudir a la adopción de embriones supernumerarios. En este trabajo, se analizan dos aspectos esenciales: el derecho del menor a conocer su origen genético y la prohibición implícita de los diagnósticos genéticos preimplantacional y prenatal, de donde resultan efectos jurídicos diversos.

  9. Geography, population, demography, socioeconomic, anthropometry, and environmental status in the MAL-ED cohort and case-control study Sites in Fortaleza, Ceará, Brazil.

    Science.gov (United States)

    Lima, Aldo A M; Oriá, Reinaldo B; Soares, Alberto M; Filho, José Q; de Sousa, Francisco; Abreu, Cláudia B; Bindá, Alexandre; Lima, Ila; Quetz, Josiane; Moraes, Milena; Maciel, Bruna; Costa, Hilda; Leite, Alvaro M; Lima, Noélia L; Mota, Francisco S; Di Moura, Alessandra; Scharf, Rebecca; Barrett, Leah; Guerrant, Richard L

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort in the study's Fortaleza, Brazil, catchment area has a population of approximately 82 300 inhabitants. Most of the households (87%) have access to clean water, 98% have electricity, and 69% have access to improved toilet/sanitation. Most childbirths occur at the hospital, and the under-5 mortality rate is 20 per 1000 live births. The MAL-ED case-control study population, identified through the Institute for the Promotion of Nutrition and Human Development (IPREDE), serves 600 000 inhabitants from areas totaling about 42% of the city of Fortaleza. IPREDE receives referrals from throughout the state of Ceará for infant nutrition, and provides services including teaching activities and the training of graduate students and health professionals, while supporting research projects on child nutrition and health. In this article, we describe the geographic, demographic, socioeconomic, anthropometric, and environmental status of the MAL-ED cohort and case-control study populations in Fortaleza, Brazil. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  10. Transglycosylation properties of maltodextrin glucosidase (MalZ) from Escherichia coli and its application for synthesis of a nigerose-containing oligosaccharide

    Energy Technology Data Exchange (ETDEWEB)

    Song, Kyung-Mo [Center for Agricultural Biomaterials and Department of Food Science and Biotechnology, Seoul National University, Seoul 151-921 (Korea, Republic of); Shim, Jae-Hoon [Department of Biology, University of Incheon, Incheon 406-772 (Korea, Republic of); Park, Jong-Tae; Kim, Sung-Hee [Center for Agricultural Biomaterials and Department of Food Science and Biotechnology, Seoul National University, Seoul 151-921 (Korea, Republic of); Kim, Young-Wan [Department of Food and Biotechnology, Korea University, Jochiwon 339-700 (Korea, Republic of); Boos, Winfried [Department of Biology, University of Konstanz, Konstanz 78457 (Germany); Park, Kwan-Hwa, E-mail: parkkh@incheon.ac.kr [Department of Biology, University of Incheon, Incheon 406-772 (Korea, Republic of)

    2010-06-18

    The transglycosylation reaction of maltodextrin glucosidase (MalZ) cloned and purified from Escherichia coli K12 was characterized and applied to the synthesis of branched oligosaccharides. Purified MalZ preferentially catalyzed the hydrolysis of maltodextrin, {gamma}-cyclodextrin (CD), and cycloamylose (CA). In addition, when the enzyme was incubated with 5% maltotriose (G3), a series of transfer products were produced. The resulting major transfer products, annotated as T1, T2, and T3, were purified and their structures were determined by TLC, MALDI-TOF/MS, {sup 13}C NMR, and enzymatic analysis. T1 was identified as a novel compound, maltosyl {alpha}-1,3-maltose, whereas T2 and T3 were determined to be isopanose and maltosyl-{alpha}-1,6-maltose, respectively. These results indicated that MalZ transferred sugar moiety mainly to C-3 or C-6-OH of glucose of the acceptor molecule. To obtain highly concentrated transfer products, the enzyme was reacted with 10% liquefied cornstarch, and then glucose and maltose were removed by immobilized yeast. The T1 content of the resulting reaction mixture reached 9.0%. The mixture of T1 containing a nigerose moiety can have an immunopotentiating effect on the human body and may be a potential functional sugar stuff.

  11. Gross Mal distribution Identification and Effect of Inlet Distributor on the Phase Holdup in a Trickle Bed Reactor Using Gamma-Ray Densitometry (GRD)

    International Nuclear Information System (INIS)

    Mohd Fitri Abdul Rahman; Alexander, V.; Al-Dahhan, M.

    2016-01-01

    Local liquid and gas mal distribution and their holdups in a packed column are difficult to identify due to multiphase properties and other design factors. Good liquid and gas flow distribution important to determine to get high performance of Trickle Bed Reactor (TBR). Gross mal distribution indicates some faulty or bad flow distribution of liquid and gas. In this work, gross mal distribution of phases has been identified using Gamma Ray Densitometry (GRD) technique with three types of inlet distributors (single inlet towards the wall, single inlet at the center, and proper shower) by measuring line average diameter profile of phases (Liquid, Gas, and Solids) holdups. Gamma-ray densitometry is a non-invasive technique which can be implemented at the laboratory, pilot plant, and industrial scales reactors. Experiments were performed on 0.14 m diameter reactor made of Plexiglas filled with 0.003 m glass bead which acts as the solid. The superficial velocities for both gas and liquid were in the range 0.03 m/s to 0.27 m/s and 0.004 m/s to 0.014 m/s respectively. Proper shower distributor showed early liquid spreading than compared with other distributors. The effect of superficial gas velocity on liquid spread was seen to be non-significant, and liquid distribution is found to be almost uniform at the center region of the catalyst bed. (author)

  12. Surto de malária por Haemoproteus columbae em pombos An outbreak of malaria by Haemoproteus columbae in pigeons

    Directory of Open Access Journals (Sweden)

    J.S. Resende

    2001-06-01

    Full Text Available Relata-se um surto de malária por Haemoproteus columbae em pombos-correio (Columba livia, caracterizado por um quadro agudo com mortalidade de 3% ao dia em aves de aspecto saudável ou crônico com prostração e fraqueza. O exame clínico das aves doentes evidenciou sinusite e conjuntivite e à necropsia traqueíte hemorrágica, aerossaculite, esplenomegalia, nefromegalia e hepatomegalia com hemorragias. O díptero hematófago da família Hippoboscidae Pseudolynchia canariensis foi encontrado inserido entre as penas dos indivíduos. Esfregaços de sangue periférico e cardíaco e impressões de baço e fígado corados por Giemsa permitiram a visualização de inclusões intraeritrocitárias características de Haemoproteus columbae

  13. Malária no Brasil: panorama epidemiológico na última década

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    Barata Rita de Cássia B.

    1995-01-01

    Full Text Available Este artigo apresenta, de maneira resumida, as principais alterações que marcaram a ocorrência de malária, no Brasil, nesta última década. Chama-se a atenção para o processo de focalização da doença, com a concentração da transmissão em áreas, relativamente restritas, da região amazônica. A mudança na situação epidemiológica acarreta a revisãoconceitual, levando ao abandono da concepção de "doença de massa" e à elaboração da teoria focal. Do mesmo modo, as ações de controle sofrem os impactos das transformações ocorridas e as tentativas de erradicação são abandonadas e substituídas por medidas de controle diversificadas e adaptadas a cada localidade. As novas propostas, oriundas da Conferência Ministerial de Amsterdam, são apresentadas e comentadas.

  14. DOENÇAS DE SUÍNOS

    OpenAIRE

    Juliana Sperotto Brum

    2013-01-01

    Esta tese envolveu o estudo de doenças de suínos, incluindo a descrição de um sarcoma granulocítico eosinofílico e surtos de intoxicação por sal. O estudo das características e frequência das doenças na população suína na região de abrangência do Laboratório de Patologia Veterinária (LPV) da Universidade Federal de Santa Maria (UFSM) foi realizado através de um estudo retrospectivo de todos os diagnósticos de necropsias. Foram separados 564 casos com diagnósticos conclusivos. A...

  15. Renal nerves and nNOS

    DEFF Research Database (Denmark)

    Kompanowska-Jezierska, Elzbieta; Wolff, Helle; Kuczeriszka, Marta

    2008-01-01

    ). This was tested by NaLoad after chronic renal denervation with and without inhibition of nNOS by S-methyl-thiocitrulline (SMTC). In addition, the acute effects of renal denervation on MABP and sodium balance were assessed. Rats were investigated in the conscious, catheterized state, in metabolic cages...... of acutely and chronically denervated rats were less than control (15% and 9%, respectively, P reduced by renal denervation (14.5 +/- 0.2 vs. 19.3 +/- 1.3 mIU/l, P reduced...... PRC (P sodium excretion six-fold, irrespective of renal denervation and SMTC. The metabolic data demonstrated that renal denervation lowered sodium balance during the first days after denervation (P

  16. iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat.

    Science.gov (United States)

    Fujii, Naoto; Meade, Robert D; Alexander, Lacy M; Akbari, Pegah; Foudil-Bey, Imane; Louie, Jeffrey C; Boulay, Pierre; Kenny, Glen P

    2016-02-01

    Nitric oxide synthase (NOS) contributes to sweating and cutaneous vasodilation during exercise in younger adults. We hypothesized that endothelial NOS (eNOS) and neuronal NOS (nNOS) mediate NOS-dependent sweating, whereas eNOS induces NOS-dependent cutaneous vasodilation in younger adults exercising in the heat. Further, aging may upregulate inducible NOS (iNOS), which may attenuate sweating and cutaneous vasodilator responses. We hypothesized that iNOS inhibition would augment sweating and cutaneous vasodilation in exercising older adults. Physically active younger (n = 12, 23 ± 4 yr) and older (n = 12, 60 ± 6 yr) adults performed two 30-min bouts of cycling at a fixed rate of metabolic heat production (400 W) in the heat (35°C). Sweat rate and cutaneous vascular conductance (CVC) were evaluated at four intradermal microdialysis sites with: 1) lactated Ringer (control), 2) nNOS inhibitor (nNOS-I, NPLA), 3) iNOS inhibitor (iNOS-I, 1400W), or 4) eNOS inhibitor (eNOS-I, LNAA). In younger adults during both exercise bouts, all inhibitors decreased sweating relative to control, albeit a lower sweat rate was observed at iNOS-I compared with eNOS-I and nNOS-I sites (all P exercise protocol (all P exercise bouts (all P > 0.05). We show that iNOS and eNOS are the main contributors to NOS-dependent sweating and cutaneous vasodilation, respectively, in physically active younger adults exercising in the heat, and that iNOS inhibition does not alter sweating or cutaneous vasodilation in exercising physically active older adults. Copyright © 2016 the American Physiological Society.

  17. Structural distortions in Sr3-xAxMO4F (A=Ca, Ba; M=Al, Ga, In) anti-Perovskites and corresponding changes in photoluminescence

    International Nuclear Information System (INIS)

    Sullivan, Eirin; Avdeev, Maxim; Vogt, Thomas

    2012-01-01

    The ordered oxyfluoride family Sr 3 − x A x MO 4 F (A=Ca, Ba and M=Al, Ga) has formed the basis of several new inorganic phosphors, and shows great potential for use in phosphor-conversion LED lamp devices. This study examines the correlation between subtle structural changes and photoluminescent behaviour in some of these materials. In order to ascertain whether cation charge compensation has any influence on structure and subsequent photoluminescent behaviour, a comparison was carried out between phases with the nominal compositions Sr 2.975 Ce 0.025 AlO 4 F and Sr 2.95 Ce 0.025 Na 0.025 AlO 4 F using structural characterisation based upon high-resolution neutron powder diffraction (NPD) data. Additionally, NPD data has been used to elucidate the role of different M cations in these materials, using Sr 2.25 Ba 0.6 Eu 0.1 M 0.95 In 0.05 O 4−α F 1−δ (M=Al, Ga) to determine the effect M cation size has on structure and photoluminescent properties. - Graphical abstract: The structure of Sr3-xAxMO4F (A=Ca, Ba and M=Al, Ga) and excitation and emission spectra for Sr 2.25 Ba 0.6 Eu 0.1 Ga 0.95 In 0.05 O 4−α F 1−δ . Highlights: ► Correlation between structural changes and photoluminescence in Sr 3−x A x MO 4 F (A=Ca, Ba, M=Al, Ga). ► Comparison of Sr 2.975 Ce 0.025 AlO 4 F and Sr 2.95 Ce 0.025 Na 0.025 AlO 4 F using high-resolution NPD. ► Study of the effect of cation charge-compensation on structure and photoluminescent behaviour. ► Examination of high-resolution NPD data for Sr 2.25 Ba 0.6 Eu 0.1 M 0.95 In 0.05 O 4−α F 1−δ (M=Al, Ga). ► Determination of the effect M cation size has on structure and photoluminescent properties.

  18. An ecosystem approach to malaria control in an urban setting Uma abordagem ecossistêmica ao controle da malária em contexto urbano

    Directory of Open Access Journals (Sweden)

    Gabriel Carrasquilla

    2001-01-01

    Full Text Available We conducted a research project aimed at strengthening local government and the community for a sustainable malaria control strategy. The project began with a baseline diagnosis of malaria prevalence, a KAP survey, entomology, and health services delivery, after which an epidemiological study was performed to identify risk factors associated with malaria, thereafter used to plan intervention measures. A program evaluation was conducted five years later. By using an ecosystem approach to reanalyze data, this paper discusses how malaria arises from a complex interaction of cultural, economic, ecological, social, and individual factors. Intervention measures require an intersectorial and transdisciplinary approach that does not exist at the moment. Health sector leadership is limited, and there is no true community participation. Implications for research, including the use of qualitative and quantitative methods, study design, and complexity of data analysis are discussed. Finally, implications for malaria control are discussed, stressing the differences between the ecosystem and integrated disease control approaches.Os autores implementaram um projeto de pesquisa voltado ao fortalecimento do governo local e da comunidade com vistas à estratégia sustentável de controle da malária. O projeto iniciou com diagnóstico prévio, incluindo prevalência da malária, entomologia, KAP (conhecimentos, atitudes e práticas e oferta de serviços de saúde; a seguir, realizou-se inquérito epidemiológico para identificar fatores de risco associados à malária e a escolha de medidas de intervenção adequadas. O programa foi avaliado após cinco anos. Ao adotar a abordagem ecossistêmica para re-analisar os dados, o artigo discute como a malária surge a partir da interação complexa entre fatores culturais, econômicos, ecológicos, sociais e individuais. Medidas de intervenção exigem abordagem intersetorial e transdisciplinar ainda não existente. A

  19. Primary health care in municipalities at high risk for malaria Atención primaria a la salud en municipios de alto riesgo para malaria Atenção primária à saúde em municípios de alto risco para malária

    Directory of Open Access Journals (Sweden)

    Ana Cristina Soares Ferreira

    2011-12-01

    Programa Nacional de Control de Malaria y la Atención Básica de un modo general.Neste estudo pretendeu-se caracterizar aspectos da Atenção Básica, na região da Amazônia Legal, principal área endêmica para malária, no Brasil. O Ministério da Saúde recomenda a expansão da Atenção Básica nas áreas malarígenas. Foi realizado inquérito transversal, aplicado aos portadores de malária, em 6 municípios, durante os meses de janeiro e fevereiro de 2007. Os dados coletados foram tabulados e analisados, utilizando-se técnicas quantitativas. Registros de campo auxiliaram na composição das impressões do contexto dessas políticas nos locais pesquisados. A qualidade do acesso a consultas e medicamentos, o vínculo com os profissionais e com as Unidades Básicas de Saúde, o sistema de referência e contrarreferência, e a abordagem familiar e comunitária da saúde pelos profissionais, nos municípios do estudo, ainda são deficientes nesse nível de atenção. Há baixa integração entre o Programa Nacional de Controle de Malária e a Atenção Básica, de modo geral.

  20. «Gente de mal vivir»: families and incorrigible sons in new Spain, 1721-1729

    Directory of Open Access Journals (Sweden)

    Cáceres Menéndez, Beatriz

    2006-08-01

    Full Text Available Forced transportation to the Philippine and Mariana Islands, a form of social exile and the equivalent of deportation, was used in New Spain to punish criminals and people judged to be undesirable. Those who were sent across the Pacific were always male and usually American-born Spaniards. Both the viceregal government and parents thought forced transportation to be an appropriate way to rid Mexico not only of criminals but also of men «of evil living» - people whose lives were dedicated to gambling, public drunkenness, idleness, and immorality. Parents, brothers, and even wives therefore used forced transportation to eliminate unwanted family members whose behavior threatened to tarnish family honor.

    En la Nueva España el traslado forzoso de individuos a las Islas Filipinas y Marianas fue una forma de exilio equivalente a la deportación para castigar a los criminales y a la gente considerada indeseable. Los condenados fueron siempre hombres y usualmente españoles nacidos en América. Tanto el gobierno virreinal como los padres de familia pensaron en el traslado forzoso como un medio apropiado para limpiar el Reino no sólo de criminales sino también de «gente de mal vivir», es decir, aquellos dedicados al juego, la embriaguez pública, la ociosidad y la inmoralidad. Padres, hermanos y aún esposas utilizaron el traslado obligado como un medio para eliminar a los familiares cuyos comportamientos amenazaban manchar el honor de la familia.

  1. Cloning and Molecular Characterization of an Alpha-Glucosidase (MalH) from the Halophilic Archaeon Haloquadratum walsbyi.

    Science.gov (United States)

    Cuebas-Irizarry, Mara F; Irizarry-Caro, Ricardo A; López-Morales, Carol; Badillo-Rivera, Keyla M; Rodríguez-Minguela, Carlos M; Montalvo-Rodríguez, Rafael

    2017-11-21

    We report the heterologous expression and molecular characterization of the first extremely halophilic alpha-glucosidase (EC 3.2.1.20) from the archaeon Haloquadratum walsbyi . A 2349 bp region ( Hqrw_2071 ) from the Hqr. walsbyi C23 annotated genome was PCR-amplified and the resulting amplicon ligated into plasmid pET28b(+), expressed in E. coli Rosetta cells, and the resulting protein purified by Ni-NTA affinity chromatography. The recombinant protein showed an estimated molecular mass of 87 kDa, consistent with the expected value of the annotated protein, and an optimal activity for the hydrolysis of α-PNPG was detected at 40 °C, and at pH 6.0. Enzyme activity values were the highest in the presence of 3 M NaCl or 3-4 M KCl. However, specific activity values were two-fold higher in the presence of 3-4 M KCl when compared to NaCl suggesting a cytoplasmic localization. Phylogenetic analyses, with respect to other alpha-glucosidases from members of the class Halobacteria, showed that the Hqr. walsbyi MalH was most similar (up to 41%) to alpha-glucosidases and alpha-xylosidases of Halorubrum . Moreover, computational analyses for the detection of functional domains, active and catalytic sites, as well as 3D structural predictions revealed a close relationship with an E. coli YicI-like alpha-xylosidase of the GH31 family. However, the purified enzyme did not show alpha-xylosidase activity. This narrower substrate range indicates a discrepancy with annotations from different databases and the possibility of specific substrate adaptations of halophilic glucosidases due to high salinity. To our knowledge, this is the first report on the characterization of an alpha-glucosidase from the halophilic Archaea, which could serve as a new model to gain insights into carbon metabolism in this understudied microbial group.

  2. Cloning and Molecular Characterization of an Alpha-Glucosidase (MalH from the Halophilic Archaeon Haloquadratum walsbyi

    Directory of Open Access Journals (Sweden)

    Mara F. Cuebas-Irizarry

    2017-11-01

    Full Text Available We report the heterologous expression and molecular characterization of the first extremely halophilic alpha-glucosidase (EC 3.2.1.20 from the archaeon Haloquadratum walsbyi. A 2349 bp region (Hqrw_2071 from the Hqr. walsbyi C23 annotated genome was PCR-amplified and the resulting amplicon ligated into plasmid pET28b(+, expressed in E. coli Rosetta cells, and the resulting protein purified by Ni-NTA affinity chromatography. The recombinant protein showed an estimated molecular mass of 87 kDa, consistent with the expected value of the annotated protein, and an optimal activity for the hydrolysis of α-PNPG was detected at 40 °C, and at pH 6.0. Enzyme activity values were the highest in the presence of 3 M NaCl or 3–4 M KCl. However, specific activity values were two-fold higher in the presence of 3–4 M KCl when compared to NaCl suggesting a cytoplasmic localization. Phylogenetic analyses, with respect to other alpha-glucosidases from members of the class Halobacteria, showed that the Hqr. walsbyi MalH was most similar (up to 41% to alpha-glucosidases and alpha-xylosidases of Halorubrum. Moreover, computational analyses for the detection of functional domains, active and catalytic sites, as well as 3D structural predictions revealed a close relationship with an E. coli YicI-like alpha-xylosidase of the GH31 family. However, the purified enzyme did not show alpha-xylosidase activity. This narrower substrate range indicates a discrepancy with annotations from different databases and the possibility of specific substrate adaptations of halophilic glucosidases due to high salinity. To our knowledge, this is the first report on the characterization of an alpha-glucosidase from the halophilic Archaea, which could serve as a new model to gain insights into carbon metabolism in this understudied microbial group.

  3. Vascular nitric oxide: Beyond eNOS

    Directory of Open Access Journals (Sweden)

    Yingzi Zhao

    2015-10-01

    Full Text Available As the first discovered gaseous signaling molecule, nitric oxide (NO affects a number of cellular processes, including those involving vascular cells. This brief review summarizes the contribution of NO to the regulation of vascular tone and its sources in the blood vessel wall. NO regulates the degree of contraction of vascular smooth muscle cells mainly by stimulating soluble guanylyl cyclase (sGC to produce cyclic guanosine monophosphate (cGMP, although cGMP-independent signaling [S-nitrosylation of target proteins, activation of sarco/endoplasmic reticulum calcium ATPase (SERCA or production of cyclic inosine monophosphate (cIMP] also can be involved. In the blood vessel wall, NO is produced mainly from l-arginine by the enzyme endothelial nitric oxide synthase (eNOS but it can also be released non-enzymatically from S-nitrosothiols or from nitrate/nitrite. Dysfunction in the production and/or the bioavailability of NO characterizes endothelial dysfunction, which is associated with cardiovascular diseases such as hypertension and atherosclerosis.

  4. Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy Relação entre as concentrações plasmáticas e eritrocitárias de quinina em crianças com malária por Plasmodium falciparum não complicada em terapia via oral

    Directory of Open Access Journals (Sweden)

    José L.F. Vieira

    2009-04-01

    Full Text Available We determined the relationship between plasma and red blood cell concentrations of quinine in children with uncomplicated falciparum malaria from an endemic area of Amazonian region. Quinine was determined by high performance liquid chromatography with ultraviolet detection. In the steady state the ratio between plasma and red blood cell quinine concentration was 1.89 ± 1.25 ranging from 1.05 to 2.34. This result demonstrated that quinine do not concentrate in red blood cell of Brazilian children and characterize the absence of interracial difference in this relationship.Neste estudo foi determinada a relação entre as concentrações plasmáticas e eritrocitárias de quinina em crianças com malária falciparum não complicada, oriundas de área endêmica da Região Amazônica. A quinina foi detrminada por cromatografia líquida de alta eficiência. No estado de equilíbrio, a relação foi 1,89 ± 1,25 variando de 1,05 a 2,34. Estes resultados demonstraram que a quinina não se concentra nos eritrócitos das crianças e caracterizaram a ausência de diferença racial nesta relação.

  5. Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy.

    Science.gov (United States)

    Kinaciyan, Tamar; Nagl, Birgit; Faustmann, Sandra; Frommlet, Florian; Kopp, Stephan; Wolkersdorfer, Martin; Wöhrl, Stefan; Bastl, Katharina; Huber, Hans; Berger, Uwe; Bohle, Barbara

    2018-03-01

    Birch pollen-related apple allergy is among the most prevalent food allergies in adolescent/adult subjects and mainly results from sensitization to the major birch pollen allergen Bet v 1 and subsequent cross-reaction with the apple protein Mal d 1. However, specific immunotherapy with birch pollen has inconsistent effects on apple allergy. We sought to compare the safety and efficacy of sublingual immunotherapy (SLIT) with 2 formulations containing either rMal d 1 or rBet v 1 on birch pollen-related apple allergy. Sixty participants with birch pollen-related apple allergy were randomized to daily sublingual application of placebo (n = 20) or 25 μg of rMal d 1 (n = 20) or rBet v 1 (n = 20) for 16 weeks. Adverse events were regularly recorded. Sublingual challenges with standardized doses of rMal d 1, skin prick tests with recombinant allergens, and measurements of allergen-specific IgE and IgG 4 antibodies were performed before and after treatment. Both formulations caused comparable, mainly local adverse events. No systemic reactions occurred. Compared with the placebo and rBet v 1-treated groups, SLIT with rMal d 1 reduced rMal d 1-induced oral symptoms (P = .001 and P = .038) accompanied by longitudinally reduced rMal d 1-specific cutaneous reactions (P = .022) and enhanced IgG 4 /IgE ratios (P = .012). SLIT with rBet v 1 neither improved the clinical reactivity to rMal d 1 nor enhanced rMal d 1-specific IgG 4 /IgE ratios. Participants receiving placebo showed no allergen-specific changes. Sublingual treatment with a recombinant food allergen was safe and clinically effective, as determined by using standardized challenges. We present a promising approach for the effective treatment of birch pollen-related apple allergy. Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  6. MosquitoMap and the Mal-area calculator: new web tools to relate mosquito species distribution with vector borne disease.

    Science.gov (United States)

    Foley, Desmond H; Wilkerson, Richard C; Birney, Ian; Harrison, Stanley; Christensen, Jamie; Rueda, Leopoldo M

    2010-02-18

    Mosquitoes are important vectors of diseases but, in spite of various mosquito faunistic surveys globally, there is a need for a spatial online database of mosquito collection data and distribution summaries. Such a resource could provide entomologists with the results of previous mosquito surveys, and vector disease control workers, preventative medicine practitioners, and health planners with information relating mosquito distribution to vector-borne disease risk. A web application called MosquitoMap was constructed comprising mosquito collection point data stored in an ArcGIS 9.3 Server/SQL geodatabase that includes administrative area and vector species x country lookup tables. In addition to the layer containing mosquito collection points, other map layers were made available including environmental, and vector and pathogen/disease distribution layers. An application within MosquitoMap called the Mal-area calculator (MAC) was constructed to quantify the area of overlap, for any area of interest, of vector, human, and disease distribution models. Data standards for mosquito records were developed for MosquitoMap. MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting. The MAC quantifies the Mal-area, i.e. the area where it is theoretically possible for vector-borne disease transmission to occur, thus providing a useful decision tool where other disease information is limited. The Mal-area approach emphasizes the independent but cumulative contribution to disease risk of the vector species predicted present. MosquitoMap adds value to, and makes accessible, the results of past collecting efforts, as well as providing a template for other arthropod spatial databases.

  7. A computational fluid dynamics and effectiveness-NTU based co-simulation approach for flow mal-distribution analysis in microchannel heat exchanger headers

    International Nuclear Information System (INIS)

    Huang, Long; Lee, Moon Soo; Saleh, Khaled; Aute, Vikrant; Radermacher, Reinhard

    2014-01-01

    Refrigerant flow mal-distribution is a practical challenge in most microchannel heat exchangers (MCHXs) applications. Geometry design, uneven heat transfer and pressure drop in the different microchannel tubes are three main reasons leading to the flow mal-distribution. To efficiently and accurately account for these three effects, a new MCHX co-simulation approach is proposed in this paper. The proposed approach combines a detailed header simulation based on computational fluid dynamics (CFD) and a robust effectiveness-based finite volume tube-side heat transfer and refrigerant flow modeling tool. The co-simulation concept is demonstrated on a ten-tube MCHX case study. Gravity effect and uneven airflow effect were numerically analyzed using both water and condensing R134a as the working fluids. The approach was validated against experimental data for an automotive R134a condenser. The inlet header was cut open after the experimental data had been collected. The detailed header geometry was reproduced using the proposed CFD header model. Good prediction accuracy was achieved compared to the experimental data. The presented co-simulation approach is capable of predicting detailed refrigerant flow behavior while accurately predicts the overall heat exchanger performance. - Highlights: •MCHX header flow distribution is analyzed by a co-simulation approach. •The proposed method is capable of simulating both single-phase and two-phase flow. •An actual header geometry is reproduced in the CFD header model. •The modeling work is experimentally validated with good accuracy. •Gravity effect and air side mal-distribution are accounted for

  8. Sobre los saberes culturales y el fenómeno "sentirse bien-sentirse mal" On cultural knowledge and the phenomenon "feel good-fell bad"

    OpenAIRE

    Virtudes Rodero Sánchez; Carme Vives Relats; Sagrario Acebedo Urdiales; Carme Ferré Grau

    2010-01-01

    El objetivo del presente estudio es identificar los saberes culturales inmersos en el fenómeno "sentirse-bien, sentirse mal", en diferentes situaciones de cuidado. Se elaboró un estudio cualitativo con un enfoque fenomenológico interpretativo, mediante el análisis de 18 narrativas a partir de entrevistas en profundidad realizadas por alumnas del Máster en Ciencias de la Enfermería en diferentes contextos de cuidados. Las categorías identificadas fueron: (1) Cronicidad y concepto de sentirse b...

  9. Estudo de dose adequada da droga RO42-1611 (Arteflene) no tratamento da malária por Plasmodium falciparum

    OpenAIRE

    SILVA, Rita do Socorro Uchôa

    1997-01-01

    A resistência crescente do P. falciparum aos antimaláricos habitualmente empregados, torna urgente a avaliação de novas drogas. O Ro 42-1611 é um antimalárico derivado da planta chinesa Arlabotrys uncinatus. Usado apenas na África em três trabalhos no tratamento da malária por P. falciparum, tem sua ação desconhecida em sul-americanos com esta doença. Apesar do efeito antimalárico ter sido comprovado, ainda não se encontrou a dose adequada para o tratamento supressivo do P. falciparum. Avalia...

  10. Mal de Montaña, migraña y depresión: Coexistencia casual o causal? Posible rol de la hipoxia ambiental.

    Directory of Open Access Journals (Sweden)

    Alberto Arregui

    1995-10-01

    Full Text Available Objetivo: Estudiar la posible asociación entre mal de montaña crónico, migraña y depresión. Material y métodos: Estudio epidemiológico realizado en setiembre de 1990en 379 hombres adultos con residencia permanente en la ciudad de Cerro de Pasco (4300 m.s.n.m.; se hicieron 15 preguntas asociadas a depresión y 9 preguntas asociadas al mal de montaña crónico (MMC con las que se calcularon puntajes de depresión y del mal de montaña crónico. Los puntajes por encima de dos desviaciones estándar de la media fueron considerados como altos. Resultados: La frecuencia de migrañas fue de 48.3% entre hombres con puntajes altos de MMC y de 26.5% entre aquellos con puntajes normales (p=0.013. El 16.7% de hombres con puntaje alto de MMC tuvo puntaje alto de depresión mientras que sólo el 6.5% con puntaje normal de MMC tuvo puntaje alto de depresión (p=0.04. El riesgo de tener puntaje alto de depresión o de MMC fue más del doble entre hombres con migrañas comparados con hombres sin migrañas. La posibilidad de tener migraña o puntajes alto de MMC, fue tres veces mayor entre hombres con puntajes alto de depresión comparados con los que tuvieron puntajes de MMC más altos que aquellos sin cefaleas o con otros tipos de cefaleas. Conclusiones: Los datos muestran una coexistencia más que casual entre estas tres entidades clínicas. Se sugiere que un factor de riesgo común a las tres sea la hipoxia crónica que podría producir cambios neuroquímicos en el cerebro que explicaría, en parte, los síntomas de estos tres síndromes. Los datos también sugieren que los síntomas subjetivos que ocurren en el mal de montaña crónico son similares a los que ocurren en la depresión. (Rev Med Hered 1996; 6: 163-167.

  11. Histopatologia da leishmaniose tegumentar por Leishmania braziliensis braziliensis. 3. Reação celular nos tecidos

    Directory of Open Access Journals (Sweden)

    Albino Verçosa de Magalhães

    1986-10-01

    Full Text Available Os A.A. analisam as alterações histopatológicas observadas em 378 casos de Leishmaniose Tegumentar da localidade de Três Braços Estado da Bahia, dos quais 307 eram de portadores de lesões exclusivamente cutâneas, 54 de portadores de lesões exclusivamnte mucosas e 17 de portadores de lesões cutâneo-mucosas. A infiltração histiolinfoplasmocitária, na maioria dos casos, parece desempenhar o papel de resposta celular inespecífica à presença de um irritante tecidual, porém, nos casos de forma mucosa, não se pode afastar a possibilidade de que esse infiltrado esteja participando de uma reação de tipo autoagressivo. O plasmócito constitui um elemento quase constante nas lesões desenvolvidas, mas não tem sido observado nas lesões residuais, quer em via de cura ou já cicatrizadas; sua presença nestes casos denota, quase sempre, tendência à recidiva. Os mastdcitos foram observados em lesões tanto da forma cutânea como da forma mucosa, mas predominavam nas primeiras. Seu número foi significantemente maior no padrão de Reação Exsudativa e Neerótico Granulomatosa, onde os fenômenos necróticos são bem desenvolvidos. Os eosinófilos apresentaram associação significativa com os mastócitos, confirmando a existência de um eixo bidirecional entre estás duas células, o qual deve participar da modulação inflamatória, na Leishmaniose Tegumentar. Dois tipos de reação granulomatosa foram observados: um desorganizado, em relação, muitas vezes, com a necrose tissular, e outro organizado, mais raro, do tipo tuberculóide. O primeiro foi interpretado como de origem pós-necrótica, surgindo com a redução da carga parasitária, propiciada pelos fenômenos necróticos: eliminado o antígeno e mantidos os níveis de anticorpos, surgem as condições necessárias ao estabelecimento do granuloma, semelhante àquele observado nas lesões por imunocomplexo em excesso de anticorpos. O outro tipo de reação foi o granuloma de c

  12. Synthesis, crystal structure and magnetic properties of [Cu(mal(abpt(H2O].3/2H2O and [Cu2(sq(abpt 2].2H2O (mal = malonate, sq = squarate, abpt = 4-amino-3,5-di-2-pyridyl-4H-1,2,4 triazole

    Directory of Open Access Journals (Sweden)

    Eno A. Ededet

    2011-04-01

    Full Text Available Two new mixed-ligand complexes of formula [Cu(mal(abpt(H2O].3/2H2O (1 and [Cu2(sq(abpt2].2H2O (2 [mal = malonate, abpt = 4-amino-3,5-di-2-pyridyl-4H-1,2,4 triazole and sq = squarate], have been prepared and characterized by X-ray crystal structure determination and magnetic studies. Complex 1 crystallizes in the monoclinic system, space group C2/c, with a = 14.0086(2 Å, b = 10.0980(2 Å, c = 25.630(4 Å; β = 97.5900(10 o, and Z = 8. Complex 2 crystallizes in the triclinic system, space group P-1 with a = 7.5696(15 Å, b = 8.4697(17 Å, c = 11.049(2 Å; β = 93.00(3o, α = 96.98(3, γ = 90.111(3 and Z = 1. Complex 1 consist of a neutral mononuclear [Cu(mal(abpt(H2O] unit and water molecule of crystallization in a distorted square pyramidal coordination sphere, while complex 2 is viewed as being made up of [Cu(sq(abpt2] units with the squarato ligand bridging the two copper(II cations. Variable temperature magnetic behaviour of the complexes reveals the existence of weak antiferromagnetic interaction for complex 1 and weak ferromagnetic intrachain interaction for complex 2.

  13. NOS CO-OPS Water Level Data, Verified, High Low

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has verified (quality-controlled), daily, high low water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and Services...

  14. NOS CO-OPS Active Currents Data, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has surface Active Currents data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These raw data have not...

  15. NOS CO-OPS Water Level Data, Verified, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has verified (quality-controlled), 6-minute, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS)....

  16. NOS CO-OPS Water Level Data, Preliminary, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has recent, preliminary (not quality-controlled), 6-minute, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and...

  17. NOS CO-OPS Meteorological Data, Relative Humidity, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Relative Humidity data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  18. NOAA NOS SOS, EXPERIMENTAL, 1853-present, Air Temperature

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have air temperature data. *These services are for testing and evaluation...

  19. NOAA NOS SOS, EXPERIMENTAL, 1853-present, Barometric Pressure

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have barometric pressure data. *These services are for testing and...

  20. NOAA NOS SOS, EXPERIMENTAL, 1853-present, Water Temperature

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have water temperature data. *These services are for testing and evaluation...

  1. NOAA/NOS and USCGS Seabed Descriptions from Hydrographic Surveys

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA/NOS and USCGS Seabed Descriptions from Hydrographic Surveys database is a compilation of surficial sediment composition from multiple sources for over...

  2. NOS CO-OPS Water Level Data, Verified, Hourly

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has verified (quality-controlled), hourly, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS)....

  3. NOS CO-OPS Meteorological Data, Rain Fall, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Rain Fall data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been...

  4. NOAA NOS SOS, EXPERIMENTAL, 1853-present, Water Level

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA NOS SOS server is part of the IOOS DIF SOS Project. The stations in this dataset have water surface height above a reference datum. *These services are for...

  5. NOS CO-OPS Meteorological Data, Wind, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Wind data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been subjected...

  6. NOS CO-OPS Meteorological Data, Air Temperature, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Air Temperature data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  7. NOS CO-OPS Meteorological Data, Visibility, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Visibility data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been...

  8. NOS CO-OPS Meteorological Data, Conductivity, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Conductivity data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not been...

  9. NOS CO-OPS Meteorological Data, Water Temperature, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Water Temperature data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  10. NOS CO-OPS Meteorological Data, Barometric Pressure, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has Barometric Pressure data from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). WARNING: These preliminary data have not...

  11. NOS CO-OPS Water Level Data, Preliminary, 1-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has recent, preliminary (not quality-controlled), 1-minute, water level (tide) data from NOAA NOS Center for Operational Oceanographic Products and...

  12. eNOS-uncoupling in age-related erectile dysfunction

    OpenAIRE

    Johnson, JM; Bivalacqua, TJ; Lagoda, GA; Burnett, AL; Musicki, B

    2011-01-01

    Aging is associated with ED. Although age-related ED is attributed largely to increased oxidative stress and endothelial dysfunction in the penis, the molecular mechanisms underlying this effect are not fully defined. We evaluated whether endothelial nitric oxide synthase (eNOS) uncoupling in the aged rat penis is a contributing mechanism. Correlatively, we evaluated the effect of replacement with eNOS cofactor tetrahydrobiopterin (BH4) on erectile function in the aged rats. Male Fischer 344 ...

  13. Malûliyet

    OpenAIRE

    Güçlü, Eda

    2014-01-01

    Bezmez, Dikmen. “Urban Citizenship, the Right to the City and Politics of Disability in Istanbul.” International Journal of Urban and Regional Research 37, no. 1 (January 2013): 93–114. Evcil, An. “Wheelchair Accessibility to Public Buildings in Istanbul.” Disability & Rehabilitation: Assistive Technology 4, no. 2 (March 2009): 76–85. Evcil, Nilay. “Designers’ Attitudes Towards Disabled People and the Compliance of Public Open Places: The Case of Istanbul.” European Planning Studies 18, no. 1...

  14. Role of iNOS and eNOS expression in a group of Egyptian diabetic and nondiabetic nephropathy patients

    Directory of Open Access Journals (Sweden)

    Mayssa I. Aly

    2013-01-01

    Conclusion The presence of iNOS is associated with tubular damage resulting in renal failure. The upregulation of NO in diabetes mellitus type 2 may explain the endothelial dysfunction that is associated with almost all diabetic complications.

  15. Effects of the substitution of iron for cobalt on the crystal and magnetic properties of PrCo4-xFexM (M=Al and Ga)

    International Nuclear Information System (INIS)

    Zlotea, C.; Isnard, O.

    2003-01-01

    We report on the structural and magnetic properties of PrCo 4-x Fe x M where x=0-4 and M=Al and Ga. The iron solubility limit in these phases is determined by means of X-ray diffraction and scanning electron microscopy. Our study confirms that single phase samples crystallizing in the CaCu 5 -type structure are stabilized for x 5 structure but with a slight preference for the 3g site. The saturation magnetization and the Curie temperature increase upon the iron substitution. The PrCo 4-x Fe x M compounds present spin reorientation transitions, whatever the substituting M and the Fe content. The substitution of iron for cobalt induces a significant increase of the spin reorientation temperature. Neutron and X-ray powder diffraction experiments as well as magnetic measurements are combined in order to clarify the effects of the presence of iron on the magnetocrystalline anisotropy and the spin reorientation transition. Finally, the magnetic phase diagrams of PrCo 4-x Fe x M (M=Al and Ga) have been determined in the whole ordered temperature range

  16. Reconciliación de Malí; mayo en Kidal, inflexión en la segunda fase del proceso

    Directory of Open Access Journals (Sweden)

    Juan Carlos Castilla

    2015-01-01

    Full Text Available La reconciliación es uno de los retos de la consolidación de la paz. El ejercicio de la soberanía por parte de las instituciones locales, puede originar diferencias con las organizaciones internacionales durante la transformación del conflicto. El desafío es coordinar estrategias y medidas en el tiempo. El proceso de reconciliación comenzó en Malí con un gobierno de transición. Durante el año 2014, el gobierno ha tratado de impulsar el proceso, en un contexto en el que se han reproducido los enfrentamientos tribales, se han dado nuevos choques entre el MNLA y las Fuerzas Armadas malíes, y dónde sigue influyendo la actividad terrorista yihadista. IBK se refirió a aspectos fundamentales para el futuro inmediato del proceso tras los acontecimientos de mayo en Kidal. Tras estos acontecimientos, las negociaciones de paz se desarrollan con la mediación argelina. La complementariedad entre la justicia nacional y la internacional será una de las claves, lo que a su vez puede interrelacionar con la potencial re-integración futura de excombatientes.

  17. Efeitos ambientais da produção de suínos ao ar livre: evolução e distribuição espacial das formas de P no solo e perdas de P na água de drenagem Environmental impact of outdoor pig production: soil P forms evolution spatial distribution and P losses in drainage waters

    Directory of Open Access Journals (Sweden)

    Carmo Horta

    2012-06-01

    Full Text Available A produção de suínos ao ar livre é considerada pelos consumidores como um modo de produção mais amigo do ambiente e do bem-estar animal. No entanto, os nutrientes contidos na ração e no "excreta" dos suínos são continuamente introduzidos no solo conduzindo a aumentos significativos desses nutrientes no solo, em especial do fósforo (P. Esta continua adição de P ao solo pode exceder a sua capacidade de retenção originando perdas significativas de P para as águas de drenagem e de escoamento superficial, contribuindo para a poluição difusa das águas superficiais. O principal objectivo deste trabalho foi avaliar o impacto da produção de suínos ao ar livre sobre o teor em P do solo avaliando a sua distribuição espacial e temporal, e avaliar também a perda de P através das águas de drenagem interna do solo. A unidade experimental de produção de suínos ao ar livre deste trabalho tem 2.8 ha, um declive entre 5 e 30% e uma carga animal de 9 adultos / ha. Observou-se um aumento do P do solo, quer do P biodisponível (P Olsen, P-Ol quer do P inorgânico (Pi ou orgânico (Po. No Inverno observaram-se elevadas perdas de P por erosão e escoamento superficial, mas ao longo do tempo observou-se um aumento global do P no solo. Um teor em P-Ol > 20 mg kg-1 originou um aumento significativo na perda de P para as águas de drenagem interna. Melhores práticas de maneio da unidade experimental, bem como uma escolha da área de produção menos susceptível à erosão, conduzirão a uma prevenção nos riscos de perda de P e na eutrofização das águas superficiais.When compared with intensive indoor production, outdoor pig production is considered by consumers as the production system that causes the least negative environmental effects and contributes to animal welfare. Nevertheless, the continuous input of nutrients in food or pig excretions, increases soil nutrients levels, as is the case with phosphorus (P. This continuous soil P

  18. Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em recém-nascidos de grávidas com malária, na Colômbia

    Directory of Open Access Journals (Sweden)

    Alberto Tobón-Castaño

    2011-06-01

    Full Text Available INTRODUÇÃO: É frequente a associação da malária com complicações como prematuridade, retardo no crescimento intrauterino, baixo peso ao nascer e mortalidade infantil, efeitos pouco estudados em áreas hipoendêmicas para malaria. O objetivo deste estudo foi analisar a relação da malária gestacional com estes efeitos em recém-nascidosnuma região endêmica para malária na Colômbia, entre 1993 e 2007. MÉTODOS: Foram estudadas as características em 1.716 recém-nascidos num estudo de coorte. Fez-se seguimento em 394 gestantes com malária (27% por Plasmodium falciparum e 73% por P. vivax e 1.322 sem malária. RESULTADOS: Foi encontrada uma relação entre a exposição à malária na gestação e o risco maior de baixo peso ao nascer (RR = 1,37; 1,03-1,83, assim como estatura baixa (RR = 1,52; 1,25-1,85, retardo no crescimento intrauterino (RR = 1,29; 1,0-1,66 e prematuridade (RR = 1,68; 1,3-2,17. A frequência de nascimentos prematuros foi maior nas mães com malária por P. falciparum (77% que aquelas com P. vivax (RR = 1,77; IC 95%: 1,2-2,6. CONCLUSÕES: O baixo peso ao nascer e o retardo no crescimento foi associado com malária na gestação na Colômbia. A infecção por P. vivax foi relacionada com efeitos adversos sobre o recém-nascido, de modo semelhante em relação ao P. falciparum.

  19. Rugas e pneuzinhos, que mal tem? O discurso da beleza fora dos padrões na publicidade

    Directory of Open Access Journals (Sweden)

    Nadezhda Bezerra Batista

    2010-12-01

    Full Text Available O presente artigo tem o intuito de mostrar, através da apresentação de anúncios dasempresas de cosméticos Natura e Dove que  o discurso publicitário reflete e refrata a sociedade em que esta inserido para se tornar ainda mais sedutor e mais afinado com seu público-alvo. A partir de seus anúncios  veiculados nas décadas de 90 (Natura e 2000 (Dove, cada empresa, a seu tempo, se mostra em sintonia com os anseios de suas consumidoras, abrindo caminho para uma valorização e fidelização às suas marcas. Para atingirmos nosso objetivo nos fundamentaremos nas reflexões de Mikhail Bakhtin e Norman Fairclough. 

  20. O melhor interesse da criança e o "mal menor": quando os requerentes são gays

    OpenAIRE

    Uziel, Anna Paula

    2012-01-01

    A partir da Constituição Federal de 1988, a legislação brasileira considera família como composta por qualquer dos pais e seus filhos, sem distinção se são biológicos ou adotivos, e sem necessidade do casamento como base. A lei não se refere à orientação sexual. A homossexualidade dos pais, que pode aparecer nos relatórios de assistentes sociais ou psicólogos, não tem impedido a adoção. E desde 2005 é possível um casal de pessoas do mesmo sexo adotar uma criança, que tem seu registro civil no...

  1. Malé osobnosti veľkých dejín – veľké osobnosti malých dejín IV. Príspevky k hudobnej regionalistike, Slovenské národné múzeum – Hudobné múzeum, Brämerova kúria, Bratislava 30. listopadu – 1. prosince 2017

    Czech Academy of Sciences Publication Activity Database

    Kachlík, Jan

    2018-01-01

    Roč. 55, č. 1 (2018), s. 102-104 ISSN 0018-7003. [Malé osobnosti veľkých dejín – veľké osobnosti malých dejín IV. Príspevky k hudobnej regionalistike. Bratislava, 30.11.2017-01.12.2017] Institutional support: RVO:68378076 Keywords : music ology * conference Subject RIV: AL - Art, Architecture, Cultural Heritage OBOR OECD: Performing arts studies ( Music ology, Theater science, Dramaturgy)

  2. Melanoma NOS1 expression promotes dysfunctional IFN signaling.

    Science.gov (United States)

    Liu, Qiuzhen; Tomei, Sara; Ascierto, Maria Libera; De Giorgi, Valeria; Bedognetti, Davide; Dai, Cuilian; Uccellini, Lorenzo; Spivey, Tara; Pos, Zoltan; Thomas, Jaime; Reinboth, Jennifer; Murtas, Daniela; Zhang, Qianbing; Chouchane, Lotfi; Weiss, Geoffrey R; Slingluff, Craig L; Lee, Peter P; Rosenberg, Steven A; Alter, Harvey; Yao, Kaitai; Wang, Ena; Marincola, Francesco M

    2014-05-01

    In multiple forms of cancer, constitutive activation of type I IFN signaling is a critical consequence of immune surveillance against cancer; however, PBMCs isolated from cancer patients exhibit depressed STAT1 phosphorylation in response to IFN-α, suggesting IFN signaling dysfunction. Here, we demonstrated in a coculture system that melanoma cells differentially impairs the IFN-α response in PBMCs and that the inhibitory potential of a particular melanoma cell correlates with NOS1 expression. Comparison of gene transcription and array comparative genomic hybridization (aCGH) between melanoma cells from different patients indicated that suppression of IFN-α signaling correlates with an amplification of the NOS1 locus within segment 12q22-24. Evaluation of NOS1 levels in melanomas and IFN responsiveness of purified PBMCs from patients indicated a negative correlation between NOS1 expression in melanomas and the responsiveness of PBMCs to IFN-α. Furthermore, in an explorative study, NOS1 expression in melanoma metastases was negatively associated with patient response to adoptive T cell therapy. This study provides a link between cancer cell phenotype and IFN signal dysfunction in circulating immune cells.

  3. Malaria infection and the anthropological evolution Infecção por Malária e evolução antropológica

    Directory of Open Access Journals (Sweden)

    Sergio Sabbatani

    2010-03-01

    malária exerceu papel biológico chave, influenciando até o desenvolvimento antropológico. Os Plasmódios causadores da malária desenvolveram dois tipos de evolução, segundo um ponto de vista biológico, e filogenético. Em particular, os Plasmódios vivax, malariae, e ovale poderiam ter coevoluído com a espécie humana ou ter atingido esta durante as fases mais antigas da evolução do gênero HOMO. Por outro lado, o Plasmódio falciparum teria sido transmitido aos humanos por macacos num período mais recente, provavelmente entre o fim da Idade Mesolítica e o início da Neolítica. Os Autores mostram evidências biomoleculares, tanto diretas como indiretas, de infecção por malária, observada em indivíduos enterrados, reportando ao Mundo Antigo, e trazidas à luz no decorrer de escavações arqueológicas em alguns sítios relevantes Mediterrâneos. Nesta revisão da literatura, os autores organizam evidências modernas. Confirmam o papel da malária ao afetar a evolução das populações no Mediterrâneo. As pessoas que moram nas várias regiões do Mediterrâneo foram progressivamente influenciadas pela malária, ao longo do avanço desta doença. Além disso, as populações afetadas desenvolveram adaptações culturais, alimentares, e de comportamento, contribuindo para uma redução no risco da doença. Entretanto, pode ser que ambas modificações (as biológicas e as dos hábitos usadas pelos Plasmódios da malária, favoreceram a emergência de grupos de pessoas com maior resistência contra a malária. Todos estes fatores considerados reduziram o impacto demográfico, influenciando de uma maneira favorável o desenvolvimento em geral, e o crescimento da civilização.

  4. Expression analysis of NOS family and HSP genes during thermal stress in goat ( Capra hircus)

    Science.gov (United States)

    Yadav, Vijay Pratap; Dangi, Satyaveer Singh; Chouhan, Vikrant Singh; Gupta, Mahesh; Dangi, Saroj K.; Singh, Gyanendra; Maurya, Vijay Prakash; Kumar, Puneet; Sarkar, Mihir

    2016-03-01

    Approximately 50 genes other than heat shock protein (HSP) expression changes during thermal stress. These genes like nitric oxide synthase (NOS) need proper attention and investigation to find out their possible role in the adaptation to thermal stress in animals. So, the present study was undertaken to demonstrate the expressions of inducible form type II NOS (iNOS), endothelial type III NOS (eNOS), constitutively expressed enzyme NOS (cNOS), HSP70, and HSP90 in peripheral blood mononuclear cells (PBMCs) during different seasons in Barbari goats. Real-time polymerase chain reaction, western blot, and immunocytochemistry were applied to investigate messenger RNA (mRNA) expression, protein expression, and immunolocalization of examined factors. The mRNA and protein expressions of iNOS, eNOS, cNOS, HSP70, and HSP90 were significantly higher ( P goats.

  5. Nanotecnologia farmacêutica aplicada ao tratamento da malária Application of pharmaceutical nanotechnology to the treatment of malaria

    Directory of Open Access Journals (Sweden)

    Lúcio Figueira Pimentel

    2007-12-01

    Full Text Available Apesar do desenvolvimento tecnológico e científico, a malária permanece como um dos maiores problemas de saúde a serem combatidos. As estratégias modernas para o controle da doença prevêem ações conjuntas, como o combate do inseto vetor, diagnóstico rápido e preciso, garantia de terapêutica adequada, redução dos casos de resistência, além do desenvolvimento de novos agentes terapêuticos e vacina e através da otimização da ação de fármacos utilizados na atualidade. Os sistemas de liberação controlada de fármacos vêm recebendo atenção especial nesta área de pesquisa, com o desenvolvimento de estratégias para a veiculação de agentes bioativos e vacinas na forma de nanodispositivos tais como lipossomas, nanopartículas e micropartículas. Diversos nanossistemas já demonstraram eficácia na otimização de vacinas e quimioterápicos destinados ao controle da malária. Este artigo de revisão tem por objetivo avaliar o estado da arte na terapêutica da malária e demonstrar o potencial da nanotecnologia farmacêutica como ferramenta destinada ao combate da doença.In spite of living in a scientific and technological era, malaria continues to be one of the worldwide greatest health challenges. The state-of-the-art policy to keep malaria under control is expected to comprise joint-strategies, such as the vector control, fast diagnosis, therapeutic guarantee, resistance cutback, drug optimization and development of new therapeutic agents and vaccines. Nano and microcarrier systems have been receiving a special attention, including the development of strategies for carrying bioactive agents, vaccines through nanodevices, such as liposomes and nanoparticles, and microdevices, such as microparticles and microemulsions. Numerous nanosystems have already substantiated their effectiveness to optimize vaccines, insecticides, and chemotherapeutic agents applied to the control of malaria. This review is intended to explain the

  6. DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer

    International Nuclear Information System (INIS)

    Kalmár, Alexandra; Péterfia, Bálint; Hollósi, Péter; Galamb, Orsolya; Spisák, Sándor; Wichmann, Barnabás; Bodor, András; Tóth, Kinga; Patai, Árpád V.; Valcz, Gábor; Nagy, Zsófia Brigitta; Kubák, Vivien; Tulassay, Zsolt; Kovalszky, Ilona; Molnár, Béla

    2015-01-01

    Colorectal cancer (CRC) development is accompanied by changes in expression for several genes; but the details of the underlying regulatory procesess remain unknown. Our aims were to assess the role of epigenetic processes in tumour formation and to identify characteristic DNA methylation and miRNA alterations in the colorectal adenoma-carcinoma sequence. Whole genome expression profiling was performed on colonic biopsy samples (49 healthy normal, 49 colorectal adenoma (AD), 49 CRC); on laser capture microdissected (LCM) epithelial and stromal cells from 6 CRC-normal adjacent tissue (NAT) samples pairs, and on demethylated human CRC cell lines using HGU133 Plus 2.0 microarrays (Affymetrix). Methylation status of genes with gradually altering expression along the AD-CRC sequence was further analysed on 10–10 macrodissected and 5–5 LCM samples from healthy colon, from adenoma and from CRC biopsy samples using bisulfite-sequencing PCR (BS-PCR) followed by pyrosequencing. In silico miRNA prediction for the selected genes was performed with miRWALK algorithm, miRNA expression was analysed on 3 CRC-NAT sample pairs and 3 adenoma tissue samples using the Human Panel I + II (Exiqon). SFRP1 immunohistochemistry experiments were performed. A set of transcripts (18 genes including MAL, SFRP1, SULT1A1, PRIMA1, PTGDR) showed decreasing expression (p < 0.01) in the biopsy samples along the adenoma-carcinoma sequence. Three of those (COL1A2, SFRP2, SOCS3) showed hypermethylation and THBS2 showed hypomethylation both in AD and in CRC samples compared to NAT, while BCL2, PRIMA1 and PTGDR showed hypermethylation only in the CRC group. miR-21 was found to be significantly (p < 0.01) upregulated in adenoma and tumour samples compared to the healthy colonic tissue controls and could explain the altered expression of genes for which DNA methylation changes do not appear to play role (e.g. BCL2, MAL, PTGS2). Demethylation treatment could upregulate gene expression of genes that were

  7. A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.

    NARCIS (Netherlands)

    Nagpal, K.; Plantinga, T.S.; Wong, J.; Monks, B.G.; Gay, N.J.; Netea, M.G.; Fitzgerald, K.A.; Golenbock, D.

    2009-01-01

    The adapter protein MyD88 adapter-like (Mal), encoded by TIR-domain containing adapter protein (Tirap) (MIM 606252), is the most polymorphic of the five adapter proteins involved in Toll-like receptor signaling, harboring eight non-synonymous single nucleotide polymorphisms in its coding region. We

  8. Debata o památkové péči v 60. letech 20. století. Ivo Loos, Jindřich Malátek a Transgas

    Czech Academy of Sciences Publication Activity Database

    Švácha, Rostislav

    2017-01-01

    Roč. 77, č. 4 (2017), s. 361-372 ISSN 1210-5538 Institutional support: RVO:68378033 Keywords : Jindřich Malátek * Ivo Loos * postwar architecture * theory of architecture and heritage care * Transgas Subject RIV: AL - Art, Architecture, Cultural Heritage

  9. Envolvimento nos direitos humanos e sistemas de valores

    OpenAIRE

    Pereira,Cícero; Ribeiro,Ana Raquel Correia; Cardoso,Sandro José

    2004-01-01

    Com base no modelo da análise quantitativa das representações sociais, o estudo (N = 300) tratou do posicionamento de estudantes universitários em relação aos Direitos Humanos (DHs) e à ancoragem social desse posicionamento nos sistemas de valores dos estudantes. Os resultados mostram que as representações dos estudantes sobre o envolvimento nos DHs envolvem quatro princípios organizadores: pessoal-abstrato; pessoal-concreto; governamental-abstrato; governamental-concreto. Em relação à ancora...

  10. Realezas entre o bem e o mal: as representações de monarcas nas páginas da Marvel Comics

    OpenAIRE

    Guerra, Fábio Vieira

    2016-01-01

    Este trabalho propõe analisar três das monarquias apresentadas nas narrativas da editora americana de quadrinhos Marvel Comics. Essas histórias têm como protagonistas seres com habilidades extraordinárias chamados de super-heróis. Pautados em uma disputa dualista entre o Bem e o Mal, os quadrinhos de super-heróis são expressão de um imaginário coletivo sobre a nação estadunidense e os valores que norteiam sua organização social e suas ações no mundo. Desse modo, a representação de outros país...

  11. Pensamentos, sentimentos, vontades e afetos: a fisio-psicologia de Nietzsche a partir do aforismo 19 de Para Além de Bem e Mal

    Directory of Open Access Journals (Sweden)

    Bruno Martins Machado

    2011-05-01

    Full Text Available O presente estudo busca apresentar como a noçáo de fisio-psicologia proposta por Nietzsche se estrutura sobre o corpo e exige uma alteraçáo particular na determinaçáo da noçáo de vontade. Para realizar tal empreendimento, tomamos como parâmetro principalmente o aforismo 19 de Para Além de Bem e Mal. Neste texto, Nietzsche apresenta uma releitura da noçáo de vontade a partir da análise da estrutura dos afetos, dos pensamentos e dos sentimentos. A importância desse empreendimento se justifica por abrir espaço para uma proposta psicológica baseada em um dinamismo que está para além dos processos conscientes.

  12. Založení malého podniku, jeho podnikatelský záměr

    OpenAIRE

    Vávrová, Lenka

    2010-01-01

    Tato diplomová práce se zabývá vypracováním podnikatelského záměru na založení restaurace. Teoretická část práce popisuje předpoklady pro dobře vypracovaný podnikatelský plán. V praktické části je provedena SWOT analýza, analýza vnějšího okolí a finanční zajištění podnikatelské činnosti. Na závěr je navržen plán strategie rozvoje podniku a zhodnocení jeho přínosů. This thesis focuses on developing a business plan to establish a restaurant. The theoretical part describes the prerequisites f...

  13. Reposição cirúrgico-ortopédica de implante mal posicionado: relato de caso Surgical-orthopedic repositioning of malpositioned implant: a case report

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Ferreira da Silva

    2005-06-01

    Full Text Available A reabilitação bucal por meio da colocação de implantes dentários tem se tornado um procedimento freqüente da clínica odontológica. Falhas no planejamento ou na execução da técnica podem levar a casos onde, apesar de osseointegrado, o implante não apresenta condições de restauração satisfatória devido ao seu mal posicionamento. Diversos autores têm relatado a possibilidade de se utilizar osteotomias segmentares de maxila ou mandíbula para reposicionar um segmento alveolar com implante, mostrando que esta pode ser uma técnica efetiva e previsível para restaurar implantes em posição anatômica comprometida. O presente trabalho apresenta o caso clínico de uma paciente de 20 anos de idade onde foi realizada osteotomia segmentar de maxila associada à distração osteogênica para correção de um implante mal posicionado.Oral rehabilitation through dental implants has become a common procedure at dental practice. However, if the implant is placed in an inappropriate position either because of inadequate presurgical planning or poor surgical technique, it may be unrestorable in spite of osseointegrated. Many authors have reported the possibility of using segmental maxillary or mandibular osteotomies to reposition an alveolar segment with its implants. This can be an effective, predictable technique for restoring implants in a compromised anatomic position. This paper presents a case report describing the use of this procedure associated to distraction osteogeneis to reposition one malpositioned implant in a 20 years old girl.

  14. Los medios de comunicación ¿nos igualan o nos diferencian?

    Directory of Open Access Journals (Sweden)

    Javier BALLESTA PAGÁN

    2009-05-01

    Full Text Available RESUMEN: En este artículo presentamos los resultados obtenidos en una investigación llevada a cabo en los centros educativos de Educación Secundaria Obligatoria de la Región de Murcia donde se ha pretendido valorar el equipamiento, el acceso a la información y el consumo de medios de comunicación en el hogar, por parte del alumnado inmigrante en comparación con el autóctono. Los datos aportados de dicho estudio nos confirman que la mayoría de los recursos más utilizados en el hogar es menor en los hogares del alumnado inmigrante de Educación Secundaria Obligatoria (ESO respecto al resto de la muestra en general de los alumnos. Por otra parte, el acceso a los medios, para estos alumnos inmigrantes, corrobora que son considerados recursos de gran importancia como vehículos en su acercamiento al aprendizaje y al entretenimiento. En cuanto al uso personal de dichos medios de comunicación observamos que mientras el ordenador, el móvil y el DVD son muy utilizados, comprobamos cómo desciende su uso e interés cuando abordamos otros medios de papel impreso, entre los que destacamos el libro y el periódico. Sin embargo, el uso de la televisión es bastante similar en ambos colectivos. Con relación al acceso a Internet, los resultados analizados parecen confirmar que el hogar se convierte en el lugar adecuado para su uso en ambas muestras, por encima de otros espacios públicos o privados. Sin embargo, si comprobamos la disponibilidad de acceso al mismo en el hogar por parte del alumnado inmigrante, destacamos que es menor de la que disponen los hogares autóctonos. En relación con la lectura, el nivel lector de estos jóvenes inmigrantes es también menor, aunque no existe una gran diferencia, respecto de la muestra de alumnos autóctonos. Al valorar el uso que hacen de la biblioteca comprobamos que más de la mitad de los alumnos afirman ir a ella, pero preferentemente a la pública más que la biblioteca del centro o a la de otras

  15. The Merit Selection Processes in the Senior Management of the Portuguese Public Administration: Myth or Reality?/O Mérito nos Processos de Seleção da Alta Direção da Administração Pública Portuguesa: mito ou realidade?

    Directory of Open Access Journals (Sweden)

    João Bilhim

    2012-12-01

    Full Text Available The influence on managerial model of administrative reform in Portugal and in particular with regard to the introduction of higher technical rationality in the processes of public management is widely recognized in Portugal. There were many governments in OECD countries have taken similar initiatives. However, the literature on administrative reform presents enough evidence of the resilience of institutional bureaucracies to change. It turns out that the NPM would assert itself as a standard recipe without respect for cultural diversity and the various administrations, despite taking over as primer, got different expressions and manifestations. This article aims to contribute to this debate. Therefore, examines the influence of meritocracy, as NPM idea, administrative reform of PortugaA influência do modelo gestionário na reforma administrativa em Portugal e, em particular, no que se refere à introdução de maior racionalidade técnica nos processos de gestão pública é amplamente reconhecida em Portugal. Foram muitos os governos que, nos países da OCDE, tomaram iniciativas idênticas. Todavia, a literatura sobre a reforma administrativa apresenta bastante evidência da resili-ência das burocracias institucionais à mudança. Acontece que a NPM quis afirmar-se como uma receita padrão sem respeito pela diversidade cultural das diversas administrações e, apesar de se assumir como cartilha, obteve diferentes expressões e manifestações. Este artigo quer contribuir para este debate. Por isso, examina a influência da meritocracia, como ideia do NPM, na reforma administrativa de Portugal.

  16. Las Rocas Nos Cuentan (Rocks Tell Their Stories)

    Science.gov (United States)

    Llerandi-Roman, Pablo A.

    2012-01-01

    Many Earth science lessons today still focus on memorizing the names of rocks and minerals. This led the author to develop a lesson that reveals the fascinating stories told by rocks through the study of their physical properties. He first designed the lesson for Puerto Rican teachers, hence its Spanish title: "Las Rocas Nos Cuentan Su Historia."…

  17. Pubertal development of penile Nitric Oxide Synthase (NOS ...

    African Journals Online (AJOL)

    Conclusion: The number of NADPH-positive fibers increases with age; however similar tumescence was recorded following electrostimulation in all age groups. NOS-nerve growth correlates with serum testosterone level. The increase of NADPH-positive fibers was accompanied by a decrease in the delay of onset of penile ...

  18. The influence of authentic scientific research experiences on teachers' conceptions of the nature of science (NOS) and their NOS teaching practices

    Science.gov (United States)

    Moriarty, Meghan A.

    This study explored the influence of teachers' authentic scientific research experiences (ASREs) on teachers' conceptions of the nature of science (NOS) and teachers' NOS instruction. Twelve high school biology teachers participated in this study. Six of the participants had authentic scientific research experience (ASRE) and six had not participated in authentic scientific research. Data included background surveys, modified Views of the Nature of Science (VNOS) questionnaires, interviews, and teaching observations. Data was coded based on the eight NOS understandings outlined in 2013 in the Next Generation Science Standards (NGSS). Evidence from this study indicates participating in authentic scientific research as a member of a scientific community has dual benefits of enabling high school science teachers with informed understandings of the NOS and positioning them to teach with the NOS. However, these benefits do not always result from an ASRE. If the nature of the ASRE is limited, then it may limit teachers' NOS understandings and their NOS teaching practices. The results of this study suggest that participation in ASREs may be one way to improve teachers' NOS understandings and teaching practices if the experiences themselves offer a comprehensive view of the NOS. Because ASREs and other science learning experiences do not always offer such experiences, pre-service teacher education and professional development opportunities may engage science teachers in two ways: (1) becoming part of a scientific community may enable them to teach with NOS and (2) being reflective about what being a scientist means may improve teachers' NOS understandings and better position them to teach about NOS.. Keywords: nature of science, authentic scientific research experiences, Next Generation Science Standards, teaching about NOS, teaching with NOS.

  19. Posição viciosa de cabeça por astigmatismo mal corrigido: relato de caso Abnormal head position caused by incorrect prescription for astigmatism: case report

    Directory of Open Access Journals (Sweden)

    Flávia Augusta Attié de Castro

    2005-10-01

    Full Text Available A posição viciosa de cabeça é uma condição compensatória que visa proporcionar aos pacientes melhor rendimento visual. Pode ser causada por problemas oftalmológicos, como distúrbios oculomotores (nistagmos, estrabismos e altos astigmatismos. No entanto, compromete a estética e, a longo prazo, pode causar transtornos ortopédicos (coluna cervical e assimetrias faciais. Relatamos o caso de uma garota, JL, 8 anos, com cabeça inclinada para esquerda havia vários anos. Fazia uso de óculos prescritos em outro serviço para correção de astigmatismo misto: OD= +2,00 DE Ç -5,50 DC a 180º e OE= +2,25 DE Ç -5,75 DC a 180º. No exame oftálmico, a paciente apresentava cabeça inclinada para a esquerda e acuidade visual com correção de 0,5 no OD e 0,7 OE. Os testes de cobertura simples e alternado não evidenciaram desvio ocular. Rotações oculares, biomicroscopia e fundoscopia também não mostraram alterações. Na refratometria sob cicloplegia e teste de lentes foram encontrados: OD= +3,50 DE Ç -6,00 DC a 10º e OE= +3,50 DE Ç -6,00 DC a 170º, com acuidade visual igual a 1,0 nos olhos direito e esquerdo. Foram prescritas as lentes encontradas no exame e a paciente retornou com a correção nova sem a inclinação de cabeça. Erros refracionais mal corrigidos também podem gerar torcicolo e, muitas vezes, passam despercebidos. Refratometria sob cicloplegia e teste de lentes são fundamentais para um diagnóstico preciso.Abnormal head position is a compensatory condition which improves patients' vision. It can be caused by ophthalmological problems such as oculomotor imbalances (strabismus, nystagmus and high astigmatisms. However, it results in esthetic impairment, orthopedic trouble and facial asymmetries. We describe a case of a girl, JL, 8 years, with abnormal head position tilted to the left since the last glasses were prescribed. The correction used by the patient was: right eye = +2.00 sph à -5.5 cyl 180° and left eye = +2

  20. Melhoramento do milho: II - Germoplasma utilizado nos trabalhos de seleção

    Directory of Open Access Journals (Sweden)

    G. P. Viegas

    1952-09-01

    linhagens muito promissoras derivadas do mesmo milho. Cumpre ressaltar ainda que, em Viçosa, do milho Tuxpan, foi isolada a L. 94-956, cujo comportamento é muito satisfatório. De par com as variedades, foram introduzidas também linhagens puras. Em 1941 e 1942, houve oportunidade de conseguir amostras de 153 linhagens nos Estados Unidos, obtidas nos principais centros de melhoramento do cereal em Wisconsin, Iowa, Mississippi, Illinois, Connecticut e North Carolina. De todo êsse material, apenas as conhecidas linhagens norte-americanas 38-11 e Hy portaram-se de modo relativamente satisfatório, nas nossas condições. O milho de procedência norte-americana é, em geral, muito precoce e tem pouca palha, o que o torna muito sujeito ao ataque do caruncho e da traça. De outras procedências, como da Argentina, por exemplo, também foram obtidas algumas linhagens. Com exceção das recebidas de outros centros do próprio país, devotados ao melhoramento do milho, - notadamente Viçosa, Piracicaba e Ipanema - as demais linhagens recebidas não se portaram bem nas nossas condições. Foram introduzidas ainda amostras de sementes de híbridos. Queremos nos referir especialmente às remessas feitas dos Estados Unidos, diretamente, ou por intermédio de firmas locais, interessadas. Êstes híbridos portaram-se, todos êles, muito mal. Atualmente, está sendo observado o comportamento dos híbridos simples sintetizados no México e na Colômbia, cruzados com híbridos obtidos no Brasil.In order to diversify the maize germplasm utilized in the breeding work conducted at the Instituto Agronômico, at Campinas, São Paulo, Brazil, efforts were made to obtain corn samples from the most diversified origins. Seeds of numerous varieties, inbred lines and hybrids were introduced and their performance observed under local conditions. Until 1951, a total of 1405 samples were introduced, most of them being derived from various parts of Brazil. From the United States, Colombia, Peru, Bolivia

  1. Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS

    Directory of Open Access Journals (Sweden)

    Mohamed A. Morsy

    2014-01-01

    Full Text Available Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious Gram-negative infections. However, its usefulness is limited by its nephrotoxicity. Sildenafil, a selective phosphodiesterase-5 inhibitor, was reported to prevent or decrease tissue injury. The aim of this study is to evaluate the potential protective effects of sildenafil on gentamicin-induced nephrotoxicity in rats. Male Wistar rats were injected with gentamicin (100 mg/kg/day, i.p. for 6 days with and without sildenafil. Sildenafil administration resulted in nephroprotective effect in gentamicin-intoxicated rats as it significantly decreased serum creatinine and urea, urinary albumin, and renal malondialdehyde and nitrite/nitrate levels, with a concomitant increase in renal catalase and superoxide dismutase activities compared to gentamicin-treated rats. Moreover, immunohistochemical examination revealed that sildenafil treatment markedly reduced inducible nitric oxide synthase (iNOS expression, while expression of endothelial nitric oxide synthase (eNOS was markedly enhanced. The protective effects of sildenafil were verified histopathologically. In conclusion, sildenafil protects rats against gentamicin-induced nephrotoxicity possibly, in part, through its antioxidant activity, inhibition of iNOS expression, and induction of eNOS production.

  2. Avaliação dos níveis das transaminases dos pacientes com infecção pelo Plasmodium vivax atendidos em um centro de referência para tratamento da malária no Estado de Mato Grosso

    Directory of Open Access Journals (Sweden)

    Elisane de Freitas Pereira

    2017-11-01

    Full Text Available Objetivo: Analisar os marcadores hepáticos (transaminases em pacientes com malária causada pelo Plasmodium vivax. Métodos: Trata-se de um estudo transversal retrospectivo, incluindo pacientes que apresentaram monoinfecção pelo P. vivax. O teste de Mann-Whitney U ou o teste t de Student foram utilizados para comparar a atividade média das transaminases de acordo com a classificação clínica e epidemiológica do paciente infectado. O teste de Kruskal-Wallis foi utilizado para comparar a média da atividade das transaminases de acordo com a classificação da infecção. Valores de p<0,05 foram considerados significativos. Resultados: Indivíduos menores de 7 anos apresentaram maior atividade da transaminase glutâmico oxalacética (TGO e da transaminase glutâmico pirúvica (TGP — respectivamente, 68,7 U/L e 79,8 U/L — em relação a pacientes com idade de 8 a 59 anos (TGO 29,8 U/L e TGP 39,2 U/L e acima de 60 anos (TGO 32,5 U/L e TGP 34 U/L. A média da dosagem sérica de TGO de todos os pacientes incluídos no estudo foi de 31,99 U/L e de TGP foi de 41,1 U/L. A atividade de TGP nos pacientes primoinfectados foi maior que nos reinfectados ou com recaída, sendo 65,6 U/L contra 36,2 U/L e 32,7 U/L, respectivamente. Conclusão: Crianças apresentam maior atividade de transaminases que os indivíduos maiores de sete anos de idade. Pacientes com infecção prévia pelo P. vivax apresentam menores valores séricos da atividade das transaminases do que os primoinfectados. Indivíduos com episódios de recaída apresentam menores valores das enzimas avaliadas do que aqueles com reinfecção ou primoinfecção.

  3. Occurrence of anti-Toxoplasma gondii antibodies in cattle and pigs slaughtered, State of Rio de Janeiro Ocorrência de anticorpos anti-Toxoplasma gondii em bovinos e suínos abatidos, Estado do Rio de Janeiro

    Directory of Open Access Journals (Sweden)

    Daniela Martins Luciano

    2011-12-01

    Full Text Available This study aimed to estimate the occurrence of anti-Toxoplasma gondii antibodies by means of the Indirect Immunufluorescent Antibody Assay (IFAT in cattle and pigs from slaughterhouses in two municipalities in the State of Rio de Janeiro. IgG anti-T. gondii antibodies was found in 1.96% (9/459 of the cattle and 7.64% (31/406 of the pigs, without any positive association (p > 0.05 with risk factors for transmission and seropositivity. Taking the cutoff point of IFAT ³ 1:64, titers of 64 and 256 were detected, suggesting chronic infection. Despite the low prevalence rates found for cattle and pigs, these indicated environmental contamination in the municipalities investigated, biosafety failures at the technified pig farm evaluated and the possibility of human and animal infection through eating raw or undercooked meat from these animals.Este trabalho objetivou estimar a ocorrência de anticorpos anti-Toxoplasma gondii por meio da Reação de Imunofluorescência Indireta (RIFI em bovinos e suínos de abatedouros de dois municípios do Estado do Rio de Janeiro. Anticorpos IgG anti-T. gondii foram encontrados em 1,96% (9/459 dos bovinos e em 7,64% (31/406 dos suínos, sem associação positiva (p > 0,05 em relação aos fatores de risco de transmissão e a soropositividade. Considerando-se o ponto de corte (RIFI ³ 1:64, foram detectados os títulos de 64 e 256, sugestivos de infecção crônica. Apesar de baixas, as prevalências encontradas para bovinos e suínos indicaram contaminação ambiental nos municípios avaliados, falhas na biossegurança da granja tecnificada de suínos e a possibilidade de infecção humana e animal pela ingestão da carne crua ou mal passada desses animais.

  4. Effects of cyclooxygenase inhibitor pretreatment on nitric oxide production, nNOS and iNOS expression in rat cerebellum.

    Science.gov (United States)

    Di Girolamo, G; Farina, M; Riberio, M L; Ogando, D; Aisemberg, J; de los Santos, A R; Martí, M L; Franchi, A M

    2003-07-01

    1. The therapeutic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) is thought to be due mainly to its inhibition of cyclooxygenase (COX) enzymes, but there is a growing body of research that now demonstrates a variety of NSAIDs effects on cellular signal transduction pathways other than those involving prostaglandins. 2. Nitric oxide (NO) as a free radical and an agent that gives rise to highly toxic oxidants (peroxynitrile, nitric dioxide, nitron ion), becomes a cause of neuronal damage and death in some brain lesions such as Parkinson and Alzheimer disease, and Huntington's chorea. 3. In the present study, the in vivo effect of three NSAIDs (lysine clonixinate (LC), indomethacine (INDO) and meloxicam (MELO)) on NO production and nitric oxide synthase expression in rat cerebellar slices was analysed. Rats were treated with (a) saline, (b) lipopolysaccharide (LPS) (5 mg kg(-1), i.p.), (c) saline in combination with different doses of NSAIDs and (d) LPS in combination with different doses of NSAIDs and then killed 6 h after treatment. 4. NO synthesis, evaluated by Bred and Snyder technique, was increased by LPS. This augmentation was inhibited by coadministration of the three NSAIDs assayed. None of the NSAIDs tested was able to modify control NO synthesis. 5. Expression of iNOS and neural NOS (nNOS) was detected by Western blotting in control and LPS-treated rats. LC and INDO, but not MELO, were able to inhibit the expression of these enzymes. 6. Therefore, reduction of iNOS and nNOS levels in cerebellum may explain, in part, the anti-inflammatory effect of these NSAIDs and may also have importance in the prevention of NO-mediated neuronal injury.

  5. Contribution of the nos-pdt operon to virulence phenotypes in methicillin-sensitive Staphylococcus aureus.

    Directory of Open Access Journals (Sweden)

    April M Sapp

    Full Text Available Nitric oxide (NO is emerging as an important regulator of bacterial stress resistance, biofilm development, and virulence. One potential source of endogenous NO production in the pathogen Staphylococcus aureus is its NO-synthase (saNOS enzyme, encoded by the nos gene. Although a role for saNOS in oxidative stress resistance, antibiotic resistance, and virulence has been recently-described, insights into the regulation of nos expression and saNOS enzyme activity remain elusive. To this end, transcriptional analysis of the nos gene in S. aureus strain UAMS-1 was performed, which revealed that nos expression increases during low-oxygen growth and is growth-phase dependent. Furthermore, nos is co-transcribed with a downstream gene, designated pdt, which encodes a prephenate dehydratase (PDT enzyme involved in phenylalanine biosynthesis. Deletion of pdt significantly impaired the ability of UAMS-1 to grow in chemically-defined media lacking phenylalanine, confirming the function of this enzyme. Bioinformatics analysis revealed that the operon organization of nos-pdt appears to be unique to the staphylococci. As described for other S. aureus nos mutants, inactivation of nos in UAMS-1 conferred sensitivity to oxidative stress, while deletion of pdt did not affect this phenotype. The nos mutant also displayed reduced virulence in a murine sepsis infection model, and increased carotenoid pigmentation when cultured on agar plates, both previously-undescribed nos mutant phenotypes. Utilizing the fluorescent stain 4-Amino-5-Methylamino-2',7'-Difluorofluorescein (DAF-FM diacetate, decreased levels of intracellular NO/reactive nitrogen species (RNS were detected in the nos mutant on agar plates. These results reinforce the important role of saNOS in S. aureus physiology and virulence, and have identified an in vitro growth condition under which saNOS activity appears to be upregulated. However, the significance of the operon organization of nos-pdt and

  6. Participação nos Lucros ou Resultados

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    Luiz Felipe Ferreira

    2007-03-01

    Full Text Available A participação nos lucros ou resultados é uma forma de remuneração variável, pela qual não há incidência de encargos sociais, além de incentivar o aumento da produtividade, podendo assim ser utilizada pelas empresas como estratégia, para enfrentarem os desafios dinâmicos e competitivos em que atuam. Esta pesquisa caracteriza-se como sendo exploratória, com abordagem qualitativa e tem como objetivo conceituar e explanar as formas pela quais são praticadas a participação nos lucros ou resultados em empresas do setor alimentício em Santa Catarina, que foram escolhidas por meio do critério de acessibilidade e disponibilidade. Dos dados coletados, pode-se verificar que as empresas: COC Alimentos, Moinho Catarinense e Pepsico do Brasil utilizam a participação nos resultados e a Perdigão utiliza a participação mista. A Moinho Catarinense distribui para todos os empregados um salário nominal, como a CDC Alimentos, exceto para os gerentes. A Perdigão beneficia todos os empregados, sendo que 60% da distribuição é pelo lucro líquido e 40% por indicadores de desempenho. A Pepsico do Brasil distribui aos empregados operacionais 50% de um salário nominal e para os empregados da administração central um salário nominal, atrelado ao cumprimento de metas, especificadas no programa de participação nos lucros ou resultados.

  7. Tratamento de dejetos suínos com biorreator UASB

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    Pablo Costa da Silva

    2014-05-01

    Full Text Available Esse trabalho tem por objetivo analisar a importância do biodigestor UASB no tratamento de dejetos suínos. A suinocultura possui papel importante quanto ao desenvolvimento econômico do Brasil. No entanto, o aumento de produção vem causando problemas ambientais graves, por conta do grande volume de resíduos sólidos gerados pela atividade. O desenvolvimento de métodos de tratamento de dejetos que agreguem valor à produção e respeitem as leis ambientais é um dos grandes desafios do setor. A biodigestão anaeróbia é um dos métodos mais eficazes para o tratamento de dejetos de suinoculturas. Este método de digestão, denominado UASB, tem como característica principal a produção de biogás e de biofertilizante, produto rico em nutrientes, e livre de patógenos. O método oferece vantagens como a promoção do bem estar animal, o aumento da fertilidade do solo, a diminuição da poluição e da emissão de gases geradores do efeito estufa e a melhoria da qualidade de vida, nos centros produtores de suínos, além de minimizar problemas relacionados ao déficit de energia elétrica. Portanto, a utilização de biodigestores UASB para o tratamento de dejetos de suínos é uma opção interessante, que deve ser avaliada com seriedade.

  8. Pragmatismo e os pragmáticos nos estudos organizacionais

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    Francis Kanashiro Meneghetti

    Full Text Available O objetivo central deste ensaio teórico é avaliar as contribuições do pragmatismo nos Estudos Organizacionais e, os específicos, avaliar se as contribuições teóricas de Charles Peirce e John Dewey possibilitam afirmar o pragmatismo como senso comum, ciência ou teoria do conhecimento; analisar as contribuições - possibilidadese limites - do pragmatismo como conhecimento científico; compreender os percursos do pragmatismo nos Estudos Organizacionais. Chaga-se a conclusão de que ser pragmático é diferente de conceber estudos articulados no campo epistemológico do pragmatismo. O sujeito pragmático vê na sua utilidade e na necessidade deação, o ponto de tensão que coloca em dúvida a veracidade dos pressupostos do pragmatismo como ciência. O que ocorre nos Estudos Organizacionais éa conversão do pragmatismo como conhecimento científico emsubordinação irracional à utilidade e à ação prática, sobretudo, no campo da economia, da política, da ciência, da cultura, da educação, e assim por diante.

  9. Correction of vitamin D deficiency using sublingually administered vitamin D2 in a Crohn's disease patient with mal-absorption and a new ileostomy.

    Science.gov (United States)

    McCullough, Patrick; Heaney, Robert

    2017-10-01

    Vitamin D deficiency has been shown to be associated with many adverse health problems. Studies have shown that patients with Crohn's disease who have low vitamin D levels have a poorer quality of life than those with more adequate levels. It has also been shown that patients with mal-absorption problems have a difficult time achieving normal vitamin D levels in spite of aggressive supplementation, and that exposure to UVB radiation may be the most effective treatment option for these patients. We present a case in which 25-hydroxyvitamin D levels were normalized within 2 weeks in a severely vitamin D deficient patient with Crohn's disease with mal-absorption and a new ileostomy, utilizing sublingually administered vitamin D2. A 58 year-old white female was admitted with a new ileostomy following partial bowel resection due to complications from Crohn's disease. She was found to be severely vitamin D deficient at the time of admission, with a level of 6.1ng/ml on hospital day 3. Her treatment with vitamin D was delayed for a few days. She was initially treated with 5000 units of vitamin D3 orally twice a day for 3days (days 7-10). After discussion with the patient and obtaining her consent, vitamin D3 was stopped, and she was then treated with a total of 8 doses of 50,000 units of vitamin D2 administered sublingually. She was given the first 3 doses on alternating days (days 11, 13, 15), and then 5 more doses on consecutive days (days 17-21). The rise in her 25-hydroxyvitamin D level in response to treatment with sublingual vitamin D2 was significant. On day 10, after receiving 3days of orally administered vitamin D3, her level was 9.8ng/ml. One week later, after receiving 3 sublingual doses of vitamin D2, it rose to 20.3ng/ml. It was then measured on alternating days twice over the next 4days, and it rose to 45.5ng/ml, and then to 47.4ng/ml on the day of discharge to home. The major finding of this study is that sublingual administration of vitamin D2 appears to

  10. Mal de Pott en pediatría: presentación de 5 casos y revisión de la literatura

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    Gladys Abreu Suárez

    2002-09-01

    Full Text Available Se presentan 5 de los 6 niños afectados de mal de Pott en el período de 1995 a 2001, para una incidencia del 4,5 % del total de casos de tuberculosis infantil en Cuba. La mayoría de los niños tenía alrededor de 2 años de edad, con un predominio de la afectación lumbar en 4 pacientes. El cuadro clínico fue insidioso, y fueron más frecuentes el dolor de espalda y los trastornos a la marcha. El diagnóstico fue clinicorradiológico, y la tuberculina positiva en 4 niños. Sólo se aisló Micobacterium tuberculosis en un paciente, en el que concomitaban lesiones pulmonares. En 3 enfermos se hallaron abscesos paravertebrales (2 en la región dorsal, y el otro en el psoas. Aún se encuentran 3 pacientes en tratamiento; de los 2 curados, uno tiene pérdida de la lordosis fisiológica lumbar, y otro perdió un cuerpo vertebral con una giba residual ligera. Se concluye que, aunque la tuberculosis infantil no es un problema de salud en Cuba, y el mal de Pott no es frecuente, debe tenerse en cuenta ante un niño pequeño que se consulte con manifestaciones insidiosas de trastornos de la marcha y dolor de espalda.5 of the 6 children affected by Pott’s disease from 1995 to 2001 are presented in this paper for an incidence of 4.5 % of the total of cases of infantile tuberculosis in Cuba. Most of the children were about 2 years old. A predominance of lumbar affection was observed in 4 patients. The clinical picture was insidious and back pain and walking disorders were more frequent. The diagnosis was clinicoradiological and tuberculin was positive in 4 children. Micobacterium tuberculosis was only isolated from a patient with concomitant pulmonary injuries. Paravertebral abscesses (2 in the dorsal region and the other in the psoas were found in 3 patients. There are still 3 patients under treatment: one of the two that were cured suffers from loss of the physiological lumbar lordosis and the other lost a vertebral body and presents a mild residual

  11. Penser Système : Découvrir nos modèles d'organisation

    NARCIS (Netherlands)

    Bryan, B.; Goodman, M.; Schaveling, J.

    2011-01-01

    Pourquoi le travail s’accumule-t-il sur nos bureaux alors que nous travaillons de plus en plus? Parfois « nos solutions » aggravent nos problèmes. Comment pouvons-nous éviter ces paradoxes ? Penser système donne de nouvelles perspectives dans des situations complexes. Cela vous permettra de

  12. The effect of high protein diet and exercise on irisin, eNOS, and iNOS expressions in kidney.

    Science.gov (United States)

    Tastekin, Ebru; Palabiyik, Orkide; Ulucam, Enis; Uzgur, Selda; Karaca, Aziz; Vardar, Selma Arzu; Yilmaz, Ali; Aydogdu, Nurettin

    2016-08-01

    Long-term effects of high protein diets (HPDs) on kidneys are still not sufficiently studied. Irisin which increases oxygen consumption and thermogenesis in white fat cells was shown in skeletal muscles and many tissues. Nitric oxide synthases (NOS) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. We aimed to investigate the effects of HPD, irisin and NO expression in kidney and relation of them with exercise and among themselves. Animals were grouped as control, exercise, HPD and exercise combined with HPD (exercise-HPD). Rats were kept on a HPD for 5 weeks and an exercise program was given them as 5 exercise and 2 rest days per week exercising on a treadmill with increasing speed and angle. In our study, while HPD group had similar total antioxidant capacity (TAC) levels with control group, exercise and exercise-HPD groups had lower levels (p highly selective and quite clear in this study. Effects of exercise and HPD on kidney should be evaluated with different exercise protocols and contents of the diet. İrisin, eNOS, and iNOS staining localizations should be supported with various research studies.

  13. Co-expression of the Thermotoga neapolitana aglB gene with an upstream 3'-coding fragment of the malG gene improves enzymatic characteristics of recombinant AglB cyclomaltodextrinase.

    Science.gov (United States)

    Lunina, Natalia A; Agafonova, Elena V; Chekanovskaya, Lyudmila A; Dvortsov, Igor A; Berezina, Oksana V; Shedova, Ekaterina N; Kostrov, Sergey V; Velikodvorskaya, Galina A

    2007-07-01

    A cluster of Thermotoga neapolitana genes participating in starch degradation includes the malG gene of sugar transport protein and the aglB gene of cyclomaltodextrinase. The start and stop codons of these genes share a common overlapping sequence, aTGAtg. Here, we compared properties of expression products of three different constructs with aglB from T. neapolitana. The first expression vector contained the aglB gene linked to an upstream 90-bp 3'-terminal region of the malG gene with the stop codon overlapping with the start codon of aglB. The second construct included the isolated coding sequence of aglB with two tandem potential start codons. The expression product of this construct in Escherichia coli had two tandem Met residues at its N terminus and was characterized by low thermostability and high tendency to aggregate. In contrast, co-expression of aglB and the 3'-terminal region of malG (the first construct) resulted in AglB with only one N-terminal Met residue and a much higher specific activity of cyclomaltodextrinase. Moreover, the enzyme expressed by such a construct was more thermostable and less prone to aggregation. The third construct was the same as the second one except that it contained only one ATG start codon. The product of its expression had kinetic and other properties similar to those of the enzyme with only one N-terminal Met residue.

  14. la originalidad del regionalismo castellano y leonés en 1931 y 1932. ¿Un proyecto genuino o la necesidad de asumir un mal menor?

    Directory of Open Access Journals (Sweden)

    Luis Felipe PALACIOS

    2016-05-01

    Full Text Available Entre 1931 y 1932, como ocurrió en otras regiones españolas, Castilla y León asistió al resurgir de un regionalismo que hasta la fecha apenas había dado síntomas de vitalidad. A partir de esta realidad la pregunta que surge es si la renovada actividad regionalista castellano y leonesa reflejaba la actualización de un sentir originario y bien arraigado o era una respuesta obligada por el avance que estaba logrando el catalanismo durante el período considerado y por el nuevo modelo de organización territorial del Estado que definió la nueva Constitución de 1931. A la vista del comportamiento y manifestaciones de las fuerzas políticas, sociales e institucionales castellano y leonesas, podemos concluir que el regionalismo castellano y leonés no respondió a un sentimiento genuino y propio sino que fue la consecuencia de la necesidad de asumir un mal menor, de la adaptación a un nuevo modelo territorial no deseado.

  15. In vivo subcellular localization of Mal de Rio Cuarto virus (MRCV) non-structural proteins in insect cells reveals their putative functions

    Energy Technology Data Exchange (ETDEWEB)

    Maroniche, Guillermo A.; Mongelli, Vanesa C.; Llauger, Gabriela; Alfonso, Victoria; Taboga, Oscar [Instituto de Biotecnologia, CICVyA, Instituto Nacional de Tecnologia Agropecuaria (IB-INTA), Las cabanas y Los Reseros s/n. Hurlingham Cp 1686, Buenos Aires (Argentina); Vas, Mariana del, E-mail: mdelvas@cnia.inta.gov.ar [Instituto de Biotecnologia, CICVyA, Instituto Nacional de Tecnologia Agropecuaria (IB-INTA), Las cabanas y Los Reseros s/n. Hurlingham Cp 1686, Buenos Aires (Argentina)

    2012-09-01

    The in vivo subcellular localization of Mal de Rio Cuarto virus (MRCV, Fijivirus, Reoviridae) non-structural proteins fused to GFP was analyzed by confocal microscopy. P5-1 showed a cytoplasmic vesicular-like distribution that was lost upon deleting its PDZ binding TKF motif, suggesting that P5-1 interacts with cellular PDZ proteins. P5-2 located at the nucleus and its nuclear import was affected by the deletion of its basic C-termini. P7-1 and P7-2 also entered the nucleus and therefore, along with P5-2, could function as regulators of host gene expression. P6 located in the cytoplasm and in perinuclear cloud-like inclusions, was driven to P9-1 viroplasm-like structures and co-localized with P7-2, P10 and {alpha}-tubulin, suggesting its involvement in viroplasm formation and viral intracellular movement. Finally, P9-2 was N-glycosylated and located at the plasma membrane in association with filopodia-like protrusions containing actin, suggesting a possible role in virus cell-to-cell movement and spread.

  16. Linfoma Nasal de Células T/Natural Killer Extranodal Refractario Mal Diagnosticado, Tratado de Manera Exitosa: Informe de Caso.

    Science.gov (United States)

    Saavedra Ramírez, José Domingo

    2017-01-01

    El linfoma de células T/natural killer extranodal ("extranodal natural killer/T-cell lymphoma", ENKL) nasal es un linfoma no Hodgkin (LNH) agresivo y poco común para el cual no se ha establecido un tratamiento de referencia claro, especialmente en el escenario de la enfermedad recidivante/refractaria. Debido a su rareza, no se han llevado a cabo ensayos aleatorizados específicamente en ENKL nasal; sin embargo, los informes de caso y las series de caso pequeñas ofrecen un conocimiento importante sobre nuevos tratamientos potenciales. Presentamos el informe de caso de un paciente con ENKL nasal (previamente mal diagnosticado como una sinusitis crónica recidivante) en quien la enfermedad progresó durante la quimioterapia con múltiples agentes pero respondió al tratamiento de segunda línea con pralatrexato como agente único. Analizamos opciones de tratamiento para el ENKL nasal recidivante/refractario y sugerimos que el pralatrexato se evalúe más a fondo en este escenario clínico.

  17. The etiology, risk factors, and interactions of enteric infections and malnutrition and the consequences for child health and development study (MAL-ED): description of the Tanzanian site.

    Science.gov (United States)

    Mduma, Estomih R; Gratz, Jean; Patil, Crystal; Matson, Kristine; Dakay, Mary; Liu, Sarah; Pascal, John; McQuillin, Lauren; Mighay, Emmanuel; Hinken, Elizabeth; Ernst, Alexandra; Amour, Caroline; Mvungi, Regisiana; Bayyo, Eliwaza; Zakaria, Yeconia; Kivuyo, Sokoine; Houpt, Eric R; Svensen, Erling

    2014-11-01

    The Haydom, Tanzania, site (TZH) of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) Study is in north-central Tanzania, 300 km from the nearest urban center. TZH is in a remote rural district where most of the population are agropastoralists and grow maize as the staple food. The average household size is 7. The average woman achieves a parity of 6 and has 1 child death. Socioeconomic indicators are poor, with essentially no household having access to electricity, piped water, or improved sanitary facilities (compared with 14%, 7%, and 12%, respectively, reported nationally). The Demographic Health Survey Tanzania 2004 indicated that the region had high rates of stunting and underweight (40% and 31% of children aged child mortality rate of 5.8%. Human immunodeficiency virus prevalence among 18-month-old children is rural African population with profound poverty and malnutrition, but a strong community-based research infrastructure. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  18. INTERVENCIÓN FAMILIAR PARA EL MANEJO PSICOLÓGICO EN PACIENTES ONCOLÓGICOS CON MAL PRONÓSTICO EN EL HOSPITAL DE LA MISERICORDIA

    Directory of Open Access Journals (Sweden)

    Martha Restrepo Forero

    2004-06-01

    Full Text Available Se diseñó un programa fundamentado en el modelo cognitivo conductual de Inoculación de Estrés e intervención en duelo anticipatorio basado en cuatro tareas. El programa fue aplicado a tres pacientes con mal pronóstico del Servicio de Oncohematología del Hospital de la Misericordia y a sus familias. Por medio de estudio de caso, se describieron factores de riesgo y de protección así como respuestas frente a dicha intervención. El análisis cualitativo de casos arrojó la descripción de respuestas a pérdidas previas no elaboradas, pautas de comunicación deficiente en uno de los casos, y reconocimiento de apoyo al interior de cada familia. Según el reporte de los participantes, la intervención permitió la expresión de sentimientos, la reflexión sobre el sentido de la vida, incremento de posibilidades y habilidades de comunicación y orientación hacia la solución de problemas y toma de decisiones.

  19. Mal de Río Cuarto Virus Infection Triggers the Production of Distinctive Viral-Derived siRNA Profiles in Wheat and Its Planthopper Vector.

    Science.gov (United States)

    de Haro, Luis A; Dumón, Analía D; Mattio, María F; Argüello Caro, Evangelina Beatriz; Llauger, Gabriela; Zavallo, Diego; Blanc, Hervé; Mongelli, Vanesa C; Truol, Graciela; Saleh, María-Carla; Asurmendi, Sebastián; Del Vas, Mariana

    2017-01-01

    Plant reoviruses are able to multiply in gramineae plants and delphacid vectors encountering different defense strategies with unique features. This study aims to comparatively assess alterations of small RNA (sRNA) populations in both hosts upon virus infection. For this purpose, we characterized the sRNA profiles of wheat and planthopper vectors infected by Mal de Río Cuarto virus (MRCV, Fijivirus, Reoviridae ) and quantified virus genome segments by quantitative reverse transcription PCR We provide evidence that plant and insect silencing machineries differentially recognize the viral genome, thus giving rise to distinct profiles of virus-derived small interfering RNAs (vsiRNAs). In plants, most of the virus genome segments were targeted preferentially within their upstream sequences and vsiRNAs mapped with higher density to the smaller genome segments than to the medium or larger ones. This tendency, however, was not observed in insects. In both hosts, vsiRNAs were equally derived from sense and antisense RNA strands and the differences in vsiRNAs accumulation did not correlate with mRNAs accumulation. We also established that the piwi-interacting RNA (piRNA) pathway was active in the delphacid vector but, contrary to what is observed in virus-infected mosquitoes, virus-specific piRNAs were not detected. This work contributes to the understanding of the silencing response in insect and plant hosts.

  20. Transmisión del Mal de Río Cuarto virus por ninfas de primer y tercer estadio de Delphacodes kuscheli Transmission of Mal de Río Cuarto virus by first and third-instar nymphs of Delphacodes kuscheli

    Directory of Open Access Journals (Sweden)

    Joel Arneodo

    2005-02-01

    Full Text Available Se comparó la capacidad de ninfas de primer y tercer estadío de Delphacodes kuscheli Fennah (Hemiptera: Delphacidae para adquirir y posteriormente transmitir el Mal de Río Cuarto virus (MRCV, bajo condiciones controladas. Ninfas I y III avirulíferas se alimentaron separadamente de plantas de trigo infectadas durante 48 horas, para luego ser colocadas en subgrupos de tres individuos sobre plantas de trigo sanas. Se realizaron transmisiones seriales utilizando períodos de inoculación de 24 horas. Ambos estadií os lograron adquirir y transmitir el MRCV, pero se evidenció una mayor cantidad de subgrupos infectivos cuando la adquisición se efectuó como ninfas I, así como una disminución significativa en la duración del período de latencia del virus respecto de los insectos que adquirieron el MRCV durante el tercer estadio ninfal.The ability of first and third-instar Delphacodes kuscheli Fennah (Hemiptera: Delphacidae nymphs to acquire and transmit Mal de Río Cuarto virus (MRCV, under controlled conditions, was investigated. First and third-instar nymphs were allowed acquisition feeding separately on infected wheat plants for 48 hours. The insects were then placed in groups of three for serial transmissions to healthy wheat plants, using inoculation periods of 24 hours. Both instars of D. kuscheli were demonstrated to acquire and subsequently transmit the virus. Nevertheless, transmission trials showed highest transmission efficiency and shortest latent period when MRCV was acquired by first-instar nymphs.

  1. Spatial analysis for stratification of priority malaria control areas, Mato Grosso State, Brazil Análise espacial na estratificação de áreas prioritárias para o controle da malária no Estado de Mato Grosso, Brasil

    Directory of Open Access Journals (Sweden)

    Marina Atanaka-Santos

    2007-05-01

    Full Text Available The goal of this study was to stratify priority areas for malaria control in the State of Mato Grosso, Brazil, based on spatial analysis. The variables used were: Annual Parasite Index (API, Plasmodium falciparum/Plasmodium vivax ratio, population variation, number of families settled, and percent of deforested area. The Moran's I and Local Moran Test were applied, visualized with the Box Map and Moran Map, for 1986- 1991, 1992-1997, and 1998-2003. Box Map identified areas with high, low, and intermediate priority for control, and Moran Map identified municipalities with significant autocorrelation. In the high priority area, located in the North of Mato Grosso, malaria incidence decreased drastically despite the increase in the number of municipalities from the first to the last period. Other municipalities were added to the lower priority area, from the Southeast, Southwest, and Central-South of the State. The intermediate priority area was located along the border with neighboring States and municipalities classified as high and low priority. Spatial analysis showed the importance of the neighboring phenomenon between municipalities in defining priority areas, thus highlighting the technique's advantages for use in malaria control and surveillance.Pautado em técnicas de análise espacial, analisou-se a estratificação de áreas prioritárias para controle da malária no Estado de Mato Grosso, Brasil. Trabalhou-se Incidência Parasitária Anual, relação Plasmodium falciparum/Plasmodium vivax, variação populacional, número de famílias assentadas e percentuais da área desmatada. Foram utilizados os testes de I de Moran e Moran Local, visualizadas pelo Box Map e Moran Map, nos períodos de: 1986 a 1991, 1992 a 1997 e 1998 a 2003. Pelo Box Map identificaram-se áreas de prioridade maior, menor e intermediária, e pelo Moran Map localizaram-se municípios com autocorrelação estatisticamente significante. Na área de maior prioridade

  2. Expression of Beta-catenin, COX-2 and iNOS in Colorectal Cancer: Relevance of COX-2 and iNOS Inhibitors for Treatment in Malaysia

    Directory of Open Access Journals (Sweden)

    Seok Kwan Hong

    2004-01-01

    Conclusions: The accumulation of β-catenin does not seem to be sufficient to activate pathways that lead to increased COX-2 and iNOS expression. A high proportion of colorectal cancers were found to express COX-2 and a significant number produced iNOS, suggesting that their inhibitors may be potentially useful as chemotherapeutic agents in the management of colorectal cancer.

  3. Using a Professional Development Program for Enhancing Chilean Biology Teachers' Understanding of Nature of Science (NOS) and Their Perceptions about Using History of Science to Teach NOS

    Science.gov (United States)

    Pavez, José M.; Vergara, Claudia A.; Santibañez, David; Cofré, Hernán

    2016-01-01

    A number of authors have recognized the importance of understanding the nature of science (NOS) for scientific literacy. Different instructional strategies such as decontextualized, hands-on inquiry, and history of science (HOS) activities have been proposed for teaching NOS. This article seeks to understand the contribution of HOS in enhancing…

  4. Beer elicits vasculoprotective effects through Akt/eNOS activation.

    Science.gov (United States)

    Vilahur, Gemma; Casani, Laura; Mendieta, Guiomar; Lamuela-Raventos, Rosa M; Estruch, Ramon; Badimon, Lina

    2014-12-01

    There is controversy regarding the effect of alcohol beverage intake in vascular vasodilatory function in peripheral arteries. The effects of beer intake in coronary vasodilation remain unknown. We investigated whether regular beer intake (alcohol and alcohol-free) protects against hypercholesterolaemia-induced coronary endothelial dysfunction and the mechanisms behind this effect. Pigs were fed 10 days: (i) a Western-type hypercholesterolaemic diet (WD); (ii) WD+low-dose beer (12·5 g alcohol/day); (iii) WD+moderate-dose beer (25 g alcohol/day); or (iv) WD+moderate-dose alcohol-free-beer (0·0 g alcohol/day). Coronary responses to endothelium-dependent vasoactive drugs (acetylcholine: receptor mediated; calcium ionophore-A23189: nonreceptor mediated), endothelium-independent vasoactive drug (SNP) and L-NMMA (NOS-antagonist) were evaluated in the LAD coronary artery by flow Doppler. Coronary Akt/eNOS activation, MCP-1 expression, oxidative DNA damage and superoxide production were assessed. Lipid profile, lipoproteins resistance to oxidation and urinary isoxanthohumol concentration were evaluated. Alcoholic and nonalcoholic beer intake prevented WD-induced impairment of receptor- and non-receptor-operated endothelial-dependent coronary vasodilation. All animals displayed a similar vasodilatory response to SNP and L-NMMA blunted all endothelial-dependent vasorelaxation responses. Haemodynamic parameters remained unchanged. Coronary arteries showed lower DNA damage and increased Akt/eNOS axis activation in beer-fed animals. Animals taking beer showed HDL with higher antioxidant capacity, higher LDL resistance to oxidation and increased isoxanthohumol levels. Weight, lipids levels, liver enzymes and MCP-1 expression were not affected by beer intake. Non-alcoholic-related beer components protect against hyperlipemia-induced coronary endothelial dysfunction by counteracting vascular oxidative damage and preserving the Akt/eNOS pathway. Light-to-moderate beer

  5. A Fast Response Capability within NOAA/NOS/CO-OPS

    Science.gov (United States)

    2007-01-01

    A Fast Response Capability within NOAA/NOS/CO-OPS P. B. Burke NOAA/National Ocean Service/CO-OPS 1305 East-West Hwy. Silver Spring, MD 20910...USA pat.burke@noaa.gov T. Graff NOAA/National Ocean Service/CO-OPS 1305 East-West Hwy. Silver Spring, MD 20910 USA tammy.graff@noaa.gov... flotation hull, an instrumentation tower mounted atop the hull and a current meter mount with a mooring attachment. The triangular tower housed two

  6. O trabalho de vigilância nos centros comerciais

    OpenAIRE

    Gadea,Charles; Cruz,Sofia Alexandra

    2013-01-01

    Este artigo visa escrutinar em termos sociológicos a atividade profissional dos vigilantes nos centros comerciais, analisando o tipo de competências profissionais exigidas, a configuração da hierarquia profissional da vigilância e sua articulação com a comunicação cotidiana entre os vigilantes e, por fim, os desafios e dilemas subjacentes ao ato de vigiar. A pesquisa baseia-se metodologicamente em dados obtidos a partir de entrevistas semidiretivas a vigilantes e observação direta dos seus es...

  7. Medo de que? : uma historia do horror nos filmes brasileiros

    OpenAIRE

    Laura Loguercio Canepa

    2008-01-01

    Resumo: Neste trabalho, examinam-se as manifestações do gênero horror nos longas-metragens sonoros brasileiros realizados entre 1937 e 2007, elaborando-se um panorama histórico desses filmes, desde os primeiros registros cinematográficos deste gênero de ficção no cinema nacional até os mais recentes, e propondo-se um modelo descritivo para as configurações do horror ficcional no cinema brasileiro. Para isso, partiu-se dos estudos de gêneros cinematográficos, de história do cinema mundial e de...

  8. Estudo histopatológico de lesões ateroscleróticas em suínos de raça Alentejana Histopathological study of atherosclerotic lesions in Alentejano pigs

    Directory of Open Access Journals (Sweden)

    A. Ramos

    2007-01-01

    Full Text Available Neste trabalho experimental procedeu-se à medição da espessura e à caracterização histológica de lesões ateroscleróticas, em suínos de raça Alentejana, procurando-se estabelecer uma relação entre estas e os valores dos parâmetros sanguíneos associados ao desenvolvimento deste processo patológico. As concentrações plasmáticas de triacilgliceróis, fosfolípidos, colesterol total, colesterol livre, LDLc e HDLc foram determinadas por métodos enzimáticos. Foram também feitas análises histopatológicas a amostras da artéria coronária esquerda. Os animais foram divididos em 2 grupos de 6 indivíduos cada: Grupo I, com elevada colesterolémia (4,25 mmol/L e Grupo II, com níveis normais (2,53 mmol/L. Os valores do ganho médio diário (GMD dos dois grupos foram semelhantes. Os animais do Grupo I apresentaram valores significativamente mais elevados (P=0,001 para: colesterol total, colesterol livre, colesterol esterificado e LDLc. A área de lesão foi significativamente superior (P=0,05 no Grupo I. Verificou-se uma relação linear entre a área de lesão (fases iniciais do tipo I e II e os teores plasmáticos de colesterol total, de LDLc e de colesterol livre, o que sugere a influência destes parâmetros na dimensão da área de lesão. Os resultados deste trabalho sugerem que os suínos de raça Alentejana podem desenvolver lesões ateroscleróticas ao longo do seu ciclo de vida, tal como o observado em humanos e outras raças de suínos. Estas lesões estão associadas a hipercolesterolemia que poderão ser devidas a mutações genéticas em apolipoproteínas, sistemas enzimáticos ou receptores. São necessários estudos futuros, quer a nível histológico quer a nível de biologia molecular, para um maior aprofundamento do conhecimento das lesões ateroscleróticas em suínos de raça Alentejana.The present study aimed to assess the histopathological characterization of atherosclerotic lesions in Alentejano pigs, and to

  9. Non-ergodicity of Nosé–Hoover dynamics

    International Nuclear Information System (INIS)

    Legoll, Frédéric; Luskin, Mitchell; Moeckel, Richard

    2009-01-01

    The Nosé–Hoover dynamics is a deterministic method that is commonly used to sample the canonical Gibbs measure. This dynamics extends the physical Hamiltonian dynamics by the addition of a 'thermostat' variable, which is coupled nonlinearly with the physical variables. The accuracy of the method depends on the dynamics being ergodic. Numerical experiments have been published earlier that are consistent with non-ergodicity of the dynamics for some model problems. The authors recently proved the non-ergodicity of the Nosé–Hoover dynamics for the one-dimensional harmonic oscillator. In this paper, this result is extended to non-harmonic one-dimensional systems. We also show that, for some multidimensional systems, the averaged dynamics for the limit of infinite thermostat 'mass' has many invariants, thus giving theoretical support for either non-ergodicity or slow ergodization. Numerical experiments for a two-dimensional central force problem and the one-dimensional pendulum problem give evidence for non-ergodicity

  10. Ergodicity of the Stochastic Nosé-Hoover Heat Bath

    Science.gov (United States)

    Wei Chung Lo,; Baowen Li,

    2010-07-01

    We numerically study the ergodicity of the stochastic Nosé-Hoover heat bath whose formalism is based on the Markovian approximation for the Nosé-Hoover equation [J. Phys. Soc. Jpn. 77 (2008) 103001]. The approximation leads to a Langevin-like equation driven by a fluctuating dissipative force and multiplicative Gaussian white noise. The steady state solution of the associated Fokker-Planck equation is the canonical distribution. We investigate the dynamics of this method for the case of (i) free particle, (ii) nonlinear oscillators and (iii) lattice chains. We derive the Fokker-Planck equation for the free particle and present approximate analytical solution for the stationary distribution in the context of the Markovian approximation. Numerical simulation results for nonlinear oscillators show that this method results in a Gaussian distribution for the particles velocity. We also employ the method as heat baths to study nonequilibrium heat flow in one-dimensional Fermi-Pasta-Ulam (FPU-β) and Frenkel-Kontorova (FK) lattices. The establishment of well-defined temperature profiles are observed only when the lattice size is large. Our results provide numerical justification for such Markovian approximation for classical single- and many-body systems.

  11. A sociologia funcionalista nos estudos organizacionais: foco em Durkheim

    Directory of Open Access Journals (Sweden)

    Augusto Cabral

    Full Text Available O tema que estrutura este ensaio é o da sociologia funcionalista, particularmente em termos de sua influência nos estudos organizacionais. O seu foco de análise é duplo. Em um primeiro momento, as obras de Durkheim. Em um segundo momento, o impacto e a supremacia dos enfoques funcionalistas nos estudos organizacionais. Embora seus segmentos estejam inter-relacionados, ele é composto de quatro partes. Na primeira, é feita uma análise histórica da emergência e sistematização das ciências sociais, de modo a traçar sua evolução até o surgimento dos trabalhos de Durkheim. Na segunda, tomando como referencial a obra de Burrell e Morgan (1979, é estudado o paradigma funcionalista em termos de sua origem e expoentes, com destaque para Comte e Spencer, visando chegar a uma compreensão inicial do pensamento de Durkheim e de sua sociologia. Na terceira, a vida e as principais obras de Durkheim são sumariadas e discutidas. Por fim, o status atual dos estudos organizacionais -vistos como um conjunto impreciso, elástico e eclético de teorias e pesquisas sociais voltados para os problemas das organizações -é analisado em termos de seus pressupostos epistemológicos e ontológicos subjacentes, como meio de explicitar a supremacia dos enfoques positivistas-funcionalistas.

  12. Zinc regulates iNOS-derived nitric oxide formation in endothelial cells

    Directory of Open Access Journals (Sweden)

    Miriam M. Cortese-Krott

    2014-01-01

    Full Text Available Aberrant production of nitric oxide (NO by inducible NO synthase (iNOS has been implicated in the pathogenesis of endothelial dysfunction and vascular disease. Mechanisms responsible for the fine-tuning of iNOS activity in inflammation are still not fully understood. Zinc is an important structural element of NOS enzymes and is known to inhibit its catalytical activity. In this study we aimed to investigate the effects of zinc on iNOS activity and expression in endothelial cells. We found that zinc down-regulated the expression of iNOS (mRNA+protein and decreased cytokine-mediated activation of the iNOS promoter. Zinc-mediated regulation of iNOS expression was due to inhibition of NF-κB transactivation activity, as determined by a decrease in both NF-κB-driven luciferase reporter activity and expression of NF-κB target genes, including cyclooxygenase 2 and IL-1β. However, zinc did not affect NF-κB translocation into the nucleus, as assessed by Western blot analysis of nuclear and cytoplasmic fractions. Taken together our results demonstrate that zinc limits iNOS-derived high output NO production in endothelial cells by inhibiting NF-κB-dependent iNOS expression, pointing to a role of zinc as a regulator of iNOS activity in inflammation.

  13. iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants.

    Science.gov (United States)

    Cassini-Vieira, Puebla; Araújo, Fernanda Assis; da Costa Dias, Filipi Leles; Russo, Remo Castro; Andrade, Silvia Passos; Teixeira, Mauro Martins; Barcelos, Luciola Silva

    2015-01-01

    There is considerable interest in implantation techniques and scaffolds for tissue engineering and, for safety and biocompatibility reasons, inflammation, angiogenesis, and fibrosis need to be determined. The contribution of inducible nitric oxide synthase (iNOS) in the regulation of the foreign body reaction induced by subcutaneous implantation of a synthetic matrix was never investigated. Here, we examined the role of iNOS in angiogenesis, inflammation, and collagen deposition induced by polyether-polyurethane synthetic implants, using mice with targeted disruption of the iNOS gene (iNOS(-/-)) and wild-type (WT) mice. The hemoglobin content and number of vessels were decreased in the implants of iNOS(-/-) mice compared to WT mice 14 days after implantation. VEGF levels were also reduced in the implants of iNOS(-/-) mice. In contrast, the iNOS(-/-) implants exhibited an increased neutrophil and macrophage infiltration. However, no alterations were observed in levels of CXCL1 and CCL2, chemokines related to neutrophil and macrophage migration, respectively. Furthermore, the implants of iNOS(-/-) mice showed boosted collagen deposition. These data suggest that iNOS activity controls inflammation, angiogenesis, and fibrogenesis in polyether-polyurethane synthetic implants and that lack of iNOS expression increases foreign body reaction to implants in mice.

  14. Zinc regulates iNOS-derived nitric oxide formation in endothelial cells

    Science.gov (United States)

    Cortese-Krott, Miriam M.; Kulakov, Larissa; Opländer, Christian; Kolb-Bachofen, Victoria; Kröncke, Klaus-D.; Suschek, Christoph V.

    2014-01-01

    Aberrant production of nitric oxide (NO) by inducible NO synthase (iNOS) has been implicated in the pathogenesis of endothelial dysfunction and vascular disease. Mechanisms responsible for the fine-tuning of iNOS activity in inflammation are still not fully understood. Zinc is an important structural element of NOS enzymes and is known to inhibit its catalytical activity. In this study we aimed to investigate the effects of zinc on iNOS activity and expression in endothelial cells. We found that zinc down-regulated the expression of iNOS (mRNA+protein) and decreased cytokine-mediated activation of the iNOS promoter. Zinc-mediated regulation of iNOS expression was due to inhibition of NF-κB transactivation activity, as determined by a decrease in both NF-κB-driven luciferase reporter activity and expression of NF-κB target genes, including cyclooxygenase 2 and IL-1β. However, zinc did not affect NF-κB translocation into the nucleus, as assessed by Western blot analysis of nuclear and cytoplasmic fractions. Taken together our results demonstrate that zinc limits iNOS-derived high output NO production in endothelial cells by inhibiting NF-κB-dependent iNOS expression, pointing to a role of zinc as a regulator of iNOS activity in inflammation. PMID:25180171

  15. 78 FR 49305 - Luminant Generation Company LLC, Comanche Peak Nuclear Power Plant, Unit Nos. 1 and 2...

    Science.gov (United States)

    2013-08-13

    ... NUCLEAR REGULATORY COMMISSION [Docket Nos. 50-445 and 50-446; NRC-2013-0182] Luminant Generation Company LLC, Comanche Peak Nuclear Power Plant, Unit Nos. 1 and 2; Application for Amendment to Facility... Operating License Nos. NPF-87 and NPF-89 for the Comanche Peak Nuclear Power Plant, Unit Nos. 1 and 2...

  16. Dynamics and Trends in Fecal Biomarkers of Gut Function in Children from 1–24 Months in the MAL-ED Study

    Science.gov (United States)

    McCormick, Benjamin J. J.; Lee, Gwenyth O.; Seidman, Jessica C.; Haque, Rashidul; Mondal, Dinesh; Quetz, Josiane; Lima, Aldo A. M.; Babji, Sudhir; Kang, Gagandeep; Shrestha, Sanjaya K.; Mason, Carl J.; Qureshi, Shahida; Bhutta, Zulfiqar A.; Olortegui, Maribel Paredes; Yori, Pablo Peñataro; Samie, Amidou; Bessong, Pascal; Amour, Caroline; Mduma, Estomih; Patil, Crystal L.; Guerrant, Richard L.; Lang, Dennis R.; Gottlieb, Michael; Caulfield, Laura E.; Kosek, Margaret N.

    2017-01-01

    Growth and development shortfalls that are disproportionately prevalent in children living in poor environmental conditions are postulated to result, at least in part, from abnormal gut function. Using data from The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) longitudinal cohort study, we examine biomarkers of gut inflammation and permeability in relation to environmental exposures and feeding practices. Trends in the concentrations of three biomarkers, myeloperoxidase (MPO), neopterin (NEO), and α-1-antitrypsin (AAT), are described from fecal samples collected during the first 2 years of each child's life. A total of 22,846 stool samples were processed during the longitudinal sampling of 2,076 children 0–24 months of age. Linear mixed models were constructed to examine the relationship between biomarker concentrations and recent food intake, symptoms of illness, concurrent enteropathogen infection, and socioeconomic status. Average concentrations of MPO, NEO, and AAT were considerably higher than published references for healthy adults. The concentration of each biomarker tended to decrease over the first 2 years of life and was highly variable between samples from each individual child. Both MPO and AAT were significantly elevated by recent breast milk intake. All three biomarkers were associated with pathogen presence, although the strength and direction varied by pathogen. The interpretation of biomarker concentrations is subject to the context of their collection. Herein, we identify that common factors (age, breast milk, and enteric infection) influence the concentration of these biomarkers. Within the context of low- and middle-income communities, we observe concentrations that indicate gut abnormalities, but more appropriate reference standards are needed. PMID:27994110

  17. Malófagos (Phthiraptera, Amblycera, Ischnocera em aves cativas no sudeste do Brasil Chewing lice (Phthiraptera, Amblycera, Ischnocera on captive birds in southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Salete Oliveira da Silva

    2009-01-01

    Full Text Available Foram identificadas 12 espécies de malófagos no Parque Zoológico Municipal Quinzinho de Barros, Sorocaba e Fundação Jardim Zoológico, Rio de Janeiro. Ciconiphilus pectiniventris em Cygnus atratus (Anseriformes, Anatidae; Kurodaia sp. em Buteo albicaudatus (Falconiformes, Accipitridae; Degeeriella sp. em Falco sparverius (Falconiformes, Falconidae; Colpocephalum sp. e Goniocotes parviceps em Pavo cristatus (Galliformes, Phasianidae; Goniodes pavonis em Rhea americana (Rheiformes, Rheidae; Colpocephalum cristatae e Heptapsogaster sp. em Cariama cristata (Gruiformes, Cariamidae; Austrophilopterus cancellosus em Ramphastos dicolorus (Piciformes, Ramphastidae; Strigiphilus crucigerus em Otus choliba (Strigiformes, Strigidae; Kurodaia sp. em Rhinoptynx clamator (Strigiformes, Strigidae e Colpocephalum pectinatum em Speotyto cunicularia (Strigiformes, Strigidae. As relações parasito hospedeiros em Strigiformes são novas no Brasil.Twelve chewing lice species were identified in Parque Zoológico Municipal Quinzinho de Barros, Sorocaba and Fundação Jardim Zoológico, Rio de Janeiro. The parasites found were: Ciconiphilus pectiniventris in Cygnus atratus (Anseriformes, Anatidae; Kurodaia sp. in Buteo albicaudatus (Falconiformes, Accipitridae; Degeeriella sp. in Falco sparverius (Falconiformes, Falconidae; Colpocephalum sp. and Goniocotes parviceps in Pavo cristatus (Galliformes, Phasianidae; Goniodes pavonis in Rhea americana (Rheiformes, Rheidae; Colpocephalum cristatae and Heptapsogaster sp. in Cariama cristata (Gruiformes, Cariamidae; Austrophilopterus cancellosus in Ramphastos dicolorus (Piciformes, Ramphastidae; Strigiphilus crucigerus in Otus choliba (Strigiformes, Strigidae; Kurodaia sp. in Rhinoptynx clamator (Strigiformes, Strigidae and Colpocephalum pectinatum in Speotyto cunicularia (Strigiformes, Strigidae. The host-lice relationships are new in Strigiformes in Brazil.

  18. Avaliação da eficácia do artesunato associado à tetraciclina na terapêutica da malária falciparum

    Directory of Open Access Journals (Sweden)

    Villalobos Salcedo Juan Miguel

    1997-01-01

    Full Text Available Realizou-se um ensaio clínico, randomizado e controlado, comparando o artesunato com o quinino e a mefloquina, em casos de malária não grave. Foram tratados 42 pacientes em regime de internação e o seguimento durou 28 dias. Realizou-se exame de gota espessa cada 12 horas até sua negativação, hemograma e bioquímica sanguínea, pré e pós-tratamento. A média da parasitemia inicial foi 42.568 parasitas/ml. Vinte e seis pacientes foram acompanhados durante 28 dias e 16 durante menos de 28 dias. Um paciente de cada grupo apresentou R I tardia e um paciente do grupo do quinino apresentou R III. As porcentagens de cura foram 88,8%, 85,7% e 81,8% para o artesunato, a mefloquina e o quinino, respectivamente, sem mostrar diferença significativa. O tempo de desaparecimento da febre não mostrou diferença significativa entre os grupos. O grupo do artesunato teve um tempo menor de clareamento da parasitemia (37,33 ± 11,52 horas quando comparado com o quinino (65,25 ± 17,44 horas, sendo estatisticamente significativa (p = 0,0016. O grupo da mefloquina (58,9 ± 16,68 horas não mostrou diferença com os outros grupos. Não se apresentaram efeitos adversos importantes em nenhum dos esquemas usados, sendo bem tolerados pelos pacientes.

  19. Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs)

    International Nuclear Information System (INIS)

    Morita, Tsuyoshi; Mayanagi, Taira; Sobue, Kenji

    2007-01-01

    RhoA is a crucial regulator of stress fiber and focal adhesion formation through the activation of actin nucleation and polymerization. It also regulates the nuclear translocation of myocardin-related transcription factor-A and -B (MRTF-A/B, MAL or MKL 1/2), which are co-activators of serum response factor (SRF). In dominant-negative MRTF-A (DN-MRTF-A)-expressing NIH 3T3 cell lines, the expressions of several cytoskeletal/focal adhesion genes were down-regulated, and the formation of stress fiber and focal adhesion was severely diminished. MRTF-A/B-knockdown cells also exhibited such cytoskeletal defects. In reporter assays, both RhoA and MRTF-A enhanced promoter activities of these genes in a CArG-box-dependent manner, and DN-MRTF-A inhibited the RhoA-mediated activation of these promoters. In dominant-negative RhoA (RhoA-N19)-expressing NIH 3T3 cell lines, the nuclear translocation of MRTF-A/B was predominantly prevented, resulting in the reduced expression of cytoskeletal/focal adhesion proteins. Further, constitutive-active MRTF-A/B increased the expression of endogenous cytoskeletal/focal adhesion proteins, and thereby rescued the defective phenotype of stress fibers and focal adhesions in RhoA-N19 expressing cells. These results indicate that MRTF-A/B act as pivotal mediators of stress fiber and focal adhesion formation via the transcriptional regulation of a subset of cytoskeletal/focal adhesion genes

  20. Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study.

    Science.gov (United States)

    Amour, Caroline; Gratz, Jean; Mduma, Estomih; Svensen, Erling; Rogawski, Elizabeth T; McGrath, Monica; Seidman, Jessica C; McCormick, Benjamin J J; Shrestha, Sanjaya; Samie, Amidou; Mahfuz, Mustafa; Qureshi, Shahida; Hotwani, Aneeta; Babji, Sudhir; Trigoso, Dixner Rengifo; Lima, Aldo A M; Bodhidatta, Ladaporn; Bessong, Pascal; Ahmed, Tahmeed; Shakoor, Sadia; Kang, Gagandeep; Kosek, Margaret; Guerrant, Richard L; Lang, Dennis; Gottlieb, Michael; Houpt, Eric R; Platts-Mills, James A

    2016-11-01

     Enteropathogen infections have been associated with enteric dysfunction and impaired growth in children in low-resource settings. In a multisite birth cohort study (MAL-ED), we describe the epidemiology and impact of Campylobacter infection in the first 2 years of life.  Children were actively followed up until 24 months of age. Diarrheal and nondiarrheal stool samples were collected and tested by enzyme immunoassay for Campylobacter Stool and blood samples were assayed for markers of intestinal permeability and inflammation.  A total of 1892 children had 7601 diarrheal and 26 267 nondiarrheal stool samples tested for Campylobacter We describe a high prevalence of infection, with most children (n = 1606; 84.9%) having a Campylobacter-positive stool sample by 1 year of age. Factors associated with a reduced risk of Campylobacter detection included exclusive breastfeeding (risk ratio, 0.57; 95% confidence interval, .47-.67), treatment of drinking water (0.76; 0.70-0.83), access to an improved latrine (0.89; 0.82-0.97), and recent macrolide antibiotic use (0.68; 0.63-0.74). A high Campylobacter burden was associated with a lower length-for-age Z score at 24 months (-1.82; 95% confidence interval, -1.94 to -1.70) compared with a low burden (-1.49; -1.60 to -1.38). This association was robust to confounders and consistent across sites. Campylobacter infection was also associated with increased intestinal permeability and intestinal and systemic inflammation.  Campylobacter was prevalent across diverse settings and associated with growth shortfalls. Promotion of exclusive breastfeeding, drinking water treatment, improved latrines, and targeted antibiotic treatment may reduce the burden of Campylobacter infection and improve growth in children in these settings. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

  1. Dynamics and Trends in Fecal Biomarkers of Gut Function in Children from 1-24 Months in the MAL-ED Study.

    Science.gov (United States)

    McCormick, Benjamin J J; Lee, Gwenyth O; Seidman, Jessica C; Haque, Rashidul; Mondal, Dinesh; Quetz, Josiane; Lima, Aldo A M; Babji, Sudhir; Kang, Gagandeep; Shrestha, Sanjaya K; Mason, Carl J; Qureshi, Shahida; Bhutta, Zulfiqar A; Olortegui, Maribel Paredes; Yori, Pablo Peñataro; Samie, Amidou; Bessong, Pascal; Amour, Caroline; Mduma, Estomih; Patil, Crystal L; Guerrant, Richard L; Lang, Dennis R; Gottlieb, Michael; Caulfield, Laura E; Kosek, Margaret N

    2017-02-08

    Growth and development shortfalls that are disproportionately prevalent in children living in poor environmental conditions are postulated to result, at least in part, from abnormal gut function. Using data from The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) longitudinal cohort study, we examine biomarkers of gut inflammation and permeability in relation to environmental exposures and feeding practices. Trends in the concentrations of three biomarkers, myeloperoxidase (MPO), neopterin (NEO), and α-1-antitrypsin (AAT), are described from fecal samples collected during the first 2 years of each child's life. A total of 22,846 stool samples were processed during the longitudinal sampling of 2,076 children 0-24 months of age. Linear mixed models were constructed to examine the relationship between biomarker concentrations and recent food intake, symptoms of illness, concurrent enteropathogen infection, and socioeconomic status. Average concentrations of MPO, NEO, and AAT were considerably higher than published references for healthy adults. The concentration of each biomarker tended to decrease over the first 2 years of life and was highly variable between samples from each individual child. Both MPO and AAT were significantly elevated by recent breast milk intake. All three biomarkers were associated with pathogen presence, although the strength and direction varied by pathogen. The interpretation of biomarker concentrations is subject to the context of their collection. Herein, we identify that common factors (age, breast milk, and enteric infection) influence the concentration of these biomarkers. Within the context of low- and middle-income communities, we observe concentrations that indicate gut abnormalities, but more appropriate reference standards are needed. © The American Society of Tropical Medicine and Hygiene.

  2. Hydrogenation-disproportionation-desorption-recombination in Sm2Fe16M (M=Al, Ga and Si) and magnetic properties of their carburized powders

    International Nuclear Information System (INIS)

    Kubis, M.; Rave, W.; Cao, L.; Gebel, B.; Mueller, K.-H.; Schultz, L.

    1998-01-01

    The application of the hydrogenation-disproportionation-desorption-recombination (HDDR) process in Sm 2 Fe 16 M (M=Al,Ga and Si) was investigated. The hydrogen absorption behaviour was studied by temperature-pressure analysis (TPA). In the temperature range between 500 and 800 C, Sm 2 Fe 16 M samples with M=Ga and Si show a weaker hydrogen absorption than Sm 2 Fe 16 Al. This was confirmed by X-ray diffraction which showed a complete disproportionation of Sm 2 Fe 16 Al into SmH z (1.9 2 Fe 16 Ga and Sm 2 Fe 16 Si exhibit a fraction of undecomposed material with the Th 2 Zn 17 -type structure after the disproportionation procedure. These results point to a stabilization of Sm 2 Fe 16 M against disproportionation by hydrogen for M=Ga and Si. The magnetization processes of carburized HDDR powders were studied by VSM measurements and Kerr microscopy. The demagnetization curve of our HDDR processed Sm 2 Fe 16 AlC y is well shaped, whereas those of Sm 2 Fe 16 GaC y and Sm 2 Fe 16 SiC y show a large decrease of the polarization at low fields. The favourable behaviour of Sm 2 Fe 16 AlC y is due to a homogeneous submicron grain structure. In Sm 2 Fe 16 GaC y and Sm 2 Fe 16 SiC y samples, an additional, magnetically soft phase with larger domains was observed which causes the low coercivity. As a consequence, HDDR was only favourable for the preparation of Sm 2 Fe 16 MC y hard magnets with M=Al but not for M=Ga and Si. Optimization of the HDDR process in Sm 2 Fe 16 Al and subsequent nitrogenation or carburization led to coercivities of μ 0j H c =2.9 and 2.5 T, respectively. (orig.)

  3. Changes of serum NO/iNOS after whole abdominal irradiation in rats

    International Nuclear Information System (INIS)

    Lin Hong; Wu Wei; Zhang Kunhe; Chen Jiang; Wang Yang; Luo Hui; Huang Xiaoqing

    2004-01-01

    Objective: To observe the changes of serum NO/NOS concentrations in rats after whole abdominal irradiation and their relationships with intestinal radiation injury. Methods: Thirty health rats were randomly divided into three groups: normal control group, irradiation control group, and IgY protection group. The sera of rats were collected and the NO and iNOS were assayed. Results: NO and iNOS levels increased evidently in the irradiation control group in contrast with those of the normal control group (P<0.01). NO and iNOS levels increased slightly in the IgY protection group in contrast with the irradiation control group (P<0.01) and were close to the levels of the normal control group. The changes of NO and NOS concentrations were synchronous. Conclusion: NO and iNOS are good indices for detecting intestinal radiation injury. (authors)

  4. Circulating Blood eNOS Contributes to the Regulation of Systemic Blood Pressure and Nitrite Homeostasis

    Science.gov (United States)

    Wood, Katherine C.; Cortese-Krott, Miriam M.; Kovacic, Jason C.; Noguchi, Audrey; Liu, Virginia B.; Wang, Xunde; Raghavachari, Nalini; Boehm, Manfred; Kato, Gregory J.; Kelm, Malte; Gladwin, Mark T.

    2013-01-01

    Objective Mice genetically deficient in endothelial nitric oxide synthase (eNOS−/−) are hypertensive with lower circulating nitrite levels, indicating the importance of constitutively produced nitric oxide (NO•) to blood pressure regulation and vascular homeostasis. While the current paradigm holds that this bioactivity derives specifically from expression of eNOS in endothelium, circulating blood cells also express eNOS protein. A functional red cell eNOS that modulates vascular NO• signaling has been proposed. Approach and Results To test the hypothesis that blood cells contribute to mammalian blood pressure regulation via eNOS-dependent NO• generation, we cross-transplanted WT and eNOS−/− mice, producing chimeras competent or deficient for eNOS expression in circulating blood cells. Surprisingly, we observed a significant contribution of both endothelial and circulating blood cell eNOS to blood pressure and systemic nitrite levels, the latter being a major component of the circulating NO• reservoir. These effects were abolished by the NOS inhibitor L-NAME and repristinated by the NOS substrate L-Arginine, and were independent of platelet or leukocyte depletion. Mouse erythrocytes were also found to carry an eNOS protein and convert 14C-Arginine into 14C-Citrulline in a NOS-dependent fashion. Conclusions These are the first studies to definitively establish a role for a blood borne eNOS, using cross transplant chimera models, that contributes to the regulation of blood pressure and nitrite homeostasis. This work provides evidence suggesting that erythrocyte eNOS may mediate this effect. PMID:23702660

  5. Crime e castigo nos Estados Unidos: de Nixon a Clinton

    Directory of Open Access Journals (Sweden)

    Loïc Wacquant

    1999-11-01

    Full Text Available Este artigo analisa o crescimento exponencial do número de detentos ocorrido nos Estados Unidos a partir de meados dos anos 70. Procura mostrar que esse crescimento não corresponde a um aumento da criminalidade, mas à conjugação de três séries causais, quais sejam: o declínio do "ideal de reabilitação" dos prisioneiros, a instrumentalização do medo da violência pelos políticos e pela mídia e a função de mecanismo de controle racial assumido pelo sistema penal americano. Em suma, a hiperflação carcerária revela a contraface do enfraquecimento do Estado de Bem-Estar Social e a sua substituição por um Estado penal.

  6. A metodologia nos processos midiáticos

    OpenAIRE

    GOMES S. J, PEDRO GILBERTO

    2011-01-01

    Um grande desafio que temos hoje é a definiç ão e o estabelecimento do objeto da comunicaç ão. Este texto pretende discutir tanto a questão do objeto quando da metodologia nos processos mediáticos. Dizemos que o objeto precede ao método. Não podemos escolher um método se não se coñ éese o objeto. Para isso realiza um pequeno recorrido sobre o problema do método nas ciencias sociais e sua relaç ão com o objeto. A importância dessa discussão no âmbito da comunicaç ão está relacionada com o prob...

  7. Evaluation of an anti-p185{sup HER2} (scFv-C{sub H}2-C{sub H}3){sub 2} fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK

    Energy Technology Data Exchange (ETDEWEB)

    Vaidyanathan, Ganesan [Duke University Medical Center, Durham, NC 27710 (United States)], E-mail: ganesan.v@duke.edu; Jestin, Emmanuelle [Duke University Medical Center, Durham, NC 27710 (United States); Olafsen, Tove; Wu, Anna M. [Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095 (United States); Zalutsky, Michael R. [Duke University Medical Center, Durham, NC 27710 (United States)

    2009-08-15

    Introduction: A 105-kDa double mutant single-chain Fv-Fc fragment (scFv-Fc DM) derived from the anti-p185{sup HER2} hu4D5v8 antibody (trastuzumab; Herceptin) has been described recently. The goal of this study was to investigate whether improved tumor targeting could be achieved with this fragment through the use of residualizing radioiodination methods. Methods: The scFv-Fc DM fragment was radioiodinated using N-succinimidyl 4-guanidinomethyl 3-[{sup 131}I]iodobenzoate ([{sup 131}I]SGMIB) and N{sup {epsilon}}-(3-[{sup 131}I]iodobenzoyl)-Lys{sup 5}-N{sup {alpha}}- maleimido-Gly{sup 1}-GEEEK ([{sup 131}I]IB-Mal-D-GEEEK), two residualizing radioiodination agents that have been used successfully with intact antibodies. Paired-label internalization assays of the labeled fragments were performed in vitro using MCF7 human breast cancer cells transfected to express HER2 (MCF7-HER2); comparisons were made to scFv-Fc DM directly radioiodinated using Iodogen. The tissue distribution of the scFv-Fc DM labeled with [{sup 125}I]IB-Mal-D-GEEEK and [{sup 131}I]SGMIB was compared in athymic mice bearing MCF7-HER2 xenografts. Results: The scFv-Fc DM fragment was labeled with [{sup 131}I]SGMIB and [{sup 131}I]IB-Mal-D-GEEEK in conjugation yields of 53% and 25%, respectively, with preservation of immunoreactivity for HER2. Internalization assays indicated that labeling via SGMIB resulted in a 1.6- to 3.5-fold higher (P<.05) retention of radioactivity, compared to that from the directly labeled fragment, in HER2-expressing cells during a 24-h observation period. Likewise, the amount of radioactivity retained in cells from the IB-Mal-D-GEEEK-labeled fragment was 1.4- to 3.3-fold higher (P<.05). Tumor uptake of radioiodine activity in athymic mice bearing MCF7-HER2 xenografts in vivo was significantly higher for the [{sup 125}I]IB-Mal-D-GEEEK-labeled scFv-Fc DM fragment compared with that of the [{sup 131}I]SGMIB-labeled fragment, particularly at later time points. The uptake of {sup

  8. Malaria diagnosis and treatment under the strategy of the integrated management of childhood illness (IMCI): relevance of laboratory support from the rapid immunochromatographic tests of ICT Malaria P.f/P.v and OptiMal.

    Science.gov (United States)

    Tarimo, D S; Minjas, J N; Bygbjerg, I C

    2001-07-01

    The algorithm developed for the integrated management of childhood illness (IMCI) provides guidelines for the treatment of paediatric malaria. In areas where malaria is endemic, for example, the IMCI strategy may indicate that children who present with fever, a recent history of fever and/or pallor should receive antimalarial chemotherapy. In many holo-endemic areas, it is unclear whether laboratory tests to confirm that such signs are the result of malaria would be very relevant or useful. Children from a holo-endemic region of Tanzania were therefore checked for malarial parasites by microscopy and by using two rapid immunochromatographic tests (RIT) for the diagnosis of malaria (ICT Malaria P.f/P.v and OptiMal. At the time they were tested, each of these children had been targeted for antimalarial treatment (following the IMCI strategy) because of fever and/or pallor. Only 70% of the 395 children classified to receive antimalarial drugs by the IMCI algorithm had malarial parasitaemias (68.4% had Plasmodium falciparum trophozoites, 1.3% only P. falciparum gametocytes, 0.3% P. ovale and 0.3% P. malariae). As indicators of P. falciparum trophozoites in the peripheral blood, fever had a sensitivity of 93.0% and a specificity of 15.5% whereas pallor had a sensitivity of 72.2% and a specificity of 50.8%. The RIT both had very high corresponding sensitivities (of 100.0% for the ICT and 94.0% for OptiMal) but the specificity of the ICT (74.0%) was significantly lower than that for OptiMal (100.0%). Fever and pallor were significantly associated with the P. falciparum asexual parasitaemias that equalled or exceeded the threshold intensity (2000/microl) that has the optimum sensitivity and specificity for the definition of a malarial episode. Diagnostic likelihood ratios (DLR) showed that a positive result in the OptiMal test (DLR = infinity) was a better indication of malaria than a positive result in the ICT (DLR = 3.85). In fact, OptiMal had diagnostic reliability (0

  9. Unravelling Local Atomic Order of the Anionic Sublattice in M(Al1-x Gax )4 with M=Sr and Ba by Using NMR Spectroscopy and Quantum Mechanical Modelling.

    Science.gov (United States)

    Pecher, Oliver; Mausolf, Bernhard; Peters, Volker; Lamberts, Kevin; Korthaus, Alexander; Haarmann, Frank

    2016-12-05

    The quasibinary section of the intermetallic phases MAl 4 and MGa 4 with M=Sr and Ba have been characterised by means of X-ray diffraction (XRD) studies and differential thermal analysis. The binary phases show complete miscibility and form solid solutions M(Al 1-x Ga x ) 4 with M=Sr and Ba. These structures crystallise in the BaAl 4 structure type with four- and five-bonded Al and/or Ga atoms (denoted as Al(4b), Al(5b), Ga(4b), and Ga(5b), respectively) that form a polyanionic Al/Ga sublattice. Solid state 27 Al NMR spectroscopic analysis and quantum mechanical (QM) calculations were applied to study the bonding of the Al centres and the influence of Al/Ga substitution, especially in the regimes with low degrees of substitution. M(Al 1-x Ga x ) 4 with M=Sr and Ba and 0.925≤x≤0.975 can be described as a matrix of the binary majority compound in which a low amount of the Ga atoms has been substituted by Al atoms. In good agreement with the QM calculations, 27 Al NMR investigations and single crystal XRD studies prove a preferred occupancy of Al(4b) for these substitution regimes. Furthermore, two different local Al environments were found, namely isolated Al(4b1) atoms and Al(4b2), due to the formation of Al(4b)-Al(4b) pairs besides isolated Al(4b) atoms within the polyanionic sublattice. QM calculations of the electric field gradient (EFG) using superlattice structures under periodic boundary conditions are in good agreement with the NMR spectroscopic results. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. O mal-estar na modernidade e a psicanálise: a psicanálise à prova do social The discontent in modernity and psychoanalysis: social-proof psychoanalysis

    Directory of Open Access Journals (Sweden)

    Joel Birman

    2005-01-01

    Full Text Available O artigo tem a intenção de indicar a presença de dois discursos teóricos opostos em Freud, no que concerne às relações entre sujeito e modernidade. Pretende-se demonstrar que na sua segunda versão, desenvolvida em Mal-estar na civilização, o discurso psicanalítico realizou uma crítica sistemática de sua versão inicial, esboçada em "Moral sexual 'civilizada' e a doença nervosa dos tempos modernos". Pela construção dos conceitos de desamparo e de mal-estar, o discurso freudiano colocou então a psicanálise à prova do social. Além disso, indica que aquela pôde construir uma leitura sobre a modernidade, ao lado das que foram realizadas por Weber e Heidegger. Finalmente, esse percurso tem ainda a finalidade de pensar a crise da psicanálise na atualidade, nas novas condições do mal-estar na modernidade.The article aims at showing the presence of two opposing theoretical discourses in Freud, in what concerns the relationship between the subject and modemity. It intends to demonstrate that in its second version, developed in Malaise dansia civilisation, the analytical discourse achieved a systematic critical review of its initial version outlined in "La morale sexuelle 'civilisée' et la maladie nerveuse des temps modemes". Through constructing the concepts of discontent and distress, the Freudian discourse thus made psychoanalysis social-proof. ln addition, it indicates that psychoanalysis was able to build a reading of modemity other than those made by Weber and Heidegger. Finally, this joumey also aims at thinking over the present crisis of psychoanalysis within the new conditions of discontent in modemity.

  11. Technical Specifications, Braidwood Station, Unit Nos. 1 and 2 (Docket Nos. STN 50-456 and STN 50-457). Appendix ''A'' to License No. NPF-59

    International Nuclear Information System (INIS)

    1986-10-01

    Information is presented for Braidwood Station Unit Nos. 1 and 2 in the areas of: safety limits and limiting safety system settings; limiting conditions for operation and surveillance requirements; design features; and administrative controls

  12. “El florecimiento del terrorismo islámico en el Sahel, un reto para la seguridad de Europa Occidental. Estudio de caso: Malí y España (2011- 2013)”

    OpenAIRE

    Rodríguez Uribe, Mónica Alejandra

    2015-01-01

    El objetivo central de este Estudio de Caso, consiste en investigar en qué sentido la proximidad geográfica y el hecho de que la región del Sahel constituya una zona de tránsito, influyen a que el crecimiento del terrorismo islámico en Malí comprenda una amenaza tanto para la seguridad nacional, como para la estabilidad de España. Se avanzará posteriormente con la descripción de herramientas específicas, tanto judiciales como de cooperación que el gobierno español ha buscado apoyar a nivel ...

  13. Luminescent phosphors, based on rare earth substituted oxyfluorides in the A(1)3-x A(2)xMO4F family with A(1)/A(2)=Sr, Ca, Ba and M=Al, Ga

    International Nuclear Information System (INIS)

    Park, Sangmoon; Vogt, Thomas

    2009-01-01

    A new family of UV-activated phosphors made by substituting rare-earth activators such as trivalent Eu, Tb, Tm and Er into A(1) 3-x A(2) x MO 4 F host lattices (A(1)/A(2)=Sr, Ca, Ba; M=Al, Ga) are introduced and their activation and emission spectra as well as their CIE values reported. The Tm-substituted system can be activated using light with a wavelength of 360 nm. Relative intensities of a family of Tb-substituted green phosphors activated at 254 nm and with emissions centered near 548 nm are discussed.

  14. Luminescent phosphors, based on rare earth substituted oxyfluorides in the A(1){sub 3-x} A(2){sub x}MO{sub 4}F family with A(1)/A(2)=Sr, Ca, Ba and M=Al, Ga

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sangmoon, E-mail: spark@silla.ac.k [Department of Engineering in Energy and Applied Chemistry, Silla University, Busan 617-736 (Korea, Republic of); Vogt, Thomas [NanoCenter and Department of Chemistry and Biochemistry, University of South Carolina, Columbia 29208, SC (United States)

    2009-09-15

    A new family of UV-activated phosphors made by substituting rare-earth activators such as trivalent Eu, Tb, Tm and Er into A(1){sub 3-x}A(2){sub x}MO{sub 4}F host lattices (A(1)/A(2)=Sr, Ca, Ba; M=Al, Ga) are introduced and their activation and emission spectra as well as their CIE values reported. The Tm-substituted system can be activated using light with a wavelength of 360 nm. Relative intensities of a family of Tb-substituted green phosphors activated at 254 nm and with emissions centered near 548 nm are discussed.

  15. Estudio descriptivo de mal oclusiones y opciones de tratamiento en estudiantes de segundo y tercer semestre de la Universidad de las Américas del Distrito Metropolitano de Quito, período Octubre 2013 – Enero 2014

    OpenAIRE

    Santacruz Escobar, Paul Santiago

    2014-01-01

    Las mal oclusiones dentales son patologías frecuentes en la cavidad bucal a nivel mundial, debido a que esta enfermedad es multifactorial además de verse afectada por otros procesos patológicos, surge la importancia decisiva de tomar medidas de salud pública para contrarrestar las secuelas de dicha enfermedad, así como su pronta prevención. El presente estudio es de carácter descriptivo, transversal, en el cual fueron examinados 268 estudiantes entre diecisiete y veinte y cinco años de edad, ...

  16. La miseria de la literatura: el mal en las representaciones de los escritores de La literatura nazi en América, Estrella distante y la no ficción de Roberto Bolaño

    OpenAIRE

    Villacreses Benavides, Norman Xavier

    2016-01-01

    La obra y la figura como escritor de Roberto Bolaño es uno de los espacios de investigación de los estudios literarios más importantes en la actualidad. Esto se debe tanto a la repercusión de su ficción dentro de la narrativa hispanoamericana contemporánea como a sus posiciones frente al ejercicio de la literatura. Esta investigación se ha propuesto hallar de qué forma se generan las representaciones del mal dentro del universo literario de Bolaño y cuál es su funcionamiento, tomando como ele...

  17. A teoria da pessoa de Tim Ingold: mudança ou continuidade nas representações ocidentais e nos conceitos antropológicos?

    Directory of Open Access Journals (Sweden)

    Regina Coeli Machado e Silva

    2011-06-01

    Full Text Available O objetivo deste artigo é discutir a proposta analítica de Tim Ingold para compreender a noção de pessoa, que pretende superar a dualidade mente/corpo. Essa dualidade é "repensada" através da objeção ao conceito de "representação coletiva", em favor de uma abordagem que incorpora elementos biológicos na explicação, concebendo a noção de pessoa como um aspecto da vida orgânica. O argumento aqui desenvolvido é que a incorporação desses princípios como uma tentativa de superar o dualismo mente/corpo nos obriga a enfrentar de modo renovado as questões aí colocadas, mas questiona se o resultado não seria reiterar explicações das propostas analíticas que quer refutar. Isto é, a base epistemológica da escola sociológica francesa que postula o fundamento social da cognição. Para isso, este artigo está organizado em três partes. A primeira, introdutória, apresenta o contexto social recente e o desenvolvimento das ciências cognitivas como condições propiciadoras da retomada do tema em questão. A segunda apresenta a perspectiva analítica de Ingold para compreender a noção de pessoa que, ao mesmo tempo, pretende ultrapassar dualismos como natureza e cultura, mente e corpo. Finalmente, na terceira parte, discute as implicações teóricas e ideológicas do argumento analítico proposto por IngoldThe aim of this paper is to discuss the analytical proposition of Tim Ingold in understanding the notion of Person who wants to overcome the duality of mind and body. This duality is "rethought" through the objection to the concept of "collective representation", in favor of an approach that incorporates biological principles in explaining, to conceive the person as an aspect of organic life in general. The argument developed here is that the incorporation of these principles as an attempt to overcome the mind / body dualism forces us to confront the issues in a new way. And it also questions whether the result would not renew

  18. Crataegus Special Extract WS 1442 Effects on eNOS and microRNA 155.

    Science.gov (United States)

    Wang, Xinwen; Liang, Yan; Shi, Jian; Zhu, Hao-Jie; Bleske, Barry E

    2018-04-16

    Increased expression of microRNA 155 (miR-155) results in a decrease in endothelial nitric oxide synthase (eNOS) expression and impaired endothelial function. Factors that have been shown to increase expression of miR-155 may be mitigated by WS 1442, an extract of hawthorn leaves and flowers ( Crataegus special extract) that contains a range of pharmacologically active substances including oligomeric proanthocyanidins and flavonoids. The purpose of this study is to determine the effect of WS 1442 on the expression of miR-155 and eNOS in the presence of tumor necrosis factor (TNF- α ). Human umbilical vein endothelial cells (HUVECs) were studied after the exposure to TNF- α , with or without simvastatin (positive control) and WS 1442. The expression levels of eNOS, phosphorylated eNOS, and miR-155 in the different HUVEC treatment groups were determined by western blot and quantitative real-time polymerase chain reaction, respectively. To evaluate the effect of WS 1442 on the eNOS activity, the medium and intracellular nitrate/nitrite (NO) concentrations were also analyzed using a colorimetric Griess assay kit. The results demonstrated that TNF- α upregulated miR-155 expression and decreased eNOS expression and NO concentrations. WS 1442 also increased miR-155 expression and decreased eNOS expression but, unlike TNF- α , increased phosphorylated eNOS expression and NO concentrations. Surprisingly, WS 1442 increased miR-155 expression; however, WS 1442 mitigated the overall negative effect of miR-155 on decreasing eNOS expression by increasing expression of phosphorylated eNOS and resulting in an increase in NO concentrations. In the setting where miR-155 may be expressed, WS 1442 may offer vascular protection by increasing the expression of phosphorylated eNOS. Georg Thieme Verlag KG Stuttgart · New York.

  19. Expression of beta-catenin, COX-2 and iNOS in colorectal cancer: relevance of COX-2 adn iNOS inhibitors for treatment in Malaysia.

    Science.gov (United States)

    Hong, Seok Kwan; Gul, Yunus A; Ithnin, Hairuszah; Talib, Arni; Seow, Heng Fong

    2004-01-01

    Promising new pharmacological agents and gene therapy targeting cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) could modulate treatment of colorectal cancer in the future. The aim of this study was to elucidate the expression fo beta-catenin and teh presence of COX-2 and iNOS in colorectal cancer specimens in Malaysia. This is a useful prelude to future studies investigating interventions directed towards COX-2 adn iNOS. A cross-section study using retrospective data over a 2-year period (1999-2000) involved 101 archival, formalin-fixed, paraffin-embedded tissue samples of colorectal cancers that were surgically resected in a tertiary referral. COX-2 production was detected in adjacent normal tissue in 34 sample (33.7%) and in tumour tissue in 60 samples (59.4%). More tumours expressed iNOS (82/101, 81.2%) than COX-2. No iNOS expression was detected in adjacent normal tissue. Intense beta-catenin immunoreactivity at the cell-to-cell border. Poorly differentiated tumours had significantly lower total beta-catenin (p = 0.009) and COX-2 scores (p = 0.031). No significant relationships were established between pathological stage and beta-catenin, COX-2 and iNOS scores. the accumulation of beta-catenin does not seem to be sufficient to activate pathways that lead to increased COX-2 and iNOS expression. A high proportion of colorectal cancers were found to express COX-2 and a significant number produced iNOS, suggesting that their inhibitors may be potentially useful as chemotherapeutic agents in the management of colorectal cancer.

  20. Asiatic Acid Alleviates Hemodynamic and Metabolic Alterations via Restoring eNOS/iNOS Expression, Oxidative Stress, and Inflammation in Diet-Induced Metabolic Syndrome Rats

    Directory of Open Access Journals (Sweden)

    Poungrat Pakdeechote

    2014-01-01

    Full Text Available Asiatic acid is a triterpenoid isolated from Centella asiatica. The present study aimed to investigate whether asiatic acid could lessen the metabolic, cardiovascular complications in rats with metabolic syndrome (MS induced by a high-carbohydrate, high-fat (HCHF diet. Male Sprague-Dawley rats were fed with HCHF diet with 15% fructose in drinking water for 12 weeks to induce MS. MS rats were treated with asiatic acid (10 or 20 mg/kg/day or vehicle for a further three weeks. MS rats had an impairment of oral glucose tolerance, increases in fasting blood glucose, serum insulin, total cholesterol, triglycerides, mean arterial blood pressure, heart rate, and hindlimb vascular resistance; these were related to the augmentation of vascular superoxide anion production, plasma malondialdehyde and tumor necrosis factor-alpha (TNF-α levels (p < 0.05. Plasma nitrate and nitrite (NOx were markedly high with upregulation of inducible nitric oxide synthase (iNOS expression, but dowregulation of endothelial nitric oxide synthase (eNOS expression (p < 0.05. Asiatic acid significantly improved insulin sensitivity, lipid profiles, hemodynamic parameters, oxidative stress markers, plasma TNF-α, NOx, and recovered abnormality of eNOS/iNOS expressions in MS rats (p < 0.05. In conclusion, asiatic acid improved metabolic, hemodynamic abnormalities in MS rats that could be associated with its antioxidant, anti-inflammatory effects and recovering regulation of eNOS/iNOS expression.

  1. Expression profiles of eNOS, iNOS and microRNA-27b in the corpus cavernosum of rats submitted to chronic alcoholism and Diabetes mellitus.

    Science.gov (United States)

    Cunha, Joao Paulo da; Lizarte, Fermino Sanches; Novais, Paulo Cezar; Gattas, Daniela; Carvalho, Camila Albuquerque Mello de; Tirapelli, Daniela Pretti da Cunha; Molina, Carlos Augusto Fernandes; Tirapelli, Luis Fernando; Tucci, Silvio

    2017-01-01

    To evaluate the expression of endothelial and inducible NOS in addition to the miRNA-27b in the corpus cavernosum and peripheral blood of healthy rats, diabetic rats, alcoholic rats and rats with both pathologies. Forty eight Wistar rats were divided into four groups: control (C), alcoholic (A), diabetic (D) and alcoholic-diabetic (AD). Samples of the corpus cavernosum were prepared to study protein expressions of eNOS and iNOS by immunohistochemistry and expression of miRNA-27b in the corpus cavernosum and peripheral blood. Immunohistochemistry for eNOS and iNOS showed an increase in cavernosal smooth muscle cells in the alcoholic, diabetic and alcoholic-diabetic groups when compared with the control group. Similarly, the mRNA levels for eNOS were increased in cavernosal smooth muscle (CSM) in the alcoholic, diabetic and alcoholic-diabetic groups and miRNA-27b were decreased in CSM in the alcoholic, diabetic and alcoholic-diabetic groups. The major new finding of our study was an impairment of relaxation of cavernosal smooth muscle in alcoholic, diabetic, and alcoholic-diabetic rats that involved a decrease in the nitric oxide pathway by endothelium-dependent mechanisms accompanied by a change in the corpus cavernosum contractile sensitivity.

  2. Un cinéma palestinien « en mal d’archive » The “Archive Fever” of Palestinian Cinema

    Directory of Open Access Journals (Sweden)

    Laure Fourest

    2012-05-01

    Full Text Available À partir de l’analyse de trois films palestiniens réalisés dans les années 2000, cet article propose d’interroger l’insertion d’images d’archives par les cinéastes dans leur montage : quelles stratégies mettent-ils en œuvre et à quelles fins ? Qu’apportent des images d’archives en plus des témoignages filmés ? Comment le recours à ces images permet-il de participer au débat historiographique qui sous-tend et détermine en partie le conflit israélo-palestinien ? Dans le contexte palestinien où il n’existe pas d’institution archivistique officielle, les archives sont porteuses d’enjeux particulièrement saillants, donnant lieu à un véritable « mal d’archive ». Celui-ci fait naître une multiplicité de stratégies cinématographiques visant à questionner cette zone d’inconfort, où le maniement des qualités émotionnelles et sensorielles de l’archive peut être un moyen de faire preuve.Through the analysis of three Palestinian films created in the 2000-2010 period, this article considers filmmakers’ insertion of archival images in their montages: what strategies do they employ and for what purpose? What do archival images add to filmed testimony? How does the use of these images enable participation in the historiographical debate underlying and partly determining the Israel-Palestine conflict? In the Palestinian context, where no official archive institution exists, archives entail particularly salient issues, making their lack truly sore. This generates a multiplicity of cinematographic strategies aiming to challenge this discomfort zone, where the manipulation of the emotional and sensorial qualities of archives can be a means of proving something.

  3. Hydrogenation-disproportionation-desorption-recombination in Sm{sub 2}Fe{sub 16}M (M=Al, Ga and Si) and magnetic properties of their carburized powders

    Energy Technology Data Exchange (ETDEWEB)

    Kubis, M.; Rave, W.; Cao, L.; Gebel, B.; Mueller, K.-H.; Schultz, L. [Institut fuer Festkoerper- und Werkstofforschung Dresden e.V. (Germany)

    1998-11-20

    The application of the hydrogenation-disproportionation-desorption-recombination (HDDR) process in Sm{sub 2}Fe{sub 16}M (M=Al,Ga and Si) was investigated. The hydrogen absorption behaviour was studied by temperature-pressure analysis (TPA). In the temperature range between 500 and 800 C, Sm{sub 2}Fe{sub 16}M samples with M=Ga and Si show a weaker hydrogen absorption than Sm{sub 2}Fe{sub 16}Al. This was confirmed by X-ray diffraction which showed a complete disproportionation of Sm{sub 2}Fe{sub 16}Al into SmH{sub z} (1.9M=Al but not for M=Ga and Si. Optimization of the HDDR process in Sm{sub 2}Fe{sub 16}Al and subsequent nitrogenation or carburization led to coercivities of {mu}{sub 0j}H{sub c}=2.9 and 2.5 T, respectively. (orig.) 11 refs.

  4. Faktoring – jedna z hlavních forem financování malých a středních podniků

    Directory of Open Access Journals (Sweden)

    Müllerová Libuše

    2009-12-01

    Full Text Available Faktoring představuje službu, kterou poskytují specializované faktoringové společnosti svým klientům v souvislosti s postoupením nebo se správou pohledávek. Ve své podstatě se jedná o určitý způsob úvěrování, využívaný zejména malými a středními podniky. V praxi existuje několik forem faktoringu v závislosti na tom, do jaké míry přechází na faktora vlastnictví pohledávek a rizika jejich nesplacení. Podle toho se pak faktoringové transakce promítají do účetnictví faktora i klienta. Vzhledem k tomu, že tato služba ani její formy není upravená žádným právním předpisem, postupují faktoringové společnosti často tak, že podmínky ve smlouvách – z důvodu daňových – často zakrývají svojí formou skutečný stav. Uvedený příspěvek základní formy faktoringu vymezuje, popisuje jejich správné účtování včetně daňových dopadů. Factoring is a service, which is offered by specialized factoring agencies to their clients in case of transfer (sale or governance of receivables. In fact, it represents a specific mode of crediting which is mostly preferred by small and medium enterprises. In practices of factoring several forms are differentiated depending on scale of property and risk transfer to the factor. According to these circumstances the factoring transactions are recognized by the factor and the client. The factoring services are not so far regulated by any legal provision. For this reason factoring agencies are proceeding in such a way, that contract conditions – because of tax considerations – hide by their form the substance. The paper describes the factoring forms and interprets their correct recognition on accounting, including tax consequences.

  5. FACTORES ASOCIADOS A MAL ESTADO DE SALUD PERCIBIDO O A MALA CALIDAD DE VIDA EN PERSONAS MAYORES DE 65 AÑOS

    Directory of Open Access Journals (Sweden)

    Mercedes Azpiazu Garrido

    2002-01-01

    Full Text Available Fundamento: Hoy en d a, en los pa ses desarrollados, llegar a una edad avanzada ha dejado de ser algo excepcional, sin embargo muchas personas no logran envejecer con una buena calidad de vida. El presente trabajo tiene como objetivos, contribuir a un mejor conocimiento de los principales factores que influyen en la calidad de vida y la percepci n de la salud de los mayores de 65 a os, as como determinar qu ventajas y desventajas presenta cada uno de los tres instrumentos de medida de la salud y la calidad de vida frente a los otros dos instrumentos utilizados. M todos: A partir de 911 encuestas a personas mayores de 65 a os no institucionalizadas, realizadas a domicilio, se hizo un an lisis multivariante mediante regresi n log stica, poniendo en relaci n los resultados obtenidos en el Perfil de Salud de Nottingham (PSN, el Euroqol y el EAS con las caracter siticas sociodemogr ficas, el nivel de recursos econ micos, el grado de apoyo sociofamiliar, el estado de salud f sica y mental y la capacidad funcional. Resultados: Los principales factores que se asocian con la percepci n de un mal estado de salud y mala calidad de vida en el Euroqol y el PSN son los trastornos de ansiedad (Odd Ratios entre 1,8 (IC:1,2-2,8 para movilidad y 7,9 (IC:4,5-13,9 para Perfil 11111, trastornos depresivos (OR:1,8 (IC:1,3-2,6 para dolor/malestar ?3,3 (IC:2,1-5,1 para aislamiento social, falta de ejercicio (OR:1,4 (IC:1-2,1 para ansiedad/depresi n ?3,9 (IC:2,5-6,2 para actividades cotidianas, dependencia para las actividades b sicas de la vida diaria (OR:0,5 (IC:0,3-0,9 para reacci n emocional ?4,8 (IC:3-7,6 para actividades cotidianas y dependencia para las actividades instrumentales de la vida diaria (OR:1,5 (IC:1,1-2,1 para Escala Visual Anal gicac < 70 ? 7,1 (IC:2,9-17,2 para cuidado personal. Conclusiones: La salud mental y la capacidad funcional son los factores que m s influyen en la percepci n del estado de salud y la calidad de vida de las personas mayores

  6. NOS3 Variants, Physical Activity, and Blood Pressure in the European Youth Heart Study

    DEFF Research Database (Denmark)

    Grøntved, Anders; Andersen, Lars Bo; Franks, Paul W

    2011-01-01

    BackgroundIn this study, we examined the influence of genetic variation in NOS3 on resting blood pressure (BP) in children and adolescents from the European Youth Heart Study (EYHS). Because the NOS3 gene expression is altered by physical activity (PA), we also tested for interaction between...

  7. Suggesting a NOS Map for Nature of Science for Science Education Instruction

    Science.gov (United States)

    Oh, Jun-Young

    2017-01-01

    The aims of this research are 1) to explore the inter-relationships within the individual elements or tenets of Nature of Science (NOS), based on the dimensions of scientific knowledge in science learning, and 2) to consider Kuhn's concept of how scientific revolution takes place. This study suggests that instruction according to our NOS Flowchart…

  8. Association between nucleotide mutation of eNOS gene and serum ...

    African Journals Online (AJOL)

    Various mutation on endothelial nitric oxide synthase (eNOs) gene cause reduced production of NO, the expansion factor (VEF) and may accelerate the process of atherosclerosis. The study was designed to investigate the frequency of T-786C polymorphism of the gene or nucleotide mutation of eNOS gene in patients ...

  9. Complex posttraumatic stress disorder: an exploratory investigation of PTSD and DES NOS among Dutch war veterans

    NARCIS (Netherlands)

    Jongedijk, R. A.; Carlier, I. V.; Schreuder, B. J.; Gersons, B. P.

    1996-01-01

    The recently developed concept Disorder of Extreme Stress Not Otherwise Specified (DES NOS) or complex posttraumatic stress disorder (complex PTSD) is designed to encompass long-standing symptoms not present in PTSD. An exploratory investigation of PTSD and DES NOS was performed with the Structured

  10. Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em recém-nascidos de grávidas com malária, na Colômbia Intrauterine growth retardation, low birth weight and prematurity in neonates of pregnant women with malaria in Colombia

    OpenAIRE

    Alberto Tobón-Castaño; Martha Arismendi Solano; Luis Gonzalo Álvarez Sánchez; Silvia Blair Trujillo

    2011-01-01

    INTRODUÇÃO: É frequente a associação da malária com complicações como prematuridade, retardo no crescimento intrauterino, baixo peso ao nascer e mortalidade infantil, efeitos pouco estudados em áreas hipoendêmicas para malaria. O objetivo deste estudo foi analisar a relação da malária gestacional com estes efeitos em recém-nascidosnuma região endêmica para malária na Colômbia, entre 1993 e 2007. MÉTODOS: Foram estudadas as características em 1.716 recém-nascidos num estudo de coorte. Fez-se s...

  11. Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus

    DEFF Research Database (Denmark)

    Harvey, Brian H; Oosthuizen, Frasia; Brand, Linda

    2004-01-01

    . The NOS isoform involved, and the role of stress-mediated corticosterone release in NOS activation, was verified with the administration of selective iNOS and nNOS inhibitors, aminoguanidine (50 mg/kg/day i.p.) and 7-nitroindazole (12.5 mg/kg/day i.p.), and the steroid synthesis inhibitor, ketoconazole...... (24 mg/kg/day i.p.), administered for 21 days prior to and during the stress procedure. RESULTS: Stress evoked a sustained increase in NOS activity, but reduced NMDA receptor density and total GABA levels. Aminoguanidine or ketoconazole, but not 7-nitroindazole or saline, blocked stress-induced NOS...

  12. Obesity, inflammation, and exercise training: relative contribution of iNOS and eNOS in the modulation of vascular function in the mouse aorta

    Directory of Open Access Journals (Sweden)

    Josiane Fernandes da Silva

    2016-09-01

    Full Text Available Background - The understanding of obsesity-related vascular dysfunction remains controversial mainly because of the diseases associated with vascular injury. Exercise training is known to prevent vascular dysfunction. Using an obesity model without comorbidities, we aimed at investigating the underlying mechanism of vascular dysfunction and how exercise interferes with this process.Methods - High-sugar diet was used to induce obesity in mice. Exercise training was performed 5 days/week. Body weight, energy intake, and adipose tissues were assessed; blood metabolic and hormonal parameters were determined; and serum TNFα was measured. Blood pressure and heart rate were assessed by plethysmography. Changes in aortic isometric tension were recorded on myograph. Western blot was used to analyze protein expression. Nitric oxide (NO was evaluated using fluorescence microscopy. Antisense oligodeoxynucleotides were used for inducible nitric oxide synthase isoform (iNOS knockdown.Results - Body weight, fat mass, total cholesterol, low-density lipoprotein cholesterol fraction, insulin, and leptin were higher in the sedentary obese group (SD than in the sedentary control animals (SS. Exercise training prevented these changes. No difference in glucose tolerance, insulin sensitivity, blood pressure, and heart rate was found. Decreased vascular relaxation and reduced endothelial nitric oxide synthase (eNOS functioning in the SD group were prevented by exercise. Contractile response to phenylephrine was decreased in the aortas of the wild SD mice, compared with that of the SS group; however, no alteration was noted in the SD iNOS-/- animals. The decreased contractility was endothelium-dependent, and was reverted by iNOS inhibition or iNOS silencing. The aortas from the SD group showed increased basal NO production, serum TNFα, TNF receptor-1, and phospho-IκB. Exercise training attenuated iNOS-dependent reduction in contractile response in high-sugar diet

  13. Epidemiological and ecological aspects related to malaria in the area of influence of the lake at Porto Primavera dam, in western São Paulo State, Brazil Aspectos epidemiológicos e ecológicos relacionados à malária na área de influência do lago da Represa de Porto Primavera, região oeste do Estado de São Paulo, Brasil

    Directory of Open Access Journals (Sweden)

    Almério de C. Gomes

    2008-10-01

    this paper.Foi realizada pesquisa na área de influência do lago da Usina Hidrelétrica de Porto Primavera, região oeste do Estado de São Paulo, para estudar aspectos ecológicos e epidemiológicos da malária na localidade e acompanhar o perfil das populações de anofelinos frente às mudanças decorrentes do impacto ambiental pela formação do lago. Mosquitos capturados foram analisados pelo Índice de Abundância de Espécies Padronizado (IAEP, antes e durante o enchimento do reservatório (cotas 253 e 257 m. A população humana local foi estudada por meio de teste parasitológico (gota espessa e esfregaço sangüíneo, testes moleculares (PCR e testes sorológicos. A sorologia consistiu na reação de ELISA com peptídeos sintéticos correspondentes à porção repetitiva da proteína circumsporozoíta (CSP de Plasmodium vivax clássico, e suas variantes VK247 e "vivax-like", P. malariae e P. falciparum; e reação de Imunofluorescência Indireta (RIFI com formas assexuadas de P. vivax, P. malariae e P. falciparum. Os resultados do estudo entomológico indicaram que, embora a população de Anopheles darlingi tenha aumentando após o enchimento, permaneceu em baixa densidade. Não foi detectada malária nem a presença de parasitos ou de DNA parasitário nos habitantes estudados. No entanto, foi observada baixa freqüência de anticorpos contra formas assexuadas e significativa prevalência de anticorpos contra esporozoítos de P. vivax e suas variantes, P. falciparum e P. malariae, que poderiam decorrer de contatos prévios, recentes ou não, com plasmódios humanos ou símios (o ciclo silvestre foi evidenciado em estudo paralelo realizado na mesma área. Por outro lado, estes resultados sugerem que, como em outros lugares onde existem vetores potenciais da malária, as condições epidemiológicas poderiam potencialmente permitir a transmissão da malária na área de influência do lago de Porto Primavera, se indivíduos infectados fossem introduzidos em n

  14. Phenotyping of nNOS neurons in the postnatal and adult female mouse hypothalamus.

    Science.gov (United States)

    Chachlaki, Konstantina; Malone, Samuel A; Qualls-Creekmore, Emily; Hrabovszky, Erik; Münzberg, Heike; Giacobini, Paolo; Ango, Fabrice; Prevot, Vincent

    2017-10-15

    Neurons expressing nitric oxide (NO) synthase (nNOS) and thus capable of synthesizing NO play major roles in many aspects of brain function. While the heterogeneity of nNOS-expressing neurons has been studied in various brain regions, their phenotype in the hypothalamus remains largely unknown. Here we examined the distribution of cells expressing nNOS in the postnatal and adult female mouse hypothalamus using immunohistochemistry. In both adults and neonates, nNOS was largely restricted to regions of the hypothalamus involved in the control of bodily functions, such as energy balance and reproduction. Labeled cells were found in the paraventricular, ventromedial, and dorsomedial nuclei as well as in the lateral area of the hypothalamus. Intriguingly, nNOS was seen only after the second week of life in the arcuate nucleus of the hypothalamus (ARH). The most dense and heavily labeled population of cells was found in the organum vasculosum laminae terminalis (OV) and the median preoptic nucleus (MEPO), where most of the somata of the neuroendocrine neurons releasing GnRH and controlling reproduction are located. A great proportion of nNOS-immunoreactive neurons in the OV/MEPO and ARH were seen to express estrogen receptor (ER) α. Notably, almost all ERα-immunoreactive cells of the OV/MEPO also expressed nNOS. Moreover, the use of EYFP Vglut2 , EYFP Vgat , and GFP Gad67 transgenic mouse lines revealed that, like GnRH neurons, most hypothalamic nNOS neurons have a glutamatergic phenotype, except for nNOS neurons of the ARH, which are GABAergic. Altogether, these observations are consistent with the proposed role of nNOS neurons in physiological processes. © 2017 Wiley Periodicals, Inc.

  15. Malária durante a gravidez: efeito sobre o curso da gestação na região amazônica Impact of malaria during pregnancy in the Amazon region

    Directory of Open Access Journals (Sweden)

    Eda Cristina da Silva Chagas

    2009-09-01

    Full Text Available OBJETIVO: Estimar o efeito da malária sobre o curso da gestação em mulheres na região amazônica e investigar possíveis fatores de risco nessa população. MÉTODOS: Este estudo transversal é parte de um projeto maior para estudar malária e gravidez na região amazônica. Foram incluídas gestantes com malária atendidas na Fundação de Medicina Tropical do Amazonas que responderam a entrevistas estruturadas. Dados socio-econômicos, comportamentais e clínicos foram levantados na primeira consulta relacionada a cada novo episódio de malária na gestante. Todas as gestantes foram acompanhadas ao longo de sua gestação. Foram considerados os seguintes fatores de risco para alterações no curso da gestação: idade materna menor do que 20 anos, primeira gestação, primeira infecção malárica e espécie de plasmódio infectante. RESULTADOS: Foram avaliados 535 episódios de malária em 417 gestantes, sendo 20,56% causados pelo P. falciparum, 78,69% pelo P. vivax e 0,75% pela associação dos dois parasitas. Alteração no curso da gestação foi um evento muito frequente (26,2%. Ameaça de aborto ocorreu em 49 casos (25,5%, aborto em dois (1,0%, ameaça de parto prematuro em 74 (25,1% e parto prematuro em três (1,0%. Ser primigesta e adolescente apresentou associação estatisticamente significativa com ameaça de parto prematuro e abortamento. CONCLUSÃO: A alteração no curso da gestação foi um evento muito frequente durante o episódio agudo de malária, embora a interrupção da gestação tenha tido baixa ocorrência em nossa casuística. Os resultados não evidenciaram um fator de risco de destaque, sugerindo que qualquer gestante pode apresentar ameaça de interrupção ou interrupção da gestação na vigência de episódio agudo de malária.OBJECTIVE: To estimate the impact of malaria on the course of pregnancy in women from the Amazon region and to investigate possible risk factors in this population. METHODS: This

  16. Structure, microstructure and determination of optical constants from transmittance data of co-doped Zn0.90Co0.05M0.05O (M=Al, Cu, Cd, Na) films

    International Nuclear Information System (INIS)

    2 A Laboratoire des Structures, Propriétés et Interactions Inter Atomiques, Université Abbes Laghrour, Khenchela 40000 (Algeria))" data-affiliation=" (LASPI2 A Laboratoire des Structures, Propriétés et Interactions Inter Atomiques, Université Abbes Laghrour, Khenchela 40000 (Algeria))" >Roguai, S.; 2 A Laboratoire des Structures, Propriétés et Interactions Inter Atomiques, Université Abbes Laghrour, Khenchela 40000 (Algeria))" data-affiliation=" (LASPI2 A Laboratoire des Structures, Propriétés et Interactions Inter Atomiques, Université Abbes Laghrour, Khenchela 40000 (Algeria))" >Djelloul, A.; Nouveau, Corinne; Souier, T.; Dakhel, A.A.; Bououdina, M.

    2014-01-01

    Highlights: • A series of Zn 0.90 Co 0.05 M 0.05 O (M=Al, Cu, Cd, Na) films has been prepared. • Thin films of these prepared samples have been deposited using USP technique. • Absorption of electronic transition has been used to fit the transmittance data. • Optical and dispersion parameters have been determined. - Abstract: ZnO, Zn 0.95 Co 0.05 O and Zn 0.90 Co 0.05 M 0.05 O (M=Al, Cd, Na, Cu) single phase films have been successfully synthesized by ultrasonic spray pyrolysis technique. Structural analysis by X-ray diffraction show that all the films have hexagonal wurtzite structure with an average crystallite size in the range of 19–25 nm. SEM analysis revealed that Cd and Na preserve the shape of nanopetals observed with ZnO or Co-ZnO films, while the doping with Al or Cu promote the formation of dense films constituted of nanorods. By the application of Levenberg–Marquardt least square method, the experimental transmittance data were fitted perfectly with the transmittance data calculated via a combination of Wemple–DiDomenico model, absorption coefficient of an electronic transition and Tauc–Urbach model. The concentration of absorbing centres N Co and oscillator strength f of d–d transition of Co 2+ ions are calculated from Smakula’s formula

  17. Luminescent properties of MAl(SO4)2 Br:Eu(3+) (M = Sr or Mg) red phosphors for near-UV light-emitting diodes.

    Science.gov (United States)

    Deshmukh, Priti B; Puppalwar, S P; Dhoble, N S; Dhoble, S J

    2015-02-01

    Eu(3+) -activated MAl(SO4 )2 Br phosphors (where M = Mg or Sr) are successfully prepared using a wet chemical reaction technique. The samples are characterized by X-ray diffraction (XRD) and photoluminescence (PL) spectroscopies. The XRD pattern revealed that both the samples are microcrystalline in nature. PL of Eu(3+) -doped SrAl(SO4 )2 Br and MgAl(SO4 )2 Br phosphors exhibited characteristic red emission coming from the (5) D0  → (7) F2 (616 nm) electron transition, when excited by 396 nm wavelength of light. The maximum intensity of luminescence was observed at a concentration of 1 mol% Eu(3+) . The intensity of the electric dipole transition at 616 nm is greater than that of the magnetic dipole transition at 594 nm. The results showed that MAl(SO4 )2 Br:Eu(3+) , (M = Mg, Sr) phosphors have potential application in near-UV light-emitting diodes as efficient red-emitting phosphor. Copyright © 2014 John Wiley & Sons, Ltd.

  18. Prostorové rozhraní informačního systému malé obce řešené v Open Source Software

    Directory of Open Access Journals (Sweden)

    Karel Jedlička

    2006-12-01

    Full Text Available Příspěvek si klade za cíl představit možnosti open source software pro implementaci prostorového rozhraní informačního systému malé obce.Zabývá se návrhem projektu po jednotlivých částech: identifikace požadavků zastupitelského úřadu (uživatele systému, popis obecné architektury systému a volba vhodných (nekomerčních technologií pro jeho implementaci. Součástí projektu je i popis vyvinuté technologie pro import nejdůležitějších datových vrstev (informací o vlastnictví do systému.Článek je doplněn výčtem využitelných datových zdrojů pro informační systém malé obce v České republice.

  19. Institucionalizacao da saude publica paulista nos anos 1930-1940

    Directory of Open Access Journals (Sweden)

    Andre Mota

    2013-10-01

    Full Text Available O objetivo do estudo foi interpretar e compreender a institucionalização da saúde pública paulista nos anos 1930-1940, com base na história das especialidades médicas. Foram analisadas novas fontes documentais em diálogo com a literatura existente, levando à identificação de novos indícios relativamente à questão eugênica e à presença de crenças religiosas de médicos como um movimento social. Os médicos, à medida que se especializavam como sanitaristas, propunham um projeto para elevar a raça brasileira, mesclando discursos higienistas com ações sanitárias. São Paulo buscou a primazia nesse projeto, por se acreditar um Estado detentor de uma raça já constituída de “homens historicamente saudáveis”. Crenças religiosas influenciaram o debate e as decisões de época para a ordem sanitária. Historicamente, o discurso sanitário compõe questões técnico-científicas com as político-ideológicas e as culturais, produzindo uma mescla dos diferentes interesses e perspectivas de ordem corporativa da profissão.

  20. Assédio moral nos ambientes corporativos

    Directory of Open Access Journals (Sweden)

    Yumara Lúcia Vasconcelos

    Full Text Available Resumo:Esse artigo teve como objetivo caracterizar o assédio moral nos ambientes corporativos à luz do paradigma conceitual do que se concebe como "dignidade humana" e violação do princípio jurídico da boa-fé. Especificamente, visou identificar padrões na argumentação jurídica e no enquadramento de práticas nocivas à saúde mental do trabalhador. O estudo, de natureza qualitativa, tomou por base o estudo de situações jurídicas, orientando-se pela demanda por definição e caracterização da prática assediadora no âmbito organizacional e dos limites do conceito da dignidade humana. Como principal resultado, o estudo colocou em contraste a necessidade de contextualização do fato propulsor da denúncia e caracterização do assédio, sem olvidar a relevância do significado ou sentido atribuído pelo indivíduo ao fenômeno analisado.

  1. Heterose em suínos na fase de aleitamento

    Directory of Open Access Journals (Sweden)

    José Bento Sterman Ferraz

    1991-12-01

    Full Text Available Visando avaliar o ganho de produtividade, advindo da heterose, no peso de suínos em fase de aleitamento, analisaram-se os pesos ao nascimento(PO, 21 dias de idade (P21 e desmama (PD de 746leitões, sendo 201 da raça Landrace, 136 Wessex-Saddleback e 409 mestiços, pelo método dos quadrados mínimos, considerando-se, ainda, os efeitos fixos de época e ano de nascimento, ordem do parto, sexo do leitão e tamanho da leitegada, além de raças paterna e materna e suas interações. Os efeitos não genéticos tiveram influência significativa em quase todas as características. Os mestiços mostraram, em geral, pesos superiores aos puros, com estimativas de heterose de 2,6% para PO, 9,7% para P21 e 13,9% para PD, indicando a importância da herança não aditiva à medida que os leitões ficam menos dependentes de suas mães. Os efeitos de interação entre as raças paterna e materna foram cada vez maiores com o avançar da idade. Os resultados indicam haver ganho de produtividade coma utilização deste tipo de cruzamento.

  2. Empirical support for a reclassification of eating disorders NOS.

    Science.gov (United States)

    Helverskov, J L; Lyng, B; Clausen, L; Mors, O; Frydenberg, M; Thomsen, P H; Rokkedal, K

    2011-01-01

    To explore the empirical support for a reclassification of the eating disorders NOS (EDNOS) category. In a cross-sectional design eight specific subgroups of EDNOS were compared to anorexia nervosa (AN) and bulimia nervosa (BN) on interview-based data and questionnaire measures. The sample consisted of 965 patients in the age 13-54 years admitted to treatment for an eating disorder. According to the DSM-IV 176(18%) presented with AN, 290(30%) with BN and 499(52%) with EDNOS. Of all EDNOS cases 34% could be reclassified as AN or BN. Three specific subgroups emerged as separate diagnostic entities. A heterogeneous subgroup of 122 patients (13% of all) was proposed as 'true' EDNOS. Implications of the results on the DSM-V are discussed. The results support a broader definition of AN and BN and suggest subgroups of EDNOS as separate diagnostic entities. This results in a substantial reduction of the heterogeneous EDNOS group. Copyright © 2010 John Wiley & Sons, Ltd and Eating Disorders Association.

  3. Identification of hamster inducible nitric oxide synthase (iNOS) promoter sequences that influence basal and inducible iNOS expression

    Science.gov (United States)

    Saldarriaga, Omar A.; Travi, Bruno L.; Choudhury, Goutam Ghosh; Melby, Peter C.

    2012-01-01

    IFN-γ/LPS-activated hamster (Mesocricetus auratus) macrophages express significantly less iNOS (NOS2) than activated mouse macrophages, which contributes to the hamster's susceptibility to intracellular pathogens. We determined a mechanism responsible for differences in iNOS promoter activity in hamsters and mice. The HtPP (1.2 kb) showed low basal and inducible promoter activity when compared with the mouse, and sequences within a 100-bp region (−233 to −133) of the mouse and hamster promoters influenced this activity. Moreover, within this 100 bp, we identified a smaller region (44 bp) in the mouse promoter, which recovered basal promoter activity when swapped into the hamster promoter. The mouse homolog (100-bp region) contained a cis-element for NF-IL-6 (−153/−142), which was absent in the hamster counterpart. EMSA and supershift assays revealed that the hamster sequence did not support the binding of NF-IL-6. Introduction of a functional NF-IL-6 binding sequence into the hamster promoter or its alteration in the mouse promoter revealed the critical importance of this transcription factor for full iNOS promoter activity. Furthermore, the binding of NF-IL-6 to the iNOS promoter (−153/−142) in vivo was increased in mouse cells but was reduced in hamster cells after IFN-γ/LPS stimulation. Differences in the activity of the iNOS promoters were evident in mouse and hamster cells, so they were not merely a result of species-specific differences in transcription factors. Thus, we have identified unique DNA sequences and a critical transcription factor, NF-IL-6, which contribute to the overall basal and inducible expression of hamster iNOS. PMID:22517919

  4. Subjetividade e projetos coletivos: mal-estar e governabilidade nas organizações de saúde Subjectivity and collective projects: discontents and governability in health organizations

    Directory of Open Access Journals (Sweden)

    Marilene de Castilho Sá

    2001-01-01

    Full Text Available O presente texto procura explorar algumas questões derivadas das relações entre subjetividade, processos intersubjetivos/grupais e processos de planejamento e gestão nas organizações de saúde. Essa problemática tem-se destacado, fundamentalmente, a partir da constatação dos obstáculos à implementação dos processos de mudança nas organizações, bem como dos limites dos instrumentais teórico-metodológicos disponíveis em planejamento e gestão para favorecer tais processos. O setor saúde no Brasil tem sido, simultânea e paradoxalmente, espaço de experimentação de propostas inovadoras nos campos da assistência e da gestão pública, bem como locus privilegiado de manifestação das contradições sociais e do intenso processo de exclusão, segregação e desvalorização da vida que tem marcado nossa sociedade. Neste contexto, o que nos interessa essencialmente examinar é até que ponto é viável a construção de projetos coletivos, no âmbito das organizações de saúde, e como é possível abordar suas dimensões cultural, subjetiva e inconsciente - condição, nos parece, indispensável para se aprender sobre os limites (e possibilidades de governabilidade dessas organizações.This paper explores some topics regarding the relations among subjectivity, group processes and planning and management processes within health organizations. These issues turn out to be important when we consider the obstacles involved in the organizational change processes, as well as the limitations of management theoretical and methodological tools in subsidizing these processes. Health sector in Brazil has been, simultaneously and paradoxically, a space for innovations in health assistance and public management, as well as the privileged locus for the social contradictions and for the intense exclusion, segregation and undervaluation of life in our society. In this context, we are particularly interested in examine the possibilities of

  5. St36 electroacupuncture activates nNOS, iNOS and ATP-sensitive potassium channels to promote orofacial antinociception in rats.

    Science.gov (United States)

    Almeida, R T; Galdino, G; Perez, A C; Silva, G; Romero, T R; Duarte, I D

    2017-02-01

    Orofacial pain is pain perceived in the face and/or oral cavity, generally caused by diseases or disorders of regional structures, by dysfunction of the nervous system, or through referral from distant sources. Treatment of orofacial pain is mainly pharmacological, but it has increased the number of reports demonstrating great clinical results with the use of non-pharmacological therapies, among them electroacupuncture. However, the mechanisms involved in the electroacupuncture are not well elucidated. Thus, the present study investigate the involvement of the nitric oxide synthase (NOS) and ATP sensitive K + channels (KATP) in the antinociception induced by electroacupuncture (EA) at acupoint St36. Thermal nociception was applied in the vibrissae region of rats, and latency time for face withdrawal was measured. Electrical stimulation of acupoint St36 for 20 minutes reversed the thermal withdrawal latency and this effect was maintained for 150 min. Intraperitoneal administration of specific inhibitors of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS) and a KATP channels blocker reversed the antinociception induced by EA. Furthermore, nitrite concentration in cerebrospinal fluid (CSF) and plasma, increased 4 and 3-fold higher, respectively, after EA. This study suggests that NO participates of antinociception induced by EA by nNOS, iNOS and ATP-sensitive K + channels activation.

  6. Electroacupuncture Delays Hypertension Development through Enhancing NO/NOS Activity in Spontaneously Hypertensive Rats

    Directory of Open Access Journals (Sweden)

    Hye Suk Hwang

    2011-01-01

    Full Text Available Using spontaneously hypertensive rats (SHR, this study investigated whether electroacupuncture (EA could reduce early stage hypertension by examining nitric oxide (NO levels in plasma and nitric oxide synthase (NOS levels in the mesenteric resistance artery. EA was applied to the acupuncture point Governor Vessel 20 (GV20 or to a non-acupuncture point in the tail twice weekly for 3 weeks under anesthesia. In conscious SHR and normotensive Wistar Kyoto (WKY rats, blood pressure was determined the day after EA treatment by the tail-cuff method. We measured plasma NO concentration, and evaluated endothelial NO syntheses (eNOS and neuronal NOS (nNOS protein expression in the mesenteric artery. Systolic blood pressure (SBP and diastolic blood pressure (DBP were lower after 3 weeks of GV20 treatment than EA at non-acupuncture point and no treatment control in SHR. nNOS expression by EA was significantly different between both WKY and no treatment SHR control, and EA at GV20 in SHR. eNOS expression was significantly high in EA at GV 20 compared with no treatment control. In conclusion, EA could attenuate the blood pressure elevation of SHR, along with enhancing NO/NOS activity in the mesenteric artery in SHR.

  7. Identification and molecular characterization of nitric oxide synthase (NOS) gene in the intertidal copepod Tigriopus japonicus.

    Science.gov (United States)

    Jeong, Chang-Bum; Kang, Hye-Min; Seo, Jung Soo; Park, Heum Gi; Rhee, Jae-Sung; Lee, Jae-Seong

    2016-02-10

    In copepods, no information has been reported on the structure or molecular characterization of the nitric oxide synthase (NOS) gene. In the intertidal copepod Tigriopus japonicus, we identified a NOS gene that is involved in immune responses of vertebrates and invertebrates. In silico analyses revealed that nitric oxide (NO) synthase domains, such as the oxygenase and reductase domains, are highly conserved in the T. japonicus NOS gene. The T. japonicus NOS gene was highly transcribed in the nauplii stages, implying that it plays a role in protecting the host during the early developmental stages. To examine the involvement of the T. japonicus NOS gene in the innate immune response, the copepods were exposed to lipopolysaccharide (LPS) and two Vibrio sp. After exposure to different concentrations of LPS and Vibrio sp., T. japonicus NOS transcription was significantly increased over time in a dose-dependent manner, and the NO/nitrite concentration increased as well. Taken together, our findings suggest that T. japonicus NOS transcription is induced in response to an immune challenge as part of the conserved innate immunity. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Tratamento adjuvante nos GISTs Adjuvant treatment in GISTs

    Directory of Open Access Journals (Sweden)

    Laercio Gomes Lourenço

    2011-09-01

    Full Text Available INTRODUÇÃO: O tumor estromal gastrointestinal (GIST é o sarcoma mais comum do aparelho digestivo. Essa neoplasia ocorre devido à mutação do gene KIT com consequente ativação constitutiva da proteína KIT. O tratamento primário é cirúrgico e consiste na sua ressecção completa. Entretanto, alguns grupos de pacientes apresentam risco elevado de recorrência mesmo após operação com ressecção completa (R0, indicando diferenças no comportamento biológico. Estudos clínicos comprovaram a atividade clínica do mesilato de imatinibe, fazendo dele a primeira linha de tratamento padrão nos GISTs metastáticos ou irressecáveis, mudando muito o desfecho clínico dessa doença em relação aos benefícios anteriormente obtidos com a quimioterapia antineoplásica. MÉTODO: Foi realizada revisão da literatura com consulta nos periódicos das bases Medline/Pubmed, Scielo e Lilacs cruzando os descritores: tumor estromal gastrointestinal, Gist, tratamento, adjuvância. Além desta revisão foi adicionada a experiência pessoal dos autores. CONCLUSÃO: Melhor refinamento dos critérios de prognóstico tem permitido selecionar de forma mais adequada pacientes para o tratamento adjuvante com imatinibe. Os resultados de maior evidência até o momento respaldam o tratamento adjuvante por um ano, o que produz benefício significativo na sobrevida livre de recidiva, mas não na sobrevida global desses pacientes.INTRODUCTION: Gastrointestinal stromal tumor (GIST is the most common sarcoma of the digestive tract. This cancer occurs due to mutation of the KIT gene resulting in constitutive activation of KIT protein. The primary treatment is surgical and consists of complete resection. However, some groups of patients at high risk of recurrence even after surgery with complete resection (R0, indicate differences in biological behavior. Clinical studies have demonstrated the clinical activity of imatinib mesylate, making it the standard first

  9. Ejercicio y la detección del mal agudo de montaña grave Exercise and the detection of severe acute mountain sickness

    Directory of Open Access Journals (Sweden)

    Adrián Garófoli

    2010-02-01

    Full Text Available El mal agudo de montaña (MAM es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2.700 m y 4 300 m en 63 sujetos que ascendían al cerro Aconcagua (6 962 m. Se consideró desaturación de oxígeno con ejercicio a una disminución = 5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. Seis sujetos presentaron MAM grave (9.5% y requirieron evacuación. La saturación de oxígeno en reposo a 2.700 m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2.700 m más la saturación inapropiada en reposo a 4.300 m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave.Acute mountain sickness (AMS is a group of non-specific symptoms, seen in subjects that ascend from low to high altitude too quickly, without allowing sufficient time to acclimatize. Usually it is self-limiting, but the severe forms (pulmonary and cerebral edema can be fatal. Exaggerated hypoxemia at rest is related to later development of AMS but its predictive value is limited. Since exercise at altitude induces greater hypoxemia and

  10. Factores asociados a mal estado de salud percibido o a mala calidad de vida en personas mayores de 65 años

    Directory of Open Access Journals (Sweden)

    Azpiazu Garrido Mercedes

    2002-01-01

    Full Text Available Fundamento: Hoy en día, en los países desarrollados, llegar a una edad avanzada ha dejado de ser algo excepcional, sin embargo muchas personas no logran envejecer con una buena calidad de vida. El presente trabajo tiene como objetivos, contribuir a un mejor conocimiento de los principales factores que influyen en la calidad de vida y la percepción de la salud de los mayores de 65 años, así como determinar qué ventajas y desventajas presenta cada uno de los tres instrumentos de medida de la salud y la calidad de vida frente a los otros dos instrumentos utilizados. Métodos: A partir de 911 encuestas a personas mayores de 65 años no institucionalizadas, realizadas a domicilio, se hizo un análisis multivariante mediante regresión logística, poniendo en relación los resultados obtenidos en el Perfil de Salud de Nottingham (PSN, el Euroqol y el EAS con las caracterísiticas sociodemográficas, el nivel de recursos económicos, el grado de apoyo sociofamiliar, el estado de salud física y mental y la capacidad funcional. Resultados: Los principales factores que se asocian con la percepción de un mal estado de salud y mala calidad de vida en el Euroqol y el PSN son los trastornos de ansiedad (Odd Ratios entre 1,8(IC:1,2-2,8 para movilidad y 7,9(IC:4,5-13,9 para Perfil ≠11111, trastornos depresivos (OR:1,8(IC:1,3-2,6 para dolor/malestar- 3,3(IC:2,1-5,1 para aislamiento social, falta de ejercicio (OR:1,4 (IC:1-2,1 para ansiedad/depresión -3,9(IC:2,5-6,2 para actividades cotidianas, dependencia para las actividades básicas de la vida diaria (OR:0,5(IC:0,3-0,9 para reacción emocional - 4,8(IC:3-7,6 para actividades cotidianas y dependencia para las actividades instrumentales de la vida diaria (OR:1,5(IC:1,1-2,1 para Escala Visual Analógicac<70 - 7,1(IC:2,9-17,2 para cuidado personal. Conclusiones: La salud mental y la capacidad funcional son los factores que más influyen en la percepción del estado de salud y la calidad de vida de las

  11. (INTERSUBJETIVIDADE NOS ESTUDOS DE REDES SOCIAIS: DISSOLVENDO FRONTEIRAS

    Directory of Open Access Journals (Sweden)

    Sayonara Costa

    2014-07-01

    Full Text Available As redes sociais da internet (RSI se multiplicam e todas elas, embora tenham esquemas enunciativos distintos, ampliam as possibilidades de por em cena (intersubjetividades. Muitos papeis sociais são desempenhados nesses ambientes digitais que dão guarida às múltiplas faces de um sujeito que se (desconstrói em meio a um processo heterogêneo. Diante disso, a pergunta que norteia esse ensaio é: Como estudar esse processo de (desconstrução da subjetividade em redes sociais? A proposição que defendemos neste trabalho é a de que o sujeito adepto das redes sociais da internet encontra-se em um tempo-espaço propício a excitações que vão muito além das percepções idiossincráticas de cada indivíduo. Em função disso, propomos que estudar as (intersubjetividades nas RSI pode ser produtivo se relacionarmos as noções de caosmose (Guattari, self (Goffman e enunciação linguística (Benveniste. A conclusão a que chegamos é a de que o viés da enunciação linguística pode ser uma alternativa metodológica que auxilie na conexão entre uma concepção mais transversalista da subjetividade e a tese de que a interação social assemelha-se a uma encenação teatral e, por isso, pode tomar rumos diversos, de acordo com roteiros pré-estabelecidos e socialmente partilhados nos cenários digitais das RSI.

  12. Macrophages activate iNOS signaling in adventitial fibroblasts and contribute to adventitia fibrosis.

    Science.gov (United States)

    Zhang, Guannan; Li, Xiaodong; Sheng, Chengyu; Chen, Xiaohui; Chen, Yu; Zhu, Dingliang; Gao, Pingjin

    2016-12-30

    A large amount of NO is generated through the inducible nitric oxide synthase (iNOS) pathway from the vascular adventitia in various vascular diseases. However, it is currently not fully understood how the iNOS signaling pathway is activated. In the present study, this question was addressed in the context of adventitial cellular interactions. A rat model of acute hypertension in the contralateral carotid arteries was established through transverse aortic constriction (TAC) surgery. In this model, activated macrophages were found surrounded by a large quantity of iNOS-expressing adventitial fibroblasts (AFs), suggesting a possible causal relationship between macrophages and iNOS activation of the neighboring AFs. In an in vitro model, a macrophage-like cell line RAW 264.7 was first activated by LPS treatment. The supernatant was then harvested and applied to treat primary rat AFs. iNOS in AFs was activated robustly by the supernatant treatment but not by LPS itself. Treating AFs with interleukin-1β (IL-1β) also activated iNOS signaling, suggesting that the IL-1β pathway might be a possible mediator. As a consequence of the iNOS activation, total protein nitration and S-nitrosylation significantly increased in those AFs. Additionally, increased deposition of type I and type III collagens was observed in both in vitro and in vivo models. The collagen deposition was partially restored by an iNOS inhibitor, 1400 W. These findings highlight the importance of iNOS signaling during vascular inflammation, and advance our understanding of its activation through a cellular interaction perspective. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. iNOS inhibits hair regeneration in obese diabetic (ob/ob) mice.

    Science.gov (United States)

    Sasaki, Mari; Shinozaki, Shohei; Morinaga, Hironobu; Kaneki, Masao; Nishimura, Emi; Shimokado, Kentaro

    2018-07-02

    Previous studies have shown that androgenic alopecia is associated with metabolic syndrome and diabetes. However, the detailed mechanism whereby diabetes causes alopecia still remains unclear. We focused on the inflammatory response that is caused by diabetes or obesity, given that inflammation is a risk factor for hair loss. Inducible nitric oxide synthase (iNOS) is known to be upregulated under conditions of acute or chronic inflammation. To clarify the potential role of iNOS in diabetes-related alopecia, we generated obese diabetic iNOS-deficient (ob/ob; iNOS-KO mice). We observed that ob/ob; iNOS-KO mice were potentiated for the transition from telogen (rest phase) to anagen (growth phase) in the hair cycle compared with iNOS-proficient ob/ob mice. To determine the effect of nitric oxide (NO) on the hair cycle, we administered an iNOS inhibitor intraperitoneally (compound 1400 W, 10 mg/kg) or topically (10% aminoguanidine) in ob/ob mice. We observed that iNOS inhibitors promoted anagen transition in ob/ob mice. Next, we administered an NO donor (S-nitrosoglutathione, GSNO), to test whether NO has the telogen elongation effects. The NO donor was sufficient to induce telogen elongation in wild-type mice. Together, our data indicate that iNOS-derived NO plays a role in telogen elongation under the inflammatory conditions associated with diabetes in mice. Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

  14. Technical Specifications: Vogtle Electric Generating Plant, Unit Nos. 1 and 2 (Docket Nos. 50-424 and 50-425): Appendix ''A'' to License Nos. NPF-68 and NPF-79

    International Nuclear Information System (INIS)

    1989-02-01

    The Vogtle Electric Generating Plant, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear facility as set forth in Section 50.36 of 10 CFR 50 for the protection of the health and safety of the public

  15. Technical Specifications, Vogtle Electric Generating Plant, Unit Nos. 1 and 2 (Docket Nos. 50-424 and 50-425): Appendix ''A'' to License Nos. NPF-68 and NPF-81

    International Nuclear Information System (INIS)

    1989-03-01

    The Vogtle Electric Generating Plant, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear facility as set forth in Section 50.36 of 10 CFR 50 for the protection of the health and safety of the public

  16. Technical Specifications, South Texas Project, Unit Nos. 1 and 2 (Docket Nos. 50-498 and 50-499): Appendix ''A'' to License Nos. NPF-76 and NPF-80

    International Nuclear Information System (INIS)

    1989-03-01

    The South Texas Project, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  17. Technical specifications, South Texas Project, Unit Nos. 1 and 2 (Docket Nos. 50-498 and 50-499): Appendix ''A'' to License Nos. NPF-76 and NPF-78

    International Nuclear Information System (INIS)

    1989-01-01

    The South Texas Project, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public

  18. Genesis of the Assif El Mal Zn-Pb (Cu, Ag) vein deposit. An extension-related Mesozoic vein system in the High Atlas of Morocco. Structural, mineralogical, and geochemical evidence

    Science.gov (United States)

    Bouabdellah, M.; Beaudoin, G.; Leach, D.L.; Grandia, F.; Cardellach, E.

    2009-01-01

    The Assif El Mal Zn-Pb (Cu-Ag) vein system, located in the northern flank of the High Atlas of Marrakech (Morocco), is hosted in a Cambro-Ordovician volcaniclastic and metasedimentary sequence composed of graywacke, siltstone, pelite, and shale interlayered with minor tuff and mudstone. Intrusion of synorogenic to postorogenic Late Hercynian peraluminous granitoids has contact metamorphosed the host rocks giving rise to a metamorphic assemblage of quartz, plagioclase, biotite, muscovite, chlorite, amphibole, chloritoid, and garnet. The Assif El Mal Zn-Pb (Cu-Ag) mineralization forms subvertical veins with ribbon, fault breccia, cockade, comb, and crack and seal textures. Two-phase liquid-vapor fluid inclusions that were trapped during several stages occur in quartz and sphalerite. Primary inclusion fluids exhibit Th mean values ranging from 104??C to 198??C. Final ice-melting temperatures range from -8.1??C to -12.8??C, corresponding to salinities of ???15 wt.% NaCl equiv. Halogen data suggest that the salinity of the ore fluids was largely due to evaporation of seawater. Late secondary fluid inclusions have either Ca-rich, saline (26 wt.% NaCl equiv.), or very dilute (3.5 wt.% NaCl equiv.) compositions and homogenization temperatures ranging from 75??C to 150??C. The ??18O and ??D fluid values suggest an isotopically heterogeneous fluid source involving mixing between connate seawater and black-shale-derived organic waters. Low ??13CVPDB values ranging from -7.5??? to -7.7??? indicate a homogeneous carbon source, possibly organic matter disseminated in black shale hosting the Zn-Pb (Cu-Ag) veins. The calculated ??34SH2S values for reduced sulfur (22.5??? to 24.3???) are most likely from reduction of SO42- in trapped seawater sulfate or evaporite in the host rocks. Reduction of sulfate probably occurred through thermochemical sulfate reduction in which organic matter was oxidized to produce CO2 which ultimately led to precipitation of saddle dolomite with

  19. Malária em grávidas de uma maternidade pública de Rio Branco (Acre, Brasil Malaria in pregnant women of a public maternity of Rio Branco (Acre State, Brazil

    Directory of Open Access Journals (Sweden)

    Regina Jarude

    2003-04-01

    Full Text Available OBJETIVO: descrever a freqüência dos achados clínico-laboratoriais em grávidas portadoras de malária. MÉTODOS: foi realizado estudo descritivo, série de casos, de 445 grávidas da Maternidade e Clínica de Mulheres Bárbara Heliodora (Rio Branco, Acre, do período de janeiro de 1996 a dezembro de 2001, com diagnóstico parasitológico de malária. Foram revistos os prontuários do período e selecionados os casos portadores de malária. RESULTADOS: no total de pacientes (n=33.420 internadas no período, estavam incluídas 445 (1,4% grávidas. Entre essas, a freqüência da infecção por Plasmodium vivax foi de 52,8% (n=235, por P. falciparum, de 43,8% (n=195, e 3,4% (n=15 por ambos os plasmódios. As alterações clínico-laboratoriais mais freqüentes (pPURPOSE: to describe the frequency of clinical and laboratorial findings in pregnant women with malaria. METHODS: a descriptive study was performed including 445 pregnant women with a positive diagnosis of malaria of the Maternity and women's Clinic Bárbara Heliodora (Rio Branco, Acre State, from January 1996 to December 2001. These cases were reviewed and the pregant women with malaria were selected. RESULTS: a total of 33,420 patients were hospitalized in that period. Of these, 445 pregnant women (1.4% were included. Among these, the frequency of the infection with Plasmodium vivax was 52.8% (n=235, with P. falciparum, 43.8% (n=195, and 3.4% (n=15 with both plasmodia. The most frequent clinical and laboratorial alterations (p<0.05 were observed in the patients with P. falciparum: pale mucosa, jaundice hemoglobin and hematocrit decrease, hypoglycemia and increase in serum aminotransferase, urea, creatinine and in bilirubin levels. Only one patient (1/445, a pregnant woman infected with P. falciparum died. Abortions, premature birth and low birth weight were detected in 1.3, 1.1 and 1.1% of the cases, respectively. CONCLUSIONS: these findings reflect the repercussion of malaria during

  20. Mercury exposure and malaria prevalence among gold miners in Pará, Brazil Exposição a mercúrio e prevalência de malária entre garimpeiros de ouro do Pará, Brasil

    Directory of Open Access Journals (Sweden)

    Ellen K. Silbergeld

    2002-10-01

    Full Text Available Economic development, including resource extraction, can cause toxic exposures that interact with endemic infectious diseases. Mercury is an immunotoxic metal used in the amalgamation of gold, resulting in both occupational exposures and environmental pollution. A cross-sectional medical survey was conducted in 1997 on 135 garimpeiros in Para, Brazil, because of their risks of both mercury exposure and malaria transmission. Mean levels of blood and urine mercury were well above non-exposed background levels. Twenty-six subjects had malaria parasitemia: Health symptoms consistent with mercury exposure were reported, but neither symptoms nor signs correlated with mercury levels in blood or urine. We did not find a dose response relationship between mercury exposure and likelihood of prevalent malaria infection, but there was a possible reduction in acquisition of immunity that may be associated with conditions in gold mining, including mercury exposure.O desenvolvimento econômico, incluindo extração de recursos naturais, pode causar exposições tóxicas que interagem com doenças infecciosas endêmicas. O mercúrio é um metal imunotóxico usado na amalgamação do ouro, resultando em exposição ocupacional e poluição ambiental. Devido aos riscos da exposição ao mercúrio e transmissão de malária em 135 garimpeiros do Pará, Brasil, uma avaliação médica "cross-sectional" foi coduzida em 1997. Níveis médios de mercúrio no sangue e na urina encontram-se bem acima dos níveis basais daqueles não expostos. Vinte e seis indivíduos apresentaram parasitemia de malária; sintomas relacionados com exposição ao mercúrio foram adquiridos, mas nenhum dos sintomas/sinais está correlacionado com níveis de mercúrio no sangue ou na urina. Não foi encontrada nenhuma relação de dose-resposta entre exposição ao mercúrio e provável infecção de malária prevalente. Entretanto, verificou-se uma possível redução na aquisição de

  1. História e oralidade nos estudos comunicacionais

    Directory of Open Access Journals (Sweden)

    Juniele Rabêlo Almeida

    2016-05-01

    Full Text Available Concepções, métodos e formas do conhecimento histórico são expressos em diversos estudos na área de comunicação social. Buscamos analisar, na interface história e narrativa oral, aspectos da chamada mediação cultural, na qual a comunicação está para além da condição de canal. Acreditamos que os estudos comunicacionais não recaem, necessariamente, sobre especificidades técnicas, mas sobre a posição que a comunicação assume no campo histórico-cultural. Interações, expressas nos trabalhos de história oral, se configuram (e resultam em processos comunicacionais que indicam construções sócio históricas e diferentes referenciais de pertencimento. Palavras-chave: Estudos comunicacionais, História, Narrativas Orais.   Abstract: Conceptions, methods and historical knowledge forms are expressed in several studies in the area of social communication. We analyze, history and oral narrative interface, called aspects of cultural mediation, in which the communication is in addition to the channel condition. We believe that communication studies do not fall necessarily on technicalities, but on the position that the communication is in the historical-cultural field. Interactions, expressed in the works of oral history, are configured (and result in communication processes that indicate historical social constructions and different frames of belonging. Keywords: communication Studies, History, Oral Narratives.   Resumen: Conceptos, métodos y formas de conocimiento histórico se expresan en varios estudios en el área de la comunicación social. Analizamos, la historia y la interfaz de la narrativa oral, llamados aspectos de mediación cultural, en el que la comunicación es, además de la condición de canal. Creemos que los estudios de comunicación no caen necesariamente en técnicos, sino a la posición de que la comunicación es en el campo histórico-cultural. Interacciones, expresados en las obras de la historia oral, est

  2. NOS CO-OPS Water Level Data, High Low Tide Prediction

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has High Low Tide Predictions from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). The official Tide and Tidal Current...

  3. NOS CO-OPS Water Level Data, Tide Prediction, 60-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has High Low Tide Predictions from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). The official Tide and Tidal Current...

  4. NODC Standard Format NOS Coastal Wave Program (F182) Data (1979-1983) (NODC Accession 0014203)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data type was designed for analyzed wave data originating from the National Ocean Service (NOS) Coastal Wave Program. The data are organized into 3 record...

  5. NOS CO-OPS Water Level Data, Tide Prediction, 6-Minute

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset has High Low Tide Predictions from NOAA NOS Center for Operational Oceanographic Products and Services (CO-OPS). The official Tide and Tidal Current...

  6. Opava (K. Ú. Kateřinky, Malé Hoštice, okres Opava). " Na hoštických lukách". Doba laténská. Sídliště. Záchranný výzkum.

    Czech Academy of Sciences Publication Activity Database

    Juchelka, Jiří

    2009-01-01

    Roč. 50, 1-2 (2009), s. 312 ISSN 1211-7250 Institutional research plan: CEZ:AV0Z80010507 Keywords : Czech Silesia * Malé Hoštice * Latén Cultur e Subject RIV: AC - Archeology, Anthropology, Ethnology

  7. Endogenous angiotensin II modulates nNOS expression in renovascular hypertension

    Directory of Open Access Journals (Sweden)

    T.M.C. Pereira

    2009-07-01

    Full Text Available Nitric oxide (NO influences renal blood flow mainly as a result of neuronal nitric oxide synthase (nNOS. Nevertheless, it is unclear how nNOS expression is modulated by endogenous angiotensin II, an inhibitor of NO function. We tested the hypothesis that the angiotensin II AT1 receptor and oxidative stress mediated by NADPH oxidase contribute to the modulation of renal nNOS expression in two-kidney, one-clip (2K1C hypertensive rats. Experiments were performed on male Wistar rats (150 to 170 g body weight divided into 2K1C (N = 19 and sham-operated (N = 19 groups. nNOS expression in kidneys of 2K1C hypertensive rats (N = 9 was compared by Western blotting to that of 2K1C rats treated with low doses of the AT1 antagonist losartan (10 mg·kg-1·day-1; N = 5 or the superoxide scavenger tempol (0.2 mmol·kg-1·day-1; N = 5, which still remain hypertensive. After 28 days, nNOS expression was significantly increased by 1.7-fold in the clipped kidneys of 2K1C rats and by 3-fold in the non-clipped kidneys of 2K1C rats compared with sham rats, but was normalized by losartan. With tempol treatment, nNOS expression increased 2-fold in the clipped kidneys and 1.4-fold in the non-clipped kidneys compared with sham rats. The changes in nNOS expression were not followed by changes in the enzyme activity, as measured indirectly by the cGMP method. In conclusion, AT1 receptors and oxidative stress seem to be primary stimuli for increased nNOS expression, but this up-regulation does not result in higher enzyme activity.

  8. Angiotensin II blockade causes acute renal failure in eNOS-deficient mice

    Directory of Open Access Journals (Sweden)

    Jürgen Schnermann

    2001-03-01

    Full Text Available Compared with wild-type mice, adult endothelial nitric oxide synthase (eNOS knockout mice (eight months of age have increased blood pressure (BP (126±9 mmHg vs. 100±4 mmHg, and an increased renal vascular resistance (155±16 vs. 65±4 mmHg.min/ml. Renal vascular resistance responses to i.v. administration of noradrenaline were markedly enhanced in eNOS knockout mice. Glomerular filtration rate (GFR of anaesthetised eNOS -/- mice was 324±57 µl/min gKW, significantly lower than the GFR of 761±126 µl/min.gKW in wild-type mice. AT1-receptor blockade with i.v. candesartan (1—1.5 mg/kg reduced arterial blood pressure and renal vascular resistance, and increased renal blood flow (RBF to about the same extent in wild-type and eNOS -/- mice. Candesartan did not alter GFR in wild-type mice (761±126 vs. 720±95 µl/min.gKW, but caused a marked decrease in GFR in eNOS -/- mice (324.5±75.2 vs. 77±18 µl/min.gKW. A similar reduction in GFR of eNOS deficient mice was also caused by angiotensin-converting enzyme (ACE inhibition. Afferent arteriolar granularity, a measure of renal renin expression, was found to be reduced in eNOS -/- compared with wild-type mice. In chronically eNOS-deficient mice, angiotensin II (Ang II is critical for maintaining glomerular filtration pressure and GFR, presumably through its effect on efferent arteriolar tone.

  9. A central role of eNOS in the protective effect of wine against metabolic syndrome.

    Science.gov (United States)

    Leighton, Federico; Miranda-Rottmann, Soledad; Urquiaga, Inés

    2006-01-01

    The positive health effects derived from moderate wine consumption are pleiotropic. They appear as improvements in cardiovascular risk factors such as plasma lipids, haemostatic mechanisms, endothelial function and antioxidant defences. The active principles would be ethanol and mainly polyphenols. Results from our and other laboratories support the unifying hypothesis that the improvements in risk factors after red wine consumption are mediated by endothelial nitric oxide synthase (eNOS). Many genes are involved, but the participation of eNOS would be a constant feature. The metabolic syndrome is a cluster of metabolic risk factors associated with high risk of cardiovascular disease (CVD). The National Cholesterol Education Programmmes Adult Treatment Panel III (NCEPATP III) clinical definition of the metabolic syndrome requires the presence of at least three risk factors, from among abdominal obesity, high plasma triacylglycerols, low plasma HDL, high blood pressure and high fasting plasma glucose. The molecular mechanisms responsible for the metabolic syndrome are not known. Since metabolic syndrome apparently affects 10-30% of the population in the world, research on its pathogenesis and control is needed. The recent finding that eNOS knockout mice present a cluster of cardiovascular risk factors comparable to those of the metabolic syndrome suggests that defects in eNOS function may cause human metabolic syndrome. These mice are hypertensive, insulin resistant and dyslipidemic. Further support for a pathogenic role of eNOS comes from the finding in humans that eNOS polymorphisms associate with insulin resistance and diabetes, with hypertension, with inflammatory and oxidative stress markers and with albuminuria. So, the data sustain the hypothesis that eNOS enhancement should reduce metabolic syndrome incidence and its consequences. Therefore red wine, since it enhances eNOS function, should be considered as a potential tool for the control of metabolic

  10. Activation of Endothelial Nitric Oxide (eNOS Occurs through Different Membrane Domains in Endothelial Cells.

    Directory of Open Access Journals (Sweden)

    Jason Tran

    Full Text Available Endothelial cells respond to a large range of stimuli including circulating lipoproteins, growth factors and changes in haemodynamic mechanical forces to regulate the activity of endothelial nitric oxide synthase (eNOS and maintain blood pressure. While many signalling pathways have been mapped, the identities of membrane domains through which these signals are transmitted are less well characterized. Here, we manipulated bovine aortic endothelial cells (BAEC with cholesterol and the oxysterol 7-ketocholesterol (7KC. Using a range of microscopy techniques including confocal, 2-photon, super-resolution and electron microscopy, we found that sterol enrichment had differential effects on eNOS and caveolin-1 (Cav1 colocalisation, membrane order of the plasma membrane, caveolae numbers and Cav1 clustering. We found a correlation between cholesterol-induced condensation of the plasma membrane and enhanced high density lipoprotein (HDL-induced eNOS activity and phosphorylation suggesting that cholesterol domains, but not individual caveolae, mediate HDL stimulation of eNOS. Vascular endothelial growth factor (VEGF-induced and shear stress-induced eNOS activity was relatively independent of membrane order and may be predominantly controlled by the number of caveolae on the cell surface. Taken together, our data suggest that signals that activate and phosphorylate eNOS are transmitted through distinct membrane domains in endothelial cells.

  11. L'evolució del rol dramàtic de la Bella Dorment i Malèfica a les adaptacions cinematogràfiques homònimes de 1959 i 2014

    OpenAIRE

    Escobar Pérez, Marina

    2015-01-01

    Aquest treball de recerca i investigació és el resultat d'un anàlisi qualitatiu i de gènere realitzat d'acord amb la teoria audiovisual narrativa i la teoria fílmica feminista sobre la representació cinematogràfica dels personatges de la Bella Dorment i Malèfica a les pel•lícules homònimes dels anys 1959 i 2014 amb l'objectiu de determinar l'evolució del seu rol dramàtic. Este trabajo de investigación es el resultado de un análisis cualitativo y de género realizado en base a la teoría audi...

  12. Associations between chewing lice (Insecta, Phthiraptera and albatrosses and petrels (Aves, Procellariiformes collected in Brazil Associações entre malófagos (Insecta, Phthiraptera e albatrozes e petréis (Aves, Procellariiformes capturados no Brasil

    Directory of Open Access Journals (Sweden)

    Michel P. Valim

    2006-12-01

    Full Text Available Chewing lice were searched on 197 skins of 28 species of procellariiform birds collected in Brazil. A total of 38 species of lice were found on 112 skins belonging to 22 bird species. The lice were slide-mounted and identified. A list of lice species found and their host species is given and some host-louse associations are discussed under an evolutionary perspective.Malófagos foram procurados em 197 peles de 28 espécies de aves Procellariiformes capturadas no Brasil. Um total de 38 espécies de piolhos foram encontradas em 112 peles pertencentes a 22 espécies de aves. Os piolhos foram montados em lâminas e identificados. Uma lista com as espécies de piolhos encontradas e seus hospedeiros é dada, além de algumas associações entre os piolhos e as aves serem discutidas sob uma perspectiva evolutiva.

  13. Malaria diagnosis and treatment under the strategy of the integrated management of childhood illness (IMCI): relevance of laboratory support from the rapid immunochromatographic tests of ICT Malaria P.f/P.v and OptiMal

    DEFF Research Database (Denmark)

    Tarimo, D S; Minjas, J N; Bygbjerg, I C

    2001-01-01

    to be excluded as a cause of illness (e.g. prior to treatment with toxic or expensive drugs, or during malaria epidemics). Wherever the effective drugs for the first-line treatment of malaria are cheap (e.g. chloroquine and Fansidar), treatment based on clinical diagnosis alone should prove cost-saving in health...... significantly associated with the P. falciparum asexual parasitaemias that equalled or exceeded the threshold intensity (2000/microl) that has the optimum sensitivity and specificity for the definition of a malarial episode. Diagnostic likelihood ratios (DLR) showed that a positive result in the OptiMal test....... Although the RIT may seem attractive for use in primary health facilities because relatively inexperienced staff can perform them, the high cost of these tests is prohibitive. In holo-endemic areas, use of RIT or microscopical examination of bloodsmears may only be relevant when malaria needs...

  14. Technical specifications, Braidwood Station, Unit Nos. 1 and 2 (Docket Nos. STN 50-456 and STN 50-457): Appendix ''A'' to License No. NPF-70

    International Nuclear Information System (INIS)

    1987-05-01

    The Braidwood Station, Unit Nos. 1 and 2, Technical Specifications were prepared by the US Nuclear Regulatory Commission to set forth the limits, operating conditions, and other requirements applicable to a nuclear reactor facility as set forth in Section 50.36 of 10 CFR Part 50 for the protection of the health and safety of the public. 18 figs., 55 tabs

  15. Conformance to Regulatory Guide 1.97, Shearon Harris Nuclear Power Plant, Unit Nos. 1 and 2 (Docket Nos. 50-400 and 50-401)

    International Nuclear Information System (INIS)

    Stoffel, J.W.

    1985-09-01

    This EG and G Idaho, Inc. report reviews the submittals for Regulatory Guide 1.97, Revision 3, for Unit Nos. 1 and 2 of the Shearon Harris Nuclear Power Plant and identifies areas of nonconformance to the regulatory guide. Exceptions to Regulatory Guide 1.97 are evaluated and those areas where sufficient basis for acceptability is not provided are identified. 7 refs

  16. Conformance to Regulatory Guide 1.97, Perry Nuclear Power Plant, Unit Nos. 1 and 2 (Docket Nos. 50-440 and 50-441)

    International Nuclear Information System (INIS)

    Udy, A.C.

    1985-03-01

    This EG and G Idaho, Inc., report provides a review of the submittals for Regulatory Guide 1.97, Revision 2, for the Perry Nuclear Power Plant, Unit Nos. 1 and 2. Any exception to the guidelines of Regulatory Guide 1.97 are evaluated

  17. Conformance to Regulatory Guide 1.97 Slurry Power Station, Unit Nos. 1 and 2 (Docket Nos. 50-280 and 50-281)

    International Nuclear Information System (INIS)

    Stoffel, J.W.

    1985-09-01

    This EG and G Idaho, Inc., report reviews the submittals for Regulatory Guide 1.97, Revision 3, for Unit Nos. 1 and 2 of the Surry Power Station and identifies areas of nonconformance to the regulatory guide. Exceptions to Regulatory Guide 1.97 are evaluated and those areas where sufficient basis for acceptability is not provided are identified

  18. Mediador cultural ou antropólogo do mal: Bruce Albert e o caso de “A queda do céu”

    Directory of Open Access Journals (Sweden)

    Karla Alessandra Alves de Souza Ferreira

    2017-07-01

    Full Text Available Este estudo desenvolve uma análise crítica sobre o fragmento “Postscriptum, quando eu é um outro (e vice-versa”, apresentado na obra A Queda do céu: palavras de um xamã yanomami. O livro foi pensado por um xamã yanomami; Davi Kopenawa, e produzido por um etnólogo francês Bruce Albert. Problematizo o processo de produção do livro onde dois universos culturais se encontram, uma produção literária indígena do povo Yanomami que apresenta uma coautoria. Essa análise busca investigar a postura epistêmica de Bruce Albert como mediador cultural ou “antropólogo do mal” no processo de elaboração do livro, a fim de levantar questionamentos sobre o ato tradutório e suas implicações, destacando os desa os e contribuições apresentadas nesse processo. Nesta direção, esse artigo se fundamenta nos pensamentos da história cultural.

  19. Avaliação nutricional, produção e incidência do mal-do-panamá em bananeira 'Prata-Anã' (AAB adubada com K, no quarto ciclo

    Directory of Open Access Journals (Sweden)

    José Tadeu Alves da Silva

    2013-12-01

    Full Text Available O presente trabalho teve como objetivos estimar a dose de K para obter a máxima eficiência física e econômica, estimar o nível crítico foliar de K e relacionar o equilíbrio nutricional da bananeira 'Prata-Anã' com a incidência de plantas com mal-do-panamá no 4º ciclo. O experimento foi realizado em Latossolo Vermelho-Amarelo (LVA, textura média, na região semiárida do norte de Minas Gerais, Brasil. Os tratamentos consistiram nas aplicações de quatro doses de K (0; 400; 800 e 1.200 kg ha-1 ano de K2O. Estes foram distribuídos em blocos ao acaso, com cinco repetições. A adubação com K promoveu aumento na produção da bananeira no 4º ciclo. A máxima eficiência física (31 Mg ha-1 e a econômica (30,5 Mg ha-1 foram obtidas com as aplicações de 969 e 707 kg ha-1 ano-1 de K2O, respectivamente. Os níveis críticos foliares de K obtidos foram 29,5 e 27,1 g kg-1, para a máxima eficiência física e econômica, respectivamente. O aumento das doses de K proporcionou melhor equilíbrio nutricional à bananeira e reduziu a porcentagem de plantas infestadas com o mal-do-panamá.

  20. A proposal for an evaluation model of pharmaceutical services for malaria Uma proposta de modelo de avaliação para a assistência farmacêutica na malária

    Directory of Open Access Journals (Sweden)

    Claudia Garcia Serpa Osorio-de-Castro

    2009-09-01

    Full Text Available Malaria is a serious public health problem in over 90 countries worldwide. In Brazil the disease is prevalent in the Amazon and the control rationale is based on early diagnosis and treatment. Quality pharmaceutical services are considered a key element for control. A proposal for evaluating pharmaceutical services for malaria is presented here. A theoretical outline composed of a logical model and an indicator framework is discussed and strives to establish a basis for assessment and judgment of the way in which these services are actually delivered. The aim is to contribute to the understanding of pharmaceutical services for malaria and other endemic diseases, complying with the directives of the Brazilian National Medicines Policy.A malária é um grave problema de saúde pública em cerca de 90 países. No Brasil, a Amazônia congrega o maior número de casos. No país, o racional de enfrentamento se baseia em diagnóstico precoce e tratamento. A assistência farmacêutica de qualidade é considerada elemento-chave para o controle da doença. Apresenta-se uma proposta de avaliação da assistência farmacêutica, composta por um modelo lógico e uma grade de indicadores, discutidos de modo a estabelecer uma base de comparação e julgamento da forma na qual os serviços são ofertados. O objetivo é contribuir para o entendimento da assistência farmacêutica na malária e em outras endemias, atendendo às diretrizes da Política Nacional de Medicamentos.

  1. The protein inhibitor of nNOS (PIN/DLC1/LC8) binding does not inhibit the NADPH-dependent heme reduction in nNOS, a key step in NO synthesis

    International Nuclear Information System (INIS)

    Parhad, Swapnil S.; Jaiswal, Deepa; Ray, Krishanu; Mazumdar, Shyamalava

    2016-01-01

    The neuronal nitric oxide synthase (nNOS) is an essential enzyme involved in the synthesis of nitric oxide (NO), a potent neurotransmitter. Although previous studies have indicated that the dynein light chain 1 (DLC1) binding to nNOS could inhibit the NO synthesis, the claim is challenged by contradicting reports. Thus, the mechanism of nNOS regulation remained unclear. nNOS has a heme-bearing, Cytochrome P450 core, and the functional enzyme is a dimer. The electron flow from NADPH to Flavin, and finally to the heme of the paired nNOS subunit within a dimer, is facilitated upon calmodulin (CaM) binding. Here, we show that DLC1 binding to nNOS-CaM complex does not affect the electron transport from the reductase to the oxygenase domain. Therefore, it cannot inhibit the rate of NADPH-dependent heme reduction in nNOS, which results in L-Arginine oxidation. Also, the NO release activity does not decrease with increasing DLC1 concentration in the reaction mix, which further confirmed that DLC1 does not inhibit nNOS activity. These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell. - Highlights: • The effect of interaction of nNOS with DLC1 has been debatable with contradicting reports in literature. • Purified DLC1 has no effect on electron transport between reductase and oxygenase domain of purified nNOS-CaM. • The NO release activity of nNOS was not altered by DLC1, supporting that DLC1 does not inhibit the enzyme. • These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell.

  2. The protein inhibitor of nNOS (PIN/DLC1/LC8) binding does not inhibit the NADPH-dependent heme reduction in nNOS, a key step in NO synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Parhad, Swapnil S. [Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Mumbai 400 005 (India); Jaiswal, Deepa [Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Mumbai 400 005 (India); TIFR Centre for Interdisciplinary Sciences, 21 Brundavan Colony, Narsingi, Hyderabad 500075 (India); Ray, Krishanu, E-mail: krishanu@tifr.res.in [Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Mumbai 400 005 (India); Mazumdar, Shyamalava, E-mail: shyamal@tifr.res.in [Tata Institute of Fundamental Research (TIFR), Homi Bhabha Road, Mumbai 400 005 (India)

    2016-03-25

    The neuronal nitric oxide synthase (nNOS) is an essential enzyme involved in the synthesis of nitric oxide (NO), a potent neurotransmitter. Although previous studies have indicated that the dynein light chain 1 (DLC1) binding to nNOS could inhibit the NO synthesis, the claim is challenged by contradicting reports. Thus, the mechanism of nNOS regulation remained unclear. nNOS has a heme-bearing, Cytochrome P450 core, and the functional enzyme is a dimer. The electron flow from NADPH to Flavin, and finally to the heme of the paired nNOS subunit within a dimer, is facilitated upon calmodulin (CaM) binding. Here, we show that DLC1 binding to nNOS-CaM complex does not affect the electron transport from the reductase to the oxygenase domain. Therefore, it cannot inhibit the rate of NADPH-dependent heme reduction in nNOS, which results in L-Arginine oxidation. Also, the NO release activity does not decrease with increasing DLC1 concentration in the reaction mix, which further confirmed that DLC1 does not inhibit nNOS activity. These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell. - Highlights: • The effect of interaction of nNOS with DLC1 has been debatable with contradicting reports in literature. • Purified DLC1 has no effect on electron transport between reductase and oxygenase domain of purified nNOS-CaM. • The NO release activity of nNOS was not altered by DLC1, supporting that DLC1 does not inhibit the enzyme. • These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell.

  3. Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway

    Energy Technology Data Exchange (ETDEWEB)

    Nagane, Masaki; Yasui, Hironobu; Sakai, Yuri; Yamamori, Tohru [Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818 (Japan); Niwa, Koichi [Laboratory of Biochemistry, Department of Food and Cosmetic Science, Faculty of Bioindustry, Tokyo University of Agriculture, Abashiri 099-2493 (Japan); Hattori, Yuichi [Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194 (Japan); Kondo, Takashi [Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194 (Japan); Inanami, Osamu, E-mail: inanami@vetmed.hokudai.ac.jp [Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818 (Japan)

    2015-01-02

    Highlights: • eNOS activity is increased in BAECs exposed to X-rays. • ATM is involved in this increased eNOS activity. • HSP90 modulates the radiation-induced activation of ATM and eNOS. - Abstract: In this study, the involvement of ataxia telangiectasia mutated (ATM) kinase and heat shock protein 90 (HSP90) in endothelial nitric oxide synthase (eNOS) activation was investigated in X-irradiated bovine aortic endothelial cells. The activity of nitric oxide synthase (NOS) and the phosphorylation of serine 1179 of eNOS (eNOS-Ser1179) were significantly increased in irradiated cells. The radiation-induced increases in NOS activity and eNOS-Ser1179 phosphorylation levels were significantly reduced by treatment with either an ATM inhibitor (Ku-60019) or an HSP90 inhibitor (geldanamycin). Geldanamycin was furthermore found to suppress the radiation-induced phosphorylation of ATM-Ser1181. Our results indicate that the radiation-induced eNOS activation in bovine aortic endothelial cells is regulated by ATM and HSP90.

  4. Outcome after BCG treatment for urinary bladder cancer may be influenced by polymorphisms in the NOS2 and NOS3 genes.

    Science.gov (United States)

    Ryk, Charlotta; Koskela, Lotta Renström; Thiel, Tomas; Wiklund, N Peter; Steineck, Gunnar; Schumacher, Martin C; de Verdier, Petra J

    2015-12-01

    Bacillus Calmette-Guérin (BCG)-treatment is an established treatment for bladder cancer, but its mechanisms of action are not fully understood. High-risk non-muscle invasive bladder-cancer (NMIBC)-patients failing to respond to BCG-treatment have worse prognosis than those undergoing immediate radical cystectomy and identification of patients at risk for BCG-failure is of high priority. Several studies indicate a role for nitric oxide (NO) in the cytotoxic effect that BCG exerts on bladder cancer cells. In this study we investigated whether NO-synthase (NOS)-gene polymorphisms, NOS2-promoter microsatellite (CCTTT)n, and the NOS3-polymorphisms-786T>C (rs2070744) and Glu298Asp (rs1799983), can serve as possible molecular markers for outcome after BCG-treatment for NMIBC. All NMIBC-patients from a well-characterized population based cohort were analyzed (n=88). Polymorphism data were combined with information from 15-years of clinical follow-up. The effect of BCG-treatment on cancer-specific death (CSD), recurrence and progression in patients with varying NOS-genotypes were studied using Cox proportional hazard-models and log rank tests. BCG-treatment resulted in significantly better survival in patients without (Log rank: p=0.006; HR: 0.12, p=0.048), but not in patients with a long version ((CCTTT)n ≧13 repeats) of the NOS2-promoter microsatellite. The NOS3-rs2070744(TT) and rs1799983(GG)-genotypes showed decreased risk for CSD (Log rank(TT): p=0.001; Log rank(GG): p=0.010, HR(GG): 0.16, p=0.030) and progression (Log rank(TT): p<0.001, HR(TT): 0.05, p=0.005; Log rank(GG): p<0.001, HR(GG): 0.10, p=0.003) after BCG-therapy compared to the other genotypes. There was also a reduction in recurrence in BCG-treated patients that was mostly genotype independent. Analysis of combined genotypes identified a subgroup of 30% of the BCG-treated patients that did not benefit from BCG-treatment. Our results suggest that the investigated polymorphisms influence patient response

  5. iNOS-dependent increase in colonic mucus thickness in DSS-colitic rats.

    Directory of Open Access Journals (Sweden)

    Olof Schreiber

    Full Text Available AIM: To investigate colonic mucus thickness in vivo in health and during experimental inflammatory bowel disease. METHODS: Colitis was induced with 5% DSS in drinking water for 8 days prior to experiment, when the descending colonic mucosa of anesthetized rats was studied using intravital microscopy. Mucus thickness was measured with micropipettes attached to a micromanipulator. To assess the contributions of NOS and prostaglandins in the regulation of colonic mucus thickness, the non-selective NOS-inhibitor L-NNA (10 mg/kg bolus followed by 3 mg/kg/h, the selective iNOS-inhibitor L-NIL (10 mg/kg bolus followed by 3 mg/kg/h and the non-selective COX-inhibitor diclofenac (5 mg/kg were administered intravenously prior to experiment. To further investigate the role of iNOS in the regulation of colonic mucus thickness, iNOS -/- mice were used. RESULTS: Colitic rats had a thicker firmly adherent mucus layer following 8 days of DSS treatment than untreated rats (88±2 µm vs 76±1 µm. During induction of colitis, the thickness of the colonic mucus layer initially decreased but was from day 3 significantly thicker than in untreated rats. Diclofenac reduced the mucus thickness similarly in colitic and untreated rats (-16±5 µm vs -14±2 µm. While L-NNA had no effect on colonic mucus thickness in DSS or untreated controls (+3±2 µm vs +3±1 µm, L-NIL reduced the mucus thickness significantly more in colitic rats than in controls (-33±4 µm vs -10±3 µm. The importance of iNOS in regulating the colonic mucus thickness was confirmed in iNOS-/- mice, which had thinner colonic mucus than wild-type mice (35±3 µm vs 50±2 µm, respectively. Furthermore, immunohistochemistry revealed increased levels of iNOS in the colonic surface epithelium following DSS treatment. CONCLUSION: Both prostaglandins and nitric oxide regulate basal colonic mucus thickness. During onset of colitis, the thickness of the mucus layer is initially reduced followed by an iNOS

  6. High BMI levels associate with reduced mRNA expression of IL10 and increased mRNA expression of iNOS (NOS2) in human frontal cortex

    DEFF Research Database (Denmark)

    Lauridsen, J K; Olesen, R H; Vendelbo, J

    2017-01-01

    unknown. Therefore we aim to examine the relationship between BMI and gene expression of central inflammatory markers in the human frontal cortex. Microarray data of 141 neurologically and psychiatrically healthy individuals were obtained through the BrainCloud database. A simple linear regression...... correlated (Plinear regression analyses with BMI, age, sex and race as variables were performed in order to identify potential confounders. In conclusion, increasing BMI could affect the IL10-mediated anti...... analysis was performed with BMI as variable on data on IL10, IL1β, IL6, PTGS2 (COX2) and NOS2 (iNOS). Increasing BMI is associated with a decrease in the mRNA expression of IL10 (P=0.014) and an increase in the expression of NOS2 (iNOS; P=0.040). Expressions of IL10 and NOS2 (iNOS) were negatively...

  7. High BMI levels associate with reduced mRNA expression of IL10 and increased mRNA expression of iNOS (NOS2) in human frontal cortex

    DEFF Research Database (Denmark)

    Lauridsen, J K; Olesen, R H; Vendelbo, J

    2017-01-01

    analysis was performed with BMI as variable on data on IL10, IL1β, IL6, PTGS2 (COX2) and NOS2 (iNOS). Increasing BMI is associated with a decrease in the mRNA expression of IL10 (P=0.014) and an increase in the expression of NOS2 (iNOS; P=0.040). Expressions of IL10 and NOS2 (iNOS) were negatively...... correlated (PIL10 was mostly affected by individuals with BMI ⩾40. Multiple linear regression analyses with BMI, age, sex and race as variables were performed in order to identify potential confounders. In conclusion, increasing BMI could affect the IL10-mediated anti...

  8. TERMOS AMBIENTAIS E SOCIAIS NOS RELATÓRIOS DA ADMINISTRAÇÃO

    Directory of Open Access Journals (Sweden)

    Ilse Maria Beuren

    2012-07-01

    Full Text Available O estudo objetiva verificar a tendência dos termos ambientais e sociais evidenciados nos relatórios da administração de 1997 a 2006 de empresas familiares brasileiras. Realizou-se pesquisa exploratória, com abordagem qualitativa, por meio de pesquisa documental e da técnica de análise de conteúdo nos RA de 1997 a 2006. No universo das 500 maiores empresas listadas na Revista Exame, edição 2006, identificaram-se 21 empresas familiares de capital aberto e de controle acionário brasileiro, mas dessas somente 16 publicaram seu RA nos dez anos considerados. Os resultados mostram que a oscilação na quantidade de páginas dos RA ao longo dos anos apresenta relação com algum evento ocorrido nas empresas. A evidenciação dos termos ambientais está mais relacionada às medidas tomadas para cuidar e preservar o meio ambiente do que aos passivos ambientais. A evidenciação dos termos sociais foi direcionada de maneira equilibrada ao público interno e externo. Conclui-se que há uma tendência nos termos ambientais e sociais evidenciados nos RA de 1997 a 2006 das empresas pesquisadas, ainda que tenham sido incorporados vários termos novos ao longo do período.

  9. Population structure from NOS genes correlates with geographical differences in coronary incidence across Europe.

    Science.gov (United States)

    Carreras-Torres, Robert; Ferran, Albert; Zanetti, Daniela; Esteban, Esther; Varesi, Laurent; Pojskic, Naris; Coia, Valentina; Chaabani, Hassen; Via, Marc; Moral, Pedro

    2016-12-01

    The population analysis of cardiovascular risk and non-risk genetic variation can help to identify adaptive or random demographic processes that shaped coronary incidence variation across geography. In this study, 114 single nucleotide polymorphisms and 17 tandem repeat polymorphisms from Nitric Oxide Synthases (NOS) regions were analyzed in 1686 individuals from 35 populations from Europe, North Africa, and the Middle East. NOS genes encode for key enzymes on nitric oxide availability, which is involved in several cardiovascular processes. These genetic variations were used to test for selection and to infer the population structure of NOS regions. Moreover, we tested whether the variation in the incidence of coronary events and in the levels of classical risk factors in 11 of these European populations could be explained by the population structure estimates. Our results supported, first, the absence of clear signs of selection for NOS genetic variants associated with cardiovascular diseases, and second, the presence of a continuous genetic pattern of variation across European and North African populations without a Mediterranean barrier for gene flow. Finally, population structure estimates from NOS regions are closely correlated with coronary event rates and classical risk parameters (explaining 39-98%) among European populations. Our results reinforce the hypothesis that genetic bases of cardiovascular diseases and associated complex phenotypes could be geographically shaped by random demographic processes. © 2016 Wiley Periodicals, Inc.

  10. Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma.

    Science.gov (United States)

    Morelatto, Rosana; Itoiz, María-Elina; Guiñazú, Natalia; Piccini, Daniel; Gea, Susana; López-de Blanc, Silvia

    2014-05-01

    The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcinomas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were analyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by immunohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative (p=0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes.

  11. Expression of leptin and iNOS in oral melanomas in dogs.

    Science.gov (United States)

    Greene, V R; Wilson, H; Pfent, C; Roethele, J; Carwile, J; Qin, Y; Grimm, E; Ellerhorst, J A

    2013-01-01

    Oral melanoma (OM) in dogs is an aggressive malignancy, with clinical behavior resembling cutaneous melanomas in humans. Melanoma in humans is promoted by an inflammatory environment that is contributed to by leptin and inducible nitric oxide synthase (iNOS). To determine if the patterns of leptin and iNOS expression are similar in OM in dogs and cutaneous melanomas in humans. Twenty client-owned dogs. Retrospective case study. Immunostaining of the OM tumors from each dog was scored for percentage and intensity of leptin and iNOS expression. Mitotic index was used as an indicator of tumor aggression. Leptin was detected in ≥75% of the tumor cells in specimens from 11 dogs. One tumor expressed leptin in ≤25% of the cells. The intensity of leptin expression was variable with 6, 9, and 5 cases exhibiting low-, moderate-, and high-intensity staining, respectively. OM with the lowest percentage of iNOS positive cells displayed the highest mitotic indices (P = .006, ANOVA). The expression of leptin is a common finding in melanomas in dogs. These data suggest that the possibility of future clinical applications, such as measuring the concentrations of plasma leptin as a screening tool or leptin as a target for therapy. The relevance of iNOS is not as clear in dogs with OM, for which other directed therapeutics might be more appropriate. Copyright © 2013 by the American College of Veterinary Internal Medicine.

  12. Assessing depression outcome in patients with moderate dementia: sensitivity of the HoNOS65+ scale.

    Science.gov (United States)

    Canuto, Alessandra; Rudhard-Thomazic, Valérie; Herrmann, François R; Delaloye, Christophe; Giannakopoulos, Panteleimon; Weber, Kerstin

    2009-08-15

    To date, there is no widely accepted clinical scale to monitor the evolution of depressive symptoms in demented patients. We assessed the sensitivity to treatment of a validated French version of the Health of the Nation Outcome Scale (HoNOS) 65+ compared to five routinely used scales. Thirty elderly inpatients with ICD-10 diagnosis of dementia and depression were evaluated at admission and discharge using paired t-test. Using the Brief Psychiatric Rating Scale (BPRS) "depressive mood" item as gold standard, a receiver operating characteristic curve (ROC) analysis assessed the validity of HoNOS65+F "depressive symptoms" item score changes. Unlike Geriatric Depression Scale, Mini Mental State Examination and Activities of Daily Living scores, BPRS scores decreased and Global Assessment Functioning Scale score increased significantly from admission to discharge. Amongst HoNOS65+F items, "behavioural disturbance", "depressive symptoms", "activities of daily life" and "drug management" items showed highly significant changes between the first and last day of hospitalization. The ROC analysis revealed that changes in the HoNOS65+F "depressive symptoms" item correctly classified 93% of the cases with good sensitivity (0.95) and specificity (0.88) values. These data suggest that the HoNOS65+F "depressive symptoms" item may provide a valid assessment of the evolution of depressive symptoms in demented patients.

  13. iNOS Activity Modulates Inflammation, Angiogenesis, and Tissue Fibrosis in Polyether-Polyurethane Synthetic Implants

    Science.gov (United States)

    Cassini-Vieira, Puebla; Araújo, Fernanda Assis; da Costa Dias, Filipi Leles; Russo, Remo Castro; Andrade, Silvia Passos; Teixeira, Mauro Martins; Barcelos, Luciola Silva

    2015-01-01

    There is considerable interest in implantation techniques and scaffolds for tissue engineering and, for safety and biocompatibility reasons, inflammation, angiogenesis, and fibrosis need to be determined. The contribution of inducible nitric oxide synthase (iNOS) in the regulation of the foreign body reaction induced by subcutaneous implantation of a synthetic matrix was never investigated. Here, we examined the role of iNOS in angiogenesis, inflammation, and collagen deposition induced by polyether-polyurethane synthetic implants, using mice with targeted disruption of the iNOS gene (iNOS−/−) and wild-type (WT) mice. The hemoglobin content and number of vessels were decreased in the implants of iNOS−/− mice compared to WT mice 14 days after implantation. VEGF levels were also reduced in the implants of iNOS−/− mice. In contrast, the iNOS−/− implants exhibited an increased neutrophil and macrophage infiltration. However, no alterations were observed in levels of CXCL1 and CCL2, chemokines related to neutrophil and macrophage migration, respectively. Furthermore, the implants of iNOS−/− mice showed boosted collagen deposition. These data suggest that iNOS activity controls inflammation, angiogenesis, and fibrogenesis in polyether-polyurethane synthetic implants and that lack of iNOS expression increases foreign body reaction to implants in mice. PMID:26106257

  14. Modulation of liver mitochondrial NOS is implicated in thyroid-dependent regulation of O(2) uptake.

    Science.gov (United States)

    Carreras, M C; Peralta, J G; Converso, D P; Finocchietto, P V; Rebagliati, I; Zaninovich, A A; Poderoso, J J

    2001-12-01

    Changes in O(2) uptake at different thyroid status have been explained on the basis of the modulation of mitochondrial enzymes and membrane biophysical properties. Regarding the nitric oxide (NO) effects, we tested whether liver mitochondrial nitric oxide synthase (mtNOS) participates in the modulation of O(2) uptake in thyroid disorders. Wistar rats were inoculated with 400 microCi (131)I (hypothyroid group), 20 microg thyroxine (T(4))/100 g body wt administered daily for 2 wk (hyperthyroid group) or vehicle (control). Basal metabolic rate, mitochondrial function, and mtNOS activity were analyzed. Systemic and liver mitochondrial O(2) uptake and cytochrome oxidase activity were lower in hypothyroid rats with respect to controls; mitochondrial parameters were further decreased by L-arginine (-42 and -34%, P activity (260%) were selectively increased in hypothyroidism and reverted by hormone replacement without changes in other nitric oxide isoforms. Moreover, mtNOS activity correlated with serum 3,5,3'-triiodothyronine (T(3)) and O(2) uptake. Increased mtNOS activity was also observed in skeletal muscle mitochondria from hypothyroid rats. Therefore, we suggest that modulation of mtNOS is a substantial part of thyroid effects on mitochondrial O(2) uptake.

  15. The protein inhibitor of nNOS (PIN/DLC1/LC8) binding does not inhibit the NADPH-dependent heme reduction in nNOS, a key step in NO synthesis.

    Science.gov (United States)

    Parhad, Swapnil S; Jaiswal, Deepa; Ray, Krishanu; Mazumdar, Shyamalava

    2016-03-25

    The neuronal nitric oxide synthase (nNOS) is an essential enzyme involved in the synthesis of nitric oxide (NO), a potent neurotransmitter. Although previous studies have indicated that the dynein light chain 1 (DLC1) binding to nNOS could inhibit the NO synthesis, the claim is challenged by contradicting reports. Thus, the mechanism of nNOS regulation remained unclear. nNOS has a heme-bearing, Cytochrome P450 core, and the functional enzyme is a dimer. The electron flow from NADPH to Flavin, and finally to the heme of the paired nNOS subunit within a dimer, is facilitated upon calmodulin (CaM) binding. Here, we show that DLC1 binding to nNOS-CaM complex does not affect the electron transport from the reductase to the oxygenase domain. Therefore, it cannot inhibit the rate of NADPH-dependent heme reduction in nNOS, which results in l-Arginine oxidation. Also, the NO release activity does not decrease with increasing DLC1 concentration in the reaction mix, which further confirmed that DLC1 does not inhibit nNOS activity. These findings suggest that the DLC1 binding may have other implications for the nNOS function in the cell. Copyright © 2016 Elsevier Inc. All rights reserved.

  16. Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.

    Science.gov (United States)

    Cerqueira, Fernanda M; Laurindo, Francisco R M; Kowaltowski, Alicia J

    2011-03-31

    Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR). Since treatment of mice with dinitrophenol (DNP) promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis.

  17. Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.

    Directory of Open Access Journals (Sweden)

    Fernanda M Cerqueira

    2011-03-01

    Full Text Available Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR. Since treatment of mice with dinitrophenol (DNP promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis.

  18. Fluxo do transporte de suínos para abate no Estado de Mato Grosso

    OpenAIRE

    Pereira,Thuanny Lúcia; Corassa,Anderson

    2014-01-01

    Objetivou-se descrever o fluxo de suínos para abate produzidos no Estado de Mato Grosso entre os anos de 2008 e 2012. Foram utilizados dados de 9.426.729 suínos produzidos no Estado de Mato Grosso e transportados para abate de janeiro de 2008 a dezembro de 2012, no qual realizou-se análise descritiva das informações, com frequências de origem e destino; machos e fêmeas em função dos meses e anos e as distâncias percorridas. Observou-se crescimento no número de viagens e de suínos transportado...

  19. Synthesis of a Potent Aminopyridine-Based nNOS-Inhibitor by Two Recent No-Carrier-Added $^{18}$F-Labelling Methods

    OpenAIRE

    Drerup, Christian; Ermert, Johannes; Coenen, Heinrich Hubert

    2016-01-01

    Nitric oxide (NO), an important multifunctional signaling molecule, is produced by three isoforms of NO-synthase (NOS) and has been associated with neurodegenerative disorders. Selective inhibitors of the subtypes iNOS (inducible) or nNOS (neuronal) are of great interest for decoding neurodestructive key factors, and 18F-labelled analogues would allow investigating the NOS-function by molecular imaging with positron emission tomography. Especially, the highly selective nNOS inhibitor 6-((3-((...

  20. Effects of Paracetamol on NOS, COX, and CYP Activity and on Oxidative Stress in Healthy Male Subjects, Rat Hepatocytes, and Recombinant NOS

    Science.gov (United States)

    Trettin, Arne; Böhmer, Anke; Suchy, Maria-Theresia; Probst, Irmelin; Staerk, Ulrich; Stichtenoth, Dirk O.; Frölich, Jürgen C.

    2014-01-01

    Paracetamol (acetaminophen) is a widely used analgesic drug. It interacts with various enzyme families including cytochrome P450 (CYP), cyclooxygenase (COX), and nitric oxide synthase (NOS), and this interplay may produce reactive oxygen species (ROS). We investigated the effects of paracetamol on prostacyclin, thromboxane, nitric oxide (NO), and oxidative stress in four male subjects who received a single 3 g oral dose of paracetamol. Thromboxane and prostacyclin synthesis was assessed by measuring their major urinary metabolites 2,3-dinor-thromboxane B2 and 2,3-dinor-6-ketoprostaglandin F1α, respectively. Endothelial NO synthesis was assessed by measuring nitrite in plasma. Urinary 15(S)-8-iso-prostaglanding F2α was measured to assess oxidative stress. Plasma oleic acid oxide (cis-EpOA) was measured as a marker of cytochrome P450 activity. Upon paracetamol administration, prostacyclin synthesis was strongly inhibited, while NO synthesis increased and thromboxane synthesis remained almost unchanged. Paracetamol may shift the COX-dependent vasodilatation/vasoconstriction balance at the cost of vasodilatation. This effect may be antagonized by increasing endothelial NO synthesis. High-dosed paracetamol did not increase oxidative stress. At pharmacologically relevant concentrations, paracetamol did not affect NO synthesis/bioavailability by recombinant human endothelial NOS or inducible NOS in rat hepatocytes. We conclude that paracetamol does not increase oxidative stress in humans. PMID:24799980

  1. Religião e patriotismo: o anticomunismo católico nos Estados Unidos e no Brasil nos anos da Guerra Fria

    Directory of Open Access Journals (Sweden)

    Carla Simone Rodeghero

    2002-01-01

    Full Text Available O artigo analisa e compara o anticomunismo católico no Brasil e nos Estados Unidos no período da Guerra Fria. Depois de situar o campo de estudos constituído no Brasil sobre o tema, discute as relações entre americanismo e anticomunismo, procurando situar o catolicismo norte-americano neste meio. Utiliza-se de uma produção recente sobre cultura da Guerra Fria nos Estados Unidos. Levanta, finalmente, uma série de elementos de comparação sobre a forma que o anticomunismo católico assumiu nos dois países.This article analyses and compares the Catholic anticommunism in the Brazil and in United States during the Cold War years. After showing the recent studies produced in Brazil about the fight against communism, it discusses the relationship between Americanism, anticommunism and Catholicism. This step is based on recent historical research about the Cold War culture in the United States. Finally, it makes comparisons between the forms that anticommunism assumed in each country.

  2. Intoxicação experimental de suínos por fumonisinas

    Directory of Open Access Journals (Sweden)

    Dilkin Paulo

    2004-01-01

    Full Text Available Os efeitos da exposição oral prolongada (28 dias à fumonisina foram estudados em suínos jovens. Os animais foram divididos em três grupos experimentais e alimentados com ração ad libitum contendo: A 0mg de FB1.kg-1 (controle; B 10mg de FB1.kg-1; C 30mg de FB1.kg-1. Os suínos foram observados duas vezes por dia; seus pesos e consumo alimentar foram registrados semanalmente. Entre o 20º e 24º dia de intoxicação, os suínos do tratamentos C apresentaram diminuição do consumo de ração e ganho de peso, sinais característicos de edema pulmonar, razão pela qual um animal foi levado a óbito aos 23 dias de intoxicação. Após 28 dias, os animais foram necropsiados e os órgãos submetidos a análises macroscópica, histopatológica e ao estudo da morfologia e histologia intestinal. Nos suínos que apresentaram sinais clínicos de intoxicação, observaram-se lesões pulmonares, hepáticas e diminuição de altura das vilosidades e profundidade das criptas e hiperplasia glandular em segmentos intestinais. Conclui-se, portanto, que substanciais perdas de produtividade podem ser induzidas em suínos alimentados com ração contaminada com baixos níveis de fumonisinas.

  3. Inducible nitric oxide synthase (iNOS) regulatory region variation in non-human primates.

    Science.gov (United States)

    Roodgar, Morteza; Ross, Cody T; Kenyon, Nicholas J; Marcelino, Gretchen; Smith, David Glenn

    2015-04-01

    Inducible nitric oxide synthase (iNOS) is an enzyme that plays a key role in intracellular immune response against respiratory infections. Since various species of nonhuman primates exhibit different levels of susceptibility to infectious respiratory diseases, and since variation in regulatory regions of genes is thought to play a key role in expression levels of genes, two candidate regulatory regions of iNOS were mapped, sequenced, and compared across five species of nonhuman primates: African green monkeys (Chlorocebus sabaeus), pig-tailed macaques (Macaca nemestrina), cynomolgus macaques (Macaca fascicularis), Indian rhesus macaques (Macaca mulatta), and Chinese rhesus macaques (M. mulatta). In addition, we conducted an in silico analysis of the transcription factor binding sites associated with genetic variation in these two candidate regulatory regions across species. We found that only one of the two candidate regions showed strong evidence of involvement in iNOS regulation. Specifically, we found evidence of 13 conserved binding site candidates linked to iNOS regulation: AP-1, C/EBPB, CREB, GATA-1, GATA-3, NF-AT, NF-AT5, NF-κB, KLF4, Oct-1, PEA3, SMAD3, and TCF11. Additionally, we found evidence of interspecies variation in binding sites for several regulatory elements linked to iNOS (GATA-3, GATA-4, KLF6, SRF, STAT-1, STAT-3, OLF-1 and HIF-1) across species, especially in African green monkeys relative to other species. Given the key role of iNOS in respiratory immune response, the findings of this study might help guide the direction of future studies aimed to uncover the molecular mechanisms underlying the increased susceptibility of African green monkeys to several viral and bacterial respiratory infections. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. A vast amount of various invariant tori in the Nosé-Hoover oscillator.

    Science.gov (United States)

    Wang, Lei; Yang, Xiao-Song

    2015-12-01

    This letter restudies the Nosé-Hoover oscillator. Some new averagely conservative regions are found, each of which is filled with different sequences of nested tori with various knot types. Especially, the dynamical behaviors near the border of "chaotic region" and conservative regions are studied showing that there exist more complicated and thinner invariant tori around the boundaries of conservative regions bounded by tori. Our results suggest an infinite number of island chains in a "chaotic sea" for the Nosé-Hoover oscillator.

  5. A vast amount of various invariant tori in the Nosé-Hoover oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Lei [School of Mathematics and Statistics, Huazhong University of Science and Technology, Wuhan 430074 (China); Department of Mathematics and Physics, Hefei University, Hefei 230601 (China); Yang, Xiao-Song, E-mail: yangxs@hust.edu.cn [School of Mathematics and Statistics, Huazhong University of Science and Technology, Wuhan 430074 (China)

    2015-12-15

    This letter restudies the Nosé-Hoover oscillator. Some new averagely conservative regions are found, each of which is filled with different sequences of nested tori with various knot types. Especially, the dynamical behaviors near the border of “chaotic region” and conservative regions are studied showing that there exist more complicated and thinner invariant tori around the boundaries of conservative regions bounded by tori. Our results suggest an infinite number of island chains in a “chaotic sea” for the Nosé-Hoover oscillator.

  6. A vast amount of various invariant tori in the Nosé-Hoover oscillator

    Science.gov (United States)

    Wang, Lei; Yang, Xiao-Song

    2015-12-01

    This letter restudies the Nosé-Hoover oscillator. Some new averagely conservative regions are found, each of which is filled with different sequences of nested tori with various knot types. Especially, the dynamical behaviors near the border of "chaotic region" and conservative regions are studied showing that there exist more complicated and thinner invariant tori around the boundaries of conservative regions bounded by tori. Our results suggest an infinite number of island chains in a "chaotic sea" for the Nosé-Hoover oscillator.

  7. Circulating NOS3 modulates left ventricular remodeling following reperfused myocardial infarction.

    Directory of Open Access Journals (Sweden)

    Simone Gorressen

    Full Text Available Nitric oxide (NO is constitutively produced and released from the endothelium and several blood cell types by the isoform 3 of the NO synthase (NOS3. We have shown that NO protects against myocardial ischemia/reperfusion (I/R injury and that depletion of circulating NOS3 increases within 24 h of ischemia/reperfusion the size of myocardial infarction (MI in chimeric mice devoid of circulating NOS3. In the current study we hypothesized that circulating NOS3 also affects remodeling of the left ventricle following reperfused MI.To analyze the role of circulating NOS3 we transplanted bone marrow of NOS3-/- and wild type (WT mice into WT mice, producing chimerae expressing NOS3 only in vascular endothelium (BC-/EC+ or in both, blood cells and vascular endothelium (BC+/EC+. Both groups underwent 60 min of coronary occlusion in a closed-chest model of reperfused MI. During the 3 weeks post MI, structural and functional LV remodeling was serially assessed (24 h, 4 d, 1 w, 2 w and 3 w by echocardiography. At 72 hours post MI, gene expression of several extracellular matrix (ECM modifying molecules was determined by quantitative RT-PCR analysis. At 3 weeks post MI, hemodynamics were obtained by pressure catheter, scar size and collagen content were quantified post mortem by Gomori's One-step trichrome staining.Three weeks post MI, LV end-systolic (53.2±5.9 μl; ***p≤0.001; n = 5 and end-diastolic volumes (82.7±5.6 μl; *p<0.05; n = 5 were significantly increased in BC-/EC+, along with decreased LV developed pressure (67.5±1.8 mm Hg; n = 18; ***p≤0.001 and increased scar size/left ventricle (19.5±1.5%; n = 13; **p≤0.01 compared to BC+/EC+ (ESV: 35.6±2.2 μl; EDV: 69.1±2.6 μl n = 8; LVDP: 83.2±3.2 mm Hg; n = 24; scar size/LV13.8±0.7%; n = 16. Myocardial scar of BC-/EC+ was characterized by increased total collagen content (20.2±0.8%; n = 13; ***p≤0.001 compared to BC+/EC+ (15.9±0.5; n = 16, and increased collagen type I and III subtypes

  8. Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain.

    Science.gov (United States)

    Cattano, D; Valleggi, S; Abramo, A; Forfori, F; Maze, M; Giunta, F

    2010-06-01

    Animal studies suggest that neuronal cell death often results from anesthetic administration during synaptogenesis. Volatile anesthetics are strongly involved in triggering neuronal apoptosis, whereas other inhalational agents (xenon) demonstrate protective effects. Nitrous oxide (N2O) has modest pro-apoptotic effects on its own and potent, synergistic toxic effects when combined with volatile agents. Recent findings suggest that, during periods of rapid brain development, the enhanced neurodegeneration triggered by anesthetic drugs may be caused by a compensatory increase in intracellular free calcium, a potent activator of neuronal nitric oxide synthase (nNOS). Anesthesia-induced neuro-apoptosis is also activated via the intrinsic and the extrinsic apoptotic pathways because both pathways involve p53, a key regulatory gene. The molecular events related to neuronal cell apoptosis are not completely understood. To gain further insight into the events underlying neuro-apoptosis, we analyzed the transcriptional consequences of N2O exposure on nNOS, iNOS and p53 mRNA levels. The study used 2 groups of postnatal day seven Sprague/Dawley rats (N=6 each) that were exposed for 120 minutes to air (75% N2, 25% O2) or N2O (75% N2O, 25% O2; this N2O concentration is commonly used to induce anesthesia and has been demonstrated to trigger neurodegeneration in postnatal day seven rats). Total RNA was isolated from each brain and expression analyses on iNOS and nNOS transcripts were performed using relative Real-Time C-reactive protein PCR (using G3PDH as a housekeeping gene). A semi-quantitative RT-PCR analysis was performed on the p53 transcript (using Ciclophylin A as a housekeeping gene). Statistical analysis (REST 2005) revealed a significant, 11-fold up-regulation (P=0.026) of the nNOS transcript but no significant changes in iNOS transcription. The p53 mRNA was up-regulated almost 2-fold (P=0.0002; Student's t-Test; GraphPad Prism 4.00) in N2O-treated samples relative to

  9. O papel de imunoglobulinas na nefropatia da leptospirose em suínos

    Directory of Open Access Journals (Sweden)

    Larissa M.F. Gonçalves

    2014-06-01

    Full Text Available A leptospirose é uma antropozoonose endêmica em todo o mundo, que afeta o homem e várias espécies de animais domésticos e silvestres. No início da infecção há produção de IgM para o controle da infecção e após alguns dias, IgG são produzidas e provocam lise das leptospiras circulantes. Objetivou-se neste estudo identificar depósitos de antígeno de leptospiras e imunoglobulinas no tecido renal, para avaliar o papel de imunoglobulinas na patogênese da nefropatia da leptospirose em suínos. Foram colhidas 139 amostras de sangue e rim de suínos das cidades de Teresina/PI e Timon/MA, que foram avaliadas pela SAM, imunoistoquímica e PCR. Nefrite intersticial, fibrose, vasculite, tumefação do tufo glomerular e hipercelularidade difusa foram as principais alterações histopatológicas encontradas. A imunoistoquímica detectou antígeno de leptospira em 60 suínos. Depósitos de IgG, IgM e IgA foram observados no endotélio de capilares glomerulares, dos capilares intertubulares e na cápsula de Bowman, com marcação focal, difusa, global e segmentar. A deposição de IgM e IgA foi significantemente maior nos suínos infectados. Estranhamente depósitos de IgG foi significantemente maior nos suínos não infectados, onde não havia presença de antígeno de leptospiras e nem lesão túbulo-intersticial. Concluímos que antígeno de leptospiras no rim de suínos está relacionado a depósitos de IgM e IgA mas não a depósitos de IgG.

  10. Associação de eventos de vida produtores de estresse e mal-estar psicológico: um estudo de base populacional Association of stressful life events and psychological distress: a community-based study

    Directory of Open Access Journals (Sweden)

    Felipe Sparrenberger

    2004-02-01

    Full Text Available Foi realizado, em 1999, estudo transversal para investigar a associação entre determinados eventos produtores de estresse e a sensação de mal-estar psicológico. A Escala de Faces foi usada para medir o desfecho. A ocorrência de morte e doença em familiar, separação conjugal, roubo, acidente, migração e perda do emprego no ano anterior à entrevista, foi investigada entre 3.942 pessoas maiores de vinte anos de idade. A análise por regressão logística seguiu modelo hierárquico incluindo, no primeiro nível, características sócio-demográficas individuais; no segundo, eventos estressantes e, no terceiro, o mal-estar psicológico. Acidente e migração não se associaram ao desfecho. O maior efeito foi para separação conjugal (OR ajustada de 2,34. Os mais altos riscos atribuíveis na população foram os das variáveis sócio-econômicas (escolaridade 38,2% e renda 32,3% e o da ocorrência de pelo menos um dos eventos (36,4%. Atuação no plano das políticas públicas, visando a reduzir a ocorrência de eventos sociais negativos e, no plano individual, auxiliando as pessoas a lidar melhor com estes fatos da vida, poderiam contribuir para reduzir substancialmente a sensação de mal-estar psicológico.A cross-sectional study was conducted in 1999 to investigate the association between stressful psychosocial events and psychological distress. A Faces Scale was used to measure the outcome. Death and illness in the family, divorce, robbery, injury, migration, and loss of employment in the previous year were investigated through interviews with 3,942 individuals over 20 years. Logistic regression followed a hierarchical model using socio-demographic characteristics at the first level; psychosocial events at the second; and psychological distress at the third. Injury and migration were not associated with the outcome. The strongest effect was associated with divorce (adjusted OR = 2.34. The highest population-attributable risks were

  11. Instituição da Suspensão Condicional do Processo nos Casos de Violência Doméstica Contra a Mulher a Partir da Alteração da Lei Maria Da Penha: Por uma Alternativa Menos Rigorosa Baseada na Conciliação para Enfrentar esse Mal

    OpenAIRE

    Carvalho, Márcia Haydée Porto de

    2016-01-01

    Estuda-se a suspensão condicional do processo penal, instituto em que consiste na suspensão do curso processual, por ordem judicial, por certo período de tempo, desde que o acusado aceite, com a concordância de seu advogado, cumprir algumas condições, em face de proposta do Ministério Público, uma vez presentes os requisitos exigidos em lei, sendo que, após terminado o período de prova sem revogação do benefício, o processo é arquivado. A aplicação do referido instituto foi proibida pelo Supr...

  12. Holocenní profil ve stavební jámě malé vodní elektrárny Hýskov a jeho přínos k poznání nivy Berounky

    Czech Academy of Sciences Publication Activity Database

    Žák, Karel; Cílek, Václav; Danielisová, Alžběta; Hlaváč, Jaroslav; Kadlec, Jaroslav; Kyncl, T.; Pokorný, Petr; Světlík, Ivo

    2010-01-01

    Roč. 36, - (2010), s. 42-51 ISSN 1211-1643 R&D Projects: GA AV ČR IAAX00020701 Institutional research plan: CEZ:AV0Z30130516; CEZ:AV0Z80020508; CEZ:AV0Z10480505 Keywords : Holocene * Berounka River * floodplain Subject RIV: DO - Wilderness Conservation

  13. Preliminary data from {gamma}-cardiography during the abatement of an asthmatic attack (1961); Premieres donnees de la {gamma}-cardiographie au decours de l'etat de mal asthmatique (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Georges, R; Vernejoul, P de; Raynaud, C; Blanchon, P; Kellershohn, C; Turiaf, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-07-01

    The authors used gamma cardiology during the abatement of 16 cases of asthma with a view to detecting heart attacks not otherwise visible with routine methods of examination: clinical, radiological and electro-cardio-graphical. In gamma cardiology, a radioactive indicator is used and its path followed in the cavities of the heart. The method makes it possible to study the circulation in the right heart, the pulmonary crossing, and the left heart, as well as evaluation of the heart-flow. As a result of their investigations the authors, after having discussed the significance of the data obtained with the method, suggest that it is possible by the use of gamma cardiography during the abatement of an asthma attack: 1- To confirm attacks of the right heart which have already been detected by ordinary methods. 2- To confirm the presence of modifications in the recorded curves which suggest, in the case of the left heart, possible attack; such on attack is also indicated, in a small number of cases, by electrocardiography curves. Some considerations are put forward by the authors concerning the physiopathology of attacks on the left heart. (authors) [French] Les auteurs ont fait appel a la gammacardiographie au decours de 16 cas d'etat de mal asthmatique, dans le but d'objectiver des atteintes cardiaques incapables d'etre revelees par les moyens d'exploration de routine: cliniques, radiologiques et electrocardiographiques. La gammacardiographie est un procede qui enregistre a l'aide d'un indicateur radioactif, le trajet de celui-ci dans les cavites cardiaques. Elle permet l'etude de la circulation dans le coeur droit, de la traversee pulmonaire, et le coeur gauche, de meme que le calcul du debit cardiaque. Au terme de leurs investigations, les auteurs apres avoir discute la signification des donnees fournies par la methode admettent que la gammacardiographie objective au secours de l'etat de mal asthmatique: 1- La confirmation de l'atteinte du coeur droit deja etablie

  14. Participação política e juventude: do mal-estar à responsabilização frente ao destino comum

    Directory of Open Access Journals (Sweden)

    Lúcia Rabello de Castro

    2008-06-01

    Full Text Available O artigo analisa a relação entre juventude e política no contemporâneo, tendo como foco de discussão o processo de subjetivação política, que implica a construção do pertencimento à coletividade e a responsabilização pela vida em comum. As possibilidades de ação engajada e seu sentido político são discutidos frente às aparentes inércia e apatia dos jovens de hoje em relação à política. Um estudo empírico qualitativo com cerca de 25 jovens é apresentado, baseado em entrevistas realizadas tanto com jovens militantes de organizações estudantis e partidos políticos como com aqueles que se engajam no trabalho social voluntário. Na análise, evidenciam-se convergências e divergências entre os dois grupos nos sentidos e objetivos da ação engajada e das formas convencionais de militância. Discutem-se as relações entre as trajetórias desses jovens e o abraçamento de determinadas "causas" que os mobilizam para a ação e a participação na sociedade. Os dois grupos relatam impasses e dificuldades inerentes às escolhas de seus modos de agir e participar: seja por força de buscarem uma eficácia da ação e evitar seus percalços ao submetê-la ao enquadramento da política institucionalizada; seja por força das concessões que se vêem fazendo aos princípios e ideais partidários, distanciando a ação de seu fundamento. Tais dificuldades remetem à distinção entre a política e o político, tendo em vista que a forma institucionalizada de fazer política hoje parece não dar mais conta das demandas da vida em comum; por outro lado, as novas formas de participação política podem insular-se nas ações pontuais. Conclui-se que, para os jovens entrevistados, as formas de participação e de engajamento social enveredam por caminhos diversos, sejam os da política institucional, sejam os da ação militante no trabalho social voluntário; embora o sentido político das ações nem sempre seja explicitamente

  15. Qualidade de vida no trabalho: controle e escondimento do mal-estar do trabalhador Quality of work life: control and concealment of worker discontent

    Directory of Open Access Journals (Sweden)

    José Newton Garcia de Araújo

    2009-11-01

    Full Text Available Este texto tenta fazer eco à desconstrução dos programas de QVT, na ótica do artigo da professora Valquíria Padilha. O ponto de partida são as considerações de Castoriadis (1997, relativas à 'racionalidade' do capitalismo que, fundada na conformidade entre meios e fins, não se interroga sobre a própria racionalidade desses fins, supostamente inquestionáveis. Relembra-se também aqui a atualidade das análises de Marx sobre o modo de produção capitalista e seu sistema de trocas, fundado na mais-valia e que faz da alienação a essência do trabalho. Tal modo de produção continua sendo uma fonte permanente de acidentes, doenças e mortes no trabalho, fazendo milhões de vítimas, anualmente, em todo o planeta. As relações entre capital e trabalho se traduzem em um conflito inconciliável, que os ideólogos da gestão de recursos humanos tentam, no entanto, 'desconhecer' ou ocultar. As sucessivas inovações tecnológicas estão orientadas, segundo Castoriadis, para a redução e posterior eliminação do homem, nos processos de produção, embora isso só seja parcialmente possível. Assim sendo, a 'racionalidade' da gestão dos recursos humanos deve recorrer a sucessivas estratégias de manipulação-sedução do trabalhador, através dos recorrentes modismos gerenciais, entre os quais se inserem os programas de QVT.This text tries to echo the deconstruction of the programs of Quality of work life (QWL, from the perspective of the article by Valkyrie Padilha. We start with Castoriadis' (1997 considerations on the 'rationality' of capitalism which, based on the conformity between means and ends, does not question itself about the very rationale of these supposedly unquestionable ends. It also highlights the currentness of Marx's analyses on the capitalist mode of production and its exchange system, based on surplus value and that turns alienation into the essence of work. This mode of production remains a constant source of

  16. Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em recém-nascidos de grávidas com malária, na Colômbia Intrauterine growth retardation, low birth weight and prematurity in neonates of pregnant women with malaria in Colombia

    Directory of Open Access Journals (Sweden)

    Alberto Tobón-Castaño

    2011-06-01

    Full Text Available INTRODUÇÃO: É frequente a associação da malária com complicações como prematuridade, retardo no crescimento intrauterino, baixo peso ao nascer e mortalidade infantil, efeitos pouco estudados em áreas hipoendêmicas para malaria. O objetivo deste estudo foi analisar a relação da malária gestacional com estes efeitos em recém-nascidosnuma região endêmica para malária na Colômbia, entre 1993 e 2007. MÉTODOS: Foram estudadas as características em 1.716 recém-nascidos num estudo de coorte. Fez-se seguimento em 394 gestantes com malária (27% por Plasmodium falciparum e 73% por P. vivax e 1.322 sem malária. RESULTADOS: Foi encontrada uma relação entre a exposição à malária na gestação e o risco maior de baixo peso ao nascer (RR = 1,37; 1,03-1,83, assim como estatura baixa (RR = 1,52; 1,25-1,85, retardo no crescimento intrauterino (RR = 1,29; 1,0-1,66 e prematuridade (RR = 1,68; 1,3-2,17. A frequência de nascimentos prematuros foi maior nas mães com malária por P. falciparum (77% que aquelas com P. vivax (RR = 1,77; IC 95%: 1,2-2,6. CONCLUSÕES: O baixo peso ao nascer e o retardo no crescimento foi associado com malária na gestação na Colômbia. A infecção por P. vivax foi relacionada com efeitos adversos sobre o recém-nascido, de modo semelhante em relação ao P. falciparum.INTRODUCTION: Association between malaria and pregnancy complications, such as prematurity, intrauterine growth restriction, low birthweight and infant mortality has been reported. These effects have been studied widely in areas hyperendemic for malaria, but studies in low-endemic areas are scarce. The study investigated the relation between gestational malaria and low birthweight and intrauterine growth retardation in neonates of a malarial endemic region in Colombia, between 1993 and 2007. METHODS: The pattern of development in 1,716 neonates of women with and without malaria infection during pregnancy was evaluated in a cohort study. A

  17. ICoNOs MM: The IT-enabled Collaborative Networked Organizations Maturity Model

    NARCIS (Netherlands)

    Santana Tapia, R.G.

    2009-01-01

    The focus of this paper is to introduce a comprehensive model for assessing and improving maturity of business-IT alignment (B-ITa) in collaborative networked organizations (CNOs): the ICoNOs MM. This two dimensional maturity model (MM) addresses five levels of maturity as well as four domains to

  18. Resting Tension Affects eNOS Activity in a Calcium-Dependent Way in Airways

    Directory of Open Access Journals (Sweden)

    Paschalis-Adam Molyvdas

    2007-03-01

    Full Text Available The alteration of resting tension (RT from 0.5 g to 2.5 g increased significantly airway smooth muscle contractions induced by acetylcholine (ACh in rabbit trachea. The decrease in extracellular calcium concentration [Ca2+]o from 2 mM to 0.2 mM reduced ACh-induced contractions only at 2.5 g RT with no effect at 0.5 g RT. The nonselective inhibitor of nitric oxide synthase (NOS, NG-nitro-L-arginine methyl ester (L-NAME increased ACh-induced contractions at 2.5 g RT. The inhibitor of inducible NOS, S-methylsothiourea or neuronal NOS, 7-nitroindazole had no effect. At 2.5 g RT, the reduction of [Ca2+]o from 2 mM to 0.2 mM abolished the effect of L-NAME on ACh-induced contractions. The NO precursor L-arginine or the tyrosine kinase inhibitors erbstatin A and genistein had no effect on ACh-induced contractions obtained at 2.5 g RT. Our results suggest that in airways, RT affects ACh-induced contractions by modulating the activity of epithelial NOS in a calcium-dependent, tyrosine-phosphorylation-independent way.

  19. Induction of expression of iNOS by N-nitrosodimethylamine (NDMA) in human leukocytes.

    Science.gov (United States)

    Ratajczak-Wrona, Wioletta; Jablonska, Ewa; Jablonski, Jakub; Marcinczyk, Magdalena

    2009-01-01

    The aim of this study was to assess the influence of N-nitrosodimethylamine (NDMA) on expression of inducible nitric oxide synthase (iNOS), as well as production of nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) by human neutrophils (PMN) and peripheral blood mononuclear cells (PBMC), and the participation of the p38 MAPK kinase in this process. Furthermore, the ability of neutrophils to release superoxide anion was determined. The influence of N-nitrosodimethylamine on iNOS expression was determined in isolated PMN and PBMC cells from peripheral blood of healthy individuals. The mononuclear cells showed higher sensitivity to NDMA. Moreover, cytotoxic effect of NDMA can be influenced in some way by the impact of this xenobiotic on nitric oxide and superoxide anion release from human leukocytes. Furthermore, increased generation of these radicals by human leukocytes suggest that neutrophils and mononuclear cells that are exposed to NDMA activity can play a key role in endogenous NDMA generation. However the relationship between iNOS expression and phospho-p38 MAPK in neutrophils and mononuclear cells shows that p38 MAPK pathway participates in induction of iNOS expression in the presence of NDMA.

  20. Inhibition of iNOS and DNA Oxidation by Methanol Extract of ...

    African Journals Online (AJOL)

    Purpose: To investigate the antioxidant properties of the methanol extract of S. tenuifolia as well as its effect on inducible nitric oxide synthase (iNOS) and cycleooxygenase-2 (COX-2) expression in lipopolysaccharides (LPS)-induced cell damage in macrophage cells. Methods: The antioxidant activities of the plant extract ...

  1. nNOS inhibitors attenuate methamphetamine-induced dopaminergic neurotoxicity but not hyperthermia in mice.

    Science.gov (United States)

    Itzhak, Y; Martin, J L; Ail, S F

    2000-09-11

    Methamphetamine (METH)-induced dopaminergic neurotoxicity is associated with hyperthermia. We investigated the effect of several neuronal nitric oxide synthase (nNOS) inhibitors on METH-induced hyperthermia and striatal dopaminergic neurotoxicity. Administration of METH (5 mg/kg; q. 3 h x 3) to Swiss Webster mice produced marked hyperthermia and 50-60% depletion of striatal dopaminergic markers 72 h after METH administration. Pretreatment with the nNOS inhibitors S-methylthiocitrulline (SMTC; 10 mg/kg) or 3-bromo-7-nitroindazole (3-Br-7-NI; 20 mg/kg) before each METH injection did not affect the persistent hyperthermia produced by METH, but afforded protection against the depletion of dopaminergic markers. A low dose (25 mg/kg) of the nNOS inhibitor 7-nitroindazole (7-NI) did not affect METH-induced hyperthermia, but a high dose (50 mg/kg) produced significant hypothermia. These findings indicate that low dose of selective nNOS inhibitors protect against METH-induced neurotoxicity with no effect on body temperature and support the hypothesis that nitric oxide (NO) and peroxynitrite have a major role in METH-induced dopaminergic neurotoxicity.

  2. From Orthodoxy to Plurality in the Nature of Science (NOS) and Science Education: A Metacommentary

    Science.gov (United States)

    Bazzul, Jesse

    2017-01-01

    This article provides a metacommentary on the special issue on nature of science (NOS). The issue is composed of senior scholars discussing Hodson and Wong's (2017, this issue) critique of the consensus view of nature of science, which on a basic level states that there are agreed-upon aspects of science that can be taught in K-12 schools. Each…

  3. Role of iNOS in Bystander Signaling Between Macrophages and Lymphoma Cells

    International Nuclear Information System (INIS)

    Ghosh, Somnath; Maurya, Dharmendra Kumar; Krishna, Malini

    2008-01-01

    Purpose: The present report describes the bystander effects of radiation between similar and dissimilar cells and the role of iNOS in such communication. Materials and Methods: EL-4 and RAW 264.7 cells were exposed to 5 Gy γ-irradiation. The medium from irradiated cells was transferred to unirradiated cells. Results: Irradiated EL-4 cells as well as those cultured in the presence of medium from γ-irradiated EL-4 cells showed an upregulation of NF-κB, iNOS, p53, and p21/waf1 genes. The directly irradiated and the bystander EL-4 cells showed an increase in DNA damage, apoptosis, and NO production. Bystander signaling was also found to exist between RAW 264.7 (macrophage) and EL-4 (lymphoma) cells. Unstimulated or irradiated RAW 264.7 cells did not induce bystander effect in unirradiated EL-4 cells, but LPS stimulated and irradiated RAW 264.7 cells induced an upregulation of NF-κB and iNOS genes and increased the DNA damage in bystander EL-4 cells. Treatment of EL-4 or RAW 264.7 cells with L-NAME significantly reduced the induction of gene expression and DNA damage in the bystander EL-4 cells, whereas treatment with cPTIO only partially reduced the induction of gene expression and DNA damage in the bystander EL-4 cells. Conclusions: It was concluded that active iNOS in the irradiated cells was essential for bystander response

  4. Decreased NOS1 expression in the anterior cingulate cortex in depression

    NARCIS (Netherlands)

    Gao, Shang-Feng; Qi, Xin-Rui; Zhao, Juan; Balesar, Rawien; Bao, Ai-Min; Swaab, Dick F.

    2013-01-01

    Decreased function of the anterior cingulate cortex (ACC) is crucially involved in the pathogenesis of depression. A key role of nitric oxide (NO) has also been proposed. We aimed to determine the NO content in the cerebrospinal fluid (CSF) and the expression of NO synthase (NOS) isoforms, that is,

  5. Animal Certifié Conforme: Déchiffrer nos Relations avec le Vivant

    Directory of Open Access Journals (Sweden)

    Daniel W. Gade

    2014-01-01

    Full Text Available Review of Animal Certifié Conforme: Déchiffrer nos Relations avec le Vivant. Bernadette Lizet and Jacqueline Milliet, eds. 2012. Dunod/Muséum National d’Histoire Naturelle, Paris. Pp 256. €22 (paperback. ISBN 9782100582853.

  6. Neuronal Nitric Oxide Synthase (NOS1) Polymorphisms Interact with Financial Hardship to Affect Depression Risk

    Science.gov (United States)

    Sarginson, Jane E; Deakin, JF William; Anderson, Ian M; Downey, Darragh; Thomas, Emma; Elliott, Rebecca; Juhasz, Gabriella

    2014-01-01

    There is increasing evidence that genetic factors have a role in differential susceptibility to depression in response to severe or chronic adversity. Studies in animals suggest that nitric oxide (NO) signalling has a key role in depression-like behavioural responses to stress. This study investigated whether genetic variation in the brain-expressed nitric oxide synthase gene NOS1 modifies the relationship between psychosocial stress and current depression score. We recruited a population sample of 1222 individuals who provided DNA and questionnaire data on symptoms and stress. Scores on the List of Life-Threatening Experiences (LTE) questionnaire for the last year and self-rated current financial hardship were used as measures of recent/ongoing psychosocial stress. Twenty SNPs were genotyped. Significant associations between eight NOS1 SNPs, comprising two regional haplotypes, and current depression score were identified that survived correction for multiple testing when current financial hardship was used as the interaction term. A smaller three-SNP haplotypes (rs10507279, rs1004356 and rs3782218) located in a regulatory region of NOS1 showed one of the strongest effects, with the A-C-T haplotype associating with higher depression scores at low adversity levels but lower depression scores at higher adversity levels (p=2.3E-05). These results suggest that NOS1 SNPs interact with exposure to economic and psychosocial stressors to alter individual's susceptibility to depression. PMID:24917196

  7. Enhancing Students' NOS Views and Science Knowledge Using Facebook-Based Scientific News

    Science.gov (United States)

    Huang, Hsi-Yu; Wu, Hui-Ling; She, Hsiao-Ching; Lin, Yu-Ren

    2014-01-01

    This study investigated how the different discussion approaches in Facebook influenced students' scientific knowledge acquisition and the nature of science (NOS) views. Two eighth- and two ninth-grade classes in a Taiwanese junior high school participated in the study. In two of the classes students engaged in synchronous discussion, and in the…

  8. Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background

    Directory of Open Access Journals (Sweden)

    Sara N. Koenig

    2015-03-01

    Full Text Available Thoracic aortic aneurysms (TAA are a significant cause of morbidity and mortality in humans. While the exact etiology is unknown, genetic factors play an important role. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV and aortopathy in humans. The aim of this study was to determine if haploinsufficiency of Notch1 contributes to aortopathy using Notch1+/−; Nos3−/− mice. Echocardiographic analysis of Notch1+/−; Nos3−/− mice reveals effacement of the sinotubular junction and a trend toward dilation of the aortic sinus. Furthermore, examination of the proximal aorta of Notch1+/−; Nos3−/− mice reveals elastic fiber degradation, a trend toward increased matrix metalloproteinase 2 expression, and increased smooth muscle cell apoptosis, features characteristic of aneurysmal disease. Although at a lower penetrance, we also found features consistent with aortopathic changes in Notch1 heterozygote mice and in Nos3-null mice. Our findings implicate a novel role for Notch1 in aortopathy of the proximal aorta.

  9. Association between nucleotide mutation of eNOS gene and serum ...

    African Journals Online (AJOL)

    Galaxy

    2013-05-15

    May 15, 2013 ... spasm among Japanese (Nakayama et al., 1999; Casas et al., 2006). It is believed that these mutations might result in altered NO metabolism and impaired .... ship between T-786C mutation of eNOS gene and CAD specifically in the Iranian population. To our knowledge, this polymorphism has never been ...

  10. Association of eNOS and HSP70 gene polymorphisms with glaucoma in Pakistani cohorts.

    NARCIS (Netherlands)

    Ayub, H.; Khan, M.I.; Micheal, S.; Akhtar, F.; Ajmal, M.; Shafique, S.; Ali, S.H.; Hollander, A.I. den; Ahmed, A.; Qamar, R.

    2010-01-01

    PURPOSE: To investigate the involvement of stress-regulating genes, endothelial nitric oxide synthase (eNOS) and heat shock protein 70 (HSP70) with primary open angle glaucoma (POAG) and primary closed angle glaucoma (PCAG). METHODS: POAG and PCAG patients recruited from different areas of Pakistan

  11. Morus alba extract modulates blood pressure homeostasis through eNOS signaling.

    Science.gov (United States)

    Carrizzo, Albino; Ambrosio, Mariateresa; Damato, Antonio; Madonna, Michele; Storto, Marianna; Capocci, Luca; Campiglia, Pietro; Sommella, Eduardo; Trimarco, Valentina; Rozza, Francesco; Izzo, Raffaele; Puca, Annibale A; Vecchione, Carmine

    2016-10-01

    Morus alba is a promising phytomedicine cultivated in oriental countries that is extensively used to prevent and treat various cardiovascular problems. To date, despite its beneficial effects, the molecular mechanisms involved remain unclear. Thus, we investigate the vascular and haemodynamic effects of Morus alba extract in an experimental model focusing our attention on the molecular mechanisms involved. Through vascular reactivity studies, we demonstrate that Morus alba extract evokes endothelial vasorelaxation through a nitric oxide-dependent pathway. Our molecular analysis highlights an increase in endothelial nitric oxide synthase (eNOS) phosphorylation. In vivo administration of Morus alba extract reduces blood pressure levels exclusively in wild-type mice, whereas it fails to evoke any haemodynamic effects in eNOS-deficient mice. Molecular analyses revealed that its beneficial action on vasculature is mediated by the activation of two important proteins that act as stress sensors and chaperones: PERK and heat shock protein 90. Finally, Morus alba extract exerts antihypertensive action in an experimental model of arterial hypertension. Through its action on eNOS signaling, Morus alba extract could act as a food supplement for the regulation of cardiovascular system, mainly in clinical conditions characterized by eNOS dysfunction, such as arterial hypertension. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Association of the NOS3 intron-4 VNTR polymorphism with aneurysmal subarachnoid hemorrhage

    DEFF Research Database (Denmark)

    Staalsø, Jonatan Myrup; Edsen, Troels; Kotinis, Alexandros

    2014-01-01

    OBJECT: The nitric oxide system has been linked to the pathogenesis of aneurysmal subarachnoid hemorrhage (SAH). The authors performed a case-control study to investigate the association between SAH and common genetic variants within the endothelial nitric oxide synthase gene (NOS3). METHODS: Thr...

  13. Neuronal nitric oxide synthase (NOS1) polymorphisms interact with financial hardship to affect depression risk.

    Science.gov (United States)

    Sarginson, Jane E; Deakin, J F William; Anderson, Ian M; Downey, Darragh; Thomas, Emma; Elliott, Rebecca; Juhasz, Gabriella

    2014-11-01

    There is increasing evidence that genetic factors have a role in differential susceptibility to depression in response to severe or chronic adversity. Studies in animals suggest that nitric oxide (NO) signalling has a key role in depression-like behavioural responses to stress. This study investigated whether genetic variation in the brain-expressed nitric oxide synthase gene NOS1 modifies the relationship between psychosocial stress and current depression score. We recruited a population sample of 1222 individuals who provided DNA and questionnaire data on symptoms and stress. Scores on the List of Life-Threatening Experiences (LTE) questionnaire for the last year and self-rated current financial hardship were used as measures of recent/ongoing psychosocial stress. Twenty SNPs were genotyped. Significant associations between eight NOS1 SNPs, comprising two regional haplotypes, and current depression score were identified that survived correction for multiple testing when current financial hardship was used as the interaction term. A smaller three-SNP haplotypes (rs10507279, rs1004356 and rs3782218) located in a regulatory region of NOS1 showed one of the strongest effects, with the A-C-T haplotype associating with higher depression scores at low adversity levels but lower depression scores at higher adversity levels (p=2.3E-05). These results suggest that NOS1 SNPs interact with exposure to economic and psychosocial stressors to alter individual's susceptibility to depression.

  14. Psychomteric Validation of the Health of Nation Outcome Scales (HoNOS) in Traumatized Refugees

    DEFF Research Database (Denmark)

    Palic, Sabina; Elklit, Ask; Makransky, Guido

    -treatment data from 448 consecutive patients at three Danish psychiatric clinics for refugees. A10-item HoNOS version (physical problems and daily function items excluded) of pre-treatment data fit the Rasch model well. A cross validation showed excellent fit of the post-treatment data to the 10-item model...

  15. 77 FR 12010 - Marine Mammals; File Nos. 1076-1789 and 14502

    Science.gov (United States)

    2012-02-28

    ... NMFS to study and document the health and biology of wild marine mammals as well as those marine... DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration RIN 0648-XB040 Marine Mammals; File Nos. 1076-1789 and 14502 AGENCY: National Marine Fisheries Service (NMFS), National Oceanic...

  16. Using Video Modeling to Teach Children with PDD-NOS to Respond to Facial Expressions

    Science.gov (United States)

    Axe, Judah B.; Evans, Christine J.

    2012-01-01

    Children with autism spectrum disorders often exhibit delays in responding to facial expressions, and few studies have examined teaching responding to subtle facial expressions to this population. We used video modeling to train 3 participants with PDD-NOS (age 5) to respond to eight facial expressions: approval, bored, calming, disapproval,…

  17. Sociodemographic, neuropsychiatric and cognitive characteristics of pathological gambling and impulse control disorders NOS in Parkinson's disease.

    Science.gov (United States)

    Pontieri, Francesco E; Assogna, Francesca; Pellicano, Clelia; Cacciari, Claudia; Pannunzi, Sara; Morrone, Annalucia; Danese, Emanuela; Caltagirone, Carlo; Spalletta, Gianfranco

    2015-01-01

    Despite of previous evidence supporting the association between impulse control disorder (ICD) and several demographic, clinical and therapeutic features in Parkinson's disease (PD), the relationships between pathological gambling (PG) or other variants of ICD (ICD-NOS) and specific neuropsychiatric or cognitive domains are not entirely defined. In this study, 155 PD patients without dementia or cognitive impairment underwent: i. the ICD diagnoses, using the Questionnaire for Impulsive-Compulsive Disorders, ii. the mood and anxiety disorders diagnoses, according to the DSM-IV-TR criteria, and iii. a comprehensive battery for measuring severity of psychopathology and neuropsychology domains. Patients were divided in those with pathological gambling (PG), ICDs not otherwise specified (ICD-NOS), or the lack of ICD (No-ICD). There was a progression in age and age at onset from the younger PG subjects throughout ICD-NOS to No-ICD. PG and ICD-NOS subjects had longer disease duration and were taking significantly higher dosages of antiparkinsonian drugs than No-ICD ones. PG subjects had significantly higher severity of depressive and anxious symptoms with respect to the other 2 groups. Both PG and ICD-NOS subjects suffer from increased severity of psychotic symptoms than No-ICD ones. The 3 groups did not differ in any cognitive measure. Our results support the concept that the different sociodemographic and neuropsychiatric profiles of PD patients are associated with different ICDs. Moreover, we clearly demonstrate the lack of relationship between ICD and cognitive performances in undemented PD patients. Copyright © 2014 Elsevier B.V. and ECNP. All rights reserved.

  18. Gender, exercise training, and eNOS expression in porcine skeletal muscle arteries.

    Science.gov (United States)

    Laughlin, M Harold; Welshons, Wade V; Sturek, Michael; Rush, James W E; Turk, James R; Taylor, Julia A; Judy, Barbara M; Henderson, Kyle K; Ganjam, V K

    2003-07-01

    Our purpose was to determine the effects of gender and exercise training on endothelial nitric oxide synthase (eNOS) and superoxide dismutase (SOD) protein content of porcine skeletal muscle arteries and to evaluate the role of 17beta-estradiol (E2) in these effects. We measured eNOS and SOD content with immunoblots and immunohistochemistry in femoral and brachial arteries of trained and sedentary male and female pigs and measured estrogen receptor (ER) mRNA and alpha-ER and beta-ER protein in aortas of male and female pigs. Results indicate that female arteries contain more eNOS than male arteries and that exercise training increases eNOS content independent of gender. Male and female pigs expressed similar levels of alpha-ER mRNA and protein and similar amounts beta-ER protein in their arteries. E2 concentrations as measured by RIA were 180 +/- 34 pg/ml in male sera and approximately 5 pg/ml in female sera, and neither was changed by training. However, bioassay indicated that biologically active estrogen equivalent to only 35 +/- 5 pg/ml was present in male sera. E2 in female pigs, whether measured by RIA or bioassay, was approximately 24 pg/ml at peak estrous and 2 pg/ml on day 5 diestrus. The free fraction of E2 in sera did not explain the low measurements, relative to RIA, of E2. We conclude that 1). gender has significant influence on eNOS and SOD content of porcine skeletal muscle arteries; 2). the effects of gender and exercise training vary among arteries of different anatomic origin; 3). male sera contains compounds that cause RIA to overestimate circulating estrogenic activity; and 4). relative to human men, the male pig is not biologically estrogenized by high levels of E2 reported by RIA, whereas in female pigs E2 levels are lower than in the blood of human women.

  19. Effects of a selective iNOS inhibitor versus norepinephrine in the treatment of septic shock.

    Science.gov (United States)

    Su, Fuhong; Huang, Hongchuan; Akieda, Kazuki; Occhipinti, Giovanna; Donadello, Katia; Piagnerelli, Michael; De Backer, Daniel; Vincent, Jean-Louis

    2010-09-01

    Inhibition of NOS is not beneficial in septic shock; selective inhibition of the inducible form (iNOS) may represent a better option. We compared the effects of the selective iNOS inhibitor BYK191023 with those of norepinephrine (NE) in a sheep model of septic shock. Twenty-four anesthetized, mechanically ventilated ewes received 1.5 g/kg body weight of feces into the abdominal cavity to induce sepsis. Animals were randomized into three groups (each n = 8): NE-only, BYK-only, and NE + BYK. The sublingual microcirculation was evaluated with sidestream dark-field videomicroscopy. MAP was higher in the NE + BYK group than in the other groups, but there were no significant differences in cardiac index or systemic vascular resistance. Mean pulmonary arterial pressure was lower in BYK-treated animals than in the NE-only group. PaO2/FiO2 was higher and lactate concentration lower in the BYK groups than in the NE-only group. Mesenteric blood flow was higher in BYK groups than in the NE-only group. Renal blood flow was higher in the NE + BYK group than in the other groups. Functional capillary density and proportion of perfused vessels were higher in the BYK groups than in the NE-only group 18 h after induction of peritonitis. Survival times were similar in the three groups. In this model of peritonitis, selective iNOS inhibition had more beneficial effects than NE on pulmonary artery pressures, gas exchange, mesenteric blood flow, microcirculation, and lactate concentration. Combination of this selective iNOS inhibitor with NE allowed a higher arterial pressure and renal blood flow to be maintained.

  20. Intervención familiar para el manejo psicológico en pacientes oncológicos con mal pronóstico en el hospital de la Misericordia

    Directory of Open Access Journals (Sweden)

    Ana Carolina Rodríguez Ibarra

    2004-01-01

    Full Text Available Se diseñó un programa fundamentado en el modelo cognitivo conductual de Inoculación de Estrés e intervención en duelo anticipatorio basado en cuatro tareas. El programa fue aplicado a tres pacientes con mal pronóstico del Servicio de Oncohematología del Hospital de la Misericordia y a sus familias. Por medio de estudio de caso, se describieron factores de riesgo y de protección así como respuestas frente a dicha intervención. El análisis cualitativo de casos arrojó la descripción de respuestas a pérdidas previas no elaboradas, pautas de comunicación deficiente en uno de los casos, y reconocimiento de apoyo al interior de cada familia. Según el reporte de los participantes, la intervención permitió la expresión de sentimientos, la reflexión sobre el sentido de la vida, incremento de posibilidades y habilidades de comunicación y orientación hacia la solución de problemas y toma de decisiones.