WorldWideScience

Sample records for quality control study

  1. Studies of quality control procedures for radiopharmaceuticals

    International Nuclear Information System (INIS)

    Zivanovic, M.; Trott, N.G.

    1983-01-01

    In this paper, a short description is given of a radiopharmaceutical preparation suite set up at the Royal Marsden Hospital and an account is presented of methods used for quality control of radiopharmaceuticals and of the results obtained over a period of about two and a half years

  2. Descriptive study of the quality control in mammography

    International Nuclear Information System (INIS)

    Gaona, E.; Perdigon C, G.M.; Casian C, G.A.; Azorin N, J.; Diaz G, J.A.I.; Arreola, M.

    2005-01-01

    The goal of mammography is to provide contrast between a lesion that is possible residing within the breast and normal surrounding tissue. Quality control is essential for maintaining the contrast imaging performance of a mammography system and incorporate tests that are relevant in that they are predictive of future degradation of contrast imaging performance. These tests will also be done at frequency that is high enough to intercept most drifts in quality imaging or performance before they become diagnostically significant. The quality control study has as objective to describe the results of the assessment of quality imaging elements (film optical density, contrast (density difference), uniformity, resolution and noise) of 62 mammography departments without quality control program and comparison these results with a mammography reference department with a quality control program. When comparing the results they allow seeing the clinical utility of to have a quality control program to reduce the errors of mammography interpretation. (Author)

  3. The study on quality control of bedside CR examination

    International Nuclear Information System (INIS)

    Yang Xufeng; Luo Xiaomei; Xu Qiaolan; Wu Tengfang; Wen Xingwei

    2007-01-01

    Objective: To study the quality controll of bedside CR examination and improves the imaging quality. Methods: X-ray examination with CR system were performed on 3,300 patients. All CR cassettes were encoded. The imaging plate and cassettes were cleaned regularly. Results: With and without quality control, the percentage of first-rate film was 58.2% and 51%, the second-rate film was 40% and 45.5%, the third-rate film was 1.3% and 2%, respectively. Corxespondingly, the ratio of re-examination decreased from 1.5% to 0.5% after quality control, and imaging quality was stable. Conclusion: The quality control of bedside CR examination can improve the image quality as well as lighten the labor of radiographers. (authors)

  4. The Study on quality control of nuclear power installation project

    International Nuclear Information System (INIS)

    Wu Jie

    2008-01-01

    The quality planning, quality assurance and quality control are discussed by applying the quality control (QC) theory and combining the real situation of the Qinshan II project. This paper is practical and plays an active role in instruction of project quality control by applying the above QC theory and control techniques. (authors)

  5. Quality control for exposure assessment in epidemiological studies

    DEFF Research Database (Denmark)

    Bornkessel, C; Blettner, M; Breckenkamp, J

    2010-01-01

    In the framework of an epidemiological study, dosemeters were used for the assessment of radio frequency electromagnetic field exposure. To check the correct dosemeter's performance in terms of consistency of recorded field values over the entire study period, a quality control strategy...... was developed. In this paper, the concept of quality control and its results is described. From the 20 dosemeters used, 19 were very stable and reproducible, with deviations of a maximum of +/-1 dB compared with their initial state. One device was found to be faulty and its measurement data had to be excluded...... from the analysis. As a result of continuous quality control procedures, the confidence in the measurements obtained during the field work was strengthened significantly....

  6. Descriptive study of the quality control in mammography; Estudio descriptivo del control de calidad en mamografia

    Energy Technology Data Exchange (ETDEWEB)

    Gaona, E.; Perdigon C, G.M.; Casian C, G.A.; Azorin N, J.; Diaz G, J.A.I.; Arreola, M. [UAM, Xochimilco 14000 Mexico D.F. (Mexico)

    2005-07-01

    The goal of mammography is to provide contrast between a lesion that is possible residing within the breast and normal surrounding tissue. Quality control is essential for maintaining the contrast imaging performance of a mammography system and incorporate tests that are relevant in that they are predictive of future degradation of contrast imaging performance. These tests will also be done at frequency that is high enough to intercept most drifts in quality imaging or performance before they become diagnostically significant. The quality control study has as objective to describe the results of the assessment of quality imaging elements (film optical density, contrast (density difference), uniformity, resolution and noise) of 62 mammography departments without quality control program and comparison these results with a mammography reference department with a quality control program. When comparing the results they allow seeing the clinical utility of to have a quality control program to reduce the errors of mammography interpretation. (Author)

  7. Experimental study and quality control of a technetium-99 generator

    International Nuclear Information System (INIS)

    Jimeno de Osso, F.

    1981-01-01

    The performarce of a generator of technetium-99m to be used in nuclear medicine is studied. The most interesting characteristic of this generator is the use of a U-shaped chromatographuc column so as to improve its efficiency and design without increasing the weight of its shield. With the aim of improving certain aspects of the generator, molibdenum-99 was applied to adecuate pH, pirogens were removed from the column set up before application, application was effected on a dry column, the smallest alumina particles were separated on the column, etc. The most important parameters of an isotopic generator are studied, and the corresponding quality controls performed. (author)

  8. CASE STUDY ON WATER QUALITY CONTROL IN AN AQUAPONIC SYSTEM

    Directory of Open Access Journals (Sweden)

    Radu Mihai Filep

    2016-07-01

    Full Text Available Aquaponic systems are integrated systems that combine fish farming and different types of plants. It involves a dynamic interaction between fish plants and bacteria. Fish and plants are dependent the equilibrium of dissolved nutrients and water quality. Only by striking a balance between dissolved nutrients and water quality we can achieve a large production of plants and healthy fish. Thus, control of water quality in an aquaponic system is essential in order to obtain performance in raising fish and plants. The experiment was conducted in the laboratory of Fisheries and Aquaculture of the Faculty of Animal Science of the University of Agronomic Sciences and Veterinary Medicine of Bucharest within a period of 30 days. The system used for the experiment was designed and developed in the laboratory mentioned above. The plant used for water treatment in the system was basil (Ocimum basilicum. Fish species grown in the system was culture carp (Cyprinus carpio. Indicators measured to assess water quality in the system were: temperature, pH, dissolved oxygen, total ammonia, nitrites, nitrates and phosphates. The values determined pH 7.4-7.6, dissolved oxygen 8-10 mg / l, NH4 0.05-05 mg/ l, NO2 0.1-3.2 mg / l, NO3 0-80 mg / l, 0.02-0.3 mg, PO4 0.02-0.3 mg/l were not too high. In conclusion it was demonstrated that water quality in the aquaponic system studied is propitious to the growth and welfare of fish the registered values are not to be harmful.

  9. quality control

    International Nuclear Information System (INIS)

    Skujina, A.; Purina, S.; Riekstina, D.

    1999-01-01

    The optimal objects: soils, spruce needles and bracken ferns were found for the environmental monitoring in the regions of possible radioactive contamination - near SalaspiIs nuclear reactor and Ignalina nuclear power plant. The determination of Sr-90 was based on the radiochemical separation of Sr-90 (=Y-90) by HDEHP extraction and counting the Cerenkov radiation. The quality control of the results was carried out. (authors)

  10. MRI quality control: six imagers studied using eleven unified image quality parameters

    International Nuclear Information System (INIS)

    Ihalainen, T.; Sipilae, O.; Savolainen, S.

    2004-01-01

    Quality control of the magnetic resonance imagers of different vendors in the clinical environment is non-harmonised, and comparing the performance is difficult. The purpose of this study was to develop and apply a harmonised long-term quality control protocol for the six imagers in our organisation in order to assure that they fulfil the same basic image quality requirements. The same Eurospin phantom set and identical imaging parameters were used with each imager. Values of 11 comparable parameters describing the image quality were measured. Automatic image analysis software was developed to objectively analyse the images. The results proved that the imagers were operating at a performance level adequate for clinical imaging. Some deficiencies were detected in image uniformity and geometry. The automated analysis of the Eurospin phantom images was successful. The measurements were successfully repeated after 2 weeks on one imager and after half a year on all imagers. As an objective way of examining the image quality, this kind of comparable and objective quality control of different imagers is considered as an essential step towards harmonisation of the clinical MRI studies through a large hospital organisation. (orig.)

  11. Homogeneity Study of UO2 Pellet Density for Quality Control

    International Nuclear Information System (INIS)

    Moon, Je Seon; Park, Chang Je; Kang, Kwon Ho; Moon, Heung Soo; Song, Kee Chan

    2005-01-01

    A homogeneity study has been performed with various densities of UO 2 pellets as the work of a quality control. The densities of the UO 2 pellets are distributed randomly due to several factors such as the milling conditions and sintering environments, etc. After sintering, total fourteen bottles were chosen for UO 2 density and each bottle had three samples. With these bottles, the between-bottle and within-bottle homogeneity were investigated via the analysis of the variance (ANOVA). From the results of ANOVA, the calculated F-value is used to determine whether the distribution is accepted or rejected from the view of a homogeneity under a certain confidence level. All the homogeneity checks followed the International Standard Guide 35

  12. Analytical quality control in studies of environmental exposure to mercury

    International Nuclear Information System (INIS)

    Byrne, A.R.; Prosenc, N.; Smerke, J.; Horvat, M.

    1995-01-01

    The work of the laboratory for quality control in this co-ordinated project for the period from November 1993 to June 1994 is presented. The major effort was devoted to assisting in establishing the homogeneity and total methylmercury levels in two new hair reference materials prepared as control materials for the project, numbered 085 (spiked) and 086 (natural level). Results for some hair materials from participants are also given. (author)

  13. Retrospective exposure assessment and quality control in an international multi-centre case-control study

    DEFF Research Database (Denmark)

    Tinnerberg, H; Heikkilä, P; Huici-Montagud, A

    2003-01-01

    The paper presents the exposure assessment method and quality control procedure used in an international, multi-centre case-control study within a joint Nordic and Italian cohort. This study was conducted to evaluate whether occupational exposure to carcinogens influenced the predictivity of high...... was higher among the original assessors (the assessor from the same country as the subject) than the average prevalence assessed by the other four in the quality control round. The original assessors classified more job situations as exposed than the others. Several reasons for this are plausible: real...... country-specific differences, differences in information available to the home assessor and the others and misunderstandings or difficulties in translation of information. To ensure the consistency of exposure assessments in international retrospective case-control studies it is important to have a well...

  14. Quality Control Applications

    CERN Document Server

    Chorafas, Dimitris N

    2013-01-01

    Quality control is a constant priority in electrical, mechanical, aeronautical, and nuclear engineering – as well as in the vast domain of electronics, from home appliances to computers and telecommunications. Quality Control Applications provides guidance and valuable insight into quality control policies; their methods, their implementation, constant observation and associated technical audits. What has previously been a mostly mathematical topic is translated here for engineers concerned with the practical implementation of quality control. Once the fundamentals of quality control are established, Quality Control Applications goes on to develop this knowledge and explain how to apply it in the most effective way. Techniques are described and supported using relevant, real-life, case studies to provide detail and clarity for those without a mathematical background. Among the many practical examples, two case studies dramatize the importance of quality assurance: A shot-by-shot analysis of the errors made ...

  15. Study on quality control of Chinese herb medicine irradiation

    International Nuclear Information System (INIS)

    Yang Dongqing; En Lihua; Deng Wenmin

    2010-01-01

    6-8 kGy γ-ray irradiation dosage treatment can reduce the bacteria, mildew effectively from 105 CFU/g to 102 CFU/g and eliminate the parasite in 4 kind of Chinese herb medicine, enhance their quality of sanitation observably. In the other hand, irradiation doesn't influence the medicinal component and therapy effect. Storage study has improved that the 4 kind of Chinese herb medicine treated by γ-ray irradiation can be preserved over one year in the room temperature with high quality of sanitation and steady medicinal component. (authors)

  16. IAEA Reference Materials for Quality Assurance: A Study in the Quality Control of Marine Radioactivity

    International Nuclear Information System (INIS)

    Pham Mai Khanh; Bartocci, J.; Gastaud, J.; Nies, H.; Vasileva, E.; Betti, M.; Chamizo, E.; Gomez-Guzman, J.-M.

    2013-01-01

    The IAEA's Marine Environment Laboratories has assisted laboratories in Analytical Quality Control Services (AQCS) for the analysis of radionuclides in the marine environment since the early seventies. The AQCS programme, now named Reference Products for Environment and Trade, is recognized as an essential component of quality assurance and control and for the development and validation of analytical methods, through its worldwide and regional interlaboratory comparisons and the provision of reference methods and Reference Materials/Certified Reference Materials (RMs/CRMs). A total of 49 interlaboratory exercises were organized and 42 RMs/CRMs were produced for marine radioactivity studies. Different techniques such as radiometric methods with X ray, gamma spectrometry, alpha spectrometry, beta counter, liquid scintillation counter as well as mass spectrometry (ICP-MS, AMS, TIMS) are applied for the characterization during certification process. An overview of prepared Certified Reference Materials (CRMs) for radionuclides in marine matrices will be presented as well as lessons learned from interlaboratory comparisons (ICs) and Proficiency Tests (PTs). A characterization of a new CRM for radionuclides in IAEA-446, Baltic Sea seaweed (Fucus vesiculosus), as well as a specific case of using Accelerator Mass Spectrometry (AMS) technique to characterize I-129 in sea water (IAEA-418) and seaweed sample (IAEA-446), will be discussed. Available RMs/CRMs are listed and can be ordered and purchased through the IAEA website http://nucleus.iaea.org/rpst/. (author)

  17. IAEA Reference Materials for Quality Assurance: A Study in the Quality Control of Marine Radioactivity

    Energy Technology Data Exchange (ETDEWEB)

    Khanh, Pham Mai; Bartocci, J.; Gastaud, J.; Nies, H.; Vasileva, E.; Betti, M. [International Atomic Energy Agency, Environment Laboratory (Monaco); Chamizo, E.; Gomez-Guzman, J. -M. [Centro Nacional de Aceleradores, Seville (Spain)

    2013-07-15

    The IAEA's Marine Environment Laboratories has assisted laboratories in Analytical Quality Control Services (AQCS) for the analysis of radionuclides in the marine environment since the early seventies. The AQCS programme, now named Reference Products for Environment and Trade, is recognized as an essential component of quality assurance and control and for the development and validation of analytical methods, through its worldwide and regional interlaboratory comparisons and the provision of reference methods and Reference Materials/Certified Reference Materials (RMs/CRMs). A total of 49 interlaboratory exercises were organized and 42 RMs/CRMs were produced for marine radioactivity studies. Different techniques such as radiometric methods with X ray, gamma spectrometry, alpha spectrometry, beta counter, liquid scintillation counter as well as mass spectrometry (ICP-MS, AMS, TIMS) are applied for the characterization during certification process. An overview of prepared Certified Reference Materials (CRMs) for radionuclides in marine matrices will be presented as well as lessons learned from interlaboratory comparisons (ICs) and Proficiency Tests (PTs). A characterization of a new CRM for radionuclides in IAEA-446, Baltic Sea seaweed (Fucus vesiculosus), as well as a specific case of using Accelerator Mass Spectrometry (AMS) technique to characterize I-129 in sea water (IAEA-418) and seaweed sample (IAEA-446), will be discussed. Available RMs/CRMs are listed and can be ordered and purchased through the IAEA website http://nucleus.iaea.org/rpst/. (author)

  18. A comparative study of quality control in diagnostic radiology

    International Nuclear Information System (INIS)

    Kharita, M. H.; Khedr, M.S.; Wannus, K.M.

    2008-01-01

    The main objective of this comparative study was to evaluate the national quality assurance program for X-ray diagnostic radiology in Syrian governmental hospitals. Two periods were covered in this study, the first period was from 1986 to 1998 (52 hospitals and 149 X-ray machines were considered) and the second period from 1999 to 2005 (41 hospitals and 95 X-ray machines were considered). Most of the X-ray machines studied were within the acceptable performance, but few machines needed recalibration for some parameters. Considerable improvement of about 50% was reported in the second period. This improvement could be attributed to the establishment of an effective National Regulatory Authority in Syria in 1998 that introduced and gradually enforced the quality assurance requirement for X-ray equipment as part of the licensing process and to the relatively newer X-ray machines covered in the second period. The Author 2008. Published by Oxford Univ. Press. All rights reserved. (authors)

  19. Studies on quality control of technetium-99m labelling kits

    International Nuclear Information System (INIS)

    Kim, Jae Rok; Park, Kyung Bae; Awh, Ok Doo

    1987-12-01

    Various experiments for the quality control of Tc-99m labelled radiopharmaceuticals such as Tc-99m-phytate, Tc-99m-MDP, Tc-99m-Tin Colloid, Tc-99m-DISIDA, Tc-99m-DTPA,Tc-99m-DMSA, Tc-99m-Gulcoheptonate, TC-99m-Pyrophosphate, Tc-99m-HSA, and Tc-99m-HAM were carried out. Labelling yield and radiochemical purity of each of the instant labelling kit of KAERI made were determined by means of radiochromatography. Biodistribution in mice and whole body or specific organ imagings of rabbits were also carried out and discussed the relationship between the data of biodistributions and radiochemical purities. Labelling yeilds were above 98% for almost all of the labelling kits. The radio-pharmaceuticals were accumulated at each target organ with moderate specifities. In case of radiochemical purity of above 98%, the biodistribution and gamma imagings were also better. The kits of MDP and DISIDA were stable at least for four moths while the other kits at least eight months. (Author)

  20. Quality control of intelligence research

    International Nuclear Information System (INIS)

    Lu Yan; Xin Pingping; Wu Jian

    2014-01-01

    Quality control of intelligence research is the core issue of intelligence management, is a problem in study of information science This paper focuses on the performance of intelligence to explain the significance of intelligence research quality control. In summing up the results of the study on the basis of the analysis, discusses quality control methods in intelligence research, introduces the experience of foreign intelligence research quality control, proposes some recommendations to improve quality control in intelligence research. (authors)

  1. Comparison of studies realized with quality control and without it in nuclear medicine

    International Nuclear Information System (INIS)

    Manzo, Aisa

    2001-01-01

    SPECT studies are revised, either cerebral or cardiac, showing, in the first place, the radiopharmaceuticals used with their radio chemical characteristics; afterwards excellent quality studies are compared with studies presenting defects attributable no to the patient pathology but to a flaw in the quality control of equipment being used [es

  2. QUALITY CONTROL IN PRECAST PRODUCTION A case study on Tunnel Segment Manufacture

    Directory of Open Access Journals (Sweden)

    Yee Weng Cheong

    2005-01-01

    Full Text Available Quality control forms an integral part of precast production. An efficient quality system is most critical in the mass production of precast components in any project. In this study, the quality control system implemented in a precast factory is discussed. The precast factory is set up for the manufacture of large quantity of tunnel segments under a contract. Processes in the precast manufacture are discussed with respect to the control procedures in the quality inspection plan. The standard tests involved, roles of inspectors and corrective actions on-site are highlighted. Critical issues pertaining to the productivity and quality of precast production are reviewed. These include the quality of staff and maintenance, which could potentially affect the efficiency of the quality system. Some considerations should also be given to improve the workflow and productivity of the plant.

  3. Internal Structure Quality Control of Solid Pharmaceuticals. A Comparative Study

    Directory of Open Access Journals (Sweden)

    Imre Silvia

    2016-03-01

    Full Text Available Objective: The aim of the study was a comparative investigation by spectral and thermal analysis in order to asses a number of characteristics of different varieties ofrawmaterials of ursodeoxycholic acid and ibuprofen. The different dissolution behavior of two ursodeoxycholic acid pharmaceutical product by crystallinity pattern was investigated. Methods: Raw materials of ursodeoxycholic acid and ibuprofen were used. IR spectroscopy, differential scanning calorimetry and X-Ray Diffraction Analysis were applied. Results: The results show no crystallinitydifferences for different batches of the tested drugs. No solid solid transition was proved during sample preparation for transmission IR analysis. Conclusions: A combination of two more affordabletests by IR spectrometry and differential scanning calorimetry lead to the same results as X-Ray diffraction analysis for crystallinity similarity assessment of the studied substances. The dissolution differences of test drugs were not related to the polymorphism of the raw materials.

  4. [Study of quality control on Cuscuta chinensis and C. australia].

    Science.gov (United States)

    Lin, Hui-bin; Lin, Jian-qun; Lu, Ning; Lin, Jian-qiang

    2007-11-01

    To study the estimate method of C. chinensis and C. australia. HPLC was used to determine the contents of four kinds of flavones of C. chinensis and C. australia growing on different hosts. C. chinensis and C. australia growing on different hosts both had hyperoside, quercetin, kaempferol and isorhamnetin. The content range of hyperoside was 2.790-6.502 mg/g and was higher than other flavones. The content ranges of quercetin, kaempferol and isorhamnetin were 0.025-0.176 mg/g, 0.001-0.213 mg/g and 0.001-0.077 mg/g, respectively. The contents of hyperoside and quercetin are higher in C. chineasis than in C. australia. The contents of kaempferol and isorhamnetin are lower in C. chinensis than in C. australia. The hosts influence flavones content of C. chinensis and C. australia.

  5. Study on quality control measures of static casting main pipe in PWR nuclear power plant

    International Nuclear Information System (INIS)

    Jiang Zhenbiao; Li Guanying; Liu Zhicheng

    2013-01-01

    This study analyzes the main reasons which impact the quality of primary pipe static casting elbows in PWR-M310 nuclear power plant. The quality control measures are developed from the election and inspection of material, improving sand production and casting process, improving lean management of personnel. The static casting defects of primary pipe elbows for Fuqing Unit 1 and 2 were down to less than 50% of the former project. The quality of static casting for the primary pipe elbows was significantly improved. Moreover, the implementation saves human resources and financing to repair casting defects, and also helps to win the delivery schedule. The quality control measures are good reference for improving primary pipe casting process. This study provides valuable experience for further study of improving the quality of static casting for the primary pipe of PWR nuclear power plant. (authors)

  6. SPECT quality control tests

    International Nuclear Information System (INIS)

    Robilotta, C.C.; Rebelo, M.F.S.; Oliveira, M.A.; Abe, R.

    1987-01-01

    Quality control tests of tomographic system composed by a rotatory chamber (CGR Gammatomome T-9000) and a microcomputer are presented. Traditional quality control tests for scintilation chambers and specific tests for tomographic systems are reported. (M.A.C.) [pt

  7. Multi-criteria decision making approaches for quality control of genome-wide association studies.

    Science.gov (United States)

    Malovini, Alberto; Rognoni, Carla; Puca, Annibale; Bellazzi, Riccardo

    2009-03-01

    Experimental errors in the genotyping phases of a Genome-Wide Association Study (GWAS) can lead to false positive findings and to spurious associations. An appropriate quality control phase could minimize the effects of this kind of errors. Several filtering criteria can be used to perform quality control. Currently, no formal methods have been proposed for taking into account at the same time these criteria and the experimenter's preferences. In this paper we propose two strategies for setting appropriate genotyping rate thresholds for GWAS quality control. These two approaches are based on the Multi-Criteria Decision Making theory. We have applied our method on a real dataset composed by 734 individuals affected by Arterial Hypertension (AH) and 486 nonagenarians without history of AH. The proposed strategies appear to deal with GWAS quality control in a sound way, as they lead to rationalize and make explicit the experimenter's choices thus providing more reproducible results.

  8. Interaction between production control and quality control

    NARCIS (Netherlands)

    Bij, van der J.D.; Ekert, van J.H.W.

    1999-01-01

    Describes a qualitative study on interaction between systems for production control and quality control within industrial organisations. Production control and quality control interact in a sense. Good performance for one aspect often influences or frustrates the performance of the other. As far as

  9. Quality assurance and quality control

    International Nuclear Information System (INIS)

    Kaden, W.

    1986-01-01

    General preconditions and methods for QA work in the nuclear field are analysed. The application of general QA principles to actual situations is illustrated by examples in the fields of engineering and of the manufacturing of mechanical and electrical components. All QA measures must be fitted to the complexity and relevance of the work steps, which are under consideration. The key to good product quality is the control of working processes. The term 'controlled process' is discussed in detail and examples of feed back systems are given. The main QA measures for the operation of nuclear power plants include the establishment of a Quality Assurance Program, training and qualification of personnel, procurement control, inspection and tests, reviews and audits. These activities are discussed. (orig.)

  10. Quality assurance and quality control

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    The practice of nuclear diagnostic imaging requires an appropriate quality assurance program to attain high standards of efficiency and reliability. The International Atomic Energy Agency defines the term quality assurance as ''the closeness with which the outcome of a given procedure approaches some ideal, free from all errors and artifacts.'' The term quality control is used in reference to the specific measures taken to ensure that one particular aspect of the procedure is satisfactory. Therefore, quality assurance is a hospital-wide concept that should involve all aspects of clinical practice. Quality control is concerned with the submission of requests for procedures; the scheduling of patients; the preparation and dispensing of radiopharmaceuticals; the protection of patients, staff, and the general public against radiation hazards and accidents caused by radioactive materials or by faulty equipment; the setting up, use, and maintenance of electronic instruments; the methodology of the actual procedures; the analysis and interpretation of data; the reporting of results; and, finally, the keeping of records. The chapter discusses each of these areas

  11. The impact of glaucoma on quality of life in Ethiopia: a case-control study.

    Science.gov (United States)

    Ayele, Fisseha A; Zeraye, Banchamelak; Assefa, Yared; Legesse, Kbrom; Azale, Telake; Burton, Matthew J

    2017-12-13

    Glaucoma is a chronic disease characterized by irreversible optic nerve damage and visual field loss that leads to visual impairment and blindness; ultimately limiting personal independence and compromising overall quality of life of affected individuals. There is paucity of information on how glaucoma affects the quality of life of patients in low and middle-income countries where resources for both diagnosis and treatment of such conditions are limited. In this study we investigate the impact of glaucoma on quality of life in Ethiopian patients. The quality of life of 307 glaucoma patients and 76 normal controls that were frequency matched to the age and sex profiles of the cases was assessed using Amharic version of Glaucoma Quality of Life -15 questionnaire. Linear regression models and the t-test were employed to compare significant differences in GQL-15 scores and to generate mean and mean differences between cases and controls respectively. The mean GQL-15 score in the glaucoma cases was substantially higher (indicating poorer quality of life) than the controls [cases 46.3 (95% CI, 28.8-63.8) and controls 18.6 (95% CI, 15.2-22.0), p glaucoma had significantly higher scores than the controls. Poorer quality of life was associated with age ≥ 71 years old 51.1 (95%CI, 26.2-75.9), rural residence 55.7 (95%CI, 49.9-61.5), monthly income of glaucoma (50.9; 95%CI, 43.6-58.3). These glaucoma patients, including those with normal visual acuity and early disease, had poorer quality of life compared to normal controls. Older age, rural residence, low income and more advanced disease were significantly associated with poorer quality of life. There is a need to increase awareness of the impact of glaucoma among clinicians, patients and their families, for a better understanding of the impact this disease has on a person's life.

  12. Quality control in radiotherapy

    International Nuclear Information System (INIS)

    Batalla, A.

    2009-01-01

    The authors discuss the modalities and periodicities of internal quality control on radiotherapy installations. They indicate the different concerned systems and the aspects and items to be controlled (patient and personnel security, apparatus mechanical characteristics, beam quality, image quality, isodose and irradiation duration calculation, data transfer). They present the measurement instruments and tools used for the mechanical controls, dose measurement, beam homogeneity and symmetry, anatomic data acquisition systems, and dose distribution and control imagery calculation

  13. Software product quality control

    CERN Document Server

    Wagner, Stefan

    2013-01-01

    Quality is not a fixed or universal property of software; it depends on the context and goals of its stakeholders. Hence, when you want to develop a high-quality software system, the first step must be a clear and precise specification of quality. Yet even if you get it right and complete, you can be sure that it will become invalid over time. So the only solution is continuous quality control: the steady and explicit evaluation of a product's properties with respect to its updated quality goals.This book guides you in setting up and running continuous quality control in your environment. Star

  14. Quality Market: Design and Field Study of Prediction Market for Software Quality Control

    Science.gov (United States)

    Krishnamurthy, Janaki

    2010-01-01

    Given the increasing competition in the software industry and the critical consequences of software errors, it has become important for companies to achieve high levels of software quality. While cost reduction and timeliness of projects continue to be important measures, software companies are placing increasing attention on identifying the user…

  15. DNA fingerprinting: a quality control case study for human biospecimen authentication.

    Science.gov (United States)

    Kofanova, Olga A; Mathieson, William; Thomas, Gerry A; Betsou, Fotini

    2014-04-01

    This case study illustrates the usefulness of the DNA fingerprinting method in biobank quality control (QC) procedures and emphasizes the need for detailed and accurate record keeping during processing of biological samples. It also underlines the value of independent third-party assessment to identify points at which errors are most likely to have occurred when unexpected results are obtained from biospecimens.

  16. Checking quality control?

    DEFF Research Database (Denmark)

    Brodersen, Lars

    2005-01-01

    How is quality control doing within the community of GIS, web-services based on geo-information, GI etc.?......How is quality control doing within the community of GIS, web-services based on geo-information, GI etc.?...

  17. Quality of life after iatrogenic bile duct injury: a case control study.

    LENUS (Irish Health Repository)

    Hogan, Aisling M

    2012-02-01

    OBJECTIVE: To compare quality of life (QOL) of patients following iatrogenic bile duct injuries (BDI) to matched controls. SUMMARY BACKGROUND DATA: BDI complicate approximately 0.3% of all cholecystectomy procedures. The literature regarding impact on quality of life is conflicted as assessment using clinical determinants alone is insufficient. METHODS: The medical outcomes study short form 36 (SF-36), a sensitive tool for quantification of life quality outcome, was used. The study group of iatrogenic BDI was compared with an age- and sex-matched group who underwent uncomplicated cholecystectomy. Telephone questionnaire using the SF-36 quality of life tool was administered to both groups at a median postoperative time of 12 years 8 months (range, 2 months -20 years). RESULTS: Seventy-eight patients were referred with BDI but due to mortality (n = 10) and unavailability (n = 6) 62 participated. The age- and sex-matched control cohort had undergone uncomplicated cholecystectomy (n = 62). Comparison between groups revealed that 7 of 8 variables examined were statistically similar to those of the control group (physical functioning, role physical, bodily pain, general health perceptions, vitality and social functioning, and mental health index). Mean role emotional scores were slightly worse in the BDI group (46 vs. 50) but the significance was borderline (P = 0.045). Subgroup analysis by method of intervention for BDI did not demonstrate significant differences. CONCLUSION: Quality of life of surviving patients following BDI compares favorably to that after uncomplicated laparoscopic cholecystectomy.

  18. Quality control and stability study of 100 mg/ml paracetamol oral drops

    International Nuclear Information System (INIS)

    Garcia Penna, Caridad M.; Montes de Oca Porto, Yanet; Salomon Izquierdo, Suslebys

    2013-01-01

    Paracetamol is an effective analgesic and antipyretic drug of the non-steroidal anti-inflammatory drug group. Paracetamol oral drops are indicated for use in infant population aged up to 5 years to relieve fever, headache, toothache and symptomatic relief of common cold. To validate two analytical methods for the quality control and the stability study and to study the stability of 100 mg/ml Paracetamol oral drops made in Cuba

  19. Sleep quality in patients with xerostomia: a prospective and randomized case-control study.

    Science.gov (United States)

    Lopez-Jornet, Pia; Lucero Berdugo, Maira; Fernandez-Pujante, Alba; C, Castillo Felipe; Lavella C, Zamora; A, Pons-Fuster; J, Silvestre Rangil; Silvestre, Francisco Javier

    2016-01-01

    Objectives To investigate sleep quality, anxiety/depression and quality-of-life in patients with xerostomia. Materials and methods This prospective, observational, cross-sectional study was conducted among a group of xerostomia patients (n = 30) compared with 30 matched control subjects. The following evaluation scales were used to assess the psychological profile of each patient: the Hospital Anxiety and Depression Scale, the Oral Health Impact Profile-14 (OHIP-14), the Xerostomia Inventory, the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS). Results The PSQI obtained 5.3 3 ± 1.78 for patients with xerostomia compared with 4.26 ± 1.01 for control subjects (p = 0.006); ESS obtained 5.7 ± 2.1 for test patients vs 4.4 0 ± 1 for control subjects (p = 0.010). Statistical regression analysis showed that xerostomia was significantly associated with depression (p = 0.027). Conclusions Patients with xerostomia exhibited significant decreases in sleep quality compared with control subjects.

  20. Quality control of radiopharmaceuticals

    International Nuclear Information System (INIS)

    Verdera, E.S.

    1994-01-01

    The quality control of radiopharmaceuticals is based in physics, physics-chemical and biological controls. Between the different controls can be enumerated the following: visual aspect,side, number of particle beams,activity,purity,ph,isotonicity,sterility,radioinmunoessay,toxicity,stability and clinical essay

  1. Quality Control in construction.

    Science.gov (United States)

    1984-01-01

    behavioral scientists. In 1962, Dr. Kaoru Ishikawa gave shape to the form of training which featured intradepartmental groups of ten or so workers seated...and Japanese circles bears closer scrutiny. 4.3.1 Japanese Ingredients of Quality The founder of quality circles, Dr. Kaoru Ishikawa , gives six...around 51 a table; hence the name Quality Control Circle. 4 Dr. 0 Ishikawa was an engineering professor at Tokyo University, and the circles were

  2. Performance of mechanical ventilators at the patient's home: a multicentre quality control study.

    Science.gov (United States)

    Farré, R; Navajas, D; Prats, E; Marti, S; Guell, R; Montserrat, J M; Tebe, C; Escarrabill, J

    2006-05-01

    Quality control procedures vary considerably among the providers of equipment for home mechanical ventilation (HMV). A multicentre quality control survey of HMV was performed at the home of 300 patients included in the HMV programmes of four hospitals in Barcelona. It consisted of three steps: (1) the prescribed ventilation settings, the actual settings in the ventilator control panel, and the actual performance of the ventilator measured at home were compared; (2) the different ventilator alarms were tested; and (3) the effect of differences between the prescribed settings and the actual performance of the ventilator on non-programmed readmissions of the patient was determined. Considerable differences were found between actual, set, and prescribed values of ventilator variables; these differences were similar in volume and pressure preset ventilators. The percentage of patients with a discrepancy between the prescribed and actual measured main ventilator variable (minute ventilation or inspiratory pressure) of more than 20% and 30% was 13% and 4%, respectively. The number of ventilators with built in alarms for power off, disconnection, or obstruction was 225, 280 and 157, respectively. These alarms did not work in two (0.9%), 52 (18.6%) and eight (5.1%) ventilators, respectively. The number of non-programmed hospital readmissions in the year before the study did not correlate with the index of ventilator error. This study illustrates the current limitations of the quality control of HMV and suggests that improvements should be made to ensure adequate ventilator settings and correct ventilator performance and ventilator alarm operation.

  3. Roadside air quality and implications for control measures: A case study of Hong Kong

    Science.gov (United States)

    Ai, Z. T.; Mak, C. M.; Lee, H. C.

    2016-07-01

    Traffic related air pollution is one of major environmental issues in densely populated urban areas including Hong Kong. A series of control measures has been implemented by Hong Kong government to cut traffic related air pollutants, including retrofitting the Euro II and Euro III buses with selective catalytic reduction (SCR) devices to lower nitrogen dioxide (NO2) emissions. In order to reveal the real-life roadside air quality and evaluate the effectiveness of the control measures, this study first analyzed the recent six-year data regarding concentrations of pollutants typically associated with traffic recorded in two governmental roadside monitoring stations and second conducted on-site measurements of concentration of pollutants at pedestrian level near five selected roads. Given that there is a possibility of ammonia leakage as a secondary pollutant from SCR devices, a special attention was paid to the measurements of ammonia level in bus stations and along roadsides. Important influencing factors, such as traffic intensity, street configuration and season, were analyzed. Control measures implemented by the government are effective to decrease the traffic emissions. In 2014, only NO2 cannot achieve the annual air quality objective of Hong Kong. However, it is important to find that particulate matters, rather than NO2, post potentially a short-term exposure risk to passengers and pedestrians. Based on the findings of this study, specific control measures are suggested, which are intended to further improve the roadside air quality.

  4. Intercalibration study. Net of quality control of waters of the Department of Antioquia

    International Nuclear Information System (INIS)

    Parra M, C.M; Mejia Z, G.M.

    1999-01-01

    The norm ISO 5725 has set a series of statistical procedures for the evaluation of results for an intercalibration study which of course is a fundamental support for the setting of a quality control program that must be implement by every laboratory seeking accreditation. In the present paper the implementation of such procedures is shown for an exercise classified to be as of a uniform level. The chosen parameter was suspended solids which is included in the fees of the retributive rates set by the Ministerio del Medio Ambiente in Colombia. The exercise was done by the laboratories that are members of the Analytical Control of Water Web in the Department of Antioquia

  5. Quality control of radiodiagnostics

    International Nuclear Information System (INIS)

    Alonso Diaz, M.; Castaneda Arronte, M.J.; Matorras Galan, P.; Diaz-Caneja Rodriguez, N.; Gutierrez Diaz Velarde, I.

    1993-01-01

    Since May 1990, a program of quality control of diagnostic X-ray equipment is underway in the University Hospital Marques de Valdecilla. This includes the design and application of measuring specifications and procedures corresponding to the different parameters of the equipment. The specified values are presented, as are those obtained for geometric and exposition parameters using the equipment. The specifications for the geometric parameters are fulfilled in an large proportion (between 52 and 86%) of the units, and the rest can easily be adjusted. However, 85% of the units can be made to operate with a field larger than that of the screen of the image monitor and approximately half of them can operate at a shorter focus-to-patient distance than that specified. With respect to the exposition parameters, in general, these units do not fulfill the specifications and their behavior is not uniform. The results obtained indicate that the equipment studied could be made to comply with the proposed specifications if a Maintenance Program were initiated in coordination with that of Quality Control. (Author)

  6. Quality control of radiopharmaceuticals

    International Nuclear Information System (INIS)

    Kristensen, K.

    1981-01-01

    Quality assurance was introduced in the pharmaceutical field long before it was used in many other areas, and the term quality control has been used in a much broader sense than merely analytical quality control. The term Good Manufacturing Practice (GMP) has been used to describe the system used for producing safe and effective drugs of a uniform quality. GMP has also been used for the industrial production of radiopharmaceuticals. For the preparation and control of radiopharmaceuticals in hospitals a similar system has been named Good Radiopharmacy Practice (GRP). It contains the same elements as GMP but takes into account the special nature of this group of drugs. Data on the assessment of the quality of radiopharmaceuticals in relation to present standards are reviewed. The general conclusion is that the quality of radiopharmaceuticals appears comparable to that of other drugs. It seems possible to establish the production of radiopharmaceuticals, generators and preparation kits in such a way that analytical control of the final product at the hospital may be limited provided the final preparation work is carried out in accordance with GRP principles. The elements of GRP are reviewed. (author)

  7. Results of quality control studies of technetium 99m labelled radiopharmaceuticals prepared from kits

    International Nuclear Information System (INIS)

    McLean, J.R.; Rockwell, L.J.; Welsh, W.J.

    1978-01-01

    This report summarizes the results of quality control studies of Tc 99m labelled normal serum albumin and macro-aggregated albumin radiopharmaceuticals prepared from commercially available kits. It includes all analyses performed since the inception of the program in 1976 until the end of 1977. The results presented herein were obtained through the application of various in vitro tests and animal (mouse) bio-distribution studies. It is hoped that a similar report will be published annually for the benefit of hospital nuclear medicine departments and kit manufacturers. (auth)

  8. Quality control and radioprotection in dental cone beam computed tomography - case study

    International Nuclear Information System (INIS)

    Rodrigues, Ligiane C.N.; Ferreira, Nadya M.P.D.

    2011-01-01

    The radiological protection in medical and odontologic radiology follows The Order (Portaria) 453/98 of the Ministry of Health, which presents the minimum set of tests for the constancy X-ray equipment. These tests follow the procedures set forth in the Resolution no. 64, the National Agency for Sanitary Vigilance. This work aims to show a study on dental cone beam computed tomography (CBCT), evaluating the physical parameters that influence the performance and image quality and presenting the appropriate tests to this new system. The authors analyzed the tests specific for computed tomography (CT) of the Resolution no. 64, feasibility assessment of them and if their interpretations are compatible with CBCT. Once determined if testing is feasible, compare with those presented in the manual provided by the equipment manufacturer. The CT scanner used was the Mini-Cat Tomography Scanner Xoran Technologies of KAVO. In the study it was verified that four tests could be reproduced in CBCT: noise, accuracy and uniformity in the number of CT of water and spatial resolution. Considering experimental data, the methodology and tolerance of manufacturer for the first two tests were more appropriate. For the uniformity test of the CT number, we recommend using the phantom quality control. Three new tests were suggested to be made in the quality control of the Cone Beam: linearity, artifacts and alignment of the beam. (author)

  9. Quality control and radioprotection in dental cone beam computed tomography - case study

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, Ligiane C.N.; Ferreira, Nadya M.P.D., E-mail: lnadya@ime.eb.br [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil)

    2011-07-01

    The radiological protection in medical and odontologic radiology follows The Order (Portaria) 453/98 of the Ministry of Health, which presents the minimum set of tests for the constancy X-ray equipment. These tests follow the procedures set forth in the Resolution no. 64, the National Agency for Sanitary Vigilance. This work aims to show a study on dental cone beam computed tomography (CBCT), evaluating the physical parameters that influence the performance and image quality and presenting the appropriate tests to this new system. The authors analyzed the tests specific for computed tomography (CT) of the Resolution no. 64, feasibility assessment of them and if their interpretations are compatible with CBCT. Once determined if testing is feasible, compare with those presented in the manual provided by the equipment manufacturer. The CT scanner used was the Mini-Cat Tomography Scanner Xoran Technologies of KAVO. In the study it was verified that four tests could be reproduced in CBCT: noise, accuracy and uniformity in the number of CT of water and spatial resolution. Considering experimental data, the methodology and tolerance of manufacturer for the first two tests were more appropriate. For the uniformity test of the CT number, we recommend using the phantom quality control. Three new tests were suggested to be made in the quality control of the Cone Beam: linearity, artifacts and alignment of the beam. (author)

  10. Quality control of dosemeters

    International Nuclear Information System (INIS)

    Mendes, L.

    1984-01-01

    Nuclear medicine laboratories are required to assay samples of radioactivity to be administered to patients. Almost universally, these assays are acomplished by use of a well ionization chamber isotope calibrator. The Instituto de Radioprotecao e Dosimetria (Institute for Radiological Protection and Dosimetry) of the Comissao Nacional de Energia Nuclear (National Commission for Nuclear Energy) is carrying out a National Quality Control Programme in Nuclear Medicine, supported by the International Atomic Energy Agency. The assessment of the current needs and practices of quality control in the entire country of Brazil includes Dose Calibrators and Scintilation Cameras, but this manual is restricted to the former. Quality Control Procedures for these Instruments are described in this document together with specific recommendations and assessment of its accuracy. (Author) [pt

  11. Effect of yoga on quality of life of CLBP patients: A randomized control study

    Directory of Open Access Journals (Sweden)

    Tekur Padmini

    2010-01-01

    Full Text Available Context: In two of the earlier Randomized Control Trials on yoga for chronic lower back pain (CLBP, 12 to 16 weeks of intervention were found effective in reducing pain and disability. Aim: To study the efficacy of a residential short term intensive yoga program on quality of life in CLBP. Materials and Methods: About 80 patients with CLBP (females 37 registered for a week long treatment at SVYASA Holistic Health Centre in Bengaluru, India. They were randomized into two groups (40 each. The yoga group practiced a specific module for CLBP comprising of asanas (physical postures, pranayama (breathing practices, meditation and lectures on yoga philosophy. The control group practiced physical therapy exercises for back pain. Perceived stress scale (PSS was used to measure baseline stress levels. Outcome measures were WHOQOL Bref for quality of life and straight leg raising test (SLR using a Goniometer. Results: There were significant negative correlations (Pearson′s, P<0.005, r>0.30 between baseline PSS with all four domains and the total score of WHOQOLBref. All the four domains′ WHOQOLBref improved in the yoga group (repeated measures ANOVA P=0.001 with significant groupFNx01time interaction (P<0.05 and differences between groups (P<0.01. SLR increased in both groups (P=0.001 with higher increase in yoga (31.1 % right, 28.4 % left than control (18.7% right, 21.5 % left group with significant groupFNx01time interaction (SLR right leg P=0.044. Conclusion: In CLBP, a negative correlation exists between stress and quality of life. Yoga increases quality of life and spinal flexibility better than physical therapy exercises.

  12. A hard day's night : a longitudinal study on the relationships among job demands and job control, sleep quality and fatigue

    NARCIS (Netherlands)

    De Lange, Annet H.; Kompier, Michiel A. J.; Taris, Toon W.; Geurts, Sabine A. E.; Beckers, Debby G. J.; Houtman, Irene L. D.; Bongers, Paulien M.

    This prospective four-wave study examined (i) the causal direction of the longitudinal relations among job demands, job control, sleep quality and fatigue; and (ii) the effects of stability and change in demand-control history on the development of sleep quality and fatigue. Based on results of a

  13. A hard day's night: a longitudinal study on the relationships among job demands and job control, sleep quality and fatigue

    NARCIS (Netherlands)

    Lange, A.H. de; Kompier, M.A.J.; Taris, T.W.; Geurts, S.A.E.; Beckers, D.G.J.; Houtman, I.L.D.; Bongers, P.M.

    2009-01-01

    This prospective four-wave study examined (i) the causal direction of the longitudinal relations among job demands, job control, sleep quality and fatigue; and (ii) the effects of stability and change in demand-control history on the development of sleep quality and fatigue. Based on results of a

  14. A hard day's night: a longitudinal study on the relationships among job demands and job control, sleep quality and fatigue

    NARCIS (Netherlands)

    de Lange, A.H.; Kompier, M.A.J.; Taris, T.W.; Geurts, S.A.E.; Beckers, D.G.J.; Houtman, I.L.H.; Bongers, P.M.

    2009-01-01

    Summary This prospective four-wave study examined (i) the causal direction of the longitudinal relations among job demands, job control, sleep quality and fatigue; and (ii) the effects of stability and change in demand-control history on the development of sleep quality and fatigue. Based on results

  15. A hard day's night: A longitudinal study on the relationships among job demands and job control, sleep quality and fatigue

    NARCIS (Netherlands)

    Lange, A.H.de; Kompier, M.A.J.; Taris, T.W.; Geurts, S.A.E.; Beckers, D.G.J.; Houtman, I.L.D.; Bongers, P.M.

    2009-01-01

    This prospective four-wave study examined (i) the causal direction of the longitudinal relations among job demands, job control, sleep quality and fatigue; and (ii) the effects of stability and change in demand-control history on the development of sleep quality and fatigue. Based on results of a

  16. Quality Management, Quality Assurance and Quality Control in Blood Establishments

    OpenAIRE

    Bolbate, N

    2008-01-01

    Quality terms and the roots of the matter are analyzed according to European Committee’s recommendations. Essence of process and product quality control as well as essence of quality assurance is described. Quality system’s structure including quality control, quality assurance and management is justified in the article.

  17. Quality control in haemostasis.

    Science.gov (United States)

    Capel, P; Chatelain, B; Leclerq, R; Lust, A; Masure, R; Arnout, J

    1992-01-01

    Laboratory investigation of the haemostatic system deserves particular procedures in the quality control of analytical variables as well as preanalytical variables. This paper reviews the precautions that have to be taken in the blood prelevement, the transport of the tubes and the performance of the laboratory tests aimed to investigate the haemostatic system in order to obtain reliable results.

  18. Ocean Data Quality Control

    Science.gov (United States)

    2011-11-18

    the aero- sol at the coincident time and location of the satellite SST retrievals. This informa- tion is available in the daytime for the anti-solar...are of the same form, such as probabilities or standard normal deviates. A quality control decision-making algorithm in use at the U.S. Navy oceano

  19. Preparation and quality control of radiolabelled cobalt-57 bleomycins for oncological studies

    International Nuclear Information System (INIS)

    Jalilian, A. R.; Rowshanfarzad, P.; Moafian, J.; Ensaf, M. R.; Sabet, M.

    2007-01-01

    [ 55 Co] bleomycin has been widely used in ontological studies. Due to relative short half life of cobalt-55, optimization and feasibility studies for determination of the best labeling conditions is preferably performed using cobalt-57. In this study, the optimization of complexation conditions for time, temperature and ligand concentration were performed. The best labeling yield was obtained at room temperature in pH of 4-7, using 0.4 mCi of 57 CoCl 2 with 0.3mg of BLM in 30 minutes. The final radiopharmaceutical solution underwent common quality control tests, validating our future studies for animal scanning studies using [ 55 Co]bleomycin complex

  20. Integrated multi-level quality control for proteomic profiling studies using mass spectrometry

    Directory of Open Access Journals (Sweden)

    Barrett Jennifer H

    2008-12-01

    Full Text Available Abstract Background Proteomic profiling using mass spectrometry (MS is one of the most promising methods for the analysis of complex biological samples such as urine, serum and tissue for biomarker discovery. Such experiments are often conducted using MALDI-TOF (matrix-assisted laser desorption/ionisation time-of-flight and SELDI-TOF (surface-enhanced laser desorption/ionisation time-of-flight MS. Using such profiling methods it is possible to identify changes in protein expression that differentiate disease states and individual proteins or patterns that may be useful as potential biomarkers. However, the incorporation of quality control (QC processes that allow the identification of low quality spectra reliably and hence allow the removal of such data before further analysis is often overlooked. In this paper we describe rigorous methods for the assessment of quality of spectral data. These procedures are presented in a user-friendly, web-based program. The data obtained post-QC is then examined using variance components analysis to quantify the amount of variance due to some of the factors in the experimental design. Results Using data from a SELDI profiling study of serum from patients with different levels of renal function, we show how the algorithms described in this paper may be used to detect systematic variability within and between sample replicates, pooled samples and SELDI chips and spots. Manual inspection of those spectral data that were identified as being of poor quality confirmed the efficacy of the algorithms. Variance components analysis demonstrated the relatively small amount of technical variance attributable to day of profile generation and experimental array. Conclusion Using the techniques described in this paper it is possible to reliably detect poor quality data within proteomic profiling experiments undertaken by MS. The removal of these spectra at the initial stages of the analysis substantially improves the

  1. VGI QUALITY CONTROL

    Directory of Open Access Journals (Sweden)

    C. C. Fonte

    2015-08-01

    Full Text Available This paper presents a framework for considering quality control of volunteered geographic information (VGI. Different issues need to be considered during the conception, acquisition and post-acquisition phases of VGI creation. This includes items such as collecting metadata on the volunteer, providing suitable training, giving corrective feedback during the mapping process and use of control data, among others. Two examples of VGI data collection are then considered with respect to this quality control framework, i.e. VGI data collection by National Mapping Agencies and by the most recent Geo-Wiki tool, a game called Cropland Capture. Although good practices are beginning to emerge, there is still the need for the development and sharing of best practice, especially if VGI is to be integrated with authoritative map products or used for calibration and/or validation of land cover in the future.

  2. Internal quality control of PCR-based genotyping methods in research studies and patient diagnostics

    DEFF Research Database (Denmark)

    Bladbjerg, Else-Marie; Gram, Jørgen; Jespersen, Jørgen

    2002-01-01

    Genetic analyses are increasingly integrated in the clinical laboratory, and internal quality control programmes are needed. We have focused on quality control aspects of selected polymorphism analyses used in thrombosis research. DNA was isolated from EDTA-blood (n = 500) by ammonium acetate....... Control of data handling revealed 0.1% reading mistakes and 0.5% entry mistakes. Based on our experiences we propose an internal quality control programme for widely used PCR-based haemostasis polymorphism analyses.......-isolation (pre-analytical factors), DNA-amplification, digestion with restriction enzymes, electrophoresis (analytical factors), result reading and entry into a database (post-analytical factors). Furthermore, we evaluated a procedure for result confirmation. Isolated DNA was of good quality (42 microg/ml blood...

  3. Radioisotopic methods for quality control of works and studies while constructing foundations and underground structures

    International Nuclear Information System (INIS)

    Smorodinov, M.I.

    1980-01-01

    The data on the use of radioisotope methods of quality control of various kinds of construction works when building foundations and underground constructions and when carrying out scientific research, are presented. Devices and equipment are described, their block diagrams are presented. The experience in using radioisotope devices to control the quality of construction works, is presented. The problems of economic effectivenes of works using radioisotope devices are solved

  4. SAQC: SNP Array Quality Control

    Directory of Open Access Journals (Sweden)

    Li Ling-Hui

    2011-04-01

    Full Text Available Abstract Background Genome-wide single-nucleotide polymorphism (SNP arrays containing hundreds of thousands of SNPs from the human genome have proven useful for studying important human genome questions. Data quality of SNP arrays plays a key role in the accuracy and precision of downstream data analyses. However, good indices for assessing data quality of SNP arrays have not yet been developed. Results We developed new quality indices to measure the quality of SNP arrays and/or DNA samples and investigated their statistical properties. The indices quantify a departure of estimated individual-level allele frequencies (AFs from expected frequencies via standardized distances. The proposed quality indices followed lognormal distributions in several large genomic studies that we empirically evaluated. AF reference data and quality index reference data for different SNP array platforms were established based on samples from various reference populations. Furthermore, a confidence interval method based on the underlying empirical distributions of quality indices was developed to identify poor-quality SNP arrays and/or DNA samples. Analyses of authentic biological data and simulated data show that this new method is sensitive and specific for the detection of poor-quality SNP arrays and/or DNA samples. Conclusions This study introduces new quality indices, establishes references for AFs and quality indices, and develops a detection method for poor-quality SNP arrays and/or DNA samples. We have developed a new computer program that utilizes these methods called SNP Array Quality Control (SAQC. SAQC software is written in R and R-GUI and was developed as a user-friendly tool for the visualization and evaluation of data quality of genome-wide SNP arrays. The program is available online (http://www.stat.sinica.edu.tw/hsinchou/genetics/quality/SAQC.htm.

  5. Frontiers in statistical quality control

    CERN Document Server

    Wilrich, Peter-Theodor

    2001-01-01

    The book is a collection of papers presented at the 5th International Workshop on Intelligent Statistical Quality Control in Würzburg, Germany. Contributions deal with methodology and successful industrial applications. They can be grouped in four catagories: Sampling Inspection, Statistical Process Control, Data Analysis and Process Capability Studies and Experimental Design.

  6. Dosimetry and Image Quality in Control Studies in Computerised Tomography Realized to Paediatric Patients

    International Nuclear Information System (INIS)

    Hernandez, M. R.; Gamboa-deBuen, I.; Dies, P.; Rickards, J.; Ruiz, C.

    2008-01-01

    Computerised tomography (CT) is a favourite method of medical diagnosis. Its use has thus increased rapidly throughout the world, particularly in studies relating to children. However to avoid administering unnecessarily high doses of radiation to paediatric patients it is important to have correct dose reference levels to minimize risk. The research is being developed within the public health sector at the Hospital Infantil de Mexico ''Dr. Federico Gomez.'' We measured the entrance surface air kerma (K P ) in paediatric patients, during the radiological studies of control in CT (studies of head, thorax and abdomen). Phantom was used to evaluate image quality as the tomograph requires a high resolution image in order to operate at its optimum level

  7. Quality control of mammography

    International Nuclear Information System (INIS)

    Hering, K.G.

    1986-01-01

    Random checks of mammograms allow to clearly assess quality controls concerning correct application and operation of the radiographic system indicated by rich contrast in breast tissue images, complete imaging of the mammary parenchyma, freedom from blurs due to motion, efficient breast compression, correct film labelling and perfect maintenance of the film screen system. In addition to these subjective assessments, the following points should be considered when using objective measurement procedures and phantoms: Testing the correct function of X-ray and radiographic equipment by means of test specimens to measure KV standard (KV=Association of German Panel Doctors), mAS and automatic exposure timer; comparing dose and density to initial values and checking film processing by using a sensitometer. Quality assurance handling varies from one KV to the next. That is why the users need to obtain the guidelines of the respective KV relative to radiological quality assurance and to proceed according to these. (orig.) [de

  8. Quality control aspects of herbs and botanicals in developing countries: Coleus forskohlii Briq a case study

    Directory of Open Access Journals (Sweden)

    Ennus Tajuddin Tamboli

    2015-01-01

    Full Text Available Objective: Current trend of commercialization of herbal medicines draw a huge need of maintaining their quality. The declaration of quality, safety and efficacy of medicinal plants as well as poly-herbal formulations has become an important issue. Hence, qualitative and quantitative analysis of herbal drugs and formulations viz., fingerprint profiles and quantification of the various markers become key factors of quality control. Materials and Methods: Present investigation is a detailed report for quality control of well-known herb Coleus forskohlii Briq, which includes physicochemical parameter determination, safety evaluation, microscropical evaluation, and chromatographic fingerprinting as well. Results: Physico-chemical characters were evaluated according to Indian Pharmacopoeia, further microscopic evaluation of transverse section of Coleus reveals that periderm, secondary phloem, and wide secondary xylem cylinder, which occupies major portion of the root fragmentary. Chromatographic fingerprint profiles of Coleus have been generated, and a marker based standardization strategy was adopted; using different analytical technique like high-performance thin layer chromatography, high-performance liquid chromatography and gas chromatography-mass spectroscopy to maintain quality and ensure safety as well as efficacy. Conclusion: These advancements in modern techniques of analysis can lead to effective quality control of Coleus as well as other herbs. Present report can act as pioneer for quality control of modern herbal medicine.

  9. Quality assurance programme and quality control

    International Nuclear Information System (INIS)

    Alvarez de Buergo, L.

    1979-01-01

    The paper analyses the requirements for the quality assurance and control in nuclear power plant projects which are needed to achieve safe, reliable and economic plants. The author describes the structure for the establishment of a nuclear programme at the national level and the participation of the different bodies involved in a nuclear power plant project. The paper ends with the study of a specific case in Spain. (NEA) [fr

  10. Analytical method validation for quality control and the study of the 50 mg Propylthiouracil stability

    International Nuclear Information System (INIS)

    Valdes Bendoyro, Maria Olga; Garcia Penna, Caridad Margarita; Fernandez, Juan Lugones; Garcia Borges, Lisandra; Martinez Espinosa, Vivian

    2010-01-01

    A high-performance liquid chromatography analytical method was developed and validated for the quality control and stability studies of 50 mg Propylthiouracil tablets. Method is based in active principle separation through a 100 RP-18 RP-18 (5 μm) (250 x 4 mm) Lichrospher chromatography with UV detection to 272 nm, using a mobile phase composed by a ungaseous mixture of a 0.025 M buffer solution-monobasic potassium phosphate to pH= 4,6 ad acetonitrile in a 80:20 ratio with a flux speed of 0,5 mL/min. Analytical method was linear, precise, specific and exact in the study concentrations interval

  11. Health-related quality of life among children with Turner syndrome: controlled cross-sectional study.

    Science.gov (United States)

    Amedro, Pascal; Tahhan, Nabil; Bertet, Helena; Jeandel, Claire; Guillaumont, Sophie; Mura, Thibault; Picot, Marie-Christine

    2017-08-28

    The aim of the study was to assess health-related quality of life (HR-QoL) in children with Turner syndrome in comparison with controls. We prospectively recruited 16 female girls with Turner syndrome (mean age 15.2±2.6 years) and 78 female controls (mean age 12.7±2.8 years) in randomly selected schools. We used the PedsQL, a generic HR-QoL questionnaire (self and parents' versions). Global HR-QoL scores in Turner syndrome were lower than controls for self-reports (respectively, 74.3±3.0 vs. 82.8±1.3, p=0.01) and parents' reports (62.7±3.8 vs. 80.1±1.7, pTurner syndrome, self-reported HR-QoL was impaired in school functioning (70.6±4.0 vs. 80.71±1.7, p=0.02), social functioning (78.2±4.0 vs. 90.4±1.8, pTurner syndrome, as in previously reported adult studies. In addition to medical treatment and routine clinical follow-up, female girls and teenagers with Turner syndrome should also be supported psychologically by social, educational and psychotherapeutic interventions that aim to address their self-esteem and emotional difficulties.

  12. Results of quality control studies of technetium 99m labelled radiopharmaceuticals prepared from kits (1980-81)

    International Nuclear Information System (INIS)

    1983-01-01

    This report summarized the results of quality control studies of Tc 99m labelled human serum albumin, macroaggregated albumin, bone imaging and reticuloendothelial system imaging radiopharmaceuticals prepared from commercially available kits. It includes all analyses performed from January 1980 to December 1981 by the radiopharmaceutical quality control section of the Radiation Protection Bureau. These results were obtained by the application of various in vitro and animal (mouse) biodistribution studies

  13. The Impact of Trachomatous Trichiasis on Quality of Life: A Case Control Study.

    Directory of Open Access Journals (Sweden)

    Esmael Habtamu

    2015-11-01

    Full Text Available Trachomatous trichiasis is thought to have a profound effect on quality of life (QoL, however, there is little research in this area. We measured vision and health-related QoL in a case-control study in Amhara Region, Ethiopia.We recruited 1000 adult trichiasis cases and 200 trichiasis-free controls, matched to every fifth trichiasis case on age (+/- two years, sex and location. Vision-related quality of life (VRQoL and health-related quality of life (HRQoL were measured using the WHO/PBD-VF20 and WHOQOL-BREF questionnaires. Comparisons were made using linear regression adjusted for age, sex and socioeconomic status. Trichiasis cases had substantially lower VRQoL than controls on all subscales (overall eyesight, visual symptom, general functioning and psychosocial, p<0.0001, even in the sub-group with normal vision (p<0.0001. Lower VRQoL scores in cases were associated with longer trichiasis duration, central corneal opacity, visual impairment and poor contrast sensitivity. Trichiasis cases had lower HRQoL in all domains (Physical-health, Psychological, Social, Environment, p<0.0001, lower overall QoL (mean, 34.5 v 64.6; p<0.0001 and overall health satisfaction (mean, 38.2 v 71.7; p<0.0001. This association persisted in a sub-group analysis of cases and controls with normal vision. Not having a marriage partner (p<0.0001, visual impairment (p = 0.0068, daily labouring (p<0.0001, presence of other health problems (p = 0.0018 and low self-rated wealth (p<0.0001 were independently associated with lower overall QoL scores in cases. Among cases, trichiasis caused 596 (59% to feel embarrassed, 913 (91.3% to worry they may lose their remaining eyesight and 681 (68.1% to have sleep disturbance.Trachomatous trichiasis substantially reduces vision and health related QoL and is disabling, even without visual impairment. Prompt trichiasis intervention is needed both to prevent vision loss and to alleviate physical and psychological suffering, social

  14. Oral health-related quality of life in Iranian patients with spinal cord injury: a case-control study

    NARCIS (Netherlands)

    Pakpour, A.H.; Kumar, S.; Scheerman, J.F.M.; Lin, C.Y.; Fridlund, B.; Jansson, H.

    2016-01-01

    Introduction: The study aimed to compare the oral health variables, general, and oral health-related quality of life (QoL), depression, and anxiety between spinal cord injury (SCI) patients and healthy controls and also to determine the key factors related to the oral health-related quality of life

  15. Fragrance allergy and quality of life - a case-control study.

    Science.gov (United States)

    Heisterberg, Maria V; Menné, Torkil; Johansen, Jeanne D

    2014-02-01

    Fragrance ingredients can cause contact allergy, which may affect quality of life (QoL). However, few studies have investigated this topic. To investigate QoL life among subjects with a fragrance allergy as compared with other eczema patients. A case-control survey was sent to subjects with a positive patch test reaction to a fragrance ingredient/marker (n = 550) and to a control group (n = 1100). It contained questions on eczema and the newly developed fragrance QoL index. Participants had been consecutively patch tested at Gentofte University Hospital (2000-2010). The response rate was 65.7%. Information on patch test data was retrieved from the National Contact Dermatitis Database. An increase in impairment of QoL was observed in women with fragrance allergy as compared with the control group (p = 0.042), which was not found among men. Several factors played a significant role in impairment of QoL in women: (i) number of fragrance allergies, (ii) severity of the patch test reaction, (iii) age combined with recent diagnosis; and (iv) allergy to specific fragrance ingredients/markers. Fragrance-allergic subjects are just as affected in their QoL as other eczema patients. However, women, and in particular recently diagnosed young women, seem to be more impaired in their QoL than other eczema patients. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  16. Quality Control - Nike.Inc

    OpenAIRE

    Walter G. Bishop

    2017-01-01

    The purpose of this paper is to present the illustration of quality control approach, which has been adopted by several organizations, in order to manage and improve their production processes. The approach is referred as total quality management (TQM). This study will discuss the implementation of TQ, within the working environment of Nike Inc. One of the major objectives behind the implementation of TQ is to reduce or completely eliminate potential errors and flaws, within the manufacturing...

  17. Methodological and Reporting Quality of Comparative Studies Evaluating Health-Related Quality of Life of Colorectal Cancer Patients and Controls: A Systematic Review.

    Science.gov (United States)

    Wong, Carlos K H; Guo, Vivian Y W; Chen, Jing; Lam, Cindy L K

    2016-11-01

    Health-related quality of life is an important outcome measure in patients with colorectal cancer. Comparison with normative data has been increasingly undertaken to assess the additional impact of colorectal cancer on health-related quality of life. This review aimed to critically appraise the methodological details and reporting characteristics of comparative studies evaluating differences in health-related quality of life between patients and controls. A systematic search of English-language literature published between January 1985 and May 2014 was conducted through a database search of PubMed, Web of Science, Embase, and Medline. Comparative studies reporting health-related quality-of-life outcomes among patients who have colorectal cancer and controls were selected. Methodological and reporting quality per comparison study was evaluated based on a 11-item methodological checklist proposed by Efficace in 2003 and a set of criteria predetermined by reviewers. Thirty-one comparative studies involving >10,000 patients and >10,000 controls were included. Twenty-three studies (74.2%) originated from European countries, with the largest number from the Netherlands (n = 6). Twenty-eight studies (90.3%) compared the health-related quality of life of patients with normative data published elsewhere, whereas the remaining studies recruited a group of patients who had colorectal cancer and a group of control patients within the same studies. The European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire Core 30 was the most extensively used instrument (n = 16; 51.6%). Eight studies (25.8%) were classified as "probably robust" for clinical decision making according to the Efficace standard methodological checklist. Our further quality assessment revealed the lack of score differences reported (61.3%), contemporary comparisons (36.7%), statistical significance tested (38.7%), and matching of control group (58.1%), possibly leading to

  18. Quality of life after surgery for intractable partial epilepsy in children: a cohort study with controls.

    Science.gov (United States)

    Mikati, Mohamad A; Ataya, Nour; Ferzli, Jessica; Kurdi, Rana; El-Banna, Diana; Rahi, Amal; Shamseddine, Alhan; Sinno, Durriyah; Comair, Youssef

    2010-08-01

    Investigate if quality of life (QOL) normalizes on long-term follow-up after surgery for partial epilepsy in children. This is a cohort study with controls in which a consecutive cohort of nineteen 2-14-year-old children who underwent focal resections for intractable partial seizures between 1996 and 2006, were matched with 19 non-surgery intractable partial epilepsy patients, and with 19 healthy subjects. The two epilepsy groups were matched for age, sex, socio-economic status (SES), cognitive level, seizure type, and seizure frequency. The healthy group was matched with the two epilepsy groups for age, sex, SES, and cognitive level. QOL was assessed using the QOLCE (Quality of Life in Childhood Epilepsy Questionnaire). In the surgery group (follow-up 3.84+/-2.26 years), 78.9% had Engel class-I versus 21.1% in non-surgery (p=0.01) (follow-up 3.44+/-2.95 years). Surgery patients were similar to healthy subjects in the social, emotional, cognitive, behavioral, and overall QOL (p>0.05) but had lower scores in the total QOL, physical, and health domains (p0.05, power>0.8). Our data indicate that epilepsy surgery for partial seizures in children is associated with better QOL as compared to children with intractable epilepsy who are not operated on, and suggest that in those who achieve seizure freedom normal QOL may at least potentially be possible.

  19. Feasibility study of using statistical process control to customized quality assurance in proton therapy.

    Science.gov (United States)

    Rah, Jeong-Eun; Shin, Dongho; Oh, Do Hoon; Kim, Tae Hyun; Kim, Gwe-Ya

    2014-09-01

    To evaluate and improve the reliability of proton quality assurance (QA) processes and, to provide an optimal customized tolerance level using the statistical process control (SPC) methodology. The authors investigated the consistency check of dose per monitor unit (D/MU) and range in proton beams to see whether it was within the tolerance level of the daily QA process. This study analyzed the difference between the measured and calculated ranges along the central axis to improve the patient-specific QA process in proton beams by using process capability indices. The authors established a customized tolerance level of ±2% for D/MU and ±0.5 mm for beam range in the daily proton QA process. In the authors' analysis of the process capability indices, the patient-specific range measurements were capable of a specification limit of ±2% in clinical plans. SPC methodology is a useful tool for customizing the optimal QA tolerance levels and improving the quality of proton machine maintenance, treatment delivery, and ultimately patient safety.

  20. Feasibility study of using statistical process control to customized quality assurance in proton therapy

    International Nuclear Information System (INIS)

    Rah, Jeong-Eun; Oh, Do Hoon; Shin, Dongho; Kim, Tae Hyun; Kim, Gwe-Ya

    2014-01-01

    Purpose: To evaluate and improve the reliability of proton quality assurance (QA) processes and, to provide an optimal customized tolerance level using the statistical process control (SPC) methodology. Methods: The authors investigated the consistency check of dose per monitor unit (D/MU) and range in proton beams to see whether it was within the tolerance level of the daily QA process. This study analyzed the difference between the measured and calculated ranges along the central axis to improve the patient-specific QA process in proton beams by using process capability indices. Results: The authors established a customized tolerance level of ±2% for D/MU and ±0.5 mm for beam range in the daily proton QA process. In the authors’ analysis of the process capability indices, the patient-specific range measurements were capable of a specification limit of ±2% in clinical plans. Conclusions: SPC methodology is a useful tool for customizing the optimal QA tolerance levels and improving the quality of proton machine maintenance, treatment delivery, and ultimately patient safety

  1. SQC: secure quality control for meta-analysis of genome-wide association studies.

    Science.gov (United States)

    Huang, Zhicong; Lin, Huang; Fellay, Jacques; Kutalik, Zoltán; Hubaux, Jean-Pierre

    2017-08-01

    Due to the limited power of small-scale genome-wide association studies (GWAS), researchers tend to collaborate and establish a larger consortium in order to perform large-scale GWAS. Genome-wide association meta-analysis (GWAMA) is a statistical tool that aims to synthesize results from multiple independent studies to increase the statistical power and reduce false-positive findings of GWAS. However, it has been demonstrated that the aggregate data of individual studies are subject to inference attacks, hence privacy concerns arise when researchers share study data in GWAMA. In this article, we propose a secure quality control (SQC) protocol, which enables checking the quality of data in a privacy-preserving way without revealing sensitive information to a potential adversary. SQC employs state-of-the-art cryptographic and statistical techniques for privacy protection. We implement the solution in a meta-analysis pipeline with real data to demonstrate the efficiency and scalability on commodity machines. The distributed execution of SQC on a cluster of 128 cores for one million genetic variants takes less than one hour, which is a modest cost considering the 10-month time span usually observed for the completion of the QC procedure that includes timing of logistics. SQC is implemented in Java and is publicly available at https://github.com/acs6610987/secureqc. jean-pierre.hubaux@epfl.ch. Supplementary data are available at Bioinformatics online. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  2. Organizing quality control programmes

    International Nuclear Information System (INIS)

    Hjardemaal, O.

    1989-01-01

    When procuring new equipment, performance and safety should be specified, if possible by reference to international standards. Some of the characteristics of the International Electrotechnical Commission (IEC) standard for X-ray generators, in particular the accuracy of the operating data, are described. The quality control tests to be performed after installation comprise acceptance test, status test and constancy test. The first two involve absolute measurements and will be the responsibility of physicists or engineers. Apparently limiting values stipulated by users are a factor of two lower than the limits of the IEC standard. By means of an example it is shown that modern X-ray generators can meet the lower limits of the users without problems. In order to obtain optimum initial quality when procuring new equipment operating data, limiting values must be specified and must be verified by acceptance testing, etc. However, in many countries physicists and engineers are not available for this job. A relatively uncomplicated test object can be used by radiographers for checks on fluoroscopic systems. The findings from such tests in Denmark are compared with other published findings and good agreement is found. Therefore it is proposed that such uncomplicated tests could form the basis for quality evaluation. (author)

  3. [Fitness and quality of life in kidney transplant recipients: case-control study].

    Science.gov (United States)

    Hernández Sánchez, Sonsoles; Carrero, Juan J; García López, David; Herrero Alonso, Juan Azael; Menéndez Alegre, Héctor; Ruiz, Jonatan R

    2016-04-15

    We analyzed the levels of fitness, muscle structure and quality of life of adults after kidney transplant and healthy adults. A total of 16 kidney transplant patients and 21 healthy controls performed several fitness test, isokinetic evaluation of knee flexion and extension and ultrasonography muscle thickness assessment. They also completed the quality of life questionnaire SF-36. Physical fitness, muscle structure and quality of life of the kidney transplant recipients were significantly poorer than the controls. The transplant patients performed less well in the "get up and go" and "sit to stand" test (p<.001) as well as in assessments of muscle structure, strength and power. The patients had a poorer score in their quality of life assessments, differing from the controls in domains of physical function, physical role, general health and social function (p<.001). Fitness, strength and muscle mass are diminished in kidney transplant patients, resulting in a poorer quality of life which might entail an increased risk to their health. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  4. Earth Observation Data Quality Monitoring and Control: A Case Study of STAR Central Data Repository

    Science.gov (United States)

    Han, W.; Jochum, M.

    2017-12-01

    Earth observation data quality is very important for researchers and decision makers involved in weather forecasting, severe weather warning, disaster and emergency response, environmental monitoring, etc. Monitoring and control earth observation data quality, especially accuracy, completeness, and timeliness, is very useful in data management and governance to optimize data flow, discover potential transmission issues, and better connect data providers and users. Taking a centralized near real-time satellite data repository, STAR (Center for Satellite Applications and Research of NOAA) Central Data Repository (SCDR), as an example, this paper describes how to develop new mechanism to verify data integrity, check data completeness, and monitor data latency in an operational data management system. Such quality monitoring and control of large volume satellite data help data providers and managers improve data transmission of near real-time satellite data, enhance its acquisition and management, and overcome performance and management issues to better serve research and development activities.

  5. Study on the internal quality control of thyroid hormones assays in a hospital laboratory

    International Nuclear Information System (INIS)

    Hu Haiqiang; Chu Shaolin; Ye Peihong; Lei Qiufang; Chai Luhua; Xia Wei

    2004-01-01

    Objective: With the aim of providing more reliable information for clinical diagnosis, this study investigated the possible causes of the occasional instability of thyroid hormones (T 3 , T 4 , FT 3 , FT 4 TSH) assays in this laboratory and tried to seek plausible explanation for some seemingly contradictory (mismatching) readings of the laboratory reports. Methods: Regular monitoring and checks were enforced on laboratory equipment from sampling pipet to gamma-counters. Results of separation with PR reagent and solid - phase coated tube were compared for superiority (FT 3 ). Collected specimens were tested in monthly sets; this study consisted of 10 sets with total 964 specimens. Serum T 3 , T 4 , FT 3 , FT 4 levels were measured with RIA. For every hormone tested, values of parameters of the standard cure (B 0 , NSB, a, b, r, ED 20 , ED 50 , ED 80 , ABCV) were recorded in detail, from which the QC (quality control) table was derived. For complementary sake , mean level in patients' sera was noted along with the quality control sera. Shewart control chart was drawn for quick reference. Serum TSH levels were measured with IRMA; the parameters involved were: B 0 NSB, ED 80 , ED 50 , ED 20 , standard point deviation. Results: Among the 964 specimens tested, there were 154 specimens with seemingly contradictory (mismatching) results, of which, the majority (n=145) were not erroneous and were compatible with the clinical manifestations of thyroid dysfunction other than plain simple hyper-or hypothyroidism. Only 9 (5.8% of the 154) were due to technical errors (defective technic in removing the supernatant n=7, lipid blood separated with PR reagent n=2). Conclusion: Faulty technic in separation is the main source of random error. From the data of this laboratory, authors believe that solid-phase separation method is better than the conventional homogenous-phase separation method and is the preferred one. With meticulous adherence to standard laboratory procedures and

  6. A Quality Control study of the distribution of NOAA MIRS Cloudy retrievals during Hurricane Sandy

    Science.gov (United States)

    Fletcher, S. J.

    2013-12-01

    Cloudy radiance present a difficult challenge to data assimilation (DA) systems, through both the radiative transfer system as well the hydrometers required to resolve the cloud and precipitation. In most DA systems the hydrometers are not control variables due to many limitations. The National Oceanic and Atmospheric Administration's (NOAA) Microwave Integrated Retrieval System (MIRS) is producing products from the NPP-ATMS satellite where the scene is cloud and precipitation affected. The test case that we present here is the life time of Hurricane and then Superstorm Sandy in October 2012. As a quality control study we shall compare the retrieved water vapor content during the lifetime of Sandy with the first guess and the analysis from the NOAA Gridpoint Statistical Interpolation (GSI) system. The assessment involves the gross error check system against the first guess with different values for the observational error's variance to see if the difference is within three standard deviations. We shall also compare against the final analysis at the relevant cycles to see if the products which have been retrieved through a cloudy radiance are similar, given that the DA system does not assimilate cloudy radiances yet.

  7. Frontiers in statistical quality control

    CERN Document Server

    Wilrich, Peter-Theodor

    1997-01-01

    Like the preceding volumes, and met with a lively response, the present volume is collecting contributions stressed on methodology or successful industrial applications. The papers are classified under four main headings: sampling inspection, process quality control, data analysis and process capability studies and finally experimental design.

  8. Multivariate statistical process control in product quality review assessment - A case study.

    Science.gov (United States)

    Kharbach, M; Cherrah, Y; Vander Heyden, Y; Bouklouze, A

    2017-11-01

    According to the Food and Drug Administration and the European Good Manufacturing Practices (GMP) guidelines, Annual Product Review (APR) is a mandatory requirement in GMP. It consists of evaluating a large collection of qualitative or quantitative data in order to verify the consistency of an existing process. According to the Code of Federal Regulation Part 11 (21 CFR 211.180), all finished products should be reviewed annually for the quality standards to determine the need of any change in specification or manufacturing of drug products. Conventional Statistical Process Control (SPC) evaluates the pharmaceutical production process by examining only the effect of a single factor at the time using a Shewhart's chart. It neglects to take into account the interaction between the variables. In order to overcome this issue, Multivariate Statistical Process Control (MSPC) can be used. Our case study concerns an APR assessment, where 164 historical batches containing six active ingredients, manufactured in Morocco, were collected during one year. Each batch has been checked by assaying the six active ingredients by High Performance Liquid Chromatography according to European Pharmacopoeia monographs. The data matrix was evaluated both by SPC and MSPC. The SPC indicated that all batches are under control, while the MSPC, based on Principal Component Analysis (PCA), for the data being either autoscaled or robust scaled, showed four and seven batches, respectively, out of the Hotelling T 2 95% ellipse. Also, an improvement of the capability of the process is observed without the most extreme batches. The MSPC can be used for monitoring subtle changes in the manufacturing process during an APR assessment. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

  9. Actual performance of mechanical ventilators in ICU: a multicentric quality control study.

    Science.gov (United States)

    Govoni, Leonardo; Dellaca', Raffaele L; Peñuelas, Oscar; Bellani, Giacomo; Artigas, Antonio; Ferrer, Miquel; Navajas, Daniel; Pedotti, Antonio; Farré, Ramon

    2012-01-01

    Even if the performance of a given ventilator has been evaluated in the laboratory under very well controlled conditions, inappropriate maintenance and lack of long-term stability and accuracy of the ventilator sensors may lead to ventilation errors in actual clinical practice. The aim of this study was to evaluate the actual performances of ventilators during clinical routines. A resistance (7.69 cmH(2)O/L/s) - elastance (100 mL/cmH(2)O) test lung equipped with pressure, flow, and oxygen concentration sensors was connected to the Y-piece of all the mechanical ventilators available for patients in four intensive care units (ICUs; n = 66). Ventilators were set to volume-controlled ventilation with tidal volume = 600 mL, respiratory rate = 20 breaths/minute, positive end-expiratory pressure (PEEP) = 8 cmH(2)O, and oxygen fraction = 0.5. The signals from the sensors were recorded to compute the ventilation parameters. The average ± standard deviation and range (min-max) of the ventilatory parameters were the following: inspired tidal volume = 607 ± 36 (530-723) mL, expired tidal volume = 608 ± 36 (530-728) mL, peak pressure = 20.8 ± 2.3 (17.2-25.9) cmH(2)O, respiratory rate = 20.09 ± 0.35 (19.5-21.6) breaths/minute, PEEP = 8.43 ± 0.57 (7.26-10.8) cmH(2)O, oxygen fraction = 0.49 ± 0.014 (0.41-0.53). The more error-prone parameters were the ones related to the measure of flow. In several cases, the actual delivered mechanical ventilation was considerably different from the set one, suggesting the need for improving quality control procedures for these machines.

  10. Quality control in nuclear medicine

    International Nuclear Information System (INIS)

    Leme, P.R.

    1983-01-01

    The following topics are discussed: objectives of the quality control in nuclear medicine; the necessity of the quality control in nuclear medicine; guidelines and recommendations. An appendix is given concerning the guidelines for the quality control and instrumentation in nuclear medicine. (M.A.) [pt

  11. Quality assurance, quality control and quality audit in diagnostic radiology

    International Nuclear Information System (INIS)

    Vassileva, J.

    2009-01-01

    Full text:The lecture aims to present contemporary view of quality assurance in X-Ray diagnosis and its practical realization in Bulgaria. In the lecture the concepts of quality assurance, quality control and clinical audit will be defined and their scope will be considered. An answer of the following questions will be given: why is it necessary to determine the dose of patient in X-ray studies, what is the reference dose level and how it is used for dosimetric quantity which characterized the patient's exposure in X-ray, mammography and CT scans and how they are measured, who conducted the measurement and how to keep the records, what are the variations of doses in identical tests and what defines them? The findings from a national survey of doses in diagnostic radiology, conducted in 2008-2009 and the developed new national reference levels will be presented. The main findings of the first tests of radiological equipment and the future role of quality control as well as the concept of conducting clinical audit and its role in quality assurance are also presented. Quality assurance of the diagnostic process with minimal exposure of patients is a strategic goal whose realization requires understanding, organization and practical action, both nationally and in every hospital. To achieve this the important role of education and training of physicians, radiological technicians and medical physicists is enhanced

  12. Modeling Canadian Quality Control Test Program for Steroid Hormone Receptors in Breast Cancer: Diagnostic Accuracy Study.

    Science.gov (United States)

    Pérez, Teresa; Makrestsov, Nikita; Garatt, John; Torlakovic, Emina; Gilks, C Blake; Mallett, Susan

    The Canadian Immunohistochemistry Quality Control program monitors clinical laboratory performance for estrogen receptor and progesterone receptor tests used in breast cancer treatment management in Canada. Current methods assess sensitivity and specificity at each time point, compared with a reference standard. We investigate alternative performance analysis methods to enhance the quality assessment. We used 3 methods of analysis: meta-analysis of sensitivity and specificity of each laboratory across all time points; sensitivity and specificity at each time point for each laboratory; and fitting models for repeated measurements to examine differences between laboratories adjusted by test and time point. Results show 88 laboratories participated in quality control at up to 13 time points using typically 37 to 54 histology samples. In meta-analysis across all time points no laboratories have sensitivity or specificity below 80%. Current methods, presenting sensitivity and specificity separately for each run, result in wide 95% confidence intervals, typically spanning 15% to 30%. Models of a single diagnostic outcome demonstrated that 82% to 100% of laboratories had no difference to reference standard for estrogen receptor and 75% to 100% for progesterone receptor, with the exception of 1 progesterone receptor run. Laboratories with significant differences to reference standard identified with Generalized Estimating Equation modeling also have reduced performance by meta-analysis across all time points. The Canadian Immunohistochemistry Quality Control program has a good design, and with this modeling approach has sufficient precision to measure performance at each time point and allow laboratories with a significantly lower performance to be targeted for advice.

  13. The study of the precision and accuracy of quality control in DXA bone mineral densitometry

    International Nuclear Information System (INIS)

    Gong Jian; Xu Hao

    2005-01-01

    Objective: To study the precision and accuracy of quality control (QC) in dual-energy X-ray absorptiometry (DXA) bone mineral densitometry so as to raise the reliability and necessity of the results. Methods: 1) Short-term precision trial: 30 people and 30 SD male rats were chosen, and a precision trail was performed. Each people was scanned twice and reposited in next study. The precision and the least significant change (LSC) of each examinated region were calculated. The short-term precision trail of the rats was performed in the similar way. 2) Accuracy trial: measured the body phantom supplied by factor daily, and compared the results with real value, then calculated the accuracy and correction factor. A Shewhart chart was set up based on average values. Results: 1) People's coefficient of variation (CV) and LSC in the lumbar and proximal femur were 0.7%-2.2% and 0.018-0.048 g/cm 2 . Rats' whole body short-term precision was 0.9%. 2) The average accuracy of DXA densitometer was -0.81%, the correction factor was 0.992. The average bone mineral density measured in successive 25 d was 1.244 g/cm 2 , the standard deviation (SD) was 0.008. Conclusion: The precision and accuracy trail can help to get the information about the working state of the instrument and to analyze the measured results, and can effectively raise the reliability of the measure. (authors)

  14. Printing quality control automation

    Science.gov (United States)

    Trapeznikova, O. V.

    2018-04-01

    One of the most important problems in the concept of standardizing the process of offset printing is the control the quality rating of printing and its automation. To solve the problem, a software has been developed taking into account the specifics of printing system components and the behavior in printing process. In order to characterize the distribution of ink layer on the printed substrate the so-called deviation of the ink layer thickness on the sheet from nominal surface is suggested. The geometric data construction the surface projections of the color gamut bodies allows to visualize the color reproduction gamut of printing systems in brightness ranges and specific color sectors, that provides a qualitative comparison of the system by the reproduction of individual colors in a varying ranges of brightness.

  15. Quality control in urinalysis.

    Science.gov (United States)

    Takubo, T; Tatsumi, N

    1999-01-01

    Quality control (QC) has been introduced in laboratories, and QC surveys in urinalysis have been performed by College of American Pathologist, by Japanese Association of Medical Technologists, by Osaka Medical Association and by manufacturers. QC survey in urinalysis for synthetic urine by the reagent strip and instrument made in same manufacturer, and by an automated urine cell analyser provided satisfactory results among laboratories. QC survey in urinalysis for synthetic urine by the reagent strips and instruments made by various manufacturers indicated differences in the determination values among manufacturers, and between manual and automated methods because the reagent strips and instruments have different characteristics, respectively. QC photo survey in urinalysis on the microscopic photos of urine sediment constituents indicated differences in the identification of cells among laboratories. From the results, it is necessary to standardize a reagent strip method, manual and automated methods, and synthetic urine.

  16. Actual performance of mechanical ventilators in ICU: a multicentric quality control study

    Directory of Open Access Journals (Sweden)

    Govoni L

    2012-12-01

    Full Text Available Leonardo Govoni,1 Raffaele L Dellaca,1 Oscar Peñuelas,2,3 Giacomo Bellani,4,5 Antonio Artigas,3,6 Miquel Ferrer,3,7 Daniel Navajas,3,8,9 Antonio Pedotti,1 Ramon Farré3,81TBM-Lab, Dipartimento di Bioingegneria, Politecnico di Milano University, Milano, Italy; 2Hospital Universitario de Getafe – CIBERES, Madrid, Spain; 3CIBER de Enfermedades Respiratorias, Bunyola, Spain; 4Department of Experimental Medicine, University of Milan, Bicocca, Italy; 5Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Monza (MI, Italy; 6Critical Care Center, Sabadell Hospital, Corporació Sanitaria Universitaria Parc Tauli, Universitat Autonoma de Barcelona, CIBERES, Spain; 7Department of Pneumology, Hospital Clinic, IDIBAPS, Barcelona, Spain; 8Unitat de Biofísica i Bioenginyeria, Facultat de Medicina, Universidad de Barcelona-IDIBAPS, Barcelona, Spain; 9Institut de Bioenginyeria de Catalunya, Barcelona, SpainAbstract: Even if the performance of a given ventilator has been evaluated in the laboratory under very well controlled conditions, inappropriate maintenance and lack of long-term stability and accuracy of the ventilator sensors may lead to ventilation errors in actual clinical practice. The aim of this study was to evaluate the actual performances of ventilators during clinical routines. A resistance (7.69 cmH2O/L/s – elastance (100 mL/cmH2O test lung equipped with pressure, flow, and oxygen concentration sensors was connected to the Y-piece of all the mechanical ventilators available for patients in four intensive care units (ICUs; n = 66. Ventilators were set to volume-controlled ventilation with tidal volume = 600 mL, respiratory rate = 20 breaths/minute, positive end-expiratory pressure (PEEP = 8 cmH2O, and oxygen fraction = 0.5. The signals from the sensors were recorded to compute the ventilation parameters. The average ± standard deviation and range (min–max of the ventilatory parameters were the following: inspired

  17. A hard day's night: a longitudinal study on the relationships among job demands and job control, sleep quality and fatigue.

    Science.gov (United States)

    de Lange, Annet H; Kompier, Michiel A J; Taris, Toon W; Geurts, Sabine A E; Beckers, Debby G J; Houtman, Irene L D; Bongers, Paulien M

    2009-09-01

    This prospective four-wave study examined (i) the causal direction of the longitudinal relations among job demands, job control, sleep quality and fatigue; and (ii) the effects of stability and change in demand-control history on the development of sleep quality and fatigue. Based on results of a four-wave complete panel study among 1163 Dutch employees, we found significant effects of job demands and job control on sleep quality and fatigue across a 1-year time lag, supporting the strain hypothesis (Demand-Control model; Karasek and Theorell, Basic Books, New York, 1990). No reversed or reciprocal causal patterns were detected. Furthermore, our results revealed that cumulative exposure to a high-strain work environment (characterized by high job demands and low job control) was associated with elevated levels of sleep-related complaints. Cumulative exposure to a low-strain work environment (i.e. low job demands and high job control) was associated with the highest sleep quality and lowest level of fatigue. Our results revealed further that changes in exposure history were related to changes in reported sleep quality and fatigue across time. As expected, a transition from a non-high-strain towards a high-strain job was associated with a significant increase in sleep-related complaints; conversely, a transition towards a non-high-strain job was not related to an improvement in sleep-related problems.

  18. Pharmacobotanical study of the leaf and stem of Mikania lanuginosa for its quality control

    Directory of Open Access Journals (Sweden)

    Mariana Amorin

    Full Text Available Mikania lanuginosa DC, Asteraceae, is popularly known as "cipó-cabeludo" in Brazil due to a remarkable number of trichomes on its leaves and stems. It shows antimicrobial activity against Staphylococcus aureus, S. epidermidis and Bacillus cereus. This species can be confused with M. microlepis Baker and M. hirsutissima DC for substitution and tampering purposes. The aim of this study was to investigate the morpho-anatomy of leaf and stem of M. lanuginosa to obtain pharmacobotanical data that may contribute to its identification and taxonomic definition from other species of Mikania. The leaves and stems were investigated using scanning electron microscopy and light microscopy techniques. Mikania lanuginosa shows a uniseriate epidermis covered by a thin and smooth cuticle. The epidermal cells present sinuous anticlinal walls on both sides and anomocytic stomata were observed. A few glandular trichomes and numerous non-glandular trichomes were identified on both surfaces. The mesophyll is dorsiventral, the midrib has a biconvex contour and the petiole shows a circular shape in a cross-section. The stem has a circular shape. These pharmacobotanical features described for M. lanuginosa support data for its identification and taxonomic delimitation from other Mikania species, and are a contribution for the quality control of herbal drugs.

  19. Impact of wearing fixed orthodontic appliances on quality of life among adolescents: Case-control study.

    Science.gov (United States)

    Costa, Andréa A; Serra-Negra, Júnia M; Bendo, Cristiane B; Pordeus, Isabela A; Paiva, Saul M

    2016-01-01

    To investigate the impact of wearing a fixed orthodontic appliance on oral health-related quality of life (OHRQoL) among adolescents. A case-control study (1 ∶ 2) was carried out with a population-based randomized sample of 327 adolescents aged 11 to 14 years enrolled at public and private schools in the City of Brumadinho, southeast of Brazil. The case group (n  =  109) was made up of adolescents with a high negative impact on OHRQoL, and the control group (n  =  218) was made up of adolescents with a low negative impact. The outcome variable was the impact on OHRQoL measured by the Brazilian version of the Child Perceptions Questionnaire (CPQ 11-14) - Impact Short Form (ISF:16). The main independent variable was wearing fixed orthodontic appliances. Malocclusion and the type of school were identified as possible confounding variables. Bivariate and multiple conditional logistic regressions were employed in the statistical analysis. A multiple conditional logistic regression model demonstrated that adolescents wearing fixed orthodontic appliances had a 4.88-fold greater chance of presenting high negative impact on OHRQoL (95% CI: 2.93-8.13; P appliances. A bivariate conditional logistic regression demonstrated that malocclusion was significantly associated with OHRQoL (P  =  .017), whereas no statistically significant association was found between the type of school and OHRQoL (P  =  .108). Adolescents who wore fixed orthodontic appliances had a greater chance of reporting a negative impact on OHRQoL than those who did not wear such appliances.

  20. Quality of life psychosocial characteristics in Greek patients with leg ulcers: a case control study.

    Science.gov (United States)

    Kouris, Anargyros; Armyra, Kalliopi; Christodoulou, Christos; Sgontzou, Themis; Karypidis, Dimitrios; Kontochristopoulos, George; Liordou, Fotini; Zakopoulou, Nikoletta; Zouridaki, Eftychia

    2016-10-01

    Chronic leg ulcers are a public health problem that can have a significant impact on the patient's physical, socioeconomic and psychological status. The aim of this study is to evaluate the quality of life, anxiety and depression, self-esteem and loneliness in patients suffering from leg ulcers. A total of 102 patients were enrolled in the study. The quality of life, anxiety and depression, self-esteem and loneliness of the patient were assessed using the Dermatology Life Quality Index (DLQI), Hospital Anxiety and Depression Scale (HADS), Rosenberg's Self-esteem Scale (RSES) and the UCLA Loneliness Scale (UCLA-Version 3), respectively. The mean DLQI score was 13·38 ± 2·59, suggesting a serious effect on the quality of life of patients. Those with leg ulcers had statistically significant higher scores according to the HADS-total scale (P = 0·031) and HADS-anxiety subscale (P = 0·015) compared with healthy volunteers. Moreover, a statistically significant difference was found between the two groups concerning the UCLA-scale (P = 0·029). Female patients presented with a higher score of anxiety (P = 0·027) and social isolation (P = 0·048), and worse quality of life (P = 0·018) than male patients. A severe quality of life impairment was documented, reflecting a significant psychosocial impact on patients with leg ulcers. © 2014 The Authors. International Wound Journal © 2014 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

  1. Chemical quality of tap water in Madrid: multicase control cancer study in Spain (MCC-Spain).

    Science.gov (United States)

    Fernández-Navarro, Pablo; Villanueva, Cristina M; García-Pérez, Javier; Boldo, Elena; Goñi-Irigoyen, Fernando; Ulibarrena, Enrique; Rantakokko, Panu; García-Esquinas, Esther; Pérez-Gómez, Beatriz; Pollán, Marina; Aragonés, Nuria

    2017-02-01

    Chronic consumption of water, which contains contaminants, may give rise to adverse health effects. The Madrid region, covered by the population-based multicase-control (MCC-Spain) study, includes two drinking water supply areas. The different sources of the water, coupled together with the possible differences in water management, mean that there may be differences in drinking water quality. In the context of the MCC study, our aims were to describe contaminant concentrations in tap water drawn from various sampling points distributed around the region, assess these concentrations by reference to guideline values and study possible differences between the two supply areas. Tap water samples were collected from 34 sampling points in 7 towns in the Madrid region (19-29 April 2010), and 23 contaminants (metals, nitrates, disinfection by-product and Mutagen X levels) were quantified. We undertook a descriptive analysis of the contaminant concentrations in the water and compared them between the two water supply areas (Wilcoxon test). We created maps representing the distribution of the concentrations observed at water sampling points and assessed the correlations (Spearman's coefficient) between the different parameters measured. The concentrations of the contaminants were below guideline values. There were differences between the two supply areas in concentration of nitrates (p value = 0.0051) and certain disinfection by-products. While there were positive correlations (rho >0.70) among some disinfection by-products, no correlations were found in metals or nitrates. The differences in nitrate levels could be linked to differences in farming/industrial activities in the catchment areas and in disinfection by-products might be related to the existence of different treatment systems or bromine content in source waters.

  2. Results of quality control studies of technetium 99m labelled radiopharmaceuticals prepared from kits (1978-79)

    International Nuclear Information System (INIS)

    McLean, J.R.; Rockwell, L.J.; Welsh, W.J.

    1982-01-01

    This report summarizes the results of quality control studies of Tc 99m-labelled normal albumin, macroaggregated albumin, and bone imaging radiopharmaceuticals prepared from commercially available kits. It includes all analyses performed from January 1978 to December 1979. The results presented were obtained through the application of various in vitro and animal (mouse) biodistribution studies

  3. A Study on the Quality Control of 18F-FDG Radiopharmaceutical

    International Nuclear Information System (INIS)

    Kim, Ssang Tae; Yong, Chul Soon; Han, Eun Ok

    2010-01-01

    The types of test items which were recorded in this test report of quality control domestic 18 F-FDG radiopharmaceutical which consisted of 13 different types: appearance, half-life, radioactive heterokaryosis, radiochemical Confirmation (measure of Rf value), radiochemical Purity, Ethanol, Acetonitrile, Kryptofix, Aluminium, pH, Endotoxin, aseptic test, and radioactivity·ml-1. The record was fully recorded in 'appearance', 'radioactive heterokaryosis', 'pH', 'Endotoxin', and 'aseptic test'. In 'half-life', 'radiochemical Confirmation (measure of Rf value), 'radiochemical Purity', 'Ethanol', 'Acetonitrile', 'Kryptofix', 'Aluminium', 'radioactivity·ml-1', there were differences in records of each manufacturing business on radioactive medicine and medical supplies. The result of the test showed all 13 items of quality control test were 100% suitable on the basis of recorded data. There were more radiopharmaceutical made in the laboratory than in hospitals and businesses and in for result of suitability test, the laboratory showed higher suitability than did the hospitals or businesses. Domestically, there are differences of the test report items in the safety of radiopharmaceutical of each facility, and since it is not standardized, supplements are needed. To submit standardized test reports of quality guarantee in radiopharmaceutical, GMP of U.S. and CE Mark of Europe should be referred as well as receiving advice from professionals to standardize as suitable domestic standard

  4. Study on the internal quality control of TGAb and TMAb RIA in clinical laboratory

    International Nuclear Information System (INIS)

    Huang Jianrong

    2005-01-01

    To investigate the possible causes of the occasional instability of thyroglobulin anti- body(TGAb) and thyroid microsome antibody (TMAb) detection in the laboratory, the control serums of low, middle, and high value of different batches were measured and the stability of the labeled antigens stored at 2-8 degree C and below zero was observed. The results showed that the maximal variances of high value control serums for TGAb and TMAb between different batches were 33.0% and 32.5%, respectively. This was caused by the changes of titer of second anti- bodies. The labeled antigens stored below zero showed better stability. The strict internal quality control is an efficient measure to improve the measurement precision. (authors)

  5. quality control of the radiopharmaceuticals

    International Nuclear Information System (INIS)

    Boukarra, Hajer; Boubakri, Rania

    2006-01-01

    This work is a contribution to the quality control of two radio pharmaceutical. Our study was carried out on the rat. These results enable us to draw the following conclusions: - the control of the purity of the cerebral tracers (Cytectrenes) is carried out by HPLC by using a detector of radioactivity which offers a great sensitivity. - the radiochemical output of marking of Kit MDP determined by thin chromatography of layer is 99%. - The study of the biodistribution in the rat showed an affinity raised for the feet bone. - These results are in conformity with the European pharmacopoeia, which enables us to require a marketing authorization. (author)

  6. Regulating Animal Health, Gender and Quality Control: A Study of Veterinary Surgeons in Great Britain

    Science.gov (United States)

    Enticott, Gareth

    2012-01-01

    This paper explores the validity of performance management regimes for quality assuring animal health regulation by comparing the results of tests for bovine tuberculosis (bTB) between male and female vets. In doing so it hopes to present some practical solutions to the regulation of animal disease and encourage further sociological study of the…

  7. Commercial jet fuel quality control

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, K.H.

    1995-05-01

    The paper discusses the purpose of jet fuel quality control between the refinery and the aircraft. It describes fixed equipment, including various types of filters, and the usefulness and limitations of this equipment. Test equipment is reviewed as are various surveillance procedures. These include the Air Transport Association specification ATA 103, the FAA Advisory Circular 150/5230-4, the International Air Transport Association Guidance Material for Fuel Quality Control and Fuelling Service and the Guidelines for Quality Control at Jointly Operated Fuel Systems. Some past and current quality control problems are briefly mentioned.

  8. Double disadvantage: a case control study on health-related quality of life in children with sickle cell disease

    NARCIS (Netherlands)

    Hijmans, Channa T.; Fijnvandraat, Karin; Oosterlaan, Jaap; Heijboer, Harriët; Peters, Marjolein; Grootenhuis, Martha A.

    2010-01-01

    Low health-related quality of life (HRQoL) of children with sickle cell disease (SCD) may be associated with consequences of the disease, or with the low socio-economic status (SES) of this patient population. The aim of this study was to investigate the HRQoL of children with SCD, controlling for

  9. A Study on the Quality Control of {sup 18}F-FDG Radiopharmaceutical

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ssang Tae [CareCamp Inc., Seoul (Korea, Republic of); Yong, Chul Soon [Yeungnam University, Gyeongsan (Korea, Republic of); Han, Eun Ok [Daegu Health College, Daegu (Korea, Republic of)

    2010-12-15

    The types of test items which were recorded in this test report of quality control domestic {sup 18}F-FDG radiopharmaceutical which consisted of 13 different types: appearance, half-life, radioactive heterokaryosis, radiochemical Confirmation (measure of Rf value), radiochemical Purity, Ethanol, Acetonitrile, Kryptofix, Aluminium, pH, Endotoxin, aseptic test, and radioactivity·ml-1. The record was fully recorded in 'appearance', 'radioactive heterokaryosis', 'pH', 'Endotoxin', and 'aseptic test'. In 'half-life', 'radiochemical Confirmation (measure of Rf value), 'radiochemical Purity', 'Ethanol', 'Acetonitrile', 'Kryptofix', 'Aluminium', 'radioactivity·ml-1', there were differences in records of each manufacturing business on radioactive medicine and medical supplies. The result of the test showed all 13 items of quality control test were 100% suitable on the basis of recorded data. There were more radiopharmaceutical made in the laboratory than in hospitals and businesses and in for result of suitability test, the laboratory showed higher suitability than did the hospitals or businesses. Domestically, there are differences of the test report items in the safety of radiopharmaceutical of each facility, and since it is not standardized, supplements are needed. To submit standardized test reports of quality guarantee in radiopharmaceutical, GMP of U.S. and CE Mark of Europe should be referred as well as receiving advice from professionals to standardize as suitable domestic standard.

  10. Gynecomastia Surgery-Impact on Life Quality: A Prospective Case-Control Study.

    Science.gov (United States)

    Kasielska-Trojan, Anna; Antoszewski, Bogusław

    2017-03-01

    To evaluate the results of surgical treatment of gynecomastia in the context of quality of life and satisfaction after the surgery. Fifty male patients (mean age, 25.1 years [SD = 8 years]) who underwent surgery for gynecomastia and completed both (preoperative and postoperative) stages of the study were included in the analysis. The quality-of-life evaluation instrument was The Short Form-36 Health Survey Questionnaire. Additionally, we used a short questionnaire including 2 questions about patient satisfaction with gynecomastia surgery. The overall change in life satisfaction after gynecomastia surgery was 1 point on Likert scale (sign test, P gynecomastia surgery scored significantly higher than before the procedure in all Short Form-36 Health Survey Questionnaire domains as well as in 2 main scales Psychical and Physical Health. The changes were especially visible for the domain social functioning and a scale Psychical Health (P Gynecomastia surgery significantly improved men's life quality in all aspects and especially in the social aspect and psychical health. This indicates that adult men with gynecomastia are a specific group of patients, in which surgery may result in life quality improvement even over the average scores.

  11. Control of quality in mammography

    International Nuclear Information System (INIS)

    2006-10-01

    The present protocol of quality control/quality assurance in mammography is the result of the work of two regional projects realised in Latin America within the frame of ARCAL with the support of the IAEA. The first is ARCAL LV (RLA/6/043) project on quality assurance/quality control in mammography studies which analysed the present situation of the mammography in the member countries of the project which include: Bolivia, Colombia, Costa Rica, Cuba, El Salvador, Guatemala, Nicaragua, Panama, Paraguay, Peru, Dominican Republic and Republic of Venezuela and the second is ARCAL XLIX (RLA/9/035) project, whose members were Brazil, Colombia, Cuba, Chile, Mexico, and Peru, worked the application of Basic Safety Standards for the protection against ionising radiation with the aim to improve radiation protection in X-ray diagnosis medical practices through the implementation of the Basic Safety Standards (BSS) related to x-ray diagnosis in selected hospitals located in each country involved in the project. The work of both projects had been consolidated and harmonized in the present publication

  12. Perioperative Care and the Importance of Continuous Quality Improvement—A Controlled Intervention Study in Three Tanzanian Hospitals

    Science.gov (United States)

    Mtatifikolo, Ferdinand; Ngoli, Baltazar; Neuner, Bruno; Wernecke, Klaus–Dieter; Spies, Claudia

    2015-01-01

    Introduction Surgical services are increasingly seen to reduce death and disability in Sub-Saharan Africa, where hospital-based mortality remains alarmingly high. This study explores two implementation approaches to improve the quality of perioperative care in a Tanzanian hospital. Effects were compared to a control group of two other hospitals in the region without intervention. Methods All hospitals conducted quality assessments with a Hospital Performance Assessment Tool. Changes in immediate outcome indicators after one and two years were compared to final outcome indicators such as Anaesthetic Complication Rate and Surgical Case Fatality Rate. Results Immediate outcome indicators for Preoperative Care in the intervention hospital improved (52.5% in 2009; 84.2% in 2011, pimproved to then decline again (63.3% in 2009; 70% in 2010; 58.6% in 2011). In the control group, preoperative care declined from 50.8% (2009) to 32.8% (2011, p improved, while at the same time final outcome declined (Surgical Case Fatality, Anaesthetic Complication Rate). Compared to the control group, final outcome improved more in the intervention hospital, although the effect was not significant over the whole study period. Documentation of final outcome indicators seemed inconsistent. Immediate outcome indicators seem more helpful to steer the Continuous Quality Improvement program. Conclusion Specific interventions as part of Continuous Quality Improvement might lead to sustainable improvement of the quality of care, if embedded in a multi-faceted approach. PMID:26327392

  13. Pharmacognostic study and development of quality control parameters for fruit, bark and leaf of Zanthoxylum armatum (Rutaceae

    Directory of Open Access Journals (Sweden)

    Fiaz Alam

    2015-01-01

    Conclusion: The data generated from this study would be of help in the authentication of various parts of Z. armatum, an important constituent of various herbal drug formulations. The qualitative and quantitative microscopic features would prove useful for laying down pharmacopoeial standards. Morphology as well as various pharmacognostic aspects of different parts of the plant were studied and have been described here along with phytochemical, physicochemical studies, which will help in authentication and quality control.

  14. Quality control and data-handling in multicentre studies: the case of the Multicentre Project for Tuberculosis Research

    Directory of Open Access Journals (Sweden)

    Caloto Teresa

    2001-12-01

    Full Text Available Abstract Background The Multicentre Project for Tuberculosis Research (MPTR was a clinical-epidemiological study on tuberculosis carried out in Spain from 1996 to 1998. In total, 96 centres scattered all over the country participated in the project, 19935 "possible cases" of tuberculosis were examined and 10053 finally included. Data-handling and quality control procedures implemented in the MPTR are described. Methods The study was divided in three phases: 1 preliminary phase, 2 field work 3 final phase. Quality control procedures during the three phases are described. Results: Preliminary phase: a organisation of the research team; b design of epidemiological tools; training of researchers. Field work: a data collection; b data computerisation; c data transmission; d data cleaning; e quality control audits; f confidentiality. Final phase: a final data cleaning; b final analysis. Conclusion The undertaking of a multicentre project implies the need to work with a heterogeneous research team and yet at the same time attain a common goal by following a homogeneous methodology. This demands an additional effort on quality control.

  15. Work stress, asthma control and asthma-specific quality of life: Initial evidence from a cross-sectional study.

    Science.gov (United States)

    Hartmann, Bettina; Leucht, Verena; Loerbroks, Adrian

    2017-03-01

    Research has suggested that psychological stress is positively associated with asthma morbidity. One major source of stress in adulthood is one's occupation. However, to date, potential links of work stress with asthma control or asthma-specific quality of life have not been examined. We aimed to address this knowledge gap. In 2014/2015, we conducted a cross-sectional study among adults with asthma in Germany (n = 362). For the current analyses that sample was restricted to participants in employment and reporting to have never been diagnosed with chronic obstructive pulmonary disease (n = 94). Work stress was operationalized by the 16-item effort-reward-imbalance (ERI) questionnaire, which measures the subcomponents "effort", "reward" and "overcommitment." Participants further completed the Asthma Control Test and the Asthma Quality of Life Questionnaire-Sydney. Multivariable associations were quantified by linear regression and logistic regression. Effort, reward and their ratio (i.e. ERI ratio) did not show meaningful associations with asthma morbidity. By contrast, increasing levels of overcommitment were associated with poorer asthma control and worse quality of life in both linear regression (ß = -0.26, p = 0.01 and ß = 0.44, p work-related overcommitment with asthma control and asthma-specific quality of life. Longitudinal studies with larger samples are needed to confirm our findings and to disentangle the potential causality of associations.

  16. INFORMATION SYSTEM QUALITY CONTROL KNOWLEDGE

    Directory of Open Access Journals (Sweden)

    Vladimir Nikolaevich Babeshko

    2017-02-01

    Full Text Available The development of the educational system is associated with the need to control the quality of educational services. Quality control knowledge is an important part of the scientific process. The penetration of computers into all areas of activities changing approaches and technologies that previously they were used.

  17. Studies of quality control of 99mTc-labelled macroaggregated albumin: Pt. 1

    International Nuclear Information System (INIS)

    Fukuoka, Masamichi; Kobayashi, Tetsu; Tanaka, Akira; Satoh, Takemichi; Kubodera, Akiko

    1993-01-01

    The aggregative condition of albumin was investigated using bovine serum albumin (BSA) as a model for quality control of 99m Tc-macroaggregated albumin ( 99 Tc-MAA). Uniformalized aggregates were obtained from the oxidized non-mercapt-type of BSA by heating. The size of the aggregates was affected by the pH and the types of buffer solutions used as well as the concentrations of albumin and buffers. The β form structure of the albumin was more stable on heating and this may contribute to its aggregation. Aggregation of oxidized non-mercaptalbumin afforded a portion of smaller sized particles in MAA, this being an inappropriate factor for scintiscanning of lungs. Our results suggest that it is necessary to remove oxidized type albumin from human serum albumin as the starting material, in order to prepare MAA with a uniform and larger particle size. (Author)

  18. Slim edge studies, design and quality control of planar ATLAS IBL pixel sensors

    Energy Technology Data Exchange (ETDEWEB)

    Wittig, Tobias

    2013-05-08

    One of the four large experiments at the LHC at CERN is the ATLAS detector, a multi purpose detector. Its pixel detector, composed of three layers, is the innermost part of the tracker. As it is closest to the interaction point, it represents a basic part of the track reconstruction. Besides the requested high resolution one main requirement is the radiation hardness. In the coming years the radiation damage will cause deteriorations of the detector performance. With the planned increase of the luminosity, especially after the upgrade to the High Luminosity LHC, this radiation damage will be even intensified. This circumstance necessitates a new pixel detector featuring improved radiation hard sensors and read-out chips. The present shutdown of the LHC is already utilized to insert an additional b-layer (IBL) into the existing ATLAS pixel detector. The current n-in-n pixel sensor design had to be adapted to the new read-out chip and the module specifications. The new stave geometry requests a reduction of the inactive sensor edge. In a prototype wafer production all modifications have been implemented. The sensor quality control was supervised which led to the decision of the final sensor thickness. In order to evaluate the performance of the sensor chip assemblies with an innovative slim edge design, they have been operated in test beam setups before and after irradiation. Furthermore, the quality control of the planar IBL sensor wafer production was supervised from the stage of wafer delivery to that before the flip chip process to ensure a sufficient amount of functional sensors for the module production.

  19. Frontiers in statistical quality control

    CERN Document Server

    Wilrich, Peter-Theodor

    2004-01-01

    This volume treats the four main categories of Statistical Quality Control: General SQC Methodology, On-line Control including Sampling Inspection and Statistical Process Control, Off-line Control with Data Analysis and Experimental Design, and, fields related to Reliability. Experts with international reputation present their newest contributions.

  20. Development study of a quality control for clinical dosimeters of radiotherapy

    International Nuclear Information System (INIS)

    Damatto, Willian B.; Potiens, Maria P.A.; Santos, Gelson P.; Vivolo, Vitor

    2011-01-01

    This paper presents the partial results of a scientific initiation which the main objective is the enhancement of the quality system of the dosimeter calibration laboratory (LCI-IPEN) on 60 Co gamma radiation to the International Atomic Energy Agency (IAEA), being this the new protocol denominated Calibration of Reference Dosimeters for External Beam Radiotherapy (Technical Reports Series 469). This paper is an actualization of the protocol Absorbed Dose Determination for External Beam Radiotherapy (Technical Reports Series 398). Therefore, in this paper it will presented the study on the clinical dosimeters composed of electrometer, wires, triaxial connectors, and thimble type ionization chamber - 0.60 cm 3 . (author)

  1. Immediate outcome indicators in perioperative care: a controlled intervention study on quality improvement in hospitals in Tanzania.

    Science.gov (United States)

    Bosse, Goetz; Mtatifikolo, Ferdinand; Abels, Wiltrud; Strosing, Christian; Breuer, Jan-Philipp; Spies, Claudia

    2013-01-01

    Outcome assessment is the standard for evaluating the quality of health services worldwide. In this study, outcome has been divided into immediate and final outcome. Aim was to compare an intervention hospital with a Continuous Quality Improvement approach to a control group using benchmark assessments of immediate outcome indicators in surgical care. Results were compared to final outcome indicators. Surgical care quality in six hospitals in Tanzania was assessed from 2006-2011, using the Hospital Performance Assessment Tool. Independent observers assessed structural, process and outcome quality using checklists based on evidence-based guidelines. The number of surgical key procedures over the benchmark of 80% was compared between the intervention hospital and the control group. Results were compared to Case Fatality Rates. In the intervention hospital, in 2006, two of nine key procedures reached the benchmark, one in 2009, and four in 2011. In the control group, one of nine key procedures reached the benchmark in 2006, one in 2009, and none in 2011. Case Fatality Rate for all in-patients in the intervention hospital was 5.5% (n = 12,530) in 2006, 3.5% (n = 21,114) in 2009 and 4.6% (n = 18,840) in 2011. In the control group it was 3.1% (n = 17,827) in 2006, 4.2% (n = 13,632) in 2009 and 3.8% (n = 17,059) in 2011. Results demonstrated that quality assurance improved performance levels in both groups. After the introduction of Continuous Quality Improvement, performance levels improved further in the intervention hospital while quality in the district hospital did not. Immediate outcome indicators appeared to be a better steering tool for quality improvement compared to final outcome indicators. Immediate outcome indicators revealed a need for improvement in pre- and postoperative care. Quality assurance programs based on immediate outcome indicators can be effective if embedded in Continuous Quality Improvement. Nevertheless, final outcome

  2. [Application study of human sperm motility bioassay in IVF laboratory quality control].

    Science.gov (United States)

    Cai, Xia; Pomeroy, Kimball O; Mattox, John H

    2006-07-01

    To investigate the sensitivity of human sperm survival bioassay to using known concentrations of potential toxin of formalin and to elevate the application value of human sperm motility assay as a quality control method in detecting the components used in IVF program. Fresh semen was obtained from healthy males at andrology laboratory by masturbation. Sperm was processed on a gradient column of isolate medium and PBS medium. In experiment 1, the medium with 0.25%, 0.75% concentration of formalin and control medium were added to the Falcon culture tubes containing HTF medium with or without 0.3% bovine albumin serum and with or without light mineral oil. In experiment 2, in 3 types of culture tubes containing HTF medium with or without 0.3% bovine albumin serum and with or without light mineral oil, the sperm was exposed to each culture tube and cultured for 24 and 48 hrs at room temperature, and the motile sperms were counted under the microscope. The average sperm motility index in the HTF medium with 0.25% formalin at 24 hrs was 0.594 +/- 0.331, significantly higher than in the HTF medium with 0.75% formalin (0.450 +/- 0.284) (P average sperm survival indexes were 0.683 +/- 0.334 and 0.527 +/- 0.345, respectively, higher than without bovine albumin serum and light mineral oil (0.394 +/- 0.311 and 0.424 +/- 0.311). The average sperm index of 7 ml tissue culture tube made in Denmark was 0.677 +/- 0.335, higher than the other two types of culture tubes made in the USA (0.551 +/- 0.317 and 0.596 +/- 0.327) (P sperm cultured in the medium with 0.3% bovine albumin serum and light mineral oil, the average sperm survival indexes were 0.821 +/- 0.259 and 0.645 +/- 0.335, respectively, higher than without bovine albumin serum or light mineral oil (0.571 +/- 0.321 and 0.395 +/- 0.245) (P sperm survival bioassay is a sensitivity quality control method to detect the components in the IVF laboratory. The 7 ml tissue culture tube made in Denmark is most suitable for culturing

  3. Water quality-based real time control of integrated urban drainage: a preliminary study from Copenhagen, Denmark

    DEFF Research Database (Denmark)

    Vezzaro, Luca; Lund Christensen, Margit; Thirsing, Carsten

    2013-01-01

    Global Real Time Control (RTC) of urban drainage systems is increasingly seen as cost-effective solution for responding to increasing performance demands. This study investigated the potential for including water-quality based RTC into the global control strategy which is under implementation...... in the Lynetten catchment (Copenhagen, Denmark). Two different strategies were simulated, considering: (i) water quality at the wastewater treatment plant (WWTP) inlet and (ii) pollution discharge to the bathing areas. These strategies were included in the Dynamic Overflow Risk Assessment (DORA) RTC strategy......, which allows for prioritization of the discharge points in the systems according to their sensitivity. A conceptual hydrological model was used to assess the performance of the integrated control strategy over an entire year. The simulation results showed the benefits of the proposed approaches...

  4. IMPACT OF PSYCHOPATHOLOGY OF ADULT OBSESSIVE COMPULSIVE DISORDER ON QUALITY OF LIFE: A PATIENT CONTROLLED STUDY

    Directory of Open Access Journals (Sweden)

    Mohd. Aleem

    2015-12-01

    Full Text Available BACKGROUND Obsessive-compulsive disorder (OCD is the 10th leading cause of disability of all medical conditions in the industrialized world and the ‘Quality of Life’ has emerged as a valid parameter to measure the outcome of illness and effectiveness of treatment. OBJECTIVE To see the quality of life, functioning and clinical variables between the OCD patient and the ‘Patient control’ group MATERIAL AND METHODS A total of 120 probands were assessed, of which 60 subjects were OCD patients and 60 stable schizophrenia patients were used as patient control group. Yale-Brown Obsessive-Compulsive Rating Scale, Positive and Negative Symptom Scale for Schizophrenia, Hamilton Rating Scale for Depression, Hamilton Rating Scale for Anxiety, The Brown Assessment of Beliefs Scale, WHOQOL-BREF, Global Assessment of Functioning Scale were applied as per the protocol. The data was analysed using descriptive statistics with the help of SPSS version 16.0 for Windows. RESULTS The cost of medication was significantly higher in OCD group as compared to Schizophrenia Group. Depression and anxiety scores were significantly higher in OCD group. Global functioning was significantly better in schizophrenia group but quality of life better in OCD group on Physical Health domain and Environment domain of WHOQOL-BREF. CONCLUSION The Psychopathology of OCD spared satisfaction with sleep, ability to perform daily living activities, capacity to work, ability to get around, energy for everyday life, physical pain and need for any medical treatment to function in daily life, satisfaction with the conditions of your living places, access to health services, transport, opportunities for leisure activities, money to meet the needs, availability of the required information, and safety in daily life; when compared to stable schizophrenia patients The Psychopathology of OCD had as severe an impact as Schizophrenia on ‘enjoying life, finding it meaningful, level of negative

  5. Decision Maker Perception of Information Quality: A Case Study of Military Command and Control

    Science.gov (United States)

    Morgan, Grayson B.

    2013-01-01

    Decision maker perception of information quality cues from an "information system" (IS) and the process which creates such meta cueing, or data about cues, is a critical yet un-modeled component of "situation awareness" (SA). Examples of common information quality meta cueing for quality criteria include custom ring-tones for…

  6. Control options for river water quality improvement: a case study of ...

    African Journals Online (AJOL)

    Using a simple conceptual dynamic river water quality model, the effects of different basin-wide water quality management options on downstream water quality improvements in a semi-arid river, the Crocodile River (South Africa) were investigated. When a river is impacted by high rates of freshwater withdrawal (in its ...

  7. Establishment for quality control of experimental animal

    International Nuclear Information System (INIS)

    Kim, Tae Hwan; Kim, Soo Kwan; Kim, Tae Kyoung

    1999-06-01

    Until now, because we have imported experimental animal from foreign experimental animal corporation, we could have saved money by establishing the quality control of animal in barrier system. In order to improve the quality of animal experiment and efficiency of biomedical study, it is indispensable to control many factors that effect in the experiment. Therefore, it is essential to organize the system of laboratory animal care for enhancing reliability and revivability of experimental results. The purpose of the present investigation was to establish the quality control system of experimental animals that we can provide good quality animals according to the experimental condition of each investigator although the exact quality control system to estimate the infection of bacteria and virus easily remains ill-defined yet. Accordingly, we established the useful quality control system for microbiologic monitoring and environmental monitoring to protect experimental animal from harmful bacteria and virus

  8. Establishment for quality control of experimental animal

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Hwan; Kim, Soo Kwan; Kim, Tae Kyoung

    1999-06-01

    Until now, because we have imported experimental animal from foreign experimental animal corporation, we could have saved money by establishing the quality control of animal in barrier system. In order to improve the quality of animal experiment and efficiency of biomedical study, it is indispensable to control many factors that effect in the experiment. Therefore, it is essential to organize the system of laboratory animal care for enhancing reliability and revivability of experimental results. The purpose of the present investigation was to establish the quality control system of experimental animals that we can provide good quality animals according to the experimental condition of each investigator although the exact quality control system to estimate the infection of bacteria and virus easily remains ill-defined yet. Accordingly, we established the useful quality control system for microbiologic monitoring and environmental monitoring to protect experimental animal from harmful bacteria and virus.

  9. Study of continuous-wave domain fluorescence diffuse optical tomography for quality control on agricultural produce

    Energy Technology Data Exchange (ETDEWEB)

    Nadhira, Vebi, E-mail: vebi@tf.itb.ac.id; Kurniadi, Deddy, E-mail: vebi@tf.itb.ac.id; Juliastuti, E., E-mail: vebi@tf.itb.ac.id; Sutiswan, Adeline, E-mail: vebi@tf.itb.ac.id [Instrumentation and Control Research Group, Faculty of Industrial Technology, Institute Technology of Bandung, Ganesha 10 40132 Bandung (Indonesia)

    2014-03-24

    The importance of monitoring the quality of vegetables and fruits is prosperity by giving a competitive advantage for producer and providing a more healthy food for consumer. Diffuse Optical Tomography (DOT) is offering the possibility to detect the internal defects of the agricultural produce quality. Fluorescence diffuse optical tomography (FDOT) is the development of DOT, offering the possibilities to improve spatial resolution and to contrast image. The purpose of this research is to compare FDOT and DOT in forward analysis with continuous wave approach. The scattering and absorbing parameters of potatoes are used to represent the real condition. The object was illuminated by the NIR source from some positions on the boundary of object. A set of NIR detector are placed on the peripheral position of the object to measure the intensity of propagated or emitted light. In the simulation, we varied a condition of object then we analyzed the sensitivity of forward problem. The result of this study shows that FDOT has a better sensitivity than DOT and a better potential to monitor internal defects of agricultural produce because of the contrast value between optical and fluorescence properties of agricultural produce normal tissue and defects.

  10. Pilot study of the radiodiagnostic quality control in Habana (Cuba). Dosimetric results in chest and spin cords radiographs

    International Nuclear Information System (INIS)

    Saez Nunnez, D.G.; Borroto Valdes, M.; Mesa Hernandez, M.; Risco Reyma, L. del; Borras, C

    1998-01-01

    This paper presents the results of a quality control pilot study in diagnostic radiology carried out in 10 hospitals of Havana City, Cuba. The study included dosimetric determinations for two common radiographic protections: posterior-anterior chest and lateral lumbosacral spine. A total of 21 x-ray units and 12 dark rooms were evaluated. The deficiencies related to film processing, as well as other problems associated with the dark room are presented. The most significant problems related to equipment were: the lack of reproducibility and linearity of the x-ray generator and the non-coincidence of radiation and light fields. A great variability of the entrance surface dose for the same type of patient was recorded. Organ doses and effective dose for each radiographic projection were calculated for a reference patient. A plan of corrective actions to solve the deficiencies was implemented. It was decided to develop a national quality control program in diagnostic radiology. (Author) 12 refs

  11. Application of sigma metrics for the assessment of quality control in clinical chemistry laboratory in Ghana: A pilot study.

    Science.gov (United States)

    Afrifa, Justice; Gyekye, Seth A; Owiredu, William K B A; Ephraim, Richard K D; Essien-Baidoo, Samuel; Amoah, Samuel; Simpong, David L; Arthur, Aaron R

    2015-01-01

    Sigma metrics provide a uniquely defined scale with which we can assess the performance of a laboratory. The objective of this study was to assess the internal quality control (QC) in the clinical chemistry laboratory of the University of Cape Cost Hospital (UCC) using the six sigma metrics application. We used commercial control serum [normal (L1) and pathological (L2)] for validation of quality control. Metabolites (glucose, urea, and creatinine), lipids [triglycerides (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C)], enzymes [alkaline phosphatase (ALP), alanine aminotransferase (AST)], electrolytes (sodium, potassium, chloride) and total protein were assessed. Between-day imprecision (CVs), inaccuracy (Bias) and sigma values were calculated for each control level. Apart from sodium (2.40%, 3.83%), chloride (2.52% and 2.51%) for both L1 and L2 respectively, and glucose (4.82%), cholesterol (4.86%) for L2, CVs for all other parameters (both L1 and L2) were >5%. Four parameters (HDL-C, urea, creatinine and potassium) achieved sigma levels >1 for both controls. Chloride and sodium achieved sigma levels >1 for L1 but sigma levels 1 for L2. Glucose and ALP achieved a sigma level >1 for both control levels whereas TG achieved a sigma level >2 for both control levels. Unsatisfactory sigma levels (six sigma levels for the laboratory.

  12. Quality control of radiopharmaceuticals

    International Nuclear Information System (INIS)

    Wallen, O.; Komarov, E.

    1973-01-01

    The International Pharmacopoeia published by WHO constitutes a collection of recommended specifications for pharmaceutical preparations which are not intended to have legal status in any country, but serve as references so that national specifications can be established on a similar basis in any country. Like any pharmacopoeia, it contains monographs for the quality con trol of drugs by means of chemical, physical and simple biological methods, as well as appendices describing general methods. The work on the International Pharmacopoeia is carried out by WHO with the aid of the Expert Advisory Panel on the International Pharmacopoeia and Pharmaceutical Preparations and other specialists from various countries and the Expert Committee on Specifications for Pharmaceutical Preparations. (author)

  13. Quality control in breast tomosynthesis

    International Nuclear Information System (INIS)

    Jakubiak, Rosangela Requi; Messias, Pricila Cordeiro; Santos, Marilia Fernanda; Urban, Linei Augusta B.D.

    2014-01-01

    In Brazil breast cancer is the most common and the leading cause of death among women, with estimated 57,000 new cases in 2014. The mammography (2D) plays an important role in the early detection of breast cancer, but in some cases can be difficult to detect malignant lesions due overlap of breast tissues. The Breast Digital Tomosynthesis (BDT: 3D) reduces the effects of overlap, providing improved characterization of mammographic findings. However, the dose may double as compared to the mammography. This study presents results of Contrast Ratio Noise tests (CRN) and quality image on a Siemens mammography equipment Mammomat Inspiration with tomosynthesis. The CRN was determined with plates Polymethylmethacrylate (PMMA) of 20 to 70 mm thickness and an aluminum plate of 10 mm 2 and 0.2 mm thickness. Image quality was assessed with the ACR Breast Simulator. In assessment of image quality, the detectability of fibers and masses was identical in 2D and 3D systems. Were visualized 4.5 fibers and 4 mass in both modes. In 2D mode groups have been identified 3.5 microcalcifications, and 3D were 3 groups. The Mean Glandular Dose for the simulator in 2D mode was 1.17 mGy and 2.35 mGy for the 3D mode. The result reinforces the importance of quality control in the process of obtaining the images and obtained in accordance CRN values, ensuring image quality and dose compatible in 2D and 3D processes

  14. Quality control in breast tomosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Jakubiak, R.R.; Messias, P.C.; Santos, M.F., E-mail: requi@utfpr.edu.br [Universidade Tecnologia Federal do Parana (UTFPR), Curitiba, PR (Brazil). Departamento Academico de Fisica; Urban, L.A.B.D., E-mail: lineiurban@hotmail.com [Diagnostico Avancado por Imagem, Curitiba, PR (Brazil)

    2015-07-01

    In Brazil, breast cancer is the most common and the leading cause of death among women, with estimated 57,000 new cases in 2014. The mammography (2D) plays an important role in the early detection of breast cancer, but in some cases can be difficult to detect malignant lesions due overlap of breast tissues. The Digital Breasts Tomosynthesis (DBT: 3D) reduces the effects of overlap, providing improved characterization of mammographic findings. However, the dose may double as compared with mammography. This study presents results of Contrast to Noise Ratio (CNR) and image quality evaluation on Siemens mammography equipment Mammomat Inspiration with tomosynthesis. The CNR was determined with Polymethylmethacrylate (PMMA) layers of 20 to 70 mm thick and an aluminum foils of 0,2 mm thickness and area of 10 mm². Image quality was assessed with the ACR Breast Simulator. In the evaluation of image quality, the detectability of fibers and masses was identical in 2D and 3D systems. Displaying fibers were 4,5 and 4 mass in both modes. In 2D mode were identified 3,5 microcalcifications groups, and 3D showed 3 groups. The Mean Glandular Dose (MGD) for the simulator in 2D mode was 1,17 mGy and 2,35 mGy for the 3D mode. The result reinforces the importance of quality control in the process of obtaining the images and obtained in accordance CNR values, ensuring image quality and compatible dose in 2D and 3D processes. (author)

  15. Quality control in breast tomosynthesis

    International Nuclear Information System (INIS)

    Jakubiak, R.R.; Messias, P.C.; Santos, M.F.

    2015-01-01

    In Brazil, breast cancer is the most common and the leading cause of death among women, with estimated 57,000 new cases in 2014. The mammography (2D) plays an important role in the early detection of breast cancer, but in some cases can be difficult to detect malignant lesions due overlap of breast tissues. The Digital Breasts Tomosynthesis (DBT: 3D) reduces the effects of overlap, providing improved characterization of mammographic findings. However, the dose may double as compared with mammography. This study presents results of Contrast to Noise Ratio (CNR) and image quality evaluation on Siemens mammography equipment Mammomat Inspiration with tomosynthesis. The CNR was determined with Polymethylmethacrylate (PMMA) layers of 20 to 70 mm thick and an aluminum foils of 0,2 mm thickness and area of 10 mm². Image quality was assessed with the ACR Breast Simulator. In the evaluation of image quality, the detectability of fibers and masses was identical in 2D and 3D systems. Displaying fibers were 4,5 and 4 mass in both modes. In 2D mode were identified 3,5 microcalcifications groups, and 3D showed 3 groups. The Mean Glandular Dose (MGD) for the simulator in 2D mode was 1,17 mGy and 2,35 mGy for the 3D mode. The result reinforces the importance of quality control in the process of obtaining the images and obtained in accordance CNR values, ensuring image quality and compatible dose in 2D and 3D processes. (author)

  16. Relationship of Indoor, Outdoor and Personal Air (RIOPA) study: study design, methods and quality assurance/control results.

    Science.gov (United States)

    Weisel, Clifford P; Zhang, Junfeng; Turpin, Barbara J; Morandi, Maria T; Colome, Steven; Stock, Thomas H; Spektor, Dalia M; Korn, Leo; Winer, Arthur; Alimokhtari, Shahnaz; Kwon, Jaymin; Mohan, Krishnan; Harrington, Robert; Giovanetti, Robert; Cui, William; Afshar, Masoud; Maberti, Silvia; Shendell, Derek

    2005-03-01

    The Relationship of Indoor, Outdoor and Personal Air (RIOPA) Study was undertaken to evaluate the contribution of outdoor sources of air toxics, as defined in the 1990 Clean Air Act Amendments, to indoor concentrations and personal exposures. The concentrations of 18 volatile organic compounds (VOCs), 17 carbonyl compounds, and fine particulate matter mass (PM(2.5)) were measured using 48-h outdoor, indoor and personal air samples collected simultaneously. PM2.5 mass, as well as several component species (elemental carbon, organic carbon, polyaromatic hydrocarbons and elemental analysis) were also measured; only PM(2.5) mass is reported here. Questionnaires were administered to characterize homes, neighborhoods and personal activities that might affect exposures. The air exchange rate was also measured in each home. Homes in close proximity (<0.5 km) to sources of air toxics were preferentially (2:1) selected for sampling. Approximately 100 non-smoking households in each of Elizabeth, NJ, Houston, TX, and Los Angeles, CA were sampled (100, 105, and 105 respectively) with second visits performed at 84, 93, and 81 homes in each city, respectively. VOC samples were collected at all homes, carbonyls at 90% and PM(2.5) at 60% of the homes. Personal samples were collected from nonsmoking adults and a portion of children living in the target homes. This manuscript provides the RIOPA study design and quality control and assurance data. The results from the RIOPA study can potentially provide information on the influence of ambient sources on indoor air concentrations and exposure for many air toxics and will furnish an opportunity to evaluate exposure models for these compounds.

  17. Employee quality, monitoring environment and internal control

    Directory of Open Access Journals (Sweden)

    Chunli Liu

    2017-03-01

    Full Text Available We investigate the effect of internal control employees (ICEs on internal control quality. Using special survey data from Chinese listed firms, we find that ICE quality has a significant positive influence on internal control quality. We examine the effect of monitoring on this result and find that the effect is more pronounced for firms with strict monitoring environments, especially when the firms implement the Chinese internal control regulation system (CSOX, have higher institutional ownership or attach greater importance to internal control. Our findings suggest that ICEs play an important role in the design and implementation of internal control systems. Our study should be of interest to both top managers who wish to improve corporate internal control quality and regulators who wish to understand the mechanisms of internal control monitoring.

  18. Quality control of labelled compounds

    International Nuclear Information System (INIS)

    Matucha, M.

    1979-01-01

    Some advantages and disadvantages of methods used for quality control of organic labelled compounds (1 31 I, 14 C) are shortly discussed. The methods used are electrophoresis, ultraviolet and infrared spectrometry, radiogas and thin-layer chromatography. (author)

  19. Perioperative Care and the Importance of Continuous Quality Improvement--A Controlled Intervention Study in Three Tanzanian Hospitals.

    Science.gov (United States)

    Bosse, Goetz; Abels, Wiltrud; Mtatifikolo, Ferdinand; Ngoli, Baltazar; Neuner, Bruno; Wernecke, Klaus-Dieter; Spies, Claudia

    2015-01-01

    Surgical services are increasingly seen to reduce death and disability in Sub-Saharan Africa, where hospital-based mortality remains alarmingly high. This study explores two implementation approaches to improve the quality of perioperative care in a Tanzanian hospital. Effects were compared to a control group of two other hospitals in the region without intervention. All hospitals conducted quality assessments with a Hospital Performance Assessment Tool. Changes in immediate outcome indicators after one and two years were compared to final outcome indicators such as Anaesthetic Complication Rate and Surgical Case Fatality Rate. Immediate outcome indicators for Preoperative Care in the intervention hospital improved (52.5% in 2009; 84.2% in 2011, pcontrol group, preoperative care declined from 50.8% (2009) to 32.8% (2011, p hospital declined (1.89% before intervention; 0.96% after intervention, p = 0.006). Surgical Case Fatality Rate in the intervention hospital declined from 5.67% before intervention to 2.93% after intervention (pcontrol group was 4% before intervention and 3.8% after intervention (p = 0.411). Anaesthetic Complication Rate in the control group was not available. Immediate outcome indicators initially improved, while at the same time final outcome declined (Surgical Case Fatality, Anaesthetic Complication Rate). Compared to the control group, final outcome improved more in the intervention hospital, although the effect was not significant over the whole study period. Documentation of final outcome indicators seemed inconsistent. Immediate outcome indicators seem more helpful to steer the Continuous Quality Improvement program. Specific interventions as part of Continuous Quality Improvement might lead to sustainable improvement of the quality of care, if embedded in a multi-faceted approach.

  20. Quality of life in children with infantile hemangioma: a case control study.

    Science.gov (United States)

    Wang, Chuan; Li, Yanan; Xiang, Bo; Xiong, Fei; Li, Kai; Yang, Kaiying; Chen, Siyuan; Ji, Yi

    2017-11-16

    Infantile hemangioma (IH) is the most common vascular tumor in children. It is controversial whether IHs has effects on the quality of life (QOL) in patients of whom IH poses no threat or potential for complication. Thus, we conducted this study to evaluate the q QOL in patients with IH and find the predictors of poor QOL. The PedsQL 4.0 Genetic Core Scales and the PedsQL family information form were administered to parents of children with IH and healthy children both younger than 2-year-old. The quality-of-life instrument for IH (IH-QOL) and the PedsQL 4.0 family impact module were administered to parents of children with IH. We compared the PedsQL 4.0 Genetic Core Scales (GCIS) scores of the two groups. Multiple step-wise regression analysis was used to determine factors that influenced QOL in children with IH and their parents. Except for physical symptom, we found no significant difference in GCIS between patient group and healthy group (P = 0.409). The internal reliability of IH-QOL was excellent with the Cronbach's alpha coefficient for summary scores being 0.76. Multiple step-wise regression analysis showed that the predictors of poor IH-QOL total scores were hemangioma size, location, and mother's education level. The predictors of poor FIM total scores were hemangioma location and father's education level. The predictors of poor GCIS total scores were children's age, hemangioma location and father's education level. The findings support the feasibility and reliability of the Chinese version of IH-QOL to evaluate the QOL in children with IH and their parents. Hemangioma size, location and education level of mother are important impact factors for QOL in children with IH and their parents.

  1. [Quality control in herbal supplements].

    Science.gov (United States)

    Oelker, Luisa

    2005-01-01

    Quality and safety of food and herbal supplements are the result of a whole of different elements as good manufacturing practice and process control. The process control must be active and able to individuate and correct all possible hazards. The main and most utilized instrument is the hazard analysis critical control point (HACCP) system the correct application of which can guarantee the safety of the product. Herbal supplements need, in addition to standard quality control, a set of checks to assure the harmlessness and safety of the plants used.

  2. Fuel cycle and quality control

    International Nuclear Information System (INIS)

    Stoll, W.

    1979-01-01

    The volume of the fuel cycle is described in its economic importance and its through put, as it is envisaged for the Federal Republic of Germany. Definitions are given for quality continuing usefulness of an object and translated into quality criteria. Requirements on performance of fuel elements are defined. The way in which experimental results are translated into mass production of fuel rods, is described. The economic potential for further quality effort is derived. Future ways of development for quality control organisation and structure are outlined. (Auth.)

  3. Oral health-related quality of life in Iranian patients with spinal cord injury: A case-control study.

    Science.gov (United States)

    Pakpour, Amir H; Kumar, Santhosh; Scheerman, Janneke F M; Lin, Chung-Ying; Fridlund, Bengt; Jansson, Henrik

    2016-06-01

    The study aimed to compare the oral health variables, general, and oral health-related quality of life (QoL), depression, and anxiety between spinal cord injury (SCI) patients and healthy controls and also to determine the key factors related to the oral health-related quality of life (OHRQoL) in the SCI patients. A total of 203 SCI patients and 203 healthy controls were enrolled. Patients and healthy adults were invited to attend a dental clinic to complete the study measures and undergo oral clinical examinations. OHRQoL was assessed by the 14-item Oral Health Impact Profile (OHIP-14), and the general health-related quality of life (GHRQoL) was evaluated by SF-36. In SCI patients, depression and anxiety were recorded using the Hospital Anxiety and Depression Scale (HADS), while Functional Assessment Measure (FAM) was used to assess dependence and disability. All the subjects were examined for caries which was quantified using the decayed, missing, and filled Teeth (DMFT) index, gingival bleeding index (GI), plaque index, and periodontal status by community periodontal index (CPI). The analysis of covariance (ANCOVA) revealed significant differences between the two groups in terms of oral health expressed in DMFT, oral hygiene, and periodontal status, controlled for age, gender, family income, and occupational status (poral hygiene practices, greater levels of plaque, gingival bleeding, and caries experience than the healthy controls. In addition, more number of SCI patients had periodontal pockets and dry mouth than the comparative group. SCI patients experienced more depression and anxiety, poor GHRQoL, and OHRQoL than the healthy control group. The factors that influenced OHRQoL in SCI patients were age, toothbrushing frequency, smoking, oral clinical status, depression, physical component of GHRQoL, and level of lesion. Copyright © 2016 Elsevier Ltd. All rights reserved.

  4. The Development of Quality Control Genotyping Approaches: A Case Study Using Elite Maize Lines.

    Directory of Open Access Journals (Sweden)

    Jiafa Chen

    Full Text Available Quality control (QC of germplasm identity and purity is a critical component of breeding and conservation activities. SNP genotyping technologies and increased availability of markers provide the opportunity to employ genotyping as a low-cost and robust component of this QC. In the public sector available low-cost SNP QC genotyping methods have been developed from a very limited panel of markers of 1,000 to 1,500 markers without broad selection of the most informative SNPs. Selection of optimal SNPs and definition of appropriate germplasm sampling in addition to platform section impact on logistical and resource-use considerations for breeding and conservation applications when mainstreaming QC. In order to address these issues, we evaluated the selection and use of SNPs for QC applications from large DArTSeq data sets generated from CIMMYT maize inbred lines (CMLs. Two QC genotyping strategies were developed, the first is a "rapid QC", employing a small number of SNPs to identify potential mislabeling of seed packages or plots, the second is a "broad QC", employing a larger number of SNP, used to identify each germplasm entry and to measure heterogeneity. The optimal marker selection strategies combined the selection of markers with high minor allele frequency, sampling of clustered SNP in proportion to marker cluster distance and selecting markers that maintain a uniform genomic distribution. The rapid and broad QC SNP panels selected using this approach were further validated using blind test assessments of related re-generation samples. The influence of sampling within each line was evaluated. Sampling 192 individuals would result in close to 100% possibility of detecting a 5% contamination in the entry, and approximately a 98% probability to detect a 2% contamination of the line. These results provide a framework for the establishment of QC genotyping. A comparison of financial and time costs for use of these approaches across different

  5. Summer program Report : Quality control and Aging study for the GE1/1 detectors in CMS Muon endcap upgrade

    CERN Document Server

    Rajan, Adithya

    2017-01-01

    In this report, I summarize the work I did during my tenure in the Summer program. The project started with conducting three quality controls -- gas leak test, High Voltage test and Gas gain test. These are necessary to check if the GE1/1 detectors pass the requirements necessary for its deployment in the CMS. Then, I explain how aging study of the detectors was conducted and how the data was analyzed to ascertain if the detector has undergone aging. Lastly, the ongoing process of setting up a further accelerated aging study within the GEM lab is explained, with some potential difficulties associated with it.

  6. Principles and Practices for Quality Assurance and Quality Control

    Science.gov (United States)

    Jones, Berwyn E.

    1999-01-01

    Quality assurance and quality control are vital parts of highway runoff water-quality monitoring projects. To be effective, project quality assurance must address all aspects of the project, including project management responsibilities and resources, data quality objectives, sampling and analysis plans, data-collection protocols, data quality-control plans, data-assessment procedures and requirements, and project outputs. Quality control ensures that the data quality objectives are achieved as planned. The historical development and current state of the art of quality assurance and quality control concepts described in this report can be applied to evaluation of data from prior projects.

  7. Internal service quality by integrated approach Performance Control Matrix (PCM & Importance-Satisfaction Model (Studied in Yazd Regional Power Company

    Directory of Open Access Journals (Sweden)

    Saeid Peirow

    2016-02-01

    Full Text Available Today, the internal service quality as one of the most important factors affecting the recruitment and retention of staff is considered. The present study sought to examine the internal service quality of Yazd Regional Electric, finally, select appropriate strategies to improve the quality of local services in the organization. The application of this study is base on survey method.Data were collected from questionnaires to evaluate the 26 components of internal service quality of Yazd Regional Electric, has been used. Research community is the staff of the organisation.Also, the sample size, the initial questionnaire was distributed according to Cochran's formula is calculated.In order to analyze research data, the model is important - satisfaction and performance control matrix to identify those components that are used need to be improved.Also, in order to prioritize measures to improve employee satisfaction index is used. Data analysis using above tools show, 8 criteria are in improvment area. So, these criteria are prioritized with ESI.

  8. Quality of life and self-esteem in patients with paraplegia and pressure ulcers: a controlled cross-sectional study.

    Science.gov (United States)

    Lourenco, L; Blanes, L; Salomé, G M; Ferreira, L M

    2014-06-01

    To evaluate health-related quality of life (HRQoL) and self-esteem in patients with traumatic spinal cord injury (SCI) and pressure ulcers. This study was a controlled cross-sectional study. HRQoL was assessed using the generic Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) questionnaire and the Rosenberg Self-Esteem/UNIFESP-EPM Scale. A total of 120 patients with traumatic SCI were included in the sample, of which 60 had pressure ulcers and were assigned to the study group, and 60 had no pressure ulcers and were assigned to the control group. Statistical analysis was performed using the chi-square test, Fisher's exact test, and Student's t-test. Of the 60 patients in the study group, 83.3% were men and the mean age was 38.17 years (SD = 9.08 years). When compared with controls, patients in the study group reported significantly lower scores (worse health status) on all SF-36 subscales (p less than or equal to 0.0013) except for general health (p=0.109). The RSE/UNIFESP-EMP scale total score indicated that patients with pressure ulcers had significantly lower self-esteem than controls (p<0.001). Pressure ulcers had an adverse impact on the HRQoL and self-esteem of patients with SCI. There were no external sources of funding for this study. The authors have no conflicts of interest to declare.

  9. [Evaluation of the "initiative pain-free clinic" for quality improvement in postoperative pain management. A prospective controlled study].

    Science.gov (United States)

    Lehmkuhl, D; Meissner, W; Neugebauer, E A M

    2011-09-01

    Demonstration of improved postoperative pain management by implementation of the S3 guidelines on treatment of acute perioperative and posttraumatic pain, by the integrated quality management concept "quality management acute pain" of the TÜV Rheinland or by participation in the benchmark project "Quality improvement in postoperative pain management" (QUIPS). A prospective controlled study (pre-post design) was carried out in hospitals with various levels of care comparing three hospital groups (n = 17/7/3, respectively). Group 1: participation in the QUIPS project (intraclinic and interclinic comparison of outcome data of postoperative pain treatment), group 2: participation in the quality management acute pain program (certified by TÜV Rheinland), group 3: control group with no involvement in either of the two concepts. In all three groups, an anonymous data collection was performed consisting of patient-reported pain intensity, side effects, pain disability and patient satisfaction. Pain therapy intervention was carried out only in group 2 by an integrated quality management concept (certification project: Quality management acute pain) with a package of measures to improve structure, process and outcome quality. The TÜV Rheinland certified clinics (group 2) showed a significant improvement in the pre-post comparison (before versus after certification) in the areas maximum pain (from visual analogue scale VAS 4.6 to 3.7), stress pain (5.3 to 3.9), pain-related impairment (proportion of patients with pain-linked decreased mobility and movement 26% to 16.1%, coughing and breathing 23.1% to 14.3%) and patient satisfaction (from 13.2 to 13.7; scale 0 completely unsatisfied, 15 very satisfied). The clinics with participation in QUIPS for 2 years also showed a significant improvement in stress pain (numeric rating scale NRS for pain 4.5 to 4.2), pain-linked-limitation of coughing and breathing (28% to 23.6%), and patient satisfaction (from 11.9 to 12.4). There were

  10. Effects of tai chi chuan on anxiety and sleep quality in young adults: lessons from a randomized controlled feasibility study

    Directory of Open Access Journals (Sweden)

    Caldwell KL

    2016-11-01

    in young adults. Keywords: anxiety, sleep quality, tai chi chuan, randomized controlled trial, feasibility study

  11. Habitual diet and diet quality in Irritable Bowel Syndrome : A case-control study

    NARCIS (Netherlands)

    Tigchelaar, E. F.; Mujagic, Z.; Zhernakova, A.; Hesselink, M. A. M.; Meijboom, S.; Perenboom, C. W. M.; Masclee, A. A. M.; Wijmenga, C.; Feskens, E. J. M.; Jonkers, D. M. A. E.

    2017-01-01

    Background: Diet is considered to be a key factor in symptom generation in Irritable Bowel Syndrome (IBS) and patients tend to exclude food products from their diet in pursue of symptom relief, which may impair diet quality. Methods: We evaluated habitual dietary intake in IBS patients with regard

  12. Quality control of imaging devices

    International Nuclear Information System (INIS)

    Soni, P.S.

    1992-01-01

    Quality assurance in nuclear medicine refers collectively to all aspects of a nuclear medicine service. It would include patient scheduling, radiopharmaceutical preparation and dispensing, radiation protection of patients, staff and general public, preventive maintenance and the care of instruments, methodology, data interpretation and records keeping, and many other small things which contribute directly or indirectly to the overall quality of a nuclear medicine service in a hospital. Quality Control, on the other hand, refers to a signal component of the system and is usually applied in relation to a specific instrument and its performance

  13. Sensory modulation and sleep quality among adults with learning disabilities: a quasi-experimental case-control design study.

    Directory of Open Access Journals (Sweden)

    Kineret Sharfi

    Full Text Available Following the International Classification of Functioning, Disability and Health (ICF concepts, this study examines body functions such as sensory modulation and sleep quality among adults with learning disabilities (LD.One hundred and ten participants, 55 adults with LD and 55 matched controls (mean age 30 years filled in a socio-demographic questionnaire, the Adults/Adolescents Sensory Profile (AASP, and the Mini Sleep Questionnaire (MSQ. Chi-tests, Mann-Whitney tests, and Kolmogorov-Smirnov tests were conducted to examine group differences related to socio-demographic characteristics and body functions. Correlation and regression analyses were conducted to examine relationships between body functions.Significant differences were found between the groups in: (a unique socio-demographic variables: high-schools attended, family status and number of children; (b body functions: low registration and sensory sensitivity (p < .001, sensory avoiding (p = .002, sensory seeking (p = .021 and sleep quality (p < .001. Significant correlations were found between AASP subscale scores and the MSQ final score in each group. Regression analysis revealed that for the entire sample (N = 108, low registration accounted for 10.2% of the variance of sleep quality above group membership (p < .001, while in a separate examination of adults with LD (n = 53, low registration accounted for 19.9% of the variance of sleep quality (p < .001.Adults with LD need to be studied through a health-related perspective such as the ICF model to gain further understanding of their unique characteristics and daily needs. Sensory and sleep functions of adults with LD should be further studied in the context of health related quality of life.

  14. Quality control for dose calibrators

    International Nuclear Information System (INIS)

    Mendes, L.C.G.

    1984-01-01

    Nuclear medicine laboratories are required to assay samples of radioactivity to be administered to patients. Almost universally, these assays are accomplished by use of a well ionization chamber isotope calibrator. The Instituto de Radioprotecao e Dosimetria (Institute for Radiological Protection and Dosimetry) of the Comissao Nacional de Energia Nuclear (National Commission for Nuclear Energy) is carrying out a National Quality Control Programme in Nuclear Medicine, supported by the International Atomic Energy Agency. The assessment of the current needs and practices of quality control in the entire country of Brazil includes Dose Calibrators and Scintillation Cameras, but this manual is restricted to the former. Quality Control Procedures for these Instruments are described in this document together with specific recommendations and assessment of its accuracy. (author)

  15. Is Low-field NMR a Complementary Tool to GC-MS in Quality Control of Essential Oils? A Case Study

    NARCIS (Netherlands)

    Krause, Andre; Wu, Yu; Tian, Runtao; Beek, van Teris A.

    2018-01-01

    High-field NMR is an expensive and important quality control technique. In recent years, cheaper and simpler low-field NMR has become available as a new quality control technique. In this study, 60 MHz 1 H-NMR was compared with GC-MS and refractometry for the detection of adulteration of essential

  16. Geochemical processes controlling groundwater quality under semi arid environment: A case study in central Morocco.

    Science.gov (United States)

    Karroum, Morad; Elgettafi, Mohammed; Elmandour, Abdenabi; Wilske, Cornelia; Himi, Mahjoub; Casas, Albert

    2017-12-31

    Bahira plain is an important area for Morocco due to its agriculture and mining activities. Situated in a sub-arid to arid climate, this plain hosts an aquifer system that represents sequences of carbonates, phosphates, evaporates and alluvial deposits. Groundwater flows from Ganntour plateau (recharge area) to the basin-fill deposits and Zima Lake and Sed Elmejnoun where water evaporates. The objective of this study was to characterize the chemical properties of the groundwater and to assess the processes controlling the groundwater's chemistry. We can divide water samples into three hydrochemical water groups: recharge waters (Ca/Mg-HCO 3 ), transition zone waters (Ca-HCO 3 -SO 4 /Cl) and discharge waters (Na-Cl/SO 4 ). Accordingly, compositions of waters are determined by the availability of easily soluble minerals like calcite (Ca-HCO 3 dominant), halite (Na-Cl dominant) and gypsum (Ca-SO 4 dominant). Cl/Br ratios show that Cl concentration increases from dissolution of natural halite. When groundwater is affected by extreme evaporation Cl/Br ratios may increase up to 1900. High fluoride concentrations are associated with low Ca 2+ concentrations (<100mg/L). That means when recharge waters enter the aquifer, it starts dissolving fluorite since the Ca 2+ concentration is low. Once groundwater becomes saturated with Ca 2+ , the immobilization of fluoride is occurring by precipitation of fluoride-rich minerals like fluoro-apatite. According to the environmental isotope ( 18 O and 2 H) analyses, they are three potential processes affecting groundwater: 1. Evaporation as verified by low slope value, 2. Water-rock interaction, 3. admixture of waters showed different stable isotope compositions and salinities. Copyright © 2017 Elsevier B.V. All rights reserved.

  17. Diet Quality of patients with chronic Chagas disease in a tertiary hospital: a case-control study

    Directory of Open Access Journals (Sweden)

    Mariana Pereira de Castilhos

    Full Text Available Abstract INTRODUCTION: Nutritional status has been implicated in the modulation of the immune response, possibly augmenting the pathogenesis of Chagas disease (Cd. We evaluated diet quality and nutritional status in adults and elderly patients with chronic Cd in a tertiary hospital. METHODS: A case-control study of Cd patients was conducted, paired for gender, age, and co-morbidities with non-Cd patients. Anthropometric measurements and food frequency questionnaire was used, and diet quality was assessed by the Brazilian Healthy Eating Index-Revised (BHEI-R. The Estimated Average Requirement cut-off points were used to determine the dietary micronutrient adequacy. The Cd group was further grouped according to Los Andes classification. RESULTS: The study participants were 67 ± 10 years old, 73.6% elderly and 63% female. The prevalence of overweight/obesity and abdominal fat was high in both groups; however, Cd group showed a lower prevalence of obesity and increased risk of disease according to waist circumference classification. There was no difference in BHEI-R score between groups (p=0.145. The Cd group had sodium and saturated fat intake above recommendations and low intake of unsaturated fat, vitamin D, E, selenium, magnesium, and dairy products; but higher intake of iron. According to Los Andes classification, group III presented lower intake of whole fruit and dietary fiber. CONCLUSIONS: Patients with Cd were overweight and the quality of their diet was unsatisfactory based on the recommended diet components for age and sex.

  18. Using clinical indicators to facilitate quality improvement via the accreditation process: an adaptive study into the control relationship.

    Science.gov (United States)

    Chuang, Sheuwen; Howley, Peter P; Hancock, Stephen

    2013-07-01

    The aim of the study was to determine accreditation surveyors' and hospitals' use and perceived usefulness of clinical indicator reports and the potential to establish the control relationship between the accreditation and reporting systems. The control relationship refers to instructional directives, arising from appropriately designed methods and efforts towards using clinical indicators, which provide a directed moderating, balancing and best outcome for the connected systems. Web-based questionnaire survey. Australian Council on Healthcare Standards' (ACHS) accreditation and clinical indicator programmes. Seventy-three of 306 surveyors responded. Half used the reports always/most of the time. Five key messages were revealed: (i) report use was related to availability before on-site investigation; (ii) report use was associated with the use of non-ACHS reports; (iii) a clinical indicator set's perceived usefulness was associated with its reporting volume across hospitals; (iv) simpler measures and visual summaries in reports were rated the most useful; (v) reports were deemed to be suitable for the quality and safety objectives of the key groups of interested parties (hospitals' senior executive and management officers, clinicians, quality managers and surveyors). Implementing the control relationship between the reporting and accreditation systems is a promising expectation. Redesigning processes to ensure reports are available in pre-survey packages and refined education of surveyors and hospitals on how to better utilize the reports will support the relationship. Additional studies on the systems' theory-based model of the accreditation and reporting system are warranted to establish the control relationship, building integrated system-wide relationships with sustainable and improved outcomes.

  19. Foot health-related quality of life among elderly with and without lesser toe deformities: a case–control study

    Directory of Open Access Journals (Sweden)

    López-López D

    2018-02-01

    Full Text Available Daniel López-López,1 María Martínez-Vázquez,1 Marta Elena Losa-Iglesias,2 César Calvo-Lobo,3 David Rodríguez-Sanz,4 Patricia Palomo-López,5 Ricardo Becerro-de-Bengoa-Vallejo6 1Research, Health and Podiatry Unit, Department of Health Sciences, Faculty of Nursing and Podiatry, Universidade da Coruña, Ferrol, Spain; 2Faculty of Health Sciences, Universidad Rey Juan Carlos, Madrid, Spain; 3Nursing and Physical Therapy Department, Institute of Biomedicine (IBIOMED, Universidad de León, Ponferrada, León, Spain; 4School of Sports Science, European University, Villaviciosa de Odón, Madrid, Spain; 5University Center of Plasencia, Universidad de Extremadura, Extremadura, Spain; 6School of Nursing, Physiotherapy and Podiatry, Universidad Complutense de Madrid, Madrid, Spain Purpose: The aim of this study was to compare the health-related quality of life impact related to foot health and health in general in older adults with lesser toe deformities (LTD and without any foot conditions. Methods: A case–control observational study was carried out following the Strengthening the Reporting of Observational Studies in Epidemiology criteria. A total of 100 older adults with a mean age of 74.39±6.02 years were recruited at an outpatient clinic; 50 of these subjects had LTD (case group and 50 subjects were without any foot conditions (control group. Presence of LTD was determined in both feet using the Kelikian push-up test, and the Foot Health Status Questionnaire scores were self-reported.Results: The case group showed lower scores in quality of life in relation to health in general and to foot health specifically. Statistically significant differences (p<0.05 between case and control groups were shown by means of the Wicoxon test.Conclusion: A negative impact in quality of life in relation to foot health should be considered in older adults with LTD, regardless of gender. Keywords: aged, foot deformities, foot disease, quality of life, toes

  20. Quality assurance and statistical control

    DEFF Research Database (Denmark)

    Heydorn, K.

    1991-01-01

    In scientific research laboratories it is rarely possible to use quality assurance schemes, developed for large-scale analysis. Instead methods have been developed to control the quality of modest numbers of analytical results by relying on statistical control: Analysis of precision serves...... to detect analytical errors by comparing the a priori precision of the analytical results with the actual variability observed among replicates or duplicates. The method relies on the chi-square distribution to detect excess variability and is quite sensitive even for 5-10 results. Interference control...... serves to detect analytical bias by comparing results obtained by two different analytical methods, each relying on a different detection principle and therefore exhibiting different influence from matrix elements; only 5-10 sets of results are required to establish whether a regression line passes...

  1. Use of multiple sensor technologies for quality control of in situ biogeochemical measurements: A SeaCycler case study

    Science.gov (United States)

    Atamanchuk, Dariia; Koelling, Jannes; Lai, Jeremy; Send, Uwe; Wallace, Douglas

    2017-04-01

    Over the last two decades observing capacity for the global ocean has increased dramatically. Emerging sensor technologies for dissolved gases, nutrients and bio-optical properties in seawater are allowing extension of in situ observations beyond the traditionally measured salinity, temperature and pressure (CTD). However the effort to extend observations using autonomous instruments and platforms carries the risk of losing the level of data quality achievable through conventional water sampling techniques. We will present results from a case study with the SeaCycler profiling winch focusing on quality control of the in-situ measurements. A total of 13 sensors were deployed from May 2016 to early 2017 on SeaCycler's profiling sensor float, including CTD, dissolved oxygen (O2, 3 sensors), carbon dioxide (pCO2, 2 sensors), nutrients, velocity sensors, fluorometer, transmissometer, single channel PAR sensor, and others. We will highlight how multiple measurement technologies (e.g. for O2 and CO2) complement each other and result in a high quality data product. We will also present an initial assessment of the bio-optical data, their implications for seasonal phytoplankton dynamics and comparisons to climatologies and ocean-color data products obtained from the MODIS satellite.

  2. Study protocol of a multicenter randomized controlled trial of mindfulness training to reduce burnout and promote quality of life in police officers: the POLICE study.

    Science.gov (United States)

    Trombka, Marcelo; Demarzo, Marcelo; Bacas, Daniel Campos; Antonio, Sonia Beira; Cicuto, Karen; Salvo, Vera; Claudino, Felipe Cesar Almeida; Ribeiro, Letícia; Christopher, Michael; Garcia-Campayo, Javier; Rocha, Neusa Sica

    2018-05-25

    Police officers experience a high degree of chronic stress. Policing ranks among the highest professions in terms of disease and accident rates. Mental health is particularly impacted, evidenced by elevated rates of burnout, anxiety and depression, and poorer quality of life than the general public. Mindfulness training has been shown to reduce stress, anxiety, burnout and promote quality of life in a variety of settings, although its efficacy in this context has yet to be systematically evaluated. Therefore, this trial will investigate the efficacy of a mindfulness-based intervention versus a waitlist control in improving quality of life and reducing negative mental health symptoms in police officers. This multicenter randomized controlled trial has three assessment points: baseline, post-intervention, and six-month follow-up. Active police officers (n = 160) will be randomized to Mindfulness-Based Health Promotion (MBHP) or waitlist control group at two Brazilian major cities: Porto Alegre and São Paulo. The primary outcomes are burnout symptoms and quality of life. Consistent with the MBHP conceptual model, assessed secondary outcomes include perceived stress, anxiety and depression symptoms, and the potential mechanisms of resilience, mindfulness, decentering, self-compassion, spirituality, and religiosity. Findings from this study will inform and guide future research, practice, and policy regarding police offer health and quality of life in Brazil and globally. ClinicalTrials.gov NCT03114605 . Retrospectively registered on March 21, 2017.

  3. Quality control in tile production

    Science.gov (United States)

    Kalviainen, Heikki A.; Kukkonen, Saku; Hyvarinen, Timo S.; Parkkinen, Jussi P. S.

    1998-10-01

    This work studies visual quality control in ceramics industry. In tile manufacturing, it is important that in each set of tiles, every single tile looks similar. For example, the tiles should have similar color and texture. Our goal is to design a machine vision system that can estimate the sufficient similarity or same appearance to the human eye. Currently, the estimation is usually done by human vision. Differing from other approaches our aim is to use accurate spectral representation of color, and we are comparing spectral features to the RGB color features. A laboratory system for color measurement is built. Experimentations with five classes of brown tiles are presented. We use chromaticity RGB features and several spectral features for classification with the k-NN classifier and with a neural network, called Self-Organizing Map. We can classify many of the tiles but there are several problems that need further investigations: larger training and test sets are needed, illuminations effects must be studied further, and more suitable spectral features are needed with more sophisticated classifiers. It is also interesting to develop further the neural approach.

  4. Quality Assurance/Quality Control Jobs

    Science.gov (United States)

    Fanslau, Melody; Young, Janelle

    The production of a quality and safe food product is essential to the success of any food manufacturing facility. Because of this great importance, a career in quality can be extremely rewarding. Without happy customers willing to buy a product, a company would not be able to survive. Quality issues such as foreign objects, spoiled or mislabeled product, failure to meet net weight requirements, or a recall can all turn customers away from buying a product. The food industry is a customer-driven market in which some consumers are brand loyal based on a history of high quality or in which a single bad experience with a product will turn them away for a lifetime. With this said, the main role of a quality department is to help ensure that quality issues such as these are eliminated or kept to a minimum to maintain or increase the number of customers purchasing their product.

  5. Quality of Life Enhancement Programme for Individuals with Mood Disorder: A Randomized Controlled Pilot Study

    Directory of Open Access Journals (Sweden)

    Yun-Ling Chen

    2015-06-01

    Conclusion: The participants who received the 8-week QOLEP demonstrated significant improvement in the level of depression. Studies with a sample size of at least 104 participants are recommended in the future.

  6. Network-based production quality control

    Science.gov (United States)

    Kwon, Yongjin; Tseng, Bill; Chiou, Richard

    2007-09-01

    This study investigates the feasibility of remote quality control using a host of advanced automation equipment with Internet accessibility. Recent emphasis on product quality and reduction of waste stems from the dynamic, globalized and customer-driven market, which brings opportunities and threats to companies, depending on the response speed and production strategies. The current trends in industry also include a wide spread of distributed manufacturing systems, where design, production, and management facilities are geographically dispersed. This situation mandates not only the accessibility to remotely located production equipment for monitoring and control, but efficient means of responding to changing environment to counter process variations and diverse customer demands. To compete under such an environment, companies are striving to achieve 100%, sensor-based, automated inspection for zero-defect manufacturing. In this study, the Internet-based quality control scheme is referred to as "E-Quality for Manufacturing" or "EQM" for short. By its definition, EQM refers to a holistic approach to design and to embed efficient quality control functions in the context of network integrated manufacturing systems. Such system let designers located far away from the production facility to monitor, control and adjust the quality inspection processes as production design evolves.

  7. Visualization of regulations to support design and quality control--a long-term study.

    Science.gov (United States)

    Blomé, Mikael

    2012-01-01

    The aim of the study was to visualize design regulations of furniture by means of interactive technology based on earlier studies and practical examples. The usage of the visualized regulations was evaluated on two occasions: at the start when the first set of regulations was presented, and after six years of usage of all regulations. The visualized regulations were the result of a design process involving experts and potential users in collaboration with IKEA of Sweden AB. The evaluations by the different users showed a very positive response to using visualized regulations. The participative approach, combining expertise in specific regulations with visualization of guidelines, resulted in clear presentations of important regulations, and great attitudes among the users. These kinds of visualizations have proved to be applicable in a variety of product areas at IKEA, with a potential for further dissemination. It is likely that the approaches to design and visualized regulations in this case study could function in other branches.

  8. Radiation measurements and quality control

    International Nuclear Information System (INIS)

    McLaughlin, W.L.

    1977-01-01

    Accurate measurements are essential to research leading to a successful radiation process and to the commissioning of the process and the facility. On the other hand, once the process is in production, the importance to quality control of measuring radiation quantities (i.e., absorbed dose, dose rate, dose distribution) rather than various other parameters of the process (i.e. conveyor speed, dwell time, radiation field characteristics, product dimensions) is not clearly established. When the safety of the product is determined by the magnitude of the administered dose, as in radiation sterilization, waste control, or food preservation, accuracy and precision of the measurement of the effective dose are vital. Since physical dose measurements are usually simpler, more reliable and reproducible than biological testing of the product, there is a trend toward using standardized dosimetry for quality control of some processes. In many industrial products, however, such as vulcanized rubber, textiles, plastics, coatings, films, wire and cable, the effective dose can be controlled satisfactorily by controlling process variables or by product testing itself. In the measurement of radiation dose profiles by dosimetry, it is necessary to have suitable dose meter calibrations, to account for sources of error and imprecision, and to use correct statistical procedures in specifying dwell times or conveyor speeds and source and product parameters to achieve minimum and maximum doses within specifications. (author)

  9. Metrology and quality control handbook

    International Nuclear Information System (INIS)

    Hofmann, D.

    1983-01-01

    This book tries to present the fundamentals of metrology and quality control in brief surveys. Compromises had to be made in order to reduce the material available to a sensible volume for the sake of clarity. This becomes evident by the following two restrictions which had to made: First, in dealing with the theoretical principles of metrology and quality control, mere reference had to be made in many cases to the great variety of special literature without discussing it to explain further details. Second, in dealing with the application of metrology and quality control techniques in practice, only the basic qantities of the International System of Units (SI) could be taken into account as a rule. Some readers will note that many special measuring methods and equipment known to them are not included in this book. I do hope, however, that this short-coming will show to have a positive effect, too. This book will show the reader how to find the basic quantities and units from the derived quantities and units, and the steps that are necessary to solve any kind of measuring task. (orig./RW) [de

  10. European external quality control study on the competence of laboratories to recognize rare sequence variants resulting in unusual genotyping results.

    Science.gov (United States)

    Márki-Zay, János; Klein, Christoph L; Gancberg, David; Schimmel, Heinz G; Dux, László

    2009-04-01

    Depending on the method used, rare sequence variants adjacent to the single nucleotide polymorphism (SNP) of interest may cause unusual or erroneous genotyping results. Because such rare variants are known for many genes commonly tested in diagnostic laboratories, we organized a proficiency study to assess their influence on the accuracy of reported laboratory results. Four external quality control materials were processed and sent to 283 laboratories through 3 EQA organizers for analysis of the prothrombin 20210G>A mutation. Two of these quality control materials contained sequence variants introduced by site-directed mutagenesis. One hundred eighty-nine laboratories participated in the study. When samples gave a usual result with the method applied, the error rate was 5.1%. Detailed analysis showed that more than 70% of the failures were reported from only 9 laboratories. Allele-specific amplification-based PCR had a much higher error rate than other methods (18.3% vs 2.9%). The variants 20209C>T and [20175T>G; 20179_20180delAC] resulted in unusual genotyping results in 67 and 85 laboratories, respectively. Eighty-three (54.6%) of these unusual results were not recognized, 32 (21.1%) were attributed to technical issues, and only 37 (24.3%) were recognized as another sequence variant. Our findings revealed that some of the participating laboratories were not able to recognize and correctly interpret unusual genotyping results caused by rare SNPs. Our study indicates that the majority of the failures could be avoided by improved training and careful selection and validation of the methods applied.

  11. A study on manufacturing and quality control technology of DUPIC fuel

    International Nuclear Information System (INIS)

    Yang, Myung Seung; Park, H. S.; Lee, Y. W.

    1997-09-01

    A series of experiments are performed to verify the manufacturability of DUPIC fuel and its performance by use of HANARO test reactor. Major works performed during this research period are : analysis of manufacturing process of DUPIC fuel, fabrication technology development such as development of disassembly and decladding method of spent PWR fuel, study on the OREOX process using simulated high burnup fuel, weldability of end cap weld, and development of fabrication equipment including the conceptual and detailed design of DUPIC equipment mainly for the powder preparation, pelletization and fuel element fabrication. A study on the material properties of DUPIC fuel and performance analysis method using irradiation of test fuel was also performed. (author). 91 refs., 274 tabs., 254 figs

  12. A study on manufacturing and quality control technology of DUPIC fuel

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Myung Seung; Park, H. S.; Lee, Y. W. [and others

    1997-09-01

    A series of experiments are performed to verify the manufacturability of DUPIC fuel and its performance by use of HANARO test reactor. Major works performed during this research period are : analysis of manufacturing process of DUPIC fuel, fabrication technology development such as development of disassembly and decladding method of spent PWR fuel, study on the OREOX process using simulated high burnup fuel, weldability of end cap weld, and development of fabrication equipment including the conceptual and detailed design of DUPIC equipment mainly for the powder preparation, pelletization and fuel element fabrication. A study on the material properties of DUPIC fuel and performance analysis method using irradiation of test fuel was also performed. (author). 91 refs., 274 tabs., 254 figs.

  13. Advances in clinical NK cell studies: Donor selection, manufacturing and quality control

    OpenAIRE

    Koehl, U.; Kalberer, C.; Spanholtz, J.; Lee, D. A.; Miller, J. S.; Cooley, S.; Lowdell, M.; Uharek, L.; Klingemann, H.; Curti, A.; Leung, W.; Alici, E.

    2015-01-01

    ABSTRACT Natural killer (NK) cells are increasingly used in clinical studies in order to treat patients with various malignancies. The following review summarizes platform lectures and 2013?2015 consortium meetings on manufacturing and clinical use of NK cells in Europe and United States. A broad overview of recent pre-clinical and clinical results in NK cell therapies is provided based on unstimulated, cytokine-activated, as well as genetically engineered NK cells using chimeric antigen rece...

  14. Dosimetric study for characterization of a postal system of quality control in brachytherapy

    International Nuclear Information System (INIS)

    Alves, Victor Gabriel Leandro; Queiroz Filho, Pedro Pacheco de; Santos, Denison de Souza; Begalli, Marcia

    2009-01-01

    This work presents a dosimetric study of a postal system, to be developed for measurements of brachytherapy. It was projected a PMMA phantom with orifices for insertion of the high dose 192 Ir source and the T L dosemeters. The system was characterized with using of Monte Carlo simulations, using the dosimetric magnitudes defined at the T G-43 of AAPM, as function of radial dose g(f)

  15. Effect of a web-based chronic disease management system on asthma control and health-related quality of life: study protocol for a randomized controlled trial.

    Science.gov (United States)

    Ahmed, Sara; Bartlett, Susan J; Ernst, Pierre; Paré, Guy; Kanter, Maria; Perreault, Robert; Grad, Roland; Taylor, Laurel; Tamblyn, Robyn

    2011-12-14

    Asthma is a prevalent and costly disease resulting in reduced quality of life for a large proportion of individuals. Effective patient self-management is critical for improving health outcomes. However, key aspects of self-management such as self-monitoring of behaviours and symptoms, coupled with regular feedback from the health care team, are rarely addressed or integrated into ongoing care. Health information technology (HIT) provides unique opportunities to facilitate this by providing a means for two way communication and exchange of information between the patient and care team, and access to their health information, presented in personalized ways that can alert them when there is a need for action. The objective of this study is to evaluate the acceptability and efficacy of using a web-based self-management system, My Asthma Portal (MAP), linked to a case-management system on asthma control, and asthma health-related quality of life. The trial is a parallel multi-centered 2-arm pilot randomized controlled trial. Participants are randomly assigned to one of two conditions: a) MAP and usual care; or b) usual care alone. Individuals will be included if they are between 18 and 70, have a confirmed asthma diagnosis, and their asthma is classified as not well controlled by their physician. Asthma control will be evaluated by calculating the amount of fast acting beta agonists recorded as dispensed in the provincial drug database, and asthma quality of life using the Mini Asthma Related Quality of Life Questionnaire. Power calculations indicated a needed total sample size of 80 subjects. Data are collected at baseline, 3, 6, and 9 months post randomization. Recruitment started in March 2010 and the inclusion of patients in the trial in June 2010. Self-management support from the care team is critical for improving chronic disease outcomes. Given the high volume of patients and time constraints during clinical visits, primary care physicians have limited time to

  16. A quality control study of the accuracy of patient positioning in irradiation of pelvic fields

    International Nuclear Information System (INIS)

    Creutzberg, Carien L.; Althof, Vincent G.M.; Hoog, Marjan de; Visser, Andries G.; Huizenga, Henk; Wijnmaalen, Arendjan; Levendag, Peter C.

    1996-01-01

    Purpose: Determining and improving the accuracy of patient positioning in pelvic fields. Methods and Materials: Small pelvic fields were studied in 16 patients treated for urological cancers using a three-field isocentric technique. Large pelvic fields were studied in 17 gynecological cancer patients treated with anterior and posterior (AP-PA) parallel opposed fields. Quantitative analysis of 645 megavolt images and comparison to 82 simulation images were carried out. Results: Small pelvic fields: for the position of the patient in the field, standard deviations of the difference between simulation (SIM) and treatment (MV) images were 3.4 mm in the lateral direction, 5.3 mm in the cranio-caudal direction, and 4.8 mm in the ventro-dorsal direction. Alterations in the positioning technique were made and tested. Large pelvic fields: differences between simulation and treatment images for the position of the patient in the field were 4 mm [1 standard deviation (SD)] in the lateral direction and 6.5 mm in the cranio-caudal direction. A systematic shift of the treatment field in the cranial direction had occurred in the majority of patients. A positioning technique using laser lines and marking of the caudal field border was shown to be more accurate. Conclusion: Studies of positioning accuracy in routine irradiation techniques are needed to obtain data for definition of the margins for each treatment site at each institution. Random variations should be kept at a minimum by monitoring and improving positioning techniques. Treatment verification by megavolt imaging or film should be used to detect and correct systematic variations early in the treatment series

  17. Exposure parameters in fluoroscopy equipment. Quality control

    International Nuclear Information System (INIS)

    Alonso, M.; Castaneda, M.J.; Matorras, P.; Diaz-Caneja, N.; Gutierrez, I.

    1992-01-01

    Within the quality control program in Diagnostic Radiology currently being undertaken at the 'Marques de Valdecilla' University Hospital, the corresponding specification and procedure prototypes for the control of conventional radioscopy equipment have been elaborated and applied. This paper presents the values proposed in the specifications and those obtained for the following radioscopy equipment parameters: reference kerma, and its reproducibility, kerma linearity, maximum kerma at the skin, and total filtration. The results obtained indicate that the equipment studied could comply with specified requirements if a Maintenance Program were to be implemented in coordination with the Quality Control Program. (author)

  18. A Randomized Control Trial of Cardiopulmonary Feedback Devices and Their Impact on Infant Chest Compression Quality: A Simulation Study.

    Science.gov (United States)

    Austin, Andrea L; Spalding, Carmen N; Landa, Katrina N; Myer, Brian R; Donald, Cure; Smith, Jason E; Platt, Gerald; King, Heather C

    2017-10-27

    In effort to improve chest compression quality among health care providers, numerous feedback devices have been developed. Few studies, however, have focused on the use of cardiopulmonary resuscitation feedback devices for infants and children. This study evaluated the quality of chest compressions with standard team-leader coaching, a metronome (MetroTimer by ONYX Apps), and visual feedback (SkillGuide Cardiopulmonary Feedback Device) during simulated infant cardiopulmonary resuscitation. Seventy voluntary health care providers who had recently completed Pediatric Advanced Life Support or Basic Life Support courses were randomized to perform simulated infant cardiopulmonary resuscitation into 1 of 3 groups: team-leader coaching alone (control), coaching plus metronome, or coaching plus SkillGuide for 2 minutes continuously. Rate, depth, and frequency of complete recoil during cardiopulmonary resuscitation were recorded by the Laerdal SimPad device for each participant. American Heart Association-approved compression techniques were randomized to either 2-finger or encircling thumbs. The metronome was associated with more ideal compression rate than visual feedback or coaching alone (104/min vs 112/min and 113/min; P = 0.003, 0.019). Visual feedback was associated with more ideal depth than auditory (41 mm vs 38.9; P = 0.03). There were no significant differences in complete recoil between groups. Secondary outcomes of compression technique revealed a difference of 1 mm. Subgroup analysis of male versus female showed no difference in mean number of compressions (221.76 vs 219.79; P = 0.72), mean compression depth (40.47 vs 39.25; P = 0.09), or rate of complete release (70.27% vs 64.96%; P = 0.54). In the adult literature, feedback devices often show an increase in quality of chest compressions. Although more studies are needed, this study did not demonstrate a clinically significant improvement in chest compressions with the addition of a metronome or visual

  19. Preparation, quality control and biodistribution studies of [61Cu]-oxinate for PET tumor imaging

    International Nuclear Information System (INIS)

    Jalilian, A.R.; Yousefnia, H.; Garousi, J.; Shafaii, K.; Bolourinovin, F.; Zolghadri, S.; Faghihi, R.

    2009-01-01

    Targeting apoptosis is an interesting issue in molecular imaging and various modalities have been presented. However, recent experiences in nuclear pharmacy demonstrated the application of small tracer molecules is more desired. This work was conducted for production of a radiolabeled copper complex, i.e. Cu-oxinate as a potential PET tracer for apoptosis imaging in oncology. Cu-61 was prepared by natural zinc target irradiation with 22 MeV protons (150 μA) via the nat Zn(p, xn) 61 Cu nuclear reaction with a yield of 3.33 mCi/μAh. In order to obtain the best labeling method, optimization reactions were performed for pH, temperature and concentration followed by solid phase extraction. Biodistribution of the tracer was studied in wild-type and fibrosarcoma bearing mice. Under the optimized conditions, radio-thin-layer chromatography (RTLC) and HPLC showed radiochemical purities of 99.99% and 97% respectively (with a minimum specific activity of 16 Ci/mM). Biodistribution of the tracer in fibrosarcoma bearing mice demonstrated a significant tumor uptake after 3 h. Tumor:blood and tumor:muscle ratios were 2.0 and 6.0 after 3 h, respectively. (authors)

  20. Cyclotron production, radiochemical separation and quality control of platinum radiotracers for toxicological studies

    International Nuclear Information System (INIS)

    Bonardi, M.; Birattari, C.; Groppi, F.; Arginelli, D.; Gini, L.; Gallorini, M.

    1998-01-01

    The increasing concentration of Pt, Pd and Rh in the environment is mainly due to the release of these elements from the catalytic converters of the motorvehicles. This situation makes it necessary to carry out metallotoxicological experiments on both cell cultures and laboratory animals, in order to assess their impact on living organisms after a Long Term and Low Level Exposure (LLE). Both nuclear reactions nat Ir(p,xn) and nat Os(α,xn) were investigated in the energy range up to 45 MeV for protons and 38 MeV for alpha-particles, in order to optimize the irradiation parameters for the production of 188,189,191 Pt. Several sets of thin- and thick-target excitation functions were determined experimentally by cyclotron irradiation at both Milano and Ispra cyclotrons. This paper reports the irradiation parameters studied and adopted and two radiochemical procedures for the separation of radio-Pt from an Os target, as well as from ruthenium, iridium and gold impurities. These procedures were used to obtain very high specific activity Pt radionuclides in No Carrier Added (NCA) form. Radionuclidic, radiochemical and chemical purity measurements were carried out by the use of several techniques like γ-spectrometry, ion-exchange radio-chromatography, atomic absorption spectrometry and neutron activation analysis. (author)

  1. Placement shift, sibling relationship quality, and child outcomes in foster care: a controlled study.

    Science.gov (United States)

    Linares, L Oriana; Li, MiMin; Shrout, Patrick E; Brody, Gene H; Pettit, Gregory S

    2007-12-01

    Sibling unity during family transitions is considered a protective factor for child behavior problems, but there is little empirical support for the widespread child protection policy of placing siblings together in foster care. In a prospective study of 156 maltreated children, siblings were classified in 1 of 3 placement groups: continuously together (n = 110), continuously apart (n = 22), and disrupted placement (siblings placed together were separated; n = 24). Changes in child adjustment as a function of sibling relationship and placement group were examined. Sibling positivity predicted lower child problems at follow-up (about 14 months later), while sibling negativity predicted higher child problems. Placement group did not affect child behavior problems at follow-up; however, compared to siblings in continuous placement (either together or apart), siblings in disrupted placement with high initial behavior problems were rated as having fewer problems at follow-up, while siblings in disrupted placement with low initial behavior problems were rated as having more problems at follow-up. These findings highlight the importance of considering relationships between siblings and the risk that one poses to another before early placement decisions are made.

  2. Quality control of X-ray films with blue spectral sensitivity: comparative study

    International Nuclear Information System (INIS)

    Carrasco, F.; Ruiz Cruces, R.; Sendra, F.; Diez de los rios, A.

    1994-01-01

    In this work, seven X-ray films with blue-ultraviolet spectral sensitivity have been studied by means of light sensitometry, x-ray sensitometry and spatial resolution test. Three screens of different composition and speed were use. Only the films HPX44 and RG showed a high base plus for (>0,30), the remaining films maintained their values between 0,21 and 0,26. When blue light sensitometry was substituted by green light sensitometry, base plus fog practically did not show variations and gradient and speed changed less than 4% and 10% respectively. Speed and Gradient must be calculated from the relation between exposition and optical density, avoiding parameters referred to type optical density of a given step of the wedge. Two films with high speed (RG and HPX 44), four films with medium speed (Curix RP2, NewRX, Cronex 4 and X-Omat S) and one film with low speed but high resolution (Cronex 7) have been found. The obtained results present useful comparative data to select and adequate film according to the characteristic of the x-ray examination and the available screens. (Author)

  3. PACS quality control and automatic problem notifier

    Science.gov (United States)

    Honeyman-Buck, Janice C.; Jones, Douglas; Frost, Meryll M.; Staab, Edward V.

    1997-05-01

    One side effect of installing a clinical PACS Is that users become dependent upon the technology and in some cases it can be very difficult to revert back to a film based system if components fail. The nature of system failures range from slow deterioration of function as seen in the loss of monitor luminance through sudden catastrophic loss of the entire PACS networks. This paper describes the quality control procedures in place at the University of Florida and the automatic notification system that alerts PACS personnel when a failure has happened or is anticipated. The goal is to recover from a failure with a minimum of downtime and no data loss. Routine quality control is practiced on all aspects of PACS, from acquisition, through network routing, through display, and including archiving. Whenever possible, the system components perform self and between platform checks for active processes, file system status, errors in log files, and system uptime. When an error is detected or a exception occurs, an automatic page is sent to a pager with a diagnostic code. Documentation on each code, trouble shooting procedures, and repairs are kept on an intranet server accessible only to people involved in maintaining the PACS. In addition to the automatic paging system for error conditions, acquisition is assured by an automatic fax report sent on a daily basis to all technologists acquiring PACS images to be used as a cross check that all studies are archived prior to being removed from the acquisition systems. Daily quality control is preformed to assure that studies can be moved from each acquisition and contrast adjustment. The results of selected quality control reports will be presented. The intranet documentation server will be described with the automatic pager system. Monitor quality control reports will be described and the cost of quality control will be quantified. As PACS is accepted as a clinical tool, the same standards of quality control must be established

  4. Quality control in nuclear medicine

    International Nuclear Information System (INIS)

    Kostadinova, I.

    2007-01-01

    Nuclear medicine comprises diagnosis and therapy of the diseases with radiopharmaceuticals. The ambition of all specialists in our country is their activity to reach European standards. In this connection, a Commission for external audit was formed to evaluate the quality of work in the centers of nuclear medicine. This Commission create a long-lasting programme based on the objective European criteria and the national standard of nuclear medicine, having in mind to increase quality of the work and the expert evaluation of activity in every center. The program comprises measures for quality control of instrumentation, radiopharmaceuticals, performed investigations, obtained results and the whole organization from the receiving of the isotopes to the results of the patients. The ambition is most of the centers to fulfill the requirements. As a conclusion it could be said that not only the quality of everyday nuclear medicine work is enough to increase the prestige of the specialty. It is also necessary we to have understanding expert and financial support from corresponding institutions, incl. Ministry of health for a delivery of a new, contemporary instrumentation with new possibilities. Thus it would be possible Bulgarian patients to reach the high technology apparatuses for an early functional diagnosis of the diseases and optimal treatment, which possibility have the patients from the developed countries. (author)

  5. Quality control programme for radiotherapy

    International Nuclear Information System (INIS)

    Campos de Araujo, A.M.; Viegas, C.C.B.; Viamonte, A.M.

    2002-01-01

    A 3 years pilot programme started in January 2000 with 33 philanthropic cancer institutions that provides medical services to 60% of the patients from the national social security system. Brazil has today 161 radiotherapy services (144 operating with megavoltage equipment). These 33 institutions are distributed over 19 Brazilian states. The aim of this programme is: To create conditions to allow the participants to apply the radiotherapy with quality and efficacy; To promote up dating courses for the physicians, physicists and technicians of these 33 Institutions. With the following objectives: To recommend dosimetric and radiological protection procedures in order to guarantee the tumor prescribed dose and safe working conditions; To help in establishing and implementing these procedures. The main activities are: local quality control evaluations, postal TLD audits in reference conditions, postal TLD audits in off axis conditions and training. The local quality control program has already evaluated 22 institutions with 43 machines (25 Co-60 and 18 linear accelerators). In these visits we perform dosimetric, electrical, mechanical and safety tests. As foreseen, we found more problems among the old Co-60 machines i.e., field flatness, size, symmetry and relative output factors; lasers positioning system alignment; optical distance indicator; radiation and light field coincidence; optical and mechanical distance indicators agreement, than among the linear accelerators i.e., field flatness and size; lasers positioning system alignment; tray interlocking and wedge filter factors

  6. Quality control of CT systems by automated monitoring of key performance indicators: a two-year study.

    Science.gov (United States)

    Nowik, Patrik; Bujila, Robert; Poludniowski, Gavin; Fransson, Annette

    2015-07-08

    The purpose of this study was to develop a method of performing routine periodical quality controls (QC) of CT systems by automatically analyzing key performance indicators (KPIs), obtainable from images of manufacturers' quality assurance (QA) phantoms. A KPI pertains to a measurable or determinable QC parameter that is influenced by other underlying fundamental QC parameters. The established KPIs are based on relationships between existing QC parameters used in the annual testing program of CT scanners at the Karolinska University Hospital in Stockholm, Sweden. The KPIs include positioning, image noise, uniformity, homogeneity, the CT number of water, and the CT number of air. An application (MonitorCT) was developed to automatically evaluate phantom images in terms of the established KPIs. The developed methodology has been used for two years in clinical routine, where CT technologists perform daily scans of the manufacturer's QA phantom and automatically send the images to MonitorCT for KPI evaluation. In the cases where results were out of tolerance, actions could be initiated in less than 10 min. 900 QC scans from two CT scanners have been collected and analyzed over the two-year period that MonitorCT has been active. Two types of errors have been registered in this period: a ring artifact was discovered with the image noise test, and a calibration error was detected multiple times with the CT number test. In both cases, results were outside the tolerances defined for MonitorCT, as well as by the vendor. Automated monitoring of KPIs is a powerful tool that can be used to supplement established QC methodologies. Medical physicists and other professionals concerned with the performance of a CT system will, using such methods, have access to comprehensive data on the current and historical (trend) status of the system such that swift actions can be taken in order to ensure the quality of the CT examinations, patient safety, and minimal disruption of service.

  7. Family Control and Earnings Quality

    Directory of Open Access Journals (Sweden)

    Carolina Bona Sánchez

    2007-06-01

    Full Text Available El trabajo analiza la relación entre el control familiar y la calidad de la información contable en un contexto en el que el tradicional conflicto de agencia entre directivos y accionistas se desplaza a la divergencia de intereses entre accionistas controladores y minoritarios. Los resultados alcanzados muestran que, en comparación con las no familiares, las empresas de naturaleza familiar divulgan unos resultados de mayor calidad, tanto en términos de menores ajustes por devengo discrecionales como de mayor capacidad de los componentes actuales del resultado para predecir los cash flows futuros. Además, el aumento en los derechos de voto en manos de la familia controladora incrementa la calidad de los resultados contables. La evidencia obtenida se muestra consistente con la presencia de un efecto reputación/vinculación a largo plazo asociado a la empresa familiar. Adicionalmente, el trabajo refleja que a medida que disminuye la divergencia entre los derechos de voto y de cash flow en manos de la familia controladora, aumenta la calidad de la información contable.PALABRAS CLAVE: derechos de voto, divergencia, empresa familiar, calidad delresultado, reputación, beneficios privados.This work examines the relationship between family control and earnings quality in a context where the salient agency problem shifts away from the classical divergence between managers and shareholders to conflicts between the controlling owner and minority shareholders. The results reveal that, compared to non-family firms, family firms reveal higher earnings quality in terms of both lower discretionary accruals and greater predictability of future cash flows. They also show a positive relationship between the level of voting rights held by the controlling family and earnings quality. The evidence is consistent with the presence of a reputation/long-term involvement effect associated with the family firm. Moreover, the work reflects that, as the divergence

  8. Physicians, radiologists, and quality control

    International Nuclear Information System (INIS)

    Payne, W.F.

    1973-01-01

    Factors involved in quality control in medical x-ray examinations to achieve the least possible exposure to the patient are discussed. It would be hoped that film quality will remain in the position of paramount importance that it must in order to achieve the greatest amount of diagnostic information on each radiographic examination. At the same time, it is hoped that this can be done by further reducing the exposure of the patient to ionizing radiation by the methods that have been discussed; namely, education of the physician, radiologist, and technologist, modern protective equipment and departmental construction, efficient collimation whether automatic or manual, calibration and output measurement of the radiographic and fluoroscopic units, ongoing programs of education within each department of radiographic facility, film badge monitoring, education of and cooperation with the nonradiologic physician, and hopefully, more intensive programs by the National and State Bureaus and Departments of Radiological Health in education and encouragement to the medical community. (U.S.)

  9. Quality control of pesticide products

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-07-15

    In light of an established need for more efficient analytical procedures, this publication, which documents the findings of an IAEA coordinated research project (CRP) on “Quality Control of Pesticide Products”, simplifies the existing protocol for pesticide analysis while simultaneously upholding existing standards of quality. This publication includes both a report on the development work done in the CRP and a training manual for use by pesticide analysis laboratories. Based on peer reviewed and internationally recognized methods published by the Association of Analytical Communities (AOAC) and the Collaborative International Pesticides Analytical Council (CIPAC), this report provides laboratories with versatile tools to enhance the analysis of pesticide chemicals and to extend the scope of available analytical repertoires. Adoption of the proposed analytical methodologies promises to reduce laboratories’ use of solvents and the time spent on reconfiguration and set-up of analytical equipment.

  10. Quality control of pesticide products

    International Nuclear Information System (INIS)

    2009-07-01

    In light of an established need for more efficient analytical procedures, this publication, which documents the findings of an IAEA coordinated research project (CRP) on “Quality Control of Pesticide Products”, simplifies the existing protocol for pesticide analysis while simultaneously upholding existing standards of quality. This publication includes both a report on the development work done in the CRP and a training manual for use by pesticide analysis laboratories. Based on peer reviewed and internationally recognized methods published by the Association of Analytical Communities (AOAC) and the Collaborative International Pesticides Analytical Council (CIPAC), this report provides laboratories with versatile tools to enhance the analysis of pesticide chemicals and to extend the scope of available analytical repertoires. Adoption of the proposed analytical methodologies promises to reduce laboratories’ use of solvents and the time spent on reconfiguration and set-up of analytical equipment

  11. Water quality control program in experimental circuits

    International Nuclear Information System (INIS)

    Cegalla, Miriam A.

    1996-01-01

    The Water Quality Control Program of the Experimental Circuits visualizes studying the water chemistry of the cooling in the primary and secondary circuits, monitoring the corrosion of the systems and studying the mechanism of the corrosion products transport in the systems. (author)

  12. Bootstrap Signal-to-Noise Confidence Intervals: An Objective Method for Subject Exclusion and Quality Control in ERP Studies

    Science.gov (United States)

    Parks, Nathan A.; Gannon, Matthew A.; Long, Stephanie M.; Young, Madeleine E.

    2016-01-01

    Analysis of event-related potential (ERP) data includes several steps to ensure that ERPs meet an appropriate level of signal quality. One such step, subject exclusion, rejects subject data if ERP waveforms fail to meet an appropriate level of signal quality. Subject exclusion is an important quality control step in the ERP analysis pipeline as it ensures that statistical inference is based only upon those subjects exhibiting clear evoked brain responses. This critical quality control step is most often performed simply through visual inspection of subject-level ERPs by investigators. Such an approach is qualitative, subjective, and susceptible to investigator bias, as there are no standards as to what constitutes an ERP of sufficient signal quality. Here, we describe a standardized and objective method for quantifying waveform quality in individual subjects and establishing criteria for subject exclusion. The approach uses bootstrap resampling of ERP waveforms (from a pool of all available trials) to compute a signal-to-noise ratio confidence interval (SNR-CI) for individual subject waveforms. The lower bound of this SNR-CI (SNRLB) yields an effective and objective measure of signal quality as it ensures that ERP waveforms statistically exceed a desired signal-to-noise criterion. SNRLB provides a quantifiable metric of individual subject ERP quality and eliminates the need for subjective evaluation of waveform quality by the investigator. We detail the SNR-CI methodology, establish the efficacy of employing this approach with Monte Carlo simulations, and demonstrate its utility in practice when applied to ERP datasets. PMID:26903849

  13. Associations of impaired sleep quality, insomnia, and sleepiness with epilepsy: A questionnaire-based case-control study.

    Science.gov (United States)

    Im, Hee-Jin; Park, Seong-Ho; Baek, Shin-Hye; Chu, Min Kyung; Yang, Kwang Ik; Kim, Won-Joo; Yun, Chang-Ho

    2016-04-01

    The purpose of this study was to document the frequency of sleep problems including poor sleep quality, excessive daytime sleepiness, and insomnia in subjects with epilepsy compared with healthy controls and to determine the factors associated with these sleep disturbances. We recruited 180 patients with epilepsy (age: 43.2 ± 15.6 years, men: 50.0%) and 2836 healthy subjects (age: 44.5 ± 15.0 years, men: 49.8%). Sleep and the anxiety/mood profiles were measured using the Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Insomnia Severity Index, Goldberg Anxiety Scale, and Patient Health Questionnaire-9 depression scale. Associations of sleep problems with epilepsy and other factors were tested by multiple logistic regression analysis, adjusted for age, gender, body mass index, alcohol intake, smoking, perceived sleep insufficiency, and habitual snoring. Sleep disturbances were more common in the group with epilepsy than in the controls (53.3% vs. 25.5%; pinsomnia were significantly associated with epilepsy (odds ratio [95% confidence interval]: 3.52 [2.45-5.05], 2.10 [1.41-3.12], 5.91 [3.43-10.16], respectively). Depressive mood, anxiety, and perceived sleep insufficiency contributed to the presence of sleep disturbances. In the group with epilepsy, seizure remission for the past year related to a lower frequency of insomnia, whereas age, sex, type of epilepsy, and number of antiepileptic drugs were not correlated with sleep problems. Epilepsy was significantly associated with the higher frequency of sleep disturbances, which supports the importance of screening sleep problems in patients with epilepsy and providing available intervention. Copyright © 2016 Elsevier Inc. All rights reserved.

  14. Quality of life in cancer survivors 5 years or more after total gastrectomy: a case-control study.

    Science.gov (United States)

    Lee, Seung Soo; Chung, Ho Young; Kwon, Oh Kyoung; Yu, Wansik

    2014-01-01

    This study investigated how total gastrectomy (TG), along with memories of cancer, affect the subjective wellness of survivors long after surgery. Rational approaches for effectively improving the quality of life (QoL) of these survivors were suggested. Between 2008 and 2013, QoL data of gastric cancer patients who underwent a curative TG, were obtained at 5-year postoperative follow-up visits (5-year survivors) and at visits beyond 5 years (long-term survivors). The control groups for these survivor groups were constructed from volunteers who visited our health-examination center for annual medical checkups. The Korean versions of the European Organization for Research and Treatment (EORTC) Quality of Life Questionnaire Core 30 (QLQ-C30) and the gastric cancer specific module, the EORTC QLQ-STO22, were used to assess QoL. Five-year survivors showed worse QoL compared to the control group in role functioning, social functioning, nausea/vomiting, appetite loss, financial difficulties, reflux, eating restrictions, taste, and body image, and better QoL in the emotional and cognitive functioning scales. In long-term survivors, deterioration in QoL were still apparent in financial difficulties, reflux, and eating restrictions, while QoL differences in the remaining scales had diminished. Surviving 5 years after TG does not result in living in a carefree state in terms of QoL. After 5 postoperative years, survivors still need extended care for deteriorated QoL indicators due to symptomatic, behavioral, and financial consequences of surgery. While relevant clinical and institutional approaches are required for corresponding declines in QoL, such efforts must extend beyond 5 postoperative years. Copyright © 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

  15. Water quality control system and water quality control method

    International Nuclear Information System (INIS)

    Itsumi, Sachio; Ichikawa, Nagayoshi; Uruma, Hiroshi; Yamada, Kazuya; Seki, Shuji

    1998-01-01

    In the water quality control system of the present invention, portions in contact with water comprise a metal material having a controlled content of iron or chromium, and the chromium content on the surface is increased than that of mother material in a state where compression stresses remain on the surface by mechanical polishing to form an uniform corrosion resistant coating film. In addition, equipments and/or pipelines to which a material controlling corrosion potential stably is applied on the surface are used. There are disposed a cleaning device made of a material less forming impurities, and detecting intrusion of impurities and removing them selectively depending on chemical species and/or a cleaning device for recovering drain from various kinds of equipment to feedwater, connecting a feedwater pipeline and a condensate pipeline and removing impurities and corrosion products. Then, water can be kept to neutral purified water, and the concentrations of oxygen and hydrogen in water are controlled within an optimum range to suppress occurrence of corrosion products. (N.H.)

  16. Standardization of D2 lymphadenectomy and surgical quality control (KLASS-02-QC): a prospective, observational, multicenter study [NCT01283893

    International Nuclear Information System (INIS)

    Kim, Hyoung-Il; Hur, Hoon; Kim, Youn Nam; Lee, Hyuk-Joon; Kim, Min-Chan; Han, Sang-Uk; Hyung, Woo Jin

    2014-01-01

    Extended systemic lymphadenectomy (D2) is standard procedure for surgical treatment of advanced gastric cancer (AGC) although less extensive lymphadenectomy (D1) can be applied to early gastric cancer. Complete D2 lymphadenectomy is the mandatory procedure for studies that evaluate surgical treatment results of AGC. However, the actual extent of D2 lymphadenectomy varies among surgeons because of a lacking consensus on the anatomical definition of each lymph node station. This study is aimed to develop a consensus for D2 lymphadenectomy and also to qualify surgeons that can perform both laparoscopic and open D2 gastrectomy. This (KLASS-02-QC) is a prospective, observational, multicenter study to qualify the surgeons that will participate in the KLASS-02-RCT, which is a prospective, randomized, clinical trial comparing laparoscopic and open gastrectomy for AGC. Surgeons and reviewers participating in the study will be required to complete a questionnaire detailing their professional experience and specific gastrectomy surgical background/training, and the gastrectomy metrics of their primary hospitals. All surgeons must submit three laparoscopic and three open D2 gastrectomy videos, respectively. Each video will be allocated to five peer reviewers; thus each surgeon’s operations will be assessed by a total of 30 reviews. Based on blinded assessment of unedited videos by experts’ review, a separate review evaluation committee will decide whether or not the evaluated surgeon will participate in the KLASS-02-RCT. The primary outcome measure is each surgeon’s proficiency, as assessed by the reviewers based on evaluation criteria for completeness of D2 lymphadenectomy. We believe that our study for standardization of D2 lymphadenectomy and surgical quality control (KLASS-02-QC) will guarantee successful implementation of the subsequent KLASS-02-RCT study. After making consensus on D2 lymphadenectomy, we developed evaluation criteria for completeness of D2

  17. Effect of Continuous Glucose Monitoring on Glycemic Control, Acute Admissions, and Quality of Life: A Real-World Study.

    Science.gov (United States)

    Charleer, Sara; Mathieu, Chantal; Nobels, Frank; De Block, Christophe; Radermecker, Regis P; Hermans, Michel P; Taes, Youri; Vercammen, Chris; T'Sjoen, Guy; Crenier, Laurent; Fieuws, Steffen; Keymeulen, Bart; Gillard, Pieter

    2018-03-01

    Randomized controlled trials evaluating real-time continuous glucose monitoring (RT-CGM) patients with type 1 diabetes (T1D) show improved glycemic control, but limited data are available on real-world use. To assess impact of RT-CGM in real-world settings on glycemic control, hospital admissions, work absenteeism, and quality of life (QOL). Prospective, observational, multicenter, cohort study. A total of 515 adults with T1D on continuous subcutaneous insulin infusion (CSII) therapy starting in the Belgian RT-CGM reimbursement program. Initiation of RT-CGM reimbursement. Hemoglobin A1c (HbA1c) evolution from baseline to 12 months. Between September 1, 2014, and December 31, 2016, 515 adults entered the reimbursement system. Over this period, 417 (81%) patients used RT-CGM for at least 12 months. Baseline HbA1c was 7.7 ± 0.9% (61 ± 9.8 mmol/mol) and decreased to 7.4 ± 0.8% (57 ± 8.7 mmol/mol) at 12 months (P < 0.0001). Subjects who started RT-CGM because of insufficient glycemic control showed stronger decrease in HbA1c at 4, 8, and 12 months compared with patients who started because of hypoglycemia or pregnancy. In the year preceding reimbursement, 16% of patients were hospitalized for severe hypoglycemia or ketoacidosis in contrast to 4% (P < 0.0005) the following year, with decrease in admission days from 54 to 18 per 100 patient years (P < 0.0005). In the same period, work absenteeism decreased and QOL improved significantly, with strong decline in fear of hypoglycemia. Sensor-augmented pump therapy in patients with T1D followed in specialized centers improves HbA1c, fear of hypoglycemia, and QOL, whereas work absenteeism and admissions for acute diabetes complications decreased.

  18. The Quality Initiative in Rectal Cancer (QIRC trial: study protocol of a cluster randomized controlled trial in surgery

    Directory of Open Access Journals (Sweden)

    Thabane Lehana

    2008-02-01

    Full Text Available Abstract Background Two unfortunate outcomes for patients treated surgically for rectal cancer are placement of a permanent colostomy and local tumor recurrence. Total mesorectal excision is a new technique for rectal cancer surgery that can lead to improved patient outcomes. We describe a cluster randomized controlled trial that is testing if the above patient outcomes can be improved through a knowledge translation strategy called the Quality Initiative in Rectal Cancer (QIRC strategy. The strategy is designed to optimize the use of total mesorectal excision techniques. Methods and Design Hospitals were randomized to the QIRC strategy (experimental group versus normal practice environment (control group. Participating hospitals, and the respective surgeon group operating in them, are from Ontario, Canada and have an annual procedure volume for major rectal cancer resections of 15 or greater. Patients were eligible if they underwent major rectal surgery for a diagnosis of primary rectal cancer. The surgeon-directed QIRC interventions included a workshop, use of opinion leaders, operative demonstrations, a post-operative questionnaire, and, audit and feedback. For an operative demonstration participating surgeons invited a study team surgeon to assist them with a case of rectal cancer surgery. The intent was to demonstrate total mesorectal excision techniques. Control arm surgeons received no intervention. Sample size calculations were two-sided, considered the clustering of data at the hospital level, and were driven by requirements for the outcome local recurrence. To detect an improvement in local recurrence from 20% to 8% with confidence we required 16 hospitals and 672 patients – 8 hospitals and 336 patients in each arm. Outcomes data are collected via chart review for at least 30 months after surgery. Analyses will use an intention-to-treat principle and will consider the clustering of data. Data collection will be complete by the end of

  19. 40 CFR 51.359 - Quality control.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Quality control. 51.359 Section 51.359....359 Quality control. Quality control measures shall insure that emission testing equipment is calibrated and maintained properly, and that inspection, calibration records, and control charts are...

  20. Professional medical writing support and the quality of randomised controlled trial reporting: a cross-sectional study.

    Science.gov (United States)

    Gattrell, William T; Hopewell, Sally; Young, Kate; Farrow, Paul; White, Richard; Wager, Elizabeth; Winchester, Christopher C

    2016-02-21

    Authors may choose to work with professional medical writers when writing up their research for publication. We examined the relationship between medical writing support and the quality and timeliness of reporting of the results of randomised controlled trials (RCTs). Cross-sectional study. Primary reports of RCTs published in BioMed Central journals from 2000 to 16 July 2014, subdivided into those with medical writing support (n=110) and those without medical writing support (n=123). Proportion of items that were completely reported from a predefined subset of the Consolidated Standards of Reporting Trials (CONSORT) checklist (12 items known to be commonly poorly reported), overall acceptance time (from manuscript submission to editorial acceptance) and quality of written English as assessed by peer reviewers. The effect of funding source and publication year was examined. The number of articles that completely reported at least 50% of the CONSORT items assessed was higher for those with declared medical writing support (39.1% (43/110 articles); 95% CI 29.9% to 48.9%) than for those without (21.1% (26/123 articles); 95% CI 14.3% to 29.4%). Articles with declared medical writing support were more likely than articles without such support to have acceptable written English (81.1% (43/53 articles); 95% CI 67.6% to 90.1% vs 47.9% (23/48 articles); 95% CI 33.5% to 62.7%). The median time of overall acceptance was longer for articles with declared medical writing support than for those without (167 days (IQR 114.5-231 days) vs 136 days (IQR 77-193 days)). In this sample of open-access journals, declared professional medical writing support was associated with more complete reporting of clinical trial results and higher quality of written English. Medical writing support may play an important role in raising the quality of clinical trial reporting. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go

  1. Quality control in paediatric nuclear medicine

    International Nuclear Information System (INIS)

    Fischer, S.; Hahn, K.

    1997-01-01

    Nuclear medicine examinations in children require a maximum in quality. This is true for the preparation of the child and parents, the imaging procedure, processing and documentation. It is necessary that quality control through all steps is performed regularly. The aim must be that the children receive a minimum radiation dose, while there needs to be a high quality in imaging and clinical information from the study. Furthermore the child should not be too much psychologically affected by the nuclear medicine examination. (orig.) [de

  2. Study of methodologies for quality control of 99Mo used in 99Mo/99mTc generators

    International Nuclear Information System (INIS)

    Said, Daphne de Souza

    2016-01-01

    99m Tc is the most used radionuclide in nuclear medicine. In Brazil, the 99 Mo/ 99m Tc generators are exclusively produced by Radiopharmacy Center at IPEN-CNEN/ SP, by importing 99 Mo from different suppliers. 99 Mo (t 1/2 = 66 h) is a fission product of 235 U and it can have radionuclidic impurities that are prejudicial for human health. For safe use of generators, it is necessary to perform the evaluation of 99 Mo by quality control tests in order to assess if 99 Mo complies with the specifications. The European Pharmacopoeia (EP) presents a monograph for evaluation of the quality of the [ 99 Mo] solution as sodium molybdate,that is used as raw material for 99 Mo/ 99m Tc generators production, including specification parameters (identification, radiochemical purity and radionuclidic purity), analysis methods and limits. However, it has been observed difficulties on the execution and implementation of these methods by the generators producers, with a few literature about this subject, probably due to complexity of the proposed methods. In this work, many quality control parameters of 99 Mo described in the EP monograph were evaluated. Separation methods for 99M o from its radionuclidic impurities by solid phase extraction (SPE) and TLC were studied. After SPE separation, the quantification of metals by ICP-OES to evaluate the percentage of retention of Mo and the percentage of recovery of Ru, Te and Sr using different types of cartridges were proposed, replacing radiotracers use. It was observed that the specific type of SPE cartridge recommended by the EP for separation of 99 Mo presented low recoveries for Ru, compared to other available anion exchange SPE cartridges. 99 Mo samples from different worldwide suppliers were analyzed. It was observed that quantification of 103 Ru in 99 Mo samples with decay time higher than 4 weeks is possible. An alternative method for separation of 131 I from 99 Mo showed promising results by TLC. The quantification of beta and

  3. A pilot study to evaluate the application of a generic protein standard panel for quality control of biomarker detection technologies

    Directory of Open Access Journals (Sweden)

    Valdivia Hernan J

    2011-08-01

    Full Text Available Abstract Background Protein biomarker studies are currently hampered by a lack of measurement standards to demonstrate quality, reliability and comparability across multiple assay platforms. This is especially pertinent for immunoassays where multiple formats for detecting target analytes are commonly used. Findings In this pilot study a generic panel of six non-human protein standards (50 - 10^7 pg/mL of varying abundance was prepared as a quality control (QC material. Simulated "normal" and "diseased" panels of proteins were prepared in pooled human plasma and incorporated into immunoassays using the Meso Scale Discovery® (MSD® platform to illustrate reliable detection of the component proteins. The protein panel was also evaluated as a spike-in material for a model immunoassay involving detection of ovarian cancer biomarkers within individual human plasma samples. Our selected platform could discriminate between two panels of the proteins exhibiting small differences in abundance. Across distinct experiments, all component proteins exhibited reproducible signal outputs in pooled human plasma. When individual donor samples were used, half the proteins produced signals independent of matrix effects. These proteins may serve as a generic indicator of platform reliability. Each of the remaining proteins exhibit differential signals across the distinct samples, indicative of sample matrix effects, with the three proteins following the same trend. This subset of proteins may be useful for characterising the degree of matrix effects associated with the sample which may impact on the reliability of quantifying target diagnostic biomarkers. Conclusions We have demonstrated the potential utility of this panel of standards to act as a generic QC tool for evaluating the reproducibility of the platform for protein biomarker detection independent of serum matrix effects.

  4. 2. Product quality control and assurance system

    International Nuclear Information System (INIS)

    1990-01-01

    Product quality control and assurance are dealt with in relation to reliability in nuclear power engineering. The topics treated include product quality control in nuclear power engineering, product quality assurance of nuclear power plant equipment, quality assurance programs, classification of selected nuclear power equipment, and standards relating to quality control and assurance and to nuclear power engineering. Particular attention is paid to Czechoslovak and CMEA standards. (P.A.). 2 figs., 1 tab., 12 refs

  5. Quality control of 11C-carfentanil

    International Nuclear Information System (INIS)

    Zhang Xiaojun; Zhang Jinming; Tian Jiahe; Xiang Xiaohui

    2013-01-01

    To study the quality control of 11 C-Carfentanil injection, physical, chemical and biological identification were used. The chemical and radiochemical purity of 11 C-Carfentanil Injection were detected by HPLC and Flower Count system; measured the quantity of product by LC-MS, specific activity was calculated later; The PTS was used to detect endotoxin, and other quality control methods were put up to guarantee the security of its clinical application. The produce appeared colorless and transparent, the radiochemical purity was more than 98%, content of the endotoxin was less than 5 EU/mL. The result showed that 11 C-Carfentanil injection had fulfilled pharmaceutical quality control request and could be applied safely to animal experiment and clinical diagnosis. (authors)

  6. Internal quality control: best practice.

    Science.gov (United States)

    Kinns, Helen; Pitkin, Sarah; Housley, David; Freedman, Danielle B

    2013-12-01

    There is a wide variation in laboratory practice with regard to implementation and review of internal quality control (IQC). A poor approach can lead to a spectrum of scenarios from validation of incorrect patient results to over investigation of falsely rejected analytical runs. This article will provide a practical approach for the routine clinical biochemistry laboratory to introduce an efficient quality control system that will optimise error detection and reduce the rate of false rejection. Each stage of the IQC system is considered, from selection of IQC material to selection of IQC rules, and finally the appropriate action to follow when a rejection signal has been obtained. The main objective of IQC is to ensure day-to-day consistency of an analytical process and thus help to determine whether patient results are reliable enough to be released. The required quality and assay performance varies between analytes as does the definition of a clinically significant error. Unfortunately many laboratories currently decide what is clinically significant at the troubleshooting stage. Assay-specific IQC systems will reduce the number of inappropriate sample-run rejections compared with the blanket use of one IQC rule. In practice, only three or four different IQC rules are required for the whole of the routine biochemistry repertoire as assays are assigned into groups based on performance. The tools to categorise performance and assign IQC rules based on that performance are presented. Although significant investment of time and education is required prior to implementation, laboratories have shown that such systems achieve considerable reductions in cost and labour.

  7. HPLC for quality control of polyimides

    Science.gov (United States)

    Young, P. R.; Sykes, G. F.

    1979-01-01

    High Pressure Liquid Chromatography (HPLC) as a quality control tool for polyimide resins and prepregs are presented. A data base to help establish accept/reject criteria for these materials was developed. This work is intended to supplement, not replace, standard quality control tests normally conducted on incoming resins and prepregs. To help achieve these objectives, the HPLC separation of LARC-160 polyimide precursor resin was characterized. Room temperature resin aging effects were studied. Graphite reinforced composites made from fresh and aged resin were fabricated and tested to determine if changes observed by HPLC were significant.

  8. Nurse case-manager vs multifaceted intervention to improve quality of osteoporosis care after wrist fracture: randomized controlled pilot study.

    Science.gov (United States)

    Majumdar, S R; Johnson, J A; Bellerose, D; McAlister, F A; Russell, A S; Hanley, D A; Garg, S; Lier, D A; Maksymowych, W P; Morrish, D W; Rowe, B H

    2011-01-01

    Few outpatients with fractures are treated for osteoporosis in the years following fracture. In a randomized pilot study, we found a nurse case-manager could double rates of osteoporosis testing and treatment compared with a proven efficacious quality improvement strategy directed at patients and physicians (57% vs 28% rates of appropriate care). Few patients with fractures are treated for osteoporosis. An intervention directed at wrist fracture patients (education) and physicians (guidelines, reminders) tripled osteoporosis treatment rates compared to controls (22% vs 7% within 6 months of fracture). More effective strategies are needed. We undertook a pilot study that compared a nurse case-manager to the multifaceted intervention using a randomized trial design. The case-manager counseled patients, arranged bone mineral density (BMD) tests, and prescribed treatments. We included controls from our first trial who remained untreated for osteoporosis 1-year post-fracture. Primary outcome was bisphosphonate treatment and secondary outcomes were BMD testing, appropriate care (BMD test-treatment if bone mass low), and costs. Forty six patients untreated 1-year after wrist fracture were randomized to case-manager (n = 21) or multifaceted intervention (n = 25). Median age was 60 years and 68% were female. Six months post-randomization, 9 (43%) case-managed patients were treated with bisphosphonates compared with 3 (12%) multifaceted intervention patients (relative risk [RR] 3.6, 95% confidence intervals [CI] 1.1-11.5, p = 0.019). Case-managed patients were more likely than multifaceted intervention patients to undergo BMD tests (81% vs 52%, RR 1.6, 95%CI 1.1-2.4, p = 0.042) and receive appropriate care (57% vs 28%, RR 2.0, 95%CI 1.0-4.2, p = 0.048). Case-management cost was $44 (CDN) per patient vs $12 for the multifaceted intervention. A nurse case-manager substantially increased rates of appropriate testing and treatment for osteoporosis in

  9. [Research progress on standardization study of NIR spectroscopy based method for quality control of traditional Chinese medicine].

    Science.gov (United States)

    Li, Wen-Long; Qu, Hai-Bin

    2016-10-01

    In recent years, the near infrared (NIR) spectroscopy has gained wide acceptance within the quantitative analysis of traditional Chinese medicine (TCM). However, the lack of technical standards is the bottleneck problem in this process. To address this issue, standardization study of the NIR spectroscopy based method for the quantitative analysis of TCM is needed, in which the specific characteristics of TCM should be given full considerations. The main research contents include:the scope definition for the application of NIR spectroscopy in the TCM quantitative analysis field, the selection criteria for the sample pretreatment and spectral acquisition conditions, the rules for the model optimization and evaluation, and the regulations for the model update and transfer. In this paper, some foreign studies in the agricultural areas are reviewed for reference. Different chemometrics methods reported in the literature are investigated and compared systematically. This research is important actual significance to the theoretical development of NIR spectroscopy analytical techniques, and will effectively promote the application of the technology in the TCM industry. Furthermore, it is beneficial to improve the technical level of TCM quality control, and can also be used as references to achieve similar purposes for other natural products. Copyright© by the Chinese Pharmaceutical Association.

  10. A Benchmark Study on Error Assessment and Quality Control of CCS Reads Derived from the PacBio RS.

    Science.gov (United States)

    Jiao, Xiaoli; Zheng, Xin; Ma, Liang; Kutty, Geetha; Gogineni, Emile; Sun, Qiang; Sherman, Brad T; Hu, Xiaojun; Jones, Kristine; Raley, Castle; Tran, Bao; Munroe, David J; Stephens, Robert; Liang, Dun; Imamichi, Tomozumi; Kovacs, Joseph A; Lempicki, Richard A; Huang, Da Wei

    2013-07-31

    PacBio RS, a newly emerging third-generation DNA sequencing platform, is based on a real-time, single-molecule, nano-nitch sequencing technology that can generate very long reads (up to 20-kb) in contrast to the shorter reads produced by the first and second generation sequencing technologies. As a new platform, it is important to assess the sequencing error rate, as well as the quality control (QC) parameters associated with the PacBio sequence data. In this study, a mixture of 10 prior known, closely related DNA amplicons were sequenced using the PacBio RS sequencing platform. After aligning Circular Consensus Sequence (CCS) reads derived from the above sequencing experiment to the known reference sequences, we found that the median error rate was 2.5% without read QC, and improved to 1.3% with an SVM based multi-parameter QC method. In addition, a De Novo assembly was used as a downstream application to evaluate the effects of different QC approaches. This benchmark study indicates that even though CCS reads are post error-corrected it is still necessary to perform appropriate QC on CCS reads in order to produce successful downstream bioinformatics analytical results.

  11. Validation of analytical method to quality control and the stability study of 0.025 % eyedrops Ketotiphen

    International Nuclear Information System (INIS)

    Troche Concepcion, Yenilen; Romero Diaz, Jacqueline Aylema; Garcia Penna, Caridad M

    2010-01-01

    The Ketotiphen eyedrop is prescribed to relief the signs and symptoms of allergic conjunctivitis due to its potent H 1a ntihistaminic effect showing some ability to inhibit the histamine release and other mediators in cases of mastocytosis. The aim of present paper was to develop and validate an analytical method for the high-performance liquid chromatography, to quality control and the stability studies of 0.025 % eyedrop Ketotiphen. Method was based on active principle separation by means of a Lichrosorb RP-18 (5 μm) (250 x 4 mm), with UV detection to 296 nm using a mobile phase including a non-gasified mixture of methanol:buffer-phosphate (75:25; pH 8.5) adding 1 mL of Isopropanol by each 1 000 mL of the previous mixture at a 1.2 mL/min flow velocity. The analytical method was linear, accurate, specific and exact during the study concentrations

  12. 14 CFR 21.139 - Quality control.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Quality control. 21.139 Section 21.139... PROCEDURES FOR PRODUCTS AND PARTS Production Certificates § 21.139 Quality control. The applicant must show that he has established and can maintain a quality control system for any product, for which he...

  13. Quality and reliability control on assemblies

    International Nuclear Information System (INIS)

    Mueller, H.

    1976-01-01

    Taking as an example electronic assemblies in printed circuit board engineering, quality control during manufacture is dealt with. After giving a survey of four phases of quality and reliability control, some specific methods of quality control are dealt with by means of a flowchart, and by some examples the necessity and the success of these measures are shown. (RW) [de

  14. 7 CFR 930.44 - Quality control.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Quality control. 930.44 Section 930.44 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Control § 930.44 Quality control. (a) Quality standards. The Board may establish, with the approval of the...

  15. 33 CFR 385.21 - Quality control.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Quality control. 385.21 Section... Processes § 385.21 Quality control. (a) The Corps of Engineers and the non-Federal sponsor shall prepare a quality control plan, in accordance with applicable Corps of Engineers regulations, for each product that...

  16. 7 CFR 981.42 - Quality control.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Quality control. 981.42 Section 981.42 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Quality Control § 981.42 Quality control. (a) Incoming. Except as provided in this...

  17. Quality control of CT systems by automated monitoring of key performance indicators: a two‐year study

    Science.gov (United States)

    Bujila, Robert; Poludniowski, Gavin; Fransson, Annette

    2015-01-01

    The purpose of this study was to develop a method of performing routine periodical quality controls (QC) of CT systems by automatically analyzing key performance indicators (KPIs), obtainable from images of manufacturers' quality assurance (QA) phantoms. A KPI pertains to a measurable or determinable QC parameter that is influenced by other underlying fundamental QC parameters. The established KPIs are based on relationships between existing QC parameters used in the annual testing program of CT scanners at the Karolinska University Hospital in Stockholm, Sweden. The KPIs include positioning, image noise, uniformity, homogeneity, the CT number of water, and the CT number of air. An application (MonitorCT) was developed to automatically evaluate phantom images in terms of the established KPIs. The developed methodology has been used for two years in clinical routine, where CT technologists perform daily scans of the manufacturer's QA phantom and automatically send the images to MonitorCT for KPI evaluation. In the cases where results were out of tolerance, actions could be initiated in less than 10 min. 900 QC scans from two CT scanners have been collected and analyzed over the two‐year period that MonitorCT has been active. Two types of errors have been registered in this period: a ring artifact was discovered with the image noise test, and a calibration error was detected multiple times with the CT number test. In both cases, results were outside the tolerances defined for MonitorCT, as well as by the vendor. Automated monitoring of KPIs is a powerful tool that can be used to supplement established QC methodologies. Medical physicists and other professionals concerned with the performance of a CT system will, using such methods, have access to comprehensive data on the current and historical (trend) status of the system such that swift actions can be taken in order to ensure the quality of the CT examinations, patient safety, and minimal disruption of service

  18. Association between product quality control and process quality control of bulk milk

    NARCIS (Netherlands)

    Velthuis, A.; Asseldonk, van M.A.P.M.

    2010-01-01

    Assessment of dairy-milk quality is based on product quality control (testing bulk-milk samples) and process quality control (auditing dairy farms). It is unknown whether process control improves product quality. To quantify possible association between product control and process control a

  19. Quality Control and Quality Assurance of Radiation Oncology

    International Nuclear Information System (INIS)

    Abaza, A.

    2016-01-01

    Radiotherapy (RT) has played important roles in cancer treatment for more than one century. The development of RT techniques allows high-dose irradiation to tumors while reducing the radiation doses delivered to surrounding normal tissues. However, RT is a complex process and involves understanding of the principles of medical physics, radiobiology, radiation safety, dosimetry, radiation treatment planning, simulation and interaction of radiation with other treatment modalities. Each step in the integrated process of RT needs quality control and quality assurance (QA) to prevent errors and to ensure that patients will receive the prescribed treatment correctly. The aim of this study is to help the radio therapists in identifying a system for QA that balances patient safety and quality with available resources. Recent advances in RT focus on the need for a systematic RT QA program that balances patient safety and quality with available resources. It is necessary to develop more formal error mitigation and process analysis methods, such as failure mode and effect analysis (FMEA), to focus available QA resources optimally on the process components. External audit programs are also effective. Additionally, Clinical trial QA has a significant role in enhancing the quality of care. The International Atomic Energy Agency (IAEA) has operated both an on-site and off-site postal dosimetry audit to improve practice and to assure the dose from RT equipment. Both postal dosimetry audit and clinical trial RTQA, especially for advanced technologies, in collaboration with global networks, will serve to enhance patient safety and quality of care

  20. Quality Assurance and Quality Control in TLD Measurement

    International Nuclear Information System (INIS)

    Bhuiyan, S.I.; Qronfla, M.M.; Abulfaraj, W.H.; Kinsara, A.A.; Taha, T.M.; Molla, N.I.; Elmohr, S.M.

    2008-01-01

    TLD technique characterized by high precision and reproducibility of dose measurement is presented by addressing pre-readout annealing, group sorting, dose evaluation, blind tests, internal dose quality audit and external quality control audits. Two hundred and forty TLD chips were annealed for 1 hour at 4000 degree C followed by 2 h at 1000 degree C. After exposure of 1 mGy from 90 Sr irradiator TLDs were subjected to pre-readout annealing at 1000 degree C, then readout, sorted into groups each with nearly equal sensitivity. Upon repeating the procedures, TLDs having response >3.5% from group mean were dropped to assuring group stability. Effect of pre-readout annealing has been studied. Series of repeated measurements were conducted to stabilize calibration procedures and DCF generation using SSDL level 137 Cs calibrator, dose master, ionization chambers. Performed internal dose quality audits, blind tests and validated by external QC tests with King Abdulaziz City of Science and Technology

  1. Disability and quality of life in community-dwelling elderly cancer survivors: Case-control study in the Korean population.

    Science.gov (United States)

    Lee, Myung Kyung

    2016-10-01

    Advanced age is a significant risk factor for cancer and functional disabilities increase with age. The purpose of this case-control study of Korean individuals was to determine the effect of cancer and cancer treatment on functional disability and quality of life (QOL). Thus, we compared community-dwelling elderly cancer patients (ECPs) with individuals from the general elderly population (GEP) who never had diagnoses of cancer. We selected 1776 ECP who were at least 65 years-old from the 2008 Korean Community Health Survey data and used propensity score matching to randomly select 1766 individuals from the GEP who closely resembled the ECPs. Functional disability was measured using the Instrumental Activities of Daily Living (IADL) scale, and QOL was measured by the EuroQol Group EQ-5D. ECPs were more dependent in preparation of food, doing laundry, and shopping (IADL scale), and in mobility and usual activities (EQ-5D). Although ECP had more problems with pain, discomfort, anxiety, and depression, they were more independent in self-care and handling of financial responsibilities. ECPs had multiple physical and psychological symptoms that adversely affected functional disability and QOL, but higher functional ability, such as self-care and handling of financial responsibilities. Promotion of self-care by ECPs is pivotal for effective management in community practice. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. [Quality in diabetes mellitus control in Primary Care Units in Mexico. A study of the perspectives of the patient's family].

    Science.gov (United States)

    Avalos García, María Isabel; López Ramón, Concepción; Morales García, Manuel Higinio; Priego Álvarez, Heberto Romeo; Garrido Pérez, Silvia María Guadalupe; Cargill Foster, Nelly Ruth

    2017-01-01

    To identify the perspectives of the patient's family in the quality of diabetes mellitus control. Qualitative methodology of exploratory design, oriented towards health services research, conducted in 2014 using non-probability sampling. Primary Care Units mainly situated in the state of Tabasco, Mexico. 42 family members were selected, who agreed to participate voluntarily in the study. Six focus groups were set up; interview guides and group dynamics were employed. The information was documented, saturated and categorised; the most representative discourses were used, and conclusions reached. The results show a highly critical position of the families as regards the patient, some of which appear justified, and others have a cultural, historical, and to some extent, an ignorance connotation. They have also commented on the health care and the role that patients and families can play, in both cases, also expressed critically. The family perspectives reveal what they think and feel about diabetes mellitus. It is important to note their lack of support and the content of their expressions due to lack of knowledge of the disease. Their discourses are critical, mythical, and with false beliefs of the fear of being future carriers of the disease. They feel sorry for the patient but they resist taking care of them, and do not want a life with diabetes. The family is the closest support for patients and an invaluable human resource for health services. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  3. Sleep Quality Effects Recovery After Total Knee Arthroplasty (TKA)--A Randomized, Double-Blind, Controlled Study.

    Science.gov (United States)

    Gong, Long; Wang, ZhenHu; Fan, Dong

    2015-11-01

    This study examined the effects of sleep quality on early recovery after total knee arthroplasty. A total of 148 patients were randomized 1:1 to receive either zolpidem or placebo for 2 weeks. VAS pain scores (rest, ambulation and night), range of motion (ROM), total amount of opioid analgesics and antiemetics taken, postoperative nausea and vomiting (PONV), sleep efficacy and satisfaction were recorded. It was found that patients taking zolpidem achieved greater improvement in quality of life and reported better satisfaction. Patients in the intervention group had lower pain score and took less antiemetics. Moreover, a significant correlation between sleep quality and ROM was detected. These results demonstrated that improved sleep quality is beneficial to patients' post-TKA recovery. Copyright © 2015. Published by Elsevier Inc.

  4. Pilot studies for the North American Soil Geochemical Landscapes Project - Site selection, sampling protocols, analytical methods, and quality control protocols

    Science.gov (United States)

    Smith, D.B.; Woodruff, L.G.; O'Leary, R. M.; Cannon, W.F.; Garrett, R.G.; Kilburn, J.E.; Goldhaber, M.B.

    2009-01-01

    In 2004, the US Geological Survey (USGS) and the Geological Survey of Canada sampled and chemically analyzed soils along two transects across Canada and the USA in preparation for a planned soil geochemical survey of North America. This effort was a pilot study to test and refine sampling protocols, analytical methods, quality control protocols, and field logistics for the continental survey. A total of 220 sample sites were selected at approximately 40-km intervals along the two transects. The ideal sampling protocol at each site called for a sample from a depth of 0-5 cm and a composite of each of the O, A, and C horizons. The Ca, Fe, K, Mg, Na, S, Ti, Ag, As, Ba, Be, Bi, Cd, Ce, Co, Cr, Cs, Cu, Ga, In, La, Li, Mn, Mo, Nb, Ni, P, Pb, Rb, Sb, Sc, Sn, Sr, Te, Th, Tl, U, V, W, Y, and Zn by inductively coupled plasma-mass spectrometry and inductively coupled plasma-atomic emission spectrometry following a near-total digestion in a mixture of HCl, HNO3, HClO4, and HF. Separate methods were used for Hg, Se, total C, and carbonate-C on this same size fraction. Only Ag, In, and Te had a large percentage of concentrations below the detection limit. Quality control (QC) of the analyses was monitored at three levels: the laboratory performing the analysis, the USGS QC officer, and the principal investigator for the study. This level of review resulted in an average of one QC sample for every 20 field samples, which proved to be minimally adequate for such a large-scale survey. Additional QC samples should be added to monitor within-batch quality to the extent that no more than 10 samples are analyzed between a QC sample. Only Cr (77%), Y (82%), and Sb (80%) fell outside the acceptable limits of accuracy (% recovery between 85 and 115%) because of likely residence in mineral phases resistant to the acid digestion. A separate sample of 0-5-cm material was collected at each site for determination of organic compounds. A subset of 73 of these samples was analyzed for a suite of

  5. Comparative study of the Quality Control of x-ray tubes and generators in hospital assistance and primary assistance in Galician autonomous community

    International Nuclear Information System (INIS)

    Pombar Camean, M.; Lobato Busto, R.

    1992-01-01

    The quality guarantee in Diagnostic Radiology is defined as the organized effort of surgical staff to guarantee sufficient quality images, which provide the correct diagnostic information, as cheaply as possible and with the least exposure to radiation for the patient. In this paper a comparative study about the quality control of x-ray tube and generators in hospital assistance and primary assistance is present. In the conclusions, it is confirmed that the antiquity and poor conservation of the primary attendance x-ray equipment, have influence on the studied constants and therefore, influence the doses received by the patients. (author)

  6. Quality control analysis at the hospital

    International Nuclear Information System (INIS)

    Kristensen, K.

    1979-01-01

    Quality control analysis is an integral part of quality assurance. In a system as with radiopharmaceuticals where part of the finishing of the product takes place at individual hospitals, the need for quality control analysis at the hospital can be discussed. Data are presented that stresses the importance of quality control by the manufacturer as a basis for limitation of such work at hospitals. A simplified programme is proposed

  7. Quality control guarantees the safety of radiotherapy

    International Nuclear Information System (INIS)

    Aaltonen, P.

    1994-01-01

    While radiotherapy equipment has seen some decisive improvements in the last few decades, the technology has also become more complicated. The advanced equipment produces increasingly good treatment results, but the condition of the equipment must be controlled efficiently so as to eliminate any defects that might jeopardise patient safety. The quality assurance measures that are taken to show that certain equipment functions as required are known as quality control. The advanced equipment and stricter requirements set for the precision of radiotherapy have meant that more attention must be paid to quality control. The present radiation legislation stipulates that radiotherapy equipment must undergo regular quality control. The implementation of the quality control is supervised by the Finnish Centre for Radiation and Nuclear Safety (STUK). Hospitals carry out quality control in accordance with a programme approved by STUK, and STUK inspectors periodically visit hospitals to check the results of quality control. (orig.)

  8. Radiopharmaceutical quality control-Pragmatic approach

    International Nuclear Information System (INIS)

    Barbier, Y.

    1994-01-01

    The quality control must be considered in a practical manner. The radiopharmaceuticals are drugs. They must satisfy the quality assurance control. These products are then conform to Pharmacopeia. But sometimes the user must control some data especially radiochemical purity and pH value. On all the administered solutions four controls are compulsory: radionuclide identity, administered radioactivity, organoleptic character and pH

  9. Effectiveness of multidisciplinary nutritional care on nutritional intake, nutritional status and quality of life in patients with hip fractures: a controlled prospective cohort study

    NARCIS (Netherlands)

    Hoekstra, Jellie C.; Goosen, Jon H. M.; de Wolf, G. Sander; Verheyen, Cees C. P. M.

    2011-01-01

    The purpose of this study was to determine the effectiveness of a multidisciplinary intervention program on nutritional intake and of nutritional intake on nutritional status and quality of life in older patients treated for a hip fracture. A controlled prospective cohort study included 66 patients

  10. Expert database system for quality control

    Science.gov (United States)

    Wang, Anne J.; Li, Zhi-Cheng

    1993-09-01

    There are more competitors today. Markets are not homogeneous they are fragmented into increasingly focused niches requiring greater flexibility in the product mix shorter manufacturing production runs and above allhigher quality. In this paper the author identified a real-time expert system as a way to improve plantwide quality management. The quality control expert database system (QCEDS) by integrating knowledge of experts in operations quality management and computer systems use all information relevant to quality managementfacts as well as rulesto determine if a product meets quality standards. Keywords: expert system quality control data base

  11. Symptomatic endometriosis of the posterior cul-de-sac is associated with impaired sleep quality, excessive daytime sleepiness and insomnia: a case-control study.

    Science.gov (United States)

    Leone Roberti Maggiore, Umberto; Bizzarri, Nicolò; Scala, Carolina; Tafi, Emanuela; Siesto, Gabriele; Alessandri, Franco; Ferrero, Simone

    2017-02-01

    To assess the impact of endometriosis of the posterior cul-de-sac on quality of sleep, average daytime sleepiness and insomnia. This age-matched case-control study was conducted in a tertiary referral centre for the diagnosis and treatment of endometriosis between May 2012 and December 2013. It included 145 women with endometriosis of the posterior cul-de-sac (cases; group E) and 145 patients referred to our Institution because of routine gynaecologic consultations (controls; group C). This study investigated whether sleep is impaired in patients with endometriosis of the posterior cul-de-sac. Sleep quality, daytime sleepiness and insomnia were assessed using the following self-administered questionnaires: the Pittsburgh Sleep Quality Index, the Epworth sleepiness scale and the Insomnia Severity Index, respectively. The primary objective of the study was to evaluate sleep quality in the two study groups. Secondary outcomes of the study were to assess average daytime sleepiness and insomnia in the two study groups. The prevalence of poor sleep quality was significantly higher in group E (64.8%) than in group C (15.1%; pinsomnia (29.0%) and moderate clinical insomnia (16.6%) significantly more frequently than patients in group C (24.4% and 5.0%; p=0.002). A substantial proportion of women with endometriosis of the posterior cul-de-sac experiences poor sleep quality, excessive daytime sleepiness and insomnia. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  12. Report on the quality control study NAT-6 for the determination of trace and minor elements in two moss samples

    International Nuclear Information System (INIS)

    Beise, A.; Smodis, A.

    2001-12-01

    A quality control study was organized on two moss materials. The materials were Pleuroziurn Schreberi species, a carpet forming moss which can be found throughout northern Europe. One material was collected from an unpolluted area and the other from a mining area in Scandinavia. 17 laboratories from 16 countries participated in the study, providing 26 sets of results. The following analytical methods were used: neutron activation analysis (NAA), inductive coupled plasma atomic emission spectrometry (ICP - AES), inductively coupled plasma mass spectrometry (ICP-MS), isotope-dilution thermal ionisation mass spectrometry IDTIMS) atomic absorption spectrometry (AAS), atomic fluorescence spectrometry (AFS) voltainetry V) and X-ray fluorescence spectrometry XRF). The results were evaluated following the standard IAEA procedures for (1) an interlaboratory comparison exercise and (2) a proficiency test using target values from the literature. For the moss sample M-1, 409 laboratory mean values for 47 elements were reported. More than 4 mean values were obtained for 28 measurands and these were statistically evaluated. Only 7 % 27 values) of the results were detected as outliers by the statistical data evaluation. There was good agreement for the results obtained by different methods for 21 elements (Al, Ba, Ca, Cd, Co, Cs, Cu, Fe, K, La, Mg, Mn, Na, Ni, Pb, Rb, Sb, Sc, Se, V, and Zn). Results for Br, Ce, Sn and Th were obtained only by NAA. Statistical evaluation of the data revealed satisfactory values for As, Hg and Cr. The results and statistical parameters are listed in the appendices I and II. The results were also evaluated as a proficiency test using target values from the literature. Precision and accuracy criteria were applied to 15 elements. 234 laboratory mean values were reported for these elements, 47 values (20%) did not pass the set proficiency test criteria. The individual laboratory results are listed in appendix IV. For the moss sample M-2, 347 laboratory

  13. Quality control of activity detectors

    International Nuclear Information System (INIS)

    Surma, M.J.

    2002-01-01

    The conditions decided on radiometric measurements quality as geometry, background, calibration etc. have been described. The testing methods for achieving high quality of radioactivity measurements using nuclear medicine instruments have been recommended

  14. Automatic exposure control in pediatric and adult multidetector CT examinations: A phantom study on dose reduction and image quality

    Energy Technology Data Exchange (ETDEWEB)

    Papadakis, Antonios E.; Perisinakis, Kostas; Damilakis, John [Department of Medical Physics, Faculty of Medicine, University of Crete, P.O. Box 1352, Iraklion 71110, Crete (Greece)

    2008-10-15

    The aim of this study was to assess the potential of a modern x,y,z modulation-based automatic exposure control system (AEC) for dose reduction in pediatric and adult multidetector CT (MDCT) imaging and evaluate the quality of the images obtained. Five physical anthropomorphic phantoms that simulate the average individual as neonate, 1-, 5-, 10-year old child, and adult were scanned with a MDCT scanner, equipped with a modern AEC system. Dose reduction (%DR) was calculated as the percentage difference of the mean modulated and the preset tube current-time product that is prescribed for standard head and body scan protocols. The effect of the tube potential and the orientation of the topogram acquisition on dose reduction were assessed. Image quality was evaluated on the basis of image noise and signal to noise ratio (SNR). The dose reduction values achieved in pediatric phantoms were remarkably lower than those achieved for the adult. The efficiency of the AEC is decreased at 80 kVp compared to higher tube potentials and for helical scans following an anterior posterior (AP-AEC) compared to a lateral (LAT-AEC) topogram acquisition. In AP-AEC scans, the dose reduction ranged between 4.7 and 34.7% for neonate, 15.4 and 30.9% for 1 year old, 3.1 and 26.7% for 5 years old, 1.2 and 58.7% for 10 years old, and 15.5 and 57.4% for adult. In LAT-AEC scans, the corresponding dose reduction ranged between 11.0 and 36.5%, 27.2 and 35.7%, 11.3 and 35.6%, 0.3 and 67.0%, and 15.0 and 61.7%, respectively. AP-AEC scans resulted in a 17.1% and 19.7% dose increase in the thorax of neonate and the pelvis of the 10-year old phantom, respectively. The variation in the measured noise among images obtained along the scanning z axis was lower in AEC activated compared to fixed milliamperes scans. However, image noise was significantly increased (P<.001) and SNR significantly decreased (P<.001) in most AEC activated compared to fixed milliamperes scans. In conclusion, AEC resulted in a (i

  15. 30 CFR 74.6 - Quality control.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality control. 74.6 Section 74.6 Mineral... of the CMDPSU will be maintained in production through adequate quality control procedures, MSHA and... DUST SAMPLING DEVICES Approval Requirements for Coal Mine Dust Personal Sampler Unit § 74.6 Quality...

  16. Employee quality, monitoring environment and internal control

    OpenAIRE

    Chunli Liu; Bin Lin; Wei Shu

    2017-01-01

    We investigate the effect of internal control employees (ICEs) on internal control quality. Using special survey data from Chinese listed firms, we find that ICE quality has a significant positive influence on internal control quality. We examine the effect of monitoring on this result and find that the effect is more pronounced for firms with strict monitoring environments, especially when the firms implement the Chinese internal control regulation system (CSOX), have higher institutional ow...

  17. The impact of laboratory characteristics on molecular detection of respiratory syncytial virus in a European multicentre quality control study

    NARCIS (Netherlands)

    Meerhoff, T. J.; MacKay, W. G.; Meijer, A.; Paget, W. J.; Niesters, H. G. M.; Kimpen, J. L. L.; Schellevis, F.

    2008-01-01

    The performance of nucleic acid amplification techniques for detecting respiratory syncytial virus (RSV) was evaluated in 25 laboratories across Europe by an external quality assessment study. In addition, factors related to the diagnostic performance of laboratories were explored. The results of

  18. Double disadvantage: A case control study on health-related quality of life in children with sickle cell disease.

    NARCIS (Netherlands)

    Hijmans, C.T.; Fijnvandraat, K.; Oosterlaan, J.; Heijboer, H.; Peters, M.; Grootenhuis, M.A.

    2010-01-01

    Background: Low health-related quality of life (HRQoL) of children with sickle cell disease (SCD) may be associated with consequences of the disease, or with the low socio-economic status (SES) of this patient population. The aim of this study was to investigate the HRQoL of children with SCD,

  19. Minimal requirements for quality controls in radiotherapy with external beams

    International Nuclear Information System (INIS)

    1999-01-01

    Physical dosimetric guidelines have been developed by the Italian National Institute of Health study group on quality assurance in radiotherapy to define protocols for quality controls in external beam radiotherapy. While the document does not determine strict rules or firm recommendations, it suggests minimal requirements for quality controls necessary to guarantee an adequate degree of accuracy in external beam radiotherapy [it

  20. Problems of quality assurance and quality control in diagnostic radiology

    International Nuclear Information System (INIS)

    Angerstein, W.

    1986-01-01

    Topical problems of quality assurance and quality control in diagnostic radiology are discussed and possible solutions are shown. Complex units are differentiated with reference to physicians, technicians, organization of labour, methods of examination and indication. Quality control of radiologic imaging systems should involve three stages: (1) simple tests carried out by radiologic technicians, (2) measurements by service technicians, (3) testing of products by the manufacturer and independent governmental or health service test agencies. (author)

  1. Double disadvantage: a case control study on health-related quality of life in children with sickle cell disease

    Directory of Open Access Journals (Sweden)

    Heijboer Harriët

    2010-10-01

    Full Text Available Abstract Background Low health-related quality of life (HRQoL of children with sickle cell disease (SCD may be associated with consequences of the disease, or with the low socio-economic status (SES of this patient population. The aim of this study was to investigate the HRQoL of children with SCD, controlling for SES by comparing them to healthy siblings (matched for age and gender, and to a Dutch norm population. Methods The HRQoL of 40 children with homozygous SCD and 36 healthy siblings was evaluated by the KIDSCREEN-52. This self-report questionnaire assesses ten domains of HRQoL. Differences between children with SCD and healthy siblings were analyzed using linear mixed models. One-sample t-tests were used to analyze differences with the Dutch norm population. Furthermore, the proportion of children with SCD with impaired HRQoL was evaluated. Results In general, the HRQoL of children with SCD appeared comparable to the HRQoL of healthy siblings, while children with SCD had worse HRQoL than the Dutch norm population on five domains (Physical Well-being, Moods & Emotions, Autonomy, Parent Relation, and Financial Resources. Healthy siblings had worse HRQoL than the Dutch norm population on three domains (Moods & Emotions, Parent Relation, and Financial Resources. More than one in three children with SCD and healthy siblings had impaired HRQoL on several domains. Conclusion These findings imply that reduced HRQoL in children with SCD is mainly related to the low SES of this patient population, with the exception of disease specific effects on the physical and autonomy domain. We conclude that children with SCD are especially vulnerable compared to other patient populations, and have special health care needs.

  2. On the Control of Solute Mass Fluxes and Concentrations Below Fields Irrigated With Low-Quality Water: A Numerical Study

    Science.gov (United States)

    Russo, David

    2017-11-01

    The main goal of this study was to test the capability of irrigation water-based and soil-based approaches to control nitrate and chloride mass fluxes and concentrations below the root zone of agricultural fields irrigated with treated waste water (TWW). Using numerical simulations of flow and transport in relatively a fine-textured, unsaturated, spatially heterogeneous, flow domain, scenarios examined include: (i) irrigating with TWW only (REF); (ii) irrigation water is substituted between TWW and desalinized water (ADW); (iii) soil includes a capillary barrier (CB) and irrigating with TWW only (CB + TWW); and (iv) combination of (ii) and a CB (CB + ADW). Considering groundwater quality protection, plausible goals are: (i) to minimize solute discharges leaving the root zone, and, (ii) to maximize the probability that solute concentrations leaving the root zone will not exceed a prescribed, critical value. Results of the analyses suggest that in the case of a seasonal crop (a corn field) subject to irrigations only, with respect to the first goal, the CB + TWW and CB + ADW scenarios provide similar, excellent results, better than the ADW scenario; with respect to the second goal, however, the CB + ADW scenario gave substantially better results than the CB + TWW scenario. In the case a multiyear, perennial crop (a citrus orchard), subject to a sequence of irrigation and rainfall periods, for both solutes, and, particularly, nitrate, with respect to the two goals, both the ADW and CB + ADW scenarios perform better than the CB + TWW scenario. As compared with the REF and CB + TWW scenarios, the ADW and CB + ADW scenarios substantially reduce nitrogen mass fluxes to the groundwater and to the atmosphere, and, essentially, did not reduce nitrogen mass fluxes to the trees. Similar results, even better, were demonstrated for a relatively coarse-textured, spatially heterogeneous soil.

  3. A waitlist control-group study of cognitive, mood, and quality of life outcome after posteroventral pallidotomy in Parkinson disease.

    Science.gov (United States)

    Carr, Jason A R; Honey, Christopher R; Sinden, Marci; Phillips, Anthony G; Martzke, Jeffrey S

    2003-07-01

    The aim of this study was to examine neuropsychological outcome from unilateral posteroventral pallidotomy (PVP) in Parkinson disease while controlling for confounding factors such as test practice and disease progression. Participants underwent baseline and 2-month follow-up assessments of cognition, quality of life, mood, and motor functioning. The surgery group (22 patients) underwent PVP (15 left, seven right) after baseline assessment. The waitlist group (14 patients) underwent PVP after follow up. At follow up, the left PVP group exhibited a decline on verbal measures of learning, fluency, working memory, and speeded color naming. The incidence of significant decline on these measures after left PVP ranged from 50 to 86%. The right PVP group did not exhibit a significant cognitive decline, but fluency did decline in 71% of patients who underwent right PVP. Participants who underwent PVP reported better bodily pain and social functioning at follow up than participants in the waitlist group. Improved bodily pain was evident for 62% of the surgery group, and social functioning improved for 19%. Surgery did not alter reported physical functioning or mood. Dyskinesia improved after surgery, but there were no improvements in "on-state" manual dexterity or handwriting. Most patients who underwent left PVP exhibited declines in learning, fluency, working memory, and speeded color naming. Accounting for retesting effects altered the magnitude of these declines by up to one quarter of a standard deviation, but did not increase the breadth of postsurgical neuropsychological decline beyond that typically reported in the literature. It was found that PVP improved dyskinesia, bodily pain, and social functioning, but did not lead to improvement on other objective and self-reported measures of motor functioning.

  4. A novel protocol for dispatcher assisted CPR improves CPR quality and motivation among rescuers-A randomized controlled simulation study.

    Science.gov (United States)

    Rasmussen, Stinne Eika; Nebsbjerg, Mette Amalie; Krogh, Lise Qvirin; Bjørnshave, Katrine; Krogh, Kristian; Povlsen, Jonas Agerlund; Riddervold, Ingunn Skogstad; Grøfte, Thorbjørn; Kirkegaard, Hans; Løfgren, Bo

    2017-01-01

    Emergency dispatchers use protocols to instruct bystanders in cardiopulmonary resuscitation (CPR). Studies changing one element in the dispatcher's protocol report improved CPR quality. Whether several changes interact is unknown and the effect of combining multiple changes previously reported to improve CPR quality into one protocol remains to be investigated. We hypothesize that a novel dispatch protocol, combining multiple beneficial elements improves CPR quality compared with a standard protocol. A novel dispatch protocol was designed including wording on chest compressions, using a metronome, regular encouragements and a 10-s rest each minute. In a simulated cardiac arrest scenario, laypersons were randomized to perform single-rescuer CPR guided with the novel or the standard protocol. a composite endpoint of time to first compression, hand position, compression depth and rate and hands-off time (maximum score: 22 points). Afterwards participants answered a questionnaire evaluating the dispatcher assistance. The novel protocol (n=61) improved CPR quality score compared with the standard protocol (n=64) (mean (SD): 18.6 (1.4)) points vs. 17.5 (1.7) points, pCPR. A novel bundle of care protocol improved CPR quality score and motivation among rescuers. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  5. How early studies on secreted and membrane protein quality control gave rise to the ER associated degradation (ERAD) pathway: the early history of ERAD.

    Science.gov (United States)

    Needham, Patrick G; Brodsky, Jeffrey L

    2013-11-01

    All newly synthesized proteins are subject to quality control check-points, which prevent aberrant polypeptides from harming the cell. For proteins that ultimately reside in the cytoplasm, components that also reside in the cytoplasm were known for many years to mediate quality control. Early biochemical and genetic data indicated that misfolded proteins were selected by molecular chaperones and then targeted to the proteasome (in eukaryotes) or to proteasome-like particles (in bacteria) for degradation. What was less clear was how secreted and integral membrane proteins, which in eukaryotes enter the endoplasmic reticulum (ER), were subject to quality control decisions. In this review, we highlight early studies that ultimately led to the discovery that secreted and integral membrane proteins also utilize several components that constitute the cytoplasmic quality control machinery. This component of the cellular quality control pathway is known as ER associated degradation, or ERAD. This article is part of a Special Issue entitled: Functional and structural diversity of endoplasmic reticulum. Copyright © 2013 Elsevier B.V. All rights reserved.

  6. Production, quality control and initial imaging studies of [82mRb]RbCl for PET studies

    International Nuclear Information System (INIS)

    Rowshanfarzad, P.; Jalilian, A.R.; Kiyomarsi, M.; Sabet, M.; Karimian, A.R.; Moradkhani, S.; Mirzaii, M.

    2006-01-01

    Rubidium-82m was prepared via 15.4 MeV proton irradiation of a krypton-82 gaseous target (30% enrichment). Washing the target chamber with hot water yielded a Rb-82m containing solution, which was further purified using short column chromatography in order to remove organic/inorganic impurities. The flowthrough was formulated in normal saline for injection. Radionuclide, radiochemical and chemical purity tests were performed prior to administration to rats for imaging (radiochemical yield: 95-97%, radiochemical purity > 97%). Preliminary dual-head coincidence studies were performed to determine the distribution of [ 82m Rb]Rb in normal rats. For biodistribution studies, Rb-81 was injected to rats and tracer accumulation in heart, GI and bladder was determined after sacrification in time intervals. A yield of 1.3 GBq at EOB, 235.7 MBq/μAh was obtained. (authors)

  7. Distributed sensor architecture for intelligent control that supports quality of control and quality of service.

    Science.gov (United States)

    Poza-Lujan, Jose-Luis; Posadas-Yagüe, Juan-Luis; Simó-Ten, José-Enrique; Simarro, Raúl; Benet, Ginés

    2015-02-25

    This paper is part of a study of intelligent architectures for distributed control and communications systems. The study focuses on optimizing control systems by evaluating the performance of middleware through quality of service (QoS) parameters and the optimization of control using Quality of Control (QoC) parameters. The main aim of this work is to study, design, develop, and evaluate a distributed control architecture based on the Data-Distribution Service for Real-Time Systems (DDS) communication standard as proposed by the Object Management Group (OMG). As a result of the study, an architecture called Frame-Sensor-Adapter to Control (FSACtrl) has been developed. FSACtrl provides a model to implement an intelligent distributed Event-Based Control (EBC) system with support to measure QoS and QoC parameters. The novelty consists of using, simultaneously, the measured QoS and QoC parameters to make decisions about the control action with a new method called Event Based Quality Integral Cycle. To validate the architecture, the first five Braitenberg vehicles have been implemented using the FSACtrl architecture. The experimental outcomes, demonstrate the convenience of using jointly QoS and QoC parameters in distributed control systems.

  8. Distributed Sensor Architecture for Intelligent Control that Supports Quality of Control and Quality of Service

    Directory of Open Access Journals (Sweden)

    Jose-Luis Poza-Lujan

    2015-02-01

    Full Text Available This paper is part of a study of intelligent architectures for distributed control and communications systems. The study focuses on optimizing control systems by evaluating the performance of middleware through quality of service (QoS parameters and the optimization of control using Quality of Control (QoC parameters. The main aim of this work is to study, design, develop, and evaluate a distributed control architecture based on the Data-Distribution Service for Real-Time Systems (DDS communication standard as proposed by the Object Management Group (OMG. As a result of the study, an architecture called Frame-Sensor-Adapter to Control (FSACtrl has been developed. FSACtrl provides a model to implement an intelligent distributed Event-Based Control (EBC system with support to measure QoS and QoC parameters. The novelty consists of using, simultaneously, the measured QoS and QoC parameters to make decisions about the control action with a new method called Event Based Quality Integral Cycle. To validate the architecture, the first five Braitenberg vehicles have been implemented using the FSACtrl architecture. The experimental outcomes, demonstrate the convenience of using jointly QoS and QoC parameters in distributed control systems.

  9. Purified water quality study

    International Nuclear Information System (INIS)

    Spinka, H.; Jackowski, P.

    2000-01-01

    Argonne National Laboratory (HEP) is examining the use of purified water for the detection medium in cosmic ray sensors. These sensors are to be deployed in a remote location in Argentina. The purpose of this study is to provide information and preliminary analysis of available water treatment options and associated costs. This information, along with the technical requirements of the sensors, will allow the project team to determine the required water quality to meet the overall project goals

  10. Quality control and the multicrystal counter

    International Nuclear Information System (INIS)

    Hart, G.C.; Davis, K.M.

    1983-01-01

    The reliability of multicrystal counters for use in counting large numbers of radioimmunoassay samples is studied. In particular, the dependencies of the outputs from the array of detectors, and hence their degree of matching, on the count rate and volume of the samples being counted are investigated. Quality control procedures are described to assist in the assurance of consistent performance of the counter in the clinical situation. (U.K.)

  11. The software quality control for gamma spectrometry

    International Nuclear Information System (INIS)

    Monte, L.

    1986-01-01

    One of major problems with wich the quality control program of an environmental measurements laboratory is confronted is the evaluation of the performances of software packages for the analysis of gamma-ray spectra. A program of tests for evaluating the performances of the software package (SPECTRAN-F, Canberra Inc.) used by our laboratory is being carried out. In this first paper the results of a preliminary study concerning the evaluation of the performance of the doublet analysis routine are presented

  12. Reliability of nucleic acid amplification methods for detection of Chlamydia trachomatis in urine: results of the first international collaborative quality control study among 96 laboratories

    NARCIS (Netherlands)

    R.P.A.J. Verkooyen (Roel); G.T. Noordhoek; P.E. Klapper; J. Reid; J. Schirm; G.M. Cleator; M. Ieven; G. Hoddevik

    2003-01-01

    textabstractThe first European Quality Control Concerted Action study was organized to assess the ability of laboratories to detect Chlamydia trachomatis in a panel of urine samples by nucleic acid amplification tests (NATs). The panel consisted of lyophilized urine samples,

  13. Title IV Quality Control Project, Stage II. Management Option II: Delivery System Quality Improvements.

    Science.gov (United States)

    Advanced Technology, Inc., Reston, VA.

    Stage Two of the Title IV Quality Control Project is an integrated study of quality in five related Federal financial aid programs for postsecondary students. Section 1 of the paper establishes a framework for defining quality improvements, in order to identify the types of changes that would tend to improve quality across all facets of the…

  14. Quality and Control of Water Vapor Winds

    Science.gov (United States)

    Jedlovec, Gary J.; Atkinson, Robert J.

    1996-01-01

    Water vapor imagery from the geostationary satellites such as GOES, Meteosat, and GMS provides synoptic views of dynamical events on a continual basis. Because the imagery represents a non-linear combination of mid- and upper-tropospheric thermodynamic parameters (three-dimensional variations in temperature and humidity), video loops of these image products provide enlightening views of regional flow fields, the movement of tropical and extratropical storm systems, the transfer of moisture between hemispheres and from the tropics to the mid- latitudes, and the dominance of high pressure systems over particular regions of the Earth. Despite the obvious larger scale features, the water vapor imagery contains significant image variability down to the single 8 km GOES pixel. These features can be quantitatively identified and tracked from one time to the next using various image processing techniques. Merrill et al. (1991), Hayden and Schmidt (1992), and Laurent (1993) have documented the operational procedures and capabilities of NOAA and ESOC to produce cloud and water vapor winds. These techniques employ standard correlation and template matching approaches to wind tracking and use qualitative and quantitative procedures to eliminate bad wind vectors from the wind data set. Techniques have also been developed to improve the quality of the operational winds though robust editing procedures (Hayden and Veldon 1991). These quality and control approaches have limitations, are often subjective, and constrain wind variability to be consistent with model derived wind fields. This paper describes research focused on the refinement of objective quality and control parameters for water vapor wind vector data sets. New quality and control measures are developed and employed to provide a more robust wind data set for climate analysis, data assimilation studies, as well as operational weather forecasting. The parameters are applicable to cloud-tracked winds as well with minor

  15. A study of retention characteristics and quality control of nutraceuticals containing resveratrol and polydatin using fused-core column chromatography.

    Science.gov (United States)

    Fibigr, Jakub; Šatínský, Dalibor; Solich, Petr

    2016-02-20

    A new high-performance liquid chromatography method using fused-core column for fast separation of resveratrol and polydatin has been developed and used for quality control of nutraceuticals with resveratrol and polydatin content. Retention characteristics (log k) were studied under different conditions on C-18, RP-Amide C-18, Phenyl-hexyl, Pentafluorophenyl (F5) and Cyano stationary phases for both compounds. The effect of the volume fraction of acetonitrile on a retention factors log k of resveratrol and polydatin were evaluated. The optimal separation conditions for resveratrol, polydatin and internal standard p-nitrophenol were found on the fused-core column Ascentis Express ES-Cyano (100×3.0mm), particle size 2.7μm, with mobile phase acetonitrile/water solution with 0.5% acetic acid pH 3 (20:80, v/v) at a flow rate of 1.0mL/min and at 60°C. The detection wavelength was set at 305nm. Under the optimal chromatographic conditions, good linearity with regression coefficients in the range (r=0.9992-0.9998; n=10) for both compounds was achieved. Commercial samples of nutraceuticals were extracted with methanol using ultrasound bath for 15min. A 5μL sample volume of the filtered solution was directly injected into the HPLC system. Accuracy of the method defined as a mean recovery was in the range 83.2-107.3% for both nutraceuticals. The intraday method precision was found satisfactory and relative standard deviations of sample analysis were in the range 0.8-4.7%. The developed method has shown high sample throughput during sample preparation process, modern separation approach, and short time (3min) of analysis. The results of study showed that the declared content of resveratrol and polydatin varied widely in different nutraceuticals according the producers (71.50-115.00% of declared content). Copyright © 2015 Elsevier B.V. All rights reserved.

  16. Shipping/Receiving and Quality Control

    Data.gov (United States)

    Federal Laboratory Consortium — Shipping receiving, quality control, large and precise inspection and CMM machines. Coordinate Measuring Machines, including "scanning" probes, optical comparators,...

  17. Quality control of static irradiation processing products

    International Nuclear Information System (INIS)

    Bao Jianzhong; Chen Xiulan; Cao Hong; Zhai Jianqing

    2002-01-01

    Based on the irradiation processing practice of the nuclear technique application laboratory of Yangzhou Institute of Agricultural Science, the quality control of irradiation processing products is discussed

  18. In-hospital airway management training for non-anesthesiologist EMS physicians: a descriptive quality control study.

    Science.gov (United States)

    Trimmel, Helmut; Beywinkler, Christoph; Hornung, Sonja; Kreutziger, Janett; Voelckel, Wolfgang G

    2017-04-26

    Pre-hospital airway management is a major challenge for emergency medical service (EMS) personnel. Despite convincing evidence that the rescuer's qualifications determine efficacy of tracheal intubation, in-hospital airway management training is not mandatory in Austria, and often neglected. Thus we sought to prove that airway management competence of EMS physicians can be established and maintained by a tailored training program. In this descriptive quality control study we retrospectively evaluated all in- and pre-hospital airway cases managed by EMS physicians who underwent a structured in-hospital training program in anesthesia at General Hospital Wiener Neustadt. Data was obtained from electronic anesthesia and EMS documentation systems. From 2006 to 2016, 32 EMS physicians with 3-year post-graduate education, but without any prior experience in anesthesia were trained. Airway management proficiency was imparted in three steps: initial training, followed by an ongoing practice schedule in the operating room (OR). Median and interquartile range of number of in-hospital tracheal intubations (TIs) vs. use of supra-glottic airway devices (SGA) were 33.5 (27.5-42.5) vs. 19.0 (15.0-27.0) during initial training; 62.0 (41.8-86.5) vs. 33.5 (18.0-54.5) during the first, and 64.0 (34.5-93.8) vs. 27 (12.5-56.0) during the second year. Pre-hospitaly, every physician performed 9.0 (5.0-14.8) TIs vs. 0.0 (0.0-0.0) SGA cases during the first, and 9.0 (7.0-13.8) TIs vs. 0.0 (0.0-0.3) SGA during the second year. Use of an SGA was mandatory when TI failed after the second attempt, thus accounting for a total of 33 cases. In 8 cases, both TI and SGA failed, but bag mask ventilation was successfully performed. No critical events related to airway management were noted and overall success rate for TI with a max of 2 attempts was 95.3%. Number of TIs per EMS physician is low in the pre-hospital setting. A training concept that assures an additional 60+ TIs per year appears to

  19. Quality control within the multicentre perfusion CT study of primary colorectal cancer (PROSPeCT): results of an iodine density phantom study

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, Maria; Honey, Ian [Trust, Medical Physics Department, Guy' s and St. Thomas' NHS Foundation, London (United Kingdom); Goh, Vicky [King' s College London, St Thomas' Hospital, Division of Imaging Sciences and Biomedical Engineering, London (United Kingdom); Beggs, Shaun [Bradford Teaching Hospitals NHS Foundation Trust, Radiation Physics Services, Bradford (United Kingdom); Bridges, Andrew; Wayte, Sarah [Radiology Physics University Hospitals Coventry and Warwickshire NHS Trust, Coventry (United Kingdom); Clewer, Philip [Medical Physics Department, University Hospital Southampton NHS Foundation Trust, Southampton (United Kingdom); Davis, Anne [Portsmouth Hospitals NHS Trust, Medical Physics Department, Portsmouth (United Kingdom); Foy, Trevelyan [Royal Cornwall Hospital NHS Trust, Medical Physics Department, Truro (United Kingdom); Fuller, Karen [Sheffield Teaching Hospitals NHS Foundation Trust, Medical Physics Department, Sheffield (United Kingdom); George, Jennifer [University Hospital of North Staffordshire NHS Trust, Medical Physics Department, Stoke-on-Trent (United Kingdom); Higginson, Antony [Portsmouth Hospitals NHS Trust, Department of Radiology, Portsmouth (United Kingdom); Iball, Gareth [Leeds Teaching Hospitals NHS Trust, Department of Medical Physics and Engineering, Leeds (United Kingdom); Mutch, Steve [Oxford University Hospitals NHS Trust, Radiation Physics and Protection Department, Oxford (United Kingdom); Neil, Shellagh; Sutton, David [NHS Tayside, Medical Physics Department, Dundee, Scotland (United Kingdom); Rivett, Cat [Plymouth Hospitals NHS Trust, Clinical and Radiation Physics, Plymouth (United Kingdom); Slater, Andrew [Oxford University Hospitals NHS Trust, Department of Radiology, Oxford (United Kingdom); Weir, Nick [Queen' s Medical Research Institute, Clinical Research Imaging Centre, Edinburgh, Scotland (United Kingdom); Collaboration: on behalf of the PROSPeCT Investigators

    2014-09-15

    To assess the cross-centre consistency of iodine enhancement, contrast-to-noise ratio and radiation dose in a multicentre perfusion CT trial of colorectal cancer. A cylindrical water phantom containing different iodine inserts was examined on seven CT models in 13 hospitals. The relationship between CT number (Hounsfield units, HU) and iodine concentration (milligrams per millilitre) was established and contrast-to-noise ratios (CNRs) calculated. Radiation doses (CTDI{sub vol}, DLP) were compared across all sites. There was a linear relationship between CT number and iodine density. Iodine enhancement varied by a factor of at most 1.10, and image noise by at most 1.5 across the study sites. At an iodine concentration of 1 mg ml{sup -1} and 100 kV, CNRs ranged from 3.6 to 4.8 in the 220-mm phantom and from 1.4 to 1.9 in the 300-mm phantom. Doses varied by a factor of at most 2.4, but remained within study dose constraints. Iterative reconstruction algorithms did not alter iodine enhancement but resulted in reduced image noise by a factor of at most 2.2, allowing a potential dose decrease of at most 80 % compared to filtered back projection (FBP). Quality control of CT performance across centres indicates that CNR values remain relatively consistent across all sites, giving acceptable image quality within the agreed dose constraints. (orig.)

  20. Quality control within the multicentre perfusion CT study of primary colorectal cancer (PROSPeCT): results of an iodine density phantom study

    International Nuclear Information System (INIS)

    Lewis, Maria; Honey, Ian; Goh, Vicky; Beggs, Shaun; Bridges, Andrew; Wayte, Sarah; Clewer, Philip; Davis, Anne; Foy, Trevelyan; Fuller, Karen; George, Jennifer; Higginson, Antony; Iball, Gareth; Mutch, Steve; Neil, Shellagh; Sutton, David; Rivett, Cat; Slater, Andrew; Weir, Nick

    2014-01-01

    To assess the cross-centre consistency of iodine enhancement, contrast-to-noise ratio and radiation dose in a multicentre perfusion CT trial of colorectal cancer. A cylindrical water phantom containing different iodine inserts was examined on seven CT models in 13 hospitals. The relationship between CT number (Hounsfield units, HU) and iodine concentration (milligrams per millilitre) was established and contrast-to-noise ratios (CNRs) calculated. Radiation doses (CTDI vol , DLP) were compared across all sites. There was a linear relationship between CT number and iodine density. Iodine enhancement varied by a factor of at most 1.10, and image noise by at most 1.5 across the study sites. At an iodine concentration of 1 mg ml -1 and 100 kV, CNRs ranged from 3.6 to 4.8 in the 220-mm phantom and from 1.4 to 1.9 in the 300-mm phantom. Doses varied by a factor of at most 2.4, but remained within study dose constraints. Iterative reconstruction algorithms did not alter iodine enhancement but resulted in reduced image noise by a factor of at most 2.2, allowing a potential dose decrease of at most 80 % compared to filtered back projection (FBP). Quality control of CT performance across centres indicates that CNR values remain relatively consistent across all sites, giving acceptable image quality within the agreed dose constraints. (orig.)

  1. Quality Control in Production Processes

    Directory of Open Access Journals (Sweden)

    Prístavka Miroslav

    2016-09-01

    Full Text Available The tools for quality management are used for quality improvement throughout the whole Europe and developed countries. Simple statistics are considered one of the most basic methods. The goal was to apply the simple statistical methods to practice and to solve problems by using them. Selected methods are used for processing the list of internal discrepancies within the organization, and for identification of the root cause of the problem and its appropriate solution. Seven basic quality tools are simple graphical tools, but very effective in solving problems related to quality. They are called essential because they are suitable for people with at least basic knowledge in statistics; therefore, they can be used to solve the vast majority of problems.

  2. Quality control of mammographic systems

    International Nuclear Information System (INIS)

    Espana Lopez, M. L.

    2001-01-01

    High quality in mammography is a difficult objective to achieve, that is the reason for what efforts are made in order to improve equipment, to offer good combinations screen-film, and professional staff dedicated to this technique [es

  3. Quality control education in the community college

    Science.gov (United States)

    Greene, J. Griffen; Wilson, Steve

    1966-01-01

    This paper describes the Quality Control Program at Daytona Beach Junior College, including course descriptions. The program in quality control required communication between the college and the American Society for Quality Control (ASQC). The college has machinery established for certification of the learning process, and the society has the source of teachers who are competent in the technical field and who are the employers of the educational products. The associate degree for quality control does not have a fixed program, which can serve all needs, any more than all engineering degrees have identical programs. The main ideas which would be common to all quality control programs are the concept of economic control of a repetitive process and the concept of developing individual potentialities into individuals who are needed and productive.

  4. Effects of occupational therapy on quality of life of patients with metastatic prostate cancer. A randomized controlled study.

    Science.gov (United States)

    Huri, Meral; Huri, Emre; Kayihan, Hulya; Altuntas, Onur

    2015-08-01

    To evaluate the efficiency of occupational therapy relative to a home program in improving quality of life (QoL) among men who were treated for metastatic prostate cancer (MPC). Fifty-five men were assigned randomly to either the 12-week cognitive behavioral therapy based occupational therapy (OT-CBSM) intervention (treatment group) or a home program (control group) between March 2012 and August 2014 in the Department of Occupational Therapy, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey. The Canadian Occupational Performance Measure (COPM) was used to measure the occupational performance and identify difficulties in daily living activities. The QoL and symptom status were measured by The European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire C30 and its Prostate Cancer Module. A 12-week OT-CBSM intervention including client-centered training of daily living activities, recreational group activities, and cognitive behavioral stress management intervention were applied. The COPM performance and satisfaction scores, which indicate occupational participation and QoL increased statistically in the treatment group in relation to men who were included in the home-program (p less than or equal to 0.05). A 12-week OT-CBSM intervention was effective in improving QoL in men treated for MPC, and these changes were associated significantly with occupational performance.

  5. Related regulation of quality control of industrial products

    International Nuclear Information System (INIS)

    1983-04-01

    This book introduce related regulation of quality control of industrial products, which includes regulations of industrial products quality control, enforcement ordinance of industrial products quality control, enforcement regulation of quality control of industrial products, designated items with industrial production quality indication, industrial production quality test, and industrial production quality test organization and management tips of factory quality by grade.

  6. Quality control of nuclear medicine instrumentation

    International Nuclear Information System (INIS)

    Mould, R.F.

    1983-09-01

    The proceedings of a conference held by the Hospital Physicists' Association in London 1983 on the quality control of nuclear medicine instrumentation are presented. Section I deals with the performance of the Anger gamma camera including assessment during manufacture, acceptance testing, routine testing and long-term assessment of results. Section II covers interfaces, computers, the quality control problems of emission tomography and the quality of software. Section III deals with radionuclide measurement and impurity assessment and Section IV the presentation of images and the control of image quality. (U.K.)

  7. Quality control of recycled asphaltic concrete : final report.

    Science.gov (United States)

    1982-07-01

    This study examined the variations found in recycled asphaltic concrete mix based upon plant quality control data and verification testing. The data was collected from four recycled hot-mix projects constructed in 1981. All plant control and acceptan...

  8. Developing methods of controlling quality costs

    OpenAIRE

    Gorbunova A. V.; Maximova O. N.; Ekova V. A.

    2017-01-01

    The article examines issues of managing quality costs, problems of applying economic methods of quality control, implementation of progressive methods of quality costs management in enterprises with the view of improving the efficiency of their evaluation and analysis. With the aim of increasing the effectiveness of the cost management mechanism, authors introduce controlling as a tool of deviation analysis from the standpoint of the process approach. A list of processes and corresponding eva...

  9. The Influence of Parental Control and Parent-Child Relational Qualities on Adolescent Internet Addiction: A 3-Year Longitudinal Study in Hong Kong.

    Science.gov (United States)

    Shek, Daniel T L; Zhu, Xiaoqin; Ma, Cecilia M S

    2018-01-01

    This study investigated how parental behavioral control, parental psychological control, and parent-child relational qualities predicted the initial level and rate of change in adolescent internet addiction (IA) across the junior high school years. The study also investigated the concurrent and longitudinal effects of different parenting factors on adolescent IA. Starting from the 2009/2010 academic year, 3,328 Grade 7 students ( M age = 12.59 ± 0.74 years) from 28 randomly selected secondary schools in Hong Kong responded on a yearly basis to a questionnaire measuring multiple constructs including socio-demographic characteristics, perceived parenting characteristics, and IA. Individual growth curve (IGC) analyses showed that adolescent IA slightly decreased during junior high school years. While behavioral control of both parents was negatively related to the initial level of adolescent IA, only paternal behavioral control showed a significant positive relationship with the rate of linear change in IA, suggesting that higher paternal behavioral control predicted a slower decrease in IA. In addition, fathers' and mothers' psychological control was positively associated with the initial level of adolescent IA, but increase in maternal psychological control predicted a faster drop in IA. Finally, parent-child relational qualities negatively and positively predicted the initial level and the rate of change in IA, respectively. When all parenting factors were considered simultaneously, multiple regression analyses revealed that paternal behavioral control and psychological control as well as maternal psychological control and mother-child relational quality were significant concurrent predictors of adolescent IA at Wave 2 and Wave 3. Regarding the longitudinal predicting effects, paternal psychological control and mother-child relational quality at Wave 1 were the two most robust predictors of later adolescent IA at Wave 2 and Wave 3. The above findings underscore

  10. The Influence of Parental Control and Parent-Child Relational Qualities on Adolescent Internet Addiction: A 3-Year Longitudinal Study in Hong Kong

    Directory of Open Access Journals (Sweden)

    Daniel T. L. Shek

    2018-05-01

    Full Text Available This study investigated how parental behavioral control, parental psychological control, and parent-child relational qualities predicted the initial level and rate of change in adolescent internet addiction (IA across the junior high school years. The study also investigated the concurrent and longitudinal effects of different parenting factors on adolescent IA. Starting from the 2009/2010 academic year, 3,328 Grade 7 students (Mage = 12.59 ± 0.74 years from 28 randomly selected secondary schools in Hong Kong responded on a yearly basis to a questionnaire measuring multiple constructs including socio-demographic characteristics, perceived parenting characteristics, and IA. Individual growth curve (IGC analyses showed that adolescent IA slightly decreased during junior high school years. While behavioral control of both parents was negatively related to the initial level of adolescent IA, only paternal behavioral control showed a significant positive relationship with the rate of linear change in IA, suggesting that higher paternal behavioral control predicted a slower decrease in IA. In addition, fathers' and mothers' psychological control was positively associated with the initial level of adolescent IA, but increase in maternal psychological control predicted a faster drop in IA. Finally, parent-child relational qualities negatively and positively predicted the initial level and the rate of change in IA, respectively. When all parenting factors were considered simultaneously, multiple regression analyses revealed that paternal behavioral control and psychological control as well as maternal psychological control and mother-child relational quality were significant concurrent predictors of adolescent IA at Wave 2 and Wave 3. Regarding the longitudinal predicting effects, paternal psychological control and mother-child relational quality at Wave 1 were the two most robust predictors of later adolescent IA at Wave 2 and Wave 3. The above

  11. Team care to cure adolescents with braces (avoiding low quality of life, pain and bad compliance): a case–control retrospective study. 2011 SOSORT Award winner

    OpenAIRE

    Tavernaro, Marta; Pellegrini, Anna; Tessadri, Fabrizio; Zaina, Fabio; Zonta, Andrea; Negrini, Stefano

    2012-01-01

    Abstract Background Bracing could be efficacious, given good compliance and quality of braces. Recently the SOSORT Brace Treatment Management Guidelines (SBTMG) have highlighted the perceived importance of the professional teams surrounding braced patients. Purpose To verify the impact of a complete rehabilitation team in the adolescent patient with bracing. Materials and methods Design. Initial cross-sectional study, followed by a retrospective case–control study. Population: Thirty-eight pa...

  12. Fuel manufacture and quality control

    International Nuclear Information System (INIS)

    Roepenack, H.; Raab, K.

    1975-01-01

    The different steps in fuel and fuel element manufacturing from the conversion of UF 6 to UO 2 to the assembling of the whole fuel element are shortly described. Each of this fabrication steps must satisfy well-defined quality criteria which are checked in certain analyses or tests. (RB) [de

  13. Analytic and systematic study of ammonium in water and sewage quality control; Estudio analitico y sistematico del sensor de amonio en el control de calidad de aguas residuales

    Energy Technology Data Exchange (ETDEWEB)

    Salamanca Grosso, G. [Instituo de Ciencias Universidad del Tolima, Tolima, Colombia (Colombia); Castro Sanchez, N. [Facultad de Ciencias. Universidad del Valle. Cali Valle. colombia (Colombia); Perez Figueredo, C.R. [Universidad Pedagofica y Tecnologica de Colombia (Colombia)

    1998-06-01

    This work shows the potentiometric conditions for ammonia sensor and its applications as tool in the quality control of waters and wastewater using the standard addition method. The Slope of the electrode demonstrated stability pursuant to the forecasts of the Nernst equation: 59.5 mV, with a control limit between 59.8 to 59.15 mV. The warning levels equally answered to the range 59.2-59.7 mV. At the determination by standard addition method the volume total volume was optimized, the same as the quantity of solution adjuster of the ionic stretch. Linear response range was in the interval 1.0-5.0*10``7 We analyzed real samples using the technique of Nesslerizacion the same as the Kjeldalh. The determination through ammonia electrode are sensitive, are not seen affected by the solids turbidity. (Author) 7 refs.

  14. Quality Control in Mammography: Image Quality and Patient Doses

    International Nuclear Information System (INIS)

    Ciraj Bjelac, O.; Arandjic, D.; Boris Loncar, B.; Kosutic, D.

    2008-01-01

    Mammography is method of choice for early detection of breast cancer. The purpose of this paper is preliminary evaluation the mammography practice in Serbia, in terms of both quality control indicators, i.e. image quality and patient doses. The survey demonstrated considerable variations in technical parameters that affect image quality and patients doses. Mean glandular doses ranged from 0.12 to 2.8 mGy, while reference optical density ranged from 1.2 to 2.8. Correlation between image contrast and mean glandular doses was demonstrated. Systematic implementation of quality control protocol should provide satisfactory performance of mammography units and maintain satisfactory image quality and keep patient doses as low as reasonably practicable. (author)

  15. Symptom Severity and Quality of Life Among Long-term Colorectal Cancer Survivors Compared With Matched Control Subjects: A Population-Based Study.

    Science.gov (United States)

    Hart, Tae L; Charles, Susan T; Gunaratne, Mekhala; Baxter, Nancy N; Cotterchio, Michelle; Cohen, Zane; Gallinger, Steven

    2018-03-01

    Data are lacking regarding physical functioning, psychological well-being, and quality of life among colorectal cancer survivors >10 years postdiagnosis. The purpose of this study was to examine self-reported physical functioning, quality of life, and psychological well-being in long-term colorectal cancer survivors compared with age- and sex-matched unaffected control subjects. Participants completed a cross-sectional survey. The colorectal cancer survivors and unaffected control subjects were recruited from the Ontario Familial Colorectal Cancer Registry. A population-based sample of colorectal cancer survivors (N = 296) and their age- and sex-matched unaffected control subjects (N = 255) were included. Survivors were, on average, 15 years postdiagnosis. Quality of life was measured with the Functional Assessment of Cancer Therapy-General scale, bowel dysfunction with the Memorial Sloan-Kettering Cancer Center scale, urinary dysfunction with the International Consultation on Incontinence Questionnaire-Short Form, fatigue with the Functional Assessment of Chronic Illness Therapy-Fatigue scale, and depression with the Center for Epidemiologic Studies-Depression scale. In linear mixed-model analyses adjusting for income, education, race, and comorbid medical conditions, survivors reported good emotional, functional, physical, and overall quality of life, comparable to control subjects. Fatigue and urinary functioning did not differ significantly between survivors and control subjects. Survivors reported significantly higher social quality of life and lower depression compared with unaffected control subjects. The only area where survivors reported significantly worse deficits was in bowel dysfunction, but the magnitude of differences was relatively small. Generalizability is limited by moderately low participation rates. Findings are likely biased toward healthy participants. No baseline assessment was available to examine change in outcomes over time. Long

  16. The effects of exercise on the quality of life of patients with breast cancer (the UMBRELLA Fit study) : study protocol for a randomized controlled trial

    NARCIS (Netherlands)

    Gal, Roxanne; Monninkhof, Evelyn M; Groenwold, Rolf H H; van Gils, Carla H; van den Bongard, Desiree H J G; Peeters, Petra H M; Verkooijen, Helena M; May, Anne M

    2017-01-01

    BACKGROUND: Meta-analyses of randomized controlled trials (RCTs) have shown that exercise has beneficial effects on quality of life (QoL) in patients with breast cancer. However, these effects were often small. Blinding in an exercise trial is not possible, which has the possible disadvantage of

  17. Internal control reporting and accounting quality : Insight "comply-or-explain" internal control regime

    OpenAIRE

    Cao Thi Thanh, Huyen; Cheung, Tina

    2010-01-01

    Nowadays, there exist two reporting regimes, rules-based and principle-based (comply-or-explain). In the rules-based environment, researchers have studied the relationship between internal control quality and accounting quality. Prior studies have suggested that reports on internal control are an effective way for investors to evaluate the quality of the firm‟s internal control. By having a sound system of internal control, it creates reliance upon the firm‟s financial reporting. Therefore, t...

  18. Quality control in the radioactive waste management

    International Nuclear Information System (INIS)

    Rzyski, B.M.

    1989-01-01

    Radioactive waste management as in industrial activities must mantain in all steps a quality control programme. This control extended from materials acquisition, for waste treatment, to the package deposition is one of the most important activities because it aims to observe the waste acceptance criteria in repositories and allows to guarantee the security of the nuclear facilities. In this work basic knowledges about quality control in waste management and some examples of adopted procedures in other countries are given. (author) [pt

  19. Implementing self sustained quality control procedures in a clinical laboratory.

    Science.gov (United States)

    Khatri, Roshan; K C, Sanjay; Shrestha, Prabodh; Sinha, J N

    2013-01-01

    Quality control is an essential component in every clinical laboratory which maintains the excellence of laboratory standards, supplementing to proper disease diagnosis, patient care and resulting in overall strengthening of health care system. Numerous quality control schemes are available, with combinations of procedures, most of which are tedious, time consuming and can be "too technical" whereas commercially available quality control materials can be expensive especially for laboratories in developing nations like Nepal. Here, we present a procedure performed at our centre with self prepared control serum and use of simple statistical tools for quality assurance. The pooled serum was prepared as per guidelines for preparation of stabilized liquid quality control serum from human sera. Internal Quality Assessment was performed on this sample, on a daily basis which included measurement of 12 routine biochemical parameters. The results were plotted on Levey-Jennings charts and analysed with quality control rules, for a period of one month. The mean levels of biochemical analytes in self prepared control serum were within normal physiological range. This serum was evaluated every day along with patients' samples. The results obtained were plotted on control charts and analysed using common quality control rules to identify possible systematic and random errors. Immediate mitigation measures were taken and the dispatch of erroneous reports was avoided. In this study we try to highlight on a simple internal quality control procedure which can be performed by laboratories, with minimum technology, expenditure, and expertise and improve reliability and validity of the test reports.

  20. A survey study comparing young adults with MS and healthy controls on self-esteem, self-efficacy, mood and quality of life.

    Science.gov (United States)

    Messmer Uccelli, Michele; Traversa, Silvia; Ponzio, Michela

    2016-09-15

    Studies have shown that people with multiple sclerosis (MS) report low levels of self-efficacy and self-esteem, high levels of anxiety and depression and reduced quality of life. The study aims to assess self-esteem, self-efficacy, mood and quality of life in young adults with MS and to compare them to a healthy control group. The age range for inclusion in the study was between 18 and 35years of age for both groups. Subjects with MS were recruited through the Italian MS Society. Healthy controls were recruited through social media and from a university undergraduate program. Subjects completed an anonymous online questionnaire combining various scales. Group differences on demographic data were assessed using parametric and non-parametric tests. Analyses of covariance (ANCOVA) were performed to evaluate differences between the two groups on scales of self-perception, mood and quality of life, adjusting for potentially confounding factors. Eighty-nine subjects with MS and 109 HC were included in the analysis. ANCOVA failed to demonstrate statistically significant differences between groups on self-esteem (F=0.11, p=0.743), self-efficacy (F=2.22, p=0.138), mood (anxiety F=0.03, p=0.855; depression F=0.06, p=0.812) and quality of life (F=0.08, p=0.772). This study demonstrated that young adults with MS and healthy controls have similar levels of self-esteem and self-efficacy and that they do not differ significantly on measures of mood and quality of life, as previously reported. Copyright © 2016. Published by Elsevier B.V.

  1. Development of phantom periapical for control quality

    International Nuclear Information System (INIS)

    Mendes, J.M.S.; Sales Junior, E.S.; Ferreira, F.C.L.; Paschoal, C.M.M.

    2015-01-01

    This study aimed to develop a dental phantom with cysts for evaluation of periapical radiographs that was tested in private dental offices in the city of Maraba, northern Brazil. Through some tests with the object simulator (phantom) were obtained 12 periapical radiographs (one in each of the offices visited) that waking up to the standards of Ordinance No. 453 were visually evaluated by observing the physical parameters of exposure (kVp and mA), time revelation of the radiographic film, later the other radiographs were visually compared with C6 ray set as the default. Among the results, it was found that only two of the twelve rays cysts could not be viewed and, therefore, these two images were deemed unsuitable for accurate diagnosis in the 10 images the cysts could be displayed, however according the images have different qualities comparisons. In addition, it can be concluded that the performance of the phantom was highly satisfactory showing to be efficient for use in quality control testing of dental X-rays, the quality control of radiographs and continuing education of dental professionals for a price much more accessible. (authors)

  2. Control by quality: proposition of a typology.

    Science.gov (United States)

    Pujo, P; Pillet, M

    The application of Quality tools and methods in industrial management has always had a fundamental impact on the control of production. It influences the behavior of the actors concerned, while introducing the necessary notions and formalizations, especially for production systems with little or no automation, which constitute a large part of the industrial activity. Several quality approaches are applied in the workshop and are implemented at the level of the control. In this paper, the authors present a typology of the various approaches that have successively influenced control, such as statistical process control, quality assurance, and continuous improvement. First the authors present a parallel between production control and quality organizational structure. They note the duality between control, which is aimed at increasing productivity, and quality, which aims to satisfy the needs of the customer. They also note the hierarchical organizational structure of these two systems of management with, at each level, the notion of a feedback loop. This notion is fundamental to any kind of decision making. The paper is organized around the operational, tactical, and strategic levels, by describing for each level the main methods and tools for control by quality. The overview of these tools and methods starts at the operational level, with the Statistical Process Control, the Taguchi technique, and the "six sigma" approach. On the tactical level, we find a quality system approach, with a documented description of the procedures introduced in the firm. The management system can refer here to Quality Assurance, Total Productive Maintenance, or Management by Total Quality. The formalization through procedures of the rules of decision governing the process control enhances the validity of these rules. This leads to the enhancement of their reliability and to their consolidation. All this counterbalances the human, intrinsically fluctuating, behavior of the control

  3. A preliminary study into performing routine tube output and automatic exposure control quality assurance using radiology information system data

    International Nuclear Information System (INIS)

    Charnock, P.; Jones, R.; Fazakerley, J.; Wilde, R.; Dunn, A. F.

    2011-01-01

    Data are currently being collected from hospital radiology information systems in the North West of the UK for the purposes of both clinical audit and patient dose audit. Could these data also be used to satisfy quality assurance (QA) requirements according to UK guidance? From 2008 to 2009, 731 653 records were submitted from 8 hospitals from the North West England. For automatic exposure control QA, the protocol from Inst. of Physics and Engineering in Medicine (IPEM) report 91 recommends that milli amperes per second can be monitored for repeatability and reproducibility using a suitable phantom, at 70-81 kV. Abdomen AP and chest PA examinations were analysed to find the most common kilo voltage used with these records then used to plot average monthly milli amperes per second with time. IPEM report 91 also recommends that a range of commonly used clinical settings is used to check output reproducibility and repeatability. For each tube, the dose area product values were plotted over time for two most common exposure factor sets. Results show that it is possible to do performance checks of AEC systems; however more work is required to be able to monitor tube output performance. Procedurally, the management system requires work and the benefits to the workflow would need to be demonstrated. (authors)

  4. Sensometrics for Food Quality Control

    DEFF Research Database (Denmark)

    Brockhoff, Per B.

    2011-01-01

    The industrial development of innovative and succesful food items and the measuring of food quality in general is difficult without actually letting human beings evaluate the products using their senses at some point in the process. The use of humans as measurement instruments calls for special...... attention in the modelling and data analysis phase. In this paper the focus is on sensometrics – the „metric“ side of the sensory science field. The sensometrics field is introduced and related to the fields of statistics, chemometrics and psychometrics. Some of the most commonly used sensory testing...

  5. Computer controlled quality of analytical measurements

    International Nuclear Information System (INIS)

    Clark, J.P.; Huff, G.A.

    1979-01-01

    A PDP 11/35 computer system is used in evaluating analytical chemistry measurements quality control data at the Barnwell Nuclear Fuel Plant. This computerized measurement quality control system has several features which are not available in manual systems, such as real-time measurement control, computer calculated bias corrections and standard deviation estimates, surveillance applications, evaluaton of measurement system variables, records storage, immediate analyst recertificaton, and the elimination of routine analysis of known bench standards. The effectiveness of the Barnwell computer system has been demonstrated in gathering and assimilating the measurements of over 1100 quality control samples obtained during a recent plant demonstration run. These data were used to determine equaitons for predicting measurement reliability estimates (bias and precision); to evaluate the measurement system; and to provide direction for modification of chemistry methods. The analytical chemistry measurement quality control activities represented 10% of the total analytical chemistry effort

  6. Safety of timber : An analysis of quality control options

    NARCIS (Netherlands)

    Kovryga, A.; Stapel, P.; Van de Kuilen, J.W.G.

    2014-01-01

    The quality assurance of timber properties is important for the safety of timber structures. In the current study, the quality control options of timber are analysed under the prism of the different growth regions. Therefore, these options - machine and output control - are simulated in accordance

  7. Quality control of geological voxel models using experts' gaze

    NARCIS (Netherlands)

    Maanen, P.P. van; Busschers, F.S.; Brouwer, A.M.; Meulen, M.J. van der; Erp, J.B.F. van

    2015-01-01

    Due to an expected increase in geological voxel model data-flow and user demands, the development of improved quality control for such models is crucial. This study explores the potential of a new type of quality control that improves the detection of errors by just using gaze behavior of 12

  8. Quality Control of Geological Voxel Models using Experts' Gaze

    NARCIS (Netherlands)

    van Maanen, Peter-Paul; Busschers, Freek S.; Brouwer, Anne-Marie; van der Meulendijk, Michiel J.; van Erp, Johannes Bernardus Fransiscus

    Due to an expected increase in geological voxel model data-flow and user demands, the development of improved quality control for such models is crucial. This study explores the potential of a new type of quality control that improves the detection of errors by just using gaze behavior of 12

  9. Study rationale and design of OPTIMISE, a randomised controlled trial on the effect of benchmarking on quality of care in type 2 diabetes mellitus

    Science.gov (United States)

    2011-01-01

    Background To investigate the effect of physician- and patient-specific feedback with benchmarking on the quality of care in adults with type 2 diabetes mellitus (T2DM). Methods Study centres in six European countries were randomised to either a benchmarking or control group. Physicians in both groups received feedback on modifiable outcome indicators (glycated haemoglobin [HbA1c], glycaemia, total cholesterol, high density lipoprotein-cholesterol, low density lipoprotein [LDL]-cholesterol and triglycerides) for each patient at 0, 4, 8 and 12 months, based on the four times yearly control visits recommended by international guidelines. The benchmarking group also received comparative results on three critical quality indicators of vascular risk (HbA1c, LDL-cholesterol and systolic blood pressure [SBP]), checked against the results of their colleagues from the same country, and versus pre-set targets. After 12 months of follow up, the percentage of patients achieving the pre-determined targets for the three critical quality indicators will be assessed in the two groups. Results Recruitment was completed in December 2008 with 3994 evaluable patients. Conclusions This paper discusses the study rationale and design of OPTIMISE, a randomised controlled study, that will help assess whether benchmarking is a useful clinical tool for improving outcomes in T2DM in primary care. Trial registration NCT00681850 PMID:21939502

  10. TRAINING SYSTEM OF FUTURE SPECIALISTS: QUALITY CONTROL

    Directory of Open Access Journals (Sweden)

    Vladimir A. Romanov

    2015-01-01

    Full Text Available The aim of the investigation is development of innovative strategy of quality control training of engineers and skilled workers (hereinafter – future specialists in educational professional organizations on the principles of social partnership.Methods. Theoretic: theoretic and methodological analysis, polytheoretic synthesis, modeling. Empirical: research and generalization of the system, process and competence – based approaches experience, experiment, observation, surveys, expert evaluation, SWOT-analysis as a method of strategic planning which is to identify the internal and external factors (socio-cultural of the organization surrounding.Results. The strategy of the development of the process of quality control training in educational professional organizations and a predictive model of the system of quality control training for future engineers and workers have been created on the analysis and synthesis of a quantitative specification of the quality, the obtained experience and success in control training of future specialists in educational professional organizations in recent economic and educational conditions.Scientific novelty. There has been built a predicative model of quality control training of future specialists to meet modern standards and the principles of social partnership; the control algorithm of the learning process, developed in accordance with the standards (international of quality ISO in the implementation of the quality control systems of the process approach (matrix-based responsibility, competence and remit of those responsible for the education process in the educational organization, the «problem» terms and diagnostic tools for assessing the quality of professional training of future specialists. The perspective directions of innovation in the control of the quality of future professionals training have been determined; the parameters of a comprehensive analysis of the state of the system to ensure the

  11. Cavity quantum electrodynamics studies with site-controlled InGaAs quantum dots integrated into high quality microcavities

    DEFF Research Database (Denmark)

    Reitzenstein, S.; Schneider, C.; Albert, F.

    2011-01-01

    Semiconductor quantum dots (QDs) are fascinating nanoscopic structures for photonics and future quantum information technology. However, the random position of self-organized QDs inhibits a deterministic coupling in devices relying on cavity quantum electrodynamics (cQED) effects which complicates......, e.g., the large scale fabrication of quantum light sources. As a result, large efforts focus on the growth and the device integration of site-controlled QDs. We present the growth of low density arrays of site-controlled In(Ga)As QDs where shallow etched nanoholes act as nucleation sites...... linewidth, the oscillator strength and the quantum efficiency. A stacked growth of strain coupled SCQDs forming on wet chemically etched nanoholes provide the smallest linewidth with an average value of 210 μeV. Using time resolved photoluminescence studies on samples with a varying thickness of the capping...

  12. CONCRETE STRUCTURES' QUALITY CONTROL IN PRACTICE

    OpenAIRE

    Dolaček-Alduk, Zlata; Blanda, Miroslav

    2011-01-01

    The Croatian civil engineering is characterized by a lack of systematic approach to planning, control and quality assurance in all phases of project realization. The results obtained in establishing the quality management system in some segments of civil engineering production represent initial trends in solving this problem. Benefits are of two types: the achievement of quality for the contractor and obtaining that quaity is being achieved for clients. Execution of concrete structures is a c...

  13. Investigating sexual problems, psychological distress and quality of life in female patients with Takotsubo cardiomyopathy: A prospective case-control study.

    Science.gov (United States)

    Saffari, Mohsen; Lin, Chung-Ying; Broström, Anders; Mårtensson, Jan; Malm, Dan; Burri, Andrea; Fridlund, Bengt; Pakpour, Amir H

    2017-10-01

    Takotsubo cardiomyopathy (TSCM) has detrimental effects on both physical and psychological health of sufferers. However, little is known whether TSCM also affects sexual functioning in female patients. The aim of this study was to investigate psychological distress (depression and anxiety), health-related quality of life, and sexual functioning in women with TSCM and compare them with women with acute myocardial infarction and with healthy controls. A three group prospective case-control design was used. Female patients with TSCM or acute myocardial infarction, as well as healthy controls (94 in each group), were recruited across eight Iranian university hospitals. Data were collected at baseline and after six and 18 months using the Hospital Anxiety and Depression Scale, the Short Form-12, the Female Sexual Function Index and the Female Sexual Distress Scale. Multilevel logistic regression was conducted. The TSCM group showed worst sexual functioning and the highest level of anxiety and depression at baseline ( pquality of life at baseline, which was lower in both groups compared with the healthy controls ( pquality of life showed a significant change over time, especially in the TSCM group, with health-related quality of life decreasing, while anxiety and depression were increasing. Compared with the acute myocardial infarction and healthy control groups, the TSCM group showed a higher prevalence of sexual problems (odds ratios = 3.10 and 2.28, respectively) across time. Moreover, sexual functioning was found to be a mediator between anxiety and health-related quality of life in the TSCM group. Depression, anxiety, health-related quality of life, and sexual dysfunction tend to increase over time in female patients with TSCM; thus, healthcare providers should pay attention to these problems and provide appropriate treatment where necessary.

  14. A quality control manual for oral radiology

    International Nuclear Information System (INIS)

    Peixoto, J.E.; Ferreira, R.S.; Bessa, S.O.; Domingues, C.; Gomes, C.A.; Oliveira, S.L.G.; Ortiz, J.A.P.

    1988-01-01

    A quality control manual for oral radiology is showed. The X-ray equipment used for this activity is described, such as the X-ray tube, collimator. The high tension in X-ray tube, the spectra, the quality and the quantity of radiation and the X-ray intensity are also analysed. (C.G.C.) [pt

  15. Quality control of gamma radiation measuring systems

    International Nuclear Information System (INIS)

    Surma, M.J.

    2002-01-01

    The problem of quality control and assurance of gamma radiation measuring systems has been described in detail. The factors deciding of high quality of radiometric measurements as well as statistical testing and calibration of measuring systems have been presented and discussed

  16. Net analyte signal based statistical quality control

    NARCIS (Netherlands)

    Skibsted, E.T.S.; Boelens, H.F.M.; Westerhuis, J.A.; Smilde, A.K.; Broad, N.W.; Rees, D.R.; Witte, D.T.

    2005-01-01

    Net analyte signal statistical quality control (NAS-SQC) is a new methodology to perform multivariate product quality monitoring based on the net analyte signal approach. The main advantage of NAS-SQC is that the systematic variation in the product due to the analyte (or property) of interest is

  17. The regulatory maze of quality control

    International Nuclear Information System (INIS)

    Stone, T.I.

    1987-01-01

    The appropriateness of specific procedures within a quality control program becomes difficult to assess when an attempt is made to collate all of the available information. This task is discussed from the perspective of the Joint Commission (JCAH Accreditation Manual), HHS(quality assurance program recommendations), equipment manufacturers maintenance schedules, and radiology administrative cost concerns

  18. Quality Control Guidelines for SAM Biotoxin Methods

    Science.gov (United States)

    Learn more about quality control guidelines and recommendations for the analysis of samples using the pathogen methods listed in EPA's Selected Analytical Methods for Environmental Remediation and Recovery (SAM).

  19. Quality Control Guidelines for SAM Radiochemical Methods

    Science.gov (United States)

    Learn more about quality control guidelines and recommendations for the analysis of samples using the radiochemistry methods listed in EPA's Selected Analytical Methods for Environmental Remediation and Recovery (SAM).

  20. Quality Control Guidelines for SAM Pathogen Methods

    Science.gov (United States)

    Learn more about quality control guidelines and recommendations for the analysis of samples using the biotoxin methods listed in EPA's Selected Analytical Methods for Environmental Remediation and Recovery (SAM).

  1. Quality Control Guidelines for SAM Chemical Methods

    Science.gov (United States)

    Learn more about quality control guidelines and recommendations for the analysis of samples using the chemistry methods listed in EPA's Selected Analytical Methods for Environmental Remediation and Recovery (SAM).

  2. Metallographic quality control of welding and brazing

    International Nuclear Information System (INIS)

    Slaughter, G.M.

    1979-01-01

    The value of metallography in assuring integrity in the fabrication of metal and components in energy systems is summarized. Metallography also plays an integral role in quality control of welded and brazed joints

  3. Quality Controlled Local Climatological Data (QCLCD) Publication

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Quality Controlled Local Climatological Data (QCLCD) contains summaries from major airport weather stations that include a daily account of temperature extremes,...

  4. Quality control during construction of power plants

    International Nuclear Information System (INIS)

    Hartstern, R.F.

    1982-01-01

    This paper traces the background and examines the necessity for a program to control quality during the construction phase of a power plant. It also attempts to point out considerations for making these programs cost effective

  5. Performance and quality control of scintillation cameras

    International Nuclear Information System (INIS)

    Moretti, J.L.; Iachetti, D.

    1983-01-01

    Acceptance testing, quality and control assurance of gamma-cameras are a part of diagnostic quality in clinical practice. Several parameters are required to achieve a good diagnostic reliability: intrinsic spatial resolution, spatial linearity, uniformities, energy resolution, count-rate characteristics, multiple window spatial analysis. Each parameter was measured and also estimated by a test easy to implement in routine practice. Material required was a 4028 multichannel analyzer linked to a microcomputeur, mini-computers and a set of phantoms (parallel slits, diffusing phantom, orthogonal hole transmission pattern). Gamma-cameras on study were:CGR 3400, CGR 3420, G.E.4000. Siemens ZLC 75 and large field Philips. Several tests proposed by N.E.M.A. and W.H.O. have to be improved concerning too punctual spatial determinations during distortion measurements with multiple window. Contrast control of image need to be monitored with high counting rate. This study shows the need to avoid punctual determinations and the interest to give sets of values of the same parameter on the whole field and to report mean values with their standard variation [fr

  6. A quality control study on cytotechnologist-cytopathologist concordance and its relationship to the number of dots on the slide.

    Science.gov (United States)

    Bongiovanni, Massimo; De Saussure, Barbara; Kumar, Neeta; Pache, Jean-Claude; Cibas, Edmund S

    2009-01-01

    To study cytotechnologist (CT)-cytopathologist (CP) concordance for evaluating individual CTs' performance and for quality assurance and educational feedback. The interpretations of individual CTs were compared with the final interpretations (according to the 2001 Bethesda System) of the CP. Concordance percentages and kappa values were calculated for each CT and correlated with the numbers of dots on each slide, years of experience and percentage of work hours devoted to cytology. A total of 10,453 Pap tests were screened by 9 CTs during one year, out of which 993 (9.5%) were referred to one CP for a final interpretation. Mean concordance between the aggregate CT interpretations and those of the CP was 65.5%. Five CTs had good concordance, 3 had moderately good concordance, and one had surprisingly poor concordance that contrasted with good subjective impressions. No correlation was found between concordance and the average number of dots per slide, screening experience in cervicovaginal cytology or percentage of work hours devoted to cytology. Monitoring CT-CP concordance rates can unveil performance issues not detected by subjective impressions. An excessive number of dots per slide may not reflect poor diagnostic precision so much as a lack of confidence in interpretation.

  7. Developing methods of controlling quality costs

    Directory of Open Access Journals (Sweden)

    Gorbunova A. V.

    2017-01-01

    Full Text Available The article examines issues of managing quality costs, problems of applying economic methods of quality control, implementation of progressive methods of quality costs management in enterprises with the view of improving the efficiency of their evaluation and analysis. With the aim of increasing the effectiveness of the cost management mechanism, authors introduce controlling as a tool of deviation analysis from the standpoint of the process approach. A list of processes and corresponding evaluation criteria in the quality management system of enterprises is introduced. Authors also introduce the method of controlling quality costs and propose it for the practical application, which allows them to determine useful and unnecessary costs at the existing operating plant. Implementing the proposed recommendations in the system of cost management at an enterprise will allow to improve productivity of processes operating and reduce wasted expense on the quality of the process on the basis of determining values of useful and useless costs of quality according to criteria of processes functioning in the system of quality management.

  8. Toward standardising gamma camera quality control procedures

    International Nuclear Information System (INIS)

    Alkhorayef, M.A.; Alnaaimi, M.A.; Alduaij, M.A.; Mohamed, M.O.; Ibahim, S.Y.; Alkandari, F.A.; Bradley, D.A.

    2015-01-01

    Attaining high standards of efficiency and reliability in the practice of nuclear medicine requires appropriate quality control (QC) programs. For instance, the regular evaluation and comparison of extrinsic and intrinsic flood-field uniformity enables the quick correction of many gamma camera problems. Whereas QC tests for uniformity are usually performed by exposing the gamma camera crystal to a uniform flux of gamma radiation from a source of known activity, such protocols can vary significantly. Thus, there is a need for optimization and standardization, in part to allow direct comparison between gamma cameras from different vendors. In the present study, intrinsic uniformity was examined as a function of source distance, source activity, source volume and number of counts. The extrinsic uniformity and spatial resolution were also examined. Proper standard QC procedures need to be implemented because of the continual development of nuclear medicine imaging technology and the rapid expansion and increasing complexity of hybrid imaging system data. The present work seeks to promote a set of standard testing procedures to contribute to the delivery of safe and effective nuclear medicine services. - Highlights: • Optimal parameters for quality control of the gamma camera are proposed. • For extrinsic and intrinsic uniformity a minimum of 15,000 counts is recommended. • For intrinsic flood uniformity the activity should not exceed 100 µCi (3.7 MBq). • For intrinsic uniformity the source to detector distance should be at least 60 cm. • The bar phantom measurement must be performed with at least 15 million counts.

  9. Long-term scar quality after hydrosurgical versus conventional debridement of deep dermal burns (HyCon trial): study protocol for a randomized controlled trial.

    Science.gov (United States)

    Legemate, Catherine M; Goei, Harold; Middelkoop, Esther; Oen, Irma M M H; Nijhuis, Tim H J; Kwa, Kelly A A; van Zuijlen, Paul P M; Beerthuizen, Gerard I J M; Nieuwenhuis, Marianne K; van Baar, Margriet E; van der Vlies, Cornelis H

    2018-04-19

    Deep dermal burns require tangential excision of non-viable tissue and skin grafting to improve wound healing and burn-scar quality. Tangential excision is conventionally performed with a knife, but during the last decade hydrosurgery has become popular as a new tool for tangential excision. Hydrosurgery is generally thought to be a more precise and controlled manner of burn debridement leading to preservation of viable tissue and, therefore, better scar quality. Although scar quality is considered to be one of the most important outcomes in burn surgery today, no randomized controlled study has compared the effect of these two common treatment modalities with scar quality as a primary outcome. The aim of this study is, therefore, to compare long-term scar quality after hydrosurgical versus conventional tangential excision in deep dermal burns. A multicenter, randomized, intra-patient, controlled trial will be conducted in the Dutch burn centers of Rotterdam, Beverwijk, and Groningen. All patients with deep dermal burns that require excision and grafting are eligible. Exclusion criteria are: a burn wound burned > 30%, full-thickness burns, chemical or electrical burns, infected wounds (clinical symptoms in combination with positive wound swabs), insufficient knowledge of the Dutch or English language, patients that are unlikely to comply with requirements of the study protocol and follow-up, and patients who are (temporarily) incompetent because of sedation and/or intubation. A total of 137 patients will be included. Comparable wound areas A and B will be appointed, randomized and either excised conventionally with a knife or with the hydrosurgery system. The primary outcome is scar quality measured by the observer score of the Patient and Observer Scar Assessment Scale (POSAS); a subjective scar-assessment instrument, consisting of two separate six-item scales (observer and patient) that are both scored on a 10-point rating scale. This study will contribute to

  10. Quality assurance and quality control in mammography: A review

    International Nuclear Information System (INIS)

    BenComo, Jose A.

    2000-01-01

    A mammogram is among the most technically demanding radiographic procedures. The early detection of breast cancer relies on the radiologist's ability to perceive subtle changes in the image that are only perceptible with high-quality imaging. Early detection of breast cancer is only as reliable as the mammogram with which a diagnosis is made, and a mammogram is only as accurate as the system that produces it. A quality assurance (QA) program maximizes the likelihood that the mammographic images will provide adequate diagnostic information for the least possible radiation exposure and cost to the patient. The QA program monitors each phase of operation of the imaging facility beginning with the request for an examination and ending with the interpretation of the referring physician and ensures that the imaging equipment used for the examination will yield the information desired. Because image quality is the most important technical aspect of mammography, this review summarizes the most important QA and quality control issues

  11. Quality control and analysis of radiotracer compounds

    International Nuclear Information System (INIS)

    Sheppard, G.; Thomson, R.

    1977-01-01

    Special emphasis was on the problems and errors possible in quality control and analysis. The principles underlying quality control were outlined, and analytical techniques applicable to radiotracers were described. Chapter concluded with a selection of examples showing the effects of impurities on the use of radiotracers. The subject of quality control and analysis was treated from the viewpoint of the user and those research workers who need to synthesize and analyze their own radiochemicals. The quality characteristics for radiotracers are of two kinds, valuable or attributive. These were discussed in the chapter. For counting low radioactive concentration, scintillation techniques are in general use, whereas ionization techniques are now used mainly for the measurement of high radioactive concentrations or large quantities of radioactivity, for scanning chromatograms, and a number of very specific purposes. Determination of radionuclidic purity was discussed. Use of radiotracers in pharmaceuticals were presented. 4 figures, 6 tables

  12. 20. Quality assurance and quality control in nuclear medicine

    International Nuclear Information System (INIS)

    Vavrejn, B.

    1989-01-01

    Quality control principles to be applied when taking over and using nuclear medicine instrumentation are given. Such instrumentation includes activity meters, gamma detectors for in vitro measurements (manual or automated instruments), gamma detectors for in vivo measurements (with one or several probes), 'movable' scintigraphs and 'steady' scintigraphs (gamma cameras). (Z.S.)

  13. Case Study on Quality Education

    Science.gov (United States)

    Habib, Zahida

    2011-01-01

    Quality of Education, especially at Primary level, is an important issue to be discussed at the International Forum. This study highlights the quality of primary education through a comparison of the quality of Community Model Schools and Govt. Girls Primary Schools in Pakistan. Community Model Schools were established under Girls Primary…

  14. Obsessive-Compulsive Disorder and quality of life outcomes: protocol for a systematic review and meta-analysis of cross-sectional case-control studies

    Directory of Open Access Journals (Sweden)

    Anna Coluccia

    2015-06-01

    Full Text Available Background. Obsessive-compulsive Disorder (OCD is a chronic disabling psychological condition, which can severely affect quality of life (QOL. Growing interest has been dedicated to assessing which domains of QOL are more severely affected in patients with OCD. However, research yielded conflicting findings. Investigating QOL in OCD could suggest the need for integration of interventions aimed at improving those specific domains more severely impaired by obsessions and compulsions.Methods. We will conduct a systematic review of cross-sectional case-control studies according to PRISMA guidelines, where patients with a primary OCD diagnosis were compared on QOL outcomes with healthy controls. Primary objectives will be to examine differences in QOL outcomes between patients with OCD and healthy controls, and to assess which QOL domains are more severely impaired in patients compared with controls, particularly subjective well-being, social and interpersonal functioning, work functioning, and family functioning. Subsequently, the study will investigate potential moderators of QOL in OCD, including participants characteristics (age, sex, presence of comorbid personality disorders, OCD symptom severity, severity of concurrent depressive symptoms, duration of OCD symptoms, and generational cohort, and study characteristics (date of publication and methodological quality of the studies. Online databases will be searched (PsycINFO, PubMED, Science Direct, Cinahl, Biological Abstracts, Psyclit, Embase, The Cochrane Central Register of Controlled Trials, and Google Scholar. To locate unpublished records, conference abstracts, doctoral dissertations and theses will be handsearched, and experts will be contacted. Statistical analyses will be performed though random effect model meta-analysis. Risk of bias assessments will be conducted using the instrument Methodological Index for Non-Randomized Studies.

  15. Health Related Quality of Life and Weight Self-Efficacy of Life Style among Normal-Weight, Overweight and Obese Iranian Adolescents: A Case Control Study

    Directory of Open Access Journals (Sweden)

    Seyedeh Fatemeh Miri

    2017-11-01

    Full Text Available Background: Identifying and investigating the factors influencing self-efficacy and eventually health related quality of life (HRQoL can be an important step toward the prevention and treatment of the obesity. The aim of the study was to compare weight self-efficacy and HRQoL among normal-weight, overweight and obese Iranian adolescents. Materials and Methods In this case-control study, 118 obese and overweight adolescents (case group and 118 adolescents with normal weight (control group were recruited. Adolescent's anthropometric characteristics were measured. The Weight Efficacy Lifestyle Questionnaire (WEL, pediatric quality of life inventory (PedsQLTM 4.0 and self-reported physical activity were completed by the adolescents. Results: Multivariate logistic regression adjusting for various confounders indicated that overweight and obese adolescents were less likely to be physically active (adjusted odds ratio, AOR= 0.66; 95% confidence interval [CI], 0.48 to 0.911, had lower ability to cope with social pressure (AOR= 0.54; 95% CI, 0.32 to 0.93, involved in less positive activities (AOR= 0.53; 95% CI, 0.37 to 0.75, and felt more negative emotions (AOR= 0.23; 95% CI, 0.14 to 0.36 than their normal-weight counterparts. Moreover, obese and overweight adolescents were more likely to report deteriorated quality of life in all PedsQL subscales than those with normal weight P

  16. The Role of Locus of Control and Attributional Style in Coping Strategies and Quality of Life among Iranian Breast Cancer and Colorectal Cancer Patients: A Pilot Study

    Directory of Open Access Journals (Sweden)

    Farzad Goli

    2014-01-01

    Full Text Available Background: The influence of various psychological factors and coping mechanisms on quality of life (QOL in cancer patients has been well established. We evaluated locus of control and attributional styles, and their association with coping styles and quality of life (QOL among Iranian cancer patients. Methods: This cross-sectional study was conducted on patients with breast cancer and patients with colorectal cancer in stage I to III. Patients were assessed for demographic and disease characteristics, cancer-related symptoms, locus of control, attributional styles, coping styles, and QOL. Results: From 140 invited patients, 100 patients participated in the study. Data of 55 patients with breast cancer and 22 patients with colorectal cancer were appropriate and included for analysis (mean age of 47.5 ± 7.9 years, 89.6% female. Factors positively associated with QOL included educational level, internal locus of control, overall hopefulness, and confrontive, optimistic, and self-reliant coping styles (r = 0.228 to 0.426. Factors negatively associated with QOL included age, symptoms severity, overall hopelessness, and fatalistic and emotive coping styles (r = -0.221 to -0.674. Internal locus of control and hopefulness were associated with confrontive/adaptive coping styles (r = 0.226 to 0.381, while external locus of control and hopelessness were associated with evasive/maladaptive coping styles (r = 0.208 to 0.381. Conclusion: These results indicate that internal locus of control, hopefulness, and positive attributional styles are associated with more adaptive/confrontive coping strategies and better QOL in Iranian cancer patients. Further studies with more comprehensive psychosocial evaluation in a larger sample of cancer patients are warranted.

  17. Quality of Life in Rectal Cancer Patients After Chemoradiation: Watch-and-Wait Policy Versus Standard Resection - A Matched-Controlled Study.

    Science.gov (United States)

    Hupkens, Britt J P; Martens, Milou H; Stoot, Jan H; Berbee, Maaike; Melenhorst, Jarno; Beets-Tan, Regina G; Beets, Geerard L; Breukink, Stéphanie O

    2017-10-01

    Fifteen to twenty percent of patients with locally advanced rectal cancer have a clinical complete response after chemoradiation therapy. These patients can be offered nonoperative organ-preserving treatment, the so-called watch-and-wait policy. The main goal of this watch-and-wait policy is an anticipated improved quality of life and functional outcome in comparison with a total mesorectal excision, while maintaining a good oncological outcome. The aim of this study was to compare the quality of life of watch-and-wait patients with a matched-controlled group of patients who underwent chemoradiation and surgery (total mesorectal excision group). This was a matched controlled study. This study was conducted at multiple centers. The study population consisted of 2 groups: 41 patients after a watch-and-wait policy and 41 matched patients after chemoradiation and surgery. Patients were matched on sex, age, tumor stage, and tumor height. All patients were disease free at the moment of recruitment after a minimal follow-up of 2 years. Quality of life was measured by validated questionnaires covering general quality of life (Short Form 36, European Organization for Research and Treatment of Cancer QLQ-C30), disease-specific total mesorectal excision (European Organization for Research and Treatment of Cancer QLQ-CR38), defecation problems (Vaizey and low anterior resection syndrome scores), sexual problems (International Index of Erectile Function and Female Sexual Function Index), and urinary dysfunction (International Prostate Symptom Score). The watch-and-wait group showed better physical and cognitive function, better physical and emotional roles, and better global health status compared with the total mesorectal excision group. The watch-and-wait patients showed fewer problems with defecation and sexual and urinary tract function. This study only focused on watch-and-wait patients who achieved a sustained complete response for 2 years. In addition, this is a study

  18. Quality control in 99m technetium radiopharmaceuticals

    International Nuclear Information System (INIS)

    Leon Cabana, Alba

    1994-01-01

    This work means about the quality control in Tc radiopharmaceuticals preparation at hospitalary levels. Several steps must be used in a Nuclear Medicine Laboratory, such as proceeding,radiopharmaceuticals kits preparation, and dispensation materials,glasses,stopper,physical aspects,identification,ph control,storage,and reactif kits

  19. Effect of quality control implementation on image quality of radiographic films and irradiation doses to patients

    International Nuclear Information System (INIS)

    Cheng Yuxi; Zhou Qipu; Ge Lijuan; Hou Changsong; Qi Xuesong; Yue Baorong; Wang Zuoling; Wei Kedao

    1999-01-01

    Objective: To study the changes in the image quality of radiographic films and the irradiation doses to patients after quality control (QC) implementation. Methods: The entrance surface doses (ESD) to patients measured with TLD and the image quality of radiographic films were evaluated on the basis of CEC image quality criteria. Results: The ESD to patients were significantly reduced after QC implementation (P 0.05), but the post-QC image quality was significantly improved in chest PA, lumbar spine AP and pelvis AP(P0.01 or P<0.05). Conclusion: Significantly reduced irradiation dose with improved image quality can be obtained by QC implementation

  20. Quality and Quantity of Rehabilitation Exercises Delivered By A 3-D Motion Controlled Camera: A Pilot Study.

    Science.gov (United States)

    Komatireddy, Ravi; Chokshi, Anang; Basnett, Jeanna; Casale, Michael; Goble, Daniel; Shubert, Tiffany

    2014-08-01

    Tele-rehabiliation technologies that track human motion could enable physical therapy in the home. To be effective, these systems need to collect critical metrics without PT supervision both in real time and in a store and forward capacity. The first step of this process is to determine if PTs (PTs) are able to accurately assess the quality and quantity of an exercise repetition captured by a tele-rehabilitation platform. The purpose of this pilot project was to determine the level of agreement of quality and quantity of an exercise delivered and assessed by the Virtual Exercise Rehabilitation Assistant (VERA), and seven PTs. Ten healthy subjects were instructed by a PT in how to perform four lower extremity exercises. Subjects then performed each exercises delivered by VERA which counted repetitions and quality. Seven PTs independently reviewed video of each subject's session and assessed repetitions quality. The percent difference in total repetitions and analysis of the distribution of rating repetition quality was assessed between the VERA and PTs. The VERA counted 426 repetitions across 10 subjects performing the four different exercises while the mean repetition count from the PT panel was 426.7 (SD = 0.8). The VERA underestimated the total repetitions performed by 0.16% (SD = 0.03%, 95% CI 0.12 - 0. 22). Chi square analysis across raters was χ 2 = 63.17 (df = 6, p<.001), suggesting significant variance in at least one rater. The VERA count of repetitions was accurate in comparison to a seven member panel of PTs. For exercise quality the VERA was able to rate 426 exercise repetitions across 10 patients and four different exercises in a manner consistent with five out of seven experienced PTs.

  1. Effects of exercise training with traditional dancing on functional capacity and quality of life in patients with schizophrenia: a randomized controlled study.

    Science.gov (United States)

    Kaltsatou, A; Kouidi, E; Fountoulakis, K; Sipka, C; Theochari, V; Kandylis, D; Deligiannis, A

    2015-09-01

    To examine the effects of an eight-month exercise training programme with Greek traditional dancing on functional capacity and quality of life in patients with schizophrenia. Randomized controlled trial. Sports Medicine Laboratory. A total of 31 patients, aged 59.9 ± 14.1 years. They were randomly assigned either to a Greek traditional dancing programme (Group A) or to a sedentary control group (Group B). A functional capacity assessment was performed at baseline and the end of the study. Global Assessment of Functioning Scale and Positive and Negative Syndrome Scale were also used. Quality of life was examined using the Quality of Life and Satisfaction questionnaire. After the eight months, Group A increased walking distance in the 6-minute walk test (328.4 ± 35.9 vs. 238.0 ± 47.6 m), sit-to-stand test (19.1 ± 1.8 vs. 25.1 ± 1.4 seconds), Berg Balance Scale score (53.1 ± 2.1 vs. 43.2 ± 6.7), lower limbs maximal isometric force (77.7 ± 25.7 vs. 51.0 ± 29.8 lb), Positive and Negative Syndrome Scale total score (77.0 ± 23.1 vs. 82.0 ± 24.4), Global Assessment of Functioning Scale total score (51.3 ± 15.5 vs. 47.7 ± 13.3) and Quality of Life total score (34.9 ± 5.2 vs. 28 ± 4.5), compared with Group B. Our results demonstrate that Greek traditional dances improve functional capacity and quality of life in patients with schizophrenia. © The Author(s) 2014.

  2. Quality of life following total mastectomy with and without reconstruction versus breast-conserving surgery for breast cancer: A case-controlled cohort study.

    Science.gov (United States)

    Howes, Benjamin H L; Watson, David I; Xu, Chris; Fosh, Beverley; Canepa, Maximiliano; Dean, Nicola R

    2016-09-01

    Patient-reported outcomes and quality of life following mastectomy are not well understood. This study evaluates the quality of life following surgery for breast cancer and compares outcomes following breast-conserving surgery versus total mastectomy with or without reconstruction. A case-controlled cross-sectional study was conducted using the validated BREAST-Q™ questionnaire and a study-specific questionnaire to determine patient's views about surgical outcomes. Questionnaires were completed by patients following breast-conserving surgery and total mastectomy with or without reconstruction and by controls without breast cancer. A one-way ANOVA was used to compare mean BREAST-Q™ scores between groups and post hoc analysis using Tukey's and Kruskal-Wallis tests. BREAST-Q™ questionnaires were completed by 400 women (123 controls, 97 breast conservations, 93 mastectomies without reconstruction, 87 mastectomies with reconstruction). Women who had undergone mastectomy and reconstruction had higher scores in satisfaction with breast and sexual well-being domains compared with women who had breast-conserving surgery, and women who had total mastectomy without reconstruction had the lowest scores in these two domains. There was no difference in psychosocial well-being between the groups. Women who had undergone breast-conserving surgery scored the lowest in the physical well-being chest domain and the majority reported breast asymmetry. Our study suggests that women who undergo total mastectomy and breast reconstruction for cancer achieve a quality-of-life outcome that is at least as good as that following breast-conserving surgery. Furthermore, breast conservation has been found to be associated with lower physical well-being (i.e., more pain and discomfort) in the chest area and poorer sexual well-being outcomes. Copyright © 2016 British Association of Plastic, Reconstructive and Aesthetic Surgeons. All rights reserved.

  3. Is Low-field NMR a Complementary Tool to GC-MS in Quality Control of Essential Oils? A Case Study: Patchouli Essential Oil.

    Science.gov (United States)

    Krause, Andre; Wu, Yu; Tian, Runtao; van Beek, Teris A

    2018-04-24

    High-field NMR is an expensive and important quality control technique. In recent years, cheaper and simpler low-field NMR has become available as a new quality control technique. In this study, 60 MHz 1 H-NMR was compared with GC-MS and refractometry for the detection of adulteration of essential oils, taking patchouli essential oil as a test case. Patchouli essential oil is frequently adulterated, even today. In total, 75 genuine patchouli essential oils, 10 commercial patchouli essential oils, 10 other essential oils, 17 adulterants, and 1 patchouli essential oil, spiked at 20% with those adulterants, were measured. Visual inspection of the NMR spectra allowed for easy detection of 14 adulterants, while gurjun and copaiba balsams proved difficult and one adulterant could not be detected. NMR spectra of 10 random essential oils differed not only strongly from patchouli essential oil but also from one another, suggesting that fingerprinting by low-field NMR is not limited to patchouli essential oil. Automated chemometric evaluation of NMR spectra was possible by similarity analysis (Mahalanobis distance) based on the integration from 0.1 - 8.1 ppm in 0.01 ppm increments. Good quality patchouli essential oils were recognised as well as 15 of 17 deliberate adulterations. Visual qualitative inspection by GC-MS allowed for the detection of all volatile adulterants. Nonvolatile adulterants, and all but one volatile adulterant, could be detected by semiquantitation. Different chemometric approaches showed satisfactory results. Similarity analyses were difficult with nonvolatile adulterants. Refractive index measurements could detect only 8 of 17 adulterants. Due to advantages such as simplicity, rapidity, reproducibility, and ability to detect nonvolatile adulterants, 60 MHz 1 H-NMR is complimentary to GC-MS for quality control of essential oils. Georg Thieme Verlag KG Stuttgart · New York.

  4. GC/FID-based authentication of Baccharis trimera: a quality control study of products commercialized in Curitiba and metropolitan region (Brazil

    Directory of Open Access Journals (Sweden)

    Lia M. S. de Ferrante

    Full Text Available Baccharis trimera (carqueja is a medicinal plant used for stomach pain, bad digestion, heart bum, kidney problems and constipation. The objective of the present work was a quality study of carqueja commercialized in Curitiba and metropolitan region (Paraná-Brazil using gas chromatography techniques (GC/FID for analyses of the essential oil, which was extracted through hydrodistillation using a Clevenger system. Macro and microscopic analyses were also done. Some samples were contaminated by other species of plants, fungi and small insects, some of them could be identified. Among all samples, 21 showed similar chromatographic profile to the standard oil, and 7 had different profile in relation to the standard. The chromatogram analyses showed that most of the analyzed samples had the similar profile as the standard oil of Baccharis trimera. GC/FID-based authentication of Baccharis trimera may be useful as a rapid tool to ensure quality control and safety monitoring of this kind of herbal pharmaceuticals.

  5. Effects on work ability, job strain and quality of life of monitoring depression using a self-assessment instrument in recurrent general practitioner consultations: A randomized controlled study.

    Science.gov (United States)

    Petersson, E-L; Wikberg, C; Westman, J; Ariai, N; Nejati, S; Björkelund, C

    2018-05-01

    Depression reduces individuals' function and work ability and is associated with both frequent and long-term sickness absence. Investigate if monitoring of depression course using a self-assessment instrument in recurrent general practitioner (GP) consultations leads to improved work ability, decreased job strain, and quality of life among primary care patients. Primary care patients n = 183, who worked. In addition to regular treatment (control group), intervention patients received evaluation and monitoring and used the MADRS-S depression scale during GP visit at baseline and at visits 4, 8, and 12 weeks. Work ability, quality of life and job strain were outcome measures. Depression symptoms decreased in all patients. Significantly steeper increase of WAI at 3 months in the intervention group. Social support was perceived high in a significantly higher frequency in intervention group compared to control group. Monitoring of depression course using a self-assessment instrument in recurrent GP consultations seems to lead to improved self-assessed work ability and increased high social support, but not to reduced job strain or increased quality of life compared to TAU. Future studies concerning rehabilitative efforts that seek to influence work ability probably also should include more active interventions at the workplace.

  6. Development of the gaharu oil quality control

    International Nuclear Information System (INIS)

    Chong Saw Peng; Mohd Fajri Osman; Shyful Azizi Abdul Rahman; Khairuddin Abdul Rahim; Mat Rasol Awang

    2010-01-01

    Gaharu (Agar wood) is a secondary metabolite produces by the Aquilaria spp. and accumulates in the plant cell in oleoresin form. The essential oil known as gaharu oil can be extracted from this oleoresin gaharu via varies extraction method such as the water distillation, solvent extraction, pressurize extraction and etc. The gaharu oil extracted through different methods will give different fragrances. Besides, different source of materials will also give different in chemical profiles. In gaharu oil trading market, most of the buyers request quality assurance from the gaharu oil manufacturer to assure the gaharu oil purchased meets their standard requirement. Since there is a demand on gaharu oil quality assurance then it become a need to develop the gaharu oil quality control method in order to have a standard quality control of gaharu oil presented in a certificate of analysis and verified by laboratory. (author)

  7. Quality control in diagnostic radiology - patient dosimetry

    Energy Technology Data Exchange (ETDEWEB)

    Prlic, I; Radalj, Z; Brumen, V; Cerovac, H [Institute for Medical Research and Occupational Health, Laboratory for Radiation Protection and Dosimetry, Zagreb (Croatia); Gladic, J [Institute for Physics, Laboratory for Solid State Physics, Zagreb (Croatia); Tercek, V [Clinical Hospital Sisters of Mercy, Health Physics Department, Zagreb (Croatia)

    1997-12-31

    In order to establish the Quality Criteria for diagnostic radiographic images in the radiology departments in Republic of Croatia we have started the several Quality Control projects on the field. The measurements are performed according to some methodology recommendations in our law but the methodology, measurement principles, measurement equipment, phantoms, measurable parameters for the good use by radiographers, statistical and numerical evaluation, dosimetric philosophy etc. where first recognized as a private/or group hazard of each person involved in the procedure of evaluation of diagnostic radiology images/diagnosis. The important quality elements of the imaging process are: the diagnostic quality of the radiographic image, the radiation dose to the patient and the choice of the radiographic technique. This depends on the x-ray unit (tube) radiation quality, image processing quality and final image evaluation quality. In this paper we will show how the Quality Control measurements can be easily connected to the dose delivered to the patient for the known diagnostic procedure and how this can be used by radiographers in their daily work. The reproducibility of the x-ray generator was checked before the service calibration and after the service calibration. The table of kV dependence and output dose per mAs was calculated and the ESD (entrance surface dose) was measured/calculated for the specific diagnostic procedure. After the phantom calculation were made and the dose prediction for the given procedure was done, measurements were done on the patients (digital dosemeters, TLD and film dosemeter combinations). We are claiming that there is no need to measure each patient if the proper Quality Control measurements are done and the proper table of ESD for each particular x-ray tube in diagnostic departments is calculated for the radiographers daily use. (author). 1 example, 1 fig., 13 refs.

  8. End-tidal carbon dioxide output in manual cardiopulmonary resuscitation versus active compression-decompression device during prehospital quality controlled resuscitation: a case series study.

    Science.gov (United States)

    Setälä, Piritta Anniina; Virkkunen, Ilkka Tapani; Kämäräinen, Antti Jaakko; Huhtala, Heini Sisko Annamari; Virta, Janne Severi; Yli-Hankala, Arvi Mikael; Hoppu, Sanna Elisa

    2018-05-16

    Active compression-decompression (ACD) devices have enhanced end-tidal carbon dioxide (ETCO 2 ) output in experimental cardiopulmonary resuscitation (CPR) studies. However, the results in out-of-hospital cardiac arrest (OHCA) patients have shown inconsistent outcomes, and earlier studies lacked quality control of CPR attempts. We compared manual CPR with ACD-CPR by measuring ETCO 2 output using an audiovisual feedback defibrillator to ensure continuous high quality resuscitation attempts. 10 witnessed OHCAs were resuscitated, rotating a 2 min cycle with manual CPR and a 2 min cycle of ACD-CPR. Patients were intubated and the ventilation rate was held constant during CPR. CPR quality parameters and ETCO 2 values were collected continuously with the defibrillator. Differences in ETCO 2 output between manual CPR and ACD-CPR were analysed using a linear mixed model where ETCO 2 output produced by a summary of the 2 min cycles was included as the dependent variable, the patient as a random factor and method as a fixed effect. These comparisons were made within each OHCA case to minimise confounding factors between the cases. Mean length of the CPR episodes was 37 (SD 8) min. Mean compression depth was 76 (SD 1.3) mm versus 71 (SD1.0) mm, and mean compression rate was 100 per min (SD 6.7) versus 105 per min (SD 4.9) between ACD-CPR and manual CPR, respectively. For ETCO 2 output, the interaction between the method and the patient was significant (P<0.001). ETCO 2 output was higher with manual CPR in 6 of the 10 cases. This study suggests that quality controlled ACD-CPR is not superior to quality controlled manual CPR when ETCO 2 is used as a quantitative measure of CPR effectiveness. NCT00951704; Results. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  9. Effects of yoga versus hydrotherapy training on health-related quality of life and exercise capacity in patients with heart failure: A randomized controlled study.

    Science.gov (United States)

    Hägglund, Ewa; Hagerman, Inger; Dencker, Kerstin; Strömberg, Anna

    2017-06-01

    The aims of this study were to determine whether yoga and hydrotherapy training had an equal effect on the health-related quality of life in patients with heart failure and to compare the effects on exercise capacity, clinical outcomes, and symptoms of anxiety and depression between and within the two groups. The design was a randomized controlled non-inferiority study. A total of 40 patients, 30% women (mean±SD age 64.9±8.9 years) with heart failure were randomized to an intervention of 12 weeks, either performing yoga or training with hydrotherapy for 45-60 minutes twice a week. Evaluation at baseline and after 12 weeks included self-reported health-related quality of life, a six-minute walk test, a sit-to-stand test, clinical variables, and symptoms of anxiety and depression. Yoga and hydrotherapy had an equal impact on quality of life, exercise capacity, clinical outcomes, and symptoms of anxiety and depression. Within both groups, exercise capacity significantly improved (hydrotherapy p=0.02; yoga p=0.008) and symptoms of anxiety decreased (hydrotherapy p=0.03; yoga p=0.01). Patients in the yoga group significantly improved their health as rated by EQ-VAS ( p=0.004) and disease-specific quality of life in the domains symptom frequency ( p=0.03), self-efficacy ( p=0.01), clinical summary as a combined measure of symptoms and social factors ( p=0.05), and overall summary score ( p=0.04). Symptoms of depression were decreased in this group ( p=0.005). In the hydrotherapy group, lower limb muscle strength improved significantly ( p=0.01). Yoga may be an alternative or complementary option to established forms of exercise training such as hydrotherapy for improvement in health-related quality of life and may decrease depressive symptoms in patients with heart failure.

  10. Frontiers in statistical quality control 11

    CERN Document Server

    Schmid, Wolfgang

    2015-01-01

    The main focus of this edited volume is on three major areas of statistical quality control: statistical process control (SPC), acceptance sampling and design of experiments. The majority of the papers deal with statistical process control, while acceptance sampling and design of experiments are also treated to a lesser extent. The book is organized into four thematic parts, with Part I addressing statistical process control. Part II is devoted to acceptance sampling. Part III covers the design of experiments, while Part IV discusses related fields. The twenty-three papers in this volume stem from The 11th International Workshop on Intelligent Statistical Quality Control, which was held in Sydney, Australia from August 20 to August 23, 2013. The event was hosted by Professor Ross Sparks, CSIRO Mathematics, Informatics and Statistics, North Ryde, Australia and was jointly organized by Professors S. Knoth, W. Schmid and Ross Sparks. The papers presented here were carefully selected and reviewed by the scientifi...

  11. Quality control procedures in positron tomography

    International Nuclear Information System (INIS)

    Spinks, T.; Jones, T.; Heather, J.; Gilardi, M.

    1989-01-01

    The derivation of physiological parameters in positron tomography relies on accurate calibration of the tomograph. Normally, the calibration relates image pixel count density to the count rate from an external blood counter per unit activity concentration in each device. The quality control of the latter is simple and relies on detector stability assessed by measurement of a standard source of similar geometry to a blood sample. The quality control of the tomographic data depends on (i) detector stability, (ii) uniformity of calibration and normalisation sources and (iii) reproducibility of the attenuation correction procedure. A quality control procedure has been developed for an 8 detector ring (15 transaxial plane) tomograph in which detector response is assessed by acquiring data from retractable transmission ring sources. These are scanned daily and a print out of detector efficiencies is produced as well as changes from a given data. This provides the raw data from which decisions on recalibration or renormalisation are made. (orig.)

  12. Quality control of the activity meter

    International Nuclear Information System (INIS)

    Rodrigues, Marlon da Silva Brandão; Sá, Lídia Vasconcelos de

    2017-01-01

    Objective: To carry out a comparative analysis of national and international standards regarding the quality control of the activity meter used in Nuclear Medicine Services in Brazil. Material and methods: Quality control protocols from the International Atomic Energy Agency (IAEA), American Association of Physicists in Medicine (AAPM) and International Electrotechnical Commission (IEC) were pointed out and compared with requirements from both regulatory Brazilian agencies, National Surveillance Agency (ANVISA) and National Nuclear Energy Commission (CNEN). Results: The daily routine tests recommended by the regulatory agencies do not have significant differences; in contrast the tests with higher periodicities like (accuracy, linearity and precision) have differences discrepant. Conclusion: In view of the comparative analysis carried out, it is suggested that the national recommendations for the quality control tests of the activity meter should be checked and evaluated, with emphasis on the semiannual and annual periodicity tests. (author)

  13. Protein quality control in the nucleus

    DEFF Research Database (Denmark)

    Nielsen, Sofie V.; Poulsen, Esben Guldahl; Rebula, Caio A.

    2014-01-01

    to aggregate, cells have evolved several elaborate quality control systems to deal with these potentially toxic proteins. First, various molecular chaperones will seize the misfolded protein and either attempt to refold the protein or target it for degradation via the ubiquitin-proteasome system...... to be particularly active in protein quality control. Thus, specific ubiquitin-protein ligases located in the nucleus, target not only misfolded nuclear proteins, but also various misfolded cytosolic proteins which are transported to the nucleus prior to their degradation. In comparison, much less is known about...... these mechanisms in mammalian cells. Here we highlight recent advances in our understanding of nuclear protein quality control, in particular regarding substrate recognition and proteasomal degradation....

  14. Effectiveness of the HuCare Quality Improvement Strategy on health-related quality of life in patients with cancer: study protocol of a stepped-wedge cluster randomised controlled trial (HuCare2 study).

    Science.gov (United States)

    Caminiti, Caterina; Iezzi, Elisa; Passalacqua, Rodolfo

    2017-10-06

    Our group previously demonstrated the feasibility of the HuCare Quality Improvement Strategy (HQIS), aimed at integrating into practice six psychosocial interventions recommended by international guidelines. This trial will assess whether the introduction of the strategy in oncology wards improves patient's health-related quality of life (HRQoL). Multicentre, incomplete stepped-wedge cluster randomised controlled trial, conducted in three clusters of five centres each, in three equally spaced time epochs. The study also includes an initial epoch when none of the centres are exposed to the intervention, and a final epoch when all centres will have implemented the strategy. The intervention is applied at a cluster level, and assessed at an individual level with cross-sectional model. A total of 720 patients who received a cancer diagnosis in the previous 2 months and about to start medical treatment will be enrolled. The primary aim is to evaluate the effectiveness of the HQIS versus standard care in terms of improvement of at least one of two domains (emotional and social functions) of HRQoL using the EORTC QLQ-C30 (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 items) questionnaire, at baseline and at 3 months. This outcome was chosen because patients with cancer generally exhibit low HRQoL, particularly at certain stages of care, and because it allows to assess the strategy's impact as perceived by patients themselves. The HQIS comprises three phases: (1) clinician training-to improve communication-relational skills and instruct on the project; (2) centre support-four on-site visits by experts of the project team, aimed to boost motivation, help with context analysis and identification of solutions; (3) implementation of Evidence-Based Medicine (EBM) recommendations at the centre. Ethics committee review approval has been obtained from the Ethics Committee of Parma. Results will be disseminated at conferences, and

  15. Physical and Mental Quality of Life (QOL) in Chronic Pancreatitis(CP): A Case-Control Study from the NAPS2 cohort

    Science.gov (United States)

    Amann, Stephen T.; Yadav, Dhiraj; Barmada, M. Micheal; O’Connell, Michael; Kennard, Elizabeth D.; Anderson, Michelle; Baillie, John; Sherman, Stuart; Romagnuolo, Joseph; Hawes, Robert H.; AlKaade, Samer; Brand, Randall E.; Lewis, Michele D.; Gardner, Timothy B.; Gelrud, Andres; Money, Mary E.; Banks, Peter A.; Slivka, Adam; Whitcomb, David C

    2012-01-01

    Objectives Define the Quality of Life (QOL) in chronic pancreatitis (CP) subjects Methods We studied 443 well phenotyped CP subjects and 611 controls prospectively enrolled from 20 US centers between 2000–2006 in the North American Pancreatitis Study 2 (NAPS2). Responses to the SF-12 questionnaire were used to calculate the Mental (MCS) and Physical component summary scores (PCS) with norm based scoring (normal ≥50). QOL in CP subjects was compared with controls after controlling for demographic factors, drinking history, smoking and medical conditions. QOL in CP was also compared with known scores for several chronic conditions. Results Both PCS (38±11.5 vs. 52±9.4) and MCS (44±11.5 vs. 51±9.2) were significantly lower in CP compared with controls (p<0.001). On multivariable analyses, compared to controls, a profound decrease in physical QOL (PCS 12.02 points lower) and a clinically significant decrease in mental QOL (MCS 4.24 points lower) was seen due to CP. QOL in CP was similar to (heart, kidney, liver, lung disease) or worse than (non-skin cancers, diabetes mellitus, hypertension, rheumatoid arthritis) other chronic conditions. Conclusions The impact of CP on QOL appears substantial. The QOL in CP subjects appears to be worse or similar to the QOL of many other chronic conditions. PMID:23357924

  16. A quality control program for radiation sources

    International Nuclear Information System (INIS)

    Almeida, C.E. de; Sibata, C.H.; Cecatti, E.R.; Kawakami, N.S.; Alexandre, A.C.; Chiavegatti Junior, M.

    1982-01-01

    An extensive quality control program was established covering the following areas: physical parameters of the therapeutical machines, dosimetric standards, preventive maintenance of radiation sources and measuring instruments. A critical evaluation of this program was done after two years (1977-1979) of routine application and the results will be presented. The fluctuation on physical parameters strongly supports the efforts and cost of a quality control program. This program has certainly improved the accuracy required on the delivery of the prescribed dose for radiotherapy treatment. (Author) [pt

  17. Quality control of nuclear medicine instruments 1991

    International Nuclear Information System (INIS)

    1991-05-01

    This document gives detailed guidance on the quality control of various instruments used in nuclear medicine. A first preliminary document was drawn up in 1979. A revised and extended version, incorporating recommended procedures, test schedules and protocols was prepared in 1982. The first edition of ''Quality Control of Nuclear Medicine Instruments'', IAEA-TECDOC-317, was printed in late 1984. Recent advances in the field of nuclear medicine imaging made it necessary to add a chapter on Camera-Computer Systems and another on SPECT Systems. Figs and tabs

  18. Quality control of nuclear medicine instruments, 1991

    International Nuclear Information System (INIS)

    1996-12-01

    This document gives detailed guidance on the quality control of various instruments used in nuclear medicine. A first preliminary document was drawn up in 1979. A revised and extended version, incorporating recommended procedures, test schedules and protocols was prepared in 1982. The first edition of 'Quality Control of Nuclear Medicine Instruments', IAEA-TECDOC-317, was printed in late 1984. Recent advances in the field of nuclear medicine imaging made it necessary to add a chapter on Camera-Computer Systems and another on SPECT Systems

  19. Statistical quality control a loss minimization approach

    CERN Document Server

    Trietsch, Dan

    1999-01-01

    While many books on quality espouse the Taguchi loss function, they do not examine its impact on statistical quality control (SQC). But using the Taguchi loss function sheds new light on questions relating to SQC and calls for some changes. This book covers SQC in a way that conforms with the need to minimize loss. Subjects often not covered elsewhere include: (i) measurements, (ii) determining how many points to sample to obtain reliable control charts (for which purpose a new graphic tool, diffidence charts, is introduced), (iii) the connection between process capability and tolerances, (iv)

  20. Technical quality control - constancy controls for digital mammography systems

    International Nuclear Information System (INIS)

    Pedersen, K.; Landmark, I.D.; Bredholt, K.; Hauge, I.H.R.

    2009-04-01

    To ensure the quality of mammographic images, so-called constancy control tests are performed frequently. The report contains a programme for constancy control of digital mammography systems, encompassing the mammography unit, computed radiography (CR) systems, viewing conditions and displays, printers, and procedures for data collection for patient dose calculations. (Author)

  1. Academic Quality Control in Nigerian Universities: Exploring Lecturers' Perceptions

    Science.gov (United States)

    Obiekezie, E. O.; Ejemot-Nwadiaro, R. I.; Essien, M. I.; Timothy, A. Essien

    2014-01-01

    The level of job performance, international comparability and competitiveness of Nigerian university graduates are burning issues. Consequently, the academic quality of Nigerian universities has come under severe criticism. Since university lecturers are key players in quality control in universities, this study explored their perceptions of…

  2. Quality control and characterization of bentonite materials

    International Nuclear Information System (INIS)

    Kiviranta, L.; Kumpulainen, S.

    2011-12-01

    . Thus, in a certain extent, index tests can be used to determine the smectite content indicatively for quality control purposes. Previously set acceptance testing requirement limits for swelling index, liquid limit and CEC should be reconsidered, since Ca-bentonite tested in this study did not fulfill the requirement for swelling index, the previously set liquid limit requirement value was way below the values measured in this study, and because the previously set CEC requirement limits were based on a technique that needed different requirement limits for Na- and Ca-bentonites, on contrary to the method used in this study.(orig.)

  3. Impact of the Mobile HealthPROMISE Platform on the Quality of Care and Quality of Life in Patients With Inflammatory Bowel Disease: Study Protocol of a Pragmatic Randomized Controlled Trial

    Science.gov (United States)

    Khan, Sameer; Rogers, Jason D; Otobo, Emamuzo; Patel, Nishant P; Ullman, Thomas; Colombel, Jean Fred; Moore, Shirley; Sands, Bruce E

    2015-01-01

    Background Inflammatory bowel disease (IBD) is a chronic condition of the bowel that affects over 1 million people in the United States. The recurring nature of disease makes IBD patients ideal candidates for patient-engaged care that is centered on enhanced self-management and improved doctor-patient communication. In IBD, optimal approaches to management vary for patients with different phenotypes and extent of disease and past surgical history. Hence, a single quality metric cannot define a heterogeneous disease such as IBD, unlike hypertension and diabetes. A more comprehensive assessment may be provided by complementing traditional quality metrics with measures of the patient’s quality of life (QOL) through an application like HealthPROMISE. Objective The objective of this pragmatic randomized controlled trial is to determine the impact of the HealthPROMISE app in improving outcomes (quality of care [QOC], QOL, patient adherence, disease control, and resource utilization) as compared to a patient education app. Our hypothesis is that a patient-centric self-monitoring and collaborative decision support platform will lead to sustainable improvement in overall QOL for IBD patients. Methods Participants will be recruited during face-to-face visits and randomized to either an interventional (ie, HealthPROMISE) or control (ie, education app). Patients in the HealthPROMISE arm will be able to update their information and receive disease summary, quality metrics, and a graph showing the trend of QOL (SIBDQ) scores and resource utilization over time. Providers will use the data for collaborative decision making and quality improvement interventions at the point of care. Patients in the control arm will enter data at baseline, during office visits, and at the end of the study but will not receive any decision support (trend of QOL, alert, or dashboard views). Results Enrollment in the trial will be starting in first quarter of 2015. It is intended that up to 300

  4. Control cards as a statistical quality control resource

    Directory of Open Access Journals (Sweden)

    Aleksandar Živan Drenovac

    2013-02-01

    Full Text Available Normal 0 false false false MicrosoftInternetExplorer4 This paper proves that applying of statistical methods can significantly contribute increasing of products and services quality, as well as increasing of institutions rating. Determining of optimal, apropos anticipatory and limitary values, is based on sample`s statistical analyze. Control cards represent very confident instrument, which is simple for use and efficient for control of process, by which process is maintained in set borders. Thus, control cards can be applied in quality control of procesess of weapons and military equipment production, maintenance of technical systems, as well as for seting of standards and increasing of quality level for many other activities.

  5. A Comparison of Power Quality Controllers

    Directory of Open Access Journals (Sweden)

    Petr Černek

    2012-01-01

    Full Text Available This paper focuses on certain types of FACTS (Flexibile AC Transmission System controllers, which can be used for improving the power quality at the point of connection with the power network. It focuses on types of controllers that are suitable for use in large buildings, rather than in transmission networks. The goal is to compare the features of the controllers in specific tasks, and to clarify which solution is best for a specific purpose. It is in some cases better and cheaper to use a combination of controllers than a single controller. The paper also presents the features of a shunt active harmonic compensator, which is a very modern power quality controller that can be used in many cases, or in combination with other controllers. The comparison was made using a matrix diagram that, resulted from mind mapsand other analysis tools. The paper should help engineers to choose the best solution for improving the power quality in a specific power network at distribution level.

  6. Current status of quality evaluation of nursing care through director review and reflection from the Nursing Quality Control Centers

    OpenAIRE

    Duan, Xia; Shi, Yan

    2014-01-01

    Background: The quality evaluation of nursing care is a key link in medical quality management. It is important and worth studying for the nursing supervisors to know the disadvantages during the process of quality evaluation of nursing care and then to improve the whole nursing quality. This study was to provide director insight on the current status of quality evaluation of nursing care from Nursing Quality Control Centers (NQCCs). Material and Methods: This qualitative study used a sample ...

  7. Quality control/quality assurance testing for joint density and segregation of asphalt mixtures.

    Science.gov (United States)

    2013-04-01

    Longitudinal joint quality control/assurance is essential to the successful performance of asphalt pavements and it has received considerable amount of attention in recent years. The purpose of the study is to evaluate the level of compaction at the ...

  8. A Feasibility Study of Moxibustion for Treating Anorexia and Improving Quality of Life in Patients With Metastatic Cancer: A Randomized Sham-Controlled Trial.

    Science.gov (United States)

    Jeon, Ju-Hyun; Cho, Chong-Kwan; Park, So-Jung; Kang, Hwi-Joong; Kim, Kyungmin; Jung, In-Chul; Kim, Young-Il; Lee, Suk-Hoon; Yoo, Hwa-Seung

    2017-03-01

    The aim of this study was to determine the feasibility, acceptability, and safety of using moxibustion for treating anorexia and improving quality of life in patients with metastatic cancer. We conducted a randomized sham-controlled trial of moxibustion. Sixteen patients with metastatic cancer were recruited from Daejeon, South Korea. The patients were randomly placed into a true or a sham moxibustion group and received 10 true or sham moxibustion treatments administered to the abdomen (CV12, CV8, CV4) and legs (ST36) over a 2-week period. Outcome measures included interest in participating in the trial, identification of successful recruitment strategies, the appropriateness of eligibility criteria, and compliance with the treatment plan (ie, attendance at treatment sessions). Clinical outcomes included results of the Functional Assessment of Anorexia/Cachexia Therapy (FAACT), answers on the European Organization for Research and Treatment of Cancer 30-item core quality of life (EORTC QLQ-C30) questionnaires, scores on the visual analogue scale (VAS), and the results from blood tests and a safety evaluation. Moxibustion was an acceptable intervention in patients with metastatic cancer. Compliance with the treatment protocol was high, with 11 patients completing all 10 treatments. No serious adverse events related to moxibustion occurred, but 4 patients in the true moxibustion group reported mild rubefaction, which disappeared in a few hours. This study suggests that moxibustion may be safely used to treat anorexia and improve quality of life in patients with metastatic cancer. However, further research is needed to confirm this result.

  9. A real-time approach toward the chemical quality control of rock material (Case study: Gravel mines in Semnan, Iran

    Directory of Open Access Journals (Sweden)

    Behzad Tokhmechi

    2016-06-01

    Full Text Available The quality of concrete is highly dependent on the characteristics of its aggregate, such as the size, minerals, and their chemical properties. Even a small amount of impurities, such as hydrated sulfates, chlorine (salt, and acidic pH of the rock material, can adversely affect the quality of the concrete. Thus, many national codes and standards are developed for testing, selecting, and employing the rock materials in concrete. For instance, Iranian standards 446, 449, 1702, 4978, 4984, 7174, and 86721 are currently serving this purpose. In the present research, a new real-time system was developed in order to replace the customary chemical analysis and size distribution tests. 20 samples were taken from two mines, selected by the Building Material Committee of Semnan Province, in order to determine the dissolved chlorine and sulfate, pH, density as well as size distribution. The new system is constituted of hydraulic jacks and a reservoir, designed to take samples from the conveyer in given time intervals. The samples were washed with distilled water and real-time analyses of dissolved chlorine and pH were performed. The results showed 85% agreement with the results from laboratory analyses. The correct classification rate (CCR was 92% for 13 samples.

  10. Regional intercomparison for quality control of radioassays used in thyroid studies. Part of a coordinated programme on quality control of techniques in in-vitro assay of thyroid related hormones

    International Nuclear Information System (INIS)

    Fiori, A.M.

    1983-01-01

    The project dealt with serious variabilities of the results of the radioimmunoassay (RIA) technique presented by different laboratories. The educational purpose of the project was to get users of RIA methods to become aware of the necessity of rigorous internal and external quality control practice. Two hundred and four sera aliquots were distributed among the participants of the project. The first batch consisted of 60 tubes, which were frozen. All others were lyophilized. The first batch consisted of pooled sera with low and high concentrations of T3 and T4, and unknown concentration of TSH. The second and third batches consisted of aliquots of normal sera for T3, T4 and TSH. The fourth batch consisted of coded aliquots of high and low concentrations of T3, T4 and TSH. All data from the participants (laboratories represented the Southern Region of Brazil and Uruguay) were collected and analyzed statistically; a special computer programme was developed for that purpose. Quarterly reports were sent to each laboratory with comments and suggestions aiming at the improvement of the performance of the laboratory in question. A high degree of irregularity in the first reporting results was observed. Individual values for T3 ranged from 0 to 176 nanog/dl with a coefficient of variation of 36.5%. Values for T4 ranged from 3.99 to 7.17 microg/dl with a coefficient of variation of 9.5%. Values for TSH ranged from 0 to 6.71 microU/dl with a coefficient of variation of 75.6%. The variability of results in different laboratories is probably caused by several reasons such as different kit's manufacturers, different standards, different antibody preparation, different separation methods. The educational part of the project seems to be rather successful. The performance of laboratories improved with time. This also demonstrates the need for intra-laboratory quality control

  11. Emergency management of patients with ST-segment elevation myocardial infarction in Eastern Austria: a descriptive quality control study.

    Science.gov (United States)

    Trimmel, Helmut; Bayer, Thomas; Schreiber, Wolfgang; Voelckel, Wolfgang G; Fiedler, Lukas

    2018-05-09

    Myocardial infarction is a time-critical condition and its outcome is determined by appropriate emergency care. Thus we assessed the efficacy of a supra-regional ST-segment elevation myocardial infarction (STEMI) network in Easternern Austria. The Eastern Austrian STEMI network serves a population of approx. 766.000 inhabitants within a region of 4186 km 2 . Established in 2007, it now comprises 20 pre-hospital emergency medical service (EMS) units (10 of these physician-staffed), 4 hospitals and 3 cardiac intervention centres. Treatment guidelines were updated in 2012 and documentation within a web-based STEMI registry became mandatory. For this retrospective qualitative control study, data from February 2012-April 2015 was assessed. A total of 416 STEMI cases were documented, and 99% were identified by EMS within 6 (4.0-8.0) minutes after arrival. Median time loss between onset of pain and EMS call was 54 (20-135) minutes; response, pre-hospital and door-to-balloon times were 14 (10-20), 46 (37-59) and 45 (32-66) minutes, respectively. When general practitioners were involved, time between onset of pain and balloon inflation significantly increased from 180 (135-254) to 218 (155-348) minutes (p < .001). A pre-hospital time < 30 min was achieved in 25.8% of all patients during the day vs. 11.6% during the night (p < .001). Three hundred forty-five patients (83%) were subjected to primary percutaneous coronary intervention (PPCI), and 6.5% were thrombolysed by EMS. Pre-hospital complication rate was 18% (witnessed cardiac arrest 7%, threatening arrhythmias 6%, cardiogenic shock 5%). Twenty-four hours and hospital mortality rate were 1.2 and 2.8%, respectively. Optimal patient care and subsequently outcome of STEMI is strongly determined by a short patient-decision time to call EMS and by the first medical contact to balloon time (FMCBT). Supra-regional networks are key in order to increase the efficacy and efficiency of health care. The goal of 120

  12. Functional Fitness and Self-Reported Quality of Life of Older Women Diagnosed with Knee Osteoarthrosis: A Cross-Sectional Case Control Study

    Directory of Open Access Journals (Sweden)

    Paula Andréa Malveira Cavalcante

    2015-01-01

    Full Text Available Aim. Utilizing a cross-sectional case control design, the aim of this study was to evaluate the functional fitness and self-reported quality of life differences in older people diagnosed with knee osteoarthrosis (O who participated in health promotion groups. Methods. Ninety older women were distributed into two groups: control without O of the knee (C, n=40 and a group diagnosed with primary and secondary knee O with grade II or higher, with definite osteophytes (OA, n=50. Functional fitness was evaluated by specific tests, and the time spent in physical activity and quality of life was evaluated by the IPAQ and WHOQOL (distributed in four domains: physical: P, psychological: PS, social: S, and environmental: E domain questionnaires. Results. No differences were found between ages of groups (C: 66±7; OA: 67±9; years. The values of the chair stand test (rep in the OA (13±5 group were different when compared to C group (22±5. For the 6-minute walk test (meters, the values obtained for the C (635±142 were higher (P<0.01 than the OA (297±143 group. The time spent in physical activity (min was greater (P<0.001 in the control (220±12 group compared to OA (100±10 group. Higher values (P<0.001 in all domains were found in the C (P: 69±16, PS: 72±17, S: 67±15, E: 70±15 group compared to OA (P: 48±7, PS: 43±8, S: 53±13, E: 47±14 group. Conclusion. Our data suggests that knee O, in older women, can promote a decline in time spent performing physical activity and functional fitness with decline in quality of life with an increase in sitting time.

  13. Effect of a multidisciplinary supportive program for family caregivers of patients with heart failure on caregiver burden, quality of life, and depression: A randomized controlled study.

    Science.gov (United States)

    Hu, Xiaolin; Dolansky, Mary A; Su, Yonglin; Hu, Xiuying; Qu, Moying; Zhou, Lingjuan

    2016-10-01

    Caregivers of patients with heart failure experience burden and negative health outcomes. Adequate support for family caregivers improves their well-being and the quality of care provided to the patients. However, little is known about the benefits of interventions for caregivers of patients with heart failure in China. To test the effects of a multidisciplinary supportive program for family caregivers on caregiver burden, quality of life, and depression. A randomized controlled design with repeated measures was used in this study. A total of 118 participants were randomized into experimental (n=59) and control groups (n=59) from May to December 2014 in one hospital in Chengdu, People's Republic of China. Participants in the experimental group received a 3-month multidisciplinary supportive program, consisting of three 60-min sessions of group classes, three 30-min peer support groups, and regular telephone follow-ups and consultations, while participants in the control group received usual care only. Outcomes were caregiver burden, quality of life, and depression. Data were collected at baseline, post-test (3 months after discharge), and 3 months after post-test (6 months after discharge). The repeated measures analysis of variance was used to examine the effects of groups, changes over time, and time-group interaction on outcome variables. There were significant improvements in caregiver burden, mental health, and depression after post-test and 3 months after post-test in the experimental group. However, there was no significant improvement in caregivers' physical health at either 3 or 6 months following discharge. A multidisciplinary supportive program for caregivers of heart failure patients had positive effects and provides a unique perspective of an intervention considering Chinese culture and customs. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. The impact of type 2 diabetes on health related quality of life in Bangladesh: results from a matched study comparing treated cases with non-diabetic controls.

    Science.gov (United States)

    Safita, Novie; Islam, Sheikh Mohammed Shariful; Chow, Clara K; Niessen, Louis; Lechner, Andreas; Holle, Rolf; Laxy, Michael

    2016-09-13

    Little is known about the association between diabetes and health related quality of life (HRQL) in lower-middle income countries. This study aimed to investigate HRQL among individuals with and without diabetes in Bangladesh. The analysis is based on data of a case-control study, including 591 patients with type 2 diabetes (cases) who attended an outpatient unit of a hospital in Dhaka and 591 age -and sex-matched individuals without diabetes (controls). Information about socio-demographic characteristics, health conditions, and HRQL were assessed in a structured interview. HRQL was measured with the EuroQol (EQ) visual analogue scale (VAS) and the EQ five-dimensional (5D) descriptive system. The association between diabetes status and quality of life was examined using multiple linear and logistic regression models. Mean EQ-VAS score of patients with diabetes was 11.5 points lower (95 %-CI: -13.5, -9.6) compared to controls without diabetes. Patients with diabetes were more likely to report problems in all EQ-5D dimensions than controls, with the largest effect observed in the dimensions 'self-care' (OR = 5.9; 95 %-CI: 2.9, 11.8) and 'mobility' (OR = 4.5; 95 %-CI: 3.0, -6.6). In patients with diabetes, male gender, high education, and high-income were associated with higher VAS score and diabetes duration and foot ulcer associated with lower VAS scores. Other diabetes-related complications were not significantly associated with HRQL. Our findings suggest that the impact of diabetes on HRQL in the Bangladeshi population is much higher than what is known from western populations and that unlike in western populations comorbidities/complications are not the driving factor for this effect.

  15. Study of factors controlling exposure dose and image quality of C-arm in operation room according to detector size of it (Mainly L-Spine AP study)

    Energy Technology Data Exchange (ETDEWEB)

    Chui, Sung Hyun; Jo, Hwang Woo [Dept. of Radiology, Kyung Hee University Hospital at Gangdong, Seoul (Korea, Republic of); Chun, Woon Kwan; Song, Ha Jin [Dept. of Nuclear Engineering, Chosun University, Gwangju (Korea, Republic of); Dong, Kyung Rae [Dept. of Radiological Technology, Gwangju Health University, Gwangju (Korea, Republic of); Choi, Eun Jin [Dept. of Public Health and Medicine, Dongshin University, Naju (Korea, Republic of)

    2015-02-15

    Time of operation has been reduced and accuracy of operation has been improved since C-arm, which offer real-time image of patient, was introduced in operation room. However, because of the contamination of patient, C-arm could not be used more appropriately. Therefore, this study is to know factors of controlling exposure dose, image quality and the exposed dose of health professional in operation room. Height of Wilson frame (bed for operation) was fixed at 130 cm. Then, Model 76-2 Phantom, which was set by assembling manual of Fluke Company, was set on the bed. Head/Spine Fluoroscopy AEC mode was set for exposure condition. According to detector size of C-arm, the absorbed dose per min was measured in the 7 steps OFD (cm) from 10 cm to 40 cm (10, 15, 20, 25, 30, 35, 40 cm). In each step of OFD, the absorbed dose per min of same diameter of collimation was measured. Moreover, using Nero MAX Model 8000, exposure dose per min was measured according to 3 step of distance from detector (20 cm, 60 cm, 100 cm). Finally, resolution was measured by CDRH Disc Phantom and magnification of each OFD was measured by aluminum stick bar. According to detector size of C-arm, difference of absorbed dose shows that the dose of 20 cm OFD is 1.750 times higher than the dose of 40 cm OFD. It means that the C-arm, which has smaller size of detector, shows the bigger difference of absorbed dose per min (p<0.05). In the difference of absorbed dose in the same step of OFD (from 20 cm to 40 cm), the absorbed dose of 9 inch detect or C-arm was 1.370 times higher than 12 inch' s (p<0.05). When OFD was set to 20 cm OFD, the absorbed dose of non-collimation case was approximately 0.816 times lower than the absorbed dose of collimation cases (p<0.05). When the distance was 20 cm from detector, exposed does includes first-ray and scatter-ray. When the distance was 60 cm and 100 cm from detector, exposed does includes just scatter-ray. So, there was the 2.200 times difference of absorbed

  16. Functional aspects of treatment with implant-supported single crowns: a quality control study in subjects with tooth agenesis

    DEFF Research Database (Denmark)

    Goshima, Kenichi; Lexner, Michala O; Thomsen, Carsten Eckhart

    2010-01-01

    -Related Quality of Life (OHRQoL) in subjects with tooth agenesis. MATERIAL AND METHODS: In nine females and nine males (32 + or - 10 years) with agenesis treated with one to four ISSC (68% in the premolar region), the treatment effect and masticatory function were assessed. The evaluation was performed first...... after implant placement shortly before crown cementation, and again 1 month after cementation. It consisted of questionnaires [including Oral Health Impact Profile (OHIP-49)] and functional examination with plastic strips, the Dental Prescale Film and the Occluzer system, Xylitol color-changeable gum...... with ISSCs in subjects with tooth agenesis significantly increased masticatory function subjectively and clinically as well as OHRQoL. However, as the functional parameters before replacement of the teeth corresponded to values in subjects with complete dentitions, the functional importance of the increase...

  17. Data Organization for Quality Control Test

    International Nuclear Information System (INIS)

    Yahaya Talib; Glam Hadzir Patai Mohamad; Wan Hamirul Bahrin Wan Kamal

    2011-01-01

    Test data and results for quality control of Mo-99/ Tc-99m generator shall be organized properly. A computer program was developed using Visual Basic 6.0 to process test data, store data and results to specific folder, generate test reports and certificates. Its performance has been evaluated and tested. (author)

  18. Materials, methods and quality control, ch. 3

    International Nuclear Information System (INIS)

    Vader, H.L.

    1978-01-01

    A description of the chemical reagents, the 125 I-labelled angiotensin I, the antiserum and the standards is given. A modified measuring method with the New England Nuclear kit for angiotensin I radioimmunoassay is presented as well as the quality control data

  19. Guidelines for radriopharmaceutical quality control in hospitals

    International Nuclear Information System (INIS)

    Welsh, W.J.

    1982-01-01

    This document has been prepared to assist hospital administrators in ensuring that adequate quality control is performed on radiopharmaceuticals administered to their patients. Three sets of guidelines are presented, the degree of sophistication being dependent on the amount of hospital involvement in the radiopharmaceutical preparation

  20. Quality Control Of Selected Pesticides With GC

    Energy Technology Data Exchange (ETDEWEB)

    Karasali, H. [Benaki Phytopathological Institute Laboratory of Physical and Chemical Analysis of Pesticides, Ekalis (Greece)

    2009-07-15

    The practical quality control of selected pesticides with GC is treated. Detailed descriptions are given on materials and methods used, including sample preparation and GC operating conditions. The systematic validation of multi methods is described, comprising performance characteristics in routine analysis, like selectivity, specificity etc. This is illustrated by chromatograms, calibration curves and tables derived from real laboratory data. (author)

  1. Outsourcing University Degrees: Implications for Quality Control

    Science.gov (United States)

    Edwards, Julie; Crosling, Glenda; Edwards, Ron

    2010-01-01

    Education institutions worldwide have and continue to seek opportunities to spread their offerings abroad. While the provision of courses to students located overseas through partner institutions has many advantages, it raises questions about quality control that are not as applicable to other forms of international education. This paper uses a…

  2. Higher cardio-respiratory fitness is associated with increased mental and physical quality of life in people with bipolar disorder: A controlled pilot study.

    Science.gov (United States)

    Vancampfort, Davy; Hagemann, Noemi; Wyckaert, Sabine; Rosenbaum, Simon; Stubbs, Brendon; Firth, Joseph; Schuch, Felipe B; Probst, Michel; Sienaert, Pascal

    2017-10-01

    The aim of this study was to investigate whether cardiorespiratory fitness among outpatients with bipolar disorder is associated with health related quality of life (HRQL) and explore differences versus healthy controls. Outpatients with bipolar disorder and healthy controls matched for age, sex and body mass index completed the 36-item Short Form Health Survey, the Positive-and-Negative-Affect-Schedule (PANAS), a maximal cardiorespiratory fitness test, and wore a Sensewear Armband to measure physical activity and sedentary behavior for eight days. Unpaired t-tests, Pearson correlations and backward regression analyses were performed. Outpatients with bipolar disorder (n = 20; 14♀; 47.9 ± 7.9 years) had a significantly lower physical and mental HRQL than healthy controls (n = 20; 14♀; 47.8 ± 7.6 years), a lower maximum oxygen uptake (VO 2 max) and were more sedentary. While no significant correlates were found for HRQL in controls, higher VO 2 max values and lower PANAS negative affect scores predicted better physical and mental HRQL in people with bipolar disorder. The final regression model explained 68% and 58% of the variability in physical and mental HRQL respectively. Cardiorespiratory fitness is associated with mental and physical HRQL among people with bipolar disorder. The current study offers novel targets for scientific investigation and clinical interventions to increase HRQL in people with bipolar disorder. Copyright © 2017 Elsevier B.V. All rights reserved.

  3. Requirements for quality control of analytical data

    International Nuclear Information System (INIS)

    Westmoreland, R.D.; Bartling, M.H.

    1990-07-01

    The National Contingency Plan (NCP) of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) provides procedures for the identification, evaluation, and remediation of past hazardous waste disposal sites. The Hazardous Materials Response section of the NCP consists of several phases: Preliminary Assessment, Site Inspection, Remedial Investigation, Feasibility Study, Remedial Design, and Remedial Action. During any of these phases, analysis of soil, water, and waste samples may be performed. The Hazardous Waste Remedial Actions Program (HAZWRAP) is involved in performing field investigations and sample analyses pursuant to the NCP for the US Department of Energy and other federal agencies. The purpose of this document is to specify the requirements of Martin Marietta Energy Systems, Inc., for the control of accuracy, precision, and completeness of samples and data from the point of collection through analysis. Requirements include data reduction and reporting of resulting environmentally related data. Because every instance and concern may not be addressed in this document, HAZWRAP subcontractors are encouraged to discuss any questions with the Analytical Quality Control Specialist (AQCS) and the HAZWRAP Project Manager. This revision supercedes all other versions of this document

  4. Impact on quality of life of a nursing intervention programme for patients with chronic non-cancer pain: an open, randomized controlled parallel study protocol.

    Science.gov (United States)

    Morales-Fernandez, Angeles; Morales-Asencio, Jose Miguel; Canca-Sanchez, Jose Carlos; Moreno-Martin, Gabriel; Vergara-Romero, Manuel

    2016-05-01

    To determine the effect of a nurse-led intervention programme for patients with chronic non-cancer pain. Chronic non-cancer pain is a widespread health problem and one that is insufficiently controlled. Nurses can play a vital role in pain management, using best practices in the assessment and management of pain under a holistic approach where the patient plays a proactive role in addressing the disease process. Improving the quality of life, reducing disability, achieving acceptance of health status, coping and breaking the vicious circle of pain should be the prime objectives of our care management programme. Open randomized parallel controlled study. The experimental group will undertake one single initial session, followed by six group sessions led by nurses, aimed at empowering patients for the self-management of pain. Healthy behaviours will be encouraged, such as sleep and postural hygiene, promotion of physical activity and healthy eating. Educational interventions on self-esteem, pain-awareness, communication and relaxing techniques will be carried out. As primary end points, quality of life, perceived level of pain, anxiety and depression will be evaluated. Secondary end points will be coping and satisfaction. Follow-up will be performed at 12 and 24 weeks. The study was approved by the Ethics and Research Committee Costa del Sol. If significant effects were detected, impact on quality of life through a nurse-led programme would offer a complementary service to existing pain clinics for a group of patients with frequent unmet needs. © 2016 John Wiley & Sons Ltd.

  5. Evaluation of the effectiveness of music therapy in improving the quality of life of palliative care patients: a randomised controlled pilot and feasibility study.

    Science.gov (United States)

    McConnell, Tracey; Graham-Wisener, Lisa; Regan, Joan; McKeown, Miriam; Kirkwood, Jenny; Hughes, Naomi; Clarke, Mike; Leitch, Janet; McGrillen, Kerry; Porter, Sam

    2016-01-01

    Music therapy is frequently used as a palliative therapy. In consonance with the goals of palliative care, the primary aim of music therapy is to improve people's quality of life by addressing their psychological needs and facilitating communication. To date, primarily because of a paucity of robust research, the evidence for music therapy's effectiveness on patient reported outcomes is positive but weak. This pilot and feasibility study will test procedures, outcomes and validated tools; estimate recruitment and attrition rates; and calculate the sample size required for a phase III randomised trial to evaluate the effectiveness of music therapy in improving the quality of life of palliative care patients. A pilot randomised controlled trial supplemented with qualitative methods. The quantitative data collection will involve recruitment of >52 patients from an inpatient Marie Curie hospice setting over a 12-month period. Eligibility criteria include all patients with an Eastern Cooperative Oncology Group (ECOG) performance status of 03- indicating they are medically fit to engage with music therapy and an Abbreviated Mental Test (AMT) score of ≥7 indicating they are capable of providing meaningful informed consent and accurate responses to outcome measures. Baseline data collection will include the McGill Quality of Life Questionnaire (MQOL); medical and socio-demographic data will be undertaken before randomisation to an intervention or control group. Participants in the intervention arm will be offered two 30-45 min sessions of music therapy per week for three consecutive weeks, in addition to care as usual. Participants in the control arm will receive care as usual. Follow-up measures will be administered in 1, 3 and 5 weeks. Qualitative data collection will involve focus group and individual interviews with HCPs and carers. This study will ensure a firm methodological grounding for the development of a robust phase III randomised trial of music therapy for

  6. Enhancing clinical effectiveness of pre-radiotherapy workflow by using multidisciplinary-cooperating e-control and e-alerts: A SQUIRE-compliant quality-improving study.

    Science.gov (United States)

    Lin, Yung-Hsiang; Hung, Shih-Kai; Lee, Moon-Sing; Chiou, Wen-Yen; Lai, Chun-Liang; Shih, Yi-Ting; Yeh, Pei-Han; Lin, Yi-An; Tsai, Wei-Ta; Hsieh, Hui-Ling; Chen, Liang-Cheng; Huang, Li-Wen; Lin, Po-Hao; Liu, Dai-Wei; Hsu, Feng-Chun; Tsai, Shiang-Jiun; Liu, Jia-Chi; Chung, En-Seu; Lin, Hon-Yi

    2017-06-01

    Radiotherapy (RT) is useful in managing cancer diseases. In clinical practice, early initiation of RT is crucial for enhancing tumor control. But, delivering precise RT requires a series of pre-RT working processes in a tight staff-cooperation manner. In this regard, using information system to conduct e-control and e-alerts has been suggested to improve practice effectiveness; however, this effect is not well defined in a real-world RT setting.We designed an information system to perform e-control and e-alerts for the whole process of pre-RT workflow to shorten processing time, to improve overall staff satisfaction, and to enhance working confidence.A quality-improving study conducted in a large RT center.Externally validated data were retrospectively analyzed for comparison before (from Sep. 2012 to Dec. 2012, n = 223) and after (from Sep. 2013 to Dec. 2013, n = 240) implementation of pre-RT e-control and e-alerts.Applying the e-control with delay-working e-alerts in pre-RT workflow was the main intervention.Nine workstations were identified in pre-RT workflow. The primary outcome measure was the processing time in each pre-RT workstations before and after implementing the e-control and e-alerts. Secondary measures were staff-working confidence and near-missing cases during the process of pre-RT workflow.After implementing e-control, overall processing time of pre-RT workflow was shortened from 12.2 days to 8.9 days (P workflow. Clinical effectiveness, staff satisfaction, and working confidence are able to be enhanced obviously.

  7. Effects of shared medical appointments on quality of life and cost-effectiveness for patients with a chronic neuromuscular disease. Study protocol of a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    van der Wilt Gert-Jan

    2011-08-01

    Full Text Available Abstract Background Shared medical appointments are a series of one-to-one doctor-patient contacts, in presence of a group of 6-10 fellow patients. This group visits substitute the annual control visits of patients with the neurologist. The same items attended to in a one-to- one appointment are addressed. The possible advantages of a shared medical appointment could be an added value to the present management of neuromuscular patients. The currently problem-focused one-to-one out-patient visits often leave little time for the patient's psychosocial needs, patient education, and patient empowerment. Methods/design A randomized, prospective controlled study (RCT with a follow up of 6 months will be conducted to evaluate the clinical and cost-effectiveness of shared medical appointments compared to usual care for 300 neuromuscular patients and their partners at the Radboud University Nijmegen Medical Center. Every included patient will be randomly allocated to one of the two study arms. This study has been reviewed and approved by the medical ethics committee of the region Arnhem-Nijmegen, the Netherlands. The primary outcome measure is quality of life as measured by the EQ-5D, SF-36 and the Individualized neuromuscular Quality of Life Questionnaire. The primary analysis will be an intention-to-treat analysis on the area under the curve of the quality of life scores. A linear mixed model will be used with random factor group and fixed factors treatment, baseline score and type of neuromuscular disease. For the economic evaluation an incremental cost-effectiveness analysis will be conducted from a societal perspective, relating differences in costs to difference in health outcome. Results are expected in 2012. Discussion This study will be the first randomized controlled trial which evaluates the effect of shared medical appointments versus usual care for neuromuscular patients. This will enable to determine if there is additional value of shared

  8. The role and relevance of quality assurance to quality control

    International Nuclear Information System (INIS)

    Churchill, G.F.

    1989-01-01

    The paper describes the development of Quality Assurance as a total management technique, incorporating manufacturing and construction Quality Control, to give confidence of satisfactory in-service performance. The application of QA to the Heysham 2 and Torness AGR projects design and construction is defined with particular reference to the development of a QA requirements specification, delegation of QA responsibility through the hierarchy of purchasers and suppliers of plant and material, the role of the QA organization and QA auditing. The paper discusses the effectiveness and benefits of QA and the problems identified in its application and implementation. The problems, their solutions and longer term improvements to reduce the costs of QA as well as enhancing confidence in the satisfactory performance of future nuclear projects, are described. (author)

  9. Quality control of PET/CT

    International Nuclear Information System (INIS)

    Angelova, J.; Zajcharov, M.

    2013-01-01

    Full text: Introduction: The aim of this work is to undertake a review of the methods for checking and adjusting the computer and positron emission tomography in the Hospital 'Alexandrovska' by the attached to the equipment phantoms according to the manufacturer prescription in order to fulfill its requirements for the entry of the main parameters image within certain limits. Materials and Methods: At the start of work a check of the lasers setting for patient positioning and 'heat' of the X-ray tube scanner to better image quality were made. Daily verification procedures on the image quality of CT through the water phantom and weekly - 'air' calibration were carried out. In positron part, daily control involves setting the resolution and sensitivity of the scanner through built Ga68 phantom. When commissioning, after repair and at least once a year, it is necessary to verify the accuracy of registration of the pulses from the crystal with a water phantom of known volume and the coincidence between CT and PET image. Results: The process of quality control is interactive. The results are displayed in tables and graphically, with the goal the individual values to fall within the determined by manufacturers range and to meet the standards for image quality. If necessary, the procedure repeats several times until it is fulfilled. Conclusion: Ensuring the quality of the image in positron emission tomography combined with computed tomography, is inextricably linked to accurate and precise diagnosis of tumor processes in the human body

  10. Quality control in diagnostic mammography: myths, realities and their importance in the final image quality

    International Nuclear Information System (INIS)

    Mora Rodriguez, Patricia

    2011-01-01

    Mammography is the most used tool for early detection of breast cancer and reduce mortality from this cause. Studies with ionizing radiation it is important that be justified and provide a quality image to make the diagnosis, to get more benefits and fewer risks. The problem is the difficult to obtain an image of the breast. Therefore, the commitment to quality mammography is to maximize the contrast, definition, resolution and reliability, thus minimizing noise and dose. A mammogram performed without quality don't detect early breast cancer and the study doesn't have sense. Quality mammography requires trained and experienced staff, modern equipment and in good conditions, correct positioning, right technical factors and appropriate viewing conditions. In addition, quality programs are required to reach to ensure quality, control in testing techniques and image quality. (author) [es

  11. Quality assurance and quality control of nuclear engineering during construction phase

    International Nuclear Information System (INIS)

    Zhang Zhihua; Deng Yue; Liu Yaoguang; Xu Xianqi; Zhou Shan; Qian Dazhi; Zhang Yang

    2007-01-01

    The quality assurance (QA) and quality control (QC) is a very important work in the nuclear engineering. This paper starts with how to establish quality assurance system of nuclear engineering construction phase, then introduces several experiments and techniques such as the implementation of quality assurance program, the quality assurance and quality control of contractors, the quality surveillance and control of supervisory companies, quality assurance audit and surveillance of builders. (authors)

  12. A randomised control trial of prompt and feedback devices and their impact on quality of chest compressions--a simulation study.

    Science.gov (United States)

    Yeung, Joyce; Davies, Robin; Gao, Fang; Perkins, Gavin D

    2014-04-01

    This study aims to compare the effect of three CPR prompt and feedback devices on quality of chest compressions amongst healthcare providers. A single blinded, randomised controlled trial compared a pressure sensor/metronome device (CPREzy), an accelerometer device (Phillips Q-CPR) and simple metronome on the quality of chest compressions on a manikin by trained rescuers. The primary outcome was compression depth. Secondary outcomes were compression rate, proportion of chest compressions with inadequate depth, incomplete release and user satisfaction. The pressure sensor device improved compression depth (37.24-43.64 mm, p=0.02), the accelerometer device decreased chest compression depth (37.38-33.19 mm, p=0.04) whilst the metronome had no effect (39.88 mm vs. 40.64 mm, p=0.802). Compression rate fell with all devices (pressure sensor device 114.68-98.84 min(-1), p=0.001, accelerometer 112.04-102.92 min(-1), p=0.072 and metronome 108.24 min(-1) vs. 99.36 min(-1), p=0.009). The pressure sensor feedback device reduced the proportion of compressions with inadequate depth (0.52 vs. 0.24, p=0.013) whilst the accelerometer device and metronome did not have a statistically significant effect. Incomplete release of compressions was common, but unaffected by the CPR feedback devices. Users preferred the accelerometer and metronome devices over the pressure sensor device. A post hoc study showed that de-activating the voice prompt on the accelerometer device prevented the deterioration in compression quality seen in the main study. CPR feedback devices vary in their ability to improve performance. In this study the pressure sensor device improved compression depth, whilst the accelerometer device reduced it and metronome had no effect. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  13. Internal quality control: planning and implementation strategies.

    Science.gov (United States)

    Westgard, James O

    2003-11-01

    The first essential in setting up internal quality control (IQC) of a test procedure in the clinical laboratory is to select the proper IQC procedure to implement, i.e. choosing the statistical criteria or control rules, and the number of control measurements, according to the quality required for the test and the observed performance of the method. Then the right IQC procedure must be properly implemented. This review focuses on strategies for planning and implementing IQC procedures in order to improve the quality of the IQC. A quantitative planning process is described that can be implemented with graphical tools such as power function or critical-error graphs and charts of operating specifications. Finally, a total QC strategy is formulated to minimize cost and maximize quality. A general strategy for IQC implementation is recommended that employs a three-stage design in which the first stage provides high error detection, the second stage low false rejection and the third stage prescribes the length of the analytical run, making use of an algorithm involving the average of normal patients' data.

  14. Quality control activities in support of the plutonium workers study. Assessment of coding consistency for data collected at Rocky Flats

    International Nuclear Information System (INIS)

    Reyes, M.; Wilkinson, G.S.; Acquavella, J.F.

    1984-03-01

    The Plutonium Workers Study is a multifaceted epidemiologic investigation of workers at six Department of Energy (DOE) facilities: Los Alamos, Rocky Flats, Mound, Savannah River, Oak Ridge, and Hanford. Information from a variety of record sources has been collected and abstracted for these studies. This report considers the accuracy of the demographic, occupational, and radiation exposure data collected for studies at Rocky Flats. the majority of the information was accurately abstracted, and analyses based on these data may be conducted

  15. Efficacy of omeprazole on cough, pulmonary function and quality of life of patients with sulfur mustard lung injury: A placebo-control, cross-over clinical trial study

    Directory of Open Access Journals (Sweden)

    Mohammad Hossein Emami

    2014-01-01

    Full Text Available Background: Gastro-esophageal reflux disease (GERD is prevalent and related to more severe disease in patients with respiratory problems. We evaluated the effects of antireflux therapy in warfare victims of exposure to Mustard gas with chronic cough. Materials and Methods: This randomized, double-blind, placebo-controlled, cross-over study was conducted on 45 cases of sulfur mustard injury with chronic cough (≥8 weeks and GERD. Patients were randomized into two groups, receiving either 20 mg twice daily omeprazole-placebo (OP or matching placebo (placebo-omeprazole [PO] for 4 months, followed by a 1-month washout period and the alternative treatment for 4 months. Assessments included GERD and cough, quality of life, and pulmonary function using spirometry. Leicester Cough Questionnaire and SF-36 were used for measuring quality of life. Results: Patients in the OP group experienced a more decrease than those in the PO group in severity of Leicester cough scores during the first 4-month of trial. After crossing the groups, the OP group experienced an increase (P = 0.036 and the PO group experienced a nonsignificant decrease (P = 0.104 in the severity of scores. The OP group also experienced improvement in GERD symptoms and quality of life at the end of the trial, but changes in the PO group was not significant. There was no significant change in respiratory function indices in any groups. Conclusion: Long-term treatment with high-dose omeprazole improved GERD as well as cough, and quality of life, but not changed respiratory function indices in sulfur mustard injured cases with respiratory symptoms.

  16. A falls prevention programme to improve quality of life, physical function and falls efficacy in older people receiving home help services: study protocol for a randomised controlled trial.

    Science.gov (United States)

    Bjerk, Maria; Brovold, Therese; Skelton, Dawn A; Bergland, Astrid

    2017-08-14

    Falls and fall-related injuries in older adults are associated with great burdens, both for the individuals, the health care system and the society. Previous research has shown evidence for the efficiency of exercise as falls prevention. An understudied group are older adults receiving home help services, and the effect of a falls prevention programme on health-related quality of life is unclear. The primary aim of this randomised controlled trial is to examine the effect of a falls prevention programme on quality of life, physical function and falls efficacy in older adults receiving home help services. A secondary aim is to explore the mediating factors between falls prevention and health-related quality of life. The study is a single-blinded randomised controlled trial. Participants are older adults, aged 67 or older, receiving home help services, who are able to walk with or without walking aids, who have experienced at least one fall during the last 12 months and who have a Mini Mental State Examination of 23 or above. The intervention group receives a programme, based on the Otago Exercise Programme, lasting 12 weeks including home visits and motivational telephone calls. The control group receives usual care. The primary outcome is health-related quality of life (SF-36). Secondary outcomes are leg strength, balance, walking speed, walking habits, activities of daily living, nutritional status and falls efficacy. All measurements are performed at baseline, following intervention at 3 months and at 6 months' follow-up. Sample size, based on the primary outcome, is set to 150 participants randomised into the two arms, including an estimated 15-20% drop out. Participants are recruited from six municipalities in Norway. This trial will generate new knowledge on the effects of an exercise falls prevention programme among older fallers receiving home help services. This knowledge will be useful for clinicians, for health managers in the primary health care service

  17. Quality control chart for crushed granite concrete

    Directory of Open Access Journals (Sweden)

    Ewa E. DESMOND

    2016-07-01

    Full Text Available A chart for assessing in-situ grade (strength of concrete, has been developed in this study. Four grades of concrete after the Nigerian General Specification for Roads and bridges (NGSRB-C20, C25, C30 and C35, is studied at different water-cement ratios for medium and high slump range. The concrete mixes are made from crushed granite rock as coarse aggregate with river sand as fine aggregate. Compression test on specimens are conducted at curing age of 1, 3, 7, 14, 21, 28 and 56 days. Results on concrete workability from slump values, and water-cement ratios revealed that specimens with lower water-cement ratio were less workable but had higher strength, compared to mixes with higher water cement ratio. A simple algorithm using nonlinear regression analysis performed on each experimental data set produced Strength-Age (S-A curves which were used to establish a quality control chart. The accuracy of these curves were evaluated by computing average absolute error (AAS, the error of estimate (EoE and the average absolute error of estimate (Abs EoE for each concrete mix. These were done based on the actual average experimental strengths to measure how close the predicted values are to the experimental data set. The absolute average error of estimate (Abs. EoE recorded was less than ±10% tolerance zone for concrete works.

  18. 42 CFR 84.40 - Quality control plans; filing requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Quality control plans; filing requirements. 84.40... Control § 84.40 Quality control plans; filing requirements. As a part of each application for approval or... proposed quality control plan which shall be designed to assure the quality of respiratory protection...

  19. 21 CFR 211.22 - Responsibilities of quality control unit.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Responsibilities of quality control unit. 211.22... Personnel § 211.22 Responsibilities of quality control unit. (a) There shall be a quality control unit that... have been fully investigated. The quality control unit shall be responsible for approving or rejecting...

  20. 30 CFR 28.30 - Quality control plans; filing requirements.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality control plans; filing requirements. 28... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.30 Quality control plans; filing... part, each applicant shall file with MSHA a proposed quality control plan which shall be designed to...

  1. The effects of using the Internet on the health-related quality of life in people with spinal cord injury: a controlled study.

    Science.gov (United States)

    Celik, B; Ones, K; Celik, E C; Bugdayci, D S; Paker, N; Avci, C; Ince, N

    2014-05-01

    Prospective cohort study. To compare the health-related quality of life (HRQoL) in people with spinal cord injury (SCI) who use the Internet versus those who don't and with a control group of able-bodied individuals. To investigate the frequency of Internet usage before and after injury. To evaluate the differences in terms of demographic features of both groups, analyze the variation in the Internet usage pattern of people with SCI before and after the injury. Istanbul, Turkey. A total of 60 people with SCI (38 Internet users, 22 nonusers) were included in the study. The control group consisted of 33 healthy persons of similar age and sex. The HRQoL was evaluated with the SF-36 Health Survey. The scores of all the subscales of the SF-36, except vitality, were significantly lower in people with SCI than those of the controls'. The bodily pain subscale and physical component scores were found to be significantly higher in people with SCI using the Internet than the nonuser group with SCI (PInternet usage frequency increased significantly in people with SCI after injury (PInternet use (r=0.365, P=0.007). Although HRQoL scores were lower in people with an SCI, the physical status component score was better in the Internet user SCI group. As there is a significant increase in the time spent online after injury, the Internet could be an effective modality to contact and educate people with an SCI.

  2. Quality Controlling CMIP datasets at GFDL

    Science.gov (United States)

    Horowitz, L. W.; Radhakrishnan, A.; Balaji, V.; Adcroft, A.; Krasting, J. P.; Nikonov, S.; Mason, E. E.; Schweitzer, R.; Nadeau, D.

    2017-12-01

    As GFDL makes the switch from model development to production in light of the Climate Model Intercomparison Project (CMIP), GFDL's efforts are shifted to testing and more importantly establishing guidelines and protocols for Quality Controlling and semi-automated data publishing. Every CMIP cycle introduces key challenges and the upcoming CMIP6 is no exception. The new CMIP experimental design comprises of multiple MIPs facilitating research in different focus areas. This paradigm has implications not only for the groups that develop the models and conduct the runs, but also for the groups that monitor, analyze and quality control the datasets before data publishing, before their knowledge makes its way into reports like the IPCC (Intergovernmental Panel on Climate Change) Assessment Reports. In this talk, we discuss some of the paths taken at GFDL to quality control the CMIP-ready datasets including: Jupyter notebooks, PrePARE, LAMP (Linux, Apache, MySQL, PHP/Python/Perl): technology-driven tracker system to monitor the status of experiments qualitatively and quantitatively, provide additional metadata and analysis services along with some in-built controlled-vocabulary validations in the workflow. In addition to this, we also discuss the integration of community-based model evaluation software (ESMValTool, PCMDI Metrics Package, and ILAMB) as part of our CMIP6 workflow.

  3. Suggestion for improvement of PET quality control tests in Brazil

    International Nuclear Information System (INIS)

    Ferreira, Fernanda C.L.; Magalhaes, Cinthia M.S.; Souza, Divanizia N.

    2009-01-01

    Nowadays nuclear medicine has a considerable importance among the other medical specialties. This medical specialty utilizes high-tech equipment for imaging in the diagnosis, obtaining information on the clinical functionality of organs and systems of the human body through the use of radioisotopes . In view of the importance of guaranteeing the image quality in SPECT and PET systems, enabling patients not repeat exams due to lack of quality control of equipment used in nuclear medicine, this paper aims to present a possible suggestion to update the quality control tests needed for quality assurance of nuclear medicine services. They were considered the requirements of the National Commission of Nuclear Energy (CNEN) and the National Health Surveillance Agency (ANVISA) in Brazil. The minimum requirements to be defined for inclusion of quality control tests on PET in the standard CNEN are extremely important because they will guide the evaluation of PET systems, determining the quality control tests to be performed. And those tests for PET will be a regulatory requirement by the CNEN and ANVISA. As the National Health Surveillance Agency has already publication of RDC 38 with recommendations for services of nuclear medicine. This study will continue with evaluation of PET systems and presenting the tests of quality control with additional objects and simulators to ensure safety in PET systems have not standardized in nuclear medicine services in Brazil. (author)

  4. Tc-99m direct radiolabeling of monoclonal antibody ior egf/r3: quality control and image studies in mice

    International Nuclear Information System (INIS)

    Dias, Carla Roberta; Marczewski, Barbara; Moraes, Vanessa; Barboza, Marycel Figols de; Osso Junior, Joao Alberto

    2005-01-01

    Monoclonal antibodies (Mabs) have been useful for immunoscintigraphic applications in clinical diagnosis since they were introduced in the practice of nuclear medicine. The ior egf/r3 (Centis, Cuba) is a murine monoclonal antibody against epidermal growth factor receptor (EGF-R) and has been widely used in the radioimmunodiagnosis of tumors of epithelial origin. Labeled with 99m Tc, its main application in Nuclear Medicine is the follow up, detection and evaluation of tumor recurrences. The objective of this work is to describe the preparation of a lyophilized formulation (kit) for radiolabeling the Mab ior egf/r3 with 99m Tc for immunoscintigraphic applications. Radiolabeling efficiency, effects on immunoreactivity, image studies and stability of the formulation are reported. The study demonstrated that the kit formulation can be labeled with 99m Tc at high yields and can be used to visualize in vivo human tumors of epithelial origin by immunoscintigraphy studies.(author)

  5. Determination and evaluation of air quality control. Manual of ambient air quality control in Germany

    Energy Technology Data Exchange (ETDEWEB)

    Lahmann, E.

    1997-07-01

    Measurement of air pollution emissions and ambient air quality are essential instruments for air quality control. By undertaking such measurements, pollutants are registered both at their place of origin and at the place where they may have an effect on people or the environment. Both types of measurement complement each other and are essential for the implementation of air quality legislation, particularly, in compliance with emission and ambient air quality limit values. Presented here are similar accounts of measurement principles and also contains as an Appendix a list of suitability-tested measuring devices which is based on information provided by the manufacturers. In addition, the guide of ambient air quality control contains further information on discontinuous measurement methods, on measurement planning and on the assessment of ambient air quality data. (orig./SR)

  6. Control of Bank Consolidated Financial Statements Quality

    Directory of Open Access Journals (Sweden)

    Margarita S. Ambarchyan

    2013-01-01

    Full Text Available The author presents the multiple linear regression model of bank consolidated financial statements quality. The article considers six characteristics that can be used to estimate the level of bank consolidated financial statements quality. The multiple linear regression model was developed, using the results of point-based system of consolidated financial statements of thirty European bank and financial groups on the basis of the developed characteristics. The author offers to use the characteristic significance factor in the process of consolidated financial statements appraisal by points. The constructed regression model is checked on accuracy and statistical significance. The model can be used by internal auditors and financial analytics as an instrument for bank and non-bank consolidated financial statements quality control

  7. Quality control of conventional radiographic facilities in Kinshasa

    International Nuclear Information System (INIS)

    Woto, M.L.; Lukanda, M.V.; Mulumba, L.C.P.; Palangu

    2009-01-01

    The continuous development of medical applications of ionizing radiation, due to the benefit derived by diagnostic or therapeutic patients, their diversity, ease of implementation, explains the importance of medical exposure. The latter is currently the leading cause of human exposure to artificial origin. The purpose of this study is to contribute to the optimization of radiographic facilities in the city of Kinshasa. This study has revealed that city of Kinshasa has an average of 122 medical training with conventional radiology facilities distributed in six districts of health. Of the 122 facilities, only 30 (or 24.59%) are controlled from the point of view of quality assurance. Some generators and X-ray tubes are respectively controlled adjustment and de centered, and other devices are cannibalized. So, nationally and particularly in Kinshasa, quality control equipment and diagnostic facilities is at a generally delayed compared with international recommendations of X W. Major efforts must be made at government level to raise awareness and establish a quality assurance program in diagnostic radiology. An awareness of the entire medical profession and the competent administrative authorities of medical devices could be beneficial to the quality of care delivered to patients, limiting radiation exposure and improving image quality and only the financial balance of the health sector. The delivery of quality care passes through the justification of acts, the development and dissemination of good practice references and the establishment of quality control radiological installations.

  8. Congenital malformations, chromosomal abnormalities and perinatal results in IVF/ICSI newborns resulting from very poor quality embryos: a case-control study.

    Science.gov (United States)

    Mendoza, R; Perez, S; de Los Santos, M J; Larreategui, Z; Ayerdi, F; Expósito, A; Burgos, J; Martínez Indart, L; Pijoan, J I; Matorras, R

    2015-01-01

    To explore whether the transfer of very poor quality (VPQ) embryos is associated with an increase in congenital malformations or perinatal problems. In this retrospective case-control study, 74 children conceived by in vitro fertilization (IVF) and/or intracytoplasmic sperm injection (ICSI) resulting exclusively from the transfer of VPQ embryos were compared with 1,507 children born after the transfer of top morphological quality (TQ) embryos over the same period of time in the same centers. The prevalence of birth defects in children resulting from VPQ embryos was 1.35% (1/74), similar to the 1.72% (26/1,507) when only TQ embryos were transferred; the rate of chromosomal abnormalities detected was also similar (0.0 vs. 0.4%), as was perinatal mortality. After correcting for multiplicity (higher in the TQ group), the aforementioned parameters remained similar in the two groups. Congenital malformations and perinatal complications do not seem to be more common in children born after transfer of VPQ embryos in IVF/ICSI cycles. Given our preliminary data, which need to be confirmed in much larger studies, when only VPQ embryos are available for transfer in IVF/ICSI cycles, we do not believe that they should be discarded with the intention of avoiding birth defects or perinatal complications. © 2015 S. Karger AG, Basel.

  9. Quality Risk Management: Putting GMP Controls First.

    Science.gov (United States)

    O'Donnell, Kevin; Greene, Anne; Zwitkovits, Michael; Calnan, Nuala

    2012-01-01

    This paper presents a practical way in which current approaches to quality risk management (QRM) may be improved, such that they better support qualification, validation programs, and change control proposals at manufacturing sites. The paper is focused on the treatment of good manufacturing practice (GMP) controls during QRM exercises. It specifically addresses why it is important to evaluate and classify such controls in terms of how they affect the severity, probability of occurrence, and detection ratings that may be assigned to potential failure modes or negative events. It also presents a QRM process that is designed to directly link the outputs of risk assessments and risk control activities with qualification and validation protocols in the GMP environment. This paper concerns the need for improvement in the use of risk-based principles and tools when working to ensure that the manufacturing processes used to produce medicines, and their related equipment, are appropriate. Manufacturing processes need to be validated (or proven) to demonstrate that they can produce a medicine of the required quality. The items of equipment used in such processes need to be qualified, in order to prove that they are fit for their intended use. Quality risk management (QRM) tools can be used to support such qualification and validation activities, but their use should be science-based and subject to as little subjectivity and uncertainty as possible. When changes are proposed to manufacturing processes, equipment, or related activities, they also need careful evaluation to ensure that any risks present are managed effectively. This paper presents a practical approach to how QRM may be improved so that it better supports qualification, validation programs, and change control proposals in a more scientific way. This improved approach is based on the treatment of what are called good manufacturing process (GMP) controls during those QRM exercises. A GMP control can be considered

  10. EFFECT OF QUALITY CONTROL SYSTEM ON AUDIT QUALITY WITH PROFESSIONAL COMMITMENTS AS A MODERATION VARIABLE

    Directory of Open Access Journals (Sweden)

    Ramadhani R.

    2017-12-01

    Full Text Available This study aims to test the effect of every element of Quality Control System (QCS that is leadership responsibilities for quality on audit, relevant ethical requirements, acceptance and continuance of client relationships and certain engagements, assignment of engagement team, engagement performance, monitoring, and documentation on audit quality as well as to test whether the professional commitment moderate effect of every element of QCS on audit quality. The population was the staff auditors working in public accounting firms domiciled in Jakarta City, especially Central Jakarta area with the drawing of 84 respondents. The statistical method used was SEM PLS with the help of SmartPLS application. The results of this study indicate that from seven elements of QCS, only relevant ethical requirements that affect on audit quality. Furthermore, the study also found that professional commitment cannot moderate the relationship between the seven elements of QCS on audit quality.

  11. Randomized, placebo controlled study of the effect of propentofylline on survival time and quality of life of cats with feline infectious peritonitis.

    Science.gov (United States)

    Fischer, Y; Ritz, S; Weber, K; Sauter-Louis, C; Hartmann, K

    2011-01-01

    Currently there is no drug proven to effectively treat cats with feline infectious peritonitis (FIP). Propentofylline (PPF) can decrease vasculitis, and therefore prolong survival time in cats with FIP, and increase their quality of life. Twenty-three privately owned cats with FIP. Placebo-controlled double-blind trial. FIP was confirmed by histology or immunostaining of feline coronavirus (FCoV) antigen in effusion or tissue macrophages or both. The cats were randomly selected for treatment with either PPF or placebo. All cats received additional treatment with glucocorticoids, antibiotics, and low molecular weight heparin according to methods. There was no statistically significant difference in the survival time of cats treated with PPF (8 days, 95% CI 5.4-10.6) versus placebo (7.5 days, 95% CI 4.4-9.6). The median survival time of all cats was 8 days (4-36 days). There was neither a difference in quality of life (day 7, P = .892), in the amount of effusion (day 7, P = .710), the tumor necrosis factor-alpha (TNF-α) concentration (day 7, P = .355), nor in any other variable investigated in this study, including a complete blood count, and a small animal biochemistry profile. This study did not detect an effect of PPF on the survival time, the quality of life, or any clinical or laboratory parameter in cats with FIP. Therefore, PPF does not appear to be an effective treatment option in cats with a late stage of the disease FIP. Copyright © 2011 by the American College of Veterinary Internal Medicine.

  12. Quality Control Assessment of Radiology Devices in Kerman Province, Iran

    OpenAIRE

    Zahra Jomehzadeh; Ali Jomehzadeh; Mohammad Bagher Tavakoli

    2016-01-01

    Introduction Application of quality control (QC) programs at diagnostic radiology departments is of great significance for optimization of image quality and reduction of patient dose. The main objective of this study was to perform QC tests on stationary radiographic X-ray machines, installed in 14 hospitals of Kerman province, Iran. Materials and Methods In this cross-sectional study, QC tests were performed on 28 conventional radiographic X-ray units in Kerman governmental hospitals, based ...

  13. 99m Tc-tazobactam, a novel infection imaging agent: Radiosynthesis, quality control, biodistribution, and infection imaging studies.

    Science.gov (United States)

    Rasheed, Rashid; Naqvi, Syed Ali Raza; Gillani, Syed Jawad Hussain; Zahoor, Ameer Fawad; Jielani, Asif; Saeed, Nidda

    2017-05-15

    The radiolabeled drug 99m Tc-tazobactam ( 99m Tc-TZB) was developed and assessed as an infection imaging agent in Pseudomonas aeruginosa and Salmonella enterica infection-induced animal models by comparing with inflammation induced animal models. Radiosynthesis of 99m Tc-TZB was assessed while changing ligand concentration, reducing agent concentration, pH, and reaction time while keeping radioactivity constant (~370 MBq). Percent labeling of the resulting complex was measured using paper chromatography and instant thin layer chromatography. The analysis of the 99m Tc-TZB complex indicated >95% labeling yield and electrophoresis revealed complex is neutral in nature. The biodistribution study also showed predominantly renal excretion; however liver, stomach, and intestine also showed slight tracer agent uptake. The agent significantly accumulated in Pseudomonas aeruginosa and Salmonella enterica infection induced tissues 3.58 ± 0.26% and 2.43 ± 0.42% respectively at 1 hour postinjection. The inflamed tissue failed to uptake noticeable activity at 1 hour time point. The scintigraphic study results were found in accordance with biodistribution pattern. On the basis of our preliminary results, the newly developed 99m Tc-TZB can be used to diagnose bacterial infection and to discriminate between infected and inflamed tissues. Copyright © 2017 John Wiley & Sons, Ltd.

  14. QUALITY CONTROL OF SOME TRADITIONAL MEAT PRODUCTS

    Directory of Open Access Journals (Sweden)

    S. DOBRINAS

    2014-03-01

    Full Text Available In this paper, we present the characterization of six traditional meat products: smoked file, smoked bacon, pork sausages, sausage prepared from swine’s entrails, pork pastrami, sheep sausages. Organoleptic tests (the aspect and shape, the aspect of freshly cut in the section, smell, taste and consistency, physico-chemical and microbiological determinations (NTG, Salmonella, Listeria monocytogenes and Escherichia coli were performed. These analyzes are a part of quality control that must be done in order to obtain a certificate from the Ministry of Agriculture for a traditional product. After identification of H2S and starch and according to fat oxidation degree it was concluded that analyzed samples didn’t contain counterfeiters and all parameters analyzed are within the maximum limits allowed by law. Considering all the procedures for manufacturing, characteristics of raw and auxiliary materials, organoleptic properties of final products analyzed in this study, it can be concluded that analyzed meat specialties meet the requirements of Ministry Order no. 690/28.09.2004 for the traditional products certification.

  15. Bacterial lipoproteins; biogenesis, sorting and quality control.

    Science.gov (United States)

    Narita, Shin-Ichiro; Tokuda, Hajime

    2017-11-01

    Bacterial lipoproteins are a subset of membrane proteins localized on either leaflet of the lipid bilayer. These proteins are anchored to membranes through their N-terminal lipid moiety attached to a conserved Cys. Since the protein moiety of most lipoproteins is hydrophilic, they are expected to play various roles in a hydrophilic environment outside the cytoplasmic membrane. Gram-negative bacteria such as Escherichia coli possess an outer membrane, to which most lipoproteins are sorted. The Lol pathway plays a central role in the sorting of lipoproteins to the outer membrane after lipoprotein precursors are processed to mature forms in the cytoplasmic membrane. Most lipoproteins are anchored to the inner leaflet of the outer membrane with their protein moiety in the periplasm. However, recent studies indicated that some lipoproteins further undergo topology change in the outer membrane, and play critical roles in the biogenesis and quality control of the outer membrane. This article is part of a Special Issue entitled: Bacterial Lipids edited by Russell E. Bishop. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. Chronic Low Quality Sleep Impairs Postural Control in Healthy Adults.

    Science.gov (United States)

    Furtado, Fabianne; Gonçalves, Bruno da Silva B; Abranches, Isabela Lopes Laguardia; Abrantes, Ana Flávia; Forner-Cordero, Arturo

    2016-01-01

    The lack of sleep, both in quality and quantity, is an increasing problem in modern society, often related to workload and stress. A number of studies have addressed the effects of acute (total) sleep deprivation on postural control. However, up to date, the effects of chronic sleep deficits, either in quantity or quality, have not been analyzed. Thirty healthy adults participated in the study that consisted of registering activity with a wrist actigraph for more than a week before performing a series of postural control tests. Sleep and circadian rhythm variables were correlated and the sum of activity of the least active 5-h period, L5, a rhythm variable, obtained the greater coefficient value with sleep quality variables (wake after sleep onset WASO and efficiency sleep). Cluster analysis was performed to classify subjects into two groups based on L5 (low and high). The balance tests scores used to asses postural control were measured using Biodex Balance System and were compared between the two groups with different sleep quality. The postural tests were divided into dynamic (platform tilt with eyes open, closed and cursor) and static (clinical test of sensory integration). The results showed that during the tests with eyes closed, the group with worse sleep quality had also worse postural control performance. Lack of vision impairs postural balance more deeply in subjects with chronic sleep inefficiency. Chronic poor sleep quality impairs postural control similarly to total sleep deprivation.

  17. [Pharmaceutical product quality control and good manufacturing practices].

    Science.gov (United States)

    Hiyama, Yukio

    2010-01-01

    This report describes the roles of Good Manufacturing Practices (GMP) in pharmaceutical product quality control. There are three keys to pharmaceutical product quality control. They are specifications, thorough product characterization during development, and adherence to GMP as the ICH Q6A guideline on specifications provides the most important principles in its background section. Impacts of the revised Pharmaceutical Affairs Law (rPAL) which became effective in 2005 on product quality control are discussed. Progress of ICH discussion for Pharmaceutical Development (Q8), Quality Risk Management (Q9) and Pharmaceutical Quality System (Q10) are reviewed. In order to reconstruct GMP guidelines and GMP inspection system in the regulatory agencies under the new paradigm by rPAL and the ICH, a series of Health Science studies were conducted. For GMP guidelines, product GMP guideline, technology transfer guideline, laboratory control guideline and change control system guideline were written. For the GMP inspection system, inspection check list, inspection memo and inspection scenario were proposed also by the Health Science study groups. Because pharmaceutical products and their raw materials are manufactured and distributed internationally, collaborations with other national authorities are highly desired. In order to enhance the international collaborations, consistent establishment of GMP inspection quality system throughout Japan will be essential.

  18. Chronic Low Quality Sleep Impairs Postural Control in Healthy Adults.

    Directory of Open Access Journals (Sweden)

    Fabianne Furtado

    Full Text Available The lack of sleep, both in quality and quantity, is an increasing problem in modern society, often related to workload and stress. A number of studies have addressed the effects of acute (total sleep deprivation on postural control. However, up to date, the effects of chronic sleep deficits, either in quantity or quality, have not been analyzed. Thirty healthy adults participated in the study that consisted of registering activity with a wrist actigraph for more than a week before performing a series of postural control tests. Sleep and circadian rhythm variables were correlated and the sum of activity of the least active 5-h period, L5, a rhythm variable, obtained the greater coefficient value with sleep quality variables (wake after sleep onset WASO and efficiency sleep. Cluster analysis was performed to classify subjects into two groups based on L5 (low and high. The balance tests scores used to asses postural control were measured using Biodex Balance System and were compared between the two groups with different sleep quality. The postural tests were divided into dynamic (platform tilt with eyes open, closed and cursor and static (clinical test of sensory integration. The results showed that during the tests with eyes closed, the group with worse sleep quality had also worse postural control performance. Lack of vision impairs postural balance more deeply in subjects with chronic sleep inefficiency. Chronic poor sleep quality impairs postural control similarly to total sleep deprivation.

  19. Microbiological Quality Control of Probiotic Products

    OpenAIRE

    Astashkina, A.P.; Khudyakova, L.I.; Kolbysheva, Y.V.

    2014-01-01

    Microbiological quality control of probiotic products such as Imunele, Dannon, Pomogayka showed that they contain living cultures of the Lactobacillus Bifidobacterium genus in the amount of 107 CFU/ml, which corresponds to the number indicated on the label of products. It is identified that the survival rate of test-strains cultured with pasteurized products does not exceed 10%. The cell concentration of target-microorganisms was reduced by 20-45% after the interaction with living probiotic b...

  20. Mitochondrial quality control in cardiac diseases.

    Directory of Open Access Journals (Sweden)

    Juliane Campos

    2016-10-01

    Full Text Available Disruption of mitochondrial homeostasis is a hallmark of cardiac diseases. Therefore, maintenance of mitochondrial integrity through different surveillance mechanisms is critical for cardiomyocyte survival. In this review, we discuss the most recent findings on the central role of mitochondrial quality control processes including regulation of mitochondrial redox balance, aldehyde metabolism, proteostasis, dynamics and clearance in cardiac diseases, highlighting their potential as therapeutic targets.

  1. Quality control of estrogen receptor assays.

    Science.gov (United States)

    Godolphin, W; Jacobson, B

    1980-01-01

    Four types of material have been used for the quality control of routine assays of estrogen receptors in human breast tumors. Pieces of hormone-dependent Nb rat mammary tumors gave a precision about 40%. Rat uteri and rat tumors pulverized at liquid nitrogen temperature and stored as powder yielded precision about 30%. Powdered and lyophilised human tumors appear the best with precision as good as 17%.

  2. Radiochemical study on preparation and quality control of 1-125/1-131 labelled some organic compounds for medical uses

    International Nuclear Information System (INIS)

    El-azoney, K.M.S.E.

    1997-01-01

    The main objective of this thesis is to investigate the optimum condition for the radioiodination of some organic compounds which find wide applications in nuclear medicine. Iodine-131 (T 1 /2= 8.04 d) which is of great importance in the field, are used for this purpose. long chain fatty acids such as 16-Bromo-hexadecanoic (16-brHDA) and -phenyl -fatty acids such as 15-p-iodophenyl pentadecanoic acid (p-IPPA) will be used as model substrates. 1- Labelling of 16-Br-HDA with Na 131 I. Labelling of 16-BrHDA will be investigated via the non-isotopic exchange between 16-Br HDA and Na 131 I to give 16- 131 IHDA. In order to obtain a high radiochemical yield with high radiochemical purity for the product 16- 131 IHDA, simple and fast methods will be followed. The influence of reagents concentrations, time, temperature, solvents and four quaternary ammonium salts as phase transfer catalysts with only one crown ether will be studied. The determination of reaction velocities and activation energies of catalysed systems was effected and compared with results on the dry state system. 2- Labelling of p-Ipa with Na 131 I. Radioiodination of 15-p-iodophenyl pentadecanoic acid is investigated by the nucleophilic substitution reaction via the isotopic exchange between p-Ipa and Na 131 I. As with 16-BrHDA, factors affecting the labelling yield such as reagent concentrations, solvents, reaction time, temperature and catalyst, is examine. The effect of different temperatures on the radiochemical yield of P- 131 Ipa is studied to determine the activation energy of the exchange reaction. Because of the necessity to separate the iodinated products from the starting materials, high performance liquid chromatographic techniques were applied for this purpose. 3.15 figs., 3.2 tabs., 179 refs

  3. Study and methodology development for quality control in the production process of iodine-125 radioactive sealed sources applied to brachytherapy

    International Nuclear Information System (INIS)

    Moura, Joao Augusto

    2009-01-01

    Today cancer is the second cause of death by disease in several countries, including Brazil. Excluding skin cancer, prostate cancer is the most incident in the population. Prostate tumor can be treated by several ways, including brachytherapy, which consists in introducing sealed radioactive sources (Iodine - 125 seeds) inside the tumor. The target region of treatment receives a high radiation dose, but healthy neighbor tissues receive a significantly reduced radiation dose. The seed is made of a welding sealed titanium capsule, 0.8 mm external diameter and 4.5 mm length, enclosing a 0.5 mm diameter silver wire with Iodine-125 adsorbed. After welded, the seeds have to be submitted to a leak test to prevent any radioactive material release. The aims of this work were: (a) the study of the different leakage test methods applied to radioactive seeds and recommended by the ISO 997820, (b) the choice of the appropriate method and (c) the flowchart determination of the process to be used during the seeds production. The essays exceeded the standards with the use of ultra-sound during immersion and the corresponding benefits to leakage detection. Best results were obtained with the immersion in distilled water at 20 degree C for 24 hours and distilled water at 70 degree C for 30 minutes. These methods will be used during seed production. The process flowchart has all the phases of the leakage tests according to the sequence determined in the experiments. (author)

  4. Effect of an integrated approach of yoga therapy on quality of life in osteoarthritis of the knee joint: A randomized control study

    Directory of Open Access Journals (Sweden)

    John Ebnezar

    2011-01-01

    Full Text Available Aim: This study was designed to evaluate the efficacy of addition of integrated yoga therapy to therapeutic exercises in osteoarthritis (OA of knee joints. Materials and Methods: This was a prospective randomized active control trial. A total of t participants with OA of knee joints between 35 and 80 years (yoga, 59.56 ± 9.54 and control, 59.42 ± 10.66 from the outpatient department of Dr. John′s Orthopedic Center, Bengaluru, were randomly assigned to receive yoga or physiotherapy exercises after transcutaneous electrical stimulation and ultrasound treatment of the affected knee joints. Both groups practiced supervised intervention (40 min per day for 2 weeks (6 days per week with followup for 3 months. The module of integrated yoga consisted of shithilikaranavyayama (loosening and strengthening, asanas, relaxation techniques, pranayama, meditation and didactic lectures on yama, niyama, jnana yoga, bhakti yoga, and karma yoga for a healthy lifestyle change. The control group also had supervised physiotherapy exercises. A total of 118 (yoga and 117 (control were available for final analysis. Results: Significant differences were observed within (P < 0.001, Wilcoxon′s and between groups (P < 0.001, Mann-Whitney U-test on all domains of the Short Form-36 (P < 0.004, with better results in the yoga group than in the control group, both at 15 th day and 90 th day. Conclusion: An integrated approach of yoga therapy is better than therapeutic exercises as an adjunct to transcutaneous electrical stimulation and ultrasound treatment in improving knee disability and quality of life in patients with OA knees.

  5. The application of statistical process control in linac quality assurance

    International Nuclear Information System (INIS)

    Li Dingyu; Dai Jianrong

    2009-01-01

    Objective: To improving linac quality assurance (QA) program with statistical process control (SPC) method. Methods: SPC is applied to set the control limit of QA data, draw charts and differentiate the random and systematic errors. A SPC quality assurance software named QA M ANAGER has been developed by VB programming for clinical use. Two clinical cases are analyzed with SPC to study daily output QA of a 6MV photon beam. Results: In the clinical case, the SPC is able to identify the systematic errors. Conclusion: The SPC application may be assistant to detect systematic errors in linac quality assurance thus it alarms the abnormal trend to eliminate the systematic errors and improves quality control. (authors)

  6. Effect of low-level laser therapy on pain, quality of life and sleep in patients with fibromyalgia: study protocol for a double-blinded randomized controlled trial.

    Science.gov (United States)

    de Carvalho, Paulo de Tarso Camillo; Leal-Junior, Ernesto Cesar Pinto; Alves, Ana Carolina Araruna; Rambo, Caroline Sobral de Melo; Sampaio, Luciana Maria Malosa; Oliveira, Claudia Santos; Albertini, Regiane; de Oliveira, Luis Vicente Franco

    2012-11-21

    Low-level laser therapy (LLLT) has been widely used as adjuvant strategy for treatment of musculoskeletal disorders. The light-tissue interaction (photobiostimulation) promotes analgesic and anti-inflammatory effects and improves tissue healing, which could justify the recommendation of this therapy for patients with fibromyalgia, leading to an improvement in pain and possibly minimizing social impact related to this disease. The present study proposes to evaluate the effect of LLLT on tender points in patients with fibromyalgia, correlating this outcome with quality of life and sleep. One hundred and twenty patients with fibromyalgia will be treated at the Integrated Health Center and the Sleep Laboratory of the Post Graduate Program in Rehabilitation Sciences of the Nove de Julho University located in the city of Sao Paulo, Brazil. After fulfilling the eligibility criteria, a clinical evaluation and assessments of pain and sleep quality will be carried out and self-administered quality of life questionnaires will be applied. The 120 volunteers will be randomly allocated to an intervention group (LLLT, n = 60) or control group (CLLLT, n = 60). Patients from both groups will be treated three times per week for four weeks, totaling twelve sessions. However, only the LLLT group will receive an energy dose of 6 J per tender point. A standardized 50-minute exercise program will be performed after the laser application. The patients will be evaluated regarding the primary outcome (pain) using the following instruments: visual analog scale, McGill Pain Questionnaire and pressure algometry. The secondary outcome (quality of life and sleep) will be assessed with the following instruments: Medical Outcomes Study 36-item Short-Form Health Survey, Fibromyalgia Impact Questionnaire, Berlin Questionnaire, Epworth Sleepiness Scale and polysomnography. ANOVA test with repeated measurements for the time factor will be performed to test between-groups differences (followed by the

  7. Impact of GnRH analogues on oocyte/embryo quality and embryo development in in vitro fertilization/intracytoplasmic sperm injection cycles: a case control study

    Directory of Open Access Journals (Sweden)

    Rigó János

    2009-09-01

    Full Text Available Abstract Background Despite the clinical outcomes of ovarian stimulation with either GnRH-agonist or GnRH-antagonist analogues for in vitro fertilization (IVF being well analysed, the effect of analogues on oocyte/embryo quality and embryo development is still not known in detail. The aim of this case-control study was to compare the efficacy of a multiple-dose GnRH antagonist protocol with that of the GnRH agonist long protocol with a view to oocyte and embryo quality, embryo development and IVF treatment outcome. Methods Between October 2001 and December 2008, 100 patients were stimulated with human menopausal gonadotrophin (HMG and GnRH antagonist in their first treatment cycle for IVF or intracytoplasmic sperm injection (ICSI. One hundred combined GnRH agonist + HMG (long protocol cycles were matched to the GnRH antagonist + HMG cycles by age, BMI, baseline FSH levels and by cause of infertility. We determined the number and quality of retrieved oocytes, the rate of early-cleavage embryos, the morphology and development of embryos, as well as clinical pregnancy rates. Statistical analysis was performed using Wilcoxon's matched pairs rank sum test and McNemar's chi-square test. P Results The rate of cytoplasmic abnormalities in retrieved oocytes was significantly higher with the use of GnRH antagonist than in GnRH agonist cycles (62.1% vs. 49.9%; P Conclusion Antagonist seemed to influence favourably some parameters of early embryo development dynamics, while other morphological parameters seemed not to be altered according to GnRH analogue used for ovarian stimulation in IVF cycles.

  8. Statistical process control for radiotherapy quality assurance

    International Nuclear Information System (INIS)

    Pawlicki, Todd; Whitaker, Matthew; Boyer, Arthur L.

    2005-01-01

    Every quality assurance process uncovers random and systematic errors. These errors typically consist of many small random errors and a very few number of large errors that dominate the result. Quality assurance practices in radiotherapy do not adequately differentiate between these two sources of error. The ability to separate these types of errors would allow the dominant source(s) of error to be efficiently detected and addressed. In this work, statistical process control is applied to quality assurance in radiotherapy for the purpose of setting action thresholds that differentiate between random and systematic errors. The theoretical development and implementation of process behavior charts are described. We report on a pilot project is which these techniques are applied to daily output and flatness/symmetry quality assurance for a 10 MV photon beam in our department. This clinical case was followed over 52 days. As part of our investigation, we found that action thresholds set using process behavior charts were able to identify systematic changes in our daily quality assurance process. This is in contrast to action thresholds set using the standard deviation, which did not identify the same systematic changes in the process. The process behavior thresholds calculated from a subset of the data detected a 2% change in the process whereas with a standard deviation calculation, no change was detected. Medical physicists must make decisions on quality assurance data as it is acquired. Process behavior charts help decide when to take action and when to acquire more data before making a change in the process

  9. 7 CFR 58.642 - Quality control tests.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Quality control tests. 58.642 Section 58.642... Procedures § 58.642 Quality control tests. All mix ingredients shall be subject to inspection for quality and condition throughout each processing operation. Quality control tests shall be made on flow line samples as...

  10. 7 CFR 58.928 - Quality control tests.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Quality control tests. 58.928 Section 58.928... Procedures § 58.928 Quality control tests. All dairy products and other ingredients shall be subject to inspection for quality and condition throughout each processing operation. Quality control tests shall be...

  11. 7 CFR 58.335 - Quality control tests.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Quality control tests. 58.335 Section 58.335... Procedures § 58.335 Quality control tests. All milk, cream and related products are subject to inspection for quality and condition throughout each processing operation. Quality control tests shall be made on flow...

  12. Internal cost control on the ecological quality of products

    Directory of Open Access Journals (Sweden)

    N.P. Syroid

    2018-04-01

    Full Text Available To improve the environmental quality of products due attention should be paid to control the processes related to environmental quality input of the product. The results of the study help to state the purpose and objectives of the control, also to define objects for internal control of operations cost of environmental quality. So, we believe that the main purpose of internal cost control on the ecological quality of products is the establishment of the correctness and legality of business operations, prevention of violations and abuses in the expenditure of natural, labour, material and financial resources to ensure the minimization of negative impact on the health of consumers and the environment. The basic objectives of internal control of expenditure are brought forward, but it should be noted that they can vary and depend on the size, structure, spheres and types of economic activity of the enterprise, the requirements of management personnel. In the process of identifying the objects of control of environmental quality it should be noted that this list is not exhaustive, but it is most relevant to highlight objects such as genetically modified organisms and waste production. Also the subjects of cost control to environmental quality, their functions and the information base for monitoring are determined. Proper organization of the process of internal cost control on the ecological quality of products would benefit from a clear documentation of transactions, timely and complete registration of accounting data in the registers, the true reflection of information in managerial financial reporting and ensure reduction of the negative impact on the health of consumers and the environment.

  13. Effectiveness of feedback with a smartwatch for high-quality chest compressions during adult cardiac arrest: A randomized controlled simulation study.

    Science.gov (United States)

    Ahn, Chiwon; Lee, Juncheol; Oh, Jaehoon; Song, Yeongtak; Chee, Youngjoon; Lim, Tae Ho; Kang, Hyunggoo; Shin, Hyungoo

    2017-01-01

    Previous studies have demonstrated the potential for using smartwatches with a built-in accelerometer as feedback devices for high-quality chest compression during cardiopulmonary resuscitation. However, to the best of our knowledge, no previous study has reported the effects of this feedback on chest compressions in action. A randomized, parallel controlled study of 40 senior medical students was conducted to examine the effect of chest compression feedback via a smartwatch during cardiopulmonary resuscitation of manikins. A feedback application was developed for the smartwatch, in which visual feedback was provided for chest compression depth and rate. Vibrations from smartwatch were used to indicate the chest compression rate. The participants were randomly allocated to the intervention and control groups, and they performed chest compressions on manikins for 2 min continuously with or without feedback, respectively. The proportion of accurate chest compression depth (≥5 cm and ≤6 cm) was assessed as the primary outcome, and the chest compression depth, chest compression rate, and the proportion of complete chest decompression (≤1 cm of residual leaning) were recorded as secondary outcomes. The proportion of accurate chest compression depth in the intervention group was significantly higher than that in the control group (64.6±7.8% versus 43.1±28.3%; p = 0.02). The mean compression depth and rate and the proportion of complete chest decompressions did not differ significantly between the two groups (all p>0.05). Cardiopulmonary resuscitation-related feedback via a smartwatch could provide assistance with respect to the ideal range of chest compression depth, and this can easily be applied to patients with out-of-hospital arrest by rescuers who wear smartwatches.

  14. Systematic review of quality of life and functional outcomes in randomized placebo-controlled studies of medications for attention-deficit/hyperactivity disorder.

    Science.gov (United States)

    Coghill, David R; Banaschewski, Tobias; Soutullo, César; Cottingham, Matthew G; Zuddas, Alessandro

    2017-11-01

    Children, adolescents and adults with attention-deficit/hyperactivity disorder (ADHD) experience functional impairment and poor health-related quality of life (HRQoL) in addition to symptoms of inattention/hyperactivity-impulsivity. To synthesize qualitatively the published evidence from randomized, double-blind, placebo-controlled trials of the effectiveness of pharmacotherapy on functional impairment or HRQoL in patients with ADHD, a systematic PubMed searching and screening strategy was designed to identify journal articles meeting pre-specified criteria. Post hoc analyses and meta-analyses were excluded. HRQoL outcomes, functional outcomes and the principal ADHD symptom-based outcome were extracted from included studies. An effect size of 0.5 versus placebo was used as a threshold for potential clinical relevance (unreported effect sizes were calculated when possible). Of 291 records screened, 35 articles describing 34 studies were included. HRQoL/functioning was usually self-rated in adults and proxy-rated in children/adolescents. Baseline data indicated substantial HRQoL deficits in children/adolescents. Placebo-adjusted effects of medication on ADHD symptoms, HRQoL and functioning, respectively, were statistically or nominally significant in 18/18, 10/12 and 7/9 studies in children/adolescents and 14/16, 9/11 and 9/10 studies in adults. Effect sizes were ≥0.5 versus placebo for symptoms, HRQoL and functioning, respectively, in 14/16, 7/9 and 4/8 studies in children/adolescents; and 6/12, 1/6 and 1/8 studies in adults. Effect sizes were typically larger for stimulants than for non-stimulants, for symptoms than for HRQoL/functioning, and for children/adolescents than for adults. The efficacy of ADHD medication extends beyond symptom control and may help reduce the related but distinct functional impairments and HRQoL deficits in patients with ADHD.

  15. Quality Management of CERN Vacuum Controls

    CERN Document Server

    Antoniotti, F; Fortescue-Beck, E; Gama, J; Gomes, P; Le Roux, P; Pereira, H; Pigny, G

    2014-01-01

    The vacuum controls Section (TE-VSC-ICM) is in charge of the monitoring, maintenance and consolidation of the control systems of all accelerators and detectors in CERN; this represents 6 000 instruments distributed along 128 km of vacuum chambers, often of heterogeneous architectures and of diverse technical generations. In order to improve the efficiency of the services provided by ICM, to vacuum experts and to accelerator operators, a Quality Management Plan is being put into place. The first step was the standardization of the naming convention across different accelerators. The traceability of problems, requests, repairs, and other actions, has also been put into place (VTL). This was combined with the effort to identify each individual device by a coded label, and register it in a central database (MTF). Occurring in parallel, was the gathering of old documents and the centralization of information concerning architectures, procedures, equipment and settings (EDMS). To describe the topology of control c...

  16. A Randomized Control Study on Psycho-Education Group on Improving Health-Related Quality of Life of Chinese Persons with Major Neurocognitive Disorder.

    Science.gov (United States)

    Young, Kim-Wan

    2016-01-01

    People with a major neurocognitive disorder (PwND) are found to have a lower health related quality of life (HRQoL) than those without neurocognitive disorder. This research study aims to evaluate the effectiveness of a psycho-education group in improving the HRQoL of Chinese PwND. By adopting randomized control trial (RCT), Chinese PwND were randomly assigned to either a 10-session psycho-education group or the control group. Family caregivers of treatment group were encouraged to take part in two sessions focusing on the caring and communication skills. Control group and their family caregivers received standardized educational materials on basic information on neurocognitive disorder for them to read at home. Standardized assessment was conducted both with PwND and their caregivers independently to give the self-rated and caregiver-rated HRQoL of PwND in the pre- and post- treatment periods by a research assistant who was blind to the group assignment of the participants. Moreover, qualitative interviews were also conducted for ten participants and five family caregivers of the treatment group to identify those group elements relating to its effectiveness. 2 × 2 repeated measures ANCOVA demonstrated that the treatment group (n = 32) was significantly more effective than the control group (n = 32) in improving the caregiver-rated HRQoL (F[1, 61] = 4.35, p = .04 psycho-education group significantly improves caregiver-rated HRQoL of PwND, supporting the feasibility and effectiveness of the psycho-education group.

  17. The effect of impedance-controlled robotic gait training on walking ability and quality in individuals with chronic incomplete spinal cord injury: an explorative study.

    Science.gov (United States)

    Fleerkotte, Bertine M; Koopman, Bram; Buurke, Jaap H; van Asseldonk, Edwin H F; van der Kooij, Herman; Rietman, Johan S

    2014-03-04

    There is increasing interest in the use of robotic gait-training devices in walking rehabilitation of incomplete spinal cord injured (iSCI) individuals. These devices provide promising opportunities to increase the intensity of training and reduce physical demands on therapists. Despite these potential benefits, robotic gait-training devices have not yet demonstrated clear advantages over conventional gait-training approaches, in terms of functional outcomes. This might be due to the reduced active participation and step-to-step variability in most robotic gait-training strategies, when compared to manually assisted therapy. Impedance-controlled devices can increase active participation and step-to-step variability. The aim of this study was to assess the effect of impedance-controlled robotic gait training on walking ability and quality in chronic iSCI individuals. A group of 10 individuals with chronic iSCI participated in an explorative clinical trial. Participants trained three times a week for eight weeks using an impedance-controlled robotic gait trainer (LOPES: LOwer extremity Powered ExoSkeleton). Primary outcomes were the 10-meter walking test (10 MWT), the Walking Index for Spinal Cord Injury (WISCI II), the six-meter walking test (6 MWT), the Timed Up and Go test (TUG) and the Lower Extremity Motor Scores (LEMS). Secondary outcomes were spatiotemporal and kinematics measures. All participants were tested before, during, and after training and at 8 weeks follow-up. Participants experienced significant improvements in walking speed (0.06 m/s, p = 0.008), distance (29 m, p = 0.005), TUG (3.4 s, p = 0.012), LEMS (3.4, p = 0.017) and WISCI after eight weeks of training with LOPES. At the eight-week follow-up, participants retained the improvements measured at the end of the training period. Significant improvements were also found in spatiotemporal measures and hip range of motion. Robotic gait training using an impedance-controlled robot is feasible in gait

  18. Microbiological quality control practices at Australian Radioisotopes

    International Nuclear Information System (INIS)

    Saunders, M.

    1987-01-01

    As a domestic manufacturer of therapeutic substances, Australian Radioisotopes (ARI) must adhere to guidelines set out by the Commonwealth Department of Health in the Code of Good Manufacturing Practices for Therapeutic Goods 1983 (GMP). The GMP gives guidelines for staff training, building requirements, sanitation, documentation and quality control practices. These guidelines form the basis for regular audits performed by officers of the National Biological Standards Laboratories. At Lucas Heights, ARI has combined the principles of the GMP with the overriding precautions introduced for environmental and staff safety and protection. Its policy is to maintain a high level of quality assurance for product identity, purity and sterility and apyrogenicity during all stages of product manufacture

  19. Basic quality control in diagnostic radiology

    International Nuclear Information System (INIS)

    Wikstrom, Erik

    2016-01-01

    Along the route toward regular performance of Quality Control in the Diagnostic Imaging sector there are a number of balances to negotiate: Patient/Staff safety considerations vs Regulatory compliance vs Performance of modern equipment vs Clinic's Productivity. At first glance these ambitions may seem in conflict. The tests performed to meet regulatory requirements may or may not bear any semblance to real clinical measurement scenarios. And the process of collecting the data from the quality assurance tests may induce a system down- time that adversely affects the clinic's overall productivity. Furthermore, the time it takes to complete the analysis of the test data and provide the report required to take the facility back into operation is time wasted for patients waiting for a diagnostic imaging exam

  20. Omalizumab Improves Quality of Life and Asthma Control in Chinese Patients With Moderate to Severe Asthma: A Randomized Phase III Study

    Science.gov (United States)

    Li, Jing; Kang, Jian; Wang, Changzheng; Yang, Jing; Wang, Linda; Kottakis, Ioannis; Humphries, Michael

    2016-01-01

    Purpose Omalizumab is the preferred add-on therapy for patients with moderate-to-severe persistent allergic asthma and has demonstrated efficacy and safety in various ethnicities. This study evaluated the efficacy and safety of omalizumab in Chinese patients with moderate-to-severe allergic asthma. Methods This randomized, double-blind, parallel-group, placebo-controlled, phase III study assessed lung function, quality of life, asthma control, and safety of omalizumab after 24-week therapy in Chinese patients (18-75 years of age). Results A total of 616 patients were randomized (1:1) to omalizumab or placebo. The primary endpoint, least squares mean treatment difference (LSM-TD) in morning peak expiratory flow (PEF) (omalizumab vs placebo), at Weeks >20-24 was 8.85 L/min (Full analysis set; P=0.062). Per-protocol analysis set showed significant improvements with LSM-TD of 11.53 L/min in mean mPEF at Weeks >20-24 (P=0.022). The FEV1 % predicted was significantly improved with omalizumab vs placebo from 8 to 24 weeks (after 24-week treatment: LSM-TD=4.12%; P=0.001). At Week 24, a higher proportion of omalizumab-treated patients achieved clinically relevant improvements in standardized AQLQ (58.2% vs 39.3%; LSM=0.51 vs 0.10; Pquality of life, and asthma control in Chinese patients with moderate-to-severe persistent allergic asthma and has a good safety profile. PMID:27126725

  1. Express quality control of chicken eggs by machine vision

    Science.gov (United States)

    Gorbunova, Elena V.; Chertov, Aleksandr N.; Peretyagin, Vladimir S.; Korotaev, Valery V.; Arbuzova, Evgeniia A.

    2017-06-01

    The urgency of the task of analyzing the foodstuffs quality is determined by the strategy for the formation of a healthy lifestyle and the rational nutrition of the world population. This applies to products, such as chicken eggs. In particular, it is necessary to control the chicken eggs quality at the farm production prior to incubation in order to eliminate the possible hereditary diseases, as well as high embryonic mortality and a sharp decrease in the quality of the bred young. Up to this day, in the market there are no objective instruments of contactless express quality control as analytical equipment that allow the high-precision quality examination of the chicken eggs, which is determined by the color parameters of the eggshell (color uniformity) and yolk of eggs, and by the presence in the eggshell of various defects (cracks, growths, wrinkles, dirty). All mentioned features are usually evaluated only visually (subjectively) with the help of normalized color standards and ovoscopes. Therefore, this work is devoted to the investigation of the application opportunities of contactless express control method with the help of technical vision to implement the chicken eggs' quality analysis. As a result of the studies, a prototype with the appropriate software was proposed. Experimental studies of this equipment on a representative sample of eggs from chickens of different breeds have been carried out (the total number of analyzed samples exceeds 300 pieces). The correctness of the color analysis was verified by spectrophotometric studies of the surface of the eggshell.

  2. Engaging staff to improve quality and safety in an austere medical environment: a case-control study in two Sierra Leonean hospitals.

    Science.gov (United States)

    Rosen, Michael A; Chima, Adaora M; Sampson, John B; Jackson, Eric V; Koka, Rahul; Marx, Megan K; Kamara, Thaim B; Ogbuagu, Onyebuchi U; Lee, Benjamin H

    2015-08-01

    Inadequate observance of basic processes in patient care such as patient monitoring and documentation practices are potential impediments to the timely diagnoses and management of patients. These gaps exist in low resource settings such as Sierra Leone and can be attributed to a myriad of factors such as workforce and technology deficiencies. In the study site, only 12.4% of four critical vital signs were documented in the pre-intervention period. Implement a failure mode and effects analysis (FMEA) to improve documentation of four patient vital signs: temperature, blood pressure, pulse rate and respiratory rate. FMEA was implemented among a subpopulation of health workers who are involved in monitoring and documenting patient vital signs. Pre- and post-FMEA monitoring and documentation practice were compared with a control site. Participants identified a four-step process to monitoring and documenting vital signs, three categories of failure modes and four potential solutions. Based on 2100 patient days of documentation compliance data from 147 patients between July and November 2012, staff members at the study site were 1.79 times more likely to document all four patient vital signs in the post-implementation period (95% CI [1.35, 2.38]). FMEA is a feasible and effective strategy for improving quality and safety in an austere medical environment. Documentation compliance improved at the intervention facility. To evaluate the scalability and sustainability of this approach, programs targeting the development of these types of process improvement skills in local staff should be evaluated. © The Author 2015. Published by Oxford University Press in association with the International Society for Quality in Health Care; all rights reserved.

  3. ANALYSIS OF QUALITY COSTS FOR STATISTICA QUALITY CONTROL PLANNING

    Directory of Open Access Journals (Sweden)

    N. Chiadamrong

    2017-12-01

    Full Text Available Quality has become one or the most important force leading to organizational success and company growth in national and international markets. The return-on-investment from strong and effective quality programs is providing excellent profitability results in firms with effective quality strategies. Due to the wide variation in quality results, the search for the genuine keys to success in quality has become a matter of deep concern to management of companies. This paper suggests a way to quantifying quality costs. As a result, the appropriate quality strategies can be adjusted and set to match with each company situation based on the categorization of the quality costs suggested. This outcome can, then, be used as a guideline for manufactures in setting their suitable quality program, which establishes the proper balance between the costs and customer services.

  4. 40 CFR 75.21 - Quality assurance and quality control requirements.

    Science.gov (United States)

    2010-07-01

    ... quality assurance audit or any other audit, the system is out-of-control. The owner or operator shall... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Quality assurance and quality control... assurance and quality control requirements. (a) Continuous emission monitoring systems. The owner or...

  5. Report on the quality control study NAT-7 for the determination of trace and minor elements in dust artificially loaded on air filters

    International Nuclear Information System (INIS)

    Bleise, A.; Smodis, A.

    2002-02-01

    A quality control study was organized on two air filters artificially loaded with urban dust. One dust material was collected from the air intake ducts of the Vienna General Hospital, the second material was collected from the main ventilation shaft of a road tunnel in Prague. 49 laboratories from 40 countries participated in the study, providing 53 sets of results. The following analytical methods were used: neutron activation analysis (NAA), inductive coupled plasma atomic emission spectrometry (ICP-AES), inductively coupled plasma mass spectrometry (ICP-MS), particle induced X-ray emission spectrometry (PDCE), atomic absorption spectrometry (AAS), and X-ray fluorescence spectrometry (XRF). The results were evaluated following the standard LEA procedures for (1) an interlaboratory comparison exercise and (2) a proficiency test using established target values. For the air filter sample V, 754 laboratory mean values for 38 elements were reported. More than 4 mean values were obtained for 26 measurands and these were statistically evaluated. Only 10 % 71 values) of the results were detected as outliers by the statistical data evaluation. The results and statistical parameters are listed in the appendices I and II. The results were also evaluated as a proficiency test using established target values. Precision and accuracy criteria were applied to 15 elements. 534 laboratory mean values were reported for those elements, 114 values (20%) did not pass the set proficiency test criteria. The individual laboratory results are listed in appendix IV. For the air filter sample P, 694 laboratory mean values for 38 elements were reported. More than 4 mean values were obtained for 26 measurands and these were statistically evaluated. Only 9% (60 values) of the results were detected as outliers by the statistical data evaluation. The results and statistical parameters are listed in the appendices I and II. The results were also evaluated as a proficiency test using target values

  6. Dosimetric study for characterization of a postal system of quality control in brachytherapy; Estudo dosimetrico para caracterizacao de um sistema postal de controle de qualidade em braquiterapia

    Energy Technology Data Exchange (ETDEWEB)

    Alves, Victor Gabriel Leandro, E-mail: vgalves@inca.gov.b [Instituto Nacional do Cancer (INCa), Rio de Janeiro, RJ (Brazil); Queiroz Filho, Pedro Pacheco de; Santos, Denison de Souza, E-mail: queiroz@ird.gov.b, E-mail: santosd@ird.gov.b [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Begalli, Marcia, E-mail: begalli@uerj.b [Universidade do Estado do Rio de Janeiro (IF/UERJ), RJ (Brazil). Inst. de Fisica

    2009-07-01

    This work presents a dosimetric study of a postal system, to be developed for measurements of brachytherapy. It was projected a PMMA phantom with orifices for insertion of the high dose {sup 192}Ir source and the T L dosemeters. The system was characterized with using of Monte Carlo simulations, using the dosimetric magnitudes defined at the T G-43 of AAPM, as function of radial dose g(f)

  7. Quality control in quantitative computed tomography

    International Nuclear Information System (INIS)

    Jessen, K.A.; Joergensen, J.

    1989-01-01

    Computed tomography (CT) has for several years been an indispensable tool in diagnostic radiology, but it is only recently that extraction of quantitative information from CT images has been of practical clinical value. Only careful control of the scan parameters, and especially the scan geometry, allows useful information to be obtained; and it can be demonstrated by simple phantom measurements how sensitive a CT system can be to variations in size, shape and position of the phantom in the gantry aperture. Significant differences exist between systems that are not manifested in normal control of image quality and general performance tests. Therefore an actual system has to be analysed for its suitability for quantitative use of the images before critical clinical applications are justified. (author)

  8. Quality control concept for radioactive waste packages

    International Nuclear Information System (INIS)

    Warnecke, E.; Martens, B.R.; Odoj, R.

    1990-01-01

    In the Federal Republic of Germany a contract with the BfS for the performance of quality control measures is necessary. It is principally possible to apply two alternative methods: random checks on waste packages or qualification of conditioning processes with subsequent inspections. Priority is given to the control by the process qualification. Both methods have successfully been developed in the Federal Republic of Germany and can be applied. In the course of the qualification of conditioning processes it must be demonstrated by inactive and/or active runs that waste packages are produced which fulfil the waste acceptance requirements. The qualification results in the fixation of a handbook for the operation of the respective conditioning process including the process instrumentation and the operational margins. The qualified process will be inspected to assure the compliance of the actual operation with the conditions fixed in the handbook. (orig./DG)

  9. Software Quality Control at Belle II

    Science.gov (United States)

    Ritter, M.; Kuhr, T.; Hauth, T.; Gebard, T.; Kristof, M.; Pulvermacher, C.; Belle Software Group, II

    2017-10-01

    Over the last seven years the software stack of the next generation B factory experiment Belle II has grown to over one million lines of C++ and Python code, counting only the part included in offline software releases. There are several thousand commits to the central repository by about 100 individual developers per year. To keep a coherent software stack of high quality that it can be sustained and used efficiently for data acquisition, simulation, reconstruction, and analysis over the lifetime of the Belle II experiment is a challenge. A set of tools is employed to monitor the quality of the software and provide fast feedback to the developers. They are integrated in a machinery that is controlled by a buildbot master and automates the quality checks. The tools include different compilers, cppcheck, the clang static analyzer, valgrind memcheck, doxygen, a geometry overlap checker, a check for missing or extra library links, unit tests, steering file level tests, a sophisticated high-level validation suite, and an issue tracker. The technological development infrastructure is complemented by organizational means to coordinate the development.

  10. Quality control of nuclear medicine instruments

    International Nuclear Information System (INIS)

    1984-11-01

    This document, which gives detailed guidance on the quality control of the various electronic instruments used for radiation detection and measurement in nuclear medicine, stems from the work of two Advisory Groups convened by the International Atomic Energy Agency (IAEA). A preliminary document, including recommended test schedules but lacking actual protocols for the tests, was drawn up by the first of these groups, meeting at the IAEA Headquarters in Vienna in 1979. A revised and extended version, incorporating recommended test protocols, was prepared by the second Group, meeting likewise in Vienna in 1982. This version is the model for the present text. The document should be of value to all nuclear medicine units, and especially to those in developing countries, in the initiation or revision of schemes for the quality control of their instruments. Its recommendations have provided the basis for instruction in two IAEA regional technical co-operation projects in the subject field, one initiated in 1981 for countries of Latin America and one initiated in 1982 for countries of Asia and the Pacific

  11. Clinical aspects of foot health and their influence on quality of life among breast cancer survivors: a case–control study

    Directory of Open Access Journals (Sweden)

    Palomo-López P

    2017-11-01

    Full Text Available Patricia Palomo-López,1 David Rodríguez-Sanz,2 Ricardo Becerro-de-Bengoa-Vallejo,3 Marta Elena Losa-Iglesias,4 Jorge Guerrero-Martín,5 Cesar Calvo-Lobo,6 Daniel López-López7 1Department of Nursing, University Center of Plasencia, University of Extremadura, 2Department of Physical Therapy and Podiatry, Physical Therapy and Health Sciences, Research Group, Universidad Europea de Madrid, Madrid, 3School of Nursing, Physiotherapy and Podiatry, University Complutense of Madrid, 4Faculty of Health Sciences, University Rey Juan Carlos, 5Department of Nursing, Faculty of Medicine, Badajoz. University of Extremadura, 6Nursing and Physical Therapy Department, Institute of Biomedicine (IBIOMED, Universidad de León, Ponferrada, León, 7Research, Health and Podiatry Unit, Department of Health Sciences, Faculty of Nursing and Podiatry, Universidade da Coruña, Spain Purpose: The aim of this study was to analyze and compare foot health and general health in a sample of women divided into two groups: 1 those with breast cancer and undergoing chemotherapy treatment and 2 healthy women without breast cancer and with normalized reference values.Methods: A case–control observational study was performed. Two-hundred women with a mean age of 51.00±8.75 years were recruited from podiatric medicine and surgery clinics from the University of Extremadura (Plasencia, Spain and the Hospital Infanta Cristina (Badajoz, Spain. The women were divided into case and control groups (undergoing chemotherapy treatment and healthy women, respectively. The Foot Health Status Questionnaire was used to assess foot health domain scores.Results: Significant differences between both groups were seen for foot pain (P=0.003, foot function (P<0.001, physical activity (P<0.001, social capacity (P<0.001, and vigor (P=0.001. The remaining domains (footwear, general health, and foot health did not show significant differences between the two groups (P≥0.01.Conclusion: Women with

  12. Quality control of radioiodinated gastrin for radioimmunoassay

    International Nuclear Information System (INIS)

    Ginabreda, M.G.P.; Borghi, V.C.; Bettarello, A.

    1988-07-01

    Radioiodinated human gastrin has been prepared at IPEN laboratory for radioimmunoassay use. This work developed the quality control of this tracer analyzing parameters of the labelling reaction, chromatographic purification and radioimmunoassay. The radioiodination yield obtained in five experiments was reproducible and similar when analyzed on 7% polyaraylamide gel eletrophoresis - PAGE - (mean + - SD of 51.70 + - 10.76%) and by1 25 I incorporation checked through thrichloroacetic acid precipitation - TCA - (57-36 + - 9.69%). Similary, after purification the labelled gastrin revaled high and reproducible purity degree when submitted to PAGE (96.57 + - 1.06%) and CA (94.82 + - 4.20%) analysis. The respective specific activities varied from 62 to 307 uCi/ug, being determined by the self-displacement method, which is based on the immunoactivity of the tracer. In this way, the antibody titers required to bind 50% of the tracer ranged from 1:32.000 to 1:180.000. Consequently, the respective doses producing 50% fall in the maximum response of the radioimmunoassays ranged from 155.0 to 24.0 pmol/1, but remained unchanged for each tracer even after three months of its preparations. The tracers presented very low non-specific binding values (1.78 + - 0.79%), stablespecific binding values (46.49 + - 5.65%) and a good between-assay precision, evaluated by an internal quality control sample (25.71 + - 4.30%) with coefficient of variation of 16.74%). The PAGE analysis of the unlabeled gastrin used in the first and last radioiodination revealed an unique and unaltered component, confirming the quality of the tracers. (author) [pt

  13. Internal quality control of neutron activation analysis laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Kim, S. H.; Mun, J. H.; BaeK, S. Y.; Jung, Y. S.; Kim, Y. J. [KAERI, Taejon (Korea, Republic of)

    2004-07-01

    The importance for quality assurance and control in analytical laboratories has been emphasized, day by day. Internal quality control using certified reference materials(CRMs) can be one of effective methods for this purpose. In this study, 10 kinds of CRMs consisting of soil, sediment and biological matrix were analyzed. To evaluate the confidence of analytical results and the validation of testing method and procedure, the accuracy and the precision of the measured elements were treated statistically and the reproducibility was compared with those values produced before 2003.

  14. The effects of a common stainless steel orthodontic bracket on the diagnostic quality of cranial and cervical 3T- MR images: a prospective, case-control study.

    Science.gov (United States)

    Cassetta, Michele; Pranno, Nicola; Stasolla, Alessandro; Orsogna, Nicola; Fierro, Davide; Cavallini, Costanza; Cantisani, Vito

    2017-08-01

    To evaluate the effect of orthodontic stainless steel brackets and two different types of archwires on the diagnostic quality of 3-T MR images. This prospective, case-control study was conducted following Strengthening the Reporting of Observational Studies in Epidemiology guidelines. The recruitment was conducted among orthodontic patients. 80 subjects, requiring MRI for the presence of temporomandibular disorders, were enrolled and divided into four groups: 20 patients using aligners (control group); 20 patients with stainless steel brackets without archwires; 20 patients with stainless steel brackets and nickel-titanium archwires; and 20 patients with stainless steel brackets and stainless steel archwires. Two experts in neuroradiology evaluated the images to determine the amount of distortion in 6 regions and 48 districts. A score was subjectively assigned according to a modified receiver operating characteristic method of distortion classification. Any disagreement was resolved through consensus seeking; when this was not possible, a third neuroradiologist was consulted. The following statistical methods were used: descriptive statistics, Cohen's kappa coefficient (k), Kruskal-Wallis test, pairwise comparisons using the Dunn-Bonferroni approach. The significance was set at p ≤ 0.05. The presence of stainless steel brackets with or without archwires negatively influenced MRI of the cervical region, paranasal sinuses, head and neck region, and cervical vertebrae but did not influence MRI of brain and temporomandibular joint regions. Patients with a stainless steel multibracket orthodontic appliance should remove it before cervical vertebrae, cervical region, paranasal sinuses, and head and neck MRI scans. The brain and temporomandibular joint region MRI should not require the removal of such appliances.

  15. 7 CFR 58.141 - Alternate quality control program.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Alternate quality control program. 58.141 Section 58... Service 1 Quality Specifications for Raw Milk § 58.141 Alternate quality control program. When a plant has in operation an acceptable quality program, at the producer level, which is approved by the...

  16. Technology requirement for Halal quality control | Husny | Journal of ...

    African Journals Online (AJOL)

    Technology requirement for Halal quality control. ... Findings show that each industry segments have different technology characteristics preference. ... Keywords: halal industry, quality control; technology assistance; food and beverage; ...

  17. RAndomised controlled trial to imProve depressIon and the quality of life of people with Dementia using cognitive bias modification: RAPID study protocol.

    Science.gov (United States)

    Almeida, Osvaldo P; MacLeod, Colin; Flicker, Leon; Ford, Andrew; Grafton, Ben; Etherton-Beer, Christopher

    2014-07-23

    Depressive symptoms are common and undermine the quality of life of people with Alzheimer's disease (AD). Cholinesterase inhibitors and antidepressants have all but no effect on the mood of patients, and their use increases adverse events. Cognitive bias modification (CBM) targets attentional and interpretative biases associated with anxiety, dysphoria and depression and may be useful to treat depression in AD (DAD). This trial aims to determine the effect of CBM on depression scores and the quality of life of people with DAD. Randomised, double-blind, parallel, controlled trial of CBM (1:1 allocation ratio). Participants will be 80 adults with probable AD living in the Western Australian community who score 8 or more on the Cornell Scale for Depression in Dementia (CSDD). They will have mild to moderate dementia (Mini-Mental State Examination-MMSE score ≥15) and will be free of severe sensory impairment or suicidal intent. The intervention will consist of 10 40 min sessions of CBM delivered over 2 weeks using a high-resolution monitor using a local computer station at the Western Australian Centre for Health and Ageing. The primary outcomes of interest are the 2-week change, from baseline, in the severity of CSDD scores and the Quality of Life AD (QoL-AD) scores. Secondary outcomes include changes in the CSDD, QoL-AD after 12 weeks, and changes in MMSE scores, negative attentional and interpretative bias and the proportion of participants with CSDD principles of the Declaration of Helsinki and participants will provide written informed consent. The Ethics Committee of the Royal Perth Hospital will approve and oversee the study (REG14-036). The results of this trial will provide level 2 evidence of efficacy for CBM as a treatment of DAD. Australian and New Zealand Clinical Trials Registry number ACTRN12614000420640, date registered 06/04/2014. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence

  18. Development and prospective evaluation of an automated software system for quality control of quantitative 99mTc-MAG3 renal studies.

    Science.gov (United States)

    Folks, Russell D; Garcia, Ernest V; Taylor, Andrew T

    2007-03-01

    Quantitative nuclear renography has numerous potential sources of error. We previously reported the initial development of a computer software module for comprehensively addressing the issue of quality control (QC) in the analysis of radionuclide renal images. The objective of this study was to prospectively test the QC software. The QC software works in conjunction with standard quantitative renal image analysis using a renal quantification program. The software saves a text file that summarizes QC findings as possible errors in user-entered values, calculated values that may be unreliable because of the patient's clinical condition, and problems relating to acquisition or processing. To test the QC software, a technologist not involved in software development processed 83 consecutive nontransplant clinical studies. The QC findings of the software were then tabulated. QC events were defined as technical (study descriptors that were out of range or were entered and then changed, unusually sized or positioned regions of interest, or missing frames in the dynamic image set) or clinical (calculated functional values judged to be erroneous or unreliable). Technical QC events were identified in 36 (43%) of 83 studies. Clinical QC events were identified in 37 (45%) of 83 studies. Specific QC events included starting the camera after the bolus had reached the kidney, dose infiltration, oversubtraction of background activity, and missing frames in the dynamic image set. QC software has been developed to automatically verify user input, monitor calculation of renal functional parameters, summarize QC findings, and flag potentially unreliable values for the nuclear medicine physician. Incorporation of automated QC features into commercial or local renal software can reduce errors and improve technologist performance and should improve the efficiency and accuracy of image interpretation.

  19. Challenges in setting up quality control in diagnostic radiology ...

    African Journals Online (AJOL)

    Journal Home > Vol 24, No 4 (2015) >. Log in or ... Quality control (QC) on diagnostic radiology equipment form part of the fundamental requirements for the ... Inadequate cooperation by facilities management, lack of QC equipment and insufficient staff form the major challenges in setting up QC in the facilities under study.

  20. Determination of dilution and quality control of total and anti ...

    African Journals Online (AJOL)

    Objective: To determine the correct dilution and Quality control commercial ELISA of total and anti-measles antibodies for HIV infected pregnant women. Design: A laboratory based study. Setting: The University of Nairobi, Department of Paediatrics laboratory. Subjects: HIV infected pregnant women enrolled and exposed to ...

  1. Monitoring Leptospira strain collections: the need for quality control

    NARCIS (Netherlands)

    Cerqueira, Gustavo M.; McBride, Alan J. A.; Queiroz, Adriano; Pinto, Luciano S.; Silva, Everton F.; Hartskeerl, Rudy A.; Reis, Mitermayer G.; Ko, Albert I.; Dellagostin, Odir A.

    2010-01-01

    The purpose of this study was to perform a 16S sequence-based quality control of two Leptospira strain collections. 16S rRNA gene sequencing was used to verify two Leptospira reference collections provided by the World Health Organization and maintained at a reference laboratory for leptospirosis in

  2. Satisfaction monitoring for quality control in campground management

    Science.gov (United States)

    Wilbur F. LaPage; Malcolm I. Bevins

    1981-01-01

    A 4-year study of camper satisfaction indicates that satisfaction monitoring is a useful tool for campground managers to assess their performance and achieve a high level of quality control in their service to the public. An indication of camper satisfaction with campground management is gained from a report card on which a small sample of visitors rates 14 elements of...

  3. Ensuring quality control of forensic accounting for efficient and ...

    African Journals Online (AJOL)

    This study focuses on ensuring quality control of forensic accounting for efficient and effective corporate management. Over the years, fraud has taken the center stage in every discussion whether in business or social. “3m” have been identified to be the tool used to effect this crime namely; misappropriation, misapplication ...

  4. Quality control for retinal OCT in multiple sclerosis

    DEFF Research Database (Denmark)

    Schippling, S; Balk, Lj; Costello, F

    2015-01-01

    to provide guidance on the use of validated quality control (QC) criteria for the use of OCT in MS research and clinical trials. METHODS: A prospective multi-centre (n = 13) study. Peripapillary ring scan QC rating of an OCT training set (n = 50) was followed by a test set (n = 50). Inter-rater agreement...

  5. Association of adherence to epilepsy quality standards with seizure control.

    Science.gov (United States)

    Moura, Lidia M V R; Mendez, Diego Yacaman; Jesus, Jonathan De; Andrade, Rogger A; Weissman, Joel S; Vickrey, Barbara G; Hoch, Daniel B

    2015-11-01

    We assessed the relationship between adherence to epilepsy quality measures (EQM) and seizure control over 2-3 years in a retrospective cohort study. 6150 patients were identified at two large academic medical centers with a primary or secondary diagnosis of epilepsy, were 18-85 years old and seen in outpatient general neurology or epilepsy units between June 2011 and May 2014. Patients were included if: their initial visit was between June 2011 and June 2012, treatment was with ≥1 anti-seizure drug, there was ≥1 visit per year during the timeframe, and seizure frequency was documented at initial and final visits, yielding 162 patients/1055 visits from which socio-demographic, clinical and care quality data were abstracted. Quality care was assessed as (1) percent adherence to up to 8 eligible EQM, and (2) defect-free care (DFC: adherence to all eligible EQM). Seizure control (SC) was defined as ≥50% reduction in average seizures/month between initial and final visits. Chi-square and t-test compared care quality with seizure control. Logistic regression was used to assess the relationships between SC, quality of care and subspecialist involvement. Care quality, reflected by documentation of seizure frequency, addressing therapeutic interventions, and referral to a comprehensive epilepsy center, all exceeded 80% adherence. Care quality as reflected by documentation of seizure type, etiology or syndrome; assessment of side effects, counseling about epilepsy safety and women's issues, and screening for psychiatric disorders ranged from 40 to 57%. Mean EQM adherence across all applicable measures was associated with greater seizure control (p=0.0098). DFC was low (=8%) and did not covary with seizure control (p=0.55). The SC and non-SC groups only differed on epilepsy etiology (p=0.04). Exploratory analysis showed that mean quality scores are associated with seizure control (OR=4.9 [1.3-18.5], p=0.017) while controlling for the effect of subspecialty involvement

  6. Managing Air Quality - Control Strategies to Achieve Air Pollution Reduction

    Science.gov (United States)

    Considerations in designing an effective control strategy related to air quality, controlling pollution sources, need for regional or national controls, steps to developing a control strategy, and additional EPA resources.

  7. 10 CFR 26.137 - Quality assurance and quality control.

    Science.gov (United States)

    2010-01-01

    ... cutoff concentration for the compound of interest, a control without the compound of interest (i.e., a certified negative control), and a control with at least one of the compounds of interest at a measurable... calibrator, a control without the compound of interest (i.e., a certified negative control), and a control...

  8. Quality control of parasitology stool examination in Tabriz clinical laboratories

    Directory of Open Access Journals (Sweden)

    shahram Khademvatan

    2011-06-01

    Full Text Available The purpose of quality control program was to make doctors and laboratory personnel trust in laboratory results and consequently increasing confidence in laboratory achievements. The quality assurance means raising the level of quality in all tests that lead to raising the level of work efficiency and laboratories including minimum expense for society and minimum time for lab personnel. This study aimed to assess and determine the accuracy and precision of results in Tabriz medical diagnostic laboratories. Materials and Methods: In this retrospective study, 790 stool samples were selected randomly and tested by standard methods.Student t- test, SPSS software and sensitivity and accuracy formulas were used for data analysis. Results: The sensitivity was 62%, 22% and 8% with 95% confidence intervals for worm's eggs, protozoan cysts and trophozoite detection respectively. Conclusion: To elevate quality assurance in clinical diagnostic laboratory, monitoring and check of the laboratories by standard methods continually should be done.

  9. Evaluation of quality control of radiopharmaceuticals in Nuclear Medicine service

    International Nuclear Information System (INIS)

    Tavares, Jamille A. Lopes; Lira, Renata F. de; Santos, Marcus Aurelio P. dos

    2014-01-01

    Radiopharmaceuticals are a type of pharmaceutical preparation associated with radionuclides with purpose of diagnosis and therapy. Nuclear Medicine Services (NMS) should perform quality control of radiopharmaceuticals according to the recommendations of the manufacturer and scientific evidences accepted by the National Agency Sanitary Surveillance ( Brazilian ANVISA). This study evaluated the quality of the main radiopharmaceuticals in a NMS of the state of Pernambuco in relation to pH and radiochemical purity. The results showed that 96.8% of the radiopharmaceuticals showed radiochemical purity and all pH values were within the range recommended by the American pharmacopoeia. The study found that the quality control when inserted into the NMS, provides important data that allows exclusion of radiopharmaceuticals with low radiochemistry purity, favoring a reliable diagnosis and ensuring good radiation protection practices and biosecurity for patient and occupationally exposed individuals

  10. Micro-homogeneity of candidate reference materials: Results from an intercomparison study for the Analytical Quality Control Services (AQCS) of the IAEA

    International Nuclear Information System (INIS)

    Rossbach, M.; Kniewald, G.

    2002-01-01

    The IAEA Analytical Quality Control Services (AQCS) has made available two single cell algae materials IAEA-392 and IAEA-393 as well as an urban dust IAEA-396 to study their use for analytical sample sizes in the milligram range and below. Micro-analytical techniques such as PIXE and μ-PIXE, solid sampling AAS, scanning electron microprobe X-ray analysis and INAA were applied to the determination of trace elements on the basis of μg to mg amounts of the selected materials. The comparability of the mean values as well as the reproducibility of successive measurements is being evaluated in order to compare relative homogeneity factors for many elements in the investigated materials. From the reported results it seems that the algae materials IAEA-392 and IAEA-393 are extremely homogeneous biological materials for a number of elements with an extraordinary sharp particle size distribution below 10 μm. A similar situation seems to hold for the urban dust material IAEA-396 which had been air-jet milled to a particle size distribution around 4 μm. The introduction of these materials as CRMs with very small amounts needed to determine the certified concentrations will help to meet the needs of micro-analytical techniques for natural matrix reference materials. (author)

  11. Quality of life and trust among young people with narcolepsy and their families, after the Pandemrix® vaccination: protocol for a case-control study.

    Science.gov (United States)

    Blomberg, Karin; Carlsson, Agneta Anderzén; Hagberg, Lars; Jonsson, Östen; Leissner, Lena; Eriksson, Mats H

    2017-08-23

    The extensive vaccination programme against swine flu resulted in an increased incidence of narcolepsy among children and adolescents. There is a need to explore if these young persons' experiences have affected their trust in healthcare, their willingness to participate in future prevention programmes, and their contacts with the healthcare system. The overall aim is to identify factors important for the life-situation of children and adolescents with narcolepsy and their families, and factors that correlate with trust in healthcare. Data will be collected via questionnaires from all available children with narcolepsy following the vaccination and their families, as well as a control group of children with diabetes and their families. Longitudinal descriptive interviews will also be conducted with a selection of 20-25 children and their families. Techniques from media research will be used for Internet-based data collection and analysis of information relating to narcolepsy from social media. This project will use the situation of young persons with narcolepsy after the swine flu vaccination as a case to build a model that can be used in situations where trust in healthcare is essential. This model will be based on findings from the included studies on how trust is influenced by support, quality of life, burden of disease, impact on family, and use of social media. The model developed in this project will be beneficial in future situations where trust in healthcare is essential, such as new pandemic outbreaks but also for "everyday" adherence to health advice.

  12. 14 CFR 21.147 - Changes in quality control system.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Changes in quality control system. 21.147 Section 21.147 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... quality control system. After the issue of a production certificate, each change to the quality control...

  13. 14 CFR 145.211 - Quality control system.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Quality control system. 145.211 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.211 Quality control system. (a) A certificated repair station must establish and maintain a quality control system acceptable to...

  14. 7 CFR 58.523 - Laboratory and quality control tests.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Laboratory and quality control tests. 58.523 Section... Service 1 Operations and Operating Procedures § 58.523 Laboratory and quality control tests. (a) Quality control tests shall be made on samples as often as necessary to determine the shelf-life and stability of...

  15. 18 CFR 12.40 - Quality control programs.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Quality control... PROJECT WORKS Other Responsibilities of Applicant or Licensee § 12.40 Quality control programs. (a... meeting any requirements or standards set by the Regional Engineer. If a quality control program is...

  16. 21 CFR 640.56 - Quality control test for potency.

    Science.gov (United States)

    2010-04-01

    ... quality control test for potency may be performed by a clinical laboratory which meets the standards of... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Quality control test for potency. 640.56 Section...) BIOLOGICS ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Cryoprecipitate § 640.56 Quality control...

  17. Changes in Pore Water Quality After Peatland Restoration: Assessment of a Large-Scale, Replicated Before-After-Control-Impact Study in Finland

    Science.gov (United States)

    Menberu, Meseret Walle; Marttila, Hannu; Tahvanainen, Teemu; Kotiaho, Janne S.; Hokkanen, Reijo; Kløve, Bjørn; Ronkanen, Anna-Kaisa

    2017-10-01

    Drainage is known to affect peatland natural hydrology and water quality, but peatland restoration is considered to ameliorate peatland degradation. Using a replicated BACIPS (Before-After-Control-Impact Paired Series) design, we investigated 24 peatlands, all drained for forestry and subsequently restored, and 19 pristine control boreal peatlands with high temporal and spatial resolution data on hydroclimate and pore water quality. In drained conditions, total nitrogen (Ntot), total phosphorus (Ptot), and dissolved organic carbon (DOC) in pore water were several-fold higher than observed at pristine control sites, highlighting the impacts of long-term drainage on pore water quality. In general, pore water DOC and Ntot decreased after restoration measures but still remained significantly higher than at pristine control sites, indicating long time lags in restoration effects. Different peatland classes and trophic levels (vegetation gradient) responded differently to restoration, primarily due to altered hydrology and varying acidity levels. Sites that were hydrologically overrestored (inundated) showed higher Ptot, Ntot, and DOC than well-restored or insufficiently restored sites, indicating the need to optimize natural-like hydrological regimes when restoring peatlands drained for forestry. Rich fens (median pH 6.2-6.6) showed lower pore water Ptot, Ntot, and DOC than intermediate and poor peats (pH 4.0-4.6) both before and after restoration. Nutrients and DOC in pore water increased in the first year postrestoration but decreased thereafter. The most important variables related to pore water quality were trophic level, peatland class, water table level, and soil and air temperature.

  18. Sleep quality, morningness-eveningness preference, mood profile, and levels of serum melatonin in migraine patients: a case-control study.

    Science.gov (United States)

    Kozak, Hasan Hüseyin; Boysan, Murat; Uca, Ali Ulvi; Aydın, Adem; Kılınç, İbrahim; Genç, Emine; Altaş, Mustafa; Güngör, Dilara Cari; Turgut, Keziban; Özer, Nejla

    2017-03-01

    The melatonin as the pineal gland's secretory product is implicated in the pathophysiology of migraine. Melatonin has critical functions in human physiology, and research underscores the importance of melatonin in circadian rhythm, sleep, and mood regulation. Clinical observations have indicated that migraine attacks have a seasonal, menstrual, and circadian timing, suggesting that chronobiological mechanisms and their alterations may causally involve in the etiology of the disease. However, the topic has received relatively little attention in the migraine literature. Associations between melatonin, circadian preference, sleep, and mood states were investigated in the current study. Fifty-five patients (47 females and 8 males) were compared to 57 gender and age-matched control subjects (40 females and 17 males). A socio-demographical questionnaire, the Beck Depression Inventory, Beck Anxiety Inventory (BAI), Pittsburgh Sleep Quality Index (PSQI), Profile of Mood States (POMS), and Morningness-Eveningness Questionnaire were administered to volunteers. Blood samples were taken from all participants at about 1:00 AM in an unlit room not to hamper melatonin secretion, and blood melatonin levels were measured using quantitative ELISA test. In comparison with controls, melatonin levels were significantly lower among migraine patients. Migraineurs reported significantly greater scores on the BAI, confusion-bewilderment subscale of the POMS, and total and sleep latency subscale of the PSQI. Migraine patients who had nausea during the migraine attacks and who reported bouts relevant to certain food consumption, such as cheese or chocolate, had significantly lower levels of melatonin. Contrarily, groups did not reveal statistically substantial difference in circadian preferences.

  19. Model quality and safety studies

    DEFF Research Database (Denmark)

    Petersen, K.E.

    1997-01-01

    The paper describes the EC initiative on model quality assessment and emphasizes some of the problems encountered in the selection of data from field tests used in the evaluation process. Further, it discusses the impact of model uncertainties in safety studies of industrial plants. The model...... that most of these have never been through a procedure of evaluation, but nonetheless are used to assist in making decisions that may directly affect the safety of the public and the environment. As a major funder of European research on major industrial hazards, DGXII is conscious of the importance......-tain model is appropriate for use in solving a given problem. Further, the findings from the REDIPHEM project related to dense gas dispersion will be highlighted. Finally, the paper will discuss the need for model quality assessment in safety studies....

  20. Exercise training restores cardiac protein quality control in heart failure.

    Directory of Open Access Journals (Sweden)

    Juliane C Campos

    Full Text Available Exercise training is a well-known coadjuvant in heart failure treatment; however, the molecular mechanisms underlying its beneficial effects remain elusive. Despite the primary cause, heart failure is often preceded by two distinct phenomena: mitochondria dysfunction and cytosolic protein quality control disruption. The objective of the study was to determine the contribution of exercise training in regulating cardiac mitochondria metabolism and cytosolic protein quality control in a post-myocardial infarction-induced heart failure (MI-HF animal model. Our data demonstrated that isolated cardiac mitochondria from MI-HF rats displayed decreased oxygen consumption, reduced maximum calcium uptake and elevated H₂O₂ release. These changes were accompanied by exacerbated cardiac oxidative stress and proteasomal insufficiency. Declined proteasomal activity contributes to cardiac protein quality control disruption in our MI-HF model. Using cultured neonatal cardiomyocytes, we showed that either antimycin A or H₂O₂ resulted in inactivation of proteasomal peptidase activity, accumulation of oxidized proteins and cell death, recapitulating our in vivo model. Of interest, eight weeks of exercise training improved cardiac function, peak oxygen uptake and exercise tolerance in MI-HF rats. Moreover, exercise training restored mitochondrial oxygen consumption, increased Ca²⁺-induced permeability transition and reduced H₂O₂ release in MI-HF rats. These changes were followed by reduced oxidative stress and better cardiac protein quality control. Taken together, our findings uncover the potential contribution of mitochondrial dysfunction and cytosolic protein quality control disruption to heart failure and highlight the positive effects of exercise training in re-establishing cardiac mitochondrial physiology and protein quality control, reinforcing the importance of this intervention as a non-pharmacological tool for heart failure therapy.

  1. Dosimetry and quality control in radiodiagnosis

    International Nuclear Information System (INIS)

    Le Gouic, M.

    1983-07-01

    This work deals with physics of radiodiagnosis. In a first part a study of the characteristics of different kinds of radiological equipments and a quality assurance of some of them (standard radiography, coronarography and computed tomography) have been performed. The second part deals with patient irradiation. After a bibliographic study of radiodiagnosis dosimetry, two kinds of dosimetric measures have been made: ''in vitro'' measures, using a phantom, that had allowed to calibrate the equipment and to improve the individual irradiation card, and ''in vivo'' measures. For the first types of measures ionization chambers, have been used for the second thermoluminescent dosimeters [fr

  2. Impact on quality of life of IMRT versus 3-D conformal radiation therapy in head and neck cancer patients: A case control study

    Directory of Open Access Journals (Sweden)

    Edvard Abel, MD

    2017-07-01

    Conclusions: This study further supports the hypothesis that the introduction of IMRT has improved the long-term quality of life of HN cancer patients who have been treated with radiation therapy, but might cause more acute side effects. Longer follow-up is needed to study late complications.

  3. Quality control of ATLAS muon chambers

    CERN Document Server

    Fabich, Adrian

    ATLAS is a general-purpose experiment for the future Large Hadron Collider (LHC) at CERN. Its Muon Spectrometer will require ∼ 5500m2 of precision tracking chambers to measure the muon tracks along a spectrometer arm of 5m to 15m length, embedded in a magnetic field of ∼ 0.5T. The precision tracking devices in the Muon System will be high pressure drift tubes (MDTs). Approximately 370,000 MDTs will be assembled into ∼ 1200 drift chambers. The performance of the MDT chambers is very much dependent on the mechanical quality of the chambers. The uniformity and stability of the performance can only be assured providing very high quality control during production. Gas tightness, high-voltage behaviour and dark currents are global parameters which are common to gas detectors. For all chambers, they will be tested immediately after the chamber assembly at every production site. Functional tests, for example radioactive source scans and cosmic-ray runs, will be performed in order to establish detailed performan...

  4. Acceptance, commissioning and quality control in radiosurgery

    International Nuclear Information System (INIS)

    Toreti, Dalila Luzia

    2009-01-01

    Stereotactic Radiosurgery is a treatment technique that uses narrow beams of radiation focused with great accuracy in a small lesion. The introduction of micro multi leaf collimators (mMLC) allows this technique to reach a higher degree of dose conformation of the target lesion allowing a smaller irradiation of critical structures and normal tissues. This paper presents the results of the acceptance tests and commissioning of a Varian 6EX linear accelerator dedicated to radiosurgery associated with the BrainLab micro multi leaf collimator installed in the Hospital das Clinicas da Faculdade de Medicina da USP (HC-FMUSP) and establish feasible quality assurance program for the services that employ this special technique. The results of the acceptance tests were satisfactory and are willing with the specifications provided by the manufacturer and the commissioning tests were within the international recommendations. The tests and measures that are part of quality control process should be specific to each treatment unit, and the need, frequency and levels of tolerance

  5. Quality control in nuclear fuel fabrication

    International Nuclear Information System (INIS)

    Abdelhalim, A.S.; Elsayed, A.A.; Shaaban, H.I.

    1988-01-01

    The department of metallurgy, NRC Inchass is embarking on a programme of on a laboratory scale, fuel pins containing uranium dioxide pellets are going to be produced. The department is making use of the expertise and equipment at present available and is going to utilize the new fuel pin fabrication unit which would be shortly in operation. The fabrication and testing of uranium dioxide pellets then gradually adapt them and develop, a national know how in this field. This would also involve building up of indigenous experience through proper training of qualified personnel. That are applied to ensure quality of U o 2 pellets, the techniques implemented, the equipment used and the specifications of the equipment presently available. The following parameters are subject to quality control tests: density. O/U ration, hydrogen content, microstructure, each property will be discussed, measurements related to U o 2 powders, including flow ability, bulk density, O/U ratio, bet surface area and water content will be critically discussed. Relevant tests to ensure Q C of pellets are reviewed. These include surface integrity, density, dimensions, microstructure.4 fig., 1 tab

  6. Tools for quality control of fingerprint databases

    Science.gov (United States)

    Swann, B. Scott; Libert, John M.; Lepley, Margaret A.

    2010-04-01

    Integrity of fingerprint data is essential to biometric and forensic applications. Accordingly, the FBI's Criminal Justice Information Services (CJIS) Division has sponsored development of software tools to facilitate quality control functions relative to maintaining its fingerprint data assets inherent to the Integrated Automated Fingerprint Identification System (IAFIS) and Next Generation Identification (NGI). This paper provides an introduction of two such tools. The first FBI-sponsored tool was developed by the National Institute of Standards and Technology (NIST) and examines and detects the spectral signature of the ridge-flow structure characteristic of friction ridge skin. The Spectral Image Validation/Verification (SIVV) utility differentiates fingerprints from non-fingerprints, including blank frames or segmentation failures erroneously included in data; provides a "first look" at image quality; and can identify anomalies in sample rates of scanned images. The SIVV utility might detect errors in individual 10-print fingerprints inaccurately segmented from the flat, multi-finger image acquired by one of the automated collection systems increasing in availability and usage. In such cases, the lost fingerprint can be recovered by re-segmentation from the now compressed multi-finger image record. The second FBI-sponsored tool, CropCoeff was developed by MITRE and thoroughly tested via NIST. CropCoeff enables cropping of the replacement single print directly from the compressed data file, thus avoiding decompression and recompression of images that might degrade fingerprint features necessary for matching.

  7. Quality control tests for conventional mammography

    International Nuclear Information System (INIS)

    Dawod, Alnazer Ahmed Ibrahim

    2014-12-01

    Mammography is this the test that allows the radiologist to look at images of the inside of the breasts. Mammograms help detect breast cancer early successful treatment of breast cancer depends on that early diagnosis. Breast cancer is a very common condition. About one in every nine women develops breast cancer by the age of eighty. In addition to the clinical examination and self-examination, mammography plays important role in the detection of breast cancer before they become clinically visible tumors. The mammography is the most common test for early detection of breast cancer. Quality control techniques that done ensured importance of this programme to produce images with good diagnostic values and help radiologist to diagnose breast discase easily and avoid exposing patient to radiation hazards.(Author)

  8. Associated factors with functional disability and health-related quality of life in Chinese patients with gout: a case-control study.

    Science.gov (United States)

    Fu, Ting; Cao, Haixia; Yin, Rulan; Zhang, Lijuan; Zhang, Qiuxiang; Li, Liren; Gu, Zhifeng

    2017-11-03

    Gout is a painful, inflammatory disease that may cause decreased function and health-related quality of life (HRQoL). Limited study did not take the influence of gout characteristics and anxiety on HRQoL into consideration and there are no studies associated with functional disability in individuals with gout from China. This study aims to investigate the related factors of functional disability and HRQoL in gout patients recruited from China. A total of 226 consecutive gout patients and 232 age- and gender-matched healthy individuals were involved in the study. A series of questionnaires (the Short Form 36 health survey, the Patient Health Questionnaire, the Generalized Anxiety Disorder questionnaire, the 10 cm Visual Analog Scale, and the Health Assessment Questionnaire-Disability Index) were applied. Blood samples were taken to examine the level of serum uric acid. Independent samples t-tests, Chi square tests, U test, Spearman rank correlation, logistic regression modeling, and linear regression were used to analyze the data. After adjusted demographic variables, individuals with gout have poorer HRQoL compared to healthy controls. Univariate tests presented that patients with functional disability had longer disease duration, more frequent flares/last year, more severe total pain, more number of tophi, higher degree of depression and anxiety, with a trend toward diabetes, the treatment of colchicine and corticosteroids use, compared to patients without functional disability. Meanwhile, place of residence, hypertension, DM, disease duration, cardiovascular disease, number of flares/last year, total pain, more number of tophi, presence of tender joints, depression, anxiety, currently using colchicine and corticosteroids were correlated significantly with HRQoL. Additionally, multiple regression analysis identified severe pain, depression, and colchicine use as predictors of functional disability. Cardiovascular disease, total pain, number of flares/last year

  9. The association between the Index of Nutritional Quality (INQ) and breast cancer and the evaluation of nutrient intake of breast cancer patients: A case-control study.

    Science.gov (United States)

    Vahid, Farhad; Hatami, Mahshid; Sadeghi, Mahya; Ameri, Fatemeh; Faghfoori, Zeinab; Davoodi, Sayed Hossein

    2018-01-01

    Breast cancer (BrCa) is the most frequently diagnosed cancer among females and second cancer after lung cancer in many societies. In Iran, the risk for BrCa is 1 in 35 and each year, 8000 new patients have been diagnosed with BrCa. Studies have shown that dietary components are implicated in the etiology of BrCa. The Index of Nutritional Quality (INQ) is a method of quantitative and qualitative analysis of single foods, meals, and diets. The aim of this study was to determine the usefulness of INQs in predicting BrCa risk. Our case-control study was conducted from March 2015 to February 2016. The study included 145 cases and 148 controls who attended the Shahid Beheshti University of Medical Sciences Cancer Research Center. INQ scores were computed based on dietary intake using a validated 168-item food frequency questionnaire. Logistic regression models were used to estimate multivariable odds ratios adjusted body mass index, education, employment, marital status, menarche age, childbirth number, smoking, menopause status, and physical activity. Vitamins A, C, B 1 , B 2 , and B 12 and selenium INQs as a continuous variable in relation to risk for BrCa showed a significant association after multivariate adjustment (odds ratio [OR] vitA , 0.41 [0.27-0.64]; OR vitC , 0.30 [0.20-0.47]; OR vitB1 , 0.08 [0.04-0.17]; OR vitB2 , 0.19 [0.11-0.34]; OR vitB12 , 0.44 [0.31-0.61]; and OR selenium , 0.42 [0.26-0.67]). Women who consumed a healthier diet including vitamin A, β-carotene, vitamin C, and folate and low-fat milk were at decreased risk for developing BrCa compared with those whose diet included more high fat and lamb meat. Copyright © 2017 Elsevier Inc. All rights reserved.

  10. Analytical quality control [An IAEA service

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1973-07-01

    In analytical chemistry the determination of small or trace amounts of elements or compounds in different types of materials is increasingly important. The results of these findings have a great influence on different fields of science, and on human life. Their reliability, precision and accuracy must, therefore, be checked by analytical quality control measures. The International Atomic Energy Agency (IAEA) set up an Analytical Quality Control Service (AQCS) in 1962 to assist laboratories in Member States in the assessment of their reliability in radionuclide analysis, and in other branches of applied analysis in which radionuclides may be used as analytical implements. For practical reasons, most analytical laboratories are not in a position to check accuracy internally, as frequently resources are available for only one method; standardized sample material, particularly in the case of trace analysis, is not available and can be prepared by the institutes themselves only in exceptional cases; intercomparisons are organized rather seldom and many important types of analysis are so far not covered. AQCS assistance is provided by the shipment to laboratories of standard reference materials containing known quantities of different trace elements or radionuclides, as well as by the organization of analytical intercomparisons in which the participating laboratories are provided with aliquots of homogenized material of unknown composition for analysis. In the latter case the laboratories report their data to the Agency's laboratory, which calculates averages and distributions of results and advises each laboratory of its performance relative to all the others. Throughout the years several dozens of intercomparisons have been organized and many thousands of samples provided. The service offered, as a consequence, has grown enormously. The programme for 1973 and 1974, which is currently being distributed to Member States, will contain 31 different types of materials.

  11. The growing need for analytical quality control

    International Nuclear Information System (INIS)

    Suschny, O.; Richman, D.M.

    1974-01-01

    Technological development in a country is directly dependent upon its analytical chemistry or measurement capability, because it is impossible to achieve any level of technological sophistication without the ability to measure. Measurement capability is needed to determine both technological competence and technological consequence. But measurement itself is insufficient. There must be a standard or a reference for comparison. In the complicated world of chemistry the need for reference materials grows with successful technological development. The International Atomic Energy Agency has been distributing calibrated radioisotope solutions, standard reference materials and intercomparison materials since the early 1960's. The purpose of this activity has been to help laboratories in its Member States to assess and, if necessary, to improve the reliability of their analytical work. The value and continued need of this service has been demonstrated by the results of many intercomparisons which proved that without continuing analytical quality control activities, adequate reliability of analytical data could not be taken for granted. Analytical chemistry, lacking the glamour of other aspects of the physical sciences, has not attracted the attention it deserves, but in terms of practical importance, it warrants high priority in any developing technological scheme, because without it there is little chance to evaluate technological success or failure or opportunity to identify the reasons for success or failure. The scope and the size of the future programme of the IAEA in this field has been delineated by recommendations made by several Panels of Experts; all have agreed on the importance of this programme and made detailed recommendations in their areas of expertise. The Agency's resources are limited and it cannot on its own undertake the preparation and distribution of all the materials needed. It can, however, offer a focal point to bring together different

  12. Educational attainment, perceived control and the quality of women's diets.

    Science.gov (United States)

    Barker, Mary; Lawrence, Wendy; Crozier, Sarah; Robinson, Siân; Baird, Janis; Margetts, Barrie; Cooper, Cyrus

    2009-06-01

    Data from the Southampton Women's Survey have established that women of lower educational attainment have poorer quality diets than those of higher educational attainment. This relationship is strong and graded such that for every increase in level of educational qualification, there is an increase in the likelihood that a woman will have a better quality diet. It is not wholly explained by socio-economic status. Qualitative research carried out in Southampton suggests that women of lower educational attainment may have a poorer diet because they feel they lack control over the food choices they make for themselves and their families. We set out to investigate the relationship between educational attainment, perceived control and quality of diet in a sample of women from Southampton. Cross-sectional study using structured interviews in which women's diet, educational attainment and perceived control were assessed. 19 Children's Centres and baby clinics in Southampton, UK. 372 women, median age 28 years. Quality of diet assessed by prudent diet score produced from principal components analysis of 20-item food frequency questionnaire, and perceived control assessed by a validated questionnaire. Women of lower educational attainment tended to have lower prudent diet scores and lower perceived control scores than women of higher educational attainment. Having a lower prudent diet score was associated with consuming fewer vegetables and vegetable dishes, less wholemeal bread and vegetarian food, and more chips and roast potatoes, meat pies, Yorkshire puddings and pancakes, crisps and snacks, white bread and added sugar. In a regression model both lower educational attainment and lower perceived control were associated with lower prudent diet scores, independent of the effects of confounding factors. However there was an interaction effect such that lower perceived control was only related to prudent diet score in the group of women of lower educational attainment. Women

  13. Factors associated with quality of life of outpatients with breast cancer and gynecologic cancers and their family caregivers: a controlled study

    Directory of Open Access Journals (Sweden)

    Hamad Hussein MA

    2007-06-01

    Full Text Available Abstract Background Quality of life (QOL issues are of interest in cancer because effective methods of treatment and detection have led to an increase in the number of long-term survivors. The objectives of the study were: to assess the subjective QOL of stable Sudanese women cancer outpatients and their family caregivers, using the WHO 26-item QOL Instrument; compare with matched general population groups, as well as diabetic and psychiatric patient groups; examine patient-caregiver concordance in ratings; and assess the variables associated with their QOL, with a view to identifying factors that can enhance quality of care. Methods Responses of oncology outpatients with breast cancer (117, cervical cancer (46 and ovarian cancer (18 (aged 44.6, SD 11.5 were compared with those of their family caregivers and matched general population groups. Data were analyzed by univariate and multivariate statistics. Results The cancer groups had similar QOL domain scores, which were significantly lower than those of their caregivers, but higher than the control group as well as those of psychiatric and diabetic patients studied previously. Patients who were married, with higher education, better employment, and with longer duration of illness had higher QOL. Patients on radiotherapy and their caregivers had higher QOL scores. Correlations between patient's ratings and caregiver impression of patient's QOL were high. Caregiver impression was a significant predictor of patient's and caregiver's QOL. Other predictors for the patient were: currently feeling sick and duration of illness; for the caregiver: feeling sick, relationship to patient, and age. Conclusion Cancer patients in stable condition and with psychosocial support can hope to enjoy good QOL with treatment. The findings constitute an evidence base for the country's cancer care program, to boost national health education about prognosis in cancer. Families living with women cancer patients are

  14. Terms and definitions of quality assurance/quality control

    International Nuclear Information System (INIS)

    Kaden, W.

    1980-01-01

    Terms of quality assurance are defined and interpreted. Reference is made to the IAEA Code of Practice and to other important Codes and Standards like ANSI, ASME and KTA. The relevance of these terms to everyday's work and problems of a quality assurance engineer is explained. (orig.)

  15. Quality control of some CT scanners in Khartoum state

    International Nuclear Information System (INIS)

    Yousif, Ali Mohammed Ali

    2013-06-01

    This study conduced with the aim to evaluate the performance of three CT scanner in Khartoum-Sudan through extensive quality control measurements. Image quality was assessed using a CATPHAN 412 CT image quality phantom. Image quality parameters evaluated were: CT image noise, uniformity, CT number linearity, Low Contrast Resolution, High Contrast Resolution, measurements were performed in accordance with guidelines set out by the Institute of physical science and engineering in medicine (IPEM 91). Image quality parameters tested were within the apoplectic limit specified in the relevant CT guidelines. Measured slice thickness ranged between 9.66-10.5 mm for large slice and 5.25-5.88 for medium slice. The correlation coefficient (R) between the measured and the reference CT number was better than 0.99 for all CT scanners. High resolution for large slice was 7 L P/ cm and 8 L P/ cm for small slice. Low contrast resolution with 1.0% nominal level ranged between 2-3 mm diameter of disc for large slice and 4-7 mm diameter disc for small slice. The measured noise ranged between 1.4-3.4 HU for large slice and 2.92-4.08 HU for small slice. Uniformity ranged between 3.08 to 2.075 HU for large slice and 3.22 to 1.4 HU for small slice thickness. The results indicate that routine maintenance, service and calibration, as well as the frequent quality control of CT scanners play a key rote in achieving the best performance of the system. Since computed tomography (CT) contributes the most to the collective dose compared to other radiological examinations, it is a necessity for quality control and quality assurance programs to be established in each radiology department.(Author)

  16. [Compatibility of different quality control systems].

    Science.gov (United States)

    Invernizzi, Enrico

    2002-01-01

    Management of the good laboratory practice (GLP) quality system presupposes its linking to a basic recognized and approved quality system, from which it can draw on management procedures common to all quality systems, such as the ISO 9000 set of norms. A quality system organized in this way can also be integrated with other dedicated quality systems, or parts of them, to obtain principles or management procedures for specific topics. The aim of this organization is to set up a reliable, recognized quality system compatible with the principles of GLP and other quality management systems, which provides users with a simplified set of easily accessible management tools and answers. The organization of this quality system is set out in the quality assurance programme, which is actually the document in which the test facility incorporates the GLP principles into its own quality organization.

  17. Tc99m MDP kits, production and quality control

    International Nuclear Information System (INIS)

    Othman, I.; Yassine, T.; Lababidi, Z.; Kouli, M.

    1992-11-01

    MDP kits for labelling with Tc 99m were locally produced in different conditions, and the conditions for preparation were optimized. The quality control studies showed that the prepared kits were very good quality and comparable with that imported. Radiochemical purities ranged between 95-98% while reduced technetium ranged between 2-3% and free pertechnetate did not exceed 1%. Bioscan and biodistribution studies also showed high localization of Tc 99m in the skeleton of rats and rabbits. (author). 8 refs., 14 tabs

  18. The IVAIRE project--a randomized controlled study of the impact of ventilation on indoor air quality and the respiratory symptoms of asthmatic children in single family homes.

    Science.gov (United States)

    Lajoie, P; Aubin, D; Gingras, V; Daigneault, P; Ducharme, F; Gauvin, D; Fugler, D; Leclerc, J-M; Won, D; Courteau, M; Gingras, S; Héroux, M-È; Yang, W; Schleibinger, H

    2015-12-01

    A randomized controlled trial was carried out to measure the impact of an intervention on ventilation, indoor air contaminants, and asthma symptoms of children. Eighty-three asthmatic children living in low-ventilated homes were followed over 2 years. Several environmental parameters were measured during the summer, fall, and winter. The children were randomized after Year 1 (43 Intervention; 40 Control). The intervention included the installation of either a Heat Recovery Ventilator (HRV) or Energy Recovery Ventilator (ERV). During the fall and winter seasons, there was a significant increase in the mean ventilation rate in the homes of the intervention group. A statistically significant reduction in mean formaldehyde, airborne mold spores, toluene, styrene, limonene, and α-pinene concentrations was observed in the intervention group. There was no significant group difference in change in the number of days with symptoms per 14 days. However, there was a significant decrease in the proportion of children who experienced any wheezing (≥1 episode) and those with ≥4 episodes in the 12-month period in the intervention group. This study indicates that improved ventilation reduces air contaminants and may prevent wheezing. Due to lack of power, a bigger study is needed. Positive findings from this study include the fact that, upon recruitment, most of the single family homes with asthmatic children were already equipped with a mechanical ventilation system and had relatively good indoor air quality. However, the 8-h indoor guideline for formaldehyde (50 μg/m3) was frequently exceeded and the ventilation rates were low in most of the homes, even those with a ventilation system. Both ERVs and HRVs were equally effective at increasing air exchange rates above 0.30 ACH and at preventing formaldehyde concentrations from exceeding the 50 μg/m3 guideline during the fall and winter seasons. Furthermore, the ERVs were effective at preventing excessively low relative

  19. Control de la calidad y estudio de estabilidad del paracetamol gotas orales 100 mg/ml Quality control and stability study of 100 mg/ml paracetamol oral drops

    Directory of Open Access Journals (Sweden)

    Caridad M García Peña

    2013-03-01

    the non-steroidal anti-inflammatory drug group. Paracetamol oral drops are indicated for use in infant population aged up to 5 years to relieve fever, headache, toothache and symptomatic relief of common cold. Objective: to validate two analytical methods for the quality control and the stability study and to study the stability of 100 mg/ml Paracetamol oral drops made in Cuba. Methods: for quantification of the active principle in the final product in order to study stability, a chromatographic column equipment called Lichrosorb RP-18 was used for separation (5µm (250 x 4 mm, with ultraviolet ray detection at 243 nm and a mobile phase made up of distilled water: methanol (3:1 and the quantification of this principle against a reference sample by using the external standard method. For the quality control, the spectrophotometry used the spectrophotometer SPECTRONIC GENESYS 2, the ideal wavelength was 245 nm since it matches the maximum absorption rate and there is no interference with the excipients. As to the stability study of the drops, the on- shelf life method (temperature below 30 C was used, and for the accelerated stability analysis (40 ± 2ºC through high performance liquid chromatography. Results: the results of the evaluated parameters in the validation of the methods for the quality control and the stability study were within the set limits. The results of the stability study, both accelerated and on- shelf life and reservoir use, showed that the final product met the quality specifications during the study. Conclusions: the analytical methods based on UV spectrophotometry and high performance liquid chromatography are valid for the quality control and the stability study of 100 mg/ml Paracetamol oral drops, since they are linear, precise, accurate and specific. The physical, chemical and microbiological stability of the product was proved for 12 months at a temperature below 30ºC, packed in 15 ml amber glass reservoirs, 18mm opening and hydrolytic

  20. Quality control: comparison of images quality with screen film system and digital mammography CR

    International Nuclear Information System (INIS)

    Alvarenga, Frederico L.; Nogueira, Maria do Socorro

    2008-01-01

    The mammography screen film system should be used as part of processing chemicals, revelation process, equipment and this system has have a progressive replacing by the digital technology Full Field Digital Mammography FFDM, Computed Radiography (CR) Mammography and hardcopy. This new acquisition process of medical images has improved radiology section; however it is necessary efficient means for evaluating of the quality parameters. It should be considered taking into account the adaptation of the existent equipment and that procedures adopted for the exam, as well the adaptation of the new mammography films, the radiologist view box constitutes a part of the quality control program. This program aims at obtaining radiography with good quality that allows obtaining more information for the diagnosis and decreases the patient dose. For evaluation the quality image, this article is focused on presenting the differences regarding the acquired images through simulator mammography radiographic PMMA (Poly methyl methacrylate) in CR Mammography system and screen film system. The tests were accomplished at the same equipment of Mammography with the Automatic Exposure Control using a tension of 28 kV for both systems. The quality tests evaluated the spatial resolution, the own structures of the phantom, artifacts, optical density and contrast with conventional and laser films by mammography system. The installation for the accomplishment of the test has a quality control program. The evaluation was based on the pattern developed by the competent organ of the State of Minas Gerais. In this study, it was verified that the suitable Phantom Mama used by the Brazilian School of Radiology for conventional mammography did not obtain satisfactory result for Spatial Resolution in the digital mammography system CR. The final aim of this work is to obtain parameters to characterize the reference phantom quality image in an objective way. These parameters will be used to compare

  1. standards used for quality control of nuclear fuels

    International Nuclear Information System (INIS)

    Guereli, L; Can, S.

    1997-01-01

    Nuclear fuels and fuel materials are subject to stringent restrictions as to their quality. The standards and regulations that apply vary according to reactor type and country and the standards are stated in the quality assurance documents. The concept of quality assurance has altered the conventional quality control tests and procedures, defining which control tests are to be applied and how. Although most of the tests and measurements allow the determination of tolerances to be decided according to the agreement between the buyer and the seller, exacting procedures apply to which instruments and equipment are used for these tests and measurements, how these instruments are standardized.Detailed explanations of test methods and their documentation is a requirement in all standards. The purpose of this work is to study which standards, tests and measurements apply to the nuclear fuel production. Only the standards that apply to various stages of the nuclear fuel production (powder preparation, pellet production, fuel element and fuel assembly fabrication) are reviewed. Process and documentation control, design and licensing requirements and the frequency of inspections are quality assurance subjects. Some ASTM standards are given as examples

  2. Chapter 5: Quality assurance/quality control in stormwater sampling

    Science.gov (United States)

    Sampling the quality of stormwater presents unique challenges because stormwater flow is relatively short-lived with drastic variability. Furthermore, storm events often occur with little advance warning, outside conventional work hours, and under adverse weather conditions. Therefore, most stormwat...

  3. Quality control of radioimmunoassay kits of pituitary hormones

    International Nuclear Information System (INIS)

    Caso Pena, R.; Arranz Calzado, C.

    1997-01-01

    The present work describe the quality control procedures carried out on three RIA-Kits by the Isotopes Centre of Cuba, The subject matter of study were ;: were: LH-RIA-Kit, FSH-RIA-Kit and Prolactin- RIA -Kit. The controls have included the characterization of the 125 I labelled hormones the specific antibodies, the 2 nd antibodies, the standards curves and the control serum. For the validation of these Kits were used reference standards from the WHO (World Health Organizations) and Kits from CIS company (France) based on the IRMA assays technologies . The results obtained allow us encourage the reliability of RIA-Kits

  4. Team care to cure adolescents with braces (avoiding low quality of life, pain and bad compliance): a case-control retrospective study. 2011 SOSORT Award winner.

    Science.gov (United States)

    Tavernaro, Marta; Pellegrini, Anna; Tessadri, Fabrizio; Zaina, Fabio; Zonta, Andrea; Negrini, Stefano

    2012-09-20

    Bracing could be efficacious, given good compliance and quality of braces. Recently the SOSORT Brace TREATMENT Management Guidelines (SBTMG) have highlighted the perceived importance of the professional teams surrounding braced patients. To verify the impact of a complete rehabilitation team in the adolescent patient with bracing. Design. Initial cross-sectional study, followed by a retrospective case-control study. Thirty-eight patients (15.8 ± 1.6 years; 26 females; 10 hyperkyphosis, 28 scoliosis of 29.2 ± 7.9° Cobb) extracted from a single orthotist database (between January 1, 2008 and September 1, 2009) and treated by the same physician; brace wearing at least 15 hours/day for a minimum of 6 months; age 10 or more. Braces: Sforzesco, Sibilla, Lapadula or Maguelone. Exercises: SEAS. Two questionnaires filled in blindly by patients: SRS-22 and one especially developed and validated with 25 questions on adherence to treatment. Groups (main risk factor): TEAM (private institute: satisfied 44/44 SOSORT criteria; grade of teamwork, "excellent") included 13 patients and NOT 25 (National Health Service Rehabilitation Department: 35/44 SOSORT criteria respected; grade, "insufficient"). TEAM was more compliant to bracing than NOT (97 ± 6% vs. 80 ± 24%) and performed nearly double the exercises (38 ± 12 vs. 20 ± 13 minutes/session). The self-reduction of bracing was significant in NOT (from 16.8 ± 3.7 to 14.8 ± 4.9 hours/day, , Pversus 7% of TEAM (P < 0.05). The populations did not differ at the baseline studied outcomes. The absence of a good team surrounding the patient increases by five times the risk of reduced compliance to bracing (odds ratio OR 5.5 - 95% confidence interval 95CI 3.6-7.4), along with more than 15 times that of QoL problems (OR 15.7 - 95CI 13.6-17.9) and pain (OR 16.8 - 95CI 14.5-19.1). Provided the limits of this first study on the topic, the SBTMG seems to be important for brace treatment

  5. 21 CFR 111.117 - What quality control operations are required for equipment, instruments, and controls?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false What quality control operations are required for equipment, instruments, and controls? 111.117 Section 111.117 Food and Drugs FOOD AND DRUG ADMINISTRATION... and Process Control System: Requirements for Quality Control § 111.117 What quality control operations...

  6. River sediment (S-37)--a new analytical quality control material ensuring comparability of chlorinated hydrocarbon analysis during an international environmental study in China.

    Science.gov (United States)

    Gawlik, B M; Martens, D; Henkelmann, B; Schramm, K W; Kettrup, A; Muntau, H

    2000-06-01

    A sediment reference material (S-37) was prepared as analytical quality control material to be used within an international project on polychlorinated hydrocarbon analysis in two Chinese rivers. The raw material was sampled during a cruise on Yangtse River and transported afterwards to the JRC Ispra for further processing. The material was treated according to the general principles applicable for candidate reference material production. After a thorough homogeneity study of the bulk the material was bottled. A total of 1,080 bottles each containing 50 g of dry sediment powder was obtained. Final homogeneity and stability testing proved the material to be fit for the purpose. Isotope dilution GC/MS was used to establish target values for pentachlorobenzene (1.17 +/- 0.08 ng/g), hexachlorobenzene (3.60 +/- 0.17 ng/g), octachlorostyrene (0.19 +/- 0.01 ng/g), pentachloroanisole (0.52 +/- 0.02 ng/g), alpha-HCH (0.70 +/- 0.05 ng/g), beta-HCH (1.38 +/- 0.18 ng/g), gamma-HCH (0.83 +/- 038 ng/g), 2,4'-DDT (0.36 +/- 0.04 ng/g), 2,4'-DDE (0.29 +/- 0.02 ng/g), 2,4'-DDD (0.49 +/- 0.02), 4,4'-DDT (3.42 +/- 0.47 ng/g), 4,4'-DDD (1.29 +/- 0.17 ng/g), PCB 28 (0.11 +/- 0.01 ng/g), PCB 52 (0.09 +/- 0.003 ng/g), PCB 101 (0.07 +/- 0.003 ng/g), PCB 138 (0.06 +/- 0.003 ng/g) and PCB 153 (0.06 +/- 0.003 ng/g). Furthermore, indicative values for major and minor constituents as well as for polychlorinated dibenzodioxines and -furanes were measured.

  7. An Austrian framework for PET quality control

    International Nuclear Information System (INIS)

    Nicoletti, R.; Dobrozemsky, G.; Minear, G.; Bergmann, H.

    2002-01-01

    Full text: The European patient protection directive (97/43 EURATOM) requires regular routine quality control (QC) of PET imaging devices. Since no standards were available covering this area and in order to comply with the directive a joint working party of the Austrian societies of nuclear medicine and of medical physics have developed a set of procedures suitable for both dedicated PET scanners and gamma cameras operating in coincidence mode (GCPET). The routine procedures proposed include both manufacturer recommended procedures and tests for specific parameters and calibration procedures. Wherever possible, procedures adapted or derived from NEMA standards publication NU 2-2001 were used to permit direct comparison with specified parameters of image quality. For dedicated PET scanners the most important procedures are the checking of detector sensitivities and the attenuation calibration scan. With full ring scanners the attenuation calibration scan is a blank scan, with partial ring devices a special attenuation calibration phantom has to be used. Test protocols are specific to manufacturer and scanner type. They are usually performed automatically overnight. In addition, some instruments require special calibrations, e.g. gain adjustments or coincidence timing calibration. GCPET procedures include the frequent assessment in coincidence mode of detector uniformity, energy resolution and system sensitivity. Common to both dedicated PET and GCPET are the regular quarterly assessment of tomographic spatial resolution and the calibration of the system for quantitative measurements. As a total performance test for both systems assessment of image quality following NU 2-2001 was included, to be carried out after major system changes or repairs. The suite of QC procedures was tested on several dedicated PET and GCPET systems including all major manufacturers' systems. Due to missing hardware or software not all tests could be performed on all systems. Some of the

  8. Genetic variation at loci controlling quality traits in spring wheat

    International Nuclear Information System (INIS)

    Ali, N.; Iqbal, M.; Asif, M.

    2013-01-01

    Selection for quality traits in bread wheat (Triticum aestivum L.) during early breeding generations requires quick analytical methods that need small grain samples. Marker assisted selection can be useful for the improvement of quality traits in wheat. The present study was conducted to screen 117 Pakistani adapted spring wheat varieties with DNA markers linked with genes controlling composition of low and high molecular weight glutenin subunits (LMW-GS and HMW-GS, respectively), starch viscosity, Polyphenol oxidase (PPO) activity and grain hardness. DNA fragments associated with the presence/absence of quality related genes were amplified using Polymerase chain reaction (PCR) and detected using agarose gel electrophoresis. Positive allele of beta-secalin, which indicates presence of 1B.1R translocation, was found in 77 (66%) varieties. The marker PPO05 was found in 30 (26%) varieties, indicating lower PPO activity. Grain hardness controlled by Pinb-D1b allele was present in 49 (42%) varieties. Allele Wx-B1b which confers superior noodle quality was found in 48 (41%) varieties. HMW-GS encoded by Glu-D1d allele that exerts a positive effect on dough strength was present in 115 (98%) varieties. LMW-GS alleles Glu-A3d and Glu-B3 were observed in 21 (18%) and 76 (65%) varieties, respectively. Results of the present study may help wheat breeders in selecting parents for improving desirable quality attributes of future wheat varieties. The varieties, identified having desirable quality genes, in this study can be used in the wheat breeding programs aiming to improve quality traits. Early generation marker assisted selection can help to efficiently utilize resources of a breeding program. (author)

  9. Effect of mindfulness and yoga on quality of life for elementary school students and teachers: results of a randomized controlled school-based study.

    Science.gov (United States)

    Bazzano, Alessandra N; Anderson, Christopher E; Hylton, Chelsea; Gustat, Jeanette

    2018-01-01

    To assess the impact of a yoga curriculum in an elementary school on student quality of life, and to assess teacher and staff perception of potential barriers to, and benefits of, introducing yoga and mindfulness into the classroom. A randomized controlled trial was utilized to assess the impact of a brief intervention on third-grade students who screened positive for symptoms of anxiety. Students were randomized to an intervention group of 20 students receiving small-group yoga/mindfulness activities for 8 weeks between October 2016 and February 2017, and a control group of 32 students receiving care as usual. The Brief Multidimensional Students' Life Satisfaction Scale-Peabody Treatment Progress Battery and the Pediatric Quality of Life Inventory (PedsQL) served as outcomes. Teachers were invited to participate in two professional development sessions about introducing yoga and mindfulness into the classroom, and completed a survey following each of the sessions. In generalized estimating equation models adjusted for time, the yoga-based intervention was associated with a 14.17 unit increase in student emotional PedsQL ( p -value 0.001) and a 7.43 unit increase in psychosocial PedsQL ( p -value 0.01). Results were not attenuated by adjustment. Teachers and staff reported using yoga more frequently in the classroom following the second of two professional development sessions ( p -value classroom were similar at two data collection time points, while perceived benefits remained high. The intervention was associated with a significant improvement in emotional and psychosocial quality of life in the intervention group when compared to the control group, suggesting that yoga/mindfulness interventions may improve symptoms of anxiety among students. Yoga/mindfulness activities may facilitate stress management among elementary school students and may be added as a complement to social and emotional learning activities.

  10. Team care to cure adolescents with braces (avoiding low quality of life, pain and bad compliance: a case–control retrospective study. 2011 SOSORT Award winner

    Directory of Open Access Journals (Sweden)

    Tavernaro Marta

    2012-09-01

    Full Text Available Abstract Background Bracing could be efficacious, given good compliance and quality of braces. Recently the SOSORT Brace Treatment Management Guidelines (SBTMG have highlighted the perceived importance of the professional teams surrounding braced patients. Purpose To verify the impact of a complete rehabilitation team in the adolescent patient with bracing. Materials and methods Design. Initial cross-sectional study, followed by a retrospective case–control study. Population: Thirty-eight patients (15.8 ± 1.6 years; 26 females; 10 hyperkyphosis, 28 scoliosis of 29.2 ± 7.9° Cobb extracted from a single orthotist database (between January 1, 2008 and September 1, 2009 and treated by the same physician; brace wearing at least 15 hours/day for a minimum of 6 months; age 10 or more. Treatment: Braces: Sforzesco, Sibilla, Lapadula or Maguelone. Exercises: SEAS. Methods: Two questionnaires filled in blindly by patients: SRS-22 and one especially developed and validated with 25 questions on adherence to treatment. Groups (main risk factor: TEAM (private institute: satisfied 44/44 SOSORT criteria; grade of teamwork, “excellent” included 13 patients and NOT 25 (National Health Service Rehabilitation Department: 35/44 SOSORT criteria respected; grade, “insufficient”. Results TEAM was more compliant to bracing than NOT (97 ± 6% vs. 80 ± 24% and performed nearly double the exercises (38 ± 12 vs. 20 ± 13 minutes/session. The self-reduction of bracing was significant in NOT (from 16.8 ± 3.7 to 14.8 ± 4.9 hours/day, , P Conclusions Provided the limits of this first study on the topic, the SBTMG seems to be important for brace treatment, influencing pain, QoL and compliance (and so, presumably, final results. Future studies on the topic are advisable.

  11. 7 CFR 58.733 - Quality control tests.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Quality control tests. 58.733 Section 58.733... Procedures § 58.733 Quality control tests. (a) Chemical analyses. The following chemical analyses shall be... pasteurization by means of the phosphatase test, as well as any other tests necessary to assure good quality...

  12. Performance and quality control of nuclear medicine instrumentation

    International Nuclear Information System (INIS)

    Paras, P.

    1981-01-01

    The status and the recent developments of nuclear medicine instrumentation performance, with an emphasis on gamma-camera performance, are discussed as the basis for quality control. New phantoms and techniques for the measurement of gamma-camera performance parameters are introduced and their usefulness for quality control is discussed. Tests and procedures for dose calibrator quality control are included. Also, the principles of quality control, tests, equipment and procedures for each type of instrument are reviewed, and minimum requirements for an effective quality assurance programme for nuclear medicine instrumentation are suggested. (author)

  13. Statistical method for quality control in presence of measurement errors

    International Nuclear Information System (INIS)

    Lauer-Peccoud, M.R.

    1998-01-01

    In a quality inspection of a set of items where the measurements of values of a quality characteristic of the item are contaminated by random errors, one can take wrong decisions which are damageable to the quality. So of is important to control the risks in such a way that a final quality level is insured. We consider that an item is defective or not if the value G of its quality characteristic is larger or smaller than a given level g. We assume that, due to the lack of precision of the measurement instrument, the measurement M of this characteristic is expressed by ∫ (G) + ξ where f is an increasing function such that the value ∫ (g 0 ) is known and ξ is a random error with mean zero and given variance. First we study the problem of the determination of a critical measure m such that a specified quality target is reached after the classification of a lot of items where each item is accepted or rejected depending on whether its measurement is smaller or greater than m. Then we analyse the problem of testing the global quality of a lot from the measurements for a example of items taken from the lot. For these two kinds of problems and for different quality targets, we propose solutions emphasizing on the case where the function ∫ is linear and the error ξ and the variable G are Gaussian. Simulation results allow to appreciate the efficiency of the different considered control procedures and their robustness with respect to deviations from the assumptions used in the theoretical derivations. (author)

  14. Mindcontrol: A web application for brain segmentation quality control.

    Science.gov (United States)

    Keshavan, Anisha; Datta, Esha; M McDonough, Ian; Madan, Christopher R; Jordan, Kesshi; Henry, Roland G

    2018-04-15

    Tissue classification plays a crucial role in the investigation of normal neural development, brain-behavior relationships, and the disease mechanisms of many psychiatric and neurological illnesses. Ensuring the accuracy of tissue classification is important for quality research and, in particular, the translation of imaging biomarkers to clinical practice. Assessment with the human eye is vital to correct various errors inherent to all currently available segmentation algorithms. Manual quality assurance becomes methodologically difficult at a large scale - a problem of increasing importance as the number of data sets is on the rise. To make this process more efficient, we have developed Mindcontrol, an open-source web application for the collaborative quality control of neuroimaging processing outputs. The Mindcontrol platform consists of a dashboard to organize data, descriptive visualizations to explore the data, an imaging viewer, and an in-browser annotation and editing toolbox for data curation and quality control. Mindcontrol is flexible and can be configured for the outputs of any software package in any data organization structure. Example configurations for three large, open-source datasets are presented: the 1000 Functional Connectomes Project (FCP), the Consortium for Reliability and Reproducibility (CoRR), and the Autism Brain Imaging Data Exchange (ABIDE) Collection. These demo applications link descriptive quality control metrics, regional brain volumes, and thickness scalars to a 3D imaging viewer and editing module, resulting in an easy-to-implement quality control protocol that can be scaled for any size and complexity of study. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

  15. Incorporating Quality Control Information in the Sensor Web

    Science.gov (United States)

    Devaraju, Anusuriya; Kunkel, Ralf; Bogena, Heye

    2013-04-01

    The rapid development of sensing technologies had led to the creation of large amounts of heterogeneous environmental observations. The Sensor Web provides a wider access to sensors and observations via common protocols and specifications. Observations typically go through several levels of quality control, and aggregation before they are made available to end-users. Raw data are usually inspected, and related quality flags are assigned. Data are gap-filled, and errors are removed. New data series may also be derived from one or more corrected data sets. Until now, it is unclear how these kinds of information can be captured in the Sensor Web Enablement (SWE) framework. Apart from the quality measures (e.g., accuracy, precision, tolerance, or confidence), the levels of observational series, the changes applied, and the methods involved must be specified. It is important that this kind of quality control information is well described and communicated to end-users to allow for a better usage and interpretation of data products. In this paper, we describe how quality control information can be incorporated into the SWE framework. Concerning this, first, we introduce the TERENO (TERrestrial ENvironmental Observatories), an initiative funded by the large research infrastructure program of the Helmholtz Association in Germany. The main goal of the initiative is to facilitate the study of long-term effects of climate and land use changes. The TERENO Online Data RepOsitORry (TEODOOR) is a software infrastructure that supports acquisition, provision, and management of observations within TERENO via SWE specifications and several other OGC web services. Next, we specify changes made to the existing observational data model to incorporate quality control information. Here, we describe the underlying TERENO data policy in terms of provision and maintenance issues. We present data levels, and their implementation within TEODOOR. The data levels are adapted from those used by

  16. New approach for quality control in manufacturing process

    Science.gov (United States)

    Hanzah, Muhammad Radhi bin; Rahim, Wan Mohd Faizal Wan Abd; Khor, C. Y.; Ishak, Muhammad Ikman; Rosli, M. U.; Jamalludin, Mohd Riduan; Zakaria, M. S.; Nawi, M. A. M.

    2017-09-01

    This study was regulated exclusively in view of theoretical aspect and further research should be done to demonstrate it in the genuine circumstance. The structure of this investigation including two industrial visits, i.e. interviews and meeting with approved staff from each organization agents. This review is cut up into two sections. Aside from the perception, little gatherings with the staffs from both organizations are held. With the subtle elements, the review is begun up. The aim of the study is characterized as to enhance the assessment strategy at quality control station to minimize defect outflow to the following client. This is to investigate the underlying factor in ebb and flow quality control framework so that another strategy to enhance quality control framework can implemented. Quality is a basic characteristic to be instated so that the end goal to fulfill clients' need is achieved. After a long hypothetical review is made, the best answer for be actualized at QG station to beat defects outflow to the following customer is by photoelectric sensor. It is reasonable, simple to keep up and has a high affectability to identify the defective items at the QG station.

  17. 10 CFR 26.167 - Quality assurance and quality control.

    Science.gov (United States)

    2010-01-01

    ... at the appropriate cutoff concentration for the compound of interest as specified in § 26.161(c) and (f), a control without the compound of interest (i.e., a certified negative control), and at least one control with one of the compounds of interest at a measurable concentration; and (ii) A...

  18. Quality charters or quality members? A control theory perspective on team charters and team performance.

    Science.gov (United States)

    Courtright, Stephen H; McCormick, Brian W; Mistry, Sal; Wang, Jiexin

    2017-10-01

    Though prevalent in practice, team charters have only recently received scholarly attention. However, most of this work has been relatively devoid of theory, and consequently, key questions about why and under what conditions team charter quality affects team performance remain unanswered. To address these gaps, we draw on macro organizational control theory to propose that team charter quality serves as a team-level "behavior" control mechanism that builds task cohesion through a structured exercise. We then juxtapose team charter quality with an "input" team control mechanism that influences the emergence of task cohesion more organically: team conscientiousness. Given their redundant effects on task cohesion, we propose that the effects of team charter quality and team conscientiousness on team performance (through task cohesion) are substitutive such that team charter quality primarily impacts team performance for teams that are low (vs. high) on conscientiousness. We test and find support for our hypotheses in a sample of 239 undergraduate self-managing project teams. Our study contributes to the groups and teams literature in the following ways: first, relative to previous studies, we take a more theory-driven approach toward understanding team charters, and in doing so, uncover when and why team charter quality impacts team performance; second, we integrate two normally disparate perspectives on team effectiveness (team development and team selection) to offer a broader perspective on how teams are "built"; and third, we introduce team charter quality as a performance-enhancing mechanism for teams lower on conscientiousness. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  19. [Post-marketing reevaluation for potential quality risk and quality control in clinical application of traditional Chinese medicines].

    Science.gov (United States)

    Li, Hong-jiao; He, Li-yun; Liu, Bao-yan

    2015-06-01

    The effective quality control in clinical practices is an effective guarantee for the authenticity and scientificity of the findings. The post-marketing reevaluation for traditional Chinese medicines (TCM) focuses on the efficacy, adverse reaction, combined medication and effective dose of drugs in the market by expanded clinical trials, and requires a larger sample size and a wider range of patients. Therefore, this increases the difficulty of quality control in clinical practices. With the experience in quality control in clinical practices for the post-marketing reevaluation for Kangbingdu oral for cold, researchers in this study reviewed the study purpose, project, scheme design and clinical practice process from an overall point of view, analyzed the study characteristics of the post-marketing reevaluation for TCMs and the quality control risks, designed the quality control contents with quality impacting factors, defined key review contents and summarized the precautions in clinical practices, with the aim to improve the efficiency of quality control of clinical practices. This study can provide reference to clinical units and quality control-related personnel in the post-marketing reevaluation for TCMs.

  20. SALE, Quality Control of Analytical Chemical Measurements

    International Nuclear Information System (INIS)

    Bush, W.J.; Gentillon, C.D.

    1985-01-01

    1 - Description of problem or function: The Safeguards Analytical Laboratory Evaluation (SALE) program is a statistical analysis program written to analyze the data received from laboratories participating in the SALE quality control and evaluation program. The system is aimed at identifying and reducing analytical chemical measurement errors. Samples of well-characterized materials are distributed to laboratory participants at periodic intervals for determination of uranium or plutonium concentration and isotopic distributions. The results of these determinations are statistically evaluated and participants are informed of the accuracy and precision of their results. 2 - Method of solution: Various statistical techniques produce the SALE output. Assuming an unbalanced nested design, an analysis of variance is performed, resulting in a test of significance for time and analyst effects. A trend test is performed. Both within- laboratory and between-laboratory standard deviations are calculated. 3 - Restrictions on the complexity of the problem: Up to 1500 pieces of data for each nuclear material sampled by a maximum of 75 laboratories may be analyzed