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Sample records for quality control method

  1. Quality Control Guidelines for SAM Chemical Methods

    Science.gov (United States)

    Learn more about quality control guidelines and recommendations for the analysis of samples using the chemistry methods listed in EPA's Selected Analytical Methods for Environmental Remediation and Recovery (SAM).

  2. Quality Control Guidelines for SAM Biotoxin Methods

    Science.gov (United States)

    Learn more about quality control guidelines and recommendations for the analysis of samples using the pathogen methods listed in EPA's Selected Analytical Methods for Environmental Remediation and Recovery (SAM).

  3. Quality Control Guidelines for SAM Radiochemical Methods

    Science.gov (United States)

    Learn more about quality control guidelines and recommendations for the analysis of samples using the radiochemistry methods listed in EPA's Selected Analytical Methods for Environmental Remediation and Recovery (SAM).

  4. Quality Control Guidelines for SAM Pathogen Methods

    Science.gov (United States)

    Learn more about quality control guidelines and recommendations for the analysis of samples using the biotoxin methods listed in EPA's Selected Analytical Methods for Environmental Remediation and Recovery (SAM).

  5. Quality Control Analytical Methods: Method Validation.

    Science.gov (United States)

    Klang, Mark G; Williams, LaVonn A

    2016-01-01

    To properly determine the accuracy of a pharmaceutical product or compounded preparation, tests must be designed specifically for that evaluation. The procedures selected must be verified through a process referred to as method validation, an integral part of any good analytical practice. The results from a method validation procedure can be used to judge the quality, reliability, and consistency of analytical results. The purpose of this article is to deliver the message of the importance of validation of a pharmaceutical product or compounded preparation and to briefly discuss the results of a lack of such validation. Copyright© by International Journal of Pharmaceutical Compounding, Inc.

  6. Developing methods of controlling quality costs

    Directory of Open Access Journals (Sweden)

    Gorbunova A. V.

    2017-01-01

    Full Text Available The article examines issues of managing quality costs, problems of applying economic methods of quality control, implementation of progressive methods of quality costs management in enterprises with the view of improving the efficiency of their evaluation and analysis. With the aim of increasing the effectiveness of the cost management mechanism, authors introduce controlling as a tool of deviation analysis from the standpoint of the process approach. A list of processes and corresponding evaluation criteria in the quality management system of enterprises is introduced. Authors also introduce the method of controlling quality costs and propose it for the practical application, which allows them to determine useful and unnecessary costs at the existing operating plant. Implementing the proposed recommendations in the system of cost management at an enterprise will allow to improve productivity of processes operating and reduce wasted expense on the quality of the process on the basis of determining values of useful and useless costs of quality according to criteria of processes functioning in the system of quality management.

  7. General Quality Control (QC) Guidelines for SAM Methods

    Science.gov (United States)

    Learn more about quality control guidelines and recommendations for the analysis of samples using the methods listed in EPA's Selected Analytical Methods for Environmental Remediation and Recovery (SAM).

  8. NMR methods for beer characterization and quality control.

    Science.gov (United States)

    Rodrigues, J E; Gil, A M

    2011-12-01

    The use of high-resolution NMR spectroscopy in the brewing industry is described; most studies having aimed at assessing the composition of beer and its raw materials and correlating it to a variety of quality parameters. First, the application of NMR to the qualitative characterization of beer is reviewed, addressing both targeted and untargeted methods and focusing on both beer extracts and direct beer analysis. A subsequent chapter addresses the NMR studies, which envisage the development of new rapid methods for beer analysis and quality control, such as site-specific natural fractionation-NMR and multivariate data analysis methods for marker search or rapid compound quantification. Finally, possible future perspectives toward a deeper and more complete understanding of beer and its brewing process are discussed. Copyright © 2012 John Wiley & Sons, Ltd.

  9. Improved statistical method for temperature and salinity quality control

    Science.gov (United States)

    Gourrion, Jérôme; Szekely, Tanguy

    2017-04-01

    Climate research and Ocean monitoring benefit from the continuous development of global in-situ hydrographic networks in the last decades. Apart from the increasing volume of observations available on a large range of temporal and spatial scales, a critical aspect concerns the ability to constantly improve the quality of the datasets. In the context of the Coriolis Dataset for ReAnalysis (CORA) version 4.2, a new quality control method based on a local comparison to historical extreme values ever observed is developed, implemented and validated. Temperature, salinity and potential density validity intervals are directly estimated from minimum and maximum values from an historical reference dataset, rather than from traditional mean and standard deviation estimates. Such an approach avoids strong statistical assumptions on the data distributions such as unimodality, absence of skewness and spatially homogeneous kurtosis. As a new feature, it also allows addressing simultaneously the two main objectives of an automatic quality control strategy, i.e. maximizing the number of good detections while minimizing the number of false alarms. The reference dataset is presently built from the fusion of 1) all ARGO profiles up to late 2015, 2) 3 historical CTD datasets and 3) the Sea Mammals CTD profiles from the MEOP database. All datasets are extensively and manually quality controlled. In this communication, the latest method validation results are also presented. The method has already been implemented in the latest version of the delayed-time CMEMS in-situ dataset and will be deployed soon in the equivalent near-real time products.

  10. Quality control analytical methods: strategies to ensure a robust quality-control microbiology program.

    Science.gov (United States)

    Griffiths, Tricia; Connors, Anne

    2013-01-01

    As the regulatory environment for compounding pharmacies continues to evolve, facilities can take immediate steps to strengthen their quality-control microbiology and environmental monitoring programs. Robust programs that are timely, comprehensive, and effective will minimize risk and help support positive patient outcomes. This article provides a roadmap for putting in place a robust quality-control microbiology program in the face of United States Pharmacopeia Chapter 797 standards, and highlights several technologies for environmental monitoring that support a successful program.

  11. Quality control methods for KOOS operational sea surface temperature products

    Institute of Scientific and Technical Information of China (English)

    YANG Chansu; KIM Sunhwa

    2016-01-01

    Sea surface temperature SST obtained from the initial version of the Korea Operational Oceanographic System (KOOS) SST satellite have low accuracy during summer and daytime. This is attributed to the diurnal warming effect. Error estimation of SST data must be carried out to use the real-time forecasting numerical model of the KOOS. This study suggests two quality control methods for the KOOS SST system. To minimize the diurnal warming effect, SSTs of areas where wind speed is higher than 5 m/s were used. Depending on the wind threshold value, KOOS SST data for August 2014 were reduced by 0.15°C. Errors in SST data are considered to be a combination of random, sampling, and bias errors. To estimate bias error, the standard deviation of bias between KOOS SSTs and climatology SSTs were used. KOOS SST data yielded an analysis error standard deviation value similar to OSTIA and NOAA NCDC (OISST) data. The KOOS SST shows lower random and sampling errors with increasing number of observations using six satellite datasets. In further studies, the proposed quality control methods for the KOOS SST system will be applied through more long-term case studies and comparisons with other SST systems.

  12. Methodical Grounds of Managing the Product Quality Control

    Directory of Open Access Journals (Sweden)

    Shapoval Olena A.

    2014-01-01

    Full Text Available The article analyses the modern state of products quality control management. It justifies a necessity of organisation of the quality control system under conditions of uninterrupted flow line production. It reveals problems connected with a low level of the products quality control management. It forms a set of factors of internal and external environments, which should be taken into account in the process of selection of a type of managerial actions by the products quality control. It considers specific features of identification of the most important factors at an enterprise on the basis of use of the matrix of strategic SWOT analysis. It offers a procedure of identification of a general assessment of factors of influence. It analyses a mechanism of use of main conceptual models, which reflect the system nature of quality management in an organisation – quality pyramids and quality loops. It proves a necessity of application of a principally new scheme of relations between the customer and enterprise, which envisages that requirements of the quality management system focus not on control and screening of semi-finished products, but on creation of conditions that exclude rejects. It considers the role of ISO 9000 in the system of quality management, which recommend the customers to make a preliminary assessment of activity of the producing enterprise.

  13. Methods for the Quality Control of Inactivated Poliovirus Vaccines.

    Science.gov (United States)

    Wilton, Thomas

    2016-01-01

    Inactivated poliovirus vaccine (IPV) plays an instrumental role in the Global Poliovirus Eradication Initiative (GPEI). The quality of IPV is controlled by assessment of the potency of vaccine batches. The potency of IPV can be assessed by both in vivo and in vitro methods. In vitro potency assessment is based upon the assessment of the quantity of the D-Antigen (D-Ag) units in an IPV. The D-Ag unit is used as a measure of potency as it is largely expressed on native infectious virions and is the protective immunogen. The most commonly used in vitro test is the indirect ELISA which is used to ensure consistency throughout production.A range of in vivo assays have been developed in monkeys, chicks, guinea pigs, mice, and rats to assess the potency of IPV. All are based on assessment of the neutralizing antibody titer within the sera of the respective animal model. The rat potency test has become the favored in vivo potency test as it shows minimal variation between laboratories and the antibody patterns of rats and humans are similar. With the development of transgenic mice expressing the human poliovirus receptor, immunization-challenge tests have been developed to assess the potency of IPVs. This chapter describes in detail the methodology of these three laboratory tests to assess the quality of IPVs.

  14. QUALITY CONTROL OF HAWTHORN TINCTURE BY HPTLC METHOD

    Directory of Open Access Journals (Sweden)

    Khokhlova KO

    2016-09-01

    Full Text Available Introduction. Hawthorn tincture is one of the most used herbal drugs at the domestic pharmaceutical market. According to the State register of drugs at the pharmaceutical market of Ukraine, there are 13 commercial offers of Hawthorn tincture from home-produced manufactures. The initial herbal raw materials for Hawthorn tincture are Hawthorn fruits, which are widespread at the territory of Ukraine. These are pharmacopoeial herbal raw material. Thus, 12 different species of Hawthorn fruits are included into monograph of Ukrainian State Pharmacopoeia (SPhU and State Pharmacopoeia of USSR XI ed. On the territory of Ukraine there are near 30 different species of Hawthorn, and the quantity of species is much arises due to its forms and hybrids. The ‘natural variability’ of bioactive substances of Hawthorn fruits of the same species and possibility of usage of many different species during manufacturing process of herbal drugs lead to the pitfalls in standardization of herbal drugs in general, and Hawthorn tincture particularly, and should be taken in mind while development of its quality control methods. For development of specific and reproducible identification method, it is necessary to ensure the number of parameters: usage of method and equipment that give reproducible results; big selections of different samples; rigorously observation of method’s procedure of implementation. The modern, automated HPTLC method of analysis was chosen for identification purpose. If standardize procedure and suitable equipment are used, the reproducible results of the method have to be obtained. The aim of this paper was development of HPTLC method for identification of Hawthorn tincture, which could be appropriated for stability study and establishment of its expire date. Materials and Methods. In research 13 samples of Hawthorn tinctures from 8 manufactures from Ukraine and Russia were analyzed. These samples were manufactured in 2010, 2014, 2015 years. The

  15. Quality control methods in accelerometer data processing: identifying extreme counts.

    Directory of Open Access Journals (Sweden)

    Carly Rich

    Full Text Available BACKGROUND: Accelerometers are designed to measure plausible human activity, however extremely high count values (EHCV have been recorded in large-scale studies. Using population data, we develop methodological principles for establishing an EHCV threshold, propose a threshold to define EHCV in the ActiGraph GT1M, determine occurrences of EHCV in a large-scale study, identify device-specific error values, and investigate the influence of varying EHCV thresholds on daily vigorous PA (VPA. METHODS: We estimated quantiles to analyse the distribution of all accelerometer positive count values obtained from 9005 seven-year old children participating in the UK Millennium Cohort Study. A threshold to identify EHCV was derived by differentiating the quantile function. Data were screened for device-specific error count values and EHCV, and a sensitivity analysis conducted to compare daily VPA estimates using three approaches to accounting for EHCV. RESULTS: Using our proposed threshold of ≥ 11,715 counts/minute to identify EHCV, we found that only 0.7% of all non-zero counts measured in MCS children were EHCV; in 99.7% of these children, EHCV comprised < 1% of total non-zero counts. Only 11 MCS children (0.12% of sample returned accelerometers that contained negative counts; out of 237 such values, 211 counts were equal to -32,768 in one child. The medians of daily minutes spent in VPA obtained without excluding EHCV, and when using a higher threshold (≥19,442 counts/minute were, respectively, 6.2% and 4.6% higher than when using our threshold (6.5 minutes; p<0.0001. CONCLUSIONS: Quality control processes should be undertaken during accelerometer fieldwork and prior to analysing data to identify monitors recording error values and EHCV. The proposed threshold will improve the validity of VPA estimates in children's studies using the ActiGraph GT1M by ensuring only plausible data are analysed. These methods can be applied to define appropriate EHCV

  16. Study on quality control method for compound Shanzha Granules

    Institute of Scientific and Technical Information of China (English)

    付延伟; 程艳芹

    2015-01-01

    Objective:To establish the quality standard of Compound Shanzha Granules. Methods:Crataegi Fructus and Cassiae Semen were identified by TLC. The contents of Autrantio- obtusin and Chrysophanol in Cassiae Semen were determined by HPLC. Results:The relevant spots on TLC plates were clear by the blank reference. The contents showed good linearitis in the range of 0.0357~0.3570μg for Autrantio- obtusin and 0.0520~0.5200μg for Chrysophanol.Conclusions:The method are simple, accurate and reproducible.

  17. A quality control method enhancement concept-Continual improvement of regulatory approved QC methods.

    Science.gov (United States)

    Åsberg, Dennis; Nilsson, Mikael; Olsson, Susanne; Samuelsson, Jörgen; Svensson, Olof; Klick, Silke; Ennis, Julie; Butterworth, Paul; Watt, Denise; Iliadou, Stavroula; Karlsson, Angelica; Walker, Joanne T; Arnot, Kate; Ealer, Norb; Hernqvist, Kerstin; Svensson, Karin; Grinell, Ali; Quist, Per-Ola; Karlsson, Anders; Fornstedt, Torgny

    2016-09-10

    Quality Control methods (QC-methods) play an important role in the overall control strategy for drug manufacturing. However, efficient life-cycle management and continual improvement are hindered due to a variety of post-approval variation legislations across territories and a lack of harmonization of the requirements. As a result, many QC-methods fall behind the technical development. Developing the QC-method in accordance with the Quality by Design guidelines gives the possibility to do continual improvements inside the original Method Operable Design Region (MODR). However, often it is necessary to do changes outside the MODR, e.g. to incorporate new technology that was not available at the time the original method was development. Here, we present a method enhancement concept which allows minor adjustments, within the same measuring principle, outside the original MODR without interaction with regulatory agencies. The feasibility of the concept is illustrated by a case study of a QC-method based on HPLC, assumed to be developed before the introduction of UHPLC, where the switch from HPLC to UHPLC is necessary as a continual improvement strategy. The concept relies on the assumption that the System Suitability Test (SST) and failure modes are relevant for other conditions outside the MODR as well when the same measuring principle is used. It follows that it should be possible to move outside the MODR as long as the SST has passed. All minor modifications of the original, approved QC-method must be re-validated according to a template given in the original submission and a statistical equivalence should be shown between the original and modified QC-methods. To summarize, revalidation is handled within the pharmaceutical quality control system according to internal change control procedures, but without interaction with regulating agencies.

  18. A unified method of inspection and quality control

    Directory of Open Access Journals (Sweden)

    P.V. Krishna Iyer

    1958-01-01

    Full Text Available It has been shown earlier that the mean and range charts used for S.Q.C. can be replaced by a single chart showing the largest and smallest values of samples taken from the machine at regular intervals. This chart designated as L-S chart has been found to be economical and efficient in many respects. The present paper shows that by modifying the sampling procedure, the S.Q.C. chart, besides providing information on the machine setting, tool wearing etc. for controlling the quality of the products collected during sampling intervals and thus enables us to dispense with 100 percent stage inspection which is in practice in the ordnance factories. The modification consists in taking one or two jobs from the machine at regular intervals and another four jobs at random from the products manufactured during every interval. The samples so selected are plotted on a chart against the specification limits. The collections during the different intervals will be accepted if all the four jobs are within the specification limits; otherwise screening will be done. Condition of the machine is judged mainly from the jobs taken from it. The experimental investigations conducted at Gun and Shell Factory, Cossipore show that this procedure works as effectively as the L-S chart and cent per cent inspection

  19. The meat product quality control by a polarimetric method

    Science.gov (United States)

    Blokhina, Anastasia A.; Ryzhova, Victoria A.; Korotaev, Valery V.; Kleshchenok, Maksim A.

    2017-05-01

    Analysis of the polarization characteristics of the scattered radiation of biological tissues in some cases provides a qualitatively new results in the study of biological samples. These results can be used in medicine and food industry. As a result of the work, it was determined that the high concentration of scattering particles, the nonuniformity of their dimensions, forms make the task of creating an adequate optical model of a biotissue quite difficult, though many interesting tissue properties can be potentially studied by means of polarized light. In this case, the method for control the freshness of meat samples is considered for by obtaining the Stokes parameters of the polarized radiation scattered forward by the meat product.

  20. High oleic sunflower biodiesel: quality control and different purification methods

    Directory of Open Access Journals (Sweden)

    Pighinelli, Anna L.M.T.

    2011-06-01

    Full Text Available The objective of the present work is to evaluate the production of biodiesel using ethanol and sunflower oil. The extraction of the sunflower oil was evaluated first. An experimental design was used to estimate the influence of the independent variables grain temperature (25º to 110ºC and expeller rotation (85 to 119rpm on the crude oil. The best result obtained was 68.38%, achieved with a rotation from 100 to 115rpm, grain temperature ranging from 25º to 30ºC and moisture content of around 7%. The next study consisted of transesterification, evaluating the influence of the ethanol, oil molar ratio and the catalyst concentration (sodium methylate on the ester-rich phase yield. The highest yield was 98.39% obtained with a molar ratio of 9:1 and 3% catalyst. An experiment was then carried out on a small reactor and the biodiesel produced was purified by three different methods: acidified water, silica and distillation. The quality aspects of the purified biodiesel samples were evaluated according to the Brazilian specifications for biodiesel, and distillation was shown to be the best method of purification.

    El objetivo del presente trabajo es evaluar la producción de biodiesel usando etanol y aceite de girasol. La extracción del aceite de girasol fue evaluada primero. Un diseño experimental fue usado para estimar la influencia de las variables independientes: temperatura del grano (25º a 110ºC y rotación del expeller (85 a 119 rpm en la obtención del aceite crudo. El mejor resultado obtenido fue un 68,38%, conseguido con una rotación de 100 a 115 rpm, una temperatura del grano de 25º a 30ºC y un contenido de humedad de alrededor del 7%. El siguiente estudio mediante transesterificación, evaluó la influencia de la relación molar etanol: aceite y concentración de catalizador (metilato sódico en el rendimiento de la fase rica en esteres. El rendimiento más alto fue 98,39% obtenido con una relación molar de 9.1 y 3% de

  1. Real Time Quality Control Methods for Cued EMI Data Collection

    Science.gov (United States)

    2016-01-12

    stages as well as during the final demonstration of the technology. Thanks to Kevin Kingdon, Dave Lutes, and Barry Zelt (with Sky Research at the time...aforementioned feature quality metrics. The first example shows inversion results for data collected over a 60mm mortar at 30cm burial depth (Figure 6

  2. A simple method for the quality control of [F-18]FDG

    DEFF Research Database (Denmark)

    Koziorowski, J.

    2010-01-01

    Most automated synthesis modules produce [F-18]FDG within half an hour, but the quality control involving up to three separate methods and three different analytical systems is time consuming. The use of HPLC, TLC, and GC for the quality control of [F-18]FDG is both time consuming and expensive...

  3. A simple method for the quality control of [(18)F]FDG

    DEFF Research Database (Denmark)

    Koziorowski, J

    2010-01-01

    Most automated synthesis modules produce [(18)F]FDG within half an hour, but the quality control involving up to three separate methods and three different analytical systems is time consuming. The use of HPLC, TLC, and GC for the quality control of [(18)F]FDG is both time consuming and expensive...

  4. Systems and methods for data quality control and cleansing

    Science.gov (United States)

    Wenzel, Michael; Boettcher, Andrew; Drees, Kirk; Kummer, James

    2016-05-31

    A method for detecting and cleansing suspect building automation system data is shown and described. The method includes using processing electronics to automatically determine which of a plurality of error detectors and which of a plurality of data cleansers to use with building automation system data. The method further includes using processing electronics to automatically detect errors in the data and cleanse the data using a subset of the error detectors and a subset of the cleansers.

  5. Development of Photogrammetric Methods of Stress Analysis and Quality Control

    CERN Document Server

    Kubik, D L; Kubik, Donna L.; Greenwood, John A.

    2003-01-01

    A photogrammetric method of stress analysis has been developed to test thin, nonstandard windows designed for hydrogen absorbers, major components of a muon cooling channel. The purpose of the absorber window tests is to demonstrate an understanding of the window behavior and strength as a function of applied pressure. This is done by comparing the deformation of the window, measured via photogrammetry, to the deformation predicted by finite element analysis (FEA). FEA analyses indicate a strong sensitivity of strain to the window thickness. Photogrammetric methods were chosen to measure the thickness of the window, thus providing data that are more accurate to the FEA. This, plus improvements made in hardware and testing procedures, resulted in a precision of 5 microns in all dimensions and substantial agreement with FEA predictions.

  6. A Simplified but Effective Method for the Quality Control of Medicinal ...

    African Journals Online (AJOL)

    A Simplified but Effective Method for the Quality Control of Medicinal Plants by Planar ... peoples, the safety and effectivity is frequently not such a big concern. With more people collecting and distributing herbal medicine, the offered product is ...

  7. 30 CFR 28.33 - Quality control test methods, equipment, and records; review by MSHA; revocation of approval.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality control test methods, equipment, and... Quality Control § 28.33 Quality control test methods, equipment, and records; review by MSHA; revocation... control test methods, equipment, and records, and to interview any employee or agent of the applicant in...

  8. QC-Chain: fast and holistic quality control method for next-generation sequencing data.

    Directory of Open Access Journals (Sweden)

    Qian Zhou

    Full Text Available Next-generation sequencing (NGS technologies have been widely used in life sciences. However, several kinds of sequencing artifacts, including low-quality reads and contaminating reads, were found to be quite common in raw sequencing data, which compromise downstream analysis. Therefore, quality control (QC is essential for raw NGS data. However, although a few NGS data quality control tools are publicly available, there are two limitations: First, the processing speed could not cope with the rapid increase of large data volume. Second, with respect to removing the contaminating reads, none of them could identify contaminating sources de novo, and they rely heavily on prior information of the contaminating species, which is usually not available in advance. Here we report QC-Chain, a fast, accurate and holistic NGS data quality-control method. The tool synergeticly comprised of user-friendly tools for (1 quality assessment and trimming of raw reads using Parallel-QC, a fast read processing tool; (2 identification, quantification and filtration of unknown contamination to get high-quality clean reads. It was optimized based on parallel computation, so the processing speed is significantly higher than other QC methods. Experiments on simulated and real NGS data have shown that reads with low sequencing quality could be identified and filtered. Possible contaminating sources could be identified and quantified de novo, accurately and quickly. Comparison between raw reads and processed reads also showed that subsequent analyses (genome assembly, gene prediction, gene annotation, etc. results based on processed reads improved significantly in completeness and accuracy. As regard to processing speed, QC-Chain achieves 7-8 time speed-up based on parallel computation as compared to traditional methods. Therefore, QC-Chain is a fast and useful quality control tool for read quality process and de novo contamination filtration of NGS reads, which could

  9. Comparison of bar pattern and edge method for MTF measurement in radiology quality control

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez, M.; Alves, A.F.F; Bacchim Neto, F.A.; Pavan, A.L.M.; Rosa, M.E.D.; Miranda, J.R.A.; Pina, D.R. de, E-mail: drpina@fmb.unesp.br [Universidade Estadual Paulista Julio de Mesquita Filho (UNESP), Botucatu, SP (Brazil)

    2015-08-15

    Spatial resolution is one of the parameters that is routinely checked during acceptance procedures and regular quality control measurements. The spatial resolution of a radiographic imaging device is most appropriately expressed in terms of its modulation transfer function (MTF), which indicates the decline of detector spatial resolution with spatial frequency. Traditionally used methods of MTF measurement involve imaging either a narrow slit or a sharp edge to obtain the detector line spread function (LSF), whose frequency transform leads to the MTF. In this work is presented a study of the measurement of the limiting spatial resolution using the MTF method and the line-pair bar-pattern method. Our aim is to compare the bar-pattern method with the MTF method and then evaluate what method is the best for the dairy quality control tests and when is better to perform one test or other. These acquisition procedures were tested according to its reproducibility and variation due to noise. (author)

  10. A GPS-Based Control Method for Load Sharing and Power Quality Improvement in Microgrids

    DEFF Research Database (Denmark)

    Golsorkhi, Mohammad; Lu, Dylan; Savaghebi, Mehdi;

    2016-01-01

    This paper proposes a novel control method for accurate sharing of load current among the Distributed Energy Resources (DER) and high power quality operating in islanded ac microgrids. This control scheme is based on hierarchical structure comprising of decentralized primary controllers and a cen....... The secondary controller produces compensation signals at fundamental and dominant harmonics to improve the voltage quality at a sensitive load bus. Experimental results are presented to validate the efficacy of the proposed method.......This paper proposes a novel control method for accurate sharing of load current among the Distributed Energy Resources (DER) and high power quality operating in islanded ac microgrids. This control scheme is based on hierarchical structure comprising of decentralized primary controllers......-I) droop characteristic. The droop coefficient, which acts as a virtual resistance, is adaptively changed as a function of peak current. This strategy not only simplifies the control design but also enables faster dynamics and higher accuracy of current sharing especially at high loading conditions...

  11. A New Quality Control Method base on IRMCD for Wind Profiler Observation towards Future Assimilation Application

    Science.gov (United States)

    Chen, Min; Zhang, Yu

    2017-04-01

    A wind profiler network with a total of 65 profiling radars was operated by the MOC/CMA in China until July 2015. In this study, a quality control procedure is constructed to incorporate the profiler data from the wind-profiling network into the local data assimilation and forecasting system (BJRUC). The procedure applies a blacklisting check that removes stations with gross errors and an outlier check that rejects data with large deviations from the background. Instead of the bi-weighting method, which has been commonly implemented in outlier elimination for one-dimensional scalar observations, an outlier elimination method is developed based on the iterated reweighted minimum covariance determinant (IRMCD) for multi-variate observations such as wind profiler data. A quality control experiment is separately performed for subsets containing profiler data tagged in parallel with/without rain flags at every 00UTC/12UTC from 20 June to 30 Sep 2015. From the results, we find that with the quality control, the frequency distributions of the differences between the observations and model background become more Gaussian-like and meet the requirements of a Gaussian distribution for data assimilation. Further intensive assessment for each quality control step reveals that the stations rejected by blacklisting contain poor data quality, and the IRMCD rejects outliers in a robust and physically reasonable manner.

  12. A Control Law Design Method Facilitating Control Power, Robustness, Agility, and Flying Qualities Tradeoffs: CRAFT

    Science.gov (United States)

    Murphy, Patrick C.; Davidson, John B.

    1998-01-01

    A multi-input, multi-output control law design methodology, named "CRAFT", is presented. CRAFT stands for the design objectives addressed, namely, Control power, Robustness, Agility, and Flying Qualities Tradeoffs. The methodology makes use of control law design metrics from each of the four design objective areas. It combines eigenspace assignment, which allows for direct specification of eigenvalues and eigenvectors, with a graphical approach for representing the metrics that captures numerous design goals in one composite illustration. Sensitivity of the metrics to eigenspace choice is clearly displayed, enabling the designer to assess the cost of design tradeoffs. This approach enhances the designer's ability to make informed design tradeoffs and to reach effective final designs. An example of the CRAFT methodology applied to an advanced experimental fighter and discussion of associated design issues are provided.

  13. Impact Assessment of Various Methods for Control of Synchronous Generator Excitation on Quality of Transient Processes

    Directory of Open Access Journals (Sweden)

    Y. D. Filipchik

    2011-01-01

    Full Text Available The paper considers an impact of various methods for control of an exciting current pertaining to a synchronous generator on the nature of transient processes. A control algorithm for the exciting current in relation to changes in sliding and acceleration of a generator rotor has been proposed in the paper. The algorithm makes it possible to improve quality of the transient processes due to reduction of oscillation range concerning as an active power so a δ-angle as well.

  14. Control of cheese quality – strategies and methods for delivery of consistent sensory product quality at the point of consumption

    OpenAIRE

    Kraggerud, Hilde

    2011-01-01

    An effective approach to quality control is an important issue for a food producer, as consumers expect consistent delivery of products. Two important strategies for control of food product end quality was discussed in this thesis: Process regulation and Statistical Process control (SPC). Extensive experiments were carried out in order to demonstrate different aspects of control of cheese quality. The sensory quality of a product is of great importance, as it is directly perceived at consu...

  15. Quality Control Applications

    CERN Document Server

    Chorafas, Dimitris N

    2013-01-01

    Quality control is a constant priority in electrical, mechanical, aeronautical, and nuclear engineering – as well as in the vast domain of electronics, from home appliances to computers and telecommunications. Quality Control Applications provides guidance and valuable insight into quality control policies; their methods, their implementation, constant observation and associated technical audits. What has previously been a mostly mathematical topic is translated here for engineers concerned with the practical implementation of quality control. Once the fundamentals of quality control are established, Quality Control Applications goes on to develop this knowledge and explain how to apply it in the most effective way. Techniques are described and supported using relevant, real-life, case studies to provide detail and clarity for those without a mathematical background. Among the many practical examples, two case studies dramatize the importance of quality assurance: A shot-by-shot analysis of the errors made ...

  16. Reliable evaluation method of quality control for compressive strength of concrete

    Institute of Scientific and Technical Information of China (English)

    CHEN Kuen-suan; SUNG Wen-pei; SHIH Ming-hsiang

    2005-01-01

    Concrete in reinforced concrete structure (RC) is generally under significant compressive stress load. To guarantee required quality and ductility, various tests have to be conducted to measure the concrete's compressive strength based on ACI(American Concrete Institute) code. Investigations of recent devastating collapses of structures around the world showed that some of the collapses directly resulted from the poor quality of the concrete. The lesson learned from these tragedies is that guaranteeing high quality of concrete is one of the most important factors ensuring the safety of the reinforced concrete structure.In order to ensure high quality of concrete, a new method for analyzing and evaluating the concrete production process is called for.In this paper, the indices of fit and stable degree are proposed as basis to evaluate the fitness and stability of concrete's compressive strength. These two indices are combined to define and evaluate the quality index of the compressive strength of concrete. Principles of statistics are used to derive the best estimators of these indices. Based on the outcome of the study, a concrete compressive strength quality control chart is proposed as a tool to help the evaluation process. Finally, a new evaluation procedure to assess the quality control capability of the individual concrete manufacturer is also proposed.

  17. An express method for optimally tuning an analog controller with respect to integral quality criteria

    Science.gov (United States)

    Golinko, I. M.; Kovrigo, Yu. M.; Kubrak, A. I.

    2014-03-01

    An express method for optimally tuning analog PI and PID controllers is considered. An integral quality criterion with minimizing the control output is proposed for optimizing control systems. The suggested criterion differs from existing ones in that the control output applied to the technological process is taken into account in a correct manner, due to which it becomes possible to maximally reduce the expenditure of material and/or energy resources in performing control of industrial equipment sets. With control organized in such manner, smaller wear and longer service life of control devices are achieved. A unimodal nature of the proposed criterion for optimally tuning a controller is numerically demonstrated using the methods of optimization theory. A functional interrelation between the optimal controller parameters and dynamic properties of a controlled plant is numerically determined for a single-loop control system. The results obtained from simulation of transients in a control system carried out using the proposed and existing functional dependences are compared with each other. The proposed calculation formulas differ from the existing ones by a simple structure and highly accurate search for the optimal controller tuning parameters. The obtained calculation formulas are recommended for being used by specialists in automation for design and optimization of control systems.

  18. Statistical methods for quality assurance basics, measurement, control, capability, and improvement

    CERN Document Server

    Vardeman, Stephen B

    2016-01-01

    This undergraduate statistical quality assurance textbook clearly shows with real projects, cases and data sets how statistical quality control tools are used in practice. Among the topics covered is a practical evaluation of measurement effectiveness for both continuous and discrete data. Gauge Reproducibility and Repeatability methodology (including confidence intervals for Repeatability, Reproducibility and the Gauge Capability Ratio) is thoroughly developed. Process capability indices and corresponding confidence intervals are also explained. In addition to process monitoring techniques, experimental design and analysis for process improvement are carefully presented. Factorial and Fractional Factorial arrangements of treatments and Response Surface methods are covered. Integrated throughout the book are rich sets of examples and problems that help readers gain a better understanding of where and how to apply statistical quality control tools. These large and realistic problem sets in combination with the...

  19. Meta-QC-Chain: comprehensive and fast quality control method for metagenomic data.

    Science.gov (United States)

    Zhou, Qian; Su, Xiaoquan; Jing, Gongchao; Ning, Kang

    2014-02-01

    Next-generation sequencing (NGS) technology has revolutionized and significantly impacted metagenomic research. However, the NGS data usually contains sequencing artifacts such as low-quality reads and contaminating reads, which will significantly compromise downstream analysis. Many quality control (QC) tools have been proposed, however, few of them have been verified to be suitable or efficient for metagenomic data, which are composed of multiple genomes and are more complex than other kinds of NGS data. Here we present a metagenomic data QC method named Meta-QC-Chain. Meta-QC-Chain combines multiple QC functions: technical tests describe input data status and identify potential errors, quality trimming filters poor sequencing-quality bases and reads, and contamination screening identifies higher eukaryotic species, which are considered as contamination for metagenomic data. Most computing processes are optimized based on parallel programming. Testing on an 8-GB real dataset showed that Meta-QC-Chain trimmed low sequencing-quality reads and contaminating reads, and the whole quality control procedure was completed within 20 min. Therefore, Meta-QC-Chain provides a comprehensive, useful and high-performance QC tool for metagenomic data. Meta-QC-Chain is publicly available for free at: http://computationalbioenergy.org/meta-qc-chain.html.

  20. Hyperspectral Imaging as a Rapid Quality Control Method for Herbal Tea Blends

    Directory of Open Access Journals (Sweden)

    Majolie Djokam

    2017-03-01

    Full Text Available In South Africa, indigenous herbal teas are enjoyed due to their distinct taste and aroma. The acclaimed health benefits of herbal teas include the management of chronic diseases such as hypertension and diabetes. Quality control of herbal teas has become important due to the availability of different brands of varying quality and the production of tea blends. The potential of hyperspectral imaging as a rapid quality control method for herbal tea blends from rooibos (Aspalathus linearis, honeybush (Cyclopia intermedia, buchu (Agathosma Betulina and cancerbush (Sutherlandia frutescens was investigated. Hyperspectral images of raw materials and intact tea bags were acquired using a sisuChema shortwave infrared (SWIR hyperspectral pushbroom imaging system (920–2514 nm. Principal component analysis (PCA plots showed clear discrimination between raw materials. Partial least squares discriminant analysis (PLS-DA models correctly predicted the raw material constituents of each blend and accurately determined the relative proportions. The results were corroborated independently using ultra-high performance liquid chromatography coupled to mass spectrometry (UHPLC-MS. This study demonstrated the application of hyperspectral imaging coupled with chemometric modelling as a reliable, rapid and non-destructive quality control method for authenticating herbal tea blends and to determine relative proportions in a tea bag.

  1. Automated quality control methods for sensor data: a novel observatory approach

    Directory of Open Access Journals (Sweden)

    J. R. Taylor

    2012-12-01

    Full Text Available National and international networks and observatories of terrestrial-based sensors are emerging rapidly. As such, there is demand for a standardized approach to data quality control, as well as interoperability of data among sensor networks. The National Ecological Observatory Network (NEON has begun constructing their first terrestrial observing sites with 60 locations expected to be distributed across the US by 2017. This will result in over 14 000 automated sensors recording more than > 100 Tb of data per year. These data are then used to create other datasets and subsequent "higher-level" data products. In anticipation of this challenge, an overall data quality assurance plan has been developed and the first suite of data quality control measures defined. This data-driven approach focuses on automated methods for defining a suite of plausibility test parameter thresholds. Specifically, these plausibility tests scrutinize data range, persistence, and stochasticity on each measurement type by employing a suite of binary checks. The statistical basis for each of these tests is developed and the methods for calculating test parameter thresholds are explored here. While these tests have been used elsewhere, we apply them in a novel approach by calculating their relevant test parameter thresholds. Finally, implementing automated quality control is demonstrated with preliminary data from a NEON prototype site.

  2. Automated quality control methods for sensor data: a novel observatory approach

    Directory of Open Access Journals (Sweden)

    J. R. Taylor

    2013-07-01

    Full Text Available National and international networks and observatories of terrestrial-based sensors are emerging rapidly. As such, there is demand for a standardized approach to data quality control, as well as interoperability of data among sensor networks. The National Ecological Observatory Network (NEON has begun constructing their first terrestrial observing sites, with 60 locations expected to be distributed across the US by 2017. This will result in over 14 000 automated sensors recording more than > 100 Tb of data per year. These data are then used to create other datasets and subsequent "higher-level" data products. In anticipation of this challenge, an overall data quality assurance plan has been developed and the first suite of data quality control measures defined. This data-driven approach focuses on automated methods for defining a suite of plausibility test parameter thresholds. Specifically, these plausibility tests scrutinize the data range and variance of each measurement type by employing a suite of binary checks. The statistical basis for each of these tests is developed, and the methods for calculating test parameter thresholds are explored here. While these tests have been used elsewhere, we apply them in a novel approach by calculating their relevant test parameter thresholds. Finally, implementing automated quality control is demonstrated with preliminary data from a NEON prototype site.

  3. A review on tomato authenticity: quality control methods in conjunction with multivariate analysis (chemometrics).

    Science.gov (United States)

    Arvanitoyannis, Ioannis S; Vaitsi, Olga B

    2007-01-01

    Authenticity and traceability have been two of the most important issues in the food chain. Authenticity in particular, is closely related with both food quality and safety issues. Vegetables stand for a category of foods heavily affected by adulteration either in terms of geographic origin (national or international level) or production methods (organic or conventional production, fertilizers, pesticides, genetically modified vegetables). This review aims at addressing most of the currently applied methods for ensuring quality control of vegetables; a) instrumental: ion chromatography, high pressure liquid chromatography, atomic absorption spectrophotometry, electronic nose and mass spectroscopy and b) sensory analysis. The results of all the above mentioned methods were analyzed by means of multivariate analysis (principal component analysis, discriminant analysis, cluster analysis, canonical analysis, and factor analysis). All ensuing results and conclusions are summarized in eight comprehensive tables.

  4. Study on Rear-end Real-time Data Quality Control Method of Regional Automatic Weather Station

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    [Objective] The aim was to study the rear-end real-time data quality control method of regional automatic weather station. [Method] The basic content and steps of rear-end real-time data quality control of regional automatic weather station were introduced. Each element was treated with systematic quality control procedure. The existence of rear-end real time data of regional meteorological station in Guangxi was expounded. Combining with relevant elements and linear changes, improvement based on traditiona...

  5. Internal quality control of PCR-based genotyping methods: practical experiences

    DEFF Research Database (Denmark)

    Bladbjerg, Else-Marie; Gram, Jørgen; Jespersen, Jørgen

    2002-01-01

    Internal quality control programmes for genetic analyses are needed. We have focused on quality control aspects of selected polymorphism analyses used in thrombosis research. DNA was isolated from EDTA-blood (n = 500) and analysed for 18 polymorphisms by polymerase chain reaction (PCR), i...... because of positive reagent blanks (controls (Control of data handling revealed 0.1% reading mistakes and 0.5% entry mistakes. Based on our experiences, we propose an internal quality control programme...

  6. Molecular methods for microbiological quality control of meat and meat products: a review.

    Science.gov (United States)

    Gokulakrishnan, P; Vergis, Jess

    2015-01-01

    Achieving food safety is a global health goal and the food-borne diseases take a major check on global health. Therefore, detection of microbial pathogens in food is the solution to the prevention and recognition of problems related to health and safety. Conventional and standard bacterial detection methods such as culture and colony counting methods and immunology-based methods may take up to several hours or even a few days to yield a result. Obviously, this is inadequate, and recently many researchers are focusing towards the progress of rapid diagnostic methods. The advent of molecular techniques has led to the development of a diverse array of assay for quality control of meat and meat products. Rapid analysis using DNA hybridization and amplification techniques offer more sensitivity and specificity to get results than culture based methods as well as dramatic reduction in the time to get results. Many methods have also achieved the high level automation, facilitating their application as routine sample screening assays. This review is intended to provide an overview of the molecular methods for microbiological quality control of meat and meat products.

  7. Quality Prediction and Control of Reducing Pipe Based on EOS-ELM-RPLS Mathematics Modeling Method

    Directory of Open Access Journals (Sweden)

    Dong Xiao

    2014-01-01

    Full Text Available The inspection of inhomogeneous transverse and longitudinal wall thicknesses, which determines the quality of reducing pipe during the production of seamless steel reducing pipe, is lags and difficult to establish its mechanism model. Aiming at the problems, we proposed the quality prediction model of reducing pipe based on EOS-ELM-RPLS algorithm, which taking into account the production characteristics of its time-varying, nonlinearity, rapid intermission, and data echelon distribution. Key contents such as analysis of data time interval, solving of mean value, establishment of regression model, and model online prediction were introduced and the established prediction model was used in the quality prediction and iteration control of reducing pipe. It is shown through experiment and simulation that the prediction and iteration control method based on EOS-ELM-RPLS model can effectively improve the quality of steel reducing pipe, and, moreover, its maintenance cost was low and it has good characteristics of real time, reliability, and high accuracy.

  8. [Coronary artery bypass surgery: methods of performance monitoring and quality control].

    Science.gov (United States)

    Albert, A; Sergeant, P; Ennker, J

    2009-10-01

    The strength of coronary bypass operations depends on the preservation of their benefits regarding freedom of symptoms, quality of life and survival, over decades. Significant variability of the results of an operative intervention according to the hospital or the operating surgeon is considered a weakness in the procedure. The external quality insurance tries to reach a transparent service providing market through hospital ranking comparability. Widely available information and competition will promote the improvement of the whole quality. The structured dialog acts as a control instrument for the BQS (Federal Quality Insurance). It is launched in case of deviations from the standard references or statistically significant differences between the results of the operations in any hospital and the average notational results. In comparison to the external control the hospital internal control has greater ability to reach a medically useful statement regarding the results of the treatment and to correct the mistakes in time. An online information portal based on a departmental databank (DataWarehouse, DataMart) is an attractive solution for the physician in order to get transparently and timely informed about the variability in the performance.The individual surgeon significantly influences the short- and long-term treatment results. Accordingly, selection, targeted training and performance measurements are necessary.Strict risk management and failure analysis of individual cases are included in the methods of internal quality control aiming to identify and correct the inadequacies in the system and the course of treatment. According to the international as well as our own experience, at least 30% of the mortalities after bypass operations are avoidable. A functioning quality control is especially important in minimally invasive interventions because they are often technically more demanding in comparison to the conventional procedures. In the field of OPCAB surgery

  9. An Overview on Novel Microbial Determination Methods in Pharmaceutical and Food Quality Control

    Directory of Open Access Journals (Sweden)

    Mahboob Nemati

    2016-09-01

    Full Text Available Traditional microbiological methods tend to be labor-intensive and time-consuming. Rapid and novel methods in microbiological tests provide more sensitive, precise and reproducible results compared with conventional methods. In microbiology, the most rapid testing methods belong to the field of biotechnology such as PCR, ELISA, ATP bioluminescence and etc. Nevertheless impedance microbiology, biosensors and analytical procedures to determine microbial constituents are of significance. The present review article was conducted using internet databases and related scientific literatures and articles that provide information on developments in the rapid methods in microbiology. The main focus is on the application of rapid methods in microbial quality control of pharmaceutical products. Reviewed literature showed that rapid methods and automation in microbiology is an advanced area for studying and applying of improved methods in the early detection, and characterization of microorganisms and their products in food, pharmaceutical and cosmetic industrials as well as environmental monitoring and clinical applications. It can be concluded that rapid methods and automation in microbiology should continue as potent and efficient technologies to develop the novel tests to be performed in the future because of the ever-increasing concerns about the safety of food and pharmaceutical products. However the main issues to be considered are the scale up of developed methods and the regulatory requirements.

  10. An Overview on Novel Microbial Determination Methods in Pharmaceutical and Food Quality Control

    Science.gov (United States)

    Nemati, Mahboob; Hamidi, Aliasghar; Maleki Dizaj, Solmaz; Javaherzadeh, Vahid; Lotfipour, Farzaneh

    2016-01-01

    Traditional microbiological methods tend to be labor-intensive and time-consuming. Rapid and novel methods in microbiological tests provide more sensitive, precise and reproducible results compared with conventional methods. In microbiology, the most rapid testing methods belong to the field of biotechnology such as PCR, ELISA, ATP bioluminescence and etc. Nevertheless impedance microbiology, biosensors and analytical procedures to determine microbial constituents are of significance. The present review article was conducted using internet databases and related scientific literatures and articles that provide information on developments in the rapid methods in microbiology. The main focus is on the application of rapid methods in microbial quality control of pharmaceutical products. Reviewed literature showed that rapid methods and automation in microbiology is an advanced area for studying and applying of improved methods in the early detection, and characterization of microorganisms and their products in food, pharmaceutical and cosmetic industrials as well as environmental monitoring and clinical applications. It can be concluded that rapid methods and automation in microbiology should continue as potent and efficient technologies to develop the novel tests to be performed in the future because of the ever-increasing concerns about the safety of food and pharmaceutical products. However the main issues to be considered are the scale up of developed methods and the regulatory requirements. PMID:27766214

  11. Validation of a liquid chromatographic method for the pharmaceutical quality control of products containing elacridar

    Directory of Open Access Journals (Sweden)

    Emilia Sawicki

    2016-08-01

    Full Text Available Many anticancer drugs have an impaired bioavailability and poor brain penetration because they are substrates to drug efflux pumps such as P-glycoprotein and Breast Cancer Resistance Protein. Elacridar is a strong inhibitor of these two drug efflux pumps and therefore has great potential to improve oral absorption and brain penetration of many anticancer drugs. Currently, a clinical formulation of elacridar is unavailable and therefore the pharmaceutical development of a drug product is highly warranted. This also necessitates the availability of an analytical method for its quality control. A reverse-phase high-performance liquid chromatographic method with ultraviolet detection was developed for the pharmaceutical quality control of products containing elacridar as the active pharmaceutical ingredient. The analytical method was validated for linearity, accuracy, precision, selectivity, carry-over, stability of stock and reference solutions, stability of the final extract, stability-indicating capability and impurity testing. We found that elacridar is unstable in aqueous solutions that are exposed to light because a hydroxylation product of elacridar is formed. Therefore, sample solutions with elacridar must be protected from light.

  12. Validation of a liquid chromatographic method for the pharmaceutical quality control of products containing elacridar$

    Institute of Scientific and Technical Information of China (English)

    Emilia Sawicki; Michel J. Hillebrand; Hilde Rosing; Jan H.M. Schellens; Bastiaan Nuijen; Jos H. Beijnen

    2016-01-01

    Many anticancer drugs have an impaired bioavailability and poor brain penetration because they are sub-strates to drug efflux pumps such as P-glycoprotein and Breast Cancer Resistance Protein. Elacridar is a strong inhibitor of these two drug efflux pumps and therefore has great potential to improve oral absorption and brain penetration of many anticancer drugs. Currently, a clinical formulation of elacridar is unavailable and therefore the pharmaceutical development of a drug product is highly warranted. This also necessitates the availability of an analytical method for its quality control. A reverse-phase high-performance liquid chro-matographic method with ultraviolet detection was developed for the pharmaceutical quality control of products containing elacridar as the active pharmaceutical ingredient. The analytical method was validated for linearity, accuracy, precision, selectivity, carry-over, stability of stock and reference solutions, stability of the final extract, stability-indicating capability and impurity testing. We found that elacridar is unstable in aqueous solutions that are exposed to light because a hydroxylation product of elacridar is formed. Therefore, sample solutions with elacridar must be protected from light.

  13. Internal quality control of PCR-based genotyping methods in research studies and patient diagnostics

    DEFF Research Database (Denmark)

    Bladbjerg, Else-Marie; Gram, Jørgen; Jespersen, Jørgen

    2002-01-01

    Genetic analyses are increasingly integrated in the clinical laboratory, and internal quality control programmes are needed. We have focused on quality control aspects of selected polymorphism analyses used in thrombosis research. DNA was isolated from EDTA-blood (n = 500) by ammonium acetate pre...

  14. Internal quality control of PCR-based genotyping methods: practical experiences

    DEFF Research Database (Denmark)

    Bladbjerg, Else-Marie; Gram, Jørgen; Jespersen, Jørgen

    2002-01-01

    Internal quality control programmes for genetic analyses are needed. We have focused on quality control aspects of selected polymorphism analyses used in thrombosis research. DNA was isolated from EDTA-blood (n = 500) and analysed for 18 polymorphisms by polymerase chain reaction (PCR), i.e. rest...

  15. Quality Control Method for a Micro-Nano-Channel Microfabricated Device

    Science.gov (United States)

    Grattoni, Alessandro; Ferrari, Mauro; Li, Xuewu

    2012-01-01

    A variety of silicon-fabricated devices is used in medical applications such as drug and cell delivery, and DNA and protein separation and analysis. When a fluidic device inlet is connected to a compressed gas reservoir, and the outlet is at a lower pressure, a gas flow occurs through the membrane toward the outside. The method relies on the measurement of the gas pressure over the elapsed time inside the upstream and downstream environments. By knowing the volume of the upstream reservoir, the gas flow rate through the membrane over the pressure drop can be calculated. This quality control method consists of measuring the gas flow through a device and comparing the results with a standard curve, which can be obtained by testing standard devices. Standard devices can be selected through a variety of techniques, both destructive and nondestructive, such as SEM, AFM, and standard particle filtration.

  16. Application of risk analysis and quality control methods for improvement of lead molding process

    Directory of Open Access Journals (Sweden)

    H. Gołaś

    2016-10-01

    Full Text Available The aim of the paper is to highlight the significance of implication of risk analysis and quality control methods for the improvement of parameters of lead molding process. For this reason, Fault Mode and Effect Analysis (FMEA was developed in the conceptual stage of a new product TC-G100-NR. However, the final product was faulty (a complete lack of adhesion of brass insert to leak regardless of the previously defined potential problem and its preventive action. It contributed to the recognition of root causes, corrective actions and change of production parameters. It showed how these methods, level of their organization, systematic and rigorous study affect molding process parameters.

  17. The New Approach of Using Image and Range Based Methods for Quality Control of Dimension Stone

    Science.gov (United States)

    Levytskyi, Volodymyr

    2017-06-01

    The basis for the quality control of commodity dimension stone blocks for mining industry is the study of fracturing. The identification of fracturing in rock masses is one of the most important aspects in rock mass modelling. Traditional methods for determination properties of fracturing are difficult and hazardous. This paper describes a new approach of fracturing identification, based on image and range data, which realized by image processing and special software. In this article describes a method using new computer algorithms that allow for automated identification and calculation of fracturing parameters. Different digital filters for image processing and mathematical dependences are analyzed. The digital imaging technique has the potential for being used in real time applications. The purpose of this paper is the accurate and fast mapping of fracturing in some walls of the Bukinsky gabbro deposit.

  18. COAL QUALITY CONTROL

    Institute of Scientific and Technical Information of China (English)

    孟祥瑞

    1998-01-01

    Coal storing and loading have much more influence on coal quality. In the paper, a goalprogramming model has been constructed to determine the ideal quantity extracting from stockpileand silos and a quality control model is inferred under the guidance of maximum theory ofdispersed number and practice methods are given to meet production demand, with which a coalmine has achieved a better tech-economic result.

  19. Improved method to obtain pfaffic acid as a marker for quality control

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigues, Marili Villa Nova; Vedovello, Amanda; Rodrigues, Rodney Alexandre Ferreira; Montanari Junior, Ilio; Rehder, Vera Lucia Garcia, E-mail: rodney@cpqba.unicamp.br [Centro Pluridisciplinar de Pesquisas Quimicas, Biologicas e Agricolas, Universidade Estadual de Campinas, SP (Brazil)

    2013-09-01

    Pfaffic acid, a marker of Hebanthe eriantha (Brazilian ginseng), was first isolated in 1983 but is not yet commercially available. This lack of availability compromises the quality control of this plant and its derivatives. This paper proposes a process for pfaffic acid isolation from roots of H. eriantha at a purity suitable for analytical purposes. The steps involved in this process included extraction, hydrolysis, fractionation and purification by preparative HPLC. This process led to isolation of pfaffic acid with a chromatographic purity of 98.5% in a 0.25% yield from dried roots of H. eriantha; this yield is more than forty times higher than that of the current method in the literature. (author)

  20. Improved method to obtain pfaffic acid as a marker for quality control

    Directory of Open Access Journals (Sweden)

    Marili Villa Nova Rodrigues

    2013-01-01

    Full Text Available Pfaffic acid, a marker of Hebanthe eriantha (Brazilian ginseng, was first isolated in 1983 but is not yet commercially available. This lack of availability compromises the quality control of this plant and its derivatives. This paper proposes a process for pfaffic acid isolation from roots of H. eriantha at a purity suitable for analytical purposes. The steps involved in this process included extraction, hydrolysis, fractionation and purification by preparative HPLC. This process led to isolation of pfaffic acid with a chromatographic purity of 98.5% in a 0.25% yield from dried roots of H. eriantha; this yield is more than forty times higher than that of the current method in the literature.

  1. Measuring the quality of infection control in Dutch nursing homes using a standardized method; the Infection prevention RIsk Scan (IRIS)

    NARCIS (Netherlands)

    Willemsen, I.; Nelson-Melching, J.; Hendriks, Y.; Mulders, A.; Verhoeff, S.; Kluytmans-Vandenbergh, M.; Kluytmans, J.

    2014-01-01

    BACKGROUND: We developed a standardised method to assess the quality of infection control in Dutch Nursing Home (NH), based on a cross-sectional survey that visualises the results. The method was called the Infection control RIsk Infection Scan (IRIS). We tested the applicability of this new tool in

  2. Ultrasonic resonator technology as a new quality control method evaluating gelatin nanoparticles.

    Science.gov (United States)

    Fuchs, Sebastian; Winter, Gerhard; Coester, Conrad

    2010-05-01

    Nanomedicine is a quickly evolving field where more and more possible applications become evident and start entering clinical trials or even the market. However, the analytic methods are not always able to keep pace with the new formulations' demands. One example of a promising medical implementation is oligodeoxynucleotide (ODN) delivery by gelatin nanoparticles (GNPs). Currently, quality control is dependent on either some time consuming or destructive spectrometric, chromatographic or electrophoretic methods. A possible enlargement of the portfolio by Ultrasonic Resonator Technology (URT) is investigated here by subjecting plain GNPs in various sizes and concentrations as well as ODN-loaded GNPs to URT analysis. If calibrated by photon correlation spectroscopy (PCS) and other spectroscopy methods for each single nanoparticle system parameter, URT is an efficient and non-destructive technique and serves as a broad characterization method. URT is emphasized to play a possible future part in the size, concentration and ODN loading monitoring, e.g. of gelatin nanoparticles in the course of formulation development.

  3. Sensory and rapid instrumental methods as a combined tool for quality control of cooked ham

    Directory of Open Access Journals (Sweden)

    Sara Barbieri

    2016-11-01

    This study can be considered a first application of this combined approach that could represent a suitable and fast method to verify if the meat product purchased by consumer match its description in terms of compliance with the claimed quality.

  4. Evaluating methods for ranking differentially expressed genes applied to microArray quality control data

    Directory of Open Access Journals (Sweden)

    Shimizu Kentaro

    2011-06-01

    Full Text Available Abstract Background Statistical methods for ranking differentially expressed genes (DEGs from gene expression data should be evaluated with regard to high sensitivity, specificity, and reproducibility. In our previous studies, we evaluated eight gene ranking methods applied to only Affymetrix GeneChip data. A more general evaluation that also includes other microarray platforms, such as the Agilent or Illumina systems, is desirable for determining which methods are suitable for each platform and which method has better inter-platform reproducibility. Results We compared the eight gene ranking methods using the MicroArray Quality Control (MAQC datasets produced by five manufacturers: Affymetrix, Applied Biosystems, Agilent, GE Healthcare, and Illumina. The area under the curve (AUC was used as a measure for both sensitivity and specificity. Although the highest AUC values can vary with the definition of "true" DEGs, the best methods were, in most cases, either the weighted average difference (WAD, rank products (RP, or intensity-based moderated t statistic (ibmT. The percentages of overlapping genes (POGs across different test sites were mainly evaluated as a measure for both intra- and inter-platform reproducibility. The POG values for WAD were the highest overall, irrespective of the choice of microarray platform. The high intra- and inter-platform reproducibility of WAD was also observed at a higher biological function level. Conclusion These results for the five microarray platforms were consistent with our previous ones based on 36 real experimental datasets measured using the Affymetrix platform. Thus, recommendations made using the MAQC benchmark data might be universally applicable.

  5. Novel method for the evaluation of data quality based on fuzzy control

    Institute of Scientific and Technical Information of China (English)

    Ban Xiaojuan; Ning Shurong; Xu Zhaolin; Cheng Peng

    2008-01-01

    One of the goals of data collection is preparing for decision-making, so high quality requirement must be satisfied. Rational evaluation of data quality is an effective way to identify data problem in time, and the quality of data after this evaluation is satisfactory with the requirement of decision maker. A fuzzy neural network based research method of data quality evaluation is proposed. First, the criteria for the evaluation of data quality are selected to construct the fuzzy sets of evaluating grades, and then by using the learning ability of NN, the objective evaluation of membership is carried out, which can be used for the effective evaluation of data quality. This research has been used in the platform of data report of national compulsory education outlay guarantee' from the Chinese Ministry of Education. This method can be used for the effective evaluation of data quality worldwide, and the data quality situation can be found out more completely, objectively, and in better time by using the method.

  6. A New Region-of-interest Coding Method to Control the Relative Quality of Progressive Decoded Images

    Institute of Scientific and Technical Information of China (English)

    LI Ji-liang; FANG Xiang-zhong; ZHANG Dong-dong

    2007-01-01

    Based on the ideas of controlling relative quality and rearranging bitplanes, a new ROI coding method for JPEG2000 was proposed, which shifts and rearranges bitplanes in units of bitplane groups.It can code arbitrary shaped ROI without shape coding, and reserve almost arbitrary percent of background information.It also can control the relative quality of progressive decoded images.In addition, it is easy to be implemented and has low computational cost.

  7. Quantifying viruses and bacteria in wastewater—Results, interpretation methods, and quality control

    Science.gov (United States)

    Francy, Donna S.; Stelzer, Erin A.; Bushon, Rebecca N.; Brady, Amie M.G.; Mailot, Brian E.; Spencer, Susan K.; Borchardt, Mark A.; Elber, Ashley G.; Riddell, Kimberly R.; Gellner, Terry M.

    2011-01-01

    Membrane bioreactors (MBR), used for wastewater treatment in Ohio and elsewhere in the United States, have pore sizes small enough to theoretically reduce concentrations of protozoa and bacteria, but not viruses. Sampling for viruses in wastewater is seldom done and not required. Instead, the bacterial indicators Escherichia coli (E. coli) and fecal coliforms are the required microbial measures of effluents for wastewater-discharge permits. Information is needed on the effectiveness of MBRs in removing human enteric viruses from wastewaters, particularly as compared to conventional wastewater treatment before and after disinfection. A total of 73 regular and 28 quality-control (QC) samples were collected at three MBR and two conventional wastewater plants in Ohio during 23 regular and 3 QC sampling trips in 2008-10. Samples were collected at various stages in the treatment processes and analyzed for bacterial indicators E. coli, fecal coliforms, and enterococci by membrane filtration; somatic and F-specific coliphage by the single agar layer (SAL) method; adenovirus, enterovirus, norovirus GI and GII, rotavirus, and hepatitis A virus by molecular methods; and viruses by cell culture. While addressing the main objective of the study-comparing removal of viruses and bacterial indicators in MBR and conventional plants-it was realized that work was needed to identify data analysis and quantification methods for interpreting enteric virus and QC data. Therefore, methods for quantifying viruses, qualifying results, and applying QC data to interpretations are described in this report. During each regular sampling trip, samples were collected (1) before conventional or MBR treatment (post-preliminary), (2) after secondary or MBR treatment (post-secondary or post-MBR), (3) after tertiary treatment (one conventional plant only), and (4) after disinfection (post-disinfection). Glass-wool fiber filtration was used to concentrate enteric viruses from large volumes, and small

  8. An application of classical and instrumental methods of analysis in quality control of beer

    Directory of Open Access Journals (Sweden)

    Rajković Miloš B.

    2015-01-01

    Full Text Available In order to control the quality of beer and raw materials for production of beer in Belgrade Beer Industry (BIP, water is analyzed (city, technological and demineralized water. Measurements of pH values indicated the increased pH values in the sample of tehnological water, which had no impact on wort hopping, since the tested samples of wort, young beer and final product had a pH value within the expected range. After processing city water, a sample of tehnological water was found with increased carbonate hardness, which is caused by the increased content of sodium hydrogen carbonate. Analysing the titration alkalinity, titration acidity and buffering power, it was found that the alkalinity was decreasing which is in accordance with the determination of pH values of wort and beer samples (young beer and final product. Analyzing the content of anions and cations in the examined water samples, it has been shown that the concentration of these examinated anions (Cl-, NO3 -, SO4 2- and PO4 3- and cations (NH4 +, Na+, K+, Ca2+, Mg2+ are within the limits prescribed by the Regulations on hygienic safety of drinking water, and thus by the Regulations of quality and other requirements for beer. The contents of anions in wort and beer samples (young beer and final product were determined by ion chromatography method. The contents of sulphate and nitrate ions were within the recommended limits. The concentration of chloride ions was above 150 mg/dm3, which may have an impact on the sensory properties of beer, while changes in the content of phosphate ions were insignificant. [Projekat Ministarstva nauke Republike Srbije, br. III 43009

  9. A new method for quality control of Chinese rawinsonde wind observations

    Science.gov (United States)

    Liao, Jie; Wang, Bin; Li, Qingxiang

    2014-11-01

    In 2006, the National Meteorological Information Center (NMIC) of the China Meteorological Administration (CMA) developed its real-time quality control (QC) system of rawinsonde observations coming from the Global Telecommunications System (GTS) and established the Global Upper-air Report Dataset, which, with the NMIC B01 format, is generally referred to as the B01 dataset and updated on a daily basis. However, when the B01 dataset is applied in climate analysis, some wind errors as well as some accurate values with incorrect error marks are found. To improve the quality and usefulness of Chinese rawinsonde wind observations, a new QC method (NewQC) is proposed in this paper. Different from the QC approach used for B01 datasets, the NewQC includes two vertical-wind-shear checks to analyze the vertical consistency of winds, in which the constant height level winds are used as reference data for the QC of mandatory pressure level winds. Different threshold values are adopted in the wind shear checks for different stations and different vertical levels. Several typical examples of QC of different error types by the new algorithm are shown and its performance with respect to 1980-2008 observational data is statistically evaluated. Compared with the radiosonde QC algorithms used in both the Meteorological Assimilation Data Ingest System (MADIS, http://madis.noaa.gov/madis_raob_qc.html) of the National Oceanic and Atmospheric Administration (NOAA) and the B01 dataset, the NewQC shows higher accuracy and better reliability, particularly when used to judge successive observation errors.

  10. A simplified but effective method for the quality control of medicinal plants by planar chromatography.

    Science.gov (United States)

    Eloff, J N; Ntloedibe, D T; van Brummelen, R

    2011-01-01

    Three of the factors limiting the rational use of herbal medicine are uncertainty on effectivity, uncertainty on safety and variation in quality of the product. Because many herbal medicines have been used over centuries by indigenous peoples, the safety and effectivity is frequently not such a big concern. With more people collecting and distributing herbal medicine, the offered product is however, frequently not what the label indicates either through a genuine mistake, but also through fraud especially where expensive herbal medicine is concerned. Some wrong identifications have already led to serious side effects and deaths. Planar chromatography or thin layer chromatography [TLC] is widely used to verify the identity of plant extracts by determining the chemical fingerprint of the extracts. In a leading publication 17 different extractants, 41 solvent systems and 44 spray reagents have been used to verify the identity of important herbal preparations. We investigated whether a simplified system could not be developed to aid small laboratories in identifying different herbal medicines. We compared the efficacy of different extractants, identified and developed three TLC solvent systems that would separate compounds with low, medium and high polarity and then also investigated the use of several spray reagents. With acetone as extractant and benzene:ethanol:ammonia [9:1:0.1], chloroform:ethylacetate:formic acid [5:4:1] and ethylacetate:methanol:water [10:1.35:1] as TLC solvent system and vanillin-sulphuric acid as spray reagent the identity of 81 samples of more than 50 herbal preparations could be verified on the basis of the chromatograms. The same product from different suppliers usually gave similar chromatograms. More importantly in several cases it was clear that products with the same label were so different that a mistake must have occurred in the labelling. This method has found application in the quality control of the most important African medicinal

  11. FABRIC QUALITY CONTROL SYSTEMS

    Directory of Open Access Journals (Sweden)

    Özlem KISAOĞLU

    2006-02-01

    Full Text Available Woven fabric quality depends on yarn properties at first, then weaving preparation and weaving processes. Defect control of grey and finished fabric is done manually on the lighted tables or automatically. Fabrics can be controlled by the help of the image analysis method. In image system the image of fabrics can be digitized by video camera and after storing controlled by the various processing. Recently neural networks, fuzzy logic, best wavelet packet model on automatic fabric inspection are developed. In this study the advantages and disadvantages of manual and automatic, on-line fabric inspection systems are given comparatively.

  12. Statistical Methods for Quality Control of Steel Coils Manufacturing Process using Generalized Linear Models

    Science.gov (United States)

    García-Díaz, J. Carlos

    2009-11-01

    Fault detection and diagnosis is an important problem in process engineering. Process equipments are subject to malfunctions during operation. Galvanized steel is a value added product, furnishing effective performance by combining the corrosion resistance of zinc with the strength and formability of steel. Fault detection and diagnosis is an important problem in continuous hot dip galvanizing and the increasingly stringent quality requirements in automotive industry has also demanded ongoing efforts in process control to make the process more robust. When faults occur, they change the relationship among these observed variables. This work compares different statistical regression models proposed in the literature for estimating the quality of galvanized steel coils on the basis of short time histories. Data for 26 batches were available. Five variables were selected for monitoring the process: the steel strip velocity, four bath temperatures and bath level. The entire data consisting of 48 galvanized steel coils was divided into sets. The first training data set was 25 conforming coils and the second data set was 23 nonconforming coils. Logistic regression is a modeling tool in which the dependent variable is categorical. In most applications, the dependent variable is binary. The results show that the logistic generalized linear models do provide good estimates of quality coils and can be useful for quality control in manufacturing process.

  13. Methods and applications of statistics in engineering, quality control, and the physical sciences

    CERN Document Server

    Balakrishnan, N

    2011-01-01

    Inspired by the Encyclopedia of Statistical Sciences, Second Edition (ESS2e), this volume presents a concise, well-rounded focus on the statistical concepts and applications that are essential for understanding gathered data in the fields of engineering, quality control, and the physical sciences. The book successfully upholds the goals of ESS2e by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioner in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and analyzing data across diverse subject areas within these three disciplines, including operations research, chemistry, physics, the earth sciences, electrical engineering, and quality assurance. In addition, techniques related to survey methodology, computational statistics, and operations research are discussed, where applicable. Topics of coverage include: optimal and stochastic control, arti...

  14. An application of classical and instrumental methods of analysis in quality control of beer

    OpenAIRE

    Rajković Miloš B.; Sredović-Ignjatović Ivana D.; Ignjatović Ljubiša M.; Nedović Viktor A.; Prijić Slobodan M.

    2015-01-01

    In order to control the quality of beer and raw materials for production of beer in Belgrade Beer Industry (BIP), water is analyzed (city, technological and demineralized water). Measurements of pH values indicated the increased pH values in the sample of tehnological water, which had no impact on wort hopping, since the tested samples of wort, young beer and final product had a pH value within the expected range. After processing city water, a sample of te...

  15. REGULATION AND ROLLING QUALITY CONTROL ON THE BASIS OF STATISTICAL METHODS

    Directory of Open Access Journals (Sweden)

    A. N. Polobovets

    2009-01-01

    Full Text Available It is shown that introduction of statistical method of control will allow to reduce efforts for production, delivery of the samples to the laboratory of mechanical testing, and to reduce the expenses as well.

  16. Quality control analytical methods: microbial limit tests for nonsterile pharmaceuticals, Part 1.

    Science.gov (United States)

    Vu, Nicole; Lou, Jessica R; Kupiec, Thomas C

    2014-01-01

    Contamination of pharmaceuticals with microorganisms may lead to deleterious effects on the therapeutic properties of the drug, and may potentially cause injuries to intended recipients. Cases of contaminated nonsterile products have been reported in increasing numbers, and often associated with the presence of objectionable microorganisms. Methods for detection of these organisms are described in three major Pharmacopeias. Their functions and their limitations in the examination of microbiological quality for nonsterile products will be reviewed in this report.

  17. Sensory and rapid instrumental methods as a combined tool for quality control of cooked ham.

    Science.gov (United States)

    Barbieri, Sara; Soglia, Francesca; Palagano, Rosa; Tesini, Federica; Bendini, Alessandra; Petracci, Massimiliano; Cavani, Claudio; Gallina Toschi, Tullia

    2016-11-01

    In this preliminary investigation, different commercial categories of Italian cooked pork hams have been characterized using an integrated approach based on both sensory and fast instrumental measurements. For these purposes, Italian products belonging to different categories (cooked ham, "selected" cooked ham and "high quality" cooked ham) were evaluated by sensory descriptive analysis and by the application of rapid tools such as image analysis by an "electronic eye" and texture analyzer. The panel of trained assessors identified and evaluated 10 sensory descriptors able to define the quality of the products. Statistical analysis highlighted that sensory characteristics related to appearance and texture were the most significant in discriminating samples belonged to the highest (high quality cooked hams) and the lowest (cooked hams) quality of the product whereas the selected cooked hams, showed intermediate characteristics. In particular, high quality samples were characterized, above all, by the highest intensity of pink intensity, typical appearance and cohesiveness, and, at the same time, by the lowest intensity of juiciness; standard cooked ham samples showed the lowest intensity of all visual attributes and the highest value of juiciness, whereas the intermediate category (selected cooked ham) was not discriminated from the other. Also physical-rheological parameters measured by electronic eye and texture analyzer were effective in classifying samples. In particular, the PLS model built with data obtained from the electronic eye showed a satisfactory performance in terms of prediction of the pink intensity and presence of fat attributes evaluated during the sensory visual phase. This study can be considered a first application of this combined approach that could represent a suitable and fast method to verify if the meat product purchased by consumer match its description in terms of compliance with the claimed quality.

  18. A simple and sensitive quality control method of the anaerobic atmosphere for identification and antimicrobial susceptibility testing of anaerobic bacteria

    DEFF Research Database (Denmark)

    Justesen, Tage; Justesen, Ulrik Stenz

    2013-01-01

    The maintenance of a strict anaerobic atmosphere is essential for the culture of strict anaerobic bacteria. We describe a simple and sensitive quality control method of the anaerobic atmosphere, based on the measurement of the zone diameter around a 5-μg metronidazole disk when testing an aerotol...

  19. A Quadrupole Dalton-based multi-attribute method for product characterization, process development, and quality control of therapeutic proteins.

    Science.gov (United States)

    Xu, Weichen; Jimenez, Rod Brian; Mowery, Rachel; Luo, Haibin; Cao, Mingyan; Agarwal, Nitin; Ramos, Irina; Wang, Xiangyang; Wang, Jihong

    2017-08-14

    During manufacturing and storage process, therapeutic proteins are subject to various post-translational modifications (PTMs), such as isomerization, deamidation, oxidation, disulfide bond modifications and glycosylation. Certain PTMs may affect bioactivity, stability or pharmacokinetics and pharmacodynamics profile and are therefore classified as potential critical quality attributes (pCQAs). Identifying, monitoring and controlling these PTMs are usually key elements of the Quality by Design (QbD) approach. Traditionally, multiple analytical methods are utilized for these purposes, which is time consuming and costly. In recent years, multi-attribute monitoring methods have been developed in the biopharmaceutical industry. However, these methods combine high-end mass spectrometry with complicated data analysis software, which could pose difficulty when implementing in a quality control (QC) environment. Here we report a multi-attribute method (MAM) using a Quadrupole Dalton (QDa) mass detector to selectively monitor and quantitate PTMs in a therapeutic monoclonal antibody. The result output from the QDa-based MAM is straightforward and automatic. Evaluation results indicate this method provides comparable results to the traditional assays. To ensure future application in the QC environment, this method was qualified according to the International Conference on Harmonization (ICH) guideline and applied in the characterization of drug substance and stability samples. The QDa-based MAM is shown to be an extremely useful tool for product and process characterization studies that facilitates facile understanding of process impact on multiple quality attributes, while being QC friendly and cost-effective.

  20. Quality control methods in accelerometer data processing: defining minimum wear time.

    Directory of Open Access Journals (Sweden)

    Carly Rich

    Full Text Available BACKGROUND: When using accelerometers to measure physical activity, researchers need to determine whether subjects have worn their device for a sufficient period to be included in analyses. We propose a minimum wear criterion using population-based accelerometer data, and explore the influence of gender and the purposeful inclusion of children with weekend data on reliability. METHODS: Accelerometer data obtained during the age seven sweep of the UK Millennium Cohort Study were analysed. Children were asked to wear an ActiGraph GT1M accelerometer for seven days. Reliability coefficients(r of mean daily counts/minute were calculated using the Spearman-Brown formula based on the intraclass correlation coefficient. An r of 1.0 indicates that all the variation is between- rather than within-children and that measurement is 100% reliable. An r of 0.8 is often regarded as acceptable reliability. Analyses were repeated on data from children who met different minimum daily wear times (one to 10 hours and wear days (one to seven days. Analyses were conducted for all children, separately for boys and girls, and separately for children with and without weekend data. RESULTS: At least one hour of wear time data was obtained from 7,704 singletons. Reliability increased as the minimum number of days and the daily wear time increased. A high reliability (r = 0.86 and sample size (n = 6,528 was achieved when children with ≥ two days lasting ≥10 hours/day were included in analyses. Reliability coefficients were similar for both genders. Purposeful sampling of children with weekend data resulted in comparable reliabilities to those calculated independent of weekend wear. CONCLUSION: Quality control procedures should be undertaken before analysing accelerometer data in large-scale studies. Using data from children with ≥ two days lasting ≥10 hours/day should provide reliable estimates of physical activity. It's unnecessary to include only children

  1. Software product quality control

    CERN Document Server

    Wagner, Stefan

    2013-01-01

    Quality is not a fixed or universal property of software; it depends on the context and goals of its stakeholders. Hence, when you want to develop a high-quality software system, the first step must be a clear and precise specification of quality. Yet even if you get it right and complete, you can be sure that it will become invalid over time. So the only solution is continuous quality control: the steady and explicit evaluation of a product's properties with respect to its updated quality goals.This book guides you in setting up and running continuous quality control in your environment. Star

  2. Bootstrap Signal-to-Noise Confidence Intervals: An Objective Method for Subject Exclusion and Quality Control in ERP Studies

    Science.gov (United States)

    Parks, Nathan A.; Gannon, Matthew A.; Long, Stephanie M.; Young, Madeleine E.

    2016-01-01

    Analysis of event-related potential (ERP) data includes several steps to ensure that ERPs meet an appropriate level of signal quality. One such step, subject exclusion, rejects subject data if ERP waveforms fail to meet an appropriate level of signal quality. Subject exclusion is an important quality control step in the ERP analysis pipeline as it ensures that statistical inference is based only upon those subjects exhibiting clear evoked brain responses. This critical quality control step is most often performed simply through visual inspection of subject-level ERPs by investigators. Such an approach is qualitative, subjective, and susceptible to investigator bias, as there are no standards as to what constitutes an ERP of sufficient signal quality. Here, we describe a standardized and objective method for quantifying waveform quality in individual subjects and establishing criteria for subject exclusion. The approach uses bootstrap resampling of ERP waveforms (from a pool of all available trials) to compute a signal-to-noise ratio confidence interval (SNR-CI) for individual subject waveforms. The lower bound of this SNR-CI (SNRLB) yields an effective and objective measure of signal quality as it ensures that ERP waveforms statistically exceed a desired signal-to-noise criterion. SNRLB provides a quantifiable metric of individual subject ERP quality and eliminates the need for subjective evaluation of waveform quality by the investigator. We detail the SNR-CI methodology, establish the efficacy of employing this approach with Monte Carlo simulations, and demonstrate its utility in practice when applied to ERP datasets. PMID:26903849

  3. Kaizen method for esophagectomy patients: improved quality control, outcomes, and decreased costs.

    Science.gov (United States)

    Iannettoni, Mark D; Lynch, William R; Parekh, Kalpaj R; McLaughlin, Kelley A

    2011-04-01

    The majority of costs associated with esophagectomy are related to the initial 3 days of hospital stay requiring intensive care unit stays, ventilator support, and intraoperative time. Additional costs arise from hospital-based services. The major cost increases are related to complications associated with the procedure. We attempted to define these costs and identify expense management by streamlining care through strict adherence to patient care maps, operative standardization, and rapid discharge planning to reduce variability. Utilizing methods of Kaizen philosophy we evaluated all processes related to the entire experience of esophageal resection. This process has taken over 5 years to achieve, with quality and cost being tracked over this time period. Cost analysis included expenses related to intensive care unit, anesthesia, disposables, and hospital services. Quality improvement measures were related to intraoperative complications, in-hospital complications, and postoperative outcomes. The Institutional Review Board approved the use of anonymous data from standard clinical practice because no additional treatment was planned (observational study). Utilizing a continuous process improvement methodology, a 43% reduction in cost per case has been achieved with a significant increase in contribution margin for esophagectomy. The length of stay has been reduced from 14 days to 5. With intraoperative and postoperative standardization the leak rate has dropped from 12% to less than 3% to no leaks in our current Kaizen modification of care in our last 64 patients. Utilizing lean manufacturing techniques and continuous process evaluation we have attempted to eliminate variability, standardized the phases of care resulting in improved outcomes, decreased length of stay, and improved contribution margins. These Kaizen improvements require continuous interventions, strict adherence to care maps, and input from all levels for quality improvements. Copyright © 2011 The

  4. Checking quality control?

    DEFF Research Database (Denmark)

    Brodersen, Lars

    2005-01-01

    How is quality control doing within the community of GIS, web-services based on geo-information, GI etc.?......How is quality control doing within the community of GIS, web-services based on geo-information, GI etc.?...

  5. A comprehensive strategy using chromatographic profiles combined with chemometric methods: Application to quality control of Polygonum cuspidatum Sieb. et Zucc.

    Science.gov (United States)

    Gao, Fangyuan; Xu, Zihua; Wang, Weizhong; Lu, Guocai; Vander Heyden, Yvan; Zhou, Tingting; Fan, Guorong

    2016-09-30

    For the strict quality control of herbs, a comprehensive strategy based on chromatographic profiles and chemometric methods which could reliably select quantitative indices, robustly quantitate multi-markers and systematically compare different chemometric methods was proposed and successfully applied to the quality analysis of P. cuspidatum. Based on the construction of chromatographic profiles by an efficient accelerated solvent extraction (ASE) and reliable high-performance liquid chromatography-ultraviolet (HPLC-UV) methods, different chemometric methods were employed, namely similarity analyses (SA), hierarchical clustering analysis (HCA) and linear discriminant analysis (LDA). The differences in classification of herb samples were studied for the first time. To reasonably determine the quality of herbs and evaluate different chemometric methods, a comprehensive strategy containing three key steps was performed including selection of quantitative indices, development of a reliable quantification method and adoption of an easily calculated and visible parameter. The quantitative method which was acceptable with good linearity with correlation coefficients >0.9995 and satisfactory repeatability (RSD<1.5%), precision (RSD<2.84%), reproducibility (RSD<2.88%), stability (RSD<2.85%) and recoveries (91.5%-105.6%, RSD<2.83%) was applied to quality evaluation of fourteen batches of the P. cuspidatum samples through simultaneous quantitative determination of fifteen marker compounds. The limits of quantitation of fifteen compounds ranged from 1 to 60μg/ml. From the results of the quality evaluation, it was found that the different calculation theories of the chemometric methods resulted in the variation of classifiers of samples: SA classified samples through the mean values and HCA & LDA classified similar objects.

  6. High oleic sunflower bio diesel: quality control and different purification methods

    Energy Technology Data Exchange (ETDEWEB)

    Pighlinelli, A. L. M. T.; Ferrari, R. A.; Miguel, A. M. R. O.; Park, K. J.

    2011-07-01

    The objective of the present work is to evaluate the production of bio diesel using ethanol and sunflower oil. The extraction of the sunflower oil was evaluated first. An experimental design was used to estimate the influence of the independent variables grain temperature (25 degree centigrade to 110 degree centigrade) and expelled rotation (85 to 119rpm) on the crude oil. The best result obtained was 68.38%, achieved with a rotation from 100 to 115rpm, grain temperature ranging from 25 degree centigrade to 30 degree centigrade and moisture content of around 7%. The next study consisted of transesterification, evaluating the influence of the ethanol, oil molar ratio and the catalyst concentration (sodium methylate) on the ester-rich phase yield. The highest yield was 98.39% obtained with a molar ratio of 9:1 and 3% catalyst. An experiment was then carried out on a small reactor and the bio diesel produced was purified by three different methods: acidified water, silica and distillation. The quality aspects of the purified bio diesel samples were evaluated according to the Brazilian specifications for bio diesel, and distillation was shown to be the best method of purification. (Author) 28 refs.

  7. Control Method for Unified Power Quality Conditioner Using Fuzzy Based Nine-Switch Power Conditioner

    Directory of Open Access Journals (Sweden)

    K.Gowthami

    2015-10-01

    Full Text Available A nine-switch power converter having two sets of out-put terminals was recently proposed in place of the traditional back-to-back power converter that uses 12 switches in total. The nine-switch converter has already been proven to have certain advantages, in addition to its component saving topological feature. Despite these advantages, the nine-switch converter has so far found limited applications due to its many perceived performance tradeoffs like requiring an oversized dc-link capacitor, limited amplitude sharing, and constrained phase shift between its two sets of output terminals. Instead of accepting these tradeoffs as limitations, a nineswitch power conditioner is proposed here that virtually “converts” most of these topological short comings into interesting performance advantages. Aiming further to reduce its switching losses, an appropriate discontinuous modulation scheme is proposed and studied here in detail to doubly ensure that maxi-mal reduction of commutations is achieved. With an appropriately designed control scheme then incorporated, the nine-switch converter is shown to favorably raise the overall power quality in experiment, hence justifying its role as a power conditioner at a reduced semiconductor cost.

  8. A Novel Control Method for Unified Power Quality Conditioner Using Nine-Switch Power Conditioner

    Directory of Open Access Journals (Sweden)

    B.Narendra,

    2015-05-01

    Full Text Available A nine-switch power converter having two sets of out-put terminals was recently proposed in place of the traditional back-to-back power converter that uses 12 switches in total. The nine-switch converter has already been proven to have certain advantages, in addition to its component saving topological feature. Despite these advantages, the nine-switch converter has so far found limited applications due to its many perceived performance tradeoffs like requiring an oversized dc-link capacitor, limited amplitude sharing, and constrained phase shift between its two sets of output terminals. Instead of accepting these tradeoffs as limitations, a nineswitch power conditioner is proposed here that virtually “converts” most of these topological short comings into interesting performance advantages. Aiming further to reduce its switching losses, an appropriate discontinuous modulation scheme is proposed and studied here in detail to doubly ensure that maxi-mal reduction of commutations is achieved. With an appropriately designed control scheme then incorporated, the nine-switch converter is shown to favorably raise the overall power quality in experiment, hence justifying its role as a power conditioner at a reduced semiconductor cost.

  9. Alternating irrigation water quality as a method to control solute concentrations and mass fluxes below irrigated fields: A numerical study

    Science.gov (United States)

    Russo, David

    2016-05-01

    The aim of the present numerical study was to extend the data-driven protocol for the control of soil salinity, to control chloride and nitrate concentrations and mass fluxes below agricultural fields irrigated with treated waste water (TWW). The protocol is based on alternating irrigation water quality between TWW and desalinized water (DSW), guided by solute concentrations at soil depth, zs. Two different schemes, the first requires measurements of soil solution concentrations of chloride and nitrate at zs, while, the second scheme requires only measurements of soil solution EC at zs, were investigated. For this purpose, 3-D numerical simulations of flow and transport were performed for variably saturated, spatially heterogeneous, flow domains located at two different field sites. The sites differ in crop type, irrigation method, and in their lithology; these differences, in turn, considerably affect the performance of the proposed schemes, expressed in terms of their ability to reduce solute concentrations that drained below the root zone. Results of the analyses suggest that the proposed data-driven schemes allow the use of low-quality water for irrigation, while minimizing the consumption of high-quality water to a level, which, for given climate, soil, crop, irrigation method, and water quality, may be determined by the allowable nitrate and chloride concentrations in the groundwater. The results of the present study indicate that with respect to the diminution of groundwater contamination by chloride and nitrate, the more data demanding, first scheme is superior the second scheme.

  10. Microbiological water methods: quality control measures for Federal Clean Water Act and Safe Drinking Water Act regulatory compliance.

    Science.gov (United States)

    Root, Patsy; Hunt, Margo; Fjeld, Karla; Kundrat, Laurie

    2014-01-01

    Quality assurance (QA) and quality control (QC) data are required in order to have confidence in the results from analytical tests and the equipment used to produce those results. Some AOAC water methods include specific QA/QC procedures, frequencies, and acceptance criteria, but these are considered to be the minimum controls needed to perform a microbiological method successfully. Some regulatory programs, such as those at Code of Federal Regulations (CFR), Title 40, Part 136.7 for chemistry methods, require additional QA/QC measures beyond those listed in the method, which can also apply to microbiological methods. Essential QA/QC measures include sterility checks, reagent specificity and sensitivity checks, assessment of each analyst's capabilities, analysis of blind check samples, and evaluation of the presence of laboratory contamination and instrument calibration and checks. The details of these procedures, their performance frequency, and expected results are set out in this report as they apply to microbiological methods. The specific regulatory requirements of CFR Title 40 Part 136.7 for the Clean Water Act, the laboratory certification requirements of CFR Title 40 Part 141 for the Safe Drinking Water Act, and the International Organization for Standardization 17025 accreditation requirements under The NELAC Institute are also discussed.

  11. AUTOMATION OF QUALITY CONTROL OF MILK HOMOGENIZATION BY ULTRASONIC SPECTROSCOPY METHODS

    Directory of Open Access Journals (Sweden)

    V. K. Bityukov

    2015-01-01

    Full Text Available The paper deals with the possibility of determining homogenization degree of milk and dairy products using ultrasonic vibrations absorption spectra. Advantages of this method application in automated manufacturing systems were examined. Theoretical background of the method, as well as the possibility of determining the distribution of the fat globules in milk, depending on their sizes were substantiated. We derived mathematical equations, showing the relationship between the homogenization degree of dairy products and the acoustic properties of the medium, such as the propagation velocity of ultrasonic vibrations in the medium tested and the absorption coefficient in the medium at a specific frequency of the ultrasonic impact and medium temperature. It was shown that the measurement of the propagation of the milk acoustic properties in frequency, evaluation of their density function of the relaxation times spectrum, and then from the relaxation times to the particles masses allow operational control of the fat globules masses distribution in fractions. Theoretical studies were confirmed by experimental research carrying out whose results demonstrate clearly the dependence of absorption degree of ultrasonic vibrations on the degree of milk homogenization. The dependence between the estimates of the relaxation spectra and the first two moments of the statistical distribution of milk fat globules, which demonstrated their relationship was studied. Possible improvements the method under consideration to increase the reliability of the results obtained were proposed.

  12. Quality control MIC ranges used for telavancin with application of a revised CLSI reference broth microdilution method.

    Science.gov (United States)

    Ross, James E; Mendes, Rodrigo E; Jones, Ronald N

    2014-09-01

    The telavancin broth microdilution susceptibility testing method was revised, which provides MIC results lower than those obtained by the previous method. This study was performed to reestablish the quality control ranges for telavancin when tested against the strains (updated MIC range) Staphylococcus aureus ATCC 29213 (0.03 to 0.12 μg/ml), Enterococcus faecalis ATCC 29212 (0.03 to 0.12 μg/ml), and Streptococcus pneumoniae ATCC 49619 (0.004 to 0.015 μg/ml).

  13. Statistical method for quality control in presence of measurement errors; Methodes statistiques pour le controle de qualite en presence d`erreurs de mesure

    Energy Technology Data Exchange (ETDEWEB)

    Lauer-Peccoud, M.R

    1998-12-31

    In a quality inspection of a set of items where the measurements of values of a quality characteristic of the item are contaminated by random errors, one can take wrong decisions which are damageable to the quality. So of is important to control the risks in such a way that a final quality level is insured. We consider that an item is defective or not if the value G of its quality characteristic is larger or smaller than a given level g. We assume that, due to the lack of precision of the measurement instrument, the measurement M of this characteristic is expressed by {integral} (G) + {xi} where f is an increasing function such that the value {integral} (g{sub 0}) is known and {xi} is a random error with mean zero and given variance. First we study the problem of the determination of a critical measure m such that a specified quality target is reached after the classification of a lot of items where each item is accepted or rejected depending on whether its measurement is smaller or greater than m. Then we analyse the problem of testing the global quality of a lot from the measurements for a example of items taken from the lot. For these two kinds of problems and for different quality targets, we propose solutions emphasizing on the case where the function {integral} is linear and the error {xi} and the variable G are Gaussian. Simulation results allow to appreciate the efficiency of the different considered control procedures and their robustness with respect to deviations from the assumptions used in the theoretical derivations. (author) 42 refs.

  14. Surface photovoltage method for the quality control of silicon epitaxial layers on sapphire

    Energy Technology Data Exchange (ETDEWEB)

    Yaremchuk, A. F.; Starkov, A. V.; Zaikin, A. V., E-mail: lynch0000@gmail.com [National Rsearch University MIET (Russian Federation); Alekseev, A. V. [ZAO “Telekom-STV” (Russian Federation); Sokolov, E. M. [ZAO “Epiel” (Russian Federation)

    2014-12-15

    The surface photovoltage method is used to study “silicon-on-sapphire” epitaxial layers with a thickness of 0.3–0.6 μm, which are used to fabricate p-channel MOS (metal—oxide-semiconductor) transistors with improved radiation hardness. It is shown that the manner in which the photoconductivity of the epitaxial layer decays after the end of a light pulse generated by a light-emitting diode (wavelength ∼400 nm) strongly depends on the density of structural defects in the bulk of the structure. This enables control over how a “silicon-on-sapphire” structure is formed to provide the manufacturing of MOS structures with optimal operating characteristics.

  15. Plastic Injection Quality Controlling Using the Lean Six Sigma and FMEA Method

    Science.gov (United States)

    Mansur, A.; Mu'alim; Sunaryo

    2016-01-01

    PT. Yogya Presisi Teknikatama Industri (PT. YPTI) is a mold, precision part, and plastic injection maker company. One of the obstacles faced by the company is the high level of nonconformity on its production results. The waste on production process can be identified and classified into four types, i.e.: a). during the process of injection molding machines, b). finishing and cutting processes, c). quality control process and d). the packaging process. The objectives of this research are minimizing the defective goods and reducing the waste using Lean Six Sigma and FMEA approaches, especially for Bush product. From the analysis result, defective types on Bush product can be classified into bubble, speckle, short shoot, sunken, sink mark, over-cut, flashing, and discolor. Based on the attributes data on Bush product, the DPMO score is 988.42 or the sigma level is 4.6, While the DPMO score on the variable data on each dimension i.e.: a). Slit width on the bottom side has DPMO score of 30119 (sigma level 3.37), b). Diameter of the circle on the top side has DPMO score of 392294 (sigma level 1.77), c). Product thickness on the top side has DPMO score of 70474 (sigma level 2.97), d). Product height has DPMO score of 82107 (sigma level 2.89), product thickness on the bottom side has DPMO score of 24448 (sigma level 3.47), and f). Diameter of the circle on the bottom side has DPMO score of 24448 (sigma level 3.47). The highest RPN score on the dominant types of product defects which needs improvement are the defective goods of bubble type has RPN score of 729, flashing and the molten material out on the heating channel has RPN score of 384, over cutting has RPN score of 324 and sink mark has RPN score of 270. The recommendations for improvement that can be given from this research are making checklist for maintenance and production monitoring, enhancing work supervision and inspection, as well as improving the environment and work stations.

  16. Safe introduction and quality control of new methods in coronary surgery.

    Science.gov (United States)

    Bergsland, Jacob

    2011-12-01

    The first part of the paper analyses off pump coronary bypass surgery (OPCAB), which is compared with traditional on-pump procedures (ONCAB). Furthermore ,the paper evaluates the use of a new automatic device for performance of the proximal anastomosis and finally the effect of intracoronary shunt on myocardial ischemia during OPCAB. The main goal of the paper is to demonstrate the importance of careful clinical studies during introduction of the new techniques in cardiac surgery. Statistical analysis was performed on a large clinical database from Buffalo, NY, USA comparing OPCAB and ONCAB. Subsequently, a sequential controlled clinical study compared patients operated with a new automatic connector device to patients operated with classic suture technique. Finally a randomized study was performed to evaluate the effect of the use of an intracoronary shunt during construction of distal anastomosis. The studies from Buffalo demonstrated reduced complications rates in high risk patients when OPCAB techniques were used. The use of connector devices in saphenous venous anastomosis was clearly inferior to standard technique. Intracoronary shunt was found to be beneficial by preventing ischemia. Numerous studies have studied the results of OPCAB vs ONCAB and although results are variable it seems that OPCAB is advantageous in high risk patients, while in low risk patients there are much less if any benefit. The results of the studies of connector devices caused the product to be taken off the market. The value of shunt in OPCAB was clearly demonstrated by the randomized studies. The investigations presented in this paper clearly demonstrates the importance of well-designed studies when new surgical methods are introduced. In the present period of rapid technological development, carefully controlled, un-biased clinical trials are crucial to preserve patient safety and avoid unjustified societal cost.

  17. A Validated High-Throughput Fluorometric Method for Determination of Omeprazole in Quality Control Laboratory via Charge Transfer Sensitized Fluorescence.

    Science.gov (United States)

    Mahmoud, Ashraf M; Ahmed, Sameh A

    2016-03-01

    A high-throughput 96-microwell plate fluorometric method was developed and validated to determine omeprazole (OMZ) in its dosage forms. The method was based on the charge-transfer (CT) sensitized fluorescence reaction of OMZ with 2, 3-dichloro-5, 6-dicyano-1, 4-benzoquinone (DDQ). This fluorescence reaction provided a new approach for simple, sensitive and selective determinations of OMZ in pharmaceutical preparations. In the present method, the fluorescence reaction was carried out in 96-microwell plates as reaction vessels in order to increase the automation of the methodology and the efficiency of its use in quality control laboratories. All factors affecting the fluorescence reaction were carefully studied and the conditions were optimized. The stoichiometry of the fluorescence reaction between OMZ and DDQ was determined and the reaction mechanism was suggested. Under the optimum conditions, the linear range was 100-6000 ng/ml with the lowest LOD of 33 ng/ml. Analytical performance of the proposed assay, in terms of accuracy and precision, was statistically validated and the results were satisfactory; RSD was <2.6 % and the accuracy was 98.6-101.6 %. The method was successfully applied to the analysis of OMZ in its dosage forms; the recovery values were 98.26-99.60 ± 0.95-2.22 %. The developed methodology may provide a safer, automated and economic tool for the analysis of OMZ in quality control laboratories.

  18. [A method for auditing medical records quality: audit of 467 medical records within the framework of the medical information systems project quality control].

    Science.gov (United States)

    Boulay, F; Chevallier, T; Gendreike, Y; Mailland, V; Joliot, Y; Sambuc, R

    1998-03-01

    Future hospital accreditation could take into account the quality of medical files. The objectives of this study is to test a method for auditing and evaluating the quality of the handing of medical files. We conducted a retrospective regional audit based on the frame of reference the National Agency for Medical Development and Evaluation, by using a sample of cases, stratified by establishment. In our region, the global budgets of 47 public and private hospitals participating in the public hospital service, are adjusted while keeping in mind the medicalised activity data (PMSI). This audit was proposed to the doctors of the Department of Medical Information on the occasion of the regulatory PMSI quality control. A total of 467 questionnaires were given by 39 of the 47 sollicited hospitals (83%). The methodological aspects (questionnaire, cooperative approach...) are discussed. The make-up of medical files can alos be improved by raising the percentage of the presence of important data or documents such as the reason for admission (74.1%), the surgery report (83.2%), and the hospitalisation report (66.6%). A system for classifying the paraclinical results is shared and systematic throughout the service or hospital in only 73.2% of cases. The quality of the handing of medical files seems problematic in our hospitals and actions for improving the quality should be undertaken as a priority.

  19. SAQC: SNP Array Quality Control

    Directory of Open Access Journals (Sweden)

    Li Ling-Hui

    2011-04-01

    Full Text Available Abstract Background Genome-wide single-nucleotide polymorphism (SNP arrays containing hundreds of thousands of SNPs from the human genome have proven useful for studying important human genome questions. Data quality of SNP arrays plays a key role in the accuracy and precision of downstream data analyses. However, good indices for assessing data quality of SNP arrays have not yet been developed. Results We developed new quality indices to measure the quality of SNP arrays and/or DNA samples and investigated their statistical properties. The indices quantify a departure of estimated individual-level allele frequencies (AFs from expected frequencies via standardized distances. The proposed quality indices followed lognormal distributions in several large genomic studies that we empirically evaluated. AF reference data and quality index reference data for different SNP array platforms were established based on samples from various reference populations. Furthermore, a confidence interval method based on the underlying empirical distributions of quality indices was developed to identify poor-quality SNP arrays and/or DNA samples. Analyses of authentic biological data and simulated data show that this new method is sensitive and specific for the detection of poor-quality SNP arrays and/or DNA samples. Conclusions This study introduces new quality indices, establishes references for AFs and quality indices, and develops a detection method for poor-quality SNP arrays and/or DNA samples. We have developed a new computer program that utilizes these methods called SNP Array Quality Control (SAQC. SAQC software is written in R and R-GUI and was developed as a user-friendly tool for the visualization and evaluation of data quality of genome-wide SNP arrays. The program is available online (http://www.stat.sinica.edu.tw/hsinchou/genetics/quality/SAQC.htm.

  20. In-house validation and quality control of real-time PCR methods for GMO detection: a practical approach.

    Science.gov (United States)

    Ciabatti, I; Froiio, A; Gatto, F; Amaddeo, D; Marchesi, U

    2006-01-01

    GMO detection and quantification methods in the EU are mainly based on real-time PCR. The analytical methods in use must be validated, first on an intra-laboratory scale and through a collaborative trial thereafter. Since a consensual protocol for intra-laboratory validation of real-time PCR methods is lacking, we provide a practical approach for the in-house validation of quantitative real-time PCR methods, establishing acceptability criteria and quality controls for PCR runs. Parameters such as limit of detection, limit of quantification, precision, trueness, linear dynamic range, PCR efficiency, robustness and specificity are considered. The protocol is sufficiently detailed to be directly applicable, increases the reliability of results and their harmonization among different laboratories, and represents a necessary preliminary step before proceeding to a time-consuming and costly full validation study.

  1. Biomonitoring of boron: Development and characterization of a simple, reliable and quality controlled biomonitoring method.

    Science.gov (United States)

    Michalke, Bernhard

    2017-03-01

    Boron exposure is of interest and concern from an occupational point of view. Usual daily boron intake is related to boron blood plasma concentration boron biomonitoring, typically in urine, thus is mandatory for occupational health control institutions. This paper reports on the development of a simple, fast and reliable boron determination procedure based on inductively coupled plasma - optical emission spectrometry (ICP-OES). Major aims for this method were simplicity in sample preparation, low risk for artifacts and interferences, high precision and accuracy, possibly low costs, including lower costs for element selective detection, short total analysis time and suitability for occupational health laboratories. Precision data (serial or day-to-day) from urine and doped urine were very good: <1.5 or <2%. Accuracy was calculated from analysis of a certified reference material (ERM-CD 281), as 99% or according to recoveries of doped concentrations ranging from 102 to 109% recovery. For cross-checking ICP-OES determinations, samples were analyzed also by quadrupole ICP-qMS and by sectorfield ICP-sf-MS at low and medium resolution. Both systems confirmed ICP-OES measurements when using (11)B for quantification. Determinations based on (10)B however showed some bias, except with ICP-sf-MS at medium resolution. The observed elevated signals are discussed with respect to the known Ne(++) interference (as an impurity in Ar), which is not separated in low resolving quadrupole ICP-MS systems or ICP-sf-MS at low resolution. Copyright © 2016 Elsevier GmbH. All rights reserved.

  2. A Simplified but Effective Method for the Quality Control of Medicinal Plants by Planar Chromatography

    OpenAIRE

    Eloff, JN; Ntloedibe, DT; van Brummelen, R

    2011-01-01

    Three of the factors limiting the rational use of herbal medicine are uncertainty on effectivity, uncertainty on safety and variation in quality of the product. Because many herbal medicines have been used over centuries by indigenous peoples, the safety and effectivity is frequently not such a big concern. With more people collecting and distributing herbal medicine, the offered product is however, frequently not what the label indicates either through a genuine mistake, but also through fra...

  3. Sensory and rapid instrumental methods as a combined tool for quality control of cooked ham

    OpenAIRE

    Barbieri, Sara; Soglia, Francesca; Palagano, Rosa; Tesini, Federica; Bendini, Alessandra; Petracci, Massimiliano; Cavani, Claudio; Gallina Toschi, Tullia

    2016-01-01

    In this preliminary investigation, different commercial categories of Italian cooked pork hams have been characterized using an integrated approach based on both sensory and fast instrumental measurements. For these purposes, Italian products belonging to different categories (cooked ham, ?selected? cooked ham and ?high quality? cooked ham) were evaluated by sensory descriptive analysis and by the application of rapid tools such as image analysis by an ?electronic eye? and texture analyzer. T...

  4. Quality Management, Quality Assurance and Quality Control in Blood Establishments

    OpenAIRE

    Bolbate, N

    2008-01-01

    Quality terms and the roots of the matter are analyzed according to European Committee’s recommendations. Essence of process and product quality control as well as essence of quality assurance is described. Quality system’s structure including quality control, quality assurance and management is justified in the article.

  5. Quality assurance and statistical control

    DEFF Research Database (Denmark)

    Heydorn, K.

    1991-01-01

    In scientific research laboratories it is rarely possible to use quality assurance schemes, developed for large-scale analysis. Instead methods have been developed to control the quality of modest numbers of analytical results by relying on statistical control: Analysis of precision serves...... serves to detect analytical bias by comparing results obtained by two different analytical methods, each relying on a different detection principle and therefore exhibiting different influence from matrix elements; only 5-10 sets of results are required to establish whether a regression line passes...

  6. AUTOMATION OF QUALITY CONTROL OF MILK HOMOGENIZATION BY ULTRASONIC SPECTROSCOPY METHODS

    OpenAIRE

    V. K. Bityukov; A. A. Khvostov; D. I. Rebrikov; V. E. Merzlikin

    2015-01-01

    The paper deals with the possibility of determining homogenization degree of milk and dairy products using ultrasonic vibrations absorption spectra. Advantages of this method application in automated manufacturing systems were examined. Theoretical background of the method, as well as the possibility of determining the distribution of the fat globules in milk, depending on their sizes were substantiated. We derived mathematical equations, showing the relationship between the homogenization de...

  7. COMPARISON OF GEOCODING METHODS USED IN CASE-CONTROL STUDY OF AIR QUALITY AND BIRTH DEFECTS

    Science.gov (United States)

    Introduction: Accurate geocoding of maternal residence is critical to the success of an ongoing case-control study of exposure to five criteria air pollutants and the risk of selected birth defects in seven Texas counties between 1997 and 2000. The geocoded maternal residence a...

  8. The efficacy of a continuous quality improvement (CQI) method in a radiological department: comparison with non-CQI control material

    Energy Technology Data Exchange (ETDEWEB)

    Laurila, J. [Oulu Univ. Central Hospital (Finland). Dept. of Radiology; Standertskjoeld-Nordenstam, C.G. [Helsinki Univ. Central Hospital (Finland). Dept. of Radiology; Suramo, I. [Oulu Univ. Central Hospital (Finland). Dept. of Radiology; Tolppanen, E.M. [Helsinki Univ. (Finland). Dept. of Public Health; Tervonen, O. [Oulu Univ. Central Hospital (Finland). Dept. of Radiology; Korhola, O. [Helsinki Univ. Central Hospital (Finland). Dept. of Radiology; Brommels, M. [Helsinki Univ. (Finland). Dept. of Public Health

    2000-01-01

    To study the efficacy of continuous quality improvement (CQI) compared to ordinary management in an on-duty radiology department. Because of complaints regarding delivery of on-duty radiological services, an improvement was initiated simultaneously at two hospitals, at the HUCH (Helsinki University Central Hospital) utilising the CQI-method, and at the OUH (Oulu University Hospital) with a traditional management process. For the CQI project, a team was formed to evaluate the process with flow-charts, cause and effect diagrams, Pareto analysis and control charts. Interventions to improve the process were based on the results of these analyses. The team at the HUCH implemented the following changes: A radiologist was added to the evening shift between 15:00 - 22:00 and a radiographer was moved from the morning shift to 15:00 - 22:00. A clear improvement was achieved in the turn-around time, but in the follow-up some of the gains were lost. Only minimal changes were achieved at the OUH, where the intervention was based on traditional management processes. CQI was an effective method for improving the quality of performance of a radiology department compared with ordinary management methods, but some of this improvement may be subsequently lost without a continuous measurement system.

  9. Birth Control Methods

    Science.gov (United States)

    ... Home A-Z Health Topics Birth control methods Birth control methods > A-Z Health Topics Birth control methods ... To receive Publications email updates Enter email Submit Birth control methods Birth control (contraception) is any method, medicine, ...

  10. Validation of analytical methods used in the quality control of biotechnology products

    Directory of Open Access Journals (Sweden)

    I. Rosales

    2012-06-01

    Full Text Available Las biotecnologías modernas, no solo se han ocupado del diseño de ingeniosos procesos productivos para la obtención de metabolitos de interés, o de la novedosa manipulación genética de microorganismos como la scherichia coli; si no que ha establecido una serie de normas para el control de la calidad de los productos biotecnológicos. Algunas de estas normas están encaminadas a garantizar la reproducibilidad y especificidad de las técnicas analíticas empleadas en el control de calidad, a través de la validación.

  11. Quality control of roll-to-roll processed polymer solar modules by complementary imaging methods

    DEFF Research Database (Denmark)

    Rösch, R.; Krebs, Frederik C; Tanenbaum, D.M.

    2012-01-01

    We applied complementary imaging methods to investigate processing failures of roll-to-roll solution processed polymer solar modules based on polymer:fullerene bulk heterojunctions. For investigation of processing deficiencies in solar modules we employed dark lock-in thermography (DLIT), electro......We applied complementary imaging methods to investigate processing failures of roll-to-roll solution processed polymer solar modules based on polymer:fullerene bulk heterojunctions. For investigation of processing deficiencies in solar modules we employed dark lock-in thermography (DLIT...

  12. VGI QUALITY CONTROL

    Directory of Open Access Journals (Sweden)

    C. C. Fonte

    2015-08-01

    Full Text Available This paper presents a framework for considering quality control of volunteered geographic information (VGI. Different issues need to be considered during the conception, acquisition and post-acquisition phases of VGI creation. This includes items such as collecting metadata on the volunteer, providing suitable training, giving corrective feedback during the mapping process and use of control data, among others. Two examples of VGI data collection are then considered with respect to this quality control framework, i.e. VGI data collection by National Mapping Agencies and by the most recent Geo-Wiki tool, a game called Cropland Capture. Although good practices are beginning to emerge, there is still the need for the development and sharing of best practice, especially if VGI is to be integrated with authoritative map products or used for calibration and/or validation of land cover in the future.

  13. Instantaneous phasor method for obtaining instantaneous balanced fundamental components for power quality control and continuous diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Hsu, J.S.

    1997-07-01

    This paper introduces an instantaneous phasor method that considers three phases simultaneously. This method produces the instantaneous fundamental balanced components of the polluted voltages or currents. A figure shows three-phase voltages that contain 5% of fundamental magnitude for each order of the 3rd, 5th, 7th, 9th and the 11th harmonics, respectively. Additionally, the voltages have 5% unbalance for all voltage components. A 10% fundamental-frequency zero-sequence component, as well as a 10% fundamental-frequency negative-sequence component are also added to the phase voltages. Furthermore, certain high-frequency pulses arbitrarily given at 5% of a 35th order to represent a possible carrier frequency of power electronic circuits are also included.

  14. Growth methods for controlled large-area fabrication of high-quality graphene analogs

    Energy Technology Data Exchange (ETDEWEB)

    Najmaei, Sina; Liu, Zheng; Ajayan, Pulickel M.; Lou, Jun

    2017-02-28

    In some embodiments, the present disclosure pertains to methods of growing chalcogen-linked metallic films on a surface in a chamber. In some embodiments, the method comprises placing a metal source and a chalcogen source in the chamber, and gradually heating the chamber, where the heating leads to the chemical vapor deposition of the chalcogen source and the metal source onto the surface, and facilitates the growth of the chalcogen-linked metallic film from the chalcogen source and the metal source on the surface. In some embodiments, the chalcogen source comprises sulfur, and the metal source comprises molybdenum trioxide. In some embodiments, the growth of the chalcogen-linked metallic film occurs by formation of nucleation sites on the surface, where the nucleation sites merge to form the chalcogen-linked metallic film. In some embodiments, the formed chalcogen-linked metallic film includes MoS.sub.2.

  15. [Quality control in microbiology (author's transl)].

    Science.gov (United States)

    Lamanna, A

    1977-01-01

    The microbiology quality control importance is emphasized and some particular problems that quality control presents in microbiology are also indicated. There are two types of microbiology quality control as well as for hematology and chemical chemistry: collective quality control, between more laboratories, and individual quality control, in the sphere of each laboratory. A.M.O.I. (Associazione Microbiologi Ospedalieri Italiani) and I.S.V.T. (Istituto Sieroterapico Vaccinogeno Toscano) Sclavo collaborating, have organized a collective quality control between laboratories of different hospitals during the year 1974 and 1975. The results of this control are reported. Although preliminary, they indicate practical importance of microbiology control. During 1975, in fact, the pathogens isolated have been in high percentage than 1976. At last, the future quality control's program aiming at methods's standardization and technical, methodical instructions is indicated.

  16. A systematic survey of the methods literature on the reporting quality and optimal methods of handling participants with missing outcome data for continuous outcomes in randomized controlled trials.

    Science.gov (United States)

    Zhang, Yuqing; Alyass, Akram; Vanniyasingam, Thuva; Sadeghirad, Behnam; Flórez, Iván D; Pichika, Sathish Chandra; Kennedy, Sean Alexander; Abdulkarimova, Ulviya; Zhang, Yuan; Iljon, Tzvia; Morgano, Gian Paolo; Colunga Lozano, Luis E; Aloweni, Fazila Abu Bakar; Lopes, Luciane C; Yepes-Nuñez, Juan José; Fei, Yutong; Wang, Li; Kahale, Lara A; Meyre, David; Akl, Elie A; Thabane, Lehana; Guyatt, Gordon H

    2017-08-01

    To conduct (1) a systematic survey of the reporting quality of simulation studies dealing with how to handle missing participant data (MPD) in randomized control trials and (2) summarize the findings of these studies. We included simulation studies comparing statistical methods dealing with continuous MPD in randomized controlled trials addressing bias, precision, coverage, accuracy, power, type-I error, and overall ranking. For the reporting of simulation studies, we adapted previously developed criteria for reporting quality and applied them to eligible studies. Of 16,446 identified citations, the 60 eligible generally had important limitations in reporting, particularly in reporting simulation procedures. Of the 60 studies, 47 addressed ignorable and 32 addressed nonignorable data. For ignorable missing data, mixed model was most frequently the best on overall ranking (9 times best, 34.6% of times tested) and bias (10, 55.6%). Multiple imputation was also performed well. For nonignorable data, mixed model was most frequently the best on overall ranking (7, 46.7%) and bias (8, 57.1%). Mixed model performance varied on other criteria. Last observation carried forward (LOCF) was very seldom the best performing, and for nonignorable MPD frequently the worst. Simulation studies addressing methods to deal with MPD suffered from serious limitations. The mixed model approach was superior to other methods in terms of overall performance and bias. LOCF performed worst. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Utilization of Digital Image Processing In Process of Quality Control of The Primary Packaging of Drug Using Color Normalization Method

    Science.gov (United States)

    Erwanto, Danang; Arttini Dwi Prasetyowati, Sri; Nuryanto Budi Susila, Eka

    2017-04-01

    In the process of quality control, accuracy is required so that the improper drug packaging is not included into the next production process. The automatic inspection system using digital image processing can be applied to replace the manual inspection system done by humans. The image captured from the vision sensor is RGB image which is then converted into grayscale. The process of converting RGB image into grayscale image is performed using the color normalization method to spread the data of RGB colors at each pixel. From the software of image processing using the color normalization method that have been created, it shows grayscale images on the drug object which have degrees of gray higher than the grayscale image section of the background when the degree of the R, G or B color of drug is higher than the degree of the R, G, B color on the background of packaging. The determination of threshold value indicates that the binary image of the drug is white and a binary image of the background of drug packaging is black.

  18. An innovative method for quality control of conjugated Haemophilus influenzae vaccines: A short review of two-dimensional nanoparticle electrophoresis.

    Science.gov (United States)

    Tietz, Dietmar

    2009-12-25

    This article provides an overview of a 2D agarose electrophoretic procedure for the characterization of semi-synthetic Haemophilus influenzae type b meningitis vaccines that were prepared for the immunization of small children. The analysis of such vaccines has been particularly challenging because the vaccine particles (i) are highly negatively charged, (ii) are as large as or even larger than intact viruses, and (iii) have a continuous (polydisperse) size distribution because of randomizing steps in the vaccine production (sonification and crosslinking). As a result of these characteristics, 1D electrophoresis of the vaccines produced smears without discernable peaks, but with a second dimension of separation a characteristic vaccine fingerprint was obtained. Whereas O'Farrell gels can accomplish a 2D separation according to size and charge for samples with protein-sized particles, nondenaturing 2D agarose electrophoresis achieves a similar result for much larger virus-sized particles. The separation principle, however, is different. Even though the 2D electrophoretic method was developed from 1983 to 1995, it remains a promising tool for vaccine quality control and for predicting vaccine effectiveness. Modern technology makes the analysis significantly more practical and affordable than it was more than 10 years ago, and the method is applicable to a variety of conjugated vaccines and complex mixtures of virus-sized particles.

  19. Assay method for quality control and stability studies of a new antimalarial agent (CDRI 99/411)$

    Institute of Scientific and Technical Information of China (English)

    Kiran Khandelwal; Shakti Deep Pachauri; Sofia Zaidi; Pankaj Dwivedi; Ashok Kumar Sharma; Chandan Singh; Anil Kumar Dwivedi

    2013-01-01

    CDRI compound no. 99/411 is a potent 1,2,4-trioxane antimalarial candidate drug under development at our Institute. An HPLC method for determination of CDRI 99/411 with its starting material and intermediates has been developed and validated for in process quality control and stability studies. The analytical performance parameters such as linearity, precision, accuracy, specificity, limit of detection (LOD) and lower limit of quantification (LLOQ) were determined according to International Conference on Harmonization ICH Q2(R1) guidelines. HPLC separation was achieved on a RP-select B Lichrospheres column (250 mm  4 mm, 5μm, Merck) using water containing 0.1%glacial acetic acid and acetonitrile as the mobile phase in a gradient elution. The eluents were monitored by a photo diode array detector at 245 and 275 nm. Based on signal to noise ratio of 3 and 10 the LOD of CDRI 99/411 was 0.55 mg/mL, while the LLOQ was 1.05 mg/mL. The calibration curves were linear in the range of 1.05-68 mg/mL. Precision of the method was determined by inter- and intra-assay variations within the acceptable range.

  20. MAIN PROBLEMS OF CONTROLLING OF THE QUALITY

    Directory of Open Access Journals (Sweden)

    Orlov A. I.

    2015-09-01

    Full Text Available Controlling of statistical methods to ensure product quality is the special case of controlling organizational and economic methods of management. Today, controlling in the practice of management of Russian companies is understood as "the system of information-analytical and methodological support to achieve their goals." The controller is developing a decision-making rules, the head takes decisions on the basis of these rules. We proved the concept of "controlling of methods". Innovation in management is based, in particular, on the use of new adequate organizational-economic (as well as economicmathematical and statistical methods. Controlling in this area - is the development and application procedures of compliance management used and newly developed (implemented organizationaleconomic methods for the task. Thus, the methodology for controlling is of great practical value in any field in which the actions (operations must be carried out in accordance with certain rules (regulations, standards, guidelines, as in any such area in which we need to use development and application procedures of compliance management used and the newly established (implemented rules for solution of tasks assigned to the organization. In this article, we select a area of controlling as controlling quality, and we discuss its main issues. This is about controlling of organizational-economic methods to ensure product quality, especially about the statistical methods based on probability theory and mathematical statistics. We consider the analysis and synthesis of plans of statistical quality control, optimization options plans of statistical control, truncated plans. Are discussed the differences control plans provider and the consumer, the allocation of units formless (liquid, gas products, the selection of a random sample of the statistical quality control of products, lower estimate of the required sample size. It is established, that is not always necessary

  1. Pilot studies for the North American Soil Geochemical Landscapes Project - Site selection, sampling protocols, analytical methods, and quality control protocols

    Science.gov (United States)

    Smith, D.B.; Woodruff, L.G.; O'Leary, R. M.; Cannon, W.F.; Garrett, R.G.; Kilburn, J.E.; Goldhaber, M.B.

    2009-01-01

    In 2004, the US Geological Survey (USGS) and the Geological Survey of Canada sampled and chemically analyzed soils along two transects across Canada and the USA in preparation for a planned soil geochemical survey of North America. This effort was a pilot study to test and refine sampling protocols, analytical methods, quality control protocols, and field logistics for the continental survey. A total of 220 sample sites were selected at approximately 40-km intervals along the two transects. The ideal sampling protocol at each site called for a sample from a depth of 0-5 cm and a composite of each of the O, A, and C horizons. The acid digestion. A separate sample of 0-5-cm material was collected at each site for determination of organic compounds. A subset of 73 of these samples was analyzed for a suite of 19 organochlorine pesticides by gas chromatography. Only three of these samples had detectable pesticide concentrations. A separate sample of A-horizon soil was collected for microbial characterization by phospholipid fatty acid analysis (PLFA), soil enzyme assays, and determination of selected human and agricultural pathogens. Collection, preservation and analysis of samples for both organic compounds and microbial characterization add a great degree of complication to the sampling and preservation protocols and a significant increase to the cost for a continental-scale survey. Both these issues must be considered carefully prior to adopting these parameters as part of the soil geochemical survey of North America.

  2. [Quality control in parasitology].

    Science.gov (United States)

    Vasallo Matilla, F

    2001-01-01

    Between 1990 and 1996 we coordinated a Quality Control (QC) Program in Parasitology directed to Public Health Institutions in Spain. Periodically, parasited specimens, mainly feces or blood, were sent to Microbiology Laboratories for identification. Each QC was accompanied by a short clinic and epidemiological information in order to help in the diagnostic approach. After the answers to the QC were received a bulletin that included the solution to the QC, comments on the several answers received and a chapter with parasitological themes related with the QC, was sent to each participating Laboratory. The bulletin was accompanied by a card that included a photograph and a short description of the organism object of the QC.

  3. Quality-Control Analytical Methods: Microbial-Testing Aspects of USP Chapter 797 for Compounded Sterile Preparations.

    Science.gov (United States)

    Kupiec, Thomas C

    2005-01-01

    The standards set forth by the United States Pharmacopeia (USP) Chapter 797 have now been in effect since January 1 or 2004. As the first practice standards of sterile pharmacy compounding in US history, they have "attracted both respect and criticism" because they have also been cited as a practice expectation by the Joint Commission on Accreditation of Healthcare Organizations. USP 797 expands the scope of facilities governed by the regulatinos and defines the practices covered, emphasizing the importance of environmental quality and control, verification of accuracy and sterility, training and evaluation, quality control after preparations leave the pharmacy, patient monitoring and adverse events reporting. The purpose of this article is to help the reader understand the criteria set forth by USP Chapter 797 regarding finished-product testing, including criteria for the microbial-testing aspects of sterility testing (USP Chapter 71) and endotoxin (pyrogen) testing (USP Chapter 85).

  4. Quality control of tuirejieduling granules using high-performance liquid chromatography fingerprint method and simultaneous determination of four main active ingredients

    Directory of Open Access Journals (Sweden)

    Aixia Yang

    2013-01-01

    Full Text Available Background: The Tuirejieduling granule is a compound preparation made from four kinds of Chinese medicines. It is effective for anti-inflammation, antivirus, defervescence and anti-bacterium; however, its quality control standards have remained unknown. Objective: To establish a simple and accurate fingerprint method for quality control of the Tuirejieduling granule. Materials and Methods: The methanol extract of the Tuirejieduling granule was used for the fingerprint analysis and the four selected active ingredients (epigoitrin, phillyrin, saikosaponin A and glycyrrhetinic acid in the extract were determined. The fingerprint method was performed on an Amethyst C18-P chromatography column by gradient elution with acetonitrile and aqueous phase (containing 0.5% H 3 PO 4 (v/v, pH 3.0. Results: Under the optimal chromatographic condition, twenty peaks were chosen as fingerprint peaks of the Tuirejieduling granules extractions. The similarities of 10 batches of Tuirejieduling granule was more than 0.99. This indicates that the different batches of Tuirejieduling granules were under the consistent quality control. Good linear behaviors over the investigated concentration ranges were obtained with the values of R2 higher than 0.99 for four studied active ingredients. The recoveries for spiked samples were in the range of 96.2-105.5%. The developed method was successfully applied to determine the contents of active constituents in different batches of Tuirejieduling granule. Conclusion: The HPLC fingerprint was proved to be a reliable method for the quality control of Tuirejieduling granule.

  5. Information System Quality Assessment Methods

    OpenAIRE

    Korn, Alexandra

    2014-01-01

    This thesis explores challenging topic of information system quality assessment and mainly process assessment. In this work the term Information System Quality is defined as well as different approaches in a quality definition for different domains of information systems are outlined. Main methods of process assessment are overviewed and their relationships are described. Process assessment methods are divided into two categories: ISO standards and best practices. The main objective of this w...

  6. Information System Quality Assessment Methods

    OpenAIRE

    2014-01-01

    This thesis explores challenging topic of information system quality assessment and mainly process assessment. In this work the term Information System Quality is defined as well as different approaches in a quality definition for different domains of information systems are outlined. Main methods of process assessment are overviewed and their relationships are described. Process assessment methods are divided into two categories: ISO standards and best practices. The main objective of this w...

  7. Posttranslational modification and quality control.

    Science.gov (United States)

    Wang, Xuejun; Pattison, J Scott; Su, Huabo

    2013-01-18

    Protein quality control functions to minimize the level and toxicity of misfolded proteins in the cell. Protein quality control is performed by intricate collaboration among chaperones and target protein degradation. The latter is performed primarily by the ubiquitin-proteasome system and perhaps autophagy. Terminally misfolded proteins that are not timely removed tend to form aggregates. Their clearance requires macroautophagy. Macroautophagy serves in intracellular quality control also by selectively segregating defective organelles (eg, mitochondria) and targeting them for degradation by the lysosome. Inadequate protein quality control is observed in a large subset of failing human hearts with a variety of causes, and its pathogenic role has been experimentally demonstrated. Multiple posttranslational modifications can occur to substrate proteins and protein quality control machineries, promoting or hindering the removal of the misfolded proteins. This article highlights recent advances in posttranslational modification-mediated regulation of intracellular quality control mechanisms and its known involvement in cardiac pathology.

  8. General aviation fuel quality control

    Science.gov (United States)

    Poitz, H.

    1983-01-01

    Quality control measures for aviation gasoline, and some of the differences between quality control on avgas and mogas are discussed. One thing to keep in mind is that with motor gasoline you can always pull off to the side of the road. It's not so easy to do in an airplane. Consequently, there are reasons for having the tight specifications and the tight quality control measures on avgas as compared to motor gasoline.

  9. Quality of regularization methods

    NARCIS (Netherlands)

    Bouwman, J.

    1998-01-01

    The solution of ill-posed problems is non-trivial in the sense that frequently applied methods like least-squares fail. The ill-posedness of the problem is refiected by very small changes in the input data which may result in very large changes in the output data. Hence, some sort of stabilization

  10. Quality of regularization methods

    NARCIS (Netherlands)

    Bouwman, J.

    1998-01-01

    The solution of ill-posed problems is non-trivial in the sense that frequently applied methods like least-squares fail. The ill-posedness of the problem is refiected by very small changes in the input data which may result in very large changes in the output data. Hence, some sort of stabilization o

  11. A Voltage Quality Detection Method

    DEFF Research Database (Denmark)

    Chen, Zhe; Wei, Mu

    2008-01-01

    This paper presents a voltage quality detection method based on a phase-locked loop (PLL) technique. The technique can detect the voltage magnitude and phase angle of each individual phase under both normal and fault power system conditions. The proposed method has the potential to evaluate vario...... power quality disturbances, such as interruptions, sags and imbalances. Simulation studies have been performed. The effectiveness of the proposed method has been demonstrated under the simulated typical power disturbances....

  12. Qualitative and quantitative analyses of Compound Danshen extract based on (1)H NMR method and its application for quality control.

    Science.gov (United States)

    Yan, Kai-Jing; Chu, Yang; Huang, Jian-Hua; Jiang, Miao-Miao; Li, Wei; Wang, Yue-Fei; Huang, Hui-Yong; Qin, Yu-Hui; Ma, Xiao-Hui; Zhou, Shui-Ping; Sun, Henry; Wang, Wei

    2016-11-30

    In this study, a new approach using (1)H NMR spectroscopy combined with chemometrics method was developed for qualitative and quantitative analyses of extracts of Compound Danshen Dripping Pills (CDDP). For the qualitative analysis, some metabolites presented in Compound Danshen extract (CDE, extraction intermediate of CDDP) were detected, including phenolic acids, saponins, saccharides, organic acids and amino acids, by the proposed (1)H NMR method, and metabolites profiles were further analyzed by selected chemometrics algorithms to define the threshold values for product quality evaluation. Moreover, three main phenolic acids (danshensu, salvianolic acid B, and procatechuic aldehyde) in CDE were determined simultaneously, and method validation in terms of linearity, precision, repeatability, accuracy, and stability of the dissolved target compounds in solution was performed. The average recoveries varied between 84.20% and 110.75% while the RSDs were below 6.34% for the three phenolic acids. This (1)H NMR method offers an integral view of the extract composition, allows the qualitative and quantitative analysis of CDDP, and has the potential to be a supplementary tool to UPLC/HPLC for quality assessment of Chinese herbal medicines.

  13. Evaluation of thin-layer chromatography methods for quality control of commercial products containing Aesculus hippocastanum, Turnera diffusa, Matricaria recutita, Passiflora incarnata, and Tilia occidentalis.

    Science.gov (United States)

    Ramírez-Durón, Rosalba; Ceniceros-Almaguer, Lucía; Salazar-Aranda, Ricardo; Salazar-Cavazos, Ma de la Luz; Waksman de Torres, Noemi

    2007-01-01

    In Mexico, plant-derived products with health claims are sold as herbal dietary supplements, and there are no rules for their legal quality control. Aesculus hippocastanum, Turnera diffusa, Matricaria recutita, Passiflora incarnata, and Tilia occidentalis are some of the major commercial products obtained from plants used in this region. In this paper, we describe the effectiveness of thin-layer chromatography methods to provide for the quality control of several commercial products containing these plants. Standardized extracts were used. Of the 49 commercial products analyzed, only 32.65% matched the chromatographic characteristic of standardized extracts. A significant number of commercial products did not match their label, indicating a problem resulting from the lack of regulation for these products. The proposed methods are simple, sensitive, and specific and can be used for routine quality control of raw herbals and formulations of the tested plants. The results obtained show the need to develop simple and reliable analytical methods that can be performed in any laboratory for the purpose of quality control of dietary supplements or commercial herbal products sold in Mexico.

  14. Quality control in gastrointestinal surgery.

    Science.gov (United States)

    Ramírez-Barba, Ector Jaime; Arenas-Moya, Diego; Vázquez-Guerrero, Arturo

    2011-01-01

    We analyzed the Mexican legal framework, identifying the vectors that characterize quality and control in gastrointestinal surgery. Quality is contemplated in the health protection rights determined according to the Mexican Constitution, established in the general health law and included as a specific goal in the actual National Development Plan and Health Sector Plan. Quality control implies planning, verification and application of corrective measures. Mexico has implemented several quality strategies such as certification of hospitals and regulatory agreements by the General Salubrity Council, creation of the National Health Quality Committee, generation of Clinical Practice Guidelines and the Certification of Medical Specialties, among others. Quality control in gastrointestinal surgery must begin at the time of medical education and continue during professional activities of surgeons, encouraging multidisciplinary teamwork, knowledge, abilities, attitudes, values and skills that promote homogeneous, safe and quality health services for the Mexican population.

  15. Analysis of quality control management methods in microbiology laboratory%微生物实验室的质量控制管理方法分析

    Institute of Scientific and Technical Information of China (English)

    美丽坎·阿不都

    2016-01-01

    Microbiological examination plays an important role in disease prevention and control,and the test result accuracy and control of the disease is closely related to such.Microbiology laboratory quality is directly related to the result of microbiological examination.Therefore,for microbiology laboratory take certain measures to quality control and management,for infectious disease research and ensuring the safety of people's lives and has very important significance.In this paper,the author summarizes the significance of the quality control of microbiological laboratory,and analyzes the methods of quality control in the laboratory from 3 aspects,such as management system,indoor quality control and room quality control.%微生物检验在疾病的预防和控制方面具有重要的作用,其检验结果的准确与否与疾病的控制等具有密切的联系。而微生物实验室的质量直接关系到微生物检验的结果,因此,针对微生物实验室采取一定的措施进行质量的控制和管理,对传染性疾病的研究、保证人民的生命安全等都具有十分重要的意义。本文总结了微生物实验室进行质量控制的意义,并从管理体系、室内质量控制、室间质量控制等3方面分析了微生物实验室的质量控制管理方法。

  16. Alternative methods for internal quality control in research laboratories for environmental analysis: a programme for the performance evaluation of equipment, methods and staff

    NARCIS (Netherlands)

    Wieling, J.; Bakkeren, H.A.; Peters, R.J.B.; Gils, W.J.C.G. van; Leer, E.W.B. de; Mulder, S.A.; Burg, P.A. van der; Renesse van Duivenbode, J.A.D. van

    1994-01-01

    In analytical research laboratories, the problem of quality assurance is more difficult to solve than in laboratories devoted exclusively to routine analysis: the former usually have to deal with a much greater variety of samples and may have to develop entirely new methods of analysis. For research

  17. Development of NIRS method for quality control of drug combination artesunate–azithromycin for the treatment of severe malaria

    Science.gov (United States)

    Boyer, Chantal; Gaudin, Karen; Kauss, Tina; Gaubert, Alexandra; Boudis, Abdelhakim; Verschelden, Justine; Franc, Mickaël; Roussille, Julie; Boucher, Jacques; Olliaro, Piero; White, Nicholas J.; Millet, Pascal; Dubost, Jean-Pierre

    2012-01-01

    Near infrared spectroscopy (NIRS) methods were developed for the determination of analytical content of an antimalarial-antibiotic (artesunate and azithromycin) co-formulation in hard gelatin capsule (HGC). The NIRS consists of pre-processing treatment of spectra (raw spectra and first-derivation of two spectral zones), a unique principal component analysis model to ensure the specificity and then two partial least-squares regression models for the determination content of each active pharmaceutical ingredient. The NIRS methods were developed and validated with no reference method, since the manufacturing process of HGC is basically mixed excipients with active pharmaceutical ingredients. The accuracy profiles showed β-expectation tolerance limits within the acceptance limits (±5%). The analytical control approach performed by reversed phase (HPLC) required two different methods involving two different preparation and chromatographic methods. NIRS offers advantages in terms of lower costs of equipment and procedures, time saving, environmentally friendly. PMID:22579599

  18. Development of NIRS method for quality control of drug combination artesunate-azithromycin for the treatment of severe malaria.

    Science.gov (United States)

    Boyer, Chantal; Gaudin, Karen; Kauss, Tina; Gaubert, Alexandra; Boudis, Abdelhakim; Verschelden, Justine; Franc, Mickaël; Roussille, Julie; Boucher, Jacques; Olliaro, Piero; White, Nicholas J; Millet, Pascal; Dubost, Jean-Pierre

    2012-01-01

    Near infrared spectroscopy (NIRS) methods were developed for the determination of analytical content of an antimalarial-antibiotic (artesunate and azithromycin) co-formulation in hard gelatin capsule (HGC). The NIRS consists of pre-processing treatment of spectra (raw spectra and first-derivation of two spectral zones), a unique principal component analysis model to ensure the specificity and then two partial least-squares regression models for the determination content of each active pharmaceutical ingredient. The NIRS methods were developed and validated with no reference method, since the manufacturing process of HGC is basically mixed excipients with active pharmaceutical ingredients. The accuracy profiles showed β-expectation tolerance limits within the acceptance limits (±5%). The analytical control approach performed by reversed phase (HPLC) required two different methods involving two different preparation and chromatographic methods. NIRS offers advantages in terms of lower costs of equipment and procedures, time saving, environmentally friendly.

  19. Frontiers in statistical quality control

    CERN Document Server

    Wilrich, Peter-Theodor

    2004-01-01

    This volume treats the four main categories of Statistical Quality Control: General SQC Methodology, On-line Control including Sampling Inspection and Statistical Process Control, Off-line Control with Data Analysis and Experimental Design, and, fields related to Reliability. Experts with international reputation present their newest contributions.

  20. [Investigation on pattern and methods of quality control for Chinese materia medica based on dao-di herbs and bioassay - bioassay for Coptis chinensis].

    Science.gov (United States)

    Yan, Dan; Xiao, Xiao-he

    2011-05-01

    Establishment of bioassay methods is the technical issues to be faced with in the bioassay of Chinese materia medica. Taking the bioassay of Coptis chinensis Franch. as an example, the establishment process and application of the bioassay methods (including bio-potency and bio-activity fingerprint) were explained from the aspects of methodology, principle of selection, experimental design, method confirmation and data analysis. The common technologies were extracted and formed with the above aspects, so as to provide technical support for constructing pattern and method of the quality control for Chinese materia medica based on the dao-di herbs and bioassay.

  1. Ticks and control methods.

    Science.gov (United States)

    Jongejan, F; Uilenberg, G

    1994-12-01

    Ticks are the most important ectoparasites of livestock in tropical and sub-tropical areas, and are responsible for severe economic losses both through the direct effects of blood sucking and indirectly as vectors of pathogens and toxins. Feeding by large numbers of ticks causes reduction in live weight gain and anaemia among domestic animals, while tick bites also reduce the quality of hides. However, the major losses caused by ticks are due to the ability to transmit protozoan, rickettsial and viral diseases of livestock, which are of great economic importance world-wide. The authors review general aspects of tick biology, the taxonomy, pathogenic effects and vector role of these species, and methods for the control of ticks. The distribution of ticks is continuously changing, as illustrated by the spread of the African tick Amblyomma variegatum in the Caribbean, where a large-scale eradication campaign is now under way.

  2. Preliminary investigation of the possibility for implementation of modified pharmacopoeial HPLC methods for quality control of metronidazole and ciprofloxacin in medicinal products used in veterinary medicine

    Directory of Open Access Journals (Sweden)

    Marjan Piponski

    2015-03-01

    Full Text Available Quality control of veterinary medicine products containing two different frequently used antibiotics metronidazole and ciprofloxacin hydrochloride, was considered and performed, using modified pharmacopoeial HPLC methods. Three different HPLC systems were used: Varian ProStar, Perkin Elmer Series and UPLC Shimadzu Prominence XR. The chromatographic columns used were LiChropher RP Select B 75 mm x 4 mm with 5 μm particles and Discovery C18 100 mm x 4,6 mm with 5 μm particles. Chromatographic methods used for both analytes were compendial, with minor modifications made for experimental purposes. Minor modifications of the pharmacopoeia prescribed chromatographic conditions, in both cases, led to better chromatographic parameters, good resolution and shorter analysis times. Optimized methods can be used for: determination of metronidazole in gel formulation, for its simultaneous quantification with preservatives present in the formulation and even for identification and quantification of its specified impurity, 2-methyl-5-nitroimidazole; determination of ciprofloxacin hydrochloride in film coated tablets and eye drops and identification and quantification of its specified impurities. These slightly modified and optimized pharmacopoeial methods for quality control of metronidazole and ciprofloxacin dosage forms used in veterinary medicine can be successfully applied in laboratories for quality control of veterinary medicines.

  3. 10 CFR 26.137 - Quality assurance and quality control.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Quality assurance and quality control. 26.137 Section 26....137 Quality assurance and quality control. (a) Quality assurance program. Each licensee testing... metabolites. (b) Performance testing and quality control requirements for validity screening tests....

  4. Methods of analysis by the U.S. Geological Survey National Water Quality Laboratory; processing, taxonomy, and quality control of benthic macroinvertebrate samples

    Science.gov (United States)

    Moulton, Stephen R.; Carter, James L.; Grotheer, Scott A.; Cuffney, Thomas F.; Short, Terry M.

    2000-01-01

    Qualitative and quantitative methods to process benthic macroinvertebrate (BMI) samples have been developed and tested by the U.S. Geological Survey?s National Water Quality Laboratory Biological Group. The qualitative processing method is based on visually sorting a sample for up to 2 hours. Sorting focuses on attaining organisms that are likely to result in taxonomic identifications to lower taxonomic levels (for example, Genus or Species). Immature and damaged organisms are also sorted when they are likely to result in unique determinations. The sorted sample remnant is scanned briefly by a second person to determine if obvious taxa were missed. The quantitative processing method is based on a fixed-count approach that targets some minimum count, such as 100 or 300 organisms. Organisms are sorted from randomly selected 5.1- by 5.1-centimeter parts of a gridded subsampling frame. The sorted remnant from each sample is resorted by a second individual for at least 10 percent of the original sort time. A large-rare organism search is performed on the unsorted remnant to sort BMI taxa that were not likely represented in the sorted grids. After either qualitatively or quantitatively sorting the sample, BMIs are identified by using one of three different types of taxonomic assessment. The Standard Taxonomic Assessment is comparable to the U.S. Environmental Protection Agency Rapid Bioassessment Protocol III and typically provides Genus- or Species-level taxonomic resolution. The Rapid Taxonomic Assessment is comparable to the U.S. Environmental Protection Agency Rapid Bioassessment Protocol II and provides Familylevel and higher taxonomic resolution. The Custom Taxonomic Assessment provides Species-level resolution whenever possible for groups identified to higher taxonomic levels by using the Standard Taxonomic Assessment. The consistent use of standardized designations and notes facilitates the interpretation of BMI data within and among water-quality studies

  5. [Quality controls in medical mycology].

    Science.gov (United States)

    Kauffmann-Lacroix, C; Cassaing, S; Bessieres, M-H; Mayet, D; Linas, M-D; Roques, C

    2011-03-01

    The Quality Management System in medical mycology refers to the systematic monitoring with internal and external quality controls: it needs to be organized in the laboratory. ISO 15189 standard is not precise in how to demonstrate the correctness of tests, in terms of frequency and requirements for quality controls QC. That's why the COFRAC, the French Accreditation Committee has published guides to which we should refer. The laboratory has to apply internal Quality Control Programs. They consist of various tests to check the reagents including the culture media. Reference strains have to be provided and preparations of homemade reagents are needed, because few are commercialized. Maintaining the competence of the technical staff through identification of unknown strains is also required. In the fungal serology field, home made antibodies with pooled sera or antigen controls are needed. This monitoring has to follow the recommandations from the Cofrac technical guide LAB GTA 06. For quantitative analysis, the Levey-Jennings chart is a graph with quality control data plotted on to give a visual indication. Some external QC references, besides the national quality control AFSSAPS, are available. Data evaluation, corrective actions in case of out of range results and preventive actions have to be determined in the Quality System documents and presented in the annual management review. Copyright © 2011. Published by Elsevier SAS.

  6. [Quality control of plant extract].

    Science.gov (United States)

    Shao, Yun-dong; Gao, Wen-yuan; Liu, Dan; Jia, Wei; Duan, Hong-Quan; Zhang, Tie-jun

    2003-10-01

    The current situation of plant extract in domestic and international market was analyzed in the paper. The quality control of 20 plant extracts which have reasonably good sales in USA market was compared and analyzed. The analysis of the quality control of six plant extracts indicated that there were two main reasons leading to the varied quality specifications among different suppliers. One reason was that the plant species utilized by different companies were different. The other reason was that the extraction processes were different among different production plants. Comparing with the significant international suppliers of plant extracts, the product quality of Chinese companies were not satisfactory. It was suggested that chromatography and chromatographic fingerprint techniques should be applied to improve the quality control standard of plant extract in our country.

  7. Interlaboratory Study of Quality Control Isolates for a Broth Microdilution Method (Modified CLSI M38-A) for Testing Susceptibilities of Dermatophytes to Antifungals▿

    Science.gov (United States)

    Ghannoum, M. A.; Arthington-Skaggs, B.; Chaturvedi, V.; Espinel-Ingroff, A.; Pfaller, M. A.; Rennie, R.; Rinaldi, M. G.; Walsh, T. J.

    2006-01-01

    The Clinical and Laboratory Standards Institute (CLSI; formerly National Committee for Clinical Laboratory Standards, or NCCLS) M38-A standard for the susceptibility testing of filamentous fungi does not specifically address the testing of dermatophytes. In 2003, a multicenter study investigated the reproducibility of the microdilution method developed at the Center for Medical Mycology, Cleveland, Ohio, for testing the susceptibility of dermatophytes. Data from that study supported the introduction of this method for testing dermatophytes in the future version of the CLSI M38-A standard. In order for the method to be accepted by CLSI, appropriate quality control isolates needed to be identified. To that end, an interlaboratory study, involving the original six laboratories plus two additional sites, was conducted to evaluate potential candidates for quality control isolates. These candidate strains included five Trichophyton rubrum strains known to have elevated MICs to terbinafine and five Trichophyton mentagrophytes strains. Antifungal agents tested included ciclopirox, fluconazole, griseofulvin, itraconazole, posaconazole, terbinafine, and voriconazole. Based on the data generated, two quality control isolates, one T. rubrum isolate and one T. mentagrophytes isolate, were identified and submitted to the American Type Culture Collection (ATCC) for inclusion as reference strains. Ranges encompassing 95.2 to 97.9% of all data points for all seven drugs were established. PMID:17050812

  8. Control by quality: proposition of a typology.

    Science.gov (United States)

    Pujo, P; Pillet, M

    The application of Quality tools and methods in industrial management has always had a fundamental impact on the control of production. It influences the behavior of the actors concerned, while introducing the necessary notions and formalizations, especially for production systems with little or no automation, which constitute a large part of the industrial activity. Several quality approaches are applied in the workshop and are implemented at the level of the control. In this paper, the authors present a typology of the various approaches that have successively influenced control, such as statistical process control, quality assurance, and continuous improvement. First the authors present a parallel between production control and quality organizational structure. They note the duality between control, which is aimed at increasing productivity, and quality, which aims to satisfy the needs of the customer. They also note the hierarchical organizational structure of these two systems of management with, at each level, the notion of a feedback loop. This notion is fundamental to any kind of decision making. The paper is organized around the operational, tactical, and strategic levels, by describing for each level the main methods and tools for control by quality. The overview of these tools and methods starts at the operational level, with the Statistical Process Control, the Taguchi technique, and the "six sigma" approach. On the tactical level, we find a quality system approach, with a documented description of the procedures introduced in the firm. The management system can refer here to Quality Assurance, Total Productive Maintenance, or Management by Total Quality. The formalization through procedures of the rules of decision governing the process control enhances the validity of these rules. This leads to the enhancement of their reliability and to their consolidation. All this counterbalances the human, intrinsically fluctuating, behavior of the control

  9. Using PDCA Method to Control the Quality of Medical Record Link, Strengthen the Process Control Management%运用PDCA法进行病案环节质量控制,加强全程监控管理

    Institute of Scientific and Technical Information of China (English)

    王晨

    2014-01-01

    为了提高病案书写质质量,建立严密的病案质量全程监控管理系统,实行病案质量自我控质、监督控制和终末控制,运用PDCA法做到逐级负责,把监控结果以质量简报的形式反馈到院级网络和所有科室,并同时在院周会上通报。使病案质量重心从终末质量转移到环节质监控上来。%In order to improve the quality of the medical record writing quality, the establishment of strict medical record quality control management system, implementation of the medical record quality self control, supervision and control and terminal control, using the method of PDCA to chase class to be in charge, the monitoring results feedback to the school level network and all the departments to the quality of briefings, and at the same time was reported to be in weekly. The medical record quality center of gravity from the final quality transfer to link quality monitoring.

  10. A practical method for the assessment of daylight-responsive lighting control systems regarding energy savings and lighting quality

    Energy Technology Data Exchange (ETDEWEB)

    Belendorf, H.; Aydinli, S.; Kaase, H. [Technical Univ. of Berlin, Inst. for Electronics and Lighting Technology, Berlin (Germany)

    2000-07-01

    The increased utilization of daylight-responsive lighting-control systems in commercial buildings requires the possibility to compare different systems regarding energy and lighting performance. Measurements at the Technical University of Berlin (TUB) on various daylight-responsive lighting controls have been made analyzing the energy saving potential and ability to fulfill general lighting requirements. The paper describes a basis for the calculation founded on these test-measurements in 1:1 test-rooms in order to assess the energy and lighting performance of the system as well as calculating a general quantity (the system-triple) per room-zone to classify and compare different systems. The method meets practical requirements because it takes into account the official guidelines for lighting in offices (dependent on the specific country, e.g. in Germany the standard DIN5035 'Artificial Lighting of Interiors' or other equivalent European standards). The quantity called system-triple consists of three numbers, of which one number describes the energy saving performance (system-potential), the other two relate to the behavior towards its maintaining the requirements to the illuminance level in the room (relative short-coming and exceeding light exposure). The system-potential tends to be independent from the sky-condition, although the situation in which the system is going to be applied has quite an influence on the system-potential. The method is an essential part of a comprehensive procedure, developed at the TUB, for predicting the energy saving potential regarding electric lighting in an office equipped with daylight-following lighting control systems. (au)

  11. Empirical evaluation of humpback whale telomere length estimates; quality control and factors causing variability in the singleplex and multiplex qPCR methods

    Directory of Open Access Journals (Sweden)

    Olsen Morten

    2012-09-01

    Full Text Available Abstract Background Telomeres, the protective cap of chromosomes, have emerged as powerful markers of biological age and life history in model and non-model species. The qPCR method for telomere length estimation is one of the most common methods for telomere length estimation, but has received recent critique for being too error-prone and yielding unreliable results. This critique coincides with an increasing awareness of the potentials and limitations of the qPCR technique in general and the proposal of a general set of guidelines (MIQE for standardization of experimental, analytical, and reporting steps of qPCR. In order to evaluate the utility of the qPCR method for telomere length estimation in non-model species, we carried out four different qPCR assays directed at humpback whale telomeres, and subsequently performed a rigorous quality control to evaluate the performance of each assay. Results Performance differed substantially among assays and only one assay was found useful for telomere length estimation in humpback whales. The most notable factors causing these inter-assay differences were primer design and choice of using singleplex or multiplex assays. Inferred amplification efficiencies differed by up to 40% depending on assay and quantification method, however this variation only affected telomere length estimates in the worst performing assays. Conclusion Our results suggest that seemingly well performing qPCR assays may contain biases that will only be detected by extensive quality control. Moreover, we show that the qPCR method for telomere length estimation can be highly precise and accurate, and thus suitable for telomere measurement in non-model species, if effort is devoted to optimization at all experimental and analytical steps. We conclude by highlighting a set of quality controls which may serve for further standardization of the qPCR method for telomere length estimation, and discuss some of the factors that may cause

  12. A GC-FID validated method for the quality control of Eucalyptus globulus raw material and its pharmaceutical products, and gc-ms fingerprinting of 12 Eucalyptus species.

    Science.gov (United States)

    Buenoa, Paula Carolina Pires; Junior, Milton Groppo; Bastos, Jairo Kenupp

    2014-12-01

    In this work we have validated a method to standardize and control the quality of Eucalyptus globulus raw material and phytomedicines containing either the essential oil or the fluid extract of this plant in the final formulation. Internal standardization provided a simple, fast, and reproducible GC-FID analytical method that accurately quantified 1,8-cineol in different E. globulus sub-products, such as its essential oil, dried leaves, fluid extract, and syrup. In addition, GC-MS identification of the main compounds ofE. globulus species afforded fingerprints for the qualitative analysis of different Eucalyptus species.

  13. Frontiers in statistical quality control

    CERN Document Server

    Wilrich, Peter-Theodor

    2001-01-01

    The book is a collection of papers presented at the 5th International Workshop on Intelligent Statistical Quality Control in Würzburg, Germany. Contributions deal with methodology and successful industrial applications. They can be grouped in four catagories: Sampling Inspection, Statistical Process Control, Data Analysis and Process Capability Studies and Experimental Design.

  14. Quality Control in Production Processes

    Directory of Open Access Journals (Sweden)

    Prístavka Miroslav

    2016-09-01

    Full Text Available The tools for quality management are used for quality improvement throughout the whole Europe and developed countries. Simple statistics are considered one of the most basic methods. The goal was to apply the simple statistical methods to practice and to solve problems by using them. Selected methods are used for processing the list of internal discrepancies within the organization, and for identification of the root cause of the problem and its appropriate solution. Seven basic quality tools are simple graphical tools, but very effective in solving problems related to quality. They are called essential because they are suitable for people with at least basic knowledge in statistics; therefore, they can be used to solve the vast majority of problems.

  15. Quality control of seasonal influenza vaccines.

    Science.gov (United States)

    Mandušić Nazor, Tamara; Pipić Kosanović, Marta; Tomić, Siniša

    2010-12-01

    The purpose of seasonal influenza vaccination is to prevent its spread. The vaccines contain strains of the influenza virus recommended and approved for a particular season. Just like any other medicinal product, all vaccines require marketing approval. Batches of approved vaccines are extensively tested by the manufacturers and additionally controlled by the approving authorities, which issue the quality control certificates. This article not only to describes the legal background of quality control, but also how control test results obtained by a Croatian official control laboratory are compared to manufacturer's results. We have found that testing results can slightly differ depending on methods/analytical procedures used in different laboratories. This investigation has also shown how important it is to test finished medicinal products, independently of testing at intermediate stages, and how retesting by control authorities ensures that marketed vaccines meet quality standards.

  16. Development of an in-line HPLC fingerprint ion-trap mass spectrometric method for identification and quality control of Radix Scrophulariae.

    Science.gov (United States)

    Jing, Jing; Chan, Chi-on; Xu, Lijia; Jin, Dengping; Cao, Xinwei; Mok, Daniel K W; Parekh, H S; Chen, Sibao

    2011-12-05

    Chromatographic fingerprinting has been widely accepted as a crucial method for qualitative and quantitative analyses of bioactives within traditional Chinese medicine. A fingerprint provides detailed information, specific for any given herb, thus facilitating the quality control measures of a given traditional Chinese medicine. In this article, quality assessment of Radix Scrophulariae was achieved by using high performance liquid chromatography combining diode-array detection and electrospray ionization mass spectrometry (HPLC-DAD-ESI/MS). Eight batches of sample obtained from different origins in China were used to establish the fingerprint and quantitative analyses. By comparing the retention times, UV and MS spectral data with reference standards, four characteristic peaks in the chromatograms were confirmed as corresponding to acetoside, angoroside C, cinnamic acid, and harpagoside. In addition, other two characteristic peaks were tentatively identified, following the literature interpretation of HPLC-ESI-MS and LC-MS/MS (affording structural information) to be sibirioside A and scrophuloside B(4), respectively. The results indicated that the newly developed HPLC-DAD-MS fingerprint method would be suitable for quality control of Radix Scrophulariae.

  17. Discovery of discriminatory quality control markers for Chinese herbal medicines and related processed products by combination of chromatographic analysis and chemometrics methods: Radix Scutellariae as a case study.

    Science.gov (United States)

    Wang, Fei; Wang, Bo; Wang, Long; Xiong, Zi-Yue; Gao, Wen; Li, Ping; Li, Hui-Jun

    2017-05-10

    The processing procedure of traditional Chinese herbal medicines (CHMs) plays an essential role in clinical applications. However, little progress has been made on the quality control of crude and processed products. The present work, taking Radix Scutellariae (RS), wine-processed RS and carbonized RS as a typical case, developed a comprehensive strategy integrating chromatographic analysis and chemometric methods for quality evaluation and discrimination of crude RS and its processed products. Chemical fingerprints were established by high-performance liquid chromatography coupled with photodiode array detector and quadrupole time-of-flight mass spectrometry, and similarity analyses were calculated based on eleven common characteristic peaks. Subsequently, four chemical markers were discovered by back propagation-artificial neural network (BP-ANN) modeling. The selected markers were quantified by the 'single standard to determine multi-components' (SSDMC) method, and then the quantitative data were subjected to principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA). Furthermore, support vector machine (SVM) was employed to predict the different processed products of RS. Finally, a hotmap visualization was conducted for clarifying the distribution of major flavonoids among different drugs. Collectively, the proposed strategy might be well-acceptable for quality control of CHMs and their related processed products from the processing mechanism-based perspective. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Investigation of the contribution possibilities of non-destructive methods of testing for the diagnosis and quality control of building materials with emphasis given on sustainable construction

    Science.gov (United States)

    Katsiotis, Nikolaos S.; Matikas, Theodoros E.; Moropoulou, Antonia

    2012-04-01

    In this work, the contribution potential of non-destructive methods of testing is studied in order to assess, diagnose and assert building materials' diagnosis & quality control, with emphasis given on Sustainable Construction. To this end, the following techniques are implemented: fiber-optics microscopy, digital image processing, scanning electron microscopy, pulse/lock-in thermography, acoustic emission as well as ultrasounds. Furthermore, in addition to the above, the maturity method for measurement of compressive strength is applied and correlated to the array of full field non-destructive methods of testing. The results of the study clearly demonstrate how effective non-destructive methods of testing can be, in revealing and determining highly applicable data in a real-time, in situ and efficient manner.

  19. Control system design method

    Science.gov (United States)

    Wilson, David G [Tijeras, NM; Robinett, III, Rush D.

    2012-02-21

    A control system design method and concomitant control system comprising representing a physical apparatus to be controlled as a Hamiltonian system, determining elements of the Hamiltonian system representation which are power generators, power dissipators, and power storage devices, analyzing stability and performance of the Hamiltonian system based on the results of the determining step and determining necessary and sufficient conditions for stability of the Hamiltonian system, creating a stable control system based on the results of the analyzing step, and employing the resulting control system to control the physical apparatus.

  20. A Simple and Rapid Method for Quality Control of Major Histocompatibility Complex-Peptide Monomers by Flow Cytometry.

    Science.gov (United States)

    Chandran, P Anoop; Heidu, Sonja; Zelba, Henning; Schmid-Horch, Barbara; Rammensee, Hans-Georg; Pascolo, Steve; Gouttefangeas, Cécile

    2017-01-01

    Major histocompatibility complex (MHC) multimers are essential tools in T cell immunomonitoring, which are employed both in basic and clinical research, as well as for assessing clinical samples during therapy. The generation of MHC monomers loaded with synthetic peptides is an elaborate and time-consuming process. It would be beneficial to assess the quality of these monomers prior to downstream applications. In this technical note, we describe a novel flow cytometry-based, cell-free, quick, and robust assay to check the quality of MHC monomers directly after refolding or after long-term storage.

  1. A Simple and Rapid Method for Quality Control of Major Histocompatibility Complex–Peptide Monomers by Flow Cytometry

    Science.gov (United States)

    Chandran, P. Anoop; Heidu, Sonja; Zelba, Henning; Schmid-Horch, Barbara; Rammensee, Hans-Georg; Pascolo, Steve; Gouttefangeas, Cécile

    2017-01-01

    Major histocompatibility complex (MHC) multimers are essential tools in T cell immunomonitoring, which are employed both in basic and clinical research, as well as for assessing clinical samples during therapy. The generation of MHC monomers loaded with synthetic peptides is an elaborate and time-consuming process. It would be beneficial to assess the quality of these monomers prior to downstream applications. In this technical note, we describe a novel flow cytometry-based, cell-free, quick, and robust assay to check the quality of MHC monomers directly after refolding or after long-term storage. PMID:28228758

  2. 大型舰船修理技术文件编制质量控制%Quality Control Method of Producing Technical Documentation for Ship Maintenance

    Institute of Scientific and Technical Information of China (English)

    王永德; 关静; 陈志敏; 阳斌

    2015-01-01

    针对目前大型舰船修理技术文件普遍存在的问题,参考国外相关经验,提出大型舰船修理技术文件编制质量控制方法,从管理和技术两个方面对文件质量进行控制把关,并且通过控制该修理技术文件的编制过程以有效促进大型舰船装备同步形成保障能力。%Aiming at the problems existing universally in the maintenance technical documentation of ship-repairing for large ships, the related experiences are referenced to set forth a quality control method of producing technical documentation for ship maintenance.The method can not only control and check the quality of the maintenance technical documentation from both man-agement and technology, but also can be helpful for the equipment on large ship forming logistic capability synchronously by con-trolling the production of the documentation.

  3. Construction Quality Control Method of Building Mechanical and Electrical Installation%建筑机电安装施工质量的控制方法

    Institute of Scientific and Technical Information of China (English)

    陈忠伟

    2014-01-01

    This paper first of al introduces the construction machinery instal ation, and points out some problems existing in the construction, meanwhile the corresponding solution and countermeasures are discussed. This paper also introduces the construction quality control method of building mechanical and electrical instal ation by stages, in order to ensure cons-truction quality and safety.%本文首先对建筑机电安装进行了简单地介绍,指出了建筑机电工程施工过程中存在的一些问题,同时探讨了解决的办法以及应对措施。并分阶段对机电安装施工质量的控制方法进行了介绍,以确保施工过程质量有保证、安全有保障。

  4. Discussing Interior Quality Control Method of ELISA Qualitative Test%ELISA法定性试验室内质控方法探讨

    Institute of Scientific and Technical Information of China (English)

    丁海明; 潘婉仪

    2011-01-01

    Objective To discuss ELISA qualitative test inside quality control method. Methods Detected HBsAg,HBsAb,HBeAg,HBeAb and HBcAb of weakly positive oc matter and 900 patients serum by ELISA method,analyse QC data with Levey-Jennings and half hold range method. Results 25 patients serum in 900 patients serum appeared false-negative and false-positive alone utilize Levey-Jennings QC map. Conclusion Combine Levey-Jennings oc map and half hold range method wben utilize ELISA qualitative test interior quality control method,reasonable choose fit experimental QC method by experimentation purpose.%目的 探讨ELISA法定性试验室内质控方法.方法 以ELISA法检测弱阳性质控品和900份病人血清的HBsAg,HBsAb,HBeAg,HBeAb和HBcAb,用Levey-Jennings质控图法和半固定范围法分别分析质控数据.结果 单独应用Levey-Jennings质控图法时,900份血清中有25份标本阴阳性出现误判.结论 在应用ELISA法定性试验室内质控方法时,结合Levey-Jennings质控图法和半固定范围法,根据实验目的合理选择适合各实验的质控方法.

  5. Improved Quality Control Method for Prescriptions of Polygonum capitatum through Simultaneous Determination of Nine Major Constituents by HPLC Coupled with Triple Quadruple Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Jun Zhang

    2013-09-01

    Full Text Available As a traditional Miao-nationality medicinal plant, Polygonum capitatum has been used in clinical practice for several thousand years. Its prescriptions, including three dosage forms: granules, capsule and tablet are known by the brand name Relinqing® and have played an indispensable role in the treatment of urinary system infection, pyelonephritis and kidney stones. However, no study about the comprehensive quality evaluation of Relinqing® has been reported. In the present paper, a method for the simultaneous determination of nine major compounds in three dosage forms of Relinqing® using HPLC coupled with triple quadrupole mass spectrometry (HPLC-QQQ MS was established to comprehensively evaluate their quality. The nine compounds, including four phenolic acids, four flavonoids and a lignin, were analyzed with acceptable linear regression relationship (r2, 0.9923–0.9992, precision (RSD, 1.25%–2.78%, repeatability (RSD, 2.05%%–3.47%, stability (RSD, 1.84%–3.72% and recovery (93.60%–108.54%, RSD ≤ 3.67%. The present study fills the gap in the multivariate quality control of Relinqing® and provides a valuable reference for quality standards and dosage reforming of this traditional Chinese medicine.

  6. 交通数据质量宏观评价与控制方法%Macroscopic Evaluation and Control Method of Traffic Data Quality

    Institute of Scientific and Technical Information of China (English)

    牛世峰; 姜桂艳

    2012-01-01

    针对交通数据质量微观评价方法无法评价交通数据整体质量的问题,提出交通数据宏观评价的思想,在对非正常交通数据分类进行研究的基础上,构建了4个交通数据宏观评价指标,并设计了交通数据宏观评价流程,根据各类非正常交通数据的产生原因,设计了交通数据质量宏观控制方法,利用实测数据验证表明,所设计方法可以实现交通数据质量的宏观评价,并能给出合理的交通数据质量控制策略.%In the light of the problem which evaluate the overall quality of traffic data, the idea of macroscopic evaluation of traffic data is proposed. Four macroscopic evaluation indexes of traffic data are constructed based on the classification of non-normal traffic data, and the flow of macroscopic evaluation of traffic data quality is designed. The macroscopic control method of traffic data quality is designed based on cause analysis of non-normal data. The experimental results indicate that the proposed method can carry out the macroscopic evaluate of traffic data quality, and give a reasonable data quality improvement strategy.

  7. Frontiers in statistical quality control

    CERN Document Server

    Wilrich, Peter-Theodor

    1997-01-01

    Like the preceding volumes, and met with a lively response, the present volume is collecting contributions stressed on methodology or successful industrial applications. The papers are classified under four main headings: sampling inspection, process quality control, data analysis and process capability studies and finally experimental design.

  8. Methods of inventory control.

    Science.gov (United States)

    Lindley, C; Mackowiak, J

    1985-01-01

    Various methods for controlling inventory are described, and the advantages and disadvantages of each are discussed. The open-to-buy (OTB) budget method limits purchases to a specific amount of funds available for purchasing pharmaceuticals during a specified period. The emphasis of the OTB method is financial control of the pharmacy inventory. Although it is useful in monitoring and adjusting the dollar value of the inventory, it should be combined with other methods for a total inventory control system. The primary emphasis of the short-list method is to provide accurate and timely inventory information to the person responsible for order placement. The short list identifies the items that are in short supply. It is the most common feedback and control mechanism in use, but it is best suited for settings where duplicate or reserve stock is maintained and monitored by more rigorous methods. The main objective of the minimum and maximum method is to determine when and how much to order of each item. It also provides limited dollar control. The major disadvantage of this method is the time it requires to establish the minimum and maximum levels and to update them regularly to reflect changes in demand. The stock record card method is used to record information on the movement of goods in and out of the storage area. Stock cards can also be used to monitor inventory levels and facilitate order initiation. It is probably the optimum method to be used alone. The most effective system of inventory control is one employing a combination of these methods tailored to meet the institution's needs and available resources.

  9. Empirical evaluation of humpback whale telomere length estimates; quality control and factors causing variability in the singleplex and multiplex qPCR methods

    DEFF Research Database (Denmark)

    Olsen, Morten Tange; Berube, Martine; Robbins, Jooke

    2012-01-01

    BACKGROUND:Telomeres, the protective cap of chromosomes, have emerged as powerful markers of biological age and life history in model and non-model species. The qPCR method for telomere length estimation is one of the most common methods for telomere length estimation, but has received recent...... critique for being too error-prone and yielding unreliable results. This critique coincides with an increasing awareness of the potentials and limitations of the qPCR technique in general and the proposal of a general set of guidelines (MIQE) for standardization of experimental, analytical, and reporting...... steps of qPCR. In order to evaluate the utility of the qPCR method for telomere length estimation in non-model species, we carried out four different qPCR assays directed at humpback whale telomeres, and subsequently performed a rigorous quality control to evaluate the performance of each assay. RESULTS...

  10. 食品微生物检验的方法及质量控制%Method and Quality Control of Food Microbiological Examination

    Institute of Scientific and Technical Information of China (English)

    赵春艳

    2016-01-01

    The food industry has the particularity of the distribution, with the continuous improvement of people's living standards, the food safety inspection requirements are also continuously improved, so need to strengthen the inspection and control of microorganisms. Vigorously developing science and technology, the study of new inspection methods, and rapid promotion and popularization of effective detection technology are more important. Based on this, this paper analyzed the methods and quality control of food microbiological testing, which is aimed at improving the detection effciency and quality.%食品行业具有流通快的特殊性,随着生活水平的不断提高,人们逐渐提高了食品安全检验的要求,因此需要加强对食品微生物的检测和控制。大力发展科学技术,研究新检验方法,快速推广普及有效检测技术越显重要。基于此,分析食品微生物检验的方法和质量控制,旨在不断提高检测效率和检验质量。

  11. Validación de métodos analíticos para el control de calidad de naproxeno supositorios Validation of analytical methods for the quality control of Naproxen suppositories

    Directory of Open Access Journals (Sweden)

    Yaslenis Rodríguez Hernández

    2011-09-01

    Full Text Available En el presente trabajo se desarrollaron por primera vez, los métodos de análisis que serán utilizados para el control de calidad de las futuras formulaciones de supositorios de naproxeno, para uso infantil y adulto de producción nacional. Se propuso un método por espectrofotometría ultravioleta directa, el cual resultó específico, lineal, exacto y preciso para su aplicación en el control de calidad del naproxeno en supositorios, teniendo en cuenta la presencia de grupos cromóforos en su estructura. Se modificó el método por volumetría ácido-base semiacuosa directa reportado para control de calidad de la materia prima de naproxeno y se adaptó al control de calidad en los supositorios. A partir del proceso de validación realizado, se demostró la adecuada especificidad frente a los componentes de la formulación, así como su linealidad, exactitud y precisión en el rango de 1 a 3 mg/mL. Se compararon los resultados obtenidos por ambos métodos sin detectar diferencias estadísticamente significativas entre las réplicas analizadas por cada dosis, por lo que cualquiera de ellos pueden aplicarse al control de calidad de los supositorios.The analysis methods that will be used for the quality control of the future Cuban-made Naproxen suppositories for adults and children were developed for the first time in this paper. One method based on direct ultraviolet spectrophotometry was put forward, which proved to be specific, linear, accurate and precise for the quality control of Naproxen suppositories, taking into account the presence of chromophore groups in their structure. Likewise, the direct semi-aqueous acid-base volumetry method aimed at the quality control of the Naproxen raw material was changed and adapted to the quality control of suppositories. On the basis of the validation process, there was demonstrated the adequate specificity of this method with respect to the formulation components, as well as its linearity, accuracy and

  12. Quality Assurance/Quality Control Jobs

    Science.gov (United States)

    Fanslau, Melody; Young, Janelle

    The production of a quality and safe food product is essential to the success of any food manufacturing facility. Because of this great importance, a career in quality can be extremely rewarding. Without happy customers willing to buy a product, a company would not be able to survive. Quality issues such as foreign objects, spoiled or mislabeled product, failure to meet net weight requirements, or a recall can all turn customers away from buying a product. The food industry is a customer-driven market in which some consumers are brand loyal based on a history of high quality or in which a single bad experience with a product will turn them away for a lifetime. With this said, the main role of a quality department is to help ensure that quality issues such as these are eliminated or kept to a minimum to maintain or increase the number of customers purchasing their product.

  13. Quality Improvement in Surgery Combining Lean Improvement Methods with Teamwork Training: A Controlled Before-After Study.

    Directory of Open Access Journals (Sweden)

    Eleanor Robertson

    Full Text Available To investigate the effectiveness of combining teamwork training and lean process improvement, two distinct approaches to improving surgical safety. We conducted a controlled interrupted time series study in a specialist UK Orthopaedic hospital incorporating a plastic surgery team (which received the intervention and an Orthopaedic theatre team acting as a control.We used a 3 month intervention with 3 months data collection period before and after it. A combined teamwork training and lean process improvement intervention was delivered by an experienced specialist team. Before and after the intervention we evaluated team non-technical skills using NOTECHS II, technical performance using the glitch rate and WHO checklist compliance using a simple 3 point scale. We recorded complication rate, readmission rate and length of hospital stay data for 6 months before and after the intervention.In the active group, but not the control group, full compliance with WHO Time Out (T/O increased from 14 to 71% (p = 0.032, Sign Out attempt rate (S/O increased from 0% to 50% (p<0.001 and Oxford NOTECHS II scores increased after the intervention (P = 0.058. Glitch rate decreased in the active group and increased in the control group (p = 0.001. Complications and length of stay appeared to rise in the control group and fall in the active group.Combining teamwork training and systems improvement enhanced both technical and non-technical operating team process measures, and were associated with a trend to better safety outcome measures in a controlled study comparison. We suggest that approaches which address both system and culture dimensions of safety may prove valuable in reducing risks to patients.

  14. Assay method for quality control and stability studies of a new anti-diabetic and anti-dyslipidemic flavone (S002-853FNx01

    Directory of Open Access Journals (Sweden)

    Arshi Naqvi

    2015-01-01

    Full Text Available Background: Flavonoid-rich extract of the plant is long known for its anti-diabetic activities in traditional medicine. S002-853, a new flavone derivative synthesized by Central Drug Research Institute (CDRI has been used for the present study. Objectives: The present study aimed at development of an assay method for quality control (QC and stability studies of a new anti-diabetic and anti-dyslipidemic agent CDRI compound S002-853. Materials and Methods: A validated high-performance liquid chromatography analysis method for S002-853 was developed for in process QC and stability studies. The separation was achieved on a RP-C18 (25 cm × 0.4 cm, 5 μm, Phenomenex at 240 nm with flow rate of 1.0 ml/min. This method was applied successfully in establishing forced degradation and drug-excipient testing protocols as per International Conference on Harmonization guidelines. Results: The result of estimation and stress testing studies indicated a high degree of selectivity of this method. S002-853 was most stable at pH 7 and under photolytic conditions. The temperature degradation pattern of S002-853 was found to follow the zero order degradation. Conclusion: The method described is easy and simple hence can be easily reproduced. This method can be very useful for bulk manufacture QC, and drug development process.

  15. Coordinating fingerprint determination of solid-phase microextraction/gas chromatography-mass spectrometry and chemometric methods for quality control of oxidized tallow.

    Science.gov (United States)

    Song, Shiqing; Zhang, Xiaoming; Hayat, Khizar; Xiao, Zuobing; Niu, Yunwei; Eric, Karangwa

    2013-02-22

    Based on optimized solid-phase microextraction/gas chromatography-mass spectrometry (SPME/GC-MS) and chemometric methods, simple, reliable and reproducible methods were described for the first time for developing a chromatographic fingerprint of oxidized tallow. Eight optimal oxidized tallow samples were used to establish the chromatographic fingerprint. Spectral correlative chromatogram was adopted to identify 33 "common components". The validation of fingerprint analysis was performed based on the relative retention time, the relative peak area of common peaks, sample stability and similarity analysis. The correlation coefficient of similarity of eight optimal oxidized tallow samples was more than 0.962, which showed that samples from different batches were consistent to some extent in spite of slightly different chemical indexes. Through principal component analysis (PCA), 14 constituents were further screened out to be the main chemical markers, which could be applied to more accurate quantitative discrimination and quality control of oxidized tallow.

  16. Method of Analysis by the U.S. Geological Survey California District Sacramento Laboratory-- Determination of Dissolved Organic Carbon in Water by High Temperature Catalytic Oxidation, Method Validation, and Quality-Control Practices

    Science.gov (United States)

    Bird, Susan M.; Fram, Miranda S.; Crepeau, Kathryn L.

    2003-01-01

    An analytical method has been developed for the determination of dissolved organic carbon concentration in water samples. This method includes the results of the tests used to validate the method and the quality-control practices used for dissolved organic carbon analysis. Prior to analysis, water samples are filtered to remove suspended particulate matter. A Shimadzu TOC-5000A Total Organic Carbon Analyzer in the nonpurgeable organic carbon mode is used to analyze the samples by high temperature catalytic oxidation. The analysis usually is completed within 48 hours of sample collection. The laboratory reporting level is 0.22 milligrams per liter.

  17. Softcopy quality ruler method: implementation and validation

    Science.gov (United States)

    Jin, Elaine W.; Keelan, Brian W.; Chen, Junqing; Phillips, Jonathan B.; Chen, Ying

    2009-01-01

    A softcopy quality ruler method was implemented for the International Imaging Industry Association (I3A) Camera Phone Image Quality (CPIQ) Initiative. This work extends ISO 20462 Part 3 by virtue of creating reference digital images of known subjective image quality, complimenting the hardcopy Standard Reference Stimuli (SRS). The softcopy ruler method was developed using images from a Canon EOS 1Ds Mark II D-SLR digital still camera (DSC) and a Kodak P880 point-and-shoot DSC. Images were viewed on an Apple 30in Cinema Display at a viewing distance of 34 inches. Ruler images were made for 16 scenes. Thirty ruler images were generated for each scene, representing ISO 20462 Standard Quality Scale (SQS) values of approximately 2 to 31 at an increment of one just noticeable difference (JND) by adjusting the system modulation transfer function (MTF). A Matlab GUI was developed to display the ruler and test images side-by-side with a user-adjustable ruler level controlled by a slider. A validation study was performed at Kodak, Vista Point Technology, and Aptina Imaging in which all three companies set up a similar viewing lab to run the softcopy ruler method. The results show that the three sets of data are in reasonable agreement with each other, with the differences within the range expected from observer variability. Compared to previous implementations of the quality ruler, the slider-based user interface allows approximately 2x faster assessments with 21.6% better precision.

  18. 7 CFR 58.442 - Laboratory and quality control tests.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Laboratory and quality control tests. 58.442 Section... Service 1 Operations and Operating Procedures § 58.442 Laboratory and quality control tests. (a) Chemical... Methods or by other methods giving equivalent results. (b) Weight or volume control....

  19. Developing a TQM quality management method model

    OpenAIRE

    Zhang, Zhihai

    1997-01-01

    From an extensive review of total quality management literature, the external and internal environment affecting an organization's quality performance and the eleven primary elements of TQM are identified. Based on the primary TQM elements, a TQM quality management method model is developed. This model describes the primary quality management methods which may be used to assess an organization's present strengths and weaknesses with regard to its use of quality management methods. This model ...

  20. Development and Validation of a GC-MS Method for Rapid Determination of Calophyllolide in Calophyllum inophyllum L.: A Quality Control Approach%Development and Validation of a GC-MS Method for Rapid Determination of Calophyllolide in Calophyllum inophyllum L.:A Quality Control Approach

    Institute of Scientific and Technical Information of China (English)

    Ha Minh Hien; Paul WS Heng; Nguyen Van Thi; Nguyen Khac Quynh Cu; Vo Thi Bach Hue

    2011-01-01

    AIM:To establish a GC-MS method for the determination of calophyllolide in Calophyllum inophyllum L.and its application in quality control of natural medicine.METHODS:Methanolic extract from Calophyllum inophyllum L.was prepared.Calophyllolide was isolated,purified and then identified to serve as a chemical marker for development and validation a GC-MS method according to ICH guideline and USP.The established method was proved to be useful in quality control with the aid of Principle Component Analysis (PCA),a multivariate data analysis technique.RESULTS:The proposed method was selective against mass spectral deconvoluting software AMDIS32.The linear range was from 3.125-50 tg.mL-1.The RSD of intra-and inter-day precision variations were less than 3% and the mean recovery was (101.22 ± 1.98) % (RSD = 1.95%).PCA was used to indicate a differentiation of batches in production as well as proving that calophyllolide has influence on the discrimination of extracts from different batches.CONCLUSION:The proposed capillary gas chromatography/mass spectrometric method for the determination of calophyllolide obtained from resin of Calophyllum inophyllum L.nut oil showed its suitability,simplicity,rapidity and precision,and it can be used for chemical assay.This is the first time such a technique was reported in literature.The multivariate data analysis technique was employed to provide an extensive but inclusive method for quality control of the extracts,to ensure consistency for batch to batch of extracts to be used for product development.

  1. Fast HPLC for quality control of Harpagophytum procumbens by using a monolithic silica column: method transfer from conventional particle-based silica column.

    Science.gov (United States)

    Schmidt, Alexander H

    2005-05-06

    The applicability of a monolithic C18-bonded silica column for the rapid HPLC separation of ingredients in medicinal plants and their phytopharmaceutical preparations has been evaluated in the author's laboratory. In this presentation, an existing method for the determination of the iridoid glycoside harpagoside in Harpagophytum procumbens (Devil's Claw) was successfully transferred from a conventional particle-based C18 silica column to a monolithic silica column. The very high porosity of the stationary phase allows chromatography with a much lower backpressure than on conventional columns. Therefore, the flow rate could be easily increased from 0.8 mL/min (particle-based column) to 5 mL/min (monolithic column) and the run-time reduced from 30 to 5 min (that is a reduction about 85% !), without losing any chromatographic resolution of the compound of interest. The amount of harpagoside was measured with the original method on a conventional particle-based silica column and on the adapted method on a monolithic silica column. The statistical mean t-test showed no significant differences of the variances and the means indicating that the fast HPLC method is an acceptable alternative. The shorter analysis time makes the method very valuable for commercial quality control of Harpagophytum extracts and its pharmaceutical preparations.

  2. Comparison of false negative rates between 100% rapid review and 10% random full rescreening as internal quality control methods in cervical cytology screening.

    Science.gov (United States)

    Lee, Benjamin Chi Kui; Lam, Sui Yue; Walker, Todd

    2009-01-01

    To compare and contrast the 100% partial rapid review (RR) method against 10% randomly selected full rescreening to determine the better means of internal quality control (QC) by which the cervical screening laboratory should adopt. A total of 4,150 conventional Pap smears reported as negative during 2003 were 100% rescreened rapidly in large field jumps. From this cohort, 415 (10%) were selected again randomly for full rescreening. The false negative rates (FNRs) were calculated and compared accordingly. The 100% RR method reclassified 30 false negative (FN) cases, while the 10% random full rescreening reclassified only 5. The FNRs were calculated to be 8.2% and 12.9%, respectively. A chi2 test (p FNRs calculated by both methods. The 100% RR proved to be a better method for QC purpose in reducing the FNRs and detected more missing cases. This study is the first of its type from Hong Kong and confirms previous publications from elsewhere that 100% RR is a better method for internal QC in cervical cytology screening.

  3. Types of slow/controlled release fertilizer and its quality evaluation method%缓/控释肥料类型及质量评价方法

    Institute of Scientific and Technical Information of China (English)

    杨红竹; 郑国亮; 刘海林; 林清火; 罗微

    2016-01-01

    缓/控释肥料具有减少养分淋失、挥发损失,提高肥料利用率等诸多优点,近年来在国内发展尤其迅速,是今后肥料发展的主要方向之一。介绍缓/控释肥料的概念、分类和质量评价方法,并对今后的研究方向进行展望。%S low/controlled release fertilizers has many advantages, such as it can improve the uptake of nutrients by plants, reduce possible losses of nutrients and losses of ammonia. In recent years, slow/controlled release fertilizers develops fastly in domestic market. Slow/controlled release fertilizers is one of the main direction for the future development of fertilizer. This paper introduceds the concept, classification and quality evaluation method of slow/controlled release fertilizer, and looks forward to the future research.

  4. 缓控释肥质量快速检测方法探讨%Discussion on rapid quality detection method for slow/controlled release fertilizers

    Institute of Scientific and Technical Information of China (English)

    陈剑秋; 葛雨明; 孙德芳; 王丽萍; 张民

    2012-01-01

    Based on nutrient release testing method for quality detection experiment, the difference between of slow/controlled release fertilizers standard testing method and rapid is studied. The results show that error range between rapid method and standard method is from 2.7% to 8.3% for CRF1, CRF2, CRF3 and CRF4, which completely meet the demand of national standard of GB/T 23348--2009 about error range (25%); For the products (CRF5 to CRF16) with the production conditions changed such as envelope materials, additives and spraying temperature, the evaluation of slow/controlled release fertilizers is not reliable with the original prediction equation; So one prediction equation can't be used to rapidly and accurately detect every slow/controlled release fertilizer.%通过缓控释肥养分释放试验,研究了缓控释肥标准检测方法与快速测定方法的差异。结果表明:供试CRF1至CRF4样品快速测定方法与标准方法误差范围为2.7%~8-3%,完全满足GB/T23348--2009养分释放期允许误差范围25%的要求;在改变包膜材料、添加剂和喷涂温度条件下,制成的CRF5至CRF16样品采用快速测定方法用原有预测方程预测养分释放期可靠性差,表明一个预测方程不能快速准确评价所有缓控释肥。

  5. Determination and evaluation of air quality control. Manual of ambient air quality control in Germany

    Energy Technology Data Exchange (ETDEWEB)

    Lahmann, E.

    1997-07-01

    Measurement of air pollution emissions and ambient air quality are essential instruments for air quality control. By undertaking such measurements, pollutants are registered both at their place of origin and at the place where they may have an effect on people or the environment. Both types of measurement complement each other and are essential for the implementation of air quality legislation, particularly, in compliance with emission and ambient air quality limit values. Presented here are similar accounts of measurement principles and also contains as an Appendix a list of suitability-tested measuring devices which is based on information provided by the manufacturers. In addition, the guide of ambient air quality control contains further information on discontinuous measurement methods, on measurement planning and on the assessment of ambient air quality data. (orig./SR)

  6. Family Control and Earnings Quality

    Directory of Open Access Journals (Sweden)

    Carolina Bona Sánchez

    2007-06-01

    Full Text Available El trabajo analiza la relación entre el control familiar y la calidad de la información contable en un contexto en el que el tradicional conflicto de agencia entre directivos y accionistas se desplaza a la divergencia de intereses entre accionistas controladores y minoritarios. Los resultados alcanzados muestran que, en comparación con las no familiares, las empresas de naturaleza familiar divulgan unos resultados de mayor calidad, tanto en términos de menores ajustes por devengo discrecionales como de mayor capacidad de los componentes actuales del resultado para predecir los cash flows futuros. Además, el aumento en los derechos de voto en manos de la familia controladora incrementa la calidad de los resultados contables. La evidencia obtenida se muestra consistente con la presencia de un efecto reputación/vinculación a largo plazo asociado a la empresa familiar. Adicionalmente, el trabajo refleja que a medida que disminuye la divergencia entre los derechos de voto y de cash flow en manos de la familia controladora, aumenta la calidad de la información contable.PALABRAS CLAVE: derechos de voto, divergencia, empresa familiar, calidad delresultado, reputación, beneficios privados.This work examines the relationship between family control and earnings quality in a context where the salient agency problem shifts away from the classical divergence between managers and shareholders to conflicts between the controlling owner and minority shareholders. The results reveal that, compared to non-family firms, family firms reveal higher earnings quality in terms of both lower discretionary accruals and greater predictability of future cash flows. They also show a positive relationship between the level of voting rights held by the controlling family and earnings quality. The evidence is consistent with the presence of a reputation/long-term involvement effect associated with the family firm. Moreover, the work reflects that, as the divergence

  7. A function-oriented quality control method for ship construction%以功能为导向的舰船建造质量控制方法

    Institute of Scientific and Technical Information of China (English)

    王鸿东; 梁晓锋; 余平; 易宏; 张裕芳

    2016-01-01

    长期以来,由于舰船建造工程浩大、过程复杂、工艺繁多,人们对于建造质量如何影响舰船可靠性缺乏系统性的研究。为实现对考虑建造质量影响的舰船可靠性的科学预测和有效控制,从舰船总体功能的角度出发,在现代造船模式背景下,针对舰船建造提出一种以功能为导向的质量控制(FOQC)方法。融合舰船目标功能、质量参数、建造工艺因素,提出舰船建造可靠性预测模型。建立工艺—质量参数及质量参数—特征功能可靠性模型,对预测模型进行量化计算,获得建造质量对舰船可靠性影响的定性与定量分析,并依据分析结果,对关键质量点与关键工艺环节进行控制与优化。以某舰船轴系安装为实例进行分析,验证了方法的可行性与有效性,可为舰船建造质量的定量化检验与评价提供基础性方法的原理指导。%As ship construction is a large-scale, complex and problematic process, it lacks systematic re⁃search into how construction quality influences ship reliability. Aiming at the purpose of predicting and controlling ship reliability, this paper proposes a Function-Oriented Quality Control (FOQC) method to manage a ship's overall functions under modern ship-building conditions. Based on the system reliability theory, a reliability prediction model for ship construction composed of such factors as ship function, quali⁃ty parameters and building process is proposed. We establish a quality-function reliability model and a pro⁃cess-quality model to both qualitatively and quantitatively calculate the impact of construction quality on ship reliability. According to the results, the control of key quality factors and processes can be implement⁃ed. The feasibility and effectiveness of the FOQC method are validated by a case involving the shafting in⁃stallation of a ship.

  8. Quality control in breast tomosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Jakubiak, R.R.; Messias, P.C.; Santos, M.F., E-mail: requi@utfpr.edu.br [Universidade Tecnologia Federal do Parana (UTFPR), Curitiba, PR (Brazil). Departamento Academico de Fisica; Urban, L.A.B.D., E-mail: lineiurban@hotmail.com [Diagnostico Avancado por Imagem, Curitiba, PR (Brazil)

    2015-07-01

    In Brazil, breast cancer is the most common and the leading cause of death among women, with estimated 57,000 new cases in 2014. The mammography (2D) plays an important role in the early detection of breast cancer, but in some cases can be difficult to detect malignant lesions due overlap of breast tissues. The Digital Breasts Tomosynthesis (DBT: 3D) reduces the effects of overlap, providing improved characterization of mammographic findings. However, the dose may double as compared with mammography. This study presents results of Contrast to Noise Ratio (CNR) and image quality evaluation on Siemens mammography equipment Mammomat Inspiration with tomosynthesis. The CNR was determined with Polymethylmethacrylate (PMMA) layers of 20 to 70 mm thick and an aluminum foils of 0,2 mm thickness and area of 10 mm². Image quality was assessed with the ACR Breast Simulator. In the evaluation of image quality, the detectability of fibers and masses was identical in 2D and 3D systems. Displaying fibers were 4,5 and 4 mass in both modes. In 2D mode were identified 3,5 microcalcifications groups, and 3D showed 3 groups. The Mean Glandular Dose (MGD) for the simulator in 2D mode was 1,17 mGy and 2,35 mGy for the 3D mode. The result reinforces the importance of quality control in the process of obtaining the images and obtained in accordance CNR values, ensuring image quality and compatible dose in 2D and 3D processes. (author)

  9. 40 CFR 51.359 - Quality control.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 2 2010-07-01 2010-07-01 false Quality control. 51.359 Section 51.359....359 Quality control. Quality control measures shall insure that emission testing equipment is calibrated and maintained properly, and that inspection, calibration records, and control charts...

  10. Integrated evaluation of HPLC and UV fingerprints for the quality control of Danshen tablet by systematic quantified fingerprint method combined with antioxidant activity.

    Science.gov (United States)

    Shi, Min; Sun, Guoxiang

    2017-03-20

    Danshen tablet, which consists of Salviae Miltiorrhizae Radix et Rhizoma, Notoginseng Radix et Rhizoma and Borneolum syntheticum, has been widely used in the therapy of cardiovascular disease. The aim of this study was to develop comprehensive evaluation methods for the quality control of Danshen tablet. First, five-wavelength fusion fingerprint was established to avoid one-sidedness of a single wavelength. Then, the ultraviolet spectrum fingerprint was applied to reflect the information of unsaturated bond and conjugated system of chemical substances in Danshen tablet. The similarity analyses of these two fingerprints were performed by systematic quantified fingerprint method in terms of qualitative and quantitative aspects. After that, the evaluation results of high-performance liquid chromatography and ultraviolet fingerprints were integrated by the mean algorithm, which could reduce the error caused by single method. The integrated evaluation results showed that 30 batches of samples were classified into seven grades. Finally, the fingerprint-efficacy relationship was established using an on-line antioxidant system and partial least squares model to explore the connection between chemical components and antioxidant activities. The methods established in this paper had proven to be suitable for the analysis of Danshen tablet. This article is protected by copyright. All rights reserved.

  11. Water quality benchmarking (WQB) and priority control screening (PCS) of persistent toxic substances (PTSs) in China: necessity, method and a case study.

    Science.gov (United States)

    He, Wei; Qin, Ning; Kong, Xiang-Zhen; Liu, Wen-Xiu; He, Qi-Shuang; Wang, Qing-Mei; Yang, Chen; Jiang, Yu-Jiao; Yang, Bin; Wu, Wen-Jing; Xu, Fu-Liu

    2014-02-15

    The priority control screening (PCS) and water quality benchmarking (WQB) of toxic chemicals in water are key steps to ensure the safety of drinking water and aquatic ecosystem that is the crucial goal of water environment management. Owing to the different levels of social-economic development in different countries and regions, the PCS and WQB of toxic chemicals must be determined in accordance with their specific water environment situations. However, in China, the PCS and WQB of toxic chemicals in water were mainly introduced from the other countries. A method for the PCS and WQB of toxic chemicals in water based on the ecological risks was proposed, and a platform named Bayesian Matbugs Calculator (BMC) was developed. As a case study, the WQB and PCS of sixty-nine PTSs based their ecological risks were performed on the basis of one-year monthly monitoring in Lake Chaohu. The results showed that the current national water quality criteria (WQC) would underestimate the toxicological risk to organisms in this aquatic ecosystem. It appears necessary to develop new WQC for the protection of aquatic organisms in Lake Chaohu. Four grades of priority control chemicals (PCCs) in Lake Chaohu were proposed. The highest priority was assigned to organonitrogen-phosphorus pesticides, including parathion, dichlorvos, malathion, omethoate, and di-n-butyl phthalate. However, the national "blacklist" of toxic compounds only covered 7 of 20 PCCs, indicating that the other 13 PCCs would not be controlled efficiently. Because the pollution pattern of PTSs in various water bodies might be quite different, we appealed to the governments to screen the regional PPC lists or develop a more comprehensive national list for aquatic ecosystem protection in China.

  12. Study of Quality Control Method of Sparfloxacin Ophthalmic Gel%司帕沙星眼用凝胶质量控制方法研究

    Institute of Scientific and Technical Information of China (English)

    温坚; 李芳; 汪德凤; 黄娜; 洪宝贤; 林三清; 夏敬民

    2011-01-01

    Objective To and to establish quality control method of sparfloxacin ophthalmic gel. Methods Carhomer -940 was used as matrix to prepare Sparfloxacin Ophthalmic Gel. The appearance of the gel was observed and the pH value of it was determined by pHS -25C digital acidometer. The content of sparfloxacin in the gel was determined by ultraviolet spectrophotometer at the wavelength of 297 nm. Results Sparfloxacin Ophthalmic Cel was faint yellow colloid and it accorded with relative quality requirement of Chinese Pharmacopoeia( 2005). A linear calibration curve for assay of sparfloxacin was obtained in the range of 2. 04 - 14. 28 μg/mL, r=0. 999 95( n =7 ) and the average recoveries were 99. 48%, RSD =0. 738( n =6 ). Conclusion The quality control method of Sparfloxacin Ophthalmic Gel is feasible, and it is accurate and fast that the content of sparfloxacin in the gel is determined by ultraviolet spectrophotometer.%目的 建立司帕沙星眼用凝胶的质量控制方法.方法 观察以卡波姆-940为基质制备的司帕沙星眼用凝胶的外观性状,用pHS-25C型数字酸度计测定其pH,在297 nm波长处采用紫外分光光度法测定其中主药的含量.结果 所得制剂为淡黄色胶体,凝胶质量符合2010年版中眼用凝胶的质量要求;司帕沙星质量浓度在2.04~14.28μg/mL范围内与吸光度线性关系良好,r=0.999 95(n=7),平均回收率为99.48%,RSD为0.73%(n=6).结论 司帕沙星眼用凝胶的质量控制方法可行,采用紫外分光光度法测定其主药含量准确、快速.

  13. Integrated quality control architecture for multistage machining processes

    Science.gov (United States)

    Yang, Jie; Liu, Guixiong

    2010-12-01

    To solve problems concerning the process quality prediction control for the multistage machining processes, a integrated quality control architecture is proposed in this paper. First, a hierarchical multiple criteria decision model is established for the key process and the weight matrix method stratified is discussed. Predictive control of the manufacturing quality is not just for on-site monitoring and control layer, control layer in the enterprise, remote monitoring level of quality exists a variety of target predictive control demand, therefore, based on XML to achieve a unified description of manufacturing quality information, and in different source of quality information between agencies to achieve the transfer and sharing. This will predict complex global quality control, analysis and diagnosis data to lay a good foundation to achieve a more practical, open and standardized manufacturing quality with higher levels of information integration system.

  14. Evaluation of yield quality and weed infestation of common valerian (Valeriana officinalis L. in dependence on weed control method and forecrop.

    Directory of Open Access Journals (Sweden)

    Cezary Kwiatkowski

    2012-12-01

    Full Text Available A field experiment involving the cultivation of common valerian was conducted on loess soil in Abramów (Lublin region in the period 2007-2009. Qualitative parameters of herbal raw material obtained from this plant as well as in-crop weed infestation were evaluated depending on the protection method and forecrop. Hand-weeded plots, in which a hand hoe was used, were the control. In the other treatments, weeds were controlled using various herbicides and a mechanical implement (brush weeder. Potato and winter wheat + field pea cover crop were the forecrops for common valerian crops. A hypothesis was made that the use of a brush weeder and herbicides not registered for application in valerian crops would have a positive effect on this plant's productivity and weed infestation in its crops. It was also assumed that the introduction of a cover crop would allow the elimination of differences in the forecrop value of the crop stands in question. The best quantitative and qualitative parameters of common valerian raw material as well as the largest reduction of incrop weed infestation were recorded after the application of the herbicides which were not type approved. The use of the brush weeder in the interrows also had a beneficial effect on productivity of the plant in question, but secondary weed infestation at the end of the growing season of common valerian turned out to be its disadvantage. Traditional crop protection methods used in common valerian crops were less effective in weed infestation reduction and they resulted in lower plant productivity and raw material quality. Potato proved to be a better forecrop for common valerian than winter wheat + field pea; however, this positive effect was not confirmed statistically. The following annual weeds: Chenopodium album, Galinsoga parviflora, Stellaria media, were predominant in the common valerian crop. Traditional weed control methods resulted in the dominance of some dicotyledonous weeds, such

  15. A UV-Raman spectrometry method for quality control of anticancer preparations: Results after 18 months of implementation in hospital pharmacy.

    Science.gov (United States)

    Nardella, Flore; Beck, Morgane; Collart-Dutilleul, Pierre; Becker, Guillaume; Boulanger, Coralie; Perello, Laurent; Gairard-Dory, Anne; Gourieux, Bénédicte; Ubeaud-Séquier, Geneviève

    2016-02-29

    In France, chemotherapy preparation units of hospital pharmacy compound cytotoxic infusion bags adapted to each patient. The narrow therapeutic index of these preparations led us to implement qualitative and quantitative control for patients' safety. To this aim, we calibrated an equipment combining UV-vis spectrometry and Raman spectroscopy (QC Prep+) and monitored 14 different molecule-solvent combinations over a 18 months period. This rapid and specific method allowed the qualitative and quantitative analysis of 1 mL sample tests in less than 2 min. On 5742 anticancer preparations, we obtained accepted results with more than 99.4% solvent identification, 99.6% drug identification and only 1.52% of preparations not matching quantitative specifications (±15% of theoretical concentration). This quantitative control enabled us to pinpoint some critical points of production for two of the most common preparations. We thus updated the procedures of reconstitution and preparation, increasing the quality of final product. UV-Raman spectrometry is thus an effective tool to control chemotherapy infusions and to improve good practices of preparation. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. Quality Control and Testing Methods of Infusion Apparatus%输液设备的质量控制和检测方法

    Institute of Scientific and Technical Information of China (English)

    侯明扬

    2014-01-01

    根据输液设备质量检测规范,利用FULK测量设备分别对输液泵和注射泵的外观、流量、阻塞报警压力阈值、监测与报警系统进行检测,并对各个参数的检测方法与标准做了详细介绍,为医学工程人员进行输液设备的质控工作提供参考。%According to the quality inspection speciifcations of infusion apparatus, the appearance, lfow, pressure threshold value of blocking alarm and monitoring and alarm system of infusion pump and injection pump were tested by using FULK measuring equipment. This paper also introduced the testing methods and standards of various parameters in order to provide reference information for medical engineering staff to improve the quality control of infusion apparatus.

  17. Internal quality control: best practice.

    Science.gov (United States)

    Kinns, Helen; Pitkin, Sarah; Housley, David; Freedman, Danielle B

    2013-12-01

    There is a wide variation in laboratory practice with regard to implementation and review of internal quality control (IQC). A poor approach can lead to a spectrum of scenarios from validation of incorrect patient results to over investigation of falsely rejected analytical runs. This article will provide a practical approach for the routine clinical biochemistry laboratory to introduce an efficient quality control system that will optimise error detection and reduce the rate of false rejection. Each stage of the IQC system is considered, from selection of IQC material to selection of IQC rules, and finally the appropriate action to follow when a rejection signal has been obtained. The main objective of IQC is to ensure day-to-day consistency of an analytical process and thus help to determine whether patient results are reliable enough to be released. The required quality and assay performance varies between analytes as does the definition of a clinically significant error. Unfortunately many laboratories currently decide what is clinically significant at the troubleshooting stage. Assay-specific IQC systems will reduce the number of inappropriate sample-run rejections compared with the blanket use of one IQC rule. In practice, only three or four different IQC rules are required for the whole of the routine biochemistry repertoire as assays are assigned into groups based on performance. The tools to categorise performance and assign IQC rules based on that performance are presented. Although significant investment of time and education is required prior to implementation, laboratories have shown that such systems achieve considerable reductions in cost and labour.

  18. 深层搅拌法施工特点和质量控制%Construction Characteristics and Quality Control of Deep Mixing Method

    Institute of Scientific and Technical Information of China (English)

    王亚莉; 孔祥亮; 李保红

    2016-01-01

    From steps of construction technology, the applicable conditions, technique flow, construction preparation, construction technolo-gy and quality control of the deep mixing method are introduced.Features of the method such as high efficiency, low cost and reliable per-formance, etc are described.In the engineering construction, the method is with outstanding benefit and prospect of wide application in the construction fields of water resources and hydropower engineering.%从施工工艺的各个环节介绍深层搅拌法的适用条件、工艺流程、施工准备、施工工艺及质量检验控制环节,阐明深层搅拌法具有工效高、造价低、性能可靠等优点,在工程建设方面发挥显著的效益,在水利水电工程建设领域具有广泛应用的前景。

  19. Development and validation of a stability-indicating gas chromatographic method for quality control of residual solvents in blonanserin: a novel atypical antipsychotic agent.

    Science.gov (United States)

    Peng, Ming; Liu, Jin; Lu, Dan; Yang, Yong-Jian

    2012-09-01

    Blonanserin is a novel atypical antipsychotic agent for the treatment of schizophrenia. Ethyl alcohol, isopropyl alcohol and toluene are utilized in the synthesis route of this bulk drug. A new validated gas chromatographic (GC) method for the simultaneous determination of residual solvents in blonanserin is described in this paper. Blonanserin was dissolved in N, N-dimethylformamide to make a sample solution that was directly injected into a DB-624 column. A postrun oven temperature at 240°C for approximately 2 h after the analysis cycle was performed to wash out blonanserin residue in the GC column. Quantitation was performed by external standard analyses and the validation was carried out according to International Conference on Harmonization validation guidelines Q2A and Q2B. The method was shown to be specific (no interference in the blank solution), linear (correlation coefficients ≥0.99998, n = 10), accurate (average recoveries between 94.1 and 101.7%), precise (intra-day and inter-day precision ≤2.6%), sensitive (limit of detection ≤0.2 ng, and limit of quantitation ≤0.7 ng), robust (small variations of carrier gas flow, initial oven temperature, temperature ramping rate, injector and detector temperatures did not significantly affect the system suitability test parameters and peak areas) and stable (reference standard and sample solutions were stable over 48 h). This extensively validated method is ready to be used for the quality control of blonanserin.

  20. Improvement of Argo salinity data delayed-mode quality control method%Argo盐度资料延时质量控制的改进方法

    Institute of Scientific and Technical Information of China (English)

    卢少磊; 李宏; 刘增宏

    2014-01-01

    针对现有Argo盐度资料延时质量控制方法( OW方法)在时空尺度参数与最优压力层选取方面的不足,在气候态盐度剖面客观估计过程中引入梯度依赖空间尺度法,以及在最优压力层的选取中提出一个利用气候态盐度资料代替浮标原始盐度观测资料的优化方案,构建了一个改进的Argo盐度资料延时质量控制方法。采用理论和现场观测资料检验等手段,对梯度依赖空间尺度法在资料客观估计中的可行性,以及优化方案对选取最优压力层的合理性做了验证。结果表明,梯度依赖空间尺度法在温盐梯度较大海域,可以将15 MP a水深以上的盐度估计精度提高0.01以上,而利用气候态盐度客观估计结果选取最优压力层的优化方案,能够更合理地选取最优压力层。%To solve the deficiencies of the spatial scale and the best pressure levels in the existing Argo salinity de-layed-mode quality control method( OW method) , a Gradient-Dependent Spatial Scale Method ( GDSSM) was in-troduced in objective estimation of climatological salinity at locations of the float profiles, an optimization scheme proposed in which climatological salinity is used instead of observations from the float, and an improved Argo salini-ty delayed-mode quality control method set up. Using the means of theory testing and field observation data testing, the feasibility of the GDSSM and the rationality of the optimization scheme were verified. The results show that, in the sea area where the sea-water temperature and salinity is large changes, the GDSSM can improve the accuracy a-bout 0. 01 in above 150 bar depth, and that the optimization scheme can get more reasonable result of the best pres-sure levels.

  1. Application of Urine Dry Chemistry Method for CLIS Control Management Software in Internal Quality Control%CLIS质控管理软件在尿液干化学法室内质控中的应用

    Institute of Scientific and Technical Information of China (English)

    景娟; 牛洁; 陈鑫; 刘亚东; 孙斌

    2013-01-01

    目的 应用CLIS质控管理软件进行尿干化学法室内质控.方法 根据每个批次质控品的参考范围建立实验室的均值和标准差.质控品在Uritest-500型尿干化学分析仪进行尿11项测试,除尿液比重、pH外,其它定性测定项目结果定义为:0代表阴性,0.5代表±,1代表1+,2 代表2+,3代表3+,4代表4+.定性数值以阳性数值均值的系数为均值,标准差根据阳性级别取1或0.5输入CLIS质控管理软件.任意一个试剂模块的测定结果与质控尿液期望"靶值"允许有一个等级的差异,超过此范围或结果在"正常和异常"之间跳跃均应视为失控.结果 CLIS质控管理软件将尿液干化学定性结果数量化,可直观反映每日的室内质控结果.结论 该方法操作简单,提高了检验科工作效率,有较强的实用性和可行性,是一个有效的质控图绘制方法.%Objective To apply CLIS quality control management software to carry on the urine dry chemistry method of internal quality control.Methods Established the lab reference range of mean and standard deviation according to each batch quality products.Quality products in Uritest-500 type tested urine 11 items of urine dry chemical analyzer.Except for the u-rine specific gravity,pH,other qualitative determination of project results were defined as 0 represents negative,0.5 repre-sents±,1 represents 1±,2 represents 2±,3 represents 3± and 4 represents 4±.Qualitative with positive values was the coefficient of mean and standard deviation was input level 1,or 0.5 to CLIS quality management software according to the positive.Any measurement results and quality control of urine reagent module expectations,"target value" was allowed for a level difference,more than the range,or the results between the normal and abnormal jump should be regarded as out of control.Results CLIS quality management software made urine dry chemical qualitative results quantification, and could intuitively reflect the

  2. 33 CFR 385.21 - Quality control.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Quality control. 385.21 Section... Processes § 385.21 Quality control. (a) The Corps of Engineers and the non-Federal sponsor shall prepare a quality control plan, in accordance with applicable Corps of Engineers regulations, for each product...

  3. 7 CFR 930.44 - Quality control.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Quality control. 930.44 Section 930.44 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Control § 930.44 Quality control. (a) Quality standards. The Board may establish, with the approval of...

  4. 7 CFR 981.42 - Quality control.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Quality control. 981.42 Section 981.42 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Quality Control § 981.42 Quality control. (a) Incoming. Except as provided in...

  5. 14 CFR 21.139 - Quality control.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Quality control. 21.139 Section 21.139... PROCEDURES FOR PRODUCTS AND PARTS Production Certificates § 21.139 Quality control. The applicant must show that he has established and can maintain a quality control system for any product, for which...

  6. Size-exclusion HPLC provides a simple, rapid, and versatile alternative method for quality control of vaccines by characterizing the assembly of antigens.

    Science.gov (United States)

    Yang, Yanli; Li, Hao; Li, Zhengjun; Zhang, Yan; Zhang, Songping; Chen, Yi; Yu, Mengran; Ma, Guanghui; Su, Zhiguo

    2015-02-25

    The assembly of antigen structure is often crucial to the potency of vaccines. Currently adopted methods like animal testing and ultracentrifugation take long time and are difficult to automate for multiple samples. Here we develop a size-exclusion high-performance liquid chromatography (SE-HPLC) method to characterize the assembly of antigen structure during both manufacturing process and storage. Three important vaccine antigens including inactivated foot and mouth disease virus (FMDV), which is a virus vaccine; and two virus-like particles (VLPs) vaccines involving hepatitis B core antigen (HBcAg) VLPs, and hepatitis B surface antigen (HBsAg) VLPs, were successfully analyzed using commercially available TSK gel columns with pore size above 45nm. Combined with other analytical methods including SDS-PAGE, dynamic light scattering, wavelength scan, and multi-angle laser light scattering, the SE-HPLC method was proven to be a simple, rapid, and reliable tool for antigen particles assembly analysis. Specifically, for FMDV whole virus particle, SE-HPLC was used to analyze 146S content in vaccine preparations and the thermal dissociation of the 146S. For HBcAg-VLPs that are expressed in recombinant Escherichia coli, its expression level during cell culture process was quantitatively monitored by SE-HPLC. The SE-HPLC also showed applicability for quality check of HBsAg vaccine preparations by monitoring the product consistency of different lot number and the product stability during storage. Results shown in this work clearly demonstrated that SE-HPLC method has potential as a versatile alternative technology for control of the final product by both manufacturers and the regulatory agencies.

  7. Association between product quality control and process quality control of bulk milk

    NARCIS (Netherlands)

    Velthuis, A.; Asseldonk, van M.A.P.M.

    2010-01-01

    Assessment of dairy-milk quality is based on product quality control (testing bulk-milk samples) and process quality control (auditing dairy farms). It is unknown whether process control improves product quality. To quantify possible association between product control and process control a statisti

  8. Quality Control and Reference Guidelines for CLSI Broth Microdilution Susceptibility Method (M38-A Document) for Amphotericin B, Itraconazole, Posaconazole, and Voriconazole

    Science.gov (United States)

    Espinel-Ingroff, A.; Fothergill, A.; Ghannoum, M.; Manavathu, E.; Ostrosky-Zeichner, L.; Pfaller, M.; Rinaldi, M.; Schell, W.; Walsh, T.

    2005-01-01

    Although standard conditions are available for testing the susceptibilities of filamentous fungi to antifungal agents by the Clinical and Laboratory Standards Institute (CLSI; formerly National Committee for Clinical Laboratory Standards) broth microdilution assay, quality control (QC) MIC limits have not been established for any mold-agent combination. This multicenter (eight-center) study documented the reproducibility of tests for one isolate of Paecilomyces variotii ATCC MYA-3630 and 11 other mold isolates (three isolates of Aspergillus fumigatus; two isolates of A. terreus; one isolate each of A. flavus, A. nidulans, Fusarium moniliforme, and F. solani; and two isolates of Scedosporium apiospermum) by the CLSI reference broth microdilution method (M38-A document). Control limits (amphotericin B, 1 to 4 μg/ml; itraconazole, 0.06 to 0.5 μg/ml; posaconazole, 0.03 to 0.25 μg/ml; voriconazole, 0.015 to 0.12 μg/ml) for the selected QC P. variotii ATCC MYA-3630 were established by the analysis of replicate MIC results. Reference isolates and corresponding MIC ranges were also established for 6 of the 12 molds evaluated. MIC limits were not proposed for the other five molds tested due to low testing reproducibility for these isolates. PMID:16207990

  9. Concrete and steel construction quality control and assurance

    CERN Document Server

    El-Reedy, Mohamed A

    2014-01-01

    Starting with the receipt of materials and continuing all the way through to the final completion of the construction phase, Concrete and Steel Construction: Quality Control and Assurance examines all the quality control and assurance methods involving reinforced concrete and steel structures. This book explores the proper ways to achieve high-quality construction projects, and also provides a strong theoretical and practical background. It introduces information on quality techniques and quality management, and covers the principles of quality control. The book presents all of the quality control and assurance protocols and non-destructive test methods necessary for concrete and steel construction projects, including steel materials, welding and mixing, and testing. It covers welding terminology and procedures, and discusses welding standards and procedures during the fabrication process, as well as the welding codes. It also considers the total quality management system based on ISO 9001, and utilizes numer...

  10. Validation of an analytical method for quality control of residual solvents (n-hexane and acetone) in D-002: new active ingredient from beeswax.

    Science.gov (United States)

    Antolín, Ernesto Méndez; Quiñónez, Yaisme Balcinde; Canavaciolo, Víctor González; Cruz, Esperanza Rodríguez

    2008-07-15

    D-002 is a new natural product consisting of a mixture of aliphatic fatty alcohols, which shows antioxidant and anti-ulcer effects in experimental models. A new validated methodology for determining simultaneously residual n-hexane and acetone in D-002 using the headspace gas chromatography (HS/GC) is described. The very poor solubility of D-002 in most solvents did necessary sample preparations in solid state. Limit test conditions allowed a detection of residual n-hexane and acetone more sensitively than that recommended for such purposes in the general method of the European Pharmacopoeia. Validation assays, applied to both D-002 residual solvents, proved: suitable sensitivity; very high linearity (correlation coefficients > or =0.999, R.S.D. of slopes < or =0.8% and R.S.D. of response factors < or =5% and no biases) and accuracy (average recoveries between 94.7 and 100.1%); and precision was < or =2.1%. The method was found suitable for quality control and stability studies of this new product.

  11. Quality Control of EUVE Databases

    Science.gov (United States)

    John, Linda M.

    1993-01-01

    The publicly accessible databases for the Extreme Ultraviolet Explorer (EUVE) include: the EUVE Archive Mailserver, the Center for EUV Astrophysics ftp site, the EUVE Guest Observer Mailserver, and the Astronomical Data System node. The EUVE Performance Assurance team is responsible for verifying that these public databases are working properly and that the public availability of EUVE data contained therein does not infringe any data rights which may have been assigned. In this paper, we describe the quality assurance (QA) procedures we have developed from approaching QA as a service organization; this approach reflects the overall EUVE philosophy of QA integrated into normal operating procedures, rather than imposed as an external, post-facto, control mechanism.

  12. AGILE METHODS AND QUALITY _ A SURVEY

    Directory of Open Access Journals (Sweden)

    BODJE N'Kauh Nathan-Regis

    2013-12-01

    Full Text Available Agile software processes, such as extreme programming (XP, Scrum, Lean, etc., rely on best practices that are considered to improve software development quality. It can be said that best practices aim to induce software quality assurance (SQA into the project at hand. Some researchers of agile methods claim that because of the very nature of such methods, quality in agile software projects should be a natural outcome of the applied method. As a consequence, agile quality is expected to be more or less embedded in the agile software processes. Many reports support and evangelize the advantages of agile methods with respect to quality assurance, Is it so ? An ambitious goal of this paper is to present work done to understand how quality is or should be handled. This paper as all survey papers attempt to summarize and organizes research results in the field of software engineering, precisely for the topic of agile methods related to software quality.

  13. Application of Six Sigma Quality Management method in Quality Control of Clinical Chemistry Laboratory%6σ质量标准在临床生化检验室内质量控制中的应用研究

    Institute of Scientific and Technical Information of China (English)

    刘忠民; 高月亭; 肖洪广; 刘利东; 伍众文

    2010-01-01

    目的 应用6σ质量标准分析临床生化检验质量控制数据,评价检验项目质量水平,改进检验质量.方法 收集2007年度临床生化检验项目室内质量控制及室间质量评价数据;按照美国临床实验室改进修正法案中允许总误差(Tea)标准.采用公式σ=(Tea-bias)/CV,计算各检验项目的σ值,绘制6σ性能决定图,评价分析性能,并设计质量控制方案.结果 28个临床生化常规检验项目中,检验项目总分析性能σ≥6、5、4和3者.分别占25%、35.7%、57.1%和71.4%,所有检验项目的平均σ=4.77;当σ≥5时,采用l_(3S)(n=2)质量控制规则能满足质量要求.结论 6σ质量标准的应用.有助于提高临床生化检验质量水平,6σ管理是一项有效的质量管理工具.%Objective To assess and improve the performance of clinical chemistry laboratory by applying the six sigma(6σ)quality management criterion. Methods Data were collected from routine internal quality control and external quality assessment inclinical chemistry laboratory during 2007. Allowable analytical error was defined according to the Clinical Laboratory ImprovementAmendments. The sigma value was calculated according the equation σ= (TEa-bias)/Coefficient of variation (CV),and 6σ decisionchart was made. The quality control strategy based on 6σ was also designed and used for evaluation of the clinical chemical tests. Re-sults 25%.35. 71%,57. 1% and 71.4% of all 28 tests were over 6,5,4 and 3 sigma metrics respectively with the averaged 4. 77.The results met the requirement with the rule of _(13S)(n=2) when the s metric values have been over 5. 0. Conclusion Six Sigmamethodology is an effective tool for quality management in clinical chemistry laboratory.

  14. Quality Control Method of Precipitation Monitoring in Atmospheric Environment%大气环境降水监测的质量控制方法

    Institute of Scientific and Technical Information of China (English)

    孙娟; 喻义勇; 柏松; 朱志锋

    2016-01-01

    根据《环境监测质量管理规定》、《江苏省环境监测质量管理实施细则》及环境监测技术规范的要求,探讨了降水监测采样、样品保存技术、实验室分析的质量控制方法。采用不同采样方法、不同采样器同时采集15场降水,其降雨量、电导率、pH值的比对监测结果合格率均大于90%。经试验,降水各组分有效保存时间不同,其中NO3–, NH4+为3 d;F–,Cl–,SO42–为14 d;K+,Na+,Ca2+,Mg2+为30 d。选择2家实验室对降水样品、空白样品、标准样品同时测试,结果显示,空白测定结果均低于方法检出限,标准曲线相关性系数r≥0.9990,测定结果的相对标准偏差为1.4%~5.9%(n=6),加标回收率为89.8%~106%,标准样品的分析结果均合格。该方法能保证降水监测结果准确、可靠,满足HJ/T 165–2004《酸沉降监测技术规范》的要求。%The quality control methods of precipitation monitoring sampling,sample preservationand laboratory analysis were discussed according to the environment monitoring technical specification and standard methods such as Environmental Monitoring Quality Management Regulations and Jiangsu Province Environmental Monitoring Quality Management Implementation Details. The qualified rate of detection of rainfall,conductivity and pH monitoring was higher than 90% in 15 precipitation samples by different sampling methods and equipments. The experimental results showed that the retention time were 3 d for nitrate and ammonium,14 d forfluoride,chloride and sulfate ions,30 d for the potassium, sodium,calcium and magnesium in precipitation sample. The comparison experiment was carried out in two laboratories. The blanks were below the method detection limits,standard curve correlation coefficients were not less than 0.999 0. The relative standard deviations of detection results were 1.4%–5.9% (n=6), the recoveries of the target were 89.8%–106%. The

  15. Reliability of nucleic acid amplification methods for detection of Chlamydia trachomatis in urine: results of the first international collaborative quality control study among 96 laboratories

    NARCIS (Netherlands)

    R.P.A.J. Verkooyen (Roel); G.T. Noordhoek; P.E. Klapper; J. Reid; J. Schirm; G.M. Cleator; M. Ieven; G. Hoddevik

    2003-01-01

    textabstractThe first European Quality Control Concerted Action study was organized to assess the ability of laboratories to detect Chlamydia trachomatis in a panel of urine samples by nucleic acid amplification tests (NATs). The panel consisted of lyophilized urine samples, includ

  16. Developing a TQM quality management method model

    NARCIS (Netherlands)

    Zhang, Zhihai

    1997-01-01

    From an extensive review of total quality management literature, the external and internal environment affecting an organization's quality performance and the eleven primary elements of TQM are identified. Based on the primary TQM elements, a TQM quality management method model is developed. This mo

  17. Developing a TQM quality management method model

    NARCIS (Netherlands)

    Zhang, Zhihai

    1997-01-01

    From an extensive review of total quality management literature, the external and internal environment affecting an organization's quality performance and the eleven primary elements of TQM are identified. Based on the primary TQM elements, a TQM quality management method model is developed. This mo

  18. Developing a TQM quality management method model

    NARCIS (Netherlands)

    Zhang, Zhihai

    1997-01-01

    From an extensive review of total quality management literature, the external and internal environment affecting an organization's quality performance and the eleven primary elements of TQM are identified. Based on the primary TQM elements, a TQM quality management method model is developed. This

  19. A review of decellurization methods caused by an urgent need for quality control of cell-free extracellular matrix' scaffolds and their role in regenerative medicine.

    Science.gov (United States)

    Kawecki, Marek; Łabuś, Wojciech; Klama-Baryla, Agnieszka; Kitala, Diana; Kraut, Malgorzata; Glik, Justyna; Misiuga, Marcelina; Nowak, Mariusz; Bielecki, Tomasz; Kasperczyk, Aleksandra

    2017-02-14

    The natural extracellular matrix (ECM),thanks to its specific properties (e.g., collagenous lattice, a reservoir of growth factors, ECM-cell anchoring areas, an optimal pH and CO2 ),ensures an optimal microenvironment for homeostatic and regenerative cell development. In the context of regenerative medicine, ECM is a lair for residual and infiltrative cells. The aim of the clinical usage of cell-free ECM scaffolds is the enhancement of tissue regeneration with possible minimization of an adverse host reaction on allogeneic or xenogeneic biomaterial. Thus, the objective of decellularization is to obtain acellular grafts characterized by optimal biological properties, such as a lack of remaining cellular elements (e.g., cell membrane phospholipids and proteins, nucleic acids, mitochondria), lack of immunogenicity, lack of calcification promotion and lack of cytotoxicity (e.g., in unrinsed detergents). Furthermore, cell-free ECM scaffolds should present the optimal mechanical and structural properties that may ensure the biocompatibility of the graft. The maintenance of the ultrastructure composition of the ECM is one of the most important goals of decellularization. All physical, chemical, and biological methods proposed (used separately or in combination to extract cells from tissues/organs) are not 100% effective in cell removal and always cause a disruption of the ECM texture, as well as a probable loss of important structure components. Although cell-free ECM scaffolds are generally classified as medical devices, there are no widely accepted or legally defined criteria for quality control/evaluation methods of obtained matrices. Such criteria must be provided. Some of them have been proposed in this manuscript. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2017. © 2017 Wiley Periodicals, Inc.

  20. Information Quality Control of ERP System

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    From the viewpoint of manufacturing enterprises, th is thesis discusses the concept and definition of information quality as well as t he connotation of information quality. Based on our personal experiences of many years, we have summarized the cases of success and failure with ERP system, an d from the angle of information quality control, we have come up with the follow ing concepts : static information quality of enterprises, information maturity o f enterprises and dynamic information quality.Inform...

  1. Study on determination method of quality control for Siweikanglao pills%四味抗痨丸质量标准研究

    Institute of Scientific and Technical Information of China (English)

    邱远金; 朱国强; 力瓦衣丁·买合苏提; 贾晓光; 陈书强; 李忠民

    2012-01-01

    目的:建立四味抗痨丸的质量控制标准.方法:利用薄层色谱法对四味抗痨丸处方中的白芍、大黄、巴豆进行定性鉴别;采用高效液相色谱法测定四味抗痨丸中芍药苷的含量.色谱条件:以十八烷基硅烷键合硅胶为填充剂;以乙腈-0.1%磷酸溶液(14:86)为流动相;检测波长为230nm;柱温30℃;流速为1.0mL·min-1;进样量为10μL.结果:白芍、大黄、巴豆采用相应的薄层鉴别方法,薄层展开后均显示与对照药材相同的特异性斑点,分离效果好.芍药苷质量在2.55×10-3g~0.51μg范围内与峰面积有良好的线性关系.平均回收率为97.5%,RSD为0.57%.结论:该方法准确、可靠、专属性强,为建立四味抗痨丸质量控制标准提供依据.%Objective:To establish a quality standard of Siweikanglao pills. Method:Traditional Chinese medicine in prescription such as herbal Paeonia lactiflora Pall.Rheum officinale Bail]. Croton tiglium L were identified by a series of TLC methods. The content of paeoniforin in Siweikanglao pills was determined by HPLC method. Phenome- nex column was adopted with the mobile phase consisted of acetonitrile-0. 1 % phosphoric acid (14:86) at flow rate of 1.0 mL o min-1, the UV detection wavelength was 230 run, and the volume of injection was 10 μL. Results:Three methods were established for the identification of Paeonia lactiflora Pall. Rheum officinale Baill. Croton tiglium L with TLC. The principal spot in the chromatogram obtained with the test solution was similar in position, colour and size to the principal spot in the chromatogram obtained with the reference solution. The linear range of staehydrine hydrochloride was within the range of 2.55 ×10 -3 -0.51 μg. The average recovery was 97. 5% and the RSD was 0. 57%. Conclusion:The method is accurate, reliable and specific ,and can be used for the quality control of Siweikanglao pills.

  2. Numerical methods in control

    Science.gov (United States)

    Mehrmann, Volker; Xu, Hongguo

    2000-11-01

    We study classical control problems like pole assignment, stabilization, linear quadratic control and H[infinity] control from a numerical analysis point of view. We present several examples that show the difficulties with classical approaches and suggest reformulations of the problems in a more general framework. We also discuss some new algorithmic approaches.

  3. Distributed Sensor Architecture for Intelligent Control that Supports Quality of Control and Quality of Service

    Directory of Open Access Journals (Sweden)

    Jose-Luis Poza-Lujan

    2015-02-01

    Full Text Available This paper is part of a study of intelligent architectures for distributed control and communications systems. The study focuses on optimizing control systems by evaluating the performance of middleware through quality of service (QoS parameters and the optimization of control using Quality of Control (QoC parameters. The main aim of this work is to study, design, develop, and evaluate a distributed control architecture based on the Data-Distribution Service for Real-Time Systems (DDS communication standard as proposed by the Object Management Group (OMG. As a result of the study, an architecture called Frame-Sensor-Adapter to Control (FSACtrl has been developed. FSACtrl provides a model to implement an intelligent distributed Event-Based Control (EBC system with support to measure QoS and QoC parameters. The novelty consists of using, simultaneously, the measured QoS and QoC parameters to make decisions about the control action with a new method called Event Based Quality Integral Cycle. To validate the architecture, the first five Braitenberg vehicles have been implemented using the FSACtrl architecture. The experimental outcomes, demonstrate the convenience of using jointly QoS and QoC parameters in distributed control systems.

  4. Distributed Sensor Architecture for Intelligent Control that Supports Quality of Control and Quality of Service

    Science.gov (United States)

    Poza-Lujan, Jose-Luis; Posadas-Yagüe, Juan-Luis; Simó-Ten, José-Enrique; Simarro, Raúl; Benet, Ginés

    2015-01-01

    This paper is part of a study of intelligent architectures for distributed control and communications systems. The study focuses on optimizing control systems by evaluating the performance of middleware through quality of service (QoS) parameters and the optimization of control using Quality of Control (QoC) parameters. The main aim of this work is to study, design, develop, and evaluate a distributed control architecture based on the Data-Distribution Service for Real-Time Systems (DDS) communication standard as proposed by the Object Management Group (OMG). As a result of the study, an architecture called Frame-Sensor-Adapter to Control (FSACtrl) has been developed. FSACtrl provides a model to implement an intelligent distributed Event-Based Control (EBC) system with support to measure QoS and QoC parameters. The novelty consists of using, simultaneously, the measured QoS and QoC parameters to make decisions about the control action with a new method called Event Based Quality Integral Cycle. To validate the architecture, the first five Braitenberg vehicles have been implemented using the FSACtrl architecture. The experimental outcomes, demonstrate the convenience of using jointly QoS and QoC parameters in distributed control systems. PMID:25723145

  5. Methods in Logic Based Control

    DEFF Research Database (Denmark)

    Christensen, Georg Kronborg

    1999-01-01

    Desing and theory of Logic Based Control systems.Boolean Algebra, Karnaugh Map, Quine McClusky's algorithm. Sequential control design. Logic Based Control Method, Cascade Control Method. Implementation techniques: relay, pneumatic, TTL/CMOS,PAL and PLC- and Soft_PLC implementation. PLC-design met......Desing and theory of Logic Based Control systems.Boolean Algebra, Karnaugh Map, Quine McClusky's algorithm. Sequential control design. Logic Based Control Method, Cascade Control Method. Implementation techniques: relay, pneumatic, TTL/CMOS,PAL and PLC- and Soft_PLC implementation. PLC...

  6. Shipping/Receiving and Quality Control

    Data.gov (United States)

    Federal Laboratory Consortium — Shipping receiving, quality control, large and precise inspection and CMM machines. Coordinate Measuring Machines, including "scanning" probes, optical comparators,...

  7. Establishment for quality control of experimental animal

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Hwan; Kim, Soo Kwan; Kim, Tae Kyoung

    1999-06-01

    Until now, because we have imported experimental animal from foreign experimental animal corporation, we could have saved money by establishing the quality control of animal in barrier system. In order to improve the quality of animal experiment and efficiency of biomedical study, it is indispensable to control many factors that effect in the experiment. Therefore, it is essential to organize the system of laboratory animal care for enhancing reliability and revivability of experimental results. The purpose of the present investigation was to establish the quality control system of experimental animals that we can provide good quality animals according to the experimental condition of each investigator although the exact quality control system to estimate the infection of bacteria and virus easily remains ill-defined yet. Accordingly, we established the useful quality control system for microbiologic monitoring and environmental monitoring to protect experimental animal from harmful bacteria and virus.

  8. Birth control - slow release methods

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/article/007555.htm Birth control - slow release methods To use the sharing features on this page, please enable JavaScript. Certain birth control methods contain man-made forms of hormones. These ...

  9. Colorado Air Quality Control Regulations and Ambient Air Quality Standards.

    Science.gov (United States)

    Colorado State Dept. of Health, Denver. Div. of Air Pollution Control.

    Regulations and standards relative to air quality control in Colorado are defined in this publication. Presented first are definitions of terms, a statement of intent, and general provisions applicable to all emission control regulations adopted by the Colorado Air Pollution Control Commission. Following this, three regulations are enumerated: (1)…

  10. Fuzzy Design Method of Product Quality Robustness

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    In order to express information on the quality grade of product, designed, the target value of product quality design was described with a fuzzy number in this paper. The rule of robust design with a fuzzy target was analyzed with fuzzy probability theory,then the principle and modeling method of fuzzy robust design for a high quality product were put forward. With this new method used, the high-quality ratio of the product de-signed could be increased, and the ability to resist the influence of various disturbing fac-tors ang noise factors could be enhanced.

  11. Association between product quality control and process quality control of bulk milk

    OpenAIRE

    Velthuis, A.; Asseldonk, van, M.M.L.

    2010-01-01

    Assessment of dairy-milk quality is based on product quality control (testing bulk-milk samples) and process quality control (auditing dairy farms). It is unknown whether process control improves product quality. To quantify possible association between product control and process control a statistical analysis was conducted. The analysis comprised 64.373 audit results on 26,953 dairy farms and all conducted lab tests of bulk-milk samples two, six or 12 months before the audit. Lab results in...

  12. Rapid methods : for food and feed quality determination

    NARCIS (Netherlands)

    Amerongen, van A.; Barug, D.; Lauwaars, M.

    2007-01-01

    There is an ever-increasing need for rapid methods and instrumentation in the field of food and feed quality. Key issues dealt with in the food and feed industry include: monitoring of processes at all stages; showing due diligence in the control of food and nutritional quality; achieving rapid

  13. Rapid methods : for food and feed quality determination

    NARCIS (Netherlands)

    Amerongen, van A.; Barug, D.; Lauwaars, M.

    2007-01-01

    There is an ever-increasing need for rapid methods and instrumentation in the field of food and feed quality. Key issues dealt with in the food and feed industry include: monitoring of processes at all stages; showing due diligence in the control of food and nutritional quality; achieving rapid resu

  14. Sparsity Methods for Networked Control

    OpenAIRE

    Nagahara, Masaaki

    2014-01-01

    In this presentation, we introduce sparsity methods for networked control systems and show the effectiveness of sparse control. In networked control, efficient data transmission is important since transmission delay and error can critically deteriorate the stability and performance. We will show that this problem is solved by sparse control designed by recent sparse optimization methods.

  15. Methods in Logic Based Control

    DEFF Research Database (Denmark)

    Christensen, Georg Kronborg

    1999-01-01

    Desing and theory of Logic Based Control systems.Boolean Algebra, Karnaugh Map, Quine McClusky's algorithm. Sequential control design. Logic Based Control Method, Cascade Control Method. Implementation techniques: relay, pneumatic, TTL/CMOS,PAL and PLC- and Soft_PLC implementation. PLC...

  16. Quality control education in the community college

    Science.gov (United States)

    Greene, J. Griffen; Wilson, Steve

    1966-01-01

    This paper describes the Quality Control Program at Daytona Beach Junior College, including course descriptions. The program in quality control required communication between the college and the American Society for Quality Control (ASQC). The college has machinery established for certification of the learning process, and the society has the source of teachers who are competent in the technical field and who are the employers of the educational products. The associate degree for quality control does not have a fixed program, which can serve all needs, any more than all engineering degrees have identical programs. The main ideas which would be common to all quality control programs are the concept of economic control of a repetitive process and the concept of developing individual potentialities into individuals who are needed and productive.

  17. Multistep method for controlling chaos

    Science.gov (United States)

    Starobinets, Igor M.; Pikovsky, Arkady S.

    1993-10-01

    We present a multistep control method where the trajectory on a chaotic attractor is directed by small perturbations towards a chosen fixed point. The method gives a significant reduction of the chaotic transient preceding the controlled motion as compared with the Ott-Grebogi-Yorke method. Transition from local to global control, when chaotic transients disappear, is discussed.

  18. Handling qualities requirements for control configured vehicles

    Science.gov (United States)

    Woodcock, R. J.; George, F. L.

    1976-01-01

    The potential effects of fly by wire and control configured vehicle concepts on flying qualities are considered. Failure mode probabilities and consequences, controllability, and dynamics of highly augmented aircraft are among the factors discussed in terms of design criteria.

  19. Employee quality, monitoring environment and internal control

    Directory of Open Access Journals (Sweden)

    Chunli Liu

    2017-03-01

    Full Text Available We investigate the effect of internal control employees (ICEs on internal control quality. Using special survey data from Chinese listed firms, we find that ICE quality has a significant positive influence on internal control quality. We examine the effect of monitoring on this result and find that the effect is more pronounced for firms with strict monitoring environments, especially when the firms implement the Chinese internal control regulation system (CSOX, have higher institutional ownership or attach greater importance to internal control. Our findings suggest that ICEs play an important role in the design and implementation of internal control systems. Our study should be of interest to both top managers who wish to improve corporate internal control quality and regulators who wish to understand the mechanisms of internal control monitoring.

  20. Escolha de um programa de controle da qualidade da água para consumo humano: aplicação do Método AHP Selection of water quality control program for human consumption: application of the AHP Method

    Directory of Open Access Journals (Sweden)

    Lucijane Monteiro de Abreu

    2000-01-01

    Full Text Available Este trabalho relata uma aplicação de métodos multicritérios no apoio à tomada de decisão para a escolha de um programa de controle da qualidade da água potável para consumo humano no Brasil. Dentre esses métodos, foi escolhido o AHP (Analytic Hierarchy Process em função de permitir a agregação de informações quantitativas e qualitativas. A possibilidade de tratamento das variáveis qualitativas mostra um avanço nos métodos de análise de decisão, visto que elas introduzem a subjetividade à decisão, por exprimir as preferências e valores dos tomadores de decisão.The present work aims to discuss the use of a multicriteria method in a decision support for choosing a water quality control program for human consumption in Brazil. Among multicriteria methods the AHP (Analitic Hierarchy Process was chosen because this method permits qualitative and quantitative information aggregation. Possibility of qualitative variables treatment shows an evolution in decision analysis systems as it introduces subjectivity in the decision making and express value and preferences of decision makers.

  1. Coastal Erosion Control Methods

    Science.gov (United States)

    Greene, V.

    2016-12-01

    Coastal erosion is bad because the ecosystem there will be washed away and the animals could drown or be displaced and have to adapt to a new ecosystem that they are not prepared for. I'm interested in this problem because if there aren't beaches when I grow up I won't be able to do the things I would really like to do. I would like to be a marine biologist. Secondly, I don't want to see beach houses washed away. I would like to see people live in harmony with their environment. So, to study ways in which to preserve beaches I will make and use models that test different erosion controls. Two different ideas for erosion control I tested are using seaweed or a rock berm. I think the rock berm will work better than the model of seaweed because the seaweed is under water and the waves can carry the sand over the seaweed, and the rock berm will work better because the rocks will help break the waves up before they reach the shore and the waves can not carry the sand over the rocks that are above the water. To investigate this I got a container to use to model the Gulf of Mexico coastline. I performed several test runs using sand and water in the container to mimic the beach and waves from the Gulf of Mexico hitting the shoreline. I did three trials for the control (no erosion control), seaweed and a rock berm. Rock berms are a border of a raised area of rock. The model for seaweed that I used was plastic shopping bags cut into strips and glued to the bottom of my container to mimic seaweed. My results were that the control had the most erosion which ranged from 2.75 - 3 inches over 3 trials. The seaweed was a little better than the control but was very variable and ranged from 1.5 - 3 inches over 3 trials. The rock berm worked the best out of all at controlling erosion with erosion ranging from 1.5 - 2 inches. My hypothesis was correct because the rock berm did best to control erosion compared to the control which had no erosion control and the model with seaweed.

  2. 7 CFR 981.442 - Quality control.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Quality control. 981.442 Section 981.442 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Administrative Rules and Regulations § 981.442 Quality control. (a) Incoming. Pursuant to § 981.42(a),...

  3. 30 CFR 74.6 - Quality control.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality control. 74.6 Section 74.6 Mineral... of the CMDPSU will be maintained in production through adequate quality control procedures, MSHA and... DUST SAMPLING DEVICES Approval Requirements for Coal Mine Dust Personal Sampler Unit § 74.6...

  4. Microbiological methods for assessing soil quality

    NARCIS (Netherlands)

    Bloem, J.; Hopkins, D.W.; Benedetti, A.

    2006-01-01

    This book provides a selection of microbiological methods that are already applied in regional or national soil quality monitoring programs. It is split into two parts: part one gives an overview of approaches to monitoring, evaluating and managing soil quality. Part two provides a selection of meth

  5. Computerized triaxial test control methods

    DEFF Research Database (Denmark)

    Sabaliauskas, Tomas; Ibsen, Lars Bo

    2016-01-01

    capabilities of the setup are extended by using a programmable hydraulic piston with real time feedback loops. The control methods provided by the controller mimic those applied in computer simulations. Force control, displacement control or a combination of both can be used. Single diameter height sample...... control methods provide access to testing both direct and inverse stiffness matrix response as well as to observe strain creep and stress relaxation directly....

  6. Sensometrics for Food Quality Control

    DEFF Research Database (Denmark)

    Brockhoff, Per B.

    2011-01-01

    The industrial development of innovative and succesful food items and the measuring of food quality in general is difficult without actually letting human beings evaluate the products using their senses at some point in the process. The use of humans as measurement instruments calls for special...

  7. Comprehensive quality control method for total flavonoid of Fructus Aurantii%枳壳总黄酮的多指标质量控制

    Institute of Scientific and Technical Information of China (English)

    栾连军; 江周虹; 糜松元; 吴永江

    2011-01-01

    目的:建立枳壳总黄酮多指标质量控制方法.方法:采用高效液相色谱法测定枳壳总黄酮中有效成分含量和指纹图谱,紫外分光光度法测定总黄酮含量.含量测定色谱条件为:Agilent SB-C18色谱柱(4.6 mm ×250 mm,5 μm),流动相为0.02%磷酸水溶液-乙腈(80∶20),流速1 ml/min,柱温35℃,检测波长280 nm.指纹图谱条件为:Agilent SB-C18色谱柱(4.6 mm×250 mm,5μm),流动相A(0.5%醋酸水溶液,V/V)、B(甲醇);梯度洗脱程序(min、B%):0 min、20%,10 min、40%,35 min、70%,50 min、100%;流速1 ml/min,柱温30℃,检测波长320 nm.总黄酮检测波长为283 nm.结果:经方法学认证,含量测定和指纹图谱分析各项参数均符合要求;10批枳壳总黄酮样品的含量分析显示:柚皮苷、新橙皮苷含量为38.3%~47.2%及21.0%~28.5%,总黄酮含量79.9%~88.6%;各批次样品指纹图谱分析都显示12个共有峰,与标准谱图比较,指纹图谱相似度均在98.0%以上.结论:指纹图谱与关键成分含量测定相结合的分析方法能很好地反映枳壳总黄酮整体质量,是一种有效的质量分析与评价方法.该方法测定结果准确,重复性好,可有效控制枳壳总黄酮质量.%Objective: To establish a comprehensive quality control method for total flavonoid of Fructus Aurantii. Methods: RP-HPLC and spectrophotometry were applied for the quantitative and fingerprint analysis of total flavonoid of Fructus Aurantii. The contents of naringin and neohesperidin were determined on an Agilent SB-C18column (4.6 mm × 250 mm,5 μm). The mobile phase was composed of 0.02% H3PO4 and CH3CN(80∶ 20). The flow rate was 1 ml/min with DAD detected at 280 nm. The column temperature was maintained at 35℃. The fingerprints were developed on an Agilent SB-C18 column(4.6 mm ×250 mm,5 μm). The mobile phase was composed of 0.5% HAc and CH3OH with a linear gradient elution. The ratio of 0.5% HAc and CH3OH was: 0 min,80∶20; 10 min,60∶40; 35 min,30

  8. Flying qualities criteria and flight control design

    Science.gov (United States)

    Berry, D. T.

    1981-01-01

    Despite the application of sophisticated design methodology, newly introduced aircraft continue to suffer from basic flying qualities deficiencies. Two recent meetings, the DOD/NASA Workshop on Highly Augmented Aircraft Criteria and the NASA Dryden Flight Research Center/Air Force Flight Test Center/AIAA Pilot Induced Oscillation Workshop, addressed this problem. An overview of these meetings is provided from the point of view of the relationship between flying qualities criteria and flight control system design. Among the items discussed are flying qualities criteria development, the role of simulation, and communication between flying qualities specialists and control system designers.

  9. Analytical techniques and quality control in biomedical trace element research

    DEFF Research Database (Denmark)

    Heydorn, K.

    1994-01-01

    The small number of analytical results in trace element research calls for special methods of quality control. It is shown that when the analytical methods are in statistical control, only small numbers of duplicate or replicate results are needed to ascertain the absence of systematic errors cau...

  10. Chemical control methods and tools

    Science.gov (United States)

    Steven Manning; James. Miller

    2011-01-01

    After determining the best course of action for control of an invasive plant population, it is important to understand the variety of methods available to the integrated pest management professional. A variety of methods are now widely used in managing invasive plants in natural areas, including chemical, mechanical, and cultural control methods. Once the preferred...

  11. Advances in Adaptive Control Methods

    Science.gov (United States)

    Nguyen, Nhan

    2009-01-01

    This poster presentation describes recent advances in adaptive control technology developed by NASA. Optimal Control Modification is a novel adaptive law that can improve performance and robustness of adaptive control systems. A new technique has been developed to provide an analytical method for computing time delay stability margin for adaptive control systems.

  12. Automated RNA Sample Quality Control

    OpenAIRE

    Borg, Solange; Salowsky, Ruediger; Inche, Adam; Connelly, Matthew; Boland, Dierdre; Padmanabanv, Arunkumar; Graf, Eva; Liu, Melissa Huang

    2014-01-01

    The Agilent 2200 TapeStation system provides a flexible solution for automated analysis of up to 96 samples using pre-packaged reagents and minimal manual handling. Here we present a new assay – the RNA ScreenTape assay – to enable robust quantification and quality analysis of Total RNA samples from both eukaryotic and prokaryotic sources from 100 pg/μl to 500 ng/μl. The new assay additionally benefits from the ability to provide separation of contaminant genomic DNA allowing more accurate pu...

  13. Quality Changes of Frozen Meat During Storage and Control Measures

    Institute of Scientific and Technical Information of China (English)

    DU Jiangping

    2010-01-01

    The frozen is a common method of meat storage, generally applications in meat industrial. However, the quality of meat still have taken place changes even in the low temperature, This article discussion on the changes of frozen meat quality during freezing storage, and give the corresponding control measures.

  14. Discussion of Quality Control Methods of Adverse Drug Reaction Reports%药品不良反应病例报告质量控制的方法探讨

    Institute of Scientific and Technical Information of China (English)

    李泮海; 冯巧巧

    2011-01-01

    结合山东省药品不良反应病例报告质量控制的理论思考和实践探讨,分析并提出控制药品不良反应病例报告质量的微观与宏观控制方法,以期为我国药品不良反应病例报告质量的控制与提高提供参考.%Based on the thought and practice of quality control of adverse drug reaction reports in Shandong Province, the methods of micro-control and macro-control for the adverse drug reaction reports were proposed and analyzed in this paper, to provide valuable reference on the quality control of adverse drug reaction reports.

  15. VPLS Based Quality and Cost Control for Tennessee Eastman Process

    Institute of Scientific and Technical Information of China (English)

    宋凯; 王海清; 李平

    2005-01-01

    Product quality and operation cost control obtain increasing emphases in modern chemical system engineering. To improve the fault detection power of the partial least square (PLS) method for quality control, a new QRPV statistic is proposed in terms of the VP (variable importance in projection) indices of monitored process variables, which is significantly advanced over and different from the conventional Q statistic. QRPV is calculated only by the residuals of the remarkable process variables (RPVs). Therefore, it is the dominant relation between quality and RPV not all process variables (as in the case of the conventional PLS) that is monitored by this new VP-PLS (VPLS) method. The combination of QRPV and T2 statistics is applied to the quality and cost control of the Tennessee Eastman (TE) process, and weak faults can be detected as quickly as possible. Consequently, the product quality of TE process is guaranteed and operation costs are reduced.

  16. Net analyte signal based statistical quality control

    NARCIS (Netherlands)

    Skibsted, E.T.S.; Boelens, H.F.M.; Westerhuis, J.A.; Smilde, A.K.; Broad, N.W.; Rees, D.R.; Witte, D.T.

    2005-01-01

    Net analyte signal statistical quality control (NAS-SQC) is a new methodology to perform multivariate product quality monitoring based on the net analyte signal approach. The main advantage of NAS-SQC is that the systematic variation in the product due to the analyte (or property) of interest is sep

  17. Quality or Control? Management in Higher Education

    Science.gov (United States)

    Milliken, John; Colohan, Gerry

    2004-01-01

    Over the past fifteen years the rationale, organisational infrastructure and delivery of social policy in Britain have undergone radical transformation. Whereas efficiency was the key word of the 1980s, quality was the touchstone of the 1990s and quality control with accountability has become the management philosophy of the new millennium.…

  18. “纵横质控法”在社区高血压管理中的应用体会%Application experience of "vertical and horizontal quality control method" in the community hypertension management

    Institute of Scientific and Technical Information of China (English)

    刘峥; 袁敏青; 杨郗

    2015-01-01

    社区高血压管理是社区公共卫生服务的重要任务,通过运用“纵横质控法”对社区高血压患者进行日常质量控制,随访准确率从53.3%上升至89.6%,社区高血压管理的随访质量得到了有效提高。%Community hypertension management is an important task of the community public health service,through the use of"vertical and horizontal quality control method" for the daily quality control in the community hypertension management,the follow-up accuracy rate increased from 53.3% to 89.6%.The follow-up quality of community hypertension management has been effectively improved.

  19. Quality Control Approaches for Chinese Herbal Medicines

    Institute of Scientific and Technical Information of China (English)

    YUAN Hai-long; ZHANG Tian-tian; XIAO Xiao-he

    2011-01-01

    The current official quality control approaches meet the challenges from the complexity of herbal medicines.In fact,any herbal medicines containing numerous unknown components,its curative effect usually depends on the whole of herbal medicines,so it is impossible and unnecessary to qualitatively and quantitatively study every component.By investigating the limitations of current quality control approaches for herbal medicines and the difference and similarity in the chemical substantial style as well as quality control pattern of herbal medicines,a new quality control approach for Chinese herbal medicines should be explored and designed.The combination approach of chemical analysis with bioassay is promising to be developed and employed in order to ensure the safety and efficacy of Chinese herbal medicines.

  20. Quality Controlled Local Climatological Data (QCLCD) Publication

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Quality Controlled Local Climatological Data (QCLCD) contains summaries from major airport weather stations that include a daily account of temperature extremes,...

  1. Exploration on artificial bored pile construction quality control methods%人工挖孔桩施工质量控制方法探讨

    Institute of Scientific and Technical Information of China (English)

    何文斌

    2015-01-01

    The thesis describes merits and defects of artificial bored pile,and illustrates artificial bored pile construction technology procedures. Starting from three aspects of construction organization design compilation,construction scheme technology discloser and construction examination system compilation,it introduces artificial bored pile construction quality control measures,and puts forward corresponding processing counter-measures to existing construction problems,so as to guarantee artificial bored pile construction quality.%简述了人工挖孔灌注桩的优缺点,概括了人工挖孔桩施工的工艺流程,从施工组织设计的编制、施工方案的技术交底、施工检查制度的制定三方面,介绍了人工挖孔桩施工的质量控制措施,并针对施工中存在的问题,提出了相应的处理对策,确保了人工挖孔桩的施工质量。

  2. The statistical process control methods - SPC

    Directory of Open Access Journals (Sweden)

    Floreková Ľubica

    1998-03-01

    Full Text Available Methods of statistical evaluation of quality – SPC (item 20 of the documentation system of quality control of ISO norm, series 900 of various processes, products and services belong amongst basic qualitative methods that enable us to analyse and compare data pertaining to various quantitative parameters. Also they enable, based on the latter, to propose suitable interventions with the aim of improving these processes, products and services. Theoretical basis and applicatibily of the principles of the: - diagnostics of a cause and effects, - Paret analysis and Lorentz curve, - number distribution and frequency curves of random variable distribution, - Shewhart regulation charts, are presented in the contribution.

  3. Quality assurance and quality control in clinical cytogenetics.

    Science.gov (United States)

    Mikhail, Fady M; Watson, Michael S

    2014-07-14

    The goal of any clinical laboratory should be to provide patients with the most accurate test results possible. This is accomplished through various overlapping programs that continuously monitor and optimize all aspects of a test, including decisions by the laboratory to offer a test, the decision of providers to request the test, the testing itself, and the reporting of results to the referral source and patient. The levels at which test performance and accuracy can be optimized are encompassed under quality control (QC) and quality assurance (QA). The monitoring of QC and QA problems allows for the integration of these parameters into a total quality management program. This unit reviews QC and QA guidelines, in addition to discussing how to establish a quality assurance program.

  4. Quality control of injection moulded micro mechanical parts

    DEFF Research Database (Denmark)

    Gasparin, Stefania; Tosello, Guido; Hansen, Hans Nørgaard

    2009-01-01

    Quality control of micro components is an increasing challenge. Smaller mechanical parts are characterized by smaller tolerance to be verified. This paper focuses on the dimensional verification of micro injection moulded components selected from an industrial application. These parts are measured...... using an Optical Coordinate Measuring Machine (OCMM), which guarantees fast surface scans suitable for in line quality control. The uncertainty assessment of the measurements is calculated following the substitution method. To investigate the influence parameters in optical coordinate metrology two...

  5. Regulation and control method of water quality in waste heat boiler%废热锅炉水质调节的问题及控制方法

    Institute of Scientific and Technical Information of China (English)

    陈世通; 苏庆贺; 林广顺; 孙善楠

    2013-01-01

    According to the waste heat boiler water pH reduction problem in operation, we analyze reasons of boiler water pH reduction is boiler feed water quality does not conform to specified requirements. Taking appropriate method to ensure safe operation of boiler equipment, and put forward the feasible improvements.%根据废热锅炉炉水在运行中出现pH值降低的问题进行分析,找出炉水pH值过低的原因是锅炉给水水质不符合规定要求所致。采取了相应方法保证锅炉设备安全运行,并提出了可行的改进措施。

  6. Iodine absorption cells quality evaluation methods

    Science.gov (United States)

    Hrabina, Jan; Zucco, Massimo; Holá, Miroslava; Šarbort, Martin; Acef, Ouali; Du-Burck, Frédéric; Lazar, Josef; Číp, Ondřej

    2016-12-01

    The absorption cells represent an unique tool for the laser frequency stabilization. They serve as irreplaceable optical frequency references in realization of high-stable laser standards and laser sources for different brands of optical measurements, including the most precise frequency and dimensional measurement systems. One of the most often used absorption media covering visible and near IR spectral range is molecular iodine. It offers rich atlas of very strong and narrow spectral transitions which allow realization of laser systems with ultimate frequency stabilities in or below 10-14 order level. One of the most often disccussed disadvantage of the iodine cells is iodine's corrosivity and sensitivity to presence of foreign substances. The impurities react with absorption media and cause spectral shifts of absorption spectra, spectral broadening of the transitions and decrease achievable signal-to-noise ratio of the detected spectra. All of these unwanted effects directly influence frequency stability of the realized laser standard and due to this fact, the quality of iodine cells must be precisely controlled. We present a comparison of traditionally used method of laser induced fluorescence (LIF) with novel technique based on hyperfine transitions linewidths measurement. The results summarize advantages and drawbacks of these techniques and give a recommendation for their practical usage.

  7. Analytical techniques and quality control in biomedical trace element research

    DEFF Research Database (Denmark)

    Heydorn, K.

    1994-01-01

    The small number of analytical results in trace element research calls for special methods of quality control. It is shown that when the analytical methods are in statistical control, only small numbers of duplicate or replicate results are needed to ascertain the absence of systematic errors cau....../kg. Measurement compatibility is obtained by control of traceability to certified reference materials, (C) 1994 Wiley-Liss, Inc....

  8. Network-based production quality control

    Science.gov (United States)

    Kwon, Yongjin; Tseng, Bill; Chiou, Richard

    2007-09-01

    This study investigates the feasibility of remote quality control using a host of advanced automation equipment with Internet accessibility. Recent emphasis on product quality and reduction of waste stems from the dynamic, globalized and customer-driven market, which brings opportunities and threats to companies, depending on the response speed and production strategies. The current trends in industry also include a wide spread of distributed manufacturing systems, where design, production, and management facilities are geographically dispersed. This situation mandates not only the accessibility to remotely located production equipment for monitoring and control, but efficient means of responding to changing environment to counter process variations and diverse customer demands. To compete under such an environment, companies are striving to achieve 100%, sensor-based, automated inspection for zero-defect manufacturing. In this study, the Internet-based quality control scheme is referred to as "E-Quality for Manufacturing" or "EQM" for short. By its definition, EQM refers to a holistic approach to design and to embed efficient quality control functions in the context of network integrated manufacturing systems. Such system let designers located far away from the production facility to monitor, control and adjust the quality inspection processes as production design evolves.

  9. TECHNIQUES ABOUT DIRECT OPTIMIZING CONTROL OF GREEN SAND QUALITY*

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Green sand casting is still a main method in the world at present and it is very significant to develop the technology of controlling green sand quality. A new concept, from contents test to contents control, is advanced. In order to realize the new idea, a new method to on-line test active clay and moisture of green sand - double powers energizing alternately (DPEA) method is put forwards. The principle of the new method is to energize standard sand sample with AC and DC powers and to test the electric parameters, and then, to calculate active clay and moisture of green sand by using artificial neural network (ANN). Based on this new method, a direct optimizing system for controlling green sand quality is developed. Techniques about testing and controlling methods, hardware and software are discussed.

  10. Quality and methods of developing practice guidelines

    Directory of Open Access Journals (Sweden)

    Clark Otavio

    2002-01-01

    Full Text Available Abstract Background It is not known whether there are differences in the quality and recommendations between evidence-based (EB and consensus-based (CB guidelines. We used breast cancer guidelines as a case study to assess for these differences. Methods Five different instruments to evaluate the quality of guidelines were identified by a literature search. We also searched MEDLINE and the Internet to locate 8 breast cancer guidelines. These guidelines were classified in three categories: evidence based, consensus based and consensus based with no explicit consideration of evidence (CB-EB. Each guideline was evaluated by three of the authors using each of the instruments. For each guideline we assessed the agreement among 14 decision points which were selected from the NCCN (National Cancer Comprehensive Network guidelines algorithm. For each decision point we recorded the level of the quality of the information used to support it. A regression analysis was performed to assess if the percentage of high quality evidence used in the guidelines development was related to the overall quality of the guidelines. Results Three guidelines were classified as EB, three as CB-EB and two as CB. The EB guidelines scored better than CB, with the CB-EB scoring in the middle among all instruments for guidelines quality assessment. No major disagreement in recommendations was detected among the guidelines regardless of the method used for development, but the EB guidelines had a better agreement with the benchmark guideline for any decision point. When the source of evidence used to support decision were of high quality, we found a higher level of full agreement among the guidelines' recommendations. Up to 94% of variation in the quality score among guidelines could be explained by the quality of evidence used for guidelines development. Conclusion EB guidelines have a better quality than CB guidelines and CB-EB guidelines. Explicit use of high quality evidence

  11. Advances in quality control for dioxins monitoring and evaluation of measurement uncertainty from quality control data.

    Science.gov (United States)

    Eppe, Gauthier; De Pauw, Edwin

    2009-08-01

    This paper describes an application of multivariate and multilevel quality control charts with the aim of improving the internal quality control (IQC) procedures for the monitoring of dioxins and dioxin-like PCBs analysis in food. Dioxin analysts have to use the toxic equivalent concept (TEQ) to assess the toxicity potential of a mixture of dioxin-like compounds. The TEQ approach requires quantifying individually 29 dioxin-like compounds. Monitoring the congeners separately on univariate QC charts is misleading owing to the increase of false alarm rate. We propose to subdivide the TEQ value into 3 sub-groups and to control simultaneously the 3 variables in a T(2) chart. When a T(2) exceeds the upper control limit, it acts as a warning to trigger additional investigations on individual congeners. We discuss the minimum number of runs required to reliably estimate the QC chart parameters and we suggest using data from multilevel QC charts to properly characterize the standard deviations and the correlation coefficients. Moreover, the univariate QC chart can be sensitised to detect systematic errors by using exponentially weighted moving average (EWMA) technique. The EWMA chart provides an additional guidance on setting appropriate criteria to control the method bias and to support trend analysis. Finally, we present an estimate of measurement uncertainty by computing the accuracy profile in a retrospective way with the QC data generated and we discuss assessment of compliance with regulatory maximum levels.

  12. With 8D method to excellent quality

    Directory of Open Access Journals (Sweden)

    Marjanca Krajnc

    2012-10-01

    Full Text Available RQ: The research aims to establish the suitability of the 8D methodology for complaint settlement, and to identify any resulting improvement in quality.Purpose: Studies that have research the 8D method are scarce in international literature. Consequently, we decided to assess, based on theoretical premises, the suitability of the 8D method used by an organization, and the efficiency of quality performance directly associated with the 8D method. We will establish whether the use ofthe 8D method results in quality improvement.Method: The research will be carried out using qualitative analysis in the form of a case study of the 8D method used in an organization. I will discuss, based on real and relevant data, the approaches implemented by individual 8D method steps, indicating the integrated supplemental tools. In the quantitative part, I will identify the defective product trends (PPM and the trends of costs related to defective products.Results: The 8D method used for complaint settlement contributes to improved quality and company performance.Organization: The results can be used by the management in continuous improvement as additional motivation for more consistent and effective use, and for additional support to problem-solving coordinators and teams.Society: The findings can also be applied by society at large, mostly companies and public services.Originality: Research on this topic or combination has not yet been conductedLimitations: The sample studied is small, limited to one large company. It includes only the data obtained through the use of the 8D method.

  13. Mixture-process variable approach to optimize a microemulsion electrokinetic chromatography method for the quality control of a nutraceutical based on coenzyme Q10.

    Science.gov (United States)

    Piepel, G; Pasquini, B; Cooley, S; Heredia-Langner, A; Orlandini, S; Furlanetto, S

    2012-08-15

    In recent years, multivariate optimization has played an increasing role in analytical method development. ICH guidelines recommend using statistical design of experiments to identify the design space, in which multivariate combinations of composition variables and process variables have been demonstrated to provide quality results. Considering a microemulsion electrokinetic chromatography method (MEEKC), the performance of the electrophoretic run depends on the proportions of mixture components (MCs) of the microemulsion and on the values of process variables (PVs). In the present work, for the first time in the literature, a mixture-process variable (MPV) approach was applied to optimize a MEEKC method for the analysis of coenzyme Q10 (Q10), ascorbic acid (AA), and folic acid (FA) contained in nutraceuticals. The MCs (buffer, surfactant-cosurfactant, oil) and the PVs (voltage, buffer concentration, buffer pH) were simultaneously changed according to a MPV experimental design. A 62-run MPV design was generated using the I-optimality criterion, assuming a 46-term MPV model allowing for special-cubic blending of the MCs, quadratic effects of the PVs, and some MC-PV interactions. The obtained data were used to develop MPV models that express the performance of an electrophoretic run (measured as peak efficiencies of Q10, AA, and FA) in terms of the MCs and PVs. Contour and perturbation plots were drawn for each of the responses. Finally, the MPV models and criteria for the peak efficiencies were used to develop the design space and an optimal subregion (i.e., the settings of the mixture MCs and PVs that satisfy the respective criteria), as well as a unique optimal combination of MCs and PVs.

  14. Mixture-process variable approach to optimize a microemulsion electrokinetic chromatography method for the quality control of a nutraceutical based on coenzyme Q10

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, Gregory F.; Pasquini, Benedetta; Cooley, Scott K.; Heredia-Langner, Alejandro; Orlandini, Serena; Furlanetto, Sandra

    2012-08-15

    In recent years, multivariate optimization has played an increasing role in analytical method development. ICH guidelines recommend using statistical design of experiments to identify the design space, in which multivariate combinations of composition variables and process variables have been demonstrated to provide quality results. Considering a microemulsion electrokinetic chromatography method (MEEKC), the performance of the electrophoretic run depends on the proportions of mixture components (MCs) of the microemulsion and on the values of process variables (PVs). In the present work, for the first time in the literature, a mixture-process variable (MPV) approach was applied to optimize a MEEKC method for the analysis of coenzyme Q10 (Q10), ascorbic acid (AA), and folic acid (FA) contained in nutraceuticals. The MCs (buffer, surfactant-cosurfactant, oil) and the PVs (voltage, buffer concentration, buffer pH) were simultaneously changed according to a MPV experimental design. A 62-run MPV design was generated using the I-optimality criterion, assuming a 46-term MPV model allowing for special-cubic blending of the MCs, quadratic effects of the PVs, and some MC-PV interactions. The obtained data were used to develop MPV models that express the performance of an electrophoretic run (measured as peak efficiencies of Q10, AA, and FA) in terms of the MCs and PVs. Contour and perturbation plots were drawn for each of the responses. Finally, the MPV models and criteria for the peak efficiencies were used to develop the design space and an optimal subregion (i.e., the settings of the mixture MCs and PVs that satisfy the respective criteria), as well as a unique optimal combination of MCs and PVs.

  15. 食品、药品微生物检测实验室质量控制方法分析%Analysis of laboratory quality control methods for microbiological testing of food and medicine

    Institute of Scientific and Technical Information of China (English)

    刘锐萍; 王峰; 刘珊珊; 杜伟; 赵广西

    2013-01-01

    Systematic analysis of the laboratory quality control methods for microbiological testing of food and medicine was performed,including analysis on the overall control of environment condition,the management of sterile room,sample management,equipment management,personnel management,medium quality control,standard bacterial (toxic) strain management,process control,and record maintein,aiming at providing systematic guidance for the quality control of microbiological laboratory work,and improving the accuracy of the microbial tests.%系统分析食品、药品微生物检测实验室的质量控制方法,从总体环境条件控制、微生物室管理、样品管理、仪器设备管理、人员管理、培养基质量控制、标准菌(毒)种管理、操作过程控制、记录管理等9个方面进行系统分析,对微生物实验室的质量控制工作提供系统指导,提高微生物检测结果的准确性.

  16. New approach to equipment quality evaluation method with distinct functions

    Directory of Open Access Journals (Sweden)

    Milisavljević Vladimir M.

    2016-01-01

    Full Text Available The paper presents new approach for improving method for quality evaluation and selection of equipment (devices and machinery by applying distinct functions. Quality evaluation and selection of devices and machinery is a multi-criteria problem which involves the consideration of numerous parameters of various origins. Original selection method with distinct functions is based on technical parameters with arbitrary evaluation of each parameter importance (weighting. Improvement of this method, presented in this paper, addresses the issue of weighting of parameters by using Delphi Method. Finally, two case studies are provided, which included quality evaluation of standard boilers for heating and evaluation of load-haul-dump (LHD machines, to demonstrate applicability of this approach. Analytical Hierarchical Process (AHP is used as a control method.

  17. 计算机辅助工业设计中NURBS曲线质量控制方法研究%Research on control method of NURBS curve quality in CAID

    Institute of Scientific and Technical Information of China (English)

    艾萍

    2013-01-01

    Iu CAID software based on NURBS technology,the quality of curve directly affecrs the quality of surface and the degree of difficulty for post-editing and modification of the surface,so high quality curwe is the key to build high-quality surface.Combining the basic theory of NURBS curve with practical experience,the study on the method of controlling the quality of the NURBS curves is conducted,and the implementation scheme is proposed to improve the quality of the NURBS cmrve.%在基于NURBS技术的计算机辅助工业设计(CAID)软件中,曲线的质量直接影响到曲面的质量以及后期曲面编辑与修改的难易程度,因此,好的曲线是构建优质曲面的核心与关键;从NURBS曲线的基本理论出发,基于CAID软件平台,结合实际经验,对NURBS曲线质量控制方法进行了研究,提出了提高NURBS曲线质量的实现方案.

  18. Harmonisation Initiatives of Copernicus Data Quality Control

    Science.gov (United States)

    Vescovi, F. D.; Lankester, T.; Coleman, E.; Ottavianelli, G.

    2015-04-01

    The Copernicus Space Component Data Access system (CSCDA) incorporates data contributions from a wide range of satellite missions. Through EO data handling and distribution, CSCDA serves a set of Copernicus Services related to Land, Marine and Atmosphere Monitoring, Emergency Management and Security and Climate Change. The quality of the delivered EO products is the responsibility of each contributing mission, and the Copernicus data Quality Control (CQC) service supports and complements such data quality control activities. The mission of the CQC is to provide a service of quality assessment on the provided imagery, to support the investigation related to product quality anomalies, and to guarantee harmonisation and traceability of the quality information. In terms of product quality control, the CQC carries out analysis of representative sample products for each contributing mission as well as coordinating data quality investigation related to issues found or raised by Copernicus users. Results from the product analysis are systematically collected and the derived quality reports stored in a searchable database. The CQC service can be seen as a privileged focal point with unique comparison capacities over the data providers. The comparison among products from different missions suggests the need for a strong, common effort of harmonisation. Technical terms, definitions, metadata, file formats, processing levels, algorithms, cal/val procedures etc. are far from being homogeneous, and this may generate inconsistencies and confusion among users of EO data. The CSCDA CQC team plays a significant role in promoting harmonisation initiatives across the numerous contributing missions, so that a common effort can achieve optimal complementarity and compatibility among the EO data from multiple data providers. This effort is done in coordination with important initiatives already working towards these goals (e.g. INSPIRE directive, CEOS initiatives, OGC standards, QA4EO

  19. Quality Control of Trichinella Testing at the Slaughterhouse Laboratory: Evaluation of the Use of a 400-Micrometer-Mesh-Size Sieve in the Magnetic Stirrer Method.

    Science.gov (United States)

    Franssen, Frits; van Andel, Esther; Swart, Arno; van der Giessen, Joke

    2016-02-01

    The performance of a 400-μm-mesh-size sieve (sieve400) has not previously been compared with that of a 180-μm-mesh-size sieve (sieve180). Using pork samples spiked with 0 to 10 Trichinella muscle larvae and an artificial digestion method, sieve performance was evaluated for control of Trichinella in meat-producing animals. The use of a sieve400 resulted in 12% lower larval counts, 147% more debris, and 28% longer counting times compared with the use of a sieve180. Although no false-negative results were obtained, prolonged counting times with the sieve400 may have an impact on performance in a high-throughput environment such as a slaughterhouse laboratory. Based on our results, the sieve180 remains the sieve of choice for Trichinella control in meat in slaughterhouse laboratories, according to the European Union reference method (European Commission regulation 2075/2005). Furthermore, the results of the present study contribute to the discussion of harmonization of meat inspection requirements among countries.

  20. Infrared and Raman spectroscopic methods for characterization of Taxus baccata L.--Improved taxane isolation by accelerated quality control and process surveillance.

    Science.gov (United States)

    Gudi, Gennadi; Krähmer, Andrea; Koudous, Iraj; Strube, Jochen; Schulz, Hartwig

    2015-10-01

    Different yew species contain poisonous taxane alkaloids which serve as resources for semi-synthesis of anticancer drugs. The highly variable amounts of taxanes demand new methods for fast characterization of the raw plant material and the isolation of the target structures during phyto extraction. For that purpose, applicability of different vibrational spectroscopy methods in goods receipt of raw plant material and in process control was investigated and demonstrated in online tracking isolation and purification of the target taxane 10-deacetylbaccatin III (10-DAB) during solvent extraction. Applying near (NIRS) and mid infrared spectroscopy (IRS) the amount of botanical impurities in mixed samples of two different yew species (R(2)=0.993), the leave-to-wood ratio for Taxus baccata material (R(2)=0.94) and moisture in dried yew needles (R(2)=0.997) can be quantified. By partial least square analysis (PCA) needles of different Coniferales species were successfully discriminated by Attenuated Total Reflectance-Fourier-Transform Infrared Spectroscopy (ATR-FT-IR). The analytical potential of ATR-FT-IR and Fourier Transform-Raman Spectroscopy (FT-RS) in process control of extraction and purification of taxanes is demonstrated for determination of the water content in methanolic yew extracts (R(2)=0.999) and for quantification of 10-DAB (R(2)=0.98) on a highly sophisticated level. The decrease of 10-DAB in the plant tissue during extraction was successfully visualized by FT-IR imaging of thin cross sections providing new perspectives for process control and design. Copyright © 2015 Elsevier B.V. All rights reserved.

  1. Protein quality control in the nucleus

    DEFF Research Database (Denmark)

    Nielsen, Sofie V.; Poulsen, Esben Guldahl; Rebula, Caio A.

    2014-01-01

    to aggregate, cells have evolved several elaborate quality control systems to deal with these potentially toxic proteins. First, various molecular chaperones will seize the misfolded protein and either attempt to refold the protein or target it for degradation via the ubiquitin-proteasome system...... to be particularly active in protein quality control. Thus, specific ubiquitin-protein ligases located in the nucleus, target not only misfolded nuclear proteins, but also various misfolded cytosolic proteins which are transported to the nucleus prior to their degradation. In comparison, much less is known about...... these mechanisms in mammalian cells. Here we highlight recent advances in our understanding of nuclear protein quality control, in particular regarding substrate recognition and proteasomal degradation....

  2. 30 CFR 28.31 - Quality control plans; contents.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality control plans; contents. 28.31 Section... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.31 Quality control plans; contents. (a) Each quality control plan shall contain provisions for the management of quality, including:...

  3. Frontiers in statistical quality control 11

    CERN Document Server

    Schmid, Wolfgang

    2015-01-01

    The main focus of this edited volume is on three major areas of statistical quality control: statistical process control (SPC), acceptance sampling and design of experiments. The majority of the papers deal with statistical process control, while acceptance sampling and design of experiments are also treated to a lesser extent. The book is organized into four thematic parts, with Part I addressing statistical process control. Part II is devoted to acceptance sampling. Part III covers the design of experiments, while Part IV discusses related fields. The twenty-three papers in this volume stem from The 11th International Workshop on Intelligent Statistical Quality Control, which was held in Sydney, Australia from August 20 to August 23, 2013. The event was hosted by Professor Ross Sparks, CSIRO Mathematics, Informatics and Statistics, North Ryde, Australia and was jointly organized by Professors S. Knoth, W. Schmid and Ross Sparks. The papers presented here were carefully selected and reviewed by the scientifi...

  4. On quality control of single-floor SBS roof waterproof craft with heat fusion method%热熔法单层 SBS 屋面防水工艺工程质量控制

    Institute of Scientific and Technical Information of China (English)

    赵基平

    2015-01-01

    结合工作经验,介绍了热熔法单层SBS屋面防水工艺原材料的控制要点,主要阐述了单层SBS屋面防水施工的质量控制措施,并对施工时适宜的气候条件进行了研究,以避免屋面防水质量问题的发生。%Combining with the work experience,the paper introduces the controlling measures for the single-floor SBS roof waterproof craft with heat fusion method,mainly illustrates the quality control measures for the construction,and researches the suitable climate conditions of the con-struction,so as to avoid the defects in the roof waterproof quality.

  5. Application of PDCA circulation method in quality control at health examination centre%PDCA循环法在体检中心质量控制中的应用

    Institute of Scientific and Technical Information of China (English)

    陈庆瑜; 陈锦武; 甘小玲; 廖蓓

    2014-01-01

    目的 探讨如何做好体检中心质量控制工作,促进健康体检规范化建设和学科管理水平的全面提升.方法 将PDCA循环法运用于健康体检的各个环节,在组织计划、执行实施、检查监控和信息反馈处理的全过程进行体检质量的全面控制管理.结果 客户满意度呈现上升趋势,学科管理水平和综合效益进一步提升.结论 PDCA循环法对体检质量的持续改进和学科管理水平的不断提高具有重要意义.%Objective To investigate how to carry out quality control at health examination centre,in order to promote the standardization of health examination and management level.Method PDCA circulation method was applied in every link of health examination to control the quality with plan,do,check and action.Result Customers' satisfaction degree rose.The management level and comprehensive effectiveness promoted.Conclusion PDCA circulation method is important for continuous improvement of the quality of health examination and the promotion of management level.

  6. HPLC for quality control of polyimides

    Science.gov (United States)

    Young, P. R.; Sykes, G. F.

    1979-01-01

    High Pressure Liquid Chromatography (HPLC) as a quality control tool for polyimide resins and prepregs are presented. A data base to help establish accept/reject criteria for these materials was developed. This work is intended to supplement, not replace, standard quality control tests normally conducted on incoming resins and prepregs. To help achieve these objectives, the HPLC separation of LARC-160 polyimide precursor resin was characterized. Room temperature resin aging effects were studied. Graphite reinforced composites made from fresh and aged resin were fabricated and tested to determine if changes observed by HPLC were significant.

  7. Statistical quality control a loss minimization approach

    CERN Document Server

    Trietsch, Dan

    1999-01-01

    While many books on quality espouse the Taguchi loss function, they do not examine its impact on statistical quality control (SQC). But using the Taguchi loss function sheds new light on questions relating to SQC and calls for some changes. This book covers SQC in a way that conforms with the need to minimize loss. Subjects often not covered elsewhere include: (i) measurements, (ii) determining how many points to sample to obtain reliable control charts (for which purpose a new graphic tool, diffidence charts, is introduced), (iii) the connection between process capability and tolerances, (iv)

  8. HPLC for quality control of polyimides

    Science.gov (United States)

    Young, P. R.; Sykes, G. F.

    1979-01-01

    High Pressure Liquid Chromatography (HPLC) as a quality control tool for polyimide resins and prepregs are presented. A data base to help establish accept/reject criteria for these materials was developed. This work is intended to supplement, not replace, standard quality control tests normally conducted on incoming resins and prepregs. To help achieve these objectives, the HPLC separation of LARC-160 polyimide precursor resin was characterized. Room temperature resin aging effects were studied. Graphite reinforced composites made from fresh and aged resin were fabricated and tested to determine if changes observed by HPLC were significant.

  9. Métodos de controle de plantas daninhas e seus impactos na qualidade microbiana de solo sob cafeeiro Methods of weed control and their impacts on microbial quality of soil under coffee

    Directory of Open Access Journals (Sweden)

    Rogério Melloni

    2013-02-01

    empregado para o controle de plantas daninhas em cafeeiro.Minas Gerais stands out as the largest coffee-producing state of Brazil. This crop is extremely susceptible to weeds, which can be handled by manual, mechanized and/or chemical methods, which strongly affect production costs and soil quality. In this sense, the objective of this study was to evaluate the effect of different weed control methods in and between coffee rows on the soil microbiota and its processes. For this purpose, soil samples were taken in April 2010 from an Oxisol on the experimental farm of the Agricultural Research Company of Minas Gerais (EPAMIG, in São Sebastião do Paraíso, MG, at a depth of 0-10 cm in the middle of the track (interrow of coffee and 20 cm away from the stem of the coffee trees (row, to determine the following properties: total density of bacteria and fungi, phosphate solubilizers, cellulolytic and ammonifying microorganisms, non-symbiotic diazotrophic bacteria, carbon biomass and microbial activity, metabolic quotient (qCO2 and enzymatic activity by the hydrolysis of fluorescein diacetate. The coffee plants were subjected to seven methods of weed control: mowing, coffee tandem disk harrow (grid, rotary tiller, post-emergence herbicide, pre-emergence herbicide, manual weeding, and no weed control. The results showed the complexity of the effects of these different methods on soil and its processes, with lowest impacts of manual weeding and rotary hoe. Mowing, coffee tandem disk harrow, no weed control and pre-emergence herbicide caused intermediate impacts, while the application of post-emergence herbicides in-between coffee rows caused the most negative impacts on the evaluated properties. It is suggested that these impacts must be considered when evaluating and selecting the method for weed control in coffee plants.

  10. Transformation method and wave control

    Science.gov (United States)

    Chang, Zheng; Hu, Jin; Hu, Geng-Kai

    2010-12-01

    Transformation method provides an efficient way to control wave propagation by materials. The transformed relations for field and material during a transformation are essential to fulfill this method. We propose a systematic method to derive the transformed relations for a general physic process, the constraint conditions are obtained by considering geometrical and physical constraint during a mapping. The proposed method is applied to Navier's equation for elastodynamics, Helmholtz's equation for acoustic wave and Maxwell's equation for electromagnetic wave, the corresponding transformed relations are derived, which can be used in the framework of transformation method for wave control. We show that contrary to electromagnetic wave, the transformed relations are not uniquely determined for elastic wave and acoustic wave, so we have a freedom to choose them differently. Using the obtained transformed relations, we also provide some examples for device design, a concentrator for elastic wave, devices for illusion acoustic and illusion optics are conceived and validated by numerical simulations.

  11. Ways to control quality of electric equipment in the coal industry

    Energy Technology Data Exchange (ETDEWEB)

    Shipilov, A.D.; Nabokov, E.P.

    1982-01-01

    A structure is proposed for organization in the coal industry of a permanent service for controlling quality of electrical engineering equipment. A form was developed for introduction of recommendations to improve quality. Methods are suggested for evaluating the quality level as applied to specific tasks of controlling quality of the electrical equipment used in mining.

  12. Extracellular quality control in the epididymis

    Institute of Scientific and Technical Information of China (English)

    Gail A. Cornwall; H. Henning von Horsten; Douglas Swartz; Seethal Johnson; Kim Chau; Sandra Whelly

    2007-01-01

    The epididymal lumen represents a unique extracellular environment because of the active sperm maturation process that takes place within its confines. Although much focus has been placed on the interaction of epididymal secretory proteins with spermatozoa in the lumen, very little is known regarding how the complex epididymal milieu as a whole is maintained, including mechanisms to prevent or control proteins that may not stay in their native folded state following secretion. Because some misfolded proteins can form cytotoxic aggregate structures known as amyloid, it is likely that control/surveillance mechanisms exist within the epididymis to protect against this process and allow sperm maturation to occur. To study protein aggregation and to identify extracellular quality control mechanisms in the epididymis, we used the cystatin family of cysteine protease inhibitors, including cystatin-related epididymal spermatogenic and cystatin C as molecular models because both proteins have inherent properties to aggregate and form amyloid. In this chapter, we present a brief summary of protein aggregation by the amyloid pathway based on what is known from other organ systems and describe quality control mechanisms that exist intracellularly to control protein misfolding and aggregation. We then present a summary of our studies of cystatinrelated epididymal spermatogenic (CRES) oligomerization within the epididymal lumen, including studies suggesting that transglutaminase cross-linking may be one mechanism of extracellular quality control within the epididymis.

  13. Outsourcing University Degrees: Implications for Quality Control

    Science.gov (United States)

    Edwards, Julie; Crosling, Glenda; Edwards, Ron

    2010-01-01

    Education institutions worldwide have and continue to seek opportunities to spread their offerings abroad. While the provision of courses to students located overseas through partner institutions has many advantages, it raises questions about quality control that are not as applicable to other forms of international education. This paper uses a…

  14. Outsourcing University Degrees: Implications for Quality Control

    Science.gov (United States)

    Edwards, Julie; Crosling, Glenda; Edwards, Ron

    2010-01-01

    Education institutions worldwide have and continue to seek opportunities to spread their offerings abroad. While the provision of courses to students located overseas through partner institutions has many advantages, it raises questions about quality control that are not as applicable to other forms of international education. This paper uses a…

  15. Qualitative and quantitative analysis of multiple components for quality control of Deng-Zhan-Sheng-Mai capsules by ultra high performance liquid chromatography tandem mass spectrometry method coupled with chemometrics.

    Science.gov (United States)

    Jiang, Pin; Lu, Yan; Chen, Daofeng

    2017-02-01

    Deng-Zhan-Sheng-Mai capsules are a well-known traditional Chinese patent medicine that was developed in China for the treatment of ischemic stroke. Its quality control focuses on Erigerontis Herba but ignores the contributions of Ginseng Radix et Rhizoma, Schisandrae Chinensis Fructus, and Ophiopogonis Radix. To improve the quality standards for this medicine, this work reports the application of a systematic ultra high performance liquid chromatography tandem mass spectrometric method coupled with chemometrics. Three qualitative and quantitative parameters are established for the evaluation of quality: chemical profiling, the relationship between the contents of 18 compounds and the antioxidant activity, and chemometric analysis. A total of 55 compounds, including 20 phenolic acids, 10 flavonoids, 15 saponins, and 10 lignans, were identified. The method for the quantitative determination of the aforementioned 18 compounds was validated. The limit of quantification ranged from 0.13 to 9.60 ng/mL. The overall recoveries ranged from 95.31 to 103.54%. Hierarchical cluster analysis and principal component analysis were applied to the data of 18 components in ten batches of samples. Nine compounds, including scutellarin, 3,5-O-dicaffeoylquinic acid, 4,5-O-dicaffeoylquinic acid, ginsenoside Rb1, ginsenoside Re, ginsenoside Rg1, ophiopogonin D, schisandrin, and schisandrol B, are suggested as chemical markers for evaluating the quality. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Steel mill products analysis using qualities methods

    Directory of Open Access Journals (Sweden)

    B. Gajdzik

    2016-10-01

    Full Text Available The article presents the subject matter of steel mill product analysis using quality tools. The subject of quality control were bolts and a ball bushing. The Pareto chart and fault mode and effect analysis (FMEA were used to assess faultiness of the products. The faultiness analysis in case of the bolt enabled us to detect the following defects: failure to keep the dimensional tolerance, dents and imprints, improper roughness, lack of pre-machining, non-compatibility of the electroplating and faults on the surface. Analysis of the ball bushing has also revealed defects such as: failure to keep the dimensional tolerance, dents and imprints, improper surface roughness, lack of surface premachining as well as sharp edges and splitting of the material.

  17. Application of Cone Beam Computed Tomography and Its Quality Control Method%锥形束X射线CT的应用现状及其质量控制检测方法

    Institute of Scientific and Technical Information of China (English)

    肖虹; 高林峰; 姚杰; 季贵毅

    2014-01-01

    作为一种新兴医学影像技术,锥束CT已应用于多种医疗实践。然而,对于各种型号锥束CT设备的质量控制尚缺乏一种较为合适的工具来对其图像质量进行评估。本文结合实际工作经验,分析了锥束CT不同于其他医用X射线诊断设备的特点,介绍了锥束CT的应用现状,并结合国内外现有的文献资料,对其质量控制检测的参数及方法进行了阐述。%Cone-beam CT has been used in many medical practices as a kind of emerging medical imaging technology. However, optimization and quality control of CBCT devices is hampered due to the lack of appropriate tools and methods for image quality assessment. This paper analyzes the different characteristics of cone-beam CT and other kinds of X-ray diagnostic devices, also introduces the application and quality control methods of cone-beam CT.

  18. Laboratory diagnostic methods, system of quality and validation

    Directory of Open Access Journals (Sweden)

    Ašanin Ružica

    2005-01-01

    Full Text Available It is known that laboratory investigations secure safe and reliable results that provide a final confirmation of the quality of work. Ideas, planning, knowledge, skills, experience, and environment, along with good laboratory practice, quality control and reliability of quality, make the area of biological investigations very complex. In recent years, quality control, including the control of work in the laboratory, is based on international standards and is used at that level. The implementation of widely recognized international standards, such as the International Standard ISO/IEC 17025 (1 and the implementing of the quality system series ISO/IEC 9000 (2 have become the imperative on the grounds of which laboratories have a formal, visible and corresponding system of quality. The diagnostic methods that are used must constantly yield results which identify the animal as positive or negative, and the precise status of the animal is determined with a predefined degree of statistical significance. Methods applied on a selected population reduce the risk of obtaining falsely positive or falsely negative results. A condition for this are well conceived and documented methods, with the application of the corresponding reagents, and work with professional and skilled staff. This process requires also a consistent implementation of the most rigorous experimental plans, epidemiological and statistical data and estimations, with constant monitoring of the validity of the applied methods. Such an approach is necessary in order to cut down the number of misconceptions and accidental mistakes, for a referent population of animals on which the validity of a method is tested. Once a valid method is included in daily routine investigations, it is necessary to apply constant monitoring for the purpose of internal quality control, in order adequately to evaluate its reproducibility and reliability. Consequently, it is necessary at least twice yearly to conduct

  19. Statistical quality control through overall vibration analysis

    Science.gov (United States)

    Carnero, M. a. Carmen; González-Palma, Rafael; Almorza, David; Mayorga, Pedro; López-Escobar, Carlos

    2010-05-01

    The present study introduces the concept of statistical quality control in automotive wheel bearings manufacturing processes. Defects on products under analysis can have a direct influence on passengers' safety and comfort. At present, the use of vibration analysis on machine tools for quality control purposes is not very extensive in manufacturing facilities. Noise and vibration are common quality problems in bearings. These failure modes likely occur under certain operating conditions and do not require high vibration amplitudes but relate to certain vibration frequencies. The vibration frequencies are affected by the type of surface problems (chattering) of ball races that are generated through grinding processes. The purpose of this paper is to identify grinding process variables that affect the quality of bearings by using statistical principles in the field of machine tools. In addition, an evaluation of the quality results of the finished parts under different combinations of process variables is assessed. This paper intends to establish the foundations to predict the quality of the products through the analysis of self-induced vibrations during the contact between the grinding wheel and the parts. To achieve this goal, the overall self-induced vibration readings under different combinations of process variables are analysed using statistical tools. The analysis of data and design of experiments follows a classical approach, considering all potential interactions between variables. The analysis of data is conducted through analysis of variance (ANOVA) for data sets that meet normality and homoscedasticity criteria. This paper utilizes different statistical tools to support the conclusions such as chi squared, Shapiro-Wilks, symmetry, Kurtosis, Cochran, Hartlett, and Hartley and Krushal-Wallis. The analysis presented is the starting point to extend the use of predictive techniques (vibration analysis) for quality control. This paper demonstrates the existence

  20. 隔离器饲育SPF鸡微生物质量控制方法的建立%Establishment of microbiological quality control methods on breeding SPF chickens raised in the isolators

    Institute of Scientific and Technical Information of China (English)

    吴韬奋; 张瑞忠; 孙凤萍; 王佳乐

    2013-01-01

    Objective To establish production management and the methods of microbiological quality control on breeding SPF chickens raised in the isolator. Methods The chickens were bred in the isolator after the eggs from introduced SPF chickens were hatched out. The sera obtained from 10 ,20,40-week-old SPF chickens were used to monitor microbiological quality in order to detect the effectiveness of the current production management and the methods of microbiological quality control on SPF chickens. Results Because the hatching process was not strickly controlled during the early stage of breeding SPF chickens in the isolator,there were the emergence of microbiological contamination. Microbiological condition of the isolator breeding SPF chickens was effectively controlled after improving the operation management during the hatching process. Conclusion If the disinfection during all breeding stages is strengthened ,the microbiological quality of SPF chickens in the isolator could be ensured. The appropriate control on the density of SPF chickens in the isolator is not only beneficial to the breeding of SPF chickens and the recycling of hatching eggs ,but also helpful to the control of environmental microbiology.%目的 建立隔离器饲育SPF鸡生产管理方式,探讨并建立其微生物质量控制方法.方法 对引进的SPF鸡种蛋进行孵化后,将种鸡置于隔离器中进行饲养,在种鸡10、20、40周龄时采取鸡血清进行微生物质量监测,检验当前SPF鸡生产管理和微生物质量控制方法的有效性.结果 隔离器饲育SPF鸡初期由于对孵化环节控制不严出现了微生物污染现象.在对孵化环节操作管理改进后,隔离器饲育SPF鸡的微生物状况得到控制.结论通过加强各个环节消毒,隔离器饲育环境能够保证SPF鸡的微生物质量.适当控制隔离器内SPF鸡的密度不仅有利于SPF鸡的繁育和种蛋回收,而且有利于环境微生物的控制.

  1. Quality control of parasitology stool examination in Tabriz clinical laboratories

    Directory of Open Access Journals (Sweden)

    shahram Khademvatan

    2011-06-01

    Full Text Available The purpose of quality control program was to make doctors and laboratory personnel trust in laboratory results and consequently increasing confidence in laboratory achievements. The quality assurance means raising the level of quality in all tests that lead to raising the level of work efficiency and laboratories including minimum expense for society and minimum time for lab personnel. This study aimed to assess and determine the accuracy and precision of results in Tabriz medical diagnostic laboratories. Materials and Methods: In this retrospective study, 790 stool samples were selected randomly and tested by standard methods.Student t- test, SPSS software and sensitivity and accuracy formulas were used for data analysis. Results: The sensitivity was 62%, 22% and 8% with 95% confidence intervals for worm's eggs, protozoan cysts and trophozoite detection respectively. Conclusion: To elevate quality assurance in clinical diagnostic laboratory, monitoring and check of the laboratories by standard methods continually should be done.

  2. Using statistical methods of quality management in logistics processes

    Directory of Open Access Journals (Sweden)

    Tkachenko Alla

    2016-04-01

    Full Text Available The purpose of the paper is to study the application of statistical methods of logistics process quality management at a large industrial enterprise and testing the theoretical studies. The analysis of the publications shows that a significant number of works by both Ukrainian and foreign authors has been dedicated to the research of quality management, while statistical methods of quality management have only been thoroughly analyzed by a small number of researchers, since these methods are referred to as classical, that is, those that are considered well-known and do not require special attention of modern scholars. In the authors’ opinion, the logistics process is a process of transformation and movement of material and accompanying flows by ensuring management freedom under the conditions of sequential interdependencies; standardization; synchronization; sharing information, and consistency of incentives, using innovative methods and models. In our study, we have shown that the management of logistics processes should use such statistical methods of quality management as descriptive statistics, experiment planning, hypotheses testing, measurement analysis, process opportunities analysis, regression analysis, reliability analysis, sampling, modeling, maps of statistical process control, specification of statistical tolerance, time series analysis. The proposed statistical methods of logistics processes quality management have been tested at the large industrial enterprise JSC "Dniepropetrovsk Aggregate Plant" that specializes in manufacturing hydraulic control valves. The findings suggest that the main purpose in the sphere of logistics processes quality is the continuous improvement of the mining equipment production quality through the use of innovative processes, advanced management systems and information technology. This will enable the enterprise to meet the requirements and expectations of their customers. It has been proved that the

  3. Discuss on Construction Quality Control Method of Building Mechanical and Electrical Installation%浅谈建筑机电安装的施工质量控制

    Institute of Scientific and Technical Information of China (English)

    金建雷

    2014-01-01

    Mechanical and electrical instal ation has a strong technicality and comprehensive, which needs managers give ful play to the coordination and management ability. The construction quality of mechanical and electrical instal ation project has important influence to the whole construction quality, so we should pay more at ention to the construction quality of mechanical and electrical instal ation project.%机电安装有着很强的技术性和综合性,需要管理者充分发挥协调、组织和管理能力。机电安装工程施工质量的好坏直接关系到整个建筑工程质量的好坏,所以我们要更加注重机电安装工程的施工质量。

  4. Quality control of the documentation process in electronic economic activities

    Directory of Open Access Journals (Sweden)

    Krutova A.S.

    2017-06-01

    Full Text Available It is proved that the main tool that will provide adequate information resources e economic activities of social and economic relations are documenting quality control processes as the basis of global information space. Directions problems as formation evaluation information resources in the process of documentation, namely development tools assess the efficiency of the system components – qualitative assessment; development of mathematical modeling tools – quantitative evaluation. A qualitative assessment of electronic documentation of economic activity through exercise performance, efficiency of communication; document management efficiency; effectiveness of flow control operations; relationship management effectiveness. The concept of quality control process documents electronically economic activity to components which include: the level of workflow; forms adequacy of information; consumer quality documents; quality attributes; type of income data; condition monitoring systems; organizational level process documentation; attributes of quality, performance quality consumer; type of management system; type of income data; condition monitoring systems. Grounded components of the control system electronic document subjects of economic activity. Detected components IT-audit management system economic activity: compliance audit; audit of internal control; detailed multilevel analysis; corporate risk assessment methodology. The stages and methods of processing electronic transactions economic activity during condition monitoring of electronic economic activity.

  5. 十六味杜鹃花丸中丁香酚含量的GC测定法%Content measuring of eugenol as a quality control index in sixteen azalea pills by GC Method

    Institute of Scientific and Technical Information of China (English)

    王静; 岳秀峰

    2012-01-01

    [Objective]To establish the control index of intrinsic quality, and improve the drug quality standard. [Methods]The content of eugenol was determined by gas chromatography method. [Results] The content of eugenol showed good linear relationship in the range of 50-500 μg, the regression equation was Y = 1 215. 3 X- 42. 233, R = 1. 000, the average recovery ratio was 99.23% , RSD was 0.53%. [Conclusion]The method is simple, sensible and accurate, and the study has lay the foundation of further improving the drug quality standard.%目的 建立内在质量监控指标,提高药品质量标准.方法 采用气相色谱法测定丁香酚的含量.结果 丁香酚在50~500μg范围内呈良好线性关系,回归方程y=1215.3 X-42.233.R=1.000,平均回收率为99.23%,RSD为0.53%.结论 该方法简便、灵敏、准确,为进一步提高该药的质量标准打下了基础.

  6. 42 CFR 84.41 - Quality control plans; contents.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Quality control plans; contents. 84.41 Section 84... AND HEALTH RESEARCH AND RELATED ACTIVITIES APPROVAL OF RESPIRATORY PROTECTIVE DEVICES Quality Control § 84.41 Quality control plans; contents. (a) Each quality control plan shall contain provisions for...

  7. 30 CFR 28.30 - Quality control plans; filing requirements.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Quality control plans; filing requirements. 28... PROTECTION FOR TRAILING CABLES IN COAL MINES Quality Control § 28.30 Quality control plans; filing... part, each applicant shall file with MSHA a proposed quality control plan which shall be designed...

  8. 42 CFR 84.40 - Quality control plans; filing requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Quality control plans; filing requirements. 84.40... Control § 84.40 Quality control plans; filing requirements. As a part of each application for approval or... proposed quality control plan which shall be designed to assure the quality of respiratory...

  9. 21 CFR 211.22 - Responsibilities of quality control unit.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Responsibilities of quality control unit. 211.22... Personnel § 211.22 Responsibilities of quality control unit. (a) There shall be a quality control unit that... have been fully investigated. The quality control unit shall be responsible for approving or...

  10. Control of Perceptual Image Quality Based on PID for Streaming Video

    Institute of Scientific and Technical Information of China (English)

    SONG Jian-xin

    2003-01-01

    Constant levels of perceptual quality of streaming video is what ideall users expect. In most cases, however, they receive time-varying levels of quality of video. In this paper, the author proposes a new control method of perceptual quality in variable bit rate video encoding for streaming video. The image quality calculation based on the perception of human visual systems is presented. Quantization properties of DCT coefficients are analyzed to control effectively. Quantization scale factors are ascertained based on the visual mask effect. A Proportional Integral Difference ( PID ) controller is used to control the image quality. Experimental results show that this method improves the perceptual quality uniformity of encoded video.

  11. 40 CFR 75.21 - Quality assurance and quality control requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Quality assurance and quality control... assurance and quality control requirements. (a) Continuous emission monitoring systems. The owner or... system according to the quality assurance and quality control procedures in appendix B of this part....

  12. PEG化重组人促红素质量控制方法和标准研究%Study on methods and requirements for quality control of Pegylated Erythropoietin ( PEG-EPO)

    Institute of Scientific and Technical Information of China (English)

    周勇; 王丽; 于传飞; 杨鹏云; 王箐舟; 侯继锋; 王军志

    2012-01-01

    To establish methods and requirements for the quality control of PEG - EPO. Methods -.In vivo bioactivity of PEG - EPO was determined by the count of reticulocytes in normocythaemic mice. Isoforms were analyzed by cIEF. Oligosaccharide fingerprint profiling was determined by HPAEC. Purity and peptide mapping were analyzed by reverse HPLC system. Other routine tests were all carried out according to the Chinese pharmacopoeia (volume HI ,2010 edition). Results;The requirements and methods for the quality control of PEG - EPO have been established. The results of all tests were reliable and reproducible, and complied with the Chinese pharmacopoeia and guidelines for the quality control of recombinant DNA products. Conclusion;The methods and requirements for PEG - EPO showed the characteristics of assuring the products safety and efficacy, which can be used for the quality control of PEG - EPO.%目的:建立PEG化重组人促红素质量控制方法和质量标准.方法:用正常小鼠网织红细胞计数法测定体内生物学活性,使用iCE毛细管等电聚焦电泳分析异构体,用离子色谱确定N-糖链指纹图谱,反相HPLC进行Lys -C蛋白内切酶酶切的肽图分析以及纯度测定.其余检测项目按2010年版中国药典三部方法进行.结果:建立的方法经过比较和对PEG化重组人促红素的检测,结果稳定可靠,重复性好,各指标符合《人用重组DNA制品质量控制技术指导原则》和2010年版中国药典三部的要求.结论:本研究建立了一套完善的PEG化重组人促红素质量控制体系.

  13. Quality guaranteed aggregation based model predictive control and stability analysis

    Institute of Scientific and Technical Information of China (English)

    LI DeWei; XI YuGeng

    2009-01-01

    The input aggregation strategy can reduce the online computational burden of the model predictive controller. But generally aggregation based MPC controller may lead to poor control quality. Therefore, a new concept, equivalent aggregation, is proposed to guarantee the control quality of aggregation based MPC. From the general framework of input linear aggregation, the design methods of equivalent aggregation are developed for unconstrained and terminal zero constrained MPC, which guarantee the actual control inputs exactly to be equal to that of the original MPC. For constrained MPC, quasi-equivalent aggregation strategies are also discussed, aiming to make the difference between the control inputs of aggregation based MPC and original MPC as small as possible. The stability conditions are given for the quasi-equivalent aggregation based MPC as well.

  14. Control of Bank Consolidated Financial Statements Quality

    Directory of Open Access Journals (Sweden)

    Margarita S. Ambarchyan

    2013-01-01

    Full Text Available The author presents the multiple linear regression model of bank consolidated financial statements quality. The article considers six characteristics that can be used to estimate the level of bank consolidated financial statements quality. The multiple linear regression model was developed, using the results of point-based system of consolidated financial statements of thirty European bank and financial groups on the basis of the developed characteristics. The author offers to use the characteristic significance factor in the process of consolidated financial statements appraisal by points. The constructed regression model is checked on accuracy and statistical significance. The model can be used by internal auditors and financial analytics as an instrument for bank and non-bank consolidated financial statements quality control

  15. Application of list style quality control method in implementation and monitoring of care check%清单式质量控制方式在护理查对制度执行监控中的应用

    Institute of Scientific and Technical Information of China (English)

    董雪云; 马辉; 陆利生

    2014-01-01

    Objective:To probe into the effect of list style quality control method for improving the rates of nursing checking standard,and aiming at correcting bad habits appearing in nurses carrying out the checking system, therefore to improve the effective checking standard rates.Methods: According to the requirements of nursing check system,on site inspections were carried out for nurses in 17 different surgical wards in hospital in different time periods and different operational links of the implementation of check system,to know about the non standard check behaviors of nurses.Timely feedback the problems and make quality control check list of nursing check,supervising and guide by one level quality control personnel. Results:After applying list type of quality control monitoring,the non standardized rate decent to 8.24% from 54.12%,the difference was statistically significant(P <0.05).Conclusion:The list type of quality control way is conductive for quality control personnels grasping the quality control focuses,and it is helpful for nurses developing good checking habits and improving care and check standardized rate.%[目的]探讨清单式质量控制方式对提高护理查对规范率的作用,旨在及时纠正护士执行查对制度的不良习惯,从而提高有效查对率。[方法]根据护理查对制度的要求,实地检查本院外科17个病区的护士在不同时间段及不同操作环节查对制度执行情况,了解护士不规范的查对行为。对存在问题及时反馈并制作护理查对质量控制清单,由一级质量控制员进行监督和指导。[结果]应用清单式质量控制方式监控后护理查对不规范率由54.12%下降至8.24%,差异有统计学意义(P<0.05)。[结论]清单式质量控制方式有利于质量控制员把握质量控制重点,有助于护士养成良好的查对习惯,提高护理查对规范率。

  16. How to assess the quality of your analytical method?

    Science.gov (United States)

    Topic, Elizabeta; Nikolac, Nora; Panteghini, Mauro; Theodorsson, Elvar; Salvagno, Gian Luca; Miler, Marijana; Simundic, Ana-Maria; Infusino, Ilenia; Nordin, Gunnar; Westgard, Sten

    2015-10-01

    Laboratory medicine is amongst the fastest growing fields in medicine, crucial in diagnosis, support of prevention and in the monitoring of disease for individual patients and for the evaluation of treatment for populations of patients. Therefore, high quality and safety in laboratory testing has a prominent role in high-quality healthcare. Applied knowledge and competencies of professionals in laboratory medicine increases the clinical value of laboratory results by decreasing laboratory errors, increasing appropriate utilization of tests, and increasing cost effectiveness. This collective paper provides insights into how to validate the laboratory assays and assess the quality of methods. It is a synopsis of the lectures at the 15th European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Continuing Postgraduate Course in Clinical Chemistry and Laboratory Medicine entitled "How to assess the quality of your method?" (Zagreb, Croatia, 24-25 October 2015). The leading topics to be discussed include who, what and when to do in validation/verification of methods, verification of imprecision and bias, verification of reference intervals, verification of qualitative test procedures, verification of blood collection systems, comparability of results among methods and analytical systems, limit of detection, limit of quantification and limit of decision, how to assess the measurement uncertainty, the optimal use of Internal Quality Control and External Quality Assessment data, Six Sigma metrics, performance specifications, as well as biological variation. This article, which continues the annual tradition of collective papers from the EFLM continuing postgraduate courses in clinical chemistry and laboratory medicine, aims to provide further contributions by discussing the quality of laboratory methods and measurements and, at the same time, to offer continuing professional development to the attendees.

  17. Optimal control linear quadratic methods

    CERN Document Server

    Anderson, Brian D O

    2007-01-01

    This augmented edition of a respected text teaches the reader how to use linear quadratic Gaussian methods effectively for the design of control systems. It explores linear optimal control theory from an engineering viewpoint, with step-by-step explanations that show clearly how to make practical use of the material.The three-part treatment begins with the basic theory of the linear regulator/tracker for time-invariant and time-varying systems. The Hamilton-Jacobi equation is introduced using the Principle of Optimality, and the infinite-time problem is considered. The second part outlines the

  18. Method for controlling powertrain pumps

    Science.gov (United States)

    Sime, Karl Andrew; Spohn, Brian L; Demirovic, Besim; Martini, Ryan D; Miller, Jean Marie

    2013-10-22

    A method of controlling a pump supplying a fluid to a transmission includes sensing a requested power and an excess power for a powertrain. The requested power substantially meets the needs of the powertrain, while the excess power is not part of the requested power. The method includes sensing a triggering condition in response to the ability to convert the excess power into heat in the transmission, and determining that an operating temperature of the transmission is below a maximum. The method also includes determining a calibrated baseline and a dissipation command for the pump. The calibrated baseline command is configured to supply the fluid based upon the requested power, and the dissipation command is configured to supply additional fluid and consume the excess power with the pump. The method operates the pump at a combined command, which is equal to the calibrated baseline command plus the dissipation command.

  19. Mitochondrial quality control in cardiac diseases.

    Directory of Open Access Journals (Sweden)

    Juliane Campos

    2016-10-01

    Full Text Available Disruption of mitochondrial homeostasis is a hallmark of cardiac diseases. Therefore, maintenance of mitochondrial integrity through different surveillance mechanisms is critical for cardiomyocyte survival. In this review, we discuss the most recent findings on the central role of mitochondrial quality control processes including regulation of mitochondrial redox balance, aldehyde metabolism, proteostasis, dynamics and clearance in cardiac diseases, highlighting their potential as therapeutic targets.

  20. Microbiological Quality Control of Probiotic Products

    OpenAIRE

    Astashkina, Anna Pavlovna; Khudyakova, L. I.; Kolbysheva, Yuliya Vladimirovna

    2014-01-01

    Microbiological quality control of probiotic products such as Imunele, Dannon, Pomogayka showed that they contain living cultures of the Lactobacillus Bifidobacterium genus in the amount of 107 CFU/ml, which corresponds to the number indicated on the label of products. It is identified that the survival rate of test-strains cultured with pasteurized products does not exceed 10%. The cell concentration of target-microorganisms was reduced by 20-45% after the interaction with living probiotic b...

  1. Towards quality control of food using terahertz

    Science.gov (United States)

    Ung, B. S.-Y.; Fischer, B. M.; Ng, B. W.-H.; Abbott, D.

    2007-12-01

    Terahertz radiation or T-rays, show promise in quality control of food products. As T-rays are inherently sensitive to water, they are very suitable for moisture detection. This proves to be a valuable asset in detecting the moisture content of dried food, a critical area for some products. As T-rays are transparent to plastics, food additives can also be probed through the packaging, providing checks against a manufacturer's claims, such as the presence of certain substances in foods.

  2. Scatterscore method to evaluate changes in water quality

    Energy Technology Data Exchange (ETDEWEB)

    Kim, A.G.; Cardone, C. [U.S. Department of Energy, Pittsburgh, PA (United States). National Energy Technology Laboratory

    2001-07-01

    In Pennsylvania, water quality is monitored at mine sites remediated with coal combustion by-products (CCB), on a quarterly or annual basis. This produces extensive data files including values for 32 parameters that are difficult to evaluate for overall changes in water quality. Tracking a few major parameters, such as pH, Fe or acidity, produces a complex data set that excludes other significant values. A quantitative measure of estimating if the overall change in water quality is an improvement, no significant change or deterioration should take into account all measured quantities. To assess the change in water quality at a site, a scatterscore evaluation was developed. In this reconnaissance method, a score is calculated based on the differences between up gradient (control) versus down gradient (treatment) water quality data sets. All parameters measured over a period of time at two sampling points are compared. This evaluation method indicated that there was slight to moderate improvement in water quality at 30% of the CCB remediated sites and slight deterioration at 25% of the sites. The scatterscore at the remaining sites indicated random change in the measured parameters. 19 refs., 7 figs., 5 tabs.

  3. Towards a Standardised Method to Acquire and Store Liver Samples and Guidelines to Improve Quality Control and Exchange of Relative Expression Data

    Directory of Open Access Journals (Sweden)

    Frank M. Riemers

    2013-12-01

    Full Text Available The current ‘state-of-the-art’ molecular techniques are extremely sensitive and consequently prone to false results. Even more so than in the past, today’s hepatology research depends on high quality samples, especially for the molecular analyses. In all steps, starting with specimen sampling, fixation, storage, molecular processing and finally data calculation, variations in procedures between research laboratories may have a profound effect on the final conclusions. At the end of the day, this is an enormous drawback once data from different research institutes need to be reproduced, compared and/or combined. To improve standardisation, the so-called MIQE guidelines (Minimum Information for Publication of Quantitative Real- Time PCR Experiments were presented for quantitative PCR (qPCR studies.1,2 Furthermore, around the same time, recommendations were presented regarding human biospecimen collection, storage and processing, the so-called BRISQ-guidelines (Biospecimen Reporting for Improved Study Quality.3 Finally, the editors of The Journal of Pathology as well as Histopathology required in the December 2012 issue of The Journal of Pathology that researchers needed to follow the BRISQ guidelines in their papers in order to improve the sample quality in biomedical research.4 These initiatives hold great promise to improve the comparison and independent reproduction of data acquired in different research centres. Pancreas, gall bladder and liver research will especially benefit from the standardisation protocols since these organ systems are highly vulnerable to post-biopsy autolytic degradation. This comment illustrates that standardisation in molecular liver research is not yet at the point where experiments can be easily replicated, and data can be compared and combined.

  4. Empirical evaluation of humpback whale telomere length estimates; quality control and factors causing variability in the singleplex and multiplex qPCR methods

    DEFF Research Database (Denmark)

    Olsen, Morten Tange; Bérubé, Martine; Robbins, Jooke

    2012-01-01

    BACKGROUND:Telomeres, the protective cap of chromosomes, have emerged as powerful markers of biological age and life history in model and non-model species. The qPCR method for telomere length estimation is one of the most common methods for telomere length estimation, but has received recent cri...

  5. Empirical evaluation of humpback whale telomere length estimates : Quality control and factors causing variability in the singleplex and multiplex qPCR methods

    NARCIS (Netherlands)

    Olsen, Morten Tange; Berube, Martine; Robbins, Jooke; Palsboll, Per J.

    2012-01-01

    Background: Telomeres, the protective cap of chromosomes, have emerged as powerful markers of biological age and life history in model and non-model species. The qPCR method for telomere length estimation is one of the most common methods for telomere length estimation, but has received recent criti

  6. Empirical evaluation of humpback whale telomere length estimates; quality control and factors causing variability in the singleplex and multiplex qPCR methods

    NARCIS (Netherlands)

    Olsen, Morten Tange; Berube, Martine; Robbins, Jooke; Palsboll, Per J.

    2012-01-01

    Background: Telomeres, the protective cap of chromosomes, have emerged as powerful markers of biological age and life history in model and non-model species. The qPCR method for telomere length estimation is one of the most common methods for telomere length estimation, but has received recent criti

  7. 7 CFR 58.335 - Quality control tests.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Quality control tests. 58.335 Section 58.335... Procedures § 58.335 Quality control tests. All milk, cream and related products are subject to inspection for quality and condition throughout each processing operation. Quality control tests shall be made on...

  8. 7 CFR 58.928 - Quality control tests.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Quality control tests. 58.928 Section 58.928... Procedures § 58.928 Quality control tests. All dairy products and other ingredients shall be subject to inspection for quality and condition throughout each processing operation. Quality control tests shall...

  9. 7 CFR 58.642 - Quality control tests.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Quality control tests. 58.642 Section 58.642... Procedures § 58.642 Quality control tests. All mix ingredients shall be subject to inspection for quality and condition throughout each processing operation. Quality control tests shall be made on flow line samples...

  10. [Methodology, method, and quality of qualitative research].

    Science.gov (United States)

    Frommer, Jörg; Rennie, David L

    2006-05-01

    Over the last ten years qualitative research approaches have been increasingly recognized and applied to the fields of psychotherapy and psychosomatic medicine in German-speaking countries, although this development has lagged behind what has occurred at the same time in English-speaking countries. In the former, especially, a misunderstanding prevails that qualitative research methods are at best preliminary to real science. This misunderstanding has roots in the philosophy of science and the sociology of knowledge. It comes from the lack of recognition that the human sciences, unlike the natural sciences, entail a double rather than single hermeneutic and that qualitative research methods are logically coherent ways of working systematically and rigorously with this double hermeneutic. Indeed, this nature of qualitative research is generally not well understood by many qualitative researchers themselves. In this article, the need for qualitative research is shown and its methodology is seen as an integration of method and hermeneutics, or methodical hermeneutics, which in turn is distinguished from alternative qualitative research methodologies. The article closes with considerations of quality criteria and publication standards.

  11. Internal quality control of sperm concentrations in semen analysis: Establishment of a method%精液分析中精子浓度室内质量控制方法的研究

    Institute of Scientific and Technical Information of China (English)

    高选; 刘晓丹; 赵丽娟; 卢少明; 郑大伟; 马金龙

    2012-01-01

    目的:建立一种可行的精子浓度检测的室内质控方法.方法:设定20×106和80×106两种浓度的冷冻精液作为高、低值室内质控品(IQC),QC-BEADSTM质控珠(以下简称质控珠)作为对照.采用双盲法,4名技术员分别通过计算机辅助精液分析(CASA)对上述假定的室内质控品及质控珠进行精子浓度的测定,绘制出各自的质控图( Xbar图和Sbar图),连续检测1个月,计算出相应的高、低浓度值批内及批间变异系数(CV%),并进行比较.结果:①假定室内质控品高、低值批内变异系数分别CV3.5%,CV2.4%;批间分别为CV10.2%、CV9.6%.质控珠高、低值批内分别为CV5.1%,CV7.1%,批间分别CV7.1%,CV8.2%.两组高、低值的批内变异均<10%,批间变异均<15%,符合(Levey-Jennings)L-J质量控制原则,均能达到室内质控目的.②两组间高、低值的批内变异系数及批间变异系数无显著性差异(P>0.05),提示假定质控品可代替质控珠行实验室内部质量控制.结论:我们建立的精子浓度测定的室内质控方法是简单、易行、可靠.%Objective: To establish a method for internal quality control (IQC) of sperm concentration test in the laboratory. Methods: We set the concentrations of frozen semen at 20 x 106 and 80 x 106 as low and high concentrations of putative IQC products, with QC-BEADSTM quality control beads (QCBs) as the control. Using the double-blind method, four technicians determined the sperm concentrations of the IQC products and QCBs by computer-assisted sperm analysis, and drew a quality control chart (Xbar chart and Sbar chart) for each product. Through a month of continuous detection, we calculated and compared the intra- and inter-batch coefficients of variation (CV% ) of the quality control products of high and low concentrations. Results: The intra-batch coefficients of variation of the assumed IQC products of high and low concentrations were CV3.5% and CV2.4% , and

  12. Applying GPS to check horizontal control quality

    Directory of Open Access Journals (Sweden)

    Jakub Vincent

    2004-03-01

    Full Text Available GPS technologies can also be used for check quality in available horizontal point set with coordinates CJ of the frame S-JTSK. When survey and setting-out tasks should be performed in certain area, one can found in it allways some points of the fundamental and detail state controls. To use these points for some actual aims, it is necessary to investigate their compatibility (among the point mark positions and the point coordinate of control points. This can be done using GPS surveying that may be at the same time employed to determine the new point in the relevant area.Principle of quality investigatingf an existing control is founded on determination of point coordinates CJt from GPS measurements. Then, based on discrepancies among the "official" netpoint coordinates CJ and coordinates CJt "given by GPS", it can be estimated the degree and the real compatibility dislocations in the network structure of the existing points.Realisation procedure for the introduced investigation is demonstrated on GPS checking (by SOKKIA STRATUS receivers horizontal control for reconstruction of a railway bridge on river Bodrog in East Slovakia.It can be shown from the results in Table 3, that points P3 and P7 are useless due to their incompatibility (inconsistency in the inspected point set. For other 7 points (Table 7 the average measure of incompatibility reads 9.8 mm that make possible applying these points for precise setting-out

  13. Development of new analytical methods using Near Infrared and Chemometrics for pharmaceutical quality control: Enhancement of modelling strategies towards a better product understanding

    OpenAIRE

    2015-01-01

    Obtener una alta calidad en la industria farmacéutica es un reto constante que requiere un estricto control y supervisión de los productos manufacturados. La tecnología analítica de procesos (PAT, Process Analytical Technology) propone que esto puede lograrse de una manera óptima y sistematizada mediante el control de calidad en diferentes etapas de manufactura (materias primas, intermedios y producto acabado). La simplicidad y rapidez de la espectroscopía de infrarrojo cercano (NIRS, Near In...

  14. Quality Control of Observation Data by the Geomagnetic Network of China

    OpenAIRE

    Suqin Zhang; Changhua Fu; Yufei He; Dongmei Yang; Qi Li; Xudong Zhao; Jianjun Wang

    2016-01-01

    Data quality is an important guarantee for scientific research. The Geomagnetic Network of China (GNC) controls data quality for all observatories under the jurisdiction of China Earthquake Administration. This paper presents the quality control content and methods; quality evaluation and feedback procedures; and the process for publishing data sets via the GNC website. Technical challenges and proposed quality assurance procedures for future GNC data sets are described.

  15. Adaptive quality control for multimedia communications

    Directory of Open Access Journals (Sweden)

    Santichai Chuaywong

    2008-01-01

    Full Text Available Multimedia communications are communications with several types of media, such as audio, video and data. The current Internet has some levels of capability to support multimedia communications, unfortunately, the QoS (Quality of Service is still challenging. A large number of QoS mechanisms has been proposed; however, the main concern is for low levels, e.g. layer 2 (Data Link or 3 (Transport. In this paper, mechanisms for control the quality of audio and video are proposed. G.723.1 and MPEG-4 are used as the audio and video codec respectively. The proposed algorithm for adaptive quality control of audio communication is based on forward error correction (FEC. In the case of video communication, the proposed algorithm adapts the value of key frame interval, which is an encoding parameter of MPEG-4. We evaluated our proposed algorithms by computer simulation. We have shown that, in most cases, the proposed scheme gained a higher throughput compared to other schemes.

  16. Quality Management of CERN Vacuum Controls

    CERN Document Server

    Antoniotti, F; Fortescue-Beck, E; Gama, J; Gomes, P; Le Roux, P; Pereira, H; Pigny, G

    2014-01-01

    The vacuum controls Section (TE-VSC-ICM) is in charge of the monitoring, maintenance and consolidation of the control systems of all accelerators and detectors in CERN; this represents 6 000 instruments distributed along 128 km of vacuum chambers, often of heterogeneous architectures and of diverse technical generations. In order to improve the efficiency of the services provided by ICM, to vacuum experts and to accelerator operators, a Quality Management Plan is being put into place. The first step was the standardization of the naming convention across different accelerators. The traceability of problems, requests, repairs, and other actions, has also been put into place (VTL). This was combined with the effort to identify each individual device by a coded label, and register it in a central database (MTF). Occurring in parallel, was the gathering of old documents and the centralization of information concerning architectures, procedures, equipment and settings (EDMS). To describe the topology of control c...

  17. The Application of Quantitative Statistics Method in Lab Quality Control%定量统计方法在实验室质量控制中的应用

    Institute of Scientific and Technical Information of China (English)

    周颖红; 郭仁宏; 梁莹

    2012-01-01

    This paper introduces the quantitative method for inter-lab test data analysis. Specifically, we elucidates by several living examples the implication of some commonly-used statistics method used for data analysis in lab quality control. Especially, we try to introduce the usage of statistical software, EXCEL in analyzing data.%阐述了实验室质量控制中常用的比对试验的数据分析方法,采用实例介绍定量统计方法在实验室质量控制数据分析中的应用,特别是利用计算机EXCEL统计软件进行质量控制数据分析的方法。

  18. 浅谈连续流动分析法测定总氮的质量控制%Discussion on the Quality Control of the Total Nitrogen Determination with Continuous Flow Analysis Method

    Institute of Scientific and Technical Information of China (English)

    施新锋

    2012-01-01

    Continuous flow analysis method for determination of total nitrogen has been a wide range of applications in the environmental monitoring system, according to the characteristics of the continuous flow analyzer, as well as on the determinate particularity of total nitrogen, the paper summarize quality control ieqnirements of total nitrogen determination with continuous flow analysis method.%连续流动分析测定总氮在环境监测系统得到了广范应用,本文根据连续流动分析仪的特点以及在测定总氮项目上的特殊性,归纳总结了连续流动分析测定总氮的质量控制要求。

  19. Data quality assurance in monitoring of wastewater quality: Univariate on-line and off-line methods

    DEFF Research Database (Denmark)

    Alferes, J.; Poirier, P.; Lamaire-Chad, C.;

    To make water quality monitoring networks useful for practice, the automation of data collection and data validation still represents an important challenge. Efficient monitoring depends on careful quality control and quality assessment. With a practical orientation a data quality assurance...... procedure is presented that combines univariate off-line and on-line methods to assess water quality sensors and to detect and replace doubtful data. While the off-line concept uses control charts for quality control, the on-line methods aim at outlier and fault detection by using autoregressive models....... The proposed tools were successfully tested with data sets collected at the inlet of a primary clarifier,where probably the toughest measurement conditions are found in wastewater treatment plants....

  20. Comparison of Three Control Methods in Penetration Control of Pulsed Gas Tungsten Arc Welding

    Institute of Scientific and Technical Information of China (English)

    陈文杰; 陈善本; 林涛

    2003-01-01

    An artificial neural network model for backside bead width was established and three control meth-ods PID, fuzzy and neuron were designed, simulated and tested. The test results of bead-on-plate weld ofGTAW indicate that the artificial neural network (ANN) modeling and learning control method have more advan-tages than the conventional method. They show that the ANN modeling and learning control method is an effectiveapproach to real time control of welding dynamics and ideal quality.

  1. Process control and optimization with simple interval calculation method

    DEFF Research Database (Denmark)

    Pomerantsev, A.; Rodionova, O.; Høskuldsson, Agnar

    2006-01-01

    the series of expanding PLS/SIC models in order to support the on-line process improvements. This method helps to predict the effect of planned actions on the product quality and thus enables passive quality control. We have also considered an optimization approach that proposes the correcting actions......Methods of process control and optimization are presented and illustrated with a real world example. The optimization methods are based on the PLS block modeling as well as on the simple interval calculation methods of interval prediction and object status classification. It is proposed to employ...... for the quality improvement in the course of production. The latter is an active quality optimization, which takes into account the actual history of the process. The advocate approach is allied to the conventional method of multivariate statistical process control (MSPC) as it also employs the historical process...

  2. Method for synthesis of high quality graphene

    Science.gov (United States)

    Lanzara, Alessandra [Piedmont, CA; Schmid, Andreas K [Berkeley, CA; Yu, Xiaozhu [Berkeley, CA; Hwang, Choonkyu [Albany, CA; Kohl, Annemarie [Beneditkbeuern, DE; Jozwiak, Chris M [Oakland, CA

    2012-03-27

    A method is described herein for the providing of high quality graphene layers on silicon carbide wafers in a thermal process. With two wafers facing each other in close proximity, in a first vacuum heating stage, while maintained at a vacuum of around 10.sup.-6 Torr, the wafer temperature is raised to about 1500.degree. C., whereby silicon evaporates from the wafer leaving a carbon rich surface, the evaporated silicon trapped in the gap between the wafers, such that the higher vapor pressure of silicon above each of the wafers suppresses further silicon evaporation. As the temperature of the wafers is raised to about 1530.degree. C. or more, the carbon atoms self assemble themselves into graphene.

  3. Methanol tailgas combustor control method

    Science.gov (United States)

    Hart-Predmore, David J.; Pettit, William H.

    2002-01-01

    A method for controlling the power and temperature and fuel source of a combustor in a fuel cell apparatus to supply heat to a fuel processor where the combustor has dual fuel inlet streams including a first fuel stream, and a second fuel stream of anode effluent from the fuel cell and reformate from the fuel processor. In all operating modes, an enthalpy balance is determined by regulating the amount of the first and/or second fuel streams and the quantity of the first air flow stream to support fuel processor power requirements.

  4. 调味品微生物检验的质量控制与方法%Quality control and method of condiment microbiological analysis

    Institute of Scientific and Technical Information of China (English)

    周静

    2010-01-01

    引起调味品霉变、腐败,进而造成食物中毒和食源性疾病的可能性有多种,其中重要的一个原因就是微生物,调味品微生物检验的目的就是为了监督调味品生产,保障调味品的食用安全.同时参照HACCP体系的要求在调味品微生物检验过程中建立质量评价点(Quality Assessment Points,QAP),在每一个评价点实施质量控制,从而形成调味品微生物检验质量保证体系,以保证各项检验结果准确可靠.文章根据实际工作中存在的问题,讨论调味品微生物检验的质量控制和方法.

  5. A step forward in the quality control testing of inactivated rabies vaccines - extensive evaluation of European vaccines by using alternative methods to the in vivo potency tests.

    Science.gov (United States)

    Servat, Alexandre; Kempff, Sébastien; Brogat, Valère; Litaize, Estelle; Schereffer, Jean-Luc; Cliquet, Florence

    2015-03-01

    The mouse challenge test still remains the reference method for the potency determination of human and animal inactivated rabies vaccines, and it is still widely used throughout the world. This test suffers from many disadvantages - it is expensive and time consuming, uses a large number of mice, causes significant animal distress, and suffers from high variability. Recently, the European Pharmacopoeia has recognised the use of a serological potency assay (SPA) as an alternative method to the challenge test. This new test is based on the determination of rabies neutralising antibody titres in vaccinated mice, by using the modified Rapid Fluorescent Focus Inhibition Test (mRFFIT). With the objective of adopting this new method for the batch release of inactivated rabies vaccines, we evaluated its performance on a large collection of rabies vaccines currently assessed in our laboratory. The Fluorescent Antibody Virus Neutralisation test (FAVNt) was used in parallel with the mRFFIT, and the results were compared to the mouse challenge test. Our results demonstrate that the SPA is capable of estimating the potency of vaccines formulated with a potency margin well above the minimum of 1IU/dose. For low potency vaccines, this new method demonstrated some limitations, due to the recurrent invalidation of the assay. We have also demonstrated the superior sensitivity of the FAVNt when compared to the mRFFIT, and the importance of minimising the risk of detecting non-responders in vaccinated mice. 2015 FRAME.

  6. The importance of quality control in validating concentrations ...

    Science.gov (United States)

    A national-scale survey of 247 contaminants of emerging concern (CECs), including organic and inorganic chemical compounds, and microbial contaminants, was conducted in source and treated drinking water samples from 25 treatment plants across the United States. Multiple methods were used to determine these CECs, including six analytical methods to measure 174 pharmaceuticals, personal care products, and pesticides. A three-component quality assurance/quality control (QA/QC) program was designed for the subset of 174 CECs which allowed us to assess and compare performances of the methods used. The three components included: 1) a common field QA/QC protocol and sample design, 2) individual investigator-developed method-specific QA/QC protocols, and 3) a suite of 46 method comparison analytes that were determined in two or more analytical methods. Overall method performance for the 174 organic chemical CECs was assessed by comparing spiked recoveries in reagent, source, and treated water over a two-year period. In addition to the 247 CECs reported in the larger drinking water study, another 48 pharmaceutical compounds measured did not consistently meet predetermined quality standards. Methodologies that did not seem suitable for these analytes are overviewed. The need to exclude analytes based on method performance demonstrates the importance of additional QA/QC protocols. This paper compares the method performance of six analytical methods used to measure 174 emer

  7. Quality control in exascale data archives

    Science.gov (United States)

    Juckes, Martin

    2013-04-01

    Quality control of data can and should occur at many stages of the data life cycle. Data producers will generally conduct their own tests prior to release of data. Further tests may be done by within consortium projects, by archive centres or, after publication of the data, by independent investigators. The results of such tests are often used only by the individual or group carrying out the tests. Sharing of quality control information is restricted by many factors: this presentation addresses the lack of a common terminology to define quality control tests. A framework is proposed, based on abstract tests (e.g. a "prescribed range test"), specific tests (e.g. "variable tas is in the range 200-350K") and test results. Test results also need to be linked to the data robustly to ensure that they are available at all subsequent stages of the data lifecycle, and the appropriate mechanisms of linkage will differ at different stages of the lifecycle. The framework should support references to the data from the test results, references to the results from the data or discovery by association. Performing tests may generate useful by-products (e.g. the maximum and minimum values of the data): these ancillary results should be stored and made accessible with test results. In many cases tests will refer to multiple files, and groups of tests will be of more interest than individual tests. Mechanisms for describing tests suites will be discussed with particular reference to the challenges of applying tests to climate model data.

  8. [ROKO--computer-assisted roentgen quality control].

    Science.gov (United States)

    Schenk, G; Gfirtner, H

    1995-05-01

    To guarantee the quality of 30 x-ray machines and 8 photographic processors 24,000 data are collected yearly. A computer system is introduced (ROKO-Röntgenkonstanzprüfung) which helps to collect the monthly data easily and to measure on-line dose and voltage. If given tolerance values are exceeded acoustic and graphic warnings appear, a trend analysis is made to assure the correctness of the collected data, a generator to design the layout of check form facilitates the controlling and an on-line documentation for each x-ray machine is available. All these features help save time and money.

  9. Ultra-fast gradient LC method for omeprazole analysis using a monolithic column: assay development, validation, and application to the quality control of omeprazole enteric-coated pellets.

    Science.gov (United States)

    Borges, Keyller Bastos; Sánchez, Antonio José Macías; Pupo, Mônica Tallarico; Bonato, Pierina Sueli; Collado, Isidro González

    2010-01-01

    A method was optimized for the analysis of omeprazole (OMZ) by ultra-high speed LC with diode array detection using a monolithic Chromolith Fast Gradient RP 18 endcapped column (50 x 2.0 mm id). The analyses were performed at 30 degrees C using a mobile phase consisting of 0.15% (v/v) trifluoroacetic acid (TFA) in water (solvent A) and 0.15% (v/v) TFA in acetonitrile (solvent B) under a linear gradient of 5 to 90% B in 1 min at a flow rate of 1.0 mL/min and detection at 220 nm. Under these conditions, OMZ retention time was approximately 0.74 min. Validation parameters, such as selectivity, linearity, precision, accuracy, and robustness, showed results within the acceptable criteria. The method developed was successfully applied to OMZ enteric-coated pellets, showing that this assay can be used in the pharmaceutical industry for routine QC analysis. Moreover, the analytical conditions established allow for the simultaneous analysis of OMZ metabolites, 5-hydroxyomeprazole and omeprazole sulfone, in the same run, showing that this method can be extended to other matrixes with adequate procedures for sample preparation.

  10. A system framework of inter-enterprise machining quality control based on fractal theory

    Science.gov (United States)

    Zhao, Liping; Qin, Yongtao; Yao, Yiyong; Yan, Peng

    2014-03-01

    In order to meet the quality control requirement of dynamic and complicated product machining processes among enterprises, a system framework of inter-enterprise machining quality control based on fractal was proposed. In this system framework, the fractal-specific characteristic of inter-enterprise machining quality control function was analysed, and the model of inter-enterprise machining quality control was constructed by the nature of fractal structures. Furthermore, the goal-driven strategy of inter-enterprise quality control and the dynamic organisation strategy of inter-enterprise quality improvement were constructed by the characteristic analysis on this model. In addition, the architecture of inter-enterprise machining quality control based on fractal was established by means of Web service. Finally, a case study for application was presented. The result showed that the proposed method was available, and could provide guidance for quality control and support for product reliability in inter-enterprise machining processes.

  11. 影响葵花籽(仁)品质变化的因素及控制方法%Factors affected sunflower seeds (kernel) quality and control methods

    Institute of Scientific and Technical Information of China (English)

    姚云游; 姚玮

    2014-01-01

    Influencing factors of the quality changes of sunflower seeds ( kernel) during storage were re-searched. The effects of air, sunlight, temperature, moisture, impurity and sunflower seeds ( kernel) in-tact on quality changes of sunflower seeds ( kernel) during storage were studied. The method for control-ling or eliminating adverse influencing factors including the anti-sun, anti-moisture, moisture reduc-tion, improvement of intact rate, reductions of fragmentation rate and impurity content, plastic film sealed storage, short storage time were explored.%研究分析了葵花籽(仁)在储藏期间品质变化的影响因素。从空气、光照、温度、水分、杂质以及葵花籽(仁)完好程度6个方面对葵花籽(仁)在储藏期间品质变化的影响进行了研究。从防日晒、防潮湿、降低含水量、提高出成率、降低破碎率、降低杂质含量、采用塑料薄膜密闭储藏、缩短储藏时间方面探讨了控制或消除这些不利影响因素的方法。

  12. Evaluation of analytical performance and comparison of clinical results of the new generation method AccuTnI+3 for the measurement of cardiac troponin I using both patients and quality control plasma samples.

    Science.gov (United States)

    Storti, Simona; Masotti, Silvia; Prontera, Concetta; Franzini, Maria; Buzzi, Paola; Casagranda, Ivo; Ciofini, Enrica; Zucchelli, Gian Carlo; Ndreu, Rudina; Passino, Claudio; Clerico, Aldo

    2015-12-07

    The study aims are to evaluate the analytical performance and the clinical results of the chemiluminescent Access AccuTnI+3 immunoassay for the determination of cardiac troponin I (cTnI) with DxI 800 and Access2 platforms and to compare the clinical results obtained with this method with those of three cTnI immunoassays, recently introduced in the European market. The limits of blank (LoB), detection (LoD), and quantitation (LoQ) at 20% CV and 10% CV were 4.5 ng/L and 10.9 ng/L, 17.1 and 30.4 ng/L, respectively. The results of STAT Architect high Sensitive TnI (Abbott Diagnostics), ADVIA Centaur Troponin I Ultra (Siemens Healthcare Diagnostics), ST AIA-Pack cTnI third generation (Tosoh Bioscience), and Access AccuTnI+3 (Beckman Coulter Diagnostics) showed very close correlations (R ranging from 0.901 to 0.994) in 122 samples of patients admitted to the emergency department. However, on average there was a difference up to 2.4-fold between the method measuring the highest (ADVIA method) and lowest cTnI values (AccuTnI+3 method). The consensus mean values between methods ranged from 6.2% to 29.6% in 18 quality control samples distributed in an external quality control study (cTnI concentrations ranging from 29.3 ng/L to 1557.5 ng/L). In conclusion, the results of our analytical evaluation concerning the AccuTnI+3 method, using the DxI platform, are well in agreement with those suggested by the manufacturer as well as those reported by some recent studies using the Access2 platform. Our results confirm that the AccuTnI+3 method for the Access2 and DxI 800 platforms is a clinically usable method for cTnI measurement.

  13. A Study on Power Quality Improvement in PWM Controlled AC Voltage Controller

    Directory of Open Access Journals (Sweden)

    Ahmet ALTINTAŞ

    2009-04-01

    Full Text Available A lot of topologies of pulse-width modulated (PWM-AC controllers for single-phase and three-phase systems are proposed up to date. PWM-AC controllers have important advantages compared with the phase-controlled AC controllers using thyristors and triacs. The PWM-AC controller has sinusoidal current waveforms, smaller THD values, better power factor, faster dynamics, and smaller input/output filter. This article presents a novel control technique for application to PWM-AC controllers with ability of generating fewer harmonics. In the proposed control method, both the traditional AC voltage controllers and the PWM-AC controllers are combined; and smaller THD values are obtained. Thus, the harmonic pollution in the power system will be reduced; and consequently, the power quality will be increased. For this purpose, computer simulations are performed in order to investigate the proposed controller performance. The obtained results are compared with the conventional PWM-AC controller.

  14. 不同发酵时间对樟帮枳壳饮片质量的影响%Quality Control Method of Citrus anrantium Pieces with Different Fermentation Time

    Institute of Scientific and Technical Information of China (English)

    方小华; 谢一辉; 姚冬琴; 何敏; 龚千锋; 张金莲

    2012-01-01

    Objective: To explore quality control method of Citrus anrantium pieces with different fermentation time. Method; Taking C. anrantium with different fermentation time as object, camera and Adobe Photoshop software were used to obtain basic information of pieces color, the content of naringin and neohesperidin in pieces were determined by HPLC. Information of pieces color and relationship of active ingredients were analyzed by SPSS 13.0. Result; There was a significant correlation between color differenceand active ingredients. Conclusion; Color difference could be used as one index of quality criteria for C. Anrantium with different fermentation time.%目的:探讨不同发酵时间对樟帮枳壳饮片质量的影响.方法:以不同发酵时间樟帮枳壳饮片为研究对象,用照相机和Adobe Photoshop软件获取各饮片色泽的基本信息,采用HPLC测定饮片中柚皮苷和新橙皮苷的含量,SPSS 13.0统计软件对饮片色泽信息和有效成分的关系进行分析.结果:色度差和有效成分存在显著相关性.结论:色度差可作为不同发酵时间樟帮枳壳饮片质量评判标准的指标之一.

  15. Five Librarians Talk about Quality Control and the OCLC Database.

    Science.gov (United States)

    Helge, Brian; And Others

    1987-01-01

    Five librarians considered authorities on quality cataloging in the OCLC Online Union Catalog were interviewed to obtain their views on the current level of quality control in the OCLC database, the responsibilities of OCLC and individual libraries in improving the quality of records, and the consequences of quality control problems. (CLB)

  16. 7 CFR 58.141 - Alternate quality control program.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Alternate quality control program. 58.141 Section 58... Service 1 Quality Specifications for Raw Milk § 58.141 Alternate quality control program. When a plant has in operation an acceptable quality program, at the producer level, which is approved by...

  17. USE OF INTELLECTUAL TECHNOLOGIES FOR QUALITY CONTROL OF CURD

    Directory of Open Access Journals (Sweden)

    M. M. Blagoveshchenskaia

    2014-01-01

    Full Text Available Summary. Method of curds quality control, based on neural network model is introduced in the paper. It allows to give fair estimate of final product’s quality without use of professional degustators. Method consists in construction of neural network model to estimate quality of curds by input and output parameters. Hardware software complex of curds taste control is proposed to apply in industry for independent estimate of final product. Operation of neural network model based on usage of artificial neural networks, which is one of directions of artificial intelligence theory. Neural network model consists of several artificial neurons layers, which emulate nerve cells functioning. Feed forward network of MLP type was used in solving of curds taste control problem. Feature of this network is that signals passed from one layer’s neurons to next layer’s neurons only from input layer to output, not the other way. Neural network was trained for its correct operation by selection of optimal synaptic factors. Flow diagram of training algorithm is introduced in the paper. Algorithm of neural network tuning is described in the paper. Author proposed set of recommendations for software-hardware complex deployment. Experiment results show that this taste estimate method based on neural net works simplify a problem of final product control as allow to react to deviations in production process on proper time.

  18. 间接法氧化锌质量控制探析%The Indirect Method Zinc Oxide Quality Control Mainly

    Institute of Scientific and Technical Information of China (English)

    夏立新

    2013-01-01

    Zinc oxide as a material of application range is very wide, the material performance is strong, at the same time, its application range is very wide. In this paper, the preparation process of the indirect method zinc oxide process and characteris-tics of zinc oxide, and their advantages and disadvantages are objectively pointed out that the zinc oxide, and finally prospects of zinc oxide in the future in the application were discussed.%  氧化锌作为一种应用广泛的材料,其性能非常强大。文章介绍氧化锌间接法工艺的制备过程及氧化锌特点,同时客观地指出氧化锌的优缺点,最后对氧化锌未来的应用前景进行探讨。

  19. Quality control of laser tailor welded blanks

    Science.gov (United States)

    Yan, Qi

    2008-03-01

    Tailor welded blanks were widely used in the automobile industry for their special advantages. A combination of different materials, thickness, and coatings could be welded together to form a blank for stamping car body panels. With the gradually growing consciousness on safety requirement of auto body structural, the business of laser tailor welded blanks is developing rapidly in China. Laser tailor welded blanks were just the semi products between steel factory and automobile manufacturers. As to the laser welding defects such as convexity and concavity, automobile industry had the strict requirement. In this paper, quality standard on laser tailor welded blanks were discussed. As for the production of laser tailor welded blanks, online quality control of laser tailor welded blanks was introduced. The image processing system for welding laser positioning and weld seam monitoring were used in the production of laser tailor welded blanks. The system analyzes images from the individual cameras and transmits the results to the machine control system via a CAN bus.

  20. Quality control for invasive cardiology: Holland.

    Science.gov (United States)

    Plokker, H W

    1996-10-01

    Although no official registration of indications, treatments and results in patients with coronary heart disease has taken place in Holland, the following authorities and commissions have introduced guidelines for quality control: the Dutch government, the Dutch Society of Cardiology, the Working Group on Interventional Cardiology and the health insurers. Until 1991, the right to perform coronary interventions was tied to a license issued by the Ministry of Health. New recommendations were delineated 5 years ago: at least 500 interventions must be annually performed by 5 interventional cardiologists, i.e. ca. 100 interventions annually per cardiologist. No interventional cardiology may be performed without an in-house cardiac surgery and vice versa. In a survey by the Dutch Society of Cardiology on the quality of the Dutch centers, PTCA-mortality was ca. 0.3%, infarction rate was ca. 2%. An emergency bypass operation was necessary in 1.0 to 1.6% of the cases; the surgical team was on immediate alert for 11% of the patients. Selection of patients without risk was deemed impossible. Despite objections by some members the Dutch Society of Cardiology, it was recommended that cardiac surgery and interventions should not be separated. Data from health insurers showed no inappropriate indications for PTCA. The DUCAT-study, which used the RAND criteria, showed PTCA indications to be correct in more than 90% of the cases. The Dutch government wants to control the expansion of PTCA centers, so it is no wonder that waiting lists are becoming longer.

  1. Quality control parameters for Tamra (copper) Bhasma.

    Science.gov (United States)

    Jagtap, Chandrashekhar Yuvaraj; Prajapati, Pradeepkumar; Patgiri, Biswajyoti; Shukla, Vinay J

    2012-04-01

    Metallic Bhasmas are highly valued and have their own importance in Ayurvedic formulations. To testify the Bhasmas various parameters have been told in Rasashastra classics. Tamra Bhasma (TB) with its different properties is used in the treatment of various diseases is quiet famous among the Ayurvedic physicians (Vaidyas). The present study was carried out to set up the quality control parameters for the TB by making the use of classical tests along with advanced analytical tools. Copper wire taken for the preparation of Bhasma was first analyzed for its copper content and then subjected to Shodhana, Marana and Amrutikarana procedures as per the classical references. Final product complied with all the classical parameters like Rekhapurnatwa, Varitaratwa etc. After complying with these tests TB was analyzed by advanced analytical techniques like particle size distribution (PSD) analysis, scanning electron microscopy (SEM), and inductive coupled plasma spectrometry (ICP). PSD analysis of TB showed volumetric mean diameter of 28.70 μm, 50% of the material was below 18.40 μm size. Particle size less than 2μm were seen in SEM. 56.24 wt % of copper and 23.06 wt % of sulphur was found in ICP-AES. Heavy metals like cadmium, selenium were not detected while others like arsenic, lead and mercury were present in traces. These observations could be specified as the quality control parameters conforming to all the classical tests under the Bhasma Pariksha.

  2. [Controllability pyramid: an integrated control system of quality for traditional Chinese medicines].

    Science.gov (United States)

    Xiao, Xiao-He; Zhang, Ding-Kun; Wang, Jia-Bo; Yang, Ming; Peng, Cheng

    2015-01-01

    Quality control is one of the key scientific tissues in the modernization of traditional Chinese medicines (TCM). In order to overcome the deficiencies of assessment indexes, including little systematization and quantification, as well as loose association with clinical efficacy and dosage, a new integrated method named controllability pyramid ( CP) is first proposed in this paper. In addition, some study cases are used to explain how this model is constructed. We hope the establishment of CP could promote the clinical-orien- ted integrated innovation research of TCM, and provide control strategy and technology examples for improving the quality of Chinese medicines and clinical efficacy.

  3. ELISA 方法筛查 TORCH 感染的质量控制方法探讨%Study on quality control of ELISA method for screening TORCH infection

    Institute of Scientific and Technical Information of China (English)

    迟绍琴; 陈奕微; 师宏词; 孙宇飞; 郑立新

    2015-01-01

    目的:探讨实验室定性检测TORCH感染指标(风疹病毒IgG、巨细胞病毒IgG和IgM、弓形虫IgG和IgM ,简称五项)的室内质量控制方法。方法采用统计学方法,正态分布数据,用ELISA方法检测的阳性率比值和标准差,设定1+2s为失控规则,绘制半Lerey‐Jennings质控图;非正态分布数据、小概率事件,则采用直接概率计算法,回顾分析57批次的检测数据。结果风疹病毒IgG阳性率为86.66%、巨细胞病毒 IgG/IgM 的阳性率为98.87%和0.13%、弓形虫 IgG/IgM 阳性率为2.43%和1.71%,五项指标在临界值范围的分别有151、3、5、176、27个标本数据。失控次数为巨细胞病毒IgG 1次,弓形虫IgG/IgM 分别是1次和4次。结论 ELISA定性检测TORCH感染指标的室内质控,可以采用日常检测阳性率或阴性率数据监控假阳性。临界值范围的标本应当进一步复检或确认实验。%Objective Onto investigate the indoor quality control method for qualitatively detecting the laboratory indicators of TORCH infection (rubella virus IgG ,cytomegalovirus IgG and IgM ,toxoplasma IgG and IgM ) .Methods The statistical method , normal distribution data ,ratio and standard deviation of positive rate detected by the ELISA method were adopted ,1+2s was set as the out of control rules ,the semi Lerey‐Jennings quality control chart was drawn;the direct probability calculation method was a‐dopted for the non‐normal distribution data and small probability event .The testing data of 57 batches were retrospectively ana‐lyzed .Results The positive rate of rubella virus IgG was 86 .66% ,cytomegalovirus IgG/IgM positive rates were 98 .87% and 0 .13% ,toxoplasma gondii IgG/IgM positive rates were 2 .43% and 1 .71% ,the data of 151 ,3 ,5 ,176 ,27 samples had the critical value range of five indicators .The number of out of control was once for cytomegalovirus IgG ,once and 4 times for Toxoplasma

  4. Sap flow sensors: construction, quality control and comparison.

    Science.gov (United States)

    Davis, Tyler W; Kuo, Chen-Min; Liang, Xu; Yu, Pao-Shan

    2012-01-01

    This work provides a design for two types of sensors, based on the thermal dissipation and heat ratio methods of sap flow calculation, for moderate to large scale deployments for the purpose of monitoring tree transpiration. These designs include a procedure for making these sensors, a quality control method for the final products, and a complete list of components with vendors and pricing information. Both sensor designs were field tested alongside a commercial sap flow sensor to assess their performance and show the importance for quality controlling the sensor outputs. Results show that for roughly 2% of the cost of commercial sensors, self-made sap flow sensors can provide acceptable estimates of the sap flow measurements compared to the commercial sensors.

  5. 46 CFR 164.019-13 - Production quality control requirements.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Production quality control requirements. 164.019-13....019-13 Production quality control requirements. (a) General. Each component manufacturer shall establish procedures for maintaining quality control of the materials used in production,...

  6. 21 CFR 640.56 - Quality control test for potency.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 7 2010-04-01 2010-04-01 false Quality control test for potency. 640.56 Section...) BIOLOGICS ADDITIONAL STANDARDS FOR HUMAN BLOOD AND BLOOD PRODUCTS Cryoprecipitate § 640.56 Quality control test for potency. (a) Quality control tests for potency of antihemophilic factor shall be...

  7. 7 CFR 275.21 - Quality control review reports.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 4 2010-01-01 2010-01-01 false Quality control review reports. 275.21 Section 275.21... Reporting on Program Performance § 275.21 Quality control review reports. (a) General. Each State agency shall submit reports on the performance of quality control reviews in accordance with the...

  8. 7 CFR 58.523 - Laboratory and quality control tests.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Laboratory and quality control tests. 58.523 Section... Service 1 Operations and Operating Procedures § 58.523 Laboratory and quality control tests. (a) Quality control tests shall be made on samples as often as necessary to determine the shelf-life and stability...

  9. 14 CFR 145.211 - Quality control system.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Quality control system. 145.211 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.211 Quality control system. (a) A certificated repair station must establish and maintain a quality control system acceptable...

  10. 21 CFR 864.8625 - Hematology quality control mixture.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Hematology quality control mixture. 864.8625 Section 864.8625 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... quality control mixture. (a) Identification. A hematology quality control mixture is a device used...

  11. 18 CFR 12.40 - Quality control programs.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Quality control... PROJECT WORKS Other Responsibilities of Applicant or Licensee § 12.40 Quality control programs. (a... meeting any requirements or standards set by the Regional Engineer. If a quality control program...

  12. Quality control of cemented waste forms

    Energy Technology Data Exchange (ETDEWEB)

    Slate, L.J.

    1994-12-31

    To insure that cemented radwaste remains immobilized after disposal, certain standards have been set in Europe by the Commission of the European Communities. One such standard is compressive strength. If the compressive strength can be predicted during the early curing stages, time and money can be saved and the quality of the final waste form guaranteed. It was determined that the 7- and 28-day compressive strength from radwaste cementation can be predicted during the mixing and early curing stages by at least three methods. The three that were studied were maturity, rheology, and impedance. Maturity is a temperature-to-time measurement, rheology is a shear stress-to-shear rate measurement, and impedance is the opposition offered to the flow of alternating current. These three methods were employed on five different cemented radwaste concentrations with three different water-to-cement ratios; thus, a total of 15 different mix designs were considered. The results showed that the impedance was the easiest to employ for an on-line process. The results of the impedance method showed a very good relationship between impedance and water-to-cement ratio; therefore, an accurate prediction of compressive strength of cemented radwaste can be drawn from this method. The results of the theology method were very good. The method showed that concrete conforms to the Bingham plastic rheologic model, and the theology method can be used to predict the compressive strength of cemented radwaste, but may be too cumbersome. The results of the maturity method were shown to be limited in accuracy for determining compressive strength.

  13. Managing Air Quality - Control Strategies to Achieve Air Pollution Reduction

    Science.gov (United States)

    Considerations in designing an effective control strategy related to air quality, controlling pollution sources, need for regional or national controls, steps to developing a control strategy, and additional EPA resources.

  14. Development of quality-by-design analytical methods.

    Science.gov (United States)

    Vogt, Frederick G; Kord, Alireza S

    2011-03-01

    Quality-by-design (QbD) is a systematic approach to drug development, which begins with predefined objectives, and uses science and risk management approaches to gain product and process understanding and ultimately process control. The concept of QbD can be extended to analytical methods. QbD mandates the definition of a goal for the method, and emphasizes thorough evaluation and scouting of alternative methods in a systematic way to obtain optimal method performance. Candidate methods are then carefully assessed in a structured manner for risks, and are challenged to determine if robustness and ruggedness criteria are satisfied. As a result of these studies, the method performance can be understood and improved if necessary, and a control strategy can be defined to manage risk and ensure the method performs as desired when validated and deployed. In this review, the current state of analytical QbD in the industry is detailed with examples of the application of analytical QbD principles to a range of analytical methods, including high-performance liquid chromatography, Karl Fischer titration for moisture content, vibrational spectroscopy for chemical identification, quantitative color measurement, and trace analysis for genotoxic impurities.

  15. SPC without Control Limits and Normality Assumption: A New Method

    Science.gov (United States)

    Vazquez-Lopez, J. A.; Lopez-Juarez, I.

    Control Charts (CC) are important Statistic Process Control (SPC) tools developed in the 20's to control and improve the quality of industrial production. The use of CC requires visual inspection and human judgement to diagnoses the process quality properly. CC assume normal distribution in the observed variables to establish the control limits. However, this is a requirement difficult to meet in practice since skewness distributions are commonly observed. In this research, a novel method that neither requires control limits nor data normality is presented. The core of the method is based on the FuzzyARTMAP (FAM) Artificial Neural Network (ANN) that learns special and non-special patterns of variation and whose internal parameters are determined through experimental design to increase its efficiency. The proposed method was implemented successfully in a manufacturing process determining the statistical control state that validate our method.

  16. External quality control for embryology laboratories.

    Science.gov (United States)

    Castilla, Jose Antonio; Ruiz de Assín, Rafael; Gonzalvo, Maria Carmen; Clavero, Ana; Ramírez, Juan Pablo; Vergara, Francisco; Martínez, Luis

    2010-01-01

    Participation in external quality control (EQC) programmes is recommended by various scientific societies. Results from an EQC programme for embryology laboratories are presented. This 5-year programme consisted of the annual delivery of (i) materials to test toxicity and (ii) a DVD/CD-ROM with images of zygotes and embryos on days 2 and 3, on the basis of which the participants were asked to judge the embryo quality and to take a clinical decision. A high degree of agreement was considered achieved when over 75% of the laboratories produced similar classifications. With respect to the materials analysed, the specificity was 68% and the sensitivity was 83%. Concerning embryo classification, the proportion of embryos on which a high degree of agreement was achieved increased during this period from 35% to 55%. No improvement was observed in the degree of agreement on the clinical decision to be taken. Day-3 embryos produced a higher degree of agreement (58%) than did day-2 embryos (32%) (Pembryology laboratories.

  17. 基于改进六西格玛的产品质量控制方法及其应用研究%The application research of product quality control method based on improved six sigma

    Institute of Scientific and Technical Information of China (English)

    李巧玲

    2014-01-01

    提出基于改进的六西格玛方法并作为一种统计工具应用在产品质量改进中,六西格玛的效果在很大程度上取决于对关键工序的定义-测量-分析-改进-控制。对DH电子有限公司半导体制冷器制造工序中的喷镍工序做了当前工序能力分析,发现不足四西格玛水平,然后通过改进的六西格玛方法对该工序的质量水平进行分析并改善,以确保产品的质量合格率。%Presents an application of six sigma as a statistical tool in quality improvement of product .The effect of six sigma large-ly depends on the key processes ’ define-measure-analyze-improve-control.Take the semiconductor refrigeration manufacturing ’ s nickel spray process of the DH electronics company to make process capability analysis ,found that less than four sigma level ,and then use the improved six sigma method to analyze and improve ,to ensure the quality pass rate of the product .

  18. Calibration of Difference Value for the Method of Quality Control to the Sample Being Tailed Inspection%对样本接力跟踪检测质量控制法的差值校正

    Institute of Scientific and Technical Information of China (English)

    魏志武

    2012-01-01

    目的 在“样本接力跟踪检测质量控制法的初步应用”一文方法的基础上,针对在实际应用中可能出现的WBC计数“集中值质控样本(Z样本)”“集中度”不可控的情况,创建“差值校正”方案,以使该法能在更自然宽限的范围择选“Z样本”,使“累积差值(Si)”更准确灵敏地跟踪于“0”偏差.方法 对“接力法”原理及检测原理、偏差本质作进一步延伸分析解读,创建差值校正公式,即:校正差值(当批次Z样本)+当批次Z样本差值+(首批次Z样本首测值一当批次Z样本首测值)×当批次Z样本偏差%;以校正差值来计算Si.结果 接力法系列Z样本原始差值经校正后,均相当于在首批次Z样本含量值水平下产生的“差值”,即时消除了Z样本含量值“集中度”低时对Si可信度及灵敏度的影响.结论 差值校正公式具有合理性,可解决因系列Z样本值的不统一性而引入的“差值干扰”;差值校正后可提高Z样本同时开展多项目质控的适用性.%Objective On method from the basis of "initial application of quality control method for the sample tailed inspection" aimed at the incontrollable situation of "collection degree" for "collection value quality controlled sample (Z sample)" during the period of counting WBC which maybe appear in the actual application, set up a plan "calibration of difference value" to make the method could had a nature wider selection scope in"Z sample" for the purpose of "cumulation of difference value( Si)"could tail more nicety and sensitive to the"O"difference. Methods By more extension analysis to the method theory, test principle and deviation reason, the calibration formula could be set up. Namely,difference value of calibration (Z sample of actual bench )= actual bench difference value of Z sample+(the first value of the first Z sample-first value of actual bench Z sample) X difference value of actual bench Z sample%, Si was

  19. Facing a Problem of Electrical Energy Quality in Ship Networks-measurements, Estimation, Control

    Institute of Scientific and Technical Information of China (English)

    Tomasz Tarasiuk; Janusz Mindykowski; Xiaoyan Xu

    2003-01-01

    In this paper, electrical energy quality and its indices in ship electric networks are introduced, especially the meaning of electrical energy quality terms in voltage and active and reactive power distribution indices. Then methods of measurement of marine electrical energy indices are introduced in details and a microprocessor measurement-diagnosis system with the function of measurement and control is designed. Afterwards, estimation and control of electrical power quality of marine electrical power networks are introduced. And finally, according to the existing method of measurement and control of electrical power quality in ship power networks, the improvement of relative method is proposed.

  20. IMPROVEMENT OF QUALITY IN PRODUCTION PROCESS BY APPLYING KAIKAKU METHOD

    Directory of Open Access Journals (Sweden)

    Milan Radenkovic

    2013-12-01

    Full Text Available In this paper, Kaikaku method is presented. The essence of this method is introduction, principles and ways of implementation in the real systems. The main point how Kaikaku method influences on quality. It is presented on the practical example (furniture industry, one way how to implement Kaikaku method and how influence on quality improvement of production process.

  1. Theoretical and methodical support of calculating expenses for quality

    OpenAIRE

    Пархоменко, Валерій Миколайович

    2015-01-01

    A hybrid models of calculating expenses for quality on the full life cycle in combination with types of expenses on purpose and model of goods costing considering expenses for quality by standard-functional method have been developed.

  2. Surface water quality assessment by environmetric methods.

    Science.gov (United States)

    Boyacioglu, Hülya; Boyacioglu, Hayal

    2007-08-01

    This environmetric study deals with the interpretation of river water monitoring data from the basin of the Buyuk Menderes River and its tributaries in Turkey. Eleven variables were measured to estimate water quality at 17 sampling sites. Factor analysis was applied to explain the correlations between the observations in terms of underlying factors. Results revealed that, water quality was strongly affected from agricultural uses. Cluster analysis was used to classify stations with similar properties and results distinguished three groups of stations. Water quality at downstream of the river was quite different from the other part. It is recommended to involve the environmetric data treatment as a substantial procedure in assessment of water quality data.

  3. A Total Quality-Control Plan with Right-Sized Statistical Quality-Control.

    Science.gov (United States)

    Westgard, James O

    2017-03-01

    A new Clinical Laboratory Improvement Amendments option for risk-based quality-control (QC) plans became effective in January, 2016. Called an Individualized QC Plan, this option requires the laboratory to perform a risk assessment, develop a QC plan, and implement a QC program to monitor ongoing performance of the QC plan. Difficulties in performing a risk assessment may limit validity of an Individualized QC Plan. A better alternative is to develop a Total QC Plan including a right-sized statistical QC procedure to detect medically important errors. Westgard Sigma Rules provides a simple way to select the right control rules and the right number of control measurements.

  4. The consistency approach for the quality control of vaccines.

    Science.gov (United States)

    Hendriksen, Coenraad; Arciniega, Juan L; Bruckner, Lukas; Chevalier, Michel; Coppens, Emmanuelle; Descamps, Johan; Duchêne, Michel; Dusek, David Michael; Halder, Marlies; Kreeftenberg, Hans; Maes, Alexandrine; Redhead, Keith; Ravetkar, Satish D; Spieser, Jean-Marc; Swam, Hanny

    2008-01-01

    Current lot release testing of conventional vaccines emphasizes quality control of the final product and is characterized by its extensive use of laboratory animals. This report, which is based on the outcome of an ECVAM (European Centre for Validation of Alternative Methods, Institute for Health and Consumer Protection, European Commission Joint Research Centre, Ispra, Italy) workshop, discusses the concept of consistency testing as an alternative approach for lot release testing. The consistency approach for the routine release of vaccines is based upon the principle that the quality of vaccines is a consequence of a quality system and of consistent production of lots with similar characteristics to those lots that have been shown to be safe and effective in humans or the target species. The report indicates why and under which circumstances this approach can be applied, the role of the different stakeholders, and the need for international harmonization. It also gives recommendations for its implementation.

  5. Chapter 5: Quality assurance/quality control in stormwater sampling

    Science.gov (United States)

    Sampling the quality of stormwater presents unique challenges because stormwater flow is relatively short-lived with drastic variability. Furthermore, storm events often occur with little advance warning, outside conventional work hours, and under adverse weather conditions. Therefore, most stormwat...

  6. Model based control charts in stage 1 quality control

    NARCIS (Netherlands)

    A.J. Koning (Alex)

    1999-01-01

    textabstractIn this paper a general method of constructing control charts for preliminary analysis of individual observations is presented, which is based on recursive score residuals. A simulation study shows that certain implementations of these charts are highly effective in detecting assignable

  7. Analysis and Comparison of Objective Methods for Image Quality Assessment

    Directory of Open Access Journals (Sweden)

    P. S. Babkin

    2014-01-01

    Full Text Available The purpose of this work is research and modification of the reference objective methods for image quality assessment. The ultimate goal is to obtain a modification of formal assessments that more closely corresponds to the subjective expert estimates (MOS.In considering the formal reference objective methods for image quality assessment we used the results of other authors, which offer results and comparative analyzes of the most effective algorithms. Based on these investigations we have chosen two of the most successful algorithm for which was made a further analysis in the MATLAB 7.8 R 2009 a (PQS and MSSSIM. The publication focuses on the features of the algorithms, which have great importance in practical implementation, but are insufficiently covered in the publications by other authors.In the implemented modification of the algorithm PQS boundary detector Kirsch was replaced by the boundary detector Canny. Further experiments were carried out according to the method of the ITU-R VT.500-13 (01/2012 using monochrome images treated with different types of filters (should be emphasized that an objective assessment of image quality PQS is applicable only to monochrome images. Images were obtained with a thermal imaging surveillance system. The experimental results proved the effectiveness of this modification.In the specialized literature in the field of formal to evaluation methods pictures, this type of modification was not mentioned.The method described in the publication can be applied to various practical implementations of digital image processing.Advisability and effectiveness of using the modified method of PQS to assess the structural differences between the images are shown in the article and this will be used in solving the problems of identification and automatic control.

  8. 统一电能质量控制器电压电流综合检测方法的研究%Research on Voltage and Current Detection Method of Unified Power Quality Controller

    Institute of Scientific and Technical Information of China (English)

    唐春东

    2011-01-01

    With the development of power electronics, nonlinear load is widely used in power system, which brings about serious pollution and unsafe operation for power grid. The UPQC (Unified Power Quality Controller) contains volrage compensator, current compensator and energy storage device. On analyzing the APF detecting method, the detection method based on symmetric component method and generalized instantaneous power theory is deduced. In detection method, the voltage compensation detection result can be applied in the current compensation detectio. It ensures that reference current phase is accordance with positive fundamental voltages phase. Simulation results verify the correctness and feasibility of the detection method.%利用统一电能质量控制器解决了多重电压、电流质量问题的特性及需求.在研究有源滤波器检测方法的基础上,从理论上推导出一种基于对称分量法和瞬时功率理论的统一电能质量控制器电压电流检测方法.该检测方法将电压补偿量检测的结果直接应用与电流补偿量的检测中,保证了参考电流与基波正序电压相位的一致,具有较好的补偿效果.经过建模仿真研究,理论分析与仿真结果验证该方法的有效性和可行性.

  9. Rapid and quantitative quality control of microarrays using cationic nanoparticles.

    Science.gov (United States)

    Sun, Ye; Fan, Wenhua; McCann, Michael P; Golovlev, Val

    2009-02-15

    The fabrication quality of microarrays significantly influences the accuracy and reproducibility of microarray experiments. In this report, we present a simple and fast quality control (QC) method for spotted oligonucleotide and cDNA microarrays. It employs a nonspecific electrostatic interaction of colloidal gold nanoparticles with the chemical groups of DNA molecules and other biomolecules immobilized on the microarray surface that bear positive or negative charges. An inexpensive flatbed scanner is used to visualize and quantify the binding of cationic gold particles to the anionic DNA probes on the microarray surface. An image analysis software was designed to assess the various parameters of the array spots including spot intensity, shape and array homogeneity, calculate the overall array quality score, and save the detailed array quality report in an Excel file. The gold staining technique is fast and sensitive. It can be completed in 10 min and detect less than 1% of the probe amount commonly recommended for microarrays. Compared to the current microarray QC method that utilizes the hybridization of probes with short random sequence oligonucleotides labeled with fluorophore, our gold staining method requires less time for the analysis, reduces the reagent cost, and eliminates the need for the expensive laser scanner.

  10. REAL TIME QUALITY CONTROL OF THE HEATSET OFFSET PRINTING PROCESS

    Directory of Open Access Journals (Sweden)

    Răzvan-George RĂCHERU

    2016-05-01

    Full Text Available Offset lithography is one of the most common ways of creating printed materials. Compared to other printing methods, offset printing is best suited for economically producing large volumes of high quality prints in a manner that requires little maintenance. Because of the high speed and the high volume of the printing press, we have to rely on automation for press control and not just to the printer’s eye. When printing an image that has more than one color, it is necessary to print each color separately and ensure each color overlaps the others precisely. If this is not done, the finished image will look fuzzy, blurred or "out of register". To help line the colors up correctly, a system of registration is necessary. Therefore, the use of an automated real time quality control system will result in a more consistent color for the customer and less waste for the printer.

  11. Quality control for quantitative PCR based on amplification compatibility test.

    Science.gov (United States)

    Tichopad, Ales; Bar, Tzachi; Pecen, Ladislav; Kitchen, Robert R; Kubista, Mikael; Pfaffl, Michael W

    2010-04-01

    Quantitative qPCR is a routinely used method for the accurate quantification of nucleic acids. Yet it may generate erroneous results if the amplification process is obscured by inhibition or generation of aberrant side-products such as primer dimers. Several methods have been established to control for pre-processing performance that rely on the introduction of a co-amplified reference sequence, however there is currently no method to allow for reliable control of the amplification process without directly modifying the sample mix. Herein we present a statistical approach based on multivariate analysis of the amplification response data generated in real-time. The amplification trajectory in its most resolved and dynamic phase is fitted with a suitable model. Two parameters of this model, related to amplification efficiency, are then used for calculation of the Z-score statistics. Each studied sample is compared to a predefined reference set of reactions, typically calibration reactions. A probabilistic decision for each individual Z-score is then used to identify the majority of inhibited reactions in our experiments. We compare this approach to univariate methods using only the sample specific amplification efficiency as reporter of the compatibility. We demonstrate improved identification performance using the multivariate approach compared to the univariate approach. Finally we stress that the performance of the amplification compatibility test as a quality control procedure depends on the quality of the reference set.

  12. 14 CFR 21.147 - Changes in quality control system.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Changes in quality control system. 21.147 Section 21.147 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION... quality control system. After the issue of a production certificate, each change to the quality...

  13. Possibilities of obtaining and controlling high-quality pressure castings

    Directory of Open Access Journals (Sweden)

    S. Pietrowski

    2011-07-01

    Full Text Available The paper presents the influence of the type of furnace charging melting, refining and modification silumins 226 and 231 on the porosity and microstructure of castings. It was shown that in order to reduce or eliminate the porosity of the castings is necessary to the refining ECOSAL-AL113 of liquid silumin both in the melting furnace, and in the ladle and an additional nitrogen, in the heat furnace modified and refining with nitrogen. To control the effects of refining and modifying the TDA method was used. It was found that based on crystal- lization curve can be qualitatively assess the gas porosity of the castings. In order to control and quality control silumins author developed a computer program using the method of TDA, which sets out: Rm, A5, HB and casting porosity P and the concentration of hydrogen in them. The program also informs the technological procedures to be performed for liquid silumin improper preparation.

  14. Oil Products Quality Improvement by Adsorption Method

    Directory of Open Access Journals (Sweden)

    Kulash K. Syrmanova

    2017-02-01

    Full Text Available Petroleum takes the leading place in fuel and energy sector. It is a basis of fuel and energy balance of advanced countries economics. Light oil proven reserves reducing is a general trend of modern oil industry development. Almost the entire increase in reserves is due to viscous heavy sour oil [1-2]. Nowadays quality of the most important oil products is a crucial problem in refinery industry. The problem of oil products quality is connected with their using and operation in engines and machines. Requirements increasing to stability and effective technics maintenance leads to oil products running abilities significant hardening. In order to protect the environment, the task to obtain oil products with improved environmental properties was assigned. Properties of the oil determine the direction and condition of its processing and directly affect the quality of the oil products [3-4].

  15. Study on the Application of Quality Control Method and Installation Technology of Electrical Installation Construction%电气安装施工的质控思路及安装工艺的应用研究

    Institute of Scientific and Technical Information of China (English)

    陈治江

    2015-01-01

    This paper briefly analyzes the influence factors of electrical installation engineering construction quality, and on this basis, the electrical installation engineering quality control ideas and installation process are discussed, in order to provide reference for electrical installation engineering construction quality improvement.%简要分析了电气安装工程施工质量的影响因素,并在此基础上,对电气安装工程的质控思路和安装工艺进行了论述,以期为电气安装工程施工质量的提升提供借鉴.

  16. Quality Index Method - An objective tool for determination of sensory quality

    DEFF Research Database (Denmark)

    Hyldig, Grethe; Green-Petersen, Ditte

    2004-01-01

    seen as a subjective assessment of quality. However, sensory methods can be turned into an objective tool. European fisheries research institutes have developed such a tool, by which sensory assessment is performed in a systematic way with an objective quality assessment method called the Quality Index...

  17. Control of quality in spectrometry gamma of low level

    CERN Document Server

    Salazar, A

    1997-01-01

    Low level gamma spectrometry is a very precise technique to measure the concentration of nuclides present in different samples in Bq kg sup - sup 1. The quality control of the procedure and method used can be carried out by intercomparison exercises with world recognized institutions. During the last three years the Nuclear Physics Laboratory Of The University of Costa Rica (LAFNA) has been participating in the international quality assessment program (QAP) carried out by the Environmental Measurements Laboratory (EML), department of Energy, USA. The results show a very good agreement with the rest of the participant laboratories. This provides a very objective evaluation of the high precision of the methods used by LAFNA in low level spectroscopy measurements. (Author)

  18. Cumulative sum quality control for calibrated breast density measurements

    Energy Technology Data Exchange (ETDEWEB)

    Heine, John J.; Cao Ke; Beam, Craig [Cancer Prevention and Control Division, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, Florida 33612 (United States); Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, 1603 W. Taylor St., Chicago, Illinois 60612 (United States)

    2009-12-15

    Purpose: Breast density is a significant breast cancer risk factor. Although various methods are used to estimate breast density, there is no standard measurement for this important factor. The authors are developing a breast density standardization method for use in full field digital mammography (FFDM). The approach calibrates for interpatient acquisition technique differences. The calibration produces a normalized breast density pixel value scale. The method relies on first generating a baseline (BL) calibration dataset, which required extensive phantom imaging. Standardizing prospective mammograms with calibration data generated in the past could introduce unanticipated error in the standardized output if the calibration dataset is no longer valid. Methods: Sample points from the BL calibration dataset were imaged approximately biweekly over an extended timeframe. These serial samples were used to evaluate the BL dataset reproducibility and quantify the serial calibration accuracy. The cumulative sum (Cusum) quality control method was used to evaluate the serial sampling. Results: There is considerable drift in the serial sample points from the BL calibration dataset that is x-ray beam dependent. Systematic deviation from the BL dataset caused significant calibration errors. This system drift was not captured with routine system quality control measures. Cusum analysis indicated that the drift is a sign of system wear and eventual x-ray tube failure. Conclusions: The BL calibration dataset must be monitored and periodically updated, when necessary, to account for sustained system variations to maintain the calibration accuracy.

  19. The quality control theory of aging

    Directory of Open Access Journals (Sweden)

    Warren Ladiges

    2014-05-01

    Full Text Available The quality control (QC theory of aging is based on the concept that aging is the result of a reduction in QC of cellular systems designed to maintain lifelong homeostasis. Four QC systems associated with aging are 1 inadequate protein processing in a distressed endoplasmic reticulum (ER; 2 histone deacetylase (HDAC processing of genomic histones and gene silencing; 3 suppressed AMPK nutrient sensing with inefficient energy utilization and excessive fat accumulation; and 4 beta-adrenergic receptor (BAR signaling and environmental and emotional stress. Reprogramming these systems to maintain efficiency and prevent aging would be a rational strategy for increased lifespan and improved health. The QC theory can be tested with a pharmacological approach using three well-known and safe, FDA-approved drugs: 1 phenyl butyric acid, a chemical chaperone that enhances ER function and is also an HDAC inhibitor, 2 metformin, which activates AMPK and is used to treat type 2 diabetes, and 3 propranolol, a beta blocker which inhibits BAR signaling and is used to treat hypertension and anxiety. A critical aspect of the QC theory, then, is that aging is associated with multiple cellular systems that can be targeted with drug combinations more effectively than with single drugs. But more importantly, these drug combinations will effectively prevent, delay, or reverse chronic diseases of aging that impose such a tremendous health burden on our society.

  20. QUALITY CONTROL OF SOME TRADITIONAL MEAT PRODUCTS

    Directory of Open Access Journals (Sweden)

    S. DOBRINAS

    2014-03-01

    Full Text Available In this paper, we present the characterization of six traditional meat products: smoked file, smoked bacon, pork sausages, sausage prepared from swine’s entrails, pork pastrami, sheep sausages. Organoleptic tests (the aspect and shape, the aspect of freshly cut in the section, smell, taste and consistency, physico-chemical and microbiological determinations (NTG, Salmonella, Listeria monocytogenes and Escherichia coli were performed. These analyzes are a part of quality control that must be done in order to obtain a certificate from the Ministry of Agriculture for a traditional product. After identification of H2S and starch and according to fat oxidation degree it was concluded that analyzed samples didn’t contain counterfeiters and all parameters analyzed are within the maximum limits allowed by law. Considering all the procedures for manufacturing, characteristics of raw and auxiliary materials, organoleptic properties of final products analyzed in this study, it can be concluded that analyzed meat specialties meet the requirements of Ministry Order no. 690/28.09.2004 for the traditional products certification.

  1. The quality control theory of aging.

    Science.gov (United States)

    Ladiges, Warren

    2014-01-01

    The quality control (QC) theory of aging is based on the concept that aging is the result of a reduction in QC of cellular systems designed to maintain lifelong homeostasis. Four QC systems associated with aging are 1) inadequate protein processing in a distressed endoplasmic reticulum (ER); 2) histone deacetylase (HDAC) processing of genomic histones and gene silencing; 3) suppressed AMPK nutrient sensing with inefficient energy utilization and excessive fat accumulation; and 4) beta-adrenergic receptor (BAR) signaling and environmental and emotional stress. Reprogramming these systems to maintain efficiency and prevent aging would be a rational strategy for increased lifespan and improved health. The QC theory can be tested with a pharmacological approach using three well-known and safe, FDA-approved drugs: 1) phenyl butyric acid, a chemical chaperone that enhances ER function and is also an HDAC inhibitor, 2) metformin, which activates AMPK and is used to treat type 2 diabetes, and 3) propranolol, a beta blocker which inhibits BAR signaling and is used to treat hypertension and anxiety. A critical aspect of the QC theory, then, is that aging is associated with multiple cellular systems that can be targeted with drug combinations more effectively than with single drugs. But more importantly, these drug combinations will effectively prevent, delay, or reverse chronic diseases of aging that impose such a tremendous health burden on our society.

  2. Quality control chart for crushed granite concrete

    Directory of Open Access Journals (Sweden)

    Ewa E. DESMOND

    2016-07-01

    Full Text Available A chart for assessing in-situ grade (strength of concrete, has been developed in this study. Four grades of concrete after the Nigerian General Specification for Roads and bridges (NGSRB-C20, C25, C30 and C35, is studied at different water-cement ratios for medium and high slump range. The concrete mixes are made from crushed granite rock as coarse aggregate with river sand as fine aggregate. Compression test on specimens are conducted at curing age of 1, 3, 7, 14, 21, 28 and 56 days. Results on concrete workability from slump values, and water-cement ratios revealed that specimens with lower water-cement ratio were less workable but had higher strength, compared to mixes with higher water cement ratio. A simple algorithm using nonlinear regression analysis performed on each experimental data set produced Strength-Age (S-A curves which were used to establish a quality control chart. The accuracy of these curves were evaluated by computing average absolute error (AAS, the error of estimate (EoE and the average absolute error of estimate (Abs EoE for each concrete mix. These were done based on the actual average experimental strengths to measure how close the predicted values are to the experimental data set. The absolute average error of estimate (Abs. EoE recorded was less than ±10% tolerance zone for concrete works.

  3. MITOCHONDRIA QUALITY CONTROL AND MUSCLE MASS MAINTENANCE

    Directory of Open Access Journals (Sweden)

    Vanina eRomanello

    2016-01-01

    Full Text Available Loss of muscle mass and force occurs in many diseases such as disuse/inactivity, diabetes, cancer, renal and cardiac failure and in aging-sarcopenia. In these catabolic conditions the mitochondrial content, morphology and function are greatly affected. The changes of mitochondrial network influence the production of reactive oxygen species (ROS that play an important role in muscle function. Moreover, dysfunctional mitochondria trigger catabolic signaling pathways which feed-forward to the nucleus to promote the activation of muscle atrophy. Exercise, on the other hand, improves mitochondrial function by activating mitochondrial biogenesis and mitophagy, possibly playing an important part in the beneficial effects of physical activity in several diseases. Optimised mitochondrial function is strictly maintained by the coordinated activation of different mitochondrial quality control pathways. In this review we outline the current knowledge linking mitochondria-dependent signaling pathways to muscle homeostasis in aging and disease and the resulting implications for the development of novel therapeutic approaches to prevent muscle loss.

  4. Managing Quality in Higher Education Systems via Minimal Quality Requirements: Signaling and Control.

    Science.gov (United States)

    Mizrahi, Shlomo; Mehrez, Abraham

    2002-01-01

    Discusses two versions of a signaling game to set minimal quality requirements for higher education applicants in Israel: one assumes low sensitivity to quality, the other high sensitivity. Concludes that indirect government influence on quality variations in applicant pool is more effective in controlling institutional quality then direct…

  5. Analytical approaches to quality assurance and quality control in rangeland monitoring data

    Science.gov (United States)

    Producing quality data to support land management decisions is the goal of every rangeland monitoring program. However, the results of quality assurance (QA) and quality control (QC) efforts to improve data quality are rarely reported. The purpose of QA and QC is to prevent and describe non-sampling...

  6. Quality assurance standards for purchasing and inventory control.

    Science.gov (United States)

    Soares, D P

    1985-03-01

    A process is described for quality assurance in pharmaceutical purchasing and inventory control. A quality assurance program should ensure that quality drugs are purchased at the lowest price, drug products are available when needed, the system is managed efficiently, internal controls are provided, drug products are stored under appropriate conditions, and laws, regulations, accreditation standards, and procedures are followed. To meet these objectives, product quality, vendor performance, the department's system of internal controls, purchasing data, and storage conditions should be monitored. A checklist for evaluating purchasing and inventory practices and a sample audit form listing quality assurance criteria, standards, procedures, and recommended actions are provided. A quality assurance program for pharmaceutical purchasing and inventory control should define institution-specific criteria and standards and use these standards for continual evaluation of all aspects of the purchasing and inventory control system. Documentation of quality assurance activities should be provided for use by the purchasing department, hospital administration, and regulatory bodies.

  7. Analyzing of coffee quality with different methods

    Directory of Open Access Journals (Sweden)

    Rajković Miloš B.

    2004-01-01

    Full Text Available The results obtained by the analysis of the samples of coffee mostly consumed on our market showed that the coffee quality corresponds to the values as given in the Law of Health Food. It was not found that any of the parameters which determine food quality exceeded permitted values. Content of heavy metals and aflatoxines is below permitted values. The least content of caffeine was determined in a coffee sample roasted in the private roaster’s shop, and only in it the presence of coffee surrogates/substitutes was not proved. The obtained results of the coffee analysis showed that the coffees of most popular producers are very equal, and results of caffeine analysis are even more equal. This indicates the most probable fact that coffee is of the same origin, and that later, on during production, a different mixture was made, which affects the final product and gives aroma and taste to the liquid.

  8. Eddy current quality control of soldered current-carrying busbar splices of superconducting magnets

    CERN Document Server

    Kogan, L; Savary, F; Principe, R; Datskov, V; Rozenfel'd, E; Khudjakov, B

    2015-01-01

    The eddy current technique associated with a U-shaped transducer is studied for the quality control of soldered joints between superconducting busbars ('splices'). Two other quality control techniques, based on X-rays and direct measurement of the electrical resistance, are also studied for comparison. A comparative analysis of the advantages and disadvantages of these three methods in relation to the quality control of soldered superconducting busbar cables enclosed in copper shells is used for benchmarking. The results of inspections with the U-shaped eddy current transducer carried out on several sample joints presenting different types of soldering defects show the potential of this type of nondestructive (ND) quality control technique.

  9. Automated quality control in a file-based broadcasting workflow

    Science.gov (United States)

    Zhang, Lina

    2014-04-01

    Benefit from the development of information and internet technologies, television broadcasting is transforming from inefficient tape-based production and distribution to integrated file-based workflows. However, no matter how many changes have took place, successful broadcasting still depends on the ability to deliver a consistent high quality signal to the audiences. After the transition from tape to file, traditional methods of manual quality control (QC) become inadequate, subjective, and inefficient. Based on China Central Television's full file-based workflow in the new site, this paper introduces an automated quality control test system for accurate detection of hidden troubles in media contents. It discusses the system framework and workflow control when the automated QC is added. It puts forward a QC criterion and brings forth a QC software followed this criterion. It also does some experiments on QC speed by adopting parallel processing and distributed computing. The performance of the test system shows that the adoption of automated QC can make the production effective and efficient, and help the station to achieve a competitive advantage in the media market.

  10. Quality control with R an ISO standards approach

    CERN Document Server

    Cano, Emilio L; Prieto Corcoba, Mariano

    2015-01-01

    Presenting a practitioner's guide to capabilities and best practices of quality control systems using the R programming language, this volume emphasizes accessibility and ease-of-use through detailed explanations of R code as well as standard statistical methodologies. In the interest of reaching the widest possible audience of quality-control professionals and statisticians, examples throughout are structured to simplify complex equations and data structures, and to demonstrate their applications to quality control processes, such as ISO standards. The volume balances its treatment of key aspects of quality control, statistics, and programming in R, making the text accessible to beginners and expert quality control professionals alike. Several appendices serve as useful references for ISO standards and common tasks performed while applying quality control with R.

  11. 42 CFR 84.256 - Quality control requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Quality control requirements. 84.256 Section 84.256... § 84.256 Quality control requirements. (a) In addition to the construction and performance requirements specified in §§ 84.251, 84.252, 84.253, 84.254, and 84.255, the quality control requirements in...

  12. The consistency approach for quality control of vaccines - a strategy to improve quality control and implement 3Rs.

    Science.gov (United States)

    De Mattia, Fabrizio; Chapsal, Jean-Michel; Descamps, Johan; Halder, Marlies; Jarrett, Nicholas; Kross, Imke; Mortiaux, Frederic; Ponsar, Cecile; Redhead, Keith; McKelvie, Jo; Hendriksen, Coenraad

    2011-01-01

    Current batch release testing of established vaccines emphasizes quality control of the final product and is often characterized by extensive use of animals. This report summarises the discussions of a joint ECVAM/EPAA workshop on the applicability of the consistency approach for routine release of human and veterinary vaccines and its potential to reduce animal use. The consistency approach is based upon thorough characterization of the vaccine during development and the principle that the quality of subsequent batches is the consequence of the strict application of a quality system and of a consistent production of batches. The concept of consistency of production is state-of-the-art for new-generation vaccines, where batch release is mainly based on non-animal methods. There is now the opportunity to introduce the approach into established vaccine production, where it has the potential to replace in vivo tests with non-animal tests designed to demonstrate batch quality while maintaining the highest quality standards. The report indicates how this approach may be further developed for application to established human and veterinary vaccines and emphasizes the continuing need for co-ordination and harmonization. It also gives recommendations for work to be undertaken in order to encourage acceptance and implementation of the consistency approach.

  13. QUALITY CONTROL FOR EFFECTIVE BASIC EDUCATION IN

    African Journals Online (AJOL)

    Ghana 's educational system yet the system of monitoring schools is governed by an “evolving” policy. ... that schools are well supervised and that the quality of what ... quality comes from having the best equipment, the best .... performance in the classroom and their career ... the number of teachers employed and the size of.

  14. Endoplasmic reticulum quality control and apoptosis.

    Science.gov (United States)

    Groenendyk, Jody; Michalak, Marek

    2005-01-01

    The ER is one of the most important folding compartments within the cell, as well as an intracellular Ca(2+) storage organelle and it contains a number of Ca(2+) regulated molecular chaperones responsible for the proper folding of glycosylated as well as non-glycosylated proteins. The luminal environment of the ER contains Ca(2+) which is involved in regulating chaperones such as calnexin and calreticulin, as well as apoptotic proteins caspase-12 and Bap31, which may play an important role in determining cellular sensitivity to ER stress and apoptosis. The ER quality control system consists of several molecular chaperones, including calnexin, that assist in properly folding proteins and transporting them through the ER as well as sensing misfolded proteins, attempting to refold them and if this is not possible, targeting them for degradation. Accumulation of misfolded protein in the ER leads to activation of genes responsible for the expression of ER chaperones. The UPR mechanism involves transcriptional activation of chaperones by the membrane-localized transcription factor ATF6, in conjunction with the ER membrane kinase IRE1, as well as translational repression of protein synthesis by another ER membrane kinase PERK. When accumulation of misfolded protein becomes toxic, apoptosis is triggered, potentially with IRE1 involved in signaling via caspase-12. Both the extrinsic and intrinsic apoptotic pathways appear to culminate in the activation of caspases and this results in the recruitment of mitochondria in an essential amplifying manner. Bap31 may direct pro-apoptotic crosstalk between the ER and the mitochondria via Ca(2+) in conjunction with caspase-12 and calnexin. Accordingly, ER stress and the resultant Ca(2+) release must be very carefully regulated because of their effects in virtually all areas of cell function.

  15. Quality control for quantitative geophysical logging

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Kyu; Hwang, Se Ho; Hwang, Hak Soo; Park, In Hwa [Korea Institute of Geology Mining and Materials, Taejon (Korea)

    1998-12-01

    Despite the great availability of geophysical data obtained from boreholes, the interpretation is subject to significant uncertainties. More accurate data with less statistical uncertainties should require an employment of more quantitative techniques in log acquisition and interpretation technique. The long-term objective of this project is the development of techniques in both quality control of log measurement and the quantitative interpretation. In the first year, the goals of the project will include establishing the procedure of log acquisition using various tests, analysing the effect of logging velocity change on the logging data, examining the repeatability and reproducibility, analyzing of filtering effect on the log measurements, and finally the zonation and the correlation of single-and inter-well log data. For the establishment of logging procedure, we have tested the multiple factors affecting the accuracy in depth. The factors are divided into two parts: human and mechanical. These factors include the zero setting of depth, the calculation of offset for the sonde, the stretching effect of cable, and measuring wheel accuracy. We conclude that the error in depth setting results primarily from human factor, and also in part from the stretching of cable. The statistical fluctuation of log measurements increases according to increasing the logging speed for the zone of lower natural gamma. Thus, the problem related with logging speed is a trifling matter in case of the application of resources exploration, the logging speed should run more slowly to reduce the statistical fluctuation of natural gamma with lithologic correlation in mind. The repeatability and reproducibility of logging measurements are tested. The results of repeatability test for the natural gamma sonde are qualitatively acceptable in the reproducibility test, the errors occurs in logging data between two operators and successive trials. We conclude that the errors result from the

  16. Radiation Dosimetry for Quality Control of Food Preservation and Disinfestation

    DEFF Research Database (Denmark)

    McLaughlin, W.L.; Miller, Arne; Uribe, R.M.

    1983-01-01

    In the use of x and gamma rays and scanned electron beams to extend the shelf life of food by delay of sprouting and ripening, killing of microbes, and control of insect population, quality assurance is provided by standardized radiation dosimetry. By strategic placement of calibrated dosimeters...... speed) to meet changes that occur in product and source parameters (e.g. bulk density and radiation spectrum). Routine dosimetry methods and certain corrections of dosimetry data may be selected for the radiations used in typical food processes....

  17. Mathematical models of magnetite desliming for automated quality control systems

    Science.gov (United States)

    Olevska, Yu.; Mishchenko, V.; Olevskyi, V.

    2016-10-01

    The aim of the study is to provide multifactor mathematical models suitable for use in automatic control systems of desliming process. For this purpose we described the motion of a two-phase environment regard to the shape the desliming machine and technological parameters of the enrichment process. We created the method for preparation of dependences of the enrichment process quality from the technological and design parameters. To automate the process we constructed mathematical models to justify intensive technological modes and optimal parameters for design of desliming machine.

  18. Methods for subjective determination of transmission quality

    CERN Document Server

    International Telecommunication Union. Geneva

    2000-01-01

    The main purpose of this List is to indicate all the ITU-T (and CCITT) Recommendations currently in effect at the date of its publication In addition, it includes the CCITT/ITU-T Supplements which contain operational or other practical/implementation a particular Series of Recommendations. At present, more than 2600 recommendations (standards) on some 60,000 pages are in force. Recommendations are non-binding standards agreed by consensus in technical study groups. ITU-T Recommendations are non-binding, however they are generally complied with due to their high quality and because they guarantee the interconnectivity of networks and enable telecommunication services to be provided on a worldwide scale.

  19. W-methods in optimal control

    NARCIS (Netherlands)

    J. Lang; J.G. Verwer (Jan)

    2013-01-01

    htmlabstractThis paper addresses consistency and stability of W-methods up to order three for nonlinear ODE-constrained control problems with possible restrictions on the control. The analysis is based on the transformed adjoint system and the control uniqueness property. These methods can also be

  20. A control method for voltage balancing in modular multilevel converters

    DEFF Research Database (Denmark)

    Deng, Fujin; Chen, Zhe

    2014-01-01

    The modular multilevel converter (MMC) is attractive for medium- or high-power applications because of the advantages of its high modularity, availability, and high power quality. The voltage balancing of the floating capacitors in the cascaded submodules of the MMC is a key issue. In this paper......, a voltage-balancing control method is proposed. This method uses the phase-shifted carrier-based pulsewidth modulation scheme to control high-frequency current components for capacitor voltage balancing in the MMC without measuring the arm currents. Simulations and experimental studies of the MMC were...... conducted, and the results confirm the effectiveness of the proposed capacitor voltage-balancing control method....

  1. New tuning method for PID controller.

    Science.gov (United States)

    Shen, Jing-Chung

    2002-10-01

    In this paper, a tuning method for proportional-integral-derivative (PID) controller and the performance assessment formulas for this method are proposed. This tuning method is based on a genetic algorithm based PID controller design method. For deriving the tuning formula, the genetic algorithm based design method is applied to design PID controllers for a variety of processes. The relationship between the controller parameters and the parameters that characterize the process dynamics are determined and the tuning formula is then derived. Using simulation studies, the rules for assessing the performance of a PID controller tuned by the proposed method are also given. This makes it possible to incorporate the capability to determine if the PID controller is well tuned or not into an autotuner. An autotuner based on this new tuning method and the corresponding performance assessment rules is also established. Simulations and real-time experimental results are given to demonstrate the effectiveness and usefulness of these formulas.

  2. A simple method for the quality control of the isocenter of cone beam CT for Elekta Accelerator system Synery; Un metodo sencillo para el control de calidad del isocentro del sistema Cone Beam CT para un acelerador Elekta Synery

    Energy Technology Data Exchange (ETDEWEB)

    Clemente Gutierrez, F.; Perez Vara, C.; Prieto Villacorta, M.

    2013-07-01

    Techniques of image-guided radiation therapy has been spreading over the past years. Cone-beam tomography systems constitute a particular case. As any team that employs ionizing radiation in the diagnosis or treatment of patients, such a system must be seen within a guarantee program of quality according to the recommendations and regulations. In particular, between geometric proofs referred to in such a program for these systems, must be referred to the verification of the coincidence between the isocentres of the treatment unit and the team's image. This work includes the weekly procedure followed for such verification. (Author)

  3. Employee quality, monitoring environment and internal control

    National Research Council Canada - National Science Library

    Chunli Liu Bin Lin Wei Shu

    2017-01-01

    ... quality.We examine the effect of monitoring on this result and find that the effect is more pronounced for firms with strict monitoring environments, especially when the firms implement the Chinese internal...

  4. AUTOMATION OF THE SYSTEM OF INTERNAL LABORATORY QUALITY CONTROL

    Directory of Open Access Journals (Sweden)

    V. Z. Stetsyuk

    2015-05-01

    Full Text Available Quality control system base d on the principles of standardi zation of all phases of laboratory testing and analysis of internal laboratory quality control and external quality assessment. For the detection accuracy of the results of laboratory tests, carried out internally between the laboratory and laboratory quality control. Under internal laboratory quality control we understand measurement results of each analysis in each anal ytical series rendered directly in the lab every day. The purpose of internal laboratory control - identifying and eliminating unacceptable deviations from standard perfor mance test in the laboratory, i.e. identifying and eliminating harmful analytical errors. The solutions to these problems by implementing automated systems - software that allows you to optimize analytical laboratory research stage of the procedure by automatically creating process control charts was shown.

  5. 10 CFR 26.167 - Quality assurance and quality control.

    Science.gov (United States)

    2010-01-01

    ... acceptable values are obtained for the known calibrators, those values will be used to calculate sample data... performing specific gravity tests: (i) The refractometer must report and display the specific gravity to four... initial and confirmatory specific gravity tests must have a calibrator or control at 1.0000; and (iii) The...

  6. Managing Air Quality - Multi-Pollutant Planning and Control

    Science.gov (United States)

    Describes how planning controls for multiple pollutants at the same time can save money and time and achieve significant benefits, and how control strategies can address both climate change and air quality.

  7. Teaching Quality Control with Chocolate Chip Cookies

    Science.gov (United States)

    Baker, Ardith

    2014-01-01

    Chocolate chip cookies are used to illustrate the importance and effectiveness of control charts in Statistical Process Control. By counting the number of chocolate chips, creating the spreadsheet, calculating the control limits and graphing the control charts, the student becomes actively engaged in the learning process. In addition, examining…

  8. Teaching Quality Control with Chocolate Chip Cookies

    Science.gov (United States)

    Baker, Ardith

    2014-01-01

    Chocolate chip cookies are used to illustrate the importance and effectiveness of control charts in Statistical Process Control. By counting the number of chocolate chips, creating the spreadsheet, calculating the control limits and graphing the control charts, the student becomes actively engaged in the learning process. In addition, examining…

  9. The History of Infant Formula: Quality, Safety, and Standard Methods.

    Science.gov (United States)

    Wargo, Wayne F

    2016-01-01

    Food-related laws and regulations have existed since ancient times. Egyptian scrolls prescribed the labeling needed for certain foods. In ancient Athens, beer and wines were inspected for purity and soundness, and the Romans had a well-organized state food control system to protect consumers from fraud or bad produce. In Europe during the Middle Ages, individual countries passed laws concerning the quality and safety of eggs, sausages, cheese, beer, wine, and bread; some of these laws still exist today. But more modern dietary guidelines and food regulations have their origins in the latter half of the 19th century when the first general food laws were adopted and basic food control systems were implemented to monitor compliance. Around this time, science and food chemistry began to provide the tools to determine "purity" of food based primarily on chemical composition and to determine whether it had been adulterated in any way. Since the key chemical components of mammalian milk were first understood, infant formulas have steadily advanced in complexity as manufacturers attempt to close the compositional gap with human breast milk. To verify these compositional innovations and ensure product quality and safety, infant formula has become one of the most regulated foods in the world. The present paper examines the historical development of nutritional alternatives to breastfeeding, focusing on efforts undertaken to ensure the quality and safety from antiquity to present day. The impact of commercial infant formulas on global regulations is addressed, along with the resulting need for harmonized, fit-for-purpose, voluntary consensus standard methods.

  10. Dependence of Growing High-Quality Gem Diamonds on Growth Rates by Temperature Gradient Method

    Institute of Scientific and Technical Information of China (English)

    ZANG Chuan-Yi; JIA Xiao-Peng; REN Guo-Zhong; WANG Xian-Cheng

    2004-01-01

    @@ Using the temperature gradient method under high pressure and high temperature, we investigate the dependence of growing high-quality gem diamond crystals on the growth rates. It is found that the lower the growth rate of gem diamond crystals, the larger the temperature range of growing high-quality gem diamond crystals, and the easier the control of temperature.

  11. Quality control procedures in MISH-MASH systems

    Science.gov (United States)

    Szentimrey, T.; Bihari, Z.; Lakatos, M.

    2010-09-01

    The automatic quality control (QC) procedures in order to indicate or filter out the wrong data are indispensable in the databases. However the development of such software systems is impossible without adequate and advanced mathematical fundament. During the last years we developed some software systems that are MASH (Multiple Analysis of Series for Homogenization) and MISH (Meteorological Interpolation based on Surface Homogenized Data Basis), with special attention for the strong mathematical basis. The MASH system can be used for homogenization of daily and monthly series, furthermore in the system also a quality control (QC) unit has been built for the daily data. Such QC can be an essential part of the homogenization methods which are examined nowadays within the COSTES0601 HOME action. The principle of the QC procedure built in MASH is certain multiple comparisons of the data by spatial interpolation technique and the analysis of interpolation errors for detection of wrong data is based on confidence intervals. In MASH system the necessary climate statistical parameters, such as expected values, spatial and temporal covariance structure, are estimated on the basis of examined data series by classic statistical way. The reason of development of the newer MISH system was that the usual applied interpolation methods built in GIS are able to use only a single realization in time for modelling the climate statistical parameters, while in meteorology we have long data series which form a sample in time and space as well. Nowadays we plan to implement the MASH QC procedure in MISH system as well. The main modification in MISH will be that modelled statistical parameters will be used during the QC procedure but in this case the quality control can be operated also for arbitrary single observation realization in time without long data series.

  12. A Robust Design Method in Product Quality Applications

    Institute of Scientific and Technical Information of China (English)

    ZHANG Shi-an

    2003-01-01

    In order to express information on the quality grade of product designed, the target value of product quality design was described with a fuzzy number in this paper. An alternative to Taguchi′s, the robustness application design method has been recently presented. However, neither Taguchi′s method nor the alternative method is capable of dealing satisfactorily with the frequently encountered situations in which all the noise variables cannot be studied simultaneously. Based on the ideas from response surface modeling, linear models theory, and random effects models, we provide a method for estimation in the robustness application design method in product quality applications. With this new method used, the high-quality ratio of the product designed could be increased, and the ability to resist the influence of various disturbing factors and noise factors could be enhanced.

  13. Modern methods of wine quality analysis

    Directory of Open Access Journals (Sweden)

    Галина Зуфарівна Гайда

    2015-06-01

    Full Text Available  In this paper physical-chemical and enzymatic methods of quantitative analysis of the basic wine components were reviewed. The results of own experiments were presented for the development of enzyme- and cell-based amperometric sensors on ethanol, lactate, glucose, arginine

  14. Validación de métodos analíticos para el control de calidad de naproxeno supositorios Validation of analytical methods for the quality control of Naproxen suppositories

    OpenAIRE

    Yaslenis Rodríguez Hernández; Yania Suárez Pérez; Oscar García Pulpeiro; Orestes Yuniel Hernández Contreras

    2011-01-01

    En el presente trabajo se desarrollaron por primera vez, los métodos de análisis que serán utilizados para el control de calidad de las futuras formulaciones de supositorios de naproxeno, para uso infantil y adulto de producción nacional. Se propuso un método por espectrofotometría ultravioleta directa, el cual resultó específico, lineal, exacto y preciso para su aplicación en el control de calidad del naproxeno en supositorios, teniendo en cuenta la presencia de grupos cromóforos en su estru...

  15. [On-site quality control of acupuncture randomized controlled trial: design of content and checklist of quality control based on PICOST].

    Science.gov (United States)

    Li, Hong-Jiao; He, Li-Yun; Liu, Zhi-Shun; Sun, Ya-Nan; Yan, Shi-Yan; Liu, Jia; Zhao, Ye; Liu, Bao-Yan

    2014-02-01

    To effectively guarantee quality of randomized controlld trial (RCT) of acupuncture and develop reasonable content and checklist of on-site quality control, influencing factors on quality of acupuncture RCT are analyzed and scientificity of quality control content and feasibility of on-site manipulation are put into overall consideration. Based on content and checklist of on-site quality control in National 11th Five-Year Plan Project Optimization of Comprehensive Treatment Plan for TCM in Prevention and Treatment of Serious Disease and Clinical Assessment on Generic Technology and Quality Control Research, it is proposed that on-site quality control of acupuncture RCT should be conducted with PICOST (patient, intervention, comparison, out come, site and time) as core, especially on quality control of interveners' skills and outcome assessment of blinding, and checklist of on-site quality control is developed to provide references for undertaking groups of the project.

  16. Quality control in bio-monitoring networks, Spanish Aerobiology Network.

    Science.gov (United States)

    Oteros, Jose; Galán, Carmen; Alcázar, Purificación; Domínguez-Vilches, Eugenio

    2013-01-15

    Several of the airborne biological particles, such as pollen grains and fungal spores, are known to generate human health problems including allergies and infections. A number of aerobiologists have focused their research on these airborne particles. The Spanish Aerobiology Network (REA) was set up in 1992, and since then dozens of research groups have worked on a range of related topics, including the standardization of study methods and the quality control of data generated by this network. In 2010, the REA started work on an inter-laboratory survey for proficiency testing purposes. The main goal of the study reported in the present paper was to determine the performance of technicians in the REA network using an analytical method that could be implemented by other bio-monitoring networks worldwide. The results recorded by each technician were compared with the scores obtained for a bounded mean of all results. The performance of each technician was expressed in terms of the relative error made in counting each of several pollen types. The method developed and implemented here proved appropriate for proficiency testing in interlaboratory studies involving bio-monitoring networks, and enabled the source of data quality problems to be pinpointed. The test revealed a variation coefficient of 10%. The relative error was significant for 3.5% of observations. In overall terms, the REA staff performed well, in accordance with the REA Management and Quality Manual. These findings serve to guarantee the quality of the data obtained, which can reliably be used for research purposes and published in the media in order to help prevent pollen-related health problems.

  17. Quality control system response to stochastic growth of amyloid fibrils

    DEFF Research Database (Denmark)

    Pigolotti, Simone; Lizana, Ludvig; Otzen, Daniel

    2013-01-01

    We introduce a stochastic model describing aggregation of misfolded proteins and degradation by the protein quality control system in a single cell. Aggregate growth is contrasted by the cell quality control system, that attacks them at different stages of the growth process, with an efficiency t...

  18. 7 CFR 58.733 - Quality control tests.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Quality control tests. 58.733 Section 58.733... Procedures § 58.733 Quality control tests. (a) Chemical analyses. The following chemical analyses shall be... pasteurization by means of the phosphatase test, as well as any other tests necessary to assure good...

  19. 75 FR 41874 - Quality Control for Rental Assistance Subsidy Determinations

    Science.gov (United States)

    2010-07-19

    ... URBAN DEVELOPMENT Quality Control for Rental Assistance Subsidy Determinations AGENCY: Office of the.... This notice also lists the following information: Title of Proposal: Quality Control for Rental... agency's estimate of the burden of the proposed collection of information; (3) Enhance the...

  20. Artificial Intelligence Approach to Support Statistical Quality Control Teaching

    Science.gov (United States)

    Reis, Marcelo Menezes; Paladini, Edson Pacheco; Khator, Suresh; Sommer, Willy Arno

    2006-01-01

    Statistical quality control--SQC (consisting of Statistical Process Control, Process Capability Studies, Acceptance Sampling and Design of Experiments) is a very important tool to obtain, maintain and improve the Quality level of goods and services produced by an organization. Despite its importance, and the fact that it is taught in technical and…

  1. Safety of timber: An analysis of quality control options

    NARCIS (Netherlands)

    Kovryga, A.; Stapel, P.; Van de Kuilen, J.W.G.

    2014-01-01

    The quality assurance of timber properties is important for the safety of timber structures. In the current study, the quality control options of timber are analysed under the prism of the different growth regions. Therefore, these options - machine and output control - are simulated in accordance w

  2. Quality control of geological voxel models using experts' gaze

    NARCIS (Netherlands)

    Maanen, van Peter-Paul; Busschers, Freek S.; Brouwer, Anne-Marie; Meulendijk, van der Michiel J.; Erp, van Jan B.F.

    2015-01-01

    Due to an expected increase in geological voxel model data-flow and user demands, the development of improved quality control for such models is crucial. This study explores the potential of a new type of quality control that improves the detection of errors by just using gaze behavior of 12 geologi

  3. Validación de métodos analíticos para el control de calidad de naproxeno supositorios Validation of analytical methods for the quality control of Naproxen suppositories

    National Research Council Canada - National Science Library

    Yaslenis Rodríguez Hernández; Yania Suárez Pérez; Oscar García Pulpeiro; Orestes Yuniel Hernández Contreras

    2011-01-01

    En el presente trabajo se desarrollaron por primera vez, los métodos de análisis que serán utilizados para el control de calidad de las futuras formulaciones de supositorios de naproxeno, para uso infantil y adulto...

  4. Contributions of CCLM to advances in quality control.

    Science.gov (United States)

    Kazmierczak, Steven C

    2013-01-01

    Abstract The discipline of laboratory medicine is relatively young when considered in the context of the history of medicine itself. The history of quality control, within the context of laboratory medicine, also enjoys a relatively brief, but rich history. Laboratory quality control continues to evolve along with advances in automation, measurement techniques and information technology. Clinical Chemistry and Laboratory Medicine (CCLM) has played a key role in helping disseminate information about the proper use and utility of quality control. Publication of important advances in quality control techniques and dissemination of guidelines concerned with laboratory quality control has undoubtedly helped readers of this journal keep up to date on the most recent developments in this field.

  5. How to set up and manage quality control and quality assurance

    NARCIS (Netherlands)

    Visschedijk, M.; Hendriks, R.; Nuyts, K.

    2005-01-01

    This document provides a general introduction to clarify the differences between quality control (QC) and quality assurance (QA). In addition it serves as a starting point for implementing a quality system approach within an organization. The paper offers practical guidance to the implementation of

  6. How to set up and manage quality control and quality assurance

    NARCIS (Netherlands)

    Visschedijk, M.; Hendriks, R.; Nuyts, K.

    2005-01-01

    This document provides a general introduction to clarify the differences between quality control (QC) and quality assurance (QA). In addition it serves as a starting point for implementing a quality system approach within an organization. The paper offers practical guidance to the implementation of

  7. Effect of uncertainty components such as recalibration on the performance of quality control charts

    DEFF Research Database (Denmark)

    Winkel, P; Zhang, Nevin

    2005-01-01

    Uncertainty components (recalibration, new reagent lots, etc.) may be the source of random changes in the level of quality control (QC) values, thus causing false alarms. We propose a method for reducing false alarms....

  8. A simple method of chaos control

    CERN Document Server

    Shahverdiev, E M

    1998-01-01

    A simple method to perform chaos control without the need of complex numerical and analytical calculations is proposed. The method works for dynamical systems with bounded solutions and in the trivial case of constant Jacobians.

  9. AMAZON RAINFOREST COSMETICS: CHEMICAL APPROACH FOR QUALITY CONTROL

    Directory of Open Access Journals (Sweden)

    Mariko Funasaki

    2016-02-01

    Full Text Available The market for natural cosmetics featuring ingredients derived from Amazon natural resources is growing worldwide. However, there is neither enough scientific basis nor quality control of these ingredients. This paper is an account of the chemical constituents and their biological activities of fourteen Amazonian species used in cosmetic industry, including açaí (Euterpe oleracea, andiroba (Carapa guianensis, bacuri (Platonia insignis, Brazil nut (Bertholletia excelsa, buriti (Mauritia vinifera or M. flexuosa, cumaru (Dipteryx odorata, cupuaçu (Theobroma grandiflorum, guarana (Paullinia cupana, mulateiro (Calycophyllum spruceanum, murumuru (Astrocaryum murumuru, patawa (Oenocarpus bataua or Jessenia bataua, pracaxi (Pentaclethra macroloba, rosewood (Aniba rosaeodora, and ucuuba (Virola sebifera. Based on the reviewed articles, we selected chemical markers for the quality control purpose and evaluated analytical methods. Even though chromatographic and spectroscopic methods are major analytical techniques in the studies of these species, molecular approaches will also be important as used in food and medicine traceability. Only a little phytochemical study is available about most of the Amazonian species and some species such as açaí and andiroba have many reports on chemical constituents, but studies on biological activities of isolated compounds and sampling with geographical variation are limited.

  10. Advanced control technology and airworthiness flying qualities requirements

    Science.gov (United States)

    Snyder, C. T.

    1976-01-01

    Flying quality requirements are specified in terms of the complete pilot-airframe-systems loop, the task, and the environment. Results from a study of flying qualities are reported. A review of the treatment of failure cases in various flying quality requirements is presented along with a description of the methods used and relevant lessons learned from recent Autoland certification programs.

  11. Evaluation of Design Methods for Geometric Control

    DEFF Research Database (Denmark)

    Kymmel, Mogens; Beran, M.; Foldager, L.;

    1985-01-01

    Geometric control can produce desirable control by decoupling the input disturbances from the selected output variables. The basic principle for this method was originally introduced by Wonham. The mathematical complexity involved, however, makes the method very hard to get accepted by the chemical...... community. The paper evaluates Wonham's original method together with three other methods, i.e. eigenvalue/eigenvector methods by Shah et al, the graph theory by Schizas and Evans and the simplified method by Kümmel et al. The evaluation considers the basic potential of the methods, the prerequisite...... of the designer, transparency, computer demand, and potential for pole shift....

  12. Videoregistration of surgery should be used as a quality control.

    Science.gov (United States)

    Koninckx, Philippe R

    2008-01-01

    Quality control of medical treatment is strictly organized and supervised. Efficacy and safety have to be proven in large randomized controlled trials, which need ethical review board approval. Content and quality of marketed drugs is controlled by industry and government. After market introduction, postmarketing surveillance is organized. This quality control is necessary to obtain reliable and predictable results and to detect even rare adverse events. Quality control of surgical treatments is close to nonexistent for individual surgical procedures and, therefore, rare adverse events cannot be detected by the sheer number of interventions analyzed. An ethical review board is rarely consulted before a new procedure is attempted or introduced. Although the outcome of surgery is surgeon and environment dependent, the only estimation of quality is results and complication rates. These, however, reflect publications by dedicated groups or data from surveys that do not necessarily reflect reality accurately. Complications are known to be under-reported whereas surveys reflect mean quality only. For most complication rates, it remains unknown which were preventable mistakes and which were unavoidable, random accidents. This huge discrepancy in quality control of medical and surgical therapies can be understood by specifics of each type of therapy. Strict quality control in surgery is, moreover, difficult to organize given that the outcome varies with the surgeon and surgical environment. Systematic videotaping of entire interventions has the potential of providing a quality control of surgery. This, moreover, has become technically feasible at low cost. In conclusion, we need to reflect and organize quality control in surgery. Systematic videotaping of entire procedures seems to be an inexpensive and easy way to organize this control.

  13. Evaluation of Controller Tuning Methods Applied to Distillation Column Control

    DEFF Research Database (Denmark)

    Nielsen, Kim; W. Andersen, Henrik; Kümmel, Professor Mogens

    1998-01-01

    of this is to examine whether ZN and BLT design yield satisfactory control of distillation columns. Further, PI controllers are tuned according to a proposed multivariable frequency domain method. A major conclusion is that the ZN tuned controllers yield undesired overshoot and oscillation and poor stability robustness...... properties. BLT tuning removes the overshoot and oscillation, however, at the expense of a more sluggish response. We conclude that if a simple control design is to be used, the BLT method should be referred compared to the ZN method. The frequency domain design approach presented yields a more proper trade...... off between oscillation, response time and stability robustness. However, this method is more complicated to use than the ZN and BLT methods. Moreover, it is shown that properly tuned diagonal PI controllers can provide performance and robustness properties which equal well tuned PI controllers...

  14. The Concept of a Method Ensuring Aeronautical Data Quality

    Directory of Open Access Journals (Sweden)

    Dudek Ewa

    2016-07-01

    Full Text Available The paper presents the concept of a method ensuring quality of aeronautical data. European Union (among others UE 73/2010 as well as international (among others ICAO Annex 15 regulations introduce a number of requirements regarding the quality and safety of aeronautical data. Those directives set up a complementary regulations system. However with their objective and scope they determine mainly the specifications and requirements that are to be implemented and compatible. Mentioned regulations also refer to selected international standards (e.g. ISO 19157, focused on quality and safety of geographic data and information. Nevertheless within the scope of considered regulations and norms no algorithms and methods of ensuring required quality in the process of aeronautical data collection and processing were determined. Taking into account the identified needs, authors proposed the application of statistical method for process quality management – six-sigma.

  15. Greenhouse climate control affects postharvest tomato quality

    NARCIS (Netherlands)

    Farneti, B.; Schouten, R.E.; Qian, T.; Dieleman, J.A.; Tijskens, L.M.M.; Woltering, E.J.

    2013-01-01

    In this study, important quality properties such as firmness, sugar and acid levels were measured and analysed in tomatoes harvested from three greenhouses during a five month period and stored at 16 degrees C for over 20 days. Tomatoes were harvested from three identical, neighbouring, greenhouses

  16. Internal quality audit and quality standards as a method of quality improvement at the Department of Ophthalmology, University Hospital.

    Science.gov (United States)

    Nasić, Mirjana; Pokupec, Rajko; Katusić, Damir; Miklić, Pavle; Suić, Ivan; Galić, Slobodan

    2005-01-01

    Quality assessment of clinical health care with the programme of quality standard is a method of health management, through which better efficiency and safety of health outcomes can be achieved. In the period from 2002 to 2004, a pilot program of quality has been carried out on the Department of Ophthalmology, University Hospital Center in Zagreb. Seven internal audit teams of hospital commission and teams of hospital departments were evaluating introducing practice for quality standards every three months. In the period of two years improvement in all standards of quality has been noticed (expressed in percent of progress towards the ideal result of 100%): personnel 20%, patient rights 15%, medical equipment 40%, quality of emergency service 60%, implementation of clinical guidelines and criteria for elective admission 55%, quality of risk prevention 70%, quality of medical records 60%. The two-years-improvement dynamics of about 46%, first year 24%.

  17. Design, analysis, and interpretation of field quality-control data for water-sampling projects

    Science.gov (United States)

    Mueller, David K.; Schertz, Terry L.; Martin, Jeffrey D.; Sandstrom, Mark W.

    2015-01-01

    The process of obtaining and analyzing water samples from the environment includes a number of steps that can affect the reported result. The equipment used to collect and filter samples, the bottles used for specific subsamples, any added preservatives, sample storage in the field, and shipment to the laboratory have the potential to affect how accurately samples represent the environment from which they were collected. During the early 1990s, the U.S. Geological Survey implemented policies to include the routine collection of quality-control samples in order to evaluate these effects and to ensure that water-quality data were adequately representing environmental conditions. Since that time, the U.S. Geological Survey Office of Water Quality has provided training in how to design effective field quality-control sampling programs and how to evaluate the resultant quality-control data. This report documents that training material and provides a reference for methods used to analyze quality-control data.

  18. Research on the homogenization evaluation method of cigarette based on multivariate quality control limit%基于多元质量控制限的卷烟均质化评价方法研究

    Institute of Scientific and Technical Information of China (English)

    石凤学; 王晓辉; 张涛; 张强; 王浩雅; 孙力; 陈冉; 邹泉; 王理珉; 李红武

    2013-01-01

    为探讨多点生产卷烟产品多指标相似性评价方法,对2个卷烟品牌A(三类烟)、B(四类烟)在2009~2010年的常规质量检测数据中的三个烟气成分指标(焦油、烟气烟碱、CO),进行相似性评价,计算其马氏相似系数和Hotelling T2统计量.通过建立两个品牌马氏相似系数与Hotelling T2统计量之间的曲线回归模型,确定出两个牌号各生产厂家相似性控制限的置信水平和σ倍数.结果表明:A牌号(三类烟)各生产厂家在焦油、烟气烟碱和CO三个指标上的相似性控制限置信水平为0.999 999 998 985 879,σ为6.107 171 74倍;B牌号(四类烟)各生产厂家在焦油、烟气烟碱和CO上的相似性控制限置信水平为0.999 999 999 517,σ为6.224 531倍.该相似性控制限的提出为多点生产卷烟产品多指标相似性评价提供方法.%In order to explore the evaluation method for multiple indexes with same brand cigarette from multi-point production, 3 indexes(Tar, nicotine, CO) values of the cigarette of A brand(third kind of cigarettes) and B brand(fourth kind of cigarettes) from the regular quality during 2009~2010 was evaluated in the similarity. The curve regression models of two brands are established by caculated Mahalanob similarity coefficient and Hotelling T2 statistic. Finally, the Control Limit (confidence level and times of σ) of similarity with two brands is determined thourgh established models. The results showed that the Control Limit confidence level is 0. 999 999 998 985 879 and 6. 107 171 74 times of σ in 3 indexes (Tar, nicotine, CO) of the cigarette of A brand (third kind of cigarettes)from multi-point production, and the Control Limit confidence level is 0. 999 999 999 517 and 6. 224 531 times of σ in 3 in-dexes(Tar, nicotine, CO)of the cigarette of B brand(fourth kind of cigarettes)from multipoint production. Based on the Control Limit of similarity with two brands is determined,which provides a method for evaluating

  19. PROCESS VARIABILITY REDUCTION THROUGH STATISTICAL PROCESS CONTROL FOR QUALITY IMPROVEMENT

    Directory of Open Access Journals (Sweden)

    B.P. Mahesh

    2010-09-01

    Full Text Available Quality has become one of the most important customer decision factors in the selection among the competing product and services. Consequently, understanding and improving quality is a key factor leading to business success, growth and an enhanced competitive position. Hence quality improvement program should be an integral part of the overall business strategy. According to TQM, the effective way to improve the Quality of the product or service is to improve the process used to build the product. Hence, TQM focuses on process, rather than results as the results are driven by the processes. Many techniques are available for quality improvement. Statistical Process Control (SPC is one such TQM technique which is widely accepted for analyzing quality problems and improving the performance of the production process. This article illustrates the step by step procedure adopted at a soap manufacturing company to improve the Quality by reducing process variability using Statistical Process Control.

  20. Color management systems: methods and technologies for increased image quality

    Science.gov (United States)

    Caretti, Maria

    1997-02-01

    All the steps in the imaging chain -- from handling the originals in the prepress to outputting them on any device - - have to be well calibrated and adjusted to each other, in order to reproduce color images in a desktop environment as accurate as possible according to the original. Today most of the steps in the prepress production are digital and therefore it is realistic to believe that the color reproduction can be well controlled. This is true thanks to the last years development of fast, cost effective scanners, digital sources and digital proofing devices not the least. It is likely to believe that well defined tools and methods to control this imaging flow will lead to large cost and time savings as well as increased overall image quality. Until now, there has been a lack of good, reliable, easy-to- use systems (e.g. hardware, software, documentation, training and support) in an extent that has made them accessible to the large group of users of graphic arts production systems. This paper provides an overview of the existing solutions to manage colors in a digital pre-press environment. Their benefits and limitations are discussed as well as how they affect the production workflow and organization. The difference between a color controlled environment and one that is not is explained.

  1. Development and approbation methods of complex estimation of flexo extrusion packaging quality

    Directory of Open Access Journals (Sweden)

    Manakov Volodymyr

    2016-04-01

    Full Text Available The article considers the issues of quality control of tube packing. For determination of the quality level of the packing, printed by flexographic printing a complex method is used. This method allows to identify the most significant parameters, which influence the printing quality. The basic unit parameters are: dot gain, misalignment of colors, changing the overall contrast, deviation by color. Expert method, based on the survey of employees of printing companies who are professionals in the field of packaging and label flexographic printing, is used for determination of the weighting coefficients of quality indicators. Complex evaluation of printing quality allows to connect visual evaluation, instrumental, and physical indicators of tube packing quality.

  2. NIF Projects Controls and Information Systems Software Quality Assurance Plan

    Energy Technology Data Exchange (ETDEWEB)

    Fishler, B

    2011-03-18

    Quality achievement for the National Ignition Facility (NIF) and the National Ignition Campaign (NIC) is the responsibility of the NIF Projects line organization as described in the NIF and Photon Science Directorate Quality Assurance Plan (NIF QA Plan). This Software Quality Assurance Plan (SQAP) is subordinate to the NIF QA Plan and establishes quality assurance (QA) activities for the software subsystems within Controls and Information Systems (CIS). This SQAP implements an activity level software quality assurance plan for NIF Projects as required by the LLNL Institutional Software Quality Assurance Program (ISQAP). Planned QA activities help achieve, assess, and maintain appropriate quality of software developed and/or acquired for control systems, shot data systems, laser performance modeling systems, business applications, industrial control and safety systems, and information technology systems. The objective of this SQAP is to ensure that appropriate controls are developed and implemented for management planning, work execution, and quality assessment of the CIS organization's software activities. The CIS line organization places special QA emphasis on rigorous configuration control, change management, testing, and issue tracking to help achieve its quality goals.

  3. The Robust Control Mixer Module Method for Control Reconfiguration

    DEFF Research Database (Denmark)

    Yang, Z.; Blanke, M.

    1999-01-01

    of the reconfigurated system simultaneously, and to deal with a more general controller reconfiguration than the static feedback mechanism by using the control mixer approach, the robust control mixer module method is proposed in this paper. The form of the control mixer module extends from a static gain matrix......The control mixer concept is efficient in improving an ordinary control system into a fault tolerant one, especially for these control systems of which the real-time and on-line redesign of the control laws is very difficult. In order to consider the stability, performance and robustness...... into a LTI dynamical system, and furthermore multiple dynamical control mixer modules can be employed in our consideration. The H_{\\infty} control theory is used for the analysis and design of the robust control mixer modules. Finally, one practical robot arm system as benchmark is used to test the proposed...

  4. Airfoil Roll Control by Bang-Bang Optimal Control Method with Plasma Actuators

    CERN Document Server

    Wei, Qingkai; Chen, Bao; Huang, Xun

    2012-01-01

    The bang-bang optimal control method was proposed for glow discharge plasma actuators, taking account of practical issues, such as limited actuation states with instantaneously varied aerodynamic control performance. Hence, the main contribution of this Note is to integrate flight control with active flow control in particular for plasma actuators. Flow control effects were examined in wind tunnel experiments, which show that the plasma authority for flow control is limited. Flow control effects are only obvious at pitch angles near stall. However, flight control simulations suggest that even those small plasma-induced roll moments can satisfactorily fulfill the maneuver tasks and meet flight quality specifications. In addition, the disturbance from volatile plasma-induced roll moments can be rejected. Hence, the proposed bang-bang control method is a promising candidate of control design methodology for plasma actuators.

  5. Adaptive Method Using Controlled Grid Deformation

    Directory of Open Access Journals (Sweden)

    Florin FRUNZULICA

    2011-09-01

    Full Text Available The paper presents an adaptive method using the controlled grid deformation over an elastic, isotropic and continuous domain. The adaptive process is controlled with the principal strains and principal strain directions and uses the finite elements method. Numerical results are presented for several test cases.

  6. New regulatory framework for wastewater quality control in Mexico.

    Science.gov (United States)

    Saade Hazin, L

    2000-01-01

    This paper analyses the new regulatory framework for wastewater quality control developed in Mexico. It provides a description of the Mexican government strategies for water pollution control. The discussion focuses on the policy instruments used, their evolution and the main difficulties encountered in their implementation. The new regulatory framework is discussed highlighting some of the economic implications of the reforms. The paper concludes that proper institutional development and monitoring are essential factors for the success of any policy instrument for wastewater quality control.

  7. Implementation of Quality Assurance and Quality Control Measures in the National Phenology Database

    Science.gov (United States)

    Gerst, K.; Rosemartin, A.; Denny, E. G.; Marsh, L.; Barnett, L.

    2015-12-01

    The USA National Phenology Network (USA-NPN; www.usanpn.org) serves science and society by promoting a broad understanding of plant and animal phenology and the relationships among phenological patterns and environmental change. The National Phenology Database has over 5.5 million observation records for plants and animals for the period 1954-2015. These data have been used in a number of science, conservation and resource management applications, including national assessments of historical and potential future trends in phenology, regional assessments of spatio-temporal variation in organismal activity, and local monitoring for invasive species detection. Customizable data downloads are freely available, and data are accompanied by FGDC-compliant metadata, data-use and data-attribution policies, and vetted documented methodologies and protocols. The USA-NPN has implemented a number of measures to ensure both quality assurance and quality control. Here we describe the resources that have been developed so that incoming data submitted by both citizen and professional scientists are reliable; these include training materials, such as a botanical primer and species profiles. We also describe a number of automated quality control processes applied to incoming data streams to optimize data output quality. Existing and planned quality control measures for output of raw and derived data include: (1) Validation of site locations, including latitude, longitude, and elevation; (2) Flagging of records that conflict for a given date for an individual plant; (3) Flagging where species occur outside known ranges; (4) Flagging of records when phenophases occur outside of the plausible order for a species; (5) Flagging of records when intensity measures do not follow a plausible progression for a phenophase; (6) Flagging of records when a phenophase occurs outside of the plausible season, and (7) Quantification of precision and uncertainty for estimation of phenological metrics

  8. Developing and executing quality improvement projects (concept, methods, and evaluation).

    Science.gov (United States)

    Likosky, Donald S

    2014-03-01

    Continuous quality improvement, quality assurance, cycles of change--these words of often used to express the process of using data to inform and improve clinical care. Although many of us have been exposed to theories and practice of experimental work (e.g., randomized trial), few of us have been similarly exposed to the science underlying quality improvement. Through the lens of a single-center quality improvement study, this article exposes the reader to methodology for conducting such studies. The reader will gain an understanding of these methods required to embark on such a study.

  9. A bootstrap method for estimating uncertainty of water quality trends

    Science.gov (United States)

    Hirsch, Robert M.; Archfield, Stacey A.; DeCicco, Laura

    2015-01-01

    Estimation of the direction and magnitude of trends in surface water quality remains a problem of great scientific and practical interest. The Weighted Regressions on Time, Discharge, and Season (WRTDS) method was recently introduced as an exploratory data analysis tool to provide flexible and robust estimates of water quality trends. This paper enhances the WRTDS method through the introduction of the WRTDS Bootstrap Test (WBT), an extension of WRTDS that quantifies the uncertainty in WRTDS-estimates of water quality trends and offers various ways to visualize and communicate these uncertainties. Monte Carlo experiments are applied to estimate the Type I error probabilities for this method. WBT is compared to other water-quality trend-testing methods appropriate for data sets of one to three decades in length with sampling frequencies of 6–24 observations per year. The software to conduct the test is in the EGRETci R-package.

  10. Methods of multicriterion estimations in system total quality management

    Directory of Open Access Journals (Sweden)

    Nikolay V. Diligenskiy

    2011-05-01

    Full Text Available In this article the method of multicriterion comparative estimation of efficiency (Data Envelopment Analysis and possibility of its application in system of total quality management is considered.

  11. Ripening stage and drying method affecting colour and quality ...

    African Journals Online (AJOL)

    STORAGESEVER

    Key words: Ber, drying method, post harvest quality, blanching, fruit colour, harvesting stage. ... ground following abscission, throwing stones and sticks into the trees, hitting ... of insect larva inside each individual fruits. .... Climate change and.

  12. Totally Carrying out Zero Defects Quality Control

    Institute of Scientific and Technical Information of China (English)

    ZhangQingwei; CASCPresident

    2004-01-01

    Editorial note: On March 22,1992 the launch of LM-2E launch vehicle with an Australian satellite was terminated. A piece of 0.15 milligram aluminum redundance led to the malfunction of the program distributor, which caused the emergency cutoff after 7 seconds of the ignition of the rocket. To bear in mind the painful lesson, China Aerospace Corporation set out March 22 to be “Space Quality Day” in 1994.

  13. Particle electrophoresis for quality assurance and process control.

    Science.gov (United States)

    Seaman, G V; Knox, R J

    2001-02-01

    Process control is an increasingly important issue as life science companies world-wide strive for recognition of their manufacturing and product development quality measures according to International Standards Organization (ISO) or good manufacturing practices (GMP) standards. Analytical particle electrophoresis (APE) has the potential for significant contributions, not just to basic research, but also in process development and control in manufacturing environments. An important feature of colloidal (small) particles, which controls their behavior, is their surface charge. Optimization of life science products and process conditions involving small particles (>100 nm) may be approached by a variety of strategies based upon direct measurements of the charge properties of process particles or "reporter" particles. The availability of increasingly powerful instruments and control particle preparations (National Institute of Standards and Technology ((NIST) and others) for validation of instrument operation make the method more attractive than ever. We summarize highly flexible electrophoretic strategies for assessing process consistency both from the perspective of particles being processed as well as the processing environment and describe principles for the use of polymer microspheres both as control particles for validation of instrument operation as well as for probes of the assay medium.

  14. Methods Reduce Cost, Enhance Quality of Nanotubes

    Science.gov (United States)

    2009-01-01

    efforts with carbon nanotubes have made it a global leader in this field. Among the many examples are Johnson Space Center s Carbon Nanotube Project, which focuses on bulk nanotube production, purification, and application, and Goddard Space Flight Center s improved arc discharge method of nanotube production, developed under the direction of Jeannette Benavides (featured in Spinoff 2007 and 2008). While the Agency continues its own research, it partners with private companies to advance this unique technology for use on Earth as well as among the stars.

  15. A cooperative control strategy of resistance spot welding process by combining the constant current control with the DRC method

    Institute of Scientific and Technical Information of China (English)

    Li Guizhong; Wang Changzheng; Kong Meng; Guo Caiguang

    2009-01-01

    The modeling control method based on the dynamic resistance characteristics of good nuggets, that is the DRC method, is an improvement on the dynamic resistance threshold method for the quality control of resistance spot welding. But there is still a control blind area in the initial four cycles. For this reason, the quality of every weld nugget could not be fully ensured. Thus a new fuzzy cooperative control method is put forward. It uses a multi-information time-control mechanism by combining the constant current control technology with the DRC method in a relay way. This whole-process control strategy has led to a good control effect and produced the dual-identicul results in the weld nugget quality and the welding time.

  16. METHODS OF CONTROL DIPHTHERIA VACCINE SAFETY

    Directory of Open Access Journals (Sweden)

    Isayenko Ye. Yu

    2016-12-01

    Full Text Available Vaccination success depends not only on the timely coverage of threatened contingents, but also on the quality of vaccines. Every day, the requirements for security guarantees vaccines and their use guarantees of security increases. For the fast, reliable and independent scientific assessment of vaccine safety issues, WHO in 1999 created the Global Advisory Committee on Vaccine Safety. To enhance the capacity of pharmaceutical supervision in relation to vaccines in 2012 it was developed the Global Vaccine Safety Initiative. The main directions of the Global Vaccine Safety programs are considered in this review. It’s noted more strict requirements of Ukrainian pharmaceutical industry to produce public immunization drugs regulated Supplements to the State Pharmacopoeia of Ukraine, in comparison with other countries. This review considered diphtheria vaccine safety monitoring in the process of production according to the recommendations of the World Health Organization (WHO, described a subcutaneous method for determining the specific toxicity of the combined purified toxoid, characterized an intracutaneous method of determining of the presence of diphtheria toxin in each sample of the combined purified toxoid, that additionally used by some manufacturers. The definition of diphtheria toxin in dilutions of purified toxoid is presented. This review considered diphtheria vaccine safety monitoring in the process of production according to the recommendations of the World Health Organization (WHO, described a subcutaneous method for determining the specific toxicity of the combined purified toxoid, characterized an intracutaneous method of determining of the presence of diphtheria toxin in each sample of the combined purified toxoid, that additionally used by some manufacturers. The definition of diphtheria toxin in dilutions of purified toxoid is presented. As methods for determination of diphtheria toxin must be able to detect even a small amount

  17. Radiation dose reduction without degrading image quality during computed tomography examinations: Dosimetry and quality control study

    Directory of Open Access Journals (Sweden)

    George Felix Acquah

    2014-08-01

    Full Text Available Purpose: Computed tomography (CT, is an X-ray procedure that generates high quality cross-sectional images of the body, and by comparison to other radiological diagnosis, is responsible for higher doses to patients. This work studies the doses and image qualities produced from the default primary scanning factors of a Siemens CT machine and afterwards came up with scanning protocols that allow radiologists to obtain the necessary diagnostic information while reducing radiation doses to as low as reasonably achievable. Methods: Approximately 1000 CT scans from mostly common examinations; head, thorax, abdomen and pelvis routines were selected and analyzed for their image quality and radiation doses over a two year interval. Dose measurements were performed for the same routines using Computed Tomography Dose Index (CTDI phantoms, RTI barracuda system with electrometer, and CT dose Profiler detector to evaluate the doses delivered during these CT procedures. Subsequently, image quality checks were performed using the CT Catphan 600 and anthropomorphic phantoms. CTDI and Dose Length Product (DLP values were calculated for each scan. From analyzing these measurements, the appropriate machine scanning parameters were adjusted to reduce radiation does while at the same time providing good image quality.Results: Doses to patients using the default head sequence protocol had an average CTDIvol value of 65.45 mGy and a range of 7.10-16.80 mGy for thorax, abdomen and pelvis examinations whiles the new protocol had an average CTDIvol of 58.32 mGy for the head and a range of 3.83-15.24 mGy for the truck region. The DLP value for default head scans decreased from an average of 2279.85 mGy.cm to 874.53 mGy.cm with the new protocol. Tube potentials (KV and tube current-time (mAs had an effect on spatial resolution and low contrast detectability as well as doses. Conclusion: From the new protocols, lower values of KV and mAs together with other factors were

  18. A Robust Tolerance Design Method Based on Fuzzy Quality Loss

    Institute of Scientific and Technical Information of China (English)

    CAO Yan-long; MAO Jian; YANG Jiang-xin; WU Zhao-tong; WU Li-qun

    2006-01-01

    The traditional tolerance design model ignores the impact of noise factor,so that the design may be infeasible due to variations in design constraints.Based on the analysis of fuzzy factors in tolerance design and the limitations ofthe traditional Taguchi squared quality loss function,a fuzzy quality loss function model utilizing fuzzy theory was introduced.Concepts on fuzzy quality loss and fuzzy quality loss cost were proposed in the model.The characteristics of the new model and the advantages over the traditional Taguchi quality loss function were analyzed.A robust tolerance design model using a fuzzy quality loss function was proposed.An example was given to illustrate the proposed model.Results and comparisons show that the method is suitable and reliable,and makes the conclusions more objective and reasonable.

  19. Combined Control Scheme for Monitoring Quality Characteristics

    Directory of Open Access Journals (Sweden)

    Adekeye K.S.

    2014-07-01

    Full Text Available In the literature, the Exponentially Weighted Moving Average (EWMA and Exponentially Weighted Moving Variance (EMWV control schemes have been used separately to monitor the process average and process variability respectively. Here the two are combined and applied on simulated process with different level of variation. The control limit interval (CLI and the average run length (ARL were evaluated for the combined chart. The combined chart performed better than the two independently. Furthermore, an algorithm was developed for the two control charts and implemented on visual basic VB6.0. The obtained results show that the combined EWMA and EWMV control chart is very sensitive in detecting shift in production process and every shift in the process mean is always preceded by shift in the process variability.

  20. Web-based X-ray quality control documentation.

    Science.gov (United States)

    David, George; Burnett, Lou Ann; Schenkel, Robert

    2003-01-01

    The department of radiology at the Medical College of Georgia Hospital and Clinics has developed an equipment quality control web site. Our goal is to provide immediate access to virtually all medical physics survey data. The web site is designed to assist equipment engineers, department management and technologists. By improving communications and access to equipment documentation, we believe productivity is enhanced. The creation of the quality control web site was accomplished in three distinct steps. First, survey data had to be placed in a computer format. The second step was to convert these various computer files to a format supported by commercial web browsers. Third, a comprehensive home page had to be designed to provide convenient access to the multitude of surveys done in the various x-ray rooms. Because we had spent years previously fine-tuning the computerization of the medical physics quality control program, most survey documentation was already in spreadsheet or database format. A major technical decision was the method of conversion of survey spreadsheet and database files into documentation appropriate for the web. After an unsatisfactory experience with a HyperText Markup Language (HTML) converter (packaged with spreadsheet and database software), we tried creating Portable Document Format (PDF) files using Adobe Acrobat software. This process preserves the original formatting of the document and takes no longer than conventional printing; therefore, it has been very successful. Although the PDF file generated by Adobe Acrobat is a proprietary format, it can be displayed through a conventional web browser using the freely distributed Adobe Acrobat Reader program that is available for virtually all platforms. Once a user installs the software, it is automatically invoked by the web browser whenever the user follows a link to a file with a PDF extension. Although no confidential patient information is available on the web site, our legal

  1. Production Quality Control Of Microfluidic Chip Designs

    DEFF Research Database (Denmark)

    Calaon, Matteo; Hansen, Hans Nørgaard; Tosello, Guido

    2012-01-01

    -beam lithography. Subsequent nickel electroplating was employed to replicate the obtained geometries on the tool, which was used to mold on transparent polymer substrates the functional structures. To assess the critical factors affecting the replication quality throughout the different steps of the proposed...... process chain, test geometries were designed and produced on the side of the functional features. The so called “Finger Print” of the lithography and molding processes was qualitatively and quantitatively evaluated through scanning electron microscopy and atomic force microscopy respectively. The entire...

  2. Nonlinear system compound inverse control method

    Institute of Scientific and Technical Information of China (English)

    Yan ZHANG; Zengqiang CHEN; Peng YANG; Zhuzhi YUAN

    2005-01-01

    A compound neural network is utilized to identify the dynamic nonlinear system.This network is composed of two parts: one is a linear neural network,and the other is a recurrent neural network.Based on the inverse theory a compound inverse control method is proposed.The controller has also two parts:a linear controller and a nonlinear neural network controller.The stability condition of the closed-loop neural network-based compound inverse control system is demonstrated based on the Lyapunov theory.Simulation studies have shown that this scheme is simple and has good control accuracy and robustness.

  3. CTEPP STANDARD OPERATING PROCEDURE FOR CONDUCTING INTERNAL FIELD AUDITS AND QUALITY CONTROL (SOP-2.25)

    Science.gov (United States)

    This SOP describes the method for conducting internal field audits and quality control procedures. Internal field audits will be conducted to ensure the collection of high quality data. Internal field audits will be conducted by Field Auditors (the Field QA Officer and the Field...

  4. CTEPP STANDARD OPERATING PROCEDURE FOR CONDUCTING INTERNAL FIELD AUDITS AND QUALITY CONTROL (SOP-2.25)

    Science.gov (United States)

    This SOP describes the method for conducting internal field audits and quality control procedures. Internal field audits will be conducted to ensure the collection of high quality data. Internal field audits will be conducted by Field Auditors (the Field QA Officer and the Field...

  5. Web quality control for lectures: Supercourse and Amazon.com.

    Science.gov (United States)

    Linkov, Faina; LaPorte, Ronald; Lovalekar, Mita; Dodani, Sunita

    2005-12-01

    Peer review has been at the corner stone of quality control of the biomedical journals in the past 300 years. With the emergency of the Internet, new models of quality control and peer review are emerging. However, such models are poorly investigated. We would argue that the popular system of quality control used in Amazon.com offers a way to ensure continuous quality improvement in the area of research communications on the Internet. Such system is providing an interesting alternative to the traditional peer review approaches used in the biomedical journals and challenges the traditional paradigms of scientific publishing. This idea is being explored in the context of Supercourse, a library of 2,350 prevention lectures, shared for free by faculty members from over 150 countries. Supercourse is successfully utilizing quality control approaches that are similar to Amazon.com model. Clearly, the existing approaches and emerging alternatives for quality control in scientific communications needs to be assessed scientifically. Rapid explosion of internet technologies could be leveraged to produce better, more cost effective systems for quality control in the biomedical publications and across all sciences.

  6. Use of quality planning methods in optimizing welding wire quality characteristics

    Directory of Open Access Journals (Sweden)

    D. Vykydal

    2013-10-01

    Full Text Available The quality of a product is given by the extent, to which the product meets customer requirements. It is generally accepted that the extent, to which the product meets such customer requirements, and, consequently, the resulting quality of the product itself, substantially depend on the early stages of the product lifecycle, i.e. on the design and development stages. Appropriate means for effective product quality planning can be found among quality management methods and tools. These methods are typically employed in engineering production and automotive industry. This paper focuses on exploring the potential of Quality Function Deployment (QFD and Failure Mode and Effect Analysis (FMEA methods for use in metallurgical production, an industrial branch where they have not been commonly employed as yet.

  7. Air quality management in the WHO European Region--results of a quality assurance and control programme on air quality monitoring (1994-2004).

    Science.gov (United States)

    Mücke, Hans-Guido

    2008-07-01

    Since the last decade the WHO Collaborating Centre for Air Quality Management and Air Pollution Control, Berlin, Germany, operates a quality assurance and control (QA/QC) programme on air quality monitoring in the WHO European Region. As main activity Intercomparison workshops have been established for air monitoring network laboratories on a regular basis to harmonise air quality measurements, analysis and calibration techniques. 36 air hygiene laboratories of public health and environmental institutions of 24 countries participated in twelve Intercomparisons between 1994 and 2004. The majority was carried out for NO, NO(2), SO(2) and O(3). The results were predominantly satisfactory for automatic methods. The results of manual methods were mainly in a good, and for several concentration levels partly very good accordance with the data obtained by the monitors.

  8. Multivariate Statistical Process Control Process Monitoring Methods and Applications

    CERN Document Server

    Ge, Zhiqiang

    2013-01-01

      Given their key position in the process control industry, process monitoring techniques have been extensively investigated by industrial practitioners and academic control researchers. Multivariate statistical process control (MSPC) is one of the most popular data-based methods for process monitoring and is widely used in various industrial areas. Effective routines for process monitoring can help operators run industrial processes efficiently at the same time as maintaining high product quality. Multivariate Statistical Process Control reviews the developments and improvements that have been made to MSPC over the last decade, and goes on to propose a series of new MSPC-based approaches for complex process monitoring. These new methods are demonstrated in several case studies from the chemical, biological, and semiconductor industrial areas.   Control and process engineers, and academic researchers in the process monitoring, process control and fault detection and isolation (FDI) disciplines will be inter...

  9. Groundwater-quality and quality-control data for two monitoring wells near Pavillion, Wyoming, April and May 2012

    Science.gov (United States)

    Wright, Peter R.; McMahon, Peter B.; Mueller, David K.; Clark, Melanie L.

    2012-01-01

    In June 2010, the U.S. Environmental Protection Agency installed two deep monitoring wells (MW01 and MW02) near Pavillion, Wyoming, to study groundwater quality. During April and May 2012, the U.S Geological Survey, in cooperation with the Wyoming Department of Environmental Quality, collected groundwater-quality data and quality-control data from monitoring well MW01 and, following well redevelopment, quality-control data for monitoring well MW02. Two groundwater-quality samples were collected from well MW01—one sample was collected after purging about 1.5 borehole volumes, and a second sample was collected after purging 3 borehole volumes. Both samples were collected and processed using methods designed to minimize atmospheric contamination or changes to water chemistry. Groundwater-quality samples were analyzed for field water-quality properties (water temperature, pH, specific conductance, dissolved oxygen, oxidation potential); inorganic constituents including naturally occurring radioactive compounds (radon, radium-226 and radium-228); organic constituents; dissolved gasses; stable isotopes of methane, water, and dissolved inorganic carbon; and environmental tracers (carbon-14, chlorofluorocarbons, sulfur hexafluoride, tritium, helium, neon, argon, krypton, xenon, and the ratio of helium-3 to helium-4). Quality-control sample results associated with well MW01 were evaluated to determine the extent to which environmental sample analytical results were affected by bias and to evaluate the variability inherent to sample collection and laboratory analyses. Field documentation, environmental data, and quality-control data for activities that occurred at the two monitoring wells during April and May 2012 are presented.

  10. Advancement in modern approaches to mineral production quality control

    Science.gov (United States)

    Freidina, EV; Botvinnik, AA; Dvornikova, AN

    2017-02-01

    The natural resource potential of mineral deposits is represented by three categories: upside, attainable and investment. A modern methodology is proposed in this paper for production quality control, and its tools aimed at ensuring agreement between the product quality and the market requirements are described. The definitions of the costs of the product quality compliance and incompliance with the consumer requirements are introduced; the latter is suggested to use in evaluating resource potential of mineral deposits at a certain degree of probability.

  11. Six Sigma Quality Management System and Design of Risk-based Statistical Quality Control.

    Science.gov (United States)

    Westgard, James O; Westgard, Sten A

    2017-03-01

    Six sigma concepts provide a quality management system (QMS) with many useful tools for managing quality in medical laboratories. This Six Sigma QMS is driven by the quality required for the intended use of a test. The most useful form for this quality requirement is the allowable total error. Calculation of a sigma-metric provides the best predictor of risk for an analytical examination process, as well as a design parameter for selecting the statistical quality control (SQC) procedure necessary to detect medically important errors. Simple point estimates of sigma at medical decision concentrations are sufficient for laboratory applications.

  12. A new method for calculation of an air quality index

    Energy Technology Data Exchange (ETDEWEB)

    Ilvessalo, P. [Finnish Meteorological Inst., Helsinki (Finland). Air Quality Dept.

    1995-12-31

    Air quality measurement programs in Finnish towns have expanded during the last few years. As a result of this it is more and more difficult to make use of all the measured concentration data. Citizens of Finnish towns are nowadays taking more of an interest in the air quality of their surroundings. The need to describe air quality in a simplified form has increased. Air quality indices permit the presentation of air quality data in such a way that prevailing conditions are more easily understandable than when using concentration data as such. Using an air quality index always means that some of the information about concentrations of contaminants in the air will be lost. How much information is possible to extract from a single index number depends on the calculation method. A new method for the calculation of an air quality index has been developed. This index always indicates the overstepping of an air quality guideline level. The calculation of this air quality index is performed using the concentrations of all the contaminants measured. The index gives information both about the prevailing air quality and also the short-term trend. It can also warn about the expected exceeding of guidelines due to one or several contaminants. The new index is especially suitable for the real-time monitoring and notification of air quality values. The behaviour of the index was studied using material from a measurement period in the spring of 1994 in Kaepylae, Helsinki. Material from a pre-operational period in the town of Oulu was also available. (author)

  13. Quality assurance and quality control of geochemical data—A primer for the research scientist

    Science.gov (United States)

    Geboy, Nicholas J.; Engle, Mark A.

    2011-01-01

    Geochemistry is a constantly expanding science. More and more, scientists are employing geochemical tools to help answer questions about the Earth and earth system processes. Scientists may assume that the responsibility of examining and assessing the quality of the geochemical data they generate is not theirs but rather that of the analytical laboratories to which their samples have been submitted. This assumption may be partially based on knowledge about internal and external quality assurance and quality control (QA/QC) programs in which analytical laboratories typically participate. Or there may be a perceived lack of time or resources to adequately examine data quality. Regardless of the reason, the lack of QA/QC protocols can lead to the generation and publication of erroneous data. Because the interpretations drawn from the data are primary products to U.S. Geological Survey (USGS) stakeholders, the consequences of publishing erroneous results can be significant. The principal investigator of a scientific study ultimately is responsible for the quality and interpretation of the project's findings, and thus must also play a role in the understanding, implementation, and presentation of QA/QC information about the data. Although occasionally ignored, QA/QC protocols apply not only to procedures in the laboratory but also in the initial planning of a research study and throughout the life of the project. Many of the tenets of developing a sound QA/QC program or protocols also parallel the core concepts of developing a good study: What is the main objective of the study? Will the methods selected provide data of enough resolution to answer the hypothesis? How should samples be collected? Are there known or unknown artifacts or contamination sources in the sampling and analysis methods? Assessing data quality requires communication between the scientists responsible for designing the study and those collecting samples, analyzing samples, treating data, and

  14. Forward SCT Module Assembly and Quality Control at IFIC Valencia

    CERN Document Server

    Mitsou, V A; Civera, J V; Costa, M J; Escobar, C; Fuster, J; García, C; García-Navarro, J E; González, F; González-Sevilla, S; Lacasta, C; Llosá, G; Martí i García, S; Miñano, M; Modesto, P; Nácher, J; Rodríguez-Oliete, R; Sánchez, F J; Sospedra, L; Strachko, V

    2007-01-01

    This note discusses the assembly and the quality control tests of 282 forward detector modules for the ATLAS Semiconductor Tracker assembled at the Instituto de Fisica Corpuscular (IFIC) in Valencia. The construction and testing procedures are outlined and the laboratory equipment is briefly described. Emphasis is given on the module quality achieved in terms of mechanical and electrical stability.

  15. Academic Quality Control in Nigerian Universities: Exploring Lecturers' Perceptions

    Science.gov (United States)

    Obiekezie, E. O.; Ejemot-Nwadiaro, R. I.; Essien, M. I.; Timothy, A. Essien

    2014-01-01

    The level of job performance, international comparability and competitiveness of Nigerian university graduates are burning issues. Consequently, the academic quality of Nigerian universities has come under severe criticism. Since university lecturers are key players in quality control in universities, this study explored their perceptions of…

  16. Academic Quality Control in Nigerian Universities: Exploring Lecturers' Perceptions

    Science.gov (United States)

    Obiekezie, E. O.; Ejemot-Nwadiaro, R. I.; Essien, M. I.; Timothy, A. Essien

    2014-01-01

    The level of job performance, international comparability and competitiveness of Nigerian university graduates are burning issues. Consequently, the academic quality of Nigerian universities has come under severe criticism. Since university lecturers are key players in quality control in universities, this study explored their perceptions of…

  17. Quality control for diagnostic oral microbiology laboratories in European countries

    NARCIS (Netherlands)

    Rautemaa-Richardson, R.; van der Reijden, W.A.; Dahlen, G.; Smith, A.J.

    2011-01-01

    Participation in diagnostic microbiology internal and external quality control (QC) processes is good laboratory practice and an essential component of a quality management system. However, no QC scheme for diagnostic oral microbiology existed until 2009 when the Clinical Oral Microbiology (COMB)

  18. Quality Control Review of the Defense Logistics Agency Audit Organization

    Science.gov (United States)

    2014-12-19

    all auditors are required to follow, and established an internal quality assurance division that performs ongoing, periodic assessments of work...audit organization performing audits or attestation engagements or both have an appropriate internal quality control system in place and undergo an...2010, the DLA OIG addressed our recommendation to implement official policies and procedures, which all auditors are required to follow. The DLA

  19. Does a "Level I Evidence" rating imply high quality of reporting in orthopaedic randomised controlled trials?

    OpenAIRE

    Sierevelt Inger N; Krips Rover; Struijs Peter AA; Poolman Rudolf W; Lutz Kristina H; Bhandari Mohit

    2006-01-01

    Abstract Background The Levels of Evidence Rating System is widely believed to categorize studies by quality, with Level I studies representing the highest quality evidence. We aimed to determine the reporting quality of Randomised Controlled Trials (RCTs) published in the most frequently cited general orthopaedic journals. Methods Two assessors identified orthopaedic journals that reported a level of evidence rating in their abstracts from January 2003 to December 2004 by searching the instr...

  20. Research methods of simulate digital compensators and autonomous control systems

    Directory of Open Access Journals (Sweden)

    V. S. Kudryashov

    2016-01-01

    Full Text Available The peculiarity of the present stage of development of the production is the need to control and regulate a large number of process parameters, the mutual influence on each other that when using single-circuit systems significantly reduces the quality of the transition process, resulting in significant costs of raw materials and energy, reduce the quality of the products. Using a stand-alone digital control system eliminates the correlation of technological parameters, to give the system the desired dynamic and static properties, improve the quality of regulation. However, the complexity of the configuration and implementation of procedures (modeling compensators autonomous systems of this type, associated with the need to perform a significant amount of complex analytic transformation significantly limit the scope of their application. In this regard, the approach based on the decompo sition proposed methods of calculation and simulation (realization, consisting in submitting elements autonomous control part digital control system in a series parallel connection. The above theoretical study carried out in a general way for any dimension systems. The results of computational experiments, obtained during the simulation of the four autonomous control systems, comparative analysis and conclusions on the effectiveness of the use of each of the methods. The results obtained can be used in the development of multi-dimensional process control systems.