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Sample records for quartet model

  1. Model-independent determination of doublet and quartet cross sections in Nd fusion

    CERN Document Server

    Ramachandran, G

    2001-01-01

    A model-independent theoretical formalism is outlined to describe Nd fusion in terms of irreducible tensor amplitudes labelled by the initial channel spins s=((1)/(2)),((3)/(2)). A comprehensive form for the initial spin density matrix rho is given in the channel spin representation, when both the beam and target are polarized. It is then suggested that an incisive study of Nd fusion may be carried out employing a polarized beam on a polarized target, leading to the determination of the differential cross sections for the doublet and quartet states individually.

  2. The Quartet does not play alone. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Marco-Pallarés, Josep; Mas-Herrero, Ernest

    2015-06-01

    The study of emotions has been an important topic in cognitive and affective neuroscience in the last decades. In the present manuscript, Koelsch et al. [1] propose a new neurobiological framework based on four emotional core systems (the Quartet), involved in different aspects of human emotion processing. This is an interesting theory that goes beyond classical emotion classification to describe the emotional experience based on four main cerebral components (brainstem, diencephalon, hippocampus, and orbitofrontal cortex). This approach allows the description of different classes of affects, including those that are unique in humans as emotional responses associated to abstract stimuli (for example, aesthetical stimuli such as art and music).

  3. The quartet theory: Implications for autism spectrum disorder. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Pehrs, Corinna; Samson, Andrea C.; Gross, James J.

    2015-06-01

    Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by social and communication deficits as well as restricted and repetitive behaviors [1]. Specific deficits include failure to initiate reciprocal social interactions, verbal and non-verbal communication difficulties, decreased sensitivity to social and emotional cues, and limited perspective-taking abilities. Social withdrawal, avoidance or indifference to affection or physical contact, lack of eye contact, and decreased joint attention and facial responsiveness are also common [2]. In addition to these core features, there is a growing body of literature that describes problematic patterns of emotional reactivity (increased negative and decreased positive emotions) and emotion regulation (increased use of maladaptive and decreased use of adaptive emotion regulation strategies) [3-5]. The present comment seeks to link difficulties in socio-emotional domains to the Quartet Theory of Human Emotions by mapping characteristic ASD social deficits and emotion dysregulation onto two of the affect systems described in this theory: the hippocampal and orbitofrontal-centered systems.

  4. The quartet theory of human emotions: An integrative and neurofunctional model.

    Science.gov (United States)

    Koelsch, Stefan; Jacobs, Arthur M; Menninghaus, Winfried; Liebal, Katja; Klann-Delius, Gisela; von Scheve, Christian; Gebauer, Gunter

    2015-06-01

    Despite an explosion of research in the affective sciences during the last few decades, interdisciplinary theories of human emotions are lacking. Here we present a neurobiological theory of emotions that includes emotions which are uniquely human (such as complex moral emotions), considers the role of language for emotions, advances the understanding of neural correlates of attachment-related emotions, and integrates emotion theories from different disciplines. We propose that four classes of emotions originate from four neuroanatomically distinct cerebral systems. These emotional core systems constitute a quartet of affect systems: the brainstem-, diencephalon-, hippocampus-, and orbitofrontal-centred affect systems. The affect systems were increasingly differentiated during the course of evolution, and each of these systems generates a specific class of affects (e.g., ascending activation, pain/pleasure, attachment-related affects, and moral affects). The affect systems interact with each other, and activity of the affect systems has effects on - and interacts with - biological systems denoted here as emotional effector systems. These effector systems include motor systems (which produce actions, action tendencies, and motoric expression of emotion), peripheral physiological arousal, as well as attentional and memory systems. Activity of affect systems and effector systems is synthesized into an emotion percept (pre-verbal subjective feeling), which can be transformed (or reconfigured) into a symbolic code such as language. Moreover, conscious cognitive appraisal (involving rational thought, logic, and usually language) can regulate, modulate, and partly initiate, activity of affect systems and effector systems. Our emotion theory integrates psychological, neurobiological, sociological, anthropological, and psycholinguistic perspectives on emotions in an interdisciplinary manner, aiming to advance the understanding of human emotions and their neural correlates.

  5. The quartet theory of human emotions: An integrative and neurofunctional model

    Science.gov (United States)

    Koelsch, Stefan; Jacobs, Arthur M.; Menninghaus, Winfried; Liebal, Katja; Klann-Delius, Gisela; von Scheve, Christian; Gebauer, Gunter

    2015-06-01

    Despite an explosion of research in the affective sciences during the last few decades, interdisciplinary theories of human emotions are lacking. Here we present a neurobiological theory of emotions that includes emotions which are uniquely human (such as complex moral emotions), considers the role of language for emotions, advances the understanding of neural correlates of attachment-related emotions, and integrates emotion theories from different disciplines. We propose that four classes of emotions originate from four neuroanatomically distinct cerebral systems. These emotional core systems constitute a quartet of affect systems: the brainstem-, diencephalon-, hippocampus-, and orbitofrontal-centred affect systems. The affect systems were increasingly differentiated during the course of evolution, and each of these systems generates a specific class of affects (e.g., ascending activation, pain/pleasure, attachment-related affects, and moral affects). The affect systems interact with each other, and activity of the affect systems has effects on - and interacts with - biological systems denoted here as emotional effector systems. These effector systems include motor systems (which produce actions, action tendencies, and motoric expression of emotion), peripheral physiological arousal, as well as attentional and memory systems. Activity of affect systems and effector systems is synthesized into an emotion percept (pre-verbal subjective feeling), which can be transformed (or reconfigured) into a symbolic code such as language. Moreover, conscious cognitive appraisal (involving rational thought, logic, and usually language) can regulate, modulate, and partly initiate, activity of affect systems and effector systems. Our emotion theory integrates psychological, neurobiological, sociological, anthropological, and psycholinguistic perspectives on emotions in an interdisciplinary manner, aiming to advance the understanding of human emotions and their neural correlates.

  6. Optimal feedback correction in string quartet synchronization.

    Science.gov (United States)

    Wing, Alan M; Endo, Satoshi; Bradbury, Adrian; Vorberg, Dirk

    2014-04-06

    Control of relative timing is critical in ensemble music performance. We hypothesize that players respond to and correct asynchronies in tone onsets that arise from fluctuations in their individual tempos. We propose a first-order linear phase correction model and demonstrate that optimal performance that minimizes asynchrony variance predicts a specific value for the correction gain. In two separate case studies, two internationally recognized string quartets repeatedly performed a short excerpt from the fourth movement of Haydn's quartet Op. 74 no. 1, with intentional, but unrehearsed, expressive variations in timing. Time series analysis of successive tone onset asynchronies was used to estimate correction gains for all pairs of players. On average, both quartets exhibited near-optimal gain. However, individual gains revealed contrasting patterns of adjustment between some pairs of players. In one quartet, the first violinist exhibited less adjustment to the others compared with their adjustment to her. In the second quartet, the levels of correction by the first violinist matched those exhibited by the others. These correction patterns may be seen as reflecting contrasting strategies of first-violin-led autocracy versus democracy. The time series approach we propose affords a sensitive method for investigating subtle contrasts in music ensemble synchronization.

  7. Quartetting in odd-odd self-conjugate nuclei

    CERN Document Server

    Sambataro, M

    2016-01-01

    We provide a description of odd-odd self-conjugate nuclei in the sd shell in a formalism of collective quartets and pairs. Quartets are four-body structures carrying isospin T=0 while pairs can have either T=0 or T=1. Both quartets and pairs are labeled by the angular momentum J and they are chosen so as to describe the lowest states of 20Ne (quartets) and the lowest T=0 and T=1 states of 18F (pairs). We carry out configuration interaction calculations in spaces built by one quartet and one pair for 22Na and by two quartets and one pair for 26Al. The spectra that are generated are in good agreement with the shell model and experimental ones. These calculations confirm the relevance of quartetting in the structure of N=Z nuclei that had already emerged in previous studies of the even-even systems and highlight the role of J>0 quartets in the composition of the odd-odd spectra.

  8. Orchestrating emotion and action in an evolutionary framework. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Arbib, Michael A.

    2015-06-01

    The lead author of the Quartet Theory [10] is, appropriately enough, an expert on the neuroscience linking music and emotion, and examples of this linkage are a welcome feature of the article. Actually, the article charts two quartets: A structural quartet of affect systems centered on (i) brainstem, (ii) diencephalon, (iii) hippocampus and (iv) orbitofrontal cortex.

  9. Instruments, conductors, dancers, and intendants. Reply to comments on "The quartet theory of human emotions: An integrative and neurofunctional model"

    Science.gov (United States)

    Koelsch, Stefan

    2015-06-01

    I am happy about each commentator's contribution [1-27], about the wealth of the kind and generally positive comments, and the many interesting and enriching remarks, observations, and extensions. In the following, I will summarize some major points of the comments, and relate them to the Quartet Theory (henceforth QT) proposed in the target article [28].

  10. From neuro-functional to neuro-computational models. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Briesemeister, Benny B.

    2015-06-01

    Historically, there has been a strong opposition between psychological theories of human emotion that suggest a limited number of distinct functional categories, such as anger, fear, happiness and so forth (e.g. [1]), and theories that suggest processing along affective dimensions, such as valence and arousal (e.g. [2]). Only few current models acknowledge that both of these perspectives seem to be legitimate [3], and at their core, even fewer models connect these insights with knowledge about neurophysiology [4]. In this regard, the Quartet Theory of Human Emotions (QTHE) [5] makes a very important and useful contribution to the field of emotion research - but in my opinion, there is still at least one more step to go.

  11. Musical rhythm and affect. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Witek, Maria A. G.; Kringelbach, Morten L.; Vuust, Peter

    2015-06-01

    The Quartet Theory of Human Emotion (QT) proposed by Koelsch et al. [1] adds to existing affective models, e.g. by directing more attention to emotional contagion, attachment-related and non-goal-directed emotions. Such an approach seems particularly appropriate to modelling musical emotions, and music is indeed a recurring example in the text, used to illustrate the distinct characteristics of the affect systems that are at the centre of the theory. Yet, it would seem important for any theory of emotion to account for basic functions such as prediction and anticipation, which are only briefly mentioned. Here we propose that QT, specifically its focus on emotional contagion, attachment-related and non-goal directed emotions, might help generate new ideas about a largely neglected source of emotion - rhythm - a musical property that relies fundamentally on the mechanism of prediction.

  12. Evolutionary considerations on complex emotions and music-induced emotions. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Gingras, Bruno; Marin, Manuela M.

    2015-06-01

    Recent efforts to uncover the neural underpinnings of emotional experiences have provided a foundation for novel neurophysiological theories of emotions, adding to the existing body of psychophysiological, motivational, and evolutionary theories. Besides explicitly modeling human-specific emotions and considering the interactions between emotions and language, Koelsch et al.'s original contribution to this challenging endeavor is to identify four brain areas as distinct "affect systems" which differ in terms of emotional qualia and evolutionary pathways [1]. Here, we comment on some features of this promising Quartet Theory of Emotions, focusing particularly on evolutionary and biological aspects related to the four affect systems and their relation to prevailing emotion theories, as well as on the role of music-induced emotions.

  13. QDist—Quartet Distance Between Evolutionary Trees

    DEFF Research Database (Denmark)

    Mailund; Pedersen, Christian N. Storm

    2004-01-01

    QDist is a program for computing the quartet distance between two unrooted evolutionary trees, i.e. the number of quartet topology differences between the two trees, where a quartet topology is the topological subtree induced by four species. The implementation is based on an algorithm with running...... time O(n log² n), which makes it practical to compare large trees....

  14. Treatment of like-particle pairing with quartets

    CERN Document Server

    Sambataro, M

    2013-01-01

    The ground state correlations induced by a general pairing Hamiltonian in a finite system of like fermions are described in terms of four-body correlated structures (quartets). These are real superpositions of products of two pairs of particles in time-reversed states. Quartets are determined variationally through an iterative sequence of diagonalizations of the Hamiltonian in restricted model spaces and are, in principle, all distinct from one another. The ground state is represented as a product of quartets to which, depending on the number of particles (supposed to be even, in any case), an extra collective pair is added. The extra pair is also determined variationally. In case of pairing in a spherically symmetric mean field, both the quartets and the extra pair (if any) are characterized by a total angular momentum J=0. Realistic applications of the quartet formalism are carried out for the Sn isotopes with the valence neutrons in the 50-82 neutron shell. Exact ground state correlation energies, occupati...

  15. Topical application of a G-Quartet aptamer targeting nucleolin attenuates choroidal neovascularization in a model of age-related macular degeneration.

    Science.gov (United States)

    Leaderer, Derek; Cashman, Siobhan M; Kumar-Singh, Rajendra

    2015-11-01

    Choroidal neovascularization (CNV) associated with the 'wet' form of age related macular degeneration (AMD) is one of the most common causes of central vision loss among the elderly. The 'wet' form of AMD is currently treated by intravitreal delivery of anti-VEGF agents. However, intravitreal injections are associated with complications and long-term inhibition of VEGF leads to macular atrophy. Thus, there is currently an unmet need for the development of therapies for CNV that target molecules other than VEGF. Here, we describe nucleolin as a novel target for the 'wet' form of AMD. Nucleolin was found on the surface of endothelial cells that migrate from the choroid into the subretinal space in the laser-induced model of 'wet' AMD. AS1411 is a previously described G-quartet oligonucleotide that has been shown to bind nucleolin. We found that AS1411 inhibited the formation of tubes by human umbilical vein endothelial cells (HUVECs) by approximately 27.4% in vitro. AS1411 co-localized with the site of laser induced CNV in vivo. Intravitreally injected AS1411 inhibited laser-induced CNV by 37.6% and attenuated infiltration of macrophages by 40.3%. Finally, topical application of AS1411 led to a 43.4% reduction in CNV. Our observations have potential implications for the development of therapies for CNV and specifically for the 'wet' form of AMD.

  16. Pairing versus quarteting coherence length

    CERN Document Server

    Delion, Doru S

    2015-01-01

    We systematically analyse the coherence length in even-even nuclei. The pairing coherence length in the spin-singlet channel for the effective density dependent delta (DDD) and Gaussian interaction is estimated. We consider in our calculations bound states as well as narrow resonances. It turns out that the pairing gaps given by the DDD interaction are similar to those of the Gaussian potential if one renormalizes the radial width to the nuclear radius. The correlations induced by the pairing interaction have in all considered cases a long range character inside the nucleus and decrease towards the surface. The mean coherence length is larger than the geometrical radius for light nuclei and approaches this value for heavy nuclei. The effect of the temperature and states in continuum is investigated. Strong shell effects are evidenced, especially for protons. We generalize this concept to quartets by considering similar relations, but between proton and neutron pairs. The quartet coherence length has a similar...

  17. Language limits the experience of emotions. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Wood, Adrienne; Niedenthal, Paula

    2015-06-01

    Emotions are phylogenetically ancient and involve complex interactions of neural, behavioral, and physiological processes. A complete theory of emotions must incorporate, or at least be informed by, current knowledge from neurobiology and comparative psychology [1]. The Quartet Theory of Human Emotions by Koelsch and colleagues [2] is therefore a welcome step towards a more integrative affective science.

  18. Emotion and language - When and how comes emotion into words?. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Braun, Mario

    2015-06-01

    The Quartet Theory of Emotion [13] is the first emotion theory to include language as part of its four affect systems allocating two functions of language in emotion processing: communication and regulation. Both are supposed to occur late during the emotion process and by translation or reconfiguration of a pre-verbal emotion percept into a symbolic language code which then gives rise to the conscious experience of an emotion allowing communication or regulation [14] of a felt emotion.

  19. Bridges from affect to language. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Schmidtke, David S.; Aryani, Arash

    2015-06-01

    The comprehensive Quartet Theory of Human Emotions proposed by Koelsch et al. [4] offers an exceptional synopsis regarding major developments in affective neuroscience, encompassing classical data based on animal studies as well as emotions generally classified as uniquely human. In doing so, it becomes apparent that while general anatomical grounds appear well covered mainly based on animal studies, neuroanatomical underpinnings of interactions between emotion and language may not be readily understood.

  20. Quartet correlations in N = Z nuclei induced by realistic two-body interactions

    Energy Technology Data Exchange (ETDEWEB)

    Sambataro, M. [Istituto Nazionale di Fisica Nucleare - Sezione di Catania, Catania (Italy); Sandulescu, N. [National Institute of Physics and Nuclear Engineering, Bucharest-Magurele (Romania)

    2017-03-15

    Two variational quartet models previously employed in a treatment of pairing forces are extended to the case of a general two-body interaction. One model approximates the nuclear states as a condensate of identical quartets with angular momentum J = 0 and isospin T = 0 while the other let these quartets to be all different from each other. With these models we investigate the role of alpha-like quartet correlations both in the ground state and in the lowest J = 0, T = 0 excited states of even-even N = Z nuclei in the sd -shell. We show that the ground-state correlations of these nuclei can be described to a good extent in terms of a condensate of alpha-like quartets. This turns out to be especially the case for the nucleus {sup 32}S for which the overlap between this condensate and the shell model wave function is found close to one. In the same nucleus, a similar overlap is found also in the case of the first excited 0{sup +} state. No clear correspondence is observed instead between the second excited states of the quartet models and the shell model eigenstates in all the cases examined. (orig.)

  1. Philosophical elements in four quartets

    Directory of Open Access Journals (Sweden)

    A. J. Weideman

    1977-03-01

    Full Text Available Four Quartets serves as an illustration of the undeniable fact that Western literature forms a unity, and bears out the truth of Eliot’s statement that “the whole of the literature of Europe from Homer... has a simultaneous existence and composes a si­ multaneous order” !. Again, as is the case with most other criti­ cal remarks on Four Quartets, the contents of the poems them­ selves serve as timely reminders of this fact, and thus seem to provide a more legitimate material basis for critical enquiry. For on several occasions Eliot takes up this point, and perhaps no­ where as unambiguously as in East Coker: “ And what there is to conquer By strength and submission, has already been discovered Once or twice, or several times, by men whom one cannot hope To emulate — but there is no competition — There is only the fight to recover what has been lost And found and lost again and again...”

  2. Human emotion in the brain and the body: Why language matters. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Herbert, Cornelia

    2015-06-01

    What is an Emotion? This question has fascinated scientific research since William James. Despite the fact that a consensus has been reached about the biological origin of emotions, uniquely human aspects of emotions are still poorly understood. One of these blind spots concerns the relationship between emotion and human language. Historically, many theories imply a duality between emotions on the one hand and cognitive functions such as language on the other hand. Especially for symbolic forms of written language and word processing, it has been assumed that semantic information would bear no relation to bodily, affective, or sensorimotor processing (for an overview see Ref. [1]). The Quartet Theory proposed by Koelsch and colleagues [2] could provide a solution to this problem. It offers a novel, integrative neurofunctional model of human emotions which considers language and emotion as closely related. Crucially, language - be it spoken or written - is assumed to "regulate, modulate, and partly initiate" activity in core affective brain systems in accord with physical needs and individual concerns [cf. page 34, line 995]. In this regard, the Quartet Theory combines assumptions from earlier bioinformational theories of emotions [3], contemporary theories of embodied cognition [4], and appraisal theories such as the Component Process Model [5] into one framework, thereby providing a holistic model for the neuroscientific investigation of human emotion processing at the interface of emotion and cognition, mind and body.

  3. Aesthetic Alliances in Poetry and Music: T. S. Eliot's Four Quartets and String Quartets by Bela Bartok.

    Science.gov (United States)

    Boaz, Mildred Meyer

    1979-01-01

    This paper argues that, although T. S. Eliot's "Four Quartets" provoke comparisons with the late quartets of Beethoven, an analysis of Four Quartets and Bela Bartok's Fourth and Fifth String Quartets produces a clearer understanding of the formal structures in the poetry and music. Symmetries offset asymmetries. (Author/KC)

  4. Quartets and unrooted phylogenetic networks.

    Science.gov (United States)

    Gambette, Philippe; Berry, Vincent; Paul, Christophe

    2012-08-01

    Phylogenetic networks were introduced to describe evolution in the presence of exchanges of genetic material between coexisting species or individuals. Split networks in particular were introduced as a special kind of abstract network to visualize conflicts between phylogenetic trees which may correspond to such exchanges. More recently, methods were designed to reconstruct explicit phylogenetic networks (whose vertices can be interpreted as biological events) from triplet data. In this article, we link abstract and explicit networks through their combinatorial properties, by introducing the unrooted analog of level-k networks. In particular, we give an equivalence theorem between circular split systems and unrooted level-1 networks. We also show how to adapt to quartets some existing results on triplets, in order to reconstruct unrooted level-k phylogenetic networks. These results give an interesting perspective on the combinatorics of phylogenetic networks and also raise algorithmic and combinatorial questions.

  5. The multi-instrumentalist hippocampus. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Strange, Bryan A.; Yebra, Mar

    2015-06-01

    Characterizing the neural circuitry of emotion is important not only from a basic science perspective, but also for understanding how these circuits may malfunction in psychiatric disease. A fundamental question for affective neuroscience is whether there are specialised neuroanatomical areas, or "modules", dedicated to the processing of emotional stimuli. In their review, Koelsch and colleagues [1] argue for the existence of a quartet of neuroanatomically distinct cerebral systems involved in the generation of a specific class of affects. Intriguingly, all four systems (brainstem-, diencephalon-, hippocampus-, and orbitofrontal-centred) comprise brain areas whose role in emotional processing is in addition to mediating other specific aspects of cognition. One member of the quartet in which this is particularly apparent is the hippocampus, a structure known to be critical for episodic memory and navigation. If areas involved in emotion also mediate other brain functions, this raises an issue of whether these multiple functions are executed by segregated circuits within each structure - i.e., a "module" for emotion residing in a sub-division of a brain structure - or whether these circuits are superimposed.

  6. Evolutionary perspectives on emotions and their link to intentions, dispositions and behavior. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Wildgruber, Dirk; Kreifelts, Benjamin

    2015-06-01

    Koelsch and coworkers present a sophisticated neuroanatomical model of emotions comprising four affect-systems and four output-systems, each bound to a specific brain area [1]. Moreover, they suggest the emergence of distinct components of subjective feelings or "emotion percepts" due to integration of the activation across these subsystems. Incorporating numerous neurobiological, psychological and philosophical findings on human emotions, the model reflects an extensive interdisciplinary approach. Considering an evolutionary perspective, however, we would like to address some issues concerning emotions and their link to intentions, dispositions and behavior that are not fully covered by the Quartet Model. Charles Darwin pointed out that individuals that are better adapted to their environment have increased chances of survival and reproduction. Therefore, natural selection leads to a rising prevalence of properties offering a survival benefit across generations [2]. To better understand the biological functions of emotions we propose to ask the question: How do emotions provide a benefit for survival and reproduction?

  7. Aesthetic emotions goals. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Perlovsky, Leonid

    2015-06-01

    Review by Koelsch et al. [10] presents an interdisciplinary theory of emotions, including a neurobiological emotion theory originating in four core emotional systems. The Quartet Theory (QT) includes specifically human emotions and considers the role of language for emotions. This comment considers questions about how the QT can address aesthetic emotions, what class of emotions they are, and what their function in cognition is. Can QT help defining aesthetic emotions neurally and functionally? Such a definition of aesthetic emotions would be necessary for their scientific exploration, because as widely used today there is no definition, aesthetics is defined through art, and art through aesthetics. Since contents of many art museums are not accepted as art by many artists and admirers of art, it is not clear what should be the subject of aesthetic emotions research.

  8. Countdown for the Cluster quartet

    Science.gov (United States)

    2000-07-01

    Following the successful completion of the Cluster II Flight Readiness Review on 23 June, final launch preparations are progressing smoothly and combined operations with the Soyuz-Fregat launch vehicle are now under way. The dual launches, each involving two Cluster spacecraft built under the prime contractorship of Astrium (former Dornier Satellitensysteme GmbH, Germany), are currently scheduled for 15 July with a launch window opening at 14:40 CEST, 12:40 GMT and lasting 6 minutes, and 9 August from Baikonur Space Centre in Kazakhstan. A number of press events have been organised in various countries to coincide with both launches. The main press centre for the first launch will be located at ESA's European Space Operations Centre (ESOC) at Darmstadt in Germany. Local press centres are also being set up in the other ESA establishments: ESRIN (Italy), ESTEC (The Netherlands), and VILSPA (Spain). See attachment for more detailed information and reply form to register at the various sites. Details of the second launch press event, which will be held in London (UK), will be available at a later date. Cluster II Competition Attracts Record Entries. A highlight of the first launch event at ESOC will be the announcement of the overall winner of ESA's "Name the Cluster quartet" competition and the chosen names of the four Cluster II satellites. Last February, members of the public in all of ESA's 15 member states were asked to suggest the most suitable names for the Cluster II spacecraft. The satellites are currently known as flight models (FM) 5, 6, 7 and 8. Competitors were asked to propose a set of four names (places, people, or things from history, mythology, or fiction, but not living persons) and explain in a few sentences the reasons for their choice. After sifting through more than 5,000 entries from all over Europe and debating at length the merits of the various suggestions, the multinational jury eventually produced a list of 15 national prize winners - one

  9. Linnett Double Quartet Theory, Challenging the Pairing Electrons

    Directory of Open Access Journals (Sweden)

    Yeganeh Khaniani

    2009-01-01

    Full Text Available Linnett proposed his theory 45 years after Lewis's supposition. During these years Pauling, Mulliken and Hund made different molecular structure models based on valance bond and molecular orbital theory. Their theories were seemed to fit many experiences but had some inabilities. Linnett's double quartet theory could solved some important problems about stability of radicals, paramagnetism / diamagnetism in molecular systems, electronic structure in transition states and finally challenge of resonance and aromaticity. In this article we review some basic ideas and concepts concerning different models and then we give a detailed discussion of the LDQ and use it in diverse branches of chemistry.

  10. Perception of string quartet synchronization

    Science.gov (United States)

    Wing, Alan M.; Endo, Satoshi; Yates, Tim; Bradbury, Adrian

    2014-01-01

    of variance and the micro-structure of the time-series of the asynchronies caused by differences in correction gain when judging lack of togetherness in quartet performance. PMID:25352813

  11. A Pseudo-Boolean Solution to the Maximum Quartet Consistency Problem

    CERN Document Server

    Morgado, Antonio

    2008-01-01

    Determining the evolutionary history of a given biological data is an important task in biological sciences. Given a set of quartet topologies over a set of taxa, the Maximum Quartet Consistency (MQC) problem consists of computing a global phylogeny that satisfies the maximum number of quartets. A number of solutions have been proposed for the MQC problem, including Dynamic Programming, Constraint Programming, and more recently Answer Set Programming (ASP). ASP is currently the most efficient approach for optimally solving the MQC problem. This paper proposes encoding the MQC problem with pseudo-Boolean (PB) constraints. The use of PB allows solving the MQC problem with efficient PB solvers, and also allows considering different modeling approaches for the MQC problem. Initial results are promising, and suggest that PB can be an effective alternative for solving the MQC problem.

  12. Correlation matrix for quartet codon usage

    CERN Document Server

    Frappat, L; Sorba, Paul

    2005-01-01

    It has been argued that the sum of usage probabilities for codons, belonging to quartets, that have as third nucleotide C or A, is independent of the biological species for vertebrates. The comparison between the theoretical correlation matrix derived from these sum rules and the experimentally computed matrix for 26 species shows a satisfactory agreement. The Shannon entropy, weakly depending on the biological species, gives further support. Suppression of codons containing the dinucleotides CG or AU is put in evidence.

  13. The hippocampus is an integral part of the temporal limbic system during emotional processing. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Trost, Wiebke; Frühholz, Sascha

    2015-06-01

    The proposed quartet theory of human emotions by Koelsch and colleagues [1] identifies four different affect systems to be involved in the processing of particular types of emotions. Moreover, the theory integrates both basic emotions and more complex emotion concepts, which include also aesthetic emotions such as musical emotions. The authors identify a particular brain system for each kind of emotion type, also by contrasting them to brain structures that are generally involved in emotion processing irrespective of the type of emotion. A brain system that has been less regarded in emotion theories, but which represents one of the four systems of the quartet to induce attachment related emotions, is the hippocampus.

  14. Quartet unconstrained formulation for massless higher spin fields

    Science.gov (United States)

    Buchbinder, I. L.; Galajinsky, A. V.; Krykhtin, V. A.

    2007-09-01

    We construct simple unconstrained Lagrangian formulations for massless higher spin fields in flat space of arbitrary dimension and on anti-de Sitter background. Starting from the triplet equations of Francia and Sagnotti, which describe a chain of spin modes, we introduce an auxiliary field and find appropriate gauge invariant constraints that single out the spin- s mode. The resulting quartet of fields, thus describing an irreducible representation of the Poincaré group, is used to construct simple Lagrangian formulations, which are local, free from higher derivative terms and use equal number of auxiliary fields for an unconstrained description of any value of spin. Our method proves to be most efficient for an unconstrained description of massless higher spin fermions in anti-de Sitter space. A relation of the minimal models with the universal BRST approach is discussed.

  15. Quartet unconstrained formulation for massless higher spin fields

    CERN Document Server

    Buchbinder, I L; Krykhtin, V A

    2007-01-01

    We construct simple unconstrained Lagrangian formulations for massless higher spin fields in flat space of arbitrary dimension and on anti de Sitter background. Starting from the triplet equations of Francia and Sagnotti, which describe a chain of spin modes, we introduce an auxiliary field and find appropriate gauge invariant constraints that single out the spin-s mode. The resulting quartet of fields, thus describing an irreducible representation of the Poincare group, is used to construct simple Lagrangian formulations, which are local, free from higher derivative terms and use equal number of auxiliary fields for an unconstrained description of any value of spin. Our method proves to be most efficient for an unconstrained description of massless higher spin fermions in anti de Sitter space. A relation of the minimal models with the universal BRST approach is discussed.

  16. Quartet decomposition server: a platform for analyzing phylogenetic trees

    Directory of Open Access Journals (Sweden)

    Mao Fenglou

    2012-06-01

    Full Text Available Abstract Background The frequent exchange of genetic material among prokaryotes means that extracting a majority or plurality phylogenetic signal from many gene families, and the identification of gene families that are in significant conflict with the plurality signal is a frequent task in comparative genomics, and especially in phylogenomic analyses. Decomposition of gene trees into embedded quartets (unrooted trees each with four taxa is a convenient and statistically powerful technique to address this challenging problem. This approach was shown to be useful in several studies of completely sequenced microbial genomes. Results We present here a web server that takes a collection of gene phylogenies, decomposes them into quartets, generates a Quartet Spectrum, and draws a split network. Users are also provided with various data download options for further analyses. Each gene phylogeny is to be represented by an assessment of phylogenetic information content, such as sets of trees reconstructed from bootstrap replicates or sampled from a posterior distribution. The Quartet Decomposition server is accessible at http://quartets.uga.edu. Conclusions The Quartet Decomposition server presented here provides a convenient means to perform Quartet Decomposition analyses and will empower users to find statistically supported phylogenetic conflicts.

  17. Quartet decomposition server: a platform for analyzing phylogenetic trees.

    Science.gov (United States)

    Mao, Fenglou; Williams, David; Zhaxybayeva, Olga; Poptsova, Maria; Lapierre, Pascal; Gogarten, J Peter; Xu, Ying

    2012-06-07

    The frequent exchange of genetic material among prokaryotes means that extracting a majority or plurality phylogenetic signal from many gene families, and the identification of gene families that are in significant conflict with the plurality signal is a frequent task in comparative genomics, and especially in phylogenomic analyses. Decomposition of gene trees into embedded quartets (unrooted trees each with four taxa) is a convenient and statistically powerful technique to address this challenging problem. This approach was shown to be useful in several studies of completely sequenced microbial genomes. We present here a web server that takes a collection of gene phylogenies, decomposes them into quartets, generates a Quartet Spectrum, and draws a split network. Users are also provided with various data download options for further analyses. Each gene phylogeny is to be represented by an assessment of phylogenetic information content, such as sets of trees reconstructed from bootstrap replicates or sampled from a posterior distribution. The Quartet Decomposition server is accessible at http://quartets.uga.edu. The Quartet Decomposition server presented here provides a convenient means to perform Quartet Decomposition analyses and will empower users to find statistically supported phylogenetic conflicts.

  18. Isobaric multiplet mass equation in the A =31 ,T =3 /2 quartets

    Science.gov (United States)

    Bennett, M. B.; Wrede, C.; Brown, B. A.; Liddick, S. N.; Pérez-Loureiro, D.; Bardayan, D. W.; Chen, A. A.; Chipps, K. A.; Fry, C.; Glassman, B. E.; Langer, C.; Larson, N. R.; McNeice, E. I.; Meisel, Z.; Ong, W.; O'Malley, P. D.; Pain, S. D.; Prokop, C. J.; Schwartz, S. B.; Suchyta, S.; Thompson, P.; Walters, M.; Xu, X.

    2016-06-01

    Background: The observed mass excesses of analog nuclear states with the same mass number A and isospin T can be used to test the isobaric multiplet mass equation (IMME), which has, in most cases, been validated to a high degree of precision. A recent measurement [Kankainen et al., Phys. Rev. C 93, 041304(R) (2016), 10.1103/PhysRevC.93.041304] of the ground-state mass of 31Cl led to a substantial breakdown of the IMME for the lowest A =31 ,T =3 /2 quartet. The second-lowest A =31 ,T =3 /2 quartet is not complete, due to uncertainties associated with the identity of the 31S member state. Purpose: Our goal is to populate the two lowest T =3 /2 states in 31S and use the data to investigate the influence of isospin mixing on tests of the IMME in the two lowest A =31 ,T =3 /2 quartets. Methods: Using a fast 31Cl beam implanted into a plastic scintillator and a high-purity Ge γ -ray detection array, γ rays from the 31Cl(β γ )31S sequence were measured. Shell-model calculations using USDB and the recently-developed USDE interactions were performed for comparison. Results: Isospin mixing between the 31S isobaric analog state (IAS) at 6279.0(6) keV and a nearby state at 6390.2(7) keV was observed. The second T =3 /2 state in 31S was observed at Ex=7050.0 (8 ) keV. Calculations using both USDB and USDE predict a triplet of isospin-mixed states, including the lowest T =3 /2 state in 31P, mirroring the observed mixing in 31S, and two isospin-mixed triplets including the second-lowest T =3 /2 states in both 31S and 31P. Conclusions: Isospin mixing in 31S does not by itself explain the IMME breakdown in the lowest quartet, but it likely points to similar isospin mixing in the mirror nucleus 31P, which would result in a perturbation of the 31P IAS energy. USDB and USDE calculations both predict candidate 31P states responsible for the mixing in the energy region slightly above Ex=6400 keV. The second quartet has been completed thanks to the identification of the second 31S T

  19. Searching for the one and many emotional brains. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Armony, Jorge L.

    2015-06-01

    Over the past hundred years or so, several neurally-based, or at least neurally-inspired, models of emotion have been proposed, with varying degrees of acceptance and success. Early ones were mostly based on data obtained from experiments conducted in non-human animals using classical conditioning paradigms, thus focusing on defensive (threat) and appetitive (reward) behaviors. Some features of the models were sometimes confirmed as being also applicable to humans, usually in experiments with patients suffering from focal brain lesions - although inconsistent, or even contradictory findings were often reported.

  20. Can modular psychological concepts like affect and emotion be assigned to a distinct subset of regional neural circuits?. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Fehr, Thorsten; Herrmann, Manfred

    2015-06-01

    The proposed Quartet Theory of Human Emotions by Koelsch and co-workers [11] adumbrates evidence from various scientific sources to integrate and assign the psychological concepts of 'affect' and 'emotion' to four brain circuits or to four neuronal core systems for affect-processing in the brain. The authors differentiate between affect and emotion and assign several facultative, or to say modular, psychological domains and principles of information processing, such as learning and memory, antecedents of affective activity, emotion satiation, cognitive complexity, subjective quality feelings, degree of conscious appraisal, to different affect systems. Furthermore, they relate orbito-frontal brain structures to moral affects as uniquely human, and the hippocampus to attachment-related affects. An additional feature of the theory describes 'emotional effector-systems' for motor-related processes (e.g., emotion-related actions), physiological arousal, attention and memory that are assumed to be cross-linked with the four proposed affect systems. Thus, higher principles of emotional information processing, but also modular affect-related issues, such as moral and attachment related affects, are thought to be handled by these four different physiological sub-systems that are on the other side assumed to be highly interwoven at both physiological and functional levels. The authors also state that the proposed sub-systems have many features in common, such as the selection and modulation of biological processes related to behaviour, perception, attention and memory. The latter aspect challenges an ongoing discussion about the mind-body problem: To which degree do the proposed sub-systems 'sufficiently' cover the processing of complex modular or facultative emotional/affective and/or cognitive phenomena? There are current models and scientific positions that almost completely reject the idea that modular psychological phenomena are handled by a distinct selection of

  1. Telemann. Musique de table - Quartet in E minor / Anderson, Nicholas

    Index Scriptorium Estoniae

    Anderson, Nicholas

    1995-01-01

    Uuest heliplaadist "Telemann. Musique de table - Quartet in E minor. Paris Quartets. "Nouveaux quatuors en six suites" - Nr. 1 in D, TWV43: D3, Nr. 2 in A minor, TWV43: a2. Six Concerts et Six Suites - Concert Nr. 3 in A, TWV42: A3. Hortus Musicus (Neeme Punder (fl.), Imbi Tarum (hpd.), Peeter Klaas (va da gamba), Tarmo Toom (vc) / Andres Mustonen (vn). Finlandia CD 4509-95578-2 (52 minutes)

  2. Telemann. Musique de table - Quartet in E minor / Anderson, Nicholas

    Index Scriptorium Estoniae

    Anderson, Nicholas

    1995-01-01

    Uuest heliplaadist "Telemann. Musique de table - Quartet in E minor. Paris Quartets. "Nouveaux quatuors en six suites" - Nr. 1 in D, TWV43: D3, Nr. 2 in A minor, TWV43: a2. Six Concerts et Six Suites - Concert Nr. 3 in A, TWV42: A3. Hortus Musicus (Neeme Punder (fl.), Imbi Tarum (hpd.), Peeter Klaas (va da gamba), Tarmo Toom (vc) / Andres Mustonen (vn). Finlandia CD 4509-95578-2 (52 minutes)

  3. The difference between emotion and affect. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Cochrane, Tom

    2015-06-01

    Koelsch and colleagues have produced a fascinating model that convincingly argues for the existence of four neuroanatomically distinct systems involved in our emotions. As I understood it, the claim was that these systems build upon each other, each one introducing a new sophistication that allows a distinct class of emotional states to emerge. For instance, the hippocampus enables the generation of emotions related to long-term attachment as opposed to simple reward and punishment [1, Section 2.3.2]. However, it was uncertain why we should stop at four affect systems. Many different brain structures contribute an additional sophistication to emotional function; could there not be a class of emotions associated with each of these sophistications? How distinctive does the new function, or the new class of emotions have to be to qualify? Should we be on the lookout for neural structures associated with meta-emotions [2] or epistemic emotions [3] as well?

  4. Regulating with imagery and the complexity of basic emotions. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Meyer, Marcel; Kuchinke, Lars

    2015-06-01

    Literature, music and the arts have long attested to the complexity of human emotions. Hitherto, psychological and biological theories of emotions have largely neglected this rich heritage. In their review Koelsch and colleagues [1] have embarked upon the pioneering endeavour of integrating the diverse perspectives in emotion research. Noting that the focus of prior neurobiological theories relies mainly on animal studies, the authors sought to complement this body of research with a model of complex ("moral") emotions in humans (henceforth: complex emotions). According to this novel framework, there are four main interacting affective centres in the brain. Each centre is associated with a dominant affective function, such as ascending activation (brainstem), pain/pleasure (diencephalon), attachment-related affects (hippocampus) or moral emotions and unconscious cognitive appraisal (orbitofrontal cortex). Furthermore, language is ascribed a key role in (a) the communication of subjective feeling (reconfiguration) and (b) in the conscious regulation of emotions (by means of logic and rational thought).

  5. Cluster II quartet take the stage together

    Science.gov (United States)

    1999-11-01

    This is the only occasion on which all four of ESA's Cluster II spacecraft will be on display together in Europe. Four Spacecraft, One Mission The unique event takes place near the end of the lengthy assembly and test programme, during which each individual spacecraft is being assembled in sequence, one after the other. Two have already completed their assembly and systems testing and are about to be stored in special containers at IABG prior to shipment to the Baikonur launch site in Kazakhstan next spring. In the case of the other two, flight models 5 and 8, installation of the science payloads has finished, but their exhaustive series of environmental tests at IABG have yet to begin. Following delivery to the launch site next April, the satellites will be launched in pairs in June and July 2000. Two Soyuz rockets, each with a newly designed Fregat upper stage, are being provided by the Russian-French Starsem company. This will be the first time ESA satellites have been launched from the former Soviet Union. Cluster II is a replacement for the original Cluster mission, which was lost during the maiden launch of Ariane 5 in June 1996. ESA, given the mission's importance in its overall strategy in the area of the Sun-Earth connection, decided to rebuild this unique project. ESA member states supported that proposal. On 3 April 1997, the Agency's Science Programme Committee agreed. Cluster II was born. European Teamwork Scientific institutions and industrial enterprises in almost all the 14 ESA member states and the United States are taking part in the Cluster II project. Construction of the eight Cluster / Cluster II spacecraft has been a major undertaking for European industry. Built into each 1200 kg satellite are six propellant tanks, two pressure tanks, eight thrusters, 80 metres of pipework, about 5 km of wiring, 380 connectors and more than 14 000 electrical contacts. All the spacecraft were assembled in the giant clean room at the Friedrichshafen plant of

  6. Computing the Quartet Distance Between Evolutionary Trees in Time O(n log n)

    DEFF Research Database (Denmark)

    Brodal, Gerth Sølfting; Fagerberg, Rolf; Pedersen, Christian Nørgaard Storm

    2003-01-01

    Morris, and Meacham. The quartet distance between two unrooted evolutionary trees is the number of quartet topology differences between the two trees, where a quartet topology is the topological subtree induced by four species. In this paper we present an algorithm for computing the quartet distance between two...... unrooted evolutionary trees of n species, where all internal nodes have degree three, in time O(n log n. The previous best algorithm for the problem uses time O(n 2)....

  7. Reconstructing phylogenies from noisy quartets in polynomial time with a high success probability

    Directory of Open Access Journals (Sweden)

    Wu Gang

    2008-01-01

    Full Text Available Abstract Background In recent years, quartet-based phylogeny reconstruction methods have received considerable attentions in the computational biology community. Traditionally, the accuracy of a phylogeny reconstruction method is measured by simulations on synthetic datasets with known "true" phylogenies, while little theoretical analysis has been done. In this paper, we present a new model-based approach to measuring the accuracy of a quartet-based phylogeny reconstruction method. Under this model, we propose three efficient algorithms to reconstruct the "true" phylogeny with a high success probability. Results The first algorithm can reconstruct the "true" phylogeny from the input quartet topology set without quartet errors in O(n2 time by querying at most (n - 4 log(n - 1 quartet topologies, where n is the number of the taxa. When the input quartet topology set contains errors, the second algorithm can reconstruct the "true" phylogeny with a probability approximately 1 - p in O(n4 log n time, where p is the probability for a quartet topology being an error. This probability is improved by the third algorithm to approximately 11+q2+12q4+116q5 MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGacaGaaiaabeqaaeqabiWaaaGcbaqcfa4aaSaaaeaacqaIXaqmaeaacqaIXaqmcqGHRaWkcqWGXbqCdaahaaqabeaacqaIYaGmaaGaey4kaSYaaSaaaeaacqaIXaqmaeaacqaIYaGmaaGaemyCae3aaWbaaeqabaGaeGinaqdaaiabgUcaRmaalaaabaGaeGymaedabaGaeGymaeJaeGOnaydaaiabdghaXnaaCaaabeqaaiabiwda1aaaaaaaaa@3D5A@, where q=p1−p MathType@MTEF@5@5@+=feaagaart1ev2aaatCvAUfKttLearuWrP9MDH5MBPbIqV92AaeXatLxBI9gBaebbnrfifHhDYfgasaacPC6xNi=xH8viVGI8Gi=hEeeu0xXdbba9frFj0xb9qqpG0dXdb9aspeI8k8fiI+fsY=rqGqVepae9pg0db9vqaiVgFr0xfr=xfr=xc9adbaqaaeGacaGaaiaabeqaaeqabiWaaaGcbaGaemyCaeNaeyypa0tcfa4aaSaaaeaacqWGWbaCaeaacqaIXaqmcqGHsislcqWGWbaCaaaaaa@3391@, with

  8. String Quartets as Self-Managed Teams: An Interdisciplinary Perspective

    Science.gov (United States)

    Gilboa, Avi; Tal-Shmotkin, Malka

    2012-01-01

    This article examines empirically and systematically whether a string quartet (SQ) ensemble is perceived as a self-managed team (SMT). SMTs, which were initially employed in the industrial world, are groups of employees that have a total responsibility for a defined project. The hypothesis that the SQ would exhibit more typical SMT characteristics…

  9. String Quartets as Self-Managed Teams: An Interdisciplinary Perspective

    Science.gov (United States)

    Gilboa, Avi; Tal-Shmotkin, Malka

    2012-01-01

    This article examines empirically and systematically whether a string quartet (SQ) ensemble is perceived as a self-managed team (SMT). SMTs, which were initially employed in the industrial world, are groups of employees that have a total responsibility for a defined project. The hypothesis that the SQ would exhibit more typical SMT characteristics…

  10. Efficient Quartet Representations of Trees and Applications to Supertree and Summary Methods.

    Science.gov (United States)

    Davidson, Ruth; Lawhorn, MaLyn; Rusinko, Joseph; Weber, Noah

    2016-12-14

    Quartet trees displayed by larger phylogenetic trees have long been used as inputs for species tree and supertree reconstruction. Computational constraints prevent the use of all displayed quartets in many practical problems with large numbers of taxa. We introduce the notion of an Efficient Quartet System (EQS) to represent a phylogenetic tree with a subset of the quartets displayed by the tree. We show mathematically that the set of quartets obtained from a tree via an EQS contains all of the combinatorial information of the tree itself. Using performance tests on simulated datasets, we also demonstrate that using an EQS to reduce the number of quartets in both summary method pipelines for species tree inference as well as methods for supertree inference results in only small reductions in accuracy.

  11. Isobaric multiplet mass equation in the $A=31$ $T = 3/2$ quartets

    CERN Document Server

    Bennett, M B; Brown, B A; Liddick, S N; Pérez-Loureiro, D; Bardayan, D W; Chen, A A; Chipps, K A; Fry, C; Glassman, B E; Langer, C; Larson, N R; McNeice, E I; Meisel, Z; Ong, W; O'Malley, P D; Pain, S D; Prokop, C J; Schwartz, S B; Suchyta, S; Thompson, P; Walters, M; Xu, X

    2016-01-01

    The observed mass excesses of analog nuclear states with the same mass number $A$ and isospin $T$ can be used to test the isobaric multiplet mass equation (IMME), which has, in most cases, been validated to a high degree of precision. A recent measurement [Kankainen et al., Phys. Rev. C 93 041304(R) (2016)] of the ground-state mass of $^{31}$Cl led to a substantial breakdown of the IMME for the lowest $A = 31, T = 3/2$ quartet. The second-lowest $A = 31, T = 3/2$ quartet is not complete, due to uncertainties associated with the identity of the $^{31}$S member state. Using a fast $^{31}$Cl beam implanted into a plastic scintillator and a high-purity Ge $\\gamma$-ray detection array, $\\gamma$ rays from the $^{31}$Cl$(\\beta\\gamma)$$^{31}$S sequence were measured. Shell-model calculations using USDB and the recently-developed USDE interactions were performed for comparison. Isospin mixing between the $^{31}$S isobaric analog state (IAS) at 6279.0(6) keV and a nearby state at 6390.2(7) keV was observed. The second ...

  12. European Space Agency announces contest to "Name the Cluster Quartet"

    Science.gov (United States)

    2000-02-01

    1. Contest rules The European Space Agency (ESA) is launching a public competition to find the most suitable names for its four Cluster II space weather satellites. The quartet, which are currently known as flight models 5, 6, 7 and 8, are scheduled for launch from Baikonur Space Centre in Kazakhstan in June and July 2000. Professor Roger Bonnet, ESA Director of Science Programme, announced the competition for the first time to the European Delegations on the occasion of the Science Programme Committee (SPC) meeting held in Paris on 21-22 February 2000. The competition is open to people of all the ESA member states (*). Each entry should include a set of FOUR names (places, people, or things from history, mythology, or fiction, but NOT living persons). Contestants should also describe in a few sentences why their chosen names would be appropriate for the four Cluster II satellites. The winners will be those which are considered most suitable and relevant for the Cluster II mission. The names must not have been used before on space missions by ESA, other space organizations or individual countries. One winning entry per country will be selected to go to the Finals of the competition. The prize for each national winner will be an invitation to attend the first Cluster II launch event in mid-June 2000 with their family (4 persons) in a 3-day trip (including excursions to tourist sites) to one of these ESA establishments: ESRIN (near Rome, Italy): winners from France, Ireland, United Kingdom, Belgium. VILSPA (near Madrid, Spain): winners from The Netherlands, Norway, Sweden, Finland. ESTEC (near Amsterdam, The Netherlands): winners from Germany, Denmark, Switzerland, Austria. ESOC (in the Rhine Valley, Germany): winners from Italy, Spain , Portugal. During the first Cluster II launch event (June 2000) the chosen four names for the spacecraft will be announced. The grand prize will be: * a trip for the winner and family (4 people) to Paris where ESA's headquarters are

  13. Minimal quartet-metric gravity: beyond LCDM per scalar graviton as the unified dark matter and dark energy

    CERN Document Server

    Pirogov, Yury F

    2016-01-01

    In the framework of the minimal quartet-metric gravity/systogravity, a scalar graviton/systolon is stated as a universal dark component, with supplementary manifestations in the different contexts either as dark matter or dark energy. An ensuing extension to the standard {\\Lambda}CDM model is developed. A modification of the late expansion of the Universe, with an attractor of a scalar master equation defining an effective cosmological constant, which supersedes the true one, is proposed. A new partial solution to the cosmological constant problem is discussed.

  14. On the Interaction in a Quartet of Galaxies

    CERN Document Server

    Yeghiazaryan, A A; Nazaryan, T A

    2015-01-01

    We performed the Fabry-Perot scanning interferometry of the quartet of galaxies NGC 7769, 7770, 7771 and 7771A in Ha line and studied their velocity fields. We found that the rotation curve of NGC 7769 is weakly distorted. The rotation curve of NGC 7771 is strongly distorted with the tidal arms caused by direct flyby of NGC 7769 and flyby of a smaller neighbor NGC 7770. The rotation curve of NGC 7770 is significantly skewed because of the interaction with much massive NGC 7771. The rotation curves and morphological disturbances suggest that the NGC 7769 and NGC 7771 have passed the first pericenter stage, however, probably the second encounter has not happened yet.

  15. The music of earthquakes and Earthquake Quartet #1

    Science.gov (United States)

    Michael, Andrew J.

    2013-01-01

    Earthquake Quartet #1, my composition for voice, trombone, cello, and seismograms, is the intersection of listening to earthquakes as a seismologist and performing music as a trombonist. Along the way, I realized there is a close relationship between what I do as a scientist and what I do as a musician. A musician controls the source of the sound and the path it travels through their instrument in order to make sound waves that we hear as music. An earthquake is the source of waves that travel along a path through the earth until reaching us as shaking. It is almost as if the earth is a musician and people, including seismologists, are metaphorically listening and trying to understand what the music means.

  16. High-resolution tunnelling spectroscopy of a graphene quartet.

    Science.gov (United States)

    Song, Young Jae; Otte, Alexander F; Kuk, Young; Hu, Yike; Torrance, David B; First, Phillip N; de Heer, Walt A; Min, Hongki; Adam, Shaffique; Stiles, Mark D; MacDonald, Allan H; Stroscio, Joseph A

    2010-09-01

    Electrons in a single sheet of graphene behave quite differently from those in traditional two-dimensional electron systems. Like massless relativistic particles, they have linear dispersion and chiral eigenstates. Furthermore, two sets of electrons centred at different points in reciprocal space ('valleys') have this dispersion, giving rise to valley degeneracy. The symmetry between valleys, together with spin symmetry, leads to a fourfold quartet degeneracy of the Landau levels, observed as peaks in the density of states produced by an applied magnetic field. Recent electron transport measurements have observed the lifting of the fourfold degeneracy in very large applied magnetic fields, separating the quartet into integer and, more recently, fractional levels. The exact nature of the broken-symmetry states that form within the Landau levels and lift these degeneracies is unclear at present and is a topic of intense theoretical debate. Here we study the detailed features of the four quantum states that make up a degenerate graphene Landau level. We use high-resolution scanning tunnelling spectroscopy at temperatures as low as 10 mK in an applied magnetic field to study the top layer of multilayer epitaxial graphene. When the Fermi level lies inside the fourfold Landau manifold, significant electron correlation effects result in an enhanced valley splitting for even filling factors, and an enhanced electron spin splitting for odd filling factors. Most unexpectedly, we observe states with Landau level filling factors of 7/2, 9/2 and 11/2, suggestive of new many-body states in graphene.

  17. A sub-cubic time algorithm for computing the quartet distance between two general trees

    Directory of Open Access Journals (Sweden)

    Mailund Thomas

    2011-06-01

    Full Text Available Abstract Background When inferring phylogenetic trees different algorithms may give different trees. To study such effects a measure for the distance between two trees is useful. Quartet distance is one such measure, and is the number of quartet topologies that differ between two trees. Results We have derived a new algorithm for computing the quartet distance between a pair of general trees, i.e. trees where inner nodes can have any degree ≥ 3. The time and space complexity of our algorithm is sub-cubic in the number of leaves and does not depend on the degree of the inner nodes. This makes it the fastest algorithm so far for computing the quartet distance between general trees independent of the degree of the inner nodes. Conclusions We have implemented our algorithm and two of the best competitors. Our new algorithm is significantly faster than the competition and seems to run in close to quadratic time in practice.

  18. G-quartet type self-assembly of guanine functionalized single-walled carbon nanotubes

    Science.gov (United States)

    Singh, Prabhpreet; Venkatesh, V.; Nagapradeep, N.; Verma, Sandeep; Bianco, Alberto

    2012-03-01

    The simple strategy of linking guanine to single-walled carbon nanotubes (CNTs) through covalent functionalization permitted generation of the alignment of the nanotubes into lozenges reminiscent of guanine quartets (G-quartets) in the presence of potassium ions as observed by atomic force microscopy.The simple strategy of linking guanine to single-walled carbon nanotubes (CNTs) through covalent functionalization permitted generation of the alignment of the nanotubes into lozenges reminiscent of guanine quartets (G-quartets) in the presence of potassium ions as observed by atomic force microscopy. Electronic supplementary information (ESI) available: Experimental procedures for the synthesis and characterization of the precursors and MWCNT conjugates. See DOI: 10.1039/c2nr11849a

  19. New supersymmetric quartet of nuclei in the A=190 mass region

    CERN Document Server

    Barea, J; Frank, A; Graw, G; Hertenberger, R; Wirth, H F; Christen, S; Jolie, J; Tonev, D; Balodis, M; Berzins, J; Kramere, N; Von Egidy, T

    2008-01-01

    We present evidence for a new supersymmetric quartet in the A=190 region of the nuclear mass table. New experimental information on transfer and neutron capture reactions to the odd-odd nucleaus 194 Ir strongly suggests the existence of a new supersymmetric quartet, consisting of the 192,193 Os and 193,194 Ir nuclei. We make explicit predictions for the odd-neutron nucleus 193 Os, and suggest that its spectroscopic properties be measured in dedicated experiments.

  20. Visual Influences in Temporal Coordination of a String Quartet

    Directory of Open Access Journals (Sweden)

    Satoshi Endo

    2011-10-01

    Full Text Available In ensemble musical performance, players strive to generate synchronous onsets for notes that are supposed to be played together. Important cues for correcting phase are available in the acoustic onsets of notes, so that when a pair of players detects an asynchrony, the timing of the next note may be adjusted (Schulze, Cordes & Vorberg, 2005. However, such feedback correction only works in the body of the music and leaves unsolved the problem of how to synchronise entries such as at the beginning of a piece. In such cases vision can be a useful source of information as the movements of the players (eg bowing arm in string players in preparation for playing may allow others to predict the intended timing of the next note onset. In order to investigate the role of vision and audition in music ensemble, we prepared an avatar from a motion capture recording of the first violinist in a leading chamber group playing the opening of a Haydn quartet. We then selectively edited out the left and right arms and head. When the other three players were asked to play with the reduced cue avatar, we observed the variance of asynchrony was smallest with left arm absent, larger with head absent and highest with right arm absent. We conclude that bowing arm movements provide important cues to timing in chamber music performance. We suggest that this method has promise for investigating other aspects of visual cue utilisation in music.

  1. Aesthetic emotions to art - What they are and what makes them special. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Leder, Helmut; Markey, Patrick S.; Pelowski, Matthew

    2015-06-01

    Establishing a functional understanding of emotional processes is crucial for profound insight into human cognition and behavior [6]. The study of human interactions with art provides an excellent window into the complex emotional reactions that can be had with the environment. Recent advances in the empirical study of art reception have given rise to new models [8,9], and a growing interest in aesthetic affect and emotion.

  2. The Elusive Allocation of Responsibility to Informal Organizations: The Case of the Quartet on the Middle East

    NARCIS (Netherlands)

    Dugard, J.; Vermeer-Künzli, A.M.H.

    2013-01-01

    This paper considers the question of responsibility for omissions of the Quartet on the Middle East. The Quartet was created to assist in the peace process between Israel and Palestine. Its core document is the Roadmap, but in recent years it has failed to live up to its expectations and arguably th

  3. The elusive allocation of responsibility to informal organizations: the case of the Quartet on the Middle East

    NARCIS (Netherlands)

    Dugard, J.; Vermeer-Künzli, A.; Ragazzi, M.

    2013-01-01

    This paper considers the question of responsibility for omissions of the Quartet on the Middle East. The Quartet was created to assist in the peace process between Israel and Palestine. Its core document is the Roadmap, but in recent years it has failed to live up to its expectations and arguably th

  4. The Plausibility of a String Quartet Performance in Virtual Reality.

    Science.gov (United States)

    Bergstrom, Ilias; Azevedo, Sergio; Papiotis, Panos; Saldanha, Nuno; Slater, Mel

    2017-04-01

    We describe an experiment that explores the contribution of auditory and other features to the illusion of plausibility in a virtual environment that depicts the performance of a string quartet. 'Plausibility' refers to the component of presence that is the illusion that the perceived events in the virtual environment are really happening. The features studied were: Gaze (the musicians ignored the participant, the musicians sometimes looked towards and followed the participant's movements), Sound Spatialization (Mono, Stereo, Spatial), Auralization (no sound reflections, reflections corresponding to a room larger than the one perceived, reflections that exactly matched the virtual room), and Environment (no sound from outside of the room, birdsong and wind corresponding to the outside scene). We adopted the methodology based on color matching theory, where 20 participants were first able to assess their feeling of plausibility in the environment with each of the four features at their highest setting. Then five times participants started from a low setting on all features and were able to make transitions from one system configuration to another until they matched their original feeling of plausibility. From these transitions a Markov transition matrix was constructed, and also probabilities of a match conditional on feature configuration. The results show that Environment and Gaze were individually the most important factors influencing the level of plausibility. The highest probability transitions were to improve Environment and Gaze, and then Auralization and Spatialization. We present this work as both a contribution to the methodology of assessing presence without questionnaires, and showing how various aspects of a musical performance can influence plausibility.

  5. New supersymmetric quartet of nuclei: 192Os, 193Os, 193Ir, 194Ir

    CERN Document Server

    Bijker, R; Frank, A; Graw, G; Hertenberger, R; Jolie, J; Wirth, H -F

    2008-01-01

    We present evidence of the existence of a new supersymmetric quartet of nuclei in the A=190 mass region. The analysis is based on new experimental information on the odd-odd nucleus 194Ir from transfer and capture reactions. The new data allow the identification of a new supersymmetric quartet, consisting of the 192,193Os and 193,194Ir nuclei. We make explicit predictions fo r193Os, and suggest that its spectroscopic properties be measured in dedicated experiments. Finally, we study correlations between different transfer reactions.

  6. Reflections on Working with a String Quartet in Aesthetic Music Therapy

    Directory of Open Access Journals (Sweden)

    Colin Andrew Lee

    2003-11-01

    Full Text Available Aesthetic Music Therapy (AeMT is a music centred approach to clinical practice. This essay describes the beginning experiences of sessions with a professional string quartet. Using clinical improvisation the therapist and quartet explored inter-musical and inter-personal relationships. Questioning the importance of musical quality in clinical improvisation this paper proceeds to examine the parameters of clinical practice with musicians. Through the therapist's reflections on the inspirational aspects of sessions, questions are raised for future work and research.

  7. Brahms J. Piano Quartet No 1 in G minor, Op. 25 (orch. Schoenberg) / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1991-01-01

    Uuest heliplaadist "Brahms J. Piano Quartet No 1 in G minor, Op. 25 (orch. Schoenberg). Variations and Fugue on a Theme by Händel, Op. 24 (orch, Rubbra). London Symphony Orchestra /Neeme Järvi" Chandos ABTD 1450; CD CHAN 8825 (71 minutes)

  8. -Stacking interactions between G-quartets and circulenes: A computational study

    Indian Academy of Sciences (India)

    A K Jissy; J H V Ramana; Ayan Datta

    2011-11-01

    Structures of planar and bowl-shaped circulenes as well as their stacks with G-quartet (G4) have been investigated through dispersion-corrected Density Functional Theory (DFT-D). The binding energies are substantial ∼10 kcal/mol with d ∼3.5 Å between the stacking rings. The calculations show that G4 binds much more effectively to planar circulenes as compared to bowl shaped molecules. The strength of binding between a G-quartet and a non-planar circulene molecule depends on the orientation of the circulene (concave or convex) with respect to G-quartet. An AIM analysis of the M05-2X wave-functions has also been performed to confirm the presence of weak intermolecular interactions between guanine quartets and circulenes. Apart from -stacking interactions, the concave bowl-shaped circulenes also interact with G4 through C-H $\\cdots$ interactions. The charge transport properties between the two moieties have also been analysed through effective transport integral. The calculations provide an understanding for the basis of molecular recognition by G4 for non-planar systems.

  9. Brahms J. Piano Quartet No 1 in G minor, Op. 25 (orch. Schoenberg) / Jonathan Swain

    Index Scriptorium Estoniae

    Swain, Jonathan

    1991-01-01

    Uuest heliplaadist "Brahms J. Piano Quartet No 1 in G minor, Op. 25 (orch. Schoenberg). Variations and Fugue on a Theme by Händel, Op. 24 (orch, Rubbra). London Symphony Orchestra /Neeme Järvi" Chandos ABTD 1450; CD CHAN 8825 (71 minutes)

  10. A sub-cubic time algorithm for computing the quartet distance between two general trees

    DEFF Research Database (Denmark)

    Nielsen, Jesper; Kristensen, Anders Kabell; Mailund, Thomas;

    2011-01-01

    derived a new algorithm for computing the quartet distance between a pair of general trees, i.e. trees where inner nodes can have any degree ≥ 3. The time and space complexity of our algorithm is sub-cubic in the number of leaves and does not depend on the degree of the inner nodes. This makes...

  11. Efficient Algorithms for Computing the Triplet and Quartet Distance Between Trees of Arbitrary Degree

    DEFF Research Database (Denmark)

    Brodal, Gerth Stølting; Fagerberg, Rolf; Mailund, Thomas

    2013-01-01

    degree of any node in the two trees. Within the same time bounds, our framework also allows us to compute the parameterized triplet and quartet distances, where a parameter is introduced to weight resolved (binary) topologies against unresolved (non-binary) topologies. The previous best algorithm...

  12. The Effect of Body Movement on Listeners' Perceptions of Musicality in Trombone Quartet Performance

    Science.gov (United States)

    Silveira, Jason M.

    2014-01-01

    The purpose of this study was to determine what effect body movement would have on listeners' (N = 90) perceptions of a professional chamber ensemble performance. Specifically, an audio/video recording of a trombone quartet performance was used for the music stimulus. Listeners were asked to rate each performance on the basis of perceived…

  13. The Use of Video Analysis and the Knowledge Quartet in Mathematics Teacher Education Programmes

    Science.gov (United States)

    Liston, Miriam

    2015-01-01

    This study investigates the potential of video analysis and a mathematical knowledge for teaching framework, the Knowledge Quartet (KQ), in mathematics teacher education programmes. It reports on the effectiveness of these tools in analysing and supporting secondary level pre-service mathematics teachers' subject matter knowledge and pedagogical…

  14. Identifying recombinants in human and primate immunodeficiency virus sequence alignments using quartet scanning

    Directory of Open Access Journals (Sweden)

    Martin Darren P

    2009-04-01

    Full Text Available Abstract Background Recombination has a profound impact on the evolution of viruses, but characterizing recombination patterns in molecular sequences remains a challenging endeavor. Despite its importance in molecular evolutionary studies, identifying the sequences that exhibit such patterns has received comparatively less attention in the recombination detection framework. Here, we extend a quartet-mapping based recombination detection method to enable identification of recombinant sequences without prior specifications of either query and reference sequences. Through simulations we evaluate different recombinant identification statistics and significance tests. We compare the quartet approach with triplet-based methods that employ additional heuristic tests to identify parental and recombinant sequences. Results Analysis of phylogenetic simulations reveal that identifying the descendents of relatively old recombination events is a challenging task for all methods available, and that quartet scanning performs relatively well compared to the triplet based methods. The use of quartet scanning is further demonstrated by analyzing both well-established and putative HIV-1 recombinant strains. In agreement with recent findings, we provide evidence that the presumed circulating recombinant CRF02_AG is a 'pure' lineage, whereas the presumed parental lineage subtype G has a recombinant origin. We also demonstrate HIV-1 intrasubtype recombination, confirm the hybrid origin of SIV in chimpanzees and further disentangle the recombinant history of SIV lineages in a primate immunodeficiency virus data set. Conclusion Quartet scanning makes a valuable addition to triplet-based methods for identifying recombinant sequences without prior specifications of either query and reference sequences. The new method is available in the VisRD v.3.0 package http://www.cmp.uea.ac.uk/~vlm/visrd.

  15. Woman’s Celibacy:Power or Alienation? Feminist Concerns in A.S. Byatt’s Quartet

    Institute of Scientific and Technical Information of China (English)

    LI Dai

    2015-01-01

    As one of the most famous contemporary British women novelists, A.S. Byatt depicts the true situation of women in her“Frederica Quartet”. The quartet involves some feminist issues such as marriage and celibacy, female power and women ’s alienation. In the quartet, Byatt associates the mythical virgin images to the women figures in real life, and contemplates possible ways for women to survive and keep female power in a male-dominated society. It makes a detailed analysis on the recurring vir⁃gin images and the characterization of female characters in the quartet, aiming to analyze the theme of Byatt ’s quartet and reveal her feminist concerns.

  16. Haydn, by Villa-Lobos: an analysis of 1st movement of Villa-Lobos's String Quartet #7

    OpenAIRE

    2012-01-01

    Este estudo analisa o 1º movimento do Quarteto de Cordas nº 7 de Villa-Lobos e investiga possíveis referências aos quartetos de cordas compostos por Franz Haydn, como Villa-Lobos sugeriu a Arnaldo Estrella.This article analyses the 1st movement of Villa-Lobos' String Quartet nº 7 and search for possible references to Franz Haydn's string quartets, as suggested by Villa-Lobos in conversations with Arnaldo Estrella.

  17. Ghost-gluon and ghost-quark bound states and their role in BRST quartets

    CERN Document Server

    Alkofer, Natalia

    2011-01-01

    A non-perturbative version of the BRST quartet mechanism in infrared Landau gauge QCD is proposed for transverse gluons and quarks. Based on the positivity violation for transverse gluons the content of the respective non-perturbative BRST quartet is derived. To identify the gluon's BRST-daughter and second parent state, a truncated Bethe-Salpeter equation for the gluon-(anti-)ghost bound state is investigated. We comment shortly on several equivalent forms of this equation. Repeating the same construction for quarks leads to a truncated Bethe-Salpeter equation for a fundamentally charged quark-(anti-)ghost bound state. It turns out that a cardinal input to this equation is given by the fully dressed quark-gluon vertex, and that it is indispensable to dress the quark-gluon vertex in this equation in order to obtain a consistent truncation.

  18. Olivier Messiaen's quartet for the end of time, secret of form: Movement VI

    Directory of Open Access Journals (Sweden)

    Maksimović Svetlana

    2005-01-01

    Full Text Available Knowing that Messiaen's early period, especially The Quartet for the End of Time, got so many written comments and discussions and from renowned critics, musicologists and composers it is hard to believe that anything different could possibly come out about the structure, form or concept in his work. Still, another look at these works would be valuable, since the concept of form is far from explored. The focal point of this text is the sixth movement from the Quartet and its concept of form. It unveils the relation between Messiaen's music ideas and the ancient Greek tragedy and the depth of the influence that Greek art had on his concept of form. The influence goes as far as the "suggestion of ring composition".

  19. Dissociative excitation of the manganese atom quartet levels by collisions e-MnBr2

    Science.gov (United States)

    Smirnov, Yu M.

    2017-04-01

    Dissociative excitation of quartet levels of the manganese atom was studied in collisions of electrons with manganese dibromide molecules. Eighty-two cross-sections for transitions originating at odd levels and eleven cross-sections for transitions originating at even levels have been measured at an incident electron energy of 100 eV. An optical excitation function has been recorded in the electron energy range of 0–100 eV for transitions originating from 3d 64p z 4 F° levels. For the majority of transitions, a comparison of the resulting cross-section values to cross-sections produced by direct excitation is provided.

  20. Synchronization and leadership in string quartet performance: a case study of auditory and visual cues

    Directory of Open Access Journals (Sweden)

    Renee eTimmers

    2014-06-01

    Full Text Available Temporal coordination between members of a string quartet was investigated across repeated performances of an excerpt of Haydn’s string quartet in G Major, Op. 77 No. 1. Cross-correlations between interbeat intervals of performances at different lags showed a unidirectional dependence of Viola on Violin I, and of Violin I on Cello. Bidirectional dependence was observed for the relationships between Violin II and Cello and Violin II and Viola. Own-reported dependencies after the performances reflected these measured dependencies more closely than dependencies of players reported by the other players, which instead showed more typical leader-follower patterns in which Violin I leads. On the other hand, primary leadership from Violin I was observed in an analysis of the bow speed characteristics preceding the first tone onset. The anticipatory movement of Violin I set the tempo of the excerpt. Taken together the results show a more complex and differentiated pattern of dependencies than expected from a traditional role division of leadership suggesting several avenues for further research.

  1. Herbig Ae/Be candidate stars in the innermost Galactic disk: Quartet cluster

    CERN Document Server

    Yasui, Chikako; Hamano, Satoshi; Kondo, Sohei; Izumi, Natsuko; Saito, Masao; Tokunaga, Alan T

    2016-01-01

    In order to investigate the Galactic-scale environmental effects on the evolution of protoplanetary disks, we explored the near-infrared (NIR) disk fraction of the Quartet cluster, which is a young cluster in the innermost Galactic disk at the Galactocentric radius Rg ~ 4 kpc. Because this cluster has a typical cluster mass of ~10^3 M_sun as opposed to very massive clusters, which have been observed in previous studies (>10^4 M_sun), we can avoid intra-cluster effects such as strong UV field from OB stars. Although the age of the Quartet is previously estimated to be 3-8 Myr old, we find that it is most likely ~3-4.5 Myr old. In moderately deep JHK images from the UKIDSS survey, we found eight HAeBe candidates in the cluster, and performed K-band medium-resolution ($R \\equiv \\Delta \\lambda / \\lambda ~ 800$) spectroscopy for three of them with the Subaru 8.2 m telescope. These are found to have both Br\\gamma absorption lines as well as CO bandhead emission, suggesting that they are HAeBe stars with protoplanet...

  2. On the Scalability of Computing Triplet and Quartet Distances

    DEFF Research Database (Denmark)

    Holt, Morten Kragelund; Johansen, Jens; Brodal, Gerth Stølting

    2014-01-01

    We present the first I/O- and practically-efficient algorithm for simplifying a planar subdivision, such that no point is moved more than a given distance εxy and such that neighbor relations between faces (homotopy) are preserved. Under some practically realistic assumptions, our algorithm uses...... (SORT(N)) I/Os, where N is the size of the decomposition and SORT(N) is the number of I/Os need to sort in the standard external-memory model of computation. Previously, such an algorithm was only known for the special case of contour map simplification. Our algorithm is simple enough to be of practical...... interest. In fact, although more general, it is significantly simpler than the previous contour map simplification algorithm. We have implemented our algorithm and present results of experimenting with it on massive real-life data. The experiments confirm that the algorithm is efficient in practice...

  3. The use of video analysis and the Knowledge Quartet in mathematics teacher education programmes

    Science.gov (United States)

    Liston, Miriam

    2015-01-01

    This study investigates the potential of video analysis and a mathematical knowledge for teaching framework, the Knowledge Quartet (KQ), in mathematics teacher education programmes. It reports on the effectiveness of these tools in analysing and supporting secondary level pre-service mathematics teachers' subject matter knowledge and pedagogical content knowledge. This paper describes how a videotaped lesson of one pre-service teacher, teaching a class of mature students, was analysed and makes comparisons between the teacher educators' and the pre-service teacher's observations. Inter-rater reliability was investigated and a Kappa coefficient of .72 indicated substantial agreement between both coders. Findings are presented and implications of the use of video and the KQ for mathematics teacher education are drawn.

  4. Quartet-metric general relativity: scalar graviton, dark matter, and dark energy

    Energy Technology Data Exchange (ETDEWEB)

    Pirogov, Yury F. [SRC Institute for High Energy Physics of NRC Kurchatov Institute, Protvino (Russian Federation)

    2016-04-15

    General relativity extended through a dynamical scalar quartet is proposed as a theory of the scalar-vector-tensor gravity, generically describing the unified gravitational dark matter (DM) and dark energy (DE). The implementation in the weak-field limit of the Higgs mechanism for the extended gravity, with a redefinition of metric field, is exposed in a generally covariant form. Under a natural restriction on the parameters, the redefined theory possesses in the linearized approximation a residual transverse-diffeomorphism invariance, and consistently comprises the massless tensor graviton and a massive scalar one as a DM particle. The number of adjustable parameters in the full nonlinear theory and a partial decoupling of the latter from its weak-field limit noticeably extend the perspectives for the unified description of the gravity DM and DE in the various phenomena at the different scales. (orig.)

  5. Scale-Free Brain Quartet: Artistic Filtering of Multi-Channel Brainwave Music

    Science.gov (United States)

    Wu, Dan; Li, Chaoyi; Yao, Dezhong

    2013-01-01

    To listen to the brain activities as a piece of music, we proposed the scale-free brainwave music (SFBM) technology, which translated scalp EEGs into music notes according to the power law of both EEG and music. In the present study, the methodology was extended for deriving a quartet from multi-channel EEGs with artistic beat and tonality filtering. EEG data from multiple electrodes were first translated into MIDI sequences by SFBM, respectively. Then, these sequences were processed by a beat filter which adjusted the duration of notes in terms of the characteristic frequency. And the sequences were further filtered from atonal to tonal according to a key defined by the analysis of the original music pieces. Resting EEGs with eyes closed and open of 40 subjects were utilized for music generation. The results revealed that the scale-free exponents of the music before and after filtering were different: the filtered music showed larger variety between the eyes-closed (EC) and eyes-open (EO) conditions, and the pitch scale exponents of the filtered music were closer to 1 and thus it was more approximate to the classical music. Furthermore, the tempo of the filtered music with eyes closed was significantly slower than that with eyes open. With the original materials obtained from multi-channel EEGs, and a little creative filtering following the composition process of a potential artist, the resulted brainwave quartet opened a new window to look into the brain in an audible musical way. In fact, as the artistic beat and tonal filters were derived from the brainwaves, the filtered music maintained the essential properties of the brain activities in a more musical style. It might harmonically distinguish the different states of the brain activities, and therefore it provided a method to analyze EEGs from a relaxed audio perspective. PMID:23717527

  6. Scale-free brain quartet: artistic filtering of multi-channel brainwave music.

    Science.gov (United States)

    Wu, Dan; Li, Chaoyi; Yao, Dezhong

    2013-01-01

    To listen to the brain activities as a piece of music, we proposed the scale-free brainwave music (SFBM) technology, which translated scalp EEGs into music notes according to the power law of both EEG and music. In the present study, the methodology was extended for deriving a quartet from multi-channel EEGs with artistic beat and tonality filtering. EEG data from multiple electrodes were first translated into MIDI sequences by SFBM, respectively. Then, these sequences were processed by a beat filter which adjusted the duration of notes in terms of the characteristic frequency. And the sequences were further filtered from atonal to tonal according to a key defined by the analysis of the original music pieces. Resting EEGs with eyes closed and open of 40 subjects were utilized for music generation. The results revealed that the scale-free exponents of the music before and after filtering were different: the filtered music showed larger variety between the eyes-closed (EC) and eyes-open (EO) conditions, and the pitch scale exponents of the filtered music were closer to 1 and thus it was more approximate to the classical music. Furthermore, the tempo of the filtered music with eyes closed was significantly slower than that with eyes open. With the original materials obtained from multi-channel EEGs, and a little creative filtering following the composition process of a potential artist, the resulted brainwave quartet opened a new window to look into the brain in an audible musical way. In fact, as the artistic beat and tonal filters were derived from the brainwaves, the filtered music maintained the essential properties of the brain activities in a more musical style. It might harmonically distinguish the different states of the brain activities, and therefore it provided a method to analyze EEGs from a relaxed audio perspective.

  7. Measuring ensemble interdependence in a string quartet through analysis of multidimensional performance data

    Directory of Open Access Journals (Sweden)

    Panos ePapiotis

    2014-09-01

    Full Text Available In a musical ensemble such as a string quartet, the musicians interact and influence each other’s actions in several aspects of the performance simultaneously in order to achieve a common aesthetic goal. In this article, we present and evaluate a computational approach for measuring the degree to which these interactions exist in a given performance. We recorded a number of string quartet exercises under two experimental conditions (solo and ensemble, acquiring both audio and bowing motion data. Numerical features in the form of time series were extracted from the data as performance descriptors representative of four distinct dimensions of the performance: Intonation, Dynamics, Timbre and Tempo. Four different interdependence estimation methods (two linear and two nonlinear were applied to the extracted features in order to assess the overall level of interdependence between the four musicians. The obtained results suggest that it is possible to correctly discriminate between the two experimental conditions by quantifying interdependence between the musicians in each of the studied performance dimensions; the nonlinear methods appear to perform best for most of the numerical features tested. Moreover, by using the solo recordings as a reference to which the ensemble recordings are contrasted, it is feasible to compare the amount of interdependence that is established between the musicians in a given performance dimension across all exercises, and relate the results to the underlying goal of the exercise. We discuss our findings in the context of ensemble performance research, the current limitations of our approach, and the ways in which it can be expanded and consolidated.

  8. Význam European Quartet pre cestovný ruch krajín Vyšehradskej Štvorky

    OpenAIRE

    SVOBODOVÁ, Michaela

    2011-01-01

    This bachelor thesis deals with the importance of the project European Quartet-One Melody for the tourism in the Visegrad group contries. In the first chapter, there are explained definitions of terms appearing in the thesis (primarily marketing and managemet of destination). The second chapter describes the tourism and its caracteristics in individual countries. The last chapter is focused on the colaboration of national tourist offices, the project European Quartet-One Melody and evaluation...

  9. Classification of g-quadruplex DNA on the basis of the quadruplex twist angle and planarity of g-quartets.

    Science.gov (United States)

    Reshetnikov, R V; Kopylov, A M; Golovin, A V

    2010-10-01

    The present work is devoted to the analysis of the G-quadruplex DNA structure using the bioinformatics method. The interest towards quadruplex DNAs is determined by their involvement in the functioning of telomeres and onco-promoters as well as by the possibility to create on their basis aptamers and nanostructures. Here, we present an algorithm for a general analysis of the polymorphism of the G-quadruplex structure from the data bank PDB using original parameters. 74 structures were grouped according to the following parameters: the number of DNA strands, the number of G-quartets, and the location and orientation of the connecting loops. Two quantitative parameters were used to describe the quadruplex structure: the twist angle between two adjacent quartets (analogous to that for the complementary pair in the duplex DNA) and the quartet planarity (an original parameter). The distribution patterns of these values are specific for each group of quadruplex structures and are dependent upon the type of connecting loops used (diagonal, lateral or propeller). The tetramolecular loopless parallel quadruplex was used as a comparison template. The lateral loops introduce the strongest distortion into the structure of quadruplexes: the values of the twist angles are the lowest and are not typical for the other quadruplex groups. The loops of the diagonal type introduce much weaker deformation into quadruplexes; the structures with propeller loops are characterized by the optimum geometry of G-quartets. Hence, the correlation between the twist angle and the tension in the structure of quadruplex DNA is revealed.

  10. Music regulators in two string quartet ensembles: a comparison of communicative behaviours between low- and high-stress performance conditions

    Directory of Open Access Journals (Sweden)

    Michele Biasutti

    2016-08-01

    Full Text Available In ensemble performances, group members use particular bodily behaviours as a sort of language to supplement the lack of verbal communication. This research study focuses on music regulators, which are defined as signs to other group members for coordinating performance. The following two music regulators are considered: body gestures for articulating attacks (a set of movements externally directed that are used to signal entrances in performance and eye contacts. These regulators are recurring observable behaviors that play an important role in nonverbal communication among ensemble members. To understand how these regulators are used by chamber musicians, video recordings of members of two string quartet ensemble performances (Quartet Ensemble A performing Bartók and Quartet Ensemble B performing Haydn were analysed under two conditions: a low stress performance (LSP, undertaken in a rehearsal setting, and a high stress performance (HSP during a live concert. The results provide evidence for more emphasis in gestures for articulating attacks (i.e. the perceived strength of a performed attack-type body gestures during HSP than LSP. . Conversely, no significant differences were found for the frequency of eye contact between HSP and LSP. Moreover, there was variability in eye contacts during HSP and LSP, showing that these behaviours are less standardised and may change according to idiosyncratic performing conditions. Educational implications are discussed for improving interpersonal communication skills during ensemble performance.

  11. The movements made by performers in a skilled quartet: a distinctive pattern, and the function that it serves

    Directory of Open Access Journals (Sweden)

    Donald eGlowinski

    2013-11-01

    Full Text Available When people perform a task as part of a joint action, their behavior is not the same as it would be if they were performing the same task alone, since it has to be adapted to facilitate shared understanding (or sometimes to prevent it. Joint performance of music offers a test bed for ecologically valid investigations of the way non-verbal behavior facilitates joint action. Here we compare the expressive movement of violinists when playing in solo and ensemble conditions. The first violinists of two string quartets, professional and student, were asked to play the same musical fragments in a solo condition and with the quartet. Synchronized multimodal recordings were created from the performances, using a specially developed software platform. Different patterns of head movement were observed. By quantifying them using an appropriate measure of entropy, we showed that head movements are more predictable in the quartet scenario. Rater evaluations showed that the change does not, as might be assumed, entail markedly reduced expression. They showed some ability to discriminate between solo and ensemble performances, but did not distinguish them in terms of emotional content or expressiveness. The data raise provocative questions about joint action in realistically complex scenarios.

  12. Music Regulators in Two String Quartets: A Comparison of Communicative Behaviors between Low- and High-Stress Performance Conditions

    Science.gov (United States)

    Biasutti, Michele; Concina, Eleonora; Wasley, David; Williamon, Aaron

    2016-01-01

    In ensemble performances, group members use particular bodily behaviors as a sort of “language” to supplement the lack of verbal communication. This article focuses on music regulators, which are defined as signs to other group members for coordinating performance. The following two music regulators are considered: body gestures for articulating attacks (a set of movements externally directed that are used to signal entrances in performance) and eye contact. These regulators are recurring observable behaviors that play an important role in non-verbal communication among ensemble members. To understand how they are used by chamber musicians, video recordings of two string quartet performances (Quartet A performing Bartók and Quartet B performing Haydn) were analyzed under two conditions: a low stress performance (LSP), undertaken in a rehearsal setting, and a high stress performance (HSP) during a public recital. The results provide evidence for more emphasis in gestures for articulating attacks (i.e., the perceived strength of a performed attack-type body gesture) during HSP than LSP. Conversely, no significant differences were found for the frequency of eye contact between HSP and LSP. Moreover, there was variability in eye contact during HSP and LSP, showing that these behaviors are less standardized and may change according to idiosyncratic performance conditions. Educational implications are discussed for improving interpersonal communication skills during ensemble performance. PMID:27610089

  13. Music Regulators in Two String Quartets: A Comparison of Communicative Behaviors between Low- and High-Stress Performance Conditions.

    Science.gov (United States)

    Biasutti, Michele; Concina, Eleonora; Wasley, David; Williamon, Aaron

    2016-01-01

    In ensemble performances, group members use particular bodily behaviors as a sort of "language" to supplement the lack of verbal communication. This article focuses on music regulators, which are defined as signs to other group members for coordinating performance. The following two music regulators are considered: body gestures for articulating attacks (a set of movements externally directed that are used to signal entrances in performance) and eye contact. These regulators are recurring observable behaviors that play an important role in non-verbal communication among ensemble members. To understand how they are used by chamber musicians, video recordings of two string quartet performances (Quartet A performing Bartók and Quartet B performing Haydn) were analyzed under two conditions: a low stress performance (LSP), undertaken in a rehearsal setting, and a high stress performance (HSP) during a public recital. The results provide evidence for more emphasis in gestures for articulating attacks (i.e., the perceived strength of a performed attack-type body gesture) during HSP than LSP. Conversely, no significant differences were found for the frequency of eye contact between HSP and LSP. Moreover, there was variability in eye contact during HSP and LSP, showing that these behaviors are less standardized and may change according to idiosyncratic performance conditions. Educational implications are discussed for improving interpersonal communication skills during ensemble performance.

  14. The movements made by performers in a skilled quartet: a distinctive pattern, and the function that it serves

    Science.gov (United States)

    Glowinski, Donald; Mancini, Maurizio; Cowie, Roddy; Camurri, Antonio; Chiorri, Carlo; Doherty, Cian

    2013-01-01

    When people perform a task as part of a joint action, their behavior is not the same as it would be if they were performing the same task alone, since it has to be adapted to facilitate shared understanding (or sometimes to prevent it). Joint performance of music offers a test bed for ecologically valid investigations of the way non-verbal behavior facilitates joint action. Here we compare the expressive movement of violinists when playing in solo and ensemble conditions. The first violinists of two string quartets (SQs), professional and student, were asked to play the same musical fragments in a solo condition and with the quartet. Synchronized multimodal recordings were created from the performances, using a specially developed software platform. Different patterns of head movement were observed. By quantifying them using an appropriate measure of entropy, we showed that head movements are more predictable in the quartet scenario. Rater evaluations showed that the change does not, as might be assumed, entail markedly reduced expression. They showed some ability to discriminate between solo and ensemble performances, but did not distinguish them in terms of emotional content or expressiveness. The data raise provocative questions about joint action in realistically complex scenarios. PMID:24312065

  15. Rydberg series for quartet states of Li-like sulfur ion

    Science.gov (United States)

    Sun, Yan; Sang, CuiCui; Hu, Feng; Qian, XinYu; Liu, DongDong; Mei, MaoFei; Gou, BingCong

    2017-01-01

    The energy levels and transition parameters of Li-like quartet states 1s2snl and 1s2pnl‧ (l=s, p, d; l‧=s, p, d, f; n=2-7) pertaining to 4Po and 4Le (L=S, P, D) Rydberg series in S13+ ion are calculated using a multi-configuration Rayleigh-Ritz variation method. Relativistic effects and mass polarization contributions are taken into account by using the first-order perturbation theory. The quantum electrodynamics (QED) effects and higher-order relativistic corrections are considered to obtain accurate energy levels by the screened hydrogenic formula. The transition oscillator strengths, transition rates, and wavelengths of electric-dipole transitions for 1s2sns4Se-1s2lnl‧ 4Po and 1s2snp+1s2pns+1s2pnd4Po-1s2lnl‧ 4Le (L=S, P, D) in S13+ ion are systematically calculated and compared with available reference data. Our calculated results will provide valuable data for related experiments in the future.

  16. Comparison of sequencing based CNV discovery methods using monozygotic twin quartets.

    Directory of Open Access Journals (Sweden)

    Marc-André Legault

    Full Text Available The advent of high throughput sequencing methods breeds an important amount of technical challenges. Among those is the one raised by the discovery of copy-number variations (CNVs using whole-genome sequencing data. CNVs are genomic structural variations defined as a variation in the number of copies of a large genomic fragment, usually more than one kilobase. Here, we aim to compare different CNV calling methods in order to assess their ability to consistently identify CNVs by comparison of the calls in 9 quartets of identical twin pairs. The use of monozygotic twins provides a means of estimating the error rate of each algorithm by observing CNVs that are inconsistently called when considering the rules of Mendelian inheritance and the assumption of an identical genome between twins. The similarity between the calls from the different tools and the advantage of combining call sets were also considered.ERDS and CNVnator obtained the best performance when considering the inherited CNV rate with a mean of 0.74 and 0.70, respectively. Venn diagrams were generated to show the agreement between the different algorithms, before and after filtering out familial inconsistencies. This filtering revealed a high number of false positives for CNVer and Breakdancer. A low overall agreement between the methods suggested a high complementarity of the different tools when calling CNVs. The breakpoint sensitivity analysis indicated that CNVnator and ERDS achieved better resolution of CNV borders than the other tools. The highest inherited CNV rate was achieved through the intersection of these two tools (81%.This study showed that ERDS and CNVnator provide good performance on whole genome sequencing data with respect to CNV consistency across families, CNV breakpoint resolution and CNV call specificity. The intersection of the calls from the two tools would be valuable for CNV genotyping pipelines.

  17. Blend in Singing Ensemble Performance: Vibrato Production in a Vocal Quartet.

    Science.gov (United States)

    Daffern, Helena

    2017-05-01

    "Blend" is a defining characteristic of good vocal ensemble performance. To achieve this, directors often consider vibrato as a feature to be controlled and consequently restrict its use. Analysis of individual voices in ensemble situations presents several challenges, including the isolation of voices for analysis from recordings. This study considers vibrato production as a feature that contributes to blend through an ecological study of a vocal quartet. A vocal ensemble was recorded using head-worn microphones and electrolaryngograph electrodes to enable fundamental frequency analysis of the individual voices. The same four-part material was recorded over several weeks of rehearsal to allow analysis of conscious and subconscious changes to vibrato production over time. Alongside the recording of their rehearsal discussions, singers were also asked for opinions on vibrato production in connection with blend. The results indicate that vibrato is adjusted to some extent by individual singers to improve blend, with some instances of synchrony between voice parts. Some conscious alterations to vibrato were made to improve blend; however, these are not always evident in the data, suggesting that singers' own perceptions of their performance may be influenced by other factors. These findings indicate a need for further studies of vibrato as a feature of blend, particularly in terms of the synergies between expectation and actual production, and potential synchronicity between singers; increased understanding of vibrato in an ensemble setting will lead to more efficient rehearsal techniques and vocal training, and could prevent vocal misuse leading to pathology in the future. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  18. Pitch and Harmony in Gyorgy Ligeti's "Hamburg Concerto" and "Syzygy" for String Quartet

    Science.gov (United States)

    Corey, Charles

    analysis clearly shows that very simple musical intervals turn out to be cornerstones of this piece, traceable throughout the entire Hamburg Concerto. The composition, Syzygy for string quartet, is written in just intonation. Through four movements, the relationships evoked by the titles (always groups of homonyms) are examined and illuminated.

  19. Using the radium quartet to quantify submarine groundwater discharge and porewater exchange

    Science.gov (United States)

    Rodellas, Valentí; Garcia-Orellana, Jordi; Trezzi, Giada; Masqué, Pere; Stieglitz, Thomas C.; Bokuniewicz, Henry; Cochran, J. Kirk; Berdalet, Elisa

    2017-01-01

    The specific ingrowth rates of different radium isotopes make them valuable tracers to distinguish processes occurring at different temporal scales. Here we demonstrate the use of the radium quartet (223Ra, 224Ra, 226Ra and 228Ra) to differentiate flows of submarine groundwater discharge and porewater exchange to a coastal embayment (Alfacs Bay, NW Mediterranean Sea), based on the assumption that these processes occur on different time scales. In order to evaluate the seasonal dynamics of groundwater and porewater inputs to the bay, we conducted three seasonal samplings at Alfacs Bay, during which samples for Ra isotopes were collected from bay waters, groundwater springs, porewaters and irrigation channels. Activities of short-lived Ra isotopes in the bay showed a strong seasonality, (e.g. average 224Ra activities in summer (∼32 dpm 100 L-1) up to 4 times higher than in winter (∼8 dpm 100 L-1)). In contrast, the activities of the long-lived Ra isotopes were fairly constant throughout the year (e.g. activities of 226Ra were ∼16 and ∼14 dpm 100 L-1 in summer and winter, respectively). The relatively short exposure to sediments of recirculation fluxes resulted in porewaters significantly enriched in short-lived Ra isotopes relative to the long-lived ones (e.g. 224Ra = 1100-1300 dpm 100 L-1; 226Ra = 17-99 dpm 100 L-1), whereas coastal groundwaters were enriched in all the Ra isotopes (e.g. 224Ra = 120-150 dpm 100 L-1; 226Ra = 200-400 dpm 100 L-1). The distinct signatures of different sources allowed us to construct seasonal Ra mass balances to estimate both groundwater discharge, which ranges from (40 ± 60)·103 m3·d-1 in summer to (310 ± 200)·103 m3·d-1 in winter, and porewater exchange fluxes, ranging from (1200 ± 120)·103 m3·d-1 in summer to (270 ± 40)·103 m3·d-1 in winter. Whereas the seasonal variability of groundwater inputs is likely governed by the terrestrial hydraulic gradient, a qualitative evaluation of the drivers of porewater exchange

  20. Tuning the position of unpaired electrons and doublet-quartet gap of the 1,3,5-trimethylenebenzene triradical by nitrogen, phosphorus and arsenic substitution

    Science.gov (United States)

    Höltzl, Tibor; Veszprémi, Tamás; Nguyen, Minh Tho

    2010-10-01

    Substitution of C-H groups in 1,3,5-trimethylenebenzene (1,3,5-TMB) triradical by one, two or three N, P and As atoms is studied using CASSCF/CASPT2 computations with a ANO-RCC triple-ζ basis set. The computations showed that consistently with the previous results, the unpaired electrons in 1,3,5-TMB are highly delocalized, but our computations show that they become localized on the P and As atoms, with a more pronounced localization effect of As. All studied compounds have a quartet ground state, but the results showed in this Letter indicate that the quartet-doublet energy gap is reduced upon substitution. Localization of the unpaired electrons on the ring reduces the average distances between them, which induces a destabilization of the quartet states compared to the doublet. Therefore the position of the unpaired electrons and the doublet-quartet gap can be tuned by chemical methods, which opens the way to fine-tune the properties of the building blocks of organic magnets.

  1. The Ha Velocity Fields and Galaxy Interaction in the Quartet of Galaxies NGC 7769, 7770, 7771 and 7771A

    CERN Document Server

    Yeghiazaryan, A A; Hakobyan, A A

    2015-01-01

    The quartet of galaxies NGC 7769, 7770, 7771 and 7771A is a system of interacting galaxies. Close interaction between galaxies caused characteristic morphological features: tidal arms and bars, as well as an induced star formation. In this study, we performed the Fabry-Perot scanning interferometry of the system in Ha line and studied the velocity fields of the galaxies. We found that the rotation curve of NGC 7769 is weakly distorted. The rotation curve of NGC 7771 is strongly distorted with the tidal arms caused by direct flyby of NGC 7769 and flyby of a smaller neighbor NGC 7770. The rotation curve of NGC 7770 is significantly skewed because of the interaction with much massive NGC 7771. The rotation curves and morphological disturbances suggest that the NGC 7769 and NGC 7771 have passed the first pericenter stage, however, probably the second encounter has not happened yet. Profiles of surface brightness of NGC 7769 have a characteristic break, and profiles of color indices have a minimum at a radius of i...

  2. G-quartet oligonucleotide mediated delivery of proteins into photoreceptors and retinal pigment epithelium via intravitreal injection.

    Science.gov (United States)

    Leaderer, Derek; Cashman, Siobhan M; Kumar-Singh, Rajendra

    2016-04-01

    There is currently no available method to efficiently deliver proteins across the plasma membrane of photoreceptor or retinal pigment epithelium (RPE) cells in vivo. Thus, current clinical application of recombinant proteins in ophthalmology is limited to the use of proteins that perform their biological function extracellularly. The ability to traverse biological membranes would enable the mobilization of a significantly larger number of proteins with previously well characterized properties. Nucleolin is abundantly present on the surface of rapidly dividing cells including cancer cells. Surprisingly, nucleolin is also present on the surface of photoreceptor cell bodies. Here we investigated whether nucleolin can be utilized as a gateway for the delivery of proteins into retinal cells following intravitreal injection. AS1411 is a G-quartet aptamer capable of targeting nucleolin. Subsequent to intravitreal injection, fluorescently labeled AS1411 localized to various retinal cell types including the photoreceptors and RPE. AS1411 linked to streptavidin (a ∼50 kDa protein) via a biotin bridge enabled the uptake of Streptavidin into photoreceptors and RPE. AS1411-Streptavidin conjugate applied topically to the cornea allowed for uptake of the conjugate into the nucleus and cytoplasm of corneal endothelial cells. Clinical relevance of AS1411 as a delivery vehicle was strongly indicated by demonstration of the presence of cell surface nucleolin on the photoreceptors, inner neurons and ganglion cells of human retina. These data support exploration of AS1411 as a means of delivering therapeutic proteins to diseased retina.

  3. Critical Assessment of Time-Dependent Density Functional Theory for Excited States of Open-Shell Systems: II. Doublet-Quartet Transitions.

    Science.gov (United States)

    Li, Zhendong; Liu, Wenjian

    2016-06-14

    Compared with closed-shell systems, open-shell systems place three additional challenges to time-dependent density functional theory (TD-DFT) for electronically excited states: (a) the spin-contamination problem is a serious issue; (b) the exchange-correlation (XC) kernel may be numerically instable; and (c) the single-determinant description of open-shell ground states readily becomes energetically instable. Confined to flip-up single excitations, the spin-contamination problem can largely be avoided by using the spin-flip TD-DFT (SF-TD-DFT) formalism, provided that a noncollinear XC kernel is employed. As for the numerical instabilities associated with such a kernel, only an ad hoc scheme has been proposed so far, viz., the ALDA0 kernel, which amounts to setting the divergent components (arising from density gradients and kinetic energy density) simply to zero. The ground-state instability problem can effectively be avoided by introducing the Tamm-Dancoff approximation (TDA) to TD-DFT. Therefore, on a general basis, the SF-TDA/ALDA0 Ansatz is so far the only promising means within the TD-DFT framework for flip-up single excitations of open-shell systems. To assess systematically the performance of SF-TDA/ALDA0, in total 61 low-lying quartet excited states of the benchmark set of 11 small radicals [J. Chem. Theory Comput. 2016, 12, 238] are investigated with various XC functionals. Taking the MRCISD+Q (multireference configuration interaction with singles and doubles plus the Davidson correction) results as benchmark, it is found that the mean absolute errors of SF-TDA/ALDA0 with the SAOP (statistical averaging of model orbital potentials), global hybrid, and range-separated hybrid functionals are in the range of 0.2-0.4 eV. This is in line not only with the typical accuracy of TD-DFT for singlet and triplet excited states of closed-shell systems but also with the gross accuracy of spin-adapted TD-DFT for spin-conserving excited states of open-shell systems.

  4. The even-even nucleus {sup 196}Hg and its relation to the ''magical quartet'' around {sup 194}Pt

    Energy Technology Data Exchange (ETDEWEB)

    Bernards, Christian; Albers, Michael; Fransen, Christoph; Heinze, Stefan; Jolie, Jan; Radeck, Desiree; Thomas, Tim [Institute for Nuclear Physics, University of Cologne (Germany)

    2009-07-01

    The investigation of {sup 196}Hg - especially the determination of level spins and multipole mixing ratios of {gamma} transitions between low-energy states - is of great interest for testing the existence of a relation between the nucleus {sup 196}Hg and the so-called magical quartet around {sup 194}Pt. Within the U{sub {nu}}(6/12) x U{sub {pi}}(6/4) extended supersymmetry, this quartet is supposed to be the supermultiplet being described the best. Similar to the quartet members {sup 194,195}Pt and {sup 195,196}Au, the nucleus {sup 196}Hg can be described theoretically by seven IBA-2 particles to the shell closure, in particular by two j = 3/2 proton fermions and five sd neutron bosons as a two-fermions - five-bosons supermultiplet member. In order to obtain experimental data on {sup 196}Hg a {gamma}{gamma} angular correlation experiment was performed at the Tandem accelerator of the Institute for Nuclear Physics in Cologne. Using a {sup 4}He beam with an energy of 28 MeV impinging a {sup 194}Pt target the reaction {sup 194}Pt({alpha}, 2n){sup 196}Hg was induced. To analyze the {gamma} decays of yrast and non-yrast {sup 196}Hg states 13 high purity germanium detectors were mounted in the Horus cube {gamma}-ray spectrometer, which allows the determination of level spins and multipole mixing ratios by the analysis of {gamma}{gamma} angular correlations. We discuss first results of the experiment.

  5. Cantico Delle Creature: A microtonal original composition for soprano and string quartet to a text by St. Francis of Assisi, including analytical commentary

    Science.gov (United States)

    Sabol, Jason A.

    Cantico delle Creature is an original piece of music for soprano and string quartet composed in 72 tone per octave equal temperament, dividing each semitone into six equal parts called twelfth-tones. This system of tuning makes it possible to combine just intonation and spectral principles based on the harmonic series with real imitation, modulation, and polyphony. Supplemental text discusses several aspects of microtonal structure and pedagogy, including the representation of the first 64 partials of the harmonic series in 72 tone equal temperament, performance of natural string harmonics, the relationship between interval size and vibration ratio, pitch to frequency conversion, and analysis of several passages in the musical score.

  6. Connectivity patterns and rotamer states of nucleobases determine acid-base properties of metalated purine quartets.

    Science.gov (United States)

    Lüth, Marc Sven; Freisinger, Eva; Kampf, Gunnar; Garijo Anorbe, Marta; Griesser, Rolf; Operschall, Bert P; Sigel, Helmut; Lippert, Bernhard

    2015-07-01

    Potentiometric pH titrations and pD dependent (1)H NMR spectroscopy have been applied to study the acidification of the exocyclic amino group of adenine (A) model nucleobases (N9 position blocked by alkyl groups) when carrying trans-a2Pt(II) (with a=NH3 or CH3NH2) entities both at N1 and N7 positions. As demonstrated, in trinuclear complexes containing central A-Pt-A units, it depends on the connectivity pattern of the adenine bases (N7/N7 or N1/N1) and their rotamer states (head-head or head-tail), how large the acidifying effect is. Specifically, a series of trinuclear complexes with (A-N7)-Pt-(N7-A) and (A-N1)-Pt-(N1-A) cross-linking patterns and terminal 9-alkylguanine ligands (9MeGH, 9EtGH) have been analyzed in this respect, and it is shown that, for example, the 9MeA ligands in trans-,trans-,trans-[Pt(NH3)2(N7-9MeA-N1)2{Pt(NH3)2(9EtGH-N7)}2](ClO4)6·6H2O (4a) and trans-,trans-,trans-[Pt(NH3)2(N7-9EtA-N1)2{Pt(CH3NH2)2(9-MeGH-N7)}2](ClO4)6·3H2O (4b) are more acidic, by ca. 1.3 units (first pKa), than the linkage isomer trans-,trans-,trans-[Pt(CH3NH2)2(N1-9MeA-N7)2{Pt(NH3)2(9MeGH-N7)}2](NO3)6·6.25H2O (1b). Overall, acidifications in these types of complexes amount to 7-9 units, bringing the pKa values of such adenine ligands in the best case close to the physiological pH range. Comparison with pKa values of related trinuclear Pt(II) complexes having different co-ligands at the Pt ions, confirms this picture and supports our earlier proposal that the close proximity of the exocyclic amino groups in a head-head arrangement of (A-N7)-Pt-(N7-A), and the stabilization of the resulting N6H(-)⋯H2N6 unit, is key to this difference.

  7. FATAL QUARTET OR QUINTET?

    Directory of Open Access Journals (Sweden)

    Y. V. Sviryaev

    2011-01-01

    Full Text Available Correction of potential risk factors is essential for effective therapy for cardiovascular diseases. This clinical case demonstrates negative impact of non-corrected risk factors — obstructive sleep apnea — in occurrence and further progression of cardiovascular disease.

  8. A Harmonious Quartet

    Institute of Scientific and Technical Information of China (English)

    YAN WEI

    2010-01-01

    @@ When Goldman Sachs first coined the BRIC concept a decade ago, the international investment and securities firm by no means expected that Brazil, Russia, India and China would later unite into a formal alliance. Indeed, if anything, the four fast-growing Economics have since proven that BRIC represents far more than just an eye-catching acronym.

  9. Low-Temperature Softening Due to Vacancy Orbital with Γ8 Quartet Ground State in Boron-Doped Floating Zone Silicon

    Science.gov (United States)

    Baba, Shotaro; Akatsu, Mitsuhiro; Mitsumoto, Keisuke; Komatsu, Satoru; Horie, Kunihiko; Nemoto, Yuichi; Yamada-Kaneta, Hiroshi; Goto, Terutaka

    2013-08-01

    We have carried out low-temperature ultrasonic measurements using shear-mode ultrasound to clarify the quantum state of a vacancy orbital in boron-doped silicon grown by the floating zone (FZ) method. The elastic constants (C11-C12)/2 and C44 of the transverse mode exhibit considerable softening below 2 and 5 K down to the base temperature of 30 mK, respectively. The elastic constant C44 measured by the three ultrasonic modes (kx,uy), (kz,ux), and (kx,uz) shows the different magnetic field dependences among the configurations under applied magnetic fields along the z-axis. The elastic softening and the magnetic field dependence of the elastic constants are accounted for by the quadrupole susceptibility based on the energy level scheme of the vacancy orbital with a Γ8 quartet ground state and Γ7 doublet excited state located at an energy of 1 K. The difference in C44 between the two ultrasonic modes (kz,ux) and (kx,uz) at fields along the z-axis indicates that the Γ8 quartet ground state is slightly split by local strain in the silicon sample. The quantum state of the vacancy orbital is expected to be sensitive to strain because of the extremely large quadrupole-strain coupling energy of gΓ≈ 105 K due to the extensively spreading orbital radius of r≈ 1 nm. The differences in variation of the low-temperature softening and magnetic field dependence among eight samples cut out from different locations of the present boron-doped FZ silicon ingot evidence the inhomogeneous distribution of the vacancy concentration.

  10. $\\rm{H}\\alpha$ Velocity Fields and Galaxy Interaction in the Quartet of Galaxies NGC 7769, 7770, 7771 and 7771A

    Indian Academy of Sciences (India)

    A. A. Yeghiazaryan; T. A. Nazaryan; A. A. Hakobyan

    2016-03-01

    The quartet of galaxies NGC 7769, 7770, 7771 and 7771A is a system of interacting galaxies. Close interaction between galaxies caused characteristic morphological features: tidal arms and bars, as well as an induced star formation. In this study, we performed the Fabry–Perot scanning interferometry of the system in $\\rm{H}\\alpha$ line and studied the velocity fields of the galaxies. We found that the rotation curve of NGC 7769 is weakly distorted. The rotation curve of NGC 7771 is strongly distorted with the tidal arms caused by direct flyby of NGC 7769 and flyby of a smaller neighbor NGC 7770. The rotation curve of NGC 7770 is significantly skewed because of the interaction with the much massive NGC 7771. The rotation curves and morphological disturbances suggest that the NGC 7769 and NGC 7771 have passed the first pericenter stage, however, probably the second encounter has not happened yet. Profiles of surface brightness of NGC 7769 have a characteristic break, and profiles of color indices have a minimum at a radius of intensive star formation induced by the interaction with NGC 7771.

  11. [Medicine, music, friendship and prejudices: Billroth I and Billroth II, the string quartets Opus 51, N° 1 and N° 2 by Johannes Brahms].

    Science.gov (United States)

    Cabello, Felipe C

    2012-06-01

    The great German surgeon Theodor Billroth and the imaginative and creative composer Johannes Brahms had a very close friendship centered on musical activities, that lasted for more than thirty years while they lived and worked in Zurich and Vienna, during the second half of the Nineteenth Century. Billroth, besides his all-consuming medical activities, had time to be a musical enthusiast who directed orchestras, played the violin in chamber music groups, and wrote musical criticism for newspapers. The common affection between these two creative giants is documented by their abundant and effusive correspondence, by the constant requests by Brahms of Billroth's opinions regarding his compositions, and by the positive and stimulating answers that Billroth gave to these requests. Billroth opened his house for musical evenings to play Brahms chamber compositions for the first time, and Brahms dedicated his two Opus 51 string quartets Nos. 1 and 2, known in the musical milieu as Billroth I and II, to his physician friend. Unfortunately, the close bonds between these two geniuses weakened towards the end of their lives as a result of Billroth's becoming intolerant to the lack of social refinements and gruff behavior of the composer. This baffling intolerance of Billroth to his friend Brahms can be better understood after reading Billroth's writings in his book The Medical Sciences in the German Universities. A Study in the History of Civilization. There Billroth expresses strong prejudices against potential medical students of humble social origins, such as those of Brahms, coupled to a primitive anti-Semitism.

  12. An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates.

    Science.gov (United States)

    O'Day, Elizabeth; Le, Minh T N; Imai, Shunsuke; Tan, Shen Mynn; Kirchner, Rory; Arthanari, Haribabu; Hofmann, Oliver; Wagner, Gerhard; Lieberman, Judy

    2015-07-17

    Lin28 is an evolutionarily conserved RNA-binding protein that inhibits processing of pre-let-7 microRNAs (miRNAs) and regulates translation of mRNAs that control developmental timing, pluripotency, metabolism, and tumorigenesis. The RNA features that mediate Lin28 binding to the terminal loops of let-7 pre-miRNAs and to Lin28-responsive elements (LREs) in mRNAs are not well defined. Here we show that Lin28 target datasets are enriched for RNA sequences predicted to contain stable planar structures of 4 guanines known as G-quartets (G4s). The imino NMR spectra of pre-let-7 loops and LREs contain resonances characteristic of G4 hydrogen bonds. These sequences bind to a G4-binding fluorescent dye, N-methyl-mesoporphyrin IX (NMM). Mutations and truncations in the RNA sequence that prevent G4 formation also prevent Lin28 binding. The addition of Lin28 to a pre-let-7 loop or an LRE reduces G4 resonance intensity and NMM binding, suggesting that Lin28 may function to remodel G4s. Further, we show that NMM inhibits Lin28 binding. Incubation of a human embryonal carcinoma cell line with NMM reduces its stem cell traits. In particular it increases mature let-7 levels, decreases OCT4, HMGA1, CCNB1, CDK4, and Lin28A protein, decreases sphere formation, and inhibits colony formation. Our results suggest a previously unknown structural feature of Lin28 targets and a new strategy for manipulating Lin28 function. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  13. An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates*

    Science.gov (United States)

    O'Day, Elizabeth; Le, Minh T. N.; Imai, Shunsuke; Tan, Shen Mynn; Kirchner, Rory; Arthanari, Haribabu; Hofmann, Oliver; Wagner, Gerhard; Lieberman, Judy

    2015-01-01

    Lin28 is an evolutionarily conserved RNA-binding protein that inhibits processing of pre-let-7 microRNAs (miRNAs) and regulates translation of mRNAs that control developmental timing, pluripotency, metabolism, and tumorigenesis. The RNA features that mediate Lin28 binding to the terminal loops of let-7 pre-miRNAs and to Lin28-responsive elements (LREs) in mRNAs are not well defined. Here we show that Lin28 target datasets are enriched for RNA sequences predicted to contain stable planar structures of 4 guanines known as G-quartets (G4s). The imino NMR spectra of pre-let-7 loops and LREs contain resonances characteristic of G4 hydrogen bonds. These sequences bind to a G4-binding fluorescent dye, N-methyl-mesoporphyrin IX (NMM). Mutations and truncations in the RNA sequence that prevent G4 formation also prevent Lin28 binding. The addition of Lin28 to a pre-let-7 loop or an LRE reduces G4 resonance intensity and NMM binding, suggesting that Lin28 may function to remodel G4s. Further, we show that NMM inhibits Lin28 binding. Incubation of a human embryonal carcinoma cell line with NMM reduces its stem cell traits. In particular it increases mature let-7 levels, decreases OCT4, HMGA1, CCNB1, CDK4, and Lin28A protein, decreases sphere formation, and inhibits colony formation. Our results suggest a previously unknown structural feature of Lin28 targets and a new strategy for manipulating Lin28 function. PMID:26045559

  14. Heraclitean logos and flux in T.S. Eliot’s Four Quartets: 'cosmic consciousness' and 'the still point of the turning world'

    Directory of Open Access Journals (Sweden)

    A. Wessels

    2001-08-01

    Full Text Available T.S. Eliot prefaces “Burnt Norton”, the first of his Four Quartets, with two quotations from the Greek philosopher, Heraclitus. By means of these epigrams, Eliot points us to the Heraclitean opposition and paradoxical interdependence between logos and flux as a paradigm in the poem, a paradigm that he uses for an investigation and articulation of a number of philosophical contemplations. In this paper, I discuss Eliot’s different configurations of the logos/flux paradigm in the poem, firstly to illuminate the relationship between temporality and eternity, secondly, to elaborate the relationship between God and humanity, and thirdly to express the relationship between structured art and chaotic experience. In each instance it is not only the opposition between the two elements that is important, but also the point of contact, the intersection. There is some evidence that Eliot’s depiction of this intersection as, for example, the “moment in and out of time”, is based on personal experience of a transcendent, mystical nature. His expression of this experience is also investigated by comparing it to similar experiences described by others, notably by a Canadian psychiatrist, Richard Maurice Bucke. A comparison of Bucke’s description in his evolutionist text of 1901 and Eliot’s poetic rendering reveals not only surprising similarities but also essential differences which highlights Eliot’s purely Christian interpretation in the face of Bucke’s more universalist approach. For T.S. Eliot, eternity or timelessness can only be accessed through the temporal experience of human consciousness, in fleeting moments of exaltation in daily life, in the charged, timeless configurations of art as an imitation of divine creation, and finally in Christ, who embodies the love of God and is for Eliot the ultimate transection of the temporal and eternal, the flux and the logos.

  15. On Zhu Jian-er five quartets"He"%中西合璧立足超越--试析朱践耳五重奏《和》

    Institute of Scientific and Technical Information of China (English)

    曹晔

    2013-01-01

      《和》是1992年朱践耳先生基于现代音乐观念创作的一部五重奏作品,作曲家在《和》中将古、今、中、西的思维、技法、观念相融合,既发扬传统,又超越传统;既取法现代,又超越现代。本文从文化内涵、音乐语言特色和音乐技术应用、音乐结构、风格特征等几个方面对这部作品进行分析,力求对这部具有个性和现代意识的中国作品有一个新的审美认识。%"He"is the concept of modern music creation of works based on the fusion of five quartets by Mr. Zhu Jian-er in 1992, in"He", composer combines the ancient and modern, western, thinking, skills, ideas, not only carry forward the tradition, but also beyond the traditional method;not only modern, and beyond the modern.This article carries on the analysis to this work from several cultural connotation, music language and music technology, music structure, style characteristics, in order to have a new aesthetic understanding of the personality and the consciousness of modern Chinese works.

  16. On Zhu Xi's Harmony Quartet and its Impact on Contemporary Society%朱子和谐四重奏与当代社会

    Institute of Scientific and Technical Information of China (English)

    朱人求

    2011-01-01

    朱子是宋代新儒学的集大成者,是中华文化承先启后、继往开来的文化巨人。朱子和谐观包含四重含义:心和、人和、协和、中和,它们分别指向身心和谐、人际和谐、世界和谐和天人和谐,具有多维性和普遍性,是一个逐步放大的同心圆,一个逐步上升的理想境界。朱子的和谐四重奏,由低级到高级,由自我到他人,由人际到国别,由人类到宇宙,奏响了一曲美妙的乐章,对当代和谐社会的建构意义深远。%Zhu Xi is the greatest master of Neo-Confucianism in the Song Dynasty and a cultural giant in Chinese culture.Zhu Xi's theory of harmony contains four implications: harmony of mind,human,Concorde and medium,which respectively refer to harmony between body and mind,between persons,between countries and between nature and human.With multidimensionality and universality,Zhu Xi's harmony quartet is a step-by-step enlargement of concentric circles,a gradually rising ideal realm,from low to high,from self to others,from interpersonal to national,from human to universe,like a beautiful piece of music,which will have a far-reaching significance for the present construction of a harmonious society.

  17. Measurement of the dmud quartet-to-doublet molecular formation rate ratio (lambdaq : lambdad) and the mu d hyperfine rate (lambdaqd) using the fusion neutrons from mu- stops in D2 gas

    Science.gov (United States)

    Raha, Nandita

    The MuSun experiment will determine the microd capture rate (micro - + d → n + n + nue) from the doublet hyperfine state Lambdad, of the muonic deuterium atom in the 1S ground state to a precision of 1.5%. Modern effective field theories (EFT) predict that an accurate measurement of Lambdad would determine the two-nucleon weak axial current. This will help in understanding all weak nuclear interactions such as the stellar thermonuclear proton-proton fusion reactions, the neutrino reaction nu + d (which explores the solar neutrino oscillation problem). It will also help us understand weak nuclear interactions involving more than two nucleons---double beta decay---as they do involve a two-nucleon weak axial current term. The experiment took place in the piE3 beam-line of Paul Scherrer Institute (PSI) using a muon beam generated from 2.2 mA proton beam---which is the highest intensity beam in the world. The muons first passed through entrance scintillator and multiwire proportional chamber for determining thier entrance timing and position respectively. Then they were stopped in a cryogenic time projection chamber (cryo-TPC) filled with D2 gas. This was surrounded by plastic scintillators and multiwire proportional chambers for detecting the decay electrons and an array of eight liquid scintillators for detecting neutrons. Muons in deuterium get captured to form microd atoms in the quartet and doublet spin states. These atoms undergo nuclear capture from these hyperfine states respectively. There is a hyperfine transition rate from quartet-to-doublet state---lambdaqd along with dmicrod molecular formation which further undergoes a fusion reaction with the muon acting as a catalyst (MCF). The goal of this dissertation is to measure the dmicro d quartet-to-doublet rate ratio (lambdaq : lambdad) and microd hyperfine rate (lambda qd) using the fusion neutrons from micro. stops in D2 gas. The dmicrod molecules undergo MCF reactions from the doublet and the quartet state

  18. Spin-component-scaling second-order Møller-Plesset theory and its variants for economical correlation energies: unified theoretical interpretation and use for quartet N3.

    Science.gov (United States)

    Varandas, A J C

    2010-08-14

    The spin-component-scaling second-order Møller-Plesset theory proposed by Grimme, the scaled opposite-spin variant of Head-Gordon and co-workers, and other variants of the theory to treat the electron correlation energy are examined. A refinement of scaled opposite-spin theory for strong chemical interactions is suggested where the scaled correlation contribution is chosen such as to mimic closely the one obtained by more sophisticated methods of the coupled cluster type. With the scaling factor chosen to vary in a simple statistical manner with the number of opposite-spin electron pairs of the system, the parameters have been calibrated from standard coupled cluster type calculations for a chosen ab initio test data set. The new approach, termed as variable-scaling opposite spin, aims to be applicable at any regions of the molecule configuration space where second-order Møller-Plesset perturbation theory converges. It thus benefits of all advantages inherent to the original theory, which makes it an attractive approach on a computational cost basis. Because the method in one of its formats fails size-extensivity, the consequences and remedies of this are analyzed. Illustrations are presented for many molecules utilizing Dunning-type basis sets, in particular, for a detailed analysis of N(3) in its lowest quartet state, which does not belong to the test set. Extrapolations of the calculated raw energies to the complete one-electron basis set limit are also reported, giving the most reliable estimates available thus far of the energetics for the N((4)S)+N(2) exchange reaction. All spin-component-scaling schemes are known to show difficulties in dealing with weak interactions of the van der Waals type, which has justified the design of specific variants of the theory according to the property and regime of interactions. Several variants of the theory are then examined using a second test set of molecules, and shown to be linked via a coordinate that evolves

  19. Disentangling complex emotions with structured neurophysiological models. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Kaernbach, Christian

    2015-06-01

    Life is complex. Emotions help us to deal with life. So it should not come as a surprise that emotions are also complex. Emotion theories should help us to see through this complex world of emotions. In order to do so, they have to simplify things. However, they should not oversimplify.

  20. ABC model and floral evolution

    Institute of Scientific and Technical Information of China (English)

    LI Guisheng; MENG Zheng; KONG Hongzhi; CHEN Zhiduan; LU Anming

    2003-01-01

    The paper introduces the classical ABC model of floral development and thereafter ABCD, ABCDE and quartet models, and presents achievements in the studies on floral evolution such as the improved understanding on the relationship of reproductive organs between gnetophytes and angiosperms, new results in perianth evolution and identified homology of floral organs between dicots and monocots. The evo-devo studies on plant taxa at different evolutionary levels are useful to better understanding the homology of floral organs, and to clarifying the mysteries of the origin and subsequent diversification of flowers.

  1. Levels of analysis in neuroscientific studies of emotion: Comment on "The quartet theory of human emotions: an integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Kuiken, Don; Douglas, Shawn

    2015-06-01

    In the conduct of neuroscience research, methodological choices and theoretical claims often reveal underlying metamethodological and ontological commitments. Koelsch et al. [1] accentuate such commitments in their description of four "neuroanatomically distinct systems," each the substrate of "a specific class of affects" (p. 1). Explication of those classes of affect require theoretical integration across methodologically diverse disciplines, including "psychology, neurobiology, sociology, anthropology, and psycholinguistics" (p. 3). (Philosophy is noticeably missing from this list, but several aspects of the authors' stance indicate that it is not ignored.)

  2. The problem with emotion. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Bowling, Daniel L.

    2015-06-01

    In everyday use, emotion typically refers to conscious feelings. It feels like something to be happy or sad, afraid or angry. These emotions have qualia. That qualia are so central to what we mean by emotion makes emotion research both exciting and frustrating. Exciting because understanding how the brain gives rise to qualia is a fundamental goal of neuroscience, and frustrating because despite centuries of inquiry, qualia continue to defy a mechanistic explanation. But this obstacle has not completely blocked progress because there are other aspects of emotion - behavioral and physiological - that are more accessible to research, and the study of these has produced considerable advances in our understanding of how emotions work [13].

  3. What is reconfigured?. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Engelen, Eva-Maria

    2015-06-01

    The research group around Koelsch presents a neurobiological emotion theory that is supposed to have the following plus factors: (1) Interdisciplinary approach towards understanding human emotions and their neural correlates, (2) concentration on human emotions, (3) interaction between language and emotion, (4) allows research on short-term emotional phenomena and takes long-term emotional phenomena into account, as well as the differences of the neural correlates underlying short-term and long-term emotions [5]. This is a very ambitious program. My comment will focus on (3) and (4).

  4. "Anything is good that stimulates thought" in the hippocampus. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Hofmann, Markus J.; Kuchinke, Lars

    2015-06-01

    While the emotional trias of brainstem, diencephalon, and orbitofrontal cortex is generally accepted to hold an affective function at its core, fewer researchers would agree that the least common denominator function of the hippocampus is affective [1]. There is a greater consensus on complementary learning systems theory proposing that in contrast to the outer cerebral cortex hosting more stable memories, synaptic associations in the hippocampus create novel knowledge in the context of episodic memories [2]. We chose Oscar Wilde's quote [3, p. 108] as title because we think that the novel hippocampal conjunction of for the most part familiar (long-term) knowledge patterns elicits the positive affect of appreciation [4,5].

  5. Variability and situatedness of human emotions. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Nadal, Marcos; Rosselló, Jaume

    2015-06-01

    We commend Koelsch and colleagues [14] for developing a broad and integrative explanation of the neurobiological foundations of emotions. We especially welcome this framework's emphasis on the interaction between language and emotion, and its focus on the characteristically human moral emotions. Emotions elicited by art and aesthetics also seem to be distinctively human, but comparatively little research has been devoted to understanding these. This is probably because they are usually viewed as atypical in several respects. William James [12], for instance, regarded emotional responses to artworks and aesthetic qualities as subtler emotions, because they lacked the strong bodily changes and adaptive value characteristic of coarser emotions, such as joy, anger, or fear. This view is still predominant today, and aesthetic emotions are often distinguished from everyday emotions [13]. However, the notion of a class of aesthetic emotions, separate from everyday emotions, rests on the questionable assumption that artistic and aesthetic experiences and activities are different in essence from everyday experiences and activities. The discontinuity between "aesthetic experience [and] normal processes of living" [9, p. 10], however, is the product of social and cultural developments in Europe during the 18th century [7,15,20]. Distinctions that oppose art to craft, or aesthetic to practical, in reference to objects, behaviors, experiences, and emotions, make little sense in a broader historic and geographic context [1,7,20], and hinder empirical research [7].

  6. The attractive quartet potential energy surface for the CH(a{sup 4}{sigma}{sup {minus}}) + CO reaction: A role for the a {sup 4}A`` state of the ketenyl radical in combustion?

    Energy Technology Data Exchange (ETDEWEB)

    Schaefer, H.F. III [Univ. of Georgia, Athens (United States)

    1993-12-01

    Ab initio quantum mechanical techniques, including the self-consistent field (SCF), single and double excitation configuration interaction (CISD), single and double excitation double cluster (CCSD), and the single, double and perturbative triple excitation coupled cluster [CCSD(T)] methods have been applied to study the HCCO(a {sup 4}A{open_quotes}) energy hypersurface. Rate constant measurements suggest an attractive potential for the reaction of CH(a {sup 4}{sigma}{sup -}) with CO, and a vanishingly small energy barrier is predicted here in the CH(a {sup 4}{sigma}{sup -}) + CO reaction channel. The {sup 4}A{open_quotes} state of HCCO is predicted to be bound by about 30 kcal/mol with respect to separated CH(a {sup 4}{sigma}{sup -}) + CO. The authors propose that a spin-forbidden electronic deactivation of CH(a {sup 4}{sigma}{sup -}) might occur through through an intersystem crossing involving the {sup 4}A{open_quotes} state of HCCO. The energetics and the geometries of the reactants and products on both quartet and doublet energy surfaces are presented. The relationship between this research and experimental combustion chemistry has been explored.

  7. All the generalized Georgi-Machacek models

    CERN Document Server

    Logan, Heather E

    2015-01-01

    The Georgi-Machacek model adds two SU(2)_L-triplet scalars to the Standard Model in such a way as to preserve custodial SU(2) symmetry. We study the generalizations of the Georgi-Machacek model to SU(2)_L representations larger than triplets. Perturbative unitarity considerations limit the possibilities to models containing only SU(2)_L quartets, quintets, or sextets. These models are phenomenologically interesting because they allow the couplings of the 125 GeV Higgs boson to WW and ZZ to be larger than their values in the Standard Model. We write down the most general custodial SU(2)-preserving scalar potentials for these models and outline their phenomenology. We find that experimental and theoretical constraints on the fermiophobic custodial-fiveplet states present in each of the models lead to absolute upper bounds on the 125 GeV Higgs boson coupling strength to WW and ZZ.

  8. Ансамбль Xpress Quartet и художник Олег Высоцкий представили два своих новых альбома - музыкальный и художественный

    Index Scriptorium Estoniae

    2010-01-01

    Kunstnik Oleg Võssotski avas 4. detsembril Tallinna vanalinnas Valli tänav 4 oma maalide, akvarellide ja postkaartide müüginäituse. Samas presenteeriti ka Oleg Võssotski Venemaal ilmunud kunstialbumit "Дыхание Космоса". Avamisel esines ansambel Xpress Quartet. Ansambli juht on Oleg Võssotski poeg Vladimir Võssotski

  9. Big physics quartet win government backing

    Science.gov (United States)

    Banks, Michael

    2014-09-01

    Four major physics-based projects are among 10 to have been selected by Japan’s Ministry of Education, Culture, Sports, Science and Technology for funding in the coming decade as part of its “roadmap” of big-science projects.

  10. Place and Ethics in Lawrence Durrell' s The Alexandria Quartet%劳伦斯·达雷尔《亚历山大四重奏》中的场所与伦理释读

    Institute of Scientific and Technical Information of China (English)

    徐彬

    2012-01-01

    Contemporary British novelist Lawrence Durrell is highly commented by Western critics because of his depiction of exotic cultures, political crisis and historical responsibilities in The Alexandria Quartet. The sociological discussions on the relationships between man and place, and place and ethics provide perfect critical place and ethics in Durrell' s novel. Th paradigms for the interpretation of the relationship between e city of Alexandria is not a simple, inorganic physical ex- istence. It contains historical, cultural, literary and political elements and it has acquired a life within a grand historical narrative. Through the diachronic and synchronic description of Alexan- dria as a humanized place, Durrell reveals the influences of the ethical situation in the city on the ethical orientations of characters. Alexandria in a post-colonial context displays in the novel its unique ethical situation, in which Durrell presents both a fictional and a real reading about the ethical tag posted upon the ethical situation of the city and reveals the double attributes of the city' s ethical situation as an "ethical vacuum" and the place in which the subaltern speak.%英国现当代小说家劳伦斯·达雷尔以其代表作《亚历山大四重奏》的文化异质感、政治危机感和历史责任感而备受西方评论界的广泛关注。社会学中人与场所、场所与伦理之间关系的探讨为达雷尔小说中场所与伦理之间关系的释读提供了一个绝佳的批评范式。作为故事发生的场所,达雷尔笔下的亚历山大城不是一种简单、无机的物理存在,它集历史、文化、文学和政治等多重元素于一身,在宏大的历史叙事中获得了生命力。达雷尔通过对亚历山大被人化了的场所的共时性和历时性描述,揭示了城市伦理环境对人物伦理价值取向的影响。后殖民语境下的亚历山大为小说提供了一个独特的伦理环境,达雷尔不仅对加

  11. Predictive coding links perception, action, and learning to emotions in music. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Gebauer, L.; Kringelbach, M. L.; Vuust, P.

    2015-06-01

    The review by Koelsch and colleagues [1] offers a timely, comprehensive, and anatomically detailed framework for understanding the neural correlates of human emotions. The authors describe emotion in a framework of four affect systems, which are linked to effector systems, and higher order cognitive functions. This is elegantly demonstrated through the example of music; a realm for exploring emotions in a domain, that can be independent of language but still highly relevant for understanding human emotions [2].

  12. On the role of language from basic to cultural modulation of affect. Comment on "The quartet theory of human emotions: An integrative and neurofunctional model" by S. Koelsch et al.

    Science.gov (United States)

    Conrad, Markus

    2015-06-01

    Koelsch et al. [1] propose the following two emotion-relevant functions of language: "(a) With regard to subjective feelings, language is an important means to express as well as communicate emotions (and, therefore, also to elicit emotions in other individuals). (b) With regard to conscious appraisal, language is an important means to regulate emotions" - assuming that "activity of affect systems and effector systems is synthesized into an emotion percept (pre-verbal subjective feeling), which can be transformed (or reconfigured) into a symbolic code such as language".

  13. QuartetS: A Fast and Accurate Algorithm for Large-Scale Orthology Detection

    Science.gov (United States)

    2011-01-01

    genomic data to reveal the molecular functions of genes, their essentiality to a species survival and their connections to the virulence of pathogenic...i.e. orthologs) across different species often share equivalent molecular func- tions, orthology detection methods have become pivotal in helping...versus proteins. Genetica , 118, 209–216. 4. Serres,M.H., Kerr,A.R., McCormack,T.J. and Riley,M. (2009) Evolution by leaps: gene duplication in bacteria

  14. Analysis of the Compositional Style of Mozart’ s Late Piano Concertos and String Quartets%莫扎特晚期钢琴协奏曲与弦乐四重奏之展开部的研究与分析

    Institute of Scientific and Technical Information of China (English)

    张希

    2016-01-01

    莫扎特的钢琴协奏曲K�537和K�595与弦乐四重奏K�575和K�589是其晚年重要的器乐作品。在这四首作品中,特别是在它们的展开部中,莫扎特在调性、和声及织体的写作运用中继承并发展变革了前人及莫扎特本人早期的一些创作手法,展示了鲜明的晚期风格。%Mozart’ s Piano Concertos K. 537 and K. 595 and String Quartets K. 575 and K. 589 are his important late works. In these works, especially in their development sections, Mozart inherited some compositional style from his and other composer’ s earlier works, and also used many new ideas and techniques in these compositions. These compositions show many characteristics of Mozart’ s late style.

  15. High-order Boussinesq-type modelling of nonlinear wave phenomena in deep and shallow water

    DEFF Research Database (Denmark)

    Madsen, Per A.; Fuhrman, David R.

    2010-01-01

    In this work, we start with a review of the development of Boussinesq theory for water waves covering the period from 1872 to date. Previous reviews have been given by Dingemans,1 Kirby,2,3 and Madsen & Schäffer.4 Next, we present our most recent high-order Boussinesq-type formulation valid...... for fully nonlinear and highly dispersive waves traveling over a rapidly varying bathymetry. Finally, we cover applications of this Boussinesq model, and we study a number of nonlinear wave phenomena in deep and shallow water. These include (1) Kinematics in highly nonlinear progressive deep-water waves; (2......) Kinematics in progressive solitary waves; (3) Reflection of solitary waves from a vertical wall; (4) Reflection and diffraction around a vertical plate; (5) Quartet and quintet interactions and class I and II instabilities; (6) Extreme events from focused directionally spread waveelds; (7) Bragg scattering...

  16. High-order Boussinesq-type modelling of nonlinear wave phenomena in deep and shallow water

    DEFF Research Database (Denmark)

    Madsen, Per A.; Fuhrman, David R.

    2010-01-01

    In this work, we start with a review of the development of Boussinesq theory for water waves covering the period from 1872 to date. Previous reviews have been given by Dingemans,1 Kirby,2,3 and Madsen & Schäffer.4 Next, we present our most recent high-order Boussinesq-type formulation valid...... for fully nonlinear and highly dispersive waves traveling over a rapidly varying bathymetry. Finally, we cover applications of this Boussinesq model, and we study a number of nonlinear wave phenomena in deep and shallow water. These include (1) Kinematics in highly nonlinear progressive deep-water waves; (2......) Kinematics in progressive solitary waves; (3) Reflection of solitary waves from a vertical wall; (4) Reflection and diffraction around a vertical plate; (5) Quartet and quintet interactions and class I and II instabilities; (6) Extreme events from focused directionally spread waveelds; (7) Bragg scattering...

  17. A coarsening model for coherent precipitates

    Energy Technology Data Exchange (ETDEWEB)

    McCormack, Mark Thomas [Univ. of California, Berkeley, CA (United States)

    1991-12-01

    The morphological evolution of coherent inclusions in elastic media is studied in two-dimensions. The inclusions are simple dilations with isotropic surface energy in a system with homogeneous elastic constants of negative anisotropy. The equilibrium sizes at which a circular inclusion transforms to a rectangle or square, and at which a square splits into a doublet or quartet of separated inclusions are computed analytically. A finite-element model is then constructed to simulate the evolution of an arbitrary distribution of inclusions along the minimum-energy path. In the model, the circle evolves into a square, which splits into a doublet by hollowing from its center, or, if this is forbidden, by drawing in a perturbation on its surface. The sizes at which shapes spontaneously transform are compared to the equilibrium values. Finally, the simulation is used to study the evolution of a random distribution of inclusions. The first metastable state assumed by the distribution depends on the elastic interaction, surface energy and areal fraction of the inclusion phase through a single dimensionless parameter that groups these three effects. Results are compared to prior theoretical and experimental work on coarsening patterns in three dimensions.

  18. Diet, Microbiota, Obesity, and NAFLD: A Dangerous Quartet

    Directory of Open Access Journals (Sweden)

    Mariana Verdelho Machado

    2016-04-01

    Full Text Available Recently, the importance of the gut-liver-adipose tissue axis has become evident. Nonalcoholic fatty liver disease (NAFLD is the hepatic disease of a systemic metabolic disorder that radiates from energy-surplus induced adiposopathy. The gut microbiota has tremendous influences in our whole-body metabolism, and is crucial for our well-being and health. Microorganisms precede humans in more than 400 million years and our guest flora evolved with us in order to help us face aggressor microorganisms, to help us maximize the energy that can be extracted from nutrients, and to produce essential nutrients/vitamins that we are not equipped to produce. However, our gut microbiota can be disturbed, dysbiota, and become itself a source of stress and injury. Dysbiota may adversely impact metabolism and immune responses favoring obesity and obesity-related disorders such as insulin resistance/diabetes mellitus and NAFLD. In this review, we will summarize the latest evidence of the role of microbiota/dysbiota in diet-induced obesity and NAFLD, as well as the potential therapeutic role of targeting the microbiota in this set.

  19. The sweet quartet: Binding of fucose to the norovirus capsid.

    Science.gov (United States)

    Koromyslova, Anna D; Leuthold, Mila M; Bowler, Matthew W; Hansman, Grant S

    2015-09-01

    Human noroviruses bind histo-blood group antigens (HBGAs) and this interaction is thought to be important for an infection. We identified two additional fucose-binding pockets (termed fucose-3/4 sites) on a genogroup II human (GII.10) norovirus-protruding (P) dimer using X-ray crystallography. Fucose-3/4 sites were located between two previously determined HBGA binding pockets (termed fucose-1/2 sites). We found that four fucose molecules were capable of binding altogether at fucose-1/2/3/4 sites on the P dimer, though the fucose molecules bound in a dose-dependent and step-wise manner. We also showed that HBGA B-trisaccharide molecules bound in a similar way at the fucose-1/2 sites. Interestingly, we discovered that the monomers of the P dimer were asymmetrical in an unliganded state and when a single B-trisaccharide molecule bound, but were symmetrical when two B-trisaccharide molecules bound. We postulate that the symmetrical dimers might favor HBGA binding interactions at fucose-1/2 sites.

  20. Diet, Microbiota, Obesity, and NAFLD: A Dangerous Quartet.

    Science.gov (United States)

    Machado, Mariana Verdelho; Cortez-Pinto, Helena

    2016-04-01

    Recently, the importance of the gut-liver-adipose tissue axis has become evident. Nonalcoholic fatty liver disease (NAFLD) is the hepatic disease of a systemic metabolic disorder that radiates from energy-surplus induced adiposopathy. The gut microbiota has tremendous influences in our whole-body metabolism, and is crucial for our well-being and health. Microorganisms precede humans in more than 400 million years and our guest flora evolved with us in order to help us face aggressor microorganisms, to help us maximize the energy that can be extracted from nutrients, and to produce essential nutrients/vitamins that we are not equipped to produce. However, our gut microbiota can be disturbed, dysbiota, and become itself a source of stress and injury. Dysbiota may adversely impact metabolism and immune responses favoring obesity and obesity-related disorders such as insulin resistance/diabetes mellitus and NAFLD. In this review, we will summarize the latest evidence of the role of microbiota/dysbiota in diet-induced obesity and NAFLD, as well as the potential therapeutic role of targeting the microbiota in this set.

  1. Quartet: On the Theme of to Portray is to Betray

    Directory of Open Access Journals (Sweden)

    Paul Magee

    2013-09-01

    Full Text Available Art does not deceive its readers with an illusion of reality, as the common-sense notion has it, but rather pretends to deceive them. For the communicative power of the work of art lies precisely in the fact that we recognise its artificiality, its status as a work within a given genre, following certain conventions, set in a particular frame. What the work really points to, beyond the page, is the existence and actions of a creative consciousness, as that consciousness works through a given set of symbols to express itself. For reading is all about experiencing another’s mind. In the lack. Which makes it a matter of desire. My purpose in the following is to use literature to crack open the everyday, to write about neurosis and psychosis, how they write their way into the real world around us, the dinner table, this novel, a Greek tragedy, I mean Oedipus complex.

  2. Diet, Microbiota, Obesity, and NAFLD: A Dangerous Quartet

    Science.gov (United States)

    Machado, Mariana Verdelho; Cortez-Pinto, Helena

    2016-01-01

    Recently, the importance of the gut-liver-adipose tissue axis has become evident. Nonalcoholic fatty liver disease (NAFLD) is the hepatic disease of a systemic metabolic disorder that radiates from energy-surplus induced adiposopathy. The gut microbiota has tremendous influences in our whole-body metabolism, and is crucial for our well-being and health. Microorganisms precede humans in more than 400 million years and our guest flora evolved with us in order to help us face aggressor microorganisms, to help us maximize the energy that can be extracted from nutrients, and to produce essential nutrients/vitamins that we are not equipped to produce. However, our gut microbiota can be disturbed, dysbiota, and become itself a source of stress and injury. Dysbiota may adversely impact metabolism and immune responses favoring obesity and obesity-related disorders such as insulin resistance/diabetes mellitus and NAFLD. In this review, we will summarize the latest evidence of the role of microbiota/dysbiota in diet-induced obesity and NAFLD, as well as the potential therapeutic role of targeting the microbiota in this set. PMID:27043550

  3. Modeling and Simulations of Particulate Flows through Functionalized Porous Media

    Science.gov (United States)

    Li, Chunhui; Dutta, Prashanta; Liu, Jin

    2016-11-01

    Transport of particulate fluid through a functionalized porous material is of significant interest in many industrial applications, such as earth sciences, battery designs and water/air purifications. The entire process is complex, which involves the convection of fluid, diffusion of reactants as well as reversible chemical reactions at the fluid-solid interface In this work we present a convection-diffusion-reaction model and simulate the transport of particulate fluid through a functionalized porous media. The porous structures are generated and manipulated through the quartet structure generation set method. The Navier-Stokes with convection-diffusion equations are solved using the lattice Boltzmann method. The chemical reactions at the interface are modeled by an absorption-desorption process and treated as the boundary conditions for above governing equations. Through our simulations we study the effects of porous structures, including porosity, pore orientation, and pore size as well as the kinetic rates of surface reactions on the overall performance of removal efficiency of the species from the solution. Our results show that whole process is highly affected by both the porous structures and absorption rate. The optimal parameters can be achieved by proper design. This work is supported by NSF Grants: CBET-1250107 and CBET -1604211.

  4. Exploring non-covalent interactions in guanine- and xanthine-based model DNA quadruplex structures: a comprehensive quantum chemical approach.

    Science.gov (United States)

    Yurenko, Yevgen P; Novotný, Jan; Sklenář, Vladimir; Marek, Radek

    2014-02-07

    The study aimed to cast light on the structure and internal energetics of guanine- and xanthine-based model DNA quadruplexes and the physico-chemical nature of the non-covalent interactions involved. Several independent approaches were used for this purpose: DFT-D3 calculations, Quantum Theory of Atoms in Molecules, Natural Bond Orbital Analysis, Energy Decomposition Analysis, Compliance Constant Theory, and Non-Covalent Interaction Analysis. The results point to an excellent degree of structural and energetic compatibility between the two types of model quadruplexes. This fact stems from both the structural features (close values of van der Waals volumes, pore radii, geometrical parameters of the H-bonds) and the energetic characteristics (comparable values of the energies of formation). It was established that hydrogen bonding makes the greatest (∼50%) contribution to the internal stability of the DNA quadruplexes, whereas the aromatic base stacking and ion coordination terms are commensurable and account for the rest. Energy decomposition analysis performed for guanine (Gua) and xanthine (Xan) quartets B4 and higher-order structures consisting of two or three stacked quartets indicates that whereas Gua structures benefit from a high degree of H-bond cooperativity, Xan models are characterized by a more favorable and cooperative π-π stacking. The results of electron density topological analysis show that Na(+)/K(+) ion coordination deeply affects the network of non-covalent interactions in Gua models due to the change in the twist angle between the stacked tetrads. For Xan models, ion coordination makes tetrads in stacks more planar without changing the twist angle. Therefore, the presence of the ion seems to be essential for the formation of planar stacks in Xan-based DNA quadruplexes. Detailed study of the nature of ion-base coordination suggests that this interaction has a partially covalent character and cannot be considered as purely electrostatic

  5. Models

    DEFF Research Database (Denmark)

    Juel-Christiansen, Carsten

    2005-01-01

    Artiklen fremhæver den visuelle rotation - billeder, tegninger, modeller, værker - som det privilligerede medium i kommunikationen af ideer imellem skabende arkitekter......Artiklen fremhæver den visuelle rotation - billeder, tegninger, modeller, værker - som det privilligerede medium i kommunikationen af ideer imellem skabende arkitekter...

  6. Canonical Cortical Circuit Model Explains Rivalry, Intermittent Rivalry, and Rivalry Memory.

    Directory of Open Access Journals (Sweden)

    Shashaank Vattikuti

    2016-05-01

    Full Text Available It has been shown that the same canonical cortical circuit model with mutual inhibition and a fatigue process can explain perceptual rivalry and other neurophysiological responses to a range of static stimuli. However, it has been proposed that this model cannot explain responses to dynamic inputs such as found in intermittent rivalry and rivalry memory, where maintenance of a percept when the stimulus is absent is required. This challenges the universality of the basic canonical cortical circuit. Here, we show that by including an overlooked realistic small nonspecific background neural activity, the same basic model can reproduce intermittent rivalry and rivalry memory without compromising static rivalry and other cortical phenomena. The background activity induces a mutual-inhibition mechanism for short-term memory, which is robust to noise and where fine-tuning of recurrent excitation or inclusion of sub-threshold currents or synaptic facilitation is unnecessary. We prove existence conditions for the mechanism and show that it can explain experimental results from the quartet apparent motion illusion, which is a prototypical intermittent rivalry stimulus.

  7. Modelling

    CERN Document Server

    Spädtke, P

    2013-01-01

    Modeling of technical machines became a standard technique since computer became powerful enough to handle the amount of data relevant to the specific system. Simulation of an existing physical device requires the knowledge of all relevant quantities. Electric fields given by the surrounding boundary as well as magnetic fields caused by coils or permanent magnets have to be known. Internal sources for both fields are sometimes taken into account, such as space charge forces or the internal magnetic field of a moving bunch of charged particles. Used solver routines are briefly described and some bench-marking is shown to estimate necessary computing times for different problems. Different types of charged particle sources will be shown together with a suitable model to describe the physical model. Electron guns are covered as well as different ion sources (volume ion sources, laser ion sources, Penning ion sources, electron resonance ion sources, and H$^-$-sources) together with some remarks on beam transport.

  8. model

    African Journals Online (AJOL)

    trie neural construction oí inoiviouo! unci communal identities in ... occurs, Including models based on Information processing,1 ... Applying the DSM descriptive approach to dissociation in the ... a personal, narrative path lhal connects personal lo ethnic ..... managed the problem in the context of the community, using a.

  9. Remyelination induced by a DNA aptamer in a mouse model of multiple sclerosis.

    Directory of Open Access Journals (Sweden)

    Branislav Nastasijevic

    Full Text Available Multiple sclerosis (MS is a debilitating inflammatory disease of the central nervous system (CNS characterized by local destruction of the insulating myelin surrounding neuronal axons. With more than 200 million MS patients worldwide, the absence of treatments that prevent progression or induce repair poses a major challenge. Anti-inflammatory therapies have met with limited success only in preventing relapses. Previous screening of human serum samples revealed natural IgM antibodies that bind oligodendrocytes and promote both cell signaling and remyelination of CNS lesions in an MS model involving chronic infection of susceptible mice by Theiler's encephalomyelitis virus and in the lysolecithin model of focal demyelination. This intriguing result raises the possibility that molecules with binding specificity for oligodendrocytes or myelin components may promote therapeutic remyelination in MS. Because of the size and complexity of IgM antibodies, it is of interest to identify smaller myelin-specific molecules with the ability to promote remyelination in vivo. Here we show that a 40-nucleotide single-stranded DNA aptamer selected for affinity to murine myelin shows this property. This aptamer binds multiple myelin components in vitro. Peritoneal injection of this aptamer results in distribution to CNS tissues and promotes remyelination of CNS lesions in mice infected by Theiler's virus. Interestingly, the selected DNA aptamer contains guanosine-rich sequences predicted to induce folding involving guanosine quartet structures. Relative to monoclonal antibodies, DNA aptamers are small, stable, and non-immunogenic, suggesting new possibilities for MS treatment.

  10. Molybdenum Trihydride Complexes: Computational Model of Oxidatively Induced Reductive Elimination of Dihydrogen.

    Science.gov (United States)

    Szatkowski, Lukasz; Hall, Michael B

    2017-08-21

    Recent experimental work shows that the 18-electron molybdenum complexes (1,2,4-C5H2tBu3)Mo(PMe3)2H3 (Cp(tBu)MoH3) and (C5HiPr4)Mo(PMe3)2H3 (Cp(iPr)MoH3) undergo oxidatively induced reductive elimination of dihydrogen (H2), slowly forming the 15-electron monohydride species in tetrahydrofuran and acetonitrile. The 17-electron [Cp(tBu)MoH3](+) derivative was stable enough to be characterized by X-ray diffraction, while [Cp(iPr)MoH3](+) was not. Density functional theory calculations of the H2 elimination pathways for both complexes in the gas phase and in a continuum solvent model indicate that H2 elimination from [Cp(iPr)MoH3](+) has a lower barrier than that from [Cp(tBu)MoH3](+). Further, a specific solvent association, which is stronger for [Cp(tBu)MoH3](+) than for [Cp(iPr)MoH3](+), contributes to the stability of the former. In agreement with the experimental observations, the calculations predict that [Cp(tBu)MoH3](+) would be in a quartet state at room temperature and a doublet state at 4.2 K, while [Cp(iPr)MoH3](+) is in a doublet state even at room temperature.

  11. The Urlinie in Hindemith's String quartet op. 22, second movement / Timothy L. Jackson

    Index Scriptorium Estoniae

    Jackson, Timothy L.

    2008-01-01

    Hindemithi Neljanda keelpillikvarteti 2. osa muusikaanalüüs. Muusikalooline taust Paul Hindemithi, Heinrich Schenkeri, Wilhelm Furtwängleri, Bruno Stürmeri ja Gerhard Albersheimi kirjavahetuse varal. Artikli lõpus saksakeelsed originaalkirjad

  12. The Urlinie in Hindemith's String quartet op. 22, second movement / Timothy L. Jackson

    Index Scriptorium Estoniae

    Jackson, Timothy L.

    2008-01-01

    Hindemithi Neljanda keelpillikvarteti 2. osa muusikaanalüüs. Muusikalooline taust Paul Hindemithi, Heinrich Schenkeri, Wilhelm Furtwängleri, Bruno Stürmeri ja Gerhard Albersheimi kirjavahetuse varal. Artikli lõpus saksakeelsed originaalkirjad

  13. Galaxy evolution. Quasar quartet embedded in giant nebula reveals rare massive structure in distant universe.

    Science.gov (United States)

    Hennawi, Joseph F; Prochaska, J Xavier; Cantalupo, Sebastiano; Arrigoni-Battaia, Fabrizio

    2015-05-15

    All galaxies once passed through a hyperluminous quasar phase powered by accretion onto a supermassive black hole. But because these episodes are brief, quasars are rare objects typically separated by cosmological distances. In a survey for Lyman-α emission at redshift z ≈ 2, we discovered a physical association of four quasars embedded in a giant nebula. Located within a substantial overdensity of galaxies, this system is probably the progenitor of a massive galaxy cluster. The chance probability of finding a quadruple quasar is estimated to be ∼10(-7), implying a physical connection between Lyman-α nebulae and the locations of rare protoclusters. Our findings imply that the most massive structures in the distant universe have a tremendous supply (≃10(11) solar masses) of cool dense (volume density ≃ 1 cm(-3)) gas, which is in conflict with current cosmological simulations. Copyright © 2015, American Association for the Advancement of Science.

  14. Phased whole-genome genetic risk in a family quartet using a major allele reference sequence.

    Directory of Open Access Journals (Sweden)

    Frederick E Dewey

    2011-09-01

    Full Text Available Whole-genome sequencing harbors unprecedented potential for characterization of individual and family genetic variation. Here, we develop a novel synthetic human reference sequence that is ethnically concordant and use it for the analysis of genomes from a nuclear family with history of familial thrombophilia. We demonstrate that the use of the major allele reference sequence results in improved genotype accuracy for disease-associated variant loci. We infer recombination sites to the lowest median resolution demonstrated to date (< 1,000 base pairs. We use family inheritance state analysis to control sequencing error and inform family-wide haplotype phasing, allowing quantification of genome-wide compound heterozygosity. We develop a sequence-based methodology for Human Leukocyte Antigen typing that contributes to disease risk prediction. Finally, we advance methods for analysis of disease and pharmacogenomic risk across the coding and non-coding genome that incorporate phased variant data. We show these methods are capable of identifying multigenic risk for inherited thrombophilia and informing the appropriate pharmacological therapy. These ethnicity-specific, family-based approaches to interpretation of genetic variation are emblematic of the next generation of genetic risk assessment using whole-genome sequencing.

  15. World Cup 2006: the "magic quartet" and the analytical categories of brazilian soccer

    OpenAIRE

    Castellani,Rafael Moreno; Braga, Harian Pires

    2016-01-01

    http://dx.doi.org/10.5007/2175-8042.2016v28n49p54The World Cup has the ability to mobilize communities around the world besides gathering through soccer meanings that would allow buildings of identities. Thereby, this study had as objective identify and think over analytical categories about soccer used by sports media during the journalistic coverage of 2006 World Cup. The main thing that contributed to our choice for this edition was the recovery of recurrent categories of Brazilian soccer,...

  16. Algorithms for Computing the Triplet and Quartet Distances for Binary and General Trees

    DEFF Research Database (Denmark)

    Sand, Andreas; Holt, Morten Kragelund; Johansen, Jens;

    2013-01-01

    , respectively, where the topologies of the induced subtrees differ. These distances can trivially be computed by explicitly enumerating all sets of three or four leaves and testing if the topologies are different, but this leads to time complexities at least of the order n3 or n4 just for enumerating the sets....... The different topologies can be counted implicitly, however, and in this paper, we review a series of algorithmic improvements that have been used during the last decade to develop more efficient algorithms by exploiting two different strategies for this; one based on dynamic programming and another based...

  17. Quasar Quartet Embedded in Giant Nebula Reveals Rare Massive Structure in Distant Universe

    CERN Document Server

    Hennawi, Joseph F; Cantalupo, Sebastiano; Arrigoni-Battaia, Fabrizio

    2015-01-01

    All galaxies once passed through a hyperluminous quasar phase powered by accretion onto a supermassive black hole. But because these episodes are brief, quasars are rare objects typically separated by cosmological distances. In a survey for Lyman-alpha emission at redshift z ~ 2, we discovered a physical association of four quasars embedded in a giant nebula. Located within a substantial overdensity of galaxies, this system is probably the progenitor of a massive galaxy cluster. The chance probability of finding a quadruple quasar is estimated to be ~10^-7, implying a physical connection between Lyman-alpha nebulae and the locations of rare protoclusters. Our findings imply that the most massive structures in the distant universe have a tremendous supply (~ 10^11 solar masses) of cool dense (volume density ~1 cm^-3) gas, which is in conflict with current cosmological simulations.

  18. Using the Knowledge Quartet to Develop Mathematics Content Knowledge: The Role of Reflection on Professional Development

    Science.gov (United States)

    Turner, Fay

    2012-01-01

    In this paper I report findings from a four year study of beginning elementary school teachers which investigated development in their mathematical knowledge for teaching (MKT). The study took a developmental research approach, in that the teachers and the researcher collaborated to develop the mathematics teaching of the teachers, while also…

  19. Targeting Stat3 With G-Quartet Oligonucleotides in Metastatic Prostate Cancer

    Science.gov (United States)

    2005-04-01

    and potentially promising class of drug 24. Burdelya L, Catlett-Falcone R, Levitzki A, et al. Combination therapy with AG-490 and interleukin 12...growth and Sci USA 2000; 97: 4227-32. transformation: recent discoveries lead to new insights. FASEB J [63] Burdelya L, Catlett-Falcone R, Levitzki A

  20. Rumba, Salsa, Samba and Tango in the magnetosphere - the Cluster quartet's first year in space

    Science.gov (United States)

    Escoubet, C. P.; Fehringer, M.; Bond, P.

    2001-08-01

    This is the first time that the Earth's magnetic field and its environment have been explored by a small constellation of four identical spacecraft. Preliminary results show that, as predicted, with four spacecraft we can obtain a detailed three-dimensional view of the Sun-Earth connection processes taking place at the interface between the solar wind and the Earth's magnetic field.

  1. Orchestration of an uncommon maturation cascade of the house dust mite protease allergen quartet

    Directory of Open Access Journals (Sweden)

    Marie-Eve eDumez

    2014-03-01

    Full Text Available In more than 20% of the world population, sensitization to house dust mite (HDM allergens triggers typical allergic diseases such as allergic rhinitis and asthma. Amongst the 23 mite allergen groups hitherto identified, groups 1 are cysteine proteases belonging to the papain-like family whereas groups 3, 6 and 9 are serine proteases displaying trypsin, chymotrypsin and collagenolytic activities, respectively. While these proteases are more likely to be involved in the mite digestive system, they also play critical roles in the initiation and in the chronicity of the allergic response notably through the activation of innate immune pathways. All these allergenic proteases are expressed in mite as inactive precursor form. Until recently, the exact mechanisms of their maturation into active proteases remained to be fully elucidated. Recent breakthroughs in the understanding of the activation mechanisms of mite allergenic protease precursors have highlighted an uncommon and unique maturation pathway orchestrated by group 1 proteases that tightly regulates the proteolytic activities of groups 1, 3, 6 and 9 through complex intra- or intermolecular mechanisms. This review presents and discusses the currently available knowledge of the activation mechanisms of group 1, 3, 6 and 9 allergens of Dermatophagoides pteronyssinus laying special emphasis on their localization, regulation and interconnection.

  2. Numerical Modeling of Two-Phase Hydromagnetic Flow and Heat Transfer in a Particle-Suspension through a non-Darcian Porous Channel

    Directory of Open Access Journals (Sweden)

    . Dr. S. Rawat

    2014-01-01

    Full Text Available A mathematical model is presented for the steady, two-dimensional magneto-convection heat transfer of a two-phase, electrically-conducting, particle-suspension in a channel containing a non-Darcian porous medium intercalated between two parallel plates, in the presence of a transverse magnetic field. The channel walls are assumed to be isothermal but at different temperatures. The governing equations for the one-dimensional steady flow are formulated following Marble (1970 and extended to include the influence of Darcian porous drag, Forcheimmer quadratic drag, buoyancy effects, Lorentz body force (hydromagnetic retardation force and particle-phase viscous stresses. Special boundary conditions for the particle-phase wall conditions are implemented. The governing coupled, non-linear differential equations are reduced from an (x,y coordinate system to a one-dimensional (y coordinate system. A series of transformations is then employed to non-dimensionalize the model in terms of a single independent variable, , yielding a quartet of coupled ordinary differential equations which are solved numerically using the finite element method, under appropriate transformed boundary conditions. The influence of for example Grashof free convection number (Gr, Hartmann hydromagnetic number (Ha, inverse Stokes number (Skm, Darcy number (Da, Forcheimmer number (Fs,particle loading parameter (PL, buoyancy parameter (B on the fluid-phase velocity and particle-phase velocity are presented graphically. A number of special cases of the transformed model are also studied. The mathematical model finds applications in solar collector devices, electronic fabrication, jet nozzle flows, industrial materials processing transport phenomena, MHD energy generator systems etc.

  3. Misleading Betas: An Educational Example

    Science.gov (United States)

    Chong, James; Halcoussis, Dennis; Phillips, G. Michael

    2012-01-01

    The dual-beta model is a generalization of the CAPM model. In the dual-beta model, separate beta estimates are provided for up-market and down-market days. This paper uses the historical "Anscombe quartet" results which illustrated how very different datasets can produce the same regression coefficients to motivate a discussion of the…

  4. Knowledge Quartet’s Unit of Contingency in the Light of Mathematics Content Knowledge

    Directory of Open Access Journals (Sweden)

    Semiha Kula

    2014-04-01

    Full Text Available The purpose of this study is to introduce the Contingency unit of Knowledge Quartet, which is a framework used in assessing mathematics student teachers’ subject matter knowledge and pedagogical knowledge, address its significance and demonstrate examples from its reflections on classroom setting. The study initially covers the type of knowledge that teachers should possess and Knowledge Quartet, which enables examining and assessing subject matter knowledge and pedagogical knowledge together. Next, general information was given regarding knowledge units of this model and it was explained including contingency components. Finally, the importance of Contingency was mentioned and some examples in classroom setting were discussed. It is thought that through this study, awareness of mathematics student teachers can be made ensured with regards to situations that teachers may encounter and that are almost impossible to plan in advance.Key Words:    Contingency, knowledge quartet, mathematics student teacher, subject matter knowledge, pedagogical content knowledge

  5. Bela Bartok's String Quartet's Melodic Thought%巴托克弦乐四重奏的旋律思维

    Institute of Scientific and Technical Information of China (English)

    周雪石

    2001-01-01

    就技术层面而言,巴托克独树一帜的音乐风格,源于他极其个性化的音高体系,已成为中外音乐理论家的共识.本文在已有成果的基础上,以巴托克的弦乐四重奏为对象,着重探讨旋律构成中的调式结构,提出了同基音场综合调式、泛调式、十二声调式等概念,希望通过某些具体的技术环节,尽可能准确地理解巴托克的重奏音乐.

  6. QuartetS-DB: A Large-Scale Orthology Database for Prokaryotes and Eukaryotes Inferred by Evolutionary Evidence

    Science.gov (United States)

    2012-01-01

    669 Firmicutes (B) 303 Actinobacteria (B) 137 Euryarchaeota (A) 60 Bacteroidetes (B) 57 Ascomycota (E) 51 Cyanobacteria (B) 44 Crenarchaeota (A) 28...manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color figure

  7. Leadership Models.

    Science.gov (United States)

    Freeman, Thomas J.

    This paper discusses six different models of organizational structure and leadership, including the scalar chain or pyramid model, the continuum model, the grid model, the linking pin model, the contingency model, and the circle or democratic model. Each model is examined in a separate section that describes the model and its development, lists…

  8. Model Transformations? Transformation Models!

    NARCIS (Netherlands)

    Bézivin, J.; Büttner, F.; Gogolla, M.; Jouault, F.; Kurtev, I.; Lindow, A.

    2006-01-01

    Much of the current work on model transformations seems essentially operational and executable in nature. Executable descriptions are necessary from the point of view of implementation. But from a conceptual point of view, transformations can also be viewed as descriptive models by stating only the

  9. Modelling business models

    NARCIS (Netherlands)

    Simonse, W.L.

    2014-01-01

    Business model design does not always produce a “design” or “model” as the expected result. However, when designers are involved, a visual model or artifact is produced. To assist strategic managers in thinking about how they can act, the designers’ challenge is to combine both strategy and design n

  10. Modelling SDL, Modelling Languages

    Directory of Open Access Journals (Sweden)

    Michael Piefel

    2007-02-01

    Full Text Available Today's software systems are too complex to implement them and model them using only one language. As a result, modern software engineering uses different languages for different levels of abstraction and different system aspects. Thus to handle an increasing number of related or integrated languages is the most challenging task in the development of tools. We use object oriented metamodelling to describe languages. Object orientation allows us to derive abstract reusable concept definitions (concept classes from existing languages. This language definition technique concentrates on semantic abstractions rather than syntactical peculiarities. We present a set of common concept classes that describe structure, behaviour, and data aspects of high-level modelling languages. Our models contain syntax modelling using the OMG MOF as well as static semantic constraints written in OMG OCL. We derive metamodels for subsets of SDL and UML from these common concepts, and we show for parts of these languages that they can be modelled and related to each other through the same abstract concepts.

  11. Pop / Raul Saaremets

    Index Scriptorium Estoniae

    Saaremets, Raul

    2002-01-01

    Heliplaatidest Starsailor" Love is Here". Chicago Underground Quartet "Chicago Underground Quartet". Mower "Mower". Kim Wilde "The Very Best of". Mull Historical Society "Loss". Jill Scott "Experience: 826+"

  12. Pop / Raul Saaremets

    Index Scriptorium Estoniae

    Saaremets, Raul

    2002-01-01

    Heliplaatidest Starsailor" Love is Here". Chicago Underground Quartet "Chicago Underground Quartet". Mower "Mower". Kim Wilde "The Very Best of". Mull Historical Society "Loss". Jill Scott "Experience: 826+"

  13. Actant Models

    DEFF Research Database (Denmark)

    Poulsen, Helle

    1996-01-01

    This paper presents a functional modelling method called Actant Modelling rooted in linguistics and semiotics. Actant modelling can be integrated with Multilevel Flow Modelling (MFM) in order to give an interpretation of actants.......This paper presents a functional modelling method called Actant Modelling rooted in linguistics and semiotics. Actant modelling can be integrated with Multilevel Flow Modelling (MFM) in order to give an interpretation of actants....

  14. Modelling the models

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    By analysing the production of mesons in the forward region of LHC proton-proton collisions, the LHCf collaboration has provided key information needed to calibrate extremely high-energy cosmic ray models.   Average transverse momentum (pT) as a function of rapidity loss ∆y. Black dots represent LHCf data and the red diamonds represent SPS experiment UA7 results. The predictions of hadronic interaction models are shown by open boxes (sibyll 2.1), open circles (qgsjet II-03) and open triangles (epos 1.99). Among these models, epos 1.99 shows the best overall agreement with the LHCf data. LHCf is dedicated to the measurement of neutral particles emitted at extremely small angles in the very forward region of LHC collisions. Two imaging calorimeters – Arm1 and Arm2 – take data 140 m either side of the ATLAS interaction point. “The physics goal of this type of analysis is to provide data for calibrating the hadron interaction models – the well-known &...

  15. Modelling Practice

    DEFF Research Database (Denmark)

    2011-01-01

    This chapter deals with the practicalities of building, testing, deploying and maintaining models. It gives specific advice for each phase of the modelling cycle. To do this, a modelling framework is introduced which covers: problem and model definition; model conceptualization; model data...... requirements; model construction; model solution; model verification; model validation and finally model deployment and maintenance. Within the adopted methodology, each step is discussedthrough the consideration of key issues and questions relevant to the modelling activity. Practical advice, based on many...... years of experience is providing in directing the reader in their activities.Traps and pitfalls are discussed and strategies also given to improve model development towards “fit-for-purpose” models. The emphasis in this chapter is the adoption and exercise of a modelling methodology that has proven very...

  16. Promoting Models

    Science.gov (United States)

    Li, Qin; Zhao, Yongxin; Wu, Xiaofeng; Liu, Si

    There can be multitudinous models specifying aspects of the same system. Each model has a bias towards one aspect. These models often override in specific aspects though they have different expressions. A specification written in one model can be refined by introducing additional information from other models. The paper proposes a concept of promoting models which is a methodology to obtain refinements with support from cooperating models. It refines a primary model by integrating the information from a secondary model. The promotion principle is not merely an academic point, but also a reliable and robust engineering technique which can be used to develop software and hardware systems. It can also check the consistency between two specifications from different models. A case of modeling a simple online shopping system with the cooperation of the guarded design model and CSP model illustrates the practicability of the promotion principle.

  17. Cadastral Modeling

    DEFF Research Database (Denmark)

    Stubkjær, Erik

    2005-01-01

    Modeling is a term that refers to a variety of efforts, including data and process modeling. The domain to be modeled may be a department, an organization, or even an industrial sector. E-business presupposes the modeling of an industrial sector, a substantial task. Cadastral modeling compares to...

  18. 外交事务中的控制力模型及其在中国外交中的应用%Model of control power of foreign affairs and its application in China

    Institute of Scientific and Technical Information of China (English)

    吴殿廷; 王永明; 吴迪; 赵林

    2016-01-01

    By building models of control power of bilateral diplomacy and mul-tilateral diplomacy, this paper calculates relative control of typical diplo-matic spheres of China, and points out key things of China's diplomatic work. The result shows that in the bilateral diplomacy, control power of China is almost equivalent with Japan and Russia, slightly higher than South Korea, much higher than India, and Pakistan, but much lower than that of the United States. These state have a direct effect on bargaining power of China with these countries. Consider three-way diplomacy, in China - Japan - South Korea relations, China has considerable initiative, Japan is passive. In Chi-na-Japan- United States, China is passive. In the China -United States - Rus-sia, cooperation between China and Russia make position of United States weak-ened. In China-India-Pakistan, the join of Pakistan greatly increase the con-trol power of China. In quartet and even more relationship, cooperation of China and Russia is good for China.%构建了双边外交、多边外交的控制力模型,计算了中国典型外交圈层的相对控制力,指出中国外交工作的关键点。在双边外交中,中国的控制力与日本、俄罗斯大体相当,比韩国略高,比印度、巴基斯坦高很多,但比美国低很多。在三方外交中,中-日-韩关系中,中国占据相当大的主动权,而日本被动;但中-日-美关系中,中国被动;在中-美-俄关系中,中俄合作使美国优势地位削弱;中-印-巴关系中,巴基斯坦的进入会大大增强中国的控制力。在四方和更多方的关系中,中俄合作对中国有益。

  19. Model Warehouse

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    This paper puts forward a new conception:model warehouse,analyzes the reason why model warehouse appears and introduces the characteristics and architecture of model warehouse.Last,this paper points out that model warehouse is an important part of WebGIS.

  20. Constitutive Models

    DEFF Research Database (Denmark)

    2011-01-01

    procedure is introduced for the analysis and solution of property models. Models that capture and represent the temperature dependent behaviour of physical properties are introduced, as well as equation of state models (EOS) such as the SRK EOS. Modelling of liquid phase activity coefficients are also......This chapter presents various types of constitutive models and their applications. There are 3 aspects dealt with in this chapter, namely: creation and solution of property models, the application of parameter estimation and finally application examples of constitutive models. A systematic...... covered, illustrating several models such as the Wilson equation and NRTL equation, along with their solution strategies. A section shows how to use experimental data to regress the property model parameters using a least squares approach. A full model analysis is applied in each example that discusses...

  1. Model cities

    OpenAIRE

    Batty, M.

    2007-01-01

    The term ?model? is now central to our thinking about how weunderstand and design cities. We suggest a variety of ways inwhich we use ?models?, linking these ideas to Abercrombie?sexposition of Town and Country Planning which represented thestate of the art fifty years ago. Here we focus on using models asphysical representations of the city, tracing the development ofsymbolic models where the focus is on simulating how functiongenerates form, to iconic models where the focus is on representi...

  2. Model theory

    CERN Document Server

    Chang, CC

    2012-01-01

    Model theory deals with a branch of mathematical logic showing connections between a formal language and its interpretations or models. This is the first and most successful textbook in logical model theory. Extensively updated and corrected in 1990 to accommodate developments in model theoretic methods - including classification theory and nonstandard analysis - the third edition added entirely new sections, exercises, and references. Each chapter introduces an individual method and discusses specific applications. Basic methods of constructing models include constants, elementary chains, Sko

  3. Event Modeling

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2001-01-01

    The purpose of this chapter is to discuss conceptual event modeling within a context of information modeling. Traditionally, information modeling has been concerned with the modeling of a universe of discourse in terms of information structures. However, most interesting universes of discourse...... are dynamic and we present a modeling approach that can be used to model such dynamics. We characterize events as both information objects and change agents (Bækgaard 1997). When viewed as information objects events are phenomena that can be observed and described. For example, borrow events in a library can...

  4. Event Modeling

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2001-01-01

    The purpose of this chapter is to discuss conceptual event modeling within a context of information modeling. Traditionally, information modeling has been concerned with the modeling of a universe of discourse in terms of information structures. However, most interesting universes of discourse...... are dynamic and we present a modeling approach that can be used to model such dynamics.We characterize events as both information objects and change agents (Bækgaard 1997). When viewed as information objects events are phenomena that can be observed and described. For example, borrow events in a library can...

  5. Numerical models

    Digital Repository Service at National Institute of Oceanography (India)

    Unnikrishnan, A; Manoj, N.T.

    Various numerical models used to study the dynamics and horizontal distribution of salinity in Mandovi-Zuari estuaries, Goa, India is discussed in this chapter. Earlier, a one-dimensional network model was developed for representing the complex...

  6. Computable models

    CERN Document Server

    Turner, Raymond

    2009-01-01

    Computational models can be found everywhere in present day science and engineering. In providing a logical framework and foundation for the specification and design of specification languages, Raymond Turner uses this framework to introduce and study computable models. In doing so he presents the first systematic attempt to provide computational models with a logical foundation. Computable models have wide-ranging applications from programming language semantics and specification languages, through to knowledge representation languages and formalism for natural language semantics. They are al

  7. MODELING CONSCIOUSNESS

    OpenAIRE

    Taylor, J G

    2009-01-01

    We present tentative answers to three questions: firstly, what is to be assumed about the structure of the brain in attacking the problem of modeling consciousness; secondly, what is it about consciousness that is attempting to be modeled; and finally, what is taken on board the modeling enterprise, if anything, from the vast works by philosophers about the nature of mind.

  8. Zeebrugge Model

    DEFF Research Database (Denmark)

    Sclütter, Flemming; Frigaard, Peter; Liu, Zhou

    This report presents the model test results on wave run-up on the Zeebrugge breakwater under the simulated prototype storms. The model test was performed in January 2000 at the Hydraulics & Coastal Engineering Laboratory, Aalborg University. The detailed description of the model is given...

  9. Interface models

    DEFF Research Database (Denmark)

    Ravn, Anders P.; Staunstrup, Jørgen

    1994-01-01

    This paper proposes a model for specifying interfaces between concurrently executing modules of a computing system. The model does not prescribe a particular type of communication protocol and is aimed at describing interfaces between both software and hardware modules or a combination of the two....... The model describes both functional and timing properties of an interface...

  10. Constitutive Models

    DEFF Research Database (Denmark)

    2011-01-01

    This chapter presents various types of constitutive models and their applications. There are 3 aspects dealt with in this chapter, namely: creation and solution of property models, the application of parameter estimation and finally application examples of constitutive models. A systematic...

  11. BRST quantization of a sixth-order derivative scalar field theory

    OpenAIRE

    Kim, Yong-Wan; Myung, Yun Soo; Park, Young-Jai

    2013-01-01

    We study a sixth order derivative scalar field model in Minkowski spacetime as a toy model of higher-derivative critical gravity theories. This model is consistently quantized when using the Becchi-Rouet-Stora-Tyutin (BRST) quantization scheme even though it does not show gauge symmetry manifestly. Imposing a BRST quartet generated by two scalars and ghosts, there remains a non-trivial subspace with positive norm. This might be interpreted as a Minkowskian dual version of the unitary truncati...

  12. Model Experiments and Model Descriptions

    Science.gov (United States)

    Jackman, Charles H.; Ko, Malcolm K. W.; Weisenstein, Debra; Scott, Courtney J.; Shia, Run-Lie; Rodriguez, Jose; Sze, N. D.; Vohralik, Peter; Randeniya, Lakshman; Plumb, Ian

    1999-01-01

    The Second Workshop on Stratospheric Models and Measurements Workshop (M&M II) is the continuation of the effort previously started in the first Workshop (M&M I, Prather and Remsberg [1993]) held in 1992. As originally stated, the aim of M&M is to provide a foundation for establishing the credibility of stratospheric models used in environmental assessments of the ozone response to chlorofluorocarbons, aircraft emissions, and other climate-chemistry interactions. To accomplish this, a set of measurements of the present day atmosphere was selected. The intent was that successful simulations of the set of measurements should become the prerequisite for the acceptance of these models as having a reliable prediction for future ozone behavior. This section is divided into two: model experiment and model descriptions. In the model experiment, participant were given the charge to design a number of experiments that would use observations to test whether models are using the correct mechanisms to simulate the distributions of ozone and other trace gases in the atmosphere. The purpose is closely tied to the needs to reduce the uncertainties in the model predicted responses of stratospheric ozone to perturbations. The specifications for the experiments were sent out to the modeling community in June 1997. Twenty eight modeling groups responded to the requests for input. The first part of this section discusses the different modeling group, along with the experiments performed. Part two of this section, gives brief descriptions of each model as provided by the individual modeling groups.

  13. Scalable Models Using Model Transformation

    Science.gov (United States)

    2008-07-13

    and the following companies: Agilent, Bosch, HSBC , Lockheed-Martin, National Instruments, and Toyota. Scalable Models Using Model Transformation...parametrization, and workflow automation. (AFRL), the State of California Micro Program, and the following companies: Agi- lent, Bosch, HSBC , Lockheed

  14. Cadastral Modeling

    DEFF Research Database (Denmark)

    Stubkjær, Erik

    2005-01-01

    to the modeling of an industrial sector, as it aims at rendering the basic concepts that relate to the domain of real estate and the pertinent human activities. The palpable objects are pieces of land and buildings, documents, data stores and archives, as well as persons in their diverse roles as owners, holders...... to land. The paper advances the position that cadastral modeling has to include not only the physical objects, agents, and information sets of the domain, but also the objectives or requirements of cadastral systems.......Modeling is a term that refers to a variety of efforts, including data and process modeling. The domain to be modeled may be a department, an organization, or even an industrial sector. E-business presupposes the modeling of an industrial sector, a substantial task. Cadastral modeling compares...

  15. Modelling in Business Model design

    NARCIS (Netherlands)

    Simonse, W.L.

    2013-01-01

    It appears that business model design might not always produce a design or model as the expected result. However when designers are involved, a visual model or artefact is produced. To assist strategic managers in thinking about how they can act, the designers challenge is to combine strategy and

  16. Climate Models

    Science.gov (United States)

    Druyan, Leonard M.

    2012-01-01

    Climate models is a very broad topic, so a single volume can only offer a small sampling of relevant research activities. This volume of 14 chapters includes descriptions of a variety of modeling studies for a variety of geographic regions by an international roster of authors. The climate research community generally uses the rubric climate models to refer to organized sets of computer instructions that produce simulations of climate evolution. The code is based on physical relationships that describe the shared variability of meteorological parameters such as temperature, humidity, precipitation rate, circulation, radiation fluxes, etc. Three-dimensional climate models are integrated over time in order to compute the temporal and spatial variations of these parameters. Model domains can be global or regional and the horizontal and vertical resolutions of the computational grid vary from model to model. Considering the entire climate system requires accounting for interactions between solar insolation, atmospheric, oceanic and continental processes, the latter including land hydrology and vegetation. Model simulations may concentrate on one or more of these components, but the most sophisticated models will estimate the mutual interactions of all of these environments. Advances in computer technology have prompted investments in more complex model configurations that consider more phenomena interactions than were possible with yesterday s computers. However, not every attempt to add to the computational layers is rewarded by better model performance. Extensive research is required to test and document any advantages gained by greater sophistication in model formulation. One purpose for publishing climate model research results is to present purported advances for evaluation by the scientific community.

  17. Mathematical modelling

    CERN Document Server

    2016-01-01

    This book provides a thorough introduction to the challenge of applying mathematics in real-world scenarios. Modelling tasks rarely involve well-defined categories, and they often require multidisciplinary input from mathematics, physics, computer sciences, or engineering. In keeping with this spirit of modelling, the book includes a wealth of cross-references between the chapters and frequently points to the real-world context. The book combines classical approaches to modelling with novel areas such as soft computing methods, inverse problems, and model uncertainty. Attention is also paid to the interaction between models, data and the use of mathematical software. The reader will find a broad selection of theoretical tools for practicing industrial mathematics, including the analysis of continuum models, probabilistic and discrete phenomena, and asymptotic and sensitivity analysis.

  18. Turbulence Model

    DEFF Research Database (Denmark)

    Nielsen, Mogens Peter; Shui, Wan; Johansson, Jens

    2011-01-01

    In this report a new turbulence model is presented.In contrast to the bulk of modern work, the model is a classical continuum model with a relatively simple constitutive equation. The constitutive equation is, as usual in continuum mechanics, entirely empirical. It has the usual Newton or Stokes...... term with stresses depending linearly on the strain rates. This term takes into account the transfer of linear momentum from one part of the fluid to another. Besides there is another term, which takes into account the transfer of angular momentum. Thus the model implies a new definition of turbulence....... The model is in a virgin state, but a number of numerical tests have been carried out with good results. It is published to encourage other researchers to study the model in order to find its merits and possible limitations....

  19. Mathematical modelling

    DEFF Research Database (Denmark)

    Blomhøj, Morten

    2004-01-01

    Developing competences for setting up, analysing and criticising mathematical models are normally seen as relevant only from and above upper secondary level. The general belief among teachers is that modelling activities presuppose conceptual understanding of the mathematics involved. Mathematical...... modelling, however, can be seen as a practice of teaching that place the relation between real life and mathematics into the centre of teaching and learning mathematics, and this is relevant at all levels. Modelling activities may motivate the learning process and help the learner to establish cognitive...... roots for the construction of important mathematical concepts. In addition competences for setting up, analysing and criticising modelling processes and the possible use of models is a formative aim in this own right for mathematics teaching in general education. The paper presents a theoretical...

  20. Spherical models

    CERN Document Server

    Wenninger, Magnus J

    2012-01-01

    Well-illustrated, practical approach to creating star-faced spherical forms that can serve as basic structures for geodesic domes. Complete instructions for making models from circular bands of paper with just a ruler and compass. Discusses tessellation, or tiling, and how to make spherical models of the semiregular solids and concludes with a discussion of the relationship of polyhedra to geodesic domes and directions for building models of domes. "". . . very pleasant reading."" - Science. 1979 edition.

  1. Zeebrugge Model

    DEFF Research Database (Denmark)

    Liu, Zhou; Frigaard, Peter

    This report presents the model on wave run-up and run-down on the Zeebrugge breakwater under short-crested oblique wave attacks. The model test was performed in March-April 2000 at the Hydraulics & Coastal Engineering Laboratory, Aalborg University.......This report presents the model on wave run-up and run-down on the Zeebrugge breakwater under short-crested oblique wave attacks. The model test was performed in March-April 2000 at the Hydraulics & Coastal Engineering Laboratory, Aalborg University....

  2. Stream Modelling

    DEFF Research Database (Denmark)

    Vestergaard, Kristian

    the engineers, but as the scale and the complexity of the hydraulic works increased, the mathematical models became so complex that a mathematical solution could not be obtained. This created a demand for new methods and again the experimental investigation became popular, but this time as measurements on small......-scale models. But still the scale and complexity of hydraulic works were increasing, and soon even small-scale models reached a natural limit for some applications. In the mean time the modern computer was developed, and it became possible to solve complex mathematical models by use of computer-based numerical...

  3. Ventilation Model

    Energy Technology Data Exchange (ETDEWEB)

    V. Chipman

    2002-10-05

    The purpose of the Ventilation Model is to simulate the heat transfer processes in and around waste emplacement drifts during periods of forced ventilation. The model evaluates the effects of emplacement drift ventilation on the thermal conditions in the emplacement drifts and surrounding rock mass, and calculates the heat removal by ventilation as a measure of the viability of ventilation to delay the onset of peak repository temperature and reduce its magnitude. The heat removal by ventilation is temporally and spatially dependent, and is expressed as the fraction of heat carried away by the ventilation air compared to the fraction of heat produced by radionuclide decay. One minus the heat removal is called the wall heat fraction, or the remaining amount of heat that is transferred via conduction to the surrounding rock mass. Downstream models, such as the ''Multiscale Thermohydrologic Model'' (BSC 2001), use the wall heat fractions as outputted from the Ventilation Model to initialize their post-closure analyses. The Ventilation Model report was initially developed to analyze the effects of preclosure continuous ventilation in the Engineered Barrier System (EBS) emplacement drifts, and to provide heat removal data to support EBS design. Revision 00 of the Ventilation Model included documentation of the modeling results from the ANSYS-based heat transfer model. The purposes of Revision 01 of the Ventilation Model are: (1) To validate the conceptual model for preclosure ventilation of emplacement drifts and verify its numerical application in accordance with new procedural requirements as outlined in AP-SIII-10Q, Models (Section 7.0). (2) To satisfy technical issues posed in KTI agreement RDTME 3.14 (Reamer and Williams 2001a). Specifically to demonstrate, with respect to the ANSYS ventilation model, the adequacy of the discretization (Section 6.2.3.1), and the downstream applicability of the model results (i.e. wall heat fractions) to

  4. Modeling Documents with Event Model

    Directory of Open Access Journals (Sweden)

    Longhui Wang

    2015-08-01

    Full Text Available Currently deep learning has made great breakthroughs in visual and speech processing, mainly because it draws lessons from the hierarchical mode that brain deals with images and speech. In the field of NLP, a topic model is one of the important ways for modeling documents. Topic models are built on a generative model that clearly does not match the way humans write. In this paper, we propose Event Model, which is unsupervised and based on the language processing mechanism of neurolinguistics, to model documents. In Event Model, documents are descriptions of concrete or abstract events seen, heard, or sensed by people and words are objects in the events. Event Model has two stages: word learning and dimensionality reduction. Word learning is to learn semantics of words based on deep learning. Dimensionality reduction is the process that representing a document as a low dimensional vector by a linear mode that is completely different from topic models. Event Model achieves state-of-the-art results on document retrieval tasks.

  5. Model Selection for Geostatistical Models

    Energy Technology Data Exchange (ETDEWEB)

    Hoeting, Jennifer A.; Davis, Richard A.; Merton, Andrew A.; Thompson, Sandra E.

    2006-02-01

    We consider the problem of model selection for geospatial data. Spatial correlation is typically ignored in the selection of explanatory variables and this can influence model selection results. For example, the inclusion or exclusion of particular explanatory variables may not be apparent when spatial correlation is ignored. To address this problem, we consider the Akaike Information Criterion (AIC) as applied to a geostatistical model. We offer a heuristic derivation of the AIC in this context and provide simulation results that show that using AIC for a geostatistical model is superior to the often used approach of ignoring spatial correlation in the selection of explanatory variables. These ideas are further demonstrated via a model for lizard abundance. We also employ the principle of minimum description length (MDL) to variable selection for the geostatistical model. The effect of sampling design on the selection of explanatory covariates is also explored.

  6. Didactical modelling

    DEFF Research Database (Denmark)

    Højgaard, Tomas; Hansen, Rune

    2016-01-01

    The purpose of this paper is to introduce Didactical Modelling as a research methodology in mathematics education. We compare the methodology with other approaches and argue that Didactical Modelling has its own specificity. We discuss the methodological “why” and explain why we find it useful to...

  7. Didactical modelling

    OpenAIRE

    Højgaard, Tomas; Hansen, Rune

    2016-01-01

    The purpose of this paper is to introduce Didactical Modelling as a research methodology in mathematics education. We compare the methodology with other approaches and argue that Didactical Modelling has its own specificity. We discuss the methodological “why” and explain why we find it useful to construct this approach in mathematics education research.

  8. Animal models

    DEFF Research Database (Denmark)

    Gøtze, Jens Peter; Krentz, Andrew

    2014-01-01

    In this issue of Cardiovascular Endocrinology, we are proud to present a broad and dedicated spectrum of reviews on animal models in cardiovascular disease. The reviews cover most aspects of animal models in science from basic differences and similarities between small animals and the human...

  9. Martingale Model

    OpenAIRE

    Giandomenico, Rossano

    2006-01-01

    The model determines a stochastic continuous process as continuous limit of a stochastic discrete process so to show that the stochastic continuous process converges to the stochastic discrete process such that we can integrate it. Furthermore, the model determines the expected volatility and the expected mean so to show that the volatility and the mean are increasing function of the time.

  10. Dispersion Modeling.

    Science.gov (United States)

    Budiansky, Stephen

    1980-01-01

    This article discusses the need for more accurate and complete input data and field verification of the various models of air pollutant dispension. Consideration should be given to changing the form of air quality standards based on enhanced dispersion modeling techniques. (Author/RE)

  11. Education models

    NARCIS (Netherlands)

    Poortman, Sybilla; Sloep, Peter

    2006-01-01

    Educational models describes a case study on a complex learning object. Possibilities are investigated for using this learning object, which is based on a particular educational model, outside of its original context. Furthermore, this study provides advice that might lead to an increase in

  12. Battery Modeling

    NARCIS (Netherlands)

    Jongerden, M.R.; Haverkort, Boudewijn R.H.M.

    2008-01-01

    The use of mobile devices is often limited by the capacity of the employed batteries. The battery lifetime determines how long one can use a device. Battery modeling can help to predict, and possibly extend this lifetime. Many different battery models have been developed over the years. However,

  13. Linguistic models and linguistic modeling.

    Science.gov (United States)

    Pedryez, W; Vasilakos, A V

    1999-01-01

    The study is concerned with a linguistic approach to the design of a new category of fuzzy (granular) models. In contrast to numerically driven identification techniques, we concentrate on budding meaningful linguistic labels (granules) in the space of experimental data and forming the ensuing model as a web of associations between such granules. As such models are designed at the level of information granules and generate results in the same granular rather than pure numeric format, we refer to them as linguistic models. Furthermore, as there are no detailed numeric estimation procedures involved in the construction of the linguistic models carried out in this way, their design mode can be viewed as that of a rapid prototyping. The underlying algorithm used in the development of the models utilizes an augmented version of the clustering technique (context-based clustering) that is centered around a notion of linguistic contexts-a collection of fuzzy sets or fuzzy relations defined in the data space (more precisely a space of input variables). The detailed design algorithm is provided and contrasted with the standard modeling approaches commonly encountered in the literature. The usefulness of the linguistic mode of system modeling is discussed and illustrated with the aid of numeric studies including both synthetic data as well as some time series dealing with modeling traffic intensity over a broadband telecommunication network.

  14. OSPREY Model

    Energy Technology Data Exchange (ETDEWEB)

    Veronica J. Rutledge

    2013-01-01

    The absence of industrial scale nuclear fuel reprocessing in the U.S. has precluded the necessary driver for developing the advanced simulation capability now prevalent in so many other countries. Thus, it is essential to model complex series of unit operations to simulate, understand, and predict inherent transient behavior and feedback loops. A capability of accurately simulating the dynamic behavior of advanced fuel cycle separation processes will provide substantial cost savings and many technical benefits. The specific fuel cycle separation process discussed in this report is the off-gas treatment system. The off-gas separation consists of a series of scrubbers and adsorption beds to capture constituents of interest. Dynamic models are being developed to simulate each unit operation involved so each unit operation can be used as a stand-alone model and in series with multiple others. Currently, an adsorption model has been developed within Multi-physics Object Oriented Simulation Environment (MOOSE) developed at the Idaho National Laboratory (INL). Off-gas Separation and REcoverY (OSPREY) models the adsorption of off-gas constituents for dispersed plug flow in a packed bed under non-isothermal and non-isobaric conditions. Inputs to the model include gas, sorbent, and column properties, equilibrium and kinetic data, and inlet conditions. The simulation outputs component concentrations along the column length as a function of time from which breakthrough data is obtained. The breakthrough data can be used to determine bed capacity, which in turn can be used to size columns. It also outputs temperature along the column length as a function of time and pressure drop along the column length. Experimental data and parameters were input into the adsorption model to develop models specific for krypton adsorption. The same can be done for iodine, xenon, and tritium. The model will be validated with experimental breakthrough curves. Customers will be given access to

  15. Model hydrographs

    Science.gov (United States)

    Mitchell, W.D.

    1972-01-01

    Model hydrographs are composed of pairs of dimensionless ratios, arrayed in tabular form, which, when modified by the appropriate values of rainfall exceed and by the time and areal characteristics of the drainage basin, satisfactorily represent the flood hydrograph for the basin. Model bydrographs are developed from a dimensionless translation hydrograph, having a time base of T hours and appropriately modified for storm duration by routing through reservoir storage, S=kOx. Models fall into two distinct classes: (1) those for which the value of x is unity and which have all the characteristics of true unit hydrographs and (2) those for which the value of x is other than unity and to which the unit-hydrograph principles of proportionality and superposition do not apply. Twenty-six families of linear models and eight families of nonlinear models in tabular form from the principal subject of this report. Supplemental discussions describe the development of the models and illustrate their application. Other sections of the report, supplemental to the tables, describe methods of determining the hydrograph characteristics, T, k, and x, both from observed hydrograph and from the physical characteristics of the drainage basin. Five illustrative examples of use show that the models, when properly converted to incorporate actual rainfall excess and the time and areal characteristics of the drainage basins, do indeed satisfactorily represent the observed flood hydrographs for the basins.

  16. Stereometric Modelling

    Science.gov (United States)

    Grimaldi, P.

    2012-07-01

    These mandatory guidelines are provided for preparation of papers accepted for publication in the series of Volumes of The The stereometric modelling means modelling achieved with : - the use of a pair of virtual cameras, with parallel axes and positioned at a mutual distance average of 1/10 of the distance camera-object (in practice the realization and use of a stereometric camera in the modeling program); - the shot visualization in two distinct windows - the stereoscopic viewing of the shot while modelling. Since the definition of "3D vision" is inaccurately referred to as the simple perspective of an object, it is required to add the word stereo so that "3D stereo vision " shall stand for "three-dimensional view" and ,therefore, measure the width, height and depth of the surveyed image. Thanks to the development of a stereo metric model , either real or virtual, through the "materialization", either real or virtual, of the optical-stereo metric model made visible with a stereoscope. It is feasible a continuous on line updating of the cultural heritage with the help of photogrammetry and stereometric modelling. The catalogue of the Architectonic Photogrammetry Laboratory of Politecnico di Bari is available on line at: http://rappresentazione.stereofot.it:591/StereoFot/FMPro?-db=StereoFot.fp5&-lay=Scheda&-format=cerca.htm&-view

  17. Modeling complexes of modeled proteins.

    Science.gov (United States)

    Anishchenko, Ivan; Kundrotas, Petras J; Vakser, Ilya A

    2017-03-01

    Structural characterization of proteins is essential for understanding life processes at the molecular level. However, only a fraction of known proteins have experimentally determined structures. This fraction is even smaller for protein-protein complexes. Thus, structural modeling of protein-protein interactions (docking) primarily has to rely on modeled structures of the individual proteins, which typically are less accurate than the experimentally determined ones. Such "double" modeling is the Grand Challenge of structural reconstruction of the interactome. Yet it remains so far largely untested in a systematic way. We present a comprehensive validation of template-based and free docking on a set of 165 complexes, where each protein model has six levels of structural accuracy, from 1 to 6 Å C(α) RMSD. Many template-based docking predictions fall into acceptable quality category, according to the CAPRI criteria, even for highly inaccurate proteins (5-6 Å RMSD), although the number of such models (and, consequently, the docking success rate) drops significantly for models with RMSD > 4 Å. The results show that the existing docking methodologies can be successfully applied to protein models with a broad range of structural accuracy, and the template-based docking is much less sensitive to inaccuracies of protein models than the free docking. Proteins 2017; 85:470-478. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  18. A Model for Math Modeling

    Science.gov (United States)

    Lin, Tony; Erfan, Sasan

    2016-01-01

    Mathematical modeling is an open-ended research subject where no definite answers exist for any problem. Math modeling enables thinking outside the box to connect different fields of studies together including statistics, algebra, calculus, matrices, programming and scientific writing. As an integral part of society, it is the foundation for many…

  19. Modelling survival

    DEFF Research Database (Denmark)

    Ashauer, Roman; Albert, Carlo; Augustine, Starrlight

    2016-01-01

    The General Unified Threshold model for Survival (GUTS) integrates previously published toxicokinetic-toxicodynamic models and estimates survival with explicitly defined assumptions. Importantly, GUTS accounts for time-variable exposure to the stressor. We performed three studies to test...... the ability of GUTS to predict survival of aquatic organisms across different pesticide exposure patterns, time scales and species. Firstly, using synthetic data, we identified experimental data requirements which allow for the estimation of all parameters of the GUTS proper model. Secondly, we assessed how...

  20. José Gorostiza y T. S. Eliot : un acercamiento a las poéticas del poema extenso moderno en Muerte sin fin y Four quartets /

    OpenAIRE

    Bothe, Pauly Ellen sustentante.

    2009-01-01

     tesis que para obtener el grado de Doctor en Letras, presenta Pauly Ellen Bothe ; asesor Jorge Alcázar Bravo. 206 páginas : ilustraciones. Doctorado en Letras UNAM, Facultad de Filosofía y Letras, 2009

  1. Adinkras from ordered quartets of BC4 Coxeter group elements and regarding 1,358,954,496 matrix elements of the Gadget

    Science.gov (United States)

    Gates, S. James; Guyton, Forrest; Harmalkar, Siddhartha; Kessler, David S.; Korotkikh, Vadim; Meszaros, Victor A.

    2017-06-01

    We examine values of the Adinkra Holoraumy-induced Gadget representation space metric over all possible four-color, four-open node, and four-closed node adinkras. Of the 1,358,954,496 gadget matrix elements, only 226,492,416 are non-vanishing and take on one of three values: -1/3, 1/3, or 1 and thus a subspace isomorphic to a description of a body-centered tetrahedral molecule emerges.

  2. Bruce's Magnificent Quartet: Inquiry, Community, Technology and Literacy--Implications for Renewing Qualitative Research in the Twenty-First Century

    Science.gov (United States)

    Davidson, Judith

    2014-01-01

    Bruce and Bishop's community informatics work brings forward four critical concepts: inquiry, community, technology, and literacy. These four terms serve as the basis for a discussion of qualitative research in the twenty-first century--what is lacking and what is needed. The author suggests that to resolve the tensions or challenges…

  3. The DUNDRUM Quartet: validation of structured professional judgement instruments DUNDRUM-3 assessment of programme completion and DUNDRUM-4 assessment of recovery in forensic mental health services.

    LENUS (Irish Health Repository)

    O'Dwyer, Sarah

    2011-07-03

    Abstract Background Moving a forensic mental health patient from one level of therapeutic security to a lower level or to the community is influenced by more than risk assessment and risk management. We set out to construct and validate structured professional judgement instruments for consistency and transparency in decision making Methods Two instruments were developed, the seven-item DUNDRUM-3 programme completion instrument and the six item DUNDRUM-4 recovery instrument. These were assessed for all 95 forensic patients at Ireland\\'s only forensic mental health hospital. Results The two instruments had good internal consistency (Cronbach\\'s alpha 0.911 and 0.887). Scores distinguished those allowed no leave or accompanied leave from those with unaccompanied leave (ANOVA F = 38.1 and 50.3 respectively, p < 0.001). Scores also distinguished those in acute\\/high security units from those in medium or in low secure\\/pre-discharge units. Each individual item distinguished these levels of need significantly. The DUNDRUM-3 and DUNDRUM-4 correlated moderately with measures of dynamic risk and with the CANFOR staff rated unmet need (Spearman r = 0.5, p < 0.001). Conclusions The DUNDRUM-3 programme completion items distinguished significantly between levels of therapeutic security while the DUNDRUM-4 recovery items consistently distinguished those given unaccompanied leave outside the hospital and those in the lowest levels of therapeutic security. This data forms the basis for a prospective study of outcomes now underway.

  4. The DUNDRUM Quartet: validation of structured professional judgement instruments DUNDRUM-3 assessment of programme completion and DUNDRUM-4 assessment of recovery in forensic mental health services

    Directory of Open Access Journals (Sweden)

    McDonnell Kim

    2011-07-01

    Full Text Available Abstract Background Moving a forensic mental health patient from one level of therapeutic security to a lower level or to the community is influenced by more than risk assessment and risk management. We set out to construct and validate structured professional judgement instruments for consistency and transparency in decision making Methods Two instruments were developed, the seven-item DUNDRUM-3 programme completion instrument and the six item DUNDRUM-4 recovery instrument. These were assessed for all 95 forensic patients at Ireland's only forensic mental health hospital. Results The two instruments had good internal consistency (Cronbach's alpha 0.911 and 0.887. Scores distinguished those allowed no leave or accompanied leave from those with unaccompanied leave (ANOVA F = 38.1 and 50.3 respectively, p Conclusions The DUNDRUM-3 programme completion items distinguished significantly between levels of therapeutic security while the DUNDRUM-4 recovery items consistently distinguished those given unaccompanied leave outside the hospital and those in the lowest levels of therapeutic security. This data forms the basis for a prospective study of outcomes now underway.

  5. Bruce's Magnificent Quartet: Inquiry, Community, Technology and Literacy--Implications for Renewing Qualitative Research in the Twenty-First Century

    Science.gov (United States)

    Davidson, Judith

    2014-01-01

    Bruce and Bishop's community informatics work brings forward four critical concepts: inquiry, community, technology, and literacy. These four terms serve as the basis for a discussion of qualitative research in the twenty-first century--what is lacking and what is needed. The author suggests that to resolve the tensions or challenges…

  6. Evidence for a breakdown of the Isobaric Multiplet Mass Equation: A study of the A=35, T=3/2 isospin quartet

    CERN Document Server

    Yazidjian, C; Beck, D; Blaum, K; George, S; Guénaut, C; Herfurth, F; Herlert, A; Kellerbauer, A G; Kluge, H J; Lunney, D; Schweikhard, L

    2007-01-01

    Mass measurements on radionuclides along the potassium isotope chain have been performed with the ISOLTRAP Penning trap mass spectrometer. For 35K T1/2=178ms) to 46K (T1/2=105s) relative mass uncertainties of 2x10-8 and better have been achieved. The accurate mass determination of 35K (dm=0.54keV) has been exploited to test the Isobaric Multiplet Mass Equation (IMME) for the A=35, T=3/2 isospinquartet. The experimental results indicate a deviation from the generally adopted quadratic form.

  7. Whole-exome re-sequencing in a family quartet identifies POP1 mutations as the cause of a novel skeletal dysplasia.

    Directory of Open Access Journals (Sweden)

    Evgeny A Glazov

    2011-03-01

    Full Text Available Recent advances in DNA sequencing have enabled mapping of genes for monogenic traits in families with small pedigrees and even in unrelated cases. We report the identification of disease-causing mutations in a rare, severe, skeletal dysplasia, studying a family of two healthy unrelated parents and two affected children using whole-exome sequencing. The two affected daughters have clinical and radiographic features suggestive of anauxetic dysplasia (OMIM 607095, a rare form of dwarfism caused by mutations of RMRP. However, mutations of RMRP were excluded in this family by direct sequencing. Our studies identified two novel compound heterozygous loss-of-function mutations in POP1, which encodes a core component of the RNase mitochondrial RNA processing (RNase MRP complex that directly interacts with the RMRP RNA domains that are affected in anauxetic dysplasia. We demonstrate that these mutations impair the integrity and activity of this complex and that they impair cell proliferation, providing likely molecular and cellular mechanisms by which POP1 mutations cause this severe skeletal dysplasia.

  8. The elegant velvet glove: A textual and visual reading of the gothicised female form in Lawrence Durrell’s 'The Alexandria quartet'

    NARCIS (Netherlands)

    A.D. Kreuiter

    2014-01-01

    My thesis analyses the gothicisation of the female form in ‘The Alexandria quartet’ written by the English novelist Lawrence Durrell. In this study I show how Durrell's concern with the themes of space-time-memory, ambiguity, multiple perspectives, metaphoric imagery, buried or not-so-buried acts of

  9. Whole-exome re-sequencing in a family quartet identifies POP1 mutations as the cause of a novel skeletal dysplasia.

    Directory of Open Access Journals (Sweden)

    Evgeny A Glazov

    2011-03-01

    Full Text Available Recent advances in DNA sequencing have enabled mapping of genes for monogenic traits in families with small pedigrees and even in unrelated cases. We report the identification of disease-causing mutations in a rare, severe, skeletal dysplasia, studying a family of two healthy unrelated parents and two affected children using whole-exome sequencing. The two affected daughters have clinical and radiographic features suggestive of anauxetic dysplasia (OMIM 607095, a rare form of dwarfism caused by mutations of RMRP. However, mutations of RMRP were excluded in this family by direct sequencing. Our studies identified two novel compound heterozygous loss-of-function mutations in POP1, which encodes a core component of the RNase mitochondrial RNA processing (RNase MRP complex that directly interacts with the RMRP RNA domains that are affected in anauxetic dysplasia. We demonstrate that these mutations impair the integrity and activity of this complex and that they impair cell proliferation, providing likely molecular and cellular mechanisms by which POP1 mutations cause this severe skeletal dysplasia.

  10. The elegant velvet glove: A textual and visual reading of the gothicised female form in Lawrence Durrell’s 'The Alexandria quartet'

    NARCIS (Netherlands)

    Kreuiter, A.D.

    2014-01-01

    My thesis analyses the gothicisation of the female form in ‘The Alexandria quartet’ written by the English novelist Lawrence Durrell. In this study I show how Durrell's concern with the themes of space-time-memory, ambiguity, multiple perspectives, metaphoric imagery, buried or not-so-buried acts of

  11. Modelling Constructs

    DEFF Research Database (Denmark)

    Kindler, Ekkart

    2009-01-01

    There are many different notations and formalisms for modelling business processes and workflows. These notations and formalisms have been introduced with different purposes and objectives. Later, influenced by other notations, comparisons with other tools, or by standardization efforts, these no...

  12. Linear Models

    CERN Document Server

    Searle, Shayle R

    2012-01-01

    This 1971 classic on linear models is once again available--as a Wiley Classics Library Edition. It features material that can be understood by any statistician who understands matrix algebra and basic statistical methods.

  13. Modeling Arcs

    CERN Document Server

    Insepov, Zeke; Veitzer, Seth; Mahalingam, Sudhakar

    2011-01-01

    Although vacuum arcs were first identified over 110 years ago, they are not yet well understood. We have since developed a model of breakdown and gradient limits that tries to explain, in a self-consistent way: arc triggering, plasma initiation, plasma evolution, surface damage and gra- dient limits. We use simple PIC codes for modeling plasmas, molecular dynamics for modeling surface breakdown, and surface damage, and mesoscale surface thermodynamics and finite element electrostatic codes for to evaluate surface properties. Since any given experiment seems to have more variables than data points, we have tried to consider a wide variety of arcing (rf structures, e beam welding, laser ablation, etc.) to help constrain the problem, and concentrate on common mechanisms. While the mechanisms can be comparatively simple, modeling can be challenging.

  14. Paleoclimate Modeling

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Computer simulations of past climate. Variables provided as model output are described by parameter keyword. In some cases the parameter keywords are a subset of all...

  15. Anchor Modeling

    Science.gov (United States)

    Regardt, Olle; Rönnbäck, Lars; Bergholtz, Maria; Johannesson, Paul; Wohed, Petia

    Maintaining and evolving data warehouses is a complex, error prone, and time consuming activity. The main reason for this state of affairs is that the environment of a data warehouse is in constant change, while the warehouse itself needs to provide a stable and consistent interface to information spanning extended periods of time. In this paper, we propose a modeling technique for data warehousing, called anchor modeling, that offers non-destructive extensibility mechanisms, thereby enabling robust and flexible management of changes in source systems. A key benefit of anchor modeling is that changes in a data warehouse environment only require extensions, not modifications, to the data warehouse. This ensures that existing data warehouse applications will remain unaffected by the evolution of the data warehouse, i.e. existing views and functions will not have to be modified as a result of changes in the warehouse model.

  16. Model theory

    CERN Document Server

    Hodges, Wilfrid

    1993-01-01

    An up-to-date and integrated introduction to model theory, designed to be used for graduate courses (for students who are familiar with first-order logic), and as a reference for more experienced logicians and mathematicians.

  17. Accelerated life models modeling and statistical analysis

    CERN Document Server

    Bagdonavicius, Vilijandas

    2001-01-01

    Failure Time DistributionsIntroductionParametric Classes of Failure Time DistributionsAccelerated Life ModelsIntroductionGeneralized Sedyakin's ModelAccelerated Failure Time ModelProportional Hazards ModelGeneralized Proportional Hazards ModelsGeneralized Additive and Additive-Multiplicative Hazards ModelsChanging Shape and Scale ModelsGeneralizationsModels Including Switch-Up and Cycling EffectsHeredity HypothesisSummaryAccelerated Degradation ModelsIntroductionDegradation ModelsModeling the Influence of Explanatory Varia

  18. Do stroke models model stroke?

    Directory of Open Access Journals (Sweden)

    Philipp Mergenthaler

    2012-11-01

    Full Text Available Stroke is one of the leading causes of death worldwide and the biggest reason for long-term disability. Basic research has formed the modern understanding of stroke pathophysiology, and has revealed important molecular, cellular and systemic mechanisms. However, despite decades of research, most translational stroke trials that aim to introduce basic research findings into clinical treatment strategies – most notably in the field of neuroprotection – have failed. Among other obstacles, poor methodological and statistical standards, negative publication bias, and incomplete preclinical testing have been proposed as ‘translational roadblocks’. In this article, we introduce the models commonly used in preclinical stroke research, discuss some of the causes of failed translational success and review potential remedies. We further introduce the concept of modeling ‘care’ of stroke patients, because current preclinical research models the disorder but does not model care or state-of-the-art clinical testing. Stringent statistical methods and controlled preclinical trials have been suggested to counteract weaknesses in preclinical research. We conclude that preclinical stroke research requires (1 appropriate modeling of the disorder, (2 appropriate modeling of the care of stroke patients and (3 an approach to preclinical testing that is similar to clinical testing, including Phase 3 randomized controlled preclinical trials as necessary additional steps before new therapies enter clinical testing.

  19. Persistent Modelling

    DEFF Research Database (Denmark)

    2012-01-01

    The relationship between representation and the represented is examined here through the notion of persistent modelling. This notion is not novel to the activity of architectural design if it is considered as describing a continued active and iterative engagement with design concerns – an evident...... characteristic of architectural practice. But the persistence in persistent modelling can also be understood to apply in other ways, reflecting and anticipating extended roles for representation. This book identifies three principle areas in which these extensions are becoming apparent within contemporary....... It also provides critical insight into the use of contemporary modelling tools and methods, together with an examination of the implications their use has within the territories of architectural design, realisation and experience....

  20. Mathematical modeling

    CERN Document Server

    Eck, Christof; Knabner, Peter

    2017-01-01

    Mathematical models are the decisive tool to explain and predict phenomena in the natural and engineering sciences. With this book readers will learn to derive mathematical models which help to understand real world phenomena. At the same time a wealth of important examples for the abstract concepts treated in the curriculum of mathematics degrees are given. An essential feature of this book is that mathematical structures are used as an ordering principle and not the fields of application. Methods from linear algebra, analysis and the theory of ordinary and partial differential equations are thoroughly introduced and applied in the modeling process. Examples of applications in the fields electrical networks, chemical reaction dynamics, population dynamics, fluid dynamics, elasticity theory and crystal growth are treated comprehensively.

  1. Inflatable Models

    Institute of Scientific and Technical Information of China (English)

    Ling Li; Vasily Volkov

    2006-01-01

    A physically-based model is presented for the simulation of a new type of deformable objects-inflatable objects, such as shaped balloons, which consist of pressurized air enclosed by an elastic surface. These objects have properties inherent in both 3D and 2D elastic bodies, as they demonstrate the behaviour of 3D shapes using 2D formulations. As there is no internal structure in them, their behaviour is substantially different from the behaviour of deformable solid objects. We use one of the few available models for deformable surfaces, and enhance it to include the forces of internal and external pressure. These pressure forces may also incorporate buoyancy forces, to allow objects filled with a low density gas to float in denser media. The obtained models demonstrate rich dynamic behaviour, such as bouncing, floating, deflation and inflation.

  2. Lens Model

    DEFF Research Database (Denmark)

    Nash, Ulrik William

    2014-01-01

    Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory of probabil......Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory...... of probabilistic functionalism, and concerns the environment and the mind, and adaptation by the latter to the former. This entry is about the lens model, and probabilistic functionalism more broadly. Focus will mostly be on firms and their employees, but, to fully appreciate the scope, we have to keep in mind...

  3. Lens Model

    DEFF Research Database (Denmark)

    Nash, Ulrik William

    2014-01-01

    Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory of probabil......Firms consist of people who make decisions to achieve goals. How do these people develop the expectations which underpin the choices they make? The lens model provides one answer to this question. It was developed by cognitive psychologist Egon Brunswik (1952) to illustrate his theory...

  4. Molecular modeling

    Directory of Open Access Journals (Sweden)

    Aarti Sharma

    2009-01-01

    Full Text Available The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important tool. In the past, drugs were simply screened for effectiveness. The recent advances in computing power and the exponential growth of the knowledge of protein structures have made it possible for organic compounds to be tailored to decrease the harmful side effects and increase the potency. This article provides a detailed description of the techniques employed in molecular modeling. Molecular modeling is a rapidly developing discipline, and has been supported by the dramatic improvements in computer hardware and software in recent years.

  5. Smashnova Model

    CERN Document Server

    Sivaram, C

    2007-01-01

    An alternate model for gamma ray bursts is suggested. For a white dwarf (WD) and neutron star (NS) very close binary system, the WD (close to Mch) can detonate due to tidal heating, leading to a SN. Material falling on to the NS at relativistic velocities can cause its collapse to a magnetar or quark star or black hole leading to a GRB. As the material smashes on to the NS, it is dubbed the Smashnova model. Here the SN is followed by a GRB. NS impacting a RG (or RSG) (like in Thorne-Zytkow objects) can also cause a SN outburst followed by a GRB. Other variations are explored.

  6. Modelling language

    CERN Document Server

    Cardey, Sylviane

    2013-01-01

    In response to the need for reliable results from natural language processing, this book presents an original way of decomposing a language(s) in a microscopic manner by means of intra/inter‑language norms and divergences, going progressively from languages as systems to the linguistic, mathematical and computational models, which being based on a constructive approach are inherently traceable. Languages are described with their elements aggregating or repelling each other to form viable interrelated micro‑systems. The abstract model, which contrary to the current state of the art works in int

  7. Isospin Symmetry Violation in sd-Shell Nuclei

    Directory of Open Access Journals (Sweden)

    Lam Yi Hua

    2014-03-01

    Full Text Available We construct a new set of isospin-nonconserving (INC shell-model Hamiltonians and apply it (i to study the isobaric-mass multiplet equation (IMME beyond a quadratic form in the A = 35, 3/2+ quartet, (ii to compute the isospin mixing corrections to superallowed Fermi branch of 1+ → 1+ β decay of 32Cl, and (iii to obtain the isospin-forbidden branching ratios of β-delayed proton emission from 25Si.

  8. Building Models and Building Modelling

    DEFF Research Database (Denmark)

    Jørgensen, Kaj Asbjørn; Skauge, Jørn

    I rapportens indledende kapitel beskrives de primære begreber vedrørende bygningsmodeller og nogle fundamentale forhold vedrørende computerbaseret modulering bliver opstillet. Desuden bliver forskellen mellem tegneprogrammer og bygnings­model­lerings­programmer beskrevet. Vigtige aspekter om......­lering og bygningsmodeller. Det bliver understreget at modellering bør udføres på flere abstraktions­niveauer og i to dimensioner i den såkaldte modelleringsmatrix. Ud fra dette identificeres de primære faser af bygningsmodel­lering. Dernæst beskrives de basale karakteristika for bygningsmodeller. Heri...... inkluderes en præcisering af begreberne objektorienteret software og objektorienteret modeller. Det bliver fremhævet at begrebet objektbaseret modellering giver en tilstrækkelig og bedre forståelse. Endelig beskrives forestillingen om den ideale bygningsmodel som værende én samlet model, der anvendes gennem...

  9. Zeebrugge Model

    DEFF Research Database (Denmark)

    Jensen, Morten S.; Frigaard, Peter

    In the following, results from model tests with Zeebrugge breakwater are presented. The objective with these tests is partly to investigate the influence on wave run-up due to a changing waterlevel during a storm. Finally, the influence on wave run-up due to an introduced longshore current...

  10. Why Model?

    Directory of Open Access Journals (Sweden)

    Olaf eWolkenhauer

    2014-01-01

    Full Text Available Next generation sequencing technologies are bringing about a renaissance of mining approaches. A comprehensive picture of the genetic landscape of an individual patient will be useful, for example, to identify groups of patients that do or do not respond to certain therapies. The high expectations may however not be satisfied if the number of patient groups with similar characteristics is going to be very large. I therefore doubt that mining sequence data will give us an understanding of why and when therapies work. For understanding the mechanisms underlying diseases, an alternative approach is to model small networks in quantitative mechanistic detail, to elucidate the role of gene and proteins in dynamically changing the functioning of cells. Here an obvious critique is that these models consider too few components, compared to what might be relevant for any particular cell function. I show here that mining approaches and dynamical systems theory are two ends of a spectrum of methodologies to choose from. Drawing upon personal experience in numerous interdisciplinary collaborations, I provide guidance on how to model by discussing the question Why model?

  11. Why model?

    Science.gov (United States)

    Wolkenhauer, Olaf

    2014-01-01

    Next generation sequencing technologies are bringing about a renaissance of mining approaches. A comprehensive picture of the genetic landscape of an individual patient will be useful, for example, to identify groups of patients that do or do not respond to certain therapies. The high expectations may however not be satisfied if the number of patient groups with similar characteristics is going to be very large. I therefore doubt that mining sequence data will give us an understanding of why and when therapies work. For understanding the mechanisms underlying diseases, an alternative approach is to model small networks in quantitative mechanistic detail, to elucidate the role of gene and proteins in dynamically changing the functioning of cells. Here an obvious critique is that these models consider too few components, compared to what might be relevant for any particular cell function. I show here that mining approaches and dynamical systems theory are two ends of a spectrum of methodologies to choose from. Drawing upon personal experience in numerous interdisciplinary collaborations, I provide guidance on how to model by discussing the question "Why model?"

  12. Model CAPM

    OpenAIRE

    Burianová, Eva

    2008-01-01

    Cílem první části této bakalářské práce je - pomocí analýzy výchozích textů - teoretické shrnutí ekonomických modelů a teorií, na kterých model CAPM stojí: Markowitzův model teorie portfolia (analýza maximalizace očekávaného užitku a na něm založený model výběru optimálního portfolia), Tobina (rozšíření Markowitzova modelu ? rozdělení výběru optimálního portfolia do dvou fází; nejprve určení optimální kombinace rizikových instrumentů a následná alokace dostupného kapitálu mezi tuto optimální ...

  13. Transport modeling

    Institute of Scientific and Technical Information of China (English)

    R.E. Waltz

    2007-01-01

    @@ There has been remarkable progress during the past decade in understanding and modeling turbulent transport in tokamaks. With some exceptions the progress is derived from the huge increases in computational power and the ability to simulate tokamak turbulence with ever more fundamental and physically realistic dynamical equations, e.g.

  14. Painting models

    Science.gov (United States)

    Baart, F.; Donchyts, G.; van Dam, A.; Plieger, M.

    2015-12-01

    The emergence of interactive art has blurred the line between electronic, computer graphics and art. Here we apply this art form to numerical models. Here we show how the transformation of a numerical model into an interactive painting can both provide insights and solve real world problems. The cases that are used as an example include forensic reconstructions, dredging optimization, barrier design. The system can be fed using any source of time varying vector fields, such as hydrodynamic models. The cases used here, the Indian Ocean (HYCOM), the Wadden Sea (Delft3D Curvilinear), San Francisco Bay (3Di subgrid and Delft3D Flexible Mesh), show that the method used is suitable for different time and spatial scales. High resolution numerical models become interactive paintings by exchanging their velocity fields with a high resolution (>=1M cells) image based flow visualization that runs in a html5 compatible web browser. The image based flow visualization combines three images into a new image: the current image, a drawing, and a uv + mask field. The advection scheme that computes the resultant image is executed in the graphics card using WebGL, allowing for 1M grid cells at 60Hz performance on mediocre graphic cards. The software is provided as open source software. By using different sources for a drawing one can gain insight into several aspects of the velocity fields. These aspects include not only the commonly represented magnitude and direction, but also divergence, topology and turbulence .

  15. Modeling Muscles

    Science.gov (United States)

    Goodwyn, Lauren; Salm, Sarah

    2007-01-01

    Teaching the anatomy of the muscle system to high school students can be challenging. Students often learn about muscle anatomy by memorizing information from textbooks or by observing plastic, inflexible models. Although these mediums help students learn about muscle placement, the mediums do not facilitate understanding regarding integration of…

  16. Entrepreneurship Models.

    Science.gov (United States)

    Finger Lakes Regional Education Center for Economic Development, Mount Morris, NY.

    This guide describes seven model programs that were developed by the Finger Lakes Regional Center for Economic Development (New York) to meet the training needs of female and minority entrepreneurs to help their businesses survive and grow and to assist disabled and dislocated workers and youth in beginning small businesses. The first three models…

  17. Quality modelling

    NARCIS (Netherlands)

    Tijskens, L.M.M.

    2003-01-01

    For modelling product behaviour, with respect to quality for users and consumers, its essential to have at least a fundamental notion what quality really is, and which product properties determine the quality assigned by the consumer to a product. In other words: what is allowed and what is to be

  18. Criticality Model

    Energy Technology Data Exchange (ETDEWEB)

    A. Alsaed

    2004-09-14

    The ''Disposal Criticality Analysis Methodology Topical Report'' (YMP 2003) presents the methodology for evaluating potential criticality situations in the monitored geologic repository. As stated in the referenced Topical Report, the detailed methodology for performing the disposal criticality analyses will be documented in model reports. Many of the models developed in support of the Topical Report differ from the definition of models as given in the Office of Civilian Radioactive Waste Management procedure AP-SIII.10Q, ''Models'', in that they are procedural, rather than mathematical. These model reports document the detailed methodology necessary to implement the approach presented in the Disposal Criticality Analysis Methodology Topical Report and provide calculations utilizing the methodology. Thus, the governing procedure for this type of report is AP-3.12Q, ''Design Calculations and Analyses''. The ''Criticality Model'' is of this latter type, providing a process evaluating the criticality potential of in-package and external configurations. The purpose of this analysis is to layout the process for calculating the criticality potential for various in-package and external configurations and to calculate lower-bound tolerance limit (LBTL) values and determine range of applicability (ROA) parameters. The LBTL calculations and the ROA determinations are performed using selected benchmark experiments that are applicable to various waste forms and various in-package and external configurations. The waste forms considered in this calculation are pressurized water reactor (PWR), boiling water reactor (BWR), Fast Flux Test Facility (FFTF), Training Research Isotope General Atomic (TRIGA), Enrico Fermi, Shippingport pressurized water reactor, Shippingport light water breeder reactor (LWBR), N-Reactor, Melt and Dilute, and Fort Saint Vrain Reactor spent nuclear fuel (SNF). The scope of

  19. Information Model for Product Modeling

    Institute of Scientific and Technical Information of China (English)

    焦国方; 刘慎权

    1992-01-01

    The Key problems in product modeling for integrated CAD ∥CAM systems are the information structures and representations of products.They are taking more and more important roles in engineering applications.With the investigation on engineering product information and from the viewpoint of industrial process,in this paper,the information models are proposed and the definitions of the framework of product information are given.And then,the integration and the consistence of product information are discussed by introucing the entity and its instance.As a summary,the information structures described in this paper have many advantage and natures helpful in engineering design.

  20. Building Models and Building Modelling

    DEFF Research Database (Denmark)

    Jørgensen, Kaj; Skauge, Jørn

    2008-01-01

    I rapportens indledende kapitel beskrives de primære begreber vedrørende bygningsmodeller og nogle fundamentale forhold vedrørende computerbaseret modulering bliver opstillet. Desuden bliver forskellen mellem tegneprogrammer og bygnings­model­lerings­programmer beskrevet. Vigtige aspekter om comp...

  1. Molecular Modelling

    Directory of Open Access Journals (Sweden)

    Aarti Sharma

    2009-12-01

    Full Text Available

    The use of computational chemistry in the development of novel pharmaceuticals is becoming an increasingly important
    tool. In the past, drugs were simply screened for effectiveness. The recent advances in computing power and
    the exponential growth of the knowledge of protein structures have made it possible for organic compounds to tailored to
    decrease harmful side effects and increase the potency. This article provides a detailed description of the techniques
    employed in molecular modeling. Molecular modelling is a rapidly developing discipline, and has been supported from
    the dramatic improvements in computer hardware and software in recent years.

  2. Cheating models

    DEFF Research Database (Denmark)

    Arnoldi, Jakob

    The article discusses the use of algorithmic models for so-called High Frequency Trading (HFT) in finance. HFT is controversial yet widespread in modern financial markets. It is a form of automated trading technology which critics among other things claim can lead to market manipulation. Drawing...... on two cases, this article shows that manipulation more likely happens in the reverse way, meaning that human traders attempt to make algorithms ‘make mistakes’ or ‘mislead’ algos. Thus, it is algorithmic models, not humans, that are manipulated. Such manipulation poses challenges for security exchanges....... The article analyses these challenges and argues that we witness a new post-social form of human-technology interaction that will lead to a reconfiguration of professional codes for financial trading....

  3. Acyclic models

    CERN Document Server

    Barr, Michael

    2002-01-01

    Acyclic models is a method heavily used to analyze and compare various homology and cohomology theories appearing in topology and algebra. This book is the first attempt to put together in a concise form this important technique and to include all the necessary background. It presents a brief introduction to category theory and homological algebra. The author then gives the background of the theory of differential modules and chain complexes over an abelian category to state the main acyclic models theorem, generalizing and systemizing the earlier material. This is then applied to various cohomology theories in algebra and topology. The volume could be used as a text for a course that combines homological algebra and algebraic topology. Required background includes a standard course in abstract algebra and some knowledge of topology. The volume contains many exercises. It is also suitable as a reference work for researchers.

  4. Nuclear Models

    Science.gov (United States)

    Fossión, Rubén

    2010-09-01

    The atomic nucleus is a typical example of a many-body problem. On the one hand, the number of nucleons (protons and neutrons) that constitute the nucleus is too large to allow for exact calculations. On the other hand, the number of constituent particles is too small for the individual nuclear excitation states to be explained by statistical methods. Another problem, particular for the atomic nucleus, is that the nucleon-nucleon (n-n) interaction is not one of the fundamental forces of Nature, and is hard to put in a single closed equation. The nucleon-nucleon interaction also behaves differently between two free nucleons (bare interaction) and between two nucleons in the nuclear medium (dressed interaction). Because of the above reasons, specific nuclear many-body models have been devised of which each one sheds light on some selected aspects of nuclear structure. Only combining the viewpoints of different models, a global insight of the atomic nucleus can be gained. In this chapter, we revise the the Nuclear Shell Model as an example of the microscopic approach, and the Collective Model as an example of the geometric approach. Finally, we study the statistical properties of nuclear spectra, basing on symmetry principles, to find out whether there is quantum chaos in the atomic nucleus. All three major approaches have been rewarded with the Nobel Prize of Physics. In the text, we will stress how each approach introduces its own series of approximations to reduce the prohibitingly large number of degrees of freedom of the full many-body problem to a smaller manageable number of effective degrees of freedom.

  5. Modelling Behaviour

    DEFF Research Database (Denmark)

    2015-01-01

    This book reflects and expands on the current trend in the building industry to understand, simulate and ultimately design buildings by taking into consideration the interlinked elements and forces that act on them. This approach overcomes the traditional, exclusive focus on building tasks, while....... The chapter authors were invited speakers at the 5th Symposium "Modelling Behaviour", which took place at the CITA in Copenhagen in September 2015....

  6. Modeling Minds

    DEFF Research Database (Denmark)

    Michael, John

    others' minds. Then (2), in order to bring to light some possible justifications, as well as hazards and criticisms of the methodology of looking time tests, I will take a closer look at the concept of folk psychology and will focus on the idea that folk psychology involves using oneself as a model...... of other people in order to predict and understand their behavior. Finally (3), I will discuss the historical location and significance of the emergence of looking time tests...

  7. Modeling biomembranes.

    Energy Technology Data Exchange (ETDEWEB)

    Plimpton, Steven James; Heffernan, Julieanne; Sasaki, Darryl Yoshio; Frischknecht, Amalie Lucile; Stevens, Mark Jackson; Frink, Laura J. Douglas

    2005-11-01

    Understanding the properties and behavior of biomembranes is fundamental to many biological processes and technologies. Microdomains in biomembranes or ''lipid rafts'' are now known to be an integral part of cell signaling, vesicle formation, fusion processes, protein trafficking, and viral and toxin infection processes. Understanding how microdomains form, how they depend on membrane constituents, and how they act not only has biological implications, but also will impact Sandia's effort in development of membranes that structurally adapt to their environment in a controlled manner. To provide such understanding, we created physically-based models of biomembranes. Molecular dynamics (MD) simulations and classical density functional theory (DFT) calculations using these models were applied to phenomena such as microdomain formation, membrane fusion, pattern formation, and protein insertion. Because lipid dynamics and self-organization in membranes occur on length and time scales beyond atomistic MD, we used coarse-grained models of double tail lipid molecules that spontaneously self-assemble into bilayers. DFT provided equilibrium information on membrane structure. Experimental work was performed to further help elucidate the fundamental membrane organization principles.

  8. Model of ultrafast demagnetization driven by spin-orbit coupling in a photoexcited antiferromagnetic insulator Cr2O3

    Science.gov (United States)

    Guo, Feng; Zhang, Na; Jin, Wei; Chang, Jun

    2017-06-01

    We theoretically study the dynamic time evolution following laser pulse pumping in an antiferromagnetic insulator Cr2O3. From the photoexcited high-spin quartet states to the long-lived low-spin doublet states, the ultrafast demagnetization processes are investigated by solving the dissipative Schrödinger equation. We find that the demagnetization times are of the order of hundreds of femtoseconds, in good agreement with recent experiments. The switching times could be strongly reduced by properly tuning the energy gaps between the multiplet energy levels of Cr3+. Furthermore, the relaxation times also depend on the hybridization of atomic orbitals in the first photoexcited state. Our results suggest that the selective manipulation of the electronic structure by engineering stress-strain or chemical substitution allows effective control of the magnetic state switching in photoexcited insulating transition-metal oxides.

  9. Model Construct Based Enterprise Model Architecture and Its Modeling Approach

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In order to support enterprise integration, a kind of model construct based enterprise model architecture and its modeling approach are studied in this paper. First, the structural makeup and internal relationships of enterprise model architecture are discussed. Then, the concept of reusable model construct (MC) which belongs to the control view and can help to derive other views is proposed. The modeling approach based on model construct consists of three steps, reference model architecture synthesis, enterprise model customization, system design and implementation. According to MC based modeling approach a case study with the background of one-kind-product machinery manufacturing enterprises is illustrated. It is shown that proposal model construct based enterprise model architecture and modeling approach are practical and efficient.

  10. DTN Modeling in OPNET Modeler

    Directory of Open Access Journals (Sweden)

    PAPAJ Jan

    2014-05-01

    Full Text Available Traditional wireless networks use the concept of the point-to-point forwarding inherited from reliable wired networks which seems to be not ideal for wireless environment. New emerging applications and networks operate mostly disconnected. So-called Delay-Tolerant networks (DTNs are receiving increasing attentions from both academia and industry. DTNs introduced a store-carry-and-forward concept solving the problem of intermittent connectivity. Behavior of such networks is verified by real models, computer simulation or combination of the both approaches. Computer simulation has become the primary and cost effective tool for evaluating the performance of the DTNs. OPNET modeler is our target simulation tool and we wanted to spread OPNET’s simulation opportunity towards DTN. We implemented bundle protocol to OPNET modeler allowing simulate cases based on bundle concept as epidemic forwarding which relies on flooding the network with messages and the forwarding algorithm based on the history of past encounters (PRoPHET. The implementation details will be provided in article.

  11. A Model

    Institute of Scientific and Technical Information of China (English)

    Liu Zhiyang

    2011-01-01

    Similar to ISO Technical Committees,SAC Technical Committees undertake the management and coordination of standard's development and amendments in various sectors in industry,playing the role as a bridge among enterprises,research institutions and the governmental standardization administration.How to fully play the essential role is the vital issue SAC has been committing to resolve.Among hundreds of SAC TCs,one stands out in knitting together those isolated,scattered,but highly competitive enterprises in the same industry with the "Standards" thread,and achieving remarkable results in promoting industry development with standardization.It sets a role model for other TCs.

  12. Modelling Behaviour

    DEFF Research Database (Denmark)

    2015-01-01

    This book reflects and expands on the current trend in the building industry to understand, simulate and ultimately design buildings by taking into consideration the interlinked elements and forces that act on them. This approach overcomes the traditional, exclusive focus on building tasks, while....... The chapter authors were invited speakers at the 5th Symposium "Modelling Behaviour", which took place at the CITA in Copenhagen in September 2015....... posing new challenges in all areas of the industry from material and structural to the urban scale. Contributions from invited experts, papers and case studies provide the reader with a comprehensive overview of the field, as well as perspectives from related disciplines, such as computer science...

  13. Econometric modelling

    Directory of Open Access Journals (Sweden)

    M. Alguacil Marí

    2017-08-01

    Full Text Available The current economic environment, together with the low scores obtained by our students in recent years, makes it necessary to incorporate new teaching methods. In this sense, econometric modelling provides a unique opportunity offering to the student with the basic tools to address the study of Econometrics in a deeper and novel way. In this article, this teaching method is described, presenting also an example based on a recent study carried out by two students of the Degree of Economics. Likewise, the success of this method is evaluated quantitatively in terms of academic performance. The results confirm our initial idea that the greater involvement of the student, as well as the need for a more complete knowledge of the subject, suppose a stimulus for the study of this subject. As evidence of this, we show how those students who opted for the method we propose here obtained higher qualifications than those that chose the traditional method.

  14. Modelling Defiguration

    DEFF Research Database (Denmark)

    Bork Petersen, Franziska

    2013-01-01

    For the presentation of his autumn/winter 2012 collection in Paris and subsequently in Copenhagen, Danish designer Henrik Vibskov installed a mobile catwalk. The article investigates the choreographic impact of this scenography on those who move through it. Drawing on Dance Studies, the analytical...... advantageous manner. Stepping on the catwalk’s sloping, moving surfaces decelerates the models’ walk and makes it cautious, hesitant and shaky: suddenly the models lack exactly the affirmative, staccato, striving quality of motion, and the condescending expression that they perform on most contemporary...... catwalks. Vibskov’s catwalk induces what the dance scholar Gabriele Brandstetter has labelled a ‘defigurative choregoraphy’: a straying from definitions, which exist in ballet as in other movement-based genres, of how a figure should move and appear (1998). The catwalk scenography in this instance...

  15. X-ray characterization of mesophases of human telomeric G-quadruplexes and other DNA analogues.

    Science.gov (United States)

    Yasar, Selcuk; Schimelman, Jacob B; Aksoyoglu, M Alphan; Steinmetz, Nicole F; French, Roger H; Parsegian, V Adrian; Podgornik, Rudolf

    2016-06-02

    Observed in the folds of guanine-rich oligonucleotides, non-canonical G-quadruplex structures are based on G-quartets formed by hydrogen bonding and cation-coordination of guanosines. In dilute 5'-guanosine monophosphate (GMP) solutions, G-quartets form by the self-assembly of four GMP nucleotides. We use x-ray diffraction to characterize the columnar liquid-crystalline mesophases in concentrated solutions of various model G-quadruplexes. We then probe the transitions between mesophases by varying the PEG solution osmotic pressure, thus mimicking in vivo molecular crowding conditions. Using the GMP-quadruplex, built by the stacking of G-quartets with no covalent linking between them, as the baseline, we report the liquid-crystalline phase behaviors of two other related G-quadruplexes: (i) the intramolecular parallel-stranded G-quadruplex formed by the 22-mer four-repeat human telomeric sequence AG3(TTAG3)3 and (ii) the intermolecular parallel-stranded G-quadruplex formed by the TG4T oligonucleotides. Finally, we compare the mesophases of the G-quadruplexes, under PEG-induced crowding conditions, with the corresponding mesophases of the canonical duplex and triplex DNA analogues.

  16. X-ray characterization of mesophases of human telomeric G-quadruplexes and other DNA analogues

    Science.gov (United States)

    Yasar, Selcuk; Schimelman, Jacob B.; Aksoyoglu, M. Alphan; Steinmetz, Nicole F.; French, Roger H.; Parsegian, V. Adrian; Podgornik, Rudolf

    2016-06-01

    Observed in the folds of guanine-rich oligonucleotides, non-canonical G-quadruplex structures are based on G-quartets formed by hydrogen bonding and cation-coordination of guanosines. In dilute 5‧-guanosine monophosphate (GMP) solutions, G-quartets form by the self-assembly of four GMP nucleotides. We use x-ray diffraction to characterize the columnar liquid-crystalline mesophases in concentrated solutions of various model G-quadruplexes. We then probe the transitions between mesophases by varying the PEG solution osmotic pressure, thus mimicking in vivo molecular crowding conditions. Using the GMP-quadruplex, built by the stacking of G-quartets with no covalent linking between them, as the baseline, we report the liquid-crystalline phase behaviors of two other related G-quadruplexes: (i) the intramolecular parallel-stranded G-quadruplex formed by the 22-mer four-repeat human telomeric sequence AG3(TTAG3)3 and (ii) the intermolecular parallel-stranded G-quadruplex formed by the TG4T oligonucleotides. Finally, we compare the mesophases of the G-quadruplexes, under PEG-induced crowding conditions, with the corresponding mesophases of the canonical duplex and triplex DNA analogues.

  17. The temporal dynamics of global-to-local feedback in the formation of hierarchical motion patterns: psychophysics and computational simulations.

    Science.gov (United States)

    Hock, Howard S; Schöner, Gregor; Brownlow, Stacey; Taler, Dana

    2011-05-01

    Four motion quartets, each ambiguous with respect to the perception of parallel-path horizontal or vertical motion, were arranged in a diamond configuration. Both global parallel-path motion (the same motion axis for all the quartets), which is typical for multiquartet stimuli, and global rotational rocking are perceived. Experiment 1 indicated that rotational rocking is established at different levels of processing. Globally, larger displacements of each quartet's elements increase the angle of rotation and, thereby, the perception of rotational rocking. Locally, larger displacements have the opposite effect, weakening motion percepts. Experiment 2 showed that global-to-local feedback affects the local perception of rotation-consistent versus rotation-inconsistent motion directions. Experiment 3 provided evidence for hysteresis effects indicative of competition between global rotational rocking and parallel-path motion. The experimental results were simulated by a two-level dynamical model incorporating global-to-local feedback, with recurrent feedforward/feedback loops creating detection instabilities that amplify activation at both global and local levels of the rotational-rocking pattern.

  18. On Activity modelling in process modeling

    Directory of Open Access Journals (Sweden)

    Dorel Aiordachioaie

    2001-12-01

    Full Text Available The paper is looking to the dynamic feature of the meta-models of the process modelling process, the time. Some principles are considered and discussed as main dimensions of any modelling activity: the compatibility of the substances, the equipresence of phenomena and the solvability of the model. The activity models are considered and represented at meta-level.

  19. Towards a Multi Business Model Innovation Model

    DEFF Research Database (Denmark)

    Lindgren, Peter; Jørgensen, Rasmus

    2012-01-01

    This paper studies the evolution of business model (BM) innovations related to a multi business model framework. The paper tries to answer the research questions: • What are the requirements for a multi business model innovation model (BMIM)? • How should a multi business model innovation model...... look like? Different generations of BMIMs are initially studied in the context of laying the baseline for how next generation multi BM Innovation model (BMIM) should look like. All generations of models are analyzed with the purpose of comparing the characteristics and challenges of previous...

  20. Better Language Models with Model Merging

    CERN Document Server

    Brants, T

    1996-01-01

    This paper investigates model merging, a technique for deriving Markov models from text or speech corpora. Models are derived by starting with a large and specific model and by successively combining states to build smaller and more general models. We present methods to reduce the time complexity of the algorithm and report on experiments on deriving language models for a speech recognition task. The experiments show the advantage of model merging over the standard bigram approach. The merged model assigns a lower perplexity to the test set and uses considerably fewer states.

  1. Model Selection Principles in Misspecified Models

    CERN Document Server

    Lv, Jinchi

    2010-01-01

    Model selection is of fundamental importance to high dimensional modeling featured in many contemporary applications. Classical principles of model selection include the Kullback-Leibler divergence principle and the Bayesian principle, which lead to the Akaike information criterion and Bayesian information criterion when models are correctly specified. Yet model misspecification is unavoidable when we have no knowledge of the true model or when we have the correct family of distributions but miss some true predictor. In this paper, we propose a family of semi-Bayesian principles for model selection in misspecified models, which combine the strengths of the two well-known principles. We derive asymptotic expansions of the semi-Bayesian principles in misspecified generalized linear models, which give the new semi-Bayesian information criteria (SIC). A specific form of SIC admits a natural decomposition into the negative maximum quasi-log-likelihood, a penalty on model dimensionality, and a penalty on model miss...

  2. The IMACLIM model; Le modele IMACLIM

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This document provides annexes to the IMACLIM model which propose an actualized description of IMACLIM, model allowing the design of an evaluation tool of the greenhouse gases reduction policies. The model is described in a version coupled with the POLES, technical and economical model of the energy industry. Notations, equations, sources, processing and specifications are proposed and detailed. (A.L.B.)

  3. Building Mental Models by Dissecting Physical Models

    Science.gov (United States)

    Srivastava, Anveshna

    2016-01-01

    When students build physical models from prefabricated components to learn about model systems, there is an implicit trade-off between the physical degrees of freedom in building the model and the intensity of instructor supervision needed. Models that are too flexible, permitting multiple possible constructions require greater supervision to…

  4. The IMACLIM model; Le modele IMACLIM

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2003-07-01

    This document provides annexes to the IMACLIM model which propose an actualized description of IMACLIM, model allowing the design of an evaluation tool of the greenhouse gases reduction policies. The model is described in a version coupled with the POLES, technical and economical model of the energy industry. Notations, equations, sources, processing and specifications are proposed and detailed. (A.L.B.)

  5. Helena liinid / Anneli Remme

    Index Scriptorium Estoniae

    Remme, Anneli, 1968-

    2008-01-01

    Helena Tulve autoriplaadist "Lijnen". Esitavad NYYD Ensemble, dirigent Olari Elts, Stockholm Saxophone Quartet, Silesian String Quartet, solistid Arianna Savall, Emmanuelle Ophele-Gaubert ja Mihkel Peäske

  6. Helena liinid / Anneli Remme

    Index Scriptorium Estoniae

    Remme, Anneli, 1968-

    2008-01-01

    Helena Tulve autoriplaadist "Lijnen". Esitavad NYYD Ensemble, dirigent Olari Elts, Stockholm Saxophone Quartet, Silesian String Quartet, solistid Arianna Savall, Emmanuelle Ophele-Gaubert ja Mihkel Peäske

  7. Modelling live forensic acquisition

    CSIR Research Space (South Africa)

    Grobler, MM

    2009-06-01

    Full Text Available This paper discusses the development of a South African model for Live Forensic Acquisition - Liforac. The Liforac model is a comprehensive model that presents a range of aspects related to Live Forensic Acquisition. The model provides forensic...

  8. Continuous Time Model Estimation

    OpenAIRE

    Carl Chiarella; Shenhuai Gao

    2004-01-01

    This paper introduces an easy to follow method for continuous time model estimation. It serves as an introduction on how to convert a state space model from continuous time to discrete time, how to decompose a hybrid stochastic model into a trend model plus a noise model, how to estimate the trend model by simulation, and how to calculate standard errors from estimation of the noise model. It also discusses the numerical difficulties involved in discrete time models that bring about the unit ...

  9. Comparative Protein Structure Modeling Using MODELLER.

    Science.gov (United States)

    Webb, Benjamin; Sali, Andrej

    2016-06-20

    Comparative protein structure modeling predicts the three-dimensional structure of a given protein sequence (target) based primarily on its alignment to one or more proteins of known structure (templates). The prediction process consists of fold assignment, target-template alignment, model building, and model evaluation. This unit describes how to calculate comparative models using the program MODELLER and how to use the ModBase database of such models, and discusses all four steps of comparative modeling, frequently observed errors, and some applications. Modeling lactate dehydrogenase from Trichomonas vaginalis (TvLDH) is described as an example. The download and installation of the MODELLER software is also described. © 2016 by John Wiley & Sons, Inc.

  10. Concept Modeling vs. Data modeling in Practice

    DEFF Research Database (Denmark)

    Madsen, Bodil Nistrup; Erdman Thomsen, Hanne

    2015-01-01

    account of the inheritance of characteristics and allows us to introduce a number of principles and constraints which render concept modeling more coherent than earlier approaches. Second, we explain how terminological ontologies can be used as the basis for developing conceptual and logical data models......This chapter shows the usefulness of terminological concept modeling as a first step in data modeling. First, we introduce terminological concept modeling with terminological ontologies, i.e. concept systems enriched with characteristics modeled as feature specifications. This enables a formal...

  11. Business Model Innovation

    OpenAIRE

    Dodgson, Mark; Gann, David; Phillips, Nelson; Massa, Lorenzo; Tucci, Christopher

    2014-01-01

    The chapter offers a broad review of the literature at the nexus between Business Models and innovation studies, and examines the notion of Business Model Innovation in three different situations: Business Model Design in newly formed organizations, Business Model Reconfiguration in incumbent firms, and Business Model Innovation in the broad context of sustainability. Tools and perspectives to make sense of Business Models and support managers and entrepreneurs in dealing with Business Model ...

  12. Modeling cholera outbreaks.

    Science.gov (United States)

    Chao, Dennis L; Longini, Ira M; Morris, J Glenn

    2014-01-01

    Mathematical modeling can be a valuable tool for studying infectious disease outbreak dynamics and simulating the effects of possible interventions. Here, we describe approaches to modeling cholera outbreaks and how models have been applied to explore intervention strategies, particularly in Haiti. Mathematical models can play an important role in formulating and evaluating complex cholera outbreak response options. Major challenges to cholera modeling are insufficient data for calibrating models and the need to tailor models for different outbreak scenarios.

  13. Modeling cholera outbreaks

    Science.gov (United States)

    Longini, Ira M.; Morris, J. Glenn

    2014-01-01

    Mathematical modeling can be a valuable tool for studying infectious disease outbreak dynamics and simulating the effects of possible interventions. Here, we describe approaches to modeling cholera outbreaks and how models have been applied to explore intervention strategies, particularly in Haiti. Mathematical models can play an important role in formulating and evaluating complex cholera outbreak response options. Major challenges to cholera modeling are insufficient data for calibrating models and the need to tailor models for different outbreak scenarios. PMID:23412687

  14. Model Manipulation for End-User Modelers

    DEFF Research Database (Denmark)

    Acretoaie, Vlad

    of these proposals. To achieve its first goal, the thesis presents the findings of a Systematic Mapping Study showing that human factors topics are scarcely and relatively poorly addressed in model transformation research. Motivated by these findings, the thesis explores the requirements of end-user modelers......End-user modelers are domain experts who create and use models as part of their work. They are typically not Software Engineers, and have little or no programming and meta-modeling experience. However, using model manipulation languages developed in the context of Model-Driven Engineering often...... requires such experience. These languages are therefore only used by a small subset of the modelers that could, in theory, benefit from them. The goals of this thesis are to substantiate this observation, introduce the concepts and tools required to overcome it, and provide empirical evidence in support...

  15. Air Quality Dispersion Modeling - Alternative Models

    Science.gov (United States)

    Models, not listed in Appendix W, that can be used in regulatory applications with case-by-case justification to the Reviewing Authority as noted in Section 3.2, Use of Alternative Models, in Appendix W.

  16. From Product Models to Product State Models

    DEFF Research Database (Denmark)

    Larsen, Michael Holm

    1999-01-01

    A well-known technology designed to handle product data is Product Models. Product Models are in their current form not able to handle all types of product state information. Hence, the concept of a Product State Model (PSM) is proposed. The PSM and in particular how to model a PSM is the Research...... Object for this project. In the presentation, benefits and challenges of the PSM will be presented as a basis for the discussion....

  17. Measurement and Modeling: Infectious Disease Modeling

    NARCIS (Netherlands)

    Kretzschmar, MEE

    2016-01-01

    After some historical remarks about the development of mathematical theory for infectious disease dynamics we introduce a basic mathematical model for the spread of an infection with immunity. The concepts of the model are explained and the model equations are derived from first principles. Using th

  18. Modelling of Hydraulic Robot

    DEFF Research Database (Denmark)

    Madsen, Henrik; Zhou, Jianjun; Hansen, Lars Henrik

    1997-01-01

    This paper describes a case study of identifying the physical model (or the grey box model) of a hydraulic test robot. The obtained model is intended to provide a basis for model-based control of the robot. The physical model is formulated in continuous time and is derived by application...... of the laws of physics on the system. The unknown (or uncertain) parameters are estimated with Maximum Likelihood (ML) parameter estimation. The identified model has been evaluated by comparing the measurements with simulation of the model. The identified model was much more capable of describing the dynamics...... of the system than the deterministic model....

  19. Product and Process Modelling

    DEFF Research Database (Denmark)

    Cameron, Ian T.; Gani, Rafiqul

    This book covers the area of product and process modelling via a case study approach. It addresses a wide range of modelling applications with emphasis on modelling methodology and the subsequent in-depth analysis of mathematical models to gain insight via structural aspects of the models. These ...

  20. "Bohr's Atomic Model."

    Science.gov (United States)

    Willden, Jeff

    2001-01-01

    "Bohr's Atomic Model" is a small interactive multimedia program that introduces the viewer to a simplified model of the atom. This interactive simulation lets students build an atom using an atomic construction set. The underlying design methodology for "Bohr's Atomic Model" is model-centered instruction, which means the central model of the…

  1. Modelling of Hydraulic Robot

    DEFF Research Database (Denmark)

    Madsen, Henrik; Zhou, Jianjun; Hansen, Lars Henrik

    1997-01-01

    This paper describes a case study of identifying the physical model (or the grey box model) of a hydraulic test robot. The obtained model is intended to provide a basis for model-based control of the robot. The physical model is formulated in continuous time and is derived by application...

  2. Forest-fire models

    Science.gov (United States)

    Haiganoush Preisler; Alan Ager

    2013-01-01

    For applied mathematicians forest fire models refer mainly to a non-linear dynamic system often used to simulate spread of fire. For forest managers forest fire models may pertain to any of the three phases of fire management: prefire planning (fire risk models), fire suppression (fire behavior models), and postfire evaluation (fire effects and economic models). In...

  3. Solicited abstract: Global hydrological modeling and models

    Science.gov (United States)

    Xu, Chong-Yu

    2010-05-01

    The origins of rainfall-runoff modeling in the broad sense can be found in the middle of the 19th century arising in response to three types of engineering problems: (1) urban sewer design, (2) land reclamation drainage systems design, and (3) reservoir spillway design. Since then numerous empirical, conceptual and physically-based models are developed including event based models using unit hydrograph concept, Nash's linear reservoir models, HBV model, TOPMODEL, SHE model, etc. From the late 1980s, the evolution of global and continental-scale hydrology has placed new demands on hydrologic modellers. The macro-scale hydrological (global and regional scale) models were developed on the basis of the following motivations (Arenll, 1999). First, for a variety of operational and planning purposes, water resource managers responsible for large regions need to estimate the spatial variability of resources over large areas, at a spatial resolution finer than can be provided by observed data alone. Second, hydrologists and water managers are interested in the effects of land-use and climate variability and change over a large geographic domain. Third, there is an increasing need of using hydrologic models as a base to estimate point and non-point sources of pollution loading to streams. Fourth, hydrologists and atmospheric modellers have perceived weaknesses in the representation of hydrological processes in regional and global climate models, and developed global hydrological models to overcome the weaknesses of global climate models. Considerable progress in the development and application of global hydrological models has been achieved to date, however, large uncertainties still exist considering the model structure including large scale flow routing, parameterization, input data, etc. This presentation will focus on the global hydrological models, and the discussion includes (1) types of global hydrological models, (2) procedure of global hydrological model development

  4. Bayesian Model Selection and Statistical Modeling

    CERN Document Server

    Ando, Tomohiro

    2010-01-01

    Bayesian model selection is a fundamental part of the Bayesian statistical modeling process. The quality of these solutions usually depends on the goodness of the constructed Bayesian model. Realizing how crucial this issue is, many researchers and practitioners have been extensively investigating the Bayesian model selection problem. This book provides comprehensive explanations of the concepts and derivations of the Bayesian approach for model selection and related criteria, including the Bayes factor, the Bayesian information criterion (BIC), the generalized BIC, and the pseudo marginal lik

  5. From Numeric Models to Granular System Modeling

    Directory of Open Access Journals (Sweden)

    Witold Pedrycz

    2015-03-01

    To make this study self-contained, we briefly recall the key concepts of granular computing and demonstrate how this conceptual framework and its algorithmic fundamentals give rise to granular models. We discuss several representative formal setups used in describing and processing information granules including fuzzy sets, rough sets, and interval calculus. Key architectures of models dwell upon relationships among information granules. We demonstrate how information granularity and its optimization can be regarded as an important design asset to be exploited in system modeling and giving rise to granular models. With this regard, an important category of rule-based models along with their granular enrichments is studied in detail.

  6. Geologic Framework Model Analysis Model Report

    Energy Technology Data Exchange (ETDEWEB)

    R. Clayton

    2000-12-19

    The purpose of this report is to document the Geologic Framework Model (GFM), Version 3.1 (GFM3.1) with regard to data input, modeling methods, assumptions, uncertainties, limitations, and validation of the model results, qualification status of the model, and the differences between Version 3.1 and previous versions. The GFM represents a three-dimensional interpretation of the stratigraphy and structural features of the location of the potential Yucca Mountain radioactive waste repository. The GFM encompasses an area of 65 square miles (170 square kilometers) and a volume of 185 cubic miles (771 cubic kilometers). The boundaries of the GFM were chosen to encompass the most widely distributed set of exploratory boreholes (the Water Table or WT series) and to provide a geologic framework over the area of interest for hydrologic flow and radionuclide transport modeling through the unsaturated zone (UZ). The depth of the model is constrained by the inferred depth of the Tertiary-Paleozoic unconformity. The GFM was constructed from geologic map and borehole data. Additional information from measured stratigraphy sections, gravity profiles, and seismic profiles was also considered. This interim change notice (ICN) was prepared in accordance with the Technical Work Plan for the Integrated Site Model Process Model Report Revision 01 (CRWMS M&O 2000). The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. The GFM is one component of the Integrated Site Model (ISM) (Figure l), which has been developed to provide a consistent volumetric portrayal of the rock layers, rock properties, and mineralogy of the Yucca Mountain site. The ISM consists of three components: (1) Geologic Framework Model (GFM); (2) Rock Properties Model (RPM); and (3) Mineralogic Model (MM). The ISM merges the detailed project stratigraphy into model stratigraphic units that are most useful for the primary downstream models and the

  7. Model Theory and Applications

    CERN Document Server

    Mangani, P

    2011-01-01

    This title includes: Lectures - G.E. Sacks - Model theory and applications, and H.J. Keisler - Constructions in model theory; and, Seminars - M. Servi - SH formulas and generalized exponential, and J.A. Makowski - Topological model theory.

  8. Wildfire Risk Main Model

    Data.gov (United States)

    Earth Data Analysis Center, University of New Mexico — The model combines three modeled fire behavior parameters (rate of spread, flame length, crown fire potential) and one modeled ecological health measure (fire regime...

  9. Energy modelling software

    CSIR Research Space (South Africa)

    Osburn, L

    2010-01-01

    Full Text Available The construction industry has turned to energy modelling in order to assist them in reducing the amount of energy consumed by buildings. However, while the energy loads of buildings can be accurately modelled, energy models often under...

  10. Computational neurogenetic modeling

    CERN Document Server

    Benuskova, Lubica

    2010-01-01

    Computational Neurogenetic Modeling is a student text, introducing the scope and problems of a new scientific discipline - Computational Neurogenetic Modeling (CNGM). CNGM is concerned with the study and development of dynamic neuronal models for modeling brain functions with respect to genes and dynamic interactions between genes. These include neural network models and their integration with gene network models. This new area brings together knowledge from various scientific disciplines, such as computer and information science, neuroscience and cognitive science, genetics and molecular biol

  11. Predictive Models for Music

    OpenAIRE

    Paiement, Jean-François; Grandvalet, Yves; Bengio, Samy

    2008-01-01

    Modeling long-term dependencies in time series has proved very difficult to achieve with traditional machine learning methods. This problem occurs when considering music data. In this paper, we introduce generative models for melodies. We decompose melodic modeling into two subtasks. We first propose a rhythm model based on the distributions of distances between subsequences. Then, we define a generative model for melodies given chords and rhythms based on modeling sequences of Narmour featur...

  12. TRACKING CLIMATE MODELS

    Data.gov (United States)

    National Aeronautics and Space Administration — CLAIRE MONTELEONI*, GAVIN SCHMIDT, AND SHAILESH SAROHA* Climate models are complex mathematical models designed by meteorologists, geophysicists, and climate...

  13. Environmental Modeling Center

    Data.gov (United States)

    Federal Laboratory Consortium — The Environmental Modeling Center provides the computational tools to perform geostatistical analysis, to model ground water and atmospheric releases for comparison...

  14. Multilevel modeling using R

    CERN Document Server

    Finch, W Holmes; Kelley, Ken

    2014-01-01

    A powerful tool for analyzing nested designs in a variety of fields, multilevel/hierarchical modeling allows researchers to account for data collected at multiple levels. Multilevel Modeling Using R provides you with a helpful guide to conducting multilevel data modeling using the R software environment.After reviewing standard linear models, the authors present the basics of multilevel models and explain how to fit these models using R. They then show how to employ multilevel modeling with longitudinal data and demonstrate the valuable graphical options in R. The book also describes models fo

  15. Global Business Models

    DEFF Research Database (Denmark)

    Rask, Morten

    insight from the literature about business models, international product policy, international entry modes and globalization into a conceptual model of relevant design elements of global business models, enabling global business model innovation to deal with differences in a downstream perspective...... regarding the customer interface and in an upstream perspective regarding the supply infrastructure. The paper offers a coherent conceptual dynamic meta-model of global business model innovation. Students, scholars and managers within the field of international business can use this conceptualization...... to understand, to study, and to create global business model innovation. Managerial and research implications draw on the developed ideal type of global business model innovation....

  16. Continuous system modeling

    Science.gov (United States)

    Cellier, Francois E.

    1991-01-01

    A comprehensive and systematic introduction is presented for the concepts associated with 'modeling', involving the transition from a physical system down to an abstract description of that system in the form of a set of differential and/or difference equations, and basing its treatment of modeling on the mathematics of dynamical systems. Attention is given to the principles of passive electrical circuit modeling, planar mechanical systems modeling, hierarchical modular modeling of continuous systems, and bond-graph modeling. Also discussed are modeling in equilibrium thermodynamics, population dynamics, and system dynamics, inductive reasoning, artificial neural networks, and automated model synthesis.

  17. Understandings of 'Modelling'

    DEFF Research Database (Denmark)

    Andresen, Mette

    2007-01-01

    This paper meets the common critique of the teaching of non-authentic modelling in school mathematics. In the paper, non-authentic modelling is related to a change of view on the intentions of modelling from knowledge about applications of mathematical models to modelling for concept formation. Non......-authentic modelling is also linked with the potentials of exploration of ready-made models as a forerunner for more authentic modelling processes. The discussion includes analysis of an episode of students? work in the classroom, which serves to illustrate how concept formation may be linked to explorations of a non...

  18. Interfacing materials models with fire field models

    Energy Technology Data Exchange (ETDEWEB)

    Nicolette, V.F.; Tieszen, S.R.; Moya, J.L.

    1995-12-01

    For flame spread over solid materials, there has traditionally been a large technology gap between fundamental combustion research and the somewhat simplistic approaches used for practical, real-world applications. Recent advances in computational hardware and computational fluid dynamics (CFD)-based software have led to the development of fire field models. These models, when used in conjunction with material burning models, have the potential to bridge the gap between research and application by implementing physics-based engineering models in a transient, multi-dimensional tool. This paper discusses the coupling that is necessary between fire field models and burning material models for the simulation of solid material fires. Fire field models are capable of providing detailed information about the local fire environment. This information serves as an input to the solid material combustion submodel, which subsequently calculates the impact of the fire environment on the material. The response of the solid material (in terms of thermal response, decomposition, charring, and off-gassing) is then fed back into the field model as a source of mass, momentum and energy. The critical parameters which must be passed between the field model and the material burning model have been identified. Many computational issues must be addressed when developing such an interface. Some examples include the ability to track multiple fuels and species, local ignition criteria, and the need to use local grid refinement over the burning material of interest.

  19. Combustion modeling in a model combustor

    Institute of Scientific and Technical Information of China (English)

    L.Y.Jiang; I.Campbell; K.Su

    2007-01-01

    The flow-field of a propane-air diffusion flame combustor with interior and exterior conjugate heat transfers was numerically studied.Results obtained from four combustion models,combined with the re-normalization group (RNG) k-ε turbulence model,discrete ordinates radiation model and enhanced wall treatment are presented and discussed.The results are compared with a comprehensive database obtained from a series of experimental measurements.The flow patterns and the recirculation zone length in the combustion chamber are accurately predicted,and the mean axial velocities are in fairly good agreement with the experimental data,particularly at downstream sections for all four combustion models.The mean temperature profiles are captured fairly well by the eddy dissipation (EDS),probability density function (PDF),and laminar flamelet combustion models.However,the EDS-finite-rate combustion model fails to provide an acceptable temperature field.In general,the flamelet model illustrates little superiority over the PDF model,and to some extent the PDF model shows better performance than the EDS model.

  20. BRST Quantization of a Sixth-Order Derivative Scalar Field Theory

    Science.gov (United States)

    Kim, Yong-Wan; Myung, Yun Soo; Park, Young-Jai

    2013-12-01

    We study a sixth-order derivative scalar field model in Minkowski spacetime as a toy model of higher-derivative critical gravity theories. This model is consistently quantized when using the Becchi-Rouet-Stora-Tyutin (BRST) quantization scheme even though it does not show gauge symmetry manifestly. Imposing a BRST quartet generated by two scalars and ghosts, there remains a nontrivial subspace with positive norm. This might be interpreted as a Minkowskian dual version of the unitary truncation in the logarithmic conformal field theory.

  1. BRST quantization of a sixth-order derivative scalar field theory

    CERN Document Server

    Kim, Yong-Wan; Park, Young-Jai

    2013-01-01

    We study a sixth order derivative scalar field model in Minkowski spacetime as a toy model of higher-derivative critical gravity theories. This model is consistently quantized when using the Becchi-Rouet-Stora-Tyutin (BRST) quantization scheme even though it does not show gauge symmetry manifestly. Imposing a BRST quartet generated by two scalars and ghosts, there remains a non-trivial subspace with positive norm. This might be interpreted as a Minkowskian dual version of the unitary truncation in the logarithmic conformal field theory.

  2. Regularized Structural Equation Modeling.

    Science.gov (United States)

    Jacobucci, Ross; Grimm, Kevin J; McArdle, John J

    A new method is proposed that extends the use of regularization in both lasso and ridge regression to structural equation models. The method is termed regularized structural equation modeling (RegSEM). RegSEM penalizes specific parameters in structural equation models, with the goal of creating easier to understand and simpler models. Although regularization has gained wide adoption in regression, very little has transferred to models with latent variables. By adding penalties to specific parameters in a structural equation model, researchers have a high level of flexibility in reducing model complexity, overcoming poor fitting models, and the creation of models that are more likely to generalize to new samples. The proposed method was evaluated through a simulation study, two illustrative examples involving a measurement model, and one empirical example involving the structural part of the model to demonstrate RegSEM's utility.

  3. Wastewater treatment models

    DEFF Research Database (Denmark)

    Gernaey, Krist; Sin, Gürkan

    2011-01-01

    The state-of-the-art level reached in modeling wastewater treatment plants (WWTPs) is reported. For suspended growth systems, WWTP models have evolved from simple description of biological removal of organic carbon and nitrogen in aeration tanks (ASM1 in 1987) to more advanced levels including...... of WWTP modeling by linking the wastewater treatment line with the sludge handling line in one modeling platform. Application of WWTP models is currently rather time consuming and thus expensive due to the high model complexity, and requires a great deal of process knowledge and modeling expertise....... Efficient and good modeling practice therefore requires the use of a proper set of guidelines, thus grounding the modeling studies on a general and systematic framework. Last but not least, general limitations of WWTP models – more specifically activated sludge models – are introduced since these define...

  4. Wastewater Treatment Models

    DEFF Research Database (Denmark)

    Gernaey, Krist; Sin, Gürkan

    2008-01-01

    The state-of-the-art level reached in modeling wastewater treatment plants (WWTPs) is reported. For suspended growth systems, WWTP models have evolved from simple description of biological removal of organic carbon and nitrogen in aeration tanks (ASM1 in 1987) to more advanced levels including...... the practice of WWTP modeling by linking the wastewater treatment line with the sludge handling line in one modeling platform. Application of WWTP models is currently rather time consuming and thus expensive due to the high model complexity, and requires a great deal of process knowledge and modeling expertise....... Efficient and good modeling practice therefore requires the use of a proper set of guidelines, thus grounding the modeling studies on a general and systematic framework. Last but not least, general limitations of WWTP models – more specifically, activated sludge models – are introduced since these define...

  5. ROCK PROPERTIES MODEL ANALYSIS MODEL REPORT

    Energy Technology Data Exchange (ETDEWEB)

    Clinton Lum

    2002-02-04

    The purpose of this Analysis and Model Report (AMR) is to document Rock Properties Model (RPM) 3.1 with regard to input data, model methods, assumptions, uncertainties and limitations of model results, and qualification status of the model. The report also documents the differences between the current and previous versions and validation of the model. The rock properties models are intended principally for use as input to numerical physical-process modeling, such as of ground-water flow and/or radionuclide transport. The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. This work was conducted in accordance with the following planning documents: WA-0344, ''3-D Rock Properties Modeling for FY 1998'' (SNL 1997, WA-0358), ''3-D Rock Properties Modeling for FY 1999'' (SNL 1999), and the technical development plan, Rock Properties Model Version 3.1, (CRWMS M&O 1999c). The Interim Change Notice (ICNs), ICN 02 and ICN 03, of this AMR were prepared as part of activities being conducted under the Technical Work Plan, TWP-NBS-GS-000003, ''Technical Work Plan for the Integrated Site Model, Process Model Report, Revision 01'' (CRWMS M&O 2000b). The purpose of ICN 03 is to record changes in data input status due to data qualification and verification activities. These work plans describe the scope, objectives, tasks, methodology, and implementing procedures for model construction. The constraints, caveats, and limitations associated with this model are discussed in the appropriate text sections that follow. The work scope for this activity consists of the following: (1) Conversion of the input data (laboratory measured porosity data, x-ray diffraction mineralogy, petrophysical calculations of bound water, and petrophysical calculations of porosity) for each borehole into stratigraphic coordinates; (2) Re-sampling and merging of data sets; (3

  6. Model Reduction of Nonlinear Fire Dynamics Models

    OpenAIRE

    Lattimer, Alan Martin

    2016-01-01

    Due to the complexity, multi-scale, and multi-physics nature of the mathematical models for fires, current numerical models require too much computational effort to be useful in design and real-time decision making, especially when dealing with fires over large domains. To reduce the computational time while retaining the complexity of the domain and physics, our research has focused on several reduced-order modeling techniques. Our contributions are improving wildland fire reduced-order mod...

  7. Better models are more effectively connected models

    Science.gov (United States)

    Nunes, João Pedro; Bielders, Charles; Darboux, Frederic; Fiener, Peter; Finger, David; Turnbull-Lloyd, Laura; Wainwright, John

    2016-04-01

    The concept of hydrologic and geomorphologic connectivity describes the processes and pathways which link sources (e.g. rainfall, snow and ice melt, springs, eroded areas and barren lands) to accumulation areas (e.g. foot slopes, streams, aquifers, reservoirs), and the spatial variations thereof. There are many examples of hydrological and sediment connectivity on a watershed scale; in consequence, a process-based understanding of connectivity is crucial to help managers understand their systems and adopt adequate measures for flood prevention, pollution mitigation and soil protection, among others. Modelling is often used as a tool to understand and predict fluxes within a catchment by complementing observations with model results. Catchment models should therefore be able to reproduce the linkages, and thus the connectivity of water and sediment fluxes within the systems under simulation. In modelling, a high level of spatial and temporal detail is desirable to ensure taking into account a maximum number of components, which then enables connectivity to emerge from the simulated structures and functions. However, computational constraints and, in many cases, lack of data prevent the representation of all relevant processes and spatial/temporal variability in most models. In most cases, therefore, the level of detail selected for modelling is too coarse to represent the system in a way in which connectivity can emerge; a problem which can be circumvented by representing fine-scale structures and processes within coarser scale models using a variety of approaches. This poster focuses on the results of ongoing discussions on modelling connectivity held during several workshops within COST Action Connecteur. It assesses the current state of the art of incorporating the concept of connectivity in hydrological and sediment models, as well as the attitudes of modellers towards this issue. The discussion will focus on the different approaches through which connectivity

  8. Multiple Model Approaches to Modelling and Control,

    DEFF Research Database (Denmark)

    on the ease with which prior knowledge can be incorporated. It is interesting to note that researchers in Control Theory, Neural Networks,Statistics, Artificial Intelligence and Fuzzy Logic have more or less independently developed very similar modelling methods, calling them Local ModelNetworks, Operating...... of introduction of existing knowledge, as well as the ease of model interpretation. This book attempts to outlinemuch of the common ground between the various approaches, encouraging the transfer of ideas.Recent progress in algorithms and analysis is presented, with constructive algorithms for automated model...

  9. Integrity modelling of tropospheric delay models

    Science.gov (United States)

    Rózsa, Szabolcs; Bastiaan Ober, Pieter; Mile, Máté; Ambrus, Bence; Juni, Ildikó

    2017-04-01

    The effect of the neutral atmosphere on signal propagation is routinely estimated by various tropospheric delay models in satellite navigation. Although numerous studies can be found in the literature investigating the accuracy of these models, for safety-of-life applications it is crucial to study and model the worst case performance of these models using very low recurrence frequencies. The main objective of the INTegrity of TROpospheric models (INTRO) project funded by the ESA PECS programme is to establish a model (or models) of the residual error of existing tropospheric delay models for safety-of-life applications. Such models are required to overbound rare tropospheric delays and should thus include the tails of the error distributions. Their use should lead to safe error bounds on the user position and should allow computation of protection levels for the horizontal and vertical position errors. The current tropospheric model from the RTCA SBAS Minimal Operational Standards has an associated residual error that equals 0.12 meters in the vertical direction. This value is derived by simply extrapolating the observed distribution of the residuals into the tail (where no data is present) and then taking the point where the cumulative distribution has an exceedance level would be 10-7.While the resulting standard deviation is much higher than the estimated standard variance that best fits the data (0.05 meters), it surely is conservative for most applications. In the context of the INTRO project some widely used and newly developed tropospheric delay models (e.g. RTCA MOPS, ESA GALTROPO and GPT2W) were tested using 16 years of daily ERA-INTERIM Reanalysis numerical weather model data and the raytracing technique. The results showed that the performance of some of the widely applied models have a clear seasonal dependency and it is also affected by a geographical position. In order to provide a more realistic, but still conservative estimation of the residual

  10. Numerical Modelling of Streams

    DEFF Research Database (Denmark)

    Vestergaard, Kristian

    In recent years there has been a sharp increase in the use of numerical water quality models. Numeric water quality modeling can be divided into three steps: Hydrodynamic modeling for the determination of stream flow and water levels. Modelling of transport and dispersion of a conservative...

  11. Graphical Models with R

    DEFF Research Database (Denmark)

    Højsgaard, Søren; Edwards, David; Lauritzen, Steffen

    , the book provides examples of how more advanced aspects of graphical modeling can be represented and handled within R. Topics covered in the seven chapters include graphical models for contingency tables, Gaussian and mixed graphical models, Bayesian networks and modeling high dimensional data...

  12. Dynamic Latent Classification Model

    DEFF Research Database (Denmark)

    Zhong, Shengtong; Martínez, Ana M.; Nielsen, Thomas Dyhre

    as possible. Motivated by this problem setting, we propose a generative model for dynamic classification in continuous domains. At each time point the model can be seen as combining a naive Bayes model with a mixture of factor analyzers (FA). The latent variables of the FA are used to capture the dynamics...... in the process as well as modeling dependences between attributes....

  13. HRM: HII Region Models

    Science.gov (United States)

    Wenger, Trey V.; Kepley, Amanda K.; Balser, Dana S.

    2017-07-01

    HII Region Models fits HII region models to observed radio recombination line and radio continuum data. The algorithm includes the calculations of departure coefficients to correct for non-LTE effects. HII Region Models has been used to model star formation in the nucleus of IC 342.

  14. Multilevel IRT Model Assessment

    NARCIS (Netherlands)

    Fox, Jean-Paul; Ark, L. Andries; Croon, Marcel A.

    2005-01-01

    Modelling complex cognitive and psychological outcomes in, for example, educational assessment led to the development of generalized item response theory (IRT) models. A class of models was developed to solve practical and challenging educational problems by generalizing the basic IRT models. An IRT

  15. Models for Dynamic Applications

    DEFF Research Database (Denmark)

    2011-01-01

    be applied to formulate, analyse and solve these dynamic problems and how in the case of the fuel cell problem the model consists of coupledmeso and micro scale models. It is shown how data flows are handled between the models and how the solution is obtained within the modelling environment....

  16. Multivariate GARCH models

    DEFF Research Database (Denmark)

    Silvennoinen, Annastiina; Teräsvirta, Timo

    This article contains a review of multivariate GARCH models. Most common GARCH models are presented and their properties considered. This also includes nonparametric and semiparametric models. Existing specification and misspecification tests are discussed. Finally, there is an empirical example...... in which several multivariate GARCH models are fitted to the same data set and the results compared....

  17. The Model Confidence Set

    DEFF Research Database (Denmark)

    Hansen, Peter Reinhard; Lunde, Asger; Nason, James M.

    The paper introduces the model confidence set (MCS) and applies it to the selection of models. A MCS is a set of models that is constructed such that it will contain the best model with a given level of confidence. The MCS is in this sense analogous to a confidence interval for a parameter. The M...

  18. Modelling Railway Interlocking Systems

    DEFF Research Database (Denmark)

    Lindegaard, Morten Peter; Viuf, P.; Haxthausen, Anne Elisabeth

    2000-01-01

    In this report we present a model of interlocking systems, and describe how the model may be validated by simulation. Station topologies are modelled by graphs in which the nodes denote track segments, and the edges denote connectivity for train traÆc. Points and signals are modelled by annotatio...

  19. AIDS Epidemiological models

    Science.gov (United States)

    Rahmani, Fouad Lazhar

    2010-11-01

    The aim of this paper is to present mathematical modelling of the spread of infection in the context of the transmission of the human immunodeficiency virus (HIV) and the acquired immune deficiency syndrome (AIDS). These models are based in part on the models suggested in the field of th AIDS mathematical modelling as reported by ISHAM [6].

  20. Multivariate GARCH models

    DEFF Research Database (Denmark)

    Silvennoinen, Annastiina; Teräsvirta, Timo

    This article contains a review of multivariate GARCH models. Most common GARCH models are presented and their properties considered. This also includes nonparametric and semiparametric models. Existing specification and misspecification tests are discussed. Finally, there is an empirical example...... in which several multivariate GARCH models are fitted to the same data set and the results compared....

  1. Multilevel IRT Model Assessment

    NARCIS (Netherlands)

    Fox, Gerardus J.A.; Ark, L. Andries; Croon, Marcel A.

    2005-01-01

    Modelling complex cognitive and psychological outcomes in, for example, educational assessment led to the development of generalized item response theory (IRT) models. A class of models was developed to solve practical and challenging educational problems by generalizing the basic IRT models. An IRT

  2. Biomass Scenario Model

    Energy Technology Data Exchange (ETDEWEB)

    2015-09-01

    The Biomass Scenario Model (BSM) is a unique, carefully validated, state-of-the-art dynamic model of the domestic biofuels supply chain which explicitly focuses on policy issues, their feasibility, and potential side effects. It integrates resource availability, physical/technological/economic constraints, behavior, and policy. The model uses a system dynamics simulation (not optimization) to model dynamic interactions across the supply chain.

  3. Lumped-parameter models

    Energy Technology Data Exchange (ETDEWEB)

    Ibsen, Lars Bo; Liingaard, M.

    2006-12-15

    A lumped-parameter model represents the frequency dependent soil-structure interaction of a massless foundation placed on or embedded into an unbounded soil domain. In this technical report the steps of establishing a lumped-parameter model are presented. Following sections are included in this report: Static and dynamic formulation, Simple lumped-parameter models and Advanced lumped-parameter models. (au)

  4. Plant development models

    NARCIS (Netherlands)

    Chuine, I.; Garcia de Cortazar-Atauri, I.; Kramer, K.; Hänninen, H.

    2013-01-01

    In this chapter we provide a brief overview of plant phenology modeling, focusing on mechanistic phenological models. After a brief history of plant phenology modeling, we present the different models which have been described in the literature so far and highlight the main differences between them,

  5. Generic Market Models

    NARCIS (Netherlands)

    R. Pietersz (Raoul); M. van Regenmortel

    2005-01-01

    textabstractCurrently, there are two market models for valuation and risk management of interest rate derivatives, the LIBOR and swap market models. In this paper, we introduce arbitrage-free constant maturity swap (CMS) market models and generic market models featuring forward rates that span perio

  6. A Model for Conversation

    DEFF Research Database (Denmark)

    Ayres, Phil

    2012-01-01

    This essay discusses models. It examines what models are, the roles models perform and suggests various intentions that underlie their construction and use. It discusses how models act as a conversational partner, and how they support various forms of conversation within the conversational activity...... of design. Three distinctions are drawn through which to develop this discussion of models in an architectural context. An examination of these distinctions serves to nuance particular characteristics and roles of models, the modelling activity itself and those engaged in it....

  7. Talk about toy models

    Science.gov (United States)

    Luczak, Joshua

    2017-02-01

    Scientific models are frequently discussed in philosophy of science. A great deal of the discussion is centred on approximation, idealisation, and on how these models achieve their representational function. Despite the importance, distinct nature, and high presence of toy models, they have received little attention from philosophers. This paper hopes to remedy this situation. It aims to elevate the status of toy models: by distinguishing them from approximations and idealisations, by highlighting and elaborating on several ways the Kac ring, a simple statistical mechanical model, is used as a toy model, and by explaining why toy models can be used to successfully carry out important work without performing a representational function.

  8. Latent classification models

    DEFF Research Database (Denmark)

    Langseth, Helge; Nielsen, Thomas Dyhre

    2005-01-01

    One of the simplest, and yet most consistently well-performing setof classifiers is the \\NB models. These models rely on twoassumptions: $(i)$ All the attributes used to describe an instanceare conditionally independent given the class of that instance,and $(ii)$ all attributes follow a specific...... parametric family ofdistributions.  In this paper we propose a new set of models forclassification in continuous domains, termed latent classificationmodels. The latent classification model can roughly be seen ascombining the \\NB model with a mixture of factor analyzers,thereby relaxing the assumptions...... classification model, and wedemonstrate empirically that the accuracy of the proposed model issignificantly higher than the accuracy of other probabilisticclassifiers....

  9. Wastewater treatment models

    DEFF Research Database (Denmark)

    Gernaey, Krist; Sin, Gürkan

    2011-01-01

    The state-of-the-art level reached in modeling wastewater treatment plants (WWTPs) is reported. For suspended growth systems, WWTP models have evolved from simple description of biological removal of organic carbon and nitrogen in aeration tanks (ASM1 in 1987) to more advanced levels including...... of WWTP modeling by linking the wastewater treatment line with the sludge handling line in one modeling platform. Application of WWTP models is currently rather time consuming and thus expensive due to the high model complexity, and requires a great deal of process knowledge and modeling expertise...

  10. Wastewater Treatment Models

    DEFF Research Database (Denmark)

    Gernaey, Krist; Sin, Gürkan

    2008-01-01

    The state-of-the-art level reached in modeling wastewater treatment plants (WWTPs) is reported. For suspended growth systems, WWTP models have evolved from simple description of biological removal of organic carbon and nitrogen in aeration tanks (ASM1 in 1987) to more advanced levels including...... the practice of WWTP modeling by linking the wastewater treatment line with the sludge handling line in one modeling platform. Application of WWTP models is currently rather time consuming and thus expensive due to the high model complexity, and requires a great deal of process knowledge and modeling expertise...

  11. The Hospitable Meal Model

    DEFF Research Database (Denmark)

    Justesen, Lise; Overgaard, Svend Skafte

    2017-01-01

    This article presents an analytical model that aims to conceptualize how meal experiences are framed when taking into account a dynamic understanding of hospitality: the meal model is named The Hospitable Meal Model. The idea behind The Hospitable Meal Model is to present a conceptual model...... that can serve as a frame for developing hospitable meal competencies among professionals working within the area of institutional foodservices as well as a conceptual model for analysing meal experiences. The Hospitable Meal Model transcends and transforms existing meal models by presenting a more open......-ended approach towards meal experiences. The underlying purpose of The Hospitable Meal Model is to provide the basis for creating value for the individuals involved in institutional meal services. The Hospitable Meal Model was developed on the basis of an empirical study on hospital meal experiences explored...

  12. Protein Models Comparator

    CERN Document Server

    Widera, Paweł

    2011-01-01

    The process of comparison of computer generated protein structural models is an important element of protein structure prediction. It has many uses including model quality evaluation, selection of the final models from a large set of candidates or optimisation of parameters of energy functions used in template free modelling and refinement. Although many protein comparison methods are available online on numerous web servers, their ability to handle a large scale model comparison is often very limited. Most of the servers offer only a single pairwise structural comparison, and they usually do not provide a model-specific comparison with a fixed alignment between the models. To bridge the gap between the protein and model structure comparison we have developed the Protein Models Comparator (pm-cmp). To be able to deliver the scalability on demand and handle large comparison experiments the pm-cmp was implemented "in the cloud". Protein Models Comparator is a scalable web application for a fast distributed comp...

  13. Nonuniform Markov models

    CERN Document Server

    Ristad, E S; Ristad, Eric Sven; Thomas, Robert G.

    1996-01-01

    A statistical language model assigns probability to strings of arbitrary length. Unfortunately, it is not possible to gather reliable statistics on strings of arbitrary length from a finite corpus. Therefore, a statistical language model must decide that each symbol in a string depends on at most a small, finite number of other symbols in the string. In this report we propose a new way to model conditional independence in Markov models. The central feature of our nonuniform Markov model is that it makes predictions of varying lengths using contexts of varying lengths. Experiments on the Wall Street Journal reveal that the nonuniform model performs slightly better than the classic interpolated Markov model. This result is somewhat remarkable because both models contain identical numbers of parameters whose values are estimated in a similar manner. The only difference between the two models is how they combine the statistics of longer and shorter strings. Keywords: nonuniform Markov model, interpolated Markov m...

  14. Lumped Thermal Household Model

    DEFF Research Database (Denmark)

    Biegel, Benjamin; Andersen, Palle; Stoustrup, Jakob

    2013-01-01

    a lumped model approach as an alternative to the individual models. In the lumped model, the portfolio is seen as baseline consumption superimposed with an ideal storage of limited power and energy capacity. The benefit of such a lumped model is that the computational effort of flexibility optimization......In this paper we discuss two different approaches to model the flexible power consumption of heat pump heated households: individual household modeling and lumped modeling. We illustrate that a benefit of individual modeling is that we can overview and optimize the complete flexibility of a heat...... pump portfolio. Following, we illustrate two disadvantages of individual models, namely that it requires much computational effort to optimize over a large portfolio, and second that it is difficult to accurately model the houses in certain time periods due to local disturbances. Finally, we propose...

  15. Calibrated Properties Model

    Energy Technology Data Exchange (ETDEWEB)

    C. Ahlers; H. Liu

    2000-03-12

    The purpose of this Analysis/Model Report (AMR) is to document the Calibrated Properties Model that provides calibrated parameter sets for unsaturated zone (UZ) flow and transport process models for the Yucca Mountain Site Characterization Project (YMP). This work was performed in accordance with the ''AMR Development Plan for U0035 Calibrated Properties Model REV00. These calibrated property sets include matrix and fracture parameters for the UZ Flow and Transport Model (UZ Model), drift seepage models, drift-scale and mountain-scale coupled-processes models, and Total System Performance Assessment (TSPA) models as well as Performance Assessment (PA) and other participating national laboratories and government agencies. These process models provide the necessary framework to test conceptual hypotheses of flow and transport at different scales and predict flow and transport behavior under a variety of climatic and thermal-loading conditions.

  16. Introduction to Adjoint Models

    Science.gov (United States)

    Errico, Ronald M.

    2015-01-01

    In this lecture, some fundamentals of adjoint models will be described. This includes a basic derivation of tangent linear and corresponding adjoint models from a parent nonlinear model, the interpretation of adjoint-derived sensitivity fields, a description of methods of automatic differentiation, and the use of adjoint models to solve various optimization problems, including singular vectors. Concluding remarks will attempt to correct common misconceptions about adjoint models and their utilization.

  17. Modeling cholera outbreaks

    OpenAIRE

    Chao, Dennis L.; Ira M Longini; Morris, J. Glenn

    2014-01-01

    Mathematical modeling can be a valuable tool for studying infectious disease outbreak dynamics and simulating the effects of possible interventions. Here, we describe approaches to modeling cholera outbreaks and how models have been applied to explore intervention strategies, particularly in Haiti. Mathematical models can play an important role in formulating and evaluating complex cholera outbreak response options. Major challenges to cholera modeling are insufficient data for calibrating mo...

  18. Business Model Visualization

    OpenAIRE

    Zagorsek, Branislav

    2013-01-01

    Business model describes the company’s most important activities, proposed value, and the compensation for the value. Business model visualization enables to simply and systematically capture and describe the most important components of the business model while the standardization of the concept allows the comparison between companies. There are several possibilities how to visualize the model. The aim of this paper is to describe the options for business model visualization and business mod...

  19. Diffeomorphic Statistical Deformation Models

    DEFF Research Database (Denmark)

    Hansen, Michael Sass; Hansen, Mads/Fogtman; Larsen, Rasmus

    2007-01-01

    In this paper we present a new method for constructing diffeomorphic statistical deformation models in arbitrary dimensional images with a nonlinear generative model and a linear parameter space. Our deformation model is a modified version of the diffeomorphic model introduced by Cootes et al. Th...... with ground truth in form of manual expert annotations, and compared to Cootes's model. We anticipate applications in unconstrained diffeomorphic synthesis of images, e.g. for tracking, segmentation, registration or classification purposes....

  20. Dimension of linear models

    DEFF Research Database (Denmark)

    Høskuldsson, Agnar

    1996-01-01

    Determination of the proper dimension of a given linear model is one of the most important tasks in the applied modeling work. We consider here eight criteria that can be used to determine the dimension of the model, or equivalently, the number of components to use in the model. Four...... the basic problems in determining the dimension of linear models. Then each of the eight measures are treated. The results are illustrated by examples....

  1. Modeling cholera outbreaks

    OpenAIRE

    Dennis L Chao; Longini, Ira M.; Morris, J. Glenn

    2014-01-01

    Mathematical modeling can be a valuable tool for studying infectious disease outbreak dynamics and simulating the effects of possible interventions. Here, we describe approaches to modeling cholera outbreaks and how models have been applied to explore intervention strategies, particularly in Haiti. Mathematical models can play an important role in formulating and evaluating complex cholera outbreak response options. Major challenges to cholera modeling are insufficient data for calibrating mo...

  2. Multiple Model Approaches to Modelling and Control,

    DEFF Research Database (Denmark)

    Why Multiple Models?This book presents a variety of approaches which produce complex models or controllers by piecing together a number of simpler subsystems. Thisdivide-and-conquer strategy is a long-standing and general way of copingwith complexity in engineering systems, nature and human probl...

  3. Model Checking of Boolean Process Models

    CERN Document Server

    Schneider, Christoph

    2011-01-01

    In the field of Business Process Management formal models for the control flow of business processes have been designed since more than 15 years. Which methods are best suited to verify the bulk of these models? The first step is to select a formal language which fixes the semantics of the models. We adopt the language of Boolean systems as reference language for Boolean process models. Boolean systems form a simple subclass of coloured Petri nets. Their characteristics are low tokens to model explicitly states with a subsequent skipping of activations and arbitrary logical rules of type AND, XOR, OR etc. to model the split and join of the control flow. We apply model checking as a verification method for the safeness and liveness of Boolean systems. Model checking of Boolean systems uses the elementary theory of propositional logic, no modal operators are needed. Our verification builds on a finite complete prefix of a certain T-system attached to the Boolean system. It splits the processes of the Boolean sy...

  4. Pavement Aging Model by Response Surface Modeling

    Directory of Open Access Journals (Sweden)

    Manzano-Ramírez A.

    2011-10-01

    Full Text Available In this work, surface course aging was modeled by Response Surface Methodology (RSM. The Marshall specimens were placed in a conventional oven for time and temperature conditions established on the basis of the environment factors of the region where the surface course is constructed by AC-20 from the Ing. Antonio M. Amor refinery. Volatilized material (VM, load resistance increment (ΔL and flow resistance increment (ΔF models were developed by the RSM. Cylindrical specimens with real aging were extracted from the surface course pilot to evaluate the error of the models. The VM model was adequate, in contrast (ΔL and (ΔF models were almost adequate with an error of 20 %, that was associated with the other environmental factors, which were not considered at the beginning of the research.

  5. Model Validation Status Review

    Energy Technology Data Exchange (ETDEWEB)

    E.L. Hardin

    2001-11-28

    The primary objective for the Model Validation Status Review was to perform a one-time evaluation of model validation associated with the analysis/model reports (AMRs) containing model input to total-system performance assessment (TSPA) for the Yucca Mountain site recommendation (SR). This review was performed in response to Corrective Action Request BSC-01-C-01 (Clark 2001, Krisha 2001) pursuant to Quality Assurance review findings of an adverse trend in model validation deficiency. The review findings in this report provide the following information which defines the extent of model validation deficiency and the corrective action needed: (1) AMRs that contain or support models are identified, and conversely, for each model the supporting documentation is identified. (2) The use for each model is determined based on whether the output is used directly for TSPA-SR, or for screening (exclusion) of features, events, and processes (FEPs), and the nature of the model output. (3) Two approaches are used to evaluate the extent to which the validation for each model is compliant with AP-3.10Q (Analyses and Models). The approaches differ in regard to whether model validation is achieved within individual AMRs as originally intended, or whether model validation could be readily achieved by incorporating information from other sources. (4) Recommendations are presented for changes to the AMRs, and additional model development activities or data collection, that will remedy model validation review findings, in support of licensing activities. The Model Validation Status Review emphasized those AMRs that support TSPA-SR (CRWMS M&O 2000bl and 2000bm). A series of workshops and teleconferences was held to discuss and integrate the review findings. The review encompassed 125 AMRs (Table 1) plus certain other supporting documents and data needed to assess model validity. The AMRs were grouped in 21 model areas representing the modeling of processes affecting the natural and

  6. Product and Process Modelling

    DEFF Research Database (Denmark)

    Cameron, Ian T.; Gani, Rafiqul

    This book covers the area of product and process modelling via a case study approach. It addresses a wide range of modelling applications with emphasis on modelling methodology and the subsequent in-depth analysis of mathematical models to gain insight via structural aspects of the models....... These approaches are put into the context of life cycle modelling, where multiscale and multiform modelling is increasingly prevalent in the 21st century. The book commences with a discussion of modern product and process modelling theory and practice followed by a series of case studies drawn from a variety...... to biotechnology applications, food, polymer and human health application areas. The book highlights to important nature of modern product and process modelling in the decision making processes across the life cycle. As such it provides an important resource for students, researchers and industrial practitioners....

  7. Practical Marginalized Multilevel Models.

    Science.gov (United States)

    Griswold, Michael E; Swihart, Bruce J; Caffo, Brian S; Zeger, Scott L

    2013-01-01

    Clustered data analysis is characterized by the need to describe both systematic variation in a mean model and cluster-dependent random variation in an association model. Marginalized multilevel models embrace the robustness and interpretations of a marginal mean model, while retaining the likelihood inference capabilities and flexible dependence structures of a conditional association model. Although there has been increasing recognition of the attractiveness of marginalized multilevel models, there has been a gap in their practical application arising from a lack of readily available estimation procedures. We extend the marginalized multilevel model to allow for nonlinear functions in both the mean and association aspects. We then formulate marginal models through conditional specifications to facilitate estimation with mixed model computational solutions already in place. We illustrate the MMM and approximate MMM approaches on a cerebrovascular deficiency crossover trial using SAS and an epidemiological study on race and visual impairment using R. Datasets, SAS and R code are included as supplemental materials.

  8. Numerical simulation of lowest-order short-crested wave instabilities

    DEFF Research Database (Denmark)

    Fuhrman, David R.; Madsen, Per A.; Bingham, Harry

    2006-01-01

    A numerical study of doubly periodic deep-water short-crested wave instabilities, arising from various quartet resonant interactions, is conducted using a high-order Boussinesq-type model. The model is first verified through a series of simulations involving classical class I plane wave...... demonstrates a reasonably similar evolution. These simulations consider the simplest physical situations involving three-dimensional instabilities of genuinely three-dimensional progressive waves, revealing qualitative differences from classical two-dimensional descriptions. This study is therefore...

  9. Modelling Foundations and Applications

    DEFF Research Database (Denmark)

    This book constitutes the refereed proceedings of the 8th European Conference on Modelling Foundations and Applications, held in Kgs. Lyngby, Denmark, in July 2012. The 20 revised full foundations track papers and 10 revised full applications track papers presented were carefully reviewed...... and selected from 81 submissions. Papers on all aspects of MDE were received, including topics such as architectural modelling and product lines, code generation, domain-specic modeling, metamodeling, model analysis and verication, model management, model transformation and simulation. The breadth of topics...

  10. On Communication Models

    Institute of Scientific and Technical Information of China (English)

    蒋娜; 谢有琪

    2012-01-01

    With the development of human society, the social hub enlarges beyond one community to the extent that the world is deemed as a community as a whole. Communication, therefore, plays an increasingly important role in our daily life. As a consequence, communication model or the definition of which is not so much a definition as a guide in communication. However, some existed communication models are not as practical as it was. This paper tries to make an overall contrast among three communication models Coded Model, Gable Communication Model and Ostensive Inferential Model, to see how they assist people to comprehend verbal and non -verbal communication.

  11. Modeling worldwide highway networks

    Science.gov (United States)

    Villas Boas, Paulino R.; Rodrigues, Francisco A.; da F. Costa, Luciano

    2009-12-01

    This Letter addresses the problem of modeling the highway systems of different countries by using complex networks formalism. More specifically, we compare two traditional geographical models with a modified geometrical network model where paths, rather than edges, are incorporated at each step between the origin and the destination vertices. Optimal configurations of parameters are obtained for each model and used for the comparison. The highway networks of Australia, Brazil, India, and Romania are considered and shown to be properly modeled by the modified geographical model.

  12. THE IMPROVED XINANJIANG MODEL

    Institute of Scientific and Technical Information of China (English)

    LI Zhi-jia; YAO Cheng; KONG Xiang-guang

    2005-01-01

    To improve the Xinanjiang model, the runoff generating from infiltration-excess is added to the model.The another 6 parameters are added to Xinanjiang model.In principle, the improved Xinanjiang model can be used to simulate runoff in the humid, semi-humid and also semi-arid regions.The application in Yi River shows the improved Xinanjiang model could forecast discharge with higher accuracy and can satisfy the practical requirements.It also shows that the improved model is reasonable.

  13. Microsoft tabular modeling cookbook

    CERN Document Server

    Braak, Paul te

    2013-01-01

    This book follows a cookbook style with recipes explaining the steps for developing analytic data using Business Intelligence Semantic Models.This book is designed for developers who wish to develop powerful and dynamic models for users as well as those who are responsible for the administration of models in corporate environments. It is also targeted at analysts and users of Excel who wish to advance their knowledge of Excel through the development of tabular models or who wish to analyze data through tabular modeling techniques. We assume no prior knowledge of tabular modeling

  14. Five models of capitalism

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Bresser-Pereira

    2012-03-01

    Full Text Available Besides analyzing capitalist societies historically and thinking of them in terms of phases or stages, we may compare different models or varieties of capitalism. In this paper I survey the literature on this subject, and distinguish the classification that has a production or business approach from those that use a mainly political criterion. I identify five forms of capitalism: among the rich countries, the liberal democratic or Anglo-Saxon model, the social or European model, and the endogenous social integration or Japanese model; among developing countries, I distinguish the Asian developmental model from the liberal-dependent model that characterizes most other developing countries, including Brazil.

  15. Holographic twin Higgs model.

    Science.gov (United States)

    Geller, Michael; Telem, Ofri

    2015-05-15

    We present the first realization of a "twin Higgs" model as a holographic composite Higgs model. Uniquely among composite Higgs models, the Higgs potential is protected by a new standard model (SM) singlet elementary "mirror" sector at the sigma model scale f and not by the composite states at m_{KK}, naturally allowing for m_{KK} beyond the LHC reach. As a result, naturalness in our model cannot be constrained by the LHC, but may be probed by precision Higgs measurements at future lepton colliders, and by direct searches for Kaluza-Klein excitations at a 100 TeV collider.

  16. Energy-consumption modelling

    Energy Technology Data Exchange (ETDEWEB)

    Reiter, E.R.

    1980-01-01

    A highly sophisticated and accurate approach is described to compute on an hourly or daily basis the energy consumption for space heating by individual buildings, urban sectors, and whole cities. The need for models and specifically weather-sensitive models, composite models, and space-heating models are discussed. Development of the Colorado State University Model, based on heat-transfer equations and on a heuristic, adaptive, self-organizing computation learning approach, is described. Results of modeling energy consumption by the city of Minneapolis and Cheyenne are given. Some data on energy consumption in individual buildings are included.

  17. Empirical Model Building Data, Models, and Reality

    CERN Document Server

    Thompson, James R

    2011-01-01

    Praise for the First Edition "This...novel and highly stimulating book, which emphasizes solving real problems...should be widely read. It will have a positive and lasting effect on the teaching of modeling and statistics in general." - Short Book Reviews This new edition features developments and real-world examples that showcase essential empirical modeling techniques Successful empirical model building is founded on the relationship between data and approximate representations of the real systems that generated that data. As a result, it is essential for researchers who construct these m

  18. Develop a Model Component

    Science.gov (United States)

    Ensey, Tyler S.

    2013-01-01

    During my internship at NASA, I was a model developer for Ground Support Equipment (GSE). The purpose of a model developer is to develop and unit test model component libraries (fluid, electrical, gas, etc.). The models are designed to simulate software for GSE (Ground Special Power, Crew Access Arm, Cryo, Fire and Leak Detection System, Environmental Control System (ECS), etc. .) before they are implemented into hardware. These models support verifying local control and remote software for End-Item Software Under Test (SUT). The model simulates the physical behavior (function, state, limits and 110) of each end-item and it's dependencies as defined in the Subsystem Interface Table, Software Requirements & Design Specification (SRDS), Ground Integrated Schematic (GIS), and System Mechanical Schematic.(SMS). The software of each specific model component is simulated through MATLAB's Simulink program. The intensiv model development life cycle is a.s follows: Identify source documents; identify model scope; update schedule; preliminary design review; develop model requirements; update model.. scope; update schedule; detailed design review; create/modify library component; implement library components reference; implement subsystem components; develop a test script; run the test script; develop users guide; send model out for peer review; the model is sent out for verifictionlvalidation; if there is empirical data, a validation data package is generated; if there is not empirical data, a verification package is generated; the test results are then reviewed; and finally, the user. requests accreditation, and a statement of accreditation is prepared. Once each component model is reviewed and approved, they are intertwined together into one integrated model. This integrated model is then tested itself, through a test script and autotest, so that it can be concluded that all models work conjointly, for a single purpose. The component I was assigned, specifically, was a

  19. Biosphere Model Report

    Energy Technology Data Exchange (ETDEWEB)

    D.W. Wu; A.J. Smith

    2004-11-08

    The purpose of this report is to document the biosphere model, the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), which describes radionuclide transport processes in the biosphere and associated human exposure that may arise as the result of radionuclide release from the geologic repository at Yucca Mountain. The biosphere model is one of the process models that support the Yucca Mountain Project (YMP) Total System Performance Assessment (TSPA) for the license application (LA), TSPA-LA. The ERMYN provides the capability of performing human radiation dose assessments. This report documents the biosphere model, which includes: (1) Describing the reference biosphere, human receptor, exposure scenarios, and primary radionuclides for each exposure scenario (Section 6.1); (2) Developing a biosphere conceptual model using site-specific features, events, and processes (FEPs) (Section 6.2), the reference biosphere (Section 6.1.1), the human receptor (Section 6.1.2), and approximations (Sections 6.3.1.4 and 6.3.2.4); (3) Building a mathematical model using the biosphere conceptual model (Section 6.3) and published biosphere models (Sections 6.4 and 6.5); (4) Summarizing input parameters for the mathematical model, including the uncertainty associated with input values (Section 6.6); (5) Identifying improvements in the ERMYN compared with the model used in previous biosphere modeling (Section 6.7); (6) Constructing an ERMYN implementation tool (model) based on the biosphere mathematical model using GoldSim stochastic simulation software (Sections 6.8 and 6.9); (7) Verifying the ERMYN by comparing output from the software with hand calculations to ensure that the GoldSim implementation is correct (Section 6.10); (8) Validating the ERMYN by corroborating it with published biosphere models; comparing conceptual models, mathematical models, and numerical results (Section 7).

  20. Major Differences between the Jerome Model and the Horace Model

    Institute of Scientific and Technical Information of China (English)

    朱艳

    2014-01-01

    There are three famous translation models in the field of translation: the Jerome model, the Horace model and the Schleiermacher model. The production and development of the three models have significant influence on the translation. To find the major differences between the two western classical translation theoretical models, we discuss the Jerome model and the Hor-ace model deeply in this paper.

  1. Modelling cointegration in the vector autoregressive model

    DEFF Research Database (Denmark)

    Johansen, Søren

    2000-01-01

    A survey is given of some results obtained for the cointegrated VAR. The Granger representation theorem is discussed and the notions of cointegration and common trends are defined. The statistical model for cointegrated I(1) variables is defined, and it is shown how hypotheses on the cointegrating...... relations can be estimated under suitable identification conditions. The asymptotic theory is briefly mentioned and a few economic applications of the cointegration model are indicated....

  2. Emissions Modeling Clearinghouse

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Emissions Modeling Clearinghouse (EMCH) supports and promotes emissions modeling activities both internal and external to the EPA. Through this site, the EPA...

  3. ASC Champ Orbit Model

    DEFF Research Database (Denmark)

    Riis, Troels; Jørgensen, John Leif

    1999-01-01

    This documents describes a test of the implementation of the ASC orbit model for the Champ satellite.......This documents describes a test of the implementation of the ASC orbit model for the Champ satellite....

  4. World Magnetic Model 2015

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The World Magnetic Model is the standard model used by the U.S. Department of Defense, the U.K. Ministry of Defence, the North Atlantic Treaty Organization (NATO)...

  5. Laboratory of Biological Modeling

    Data.gov (United States)

    Federal Laboratory Consortium — The Laboratory of Biological Modeling is defined by both its methodologies and its areas of application. We use mathematical modeling in many forms and apply it to...

  6. Model comparison in ANOVA.

    Science.gov (United States)

    Rouder, Jeffrey N; Engelhardt, Christopher R; McCabe, Simon; Morey, Richard D

    2016-12-01

    Analysis of variance (ANOVA), the workhorse analysis of experimental designs, consists of F-tests of main effects and interactions. Yet, testing, including traditional ANOVA, has been recently critiqued on a number of theoretical and practical grounds. In light of these critiques, model comparison and model selection serve as an attractive alternative. Model comparison differs from testing in that one can support a null or nested model vis-a-vis a more general alternative by penalizing more flexible models. We argue this ability to support more simple models allows for more nuanced theoretical conclusions than provided by traditional ANOVA F-tests. We provide a model comparison strategy and show how ANOVA models may be reparameterized to better address substantive questions in data analysis.

  7. Graphical Models with R

    DEFF Research Database (Denmark)

    Højsgaard, Søren; Edwards, David; Lauritzen, Steffen

    Graphical models in their modern form have been around since the late 1970s and appear today in many areas of the sciences. Along with the ongoing developments of graphical models, a number of different graphical modeling software programs have been written over the years. In recent years many...... of these software developments have taken place within the R community, either in the form of new packages or by providing an R ingerface to existing software. This book attempts to give the reader a gentle introduction to graphical modeling using R and the main features of some of these packages. In addition......, the book provides examples of how more advanced aspects of graphical modeling can be represented and handled within R. Topics covered in the seven chapters include graphical models for contingency tables, Gaussian and mixed graphical models, Bayesian networks and modeling high dimensional data...

  8. Controlling Modelling Artifacts

    DEFF Research Database (Denmark)

    Smith, Michael James Andrew; Nielson, Flemming; Nielson, Hanne Riis

    2011-01-01

    the possible configurations of the system (for example, by counting the number of components in a certain state). We motivate our methodology with a case study of the LMAC protocol for wireless sensor networks. In particular, we investigate the accuracy of a recently proposed high-level model of LMAC......When analysing the performance of a complex system, we typically build abstract models that are small enough to analyse, but still capture the relevant details of the system. But it is difficult to know whether the model accurately describes the real system, or if its behaviour is due to modelling...... artifacts that were inadvertently introduced. In this paper, we propose a novel methodology to reason about modelling artifacts, given a detailed model and a highlevel (more abstract) model of the same system. By a series of automated abstraction steps, we lift the detailed model to the same state space...

  9. Laboratory of Biological Modeling

    Data.gov (United States)

    Federal Laboratory Consortium — The Laboratory of Biological Modeling is defined by both its methodologies and its areas of application. We use mathematical modeling in many forms and apply it to a...

  10. Modeling EERE deployment programs

    Energy Technology Data Exchange (ETDEWEB)

    Cort, K. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hostick, D. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Belzer, D. B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Livingston, O. V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2007-11-01

    The purpose of the project was to identify and characterize the modeling of deployment programs within the EERE Technology Development (TD) programs, address possible improvements to the modeling process, and note gaps in knowledge for future research.

  11. Consistent model driven architecture

    Science.gov (United States)

    Niepostyn, Stanisław J.

    2015-09-01

    The goal of the MDA is to produce software systems from abstract models in a way where human interaction is restricted to a minimum. These abstract models are based on the UML language. However, the semantics of UML models is defined in a natural language. Subsequently the verification of consistency of these diagrams is needed in order to identify errors in requirements at the early stage of the development process. The verification of consistency is difficult due to a semi-formal nature of UML diagrams. We propose automatic verification of consistency of the series of UML diagrams originating from abstract models implemented with our consistency rules. This Consistent Model Driven Architecture approach enables us to generate automatically complete workflow applications from consistent and complete models developed from abstract models (e.g. Business Context Diagram). Therefore, our method can be used to check practicability (feasibility) of software architecture models.

  12. Bounding species distribution models

    Directory of Open Access Journals (Sweden)

    Thomas J. STOHLGREN, Catherine S. JARNEVICH, Wayne E. ESAIAS,Jeffrey T. MORISETTE

    2011-10-01

    Full Text Available Species distribution models are increasing in popularity for mapping suitable habitat for species of management concern. Many investigators now recognize that extrapolations of these models with geographic information systems (GIS might be sensitive to the environmental bounds of the data used in their development, yet there is no recommended best practice for “clamping” model extrapolations. We relied on two commonly used modeling approaches: classification and regression tree (CART and maximum entropy (Maxent models, and we tested a simple alteration of the model extrapolations, bounding extrapolations to the maximum and minimum values of primary environmental predictors, to provide a more realistic map of suitable habitat of hybridized Africanized honey bees in the southwestern United States. Findings suggest that multiple models of bounding, and the most conservative bounding of species distribution models, like those presented here, should probably replace the unbounded or loosely bounded techniques currently used [Current Zoology 57 (5: 642–647, 2011].

  13. CCF model comparison

    Energy Technology Data Exchange (ETDEWEB)

    Pulkkinen, U. [VTT Industrial Systems (Finland)

    2004-04-01

    The report describes a simple comparison of two CCF-models, the ECLM, and the Beta-model. The objective of the comparison is to identify differences in the results of the models by applying the models in some simple test data cases. The comparison focuses mainly on theoretical aspects of the above mentioned CCF-models. The properties of the model parameter estimates in the data cases is also discussed. The practical aspects in using and estimating CCFmodels in real PSA context (e.g. the data interpretation, properties of computer tools, the model documentation) are not discussed in the report. Similarly, the qualitative CCF-analyses needed in using the models are not discussed in the report. (au)

  14. Chip Multithreaded Consistency Model

    Institute of Scientific and Technical Information of China (English)

    Zu-Song Li; Dan-Dan Huan; Wei-Wu Hu; Zhi-Min Tang

    2008-01-01

    Multithreaded technique is the developing trend of high performance processor. Memory consistency model is essential to the correctness, performance and complexity of multithreaded processor. The chip multithreaded consistency model adapting to multithreaded processor is proposed in this paper. The restriction imposed on memory event ordering by chip multithreaded consistency is presented and formalized. With the idea of critical cycle built by Wei-Wu Hu, we prove that the proposed chip multithreaded consistency model satisfies the criterion of correct execution of sequential consistency model. Chip multithreaded consistency model provides a way of achieving high performance compared with sequential consistency model and ensures the compatibility of software that the execution result in multithreaded processor is the same as the execution result in uniprocessor. The implementation strategy of chip multithreaded consistency model in Godson-2 SMT processor is also proposed. Godson-2 SMT processor supports chip multithreaded consistency model correctly by exception scheme based on the sequential memory access queue of each thread.

  15. Models (Part 1).

    Science.gov (United States)

    Callison, Daniel

    2002-01-01

    Defines models and describes information search models that can be helpful to instructional media specialists in meeting users' abilities and information needs. Explains pathfinders and Kuhlthau's information search process, including the pre-writing information search process. (LRW)

  16. Modeling DNA Replication.

    Science.gov (United States)

    Bennett, Joan

    1998-01-01

    Recommends the use of a model of DNA made out of Velcro to help students visualize the steps of DNA replication. Includes a materials list, construction directions, and details of the demonstration using the model parts. (DDR)

  17. Modeling Complex Time Limits

    Directory of Open Access Journals (Sweden)

    Oleg Svatos

    2013-01-01

    Full Text Available In this paper we analyze complexity of time limits we can find especially in regulated processes of public administration. First we review the most popular process modeling languages. There is defined an example scenario based on the current Czech legislature which is then captured in discussed process modeling languages. Analysis shows that the contemporary process modeling languages support capturing of the time limit only partially. This causes troubles to analysts and unnecessary complexity of the models. Upon unsatisfying results of the contemporary process modeling languages we analyze the complexity of the time limits in greater detail and outline lifecycles of a time limit using the multiple dynamic generalizations pattern. As an alternative to the popular process modeling languages there is presented PSD process modeling language, which supports the defined lifecycles of a time limit natively and therefore allows keeping the models simple and easy to understand.

  18. World Magnetic Model 2010

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The World Magnetic Model is the standard model used by the U.S. Department of Defense, the U.K. Ministry of Defence, the North Atlantic Treaty Organization (NATO)...

  19. Bounding Species Distribution Models

    Science.gov (United States)

    Stohlgren, Thomas J.; Jarnevich, Cahterine S.; Morisette, Jeffrey T.; Esaias, Wayne E.

    2011-01-01

    Species distribution models are increasing in popularity for mapping suitable habitat for species of management concern. Many investigators now recognize that extrapolations of these models with geographic information systems (GIS) might be sensitive to the environmental bounds of the data used in their development, yet there is no recommended best practice for "clamping" model extrapolations. We relied on two commonly used modeling approaches: classification and regression tree (CART) and maximum entropy (Maxent) models, and we tested a simple alteration of the model extrapolations, bounding extrapolations to the maximum and minimum values of primary environmental predictors, to provide a more realistic map of suitable habitat of hybridized Africanized honey bees in the southwestern United States. Findings suggest that multiple models of bounding, and the most conservative bounding of species distribution models, like those presented here, should probably replace the unbounded or loosely bounded techniques currently used [Current Zoology 57 (5): 642-647, 2011].

  20. The ATLAS Analysis Model

    CERN Multimedia

    Amir Farbin

    The ATLAS Analysis Model is a continually developing vision of how to reconcile physics analysis requirements with the ATLAS offline software and computing model constraints. In the past year this vision has influenced the evolution of the ATLAS Event Data Model, the Athena software framework, and physics analysis tools. These developments, along with the October Analysis Model Workshop and the planning for CSC analyses have led to a rapid refinement of the ATLAS Analysis Model in the past few months. This article introduces some of the relevant issues and presents the current vision of the future ATLAS Analysis Model. Event Data Model The ATLAS Event Data Model (EDM) consists of several levels of details, each targeted for a specific set of tasks. For example the Event Summary Data (ESD) stores calorimeter cells and tracking system hits thereby permitting many calibration and alignment tasks, but will be only accessible at particular computing sites with potentially large latency. In contrast, the Analysis...

  1. LAT Background Models

    Data.gov (United States)

    National Aeronautics and Space Administration — The Galactic model is a spatial and spectral template. The model for the Galactic diffuse emission was developed using spectral line surveys of HI and CO (as a...

  2. Photovoltaic sources modeling

    CERN Document Server

    Petrone, Giovanni; Spagnuolo, Giovanni

    2016-01-01

    This comprehensive guide surveys all available models for simulating a photovoltaic (PV) generator at different levels of granularity, from cell to system level, in uniform as well as in mismatched conditions. Providing a thorough comparison among the models, engineers have all the elements needed to choose the right PV array model for specific applications or environmental conditions matched with the model of the electronic circuit used to maximize the PV power production.

  3. Toric models of graphs

    CERN Document Server

    Buczyńska, Weronika

    2010-01-01

    We define toric projective model of a trivalent graph as a generalization of a binary symmetric model of a trivalent phylogenetic tree. Generators of the projective coordinate ring of the models of graphs with one cycle are explicitly described. The models of graphs with the same topological invariants are deformation equivalent and share the same Hilbert function. We also provide an algorithm to compute the Hilbert function.

  4. Model of magnetostrictive actuator

    Institute of Scientific and Technical Information of China (English)

    LI Lin; ZHANG Yuan-yuan

    2005-01-01

    The hysteresis of the magnetostrictive actuator was studied. A mathematical model of the hysteresis loop was obtained on the basis of experiment. This model depends on the frequency and the amplitude of the alternating current inputted to the magnetostrictive actuator. Based on the model, the effect of hysteresis on dynamic output of the magnetostrictive actuator was investigated. Then how to consider hysteresis and establish a dynamic model of a magnetostrictive actuator system is discussed when a practical system was designed and applied.

  5. GIS Conceptual Data Model

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In order to set up a conceptual data model that reflects the real world as accurately as possible,this paper firstly reviews and analyzes the disadvantages of previous conceptual data models used by traditional GIS in simulating geographic space,gives a new explanation to geographic space and analyzes its various essential characteristics.Finally,this paper proposes several detailed key points for designing a new type of GIS data model and gives a simple holistic GIS data model.

  6. Modeling Digital Video Database

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The main purpose of the model is to present how the UnifiedModeling L anguage (UML) can be used for modeling digital video database system (VDBS). It demonstrates the modeling process that can be followed during the analysis phase of complex applications. In order to guarantee the continuity mapping of the mo dels, the authors propose some suggestions to transform the use case diagrams in to an object diagram, which is one of the main diagrams for the next development phases.

  7. Hierarchical Bass model

    Science.gov (United States)

    Tashiro, Tohru

    2014-03-01

    We propose a new model about diffusion of a product which includes a memory of how many adopters or advertisements a non-adopter met, where (non-)adopters mean people (not) possessing the product. This effect is lacking in the Bass model. As an application, we utilize the model to fit the iPod sales data, and so the better agreement is obtained than the Bass model.

  8. Quantal Response: Nonparametric Modeling

    Science.gov (United States)

    2017-01-01

    spline N−spline Fig. 3 Logistic regression 7 Approved for public release; distribution is unlimited. 5. Nonparametric QR Models Nonparametric linear ...stimulus and probability of response. The Generalized Linear Model approach does not make use of the limit distribution but allows arbitrary functional...7. Conclusions and Recommendations 18 8. References 19 Appendix A. The Linear Model 21 Appendix B. The Generalized Linear Model 33 Appendix C. B

  9. Auxiliary Deep Generative Models

    OpenAIRE

    Maaløe, Lars; Sønderby, Casper Kaae; Sønderby, Søren Kaae; Winther, Ole

    2016-01-01

    Deep generative models parameterized by neural networks have recently achieved state-of-the-art performance in unsupervised and semi-supervised learning. We extend deep generative models with auxiliary variables which improves the variational approximation. The auxiliary variables leave the generative model unchanged but make the variational distribution more expressive. Inspired by the structure of the auxiliary variable we also propose a model with two stochastic layers and skip connections...

  10. Avionics Architecture Modelling Language

    Science.gov (United States)

    Alana, Elena; Naranjo, Hector; Valencia, Raul; Medina, Alberto; Honvault, Christophe; Rugina, Ana; Panunzia, Marco; Dellandrea, Brice; Garcia, Gerald

    2014-08-01

    This paper presents the ESA AAML (Avionics Architecture Modelling Language) study, which aimed at advancing the avionics engineering practices towards a model-based approach by (i) identifying and prioritising the avionics-relevant analyses, (ii) specifying the modelling language features necessary to support the identified analyses, and (iii) recommending/prototyping software tooling to demonstrate the automation of the selected analyses based on a modelling language and compliant with the defined specification.

  11. Hierarchical Bass model

    CERN Document Server

    Tashiro, Tohru

    2013-01-01

    We propose a new model about diffusion of a product which includes a memory of how many adopters or advertisements a non-adopter met, where (non-)adopters mean people (not) possessing the product. This effect is lacking in the Bass model. As an application, we utilize the model to fit the iPod sales data, and so the better agreement is obtained than the Bass model.

  12. Artificial neural network modelling

    CERN Document Server

    Samarasinghe, Sandhya

    2016-01-01

    This book covers theoretical aspects as well as recent innovative applications of Artificial Neural networks (ANNs) in natural, environmental, biological, social, industrial and automated systems. It presents recent results of ANNs in modelling small, large and complex systems under three categories, namely, 1) Networks, Structure Optimisation, Robustness and Stochasticity 2) Advances in Modelling Biological and Environmental Systems and 3) Advances in Modelling Social and Economic Systems. The book aims at serving undergraduates, postgraduates and researchers in ANN computational modelling. .

  13. Optimization modeling with spreadsheets

    CERN Document Server

    Baker, Kenneth R

    2015-01-01

    An accessible introduction to optimization analysis using spreadsheets Updated and revised, Optimization Modeling with Spreadsheets, Third Edition emphasizes model building skills in optimization analysis. By emphasizing both spreadsheet modeling and optimization tools in the freely available Microsoft® Office Excel® Solver, the book illustrates how to find solutions to real-world optimization problems without needing additional specialized software. The Third Edition includes many practical applications of optimization models as well as a systematic framework that il

  14. Model Checking Feature Interactions

    DEFF Research Database (Denmark)

    Le Guilly, Thibaut; Olsen, Petur; Pedersen, Thomas;

    2015-01-01

    This paper presents an offline approach to analyzing feature interactions in embedded systems. The approach consists of a systematic process to gather the necessary information about system components and their models. The model is first specified in terms of predicates, before being refined to t...... to timed automata. The consistency of the model is verified at different development stages, and the correct linkage between the predicates and their semantic model is checked. The approach is illustrated on a use case from home automation....

  15. GARCH Modelling of Cryptocurrencies

    Directory of Open Access Journals (Sweden)

    Jeffrey Chu

    2017-10-01

    Full Text Available With the exception of Bitcoin, there appears to be little or no literature on GARCH modelling of cryptocurrencies. This paper provides the first GARCH modelling of the seven most popular cryptocurrencies. Twelve GARCH models are fitted to each cryptocurrency, and their fits are assessed in terms of five criteria. Conclusions are drawn on the best fitting models, forecasts and acceptability of value at risk estimates.

  16. Modelling of Corrosion Cracks

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    Modelling of corrosion cracking of reinforced concrete structures is complicated as a great number of uncertain factors are involved. To get a reliable modelling a physical and mechanical understanding of the process behind corrosion in needed.......Modelling of corrosion cracking of reinforced concrete structures is complicated as a great number of uncertain factors are involved. To get a reliable modelling a physical and mechanical understanding of the process behind corrosion in needed....

  17. Modeling and Remodeling Writing

    Science.gov (United States)

    Hayes, John R.

    2012-01-01

    In Section 1 of this article, the author discusses the succession of models of adult writing that he and his colleagues have proposed from 1980 to the present. He notes the most important changes that differentiate earlier and later models and discusses reasons for the changes. In Section 2, he describes his recent efforts to model young…

  18. Climate models and scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Fortelius, C.; Holopainen, E.; Kaurola, J.; Ruosteenoja, K.; Raeisaenen, J. [Helsinki Univ. (Finland). Dept. of Meteorology

    1996-12-31

    In recent years the modelling of interannual climate variability has been studied, the atmospheric energy and water cycles, and climate simulations with the ECHAM3 model. In addition, the climate simulations of several models have been compared with special emphasis in the area of northern Europe

  19. Crushed Salt Constitutive Model

    Energy Technology Data Exchange (ETDEWEB)

    Callahan, G.D.

    1999-02-01

    The constitutive model used to describe the deformation of crushed salt is presented in this report. Two mechanisms -- dislocation creep and grain boundary diffusional pressure solution -- are combined to form the basis for the constitutive model governing the deformation of crushed salt. The constitutive model is generalized to represent three-dimensional states of stress. Upon complete consolidation, the crushed-salt model reproduces the Multimechanism Deformation (M-D) model typically used for the Waste Isolation Pilot Plant (WIPP) host geological formation salt. New shear consolidation tests are combined with an existing database that includes hydrostatic consolidation and shear consolidation tests conducted on WIPP and southeastern New Mexico salt. Nonlinear least-squares model fitting to the database produced two sets of material parameter values for the model -- one for the shear consolidation tests and one for a combination of the shear and hydrostatic consolidation tests. Using the parameter values determined from the fitted database, the constitutive model is validated against constant strain-rate tests. Shaft seal problems are analyzed to demonstrate model-predicted consolidation of the shaft seal crushed-salt component. Based on the fitting statistics, the ability of the model to predict the test data, and the ability of the model to predict load paths and test data outside of the fitted database, the model appears to capture the creep consolidation behavior of crushed salt reasonably well.

  20. Modeling EERE Deployment Programs

    Energy Technology Data Exchange (ETDEWEB)

    Cort, K. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hostick, D. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Belzer, D. B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Livingston, O. V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2007-11-01

    This report compiles information and conclusions gathered as part of the “Modeling EERE Deployment Programs” project. The purpose of the project was to identify and characterize the modeling of deployment programs within the EERE Technology Development (TD) programs, address possible improvements to the modeling process, and note gaps in knowledge in which future research is needed.

  1. Modelling Vocabulary Loss

    Science.gov (United States)

    Meara, Paul

    2004-01-01

    This paper describes some simple simulation models of vocabulary attrition. The attrition process is modelled using a random autonomous Boolean network model, and some parallels with real attrition data are drawn. The paper argues that applying a complex systems approach to attrition can provide some important insights, which suggest that real…

  2. Flexible survival regression modelling

    DEFF Research Database (Denmark)

    Cortese, Giuliana; Scheike, Thomas H; Martinussen, Torben

    2009-01-01

    Regression analysis of survival data, and more generally event history data, is typically based on Cox's regression model. We here review some recent methodology, focusing on the limitations of Cox's regression model. The key limitation is that the model is not well suited to represent time-varyi...

  3. Scalability of human models

    NARCIS (Netherlands)

    Rodarius, C.; Rooij, L. van; Lange, R. de

    2007-01-01

    The objective of this work was to create a scalable human occupant model that allows adaptation of human models with respect to size, weight and several mechanical parameters. Therefore, for the first time two scalable facet human models were developed in MADYMO. First, a scalable human male was

  4. Modeling typical performance measures

    NARCIS (Netherlands)

    Weekers, Anke Martine

    2009-01-01

    In the educational, employment, and clinical context, attitude and personality inventories are used to measure typical performance traits. Statistical models are applied to obtain latent trait estimates. Often the same statistical models as the models used in maximum performance measurement are appl

  5. Model-based geostatistics

    CERN Document Server

    Diggle, Peter J

    2007-01-01

    Model-based geostatistics refers to the application of general statistical principles of modeling and inference to geostatistical problems. This volume provides a treatment of model-based geostatistics and emphasizes on statistical methods and applications. It also features analyses of datasets from a range of scientific contexts.

  6. Zephyr - the prediction models

    DEFF Research Database (Denmark)

    Nielsen, Torben Skov; Madsen, Henrik; Nielsen, Henrik Aalborg

    2001-01-01

    This paper briefly describes new models and methods for predicationg the wind power output from wind farms. The system is being developed in a project which has the research organization Risø and the department of Informatics and Mathematical Modelling (IMM) as the modelling team and all the Dani...

  7. Model Breaking Points Conceptualized

    Science.gov (United States)

    Vig, Rozy; Murray, Eileen; Star, Jon R.

    2014-01-01

    Current curriculum initiatives (e.g., National Governors Association Center for Best Practices and Council of Chief State School Officers 2010) advocate that models be used in the mathematics classroom. However, despite their apparent promise, there comes a point when models break, a point in the mathematical problem space where the model cannot,…

  8. Generalized Poisson sigma models

    CERN Document Server

    Batalin, I; Batalin, Igor; Marnelius, Robert

    2001-01-01

    A general master action in terms of superfields is given which generates generalized Poisson sigma models by means of a natural ghost number prescription. The simplest representation is the sigma model considered by Cattaneo and Felder. For Dirac brackets considerably more general models are generated.

  9. Modern Media Education Models

    Science.gov (United States)

    Fedorov, Alexander

    2011-01-01

    The author supposed that media education models can be divided into the following groups: (1) educational-information models (the study of the theory, history, language of media culture, etc.), based on the cultural, aesthetic, semiotic, socio-cultural theories of media education; (2) educational-ethical models (the study of moral, religions,…

  10. Models for Products

    Science.gov (United States)

    Speiser, Bob; Walter, Chuck

    2011-01-01

    This paper explores how models can support productive thinking. For us a model is a "thing", a tool to help make sense of something. We restrict attention to specific models for whole-number multiplication, hence the wording of the title. They support evolving thinking in large measure through the ways their users redesign them. They assume new…

  11. Genome-Scale Models

    DEFF Research Database (Denmark)

    Bergdahl, Basti; Sonnenschein, Nikolaus; Machado, Daniel

    2016-01-01

    An introduction to genome-scale models, how to build and use them, will be given in this chapter. Genome-scale models have become an important part of systems biology and metabolic engineering, and are increasingly used in research, both in academica and in industry, both for modeling chemical pr...

  12. Rock Properties Model

    Energy Technology Data Exchange (ETDEWEB)

    C. Lum

    2004-09-16

    The purpose of this model report is to document the Rock Properties Model version 3.1 with regard to input data, model methods, assumptions, uncertainties and limitations of model results, and qualification status of the model. The report also documents the differences between the current and previous versions and validation of the model. The rock properties model provides mean matrix and lithophysae porosity, and the cross-correlated mean bulk density as direct input to the ''Saturated Zone Flow and Transport Model Abstraction'', MDL-NBS-HS-000021, REV 02 (BSC 2004 [DIRS 170042]). The constraints, caveats, and limitations associated with this model are discussed in Section 6.6 and 8.2. Model validation accomplished by corroboration with data not cited as direct input is discussed in Section 7. The revision of this model report was performed as part of activities being conducted under the ''Technical Work Plan for: The Integrated Site Model, Revision 05'' (BSC 2004 [DIRS 169635]). The purpose of this revision is to bring the report up to current procedural requirements and address the Regulatory Integration Team evaluation comments. The work plan describes the scope, objectives, tasks, methodology, and procedures for this process.

  13. Deep Stochastic Radar Models

    OpenAIRE

    Wheeler, Tim Allan; Holder, Martin; Winner, Hermann; Kochenderfer, Mykel

    2017-01-01

    Accurate simulation and validation of advanced driver assistance systems requires accurate sensor models. Modeling automotive radar is complicated by effects such as multipath reflections, interference, reflective surfaces, discrete cells, and attenuation. Detailed radar simulations based on physical principles exist but are computationally intractable for realistic automotive scenes. This paper describes a methodology for the construction of stochastic automotive radar models based on deep l...

  14. Bioeconomic and market models

    Science.gov (United States)

    Richard Haynes; Darius Adams; Peter Ince; John Mills; Ralph Alig

    2006-01-01

    The United States has a century of experience with the development of models that describe markets for forest products and trends in resource conditions. In the last four decades, increasing rigor in policy debates has stimulated the development of models to support policy analysis. Increasingly, research has evolved (often relying on computer-based models) to increase...

  15. Model Breaking Points Conceptualized

    Science.gov (United States)

    Vig, Rozy; Murray, Eileen; Star, Jon R.

    2014-01-01

    Current curriculum initiatives (e.g., National Governors Association Center for Best Practices and Council of Chief State School Officers 2010) advocate that models be used in the mathematics classroom. However, despite their apparent promise, there comes a point when models break, a point in the mathematical problem space where the model cannot,…

  16. A Model Performance

    Science.gov (United States)

    Thornton, Bradley D.; Smalley, Robert A.

    2008-01-01

    Building information modeling (BIM) uses three-dimensional modeling concepts, information technology and interoperable software to design, construct and operate a facility. However, BIM can be more than a tool for virtual modeling--it can provide schools with a 3-D walkthrough of a project while it still is on the electronic drawing board. BIM can…

  17. Model Rockets and Microchips.

    Science.gov (United States)

    Fitzsimmons, Charles P.

    1986-01-01

    Points out the instructional applications and program possibilities of a unit on model rocketry. Describes the ways that microcomputers can assist in model rocket design and in problem calculations. Provides a descriptive listing of model rocket software for the Apple II microcomputer. (ML)

  18. Dynamic term structure models

    DEFF Research Database (Denmark)

    Andreasen, Martin Møller; Meldrum, Andrew

    This paper studies whether dynamic term structure models for US nominal bond yields should enforce the zero lower bound by a quadratic policy rate or a shadow rate specification. We address the question by estimating quadratic term structure models (QTSMs) and shadow rate models with at most four...

  19. Modelling: Nature and Use

    DEFF Research Database (Denmark)

    2011-01-01

    Engineering of products and processes is increasingly “model-centric”. Models in their multitudinous forms are ubiquitous, being heavily used for a range of decision making activities across all life cycle phases. This chapter gives an overview of what is a model, the principal activities in the ...

  20. Simplicial chiral models

    CERN Document Server

    Rossi, P; Rossi, Paolo; Tan, Chung I

    1995-01-01

    Principal chiral models on a d-1 dimensional simplex are introduced and studied analytically in the large N limit. The d = 0 , 2, 4 and \\infty models are explicitly solved. Relationship with standard lattice models and with few-matrix systems in the double scaling limit are discussed.

  1. Modeling agriculture in the Community Land Model

    Directory of Open Access Journals (Sweden)

    B. Drewniak

    2013-04-01

    Full Text Available The potential impact of climate change on agriculture is uncertain. In addition, agriculture could influence above- and below-ground carbon storage. Development of models that represent agriculture is necessary to address these impacts. We have developed an approach to integrate agriculture representations for three crop types – maize, soybean, and spring wheat – into the coupled carbon–nitrogen version of the Community Land Model (CLM, to help address these questions. Here we present the new model, CLM-Crop, validated against observations from two AmeriFlux sites in the United States, planted with maize and soybean. Seasonal carbon fluxes compared well with field measurements for soybean, but not as well for maize. CLM-Crop yields were comparable with observations in countries such as the United States, Argentina, and China, although the generality of the crop model and its lack of technology and irrigation made direct comparison difficult. CLM-Crop was compared against the standard CLM3.5, which simulates crops as grass. The comparison showed improvement in gross primary productivity in regions where crops are the dominant vegetation cover. Crop yields and productivity were negatively correlated with temperature and positively correlated with precipitation, in agreement with other modeling studies. In case studies with the new crop model looking at impacts of residue management and planting date on crop yield, we found that increased residue returned to the litter pool increased crop yield, while reduced residue returns resulted in yield decreases. Using climate controls to signal planting date caused different responses in different crops. Maize and soybean had opposite reactions: when low temperature threshold resulted in early planting, maize responded with a loss of yield, but soybean yields increased. Our improvements in CLM demonstrate a new capability in the model – simulating agriculture in a realistic way, complete with

  2. Mechanics of materials model

    Science.gov (United States)

    Meister, Jeffrey P.

    1987-01-01

    The Mechanics of Materials Model (MOMM) is a three-dimensional inelastic structural analysis code for use as an early design stage tool for hot section components. MOMM is a stiffness method finite element code that uses a network of beams to characterize component behavior. The MOMM contains three material models to account for inelastic material behavior. These include the simplified material model, which assumes a bilinear stress-strain response; the state-of-the-art model, which utilizes the classical elastic-plastic-creep strain decomposition; and Walker's viscoplastic model, which accounts for the interaction between creep and plasticity that occurs under cyclic loading conditions.

  3. Integrated ELM modelling

    Energy Technology Data Exchange (ETDEWEB)

    Loennroth, J.S.; Kiviniemi, T. [Association EURATOM-Tekes, Helsinki University of Technology, P. O. Box 4100, 02015 TKK (Finland); Bateman, G.; Kritz, A. [Lehigh University, Bethlehem, PA (United States); Becoulet, M.; Figarella, C.; Garbet, X.; Huysmans, G. [Association Euratom-CEA, CEA Cadarache (France); Beyer, P. [University of Marseille (France); Corrigan, G.; Fundamenski, W. [UKAEA Fusion Association, Culham Science Centre (United Kingdom); Garcia, O.E.; Naulin, V. [Association Euratom-Risoe National Laboratory, Roskilde (Denmark); Janeschitz, G. [Forschungszentrum Karlsruhe (Germany); Johnson, T. [Association Euratom-VR, Royal Institute of Technology, Stockholm (Sweden); Kuhn, S. [Association Euratom-OeAW, University of Innsbruck (Austria); Loarte, A. [EFDA Close Support Unit, Garching (Germany); Nave, F. [Association Euratom-IST, Centro de Fusao Nuclear, Lisbon (Portugal); Onjun, T. [Sirindhorn International Institute of Technology (Thailand); Pacher, G.W. [Hydro Quebec (Canada); Pacher, H.D.; Pankin, A.; Parail, V.; Pitts, R.; Saibene, G.; Snyder, P.; Spence, J.; Tskhakaya, D.; Wilson, H.

    2006-09-15

    This paper presents a short overview of current trends and progress in integrated ELM modelling. First, the concept of integrated ELM modelling is introduced, various interpretations of it are given and the need for it is discussed. Then follows an overview of different techniques and methods used in integrated ELM modelling presented roughly according to physics approached in use and in order of increasing complexity. The paper concludes with a short discussion of open issues and future modelling requirements within the field of integrated ELM modelling. (copyright 2006 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  4. CRAC2 model description

    Energy Technology Data Exchange (ETDEWEB)

    Ritchie, L.T.; Alpert, D.J.; Burke, R.P.; Johnson, J.D.; Ostmeyer, R.M.; Aldrich, D.C.; Blond, R.M.

    1984-03-01

    The CRAC2 computer code is a revised version of CRAC (Calculation of Reactor Accident Consequences) which was developed for the Reactor Safety Study. This document provides an overview of the CRAC2 code and a description of each of the models used. Significant improvements incorporated into CRAC2 include an improved weather sequence sampling technique, a new evacuation model, and new output capabilities. In addition, refinements have been made to the atmospheric transport and deposition model. Details of the modeling differences between CRAC2 and CRAC are emphasized in the model descriptions.

  5. Validated dynamic flow model

    DEFF Research Database (Denmark)

    Knudsen, Torben

    2011-01-01

    The purpose with this deliverable 2.5 is to use fresh experimental data for validation and selection of a flow model to be used for control design in WP3-4. Initially the idea was to investigate the models developed in WP2. However, in the project it was agreed to include and focus on a additive...... model turns out not to be useful for prediction of the flow. Moreover, standard Box Jenkins model structures and multiple output auto regressive models proves to be superior as they can give useful predictions of the flow....

  6. UZ Colloid Transport Model

    Energy Technology Data Exchange (ETDEWEB)

    M. McGraw

    2000-04-13

    The UZ Colloid Transport model development plan states that the objective of this Analysis/Model Report (AMR) is to document the development of a model for simulating unsaturated colloid transport. This objective includes the following: (1) use of a process level model to evaluate the potential mechanisms for colloid transport at Yucca Mountain; (2) Provide ranges of parameters for significant colloid transport processes to Performance Assessment (PA) for the unsaturated zone (UZ); (3) Provide a basis for development of an abstracted model for use in PA calculations.

  7. Auxiliary Deep Generative Models

    DEFF Research Database (Denmark)

    Maaløe, Lars; Sønderby, Casper Kaae; Sønderby, Søren Kaae;

    2016-01-01

    Deep generative models parameterized by neural networks have recently achieved state-of-the-art performance in unsupervised and semi-supervised learning. We extend deep generative models with auxiliary variables which improves the variational approximation. The auxiliary variables leave...... the generative model unchanged but make the variational distribution more expressive. Inspired by the structure of the auxiliary variable we also propose a model with two stochastic layers and skip connections. Our findings suggest that more expressive and properly specified deep generative models converge...

  8. Transgenesis for pig models

    Science.gov (United States)

    Yum, Soo-Young; Yoon, Ki-Young; Lee, Choong-Il; Lee, Byeong-Chun

    2016-01-01

    Animal models, particularly pigs, have come to play an important role in translational biomedical research. There have been many pig models with genetically modifications via somatic cell nuclear transfer (SCNT). However, because most transgenic pigs have been produced by random integration to date, the necessity for more exact gene-mutated models using recombinase based conditional gene expression like mice has been raised. Currently, advanced genome-editing technologies enable us to generate specific gene-deleted and -inserted pig models. In the future, the development of pig models with gene editing technologies could be a valuable resource for biomedical research. PMID:27030199

  9. Process modeling style

    CERN Document Server

    Long, John

    2014-01-01

    Process Modeling Style focuses on other aspects of process modeling beyond notation that are very important to practitioners. Many people who model processes focus on the specific notation used to create their drawings. While that is important, there are many other aspects to modeling, such as naming, creating identifiers, descriptions, interfaces, patterns, and creating useful process documentation. Experience author John Long focuses on those non-notational aspects of modeling, which practitioners will find invaluable. Gives solid advice for creating roles, work produ

  10. Modeling Epidemic Network Failures

    DEFF Research Database (Denmark)

    Ruepp, Sarah Renée; Fagertun, Anna Manolova

    2013-01-01

    the SID model’s behavior and impact on the network performance, as well as the severity of the infection spreading. The simulations are carried out in OPNET Modeler. The model provides an important input to epidemic connection recovery mechanisms, and can due to its flexibility and versatility be used......This paper presents the implementation of a failure propagation model for transport networks when multiple failures occur resulting in an epidemic. We model the Susceptible Infected Disabled (SID) epidemic model and validate it by comparing it to analytical solutions. Furthermore, we evaluate...

  11. Modeling Epidemic Network Failures

    DEFF Research Database (Denmark)

    Ruepp, Sarah Renée; Fagertun, Anna Manolova

    2013-01-01

    This paper presents the implementation of a failure propagation model for transport networks when multiple failures occur resulting in an epidemic. We model the Susceptible Infected Disabled (SID) epidemic model and validate it by comparing it to analytical solutions. Furthermore, we evaluate...... the SID model’s behavior and impact on the network performance, as well as the severity of the infection spreading. The simulations are carried out in OPNET Modeler. The model provides an important input to epidemic connection recovery mechanisms, and can due to its flexibility and versatility be used...... to evaluate multiple epidemic scenarios in various network types....

  12. Models of Goldstone gauginos

    Science.gov (United States)

    Alves, Daniele S. M.; Galloway, Jamison; McCullough, Matthew; Weiner, Neal

    2016-04-01

    Models with Dirac gauginos are appealing scenarios for physics beyond the Standard Model. They have smaller radiative corrections to scalar soft masses, a suppression of certain supersymmetry (SUSY) production processes at the LHC, and ameliorated flavor constraints. Unfortunately, they are generically plagued by tachyons charged under the Standard Model, and attempts to eliminate such states typically spoil the positive features. The recently proposed "Goldstone gaugino" mechanism provides a simple realization of Dirac gauginos that is automatically free of dangerous tachyonic states. We provide details on this mechanism and explore models for its origin. In particular, we find SUSY QCD models that realize this idea simply and discuss scenarios for unification.

  13. Complex matrix model duality

    Energy Technology Data Exchange (ETDEWEB)

    Brown, T.W.

    2010-11-15

    The same complex matrix model calculates both tachyon scattering for the c=1 non-critical string at the self-dual radius and certain correlation functions of half-BPS operators in N=4 super- Yang-Mills. It is dual to another complex matrix model where the couplings of the first model are encoded in the Kontsevich-like variables of the second. The duality between the theories is mirrored by the duality of their Feynman diagrams. Analogously to the Hermitian Kontsevich- Penner model, the correlation functions of the second model can be written as sums over discrete points in subspaces of the moduli space of punctured Riemann surfaces. (orig.)

  14. Reconstruction of inflation models

    Energy Technology Data Exchange (ETDEWEB)

    Myrzakulov, Ratbay; Sebastiani, Lorenzo [Eurasian National University, Department of General and Theoretical Physics and Eurasian Center for Theoretical Physics, Astana (Kazakhstan); Zerbini, Sergio [Universita di Trento, Dipartimento di Fisica, Trento (Italy); TIFPA, Istituto Nazionale di Fisica Nucleare, Trento (Italy)

    2015-05-15

    In this paper, we reconstruct viable inflationary models by starting from spectral index and tensor-to-scalar ratio from Planck observations. We analyze three different kinds of models: scalar field theories, fluid cosmology, and f(R)-modified gravity. We recover the well-known R{sup 2} inflation in Jordan-frame and Einstein-frame representation, the massive scalar inflaton models and two models of inhomogeneous fluid. A model of R{sup 2} correction to Einstein's gravity plus a ''cosmological constant'' with an exact solution for early-time acceleration is reconstructed. (orig.)

  15. Mathematical modelling techniques

    CERN Document Server

    Aris, Rutherford

    1995-01-01

    ""Engaging, elegantly written."" - Applied Mathematical ModellingMathematical modelling is a highly useful methodology designed to enable mathematicians, physicists and other scientists to formulate equations from a given nonmathematical situation. In this elegantly written volume, a distinguished theoretical chemist and engineer sets down helpful rules not only for setting up models but also for solving the mathematical problems they pose and for evaluating models.The author begins with a discussion of the term ""model,"" followed by clearly presented examples of the different types of mode

  16. Controlling Modelling Artifacts

    DEFF Research Database (Denmark)

    Smith, Michael James Andrew; Nielson, Flemming; Nielson, Hanne Riis

    2011-01-01

    as the high-level model, so that they can be directly compared. There are two key ideas in our approach — a temporal abstraction, where we only look at the state of the system at certain observable points in time, and a spatial abstraction, where we project onto a smaller state space that summarises...... artifacts that were inadvertently introduced. In this paper, we propose a novel methodology to reason about modelling artifacts, given a detailed model and a highlevel (more abstract) model of the same system. By a series of automated abstraction steps, we lift the detailed model to the same state space...

  17. TEAMS Model Analyzer

    Science.gov (United States)

    Tijidjian, Raffi P.

    2010-01-01

    The TEAMS model analyzer is a supporting tool developed to work with models created with TEAMS (Testability, Engineering, and Maintenance System), which was developed by QSI. In an effort to reduce the time spent in the manual process that each TEAMS modeler must perform in the preparation of reporting for model reviews, a new tool has been developed as an aid to models developed in TEAMS. The software allows for the viewing, reporting, and checking of TEAMS models that are checked into the TEAMS model database. The software allows the user to selectively model in a hierarchical tree outline view that displays the components, failure modes, and ports. The reporting features allow the user to quickly gather statistics about the model, and generate an input/output report pertaining to all of the components. Rules can be automatically validated against the model, with a report generated containing resulting inconsistencies. In addition to reducing manual effort, this software also provides an automated process framework for the Verification and Validation (V&V) effort that will follow development of these models. The aid of such an automated tool would have a significant impact on the V&V process.

  18. Models of the universe

    Science.gov (United States)

    Fischer, Arthur E.

    1996-01-01

    In this paper a theory of models of the universe is proposed. We refer to such models ascosmological models, where a cosmological model is defined as an Einstein-inextendible Einstein spacetime. A cosmological model isabsolute if it is a Lorentz-inextendible Einstein spacetime,predictive if it is globally hyperbolic, andnon-predictive if it is nonglobally-hyperbolic. We discuss several features of these models in the study of cosmology. As an example, any compact Einstein spacetime is always a non-predictive absolute cosmological model, whereas a noncompact complete Einstein spacetime is an absolute cosmological model which may be either predictive or non-predictive. We discuss the important role played by maximal Einstein spacetimes. In particular, we examine the possible proper Lorentz-extensions of such spacetimes, and show that a spatially compact maximal Einstein spacetime is exclusively either a predictive cosmological model or a proper sub-spacetime of a non-predictive cosmological model. Provided that the Strong Cosmic Censorship conjecture is true, a generic spatially compact maximal Einstein spacetime must be a predictive cosmological model. It isconjectured that the Strong Cosmic Censorship conjecture isnot true, and converting a vice to a virtue it is argued that the failure of the Strong Cosmic Censorship conjecture would point to what may be general relativity's greatest prediction of all, namely,that general relativity predicts that general relativity cannot predict the entire history of the universe.

  19. Modelling structured data with Probabilistic Graphical Models

    Science.gov (United States)

    Forbes, F.

    2016-05-01

    Most clustering and classification methods are based on the assumption that the objects to be clustered are independent. However, in more and more modern applications, data are structured in a way that makes this assumption not realistic and potentially misleading. A typical example that can be viewed as a clustering task is image segmentation where the objects are the pixels on a regular grid and depend on neighbouring pixels on this grid. Also, when data are geographically located, it is of interest to cluster data with an underlying dependence structure accounting for some spatial localisation. These spatial interactions can be naturally encoded via a graph not necessarily regular as a grid. Data sets can then be modelled via Markov random fields and mixture models (e.g. the so-called MRF and Hidden MRF). More generally, probabilistic graphical models are tools that can be used to represent and manipulate data in a structured way while modeling uncertainty. This chapter introduces the basic concepts. The two main classes of probabilistic graphical models are considered: Bayesian networks and Markov networks. The key concept of conditional independence and its link to Markov properties is presented. The main problems that can be solved with such tools are described. Some illustrations are given associated with some practical work.

  20. Modeling of ultrasound transducers

    DEFF Research Database (Denmark)

    Bæk, David

    deviation of 5.5 % to 11.0 %. Finite element modeling of piezoceramics in combination with Field II is addressed and reveals the influence of restricting the modeling of transducers to the one-dimensional case. An investigation on modeling capacitive micromachined ultrasonic transducers (CMUT)s with Field......This Ph.D. dissertation addresses ultrasound transducer modeling for medical ultrasound imaging and combines the modeling with the ultrasound simulation program Field II. The project firstly presents two new models for spatial impulse responses (SIR)s to a rectangular elevation focused transducer...... II is addressed. It is shown how a single circular CMUT cell can be well approximated with a simple square transducer encapsulating the cell, and how this influence the modeling of full array elements. An optimal cell discretization with Field II’s mathematical elements is addressed as well...

  1. Making business models

    DEFF Research Database (Denmark)

    Gudiksen, Sune Klok; Poulsen, Søren Bolvig; Buur, Jacob

    2014-01-01

    Well-established companies are currently struggling to secure profits due to the pressure from new players' business models as they take advantage of communication technology and new business-model configurations. Because of this, the business model research field flourishes currently; however......, the modelling approaches proposed still rely on linear, rational conceptions and causal reasoning. Through six business cases we argue that participatory design has a role to play, and indeed, can lead the way into another approach to business modelling, which we call business model making. The paper...... illustrates how the application of participatory business model design toolsets can open up discussions on alternative scenarios through improvisation, mock-up making and design game playing, before qualitative judgment on the most promising scenario is carried out....

  2. Foam process models.

    Energy Technology Data Exchange (ETDEWEB)

    Moffat, Harry K.; Noble, David R.; Baer, Thomas A. (Procter & Gamble Co., West Chester, OH); Adolf, Douglas Brian; Rao, Rekha Ranjana; Mondy, Lisa Ann

    2008-09-01

    In this report, we summarize our work on developing a production level foam processing computational model suitable for predicting the self-expansion of foam in complex geometries. The model is based on a finite element representation of the equations of motion, with the movement of the free surface represented using the level set method, and has been implemented in SIERRA/ARIA. An empirically based time- and temperature-dependent density model is used to encapsulate the complex physics of foam nucleation and growth in a numerically tractable model. The change in density with time is at the heart of the foam self-expansion as it creates the motion of the foam. This continuum-level model uses an homogenized description of foam, which does not include the gas explicitly. Results from the model are compared to temperature-instrumented flow visualization experiments giving the location of the foam front as a function of time for our EFAR model system.

  3. Programming Models in HPC

    Energy Technology Data Exchange (ETDEWEB)

    Shipman, Galen M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-06-13

    These are the slides for a presentation on programming models in HPC, at the Los Alamos National Laboratory's Parallel Computing Summer School. The following topics are covered: Flynn's Taxonomy of computer architectures; single instruction single data; single instruction multiple data; multiple instruction multiple data; address space organization; definition of Trinity (Intel Xeon-Phi is a MIMD architecture); single program multiple data; multiple program multiple data; ExMatEx workflow overview; definition of a programming model, programming languages, runtime systems; programming model and environments; MPI (Message Passing Interface); OpenMP; Kokkos (Performance Portable Thread-Parallel Programming Model); Kokkos abstractions, patterns, policies, and spaces; RAJA, a systematic approach to node-level portability and tuning; overview of the Legion Programming Model; mapping tasks and data to hardware resources; interoperability: supporting task-level models; Legion S3D execution and performance details; workflow, integration of external resources into the programming model.

  4. MODERN MEDIA EDUCATION MODELS

    Directory of Open Access Journals (Sweden)

    Alexander Fedorov

    2011-03-01

    Full Text Available The author supposed that media education models can be divided into the following groups:- educational-information models (the study of the theory, history, language of media culture, etc., based on the cultural, aesthetic, semiotic, socio-cultural theories of media education;- educational-ethical models (the study of moral, religions, philosophical problems relying on the ethic, religious, ideological, ecological, protectionist theories of media education;- pragmatic models (practical media technology training, based on the uses and gratifications and ‘practical’ theories of media education;- aesthetical models (aimed above all at the development of the artistic taste and enriching the skills of analysis of the best media culture examples. Relies on the aesthetical (art and cultural studies theory; - socio-cultural models (socio-cultural development of a creative personality as to the perception, imagination, visual memory, interpretation analysis, autonomic critical thinking, relying on the cultural studies, semiotic, ethic models of media education.

  5. Hydrological land surface modelling

    DEFF Research Database (Denmark)

    Ridler, Marc-Etienne Francois

    Recent advances in integrated hydrological and soil-vegetation-atmosphere transfer (SVAT) modelling have led to improved water resource management practices, greater crop production, and better flood forecasting systems. However, uncertainty is inherent in all numerical models ultimately leading...... and disaster management. The objective of this study is to develop and investigate methods to reduce hydrological model uncertainty by using supplementary data sources. The data is used either for model calibration or for model updating using data assimilation. Satellite estimates of soil moisture and surface...... hydrological and tested by assimilating synthetic hydraulic head observations in a catchment in Denmark. Assimilation led to a substantial reduction of model prediction error, and better model forecasts. Also, a new assimilation scheme is developed to downscale and bias-correct coarse satellite derived soil...

  6. Aware design models

    DEFF Research Database (Denmark)

    Tamke, Martin

    2015-01-01

    Appearing almost alive, a novel set of computational design models can become an active counterpart for architects in the design process. The ability to loop, sense and query and the integration of near real-time simulation provide these models with a depth and agility that allows for instant...... and informed feedback. Introducing the term "Aware models", the paper investigates how computational models become an enabler for a better informed architectural design practice, through the embedding of knowledge about constraints, behaviour and processes of formation and making into generative design models....... The inspection of several computational design projects in architectural research highlights three different types of awareness a model can possess and devises strategies to establish and finally design with aware models. This design practice is collaborative in nature and characterized by a bidirectional flow...

  7. Minimal Markov Models

    CERN Document Server

    Gonzalez-Lopez, Jesus E Garcia Veronica A

    2010-01-01

    In this work we introduce a new and richer class of finite order Markov chain models and address the following model selection problem: find the Markov model with the minimal set of parameters (minimal Markov model) which is necessary to represent a source as a Markov chain of finite order. Let us call $M$ the order of the chain and $A$ the finite alphabet, to determine the minimal Markov model, we define an equivalence relation on the state space $A^{M}$, such that all the sequences of size $M$ with the same transition probabilities are put in the same category. In this way we have one set of $(|A|-1)$ transition probabilities for each category, obtaining a model with a minimal number of parameters. We show that the model can be selected consistently using the Bayesian information criterion.

  8. Multiscale Modeling of Recrystallization

    Energy Technology Data Exchange (ETDEWEB)

    Godfrey, A.W.; Holm, E.A.; Hughes, D.A.; Lesar, R.; Miodownik, M.A.

    1998-12-07

    We propose a multi length scale approach to modeling recrystallization which links a dislocation model, a cell growth model and a macroscopic model. Although this methodology and linking framework will be applied to recrystallization, it is also applicable to other types of phase transformations in bulk and layered materials. Critical processes such as the dislocation structure evolution, nucleation, the evolution of crystal orientations into a preferred texture, and grain size evolution all operate at different length scales. In this paper we focus on incorporating experimental measurements of dislocation substructures, rnisorientation measurements of dislocation boundaries, and dislocation simulations into a mesoscopic model of cell growth. In particular, we show how feeding information from the dislocation model into the cell growth model can create realistic initial microstructure.

  9. CREDIT RISK. DETERMINATION MODELS

    Directory of Open Access Journals (Sweden)

    MIHAELA GRUIESCU

    2012-01-01

    Full Text Available The internationalization of financial flows and banking and the rapid development of markets have changed the financial sector, causing him to respond with force and imagination. Under these conditions, the concerns of financial and banking institutions, rating institutions are increasingly turning to find the best solutions to hedge risks and maximize profits. This paper aims to present a number of advantages, but also limits the Merton model, the first structural model for modeling credit risk. Also, some are extensions of the model, some empirical research and performance known, others such as state-dependent models (SDM, which together with the liquidation process models (LPM, are two recent efforts in the structural models, show different phenomena in real life.

  10. Phyloclimatic modeling: combining phylogenetics and bioclimatic modeling.

    Science.gov (United States)

    Yesson, C; Culham, A

    2006-10-01

    We investigate the impact of past climates on plant diversification by tracking the "footprint" of climate change on a phylogenetic tree. Diversity within the cosmopolitan carnivorous plant genus Drosera (Droseraceae) is focused within Mediterranean climate regions. We explore whether this diversity is temporally linked to Mediterranean-type climatic shifts of the mid-Miocene and whether climate preferences are conservative over phylogenetic timescales. Phyloclimatic modeling combines environmental niche (bioclimatic) modeling with phylogenetics in order to study evolutionary patterns in relation to climate change. We present the largest and most complete such example to date using Drosera. The bioclimatic models of extant species demonstrate clear phylogenetic patterns; this is particularly evident for the tuberous sundews from southwestern Australia (subgenus Ergaleium). We employ a method for establishing confidence intervals of node ages on a phylogeny using replicates from a Bayesian phylogenetic analysis. This chronogram shows that many clades, including subgenus Ergaleium and section Bryastrum, diversified during the establishment of the Mediterranean-type climate. Ancestral reconstructions of bioclimatic models demonstrate a pattern of preference for this climate type within these groups. Ancestral bioclimatic models are projected into palaeo-climate reconstructions for the time periods indicated by the chronogram. We present two such examples that each generate plausible estimates of ancestral lineage distribution, which are similar to their current distributions. This is the first study to attempt bioclimatic projections on evolutionary time scales. The sundews appear to have diversified in response to local climate development. Some groups are specialized for Mediterranean climates, others show wide-ranging generalism. This demonstrates that Phyloclimatic modeling could be repeated for other plant groups and is fundamental to the understanding of

  11. Modeling agriculture in the Community Land Model

    Directory of Open Access Journals (Sweden)

    B. Drewniak

    2012-12-01

    Full Text Available The potential impact of climate change on agriculture is uncertain. In addition, agriculture could influence above- and below-ground carbon storage. Development of models that represent agriculture is necessary to address these impacts. We have developed an approach to integrate agriculture representations for three crop types – maize, soybean, and spring wheat – into the coupled carbon-nitrogen version of the Community Land Model (CLM, to help address these questions. Here we present the new model, CLM-Crop, validated against observations from two AmeriFlux sites in the United States, planted with maize and soybean. Seasonal carbon fluxes compared well with field measurements. CLM-Crop yields were comparable with observations in some regions, although the generality of the crop model and its lack of technology and irrigation made direct comparison difficult. CLM-Crop was compared against the standard CLM3.5, which simulates crops as grass. The comparison showed improvement in gross primary productivity in regions where crops are the dominant vegetation cover. Crop yields and productivity were negatively correlated with temperature and positively correlated with precipitation. In case studies with the new crop model looking at impacts of residue management and planting date on crop yield, we found that increased residue returned to the litter pool increased crop yield, while reduced residue returns resulted in yield decreases. Using climate controls to signal planting date caused different responses in different crops. Maize and soybean had opposite reactions: when low temperature threshold resulted in early planting, maize responded with a loss of yield, but soybean yields increased. Our improvements in CLM demonstrate a new capability in the model – simulating agriculture in a realistic way, complete with fertilizer and residue management practices. Results are encouraging, with improved representation of human influences on the land

  12. Modeling local dependence in longitudinal IRT models

    DEFF Research Database (Denmark)

    Larsen, Maja Olsbjerg; Christensen, Karl Bang

    2015-01-01

    Measuring change in a latent variable over time is often done using the same instrument at several time points. This can lead to dependence between responses across time points for the same person yielding within person correlations that are stronger than what can be attributed to the latent...... variable. Ignoring this can lead to biased estimates of changes in the latent variable. In this paper we propose a method for modeling local dependence in the longitudinal 2PL model. It is based on the concept of item splitting, and makes it possible to correctly estimate change in the latent variable....

  13. Constitutive models in LAME.

    Energy Technology Data Exchange (ETDEWEB)

    Hammerand, Daniel Carl; Scherzinger, William Mark

    2007-09-01

    The Library of Advanced Materials for Engineering (LAME) provides a common repository for constitutive models that can be used in computational solid mechanics codes. A number of models including both hypoelastic (rate) and hyperelastic (total strain) constitutive forms have been implemented in LAME. The structure and testing of LAME is described in Scherzinger and Hammerand ([3] and [4]). The purpose of the present report is to describe the material models which have already been implemented into LAME. The descriptions are designed to give useful information to both analysts and code developers. Thus far, 33 non-ITAR/non-CRADA protected material models have been incorporated. These include everything from the simple isotropic linear elastic models to a number of elastic-plastic models for metals to models for honeycomb, foams, potting epoxies and rubber. A complete description of each model is outside the scope of the current report. Rather, the aim here is to delineate the properties, state variables, functions, and methods for each model. However, a brief description of some of the constitutive details is provided for a number of the material models. Where appropriate, the SAND reports available for each model have been cited. Many models have state variable aliases for some or all of their state variables. These alias names can be used for outputting desired quantities. The state variable aliases available for results output have been listed in this report. However, not all models use these aliases. For those models, no state variable names are listed. Nevertheless, the number of state variables employed by each model is always given. Currently, there are four possible functions for a material model. This report lists which of these four methods are employed in each material model. As far as analysts are concerned, this information is included only for the awareness purposes. The analyst can take confidence in the fact that model has been properly implemented

  14. Modeling Quantum Well Lasers

    Directory of Open Access Journals (Sweden)

    Dan Alexandru Anghel

    2012-01-01

    Full Text Available In semiconductor laser modeling, a good mathematical model gives near-reality results. Three methods of modeling solutions from the rate equations are presented and analyzed. A method based on the rate equations modeled in Simulink to describe quantum well lasers was presented. For different signal types like step function, saw tooth and sinus used as input, a good response of the used equations is obtained. Circuit model resulting from one of the rate equations models is presented and simulated in SPICE. Results show a good modeling behavior. Numerical simulation in MathCad gives satisfactory results for the study of the transitory and dynamic operation at small level of the injection current. The obtained numerical results show the specific limits of each model, according to theoretical analysis. Based on these results, software can be built that integrates circuit simulation and other modeling methods for quantum well lasers to have a tool that model and analysis these devices from all points of view.

  15. Geochemical modeling: a review

    Energy Technology Data Exchange (ETDEWEB)

    Jenne, E.A.

    1981-06-01

    Two general families of geochemical models presently exist. The ion speciation-solubility group of geochemical models contain submodels to first calculate a distribution of aqueous species and to secondly test the hypothesis that the water is near equilibrium with particular solid phases. These models may or may not calculate the adsorption of dissolved constituents and simulate the dissolution and precipitation (mass transfer) of solid phases. Another family of geochemical models, the reaction path models, simulates the stepwise precipitation of solid phases as a result of reacting specified amounts of water and rock. Reaction path models first perform an aqueous speciation of the dissolved constituents of the water, test solubility hypotheses, then perform the reaction path modeling. Certain improvements in the present versions of these models would enhance their value and usefulness to applications in nuclear-waste isolation, etc. Mass-transfer calculations of limited extent are certainly within the capabilities of state-of-the-art models. However, the reaction path models require an expansion of their thermodynamic data bases and systematic validation before they are generally accepted.

  16. Modelling Farm Animal Welfare.

    Science.gov (United States)

    Collins, Lisa M; Part, Chérie E

    2013-05-16

    The use of models in the life sciences has greatly expanded in scope and advanced in technique in recent decades. However, the range, type and complexity of models used in farm animal welfare is comparatively poor, despite the great scope for use of modeling in this field of research. In this paper, we review the different modeling approaches used in farm animal welfare science to date, discussing the types of questions they have been used to answer, the merits and problems associated with the method, and possible future applications of each technique. We find that the most frequently published types of model used in farm animal welfare are conceptual and assessment models; two types of model that are frequently (though not exclusively) based on expert opinion. Simulation, optimization, scenario, and systems modeling approaches are rarer in animal welfare, despite being commonly used in other related fields. Finally, common issues such as a lack of quantitative data to parameterize models, and model selection and validation are discussed throughout the review, with possible solutions and alternative approaches suggested.

  17. Modelling Farm Animal Welfare

    Directory of Open Access Journals (Sweden)

    Chérie E. Part

    2013-05-01

    Full Text Available The use of models in the life sciences has greatly expanded in scope and advanced in technique in recent decades. However, the range, type and complexity of models used in farm animal welfare is comparatively poor, despite the great scope for use of modeling in this field of research. In this paper, we review the different modeling approaches used in farm animal welfare science to date, discussing the types of questions they have been used to answer, the merits and problems associated with the method, and possible future applications of each technique. We find that the most frequently published types of model used in farm animal welfare are conceptual and assessment models; two types of model that are frequently (though not exclusively based on expert opinion. Simulation, optimization, scenario, and systems modeling approaches are rarer in animal welfare, despite being commonly used in other related fields. Finally, common issues such as a lack of quantitative data to parameterize models, and model selection and validation are discussed throughout the review, with possible solutions and alternative approaches suggested.

  18. A three-decade-long journey at the College of Optical Sciences

    Science.gov (United States)

    Sarid, Dror

    2014-09-01

    In 1980, Peter Franken, the second director of the Optical Sciences Center, recruited an international quartet of faculty members from the US, Canada, England and Israel (DS). Peter shaped the Center as a clockwork operation, nailing down every aspect of its administration, business model and academic vision. I found myself from day one in a highly competitive environment with extreme peer pressure to make good science and generate a lot of funds. This paper describes the academic journey through my three decades at the Optical Sciences Center that became the College of Optical Sciences (Optical Sciences, in short) until my retirement in 2010, by highlighting selected areas of my group's research.

  19. Production of Sigma{\\pm}pi?pK+ in p+p reactions at 3.5 GeV beam energy

    CERN Document Server

    Agakishiev, G; Belver, D; Belyaev, A; Berger-Chen, J C; Blanco, A; Boehmer, M; Boyard, J L; Cabanelas, P; Castro, E; Chernenko, S; Destefanis, T Christ M; Dohrmann, F; Dybczak, A; Epple, E; Fabbietti, L; Fateev, O; Finocchiaro, P; Fonte, P; Friese, J; Fröhlich, I; Galatyuk, T; Garzon, J A; Gernhäuser, R; Gilardi, C; Golubeva, M; Gonza'lez-Di'az, D; Guber, F; Gumberidze, M; Heinz, T; Hennino, T; Holzmann, R; Ierusalimov, A; Iori, I; Ivashkin, A; Jurkovic, M; Kämpfer, B; Kanaki, K; Karavicheva, T; Koenig, I; Koenig, W; Kolb, B W; Kotte, R; Kr'asa, A; Krizek, F; Krücken, R; Kuc, H; Kuehn, W; Kugler, A; Kurepin, A; Lalik, R; Lang, S; Lange, J S; Lapidus, K; Liu, T; Lopes, L; Lorenz, M; Maier, L; Mangiarotti, A; Markert, J; Metag, V; Michalska, B; Michel, J; Morinie're, E; Mousa, J; Müntz, C; Naumann, L; Otwinowski, J; Pachmayer, Y C; Palka, M; Parpottas, Y; Pechenov, V; Pechenova, O; Pietraszko, J; Przygoda, W; Ramstein, B; Reshetin, A; Rustamov, A; Sadovsky, A; Salabura, P; Schmah, A; Schwab, E; Siebenson, J; Sobolev, Yu G; Spataro, S; Spruck, B; Ströbele, H; Stroth, J; Sturm, C; Tarantola, A; Teilab, K; Tlusty, P; Traxler, M; Trebacz, R; Tsertos, H; Wagner, V; Weber, M; Wendisch, C; Wüstenfeld, J; Yurevich, S; Zanevsky, Y

    2012-01-01

    We study the production of Sigma^+-pi^+-pK^+ particle quartets in p+p reactions at 3.5 GeV kinetic beam energy. The data were taken with the HADES experiment at GSI. This report evaluates the contribution of resonances like Lambda(1405$, Sigma(1385)^0, Lambda(1520), Delta(1232), N^* and K^*0 to the Sigma^+- pi^-+ p K+ final state. The resulting simulation model is compared to the experimental data in several angular distributions and it shows itself as suitable to evaluate the acceptance corrections properly.

  20. Production of Σ±π∓pK+ in p+p reactions at 3.5 GeV beam energy

    Science.gov (United States)

    Agakishiev, G.; Balanda, A.; Belver, D.; Belyaev, A.; Berger-Chen, J. C.; Blanco, A.; Böhmer, M.; Boyard, J. L.; Cabanelas, P.; Castro, E.; Chernenko, S.; Christ, T.; Destefanis, M.; Dohrmann, F.; Dybczak, A.; Epple, E.; Fabbietti, L.; Fateev, O.; Finocchiaro, P.; Fonte, P.; Friese, J.; Fröhlich, I.; Galatyuk, T.; Garzón, J. A.; Gernhäuser, R.; Gilardi, C.; Golubeva, M.; González-Díaz, D.; Guber, F.; Gumberidze, M.; Heinz, T.; Hennino, T.; Holzmann, R.; Ierusalimov, A.; Iori, I.; Ivashkin, A.; Jurkovic, M.; Kämpfer, B.; Kanaki, K.; Karavicheva, T.; Koenig, I.; Koenig, W.; Kolb, B. W.; Kotte, R.; Krása, A.; Krizek, F.; Krücken, R.; Kuc, H.; Kühn, W.; Kugler, A.; Kurepin, A.; Lalik, R.; Lang, S.; Lange, J. S.; Lapidus, K.; Liu, T.; Lopes, L.; Lorenz, M.; Maier, L.; Mangiarotti, A.; Markert, J.; Metag, V.; Michalska, B.; Michel, J.; Morinière, E.; Mousa, J.; Müntz, C.; Münzer, R.; Naumann, L.; Otwinowski, J.; Pachmayer, Y. C.; Palka, M.; Parpottas, Y.; Pechenov, V.; Pechenova, O.; Pietraszko, J.; Przygoda, W.; Ramstein, B.; Reshetin, A.; Rustamov, A.; Sadovsky, A.; Salabura, P.; Schmah, A.; Schwab, E.; Siebenson, J.; Sobolev, Yu. G.; Spataro, S.; Spruck, B.; Ströbele, H.; Stroth, J.; Sturm, C.; Tarantola, A.; Teilab, K.; Tlusty, P.; Traxler, M.; Trebacz, R.; Tsertos, H.; Wagner, V.; Weber, M.; Wendisch, C.; Wüstenfeld, J.; Yurevich, S.; Zanevsky, Y.

    2012-05-01

    We study the production of Σ±π∓pK+ particle quartets in p + p reactions at 3.5 GeV kinetic beam energy. The data were taken with the HADES experiment at GSI. This report evaluates the contribution of resonances like Λ(1405), Σ(1385, Λ(1520), Δ(1232), N* and K*0 to the Σ±π∓pK+ final state. The resulting simulation model is compared to the experimental data in several angular distributions and it shows itself as suitable to evaluate the acceptance corrections properly.

  1. Origin of Chaos in the Prometheus-Pandora System

    CERN Document Server

    Goldreich, P; Goldreich, Peter; Rappaport, Nicole

    2003-01-01

    We demonstrate that the chaotic orbits of Prometheus and Pandora are due to interactions associated with the 121:118 mean motion resonance. Differential precession splits this resonance into a quartet of components equally spaced in frequency. Libration widths of the individual components exceed the splitting resulting in resonance overlap which causes the chaos. A single degree of freedom model captures the essential features of the chaotic dynamics. Mean motions of Prometheus and Pandora wander chaotically in zones of width 1.8 deg/yr and 3.1 deg/yr, respectively.

  2. Product Modelling for Model-Based Maintenance

    NARCIS (Netherlands)

    Houten, van F.J.A.M.; Tomiyama, T.; Salomons, O.W.

    1998-01-01

    The paper describes the fundamental concepts of maintenance and the role that information technology can play in the support of maintenance activities. Function-Behaviour-State modelling is used to describe faults and deterioration of mechanisms in terms of user perception and measurable quantities.

  3. Hydrological land surface modelling

    DEFF Research Database (Denmark)

    Ridler, Marc-Etienne Francois

    to imperfect model forecasts. It remains a crucial challenge to account for system uncertainty, so as to provide model outputs accompanied by a quantified confidence interval. Properly characterizing and reducing uncertainty opens-up the opportunity for risk-based decision-making and more effective emergency...... and disaster management. The objective of this study is to develop and investigate methods to reduce hydrological model uncertainty by using supplementary data sources. The data is used either for model calibration or for model updating using data assimilation. Satellite estimates of soil moisture and surface...... temperature are explored in a multi-objective calibration experiment to optimize the parameters in a SVAT model in the Sahel. The two satellite derived variables were effective at constraining most land-surface and soil parameters. A data assimilation framework is developed and implemented with an integrated...

  4. Aeroservoelasticity modeling and control

    CERN Document Server

    Tewari, Ashish

    2015-01-01

    This monograph presents the state of the art in aeroservoelastic (ASE) modeling and analysis and develops a systematic theoretical and computational framework for use by researchers and practicing engineers. It is the first book to focus on the mathematical modeling of structural dynamics, unsteady aerodynamics, and control systems to evolve a generic procedure to be applied for ASE synthesis. Existing robust, nonlinear, and adaptive control methodology is applied and extended to some interesting ASE problems, such as transonic flutter and buffet, post-stall buffet and maneuvers, and flapping flexible wing. The author derives a general aeroservoelastic plant via the finite-element structural dynamic model, unsteady aerodynamic models for various regimes in the frequency domain, and the associated state-space model by rational function approximations. For more advanced models, the full-potential, Euler, and Navier-Stokes methods for treating transonic and separated flows are also briefly addressed. Essential A...

  5. The IIR evaluation model

    DEFF Research Database (Denmark)

    Borlund, Pia

    2003-01-01

    An alternative approach to evaluation of interactive information retrieval (IIR) systems, referred to as the IIR evaluation model, is proposed. The model provides a framework for the collection and analysis of IR interaction data. The aim of the model is two-fold: 1) to facilitate the evaluation...... assessments. The IIR evaluation model is presented as an alternative to the system-driven Cranfield model (Cleverdon, Mills & Keen, 1966; Cleverdon & Keen, 1966) which still is the dominant approach to the evaluation of IR and IIR systems. Key elements of the IIR evaluation model are the use of realistic...... of IIR systems as realistically as possible with reference to actual information searching and retrieval processes, though still in a relatively controlled evaluation environment; and 2) to calculate the IIR system performance taking into account the non-binary nature of the assigned relevance...

  6. Multiscale cancer modeling.

    Science.gov (United States)

    Deisboeck, Thomas S; Wang, Zhihui; Macklin, Paul; Cristini, Vittorio

    2011-08-15

    Simulating cancer behavior across multiple biological scales in space and time, i.e., multiscale cancer modeling, is increasingly being recognized as a powerful tool to refine hypotheses, focus experiments, and enable more accurate predictions. A growing number of examples illustrate the value of this approach in providing quantitative insights in the initiation, progression, and treatment of cancer. In this review, we introduce the most recent and important multiscale cancer modeling works that have successfully established a mechanistic link between different biological scales. Biophysical, biochemical, and biomechanical factors are considered in these models. We also discuss innovative, cutting-edge modeling methods that are moving predictive multiscale cancer modeling toward clinical application. Furthermore, because the development of multiscale cancer models requires a new level of collaboration among scientists from a variety of fields such as biology, medicine, physics, mathematics, engineering, and computer science, an innovative Web-based infrastructure is needed to support this growing community.

  7. Validation of simulation models

    DEFF Research Database (Denmark)

    Rehman, Muniza; Pedersen, Stig Andur

    2012-01-01

    In philosophy of science, the interest for computational models and simulations has increased heavily during the past decades. Different positions regarding the validity of models have emerged but the views have not succeeded in capturing the diversity of validation methods. The wide variety...... of models has been somewhat narrow-minded reducing the notion of validation to establishment of truth. This article puts forward the diversity in applications of simulation models that demands a corresponding diversity in the notion of validation....... of models with regards to their purpose, character, field of application and time dimension inherently calls for a similar diversity in validation approaches. A classification of models in terms of the mentioned elements is presented and used to shed light on possible types of validation leading...

  8. Spatial cluster modelling

    CERN Document Server

    Lawson, Andrew B

    2002-01-01

    Research has generated a number of advances in methods for spatial cluster modelling in recent years, particularly in the area of Bayesian cluster modelling. Along with these advances has come an explosion of interest in the potential applications of this work, especially in epidemiology and genome research. In one integrated volume, this book reviews the state-of-the-art in spatial clustering and spatial cluster modelling, bringing together research and applications previously scattered throughout the literature. It begins with an overview of the field, then presents a series of chapters that illuminate the nature and purpose of cluster modelling within different application areas, including astrophysics, epidemiology, ecology, and imaging. The focus then shifts to methods, with discussions on point and object process modelling, perfect sampling of cluster processes, partitioning in space and space-time, spatial and spatio-temporal process modelling, nonparametric methods for clustering, and spatio-temporal ...

  9. Multi Scale Modelling

    Energy Technology Data Exchange (ETDEWEB)

    Huemmer, Matthias [AREVA NP GmbH, Paul-Gossen Strasse 100, Erlangen (Germany)

    2008-07-01

    The safety of the Reactor Pressure Vessels (RPV) must be assured and demonstrated by safety assessments against brittle fracture according to the codes and standards. In addition to these deterministic methods, researchers developed statistic methods, so called local approach (LA) models, to predict specimen or component failure. These models transfer the microscopic fracture events to the macro scale by means of Weibull stresses and therefore can describe the fracture behavior more accurate. This paper will propose a recently developed LA model. After the calibration of the model parameters the wide applicability of the model will be demonstrated. Therefore a large number of computations, based on 3D finite element simulations, have been conducted, containing different specimen types and materials in unirradiated and irradiated condition. Comparison of the experimental data with the predictions attained by means of the LA model shows that the fracture behavior can be well described. (authors)

  10. Animal models of scoliosis.

    Science.gov (United States)

    Bobyn, Justin D; Little, David G; Gray, Randolph; Schindeler, Aaron

    2015-04-01

    Multiple techniques designed to induce scoliotic deformity have been applied across many animal species. We have undertaken a review of the literature regarding experimental models of scoliosis in animals to discuss their utility in comprehending disease aetiology and treatment. Models of scoliosis in animals can be broadly divided into quadrupedal and bipedal experiments. Quadrupedal models, in the absence of axial gravitation force, depend upon development of a mechanical asymmetry along the spine to initiate a scoliotic deformity. Bipedal models more accurately mimic human posture and consequently are subject to similar forces due to gravity, which have been long appreciated to be a contributing factor to the development of scoliosis. Many effective models of scoliosis in smaller animals have not been successfully translated to primates and humans. Though these models may not clarify the aetiology of human scoliosis, by providing a reliable and reproducible deformity in the spine they are a useful means with which to test interventions designed to correct and prevent deformity.

  11. Brain Network Modelling

    DEFF Research Database (Denmark)

    Andersen, Kasper Winther

    Three main topics are presented in this thesis. The first and largest topic concerns network modelling of functional Magnetic Resonance Imaging (fMRI) and Diffusion Weighted Imaging (DWI). In particular nonparametric Bayesian methods are used to model brain networks derived from resting state f...... for their ability to reproduce node clustering and predict unseen data. Comparing the models on whole brain networks, BCD and IRM showed better reproducibility and predictability than IDM, suggesting that resting state networks exhibit community structure. This also points to the importance of using models, which...... allow for complex interactions between all pairs of clusters. In addition, it is demonstrated how the IRM can be used for segmenting brain structures into functionally coherent clusters. A new nonparametric Bayesian network model is presented. The model builds upon the IRM and can be used to infer...

  12. Outside users payload model

    Science.gov (United States)

    1985-01-01

    The outside users payload model which is a continuation of documents and replaces and supersedes the July 1984 edition is presented. The time period covered by this model is 1985 through 2000. The following sections are included: (1) definition of the scope of the model; (2) discussion of the methodology used; (3) overview of total demand; (4) summary of the estimated market segmentation by launch vehicle; (5) summary of the estimated market segmentation by user type; (6) details of the STS market forecast; (7) summary of transponder trends; (8) model overview by mission category; and (9) detailed mission models. All known non-NASA, non-DOD reimbursable payloads forecast to be flown by non-Soviet-block countries are included in this model with the exception of Spacelab payloads and small self contained payloads. Certain DOD-sponsored or cosponsored payloads are included if they are reimbursable launches.

  13. Developing mathematical modelling competence

    DEFF Research Database (Denmark)

    Blomhøj, Morten; Jensen, Tomas Højgaard

    2003-01-01

    In this paper we introduce the concept of mathematical modelling competence, by which we mean being able to carry through a whole mathematical modelling process in a certain context. Analysing the structure of this process, six sub-competences are identified. Mathematical modelling competence...... cannot be reduced to these six sub-competences, but they are necessary elements in the development of mathematical modelling competence. Experience from the development of a modelling course is used to illustrate how the different nature of the sub-competences can be used as a tool for finding...... the balance between different kinds of activities in a particular educational setting. Obstacles of social, cognitive and affective nature for the students' development of mathematical modelling competence are reported and discussed in relation to the sub-competences....

  14. Identification of physical models

    DEFF Research Database (Denmark)

    Melgaard, Henrik

    1994-01-01

    The problem of identification of physical models is considered within the frame of stochastic differential equations. Methods for estimation of parameters of these continuous time models based on descrete time measurements are discussed. The important algorithms of a computer program for ML or MAP...... design of experiments, which is for instance the design of an input signal that are optimal according to a criterion based on the information provided by the experiment. Also model validation is discussed. An important verification of a physical model is to compare the physical characteristics...... of the model with the available prior knowledge. The methods for identification of physical models have been applied in two different case studies. One case is the identification of thermal dynamics of building components. The work is related to a CEC research project called PASSYS (Passive Solar Components...

  15. New quantum mechanical model

    Institute of Scientific and Technical Information of China (English)

    吴宁; 阮图南

    1996-01-01

    A quantum mechanical model with one bosonic degree of freedom is discussed in detail. Conventionally, when a quantum mechanical model is constructed, one must know the corresponding classical model. And by applying the correspondence between the classical Poisson brackets and the canonical commutator, the canonical quantization condition can be obtained. In the quantum model, study of the corresponding classical model is needed first. In this model, the Lagrangian is an operator gauge invariant. After localization, in order to keep gauge invariance, the operator gauge potential must be introduced. The Eular-Lagrange equation of motion of the dynamical argument gives the usual operator equation of motion. And the operator gauge potential just gjves a constraint. This constraint is just the usual canonical quantization condition.

  16. Essentials of econophysics modelling

    CERN Document Server

    Slanina, Frantisek

    2014-01-01

    This book is a course in methods and models rooted in physics and used in modelling economic and social phenomena. It covers the discipline of econophysics, which creates an interface between physics and economics. Besides the main theme, it touches on the theory of complex networks and simulations of social phenomena in general. After a brief historical introduction, the book starts with a list of basic empirical data and proceeds to thorough investigation of mathematical and computer models. Many of the models are based on hypotheses of the behaviour of simplified agents. These comprise strategic thinking, imitation, herding, and the gem of econophysics, the so-called minority game. At the same time, many other models view the economic processes as interactions of inanimate particles. Here, the methods of physics are especially useful. Examples of systems modelled in such a way include books of stock-market orders, and redistribution of wealth among individuals. Network effects are investigated in the inter...

  17. Compositional Modeling with DPNs

    Science.gov (United States)

    2007-11-02

    Technical Report Compositional Modeling with DPNs 6. AUTHOR(S) Geoffrey Zweig and Stuart Russell 7. PERFORMING ORGANIZATION NAMES(S) AND ADDRESS(ES...Standard Form 298 (Rev. 2-89) Prescribed by ANSI Std. 239-18 298-102 Compositional Modeling With DPNs Geoffrey Zweig Stuart Russell Report No. UCB...Modeling With DPNs Geoffrey Zweig * Stuart Russell * Sept. 8, 1997 Abstract Dynamic probabilistic networks (DPNs) are a powerful and efficient method for

  18. Genomic Feature Models

    DEFF Research Database (Denmark)

    Sørensen, Peter; Edwards, Stefan McKinnon; Rohde, Palle Duun

    Whole-genome sequences and multiple trait phenotypes from large numbers of individuals will soon be available in many populations. Well established statistical modeling approaches enable the genetic analyses of complex trait phenotypes while accounting for a variety of additive and non-additive g...... regions and gene ontologies) that provide better model fit and increase predictive ability of the statistical model for this trait....

  19. Modelling the Photovoltaic Module

    DEFF Research Database (Denmark)

    Katsanevakis, Markos

    2011-01-01

    computational time. After the decision of the proper model, a process which is called parameter extraction is going to take place in order to fully determine the unknowns of the model and therefore be able to simulate it. Last but not least the results and the verification process are going to take place...... in order to validate the proper function of the model using widely used simulation software and the manufacturer’s datasheet....

  20. Solid model design simplification

    Energy Technology Data Exchange (ETDEWEB)

    Ames, A.L.; Rivera, J.J.; Webb, A.J.; Hensinger, D.M.

    1997-12-01

    This paper documents an investigation of approaches to improving the quality of Pro/Engineer-created solid model data for use by downstream applications. The investigation identified a number of sources of problems caused by deficiencies in Pro/Engineer`s geometric engine, and developed prototype software capable of detecting many of these problems and guiding users towards simplified, useable models. The prototype software was tested using Sandia production solid models, and provided significant leverage in attacking the simplification problem.