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Sample records for q enhancement

  1. Plasma surface interactions in Q-enhanced mirror systems

    International Nuclear Information System (INIS)

    Post, R.F.

    1978-01-01

    Two approaches to enhancement of the Q (energy gain) factor of mirror systems are under study at Livermore. These include the Tandem Mirror and the Field Reversed Mirror. Both of these new ideas preserve features of conventional mirror systems as far as plasma-wall interactions are concerned. Specifically in both approaches field lines exit from the ends of the system and impinge on walls located at a distance from the confinement chamber. It is possible to predict some aspects of the plasma/surface interactions of TM and FRM systems from experience obtained in the Livermore 2XIIB experiment. In particular, as observed in 2XIIB, effective isolation of the plasma from thermal contact with the ends owing to the development of sheath-like regions is to be expected. Studies presently underway directed toward still further enhancing the decoupling of the plasma from the effects of plasma surface interactions at the walls will be discussed, with particular reference to the problem of minimizing the effects of refluxing secondary electrons produced by plasma impact on the end walls

  2. Enhanced Ig production by human peripheral lymphocytes induced by aggregated C1q

    NARCIS (Netherlands)

    Daha, M. R.; Klar, N.; Hoekzema, R.; van Es, L. A.

    1990-01-01

    Because B cells express receptors for C1q, we have investigated the role of C1q in the stimulation of B cells. When B cells were cultured in the presence of C1q that had been frozen, T cells, and suboptimal concentrations of PWM, there was a dose-dependent enhancement of IgM, IgG, and IgA by the B

  3. K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism.

    Directory of Open Access Journals (Sweden)

    Atsuko Hachiya

    2011-01-01

    Full Text Available HIV-1 carrying the "Q151M complex" reverse transcriptase (RT mutations (A62V/V75I/F77L/F116Y/Q151M, or Q151Mc is resistant to many FDA-approved nucleoside RT inhibitors (NRTIs, but has been considered susceptible to tenofovir disoproxil fumarate (TFV-DF or TDF. We have isolated from a TFV-DF-treated HIV patient a Q151Mc-containing clinical isolate with high phenotypic resistance to TFV-DF. Analysis of the genotypic and phenotypic testing over the course of this patient's therapy lead us to hypothesize that TFV-DF resistance emerged upon appearance of the previously unreported K70Q mutation in the Q151Mc background. Virological analysis showed that HIV with only K70Q was not significantly resistant to TFV-DF. However, addition of K70Q to the Q151Mc background significantly enhanced resistance to several approved NRTIs, and also resulted in high-level (10-fold resistance to TFV-DF. Biochemical experiments established that the increased resistance to tenofovir is not the result of enhanced excision, as K70Q/Q151Mc RT exhibited diminished, rather than enhanced ATP-based primer unblocking activity. Pre-steady state kinetic analysis of the recombinant enzymes demonstrated that addition of the K70Q mutation selectively decreases the binding of tenofovir-diphosphate (TFV-DP, resulting in reduced incorporation of TFV into the nascent DNA chain. Molecular dynamics simulations suggest that changes in the hydrogen bonding pattern in the polymerase active site of K70Q/Q151Mc RT may contribute to the observed changes in binding and incorporation of TFV-DP. The novel pattern of TFV-resistance may help adjust therapeutic strategies for NRTI-experienced patients with multi-drug resistant (MDR mutations.

  4. Enhancing time resolution by stabilized inverse filter and Q estimated on instantaneous spectra

    OpenAIRE

    Corrales, Álvaro; Cabrera, Francisco; Montes, Luis

    2014-01-01

    Physical phenomena, such as attenuation of high frequency components and velocity dispersion, deteriorate seismic images. To enhance seismic resolution, Q filtering is usually applied, where the accurate estimation of Q is the core of this approach. The Matching Pursuit (MP) approach is an instantaneous spectral analysis method that overcomes windowing problems caused by decomposing a seismic trace, providing a frequency spectrum for each time sample of the trace. By changing variables, the s...

  5. Modeling of process parameters for enhanced production of coenzyme Q10 from Rhodotorula glutinis.

    Science.gov (United States)

    Balakumaran, Palanisamy Athiyaman; Meenakshisundaram, Sankaranarayanan

    2015-01-01

    Coenzyme Q10 (CoQ10) plays an indispensable role in ATP generation through oxidative phosphorylation and helps in scavenging superoxides generated during electron transfer reactions. It finds extensive applications specifically related to oxidative damage and metabolic dysfunctions. This article reports the use of a statistical approach to optimize the concentration of key variables for the enhanced production of CoQ10 by Rhodotorula glutinis in a lab-scale fermenter. The culture conditions that promote optimum growth and CoQ10 production were optimized and the interaction of significant variables para-hydroxybenzoic acid (PHB, 819.34 mg/L) and soybean oil (7.78% [v/v]) was studied using response surface methodology (RSM). CoQ10 production increased considerably from 10 mg/L (in control) to 39.2 mg/L in batch mode with RSM-optimized precursor concentration. In the fed-batch mode, PHB and soybean oil feeding strategy enhanced CoQ10 production to 78.2 mg/L.

  6. Bioavailability enhancement of coenzyme Q10: an extensive review of patents.

    Science.gov (United States)

    Beg, Sarwar; Javed, Shamama; Kohli, Kanchan

    2010-11-01

    Coenzyme Q10 (CoQ10) is a major antioxidant principle found in human body which plays a vital role in maintaining several biochemical pathways of body. It acts as a potential mediator in transferring electrons in oxidoreductive reactions of electron transport chain. Chemically, it is a basic quinone containing moiety having a large and high molecular weight structure. Deficiency of this in body leads to several potential disorders like dysfunctions in cellular energetics, neurological degeneration, higher oxidative stress induced damage, breast cancer etc. The high molecular weight and lipophilicity of CoQ10 makes it poorly water soluble and consequently leads to low systemic availability. Several advancements have been made to enhance the bioavailability of CoQ10 using various approaches like size reduction, solubility enhancement (by solid dispersion, prodrug, complexation, ionization) and use of novel drug carriers such as liposomes, microspheres, nanoparticles, nanoemulsions and self-emulsifying system. The primary objective of the present review is to assemble patents representing the various approaches used for enhancement of CoQ10 bioavailability.

  7. Cardinality enhancement utilizing Sequential Algorithm (SeQ code in OCDMA system

    Directory of Open Access Journals (Sweden)

    Fazlina C. A. S.

    2017-01-01

    Full Text Available Optical Code Division Multiple Access (OCDMA has been important with increasing demand for high capacity and speed for communication in optical networks because of OCDMA technique high efficiency that can be achieved, hence fibre bandwidth is fully used. In this paper we will focus on Sequential Algorithm (SeQ code with AND detection technique using Optisystem design tool. The result revealed SeQ code capable to eliminate Multiple Access Interference (MAI and improve Bit Error Rate (BER, Phase Induced Intensity Noise (PIIN and orthogonally between users in the system. From the results, SeQ shows good performance of BER and capable to accommodate 190 numbers of simultaneous users contrast with existing code. Thus, SeQ code have enhanced the system about 36% and 111% of FCC and DCS code. In addition, SeQ have good BER performance 10-25 at 155 Mbps in comparison with 622 Mbps, 1 Gbps and 2 Gbps bit rate. From the plot graph, 155 Mbps bit rate is suitable enough speed for FTTH and LAN networks. Resolution can be made based on the superior performance of SeQ code. Thus, these codes will give an opportunity in OCDMA system for better quality of service in an optical access network for future generation's usage

  8. Cardinality enhancement utilizing Sequential Algorithm (SeQ) code in OCDMA system

    Science.gov (United States)

    Fazlina, C. A. S.; Rashidi, C. B. M.; Rahman, A. K.; Aljunid, S. A.

    2017-11-01

    Optical Code Division Multiple Access (OCDMA) has been important with increasing demand for high capacity and speed for communication in optical networks because of OCDMA technique high efficiency that can be achieved, hence fibre bandwidth is fully used. In this paper we will focus on Sequential Algorithm (SeQ) code with AND detection technique using Optisystem design tool. The result revealed SeQ code capable to eliminate Multiple Access Interference (MAI) and improve Bit Error Rate (BER), Phase Induced Intensity Noise (PIIN) and orthogonally between users in the system. From the results, SeQ shows good performance of BER and capable to accommodate 190 numbers of simultaneous users contrast with existing code. Thus, SeQ code have enhanced the system about 36% and 111% of FCC and DCS code. In addition, SeQ have good BER performance 10-25 at 155 Mbps in comparison with 622 Mbps, 1 Gbps and 2 Gbps bit rate. From the plot graph, 155 Mbps bit rate is suitable enough speed for FTTH and LAN networks. Resolution can be made based on the superior performance of SeQ code. Thus, these codes will give an opportunity in OCDMA system for better quality of service in an optical access network for future generation's usage

  9. Activation of Gαq Signaling Enhances Memory Consolidation and Slows Cognitive Decline.

    Science.gov (United States)

    Arey, Rachel N; Stein, Geneva M; Kaletsky, Rachel; Kauffman, Amanda; Murphy, Coleen T

    2018-05-02

    Perhaps the most devastating decline with age is the loss of memory. Therefore, identifying mechanisms to restore memory function with age is critical. Using C. elegans associative learning and memory assays, we identified a gain-of-function G αq signaling pathway mutant that forms a long-term (cAMP response element binding protein [CREB]-dependent) memory following one conditioned stimulus-unconditioned stimulus (CS-US) pairing, which usually requires seven CS-US pairings. Increased CREB activity in AIM interneurons reduces the threshold for memory consolidation through transcription of a set of previously identified "long-term memory" genes. Enhanced G αq signaling in the AWC sensory neuron is both necessary and sufficient for improved memory and increased AIM CREB activity, and activation of G αq specifically in aged animals rescues the ability to form memory. Activation of G αq in AWC sensory neurons non-cell autonomously induces consolidation after one CS-US pairing, enabling both cognitive function maintenance with age and restoration of memory function in animals with impaired memory performance without decreased longevity. Copyright © 2018 Elsevier Inc. All rights reserved.

  10. Human COQ9 Rescues a coq9 Yeast Mutant by Enhancing Coenzyme Q Biosynthesis from 4-Hydroxybenzoic Acid and Stabilizing the CoQ-Synthome

    Directory of Open Access Journals (Sweden)

    Cuiwen H. He

    2017-07-01

    Full Text Available Coq9 is required for the stability of a mitochondrial multi-subunit complex, termed the CoQ-synthome, and the deamination step of Q intermediates that derive from para-aminobenzoic acid (pABA in yeast. In human, mutations in the COQ9 gene cause neonatal-onset primary Q10 deficiency. In this study, we determined whether expression of human COQ9 could complement yeast coq9 point or null mutants. We found that expression of human COQ9 rescues the growth of the temperature-sensitive yeast mutant, coq9-ts19, on a non-fermentable carbon source and increases the content of Q6, by enhancing Q biosynthesis from 4-hydroxybenzoic acid (4HB. To study the mechanism for the rescue by human COQ9, we determined the steady-state levels of yeast Coq polypeptides in the mitochondria of the temperature-sensitive yeast coq9 mutant expressing human COQ9. We show that the expression of human COQ9 significantly increased steady-state levels of yeast Coq4, Coq6, Coq7, and Coq9 at permissive temperature. Human COQ9 polypeptide levels persisted at non-permissive temperature. A small amount of the human COQ9 co-purified with tagged Coq6, Coq6-CNAP, indicating that human COQ9 interacts with the yeast Q-biosynthetic complex. These findings suggest that human COQ9 rescues the yeast coq9 temperature-sensitive mutant by stabilizing the CoQ-synthome and increasing Q biosynthesis from 4HB. This finding provides a powerful approach to studying the function of human COQ9 using yeast as a model.

  11. Additive enhancement of wound healing in diabetic mice by low level light and topical CoQ10

    Science.gov (United States)

    Mao, Zhigang; Wu, Jeffrey H.; Dong, Tingting; Wu, Mei X.

    2016-02-01

    Diabetes, a highly prevalent disease that affects 9.3% of Americans, often leads to severe complications and slow wound healing. Preclinical studies have suggested that low level light therapy (LLLT) can accelerate wound healing in diabetic subjects, but significant improvements must be made to overcome the absence of persuasive evidence for its clinical use. We demonstrate here that LLLT can be combined with topical Coenzyme Q10 (CoQ10) to heal wounds in diabetic mice significantly faster than LLLT alone, CoQ10 alone, or controls. LLLT followed by topical CoQ10 enhanced wound healing by 68~103% in diabetic mice in the first week and more than 24% in the second week compared with untreated controls. All wounds were fully healed in two weeks following the dual treatment, in contrast to only 50% wounds or a fewer being fully healed for single or sham treatment. The accelerated healing was corroborated by at least 50% higher hydroxyproline levels, and tripling cell proliferation rates in LLLT and CoQ10 treated wounds over controls. The beneficial effects on wound healing were probably attributed to additive enhancement of ATP production by LLLT and CoQ10 treatment. The combination of LLLT and topical CoQ10 is safe and convenient, and merits further clinical study.

  12. Additive enhancement of wound healing in diabetic mice by low level light and topical CoQ10.

    Science.gov (United States)

    Mao, Zhigang; Wu, Jeffrey H; Dong, Tingting; Wu, Mei X

    2016-02-02

    Diabetes, a highly prevalent disease that affects 9.3% of Americans, often leads to severe complications and slow wound healing. Preclinical studies have suggested that low level light therapy (LLLT) can accelerate wound healing in diabetic subjects, but significant improvements must be made to overcome the absence of persuasive evidence for its clinical use. We demonstrate here that LLLT can be combined with topical Coenzyme Q10 (CoQ10) to heal wounds in diabetic mice significantly faster than LLLT alone, CoQ10 alone, or controls. LLLT followed by topical CoQ10 enhanced wound healing by 68~103% in diabetic mice in the first week and more than 24% in the second week compared with untreated controls. All wounds were fully healed in two weeks following the dual treatment, in contrast to only 50% wounds or a fewer being fully healed for single or sham treatment. The accelerated healing was corroborated by at least 50% higher hydroxyproline levels, and tripling cell proliferation rates in LLLT and CoQ10 treated wounds over controls. The beneficial effects on wound healing were probably attributed to additive enhancement of ATP production by LLLT and CoQ10 treatment. The combination of LLLT and topical CoQ10 is safe and convenient, and merits further clinical study.

  13. Two-Stage Design Method for Enhanced Inductive Energy Transmission with Q-Constrained Planar Square Loops.

    Directory of Open Access Journals (Sweden)

    Akaa Agbaeze Eteng

    Full Text Available Q-factor constraints are usually imposed on conductor loops employed as proximity range High Frequency Radio Frequency Identification (HF-RFID reader antennas to ensure adequate data bandwidth. However, pairing such low Q-factor loops in inductive energy transmission links restricts the link transmission performance. The contribution of this paper is to assess the improvement that is reached with a two-stage design method, concerning the transmission performance of a planar square loop relative to an initial design, without compromise to a Q-factor constraint. The first stage of the synthesis flow is analytical in approach, and determines the number and spacing of turns by which coupling between similar paired square loops can be enhanced with low deviation from the Q-factor limit presented by an initial design. The second stage applies full-wave electromagnetic simulations to determine more appropriate turn spacing and widths to match the Q-factor constraint, and achieve improved coupling relative to the initial design. Evaluating the design method in a test scenario yielded a more than 5% increase in link transmission efficiency, as well as an improvement in the link fractional bandwidth by more than 3%, without violating the loop Q-factor limit. These transmission performance enhancements are indicative of a potential for modifying proximity HF-RFID reader antennas for efficient inductive energy transfer and data telemetry links.

  14. Enhancing the resonance stability of a high-Q micro/nanoresonator by an optical means

    Science.gov (United States)

    Sun, Xuan; Luo, Rui; Zhang, Xi-Cheng; Lin, Qiang

    2016-02-01

    High-quality optical resonators underlie many important applications ranging from optical frequency metrology, precision measurement, nonlinear/quantum photonics, to diverse sensing such as detecting single biomolecule, electromagnetic field, mechanical acceleration/rotation, among many others. All these applications rely essentially on the stability of optical resonances, which, however, is ultimately limited by the fundamental thermal fluctuations of the devices. The resulting thermo-refractive and thermo-elastic noises have been widely accepted for nearly two decades as the fundamental thermodynamic limit of an optical resonator, limiting its resonance uncertainty to a magnitude 10-12 at room temperature. Here we report a novel approach that is able to significantly improve the resonance stability of an optical resonator. We show that, in contrast to the common belief, the fundamental temperature fluctuations of a high-Q micro/nanoresonator can be suppressed remarkably by pure optical means without cooling the device temperature, which we term as temperature squeezing. An optical wave with only a fairly moderate power launched into the device is able to produce strong photothermal backaction that dramatically suppresses the spectral intensity of temperature fluctuations by five orders of magnitudes and squeezes the overall level (root-mean-square value) of temperature fluctuations by two orders of magnitude. The proposed approach is universally applicable to various micro/nanoresonator platforms and the optimal temperature squeezing can be achieved with an optical Q around 106-107 that is readily available in various current devices. The proposed photothermal temperature squeezing is expected to have profound impact on broad applications of high-Q cavities in sensing, metrology, and integrated nonlinear/quantum photonics.

  15. Overexpression of NtPR-Q Up-Regulates Multiple Defense-Related Genes in Nicotiana tabacum and Enhances Plant Resistance to Ralstonia solanacearum

    Directory of Open Access Journals (Sweden)

    Yuanman Tang

    2017-11-01

    Full Text Available Various classes of plant pathogenesis-related proteins have been identified in the past several decades. PR-Q, a member of the PR3 family encoding chitinases, has played an important role in regulating plant resistance and preventing pathogen infection. In this paper, we functionally characterized NtPR-Q in tobacco plants and found that the overexpression of NtPR-Q in tobacco Yunyan87 resulted in higher resistance to Ralstonia solanacearum inoculation. Surprisingly, overexpression of NtPR-Q led to the activation of many defense-related genes, such as salicylic acid (SA-responsive genes NtPR1a/c, NtPR2 and NtCHN50, JA-responsive gene NtPR1b and ET production-associated genes NtACC Oxidase and NtEFE26. Consistent with the role of NtPR-Q in multiple stress responses, NtPR-Q transcripts were induced by the exogenous hormones SA, ethylene and methyl jasmonate, which could enhance the resistance of tobacco to R. solanacearum. Collectively, our results suggested that NtPR-Q overexpression led to the up-regulation of defense-related genes and enhanced plant resistance to R. solanacearum infection.

  16. Enhanced Maternal Origin of the 22q11.2 Deletion in Velocardiofacial and DiGeorge Syndromes

    DEFF Research Database (Denmark)

    Delio, Maria; Guo, Tingwei; McDonald-McGinn, Donna M

    2013-01-01

    Velocardiofacial and DiGeorge syndromes, also known as 22q11.2 deletion syndrome (22q11DS), are congenital-anomaly disorders caused by a de novo hemizygous 22q11.2 deletion mediated by meiotic nonallelic homologous recombination events between low-copy repeats, also known as segmental duplication...

  17. Kazinol Q from Broussonetia kazinoki Enhances Cell Death Induced by Cu(ll through Increased Reactive Oxygen Species

    Directory of Open Access Journals (Sweden)

    Hsue-Yin Hsu

    2011-04-01

    Full Text Available The ability of the flavan kazinol Q (KQ to induce DNA breakage in the presence of Cu(II was examined by agarose gel electrophoresis using supercoiled plasmid DNA. In KQ-mediated DNA breakage reaction, the involvement of reactive oxygen species (ROS, H2O2 and O2 - was established by the inhibition of DNA breakage by catalase and revealed DNA breakage by superoxide dismutase (SOD. The cell viability of gastric carcinoma SCM-1 cells treated with various concentrations of KQ was significantly decreased by cotreatment with Cu(II. Treatment of SCM-1 cells with 300 μM Cu(II enhanced the necrosis induced by 100 μM KQ. Treatment of SCM-1 cells with 100 mM KQ in the presence of 300 mM Cu(II increased the generation of H2O2. Taken together, the above finding suggested that KQ cotreatment with Cu(II produced increased amounts of H2O2, thus enhancing subsequent cell death due to necrosis.

  18. Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers

    DEFF Research Database (Denmark)

    French, Juliet D; Ghoussaini, Maya; Edwards, Stacey L

    2013-01-01

    Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for estrogen-receptor-positive tumors at 11q13. The strongest signal maps to a transcriptional enhancer element in which the G allele of the best candidate causativ...

  19. Possible Heavy Tetraquarks qQ(-q-Q), qq(-Q-Q) and qQ(-Q-Q)%可能的qQ(-q-Q),qq(-Q-Q)和qQ(-Q-Q)重四夸克态

    Institute of Scientific and Technical Information of China (English)

    崔莹; 陈晓林; 邓卫真; 朱世琳

    2007-01-01

    Assuming X(3872) is a qc-q-c tetraquark and using its mass as input, we perform a schematic study of the masses of possible heavy tetraquarks using the color-magnetic interaction with the flavor symmetry breaking corrections.%假设X(3872)是一个qc(-q-c)四夸克态,并用它的质量作为输入,用具有味对称性破坏的色磁相互作用系统研究了可能的重四夸克态的质量谱.

  20. An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression

    Science.gov (United States)

    Wyszynski, Asaf; Hong, Chi-Chen; Lam, Kristin; Michailidou, Kyriaki; Lytle, Christian; Yao, Song; Zhang, Yali; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Hopper, John L.; Southey, Melissa C.; Schmidt, Marjanka K.; Broeks, Annegien; Muir, Kenneth; Lophatananon, Artitaya; Fasching, Peter A.; Beckmann, Matthias W.; Peto, Julian; dos-Santos-Silva, Isabel; Sawyer, Elinor J.; Tomlinson, Ian; Burwinkel, Barbara; Marme, Frederik; Guénel, Pascal; Truong, Thérèse; Bojesen, Stig E.; Nordestgaard, Børge G.; González-Neira, Anna; Benitez, Javier; Neuhausen, Susan L.; Brenner, Hermann; Dieffenbach, Aida Karina; Meindl, Alfons; Schmutzler, Rita K.; Brauch, Hiltrud; Nevanlinna, Heli; Khan, Sofia; Matsuo, Keitaro; Ito, Hidemi; Dörk, Thilo; Bogdanova, Natalia V.; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kosma, Veli-Matti; Wu, Anna H.; Van Den Berg, David; Lambrechts, Diether; Wildiers, Hans; Chang-Claude, Jenny; Rudolph, Anja; Radice, Paolo; Peterlongo, Paolo; Couch, Fergus J.; Olson, Janet E.; Giles, Graham G.; Milne, Roger L.; Haiman, Christopher A.; Henderson, Brian E.; Dumont, Martine; Teo, Soo Hwang; Wong, Tien Y.; Kristensen, Vessela; Zheng, Wei; Long, Jirong; Winqvist, Robert; Pylkäs, Katri; Andrulis, Irene L.; Knight, Julia A.; Devilee, Peter; Seynaeve, Caroline; García-Closas, Montserrat; Figueroa, Jonine; Klevebring, Daniel; Czene, Kamila; Hooning, Maartje J.; van den Ouweland, Ans M.W.; Darabi, Hatef; Shu, Xiao-Ou; Gao, Yu-Tang; Cox, Angela; Blot, William; Signorello, Lisa B.; Shah, Mitul; Kang, Daehee; Choi, Ji-Yeob; Hartman, Mikael; Miao, Hui; Hamann, Ute; Jakubowska, Anna; Lubinski, Jan; Sangrajrang, Suleeporn; McKay, James; Toland, Amanda E.; Yannoukakos, Drakoulis; Shen, Chen-Yang; Wu, Pei-Ei; Swerdlow, Anthony; Orr, Nick; Simard, Jacques; Pharoah, Paul D.P.; Dunning, Alison M.; Chenevix-Trench, Georgia; Hall, Per; Bandera, Elisa; Amos, Chris; Ambrosone, Christine; Easton, Douglas F.; Cole, Michael D.

    2016-01-01

    Breast cancer is the most diagnosed malignancy and the second leading cause of cancer mortality in females. Previous association studies have identified variants on 2q35 associated with the risk of breast cancer. To identify functional susceptibility loci for breast cancer, we interrogated the 2q35 gene desert for chromatin architecture and functional variation correlated with gene expression. We report a novel intergenic breast cancer risk locus containing an enhancer copy number variation (enCNV; deletion) located approximately 400Kb upstream to IGFBP5, which overlaps an intergenic ERα-bound enhancer that loops to the IGFBP5 promoter. The enCNV is correlated with modified ERα binding and monoallelic-repression of IGFBP5 following oestrogen treatment. We investigated the association of enCNV genotype with breast cancer in 1,182 cases and 1,362 controls, and replicate our findings in an independent set of 62,533 cases and 60,966 controls from 41 case control studies and 11 GWAS. We report a dose-dependent inverse association of 2q35 enCNV genotype (percopy OR = 0.68 95%CI 0.55–0.83, P = 0.0002; replication OR = 0.77 95% CI 0.73-0.82, P = 2.1 × 10−19) and identify 13 additional linked variants (r2 > 0.8) in the 20Kb linkage block containing the enCNV (P = 3.2 × 10−15 − 5.6 × 10−17). These associations were independent of previously reported 2q35 variants, rs13387042/rs4442975 and rs16857609, and were stronger for ER-positive than ER-negative disease. Together, these results suggest that 2q35 breast cancer risk loci may be mediating their effect through IGFBP5. PMID:27402876

  1. Overexpression of the mulberry latex gene MaMLX-Q1 enhances defense against Plutella xylostella in Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Liu Yan

    2017-01-01

    Full Text Available Purified mulberry latex chitinase (MLX has a role in defense against some lepidopteran insects. In this study, a full length chitinase gene, MaMLX-Q1, of 1405 bp with a 1140 bp open reading frame, was obtained from mulberry leaves by the degenerate primers and rapid amplification of cDNA ends polymerase chain reaction (RACE-PCR procedure. The gene encoded a mature protein with the predicted molecular mass of 39.38 kDa and an isoelectric point (pI of 6.43; it contained two chitin-binding domains and a hydrolase family 19 chitinase domain. Sequence alignment and phylogenetic analysis grouped it in the class I chitinase protein group. Heterogeneous expression of this MaMLX-Q1 in Arabidopsis showed non-visible alterations in growth phenotype, except for the higher transcriptional expression of MaMLX-Q1 when compared to that of wild-type Arabidopsis. This ectopic MaMLX-Q1 exhibited toxicity to the growth and development of Plutella xylostella larvae, causing significantly lower weight gain and higher mortality. These results indicate an application of MaMLX-Q1 as an insecticide for plant protection.

  2. Q QIAO

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. Q QIAO. Articles written in Bulletin of Materials Science. Volume 39 Issue 2 April 2016 pp 519-523. Effect of temperature on structure and corrosion resistance for electroless NiWP coating · M Q YU Q QIAO F YOU C L LI Y ZHAO Z Z XIAO H L LUO Z F XU KAZUHIRO MATSUGI ...

  3. Functional Variants at the 11q13 Risk Locus for Breast Cancer Regulate Cyclin D1 Expression through Long-Range Enhancers

    Science.gov (United States)

    French, Juliet D.; Ghoussaini, Maya; Edwards, Stacey L.; Meyer, Kerstin B.; Michailidou, Kyriaki; Ahmed, Shahana; Khan, Sofia; Maranian, Mel J.; O’Reilly, Martin; Hillman, Kristine M.; Betts, Joshua A.; Carroll, Thomas; Bailey, Peter J.; Dicks, Ed; Beesley, Jonathan; Tyrer, Jonathan; Maia, Ana-Teresa; Beck, Andrew; Knoblauch, Nicholas W.; Chen, Constance; Kraft, Peter; Barnes, Daniel; González-Neira, Anna; Alonso, M. Rosario; Herrero, Daniel; Tessier, Daniel C.; Vincent, Daniel; Bacot, Francois; Luccarini, Craig; Baynes, Caroline; Conroy, Don; Dennis, Joe; Bolla, Manjeet K.; Wang, Qin; Hopper, John L.; Southey, Melissa C.; Schmidt, Marjanka K.; Broeks, Annegien; Verhoef, Senno; Cornelissen, Sten; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Fasching, Peter A.; Loehberg, Christian R.; Ekici, Arif B.; Beckmann, Matthias W.; Peto, Julian; dos Santos Silva, Isabel; Johnson, Nichola; Aitken, Zoe; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Burwinkel, Barbara; Guénel, Pascal; Truong, Thérèse; Laurent-Puig, Pierre; Menegaux, Florence; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Milne, Roger L.; Zamora, M. Pilar; Arias Perez, Jose Ignacio; Benitez, Javier; Anton-Culver, Hoda; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Meindl, Alfons; Lichtner, Peter; Schmutzler, Rita K.; Engel, Christoph; Brauch, Hiltrud; Hamann, Ute; Justenhoven, Christina; Aaltonen, Kirsimari; Heikkilä, Päivi; Aittomäki, Kristiina; Blomqvist, Carl; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Sueta, Aiko; Bogdanova, Natalia V.; Antonenkova, Natalia N.; Dörk, Thilo; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Wu, Anna H.; Tseng, Chiu-chen; Van Den Berg, David; Stram, Daniel O.; Lambrechts, Diether; Peeters, Stephanie; Smeets, Ann; Floris, Giuseppe; Chang-Claude, Jenny; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Radice, Paolo; Peterlongo, Paolo; Bonanni, Bernardo; Sardella, Domenico; Couch, Fergus J.; Wang, Xianshu; Pankratz, Vernon S.; Lee, Adam; Giles, Graham G.; Severi, Gianluca; Baglietto, Laura; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Simard, Jacques; Goldberg, Mark S.; Labrèche, France; Dumont, Martine; Teo, Soo Hwang; Yip, Cheng Har; Ng, Char-Hong; Vithana, Eranga Nishanthie; Kristensen, Vessela; Zheng, Wei; Deming-Halverson, Sandra; Shrubsole, Martha; Long, Jirong; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Mulligan, Anna Marie; Devilee, Peter; Seynaeve, Caroline; García-Closas, Montserrat; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Czene, Kamila; Klevebring, Daniel; Schoof, Nils; Hooning, Maartje J.; Martens, John W.M.; Collée, J. Margriet; Tilanus-Linthorst, Madeleine; Hall, Per; Li, Jingmei; Liu, Jianjun; Humphreys, Keith; Shu, Xiao-Ou; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Cox, Angela; Balasubramanian, Sabapathy P.; Blot, William; Signorello, Lisa B.; Cai, Qiuyin; Pharoah, Paul D.P.; Healey, Catherine S.; Shah, Mitul; Pooley, Karen A.; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Hartman, Mikael; Miao, Hui; Sng, Jen-Hwei; Sim, Xueling; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Sangrajrang, Suleeporn; Gaborieau, Valerie; McKay, James; Toland, Amanda E.; Ambrosone, Christine B.; Yannoukakos, Drakoulis; Godwin, Andrew K.; Shen, Chen-Yang; Hsiung, Chia-Ni; Wu, Pei-Ei; Chen, Shou-Tung; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Schoemaker, Minouk J.; Ponder, Bruce A.J.; Nevanlinna, Heli; Brown, Melissa A.; Chenevix-Trench, Georgia; Easton, Douglas F.; Dunning, Alison M.

    2013-01-01

    Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for estrogen-receptor-positive tumors at 11q13. The strongest signal maps to a transcriptional enhancer element in which the G allele of the best candidate causative variant rs554219 increases risk of breast cancer, reduces both binding of ELK4 transcription factor and luciferase activity in reporter assays, and may be associated with low cyclin D1 protein levels in tumors. Another candidate variant, rs78540526, lies in the same enhancer element. Risk association signal 2, rs75915166, creates a GATA3 binding site within a silencer element. Chromatin conformation studies demonstrate that these enhancer and silencer elements interact with each other and with their likely target gene, CCND1. PMID:23540573

  4. Q-factor enhancement for self-actuated self-sensing piezoelectric MEMS resonators applying a lock-in driven feedback loop

    International Nuclear Information System (INIS)

    Kucera, M; Bittner, A; Schmid, U; Manzaneque, T; Sánchez-Rojas, J L

    2013-01-01

    This paper presents a robust Q-control approach based on an all-electrical feedback loop enhancing the quality factor of a resonant microstructure by using the self-sensing capability of a piezoelectric thin film actuator made of aluminium nitride. A lock-in amplifier is used to extract the feedback signal which is proportional to the piezoelectric current. The measured real part is used to replace the originally low-quality and noisy feedback signal to modulate the driving voltage of the piezoelectric thin-film actuator. Since the lock-in amplifier reduces the noise in the feedback signal substantially, the proposed enhancement loop avoids the disadvantage of a constant signal-to-noise ratio, which an analogue feedback circuit usually suffers from. The quality factor was increased from the intrinsic value of 1766 to a maximum of 34 840 in air. These promising results facilitate precise measurements for self-actuated and self-sensing MEMS cantilevers even when operated in static viscous media. (paper)

  5. Observation of enhanced zero-degree binary encounter electron production with decreasing charge-state q in 30 MeV Oq+ + O2 collisions

    International Nuclear Information System (INIS)

    Zouros, T.J.M.; Wong, K.L.; Hidmi, H.I.

    1993-01-01

    We have measured binary encounter electron production in collisions of 30 MeV O q+ projectiles (q=4-8) and O 2 targets. Measured double differential BEe cross-sections are found to increase with decreasing charge-state q, in agreement with similar previously reported zero-degree investigations for H 2 and He targets. However, measurements for the same system but at 25 degrees shows the opposite trend, that BEe cross sections decrease slightly with decreasing charge state

  6. An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression

    DEFF Research Database (Denmark)

    Wyszynski, Asaf; Hong, Chi-chen; Lam, Kristin

    2016-01-01

    Breast cancer is the most diagnosed malignancy and the second leading cause of cancer mortality in females. Previous association studies have identified variants on 2q35 associated with the risk of breast cancer. To identify functional susceptibility loci for breast cancer, we interrogated the 2q35...... suggest that 2q35 breast cancer risk loci may be mediating their effect through IGFBP5....

  7. The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd.

    NARCIS (Netherlands)

    Lu, P.; Asseri, A.H.O.; Kremer, Martijn; Maaskant, Janneke; Ummels, Roy; Lill, H.; Bald, D.

    2018-01-01

    Mycobacterial energy metabolism currently attracts strong attention as new target space for development of anti-tuberculosis drugs. The imidazopyridine Q203 targets the cytochrome bcc complex of the respiratory chain, a key component in energy metabolism. Q203 blocks growth of Mycobacterium

  8. The Possible Heavy Tetraquarks $qQ\\bar q \\bar Q$, $qq\\bar Q \\bar Q$ and $qQ\\bar Q \\bar Q$

    OpenAIRE

    Cui, Ying; Chen, Xiao-Lin; Deng, Wei-Zhen; Zhu, Shi-Lin

    2006-01-01

    Assuming X(3872) is a $qc \\bar q \\bar c$ tetraquark and using its mass as input, we perform a schematic study of the masses of possible heavy tetraquarks using the color-magnetic interaction with the flavor symmetry breaking corrections.

  9. Inhibition of Mef2a Enhances Neovascularization via Post-transcriptional Regulation of 14q32 MicroRNAs miR-329 and miR-494

    Directory of Open Access Journals (Sweden)

    Sabine M.J. Welten

    2017-06-01

    Full Text Available Improving the efficacy of neovascularization is a promising strategy to restore perfusion of ischemic tissues in patients with peripheral arterial disease. The 14q32 microRNA cluster is highly involved in neovascularization. The Mef2a transcription factor has been shown to induce transcription of the microRNAs within this cluster. We inhibited expression of Mef2a using gene-silencing oligonucleotides (GSOs in an in vivo hind limb ischemia model. Treatment with GSO-Mef2a clearly improved blood flow recovery within 3 days (44% recovery versus 25% recovery in control and persisted until 14 days after ischemia induction (80% recovery versus 60% recovery in control. Animals treated with GSO-Mef2a showed increased arteriogenesis and angiogenesis in the relevant muscle tissues. Inhibition of Mef2a decreased expression of 14q32 microRNAs miR-329 (p = 0.026 and miR-494 (trend, p = 0.06, but not of other 14q32 microRNAs, nor of 14q32 microRNA precursors. Because Mef2a did not influence 14q32 microRNA transcription, we hypothesized it functions as an RNA-binding protein that influences processing of 14q32 microRNA miR-329 and miR-494. Mef2A immunoprecipitation followed by RNA isolation and rt/qPCR confirmed direct binding of MEF2A to pri-miR-494, supporting this hypothesis. Our study demonstrates a novel function for Mef2a in post-ischemic neovascularization via post-transcriptional regulation of 14q32 microRNAs miR-329 and miR-494.

  10. Open-flavor charm and bottom s q q ¯ Q ¯ and q q q ¯ Q ¯ tetraquark states

    Science.gov (United States)

    Chen, Wei; Chen, Hua-Xing; Liu, Xiang; Steele, T. G.; Zhu, Shi-Lin

    2017-06-01

    We provide comprehensive investigations for the mass spectrum of exotic open-flavor charmed/bottom s q q ¯ c ¯ , q q q ¯ c ¯ , s q q ¯ b ¯ , q q q ¯ b ¯ tetraquark states with various spin-parity assignments JP=0+,1+,2+ and 0- , 1- in the framework of QCD sum rules. In the diquark configuration, we construct the diquark-antidiquark interpolating tetraquark currents using the color-antisymmetric scalar and axial-vector diquark fields. The stable mass sum rules are established in reasonable parameter working ranges, which are used to give reliable mass predictions for these tetraquark states. We obtain the mass spectra for the open-flavor charmed/bottom s q q ¯c ¯, q q q ¯c ¯, s q q ¯b ¯, q q q ¯b ¯ tetraquark states with various spin-parity quantum numbers. In addition, we suggest searching for exotic doubly-charged tetraquarks, such as [s d ][u ¯ c ¯ ]→Ds(*)-π- in future experiments at facilities such as BESIII, BelleII, PANDA, LHCb, and CMS, etc.

  11. Skew cyclic codes over F_q+uF_q+vF_q+uvF_q

    Directory of Open Access Journals (Sweden)

    Ting Yao

    2015-09-01

    Full Text Available In this paper, we study skew cyclic codes over the ring $R=F_q+uF_q+vF_q+uvF_q$, where $u^{2}=u,v^{2}=v,uv=vu$, $q=p^{m}$ and $p$ is an odd prime. We investigate the structural properties of skew cyclic codes over $R$ through a decomposition theorem. Furthermore, we give a formula for the number of skew cyclic codes of length $n$ over $R.$

  12. RECENT ADVANCES IN THE 5Q- SYNDROME

    Directory of Open Access Journals (Sweden)

    Andrea Pellagatti

    2015-05-01

    Full Text Available The 5q- syndrome is the most distinct of the myelodysplastic syndromes (MDS and patients with this disorder have a deletion of chromosome 5q [del(5q] as the sole karyotypic abnormality. Several genes mapping to the commonly deleted region of the 5q- syndrome have been implicated in disease pathogenesis in recent years. Haploinsufficiency of the ribosomal gene RPS14 has been shown to cause the erythroid defect in the 5q- syndrome. Loss of the microRNA genes miR-145 and miR-146a has been associated with the thrombocytosis observed in 5q- syndrome patients. Haploinsufficiency of CSNK1A1 leads to hematopoietic stem cell expansion in mice and may play a role in the initial clonal expansion in patients with 5q- syndrome. Moreover, a subset of patients harbor mutation of the remaining CSNK1A1 allele. Mouse models of the 5q- syndrome, which recapitulate the key features of the human disease, indicate that a p53-dependent mechanism underlies the pathophysiology of this disorder. Importantly, activation of p53 has been demonstrated in the human 5q- syndrome. Recurrent TP53 mutations have been associated with an increased risk of disease evolution and with decreased response to the drug lenalidomide in del(5q MDS patients. Potential new therapeutic agents for del(5q MDS include the translation enhancer L-leucine.

  13. Enhanced antitumor efficacy and counterfeited cardiotoxicity of combinatorial oral therapy using Doxorubicin- and Coenzyme Q10-liquid crystalline nanoparticles in comparison with intravenous Adriamycin

    DEFF Research Database (Denmark)

    Swarnakar, Nitin K; Thanki, Kaushik; Jain, Sanyog

    2014-01-01

    and strong synergism for combination at 1:10 dose ratio owing to higher cellular uptake, nuclear colocalization, higher apoptotic index and 8-OHdG levels. The prophylactic antitumor efficacy of the CoQ10-LCNPs was also established using tumor induction and progression studies. Finally, therapeutic antitumor......, with Dox-induced-cardiotoxicity was completely counterfeited in combination. In nutshell, LCNPs pose great potential in improving the therapeutic efficacy of drugs by oral route of administration. FROM THE CLINICAL EDITOR: This study describes the use of liquid crystalline nanoparticles containing coenzyme...

  14. C anti c q anti q states

    Energy Technology Data Exchange (ETDEWEB)

    Chao, K T [Oxford Univ. (UK). Dept. of Theoretical Physics; Science Research Council, Chilton (UK). Rutherford and Appleton Labs.)

    1980-07-01

    Taking account of the colour magnetic and electric forces, we discuss the spectroscopy of various types of c anti c q anti q states. Their decay, hadronic production, production in e/sup +/e/sup -/ annihilation as well as photoproduction are also studied.

  15. Enhanced mechanical properties of an Al–Si–Cu–Mg alloy at 300 °C: Effects of Mg and the Q-precipitate phase

    International Nuclear Information System (INIS)

    Farkoosh, A.R.; Pekguleryuz, M.

    2015-01-01

    Strategies to improve the strength of Al–Si alloys at elevated temperatures can follow two routes: (i) improving the age-hardening behavior and/or (ii) producing effective dispersoid strengthening. In this study, the influence of Mg (in the range of 0.3–0.7 wt%) on the precipitation characteristics and mechanical properties of the Al–7Si–0.5Cu–(Mg) alloy was investigated. Thermodynamic calculations were performed via the CALPHAD method which showed that Q-Al 5 Mg 8 Cu 2 Si 6 is the main thermodynamically stable precipitate at 300 °C. The calculations were validated by transmission electron microscopy and differential scanning calorimetry analyses. Increasing the Mg level from 0.3 wt% to the maximum solubility limit of ∼0.5 wt% increased the amount of the Q-Al 5 Mg 8 Cu 2 Si 6 precipitates at 300 °C by ∼60 wt% and significantly improved the tensile strength and creep resistance at the expense of some ductility. Mg in excess of the solubility limit was seen to remain within the microstructure in the form of the large π-Al 8 FeMg 3 Si 6 and β-Mg 2 Si intermetallics after solution treatment at 530 °C. Cracking of the brittle π-Al 8 FeMg 3 Si 6 intermetallics during deformation was accounted for the decreased ductility of the alloys at high Mg levels. It is concluded that the Mg level can be increased to 0.5 wt% in the A–7Si–0.5Cu alloys to improve strength. However, for elevated temperature applications in which both strength and ductility are required (e.g. Diesel engine), modification of the π-Al 8 FeMg 3 Si 6 intermetallics would be required to improve the ductility of the alloys with high Mg contents

  16. Q fever in Greenland

    DEFF Research Database (Denmark)

    Koch, Anders; Svendsen, Claus Bo; Christensen, Jens Jorgen

    2010-01-01

    We report a patient with Q fever endocarditis in a settlement in eastern Greenland (Isortoq, Ammassalik area). Likely animal sources include sled dogs and seals. Q fever may be underdiagnosed in Arctic areas but may also represent an emerging infection.......We report a patient with Q fever endocarditis in a settlement in eastern Greenland (Isortoq, Ammassalik area). Likely animal sources include sled dogs and seals. Q fever may be underdiagnosed in Arctic areas but may also represent an emerging infection....

  17. Enhanced mechanical properties of an Al–Si–Cu–Mg alloy at 300 °C: Effects of Mg and the Q-precipitate phase

    Energy Technology Data Exchange (ETDEWEB)

    Farkoosh, A.R., E-mail: amir.rezaeifarkoosh@mail.mcgill.ca; Pekguleryuz, M., E-mail: mihriban.pekguleryuz@mcgill.ca

    2015-01-05

    Strategies to improve the strength of Al–Si alloys at elevated temperatures can follow two routes: (i) improving the age-hardening behavior and/or (ii) producing effective dispersoid strengthening. In this study, the influence of Mg (in the range of 0.3–0.7 wt%) on the precipitation characteristics and mechanical properties of the Al–7Si–0.5Cu–(Mg) alloy was investigated. Thermodynamic calculations were performed via the CALPHAD method which showed that Q-Al{sub 5}Mg{sub 8}Cu{sub 2}Si{sub 6} is the main thermodynamically stable precipitate at 300 °C. The calculations were validated by transmission electron microscopy and differential scanning calorimetry analyses. Increasing the Mg level from 0.3 wt% to the maximum solubility limit of ∼0.5 wt% increased the amount of the Q-Al{sub 5}Mg{sub 8}Cu{sub 2}Si{sub 6} precipitates at 300 °C by ∼60 wt% and significantly improved the tensile strength and creep resistance at the expense of some ductility. Mg in excess of the solubility limit was seen to remain within the microstructure in the form of the large π-Al{sub 8}FeMg{sub 3}Si{sub 6} and β-Mg{sub 2}Si intermetallics after solution treatment at 530 °C. Cracking of the brittle π-Al{sub 8}FeMg{sub 3}Si{sub 6} intermetallics during deformation was accounted for the decreased ductility of the alloys at high Mg levels. It is concluded that the Mg level can be increased to 0.5 wt% in the A–7Si–0.5Cu alloys to improve strength. However, for elevated temperature applications in which both strength and ductility are required (e.g. Diesel engine), modification of the π-Al{sub 8}FeMg{sub 3}Si{sub 6} intermetallics would be required to improve the ductility of the alloys with high Mg contents.

  18. Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus.

    Directory of Open Access Journals (Sweden)

    Clint L Miller

    Full Text Available Coronary heart disease (CHD is the leading cause of mortality in both developed and developing countries worldwide. Genome-wide association studies (GWAS have now identified 46 independent susceptibility loci for CHD, however, the biological and disease-relevant mechanisms for these associations remain elusive. The large-scale meta-analysis of GWAS recently identified in Caucasians a CHD-associated locus at chromosome 6q23.2, a region containing the transcription factor TCF21 gene. TCF21 (Capsulin/Pod1/Epicardin is a member of the basic-helix-loop-helix (bHLH transcription factor family, and regulates cell fate decisions and differentiation in the developing coronary vasculature. Herein, we characterize a cis-regulatory mechanism by which the lead polymorphism rs12190287 disrupts an atypical activator protein 1 (AP-1 element, as demonstrated by allele-specific transcriptional regulation, transcription factor binding, and chromatin organization, leading to altered TCF21 expression. Further, this element is shown to mediate signaling through platelet-derived growth factor receptor beta (PDGFR-β and Wilms tumor 1 (WT1 pathways. A second disease allele identified in East Asians also appears to disrupt an AP-1-like element. Thus, both disease-related growth factor and embryonic signaling pathways may regulate CHD risk through two independent alleles at TCF21.

  19. RecQ Helicases

    DEFF Research Database (Denmark)

    Larsen, Nicolai Balle; Hickson, Ian D

    2013-01-01

    The RecQ family of DNA helicases is highly conserved throughout -evolution, and is important for the maintenance of genome stability. In humans, five RecQ family members have been identified: BLM, WRN, RECQ4, RECQ1 and RECQ5. Defects in three of these give rise to Bloom's syndrome (BLM), Werner...

  20. Q-instantons

    NARCIS (Netherlands)

    Bergshoeff, E. A.; Hartong, J.; Ploegh, A.; Sorokin, D.

    We construct the half-supersymmetric instanton solutions that are electric-magnetically dual to the recently discussed half-supersymmetric Q7-branes. We call these instantons "Q-instantons". Whereas the D-instanton is most conveniently described using the RR axion chi and the dilaton phi, the

  1. Partial deletion 11q

    DEFF Research Database (Denmark)

    Hertz, Jens Michael; Tommerup, N; Sørensen, F B

    1995-01-01

    We describe the cytogenetic findings and the dysmorphic features in a stillborn girl with a large de novo terminal deletion of the long arm of chromosome 11. The karyotype was 46,XX,del(11)(q21qter). By reviewing previous reports of deletion 11q, we found that cleft lip and palate are most...

  2. Compact Q-balls

    Energy Technology Data Exchange (ETDEWEB)

    Bazeia, D., E-mail: bazeia@fisica.ufpb.br [Departamento de Física, Universidade Federal da Paraíba, 58051-970 João Pessoa, PB (Brazil); Losano, L.; Marques, M.A. [Departamento de Física, Universidade Federal da Paraíba, 58051-970 João Pessoa, PB (Brazil); Menezes, R. [Departamento de Ciências Exatas, Universidade Federal da Paraíba, 58297-000 Rio Tinto, PB (Brazil); Departamento de Física, Universidade Federal de Campina Grande, 58109-970 Campina Grande, PB (Brazil); Rocha, R. da [Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, 09210-580 Santo André (Brazil)

    2016-07-10

    In this work we deal with non-topological solutions of the Q-ball type in two space–time dimensions, in models described by a single complex scalar field that engenders global symmetry. The main novelty is the presence of stable Q-balls solutions that live in a compact interval of the real line and appear from a family of models controlled by two distinct parameters. We find analytical solutions and study their charge and energy, and show how to control the parameters to make the Q-balls classically and quantum mechanically stable.

  3. FEMA Q3 Floodways

    Data.gov (United States)

    Minnesota Department of Natural Resources — The Q3 Flood Data are derived from the Flood Insurance Rate Maps (FIRMs) published by the Federal Emergency Management Agency (FEMA). The file is georeferenced to...

  4. The Spirituality of Q

    African Journals Online (AJOL)

    2015-07-01

    Jul 1, 2015 ... deeper communication with the divine, or stem from contemplative reflection upon one's ... In the discourse surrounding the study of religion, 'spirituality' has ..... but as an early strand of Jesus tradition, the Q source provides.

  5. X Q TANG

    Indian Academy of Sciences (India)

    Home; Journals; Bulletin of Materials Science. X Q TANG. Articles written in Bulletin of Materials Science. Volume 41 Issue 2 April 2018 pp 51. Effect of oxygen vacancies on Li-storage of anatase TiO 2 (001) facets: a first principles study · H CHEN Y H DING X Q TANG W ZHANG J R YIN P ZHANG Y JIANG · More Details ...

  6. Structural and electronic properties of Cu2Q and CuQ (Q = O, S, Se, and Te) studied by first-principles calculations

    Science.gov (United States)

    Zhao, Ting; Wang, Yu-An; Zhao, Zong-Yan; Liu, Qiang; Liu, Qing-Ju

    2018-01-01

    In order to explore the similarity, difference, and tendency of binary copper-based chalcogenides, the crystal structure, electronic structure, and optical properties of eight compounds of Cu2Q and CuQ (Q = O, S, Se, and Te) have been calculated by density functional theory with HSE06 method. According to the calculated results, the electronic structure and optical properties of Cu2Q and CuQ present certain similarities and tendencies, with the increase of atomic number of Q elements: the interactions between Cu-Q, Cu-Cu, and Q-Q are gradually enhancing; the value of band gap is gradually decreasing, due to the down-shifting of Cu-4p states; the covalent feature of Cu atoms is gradually strengthening, while their ionic feature is gradually weakening; the absorption coefficient in the visible-light region is also increasing. On the other hand, some differences can be found, owing to the different crystal structure and component, for example: CuO presents the characteristics of multi-band gap, which is very favorable to absorb infrared-light; the electron transfer in CuQ is stronger than that in Cu2Q; the absorption peaks and intensity are very strong in the ultraviolet-light region and infrared-light region. The findings in the present work will help to understand the underlying physical mechanism of binary copper-based chalcogenides, and available to design novel copper-based chalcogenides photo-electronics materials and devices.

  7. Symmetric q-Bessel functions

    Directory of Open Access Journals (Sweden)

    Giuseppe Dattoli

    1996-05-01

    Full Text Available q analog of bessel functions, symmetric under the interchange of q and q^ −1 are introduced. The definition is based on the generating function realized as product of symmetric q-exponential functions with appropriate arguments. Symmetric q-Bessel function are shown to satisfy various identities as well as second-order q-differential equations, which in the limit q → 1 reproduce those obeyed by the usual cylindrical Bessel functions. A brief discussion on the possible algebraic setting for symmetric q-Bessel functions is also provided.

  8. q-deformed Poincare algebra

    International Nuclear Information System (INIS)

    Ogievetsky, O.; Schmidke, W.B.; Wess, J.; Muenchen Univ.; Zumino, B.; Lawrence Berkeley Lab., CA

    1992-01-01

    The q-differential calculus for the q-Minkowski space is developed. The algebra of the q-derivatives with the q-Lorentz generators is found giving the q-deformation of the Poincare algebra. The reality structure of the q-Poincare algebra is given. The reality structure of the q-differentials is also found. The real Laplaacian is constructed. Finally the comultiplication, counit and antipode for the q-Poincare algebra are obtained making it a Hopf algebra. (orig.)

  9. q-bosons and the q-analogue quantized field

    International Nuclear Information System (INIS)

    Nelson, C.A.

    1994-01-01

    The q-analogue coherent states |z > q are used to identify physical signatures for the presence of a q-analogue quantized radiation field in the | > q classical limit where |z| is large. In this quantum-optics-like limit, the fractional uncertainties of most physical quantities (momentum, position, amplitude, phase) which characterize the quantum field are O(1). They only vanish as O(1/|z|) when q = 1. However, for the number operator, N, and the N-Hamiltonian for a free q-boson gas, H N = ℎω(N + 1/2), the fractional uncertainties do still approach zero. A signature for q-boson counting statistics is that (ΔN) 2 / → 0 as |z| → ∞. Except for its O(1) fractional uncertainty, the q-generalization of the Hermitian phase operator of Pegg and Barnett, φ q , still exhibits normal classical behavior. The standard number-phase uncertainty-relation, ΔN Δφ q = 1/2, and the approximate commutation relation, [N,φ q ] = i, still hold for the single-mode q-analogue quantized field. So, N and φ q are almost canonically conjugate operators in the |z > q classical limit. The |z > q CS's minimize this uncertainty relation for moderate |z| 2

  10. Enhanced

    Directory of Open Access Journals (Sweden)

    Martin I. Bayala

    2014-06-01

    Full Text Available Land Surface Temperature (LST is a key parameter in the energy balance model. However, the spatial resolution of the retrieved LST from sensors with high temporal resolution is not accurate enough to be used in local-scale studies. To explore the LST–Normalised Difference Vegetation Index relationship potential and obtain thermal images with high spatial resolution, six enhanced image sharpening techniques were assessed: the disaggregation procedure for radiometric surface temperatures (TsHARP, the Dry Edge Quadratic Function, the Difference of Edges (Ts∗DL and three models supported by the relationship of surface temperature and water stress of vegetation (Normalised Difference Water Index, Normalised Difference Infrared Index and Soil wetness index. Energy Balance Station data and in situ measurements were used to validate the enhanced LST images over a mixed agricultural landscape in the sub-humid Pampean Region of Argentina (PRA, during 2006–2010. Landsat Thematic Mapper (TM and Moderate Resolution Imaging Spectroradiometer (EOS-MODIS thermal datasets were assessed for different spatial resolutions (e.g., 960, 720 and 240 m and the performances were compared with global and local TsHARP procedures. Results suggest that the Ts∗DL technique is the most adequate for simulating LST to high spatial resolution over the heterogeneous landscape of a sub-humid region, showing an average root mean square error of less than 1 K.

  11. Introduction to Q

    International Nuclear Information System (INIS)

    Kellogg, M.; Minor, M.M.; Shlaer, S.; Spencer, N.; Thomas, R.F. Jr.; van der Beken, H.

    1978-06-01

    This manual presents an overview of the Q data-acquisition system. Its purposes are to assist an experimenter in determining whether the system is suited to his needs and to provide an introduction to the more detailed manuals. This system employs a powerful technique for dealing with multiprocessor systems by generating code and communication protocol for two processors from a single source program in a high-level language. Some details of experimental event buffering and distribution are discussed

  12. Tsallis’ quantum q-fields

    Science.gov (United States)

    Plastino, A.; Rocca, M. C.

    2018-05-01

    We generalize several well known quantum equations to a Tsallis’ q-scenario, and provide a quantum version of some classical fields associated with them in the recent literature. We refer to the q-Schródinger, q-Klein-Gordon, q-Dirac, and q-Proca equations advanced in, respectively, Phys. Rev. Lett. 106, 140601 (2011), EPL 118, 61004 (2017) and references therein. We also introduce here equations corresponding to q-Yang-Mills fields, both in the Abelian and non-Abelian instances. We show how to define the q-quantum field theories corresponding to the above equations, introduce the pertinent actions, and obtain equations of motion via the minimum action principle. These q-fields are meaningful at very high energies (TeV scale) for q = 1.15, high energies (GeV scale) for q = 1.001, and low energies (MeV scale) for q = 1.000001 [Nucl. Phys. A 955 (2016) 16 and references therein]. (See the ALICE experiment at the LHC). Surprisingly enough, these q-fields are simultaneously q-exponential functions of the usual linear fields’ logarithms.

  13. q-Deformed Kink solutions

    International Nuclear Information System (INIS)

    Lima, A.F. de

    2003-01-01

    The q-deformed kink of the λφ 4 -model is obtained via the normalisable ground state eigenfunction of a fluctuation operator associated with the q-deformed hyperbolic functions. The kink mass, the bosonic zero-mode and the q-deformed potential in 1+1 dimensions are found. (author)

  14. q-Bernoulli numbers and q-Bernoulli polynomials revisited

    Directory of Open Access Journals (Sweden)

    Kim Taekyun

    2011-01-01

    Full Text Available Abstract This paper performs a further investigation on the q-Bernoulli numbers and q-Bernoulli polynomials given by Acikgöz et al. (Adv Differ Equ, Article ID 951764, 9, 2010, some incorrect properties are revised. It is point out that the generating function for the q-Bernoulli numbers and polynomials is unreasonable. By using the theorem of Kim (Kyushu J Math 48, 73-86, 1994 (see Equation 9, some new generating functions for the q-Bernoulli numbers and polynomials are shown. Mathematics Subject Classification (2000 11B68, 11S40, 11S80

  15. q-deformed Brownian motion

    CERN Document Server

    Man'ko, V I

    1993-01-01

    Brownian motion may be embedded in the Fock space of bosonic free field in one dimension.Extending this correspondence to a family of creation and annihilation operators satisfying a q-deformed algebra, the notion of q-deformation is carried from the algebra to the domain of stochastic processes.The properties of q-deformed Brownian motion, in particular its non-Gaussian nature and cumulant structure,are established.

  16. $q$-norms are really norms

    OpenAIRE

    Belbachir, H.; Mirzavaziri, M.; Moslehian, M. S.

    2005-01-01

    Replacing the triangle inequality, in the definition of a norm, by $|x + y| ^{q}\\leq 2^{q-1}(|x| ^{q} + |y| ^{q}) $, we introduce the notion of a q-norm. We establish that every q-norm is a norm in the usual sense, and that the converse is true as well.

  17. q-deformed Minkowski space

    International Nuclear Information System (INIS)

    Ogievetsky, O.; Pillin, M.; Schmidke, W.B.; Wess, J.; Zumino, B.

    1993-01-01

    In this lecture I discuss the algebraic structure of a q-deformed four-vector space. It serves as a good example of quantizing Minkowski space. To give a physical interpretation of such a quantized Minkowski space we construct the Hilbert space representation and find that the relevant time and space operators have a discrete spectrum. Thus the q-deformed Minkowski space has a lattice structure. Nevertheless this lattice structure is compatible with the operation of q-deformed Lorentz transformations. The generators of the q-deformed Lorentz group can be represented as linear operators in the same Hilbert space. (orig.)

  18. Q-bank phytoplasma database

    DEFF Research Database (Denmark)

    Contaldo, Nicoletta; Bertaccini, Assunta; Nicolaisen, Mogens

    2014-01-01

    The setting of the Q-Bank database free available on line for quarantine phytoplasma and also for general phytoplasma identification is described. The tool was developed in the frame of the EU-FP7 project Qbol and is linked with a new project Q-collect in order to made widely available the identi......The setting of the Q-Bank database free available on line for quarantine phytoplasma and also for general phytoplasma identification is described. The tool was developed in the frame of the EU-FP7 project Qbol and is linked with a new project Q-collect in order to made widely available...

  19. Q2/Q3 2016 Solar Industry Update

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, David; Boff, Daniel; Margolis, Robert

    2016-10-11

    This technical presentation provides an update on the major trends that occurred in the solar industry in the Q2 and Q3 of 2016. Major topics of focus include global and U.S. supply and demand, module and system price, investment trends and business models, and updates on U.S. government programs supporting the solar industry.

  20. Q2/Q3 2017 Solar Industry Update

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, David J. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hoskins, Jack [Dept. of Energy (DOE), Washington DC (United States); Margolis, Robert M. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-10-24

    This technical presentation provides an update on the major trends that occurred in the solar industry in Q2 and Q3 of 2017. Major topics of focus include global and U.S. supply and demand, module and system price, investment trends and business models, and updates on U.S. government programs supporting the solar industry.

  1. Q2 anti Q2 states with relatively narrow widths

    International Nuclear Information System (INIS)

    Ono, Seiji.

    1978-09-01

    Using the mass formulas which correctly predict the mass of mesons and baryons the mass of diquark states is computed. From this mass spectrum the existance of the observed narrow baryonia and wide baryonia can be naturally understood. Other relatively narrow Q 2 anti Q 2 states are predicted to exist. (orig.) [de

  2. Q3/Q4 2016 Solar Industry Update

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, David; Boff, Daniel; Margolis, Robert

    2016-12-21

    This technical presentation provides an update on the major trends that occurred in the solar industry in the Q3 and Q4 of 2016. Major topics of focus include global and U.S. supply and demand, module and system price, investment trends and business models, and updates on U.S. government programs supporting the solar industry.

  3. Q4 2017/Q1 2018 Solar Industry Update

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, David J [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Margolis, Robert M [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Hoskins, Jack [U.S. Department of Energy

    2018-05-16

    This technical presentation provides an update on the major trends that occurred in the solar industry in Q4 2017 and Q1 2018. Major topics of focus include global and U.S. supply and demand, module and system price, investment trends and business models, and updates on U.S. government programs supporting the solar industry.

  4. Q3/Q4 2017 Solar Industry Update

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, David J. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hoskins, Jack [Dept. of Energy (DOE), Washington DC (United States); Margolis, Robert M. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2018-02-15

    This technical presentation provides an update on the major trends that occurred in the solar industry in the Q3 and Q4 of 2017. Major topics of focus include global and U.S. supply and demand, module and system price, investment trends and business models, and updates on U.S. government programs supporting the solar industry.

  5. q-Space Upsampling Using x-q Space Regularization.

    Science.gov (United States)

    Chen, Geng; Dong, Bin; Zhang, Yong; Shen, Dinggang; Yap, Pew-Thian

    2017-09-01

    Acquisition time in diffusion MRI increases with the number of diffusion-weighted images that need to be acquired. Particularly in clinical settings, scan time is limited and only a sparse coverage of the vast q -space is possible. In this paper, we show how non-local self-similar information in the x - q space of diffusion MRI data can be harnessed for q -space upsampling. More specifically, we establish the relationships between signal measurements in x - q space using a patch matching mechanism that caters to unstructured data. We then encode these relationships in a graph and use it to regularize an inverse problem associated with recovering a high q -space resolution dataset from its low-resolution counterpart. Experimental results indicate that the high-resolution datasets reconstructed using the proposed method exhibit greater quality, both quantitatively and qualitatively, than those obtained using conventional methods, such as interpolation using spherical radial basis functions (SRBFs).

  6. Low q operations in Alcator

    International Nuclear Information System (INIS)

    Overskei, D.O.; Gondhalekar, A.; Hutchinson, I.; Pappas, D.; Parker, R.; Rice, J.; Scaturro, L.; Wolfe, S.

    1979-01-01

    The Alcator Tokamak has successfully achieved stable and routine operation in the low q[q(a) <= 2.6] high density regime. Significant increases in the total β are observed with no degradation in the energy confinement times. Strong MHD activity is suppressed by the programmed increase of the plasma current. (Auth.)

  7. Q Fever: Statistics and Epidemiology

    Science.gov (United States)

    ... Q Fever in the United States Hospitalization Rates Geography Seasonal trends People at Risk Q fever was first recognized as a human disease in Australia in 1935 and in the United States in the early 1940s. The “Q” stands for “query” and was applied at a time when the cause was unknown. ...

  8. Q-profiles in JET

    International Nuclear Information System (INIS)

    Gill, R.D.; Edwards, A.W.; Keegan, B.; Lazzaro, E.; O'Rourke, J.; Weller, A.; Zasche, D.

    1989-01-01

    Tokamak q-profiles play a central role in the determination of plasma stability and q(r) towards the plasma centre is particularly important for the sawtooth instability. On JET, q(r) has been determined from magnetic measurements and Faraday rotation. Further information about the position of the q=1 surface has been found from the sawtooth inversion radius, the position of the snake and the resonance effect observed on visible light and X-ray emission during pellet injection. In addition the shear at the q=1 surface has been measured from pellet ablation. This result is supported by the movement of the snake caused by a sawtooth crash. A summary of these data will be made after presenting the new results from pellet ablation. (author) 5 refs., 8 figs

  9. Fiebre "Q" en Uruguay

    Directory of Open Access Journals (Sweden)

    R. E. Somma Moreira

    1987-06-01

    Full Text Available Los autores hacen una revisión de la problemática referida a la fiebre Q, tanto desde el punto de vista clínico como epidemiológico. El primer caso nacional se comunicó en el año 1956, en un adulto, obrero de frigorífico. En 1966 se comunica el primer caso en un niño. A partir de esa fecha se realizan varias encuestas serológicas en humanos y en animales. En seres humanos los hallazgos varían entre 4.2% y 5.5% según el año estudiado. En animales se hallaron valores que oscilaron entre 0.9% (animal para abasto y 30% (animal tipo industria para bovinos. En ovinos, en el único estudio se halló un 10.3% de positivos. En equinos los valores de positividad variaron de 5.5% a 21.7%. En suinos se refiere un porcentaje de positividad del 21.2% en la primera encuesta, sendo en la más reciente del 0.0%. En aves y cobayos no se evidenciaron sueros positivos. Entre 1975 y 1985 los autores estudiaron 14 brotes en seres humanos en esta-blecimentos de procesamiento de carne, con un total de 1358 casos estudiados, habiéndose confirmado el 60% de ellos. Pasan revista a la sintomatologia común, así como el tipo de tarea de los pacientes. Para los estudios serológicos, como los diagnósticos de los casos clínicos, los autores utilizaron la fijación del complemento, la aglutinación capilar y la microa-glutinación en lámina.

  10. q-Derivatives, quantization methods and q-algebras

    International Nuclear Information System (INIS)

    Twarock, Reidun

    1998-01-01

    Using the example of Borel quantization on S 1 , we discuss the relation between quantization methods and q-algebras. In particular, it is shown that a q-deformation of the Witt algebra with generators labeled by Z is realized by q-difference operators. This leads to a discrete quantum mechanics. Because of Z, the discretization is equidistant. As an approach to a non-equidistant discretization of quantum mechanics one can change the Witt algebra using not the number field Z as labels but a quadratic extension of Z characterized by an irrational number τ. This extension is denoted as quasi-crystal Lie algebra, because this is a relation to one-dimensional quasicrystals. The q-deformation of this quasicrystal Lie algebra is discussed. It is pointed out that quasicrystal Lie algebras can be considered also as a 'deformed' Witt algebra with a 'deformation' of the labeling number field. Their application to the theory is discussed

  11. Minimum Q Electrically Small Antennas

    DEFF Research Database (Denmark)

    Kim, O. S.

    2012-01-01

    Theoretically, the minimum radiation quality factor Q of an isolated resonance can be achieved in a spherical electrically small antenna by combining TM1m and TE1m spherical modes, provided that the stored energy in the antenna spherical volume is totally suppressed. Using closed-form expressions...... for a multiarm spherical helix antenna confirm the theoretical predictions. For example, a 4-arm spherical helix antenna with a magnetic-coated perfectly electrically conducting core (ka=0.254) exhibits the Q of 0.66 times the Chu lower bound, or 1.25 times the minimum Q....

  12. Analysis of autism susceptibility gene loci on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q in Finnish multiplex families.

    Science.gov (United States)

    Auranen, M; Nieminen, T; Majuri, S; Vanhala, R; Peltonen, L; Järvelä, I

    2000-05-01

    The role of genetic factors in the etiology of the autistic spectrum of disorders has clearly been demonstrated. Ten chromosomal regions, on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q have potentially been linked to autism.1-8 We have analyzed these chromosomal regions in a total of 17 multiplex families with autism originating from the isolated Finnish population by pairwise linkage analysis and sib-pair analysis. Mild evidence for putative contribution was found only with the 1p chromosomal region in the susceptibility to autism. Our data suggest that additional gene loci exist for autism which will be detectable in and even restricted to the isolated Finnish population.

  13. Q Vara ehitab tootmismaad laopargiks

    Index Scriptorium Estoniae

    2007-01-01

    Kinnisvarafirma Q Vara OÜ alustab 2007. a. mais Rae vallas Tallinna ringtee ääres asuva 168000 m2 suuruse tootmismaa ümberehitamist laopargiks. Ettevõtte projektijuhi Jaak Puistma sõnul jagatakse laopark 22 krundiks

  14. FEMA Q3 Flood Data

    Data.gov (United States)

    Kansas Data Access and Support Center — The Q3 Flood Data are derived from the Flood Insurance Rate Maps (FIRMS) published by the Federal Emergency Management Agency (FEMA). The file is georeferenced to...

  15. Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q.

    Science.gov (United States)

    Saiki, Ryoichi; Lunceford, Adam L; Bixler, Tarra; Dang, Peter; Lee, Wendy; Furukawa, Satoru; Larsen, Pamela L; Clarke, Catherine F

    2008-06-01

    Coenzyme Q(n) is a fully substituted benzoquinone containing a polyisoprene tail of distinct numbers (n) of isoprene groups. Caenorhabditis elegans fed Escherichia coli devoid of Q(8) have a significant lifespan extension when compared to C. elegans fed a standard 'Q-replete'E. coli diet. Here we examine possible mechanisms for the lifespan extension caused by the Q-less E. coli diet. A bioassay for Q uptake shows that a water-soluble formulation of Q(10) is effectively taken up by both clk-1 mutant and wild-type nematodes, but does not reverse lifespan extension mediated by the Q-less E. coli diet, indicating that lifespan extension is not due to the absence of dietary Q per se. The enhanced longevity mediated by the Q-less E. coli diet cannot be attributed to dietary restriction, different Qn isoforms, reduced pathogenesis or slowed growth of the Q-less E. coli, and in fact requires E. coli viability. Q-less E. coli have defects in respiratory metabolism. C. elegans fed Q-replete E. coli mutants with similarly impaired respiratory metabolism due to defects in complex V also show a pronounced lifespan extension, although not as dramatic as those fed the respiratory deficient Q-less E. coli diet. The data suggest that feeding respiratory incompetent E. coli, whether Q-less or Q-replete, produces a robust life extension in wild-type C. elegans. We believe that the fermentation-based metabolism of the E. coli diet is an important parameter of C. elegans longevity.

  16. Linear q-nonuniform difference equations

    International Nuclear Information System (INIS)

    Bangerezako, Gaspard

    2010-01-01

    We introduce basic concepts of q-nonuniform differentiation and integration and study linear q-nonuniform difference equations and systems, as well as their application in q-nonuniform difference linear control systems. (author)

  17. Enabling ICH Q10 Implementation--Part 1. Striving for Excellence by Embracing ICH Q8 and ICH Q9.

    Science.gov (United States)

    Calnan, Nuala; O'Donnell, Kevin; Greene, Anne

    2013-01-01

    This article is the first in a series of articles that will focus on understanding the implementation essentials necessary to deliver operational excellence through a International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Q10-based pharmaceutical quality system (PQS). The authors examine why, despite the fact that the ICH Q10 guideline has been with us since 2008, the transformation of the traditional Quality Management Systems QMS in use within the pharmaceutical industry is a work in progress for only a few forward-thinking organisations. Unfortunately, this transformation remains a mere aspiration for the majority of organisations. We explore the apparent lack of progress by the pharmaceutical sector in adopting six sigma and related quality management techniques to ensure the availability of high-quality medicines worldwide. The authors propose that the desired progress can be delivered through two key shifts in our current practices; by embodying the principles of operational excellence in every aspect of our business and by learning how to unlock the scientific and tacit knowledge within our organisations. It has been ten years since The Wall Street Journal revealed the pharmaceutical industry's "little secret" comparing the perceived level of manufacturing expertise in the industry as lagging far behind those of potato-chip and laundry-soap makers. Would you consider the quality and manufacturing strategies in place today in your organisation to be more efficient and scientifically based than those of 2003? If so, what evidence exists for you to draw any conclusion regarding enhanced performance? Do your current practices drive innovation and facilitate continual improvement and if so, how? Ultimately, can you confidently affirm that patient-related risks associated with the product(s) manufactured by your organisation have been reduced due to the quality assurance program now applied

  18. Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor.

    Science.gov (United States)

    Fernández-Del-Río, Lucía; Nag, Anish; Gutiérrez Casado, Elena; Ariza, Julia; Awad, Agape M; Joseph, Akil I; Kwon, Ohyun; Verdin, Eric; de Cabo, Rafael; Schneider, Claus; Torres, Jorge Z; Burón, María I; Clarke, Catherine F; Villalba, José M

    2017-09-01

    Coenzyme Q (Q) is a lipid-soluble antioxidant essential in cellular physiology. Patients with Q deficiencies, with few exceptions, seldom respond to treatment. Current therapies rely on dietary supplementation with Q 10 , but due to its highly lipophilic nature, Q 10 is difficult to absorb by tissues and cells. Plant polyphenols, present in the human diet, are redox active and modulate numerous cellular pathways. In the present study, we tested whether treatment with polyphenols affected the content or biosynthesis of Q. Mouse kidney proximal tubule epithelial (Tkpts) cells and human embryonic kidney cells 293 (HEK 293) were treated with several types of polyphenols, and kaempferol produced the largest increase in Q levels. Experiments with stable isotope 13 C-labeled kaempferol demonstrated a previously unrecognized role of kaempferol as an aromatic ring precursor in Q biosynthesis. Investigations of the structure-function relationship of related flavonols showed the importance of two hydroxyl groups, located at C3 of the C ring and C4' of the B ring, both present in kaempferol, as important determinants of kaempferol as a Q biosynthetic precursor. Concurrently, through a mechanism not related to the enhancement of Q biosynthesis, kaempferol also augmented mitochondrial localization of Sirt3. The role of kaempferol as a precursor that increases Q levels, combined with its ability to upregulate Sirt3, identify kaempferol as a potential candidate in the design of interventions aimed on increasing endogenous Q biosynthesis, particularly in kidney. Copyright © 2017 Elsevier Inc. All rights reserved.

  19. Q-phonons, Q-invariants, and company

    International Nuclear Information System (INIS)

    Brentano, P. von; Gade, A.; Pietralla, N.; Werner, V.

    2002-01-01

    The paper discusses the concept of Q-phonons and its connection to the concept of Q-invariants and the shape parameters of nuclei. It will also discuss some useful relations between Q-invariants and observables. These relations allow one to determine crucial nuclear observables such as the square of the quadrupole moment of the first 2+ state from lifetime data of the gamma- and ground band which may have applications, in future measurements with rare isotopes beams. These concepts are discussed for the Barium, Xenon and Cerium nuclei with mass numbers around A = 130, because some of these concepts were either introduced or at least heavily used in the discussion of the nuclear structure of these nuclei

  20. Wave-equation Q tomography

    KAUST Repository

    Dutta, Gaurav

    2016-10-12

    Strong subsurface attenuation leads to distortion of amplitudes and phases of seismic waves propagating inside the earth. The amplitude and the dispersion losses from attenuation are often compensated for during prestack depth migration. However, most attenuation compensation or Qcompensation migration algorithms require an estimate of the background Q model. We have developed a wave-equation gradient optimization method that inverts for the subsurface Q distribution by minimizing a skeletonized misfit function ∈, where ∈ is the sum of the squared differences between the observed and the predicted peak/centroid-frequency shifts of the early arrivals. The gradient is computed by migrating the observed traces weighted by the frequency shift residuals. The background Q model is perturbed until the predicted and the observed traces have the same peak frequencies or the same centroid frequencies. Numerical tests determined that an improved accuracy of the Q model by wave-equation Q tomography leads to a noticeable improvement in migration image quality. © 2016 Society of Exploration Geophysicists.

  1. Low Q2 kaon electroproduction

    International Nuclear Information System (INIS)

    Markowitz, P.; Acha, A.

    2010-01-01

    A measurement of the H(e, e′ K + ) reaction was performed at Hall A, TJNAF as part of the hypernuclear experiment E94-107. Data was taken at very low Q 2 (~ 0.07 (GeV/c) 2 ) and W = 2.2 GeV. Kaons were detected along the direction of q-vector, the momentum transferred by the incident electron (θ CM = 6°). These measurements provide data about the Σ 0 /Λ ratio which drops rapidly with Q 2 , the angular dependence of the cross sections as Q 2 → 0, and the dependence of the cross section with respect to Q 2 ,W and θ CM . The dependence of the cross section at very forward angles has been poorly known. Available models are inadequate to describe the results. The measurement of the elementary cross section will constrain models for the elementary reaction which are inadequate to describe these results. It is also a key ingredient in the hypernuclear spectroscopy studies performed at the same kinematics. Details of the calculations and results will be shown. (author)

  2. Wave-equation Q tomography

    KAUST Repository

    Dutta, Gaurav; Schuster, Gerard T.

    2016-01-01

    Strong subsurface attenuation leads to distortion of amplitudes and phases of seismic waves propagating inside the earth. The amplitude and the dispersion losses from attenuation are often compensated for during prestack depth migration. However, most attenuation compensation or Qcompensation migration algorithms require an estimate of the background Q model. We have developed a wave-equation gradient optimization method that inverts for the subsurface Q distribution by minimizing a skeletonized misfit function ∈, where ∈ is the sum of the squared differences between the observed and the predicted peak/centroid-frequency shifts of the early arrivals. The gradient is computed by migrating the observed traces weighted by the frequency shift residuals. The background Q model is perturbed until the predicted and the observed traces have the same peak frequencies or the same centroid frequencies. Numerical tests determined that an improved accuracy of the Q model by wave-equation Q tomography leads to a noticeable improvement in migration image quality. © 2016 Society of Exploration Geophysicists.

  3. Quantum optical predictions in Q representation for Bell's type experiments

    International Nuclear Information System (INIS)

    Ferrero, M.; Marshall, T.W.

    1991-01-01

    Using the Q representation, the authors study the disagreement between quantum optical formalism and local realism and they show that the phenomenon of enhancement, first revealed by the local realist analysis, could receive a simple explanation if they use this particular version of the quantum formalism. Nevertheless, some fundamental difficulties remain

  4. Soliton solutions for Q3

    International Nuclear Information System (INIS)

    Atkinson, James; Nijhoff, Frank; Hietarinta, Jarmo

    2008-01-01

    We construct N-soliton solutions to the equation called Q3 in the recent Adler-Bobenko-Suris classification. An essential ingredient in the construction is the relationship of (Q3) δ=0 to the equation proposed by Nijhoff, Quispel and Capel in 1983 (the NQC equation). This latter equation has two extra parameters, and depending on their sign choices we get a 4-to-1 relationship from NQC to (Q3) δ=0 . This leads to a four-term background solution, and then to a 1-soliton solution using a Baecklund transformation. Using the 1SS as a guide allows us to get the N-soliton solution in terms of the τ-function of the Hirota-Miwa equation. (fast track communication)

  5. The new Audi Q3; Der neue Audi Q3

    Energy Technology Data Exchange (ETDEWEB)

    Liebl, Johannes; Siebenpfeiffer, Wolfgang (eds.)

    2011-07-15

    The contribution under consideration reports on the launch of the new Audi Q3 from Audi AG (Ingolstadt, Federal Republic of Germany). Design, drive, vehicle concept, driving dynamics, car body, interior, aerodynamics/aeroacoustics, driving assistance as well as vehicle safety are described.

  6. Balneotherapy and coenzyme Q10 in clinical and experimental medicine.

    Science.gov (United States)

    Gvozdjakova, Anna; Kucharska, Jarmila; Sykora, L'ubomir; Singh, Ram B

    2014-01-01

    Balneotherapy or Spa therapy is used in neurological, cardiovascular, musculoskeletal, dermatological and gynecological diseases, in infertility as well as in metabolic disturbances. Beneficial effects of balneotherapy at the metabolic level is not fully understood. Authors have documented enhancement of antioxidants concentrations (coenzyme Q10- CoQ(10-OX) and alpha-tocopherol) of women with gynecological diseases by treatment with natural mineral water (Spa Lucky balneotherapy, Slovakia). In an experiment with rats, drinking of Spa Lucky mineral water decreased oxidative stress and enhanced concentrations of antioxidants CoQ(9-OX), CoQ(10-OX) in the myocardium, and alpha-tocopherol in uterus, ovaries and myocardium. Drinking of Spa Lucky water by rats stimulated myocardial mitochondrial respiration and energy production, and diminished skeletal muscle mitochondrial function. Simultaneous ingestion of coenzyme Q10 with drinking spa water returned mitochondrial parameters to the values of the control group. This pilot study helps explain the role of antioxidants, oxidative stress and mitochondrial energy production in beneficial effects of Spa Lucky balneotherapy.

  7. q-Virasoro algebra, q-conformal dimensions and free q-superstring

    International Nuclear Information System (INIS)

    Chaichian, M.

    1996-01-01

    The commutators of standard Virasoro generators and fields generate various representations of the centreless Virasoro algebra depending on a conformal dimension J of the field in question (J is related to the Bargmann index of SU(1,1) generated by L m , m=0,±1). We introduce the notion of q-conformal dimension for various oscillator realizations of q-deformed Virasoro (super)algebras proposed earlier. We use the field theoretical approach introduced recently in which the q-Virasoro currents L α (z) are expressed as Schwinger-like point-split normally ordered quadratic expressions in elementary fields. We extend this approach and probe the elementary fields A(z) (the q-superstring coordinate, momentum and fermionic field) and their powers by the q-Virasoro generators L α m (i.e. we calculate the commutators [L α m ,A(z)]) and show that to all of them can be assigned just the standard non-deformed conformal dimension. (orig.)

  8. Some aspects of q-boson calculus

    International Nuclear Information System (INIS)

    Smirnov, Yu.F.; Kibler, M.R.

    1992-10-01

    The Jordan-Schwinger calculus is discussed, using deformed bosons. This work constitutes a first step toward a complete study of the SU q (2) unit tensor. The objective is to find a realization of the components of this tensor in terms of q-bosons. The q-deformed Schwinger algebra relative to SU q (2) is defined, and an algorithm for producing recurrent relations between Clebsch-Gordan coefficients for SU q (2) is given. (K.A.) 18 refs

  9. q Regulates the Development of Rheumatoid Arthritis by Modulating Th1 Differentiation.

    Science.gov (United States)

    Wang, Dashan; Liu, Yuan; Li, Yan; He, Yan; Zhang, Jiyun; Shi, Guixiu

    2017-01-01

    The G α q-containing G protein, an important member of G q/11 class, is ubiquitously expressed in mammalian cells. G α q has been found to play an important role in immune regulation and development of autoimmune disease such as rheumatoid arthritis (RA). However, how G α q participates in the pathogenesis of RA is still not fully understood. In the present study, we aimed to find out whether G α q controls RA via regulation of Th1 differentiation. We observed that the expression of G α q was negatively correlated with the expression of signature Th1 cytokine (IFN- γ ) in RA patients, which suggests a negative role of G α q in differentiation of Th1 cells. By using G α q knockout ( Gnaq-/- ) mice, we demonstrated that loss of G α q led to enhanced Th1 cell differentiation. G α q negative regulated the differentiation of Th1 cell by modulating the expression of T-bet and the activity of STAT4. Furthermore, we detected the increased ratio of Th1 cells in Gnaq-/- bone marrow (BM) chimeras spontaneously developing inflammatory arthritis. In conclusion, results presented in the study demonstrate that loss of G α q promotes the differentiation of Th1 cells and contributes to the pathogenesis of RA.

  10. Siblings with opposite chromosome constitutions, dup(2q)/del(7q) and del(2q)/dup(7q).

    Science.gov (United States)

    Shim, Sung Han; Shim, Jae Sun; Min, Kyunghoon; Lee, Hee Song; Park, Ji Eun; Park, Sang Hee; Hwang, Euna; Kim, Minyoung

    2014-01-15

    Chromosome 7q36 microdeletion syndrome is a rare genomic disorder characterized by underdevelopment of the brain, microcephaly, anomalies of the sex organs, and language problems. Developmental delay, intellectual disability, autistic spectrum disorders, BDMR syndrome, and unusual facial morphology are the key features of the chromosome 2q37 microdeletion syndrome. A genetic screening for two brothers with global developmental delay using high-resolution chromosomal analysis and subtelomeric multiplex ligation-dependent probe amplification revealed subtelomeric rearrangements on the same sites of 2q37.2 and 7q35, with reversed deletion and duplication. Both of them showed dysmorphic facial features, severe disability of physical and intellectual development, and abnormal genitalia with differential abnormalities in their phenotypes. The family did not have abnormal genetic phenotypes. According to the genetic analysis of their parents, adjacent-1 segregation from their mother's was suggested as a mechanism of their gene mutation. By comparing the phenotypes of our patients with previous reports on similar patients, we tried to obtain the information of related genes and their chromosomal locations. © 2013.

  11. q-conformally covariant q-Minkowski space-time and invariant equations

    International Nuclear Information System (INIS)

    Dobrev, V.K.

    1997-09-01

    We present explicitly the covariant action of the q-conformal algebra on the q-Minkowski space we proposed earlier. We also present some q-conformally invariant equations, namely a hierarchy of q-Maxwell equations, and also a q-d'Alembert equation, proposed earlier by us, in a form different from the original . (author). 19 refs

  12. Comparison of q anti qg and q anti qγ events in e+e- annihilation at PEP

    International Nuclear Information System (INIS)

    Hofmann, W.

    1986-07-01

    In comparing the particle flow in the event plane of three-jet (q anti qg) events and of radiative annihilation events (q anti qγ) for similar kinematic configurations, two PEP experiments find a significant decrease in particle density in the angular region opposite to the gluon jet in q anti qg events, relative to the particle density in the region opposite to the photon in q anti qγ events. The effect is predicted both by QCD and by phenomenological string models. 5 refs., 5 figs

  13. New infiniti Q45. Shingata Infiniti Q45'' ni tsuite

    Energy Technology Data Exchange (ETDEWEB)

    Oka, T; Ochiai, A; Kato, Y [Nissan Motor Co. Ltd., Tokyo (Japan)

    1989-12-25

    This report introduces the concept for development and the outline of the Infiniti Q45, a new luxury sedan Nissan has developed, and special activities Nissan makes to produce luxury cars. This sedan was developed with the concept of producing a large-sized luxury car of evidently Japanese make to earn the world appraisal; a touring saloon whose style is original and unique based on the sensitivity of Japanese and yet which has the performance of a sports car. Every part of the Infiniti Q45, from the V8 engine and the 4.5 L DOHC 32 valve engine to the hydraulic active suspension, the first to be loaded on a mass production car, features Nissan's innovative and leading-edge technology. Moreover, to provide maximum customer satisfaction in every scene from the purchase of a car to services, various constructive programs have been adopted with the key word, Total Ownership Experience. 8 figs., 2 tabs.

  14. Kepler Data Release 25 Notes (Q0-Q17)

    Science.gov (United States)

    Mullally, Susan E.; Caldwell, Douglas A.; Barclay, Thomas Stewart; Barentsen, Geert; Clarke, Bruce Donald; Bryson, Stephen T.; Burke, Christopher James; Campbell, Jennifer Roseanna; Catanzarite, Joseph H.; Christiansen, Jessie; hide

    2016-01-01

    These Data Release Notes provide information specific to the current reprocessing and re-export of the Q0-Q17 data. The data products included in this data release include target pixel files, light curve files, FFIs,CBVs, ARP, Background, and Collateral files. This release marks the final processing of the Kepler Mission Data. See Tables 1 and 2 for a list of the reprocessed Kepler cadence data. See Table 3 for a list of the available FFIs. The Long Cadence Data, Short Cadence Data, and FFI data are documented in these data release notes. The ancillary files (i.e., cotrending basis vectors, artifact removal pixels, background, and collateral data) are described in the Archive Manual (Thompson et al., 2016).

  15. Clinical, Molecular, and Prognostic Significance of WHO Type inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and Various Other 3q Abnormalities in Acute Myeloid Leukemia

    NARCIS (Netherlands)

    Lugthart, Sanne; Groschel, Stefan; Beverloo, H. Berna; Kayser, Sabine; Valk, Peter J. M.; van Zelderen-Bhola, Shama Lydia; Ossenkoppele, Gert Jan; Vellenga, Edo; van den Berg-de Ruiter, Eva; Schanz, Urs; Verhoef, Gregor; Vandenberghe, Peter; Ferrant, Augustin; Kohne, Claus-Henning; Pfreundschuh, Michael; Horst, Heinz A.; Koller, Elisabeth; von Lilienfeld-Toal, Marie; Bentz, Martin; Ganser, Arnold; Schlegelberger, Brigitte; Jotterand, Martine; Krauter, Jurgen; Pabst, Thomas; Theobald, Matthias; Schlenk, Richard F.; Delwel, Ruud; Dohner, Konstanze; Lowenberg, Bob; Doehner, Hartmut

    2010-01-01

    Purpose Acute myeloid leukemia (AML) with inv(3)(q21q26.2)/t(3; 3)(q21; q26.2) inv(3)/t(3; 3)] is recognized as a distinctive entity in the WHO classification. Risk assignment and clinical and genetic characterization of AML with chromosome 3q abnormalities other than inv(3)/t(3; 3) remain largely

  16. q-Sumudu transforms of q-analogues of Bessel functions.

    Science.gov (United States)

    Uçar, Faruk

    2014-01-01

    The main purpose of this paper is to evaluate q-Sumudu transforms of a product of q-Bessel functions. Interesting special cases of theorems are also discussed. Further, the results proved in this paper may find certain applications of q-Sumudu transforms to the solutions of the q-integrodifferential equations involving q-Bessel functions. The results may help to extend the q-theory of orthogonal functions.

  17. AXAIR89Q User's Manual

    International Nuclear Information System (INIS)

    Simpkins, A.A.

    1994-04-01

    AXAIR89Q is the primary dose assessment code used at the Savannah River Site to predict downwind doses following a hypothetical atmospheric release of relatively short duration. The primary purpose of the code is to perform calculations for safety-related documentation, and there is strict adherence in AXAIR89Q to the guidance in USNRC Regulatory Guide 1.145 (USNRC, 1983) entitled Atmospheric Dispersion Models for Potential Accident Consequence Assessments at Nuclear Power Plants. Doses are determined for the cloud shine, and inhalation pathways. Ingestion and ground shine are not considered. Future modifications are expected to include these features. This report discusses the information needed to execute the program and interpret the results

  18. Trends and risk factors for human Q fever in Australia, 1991-2014.

    Science.gov (United States)

    Sloan-Gardner, T S; Massey, P D; Hutchinson, P; Knope, K; Fearnley, E

    2017-03-01

    Australian abattoir workers, farmers, veterinarians and people handling animal birthing products or slaughtering animals continue to be at high risk of Q fever despite an effective vaccine being available. National Notifiable Diseases Surveillance System data were analysed for the period 1991-2014, along with enhanced risk factor data from notified cases in the states of New South Wales and Queensland, to examine changes in the epidemiology of Q fever in Australia. The national Q fever notification rate reduced by 20% [incident rate ratio (IRR) 0·82] following the end of the National Q fever Management Program in 2006, and has increased since 2009 (IRR 1·01-1·34). Highest rates were in males aged 40-59 years (5·9/100 000) and 87% of Q fever cases occurred in New South Wales and Queensland. The age of Q fever cases and proportion of females increased over the study period. Based on the enhanced risk factor data, the most frequently listed occupation for Q fever cases involved contact with livestock, followed by 'no known risk' occupations. More complete and comparable enhanced risk factor data, at the State/Territory and national levels, would aid in further understanding of the epidemiology of Q fever.

  19. Electrochemistry of Q-graphene.

    Science.gov (United States)

    Randviir, Edward P; Brownson, Dale A C; Gómez-Mingot, Maria; Kampouris, Dimitrios K; Iniesta, Jesús; Banks, Craig E

    2012-10-21

    A newly synthesised type of graphene, Q-Graphene, has been physically and electrochemically characterised with Scanning and Transmission Electron Microscopy (SEM, TEM), X-ray Photoelectron Spectroscopy (XPS) and Cyclic Voltammetry (CV). Interpretation of SEM, TEM and XPS data reveal the material to consist of hollow carbon nanospheres of multi-layer graphene (viz. graphite), which exhibit a total oxygen content of ca. 36.0% (atomic weight via XPS). In addition to the carbon structures present, spherical magnesium oxide particles of ≤50 nm in diameter are abundantly present in the sample (ca. 16.2%). Interestingly, although the TEM/SEM images show macroporous carbon structures, Raman spectroscopy shows peaks typically characteristic of graphene, which suggests the material is highly heterogeneous and consists of many types of carbon allotropes. Q-Graphene is electrochemically characterised using both inner-sphere and outer-sphere electrochemical redox probes, namely potassium ferrocyanide(II), hexaammine-ruthenium(III) chloride and hexachloroiridate(III), in addition to the biologically relevant and electroactive analytes, norepinephrine, β-nicotinamide adenine dinucleotide (NADH) and l-ascorbic acid. The electrochemical response of Q-Graphene is benchmarked against edge plane- and basal plane-pyrolytic graphite (EPPG and BPPG respectively), pristine graphene and graphite alternatives. Q-Graphene is found to exhibit fast electron transfer kinetics, likely due to its high proportion of folded edges and surface defects, exhibiting a response similar to that of EPPG - which exhibits fast electron transfer rates due to the high proportion of edge plane sites it possesses. Furthermore, we demonstrate that the specific oxygen content plays a pivotal role in dictating the observed electrochemical response, which is analyte dependant. Consequently there is potential for this new member of the graphene family to be beneficially utilised in various electrochemical

  20. Triply heavy tetraquark states with the $QQ\\bar{Q}\\bar{q}$ configuration

    OpenAIRE

    Chen, Kan; Liu, Xiang; Wu, Jing; Liu, Yan-Rui; Zhu, Shi-Lin

    2016-01-01

    In the framework of the color-magnetic interaction, we systematically investigate the mass splittings of the $QQ\\bar{Q}\\bar{q}$ tetraquark states and estimated their rough masses in this work. These systems include the explicitly exotic states $cc\\bar{b}\\bar{q}$ and $bb\\bar{c}\\bar{q}$ and the hidden exotic states $cc\\bar{c}\\bar{q}$, $cb\\bar{b}\\bar{q}$, $bc\\bar{c}\\bar{q}$, and $bb\\bar{b}\\bar{q}$. If a state around the estimated mass region could be observed, its nature as a genuine tetraquark ...

  1. Triply heavy tetraquark states with the QQ anti Q anti q configuration

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Kan; Liu, Xiang [Lanzhou University, School of Physical Science and Technology, Lanzhou (China); Lanzhou University and Institute of Modern Physics of CAS, Research Center for Hadron and CSR Physics, Lanzhou (China); Liu, Yan-Rui; Wu, Jing [Shandong University, School of Physics and Key Laboratory of Particle Physics and Particle Irradiation (MOE), Jinan (China); Zhu, Shi-Lin [Peking University, School of Physics and State Key Laboratory of Nuclear Physics and Technology, Beijing (China); Collaborative Innovation Center of Quantum Matter, Beijing (China); Peking University, Center of High Energy Physics, Beijing (China)

    2017-01-15

    In the framework of the color-magnetic interaction, we systematically investigate the mass splittings of the QQ anti Q anti q tetraquark states and estimate their rough masses in this work. These systems include the explicitly exotic states cc anti b anti q and bb anti c anti q and the hidden exotic states cc anti c anti q, cb anti b anti q, bc anti c anti q, and bb anti b anti q. If a state around the estimated mass region can be observed, its nature as a genuine tetraquark is favored. The strong decay patterns shown here will be helpful to the experimental search for these exotic states. (orig.)

  2. Exotic tetraquark states with the qq anti Q anti Q configuration

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Si-Qiang; Chen, Kan; Liu, Xiang [Lanzhou University, School of Physical Science and Technology, Lanzhou (China); Lanzhou University and Institute of Modern Physics, CAS, Research Center for Hadron and CSR Physics, Lanzhou (China); Liu, Yan-Rui [Shandong University, School of Physics and Key Laboratory of Particle Physics and Particle Irradiation (MOE), Jinan (China); Zhu, Shi-Lin [Peking University, School of Physics and State Key Laboratory of Nuclear Physics and Technology, Beijing (China); Collaborative Innovation Center of Quantum Matter, Beijing (China); Peking University, Center for High Energy Physics, Beijing (China)

    2017-10-15

    In this work, we study systematically the mass splittings of the qq anti Q anti Q (q = u, d, s and Q = c, b) tetraquark states with the color-magnetic interaction by considering color mixing effects and estimate roughly their masses. We find that the color mixing effect is relatively important for the J{sup P} = 0{sup +} states and possible stable tetraquarks exist in the nn anti Q anti Q (n = u, d) and ns anti Q anti Q systems either with J = 0 or with J = 1. Possible decay patterns of the tetraquarks are briefly discussed. (orig.)

  3. Minimum Data Set Q1a Report

    Data.gov (United States)

    U.S. Department of Health & Human Services — The MDS Q1a report summarizes, by state and county, percentages of residents that answered Yes to Q1a - Residents expresses or indicates preference to return to the...

  4. Functional differential equations for the q-Fourier transform of q-Gaussians

    International Nuclear Information System (INIS)

    Umarov, S; Queiros, S M Duarte

    2010-01-01

    In this paper the question 'is the q-Fourier transform of a q-Gaussian a q'-Gaussian (with some q') up to a constant factor?' is studied for the whole range of q in (- infty, 3). This question is connected with applicability of the q-Fourier transform in the study of limit processes in nonextensive statistical mechanics. Using the functional differential equation approach we prove that the answer is affirmative if and only if 1 ≤ q < 3, excluding two particular cases of q < 1, namely q=1/2 and q=2/3. Complementarily, we discuss some applications of the q-Fourier transform to nonlinear partial differential equations such as the porous medium equation.

  5. Functional differential equations for the q-Fourier transform of q-Gaussians

    Energy Technology Data Exchange (ETDEWEB)

    Umarov, S [Department of Mathematics, Tufts University, Medford, MA (United States); Queiros, S M Duarte, E-mail: sdqueiro@gmail.co [Unilever R and D Port Sunlight, Quarry Road East, Wirral, CH63 3JW (United Kingdom)

    2010-02-05

    In this paper the question 'is the q-Fourier transform of a q-Gaussian a q'-Gaussian (with some q') up to a constant factor?' is studied for the whole range of q in (- infty, 3). This question is connected with applicability of the q-Fourier transform in the study of limit processes in nonextensive statistical mechanics. Using the functional differential equation approach we prove that the answer is affirmative if and only if 1 <= q < 3, excluding two particular cases of q < 1, namely q=1/2 and q=2/3. Complementarily, we discuss some applications of the q-Fourier transform to nonlinear partial differential equations such as the porous medium equation.

  6. A q-deformed nonlinear map

    International Nuclear Information System (INIS)

    Jaganathan, Ramaswamy; Sinha, Sudeshna

    2005-01-01

    A scheme of q-deformation of nonlinear maps is introduced. As a specific example, a q-deformation procedure related to the Tsallis q-exponential function is applied to the logistic map. Compared to the canonical logistic map, the resulting family of q-logistic maps is shown to have a wider spectrum of interesting behaviours, including the co-existence of attractors-a phenomenon rare in one-dimensional maps

  7. Partial monosomy 8q and partial trisomy 9q due to the maternal translocation t(8;9(q24.3;q34.1)

    DEFF Research Database (Denmark)

    Tos, T; Alp, M Y; Eker, H K

    2014-01-01

    Partial trisomy 9q34-qter and partial monosomy 8q24.3-qter are very rare chromosomal abnormalities. Characteristic features of partial trisomy 9q34-qter are hypotonia, developmental delay, mild intellectual disability, dolichocephaly, distinct facial phenotype, long and thin fingers, and cardiac...

  8. Supersymmetric Q-balls theory and cosmology

    CERN Document Server

    Kusenko, A

    1999-01-01

    MSSM predicts the existence of Q-balls, some of which can be entirely stable. Both stable and unstable Q-balls can play an important role in cosmology. In particular, Affleck-Dine baryogenesis can result in a copious production of stable baryonic Q-balls, which can presently exist as a form of dark matter.

  9. Properties of ΣQ*, ΞQ* and ΩQ* heavy baryons in cold nuclear matter

    Science.gov (United States)

    Azizi, K.; Er, N.

    2018-02-01

    The in-medium properties of the heavy spin-3/2 ΣQ*, ΞQ* and ΩQ* baryons with Q being b or c quark are investigated. The shifts in some spectroscopic parameters of these particles due to the saturated cold nuclear matter are calculated. The variations of those parameters with respect to the changes in the density of the cold nuclear medium are studied, as well. It is observed that the parameters of ΣQ* baryons are considerably affected by the nuclear matter compared to the ΞQ* and ΩQ* particles that roughly do not see the medium. The results obtained may be used in analyses of the data to be provided by the in-medium experiments like PANDA.

  10. Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22.

    Directory of Open Access Journals (Sweden)

    Mine S Cicek

    Full Text Available A substantial proportion of familial colorectal cancer (CRC is not a consequence of known susceptibility loci, such as mismatch repair (MMR genes, supporting the existence of additional loci. To identify novel CRC loci, we conducted a genome-wide linkage scan in 356 white families with no evidence of defective MMR (i.e., no loss of tumor expression of MMR proteins, no microsatellite instability (MSI-high tumors, or no evidence of linkage to MMR genes. Families were ascertained via the Colon Cancer Family Registry multi-site NCI-supported consortium (Colon CFR, the City of Hope Comprehensive Cancer Center, and Memorial University of Newfoundland. A total of 1,612 individuals (average 5.0 per family including 2.2 affected were genotyped using genome-wide single nucleotide polymorphism linkage arrays; parametric and non-parametric linkage analysis used MERLIN in a priori-defined family groups. Five lod scores greater than 3.0 were observed assuming heterogeneity. The greatest were among families with mean age of diagnosis less than 50 years at 4q21.1 (dominant HLOD = 4.51, α = 0.84, 145.40 cM, rs10518142 and among all families at 12q24.32 (dominant HLOD = 3.60, α = 0.48, 285.15 cM, rs952093. Among families with four or more affected individuals and among clinic-based families, a common peak was observed at 15q22.31 (101.40 cM, rs1477798; dominant HLOD = 3.07, α = 0.29; dominant HLOD = 3.03, α = 0.32, respectively. Analysis of families with only two affected individuals yielded a peak at 8q13.2 (recessive HLOD = 3.02, α = 0.51, 132.52 cM, rs1319036. These previously unreported linkage peaks demonstrate the continued utility of family-based data in complex traits and suggest that new CRC risk alleles remain to be elucidated.

  11. A characterization of the desarguesian planes of order q2 by SL(2,q

    Directory of Open Access Journals (Sweden)

    D. A. Foulser

    1983-01-01

    Full Text Available The main result is that if the translation complement of a translation plane of order q2 contains a group isomorphic to SL(2,q and if the subgroups of order q are elations (shears, then the plane is Desarguesian. This generalizes earlier work of Walker, who assumed that the kernel of the plane contained GF(q.

  12. Best polynomial degree reduction on q-lattices with applications to q-orthogonal polynomials

    KAUST Repository

    Ait-Haddou, Rachid; Goldman, Ron

    2015-01-01

    We show that a weighted least squares approximation of q-Bézier coefficients provides the best polynomial degree reduction in the q-L2-norm. We also provide a finite analogue of this result with respect to finite q-lattices and we present applications of these results to q-orthogonal polynomials. © 2015 Elsevier Inc. All rights reserved.

  13. Various endocrine disorders in children with t(13;14(q10;q10 Robertsonian translocation

    Directory of Open Access Journals (Sweden)

    Byung Ho Choi

    2013-09-01

    Full Text Available Purpose45,XY,t(13;14(q10;q10 karyotype can suggest infertility associated with more or less severe oligospermia in male adults. In addition, 45,XX,t(13;14(q10;q10 karyotype carries reproductive risks such as miscarriage or infertility in female adults. However, reports on the phenotype of this karyotype in children are very rare. This study was done to observe various phenotypes of this karyotype in children.MethodsBetween January 2007 and December 2012, children diagnosed with 45,XY,t(13;14(q10;q10 or 45,XX,t(13;14(q10;q10 karyotype by chromosome analysis were analyzed retrospectively.ResultsEight children (5 boys and 3 girls were diagnosed with 45,XY,t(13;14(q10;q10 or 45,XX,t(13;14(q10;q10 karyotype. They ranged in age from 5 years and 6 months to 12 years and 4 months. The phenotypes of the study patients consisted of 1 hypogonadotrophic hypogonadism, 1 precocious puberty, 3 early puberty, 2 growth hormone deficiency (GHD (partial and 1 idiopathic short stature. As shown here t(13;14(q10;q10 Robertsonian translocation shows a wide range of phenotypes.ConclusionIt can be said that t(13;14(q10;q10 Robertsonian translocation shows various phenotypes from GHD to precocious puberty in children. Further large-scale studies are necessary.

  14. Clinical delineation of a patient with trisomy 12q23q24

    NARCIS (Netherlands)

    Bouman, Arjan; Schuitema, Anke; Pfundt, Rolph; van de Zande, Guillaume; Kleefstra, Tjitske

    2013-01-01

    Trisomies of 12q23q24 have been described rarely in literature. Only a few case-reports have been published so far almost exclusively reporting on neonates or young infants. We present a 16-year-old patient with a trisomy of 12q23.3q24.3. Full phenotypic evaluation at this age comprised: severe

  15. Best polynomial degree reduction on q-lattices with applications to q-orthogonal polynomials

    KAUST Repository

    Ait-Haddou, Rachid

    2015-06-07

    We show that a weighted least squares approximation of q-Bézier coefficients provides the best polynomial degree reduction in the q-L2-norm. We also provide a finite analogue of this result with respect to finite q-lattices and we present applications of these results to q-orthogonal polynomials. © 2015 Elsevier Inc. All rights reserved.

  16. q-entropy for symbolic dynamical systems

    International Nuclear Information System (INIS)

    Zhao, Yun; Pesin, Yakov

    2015-01-01

    For symbolic dynamical systems we use the Carathéodory construction as described in (Pesin 1997 Dimension Theory in Dynamical Systems, ConTemporary Views and Applications (Chicago: University of Chicago Press)) to introduce the notions of q-topological and q-metric entropies. We describe some basic properties of these entropies and in particular, discuss relations between q-metric entropy and local metric entropy. Both q-topological and q-metric entropies are new invariants respectively under homeomorphisms and metric isomorphisms of dynamical systems. (paper)

  17. q-Deformed KP Hierarchy and q-Deformed Constrained KP Hierarchy

    OpenAIRE

    He, Jingsong; Li, Yinghua; Cheng, Yi

    2006-01-01

    Using the determinant representation of gauge transformation operator, we have shown that the general form of $au$ function of the $q$-KP hierarchy is a $q$-deformed generalized Wronskian, which includes the $q$-deformed Wronskian as a special case. On the basis of these, we study the $q$-deformed constrained KP ($q$-cKP) hierarchy, i.e. $l$-constraints of $q$-KP hierarchy. Similar to the ordinary constrained KP (cKP) hierarchy, a large class of solutions of $q$-cKP hierarchy can be represent...

  18. The Q-angle and sport

    DEFF Research Database (Denmark)

    Hahn, Thomas; Foldspang, Anders

    1997-01-01

    Quadriceps muscle contraction tends to straighten the Q angle. We expected that sports comprising a high amount of quadriceps training could be associated with low Q angles. The aim of the present study was to estimate the Q angle in athletes and to investigate its potential associations with par......Quadriceps muscle contraction tends to straighten the Q angle. We expected that sports comprising a high amount of quadriceps training could be associated with low Q angles. The aim of the present study was to estimate the Q angle in athletes and to investigate its potential associations...... with participation in sport. Three hundred and thirty-nine athletes had their Q angle measured. The mean of right-side Q angles was higher than left side, and the mean Q angle was higher in women than in men. The Q angle was positively associated with years of jogging, and negatively with years of soccer, swimming...... and sports participation at all. It is concluded that the use of Q angle measurements is questionable....

  19. Group Delay of High Q Antennas

    DEFF Research Database (Denmark)

    Bahramzy, Pevand; Pedersen, Gert Frølund

    2013-01-01

    Group Delay variations versus frequency is an essential factor which can cause distortion and degradation in the signals. Usually this is an issue in wideband communication systems, such as satellite communication systems, which are used for transmitting wideband data. However, group delay can also...... become an issue, when working with high Q antennas, because of the steep phase shift over the frequency. In this paper, it is measured how large group delay variations can become, when going from a low Q antenna to a high Q antenna. The group delay of a low Q antenna is shown to be around 1.3 ns, whereas...... a high Q antenna has group delay of around 22 ns. It is due to this huge group delay variation characteristics of high Q antennas, that signal distortion might occur in the radio system with high Q antennas....

  20. Q-deformed systems and constrained dynamics

    International Nuclear Information System (INIS)

    Shabanov, S.V.

    1993-01-01

    It is shown that quantum theories of the q-deformed harmonic oscillator and one-dimensional free q-particle (a free particle on the 'quantum' line) can be obtained by the canonical quantization of classical Hamiltonian systems with commutative phase-space variables and a non-trivial symplectic structure. In the framework of this approach, classical dynamics of a particle on the q-line coincides with the one of a free particle with friction. It is argued that q-deformed systems can be treated as ordinary mechanical systems with the second-class constraints. In particular, second-class constrained systems corresponding to the q-oscillator and q-particle are given. A possibility of formulating q-deformed systems via gauge theories (first-class constrained systems) is briefly discussed. (orig.)

  1. Pharmacia Building Q, Skokie, Illinois

    Energy Technology Data Exchange (ETDEWEB)

    2002-12-01

    This case study was prepared as one in a series for the Laboratories for the 21st Century program, a joint endeavor of the U.S. Environmental Protection Agency and the U.S. Department of Energy's Federal Energy Management Program. The goal of this program is to foster greater energy efficiency in new and retrofit laboratory buildings in both the public and the private sectors. The energy-efficient elements of the laboratory featured in this case study-Pharmacia Corporation's new Building Q in Skokie, Illinois-include sustainable design, light-filled interior spaces for daylighting, energy-efficient fume hoods and other equipment, occupancy sensors to reduce lighting loads, and spectrally selective glazing to allow more light and less heat into the building. Water-saving fixtures are used, as well. Building Q has been certified Gold (the second highest rating) through the U.S. Green Building Council's Leadership in Energy and Environmental Design (LEED) system.

  2. On the q-exponential of matrix q-Lie algebras

    Directory of Open Access Journals (Sweden)

    Ernst Thomas

    2017-01-01

    Full Text Available In this paper, we define several new concepts in the borderline between linear algebra, Lie groups and q-calculus.We first introduce the ring epimorphism r, the set of all inversions of the basis q, and then the important q-determinant and corresponding q-scalar products from an earlier paper. Then we discuss matrix q-Lie algebras with a modified q-addition, and compute the matrix q-exponential to form the corresponding n × n matrix, a so-called q-Lie group, or manifold, usually with q-determinant 1. The corresponding matrix multiplication is twisted under τ, which makes it possible to draw diagrams similar to Lie group theory for the q-exponential, or the so-called q-morphism. There is no definition of letter multiplication in a general alphabet, but in this article we introduce new q-number systems, the biring of q-integers, and the extended q-rational numbers. Furthermore, we provide examples of matrices in suq(4, and its corresponding q-Lie group. We conclude with an example of system of equations with Ward number coeficients.

  3. Quasi quantum group covariant q-oscillators

    International Nuclear Information System (INIS)

    Schomerus, V.

    1992-05-01

    If q is a p-th root of unity there exists a quasi-co-associative truncated quantum group algebra U T q (sl 2 ) whose indecomposable representations are the physical representations of U q (sl 2 ), whose co-product yields the truneated tensor product of physical representations of U q (sl 2 ), and whose R-matrix satisfies quasi Yang Baxter equations. For primitive p-th roots q, we consider a 2-dimensional q-oscillator which admits U T q (sl 2 ) as a symmetry algebra. Its wave functions lie in a space F T q of 'functions on the truncated quantum plane', i.e. of polynomials in noncommuting complex coordinate functions z a , on which multiplication operators Z a and the elements of U T q (sl 2 ) can act. This illustrates the concept of quasi quantum planes. Due to the truncation, the Hilbert space of states is finite dimensional. The subspaces F T(n) of monomials in x a of n-th degree vanish for n ≥ p-1, and F T(n) carries the 2J+1 dimensional irreducible representation of U T q (sl 2 ) if n=2J, J=0, 1/2, ... 1/2(p-2). Partial derivatives δ a are introduced. We find a *-operation on the algebra of multiplication operators Z i and derivatives δ b such that the adjoints Z * a act as differentiation on the truncated quantum plane. Multiplication operators Z a ('creation operators') and their adjoints ('annihilation operators') obey q -1/2 -commutation relations. The *-operation is used to determine a positive definite scalar product on the truncated quantum plane F T q . Some natural candidates of Hamiltonians for the q-oscillators are determined. (orig./HSI)

  4. Coenzyme Q supplementation in pulmonary arterial hypertension

    Directory of Open Access Journals (Sweden)

    Jacqueline Sharp

    2014-01-01

    Full Text Available Mitochondrial dysfunction is a fundamental abnormality in the vascular endothelium and smooth muscle of patients with pulmonary arterial hypertension (PAH. Because coenzyme Q (CoQ is essential for mitochondrial function and efficient oxygen utilization as the electron carrier in the inner mitochondrial membrane, we hypothesized that CoQ would improve mitochondrial function and benefit PAH patients. To test this, oxidized and reduced levels of CoQ, cardiac function by echocardiogram, mitochondrial functions of heme synthesis and cellular metabolism were evaluated in PAH patients (N=8 in comparison to healthy controls (N=7, at baseline and after 12 weeks oral CoQ supplementation. CoQ levels were similar among PAH and control individuals, and increased in all subjects with CoQ supplementation. PAH patients had higher CoQ levels than controls with supplementation, and a tendency to a higher reduced-to-oxidized CoQ ratio. Cardiac parameters improved with CoQ supplementation, although 6-minute walk distances and BNP levels did not significantly change. Consistent with improved mitochondrial synthetic function, hemoglobin increased and red cell distribution width (RDW decreased in PAH patients with CoQ, while hemoglobin declined slightly and RDW did not change in healthy controls. In contrast, metabolic and redox parameters, including lactate, pyruvate and reduced or oxidized gluthathione, did not change in PAH patients with CoQ. In summary, CoQ improved hemoglobin and red cell maturation in PAH, but longer studies and/or higher doses with a randomized placebo-controlled controlled design are necessary to evaluate the clinical benefit of this simple nutritional supplement.

  5. Electrical tuning of mechanical characteristics in qPlus sensor: Active Q and resonance frequency control

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Manhee; Hwang, Jong Geun; Jahng, Junghoon; Kim, QHwan; Noh, Hanaul; An, Sangmin; Jhe, Wonho, E-mail: whjhe@snu.ac.kr [Department of Physics and Astronomy, Institute of Applied Physics and Centre for THz-Bio Application Systems, Seoul National University, Seoul 151-747 (Korea, Republic of)

    2016-08-21

    We present an electrical feedback method for independent and simultaneous tuning of both the resonance frequency and the quality factor of a harmonic oscillator, the so called “qPlus” configuration of quartz tuning forks. We incorporate a feedback circuit with two electronic gain parameters into the original actuation-detection system, and systematically demonstrate the control of the original resonance frequency of 32 592 Hz from 32 572 Hz to 32 610 Hz and the original quality factor 952 from 408 up to 20 000. This tunable module can be used for enhancing and optimizing the oscillator performance in compliance with specifics of applications.

  6. Electrical tuning of mechanical characteristics in qPlus sensor: Active Q and resonance frequency control

    International Nuclear Information System (INIS)

    Lee, Manhee; Hwang, Jong Geun; Jahng, Junghoon; Kim, QHwan; Noh, Hanaul; An, Sangmin; Jhe, Wonho

    2016-01-01

    We present an electrical feedback method for independent and simultaneous tuning of both the resonance frequency and the quality factor of a harmonic oscillator, the so called “qPlus” configuration of quartz tuning forks. We incorporate a feedback circuit with two electronic gain parameters into the original actuation-detection system, and systematically demonstrate the control of the original resonance frequency of 32 592 Hz from 32 572 Hz to 32 610 Hz and the original quality factor 952 from 408 up to 20 000. This tunable module can be used for enhancing and optimizing the oscillator performance in compliance with specifics of applications.

  7. Qq(Q-bar)(q-bar)' states in chiral SU(3) quark model

    International Nuclear Information System (INIS)

    Zhang Haixia; Zhang Min; Zhang Zongye

    2007-01-01

    We study the masses of Qq(Q-bar)(q-bar)' states with J PC =0 ++ , 1 ++ , 1 +- and 2 ++ in the chiral SU(3) quark model, where Q is the heavy quark (c or b) and q(q') is the light quark (u,d or s). According to our numerical results, it is improbable to make the interpretation of [cn(c-bar)(n-bar)] 1 ++ and [cn(c-bar)(n-bar)] 2 ++ (n=u,d) states as X(3872) and Y(3940), respectively. However, it is interesting to find the tetraquarks in the bq(b-bar)(q-bar)' system. (authors)

  8. Discrete q-derivatives and symmetries of q-difference equations

    Energy Technology Data Exchange (ETDEWEB)

    Levi, D [Dipartimento di Fisica, Universita Roma Tre and INFN-Sezione di Roma Tre, Via della Vasca Navale 84, 00146 Rome (Italy); Negro, J [Departamento de FIsica Teorica, Universidad de Valladolid, E-47011, Valladolid (Spain); Olmo, M A del [Departamento de FIsica Teorica, Universidad de Valladolid, E-47011, Valladolid (Spain)

    2004-03-12

    In this paper we extend the umbral calculus, developed to deal with difference equations on uniform lattices, to q-difference equations. We show that many properties considered for shift invariant difference operators satisfying the umbral calculus can be implemented to the case of the q-difference operators. This q-umbral calculus can be used to provide solutions to linear q-difference equations and q-differential delay equations. To illustrate the method, we will apply the obtained results to the construction of symmetry solutions for the q-heat equation.

  9. q-analogue of summability of formal solutions of some linear q-difference-differential equations

    Directory of Open Access Journals (Sweden)

    Hidetoshi Tahara

    2015-01-01

    Full Text Available Let \\(q\\gt 1\\. The paper considers a linear \\(q\\-difference-differential equation: it is a \\(q\\-difference equation in the time variable \\(t\\, and a partial differential equation in the space variable \\(z\\. Under suitable conditions and by using \\(q\\-Borel and \\(q\\-Laplace transforms (introduced by J.-P. Ramis and C. Zhang, the authors show that if it has a formal power series solution \\(\\hat{X}(t,z\\ one can construct an actual holomorphic solution which admits \\(\\hat{X}(t,z\\ as a \\(q\\-Gevrey asymptotic expansion of order \\(1\\.

  10. Genetics Home Reference: distal 18q deletion syndrome

    Science.gov (United States)

    ... 18q deletion syndrome chromosome 18q monosomy chromosome 18q- syndrome De Grouchy syndrome del(18q) syndrome monosomy 18q Related Information How ... MS, Tienari PJ, Wirtavuori KO, Valanne LK. 18q-syndrome: brain MRI shows poor differentiation of gray and white matter on ... RL, Hale DE, Rose SR, Leach RJ, Cody JD. The spectrum ...

  11. Coenzyme Q10 and Neurological Diseases

    Directory of Open Access Journals (Sweden)

    Gabriele Siciliano

    2009-12-01

    Full Text Available Coenzyme Q10 (CoQ10, or ubiquinone is a small electron carrier of the mitochondrial respiratory chain with antioxidant properties. CoQ10 supplementation has been widely used for mitochondrial disorders. The rationale for using CoQ10 is very powerful when this compound is primary decreased because of defective synthesis. Primary CoQ10 deficiency is a treatable condition, so heightened “clinical awareness” about this diagnosis is essential. CoQ10 and its analogue, idebenone, have also been widely used in the treatment of other neurodegenerative disorders. These compounds could potentially play a therapeutic role in Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, Friedreich’s ataxia, and other conditions which have been linked to mitochondrial dysfunction. This article reviews the physiological roles of CoQ10, as well as the rationale and the role in clinical practice of CoQ10 supplementation in different neurological diseases, from primary CoQ10 deficiency to neurodegenerative disorders.

  12. Biochemical Assessment of Coenzyme Q10 Deficiency

    Directory of Open Access Journals (Sweden)

    Juan Carlos Rodríguez-Aguilera

    2017-03-01

    Full Text Available Coenzyme Q10 (CoQ10 deficiency syndrome includes clinically heterogeneous mitochondrial diseases that show a variety of severe and debilitating symptoms. A multiprotein complex encoded by nuclear genes carries out CoQ10 biosynthesis. Mutations in any of these genes are responsible for the primary CoQ10 deficiency, but there are also different conditions that induce secondary CoQ10 deficiency including mitochondrial DNA (mtDNA depletion and mutations in genes involved in the fatty acid β-oxidation pathway. The diagnosis of CoQ10 deficiencies is determined by the decrease of its content in skeletal muscle and/or dermal skin fibroblasts. Dietary CoQ10 supplementation is the only available treatment for these deficiencies that require a rapid and distinct diagnosis. Here we review methods for determining CoQ10 content by HPLC separation and identification using alternative approaches including electrochemical detection and mass spectrometry. Also, we review procedures to determine the CoQ10 biosynthesis rate using labeled precursors.

  13. Heavy-Quark Symmetry Implies Stable Heavy Tetraquark Mesons Q_{i}Q_{j}q[over ¯]_{k}q[over ¯]_{l}.

    Science.gov (United States)

    Eichten, Estia J; Quigg, Chris

    2017-11-17

    For very heavy quarks Q, relations derived from heavy-quark symmetry predict the existence of novel narrow doubly heavy tetraquark states of the form Q_{i}Q_{j}q[over ¯]_{k}q[over ¯]_{l} (subscripts label flavors), where q designates a light quark. By evaluating finite-mass corrections, we predict that double-beauty states composed of bbu[over ¯]d[over ¯], bbu[over ¯]s[over ¯], and bbd[over ¯]s[over ¯] will be stable against strong decays, whereas the double-charm states ccq[over ¯]_{k}q[over ¯]_{l}, mixed beauty+charm states bcq[over ¯]_{k}q[over ¯]_{l}, and heavier bbq[over ¯]_{k}q[over ¯]_{l} states will dissociate into pairs of heavy-light mesons. Observation of a new double-beauty state through its weak decays would establish the existence of tetraquarks and illuminate the role of heavy color-antitriplet diquarks as hadron constituents.

  14. Q-balls in flat potentials

    International Nuclear Information System (INIS)

    Copeland, Edmund J.; Tsumagari, Mitsuo I.

    2009-01-01

    We study the classical and absolute stability of Q-balls in scalar field theories with flat potentials arising in both gravity-mediated and gauge-mediated models. We show that the associated Q-matter formed in gravity-mediated potentials can be stable against decay into their own free particles as long as the coupling constant of the nonrenormalizable term is small, and that all of the possible three-dimensional Q-ball configurations are classically stable against linear fluctuations. Three-dimensional gauge-mediated Q-balls can be absolutely stable in the thin-wall limit, but are completely unstable in the thick-wall limit.

  15. The C1q family of proteins: insights into the emerging non-traditional functions

    Directory of Open Access Journals (Sweden)

    Berhane eGhebrehiwet

    2012-04-01

    Full Text Available Research conducted over the past 20 years have helped us unravel not only the hidden structural and functional subtleties of human C1q, but also has catapulted the molecule from a mere recognition unit of the classical pathway to a well-recognized molecular sensor of damage modified self or non-self antigens. Thus, C1q is involved in a rapidly expanding list of pathological disorders—including autoimmunity, trophoblast migration, preeclampsia and cancer. The results of two recent reports are provided to underscore the critical role C1q plays in health and disease. First is the observation by Singh and colleagues showing that pregnant C1q-/- mice recapitulate the key features of human preeclampsia that correlate with increased fetal death. Treatment of the C1q-/- mice with pravastatin restored trophoblast invasiveness, placental blood flow, and angiogenic balance and, thus, prevented the onset of preeclampsia. Second is the report by Hong et al., which showed that C1q can induce apoptosis of prostate cancer cells by activating the tumor suppressor molecule WW-domain containing oxydoreductase (WWOX or WOX1 and destabilizing cell adhesion. Downregulation of C1q on the other hand enhanced prostate hyperplasia and cancer formation due to failure of WOX1 activation. Recent evidence also shows that C1q belongs to a family of structurally and functionally related TNFα-like family of proteins that may have arisen from a common ancestral gene. Therefore C1q not only shares the diverse functions with the TNF family of proteins, but also explains why C1q has retained some of its ancestral cytokine-like activities. This review is intended to highlight some of the structural and functional aspects of C1q by underscoring the growing list of its non-traditional functions.

  16. Q-profile requirements for electro ITB formation

    Energy Technology Data Exchange (ETDEWEB)

    Goodman, T. P.; Coda, S.; Henderson, M. A.; Sauter, O.; Behn, R.; Bottino, A.; Fable, E.; Martynov, A.; Nikkola, P.; Zucca, C.

    2005-07-01

    The formation requirements of ITBs on numerous tokamaks have been correlated with either a power threshold, appearance of a low order rational surface near q{sub m}in or q{sub 9}5, weak or negative shear, etc. On TCV, electron ITBs (eITBs) can be formed during a gradual evolution from a centrally peaked to hollow current profile while all external actuators are held constant. The formation occurs rapidly (<{tau}{sub e}E) and locally and, according to ASTRA modeling, is correlated with the appearance of a local minimum in the q-profile. There is no clear evidence that the minimum in q appears at a low order rational. These eITBs are sustained by non-inductively driven current (ECCD and bootstrap current) while the current in the tokamak transformer is beld constant. Thus, they are not inherently transient but can exist for several current redistribution times; limited only by the pulse length of the gyrotrons. After the barrier is formed, the gransformer coil can be used as a counter (or co-) current source with negligible accompanying input power. The eITB performance can be enhanced (degraded) by altering solely the current or q-profile: when negative (positive) inductive current is driven, the on-axis current density decreases (increases) resulting in a stronger (weaker) reversed shear as both the ECCD and bootstrap currents are peaked off-axis. These experiments provide a unique realm of eITB formation and performance characteristics that can be used to isolate the physics criteria governing the eITB. (Author)

  17. Absorption band Q model for the earth

    International Nuclear Information System (INIS)

    Anderson, D.L.; Given, J.W.

    1982-01-01

    Body wave, surface wave, and normal mode data are used to place constraints on the frequency dependence of Q in the mantle. With a simple absorption band model it is possible to satisfy the shear sensitive data over a broad frequency range. The quality factor Q/sub s/(ω) is proportional to ω/sup α/ in the band and to ω and ω -1 at higher and lower frequencies, respectively, as appropriate for a relaxation mechanism with a spectrum of relaxation time. The parameters of the band are Q(min) = 80, α = 0.15, and width, 5 decades. The center of the band varies from 10 1 seconds in the upper mantle, to 1.6 x 10 3 seconds in the lower mantle. The shift of the band with depth is consistent with the expected effects of temperature, pressure and stress. High Q, regions of the mantle are attributed to a shift of the absorption band to longer periods. To satisfy the gravest fundamental spheroidal modes and the ScS data, the absorption band must shift back into the short-period seismic band at the base of the mantle. This may be due to a high temperature gradient or high shear stresses. A preliminary attempt is also made to specify bulk dissipation in the mantle and core. Specific features of the absorption band model are low Q in the body wave band at both the top and the base of the mantle, low Q for long-period body waves in the outer core, an inner core Q 2 that increases with period, and low Q/sub p//Q/sub s/ at short periods in the middle mantel. The short-period Q/sub s/ increases rapidly at 400 km and is relatively constant from this depth to 2400 km. The deformational Q of the earth at a period of 14 months is predicted to be 463

  18. A q-Schroedinger algebra, its lowest weight representations and generalized q-deformed heat equations

    International Nuclear Information System (INIS)

    Dobrev, V.K.; Doebner, H.D.; Mrugalla, C.

    1995-12-01

    We give a q-deformation S-perpendicular q of the centrally extended Schroedinger algebra. We construct the lowest weight representations of S-perpendicular q , starting from the Verma modules over S-perpendicular q , finding their singular vectors and factoring the Verma submodules built on the singular vectors. We also give a vector-field realization of S-perpendicular q which provides polynomial realization of the lowest weight representations and an infinite hierarchy of q-difference equations which may be called generalized q-deformed heat equations. We also apply our methods to the on-shell q-Schroedinger algebra proposed by Floreanini and Vinet. (author). 12 refs

  19. Some approximation properties of ( p , q $(p,q$ -Bernstein operators

    Directory of Open Access Journals (Sweden)

    Shin Min Kang

    2016-06-01

    Full Text Available Abstract This paper is concerned with the ( p , q $(p,q$ -analog of Bernstein operators. It is proved that, when the function is convex, the ( p , q $(p,q$ -Bernstein operators are monotonic decreasing, as in the classical case. Also, some numerical examples based on Maple algorithms that verify these properties are considered. A global approximation theorem by means of the Ditzian-Totik modulus of smoothness and a Voronovskaja type theorem are proved.

  20. The exponent λ (x,Q ) of the proton structure function F (x, Q ) at low ...

    Indian Academy of Sciences (India)

    from the gluon (g —q¯q) and so the contribution from the quark can be neglected. In the DGLAP formalism an approximate relationship can be obtained between the gluon momentum density G(x,Q2) and the logarithmic slope of the structure function F2(x,Q2). There are several such relations [6–8] available in the literature.

  1. Q-Technique and Graphics Research.

    Science.gov (United States)

    Kahle, Roger R.

    Because Q-technique is as appropriate for use with visual and design items as for use with words, it is not stymied by the topics one is likely to encounter in graphics research. In particular Q-technique is suitable for studying the so-called "congeniality" of typography, for various copytesting usages, and for multivariate graphics research. The…

  2. Coenzyme Q10 effects in neurodegenerative disease

    Directory of Open Access Journals (Sweden)

    Meredith Spindler

    2009-11-01

    Full Text Available Meredith Spindler1, M Flint Beal1,2, Claire Henchcliffe1,21Department of Neurology, 2Department of Neuroscience, Weill Medical College of Cornell University, New York, NY, USAAbstract: Coenzyme Q10 (CoQ10 is an essential cofactor in the mitochondrial respiratory chain, and as a dietary supplement it has recently gained attention for its potential role in the treatment of neurodegenerative disease. Evidence for mitochondrial dysfunction in neurodegenerative disorders derives from animal models, studies of mitochondria from patients, identification of genetic defects in patients with neurodegenerative disease, and measurements of markers of oxidative stress. Studies of in vitro models of neuronal toxicity and animal models of neurodegenerative disorders have demonstrated potential neuroprotective effects of CoQ10. With this data in mind, several clinical trials of CoQ10 have been performed in Parkinson’s disease and atypical Parkinson’s syndromes, Huntington’s disease, Alzheimer disease, Friedreich’s ataxia, and amyotrophic lateral sclerosis, with equivocal findings. CoQ10 is widely available in multiple formulations and is very well tolerated with minimal adverse effects, making it an attractive potential therapy. Phase III trials of high-dose CoQ10 in large sample sizes are needed to further ascertain the effects of CoQ10 in neurodegenerative diseases.Keywords: coenzyme Q10, neurodegenerative disease, Parkinson’s disease, Huntington’s disease, mitochondrial dysfunction

  3. Fuzzy torus via q-Parafermion

    International Nuclear Information System (INIS)

    Aizawa, N; Chakrabarti, R

    2007-01-01

    We note that the recently introduced fuzzy torus can be regarded as a q-deformed parafermion. Based on this picture, classification of the Hermitian representations of the fuzzy torus is carried out. The result involves Fock-type representations and new finite-dimensional representations for q being a root of unity as well as already known finite-dimensional ones

  4. 3q27.3 microdeletional syndrome

    DEFF Research Database (Denmark)

    Thevenon, Julien; Callier, Patrick; Poquet, Hélène

    2014-01-01

    BACKGROUND: Since the advent of array-CGH, numerous new microdeletional syndromes have been delineated while others remain to be described. Although 3q29 subtelomeric deletion is a well-described syndrome, there is no report on 3q interstitial deletions. METHODS: We report for the first time seve...

  5. individual maxims and the redaction of q

    African Journals Online (AJOL)

    differently, the article is not motivated by the incorrect notion that wisdom, prophecy and ... is motivated by a concern for Q's literary development, and is not biased by ...... like a mustard seed” (Q 17:6), but it would also have been the stratum's.

  6. Understanding Insight in the Context of Q

    Science.gov (United States)

    Coghlan, David

    2012-01-01

    In Revans' learning formula, L = P + Q, Q represents "questioning insight", by which Revans means that insight comes out of the process of questioning programmed knowledge (P) in the light of experience. We typically focus on the content of an insight rather than on the act of insight. Drawing primarily on the work of Bernard Lonergan this paper…

  7. q-fractional calculus and equations

    CERN Document Server

    Annaby, Mahmoud H

    2012-01-01

    This nine-chapter monograph introduces a rigorous investigation of q-difference operators in standard and fractional settings. It starts with elementary calculus of q-differences and integration of Jackson’s type before turning to q-difference equations. The existence and uniqueness theorems are derived using successive approximations, leading to systems of equations with retarded arguments. Regular  q-Sturm–Liouville theory is also introduced; Green’s function is constructed and the eigenfunction expansion theorem is given. The monograph also discusses some integral equations of Volterra and Abel type, as introductory material for the study of fractional q-calculi. Hence fractional q-calculi of the types Riemann–Liouville; Grünwald–Letnikov;  Caputo;  Erdélyi–Kober and Weyl are defined analytically. Fractional q-Leibniz rules with applications  in q-series are  also obtained with rigorous proofs of the formal  results of  Al-Salam-Verma, which remained unproved for decades. In working ...

  8. Stability properties of Q-stars

    International Nuclear Information System (INIS)

    Becerril, R.; Bernal, A.; Guzman, F.S.; Nucamendi, U.

    2007-01-01

    We present the evolution of Q-star configurations using numerical methods. We solve the full Einstein-Klein-Gordon system of equations and show that: Q-stars can be stable and unstable. The unstable branch is two fold: configurations with negative binding energy that collapse and form black holes, and others with positive binding energy that explode and release the scalar field

  9. Q and you: The application of Q methodology in recreation research

    Science.gov (United States)

    Whitney. Ward

    2010-01-01

    Researchers have used various qualitative and quantitative methods to deal with subjectivity in studying people's recreation experiences. Q methodology has been the most effective approach for analyzing both qualitative and quantitative aspects of experience, including attitudes or perceptions. The method is composed of two main components--Q sorting and Q factor...

  10. Numerical and Experimental Study of the Q Factor of High-Q Micropillar Cavities

    DEFF Research Database (Denmark)

    Gregersen, Niels; Reitzenstein, S.; Kistner, C.

    2010-01-01

    Micropillar cavities are potential candidates for high-efficiency single-photon sources and are testbeds for cavity quantum electrodynamics experiments. In both applications a high quality (Q) factor is desired. It was recently shown that the Q of high-Q semiconductor micropillar cavities exhibit...

  11. 18q- and 18q+ mosaicism in a mentally retarded boy

    NARCIS (Netherlands)

    Ausems, M. G.; Bhola, S. L.; Post-Blok, C. A.; Hennekam, R. C.; de France, H. F.

    1994-01-01

    A mentally retarded boy was found to have an unusual chromosomal mosaicism [46,XY, del(18) (q22)/46,XY,iso psu dic(18)(q23)]. The clinical manifestations are compatible with the 18q- syndrome. The chromosome alteration was defined by high resolution banding and fluorescence in situ hybridization

  12. q-trace for quantum groups and q-deformed Yang-Mills theory

    International Nuclear Information System (INIS)

    Isaev, A.P.; Popowicz, Z.

    1992-01-01

    The definitions of orbits and q-trace for the quantum groups are introduced. Then the q-trace is used to construct the invariants for the quantum group orbits and to formulate the q-deformed Yang-Mills theory. The amusing formal relation of the Weinberg type mixing angle with the quantum group deformation parameter is discussed. (orig.)

  13. q-deformed Weinberg-Salam model and q-deformed Maxwell equations

    International Nuclear Information System (INIS)

    Alavi, S.A.; Sarbishaei, M.; Mokhtari, A.

    2000-01-01

    We study the q-deformation of the gauge part of the Weinberg-Salam model and show that the q-deformed theory involves new interactions. We then obtain q-deformed Maxwell equations from which magnetic monopoles appear naturally. (author)

  14. Big Five Measurement via Q-Sort

    Directory of Open Access Journals (Sweden)

    Chris D. Fluckinger

    2014-08-01

    Full Text Available Socially desirable responding presents a difficult challenge in measuring personality. I tested whether a partially ipsative measure—a normatively scored Q-sort containing traditional Big Five items—would produce personality scores indicative of less socially desirable responding compared with Likert-based measures. Across both instructions to respond honestly and in the context of applying for a job, the Q-sort produced lower mean scores, lower intercorrelations between dimensions, and similar validity in predicting supervisor performance ratings to Likert. In addition, the Q-sort produced a more orthogonal structure (but not fully orthogonal when modeled at the latent level. These results indicate that the Q-sort method did constrain socially desirable responding. Researchers and practitioners should consider Big Five measurement via Q-sort for contexts in which high socially desirable responding is expected.

  15. Olanzapine induced Q-Tc shortening.

    Science.gov (United States)

    Shoja Shafti, Saeed; Fallah Jahromi, Parisa

    2014-12-01

    Prolongation of Q-Tc interval is commonly accepted as a surrogate marker for the ability of a drug to cause torsade de pointes. In the present study, safety of olanzapine versus risperidone was compared among a group of patients with schizophrenia to see the frequency of the electrocardiographic alterations induced by those atypical antipsychotics. Two hundred and sixty-eight female inpatients with schizophrenia entered in one of the two parallel groups to participate in an open study for random assignment to olanzapine (n = 148) or risperidone (n = 120). Standard 12-lead surface electrocardiogram (ECG) was taken from each patient at baseline, before initiation of treatment, and then at the end of management, just before discharge. The parameters that were assessed included heart rate (HR), P-R interval, QRS interval, Q-T interval (corrected = Q-Tc), ventricular activation time (VAT), ST segment, T wave, axis of QRS, and finally, interventricular conduction process. A total of 37.83% of cases in the olanzapine group and 30% in the risperidone group showed some Q-Tc changes; 13.51% and 24.32% of the patients in the olanzapine group showed prolongation and shortening of the Q-Tc, respectively, while changes in the risperidone group were restricted to only prolongation of Q-Tc. Comparison of means showed a significant increment in Q-Tc by risperidone (p = 0.02). Also, comparison of proportions in the olanzapine group showed significantly more cases with shortening of Q-Tc versus its prolongation (p = 0.01). No significant alterations with respect to other variables were evident. Olanzapine and risperidone had comparable potentiality for induction of Q-Tc changes, while production of further miscellaneous alterations in ECG was more observable in the olanzapine group compared with the risperidone group. Also shortening of Q-Tc was specific to olanzapine.

  16. Q46 Technology Refreshment Assessment

    Science.gov (United States)

    Garcia-Burgos, Axel A.

    2010-01-01

    This document reviews the accomplishments of the author during an internship. During this internship, the author was assigned to the End User Services Office, which coordinates and oversees a wide selection of information technologies that enhance the productivity of the workforce at NASA Kennedy Space Center. During the internship the author performed an assessment of the work of the Outsourcing Desktop Initiative for NASA (ODIN) contract.

  17. A case of de novo duplication of 15q24-q26.3

    Directory of Open Access Journals (Sweden)

    Hye Ran Kim

    2011-06-01

    Full Text Available Distal duplication, or trisomy 15q, is an extremely rare chromosomal disorder characterized by prenatal and postnatal overgrowth, mental retardation, and craniofacial malformations. Additional abnormalities typically include an unusually short neck, malformations of the fingers and toes, scoliosis and skeletal malformations, genital abnormalities, particularly in affected males, and, in some cases, cardiac defects. The range and severity of symptoms and physical findings may vary from case to case, depending upon the length and location of the duplicated portion of chromosome 15q. Most reported cases of duplication of the long arm of chromosome 15 frequently have more than one segmental imbalance resulting from unbalanced translocations involving chromosome 15 and deletions in another chromosome, as well as other structural chromosomal abnormalities. We report a female newborn with a de novo duplication, 15q24- q26.3, showing intrauterine overgrowth, a narrow asymmetric face with down-slanting palpebral fissures, a large, prominent nose, and micrognathia, arachnodactyly, camptodactyly, congenital heart disease, hydronephrosis, and hydroureter. Chromosomal analysis showed a 46,XX,inv(9(p12q13,dup(15(q24q26.3. Array comparative genomic hybridization analysis revealed a gain of 42 clones on 15q24-q26.3. This case represents the only reported patient with a de novo 15q24-q26.3 duplication that did not result from an unbalanced translocation and did not have a concomitant monosomic component in Korea.

  18. Economic significance of Q for mirror reactors: combinations of Q and M which look promising

    International Nuclear Information System (INIS)

    Werner, R.W.

    1978-01-01

    This term Q is the ratio of the fusion powder produced to the power input. It is a driven device. Q is truly the success parameter for mirrors--widely discussed but not succinctly specified as to required value. The problem is that Q can be treated as a subjective parameter--there are many milestone Qs; for scientific demonstration, for breakeven power, etc. Yet for a successful reactor, there is only one Q and that is the Q which produces mirror fusion power at the busbar that is less than the cost of delivered power in mills/kwhr by other means. We call this Q/sub PRACTICAL/ and believe there is a convincing argument that says this Q/sub PRACTICAL/ can be about 5.0 even assuming modest efficiencies for system components. A direct convertor is necessary. If the direct convertor were deleted, a Q/sub PRACTICAL/ of approximately 7.5 would be required. If we wish to soften the value of Q further, then the technical logic for the fusion fission hybrid is very powerful. With the hybrid a Q/sub PRACTICAL/ of 1.5 to 2.0 appears to be a very reasonable value. The key in being able to specify values of Q/sub PRACTICAL/ lies in economically comparing the capital cost of fusion power to the sum of the capital cost and the present value of all the fuel costs for the competitive fuel intensive plants

  19. Weyl q-coefficients for uq(3) and Racah q -coefficients for suq(2)

    International Nuclear Information System (INIS)

    Asherova, R.M.; Smirnov, Yu.F.; Tolstoy, V.N.

    1996-01-01

    With the aid of the projection-operator technique, the general analytic expression for the elements of the matrix that relates the U and T bases of an arbitrary finite-dimensional irreducible representation of the uq(3) quantum algebra (Weyl q-coefficients) is obtained for the case where the deformation parameter q is not equal to a square root of unity. The procedure for resummation of q-factorial expressions is used to prove that, modulo phase factors, these Weyl q-coefficients coincide with Racah q-coefficients for the suq(2) quantum algebra. It is also shown that, on the basis of one general formula, the q-analogs of all known general analytic expressions for the 6j symbols (and Racah coefficients) of the Lie algebras of the angular momentum can be obtained by using this resummation procedure. The symmetry properties of these q coefficients are discussed. The result is formulated in the following way: the general formulas for the q-6j symbols (Racah q-coefficients) of the suq(2) quantum algebra are obtained from the general formulas for the conventional 6j symbols (Racah coefficients) of the su(2) Lie algebra by replacing directly all factorials with q-factorials, the symmetry properties of the q-6j symbols being completely coincident with the symmetry properties of the conventional 6j symbols

  20. Bose-Einstein correlation and Q-υKυ(Q) distribution

    International Nuclear Information System (INIS)

    Dai Qirun; Zhao Shusong

    1995-01-01

    Bose-Einstein correlation is one of the most useful means to study the source emitting hadrons. Based on the non-perturbative theory of quantum fields, we have proposed a kind of source distribution, i.e., the Q -υ K υ (Q) distribution, which is applied to calculate single inclusion distribution of P // , P perpecular , N, Y and the correlation with each other, i.e., Seagull effect. The results have a better approximation to the corresponding experimental data. The paper emphasizes the calculation of Bose-Einstein correlation for inclusive two particle based on the Q -υ K υ (Q) distribution. The fitted curves agree with experimental data, especially, in the small Q range. The Q -υ K υ (Q) distribution is a more advanced theory as compared with Gauss source and K-P source distribution

  1. Die soeke na die betekenis van Q: Inleidende opmerkings oor die geskiedenis van Q-navorsing

    Directory of Open Access Journals (Sweden)

    Gerhard Nel

    2003-10-01

    According to the two source-theory, large parts of the material in Matthew and Luke which show conformity and which are not found in Mark, point to the existence of a source which comprises sayings of Jesus and reminds one of the typical wisdom material in the Old Testament. In this paper a few introductory remarks are made on the history of the research done in respect of this source, known as Q. The questions regarding the actual existence and origin of Q are briefly discussed in the first part of the paper. Four aspects of Q research are addressed: Q is a document which shows its own integrity; the distinction between tradition and redaction in Q; stratifications and phases in the development of Q; the wisdom character of the material in Q.

  2. Production of Q2Q-bar2 mesoniums in γγ reactions, hardonic collisions, and J/psi radiative decays

    International Nuclear Information System (INIS)

    Liu, K.F.

    1985-01-01

    The rho 0 rho 0 enhancement and the rho + rho - supression in γγ reactions near the threshold is taken as a strong evidence for an exotic isotensor quantum number which signals for the multi-quark (Q 2 Q-bar 2 ) structure. The mass and the cross sections agree well with the prediction based on the Q 2 Q-bar 2 structure. The 2 ++ phiphi resonance at 2.16 GeV in πp and pp collisions has been interpreted as a 2 ++ s 2 s-bar 2 mesonium. The calculated mass, width, and the cross sections are all in accord with the experimental data. The correlated J/psi pair produced around 7 GeV in πN collisions at 150 and 280 GeV/c has been considered as a 2 ++ c 2 c-bar 2 mesonium. The calculated cross sections and the longitudinal and transverse momentum distributions are consistent with the data. The calculated branching ratio for J/psi → γ(Q 2 Q-bar 2 ) 2 ++ → γ rho - rho 0 is compatible with the recent experimental upper limit and the ratios of the helicity amplitudes are distinct from the ones measured in J/psi → γ θ(1700) → γ etaeta, γ KK-bar. The branching ratio for J/γ → γ(s 2 s-bar 2 ) 2 ++ → γ phiphi is predicted to be --10 -6

  3. Solving (1,q) KdV gravity

    International Nuclear Information System (INIS)

    Montano, D.; Rivlis, G.

    1991-01-01

    In this paper we explicitly compute the correlation functions of the (1, q) series of the KdV hierarchy, i.e. models with q-1 primary fields. We also find from algebraic considerations a ghost number conservation law for the (1, q) models. All the results in this paper follow from the algebraic properties of the KdV hierarchy without using any extraneous information from a field theory interpretation. We find the interesting result that some correlation functions vanish even when they conserve ghost number. This is an indication for further selection rules. (orig.)

  4. The Q sort theory and technique.

    Science.gov (United States)

    Nyatanga, L

    1989-10-01

    This paper is based on the author's experience of using the Q sort technique with BA Social Sciences (BASS) students, and the community psychiatric nursing (CPN, ENB No 811 course). The paper focuses on two main issues: 1. The theoretical assumptions underpinning the Q Sort technique. Carl Rogers' self theory and some of the values of humanistic psychology are summarised. 2. The actual technique procedure and meaning of results are highlighted. As the Q Sort technique is potentially useful in a variety of sittings some of which are listed in this paper, the emphasis has deliberately been placed in understanding the theoretical underpinning and the operationalisation (sensitive interpretation) of the theory to practice.

  5. A q-deformed Lorentz algebra

    International Nuclear Information System (INIS)

    Schmidke, W.B.; Wess, J.; Muenchen Univ.; Zumino, B.; Lawrence Berkeley Lab., CA

    1991-01-01

    We derive a q-deformed version of the Lorentz algebra by deformating the algebra SL(2, C). The method is based on linear representations of the algebra on the complex quantum spinor space. We find that the generators usually identified with SL q (2, C) generate SU q (2) only. Four additional generators are added which generate Lorentz boosts. The full algebra of all seven generators and their coproduct is presented. We show that in the limit q→1 the generators are those of the classical Lorentz algebra plus an additional U(1). Thus we have a deformation of SL(2, C)xU(1). (orig.)

  6. Improved double Q2 rescaling model

    International Nuclear Information System (INIS)

    Gao Yonghua

    2001-01-01

    The authors present an improved double Q 2 rescaling model. Based on this condition of the nuclear momentum conservation, the authors have found a Q 2 rescaling parameters' formula of the model, where authors have established the connection between the Q 2 rescaling parameter ζ i (i = v, s, g) and the mean binding energy in nucleus. By using this model, the authors coned explain the experimental data of the EMC effect in the whole x region, the nuclear Drell-Yan process and J/Ψ photoproduction process

  7. Thermal Loss in High-Q Antennas

    DEFF Research Database (Denmark)

    Barrio, Samantha Caporal Del; Bahramzy, Pevand; Svendsen, Simon

    2014-01-01

    Tunable antennas are very promising for future generations of mobile communications, where antennas are required to cover a wide range operating bands. This letter aims at characterizing the loss mechanism of tunable antennas. Tunable antennas typically exhibit a high Quality factor (Q), which ca...... lead to thermal loss due to the conductivity of the metal. The investigation shows that copper loss is non-negligible for high Q values. In the proposed design the copper loss is 2 dB, for a Q of 260 at 700 MHz....

  8. Quantum Dilogarithms and Partition q-Series

    Science.gov (United States)

    Kato, Akishi; Terashima, Yuji

    2015-08-01

    In our previous work (Kato and Terashima, Commun Math Phys. arXiv:1403.6569, 2014), we introduced the partition q-series for mutation loop γ—a loop in exchange quiver. In this paper, we show that for a certain class of mutation sequences, called reddening sequences, the graded version of partition q-series essentially coincides with the ordered product of quantum dilogarithm associated with each mutation; the partition q-series provides a state-sum description of combinatorial Donaldson-Thomas invariants introduced by Keller.

  9. KFM 01A. Q-logging

    International Nuclear Information System (INIS)

    Barton, Nick

    2003-03-01

    The first Forsmark potential repository site borehole KFM 01A provided core from 101.8 to 1000.7 m depth. This was independently Q-logged during a two-day period (19th-20th February, 2003), without access to BORMAP results or regional jointing frequencies or orientations. The Q-logging was intended to be an independent check for subsequent BORMAP-derived Q-parameter estimation. The Q-logging was accomplished using the manually-recorded 'histogram method' which allows the logger to enter Q-parameter ranges and depths directly into the appropriate histograms, which facilitates subsequent data processing using Excel spreadsheets. Successive pairs of core boxes, which contain an average of 11 meters of core in ten rows, were the source of ten opinions of each of the six Q-parameters, giving a total of 4920 recordings of Q-parameter values for the 164 core boxes. Data processing was divided into several parts, with successively increasing detail. The report therefore contains Q-histograms for the whole core, for four identified fracture(d) zones combined as if one unit, and then for the whole core minus these fracture(d) zones. This background rock mass quality is subsequently divided into nine depth zones or slices, and trends of variation with depth are tabulated. The four identified fracture(d) zones, which are actually of reasonable quality, are also analysed separately, and similarities and subtle differences are discerned between them. The overall quality of this first core is very good to excellent, with Q(mean) of 48.4, and a most frequent Q-value of 100. The range of quality is from 2.1 to 2130, which is the complete upper half of the six order of magnitude Q scale. Even the relatively fracture(d) zones, representing some 13% of the 900 m cored, have a combined Q(mean) of 13.9 and a range of quality of 2.1 to 150

  10. Using Q Method in Qualitative Research

    Directory of Open Access Journals (Sweden)

    Pnina Shinebourne PhD

    2009-03-01

    Full Text Available In this paper the author outlines the features of Q method and assesses its suitability as a qualitative research method. She discusses the process of using the method and its particular approach to researching the range and diversity of subjective understandings, beliefs, and experiences. Q method is particularly suitable for identifying commonality and diversity and has a powerful capacity for thematic identification and analysis. In the author's view, Q method makes a contribution to expanding the repertoire of qualitative research methods.

  11. Combination of CO2 and Q-switched Nd:YAG lasers is more effective than Q-switched Nd:YAG laser alone for eyebrow tattoo removal.

    Science.gov (United States)

    Radmanesh, Mohammad; Rafiei, Zohreh

    2015-04-01

    The eyebrow tattoo removal using Q-switched lasers is usually prolonged. Other modalities may be required to enhance the efficacy and shorten the treatment course. To compare the efficacy of Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser alone versus combination of Q-switched Nd:YAG and Ultrapulse CO2 lasers for eyebrow tattoo removal after a single session. After local anesthesia, the right eyebrow of 20 patients was treated with Ultrapulse CO2 laser with the parameters of 4 J/cm(2) and 3.2 J/cm(2) for the first and the second passes. Both eyebrows were then treated with 1064-nm and 532-nm Q-switched Nd:YAG laser. The spot size and pulse duration were 3 mm and 5 nanoseconds for both wavelengths, and the fluence was 7 J/cm(2) for 1064 nm and 3 J/cm (2) for 532 nm. The side treated with combination of Q-switched Nd:YAG and CO2 lasers improved 75-100% in 6 of 20 patients versus only 1 of 20 in the side treated with Q-switched Nd:YAG alone. Similarly, the right side in 13 of 20 patients showed more than 50% improvement with combination therapy versus the left side (the monotherapy side), where only 6 of 20 cases showed more than 50% improvement. The Mann-Whitney test was 2.85 for the right side and 1.95 for the left side (P value = 0.007). Using Ultra pulse CO2 laser enhances the efficacy of Q-switched Nd:YAG laser in eyebrow tattoo removal.

  12. Free radical scavenging activity of coenzyme Q measured by a chemiluminescent assay

    International Nuclear Information System (INIS)

    Battino, Maurizio; Ferri, Elida; Girotti, Stefano; Lenaz, Giorgio

    1991-01-01

    Involvement of coenzyme Q (CoQ) in anti-oxydant activities, in addition to its major redox role, has frequently been suggested in recent years. In order to elucidate if CoQ could really be engaged in scavenging free radicals produced endogenously in a biological system, an experimental system was developed in which beef heart mitochondria in the presence of a saturating NADH concentration and of rotenone produce free radicals. The presence of oxygen-reactive forms was easily detected by a luminol-dependent chemiluminescence process. The chemi-luminescence assay showed that short-chain CoQ homologues can act as pro-oxidants, enhancing free radical effects, while exogenous coenzyme Q 10 could scavenge free radicals, especially at very low concentration. In this system, exogenous CoQ 10 was more effective than α-tocopherol at the same concentration in scavenging free radicals. The molecular mechanism that leads to this activity is still unclear, but these results are of biochemical importance because they indicate that CoQ may act as an anti=oxidant in situations mimicking physiopathological conditions. This direct chemiluminescent method is promising for studies of biochemical processes which involve active oxygen species. (author). 24 refs.; 4 figs

  13. Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC

    Science.gov (United States)

    Tai, Lee-Hwa; Goulet, Marie-Line; Belanger, Simon; Toyama-Sorimachi, Noriko; Fodil-Cornu, Nassima; Vidal, Silvia M.; Troke, Angela D.; McVicar, Daniel W.; Makrigiannis, Andrew P.

    2008-01-01

    Plasmacytoid dendritic cells (pDCs) are an important source of type I interferon (IFN) during initial immune responses to viral infections. In mice, pDCs are uniquely characterized by high-level expression of Ly49Q, a C-type lectin-like receptor specific for class I major histocompatibility complex (MHC) molecules. Despite having a cytoplasmic immunoreceptor tyrosine-based inhibitory motif, Ly49Q was found to enhance pDC function in vitro, as pDC cytokine production in response to the Toll-like receptor (TLR) 9 agonist CpG-oligonucleotide (ODN) could be blocked using soluble monoclonal antibody (mAb) to Ly49Q or H-2Kb. Conversely, CpG-ODN–dependent IFN-α production by pDCs was greatly augmented upon receptor cross-linking using immobilized anti-Ly49Q mAb or recombinant H-2Kb ligand. Accordingly, Ly49Q-deficient pDCs displayed a severely reduced capacity to produce cytokines in response to TLR7 and TLR9 stimulation both in vitro and in vivo. Finally, TLR9-dependent antiviral responses were compromised in Ly49Q-null mice infected with mouse cytomegalovirus. Thus, class I MHC recognition by Ly49Q on pDCs is necessary for optimal activation of innate immune responses in vivo. PMID:19075287

  14. Study of structural and optical properties of ZnAlQ5 (zinc aluminum quinolate) organic phosphor for OLED applications

    Science.gov (United States)

    Nagpure, I. M.; Painuly, Deepshikha; Rabanal, Maria Eugenia

    2016-05-01

    The various composition of ZnAlQ5 such as Zn1.5A10.5Q5, Zn1Al1Q5, Zn0.5Al1.5Q5 organic phosphors were prepared via simple cost effective co-precipitation method. The FTIR, SEM, photoluminescence analysis of the prepared phosphors were reported. ZnQ2 and AlQ3 were also prepared by similar method and their properties were compared with different composition of ZnAlQ5. The structural elucidation in the form of stretching frequencies of chemical bonds of the prepared phosphor was carried out using Fourier Transform Infrared Spectroscopy (FTIR). The stretching frequency analysis confirms the formation of prepared phosphor materials. The SEM analysis shows the surface morphological behavior of prepared phosphor materials. Greenish photoluminescence were observed at 505 to 510 nm for the different composition of ZnAlQ5,in which Zn1.5Al0.5Q5 shows maximum luminescence intensity at 505 nm. PL emission of ZnQ2 was observed at 515 nm, while for AlQ3 at 520 nm. The blue shift of 10 nm was observed in Zn1.5A10.5Q5 due to modification of energy level due to presence of Zn2+ and Al3+. The enhancement in PL intensity was observed in Zn1.5A10.5Q5 compared to the other composition due to transfer of energy between Zn2+ and quinolate complex. Optical properties of the prepared materials were evaluated for possible applications in organic light emitting devices (OLED).

  15. A thioredoxin-dependent peroxiredoxin Q from Corynebacterium glutamicum plays an important role in defense against oxidative stress.

    Directory of Open Access Journals (Sweden)

    Tao Su

    Full Text Available Peroxiredoxin Q (PrxQ that belonged to the cysteine-based peroxidases has long been identified in numerous bacteria, but the information on the physiological and biochemical functions of PrxQ remain largely lacking in Corynebacterium glutamicum. To better systematically understand PrxQ, we reported that PrxQ from model and important industrial organism C. glutamicum, encoded by the gene ncgl2403 annotated as a putative PrxQ, played important roles in adverse stress resistance. The lack of C. glutamicum prxQ gene resulted in enhanced cell sensitivity, increased ROS accumulation, and elevated protein carbonylation levels under adverse stress conditions. Accordingly, PrxQ-mediated resistance to adverse stresses mainly relied on the degradation of ROS. The physiological roles of PrxQ in resistance to adverse stresses were corroborated by its induced expression under adverse stresses, regulated directly by the stress-responsive ECF-sigma factor SigH. Through catalytical kinetic activity, heterodimer formation, and bacterial two-hybrid analysis, we proved that C. glutamicum PrxQ catalytically eliminated peroxides by exclusively receiving electrons from thioredoxin (Trx/thioredoxin reductase (TrxR system and had a broad range of oxidizing substrates, but a better efficiency for peroxynitrite and cumene hydroperoxide (CHP. Site-directed mutagenesis confirmed that the conserved Cys49 and Cys54 are the peroxide oxidation site and the resolving Cys residue, respectively. It was also discovered that C. glutamicum PrxQ mainly existed in monomer whether under its native state or functional state. Based on these results, a catalytic model of PrxQ is being proposed. Moreover, our result that C. glutamicum PrxQ can prevent the damaging effects of adverse stresses by acting as thioredoxin-dependent monomeric peroxidase could be further applied to improve the survival ability and robustness of the important bacterium during fermentation process.

  16. Skeletonized wave-equation inversion for Q

    KAUST Repository

    Dutta, Gaurav

    2016-09-06

    A wave-equation gradient optimization method is presented that inverts for the subsurface Q distribution by minimizing a skeletonized misfit function ε. Here, ε is the sum of the squared differences between the observed and the predicted peak/centroid frequency shifts of the early-arrivals. The gradient is computed by migrating the observed traces weighted by the frequency-shift residuals. The background Q model is perturbed until the predicted and the observed traces have the same peak frequencies or the same centroid frequencies. Numerical tests show that an improved accuracy of the inverted Q model by wave-equation Q tomography (WQ) leads to a noticeable improvement in the migration image quality.

  17. Differential calculus for q-deformed twistors

    International Nuclear Information System (INIS)

    Akulov, V.P.; Duplij, S.A.; Chitov, V.V.

    1998-01-01

    Brief type of q-deformed differential calculus at light cone with using of twistor representation is suggested. Commutative relations between coordinates and moments are obtained. Considered quasiclassical limit gives exact form of vanish from mass shell

  18. Environmental Chemistry Methods (ECM) Index - Q

    Science.gov (United States)

    Laboratories use testing methods to identify pesticides in water and soil. Environmental chemistry methods test soil and water samples to determine the fate of pesticides in the environment. Find methods for chemicals with Q as the first character.

  19. q-Gamow states for intermediate energies

    Energy Technology Data Exchange (ETDEWEB)

    Plastino, A. [La Plata National University and Argentina' s National Research Council, (IFLP-CCT-CONICET)-C. C. 727, 1900 La Plata (Argentina); Rocca, M.C., E-mail: mariocarlosrocca@gmail.com [La Plata National University and Argentina' s National Research Council, (IFLP-CCT-CONICET)-C. C. 727, 1900 La Plata (Argentina); Ferri, G.L. [Fac. de C. Exactas, National University La Pampa, Peru y Uruguay, Santa Rosa, La Pampa (Argentina); Zamora, D.J. [La Plata National University and Argentina' s National Research Council, (IFLP-CCT-CONICET)-C. C. 727, 1900 La Plata (Argentina)

    2016-11-15

    In a recent paper Plastino and Rocca (2016) [18] we have demonstrated the possible existence of Tsallis' q-Gamow states. Now, accelerators' experimental evidence for Tsallis' distributions has been ascertained only at very high energies. Here, instead, we develop a different set of q-Gamow states for which the associated q-Breit–Wigner distribution could easily be found at intermediate energies, for which accelerators are available at many locations. In this context, it should be strongly emphasized Vignat and Plastino (2009) [2] that, empirically, one never exactly and unambiguously “detects” pure Gaussians, but rather q-Gaussians. A prediction is made via Eq. (3.4).

  20. Skeletonized wave-equation inversion for Q

    KAUST Repository

    Dutta, Gaurav; Schuster, Gerard T.

    2016-01-01

    A wave-equation gradient optimization method is presented that inverts for the subsurface Q distribution by minimizing a skeletonized misfit function ε. Here, ε is the sum of the squared differences between the observed and the predicted peak/centroid frequency shifts of the early-arrivals. The gradient is computed by migrating the observed traces weighted by the frequency-shift residuals. The background Q model is perturbed until the predicted and the observed traces have the same peak frequencies or the same centroid frequencies. Numerical tests show that an improved accuracy of the inverted Q model by wave-equation Q tomography (WQ) leads to a noticeable improvement in the migration image quality.

  1. Chromosome 10q tetrasomy: First reported case

    Energy Technology Data Exchange (ETDEWEB)

    Blackston, R.D.; May, K.M.; Jones, F.D. [Emory Univ., Atlanta, GA (United States)] [and others

    1994-09-01

    While there are several reports of trisomy 10q (at least 35), we are not aware of previous cases of 10q tetrasomy. We present what we believe to be the initial report of such a case. R.J. is a 6 1/2 year old white male who presented with multiple dysmorphic features, marked articulation problems, hyperactivity, and developmental delays. He is the product of a term uncomplicated pregnancy. There was a normal spontaneous vaginal delivery with a birth weight of 6 lbs. 4oz. and length was 19 1/2 inch. Dysmorphic features include small size, an asymmetrically small head, low set ears with overfolded helixes, bilateral ptosis, downslanting eyes, right eye esotropia, prominent nose, asymmetric facies, high palate, mild pectus excavatum deformity of chest, and hyperextensible elbow joints. The patient is in special needs classes for mildly mentally handicapped students. Chromosome analysis at a resolution of 800 bands revealed a complex rearrangement of chromosomes 10 and 11. The segment 10q25.3 to q16.3 appears to be inverted and duplicated within the long arm of chromosome 10 at band q25.3 and the same segment of chromosome 10 is present on the terminal end of the short arm of chromosome 11. There is no visible loss of material from chromosome 11. Fluorescence in situ hybridization was performed with a chromosome 10 specific {open_quotes}paint{close_quotes} to confirm that all of the material on the abnormal 10 and the material on the terminal short arm of 11 was from chromosome 10. Thus, it appears that the segment 10q25.3 to q26.3 is present in four copies. Parental chromosome studies are normal. We compared findings which differ in that the case of 10q tetrasomy did not have prenatal growth deficiency, microphthalmia, cleft palate, digital anomalies, heart, or renal defects. Whereas most cases of 10q trisomy are said to have severe mental deficiency, our case of 10q tetrasomy was only mildly delayed. We report this first apparent cited case of 10q tetrasomy.

  2. Q4 生理学

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Q42 2005062285共聚焦激光扫描显微镜技术在研究大鼠海马神经元胞内钙超载中的应用=Application of confocal laser scanning microscopy on study calcium overload in rat hippocampal neurons;Q42 2005062286N型钙通道与疼痛=Involvement of N-type calcium channels in pain and antinociception;……

  3. Síndrome 18 q -heredado

    Directory of Open Access Journals (Sweden)

    Manuela Herrera Martínez

    1997-08-01

    Full Text Available Se presenta el hallazgo de una monosomía 18q-heredada por translocación materna (3q, 18q, en un niño de 4 años de edad con las características clínicas típicas, que presenta retraso mental y patrón dismórfico facial. Se realizó la correlación fenotipo-cariotipo, y el árbol genealógico de la familia. Se comparan los hallazgos del paciente con otros informados en la literatura médica y se enfatiza en el interés genético del estudio clínico y citogenético de los padres.It is presented the finding of an 18q-monosomy inherited by maternal translocation (3q, 18q in a 4-year-old boy with the typical clinical characteristics, that is, mental retardation and facial dysmorphia pattern. The phenotype-karyotype correlation and the pedigree were made. The patient's findings are compared with others reported in the medical literature, and the genetical interest of the clinical and cytogenetic study of the parents is emphasized.

  4. Local-area-enhanced, 2.5-meter resolution natural-color and color-infrared satellite-image mosaics of the Takhar mineral district in Afghanistan: Chapter Q in Local-area-enhanced, high-resolution natural-color and color-infrared satellite-image mosaics of mineral districts in Afghanistan

    Science.gov (United States)

    Davis, Philip A.; Cagney, Laura E.

    2013-01-01

    The U.S. Geological Survey (USGS), in cooperation with the U.S. Department of Defense Task Force for Business and Stability Operations, prepared databases for mineral-resource target areas in Afghanistan. The purpose of the databases is to (1) provide useful data to ground-survey crews for use in performing detailed assessments of the areas and (2) provide useful information to private investors who are considering investment in a particular area for development of its natural resources. The set of satellite-image mosaics provided in this Data Series (DS) is one such database. Although airborne digital color-infrared imagery was acquired for parts of Afghanistan in 2006, the image data have radiometric variations that preclude their use in creating a consistent image mosaic for geologic analysis. Consequently, image mosaics were created using ALOS (Advanced Land Observation Satellite; renamed Daichi) satellite images, whose radiometry has been well determined (Saunier, 2007a,b). This part of the DS consists of the locally enhanced ALOS image mosaics for the Takhar mineral district, which has industrial evaporite deposits. ALOS was launched on January 24, 2006, and provides multispectral images from the AVNIR (Advanced Visible and Near-Infrared Radiometer) sensor in blue (420–500 nanometer, nm), green (520–600 nm), red (610–690 nm), and near-infrared (760–890 nm) wavelength bands with an 8-bit dynamic range and a 10-meter (m) ground resolution. The satellite also provides a panchromatic band image from the PRISM (Panchromatic Remote-sensing Instrument for Stereo Mapping) sensor (520–770 nm) with the same dynamic range but a 2.5-m ground resolution. The image products in this DS incorporate copyrighted data provided by the Japan Aerospace Exploration Agency (©JAXA, 2008), but the image processing has altered the original pixel structure and all image values of the JAXA ALOS data, such that original image values cannot be recreated from this DS. As such

  5. Protection of dichlorvos induced oxidative stress and nigrostriatal neuronal death by chronic Coenzyme Q10 pretreatment

    International Nuclear Information System (INIS)

    Binukumar, BK; Gupta, Nidhi; Bal, Amanjit; Gill, Kiran Dip

    2011-01-01

    Numerous epidemiological studies have shown an association between pesticide exposure and increased risk of developing Parkinson's diseases. Oxidative stress generated as a result of mitochondrial dysfunction has been implicated as an important factor in the etiology of Parkinson's disease. Previously, we reported that chronic dichlorvos exposure causes mitochondrial impairments and nigrostriatal neuronal death in rats. The present study was designed to test whether Coenzyme Q 10 (CoQ 10 ) administration has any neuroprotective effect against dichlorvos mediated nigrostriatal neuronal death, α-synuclein aggregation, and motor dysfunction. Male albino rats were administered dichlorvos by subcutaneous injection at a dose of 2.5 mg/kg body weight over a period of 12 weeks. Results obtained there after showed that dichlorvos exposure leads to enhanced mitochondrial ROS production, α-synuclein aggregation, decreased dopamine and its metabolite levels resulting in nigrostriatal neurodegeneration. Pretreatment by Coenzyme Q 10 (4.5 mg/kg ip for 12 weeks) to dichlorvos treated animals significantly attenuated the extent of nigrostriatal neuronal damage, in terms of decreased ROS production, increased dopamine and its metabolite levels, and restoration of motor dysfunction when compared to dichlorvos treated animals. Thus, the present study shows that Coenzyme Q 10 administration may attenuate dichlorvos induced nigrostriatal neurodegeneration, α-synuclein aggregation and motor dysfunction by virtue of its antioxidant action. - Highlights: → CoQ 10 administration attenuates dichlorvos induced nigrostriatal neurodegenaration. → CoQ 10 pre treatment leads to preservation of TH-IR neurons. → CoQ 10 may decrease oxidative damage and α-synuclin aggregation. → CoQ 10 treatment enhances motor function and protects rats from catalepsy.

  6. Electron removal from H and He atoms in collisions with C q+ , O q+ ions

    Science.gov (United States)

    Janev, R. K.; McDowell, M. R. C.

    1984-06-01

    Cross sections for electron capture and ionisation in collision of partially and completely stripped C q+ , N q+ and O q+ ions with hydrogen and helium atoms have been calculated at selected energies. The classical trajectory Monte Carlo method was used with a variable-charge pseudopotential to describe the interaction of the active electron with the projectile ion. A scalling relationship has been derived for the electron removal (capture and ionisation) cross section which allows a unifield representation of the data.

  7. q-Power function over q-commuting variables and deformed XXX, XXZ chains

    International Nuclear Information System (INIS)

    Khoroshkin, S.M.; Stolin, A.A.; Tolstoy, V.N.

    2001-01-01

    Certain functional identifies for the Gauss q-power function of a sum of q-commuting variables are found. Then these identifies are used to obtain two-parameter twists of the quantum affine algebra U q (sl 2 ) and of the Yangian Y(sl 2 ). The corresponding deformed trigonometric and rational quantum R matrices, which then are used in the computation of deformed XXX and XXZ Hamiltonians [ru

  8. High rates of de novo 15q11q13 inversions in human spermatozoa

    Directory of Open Access Journals (Sweden)

    Molina Òscar

    2012-02-01

    Full Text Available Abstract Low-Copy Repeats predispose the 15q11-q13 region to non-allelic homologous recombination. We have already demonstrated that a significant percentage of Prader-Willi syndrome (PWS fathers have an increased susceptibility to generate 15q11q13 deletions in spermatozoa, suggesting the participation of intrachromatid exchanges. This work has been focused on assessing the incidence of de novo 15q11q13 inversions in spermatozoa of control donors and PWS fathers in order to determine the basal rates of inversions and to confirm the intrachromatid mechanism as the main cause of 15q11q13 anomalies. Semen samples from 10 control donors and 16 PWS fathers were processed and analyzed by triple-color FISH. Three differentially labeled BAC-clones were used: one proximal and two distal of the 15q11-q13 region. Signal associations allowed the discrimination between normal and inverted haplotypes, which were confirmed by laser-scanning confocal microscopy. Two types of inversions were detected which correspond to the segments involved in Class I and II PWS deletions. No significant differences were observed in the mean frequencies of inversions between controls and PWS fathers (3.59% ± 0.46 and 9.51% ± 0.87 vs 3.06% ± 0.33 and 10.07% ± 0.74. Individual comparisons showed significant increases of inversions in four PWS fathers (P Results suggest that the incidence of heterozygous inversion carriers in the general population could reach significant values. This situation could have important implications, as they have been described as predisposing haplotypes for genomic disorders. As a whole, results confirm the high instability of the 15q11-q13 region, which is prone to different types of de novo reorganizations by intrachromatid NAHR.

  9. Integrable Equations of the Form qt=L1(x,t,q,qx,qxx)qxxx+L2(x,t,q,qx,qxx)

    International Nuclear Information System (INIS)

    Satir, Ahmet

    2003-01-01

    Integrable equations of the form q t =L 1 (x,t,q,q x ,q xx )q xxx +L 2 (x,t,q,q x ,q xx ) are considered using linearization. A new type of integrable equations which are the generalization of the integrable equations of Fokas and Ibragimov and Shabat are given

  10. Syntenic homology of human unique DNA sequences within chromossome regions 5q31, 10q22, 13q32-33 and 19q13.1 in the great apes

    Directory of Open Access Journals (Sweden)

    Rhea U. Vallente-Samonte

    2000-09-01

    Full Text Available Homologies between chromosome banding patterns and DNA sequences in the great apes and humans suggest an apparent common origin for these two lineages. The availability of DNA probes for specific regions of human chromosomes (5q31, 10q22, 13q32-33 and 19q13.1 led us to cross-hybridize these to chimpanzee (Pan troglodytes, PTR, gorilla (Gorilla gorilla, GGO and orangutan (Pongo pygmaeus, PPY chromosomes in a search for equivalent regions in the great apes. Positive hybridization signals to the chromosome 5q31-specific DNA probe were observed at HSA 5q31, PTR 4q31, GGO 4q31 and PPY 4q31, while fluorescent signals using the chromosome 10q22-specific DNA probe were noted at HSA 10q22, PTR 8q22, GGO 8q22 and PPY 7q22. The chromosome arms showing hybridization signals to the Quint-EssentialTM 13-specific DNA probe were identified as HSA 13q32-33, PTR 14q32-33, GGO 14q32-33 and PPY 14q32-33, while those presenting hybridization signals to the chromosome 19q13.1-specific DNA probe were identified as HSA 19q13.1, PTR 20q13, GGO 20q13 and PPY 20q13. All four probes presumably hybridized to homologous chromosomal locations in the apes, which suggests a homology of certain unique DNA sequences among hominoid species.Homologias entre os padrões de bandamento de cromossomos e seqüências de DNA em grandes macacos e humanos sugerem uma aparente origem comum para estas duas linhagens. A disponibilidade de sondas de DNA para regiões específicas de cromossomos humanos (5q31, 10q22, 13q32-33 e 19q13.1 nos levou a realizar hibridação cruzada com cromossomos de chimpanzé (Pan troglodytes, PTR, gorila (Gorilla gorilla, GGO e orangotango (Pongo pygmaeus, PPY em um pesquisa de regiões equivalentes em grandes macacos. Sinais positivos de hibridação para a sonda de DNA específica para o cromossomo 5q31 foram observados em HSA 5q31, PTR 4q31, GGO 4q31 e PPY 4q31, enquanto que sinais fluorescentes usando a sonda de DNA específica para o cromossomo 10q22 foram

  11. Chemical failure modes of AlQ3-based OLEDs: AlQ3 hydrolysis.

    Science.gov (United States)

    Knox, John E; Halls, Mathew D; Hratchian, Hrant P; Schlegel, H Bernhard

    2006-03-28

    Tris(8-hydroxyquinoline)aluminum(III), AlQ3, is used in organic light-emitting diodes (OLEDs) as an electron-transport material and emitting layer. The reaction of AlQ3 with trace H2O has been implicated as a major failure pathway for AlQ3-based OLEDs. Hybrid density functional calculations have been carried out to characterize the hydrolysis of AlQ3. The thermochemical and atomistic details for this important reaction are reported for both the neutral and oxidized AlQ3/AlQ3+ systems. In support of experimental conclusions, the neutral hydrolysis reaction pathway is found to be a thermally activated process, having a classical barrier height of 24.2 kcal mol(-1). First-principles infrared and electronic absorption spectra are compared to further characterize AlQ3 and the hydrolysis pathway product, AlQ2OH. The activation energy for the cationic AlQ3 hydrolysis pathway is found to be 8.5 kcal mol(-1) lower than for the neutral reaction, which is significant since it suggests a role for charge imbalance in promoting chemical failure modes in OLED devices.

  12. On alternative q-Weibull and q-extreme value distributions: Properties and applications

    Science.gov (United States)

    Zhang, Fode; Ng, Hon Keung Tony; Shi, Yimin

    2018-01-01

    Tsallis statistics and Tsallis distributions have been attracting a significant amount of research work in recent years. Importantly, the Tsallis statistics, q-distributions have been applied in different disciplines. Yet, a relationship between some existing q-Weibull distributions and q-extreme value distributions that is parallel to the well-established relationship between the conventional Weibull and extreme value distributions through a logarithmic transformation has not be established. In this paper, we proposed an alternative q-Weibull distribution that leads to a q-extreme value distribution via the q-logarithm transformation. Some important properties of the proposed q-Weibull and q-extreme value distributions are studied. Maximum likelihood and least squares estimation methods are used to estimate the parameters of q-Weibull distribution and their performances are investigated through a Monte Carlo simulation study. The methodologies and the usefulness of the proposed distributions are illustrated by fitting the 2014 traffic fatalities data from The National Highway Traffic Safety Administration.

  13. Fermi-Dirac correlation and Q-νKν(Q) distribution

    International Nuclear Information System (INIS)

    Dai Qirun; Li Jimei; Ma Zhanqing; Zhao Shusong

    1996-01-01

    The Fermi-Dirac correlation of identical protons is studied. Based on the non-perturbative theory of quantum fields, we put forward a kind of source distribution--the Q -ν K ν (Q) distribution. The Fermi-Dirac correlation of (p +- -p +- )-pairs is calculated from this distribution. The fitted curves agree with experimental data. The Q -ν K ν (Q) distribution has more advantages than the Gauss Source distribution. The radii of the source emitting hadrons and the anomalous dimensions of the Fermi field are calculated from the Fermi-Dirac correlation of identical protons

  14. Frontend event selection with an MBD using Q

    International Nuclear Information System (INIS)

    Amann, J.F.

    1981-01-01

    A problem common to many complex experiments in Nuclear Physics is the need to provide for event selection at a level beyond that readily available in a fast hardware trigger. This may be desirable as a means of reducing the amount of unwanted data going to tape, or be needed to reduce system deadtime, so as not to miss an infrequent good event. The latter criterion is particularly important at low duty factor accelerators such as LAMPF, where instantaneous trigger rates may be quite high. The need for such an event selection mechanism has arisen in conjunction with the installation of a polarimeter in the focal plane of the High Resolution Spectrometer (HRS) at LAMPF. It has been met using a combination of buffered CAMAC electronics and an enhancement to the LAMPF standard Q data acquisition system. The enhancement to Q allows the experimeter to specify at runtime, a set of simple tests to be performed on each event as it is processed by the MBD, and before it is passed to the PDP-11 for taping and further analysis

  15. A Quantitative Electrophysiological Biomarker of Duplication 15q11.2-q13.1 Syndrome.

    Directory of Open Access Journals (Sweden)

    Joel Frohlich

    Full Text Available Duplications of 15q11.2-q13.1 (Dup15q syndrome are highly penetrant for autism spectrum disorder (ASD. A distinct electrophysiological (EEG pattern characterized by excessive activity in the beta band has been noted in clinical reports. We asked whether EEG power in the beta band, as well as in other frequency bands, distinguished children with Dup15q syndrome from those with non-syndromic ASD and then examined the clinical correlates of this electrophysiological biomarker in Dup15q syndrome.In the first study, we recorded spontaneous EEG from children with Dup15q syndrome (n = 11, age-and-IQ-matched children with ASD (n = 10 and age-matched typically developing (TD children (n = 9 and computed relative power in 6 frequency bands for 9 regions of interest (ROIs. Group comparisons were made using a repeated measures analysis of variance. In the second study, we recorded spontaneous EEG from a larger cohort of individuals with Dup15q syndrome (n = 27 across two sites and examined age, epilepsy, and duplication type as predictors of beta power using simple linear regressions.In the first study, spontaneous beta1 (12-20 Hz and beta2 (20-30 Hz power were significantly higher in Dup15q syndrome compared with both comparison groups, while delta (1-4 Hz was significantly lower than both comparison groups. Effect sizes in all three frequency bands were large (|d| > 1. In the second study, we found that beta2 power was significantly related to epilepsy diagnosis in Dup15q syndrome.Here, we have identified an electrophysiological biomarker of Dup15q syndrome that may facilitate clinical stratification, treatment monitoring, and measurement of target engagement for future clinical trials. Future work will investigate the genetic and neural underpinnings of this electrophysiological signature as well as the functional consequences of excessive beta oscillations in Dup15q syndrome.

  16. Chromosome 15q24 microdeletion syndrome

    Directory of Open Access Journals (Sweden)

    Magoulas Pilar L

    2012-01-01

    Full Text Available Abstract Chromosome 15q24 microdeletion syndrome is a recently described rare microdeletion syndrome that has been reported in 19 individuals. It is characterized by growth retardation, intellectual disability, and distinct facial features including long face with high anterior hairline, hypertelorism, epicanthal folds, downslanting palpebral fissures, sparse and broad medial eyebrows, broad and/or depressed nasal bridge, small mouth, long smooth philtrum, and full lower lip. Other common findings include skeletal and digital abnormalities, genital abnormalities in males, hypotonia, behavior problems, recurrent infections, and eye problems. Other less frequent findings include hearing loss, growth hormone deficiency, hernias, and obesity. Congenital malformations, while rare, can be severe and include structural brain anomalies, cardiovascular malformations, congenital diaphragmatic hernia, intestinal atresia, imperforate anus, and myelomeningocele. Karyotypes are typically normal, and the deletions were detected in these individuals by array comparative genomic hybridization (aCGH. The deletions range in size from 1.7-6.1 Mb and usually result from nonallelic homologous recombination (NAHR between paralogous low-copy repeats (LCRs. The majority of 15q24 deletions have breakpoints that localize to one of five LCR clusters labeled LCR15q24A, -B, -C, -D, and -E. The smallest region of overlap (SRO spans a 1.2 Mb region between LCR15q24B to LCR15q24C. There are several candidate genes within the SRO, including CYP11A1, SEMA7A, CPLX3, ARID3B, STRA6, SIN3A and CSK, that may predispose to many of the clinical features observed in individuals with 15q24 deletion syndrome. The deletion occurred as a de novo event in all of the individuals when parents were available for testing. Parental aCGH and/or FISH studies are recommended to provide accurate genetic counseling and guidance regarding prognosis, recurrence risk, and reproductive options. Management

  17. Q-Thruster Breadboard Campaign Project

    Science.gov (United States)

    White, Harold

    2014-01-01

    Dr. Harold "Sonny" White has developed the physics theory basis for utilizing the quantum vacuum to produce thrust. The engineering implementation of the theory is known as Q-thrusters. During FY13, three test campaigns were conducted that conclusively demonstrated tangible evidence of Q-thruster physics with measurable thrust bringing the TRL up from TRL 2 to early TRL 3. This project will continue with the development of the technology to a breadboard level by leveraging the most recent NASA/industry test hardware. This project will replace the manual tuning process used in the 2013 test campaign with an automated Radio Frequency (RF) Phase Lock Loop system (precursor to flight-like implementation), and will redesign the signal ports to minimize RF leakage (improves efficiency). This project will build on the 2013 test campaign using the above improvements on the test implementation to get ready for subsequent Independent Verification and Validation testing at Glenn Research Center (GRC) and Jet Propulsion Laboratory (JPL) in FY 2015. Q-thruster technology has a much higher thrust to power than current forms of electric propulsion (7x Hall thrusters), and can significantly reduce the total power required for either Solar Electric Propulsion (SEP) or Nuclear Electric Propulsion (NEP). Also, due to the high thrust and high specific impulse, Q-thruster technology will greatly relax the specific mass requirements for in-space nuclear reactor systems. Q-thrusters can reduce transit times for a power-constrained architecture.

  18. Hamm q.q./ABN AMRO: inning van stil verpande vorderingen tijdens faillissement

    NARCIS (Netherlands)

    M.L. Tuil (Mark)

    2010-01-01

    textabstractIn deze bijdrage wordt het arrest HR 30 oktober 2009, LJN BJ0861, RvdW 2009, 1271 (Hamm q.q./ABN AMRO) besproken. Aan de orde komen de wachtperiode die voor de curator geldt op grond van het arrest ING/Verdonk, de informatieverschaffing door de curator aan de pandhouder en de kosten

  19. 29 CFR Appendix A to Subpart Q of... - References to subpart Q of Part 1926

    Science.gov (United States)

    2010-07-01

    ... ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION Concrete and Masonry Construction Pt. 1926, Subpt. Q, App. A Appendix A to Subpart Q of Part 1926—References to subpart.... • Accident Prevention Manual for Industrial Operations; Eighth Edition; National Safety Council. • Building...

  20. Maths-type q-deformed coherent states for q>1

    International Nuclear Information System (INIS)

    Quesne, C.; Penson, K.A.; Tkachuk, V.M.

    2003-01-01

    Maths-type q-deformed coherent states with q>1 allow a resolution of unity in the form of an ordinary integral. They are sub-Poissonian and squeezed. They may be associated with a harmonic oscillator with minimal uncertainties in both position and momentum and are intelligent coherent states for the corresponding deformed Heisenberg algebra

  1. Maternally Derived Microduplications at 15q11-q13: Implication of Imprinted Genes in Psychotic Illness

    DEFF Research Database (Denmark)

    Ingason, Andrés; Kirov, George; Giegling, Ina

    2011-01-01

    or schizoaffective disorder and 41,370 comparison subjects without known psychiatric illness for copy number variants at 15q11-q13 and determined the parental origin of duplications using methylation-sensitive Southern hybridization analysis. Results: Duplications were found in four case patients and five comparison...

  2. Microstructure development and mechanical properties of quenching and partitioning (Q and P) steel and an incorporation of hot-dipping galvanization during Q and P process

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Jing; Yu, Hao, E-mail: yhzhmr@126.com

    2013-12-01

    The “quenching and partitioning” (Q and P) process has recently been substantiated to be a unique technological route for the production of high strength steels with significant amounts of retained austenite, and thus to provide better combination of strength and ductility. In this work, intercritically annealed specimens followed by Q and P treatment have been applied to low-carbon steel with chemical composition typical for conventional TRIP-assisted steels. Microstructure of the steel treated by the Q and P process was characterized by means of optical microscope, SEM, TEM and XRD. The study suggests that microstructure is mainly composed of ferrite, lath martensite, martensite–austenite islands, retained austenite and a small amount of bainite formed during partitioning. The fraction of bainite formed during partitioning is proportional to quenching temperature. The mechanical property of specimen treated by the Q and P process exhibits an improved combination of strength and ductility than that of the Q and T process. Two schemes of hot-dipping galvanization processes were designed. The results indicate that both hot-dip galvanizing schemes present a limited reduction in tensile strength and a slight enhancement of ductility. The scheme of galvanizing and partitioning after the quenching progress shows a better combination of strength and ductility.

  3. Q-systems as cluster algebras

    International Nuclear Information System (INIS)

    Kedem, Rinat

    2008-01-01

    Q-systems first appeared in the analysis of the Bethe equations for the XXX model and generalized Heisenberg spin chains (Kirillov and Reshetikhin 1987 Zap. Nauchn. Sem. Leningr. Otd. Mat. Inst. Steklov. 160 211-21, 301). Such systems are known to exist for any simple Lie algebra and many other Kac-Moody algebras. We formulate the Q-system associated with any simple, simply-laced Lie algebras g in the language of cluster algebras (Fomin and Zelevinsky 2002 J. Am. Math. Soc. 15 497-529), and discuss the relation of the polynomiality property of the solutions of the Q-system in the initial variables, which follows from the representation-theoretical interpretation, to the Laurent phenomenon in cluster algebras (Fomin and Zelevinsky 2002 Adv. Appl. Math. 28 119-44)

  4. Q methodology, risk training and quality management.

    Science.gov (United States)

    McKeown, M; Hinks, M; Stowell-Smith, M; Mercer, D; Forster, J

    1999-01-01

    The results of a Q methodological study of professional understandings of the notion of risk in mental health services within the UK are discussed in relation to the relevance for staff training and quality assurance. The study attempted to access the diversity of understandings of risk issues amongst a multi-professional group of staff (n = 60) attending inter-agency risk training workshops in 1998. Q methodology is presented as both an appropriate means for such inquiry and as a novel experiential technique for training purposes. A tentative argument is advanced that the qualitative accounts generated by Q research could assist in systematic reviews of quality, complementing the singularly quantitative approaches typically represented in the audit process.

  5. QqZ decays at Tevatron and SSC energies

    International Nuclear Information System (INIS)

    Agrawal, P.; Ellis, S.D.

    1990-09-01

    The possible existence of a new heavy quark Q that decays predominantly via the flavor changing neutral current transition QqZ is discussed. Candidates include a fourth generation charge -- 1/3 quark, or a more exotic vector-like quark. Such particles are interesting both as extensions of the Standard Model and due to their unique decay modes. The primary experimental indication of the pair production and subsequent decay of quarks is ZZ pair production at an essentially strong interaction rate. This mode can then constitute an unexpected background to the searches for other particles. In particular the channel Q bar Q → ZZ + X can generate a serious background to the search for the Higgs boson via the H 0 → ZZ mode at the SSC. Thus it is essential to search for such new heavy quarks at the Tevatron. Possible detection signatures for this purpose are discussed. 24 refs. , 1 fig., 3 tabs

  6. Electroweak gauge-boson production at small q T : Infrared safety from the collinear anomaly

    Science.gov (United States)

    Becher, Thomas; Neubert, Matthias; Wilhelm, Daniel

    2012-02-01

    Using methods from effective field theory, we develop a novel, systematic framework for the calculation of the cross sections for electroweak gauge-boson production at small and very small transverse momentum q T , in which large logarithms of the scale ratio M V /q T are resummed to all orders. These cross sections receive logarithmically enhanced corrections from two sources: the running of the hard matching coefficient and the collinear factorization anomaly. The anomaly leads to the dynamical generation of a non-perturbative scale {q_* } ˜ {M_V}{e^{ - {text{const}}/{α_s}left( {{M_V}} right)}} , which protects the processes from receiving large long-distance hadronic contributions. Expanding the cross sections in either α s or q T generates strongly divergent series, which must be resummed. As a by-product, we obtain an explicit non-perturbative expression for the intercept of the cross sections at q T = 0, including the normalization and first-order α s ( q ∗ ) correction. We perform a detailed numerical comparison of our predictions with the available data on the transverse-momentum distribution in Z-boson production at the Tevatron and LHC.

  7. Application of a Q Method Study to Understanding Nurses' Perspective of Adopting Evidence-Based Nursing

    Directory of Open Access Journals (Sweden)

    Ruo-Nan Jueng, Ph.D., RN

    2017-12-01

    Full Text Available s u m m a r y: Purpose: This study applied the Q method to identify and describe the various types of nurse perceptions that are crucially associated with their engagement in evidence-based nursing (EBN. Methods: The study participants were nurses at a medical center and a regional teaching hospital. A series of Q sorts was performed by nurses to subjectively rank the Q statements. Q statements were constructed based on the literature related to EBN adoption by nurses and face-to-face interviews. Results: A total of 60 participants were invited to rank 44 Q statements related to EBN. Factor analysis was conducted on the rankings of the Q statements. The following are the five prominent shared perspectives: (1 emphasized the obstacles to evidence searching and reading ability; (2 emphasized the organizational promotive strategies; (3 emphasized the available supportive resources; (4 emphasized the significance of EBN; and (5 emphasized the evidence-searching ability and external incentives. The five identified groups of perspectives can enhance hospital administrators to acknowledge the barriers and incentives associated with EBN practices. Conclusion: The exploration of clustering nurses' perceptions may facilitate the development of customized strategies to enable more appropriate training. Keywords: clinical competence, evidence-based nursing, methods, nursing care

  8. Measuring and weighing psychostasia in Q 6:37–38: Intertexts from the Old Testament

    Directory of Open Access Journals (Sweden)

    Llewellyn Howes

    2014-02-01

    Full Text Available This article is the first of three on the relationship between the Sayings Gospel Q and the ancient concept of ‘psychostasia,’ which is the ancient notion that a divine or supernatural figure weighed people’s souls when judging them. The ultimate goal of all three articles is to enhance our understanding of Q 6:37–38, as well as of the Q document as a whole. In the current article, attention is focused on intertexts from the Old Testament, and the occurrences therein of the word ‘measure’ and the concept of ‘psychostasia’. The implications of these results for our interpretation of Q 6:37–38 are briefly noted. A second (future article will focus on intertexts in apocryphal and pseudepigraphical writings from Second Temple Judaism dealing with ‘psychostasia’. A third study will ultimately spell out in more comprehensive detail the implications of the foregoing intertextual investigations on both our understanding of Q 6:37–38 and our understanding of the Sayings Gospel Q as a whole.

  9. Calcium binding and transport by coenzyme Q.

    Science.gov (United States)

    Bogeski, Ivan; Gulaboski, Rubin; Kappl, Reinhard; Mirceski, Valentin; Stefova, Marina; Petreska, Jasmina; Hoth, Markus

    2011-06-22

    Coenzyme Q10 (CoQ10) is one of the essential components of the mitochondrial electron-transport chain (ETC) with the primary function to transfer electrons along and protons across the inner mitochondrial membrane (IMM). The concomitant proton gradient across the IMM is essential for the process of oxidative phosphorylation and consequently ATP production. Cytochrome P450 (CYP450) monoxygenase enzymes are known to induce structural changes in a variety of compounds and are expressed in the IMM. However, it is unknown if CYP450 interacts with CoQ10 and how such an interaction would affect mitochondrial function. Using voltammetry, UV-vis spectrometry, electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR), fluorescence microscopy and high performance liquid chromatography-mass spectrometry (HPLC-MS), we show that both CoQ10 and its analogue CoQ1, when exposed to CYP450 or alkaline media, undergo structural changes through a complex reaction pathway and form quinone structures with distinct properties. Hereby, one or both methoxy groups at positions 2 and 3 on the quinone ring are replaced by hydroxyl groups in a time-dependent manner. In comparison with the native forms, the electrochemically reduced forms of the new hydroxylated CoQs have higher antioxidative potential and are also now able to bind and transport Ca(2+) across artificial biomimetic membranes. Our results open new perspectives on the physiological importance of CoQ10 and its analogues, not only as electron and proton transporters, but also as potential regulators of mitochondrial Ca(2+) and redox homeostasis.

  10. Harmonic Analysis Associated with the Generalized q-Bessel Operator

    Directory of Open Access Journals (Sweden)

    Ahmed Abouelaz

    2016-01-01

    Full Text Available In this article, we give a new harmonic analysis associated with the generalized q-Bessel operator. We introduce the generalized $q$-Bessel transform, the generalized q-Bessel translation and the generalized $q$-Bessel convolution product.

  11. Chemistry and Molecular Dynamics Simulations of Heme b-HemQ and Coproheme-HemQ.

    Science.gov (United States)

    Hofbauer, Stefan; Dalla Sega, Marco; Scheiblbrandner, Stefan; Jandova, Zuzana; Schaffner, Irene; Mlynek, Georg; Djinović-Carugo, Kristina; Battistuzzi, Gianantonio; Furtmüller, Paul G; Oostenbrink, Chris; Obinger, Christian

    2016-09-27

    Recently, a novel pathway for heme b biosynthesis in Gram-positive bacteria has been proposed. The final poorly understood step is catalyzed by an enzyme called HemQ and includes two decarboxylation reactions leading from coproheme to heme b. Coproheme has been suggested to act as both substrate and redox active cofactor in this reaction. In the study presented here, we focus on HemQs from Listeria monocytogenes (LmHemQ) and Staphylococcus aureus (SaHemQ) recombinantly produced as apoproteins in Escherichia coli. We demonstrate the rapid and two-phase uptake of coproheme by both apo forms and the significant differences in thermal stability of the apo forms, coproheme-HemQ and heme b-HemQ. Reduction of ferric high-spin coproheme-HemQ to the ferrous form is shown to be enthalpically favored but entropically disfavored with standard reduction potentials of -205 ± 3 mV for LmHemQ and -207 ± 3 mV for SaHemQ versus the standard hydrogen electrode at pH 7.0. Redox thermodynamics suggests the presence of a pronounced H-bonding network and restricted solvent mobility in the heme cavity. Binding of cyanide to the sixth coproheme position is monophasic but relatively slow (∼1 × 10(4) M(-1) s(-1)). On the basis of the available structures of apo-HemQ and modeling of both loaded forms, molecular dynamics simulation allowed analysis of the interaction of coproheme and heme b with the protein as well as the role of the flexibility at the proximal heme cavity and the substrate access channel for coproheme binding and heme b release. Obtained data are discussed with respect to the proposed function of HemQ in monoderm bacteria.

  12. Distinctive phenotype in 9 patients with deletion of chromosome 1q24-q25.

    Science.gov (United States)

    Burkardt, Deepika D'Cunha; Rosenfeld, Jill A; Helgeson, Maria L; Angle, Brad; Banks, Valerie; Smith, Wendy E; Gripp, Karen W; Moline, Jessica; Moran, Rocio T; Niyazov, Dmitriy M; Stevens, Cathy A; Zackai, Elaine; Lebel, Robert Roger; Ashley, Douglas G; Kramer, Nancy; Lachman, Ralph S; Graham, John M

    2011-06-01

    Reports of individuals with deletions of 1q24→q25 share common features of prenatal onset growth deficiency, microcephaly, small hands and feet, dysmorphic face and severe cognitive deficits. We report nine individuals with 1q24q25 deletions, who show distinctive features of a clinically recognizable 1q24q25 microdeletion syndrome: prenatal-onset microcephaly and proportionate growth deficiency, severe cognitive disability, small hands and feet with distinctive brachydactyly, single transverse palmar flexion creases, fifth finger clinodactyly and distinctive facial features: upper eyelid fullness, small ears, short nose with bulbous nasal tip, tented upper lip, and micrognathia. Radiographs demonstrate disharmonic osseous maturation with markedly delayed bone age. Occasional features include cleft lip and/or palate, cryptorchidism, brain and spinal cord defects, and seizures. Using oligonucleotide-based array comparative genomic hybridization, we defined the critical deletion region as 1.9 Mb at 1q24.3q25.1 (chr1: 170,135,865-172,099,327, hg18 coordinates), containing 13 genes and including CENPL, which encodes centromeric protein L, a protein essential for proper kinetochore function and mitotic progression. The growth deficiency in this syndrome is similar to what is seen in other types of primordial short stature with microcephaly, such as Majewski osteodysplastic primordial dwarfism, type II (MOPD2) and Seckel syndrome, which result from loss-of-function mutations in genes coding for centrosomal proteins. DNM3 is also in the deleted region and expressed in the brain, where it participates in the Shank-Homer complex and increases synaptic strength. Therefore, DNM3 is a candidate for the cognitive disability, and CENPL is a candidate for growth deficiency in this 1q24q25 microdeletion syndrome. Copyright © 2011 Wiley-Liss, Inc.

  13. N*(1535) electroproduction at high Q2

    Energy Technology Data Exchange (ETDEWEB)

    G. Ramalho, M.T. Pena, K. Tsushima

    2012-04-01

    A covariant spectator quark model is applied to study the {gamma}N {yields} N*(1535) reaction in the large Q{sup 2} region. Starting from the relation between the nucleon and N*(1535) systems, the N*(1535) valence quark wave function is determined without the addition of any parameters. The model is then used to calculate the {gamma}N {yields} N*(1535) transition form factors. A very interesting, useful relation between the A{sub 1/2} and S{sub 1/2} helicity amplitudes for Q{sup 2} > GeV{sup 2}, is also derived.

  14. q-Virasoro constraints in matrix models

    Energy Technology Data Exchange (ETDEWEB)

    Nedelin, Anton [Dipartimento di Fisica, Università di Milano-Bicocca and INFN, sezione di Milano-Bicocca, Piazza della Scienza 3, I-20126 Milano (Italy); Department of Physics and Astronomy, Uppsala university,Box 516, SE-75120 Uppsala (Sweden); Zabzine, Maxim [Department of Physics and Astronomy, Uppsala university,Box 516, SE-75120 Uppsala (Sweden)

    2017-03-20

    The Virasoro constraints play the important role in the study of matrix models and in understanding of the relation between matrix models and CFTs. Recently the localization calculations in supersymmetric gauge theories produced new families of matrix models and we have very limited knowledge about these matrix models. We concentrate on elliptic generalization of hermitian matrix model which corresponds to calculation of partition function on S{sup 3}×S{sup 1} for vector multiplet. We derive the q-Virasoro constraints for this matrix model. We also observe some interesting algebraic properties of the q-Virasoro algebra.

  15. An improved Q estimation approach: the weighted centroid frequency shift method

    Science.gov (United States)

    Li, Jingnan; Wang, Shangxu; Yang, Dengfeng; Dong, Chunhui; Tao, Yonghui; Zhou, Yatao

    2016-06-01

    Seismic wave propagation in subsurface media suffers from absorption, which can be quantified by the quality factor Q. Accurate estimation of the Q factor is of great importance for the resolution enhancement of seismic data, precise imaging and interpretation, and reservoir prediction and characterization. The centroid frequency shift method (CFS) is currently one of the most commonly used Q estimation methods. However, for seismic data that contain noise, the accuracy and stability of Q extracted using CFS depend on the choice of frequency band. In order to reduce the influence of frequency band choices and obtain Q with greater precision and robustness, we present an improved CFS Q measurement approach—the weighted CFS method (WCFS), which incorporates a Gaussian weighting coefficient into the calculation procedure of the conventional CFS. The basic idea is to enhance the proportion of advantageous frequencies in the amplitude spectrum and reduce the weight of disadvantageous frequencies. In this novel method, we first construct a Gauss function using the centroid frequency and variance of the reference wavelet. Then we employ it as the weighting coefficient for the amplitude spectrum of the original signal. Finally, the conventional CFS is adopted for the weighted amplitude spectrum to extract the Q factor. Numerical tests of noise-free synthetic data demonstrate that the WCFS is feasible and efficient, and produces more accurate results than the conventional CFS. Tests for noisy synthetic data indicate that the new method has better anti-noise capability than the CFS. The application to field vertical seismic profile (VSP) data further demonstrates its validity5.

  16. Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinoma

    International Nuclear Information System (INIS)

    Rao, Pulivarthi H; Murty, Vundavalli VVS; Arias-Pulido, Hugo; Lu, Xin-Yan; Harris, Charles P; Vargas, Hernan; Zhang, Fang F; Narayan, Gopeshwar; Schneider, Achim; Terry, Mary Beth

    2004-01-01

    Carcinoma of uterine cervix is the second most common cancers among women worldwide. Combined radiation and chemotherapy is the choice of treatment for advanced stages of the disease. The prognosis is poor, with a five-year survival rate ranging from about 20–65%, depending on stage of the disease. Therefore, genetic characterization is essential for understanding the biology and clinical heterogeneity in cervical cancer (CC). We used a genome-wide screening method – comparative genomic hybridization (CGH) to identify DNA copy number changes in 77 patients with cervical cancer. We applied categorical and survival analyses to analyze whether chromosomal changes were related to clinico-pathologic characteristics and patients survival. The CGH analysis revealed a loss of 2q33-q37 (57.1%), gain of 3q (54.5%) and chromosomal amplifications (20.77%) as frequent genetic changes. A total of 15 amplified chromosomal sites were detected in 16 cases that include 1p31, 2q32, 7q22, 8q21.2-q24, 9p22, 10q21, 10q24, 11q13, 11q21, 12q15, 14q12, 17p11.2, 17q22, 18p11.2, and 19q13.1. Recurrent amplified sites were noted at 11q13, 11q21, and 19q13.1. The genomic alterations were further evaluated for prognostic significance in CC patients, and we did not find any correlation with a number of clinical or histological parameters. The tumors harboring HPV18 exhibited higher genomic instability compared to tumors with HPV 16. This study demonstrated that 2q33-q37 deletions, 3q gains and chromosomal amplifications as characteristic changes in invasive CC. These genetic alterations will aid in the identification of novel tumor suppressor gene(s) at 2q33-q37 and oncogenes at amplified chromosomal sites. Molecular characterization of these chromosomal changes utilizing the current genomic technologies will provide new insights into the biology and clinical behavior of CC

  17. Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training

    Directory of Open Access Journals (Sweden)

    Ragip Pala, Cemal Orhan, Mehmet Tuzcu, Nurhan Sahin, Shakir Ali, Vedat Cinar, Mustafa Atalay, Kazim Sahin

    2016-03-01

    Full Text Available This study reports the effects of Q10, coenzyme Q10 or ubiquinone, a component of the electron transport chain in mitochondria, on nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB, inhibitors of kappa B (IκB, nuclear factor (erythroid-derived 2-like 2 (Nrf2 and hemeoxygenase 1 (HO-1 in rats after chronic exercise training for 6 weeks. 8-week old male Wistar rats were assigned randomly to one of four treatments planned in a 2 x 2 factorial arrangement of two condition (sedentary vs. exercise training, and two coenzyme Q10 levels (0 and 300 mg/kg per day for 6 weeks. The expression levels of the target proteins were determined in the heart, liver and muscle, and biochemical parameters including creatinine, urea, glucose and lipid profile were investigated in plasma. When compared with sedentary group, significant decreases in heart, liver and muscle NFκB levels by 45%, 26% and 44% were observed in Q10 supplemented rats after exercise training, respectively, while the inhibitory protein IκB increased by 179%, 111% and 127% in heart, liver and muscle tissues. Q10 supplementation caused an increase in Nrf2 (167%, 165% and 90% and HO-1 (107%, 156% and 114% after exercise training in heart, liver and muscle tissues (p < 0.05. No significant change was observed in any of the parameters associated with protein, carbohydrate and lipid metabolism, except that exercise caused a decrease in plasma triglyceride, which was further decreased by Q10. In conclusion, these results suggest that Q10 modulates the expression of NFκB, IκB, Nrf2 and HO-1 in exercise training, indicating an anti-inflammatory effect of Q10 and emphasizes its role in antioxidant defense.

  18. Extended q -Gaussian and q -exponential distributions from gamma random variables

    Science.gov (United States)

    Budini, Adrián A.

    2015-05-01

    The family of q -Gaussian and q -exponential probability densities fit the statistical behavior of diverse complex self-similar nonequilibrium systems. These distributions, independently of the underlying dynamics, can rigorously be obtained by maximizing Tsallis "nonextensive" entropy under appropriate constraints, as well as from superstatistical models. In this paper we provide an alternative and complementary scheme for deriving these objects. We show that q -Gaussian and q -exponential random variables can always be expressed as a function of two statistically independent gamma random variables with the same scale parameter. Their shape index determines the complexity q parameter. This result also allows us to define an extended family of asymmetric q -Gaussian and modified q -exponential densities, which reduce to the standard ones when the shape parameters are the same. Furthermore, we demonstrate that a simple change of variables always allows relating any of these distributions with a beta stochastic variable. The extended distributions are applied in the statistical description of different complex dynamics such as log-return signals in financial markets and motion of point defects in a fluid flow.

  19. Invariant-mass distributions for the pp{yields}pp{eta} reaction at Q=10 MeV

    Energy Technology Data Exchange (ETDEWEB)

    Moskal, P.; Czerwinski, E.; Klaja, J.; Klaja, P.; Krzemien, W. [Jagellonian University, Institute of Physics, Cracow (Poland); Research Center Juelich, Nuclear Physics Institute, Juelich (Germany); Czyzykiewicz, R. [Jagellonian University, Institute of Physics, Cracow (Poland); University of Silesia, Institute of Physics, Katowice (Poland); Gil, D.; Jarczyk, L.; Kamys, B.; Silarski, M.; Smyrski, J.; Zdebik, J.; Zielinski, M.J. [Jagellonian University, Institute of Physics, Cracow (Poland); Grzonka, D.; Oelert, W.; Ritman, J.; Sefzick, T.; Wuestner, P. [Research Center Juelich, Nuclear Physics Institute, Juelich (Germany); Khoukaz, A.; Taeschner, A.; Zipper, W. [Westfaelische Wilhelms-Universitaet, IKP, Muenster (Germany); Siemaszko, M. [University of Silesia, Institute of Physics, Katowice (Poland); Wolke, M. [SE-751 05 Uppsala University, Department of Physics and Astronomy, Uppsala (Sweden)

    2010-02-15

    Proton-proton and proton-{eta} invariant-mass distributions and the total cross-section for the pp{yields}pp{eta} reaction have been determined near the threshold at an excess energy of Q=10 MeV. The experiment has been conducted using the COSY-11 detector setup and the cooler synchrotron COSY. The determined invariant-mass spectra reveal significant enhancements in the region of low proton-proton relative momenta, similarly as observed previously at higher excess energies of Q=15.5 MeV and Q=40 MeV. (orig.)

  20. Q fever: a new ocular manifestation

    Directory of Open Access Journals (Sweden)

    Udaondo P

    2011-09-01

    Full Text Available P Udaondo1,3, S Garcia-Delpech1,2, D Salom1,2, M Garcia-Pous1, M Diaz-Llopis1,21Department of Ophthalmology, Nuevo Hospital Universitario y Politecnico La Fe, Valencia, Spain; 2Faculty of Medicine, Universitat de València, Valencia, Spain; 3Universidad Cardenal Herrera CEU, Valencia, SpainAbstract: Q Fever is a zoonosis caused by Coxiella burnetii. Ocular manifestations are rare in this infection. We describe the case of a man complaining of an intense retro-orbital headache, fever, arthralgia, and bilateral loss of vision, who showed an anterior uveitis accompanied by exudative bilateral inferior retinal detachment and optic disk edema. At the beginning, a Vogt–Koyanagi–Harada (VKH syndrome was suspected, but the patient was diagnosed with Q fever and treatment with doxycycline was initiated, with complete resolution after 2 weeks. We wondered if Q fever could unleash VKH syndrome or simulate a VKH syndrome by a similar immunological process.Keywords: Q fever, Vogt–Koyanagi–Harada syndrome, panuveitis, exudative retinal detachment

  1. Q-Switching in a Neodymium Laser

    Science.gov (United States)

    Holgado, Warein; Sola, Inigo J.; Jarque, Enrique Conejero; Jarabo, Sebastian; Roso, Luis

    2012-01-01

    We present a laboratory experiment for advanced undergraduate or graduate laser-related classes to study the performance of a neodymium laser. In the experiment, the student has to build the neodymium laser using an open cavity. After that, the cavity losses are modulated with an optical chopper located inside, so the Q-switching regime is…

  2. Turbulence in a cusp Q device

    DEFF Research Database (Denmark)

    D'Angelo, N.; Pécseli, Hans; Petersen, P. I.

    1974-01-01

    Spectral measurements are reported of plasma turbulence in the Cs plasma of a Q device, modified to a magnetic cusp geometry. The excitation mechanism for the fluctuations appears to be the centrifugal instability discussed by Chen. A transition from an f−5 to an f−3 power spectrum is observed...

  3. Q-Method Extended Kalman Filter

    Science.gov (United States)

    Zanetti, Renato; Ainscough, Thomas; Christian, John; Spanos, Pol D.

    2012-01-01

    A new algorithm is proposed that smoothly integrates non-linear estimation of the attitude quaternion using Davenport s q-method and estimation of non-attitude states through an extended Kalman filter. The new method is compared to a similar existing algorithm showing its similarities and differences. The validity of the proposed approach is confirmed through numerical simulations.

  4. Feedstock Interface Fy2017 Q3 Report

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, Danny [National Renewable Energy Lab. (NREL), Golden, CO (United States); Howe, Daniel [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Westover, Tyler [Idaho National Lab. (INL), Idaho Falls, ID (United States); Klinger, HJordan [Idaho National Lab. (INL), Idaho Falls, ID (United States); Hernandez, Sergio [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-07-10

    This report summarized the results obtained in FY2017 Q3 of a collaborative effort between researchers at NREL, PNNL, and INL to develop rapid screening methods and models to predict the fact pyrolysis conversion performance of a range of biomass materials.

  5. The Danish 22q11 research initiative

    DEFF Research Database (Denmark)

    Schmock, Henriette; Vangkilde, Anders; Larsen, Kit Melissa

    2015-01-01

    mechanisms may come from studies of subjects with homogenous etiologies. Breakthroughs in psychiatric genetics have shown that several genetic anomalies predispose for neurodevelopmental brain disorders. We have established a Danish research initiative to study the common microdeletion at chromosome 22q11...

  6. Partial trisomy 14q and monosomy 20q due to an unbalanced familial translocation

    Energy Technology Data Exchange (ETDEWEB)

    Menasse-Palmer, L; Leo, J.; Cannizaro, L. [Albert Einstein College of Medicine, Bronx, NY (United States)] [and others

    1994-09-01

    Partial trisomy of distal 14q and monosomy of 20q are rare. There have been several reports of a partial distal trisomy 14q with characteristic clinical findings, including hypogonadism and a conotruncal cardiac anomaly. There is no deletion distal 20q syndrome. We have recently examined a newborn with this unique duplication/deletion syndrome. Case report: J.S. was the 2980 gm product of a term uneventful pregnancy delivered to a 24-year-old gravida 2, para 1001 mother. The newborn exam revealed a dysmorphic newborn male with a sloping forehead, bitemporal narrowing, glabellar furrowing and micrognathia. A systolic murmur was audible. The genital abnormalities were micropenis, hypospadias with chordee and bifid scrotum with prominent raphe, and gonads were palpable. A CAT scan of the head revealed grade I IVH. An echocardiogram showed a VSD, ASD and an AP window. A sonogram of the liver showed absence of the gallbladder. Chromosome analysis revealed an abnormal male karyotype containing a derivative 20, subsequently shown to be inherited as a result of malsegregation of a paternal translocation: 46,XY,-20,+der(20)t(14;20)(q32.1;q13.3)pat. The infant fed poorly and required tube feedings and was treated for congestive heart failure with Digoxin, Lasix and oxygen. A decreased cortisol level and cholestasis were noted. The infant died after a cardiopulmonary arrest at one month of age. No post-mortem was obtained. Clinical cytogenetic correlation (conotruncal abnormality and hypogonadism) with partial duplication of distal 14q was positive. This case helps to further delineate duplication 14q and a syndrome due to partial deletion 20q.

  7. Coenzyme Q10 production in plants: current status and future prospects.

    Science.gov (United States)

    Parmar, Sanjay Singh; Jaiwal, Anjali; Dhankher, Om Parkash; Jaiwal, Pawan K

    2015-06-01

    Coenzyme Q10 (CoQ10) or Ubiquinone10 (UQ10), an isoprenylated benzoquinone, is well-known for its role as an electron carrier in aerobic respiration. It is a sole representative of lipid soluble antioxidant that is synthesized in our body. In recent years, it has been found to be associated with a range of patho-physiological conditions and its oral administration has also reported to be of therapeutic value in a wide spectrum of chronic diseases. Additionally, as an antioxidant, it has been widely used as an ingredient in dietary supplements, neutraceuticals, and functional foods as well as in anti-aging creams. Since its limited dietary uptake and decrease in its endogenous synthesis in the body with age and under various diseases states warrants its adequate supply from an external source. To meet its growing demand for pharmaceutical, cosmetic and food industries, there is a great interest in the commercial production of CoQ10. Various synthetic and fermentation of microbial natural producers and their mutated strains have been developed for its commercial production. Although, microbial production is the major industrial source of CoQ10 but due to low yield and high production cost, other cost-effective and alternative sources need to be explored. Plants, being photosynthetic, producing high biomass and the engineering of pathways for producing CoQ10 directly in food crops will eliminate the additional step for purification and thus could be used as an ideal and cost-effective alternative to chemical synthesis and microbial production of CoQ10. A better understanding of CoQ10 biosynthetic enzymes and their regulation in model systems like E. coli and yeast has led to the use of metabolic engineering to enhance CoQ10 production not only in microbes but also in plants. The plant-based CoQ10 production has emerged as a cost-effective and environment-friendly approach capable of supplying CoQ10 in ample amounts. The current strategies, progress and constraints of

  8. Chromosome 15q overgrowth syndrome: Prenatal diagnosis, molecular cytogenetic characterization, and perinatal findings in a fetus with dup(15(q26.2q26.3

    Directory of Open Access Journals (Sweden)

    Chih-Ping Chen

    2011-09-01

    Conclusion: The present case provides evidence for prenatal overgrowth, craniosynostosis, and characteristic facial dysmorphism in association with a duplication of 15q26.2→q26.3 and a duplication of the IGF1R gene. Prenatal diagnosis of fetal overgrowth should include a differential diagnosis of the chromosome 15q overgrowth syndrome.

  9. NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively

    Energy Technology Data Exchange (ETDEWEB)

    Tamimi, R.M.; Montgomery-Dyer, K.; Tapscott, S.J. [Fred Hutchinson Cancer Research Center, Seattle, WA (United States)] [and others

    1997-03-01

    NEUROD2 and NEUROD3 are transcription factors involved in neurogenesis that are related to the basic helix-loop-helix protein NEUROD. NEUROD2 maps to human chromosome 17q12 and mouse chromosome 11. NEUROD3 maps to human chromosome 5q23-q31 and mouse chromosome 13. 16 refs., 2 figs.

  10. [Coenzyme Q10 (Q-ter) in treatment of functional voice disorders].

    Science.gov (United States)

    Sensini, M; Corvino, A; Passeri, L; Gallone, G O; Landolfo, V; Raimondo, L; Giordano, C

    2011-01-01

    Aim of this study was to evaluate the effectivness of Coenzyme Q-Ter and Vitamin A in functional voice disorders. Twenty two patients were treated with CoQ10-ter and vitamin A twice a day for ten days. A general otolaryngological/foniatric and logopedic examination were performed. Videolaringostroboscopy, GIRBAS, Voice Handicap Index questionnaire and Multi-Dimensional Voice analysis were carried out before and after treatment. In all patients an improvement was observed in almost all parameters considered after treatment. CoQ10-ter and Vitamin A risulted effective in treatment of patients with functional voice disorders (caused by vocal "malmenage" or "surmenage").

  11. Tetrasomy 15q11-q13 Diagnosed by FISH in a Patient with Autistic Disorder

    Directory of Open Access Journals (Sweden)

    Karim Ouldim

    2007-01-01

    Full Text Available We report the case of a Moroccan boy with mental retardation, hyperactivity, epilepsy, developmental problems and behavioural disorders. Cytogenetic analysis showed the presence of a supernumerary marker chromosome. Molecular cytogenetics allowed us to determine the marker as an inverted duplication of chromosome 15. It is the first case of a Moroccan patient with tetrasomy 15q in which fluorescence in situ hybridization (FISH enabled us to specify the diagnosis. Interestingly, this patient has an infantile autism with cytogenetic abnormalities on chromosomal region 15q11-q13 as reported in patients with Autistic Disorder.

  12. CERTAIN INEQUALITIES INVOLVING THE Q-DEFORMED GAMMA FUNCTION

    Directory of Open Access Journals (Sweden)

    K. Nantomah

    2014-11-01

    Full Text Available This paper in inspired by the work of J.Sándor in 2006. In paper, the authors establish some double inequalities involving the ratio (Γq(x+1/(Γq(x+1/2, where Γq(x is the q-deformation of the classical Gamma function denoted by Γ(x. The method employed in presenting the results makes use of Jackson׳s q-integral representation of the q-deformed Gamma function. In addition, Hőlder׳s inequality for the q-integral, as well as some basic analytical techniques involving the q-analogue of the psi function are used. As a consequence, q-analogues of the classical Wendel׳s asymptotic relation are obtained. At the end, sharpness of the inequalities established in this paper is investigated.

  13. How does gravity save or kill Q-balls?

    International Nuclear Information System (INIS)

    Tamaki, Takashi; Sakai, Nobuyuki

    2011-01-01

    We explore stability of gravitating Q-balls with potential V 4 (φ)=(m 2 /2)φ 2 -λφ 4 +(φ 6 /M 2 ) via catastrophe theory, as an extension of our previous work on Q-balls with potential V 3 (φ)=(m 2 /2)φ 2 -μφ 3 +λφ 4 . In flat spacetime Q-balls with V 4 in the thick-wall limit are unstable and there is a minimum charge Q min , where Q-balls with Q min are nonexistent. If we take self-gravity into account, on the other hand, there exist stable Q-balls with arbitrarily small charge, no matter how weak gravity is. That is, gravity saves Q-balls with small charge. We also show how stability of Q-balls changes as gravity becomes strong.

  14. Q-space analysis of light scattering by ice crystals

    Science.gov (United States)

    Heinson, Yuli W.; Maughan, Justin B.; Ding, Jiachen; Chakrabarti, Amitabha; Yang, Ping; Sorensen, Christopher M.

    2016-12-01

    Q-space analysis is applied to extensive simulations of the single-scattering properties of ice crystals with various habits/shapes over a range of sizes. The analysis uncovers features common to all the shapes: a forward scattering regime with intensity quantitatively related to the Rayleigh scattering by the particle and the internal coupling parameter, followed by a Guinier regime dependent upon the particle size, a complex power law regime with incipient two dimensional diffraction effects, and, in some cases, an enhanced backscattering regime. The effects of significant absorption on the scattering profile are also studied. The overall features found for the ice crystals are similar to features in scattering from same sized spheres.

  15. Formation of q bar q resonances in the bar NN system

    International Nuclear Information System (INIS)

    Ivanov, N.Ya.

    1995-01-01

    The formation of q bar q resonances lying on the leading Regge trajectories in the bar NN system is studied in the quark-gluon string model. The model predicts strong suppression of the decays of q bar q states into bar NN pairs in relation to two-meson modes. The author's analysis shows that the contributions of the resonances f 4 (2050) (I G J PC = 0 + 4 ++ ), ρ 5 (2240) (I G J PC = 1 + 5 -- ), and f 6 (2510) (I G J PC = 0 + 6 ++ ) to the processes of two-meson bar NN annihilation (bar pp → ππ, bar KK, hor-ellipsis) are about 1% of the corresponding experimental integrated cross sections. 30 refs., 2 figs., 1 tab

  16. Comparative genomic hybridization analysis detects frequent over-representation of DNA sequences at 3q, 7p, 8q and 18q in head and neck carcinomas

    DEFF Research Database (Denmark)

    Bergamo, N A; Rogatto, S R; Poli-Frederico, R C

    2000-01-01

    Comparative genomic hybridization (CGH) was used to identify chromosomal imbalances in 19 samples of squamous cell carcinoma of the head and neck (HNSCC). The chromosome arms most often over-represented were 3q (48%), 8q (42%), and 7p (32%); in many cases, these changes were observed at high copy...... and 2q material were detected in patients exhibiting a clinical history of recurrence and/or metastasis followed by terminal disease. This association suggests that gain of 1q and 2q may be a new marker of head and neck tumors with a refractory clinical response....

  17. Deletion 22q13.3 syndrome

    Directory of Open Access Journals (Sweden)

    Phelan Mary C

    2008-05-01

    Full Text Available Abstract The deletion 22q13.3 syndrome (deletion 22q13 syndrome or Phelan-McDermid syndrome is a chromosome microdeletion syndrome characterized by neonatal hypotonia, global developmental delay, normal to accelerated growth, absent to severely delayed speech, and minor dysmorphic features. The deletion occurs with equal frequency in males and females and has been reported in mosaic and non-mosaic forms. Due to lack of clinical recognition and often insufficient laboratory testing, the syndrome is under-diagnosed and its true incidence remains unknown. Common physical traits include long eye lashes, large or unusual ears, relatively large hands, dysplastic toenails, full brow, dolicocephaly, full cheeks, bulbous nose, and pointed chin. Behavior is autistic-like with decreased perception of pain and habitual chewing or mouthing. The loss of 22q13.3 can result from simple deletion, translocation, ring chromosome formation and less common structural changes affecting the long arm of chromosome 22, specifically the region containing the SHANK3 gene. The diagnosis of deletion 22q13 syndrome should be considered in all cases of hypotonia of unknown etiology and in individuals with absent speech. Although the deletion can sometimes be detected by high resolution chromosome analysis, fluorescence in situ hybridization (FISH or array comparative genomic hybridization (CGH is recommended for confirmation. Differential diagnosis includes syndromes associated with hypotonia, developmental delay, speech delay and/or autistic-like affect (Prader-Willi, Angelman, Williams, Smith-Magenis, Fragile X, Sotos, FG, trichorhinophalangeal and velocardiofacial syndromes, autism spectrum disorders, cerebral palsy. Genetic counseling is recommended and parental laboratory studies should be considered to identify cryptic rearrangements and detect parental mosaicism. Prenatal diagnosis should be offered for future pregnancies in those families with inherited rearrangements

  18. q-bosons, Toda lattice, Pieri rules and Baxter q-operator

    International Nuclear Information System (INIS)

    Duval, Antoine; Pasquier, Vincent

    2016-01-01

    We use the Pieri rules to recover the q-boson model and show it is equivalent to a discretized version of the relativistic Toda chain. We identify its semi infinite transfer matrix and the corresponding Baxter Q-matrix with half vertex operators related by an ω-duality transformation. We observe that the scalar product of two higher spin XXZ wave functions can be expressed with a Gaudin determinant. (paper)

  19. q-bar q condensate for light quarks beyond the chiral limit

    International Nuclear Information System (INIS)

    Williams, R.; Fischer, C.S.; Pennington, M.R.

    2007-01-01

    We determine the q-bar q condensate for quark masses from zero up to that of the strange quark within a phenomenologically successful modelling of continuum QCD by solving the quark Schwinger-Dyson equation. The existence of multiple solutions to this equation is the key to an accurate and reliable extraction of this condensate using the operator product expansion. We explain why alternative definitions fail to give the physical condensate

  20. HELICOBACTER PYLORI AND t(11;18(q21;q21 TRANSLOCATION IN GASTRIC MALT LYMPHOMA

    Directory of Open Access Journals (Sweden)

    Karine Sampaio LIMA

    2014-04-01

    Full Text Available Context Gastric mucosa-associated lymphoid tissue (MALT lymphoma is clearly associated with Helicobacter pylori gastritis and can be cured with anti- H pylori therapy alone. The presence of t(11;18(q21;q21 translocation is thought to predict a lower response rate to anti- H pylori treatment. Objectives To study the presence of t(11;18(q21;q21 genetic translocation and its clinical impact in low-grade gastric MALT lymphoma Brazilian patients. Methods A consecutive series of eight patients with gastric MALT lymphoma were submitted to gastroscopy, endoscopic ultrasound, histopathological examination, H pylori search and RT-PCR-based methodology. All patients received anti-H pylori treatment. Eradicated patients were followed-up every 3-6 months for 2 years. Results Eight patients were studied. All patients had tumor involvement restricted to the mucosa or submucosa and seven patients had low-grade gastric MALT lymphoma. All infected patients achieved H pylori eradication. Histological tumor regression was observed in 5/7 (71% of the low-grade gastric MALT lymphoma patients. The presence of t(11;18(q21;q21 translocation was found in 4 (57% of these patients; among them only two had histological tumor regression following H pylori eradication. Conclusions RT-PCR is a feasible and efficient method to detect t(11;18(q21;q21 translocation, being carried out in routine molecular biology laboratories. The early detection of such translocation can be very helpful for better targeting the therapy to be applied to gastric MALT lymphoma patients.

  1. A high-order q-difference equation for q-Hahn multiple orthogonal polynomials

    DEFF Research Database (Denmark)

    Arvesú, J.; Esposito, Chiara

    2012-01-01

    A high-order linear q-difference equation with polynomial coefficients having q-Hahn multiple orthogonal polynomials as eigenfunctions is given. The order of the equation coincides with the number of orthogonality conditions that these polynomials satisfy. Some limiting situations when are studie....... Indeed, the difference equation for Hahn multiple orthogonal polynomials given in Lee [J. Approx. Theory (2007), ), doi: 10.1016/j.jat.2007.06.002] is obtained as a limiting case....

  2. On sums of q-independent SU[sub q](2) quantum variables

    Energy Technology Data Exchange (ETDEWEB)

    Lenczewski, R. (Politechnika Wroclawska, Wroclaw (Poland). Hugo Steinhaus Center for Stochastic Methods)

    1993-05-01

    A representation-free approach to the q-analog of the quantum central limit theorem for C=SU[sub 1](2) is presented. It is shown that for certain functions [phi][epsilon]-C* one can derive a version of a quantum central limit theorem (qclt) with [radical][N] as a scaling parameter, which may be viewed as a q-analog of qclt. (orig.).

  3. qqman: an R package for visualizing GWAS results using Q-Q and manhattan plots

    OpenAIRE

    Turner, Stephen

    2014-01-01

    Summary: Genome-wide association studies (GWAS) have identified thousands of human trait-associated single nucleotide polymorphisms. Here, I describe a freely available R package for visualizing GWAS results using Q-Q and manhattan plots. The qqman package enables the flexible creation of manhattan plots, both genome-wide and for single chromosomes, with optional highlighting of SNPs of interest. Availability: qqman is released under the GNU General Public License, and is freely available on ...

  4. Wagner vitreoretinal degeneration with genetic linkage refinement on chromosome 5q13-q14.

    Science.gov (United States)

    Zech, J C; Morlé, L; Vincent, P; Alloisio, N; Bozon, M; Gonnet, C; Milazzo, S; Grange, J D; Trepsat, C; Godet, J; Plauchu, H

    1999-05-01

    It has been previously described that Wagner disease is linked to chromosome 5q13-q14. This study was carried out to describe the ophthalmological aspects and report the results of genetic linkage analysis in a large pedigree affected by Wagner disease. Fourty members of one same family agreed to be examined. Twenty patients presented vitreoretinal degeneration in both eyes without any extra-ocular abnormalities. In young patients, visual acuity was usually normal after correction of frequent mild myopia. Presenile cataracts progressed by the third decade and required removal for visual rehabilitation. The primary disorder involved an abnormal vitreous. A few avascular vitreous bands were usually the only optical feature in the mostly empty vitreous cavity. A circumferential vitreous condensation formed in contact with the retina on many spots. Less common retinal findings included retinal detachment, abnormal retinal pigmentation, progressive atrophy of the RPE simulating choroideremia and lattice degeneration. Genetic analysis revealed a highly significant linkage (lod score >5.0) between the disease and 10 markers of the chromosome 5q13-q14 region. Two recombination events allowed us to refine the linked interval to 20 cM between the D5S650 and D5S618 markers. Ophthalmological aspects of Wagner's disease appear to progress with age. Regular ophthalmological examination is important for detecting retinal abnormalities. The gene involved in Wagner's disease lies in a 20 cM interval on chromosome 5q13-q14.

  5. On q-power cycles in cubic graphs

    DEFF Research Database (Denmark)

    Bensmail, Julien

    2017-01-01

    In the context of a conjecture of Erdos and Gyárfás, we consider, for any q ≥ 2, the existence of q-power cycles (i.e. with length a power of q) in cubic graphs. We exhibit constructions showing that, for every q ≥ 3, there exist arbitrarily large cubic graphs with no q-power cycles. Concerning...... the remaining case q = 2 (which corresponds to the conjecture of Erdos and Gyárfás), we show that there exist arbitrarily large cubic graphs whose only 2-power cycles have length 4 only, or 8 only....

  6. How does gravity save or kill Q-balls?

    OpenAIRE

    Tamaki, Takashi; Sakai, Nobuyuki

    2011-01-01

    We explore stability of gravitating Q-balls with potential $V_4(\\phi)={m^2\\over2}\\phi^2-\\lambda\\phi^4+\\frac{\\phi^6}{M^2}$ via catastrophe theory, as an extension of our previous work on Q-balls with potential $V_3(\\phi)={m^2\\over2}\\phi^2-\\mu\\phi^3+\\lambda\\phi^4$. In flat spacetime Q-balls with $V_4$ in the thick-wall limit are unstable and there is a minimum charge $Q_{{\\rm min}}$, where Q-balls with $Q

  7. 22q11.2 deletion syndrome

    Science.gov (United States)

    McDonald-McGinn, Donna M.; Sullivan, Kathleen E.; Marino, Bruno; Philip, Nicole; Swillen, Ann; Vorstman, Jacob A. S.; Zackai, Elaine H.; Emanuel, Beverly S.; Vermeesch, Joris R.; Morrow, Bernice E.; Scambler, Peter J.; Bassett, Anne S.

    2016-01-01

    22q11.2 deletion syndrome (22q11.2DS) is the most common chromosomal microdeletion disorder, estimated to result mainly from de novo non-homologous meiotic recombination events occurring in approximately 1 in every 1,000 fetuses. The first description in the English language of the constellation of findings now known to be due to this chromosomal difference was made in the 1960s in children with DiGeorge syndrome, who presented with the clinical triad of immunodeficiency, hypoparathyroidism and congenital heart disease. The syndrome is now known to have a heterogeneous presentation that includes multiple additional congenital anomalies and later-onset conditions, such as palatal, gastrointestinal and renal abnormalities, autoimmune disease, variable cognitive delays, behavioural phenotypes and psychiatric illness — all far extending the original description of DiGeorge syndrome. Management requires a multidisciplinary approach involving paediatrics, general medicine, surgery, psychiatry, psychology, interventional therapies (physical, occupational, speech, language and behavioural) and genetic counselling. Although common, lack of recognition of the condition and/or lack of familiarity with genetic testing methods, together with the wide variability of clinical presentation, delays diagnosis. Early diagnosis, preferably prenatally or neonatally, could improve outcomes, thus stressing the importance of universal screening. Equally important, 22q11.2DS has become a model for understanding rare and frequent congenital anomalies, medical conditions, psychiatric and developmental disorders, and may provide a platform to better understand these disorders while affording opportunities for translational strategies across the lifespan for both patients with 22q11.2DS and those with these associated features in the general population. PMID:27189754

  8. The Main Properties of q-Functions

    OpenAIRE

    Nina O. Virchenko; Olena V. Ovcharenko

    2017-01-01

    Background.  The new generalization of the function of complex variable (q-function) is considered, its main properties are investigated. Such distributions have a special place among the special functions due to their widespread use in many areas of applied mathematics. Objective. The aim of the paper is to study the new generalization of the function of complex variable for application in applied sciences. Methods. To obtain scientific results the general methods of the mathematical a...

  9. 9q22 Deletion - First Familial Case

    Directory of Open Access Journals (Sweden)

    Yamamoto Toshiyuki

    2011-06-01

    Full Text Available Abstract Background Only 29 cases of constitutional 9q22 deletions have been published and all have been sporadic. Most associate with Gorlin syndrome or nevoid basal cell carcinoma syndrome (NBCCS, MIM #109400 due to haploinsufficiency of the PTCH1 gene (MIM *601309. Methods and Results We report two mentally retarded female siblings and their cognitively normal father, all carrying a similar 5.3 Mb microdeletion at 9q22.2q22.32, detected by array CGH (244 K. The deletion does not involve the PTCH1 gene, but instead 30 other gene,s including the ROR2 gene (MIM *602337 which causing both brachydactyly type 1 (MIM #113000 and Robinow syndrome (MIM #268310, and the immunologically active SYK gene (MIM *600085. The deletion in the father was de novo and FISH analysis of blood lymphocytes did not suggest mosaicism. All three patients share similar mild dysmorphic features with downslanting palpebral fissures, narrow, high bridged nose with small nares, long, deeply grooved philtrum, ears with broad helix and uplifted lobuli, and small toenails. All have significant dysarthria and suffer from continuous middle ear and upper respiratory infections. The father also has a funnel chest and unilateral hypoplastic kidney but the daughters have no malformations. Conclusions This is the first report of a familial constitutional 9q22 deletion and the first deletion studied by array-CGH which does not involve the PTCH1 gene. The phenotype and penetrance are variable and the deletion found in the cognitively normal normal father poses a challenge in genetic counseling.

  10. Contrasting roles of the ABCG2 Q141K variant in prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Sobek, Kathryn M. [Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States); Cummings, Jessica L. [Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States); Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA (United States); Bacich, Dean J. [Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States); Department of Urology, University of Texas Health Science Center, San Antonio, TX (United States); O’Keefe, Denise S., E-mail: OKeefeD@uthscsa.edu [Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA (United States); Department of Urology, University of Texas Health Science Center, San Antonio, TX (United States)

    2017-05-01

    ABCG2 is a membrane transport protein that effluxes growth-promoting molecules, such as folates and dihydrotestosterone, as well as chemotherapeutic agents. Therefore it is important to determine how variants of ABCG2 affect the transporter function in order to determine whether modified treatment regimens may be necessary for patients harboring ABCG2 variants. Previous studies have demonstrated an association between the ABCG2 Q141K variant and overall survival after a prostate cancer diagnosis. We report here that in patients with recurrent prostate cancer, those who carry the ABCG2 Q141K variant had a significantly shorter time to PSA recurrence post-prostatectomy than patients homozygous for wild-type ABCG2 (P=0.01). Transport studies showed that wild-type ABCG2 was able to efflux more folic acid than the Q141K variant (P<0.002), suggesting that retained tumoral folate contributes to the decreased time to PSA recurrence in the Q141K variant patients. In a seemingly conflicting study, it was previously reported that docetaxel-treated Q141K variant prostate cancer patients have a longer survival time. We found this may be due to less efficient docetaxel efflux in cells with the Q141K variant versus wild-type ABCG2. In human prostate cancer tissues, confocal microscopy revealed that all genotypes had a mixture of cytoplasmic and plasma membrane staining, with noticeably less staining in the two homozygous KK patients. In conclusion, the Q141K variant plays contrasting roles in prostate cancer: 1) by decreasing folate efflux, increased intracellular folate levels result in enhanced tumor cell proliferation and therefore time to recurrence decreases; and 2) in patients treated with docetaxel, by decreasing its efflux, intratumoral docetaxel levels and tumor cell drug sensitivity increase and therefore patient survival time increases. Taken together, these data suggest that a patient's ABCG2 genotype may be important when determining a personalized treatment

  11. Degradation of AF1Q by chaperone-mediated autophagy

    International Nuclear Information System (INIS)

    Li, Peng; Ji, Min; Lu, Fei; Zhang, Jingru; Li, Huanjie; Cui, Taixing; Li Wang, Xing; Tang, Dongqi; Ji, Chunyan

    2014-01-01

    AF1Q, a mixed lineage leukemia gene fusion partner, is identified as a poor prognostic biomarker for pediatric acute myeloid leukemia (AML), adult AML with normal cytogenetic and adult myelodysplastic syndrome. AF1Q is highly regulated during hematopoietic progenitor differentiation and development but its regulatory mechanism has not been defined clearly. In the present study, we used pharmacological and genetic approaches to influence chaperone-mediated autophagy (CMA) and explored the degradation mechanism of AF1Q. Pharmacological inhibitors of lysosomal degradation, such as chloroquine, increased AF1Q levels, whereas activators of CMA, including 6-aminonicotinamide and nutrient starvation, decreased AF1Q levels. AF1Q interacts with HSPA8 and LAMP-2A, which are core components of the CMA machinery. Knockdown of HSPA8 or LAMP-2A increased AF1Q protein levels, whereas overexpression showed the opposite effect. Using an amino acid deletion AF1Q mutation plasmid, we identified that AF1Q had a KFERQ-like motif which was recognized by HSPA8 for CMA-dependent proteolysis. In conclusion, we demonstrate for the first time that AF1Q can be degraded in lysosomes by CMA. - Highlights: • Chaperone-mediated autophagy (CMA) is involved in the degradation of AF1Q. • Macroautophagy does not contribute to the AF1Q degradation. • AF1Q has a KFERQ-like motif that is recognized by CMA core components

  12. Coenzyme Q10 Supplementation in Aging and Disease

    Directory of Open Access Journals (Sweden)

    Juan D. Hernández-Camacho

    2018-02-01

    Full Text Available Coenzyme Q (CoQ is an essential component of the mitochondrial electron transport chain and an antioxidant in plasma membranes and lipoproteins. It is endogenously produced in all cells by a highly regulated pathway that involves a mitochondrial multiprotein complex. Defects in either the structural and/or regulatory components of CoQ complex or in non-CoQ biosynthetic mitochondrial proteins can result in a decrease in CoQ concentration and/or an increase in oxidative stress. Besides CoQ10 deficiency syndrome and aging, there are chronic diseases in which lower levels of CoQ10 are detected in tissues and organs providing the hypothesis that CoQ10 supplementation could alleviate aging symptoms and/or retard the onset of these diseases. Here, we review the current knowledge of CoQ10 biosynthesis and primary CoQ10 deficiency syndrome, and have collected published results from clinical trials based on CoQ10 supplementation. There is evidence that supplementation positively affects mitochondrial deficiency syndrome and the symptoms of aging based mainly on improvements in bioenergetics. Cardiovascular disease and inflammation are alleviated by the antioxidant effect of CoQ10. There is a need for further studies and clinical trials involving a greater number of participants undergoing longer treatments in order to assess the benefits of CoQ10 treatment in metabolic syndrome and diabetes, neurodegenerative disorders, kidney diseases, and human fertility.

  13. Degradation of AF1Q by chaperone-mediated autophagy

    Energy Technology Data Exchange (ETDEWEB)

    Li, Peng; Ji, Min; Lu, Fei; Zhang, Jingru [Department of Hematology, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan 250012 (China); Li, Huanjie; Cui, Taixing; Li Wang, Xing [Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan 250012 (China); Tang, Dongqi, E-mail: tangdq@sdu.edu.cn [Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan 250012 (China); Center for Stem Cell and Regenerative Medicine, The Second Hospital of Shandong University, Jinan 250033 (China); Ji, Chunyan, E-mail: jichunyan@sdu.edu.cn [Department of Hematology, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan 250012 (China)

    2014-09-10

    AF1Q, a mixed lineage leukemia gene fusion partner, is identified as a poor prognostic biomarker for pediatric acute myeloid leukemia (AML), adult AML with normal cytogenetic and adult myelodysplastic syndrome. AF1Q is highly regulated during hematopoietic progenitor differentiation and development but its regulatory mechanism has not been defined clearly. In the present study, we used pharmacological and genetic approaches to influence chaperone-mediated autophagy (CMA) and explored the degradation mechanism of AF1Q. Pharmacological inhibitors of lysosomal degradation, such as chloroquine, increased AF1Q levels, whereas activators of CMA, including 6-aminonicotinamide and nutrient starvation, decreased AF1Q levels. AF1Q interacts with HSPA8 and LAMP-2A, which are core components of the CMA machinery. Knockdown of HSPA8 or LAMP-2A increased AF1Q protein levels, whereas overexpression showed the opposite effect. Using an amino acid deletion AF1Q mutation plasmid, we identified that AF1Q had a KFERQ-like motif which was recognized by HSPA8 for CMA-dependent proteolysis. In conclusion, we demonstrate for the first time that AF1Q can be degraded in lysosomes by CMA. - Highlights: • Chaperone-mediated autophagy (CMA) is involved in the degradation of AF1Q. • Macroautophagy does not contribute to the AF1Q degradation. • AF1Q has a KFERQ-like motif that is recognized by CMA core components.

  14. 7Q10 flows for SRS streams

    International Nuclear Information System (INIS)

    Chen, K.F.

    1996-01-01

    The Environmental Transport Group of the Environmental Technology Section was requested to predict the seven-day ten-year low flow (7Q10 flow) for the SRS streams based on historical stream flow records. Most of the historical flow records for the SRS streams include reactor coolant water discharged from the reactors and process water released from the process facilities. The most straight forward way to estimate the stream daily natural flow is to subtract the measured upstream reactor and/or facility daily effluents from the measured downstream daily flow. Unfortunately, this method does not always work, as indicated by the fact that sometimes the measured downstream volumetric flow rates are lower than the reactor effluent volumetric flow rates. For those cases that cannot be analyzed with the simple subtracting method, an alternative method was used to estimate the stream natural flows by statistically separating reactor coolant and process water flow data. The correlation between the calculated 7Q10 flows and the watershed areas for Four Mile Branch and Pen Branch agrees with that calculated by the USGS for Upper Three Runs and Lower Three Runs Creeks. The agreement between these two independent calculations lends confidence to the 7Q10 flow calculations presented in this report

  15. MD2190: Q" Stabilization during injection

    CERN Document Server

    Schenk, Michael; Li, Kevin Shing Bruce; Malina, Lukas; Metral, Elias; Tomas Garcia, Rogelio; CERN. Geneva. ATS Department

    2018-01-01

    This MD is a follow-up study of MD1831, where single bunches were stabilized against impedance-driven instabilities at 6.5 TeV in the LHC with Q''. The goals are (i) to explore whether an amplitude detuning free Q'' knob can be implemented at injection energy, and (ii) whether Q'' can provide beam stability at injection, where the beams suffer mostly from electron cloud effects. Ideally, this would relax the use of the Landau octupoles and may help in preserving the beam quality by reducing dynamic aperture limitations originating from the octupoles. The MD has been split into two parts: First, optics corrections were put in place to minimize beta-beating and linear coupling introduced by the knobs. The corrections were achieved by means of orbit bumps and skew quadrupole knobs. Machine safety was then validated with loss maps. While the betatron loss maps were approved, the off-momentum maps showed a priori unexpected losses in several arcs and the MD was stopped at this point for reasons of machine protecti...

  16. I-Love-Q to the extreme

    Science.gov (United States)

    Silva, Hector O.; Yunes, Nicolás

    2018-01-01

    Certain bulk properties of neutron stars, in particular their moment of inertia, rotational quadrupole moment and tidal Love number, when properly normalized, are related to one another in a nearly equation of state independent way. The goal of this paper is to test these relations with extreme equations of state at supranuclear densities constrained to satisfy only a handful of generic, physically sensible conditions. By requiring that the equation of state be (i) barotropic and (ii) its associated speed of sound be real, we construct a piecewise function that matches a tabulated equation of state at low densities, while matching a stiff equation of state parametrized by its sound speed in the high-density region. We show that the I-Love-Q relations hold to 1 percent with this class of equations of state, even in the extreme case where the speed of sound becomes superluminal and independently of the transition density. We also find further support for the interpretation of the I-Love-Q relations as an emergent symmetry due to the nearly constant eccentricity of isodensity contours inside the star. These results reinforce the robustness of the I-Love-Q relations against our current incomplete picture of physics at supranuclear densities, while strengthening our confidence in the applicability of these relations in neutron star astrophysics.

  17. Complement protein C1q induces maturation of human dendritic cells

    DEFF Research Database (Denmark)

    Csomor, Eszter; Bajtay, Zsuzsa; Sándor, Noémi

    2007-01-01

    Maturation of dendritic cells (DCs) is known to be induced by several stimuli, including microbial products, inflammatory cytokines and immobilized IgG, as demonstrated recently. Since immune complexes formed in vivo also contain C1q, moreover apoptotic cells and several pathogens fix C1q...... activity of the cells was assessed by measuring cytokine secretion and their ability to activate allogeneic T lymphocytes. Cytokine production by T cells co-cultured with C1q-matured DCs was also investigated. C1q, but not the structurally related mannose-binding lectin was found to bind to imMDC in a dose......-dependent manner and induced NF-kappaB translocation to the nucleus. Immobilized C1q induced maturation of MDCs and enhanced secretion of IL-12 and TNF-alpha, moreover, elevated their T-cell stimulating capacity. As IFN-gamma levels were increased in supernatants of MDC-T cell co-cultures, our data suggest that C1...

  18. Four novel Loci (19q13, 6q24, 12q24, and 5q14 influence the microcirculation in vivo.

    Directory of Open Access Journals (Sweden)

    M Kamran Ikram

    2010-10-01

    Full Text Available There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify genetic variants associated with retinal vascular caliber. We analyzed data from four population-based discovery cohorts with 15,358 unrelated Caucasian individuals, who are members of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE consortium, and replicated findings in four independent Caucasian cohorts (n  =  6,652. All participants had retinal photography and retinal arteriolar and venular caliber measured from computer software. In the discovery cohorts, 179 single nucleotide polymorphisms (SNP spread across five loci were significantly associated (p<5.0×10(-8 with retinal venular caliber, but none showed association with arteriolar caliber. Collectively, these five loci explain 1.0%-3.2% of the variation in retinal venular caliber. Four out of these five loci were confirmed in independent replication samples. In the combined analyses, the top SNPs at each locus were: rs2287921 (19q13; p  =  1.61×10(-25, within the RASIP1 locus, rs225717 (6q24; p = 1.25×10(-16, adjacent to the VTA1 and NMBR loci, rs10774625 (12q24; p  =  2.15×10(-13, in the region of ATXN2,SH2B3 and PTPN11 loci, and rs17421627 (5q14; p = 7.32×10(-16, adjacent to the MEF2C locus. In two independent samples, locus 12q24 was also associated with coronary heart disease and hypertension. Our population-based genome-wide association study demonstrates four novel loci associated with retinal venular caliber, an endophenotype of the microcirculation associated with clinical cardiovascular disease. These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular

  19. Novel features of 3q29 deletion syndrome: Results from the 3q29 registry

    Science.gov (United States)

    Glassford, Megan R.; Rosenfeld, Jill A.; Freedman, Alexa A.; Zwick, Michael E.

    2016-01-01

    3q29 deletion syndrome is caused by a recurrent, typically de novo heterozygous 1.6 Mb deletion, but because incidence of the deletion is rare (1 in 30,000 births) the phenotype is not well described. To characterize the range of phenotypic manifestations associated with 3q29 deletion syndrome, we have developed an online registry (3q29deletion.org) for ascertainment of study subjects and phenotypic data collection via Internet‐based survey instruments. We report here on data collected during the first 18 months of registry operation, from 44 patients. This is the largest cohort of 3q29 deletion carriers ever assembled and surveyed in a systematic way. Our data reveal that 28% of registry participants report neuropsychiatric phenotypes, including anxiety disorder, panic attacks, depression, bipolar disorder, and schizophrenia. Other novel findings include a high prevalence (64%) of feeding problems in infancy and reduced weight at birth for 3q29 deletion carriers (average reduction 13.9 oz (394 g), adjusted for gestational age and sex, P = 6.5e‐07). We further report on the frequency of heart defects, autism, recurrent ear infections, gastrointestinal phenotypes, and dental phenotypes, among others. We also report on the expected timing of delayed developmental milestones. This is the most comprehensive description of the 3q29 deletion phenotype to date. These results are clinically actionable toward improving patient care for 3q29 deletion carriers, and can guide the expectations of physicians and parents. These data also demonstrate the value of patient‐reported outcomes to reveal the full phenotypic spectrum of rare genomic disorders. © 2016 The Authors. American Journal of Medical Genetics Part A Published by Wiley Periodicals, Inc. PMID:26738761

  20. q-deformed conformal superalgebra and its Hopf subalgebras

    International Nuclear Information System (INIS)

    Dobrev, V.K.; Lukierski, J.; Sobczyk, J.; Tolstoy, V.N.

    1992-07-01

    We present in detail a Hopf superalgebra U q (su(2,2/2)) which is a q-deformation of the conformal superalgebra su(2,2/1). The superalgebra U q (su(2,2/1)) contains as a subalgebra a q-deformed super-Poincare algebra and as Hopf subalgebras two conjugate 16-generator q-deformed super-Weyl algebras, which are q-deformation of parabolic subalgebras of su(2,2/1). We use several (anti-) involutions, including the standard Cartan involution and a *-antiinvolution under which the super-Weyl algebras are *-subalgebras of U q (su(2,2/1)). The q-deformed Lorentz algebra is Hopf subalgebra of both Weyl algebras and is preserved by all (anti-) involutions considered. (author). 26 refs

  1. Multiple blocking sets in PG(n,q), n>=3

    DEFF Research Database (Denmark)

    Barat, Janos

    2004-01-01

    This article discusses minimal s-fold blocking sets B in PG (n, q), q = ph, p prime, q > 661, n > 3, of size |B| > sq + cp q2/3 - (s - 1) (s - 2)/2 (s > min (cp q1/6, q1/4/2)). It is shown that these s-fold blocking sets contain the disjoint union of a collection of s lines and/or Baer subplanes....... To obtain these results, we extend results of Blokhuis–Storme–Szönyi on s-fold blocking sets in PG(2, q) to s-fold blocking sets having points to which a multiplicity is given. Then the results in PG(n, q), n ≥ 3, are obtained using projection arguments. The results of this article also improve results...

  2. Genetics Home Reference: 17q12 deletion syndrome

    Science.gov (United States)

    ... with 17q12 deletion syndrome have delayed development (particularly speech and language delays), intellectual disability, or behavioral or psychiatric disorders. Behavioral and psychiatric conditions that have been reported in people with 17q12 deletion syndrome include autism ...

  3. Entire solutions of Fermat type q-difference differential equations

    Directory of Open Access Journals (Sweden)

    Kai Liu

    2013-02-01

    Full Text Available In this article, we describe the finite-order transcendental entire solutions of Fermat type $q$-difference and $q$-difference differential equations. In addition, we investigate the similarities and other properties among those solutions.

  4. Coenzyme Q10 defects may be associated with a deficiency of Q10-independent mitochondrial respiratory chain complexes

    Directory of Open Access Journals (Sweden)

    Konstantina Fragaki

    Full Text Available BACKGROUND: Coenzyme Q10 (CoQ10 or ubiquinone deficiency can be due either to mutations in genes involved in CoQ10 biosynthesis pathway, or to mutations in genes unrelated to CoQ10 biosynthesis. CoQ10 defect is the only oxidative phosphorylation disorder that can be clinically improved after oral CoQ10 supplementation. Thus, early diagnosis, first evoked by mitochondrial respiratory chain (MRC spectrophotometric analysis, then confirmed by direct measurement of CoQ10 levels, is of critical importance to prevent irreversible damage in organs such as the kidney and the central nervous system. It is widely reported that CoQ10 deficient patients present decreased quinone-dependent activities (segments I + III or G3P + III and II + III while MRC activities of complexes I, II, III, IV and V are normal. We previously suggested that CoQ10 defect may be associated with a deficiency of CoQ10-independent MRC complexes. The aim of this study was to verify this hypothesis in order to improve the diagnosis of this disease. RESULTS: To determine whether CoQ10 defect could be associated with MRC deficiency, we quantified CoQ10 by LC-MSMS in a cohort of 18 patients presenting CoQ10-dependent deficiency associated with MRC defect. We found decreased levels of CoQ10 in eight patients out of 18 (45 %, thus confirming CoQ10 disease. CONCLUSIONS: Our study shows that CoQ10 defect can be associated with MRC deficiency. This could be of major importance in clinical practice for the diagnosis of a disease that can be improved by CoQ10 supplementation.

  5. Pair q-coherent states and their antibunching effects

    International Nuclear Information System (INIS)

    Wang Zhongqing; Li Junhong; An Guanglei; Chongqing Univ. of Posts and Telecommunications, Chongqing

    2005-01-01

    Using the properties of the q-deformed boson creation and annihilation operators and their inverse operators, two kind of q-deformed pair coherent states are introduced. Antibunching effects and correlation properties between two modes in the states are investigated. It is shown that q-deformed pair coherent states exhibit antibunching effects and the photons of the two modes are correlated. These nonclassical effects are influenced by the parameter q. These effects increase when |lnq| increases. (authors)

  6. Genetics Home Reference: 5q31.3 microdeletion syndrome

    Science.gov (United States)

    ... up of a patient with 5q31.3 microdeletion syndrome and the smallest de novo 5q31.2q31.3 deletion involving PURA. Mol Cytogenet. 2015 Nov 14;8:89. doi: 10.1186/s13039-015-0193-9. eCollection 2015. ... 5q31.3 Microdeletion syndrome: clinical and molecular characterization of two further cases. ...

  7. On massless representations of the Q-deformed Poincare algebra

    International Nuclear Information System (INIS)

    Ogievetsky, O.; Pillin, M.; Schmidke, W.B.; Wess, J.

    1993-01-01

    This talk is devoted to the construction of massless representations of the q-deformed Poincare algebra. In section 2 we give Hilbert space representations of the SL q (2, C)-covariant quantum space. We then show in the next section how the generators of the q-Poincare algebra can be expressed in terms of operators which live in the light cone. The q-deformed massless one-particle states are considered in section 4. (orig.)

  8. Certain Inequalities Involving the Fractional q-Integral Operators

    Directory of Open Access Journals (Sweden)

    Dumitru Baleanu

    2014-01-01

    Full Text Available We establish some inequalities involving Saigo fractional q-integral operator in the theory of quantum calculus by using the two parameters of deformation, q1 and q2, whose special cases are shown to yield corresponding inequalities associated with Riemann-Liouville and Kober fractional q-integral operators, respectively. Furthermore, we also consider their relevance with other related known results.

  9. A Search for Centrally Produced non-$ q \\bar{q} $ Mesons in Proton Proton Interactions at 450~GeV/c using the CERN $\\Omega$ Spectrometer and GAMS-4000

    CERN Multimedia

    2002-01-01

    % WA102 \\\\ \\\\ During the last decade evidence for non-$ q \\bar{q} $ mesons has grown due to experiments having high statistics in various decay modes. However there are still many channels which have promising signals but any definite conclusion is limited by the available statistics. In order to make a significant contribution to this field we propose to perform two 100~day runs combining the efficient multiphoton detection of GAMS-4000 with the good charged particle detection of the Omega Spectrometer to search for other non-$ q \\bar{q} $ mesons in the reaction $ pp \\rightarrow p _{f} X ^{o} p _{s} $ at 450~GeV/c. Although many final states will be studied those decaying to $ \\eta \\eta, \\eta \\eta ^\\prime $ and $ \\eta ^\\prime \\eta ^\\prime $ are of particular interest and the statistics in these channels will be greatly enhanced. This study will act as an important input in helping to understand non-perturbative QCD.

  10. Sobolev type spaces associated with the q-Rubin's operator

    Directory of Open Access Journals (Sweden)

    Neji Bettaibi

    2014-05-01

    Full Text Available In this paper we introduce and   study   some $q$-Sobolev type spaces by using the harmonic analysis associated with the q-Rubin operator. In particular, embedding theorems for these spaces are established.  Next, we introduce the q-Rubin potential spaces and study some of its properties.

  11. Some properties and expansions associated with the q -digamma ...

    African Journals Online (AJOL)

    This paper is devoted to derive some properties and expansions associated with the q-digamma function. The Newton series which is consisting of terms of forward difference operator, is established for the q-digamma function. The maltiplication formula of the q-gamma function is used to present some recurrence relations ...

  12. Effekt og sikkerhed af kosttilskud indeholdende Q10

    DEFF Research Database (Denmark)

    Overvad, O.K; Diamant, B; Holm, L

    1997-01-01

    The literature concerning the importance of Q10 for health and disease has been reviewed. Dietary intake together with normal in vivo synthesisseems to fulfil the body's demands for Q10 in younger, healthy individuals. The importance of Q10 in general well-being has not been investigated incontro...

  13. Q Vara likviidsusprobleem viis 4miljonilisse maksuvõlga

    Index Scriptorium Estoniae

    2007-01-01

    Kinnisvaraarendusega tegelev Q Vara võlgneb maksuametile üle nelja miljoni krooni. Ettevõtte juhi sõnul on tegemist ajutise likviidsusprobleemiga ning augusti lõpuks peaks võlg tasutud saama. Tabel: Q Vara grupi käive vähenes. Lisa: Taust. Vt. samas: Intervjuu Q Vara nõukogu esimehe Alo Lillepeaga

  14. Detuning effect study of High-Q Mobile Phone Antennas

    DEFF Research Database (Denmark)

    Bahramzy, Pevand; Pedersen, Gert F.

    2015-01-01

    Number of frequency bands that have to be covered by smart phones, are ever increasing. This broadband coverage can be obtained either by using a low-Q antenna or a high-Q tunable antenna. This study investigates high-Q antennas performance when placed in proximity of the user. This study...

  15. Q-deformed algebras and many-body physics

    Energy Technology Data Exchange (ETDEWEB)

    Galetti, D; Lunardi, J T; Pimentel, B M [Instituto de Fisica Teorica (IFT), Sao Paulo, SP (Brazil); Lima, C L [Sao Paulo Univ., SP (Brazil). Inst. de Fisica

    1995-11-01

    A review is presented of some applications of q-deformed algebras to many-body systems. The rotational and pairing nuclear problems will be discussed in the context of q-deformed algebras, before presenting a more microscopically based application of q-deformed concepts to many-fermion systems. (author). 30 refs., 5 figs.

  16. Study of structural and optical properties of ZnAlQ{sub 5} (zinc aluminum quinolate) organic phosphor for OLED applications

    Energy Technology Data Exchange (ETDEWEB)

    Nagpure, I. M., E-mail: indrajitnagpure@gmail.com; Painuly, Deepshikha [Physics, Department of Sciences and Humanities, National Institute of Technology,Uttarakhand-246174 (India); Rabanal, Maria Eugenia [Department of Materials Science and Engineering and Chemical Engineering,University Carlos III of Madrid, Avd. Universidad 30, 28911 Leganes, Madrid (Spain)

    2016-05-06

    The various composition of ZnAlQ{sub 5} such as Zn{sub 1.5}A{sub 10.5}Q{sub 5}, Zn{sub 1}Al{sub 1}Q{sub 5}, Zn{sub 0.5}Al{sub 1.5}Q{sub 5} organic phosphors were prepared via simple cost effective co-precipitation method. The FTIR, SEM, photoluminescence analysis of the prepared phosphors were reported. ZnQ{sub 2} and AlQ{sub 3} were also prepared by similar method and their properties were compared with different composition of ZnAlQ{sub 5}. The structural elucidation in the form of stretching frequencies of chemical bonds of the prepared phosphor was carried out using Fourier Transform Infrared Spectroscopy (FTIR). The stretching frequency analysis confirms the formation of prepared phosphor materials. The SEM analysis shows the surface morphological behavior of prepared phosphor materials. Greenish photoluminescence were observed at 505 to 510 nm for the different composition of ZnAlQ{sub 5},in which Zn{sub 1.5}Al{sub 0.5}Q{sub 5} shows maximum luminescence intensity at 505 nm. PL emission of ZnQ{sub 2} was observed at 515 nm, while for AlQ{sub 3} at 520 nm. The blue shift of 10 nm was observed in Zn{sub 1.5}A{sub 10.5}Q{sub 5} due to modification of energy level due to presence of Zn{sup 2+} and Al{sup 3+}. The enhancement in PL intensity was observed in Zn{sub 1.5}A{sub 10.5}Q{sub 5} compared to the other composition due to transfer of energy between Zn{sup 2+} and quinolate complex. Optical properties of the prepared materials were evaluated for possible applications in organic light emitting devices (OLED).

  17. Deletion of 7q33-q35 in a Patient with Intellectual Disability and Dysmorphic Features: Further Characterization of 7q Interstitial Deletion Syndrome

    Directory of Open Access Journals (Sweden)

    Kristen Dilzell

    2015-01-01

    Full Text Available This case report concerns a 16-year-old girl with a 9.92 Mb, heterozygous interstitial chromosome deletion at 7q33-q35, identified using array comparative genomic hybridization. The patient has dysmorphic facial features, intellectual disability, recurrent infections, self-injurious behavior, obesity, and recent onset of hemihypertrophy. This patient has overlapping features with previously reported individuals who have similar deletions spanning the 7q32-q36 region. It has been difficult to describe an interstitial 7q deletion syndrome due to variations in the sizes and regions in the few patients reported in the literature. This case contributes to the further characterization of an interstitial distal 7q deletion syndrome.

  18. Q-value effects in the synthesis of superheavy elements

    International Nuclear Information System (INIS)

    Graeger, Reimar

    2010-01-01

    Superheavy elements (Z>or similar 104) only exist due to nuclear shell effects, which stabilize them against spontaneous fission (SF). Theoretical calculations predict these shell stabilization effects to reach a maximum at the closures of the next spherical proton and neutron shells, which are anticipated in the region between Z=114 and Z=126 and at N=184. More recent calculations, that also consider deformed nuclear shapes extended this picture and predicted deformed shell closures at Z=108 and at N=162, creating a region of enhanced stability around 270 Hs, confirmed in recent Hs chemistry experiments by measuring the decay of 270 Hs for the first time. Recently, the formation of deformed doubly-magic 270 Hs in the 4n evaporation channel in the fusion reactions 248 Cm( 26 Mg,4n), 244 Pu( 30 Si,4n), 238 U( 36 S,4n), and 226 Ra( 48 Ca,4n) was studied theoretically using a two-parameter Smoluchowski equation. Simple entrance channel arguments make compound nucleus (CN) formation appear favorable for systems with larger mass asymmetry. However, due to a lower reaction Q value, the reactions 238 U( 36 S,4n) 270 Hs and 226 Ra( 48 Ca,4n) 270 Hs are predicted to have higher cross sections compared to the reactions 248 Cm( 26 Mg,4n) 270 Hs and 244 Pu( 30 Si,4n) 270 Hs. The aim of the research done in the framework of this thesis was to study the influence of the reaction (B-Q)-value on the yield of SHE produced in nuclear fusion reactions. Therefore the most promising reactions 36 S+ 238 U and 48 Ca+ 226 Ra have been investigated and compared with the already measured reaction 26 Mg+ 248 Cm. The reaction 36 S+ 238 U was investigated at two beam energies. One correlated decay chain attributed to 270 Hs was found at E * =51 MeV resulting in a cross section of 0.8 -0.7 +2.6 pb. The reaction 48 Ca+ 226 Ra was investigated at three beam energies. Six correlated decay chains attributed to 270 Hs were detected at E * =40 MeV corresponding to a cross section of 8.3 -3.7 +6.7 pb

  19. Comparison of V/Q SPECT and planar V/Q lung scintigraphy in diagnosing acute pulmonary embolism

    DEFF Research Database (Denmark)

    Borgwardt, Henrik Gutte; Mortensen, Jann; Jensen, Claus Verner

    2010-01-01

    Planar ventilation/perfusion (V/Q) scintigraphy is currently the standard method for the diagnosis of pulmonary embolism (PE) in most nuclear medicine centers. However, recent studies have shown a superior sensitivity and specificity when applying V/Q single photon emission computed tomography...... (SPECT) in diagnosing PE. This study evaluated the diagnostic performance of three-dimensional V/Q SPECT in comparison with planar V/Q scintigraphy....

  20. On q-analogues of the Mangontarum transform for certain q-Bessel functions and some application

    Directory of Open Access Journals (Sweden)

    S.K.Q. Al-Omari

    2016-10-01

    Full Text Available Several q-analogues of certain integral transforms have been recently investigated by many authors in the recent past. In this paper, we introduce certain analogues of the so-called q-Mangontarum transform and implement the proposed variants to given classes of q-Bessel functions. The results of this paper are new and complement the previously known results of Mangontarum (2014. Some results related to q-Laplace transforms are also obtained.

  1. Interstitial deletion of 5q33.3q35.1 in a boy with severe mental retardation

    OpenAIRE

    Lee, Jin Hwan; Kim, Hyo Jeong; Yoon, Jung Min; Cheon, Eun Jung; Lim, Jae Woo; Ko, Kyong Og; Lee, Gyung Min

    2016-01-01

    Constitutional interstitial deletions of the long arm of chromosome 5 (5q) are quite rare, and the corresponding phenotype is not yet clearly delineated. Severe mental retardation has been described in most patients who present 5q deletions. Specifically, the interstitial deletion of chromosome 5q33.3q35.1, an extremely rare chromosomal aberration, is characterized by mental retardation, developmental delay, and facial dysmorphism. Although the severity of mental retardation varies across cas...

  2. High-Q plasmonic bottle microresonator

    Science.gov (United States)

    Mohd Nasir, M. Narizee; Ding, Ming; Murugan, G. Senthil; Zervas, Michalis N.

    2014-03-01

    In this paper, we demonstrate a hybrid plasmonic bottle microresonator (PBMR) which supports whispering gallery modes (WGMs) along with surface plasmon waves (SPWs) for high performance optical sensor applications. The BMR was fabricated through "soften-and-compress" technique with a thin gold layer deposited on top of the resonator. A polarization-resolved measurement was set-up in order to fully characterize the fabricated PBMR. Initially, the uncoated BMR with waist diameter of 181 μm, stem diameter of 125 μm and length of 400 μm was fabricated and then gold film was deposited on the surface. Due to surface curvature, the gold film covering half of the BMR had a characteristic meniscus shape and maximum thickness of 30 nm. The meniscus provides appropriately tapered edges which facilitate the adiabatic transformation of BMR WGMs to SPWs and vice versa. This results in low transition losses, which combined with partially-metal-coated resonator, can result in high hybrid-PBMR Q's. The transmission spectra of the hybrid PBMR are dramatically different to the original uncoated BMR. Under TE(TM) excitation, the PBMR showed composite resonances with Q of ~2100(850) and almost identical ~ 3 nm FSR. We have accurately fitted the observed transmission resonances with Lorentzian-shaped curves and showed that the TE and TM excitations are actually composite resonances comprise of two and three partially overlapping resonances with Q's in excess of 2900 and 2500, respectively. To the best of our knowledge these are the highest Qs observed in plasmonic microcavities.

  3. The q-G method : A q-version of the Steepest Descent method for global optimization.

    Science.gov (United States)

    Soterroni, Aline C; Galski, Roberto L; Scarabello, Marluce C; Ramos, Fernando M

    2015-01-01

    In this work, the q-Gradient (q-G) method, a q-version of the Steepest Descent method, is presented. The main idea behind the q-G method is the use of the negative of the q-gradient vector of the objective function as the search direction. The q-gradient vector, or simply the q-gradient, is a generalization of the classical gradient vector based on the concept of Jackson's derivative from the q-calculus. Its use provides the algorithm an effective mechanism for escaping from local minima. The q-G method reduces to the Steepest Descent method when the parameter q tends to 1. The algorithm has three free parameters and it is implemented so that the search process gradually shifts from global exploration in the beginning to local exploitation in the end. We evaluated the q-G method on 34 test functions, and compared its performance with 34 optimization algorithms, including derivative-free algorithms and the Steepest Descent method. Our results show that the q-G method is competitive and has a great potential for solving multimodal optimization problems.

  4. On a q-extension of Mehta's eigenvectors of the finite Fourier transform for q a root of unity

    OpenAIRE

    Atakishiyeva, Mesuma K.; Atakishiyev, Natig M.; Koornwinder, Tom H.

    2008-01-01

    It is shown that the continuous q-Hermite polynomials for q a root of unity have simple transformation properties with respect to the classical Fourier transform. This result is then used to construct q-extended eigenvectors of the finite Fourier transform in terms of these polynomials.

  5. q-Extension of Mehta's eigenvectors of the finite Fourier transform for q, a root of unity

    NARCIS (Netherlands)

    Atakishiyeva, M.K.; Atakishiyev, N.M.; Koornwinder, T.H.

    2009-01-01

    It is shown that the continuous q-Hermite polynomials for q, a root of unity, have simple transformation properties with respect to the classical Fourier transform. This result is then used to construct q-extended eigenvectors of the finite Fourier transform in terms of these polynomials.

  6. Deletions at chromosome regions 7q11.23 and 7q36 in a patient with Williams syndrome

    NARCIS (Netherlands)

    Wouters, C. H.; Meijers-Heijboer, H. J.; Eussen, B. J.; van der Heide, A. A.; van Luijk, R. B.; van Drunen, E.; Beverloo, B. B.; Visscher, F.; van Hemel, J. O.

    2001-01-01

    We report on a patient with Williams syndrome and a complex de novo chromosome rearrangement, including microdeletions at 7q11.23 and 7q36 and additional chromosomal material at 7q36. The nature of this additional material was elucidated by spectral karyotyping and first assigned to chromosome 22.

  7. [Q fever. Description of a case].

    Science.gov (United States)

    Peña-Irún, Á; González Santamaría, A R; Munguía Rozadilla, F; Herrero González, J L

    2013-01-01

    Q fever is a zoonosis of global distribution with an incidence of 3 cases per 100,000 inhabitants/year. A variety of animals can be the coxiella reservoir which always must be taken into account when faced with a fever process in a compatible context. Rapid diagnosis and treatment are essential to improve the prognosis, and prevent the development of chronic infection or other potential complications associated with the coxelliosis. Copyright © 2012 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España. All rights reserved.

  8. Oscillators in resonance p:q:r

    International Nuclear Information System (INIS)

    Arribas, M.; Elipe, A.; Floria, L.; Riaguas, A.

    2006-01-01

    A canonical transformation is proposed to handle Hamiltonian systems made of the addition or subtraction of three harmonic oscillators in p:q:r resonance. This transformation is an extension of the classical Lissajous transformation for the 1:1 resonance. Our extended Lissajous variables consist of three pairs of action-angle variables, which makes possible the application of perturbation theories without encountering small divisors. A set of functions, related with the Lissajous variables, are found, and are used to describe the phase flow of reduced space after normalization

  9. Overview of LANL and ESH&Q

    Energy Technology Data Exchange (ETDEWEB)

    Dutro, Cynthia L [Los Alamos National Laboratory

    2011-01-13

    ESH&Q FY11 objectives are to: (1) Clearly define the ESH&O standards and requirements for institutional programs to ensure compliance with contractual and regulatory requirements, and communicate the relevant requirements, including specific work activities and associated priorities that must be completed, to LANL Organizations; (2) Provide qualified ESH&O subject matter expertise, training support, centralized and deployed services, tools, and procedures to meet both internal customer needs and institutional operational requirements, subject to institutional funding; and (3) Provide support to the Laboratory to meet operational commitments and performance goals.

  10. Visual Pretraining for Deep Q-Learning

    OpenAIRE

    Sandven, Torstein

    2016-01-01

    Recent advances in reinforcement learning enable computers to learn human level polices for Atari 2600 games. This is done by training a convolutional neural network to play based on screenshots and in-game rewards. The network is referred to as a deep Q-network (DQN). The main disadvantage to this approach is a long training time. A computer will typically learn for approximately one week. In this time it processes 38 days of game play. This thesis explores the possibility of using visual pr...

  11. Q stands for a big question

    International Nuclear Information System (INIS)

    McBarnet, Andrew

    2000-01-01

    This article reports on the launch of the Schlumberger's Q-Marine approach to seismic imaging and the almost simultaneous establishment of Western Geco from the merged Western Geophysical and Schlumberger's Geco-Prakla, and examines the effects of these activities on the seismic data acquisition market. Details are given of the ability to carry out repeated 3-dimensional seismic surveys over a reservoir during production using conventional streamer acquisition allowing in effect 4-dimensional reservoir monitoring. The on-board computer processing systems, the streamer steering system, and the collection of accurate high resolution data are discussed

  12. Bioavailability of four oral Coenzyme Q formulations in healthy volunteers

    DEFF Research Database (Denmark)

    Weis, M.; Mortensen, S.A.; Rassing, M.R.

    1994-01-01

    The bioavailability of four different Coenzyme Q (CoQ) formulations was compared in ten healthy volunteers in a four-way randomised cross-over trial. The included formulations were: A hard gelatine capsule containing 100 mg of CoQ and 400 mg of Emcompress. Three soft gelatine capsules containing......Q (Bioquinon has the highest bioavailability. A difference in basic AUC and AUC after p.o.administration of CoQ was observed with respect to sex. A characteristic two peak-pattern was observed at the concentration-time profile....

  13. On Recursion Operator of the q -KP Hierarchy

    International Nuclear Information System (INIS)

    Tian Ke-Lei; Zhu Xiao-Ming; He Jing-Song

    2016-01-01

    It is the aim of the present article to give a general expression of flow equations of the q-KP hierarchy. The distinct difference between the q-KP hierarchy and the KP hierarchy is due to q-binomial and the action of q-shift operator θ, which originates from the Leibnitz rule of the quantum calculus. We further show that the n-reduction leads to a recursive scheme for these flow equations. The recursion operator for the flow equations of the q-KP hierarchy under the n-reduction is also derived. (paper)

  14. Some aspects of q- and qp- boson calculus

    International Nuclear Information System (INIS)

    Kibler, M.R.; Asherova, R.M.; Smirnov, Y.F.

    1994-10-01

    A set of compatible formulas for the Clebsch-Gordan coefficients of the quantum algebra U q (su 2 ) is given in this paper. These formulas are q-deformations of known formulas, as for instance: Wigner, van der Waerden, and Racah formulas. They serve as starting points for deriving various realizations of the unit tensor of U q (su 2 ) in terms of q-boson operators. the passage from the one-parameter quantum algebra U q (su 2 ) to the two-parameter quantum algebra U qp (u 2 ) is discussed at the level of Clebsch-Gordan coefficients. (authors)

  15. A Case with 46,XX,dup(X(q21.3q24 karyotype

    Directory of Open Access Journals (Sweden)

    Selda Şimşek

    2010-03-01

    Full Text Available The relationship between phenotype and Xq duplicationsin females remains unclear. Some females are normal;some have short stature; and others have features suchas microcephaly, developmental delay/mental retardation,body asymmetries, and gonadal dysgenesis. Somefeatures in these females resemble those in Turner syndrome.We, herein, presented a 15 years-old girl withshort stature and primary amenorrhea, who was referredto cytogenetic laboratory. Through karyotipe analysis performedby Giemsa banding technique, the patient wasdetermined to have positive Barr body and 46,XX,dup(X(q21.3q24 chromosomal constitution. Case was discussedaccording to information of present literatures.

  16. Planetary Candidates Observed by Kepler IV: Planet Sample from Q1-Q8 (22 Months)

    OpenAIRE

    Burke, Christopher J.; Christensen, Jessie L.; Ciardi, David R.; Morton, Timothy D.; Shporer, Avi

    2014-01-01

    We provide updates to the Kepler planet candidate sample based upon nearly two years of high-precision photometry (i.e., Q1-Q8). From an initial list of nearly 13,400 threshold crossing events, 480 new host stars are identified from their flux time series as consistent with hosting transiting planets. Potential transit signals are subjected to further analysis using the pixel-level data, which allows background eclipsing binaries to be identified through small image position shifts during tra...

  17. Detailed structure of the q profile around q=1 in JET

    International Nuclear Information System (INIS)

    Pegourie, B.; Dubois, M.A.; Gill, R.D.

    1989-01-01

    The limitation of ablation on rational surfaces has been shown to be an efficient mechanism of striation formation during pellet ablation. In JET, a very large striation is observed when the pellet crosses the q=1 surface. This paper presents a thorough analysis of the pellet ablation in this region and shows that an extended shearless zone around q=1 is necessary to reproduce the experimental signal. Such a feature is likely to be an essential ingredient in the understanding of internal disruptions. (author) 4 refs., 2 figs

  18. Improving attenuation tomography by novel inversions for t* and Q: application to Parkfield, California and Okmok volcano, Alaska

    Science.gov (United States)

    Pesicek, J. D.; Bennington, N. L.; Thurber, C. H.; Zhang, H.

    2011-12-01

    traditional inversion techniques to illustrate enhancements to the Q models.

  19. q-Generalization of the inverse Fourier transform

    International Nuclear Information System (INIS)

    Jauregui, M.; Tsallis, C.

    2011-01-01

    A wide class of physical distributions appears to follow the q-Gaussian form, which plays the role of attractor according to a q-generalized Central Limit Theorem, where a q-generalized Fourier transform plays an important role. We introduce here a method which determines a distribution from the knowledge of its q-Fourier transform and some supplementary information. This procedure involves a recently q-generalized representation of the Dirac delta and the class of functions on which it acts. The present method conveniently extends the inverse of the standard Fourier transform, and is therefore expected to be very useful in the study of many complex systems. - Highlights: → We present a method to invert the q-Fourier transform of a distribution. → We illustrate when Dirac delta can be represented using q-exponentials. → We describe a family of functions for which this new representation works.

  20. Molecular analysis of Hb Q-H disease and Hb Q-Hb E in a Singaporean family.

    Science.gov (United States)

    Tan, J; Tay, J S; Wong, Y C; Kham, S K; Bte Abd Aziz, N; Teo, S H; Wong, H B

    1995-01-01

    Hb Q (alpha 74Asp-His) results from a mutation in the alpha-gene such that abnormal alpha Q-chains are synthesized. The alpha Q-chains combine with the normal Beta A-chains to form abnormal Hb alpha 2Q beta 2A (Hb Q). Hb Q-H disease is rare, and has been reported only in the Chinese. We report here a Chinese family, were the mother diagnosed with Hb Q-H disease and the father with Hb E heterozygosity and a child with Hb Q-E-thalassemia. Thalassemia screening of the mother's blood revealed a Hb level of 6.8g/dl with low MCV and MCH. Her blood film was indicative of thalassemia. Cellulose acetate electrophoresis showed Hb H and Hb Q with the absence of Hb A. Globin chain biosynthesis was carried out and alpha Q- and beta-chains were detected. Normal alpha- chains were absent. Digestion of the mother's DNA with Bam HI and Bgl II followed by hybridization with the 1.5 kb alpha-Pst probe showed a two alpha-gene deletion on one chromosome and the -alpha Q chain mutant with the -alpha 4.2 defect on the other chromosome. DNA amplification studies indicated the two-gene deletion to be of the -SEA/ defect. The patient was concluded to possess Hb Q-H disease (--SEA/-alpha 4.2Q). Cellulose acetate electrophoresis of the father's blood showed the presence of Hb A, F and E. Molecular analysis of the father's DNA confirmed an intact set of alpha-genes (alpha alpha/alpha alpha). Globin chain biosynthesis of fetal blood of their child showed gamma, beta A, beta E, alpha A and alpha Q-chains. Molecular analysis of the child's DNA showed one alpha-gene deletion, thus giving a genotype of alpha alpha/-alpha 4.2Q beta beta E.

  1. q-Strategy spatial prisoner's dilemma game

    International Nuclear Information System (INIS)

    Li, Zhi-Hua; Fan, Hong-Yi; Xu, Wen-Long; Yang, Han-Xin

    2011-01-01

    We generalize the usual two-strategy prisoner's dilemma game to a multi-strategy game, in which the strategy variable s is allowed to take q different fractional values lying between 0 and 1. The fractional-valued strategies signify that individuals are not absolutely cooperative or defective, instead they can adopt intermediate strategies. Simulation results on 1D and 2D lattices show that, compared with the binary strategy game, the multi-strategy game can sustain cooperation in more stringent defective environments. We give a comprehensive analysis of the distributions of the survived strategies and we compare pairwise the relative strength and weakness of different strategies. It turns out that some intermediate strategies survive the pure defection because they can reduce being exploited and at the same time benefit from the spatial reciprocity effect. Our work may shed some light on the intermediate behaviors in human society. -- Highlights: → We propose a q-strategy prisoner's dilemma game with intermediate strategies. → The intermediate strategies characterize the extent of cooperation or defection. → We implement the model in a structured population. → The intermediate strategies can promote cooperation.

  2. The power of q a personal journey

    CERN Document Server

    Hirschhorn, Michael D

    2017-01-01

    This unique book explores the world of q, known technically as basic hypergeometric series, and represents the author’s personal and life-long study—inspired by Ramanujan—of aspects of this broad topic. While the level of mathematical sophistication is graduated, the book is designed to appeal to advanced undergraduates as well as researchers in the field. The principal aims are to demonstrate the power of the methods and the beauty of the results. The book contains novel proofs of many results in the theory of partitions and the theory of representations, as well as associated identities. Though not specifically designed as a textbook, parts of it may be presented in course work; it has many suitable exercises. After an introductory chapter, the power of q-series is demonstrated with proofs of Lagrange’s four-squares theorem and Gauss’s two-squares theorem. Attention then turns to partitions and Ramanujan’s partition congruences. Several proofs of these are given throughout the book. Many chapter...

  3. A reliable and feasible qPCR strategy for titrating AAV vectors.

    Science.gov (United States)

    Wang, Feng; Cui, Xiuling; Wang, Mingxi; Xiao, Weidong; Xu, Ruian

    2013-07-05

    Previous studies have revealed that traditional real-time quantitative PCR (qPCR) underestimates adeno-associated virus (AAV) titer. Because the inverted terminal repeat (ITR) exists in all AAV vectors, the only remaining element from the wild genome could form special configurations to interfere with qPCR titration. To solve this problem, a modified and universal qPCR method was tested and established. In this work, there was a great variation in titration of ssAAV2-EGFP (Enhanced Green Fluorescence Protein) and scAAV2-EGFP genome by traditional qPCR. For ssAAV2-EGFP, the highest titer was found by using the targeting EGFP primers and the lowest titer was measured by those targeting bovine growth hormone polyA element (pBGH) primers. Experimental data were reverse for ssAAV2-EGFP and scAAV2-EGFP. Here we report an improved and universal SmaI qPCR method, based on cleaving all ITRs in AAV2 genome by SmaI with several advantages: (1) impact of all ITRs in ssAAV2 and scAAV2 was dismissed; (2) titers increased remarkably, up to 7-fold, especially for scAAV2; (3) the variation of titers was reduced when different primers were applied. A similar phenomenon was also observed in other ssAAV2 and scAAV2 products when the range of titration was at 3×107 to 7×109 V.G/µl in this study. This modified qPCR strategy can increase rAAV' titer and reduce titration variance, possibly become a universal method for titrating AAV vectors.

  4. Replication the association of 2q32.2-q32.3 and 14q32.11 with hepatocellular carcinoma.

    Science.gov (United States)

    Chen, Wei; Wang, Mingquan; Zhang, Zhen; Tang, Huayang; Zuo, Xianbo; Meng, Xiangling; Xiong, Maoming; Zhou, Fusheng; Liang, Bo; Dai, Fen; Fang, Jun; Gao, Jinping; Zhu, Jun; Zhu, Yong; Wan, Hong; Wang, Miaofeng; Chan, Shixin; Sun, Liangdan

    2015-04-25

    Hepatocellular carcinoma (HCC) is a malignant tumor. The morbidity and mortality of HCC tend to ascend and become a serious threat to the population health. Genetic studies of HCC have identified several susceptibility loci of HCC. In this study, we aim to replicate the association of these loci in our samples from Chinese population and further investigate the genetic interaction. We selected 16 SNPs within 1p36.22, 2q32.2-q32.3, 3p21.33, 8p12, 14q32.11 and 21q21.3 and genotyped in 507 HCC patients and 3014 controls by using Sequenom MassARRAY system. Association analyses were performed by using PLINK 1.07. We observed that the STAT4 (2q32.2-q32.3) at rs7574865 (P=1.17×10(-3), OR=0.79) and EFCAB11 (14q32.11) at rs8013403 (P=1.54×10(-3), OR=0.80) were significantly associated with HCC in this study. In 3p21.33, genetic variant rs6795737 within GLB1 was also observed with suggestive evidence (P=9.98×10(-3), OR=0.84). In the interaction analysis, the pair of associated SNPs (rs7574865 within STAT4, rs8013403 within EFCAB11) generated evidence for interaction (P=4.10×10(-3)). In summary, our work first reported the association of 14q32.11 (EFCAB11) with HCC in Chinese Han population and revealed the genetic interaction between STAT4 (2q32.2-q32.3) and EFCAB11 (14q32.11) in HCC. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Meta-metallic coils and resonators: Methods for high Q-value resonant geometries

    Energy Technology Data Exchange (ETDEWEB)

    Mett, R. R. [Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States); Department of Physics and Chemistry, Milwaukee School of Engineering, Milwaukee, Wisconsin 53202 (United States); Sidabras, J. W.; Hyde, J. S. [Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 (United States)

    2016-08-15

    A novel method of decreasing ohmic losses and increasing Q-value in metallic resonators at high frequencies is presented. The method overcomes the skin-depth limitation of rf current flow cross section. The method uses layers of conductive foil of thickness less than a skin depth and capacitive gaps between layers. The capacitive gaps can substantially equalize the rf current flowing in each layer, resulting in a total cross-sectional dimension for rf current flow many times larger than a skin depth. Analytic theory and finite-element simulations indicate that, for a variety of structures, the Q-value enhancement over a single thick conductor approaches the ratio of total conductor thickness to skin depth if the total number of layers is greater than one-third the square of the ratio of total conductor thickness to skin depth. The layer number requirement is due to counter-currents in each foil layer caused by the surrounding rf magnetic fields. We call structures that exhibit this type of Q-enhancement “meta-metallic.” In addition, end effects due to rf magnetic fields wrapping around the ends of the foils can substantially reduce the Q-value for some classes of structures. Foil structures with Q-values that are substantially influenced by such end effects are discussed as are five classes of structures that are not. We focus particularly on 400 MHz, which is the resonant frequency of protons at 9.4 T. Simulations at 400 MHz are shown with comparison to measurements on fabricated structures. The methods and geometries described here are general for magnetic resonance and can be used at frequencies much higher than 400 MHz.

  6. Trisomy 2q11.2-->q21.1 resulting from an unbalanced insertion in two generations.

    Science.gov (United States)

    Glass, I A; Stormer, P; Oei, P T; Hacking, E; Cotter, P D

    1998-01-01

    In this communication, we describe two cases of proximal 2q trisomy (2q11.2--> q21.1) resulting from an interchromosomal insertion. The chromosomal origin of the insertion was confirmed by fluorescence in situ hybridisation. An unbalanced karyotype, 46,XX,der(8) ,ins(8;2) (p21.3; q21.1q11.2), was found in the proband and her mother, who both have mild mental retardation, short stature, dysmorphic features, insulin dependent diabetes mellitus, and a psychotic illness. This family is a rare example of direct transmission of a partial autosomal trisomy. Images PMID:9598728

  7. Kepler Stellar Properties Catalog Update for Q1-Q17 DR25 Transit Search

    Science.gov (United States)

    Mathur, Savita; Huber, Daniel

    2016-01-01

    Huber et al. (2014) presented revised stellar properties for 196,468 Kepler targets, which were used for the Q1-Q16 TPSDV planet search (Tenenbaum et al. 2014). The catalog was based on atmospheric properties (i.e., temperature (Teff), surface gravity (log(g)), and metallicity ([FeH])) published in the literature using a variety of methods (e.g., asteroseismology, spectroscopy, exoplanet transits, photometry), which were then homogeneously fitted to a grid of Dartmouth (DSEP) isochrones (Dotter et al. 2008). The catalog was updated in early 2015 for the Q1-Q17 Data Release (DR) 24 transit search (Seader et al. 2015) based on the latest classifications of Kepler targets in the literature at that time. The methodology followed Huber et al. (2014). Here we provide updated stellar properties of 197,096 Kepler targets. Like the previous catalog, this update is based on atmospheric properties that were either published in the literature or provided by the Kepler community follow-up program (CFOP). The input values again come from different methods: asteroseismology, spectroscopy, flicker, and photometry. This catalog update was developed to support the SOC 9.3 TPSDV planet search (Twicken et al. 2016), which is expected to be the final search and data release by the Kepler project.In this document, we describe the method and the inputs that were used to build the catalog. The methodology follows Huber et al. (2014) with a few improvements as described in Section 2.

  8. Water-soluble coenzyme Q10 formulation (Q-TER(®)) in the treatment of presbycusis.

    Science.gov (United States)

    Salami, Angelo; Mora, Renzo; Dellepiane, Massimo; Manini, Giorgio; Santomauro, Valentina; Barettini, Luciano; Guastini, Luca

    2010-10-01

    These preliminary data are encouraging for a larger clinical trial to collect additional evidence on the effect of Q-TER(®) in preventing the development of hearing loss in subjects with presbycusis. The purpose of this study was to evaluate the efficiency and applicability of a water-soluble formulation of CoQ10 (Q-TER(®)) in subjects with presbycusis. A total of 60 patients with presbycusis were included and divided into three numerically equal groups. Group A underwent therapy with Q-TER(®), 160 mg, once a day for 30 days; group B underwent therapy with vitamin E (50 mg), once a day for 30 days; group C received placebo, once a day for 30 days. Before and at the end of the treatment, all patients underwent pure tone audiometry, transient evoked otoacoustic emissions, otoacoustic products of distortion, auditory brainstem response, and speech audiometry. Compared with group B, at the end of the treatment in group A the liminar tonal audiometry showed a significant improvement of the air and bone thresholds at the 1000 (14/20 vs 9/20), 2000 (14/20 vs 7/20), 4000 (15/20 vs 6/20), and 8000 Hz (13/20 vs 5/20). We found no significant differences in the other parameters and in group C.

  9. The q-Onsager algebra and multivariable q-special functions

    Science.gov (United States)

    Baseilhac, Pascal; Vinet, Luc; Zhedanov, Alexei

    2017-09-01

    Two sets of mutually commuting q-difference operators x i and y j , i,j=1,...,N such that x i and y i generate a homomorphic image of the q-Onsager algebra for each i are introduced. The common polynomial eigenfunctions of each set are found to be entangled product of elementary Pochhammer functions in N variables and N+3 parameters. Under certain conditions on the parameters, they form two ‘dual’ bases of polynomials in N variables. The action of each operator with respect to its dual basis is block tridiagonal. The overlap coefficients between the two dual bases are expressed as entangled products of q-Racah polynomials and satisfy an orthogonality relation. The overlap coefficients between either one of these bases and the multivariable monomial basis are also considered. One obtains in this case entangled products of dual q-Krawtchouk polynomials. Finally, the ‘split’ basis in which the two families of operators act as block bidiagonal matrices is also provided.

  10. q-Karamata functions and second order q-difference equations

    Czech Academy of Sciences Publication Activity Database

    Řehák, Pavel; Vítovec, J.

    -, č. 24 (2011), s. 1-20 ISSN 1417-3875 Institutional research plan: CEZ:AV0Z10190503 Keywords : regularly varying functions * rapidly varying functions * q-difference equations Subject RIV: BA - General Mathematics Impact factor: 0.557, year: 2011

  11. Cultural stereotyping of the lady in 4Q184 and 4Q185

    Directory of Open Access Journals (Sweden)

    Ananda Geyser-Fouché

    2016-10-01

    Full Text Available Wisdom and wickedness as a ‘Woman’ have always attracted much discussion, especially in the ways images of the female are employed in wisdom literature. This article focuses on two Qumran texts that fall into the category of wisdom literature, namely 4Q184 and 4Q185, and the metaphorical appropriation of the woman as a figure of wisdom or a figure of wickedness. By combining a number of traditions in certain forms, sages tried to establish an education for their learners on how to obtain wisdom with the ultimate purpose of creating harmony. The ultimate purpose of the wisdom teachings of the sages was to confirm the harmony in the universe, and these teachings were also conveyed to their learners. In their instructions, they often employed binary opposites such as ‘wise’ and ‘fool’ according to which someone was characterised, or rather stereotyped. The result of such binary stereotyping was that the ‘whore’ and the ‘holy one’ represented opposite poles, and became fixed images in Judaism. According to feminist exegetes, these images typify the concept of cultural stereotyping. This article aims to illustrate that two Qumran texts, 4Q184 and 4Q185, regarded as wisdom texts, employ the female stereotypes that were known in the wisdom literature of Judaism.

  12. Cultural stereotyping of the lady in 4Q184 and 4Q185

    Directory of Open Access Journals (Sweden)

    Ananda Geyser-Fouché

    2016-05-01

    Full Text Available Wisdom and wickedness as a ‘Woman’ have always attracted much discussion, especially in the ways images of the female are employed in wisdom literature. This article focuses on two Qumran texts that fall into the category of wisdom literature, namely 4Q184 and 4Q185, and the metaphorical appropriation of the woman as a figure of wisdom or a figure of wickedness. By combining a number of traditions in certain forms, sages tried to establish an education for their learners on how to obtain wisdom with the ultimate purpose of creating harmony. The ultimate purpose of the wisdom teachings of the sages was to confirm the harmony in the universe, and these teachings were also conveyed to their learners. In their instructions, they often employed binary opposites such as ‘wise’ and ‘fool’ according to which someone was characterised, or rather stereotyped. The result of such binary stereotyping was that the ‘whore’ and the ‘holy one’ represented opposite poles, and became fixed images in Judaism. According to feminist exegetes, these images typify the concept of cultural stereotyping. This article aims to illustrate that two Qumran texts, 4Q184 and 4Q185, regarded as wisdom texts, employ the female stereotypes that were known in the wisdom literature of Judaism.

  13. PLANETARY CANDIDATES OBSERVED BY KEPLER IV: PLANET SAMPLE FROM Q1-Q8 (22 MONTHS)

    International Nuclear Information System (INIS)

    Burke, Christopher J.; Mullally, F.; Rowe, Jason F.; Thompson, Susan E.; Coughlin, Jeffrey L.; Caldwell, Douglas A.; Jenkins, Jon M.; Bryson, Stephen T.; Haas, Michael R.; Batalha, Natalie M.; Borucki, William J.; Christiansen, Jessie L.; Ciardi, David R.; Still, Martin; Barclay, Thomas; Chaplin, William J.; Clarke, Bruce D.; Cochran, William D.; Demory, Brice-Olivier; Esquerdo, Gilbert A.

    2014-01-01

    We provide updates to the Kepler planet candidate sample based upon nearly two years of high-precision photometry (i.e., Q1-Q8). From an initial list of nearly 13,400 threshold crossing events, 480 new host stars are identified from their flux time series as consistent with hosting transiting planets. Potential transit signals are subjected to further analysis using the pixel-level data, which allows background eclipsing binaries to be identified through small image position shifts during transit. We also re-evaluate Kepler Objects of Interest (KOIs) 1-1609, which were identified early in the mission, using substantially more data to test for background false positives and to find additional multiple systems. Combining the new and previous KOI samples, we provide updated parameters for 2738 Kepler planet candidates distributed across 2017 host stars. From the combined Kepler planet candidates, 472 are new from the Q1-Q8 data examined in this study. The new Kepler planet candidates represent ∼40% of the sample with R P ∼ 1 R ⊕ and represent ∼40% of the low equilibrium temperature (T eq < 300 K) sample. We review the known biases in the current sample of Kepler planet candidates relevant to evaluating planet population statistics with the current Kepler planet candidate sample

  14. New q-ary quantum MDS codes with distances bigger than q/2

    Science.gov (United States)

    He, Xianmang; Xu, Liqing; Chen, Hao

    2016-07-01

    The construction of quantum MDS codes has been studied by many authors. We refer to the table in page 1482 of (IEEE Trans Inf Theory 61(3):1474-1484, 2015) for known constructions. However, there have been constructed only a few q-ary quantum MDS [[n,n-2d+2,d

  15. Impact of Chemical Analogs of 4-Hydroxybenzoic Acid on Coenzyme Q Biosynthesis: From Inhibition to Bypass of Coenzyme Q Deficiency

    Directory of Open Access Journals (Sweden)

    Fabien Pierrel

    2017-06-01

    Full Text Available Coenzyme Q is a lipid that participates to important physiological functions. Coenzyme Q is synthesized in multiple steps from the precursor 4-hydroxybenzoic acid. Mutations in enzymes that participate to coenzyme Q biosynthesis result in primary coenzyme Q deficiency, a type of mitochondrial disease. Coenzyme Q10 supplementation of patients is the classical treatment but it shows limited efficacy in some cases. The molecular understanding of the coenzyme Q biosynthetic pathway allowed the design of experiments to bypass deficient biosynthetic steps with analogs of 4-hydroxybenzoic acid. These molecules provide the defective chemical group and can reactivate endogenous coenzyme Q biosynthesis as demonstrated recently in yeast, mammalian cell cultures, and mouse models of primary coenzyme Q deficiency. This mini review presents how the chemical properties of various analogs of 4-hydroxybenzoic acid dictate the effect of the molecules on CoQ biosynthesis and how the reactivation of endogenous coenzyme Q biosynthesis may achieve better results than exogenous CoQ10 supplementation.

  16. Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1

    Science.gov (United States)

    Cai, Qiuyin; Zhang, Ben; Sung, Hyuna; Low, Siew-Kee; Kweon, Sun-Seog; Lu, Wei; Shi, Jiajun; Long, Jirong; Wen, Wanqing; Choi, Ji-Yeob; Noh, Dong-Young; Shen, Chen-Yang; Matsuo, Keitaro; Teo, Soo-Hwang; Kim, Mi Kyung; Khoo, Ui Soon; Iwasaki, Motoki; Hartman, Mikael; Takahashi, Atsushi; Ashikawa, Kyota; Matsuda, Koichi; Shin, Min-Ho; Park, Min Ho; Zheng, Ying; Xiang, Yong-Bing; Ji, Bu-Tian; Park, Sue K.; Wu, Pei-Ei; Hsiung, Chia-Ni; Ito, Hidemi; Kasuga, Yoshio; Kang, Peter; Mariapun, Shivaani; Ahn, Sei Hyun; Kang, Han Sung; Chan, Kelvin Y. K.; Man, Ellen P. S.; Iwata, Hiroji; Tsugane, Shoichiro; Miao, Hui; Liao, Jiemin; Nakamura, Yusuke; Kubo, Michiaki; Delahanty, Ryan J.; Zhang, Yanfeng; Li, Bingshan; Li, Chun; Gao, Yu-Tang; Shu, Xiao-Ou; Kang, Daehee; Zheng, Wei

    2014-01-01

    In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified three novel genetic loci associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene, P = 8.82 × 10−9), rs10474352 at 5q14.3 (near the ARRDC3 gene, P = 1.67 × 10−9), and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene, P = 4.25 × 10−8). These associations were replicated in European-ancestry populations including 16,003 cases and 41,335 controls (P = 0.030, 0.004, and 0.010, respectively). Data from the ENCODE project suggest that variants rs4951011 and rs10474352 may be located in an enhancer region and transcription factor binding sites, respectively. This study provides additional insights into the genetics and biology of breast cancer. PMID:25038754

  17. Two girls with a de novo Xq rearrangement of paternal origin: t(X;9(q24;q12 or rea(Xdup q

    Directory of Open Access Journals (Sweden)

    Ana I. Vásquez-Velásquez

    2016-04-01

    Full Text Available Objective: We report on two rare Xq rearrangements, namely a t(X;9(q24;q12 found in a mildly-affected girl (Patient 1 and a rea(Xdup q concomitant with a rob(14;21mat in a Down syndrome girl (Patient 2. Case report: Both rearrangements were characterized by banding techniques [Giemsa (G, constitutive heterochromatin (C, and bromodeoxyuridine (BrdU pulse], fluorescence in situ hybridization (FISH assays, human androgen receptor (HUMAR assays, and microarray analyses. Patient 1 had a t(X;9(q24;q12dn. Patient 2 had a de novo rea(X(qter→q23 or q24::p11.2→qter concomitant with an unbalanced rob(14;21mat. X-Inactivation studies in metaphases and DNA revealed a fully skewed inactivation: the normal homolog was silenced in Patient 1 and the rea(X in Patient 2. Both rearranged X chromosomes were of paternal descent. Microarray analyses revealed no imbalances in Patient 1 whereas loss of Xp (∼52 Mb and duplication of Xq (∼44 Mb and 21q were confirmed in Patient 2. Conclusion: Our observations further document the cytogenetic heterogeneity and predominant paternal origin of certain de novo X-chromosome rearrangements.

  18. Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder

    Directory of Open Access Journals (Sweden)

    Grabe Hans

    2010-06-01

    Full Text Available Abstract Background Obsessive-compulsive disorder (OCD is a clinically and etiologically heterogeneous syndrome. The high frequency of obsessive-compulsive symptoms reported in subjects with the 22q11.2 deletion syndrome (DiGeorge/velocardiofacial syndrome or Prader-Willi syndrome (15q11-13 deletion of the paternally derived chromosome, suggests that gene dosage effects in these chromosomal regions could increase risk for OCD. Therefore, the aim of this study was to search for microrearrangements in these two regions in OCD patients. Methods We screened the 15q11-13 and 22q11.2 chromosomal regions for genomic imbalances in 236 patients with OCD using multiplex ligation-dependent probe amplification (MLPA. Results No deletions or duplications involving 15q11-13 or 22q11.2 were identified in our patients. Conclusions Our results suggest that deletions/duplications of chromosomes 15q11-13 and 22q11.2 are rare in OCD. Despite the negative findings in these two regions, the search for copy number variants in OCD using genome-wide array-based methods is a highly promising approach to identify genes of etiologic importance in the development of OCD.

  19. A 15q24 microduplication, reciprocal to the recently described 15q24 microdeletion, in a boy sharing clinical features with 15q24 microdeletion syndrome patients

    DEFF Research Database (Denmark)

    Lund, A.B. Kiholm; Hove, H.D.; Kirchhoff, M.

    2008-01-01

    A 15q24 microduplication, reciprocal to the minimal critical region for the recently described 15q24 microdeletion syndrome, was found in a 2-year-old boy by 244k Agilent oligoarray CGH analysis. The boy had global developmental delay and dysmorphic facial features, digital and genital abnormalit...

  20. The Escherichia coli COG1738 Member YhhQ Is Involved in 7-Cyanodeazaguanine (preQ0 Transport

    Directory of Open Access Journals (Sweden)

    Rémi Zallot

    2017-02-01

    Full Text Available Queuosine (Q is a complex modification of the wobble base in tRNAs with GUN anticodons. The full Q biosynthesis pathway has been elucidated in Escherichia coli. FolE, QueD, QueE and QueC are involved in the conversion of guanosine triphosphate (GTP to 7-cyano-7-deazaguanine (preQ0, an intermediate of increasing interest for its central role in tRNA and DNA modification and secondary metabolism. QueF then reduces preQ0 to 7-aminomethyl-7-deazaguanine (preQ1. PreQ1 is inserted into tRNAs by tRNA guanine(34 transglycosylase (TGT. The inserted base preQ1 is finally matured to Q by two additional steps involving QueA and QueG or QueH. Most Eubacteria harbor the full set of Q synthesis genes and are predicted to synthesize Q de novo. However, some bacteria only encode enzymes involved in the second half of the pathway downstream of preQ0 synthesis, including the signature enzyme TGT. Different patterns of distribution of the queF, tgt, queA and queG or queH genes are observed, suggesting preQ0, preQ1 or even the queuine base being salvaged in specific organisms. Such salvage pathways require the existence of specific 7-deazapurine transporters that have yet to be identified. The COG1738 family was identified as a candidate for a missing preQ0/preQ1 transporter in prokaryotes, by comparative genomics analyses. The existence of Q precursor salvage was confirmed for the first time in bacteria, in vivo, through an indirect assay. The involvement of the COG1738 in salvage of a Q precursor was experimentally validated in Escherichia coli, where it was shown that the COG1738 family member YhhQ is essential for preQ0 transport.

  1. Pisot q-coherent states quantization of the harmonic oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Gazeau, J.P., E-mail: gazeau@apc.univ-paris7.fr [Laboratoire APC, Univ. Paris Diderot, Sorbonne Paris Cite, 75205 Paris (France); Olmo, M.A. del, E-mail: olmo@fta.uva.es [Departamento de Fisica Teorica and IMEVA, Universidad de Valladolid, E-47005, Valladolid (Spain)

    2013-03-15

    We revisit the quantized version of the harmonic oscillator obtained through a q-dependent family of coherent states. For each q, 0<q<1, these normalized states form an overcomplete set that resolves the unity with respect to an explicit measure. We restrict our study to the case in which q{sup -1} is a quadratic unit Pisot number, since then the q-deformed integers form Fibonacci-like sequences of integers. We then examine the main characteristics of the corresponding quantum oscillator: localization in the configuration and in the phase spaces, angle operator, probability distributions and related statistical features, time evolution and semi-classical phase space trajectories. - Highlights: Black-Right-Pointing-Pointer Quantized version of the harmonic oscillator (HO) through a q-family of coherent states. Black-Right-Pointing-Pointer For q,0<q<1 these normalized states form an overcomplete set that resolves the unity with respect to an explicit measure. Black-Right-Pointing-Pointer q-Deformed numbers are Fibonacci-like integer sequences (1/q a quadratic unit Pisot number). Black-Right-Pointing-Pointer We examine the main physical characteristics of the corresponding quantum oscillator.

  2. Coenzyme Q 10: multiple benefits in one ingredient

    Directory of Open Access Journals (Sweden)

    Littarru Gian Paolo

    2011-03-01

    Full Text Available Coenzyme Q is a lipid molecule widely diffused in nature; in humans and other mammals it is present as coenzyme Q10. (CoQ10. The first recognized role of CoQ10 was in mitochondrial bioenergetics, where it plays a central role in the production of ATP. It is also present in other subcellular organelles, both in its oxidized and in its reduced state (ubiquinol-10. The reduced form of CoQ10 is endowed with powerful antioxidant activity: it acts as a chain-breaking antioxidant and is also capable of egenerating alpha-tocopherol, the active form of vitamin E. By these mechanisms CoQ10, together with vitamin E, protects lipoproteins from oxidation a process which bears considerable interest in preventing atherosclerosis. CoQ10 has also been found to support cardiovascular function and the latest findings indicate an active role in counteracting endothelial dysfunction, which is closely implicated in cardiovascular disease. CoQ10 also improves sperm motility, an effect which might be related both to its antioxidant and to its bioenergetic properties. Oxidative stress might be involved in neurodegenerative disease, and in migraine, two fields where the positive effects of CoQ10 have been documented. CoQ10 is synthesized by our body but is also present in food and can be taken as a nutritional supplement. The main source of industrially produced CoQ10 is yeast fermentation. The process results in CoQ10 which is identical to the naturally occurring molecule. Ubiquinol, the reduced form of CoQ10, has recently become available.

  3. q-Gamow states as continuous linear functionals on analytical test functions

    Energy Technology Data Exchange (ETDEWEB)

    Plastino, A.; Rocca, M.C., E-mail: mariocarlosrocca@gmail.com

    2016-04-15

    We define here q-Gamow states corresponding to Tsallis' q-statistics. We compute for them their norm, mean energy value and the q-analogue of the Breit–Wigner distribution (a q-Breit–Wigner).

  4. Tunable Q-Factor RF Cavity

    Energy Technology Data Exchange (ETDEWEB)

    Balcazar, Mario D. [Fermilab; Yonehara, Katsuya [Fermilab; Moretti, Alfred [Fermilab; Kazakevitch, Gregory [Fermilab

    2018-01-01

    Intense neutrino beam is a unique probe for researching beyond the standard model. Fermilab is the main institution to produce the most powerful and widespectrum neutrino beam. From that respective, a radiation robust beam diagnostic system is a critical element in order to maintain the quality of the neutrino beam. Within this context, a novel radiation-resistive beam profile monitor based on a gasfilled RF cavity is proposed. The goal of this measurement is to study a tunable Qfactor RF cavity to determine the accuracy of the RF signal as a function of the quality factor. Specifically, measurement error of the Q-factor in the RF calibration is investigated. Then, the RF system will be improved to minimize signal error.

  5. Data display with the Q system

    International Nuclear Information System (INIS)

    Oothoudt, M.A.

    1979-01-01

    The Q data-acquisition system for PDP-11 mini-computers at the Clinton P. Anderson Meson Physics Facility (LAMPF) provides experimenters with basic tools for on-line data display. Tasks are available to plot one- and two-parameter histograms on Tektronix 4000 series storage-tube terminals. The histograms to be displayed and the display format may be selected with simple keyboard commands. A task is also available to create and display live two-parameter scatter plots for any acquired or calculated quantities. Other tasks in the system manage the display data base, list display parameters and histogram contents on hardcopy devices, and save core histograms on disk or tape for off-line analysis. 8 figures

  6. Singularities of Type-Q ABS Equations

    Directory of Open Access Journals (Sweden)

    James Atkinson

    2011-07-01

    Full Text Available The type-Q equations lie on the top level of the hierarchy introduced by Adler, Bobenko and Suris (ABS in their classification of discrete counterparts of KdV-type integrable partial differential equations. We ask what singularities are possible in the solutions of these equations, and examine the relationship between the singularities and the principal integrability feature of multidimensional consistency. These questions are considered in the global setting and therefore extend previous considerations of singularities which have been local. What emerges are some simple geometric criteria that determine the allowed singularities, and the interesting discovery that generically the presence of singularities leads to a breakdown in the global consistency of such systems despite their local consistency property. This failure to be globally consistent is quantified by introducing a natural notion of monodromy for isolated singularities.

  7. Plasmonic enhancement of electroluminescence

    Science.gov (United States)

    Guzatov, D. V.; Gaponenko, S. V.; Demir, H. V.

    2018-01-01

    Here plasmonic effect specifically on electroluminescence (EL) is studied in terms of radiative and nonradiative decay rates for a dipole near a metal spherical nanoparticle (NP). Contribution from scattering is taken into account and is shown to play a decisive role in EL enhancement owing to pronounced size-dependent radiative decay enhancement and weak size effect on non-radiative counterpart. Unlike photoluminescence where local incident field factor mainly determines the enhancement possibility and level, EL enhancement is only possible by means of quantum yield rise, EL enhancement being feasible only for an intrinsic quantum yield Q0 red-orange range only. Independently of positive effect on quantum yield, metal nanoparticles embedded in an electroluminescent device will improve its efficiency at high currents owing to enhanced overall recombination rate which will diminish manifestation of Auger processes. The latter are believed to be responsible for the known undesirable efficiency droop in semiconductor commercial quantum well based LEDs at higher current. For the same reason plasmonics can diminish quantum dot photodegradation from Auger process induced non-radiative recombination and photoionization thus opening a way to avoid negative Auger effects in emerging colloidal semiconductor LEDs.

  8. High-Q/V Monolithic Diamond Microdisks Fabricated with Quasi-isotropic Etching.

    Science.gov (United States)

    Khanaliloo, Behzad; Mitchell, Matthew; Hryciw, Aaron C; Barclay, Paul E

    2015-08-12

    Optical microcavities enhance light-matter interactions and are essential for many experiments in solid state quantum optics, optomechanics, and nonlinear optics. Single crystal diamond microcavities are particularly sought after for applications involving diamond quantum emitters, such as nitrogen vacancy centers, and for experiments that benefit from diamond's excellent optical and mechanical properties. Light-matter coupling rates in experiments involving microcavities typically scale with Q/V, where Q and V are the microcavity quality-factor and mode-volume, respectively. Here we demonstrate that microdisk whispering gallery mode cavities with high Q/V can be fabricated directly from bulk single crystal diamond. By using a quasi-isotropic oxygen plasma to etch along diamond crystal planes and undercut passivated diamond structures, we create monolithic diamond microdisks. Fiber taper based measurements show that these devices support TE- and TM-like optical modes with Q > 1.1 × 10(5) and V < 11(λ/n) (3) at a wavelength of 1.5 μm.

  9. Effect of cooking and in vitro digestion on the stability of co-enzyme Q10 in processed meat products.

    Science.gov (United States)

    Tobin, Brian D; O'Sullivan, Maurice G; Hamill, Ruth; Kerry, Joseph P

    2014-05-01

    The use of CoQ10 fortification in the production of a functional food has been demonstrated in the past but primarily for dairy products. This study aimed to determine the bio-accessibility of CoQ10 in processed meat products, beef patties and pork breakfast sausages, fortified with CoQ10. Both the patties and sausages were fortified with a micellarized form of CoQ10 to enhance solubility to a concentration of 1mg/g of sample (NovaSolQ®). An assay was developed combining in vitro digestion and HPLC analysis to quantify the CoQ10 present in fortified products (100mg/g). The cooking retention level of CoQ10 in the products was found to be 74±1.42% for patties and 79.69±0.75% for sausages. The digestibility for both products ranged between 93% and 95%, sausages did have a higher digestibility level than patties but this was not found to be significant (P<0.01). Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Direct Comparison of 19F qNMR and 1H qNMR by Characterizing Atorvastatin Calcium Content

    Directory of Open Access Journals (Sweden)

    Yang Liu

    2016-01-01

    Full Text Available Quantitative nuclear magnetic resonance (qNMR is a powerful tool in measuring drug content because of its high speed, sensitivity, and precision. Most of the reports were based on proton qNMR (1H qNMR and only a few fluorine qNMR (19F qNMR were reported. No research has been conducted to directly compare the advantage and disadvantage between these two methods. In the present study, both 19F and 1H qNMR were performed to characterize the content of atorvastatin calcium with the same internal standard. Linearity, precision, and results from two methods were compared. Results showed that 19F qNMR has similar precision and sensitivity to 1H qNMR. Both methods generate similar results compared to mass balance method. Major advantage from 19F qNMR is that the analyte signal is with less or no interference from impurities. 19F qNMR is an excellent approach to quantify fluorine-containing analytes.

  11. Metering instrument of quality factor Q of gravitational wave antenna

    International Nuclear Information System (INIS)

    Jia-yan, C.; Tong-ren, G.

    1982-01-01

    The quality factor, Q, of gravitational wave antenna depends on the material property as well as external conditions, such as temperature, residual pressure in vacuum tank, support type, additional loss from transducer on antenna, etc. In order to find out the relationship between the antenna Q and external conditions automatical operating in succession is required. The authors have designed and made a metering instrument for quality factor Q. The metering instrument of Q can measure Q of the metal cylinder and other bar of higher Q. It can give data of the measurement at regular intervals as desired. It can measure accurately the longitudinal fundamental mode frequency of the cylinder with a digital frequency meter record oscillating signal from metering instrument. Because the metering instrument excites free-vibration of the cylinder with free-running type and keep up the stationary amplitude for a long time. (Auth.)

  12. Applying incomplete statistics to nonextensive systems with different q indices

    International Nuclear Information System (INIS)

    Nivanen, L.; Pezeril, M.; Wang, Q.A.; Mehaute, A. Le

    2005-01-01

    The nonextensive statistics based on the q-entropy Sq=--bar i=1v(pi-piq)1-q has been so far applied to systems in which the q value is uniformly distributed. For the systems containing different q's, the applicability of the theory is still a matter of investigation. The difficulty is that the class of systems to which the theory can be applied is actually limited by the usual nonadditivity rule of entropy which is no more valid when the systems contain non uniform distribution of q values. In this paper, within the framework of the so called incomplete information theory, we propose a more general nonadditivity rule of entropy prescribed by the zeroth law of thermodynamics. This new nonadditivity generalizes in a simple way the usual one and can be proved to lead uniquely to the q-entropy

  13. Molecular structure and spectral properties of ethyl 3-quinolinecarboxylate (E3Q) and [Ag(E3Q)2(TCA)] complex (TCA = Trichloroacetate)

    Science.gov (United States)

    Soliman, Saied M.; Kassem, Taher S.; Badr, Ahmed M. A.; Abou Youssef, Morsy A.; Assem, Rania

    2014-09-01

    A new [Ag(E3Q)2(TCA)] complex; (E3Q = Ethyl 3-quinolinecarboxylate and TCA = Trichloroacetate) has been synthesized and characterized using elemental analysis, FTIR, NMR and mass spectroscopy. The molecular geometry and spectroscopic properties of the complex as well as the free ligand have been calculated using the hybrid B3LYP method. The calculations predicted a distorted tetrahedral arrangement around Ag(I) ion. The vibrational spectra of the studied compounds have been assigned using potential energy distribution (PED). TD-DFT method was used to predict the electronic absorption spectra. The most intense absorption band showed a bathochromic shift and lowering of intensity in case of the complex (233.7 nm, f = 0.5604) compared to E3Q (λmax = 228.0 nm, f = 0.9072). The calculated 1H NMR chemical shifts using GIAO method showed good correlations with the experimental data. The computed dipole moment, polarizability and HOMO-LUMO energy gap were used to predict the nonlinear optical (NLO) properties. It is found that Ag(I) enhances the NLO activity. The natural bond orbital (NBO) analyses were used to elucidate the intramolecular charge transfer interactions causing stabilization for the investigated systems.

  14. Image processing with massively parallel computer Quadrics Q1

    International Nuclear Information System (INIS)

    Della Rocca, A.B.; La Porta, L.; Ferriani, S.

    1995-05-01

    Aimed to evaluate the image processing capabilities of the massively parallel computer Quadrics Q1, a convolution algorithm that has been implemented is described in this report. At first the discrete convolution mathematical definition is recalled together with the main Q1 h/w and s/w features. Then the different codification forms of the algorythm are described and the Q1 performances are compared with those obtained by different computers. Finally, the conclusions report on main results and suggestions

  15. Fisher information, Borges operators, and q-calculus

    Science.gov (United States)

    Pennini, F.; Plastino, A.; Ferri, G. L.

    2008-10-01

    We discuss applying the increasingly popular q-calculus, or deformed calculus, so as to suitably generalize Fisher’s information measure and the Cramer-Rao inequality. A q-deformation can be attained in multiple ways, and we show that most of them do not constitute legitimate procedures. Within such a context, the only completely acceptable q-deformation is that ensuing from using the so-called Borges derivative [E.P. Borges, Physica A 340 (2004) 95].

  16. Systematics of q6 systems in a simple chromomagnetic model

    International Nuclear Information System (INIS)

    Silvestre-Brac, B.; Leandri, J.

    1992-01-01

    In the framework of a pure chromomagnetic Hamiltonian we study all the q 6 systems allowed by the Pauli principle. In a first step, where we consider an exact SU(3) F symmetry, the wave functions are analyzed by group-theoretical techniques. The breaking of the flavor symmetry is performed exactly by introducing a parameter δ. The emphasis is put on the corresponding energies relative to the q 3 +q 3 thresholds

  17. Anti-C1q antibodies in systemic lupus erythematosus

    DEFF Research Database (Denmark)

    Orbai, A-M; Truedsson, L; Sturfelt, G

    2015-01-01

    OBJECTIVE: Anti-C1q has been associated with systemic lupus erythematosus (SLE) and lupus nephritis in previous studies. We studied anti-C1q specificity for SLE (vs rheumatic disease controls) and the association with SLE manifestations in an international multicenter study. METHODS: Information...... in combination with anti-dsDNA and low complement was the strongest serological association with renal involvement. These data support the usefulness of anti-C1q in SLE, especially in lupus nephritis....

  18. The Hankel Transform of q-Noncentral Bell Numbers

    Directory of Open Access Journals (Sweden)

    Cristina B. Corcino

    2015-01-01

    Full Text Available We define two forms of q-analogue of noncentral Stirling numbers of the second kind and obtain some properties parallel to those of noncentral Stirling numbers. Certain combinatorial interpretation is given for the second form of the q-analogue in the context of 0-1 tableaux which, consequently, yields certain additive identity and some convolution-type formulas. Finally, a q-analogue of noncentral Bell numbers is defined and its Hankel transform is established.

  19. Search for possible 6-q states via inclusive reactions

    International Nuclear Information System (INIS)

    Bhatia, T.S.

    1984-01-01

    A satisfactory understanding of the 6-q system is necessary for a complete understanding of the short-range part of the NN interaction. Bag models and quark potential models predict 6-q states in the 2 to 3 GeV mass range. NNπ and NNππ are examples of 6-q states involving the same quark flavors as the NN system, search for which could be undertaken through inclusive spin-dependent measurements

  20. On the q-Weibull distribution for reliability applications: An adaptive hybrid artificial bee colony algorithm for parameter estimation

    International Nuclear Information System (INIS)

    Xu, Meng; Droguett, Enrique López; Lins, Isis Didier; Chagas Moura, Márcio das

    2017-01-01

    The q-Weibull model is based on the Tsallis non-extensive entropy and is able to model various behaviors of the hazard rate function, including bathtub curves, by using a single set of parameters. Despite its flexibility, the q-Weibull has not been widely used in reliability applications partly because of the complicated parameters estimation. In this work, the parameters of the q-Weibull are estimated by the maximum likelihood (ML) method. Due to the intricate system of nonlinear equations, derivative-based optimization methods may fail to converge. Thus, the heuristic optimization method of artificial bee colony (ABC) is used instead. To deal with the slow convergence of ABC, it is proposed an adaptive hybrid ABC (AHABC) algorithm that dynamically combines Nelder-Mead simplex search method with ABC for the ML estimation of the q-Weibull parameters. Interval estimates for the q-Weibull parameters, including confidence intervals based on the ML asymptotic theory and on bootstrap methods, are also developed. The AHABC is validated via numerical experiments involving the q-Weibull ML for reliability applications and results show that it produces faster and more accurate convergence when compared to ABC and similar approaches. The estimation procedure is applied to real reliability failure data characterized by a bathtub-shaped hazard rate. - Highlights: • Development of an Adaptive Hybrid ABC (AHABC) algorithm for q-Weibull distribution. • AHABC combines local Nelder-Mead simplex method with ABC to enhance local search. • AHABC efficiently finds the optimal solution for the q-Weibull ML problem. • AHABC outperforms ABC and self-adaptive hybrid ABC in accuracy and convergence speed. • Useful model for reliability data with non-monotonic hazard rate.

  1. Coenzyme Q10 Attenuates High Glucose-Induced Endothelial Progenitor Cell Dysfunction through AMP-Activated Protein Kinase Pathways

    Directory of Open Access Journals (Sweden)

    Hsiao-Ya Tsai

    2016-01-01

    Full Text Available Coenzyme Q10 (CoQ10, an antiapoptosis enzyme, is stored in the mitochondria of cells. We investigated whether CoQ10 can attenuate high glucose-induced endothelial progenitor cell (EPC apoptosis and clarified its mechanism. EPCs were incubated with normal glucose (5 mM or high glucose (25 mM enviroment for 3 days, followed by treatment with CoQ10 (10 μM for 24 hr. Cell proliferation, nitric oxide (NO production, and JC-1 assay were examined. The specific signal pathways of AMP-activated protein kinase (AMPK, eNOS/Akt, and heme oxygenase-1 (HO-1 were also assessed. High glucose reduced EPC functional activities, including proliferation and migration. Additionally, Akt/eNOS activity and NO production were downregulated in high glucose-stimulated EPCs. Administration of CoQ10 ameliorated high glucose-induced EPC apoptosis, including downregulation of caspase 3, upregulation of Bcl-2, and increase in mitochondrial membrane potential. Furthermore, treatment with CoQ10 reduced reactive oxygen species, enhanced eNOS/Akt activity, and increased HO-1 expression in high glucose-treated EPCs. These effects were negated by administration of AMPK inhibitor. Transplantation of CoQ10-treated EPCs under high glucose conditions into ischemic hindlimbs improved blood flow recovery. CoQ10 reduced high glucose-induced EPC apoptosis and dysfunction through upregulation of eNOS, HO-1 through the AMPK pathway. Our findings provide a potential treatment strategy targeting dysfunctional EPC in diabetic patients.

  2. Coenzyme Q10 Attenuates High Glucose-Induced Endothelial Progenitor Cell Dysfunction through AMP-Activated Protein Kinase Pathways

    Science.gov (United States)

    Tsai, Hsiao-Ya; Lin, Chih-Pei; Huang, Po-Hsun; Li, Szu-Yuan; Chen, Jia-Shiong; Lin, Feng-Yen; Chen, Jaw-Wen; Lin, Shing-Jong

    2016-01-01

    Coenzyme Q10 (CoQ10), an antiapoptosis enzyme, is stored in the mitochondria of cells. We investigated whether CoQ10 can attenuate high glucose-induced endothelial progenitor cell (EPC) apoptosis and clarified its mechanism. EPCs were incubated with normal glucose (5 mM) or high glucose (25 mM) enviroment for 3 days, followed by treatment with CoQ10 (10 μM) for 24 hr. Cell proliferation, nitric oxide (NO) production, and JC-1 assay were examined. The specific signal pathways of AMP-activated protein kinase (AMPK), eNOS/Akt, and heme oxygenase-1 (HO-1) were also assessed. High glucose reduced EPC functional activities, including proliferation and migration. Additionally, Akt/eNOS activity and NO production were downregulated in high glucose-stimulated EPCs. Administration of CoQ10 ameliorated high glucose-induced EPC apoptosis, including downregulation of caspase 3, upregulation of Bcl-2, and increase in mitochondrial membrane potential. Furthermore, treatment with CoQ10 reduced reactive oxygen species, enhanced eNOS/Akt activity, and increased HO-1 expression in high glucose-treated EPCs. These effects were negated by administration of AMPK inhibitor. Transplantation of CoQ10-treated EPCs under high glucose conditions into ischemic hindlimbs improved blood flow recovery. CoQ10 reduced high glucose-induced EPC apoptosis and dysfunction through upregulation of eNOS, HO-1 through the AMPK pathway. Our findings provide a potential treatment strategy targeting dysfunctional EPC in diabetic patients. PMID:26682233

  3. On q-extension of Laurent expansion with applications

    Directory of Open Access Journals (Sweden)

    Ahmed Salem

    2014-01-01

    Full Text Available In this article, Cauchy’s integral formula for nth q-derivative of analytic functions is established and used to introduce a new proof to q-Taylor series by means of using the residue calculus in the complex analysis. Some theorems related to this formula are presented. A q-extension of a Laurent expansion is derived and proved by means of using Cauchy’s integral formula for a function, which is analytic on a ring-shaped region bounded by two concentric circles. Three illustrative examples are presented to be as applications for a q-Laurent expansion.

  4. Q Fever: An Old but Still a Poorly Understood Disease

    Directory of Open Access Journals (Sweden)

    Hamidreza Honarmand

    2012-01-01

    Full Text Available Q fever is a bacterial infection affecting mainly the lungs, liver, and heart. It is found around the world and is caused by the bacteria Coxiella burnetii. The bacteria affects sheep, goats, cattle, dogs, cats, birds, rodents, and ticks. Infected animals shed this bacteria in birth products, feces, milk, and urine. Humans usually get Q fever by breathing in contaminated droplets released by infected animals and drinking raw milk. People at highest risk for this infection are farmers, laboratory workers, sheep and dairy workers, and veterinarians. Chronic Q fever develops in people who have been infected for more than 6 months. It usually takes about 20 days after exposure to the bacteria for symptoms to occur. Most cases are mild, yet some severe cases have been reported. Symptoms of acute Q fever may include: chest pain with breathing, cough, fever, headache, jaundice, muscle pains, and shortness of breath. Symptoms of chronic Q fever may include chills, fatigue, night sweats, prolonged fever, and shortness of breath. Q fever is diagnosed with a blood antibody test. The main treatment for the disease is with antibiotics. For acute Q fever, doxycycline is recommended. For chronic Q fever, a combination of doxycycline and hydroxychloroquine is often used long term. Complications are cirrhosis, hepatitis, encephalitis, endocarditis, pericarditis, myocarditis, interstitial pulmonary fibrosis, meningitis, and pneumonia. People at risk should always: carefully dispose of animal products that may be infected, disinfect any contaminated areas, and thoroughly wash their hands. Pasteurizing milk can also help prevent Q fever.

  5. The q-Statistics and QCD Thermodynamics at LHC

    CERN Document Server

    Bhattacharyya, Trambak; Sahoo, Pragati; Garg, Prakhar; Pareek, Pooja; Sahoo, Raghunath; Cleymans, Jean

    2016-01-01

    We perform a Taylor series expansion of Tsallis distribution by assuming the Tsallis parameter $q$ close to 1. The $q$ value shows the deviation of a system from a thermalised Boltzmann distribution. By taking up to first order in $(q-1)$, we derive an analytical result for Tsallis distribution including radial flow. Further, in the present work, we also study the speed of sound ($c_s$) as a function of temperature using the non-extensive Tsallis statistics for different $q$ values and for different mass cut-offs.

  6. Direct interaction between CD91 and C1q

    DEFF Research Database (Denmark)

    Duus, Karen; Hansen, Erik W; Tacnet, Pascale

    2010-01-01

    . C1q binding to monocytes was shown to be correlated with CD91 expression and could be inhibited by the CD91 chaperone, receptor-associated protein. We also report data showing a direct interaction between CD91 and C1q. The interaction was investigated using various protein interaction assays....... A direct interaction between purified C1q and CD91 was observed both by ELISA and a surface plasmon resonance assay, with either C1q or CD91 immobilized. The interaction showed characteristics of specificity because it was time-dependent, saturable and could be inhibited by known ligands of both CD91 and C...

  7. Q-operators for the open Heisenberg spin chain

    Directory of Open Access Journals (Sweden)

    Rouven Frassek

    2015-12-01

    Full Text Available We construct Q-operators for the open spin-12 XXX Heisenberg spin chain with diagonal boundary matrices. The Q-operators are defined as traces over an infinite-dimensional auxiliary space involving novel types of reflection operators derived from the boundary Yang–Baxter equation. We argue that the Q-operators defined in this way are polynomials in the spectral parameter and show that they commute with transfer matrix. Finally, we prove that the Q-operators satisfy Baxter's TQ-equation and derive the explicit form of their eigenvalues in terms of the Bethe roots.

  8. Coenzyme Q10 protects hair cells against aminoglycoside.

    Directory of Open Access Journals (Sweden)

    Kazuma Sugahara

    Full Text Available It is well known that the production of free radicals is associated with sensory cell death induced by an aminoglycoside. Many researchers have reported that antioxidant reagents protect sensory cells in the inner ear, and coenzyme Q10 (CoQ10 is an antioxidant that is consumed as a health food in many countries. The purpose of this study was to investigate the role of CoQ10 in mammalian vestibular hair cell death induced by aminoglycoside. Cultured utricles of CBA/CaN mice were divided into three groups (control group, neomycin group, and neomycin + CoQ10 group. In the neomycin group, utricles were cultured with neomycin (1 mM to induce hair cell death. In the neomycin + CoQ10 group, utricles were cultured with neomycin and water-soluble CoQ10 (30-0.3 µM. Twenty-four hours after exposure to neomycin, the cultured tissues were fixed, and vestibular hair cells were labeled using an anti-calmodulin antibody. Significantly more hair cells survived in the neomycin + CoQ10 group than in the neomycin group. These data indicate that CoQ10 protects sensory hair cells against neomycin-induced death in the mammalian vestibular epithelium; therefore, CoQ10 may be useful as a protective drug in the inner ear.

  9. Q-boson interferometry and generalized Wigner function

    International Nuclear Information System (INIS)

    Zhang, Q.H.; Padula, Sandra S.

    2004-01-01

    Bose-Einstein correlations of two identically charged Q bosons are derived considering these particles to be confined in finite volumes. Boundary effects on single Q-boson spectrum are also studied. We illustrate the effects on the spectrum and on the two-Q-boson correlation function by means of two toy models. We also derive a generalized expression for the Wigner function depending on the deformation parameter Q, which is reduced to its original functional form in the limit of Q→1

  10. DIMENSI METRIK GRAPH LOBSTER Ln (q;r

    Directory of Open Access Journals (Sweden)

    PANDE GDE DONY GUMILAR

    2013-05-01

    Full Text Available The metric dimension of connected graph G is the cardinality of minimum resolving set in graph G. In this research, we study how to find the metric dimension of lobster graph Ln (q;r. Lobster graph Ln (q;r is a regular lobster graph with vertices backbone on the main path, every backbone vertex is connected to q hand vertices and every hand vertex is connected to r finger vertices, with n, q, r element of N. We obtain the metric dimension of lobster graph L2 (1;1 is 1, the metric dimension of lobster graph L2 (1;1 for n > 2 is 2.

  11. A q-deformed logistic map and its implications

    International Nuclear Information System (INIS)

    Banerjee, Subhashish; Parthasarathy, R

    2011-01-01

    A new q-deformed logistic map is proposed and it is found to have concavity in parts of the x-space. Its one-cycle and two-cycle non-trivial fixed points are obtained which are found to be qualitatively and quantitatively different from those of the usual logistic map. The stability of the proposed q-logistic map is studied using the Lyapunov exponent, and with a change in the value of the deformation parameter q, one is able to go from the chaotic to regular dynamical regime. The implications of this q-logistic map on Parrondo's paradox are examined.

  12. Numerical study of Q-ball formation in gravity mediation

    International Nuclear Information System (INIS)

    Hiramatsu, Takashi; Kawasaki, Masahiro; Takahashi, Fuminobu

    2010-01-01

    We study Q-ball formation in the expanding universe on 1D, 2D and 3D lattice simulations. We obtain detailed Q-ball charge distributions, and find that the distribution is peaked at Q 3D peak ≅ 1.9 × 10 −2 (|Φ in |/m) 2 , which is greater than the existing result by about 60%. Based on the numerical simulations, we discuss how the Q-ball formation proceeds. Also we make a comment on possible deviation of the charge distributions from what was conjectured in the past

  13. Toward the correspondence between Q-clouds and sphalerons

    Energy Technology Data Exchange (ETDEWEB)

    Nugaev, E., E-mail: emin@ms2.inr.ac.ru [Institute for Nuclear Research of the Russian Academy of Sciences, 60th October Anniversary prospect 7a, 117312, Moscow (Russian Federation); Shkerin, A., E-mail: shkerin@inr.ru [Institute for Nuclear Research of the Russian Academy of Sciences, 60th October Anniversary prospect 7a, 117312, Moscow (Russian Federation); École Polytechnique Fédérale de Lausanne, CH-1015, Lausanne (Switzerland)

    2015-07-30

    Non-linear classical equations of motion may admit degenerate solutions at fixed charges. Whereas the solutions with lower energies are classically stable, those with larger energies are unstable and are referred to as Q-clouds. We consider a theory in which a homogeneous charged condensate is classically stable and argue that Q-clouds correspond to sphalerons between the stable Q-balls and the condensate. For a model with an analytical solution, we present the Arrhenius formula for the quantum production of Q-balls from a condensate at high temperatures.

  14. Development and Application of POSAFE-Q PLC Platform

    International Nuclear Information System (INIS)

    Lee, MyeongKyun; Song, SeungWhan; Yun, DongHwa

    2012-01-01

    The Safety-grade Programmable Logic Controller (PLC) Platform named POSAFE-Q was developed so that it meets the requirements of the Safety Class 1E, Quality Class 1, and Seismic Category I. Development process of the POSAFE-Q software developed in accordance with software life cycles. The POSAFE-Q meets safety and suitability for design are based on digital I and C laws, guidelines and technical standards. The POSAFE-Q PLC obtained approval for Topical Report from the Nuclear Safety and Security Commission in Korea. (author)

  15. New infiniti Q45. Shingata Infiniti Q45'' ni tsuite

    Energy Technology Data Exchange (ETDEWEB)

    Oka, T.; Ochiai, A.; Kato, Y. (Nissan Motor Co. Ltd., Tokyo (Japan))

    1989-12-25

    This report introduces the concept for development and the outline of the Infiniti Q45, a new luxury sedan Nissan has developed, and special activities Nissan makes to produce luxury cars. This sedan was developed with the concept of producing a large-sized luxury car of evidently Japanese make to earn the world appraisal; a touring saloon whose style is original and unique based on the sensitivity of Japanese and yet which has the performance of a sports car. Every part of the Infiniti Q45, from the V8 engine and the 4.5 L DOHC 32 valve engine to the hydraulic active suspension, the first to be loaded on a mass production car, features Nissan's innovative and leading-edge technology. Moreover, to provide maximum customer satisfaction in every scene from the purchase of a car to services, various constructive programs have been adopted with the key word, Total Ownership Experience. 8 figs., 2 tabs.

  16. De novo 12q22.q23.3 duplication associated with temporal lobe epilepsy.

    Science.gov (United States)

    Vari, Maria Stella; Traverso, Monica; Bellini, Tommaso; Madia, Francesca; Pinto, Francesca; Minetti, Carlo; Striano, Pasquale; Zara, Federico

    2017-08-01

    Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy and may be associated with acquired central nervous system lesions or could be genetic. Various susceptibility genes and environmental factors are believed to be involved in the aetiology of TLE, which is considered to be a heterogeneous, polygenic, and complex disorder. Rare point mutations in LGI1, DEPDC5, and RELN as well as some copy number variations (CNVs) have been reported in families with TLE patients. We perform a genetic analysis by Array-CGH in a patient with dysmorphic features and temporal lobe epilepsy. We report a de novo duplication of the long arm of chromosome 12. We confirm that 12q22-q23.3 is a candidate locus for familial temporal lobe epilepsy with febrile seizures and highlight the role of chromosomal rearrangements in patients with epilepsy and intellectual disability. Copyright © 2017 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.

  17. Active filter for INDUS-2 Q4 and Q5 power supplies

    International Nuclear Information System (INIS)

    Singh, Y.P.; Thakurta, A.C.; Kotaiah, S.

    2003-01-01

    Q4 and Q5 power supplies are SCR based power supplies wherein the rectified voltage is fed to a passive filter to reduce the ripple voltage. The output of the passive filter still contains some ripple particularly on the low frequency side. Attenuation of this ripple with passive filter necessitates increase in size of L and C and leads to sluggishness of the system. The design and the test results of an active filter module have been discussed wherein the low frequency attenuation can be very effectively taken care of by, allowing this to be absorbed in a coupling transformer put after the passive filter. Considerable size reduction has been achieved by using switching techniques. Low frequency attenuation has been made quite a simple task. This filter also helps in handling transients from input. (author)

  18. HiQ - A high-Q diffractometer for PDF measurements

    International Nuclear Information System (INIS)

    Brunelli, M.; Fischer, H.E.; Gaehler, R.; Chatterji, T.

    2011-01-01

    The local structure of many important functional materials is often different from the average structure, as revealed by diffraction, due to, e.g. doping, mixed site occupancy, or formation of time-dependent local distortions. To get information on both the average and the local structures one needs to perform a joint Rietveld and PDF (Pair Distribution Function) analysis of the total scattering, for which we need data to Q = 30 - 35 Angstroms with Δd/d ∼ 3*10 -3 . Here, we describe how the hot-source diffractometer D4 can be adapted to achieve this capability, and outline one possible design of a dedicated high-Q diffractometer at the ILL (Laue Langevin Institute), using the vacant inclined hot-neutron beam IH2. (authors)

  19. Twin photon pairs in a high-Q silicon microresonator

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, Steven; Lu, Xiyuan [Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627 (United States); Jiang, Wei C. [Institute of Optics, University of Rochester, Rochester, New York 14627 (United States); Lin, Qiang, E-mail: qiang.lin@rochester.edu [Institute of Optics, University of Rochester, Rochester, New York 14627 (United States); Department of Electrical and Computer Engineering, University of Rochester, Rochester, New York 14627 (United States)

    2015-07-27

    We report the generation of high-purity twin photon pairs through cavity-enhanced non-degenerate four-wave mixing (FWM) in a high-Q silicon microdisk resonator. Twin photon pairs are created within the same cavity mode and are consequently expected to be identical in all degrees of freedom. The device is able to produce twin photons at telecommunication wavelengths with a pair generation rate as large as (3.96 ± 0.03) × 10{sup 5} pairs/s, within a narrow bandwidth of 0.72 GHz. A coincidence-to-accidental ratio of 660 ± 62 was measured, the highest value reported to date for twin photon pairs, at a pair generation rate of (2.47 ± 0.04) × 10{sup 4} pairs/s. Through careful engineering of the dispersion matching window, we have reduced the ratio of photons resulting from degenerate FWM to non-degenerate FWM to less than 0.15.

  20. LAMMPS strong scaling performance optimization on Blue Gene/Q

    Energy Technology Data Exchange (ETDEWEB)

    Coffman, Paul; Jiang, Wei; Romero, Nichols A.

    2014-11-12

    LAMMPS "Large-scale Atomic/Molecular Massively Parallel Simulator" is an open-source molecular dynamics package from Sandia National Laboratories. Significant performance improvements in strong-scaling and time-to-solution for this application on IBM's Blue Gene/Q have been achieved through computational optimizations of the OpenMP versions of the short-range Lennard-Jones term of the CHARMM force field and the long-range Coulombic interaction implemented with the PPPM (particle-particle-particle mesh) algorithm, enhanced by runtime parameter settings controlling thread utilization. Additionally, MPI communication performance improvements were made to the PPPM calculation by re-engineering the parallel 3D FFT to use MPICH collectives instead of point-to-point. Performance testing was done using an 8.4-million atom simulation scaling up to 16 racks on the Mira system at Argonne Leadership Computing Facility (ALCF). Speedups resulting from this effort were in some cases over 2x.

  1. Responses of evergreen and deciduous Quercus species to enhanced ozone levels

    International Nuclear Information System (INIS)

    Calatayud, Vicent; Cervero, Julia; Calvo, Esperanza; Garcia-Breijo, Francisco-Jose; Reig-Arminana, Jose; Sanz, Maria Jose

    2011-01-01

    Plants of one evergreen oak (Quercus ilex) and three deciduous oaks (Q. faginea, with small leaves; Q. pyrenaica and Q. robur, with large leaves) were exposed both to filtered air and to enhanced ozone levels in Open-Top Chambers. Q. faginea and Q. pyrenaica were studied for the first time. Based on visible injury, gas exchange, chlorophyll content and biomass responses, Q. pyrenaica was the most sensitive species, and Q. ilex was the most tolerant, followed by Q. faginea. Functional leaf traits of the species were related to differences in sensitivity, while accumulated ozone flux via stomata (POD 1.6 ) partly contributed to the observed differences. For risk assessment of Mediterranean vegetation, the diversity of responses detected in this study should be taken into account, applying appropriate critical levels. - Ozone tolerance overlapped with leaf traits in four Quercus species.

  2. Responses of evergreen and deciduous Quercus species to enhanced ozone levels

    Energy Technology Data Exchange (ETDEWEB)

    Calatayud, Vicent, E-mail: calatayud_viclor@gva.e [Instituto Universitario CEAM-UMH, Charles R. Darwin 14, Parc Tecnologic, 46980 Paterna, Valencia (Spain); Cervero, Julia; Calvo, Esperanza [Instituto Universitario CEAM-UMH, Charles R. Darwin 14, Parc Tecnologic, 46980 Paterna, Valencia (Spain); Garcia-Breijo, Francisco-Jose [Laboratorio de Anatomia e Histologia Vegetal ' Julio Iranzo' , Jardin Botanico, Universitat de Valencia, c/Quart 80, 46008 Valencia (Spain); Departamento de Ecosistemas Agroforestales, Escuela Tecnica Superior del Medio Rural y Enologia, Universidad Politecnica de Valencia, Avda. Blasco Ibanez 21, 46010 Valencia (Spain); Reig-Arminana, Jose [Departamento de Ecosistemas Agroforestales, Escuela Tecnica Superior del Medio Rural y Enologia, Universidad Politecnica de Valencia, Avda. Blasco Ibanez 21, 46010 Valencia (Spain); Sanz, Maria Jose [Instituto Universitario CEAM-UMH, Charles R. Darwin 14, Parc Tecnologic, 46980 Paterna, Valencia (Spain)

    2011-01-15

    Plants of one evergreen oak (Quercus ilex) and three deciduous oaks (Q. faginea, with small leaves; Q. pyrenaica and Q. robur, with large leaves) were exposed both to filtered air and to enhanced ozone levels in Open-Top Chambers. Q. faginea and Q. pyrenaica were studied for the first time. Based on visible injury, gas exchange, chlorophyll content and biomass responses, Q. pyrenaica was the most sensitive species, and Q. ilex was the most tolerant, followed by Q. faginea. Functional leaf traits of the species were related to differences in sensitivity, while accumulated ozone flux via stomata (POD{sub 1.6}) partly contributed to the observed differences. For risk assessment of Mediterranean vegetation, the diversity of responses detected in this study should be taken into account, applying appropriate critical levels. - Ozone tolerance overlapped with leaf traits in four Quercus species.

  3. Trisomy 1q42-qter associated with monosomy 6q27-qter: a case report.

    Science.gov (United States)

    Tartaglia, Edoardo; Mastrantonio, Pasquale; Costa, Davide; Giugliano, Brunella; Porcellini, Antonio; Costagliola, Ciro

    2011-01-01

    Partial trisomy 1q42-qter is a rare chromosomal aberration. Most cases arise from de novo unbalanced translocations or from unbalanced inheritance of parental balanced rearrangements. Descriptive case report. A 4-year-old boy had shown an increased neck translucency at the fetal ultrasound examination performed at the 11th week of gestation. Amniocentesis, performed at the 18th week of gestation, did not demonstrate any genetic abnormality. A second fetal ultrasound examination, carried out at the 35th week of gestation, showed congenital clubfeet and hydrocephalus. At birth, clinical examination revealed congenital bilateral ventriculomegaly, bilateral congenital equinovarus clubfeet, low-set ears, plagiocephaly, micrognathia, hypertelorism, prominent forehead, broad nasal bridge, hypertonic syndrome, and inguinal hernia. Ophthalmologic consultation showed the presence of optic pit in his left eye. Genetic counseling was performed. Chromosome analysis demonstrated a partial trisomy 1q42.2-qter associated with a partial monosomy 6q27-qter. Moreover, deletions of the distal region on the long arm of chromosome 6 are frequently associated with both ocular abnormalities and several solid tumor types. Moderate mental and psychomotor retardation has occurred. This case emphasizes the importance of scheduling a screening test for eye diseases and tumor in these patients.

  4. Language Impairment Resulting from a de novo Deletion of 7q32.1q33.

    Science.gov (United States)

    Jiménez-Romero, María S; Barcos-Martínez, Montserrat; Espejo-Portero, Isabel; Benítez-Burraco, Antonio

    2016-10-01

    We report on a girl who presents with hearing loss, behavioral disturbances (according to the Inventory for Client and Agency Planning) as well as motor and cognitive delay (according to Battelle Developmental Inventories) which have a significant impact on her speech and language abilities [according to the Peabody Picture Vocabulary Test (ed 3), and the Prueba de Lenguaje Oral de Navarra-Revisada (Navarra Oral Language Test, Revised)]. Five copy number variations (CNVs) were identified in the child: arr[hg18] 7q32.1q33(127109685-132492196)×1, 8p23.1(7156900-7359099) ×1, 15q13.1(26215673-26884937)×1, Xp22.33(17245- 102434)×3, and Xp22.33(964441-965024)×3. The pathogenicity of similar CNVs is mostly reported as unknown. The largest deletion is found in a hot spot for cognitive disease and language impairment and contains several genes involved in brain development and function, many of which have been related to developmental disorders encompassing language deficits (dyslexia, speech-sound disorder, and autism). Some of these genes interact with FOXP2 . The proband's phenotype may result from a reduced expression of some of these genes.

  5. Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis.

    Science.gov (United States)

    Wittmann, Stefanie; Zirn, Birgit; Alkassar, Muhannad; Ambros, Peter; Graf, Norbert; Gessler, Manfred

    2007-02-01

    Allele loss of chromosome arms 11q and 16q in Wilms tumors has been associated with different clinical parameters in prior studies. To substantiate these findings in a large collection of tumors treated according to the GPOH/SIOP protocol and to narrow down critical regions, we performed loss of heterozygosity (LOH) analyses of chromosome arms 11q and 16q on 225 Wilms tumors. On chromosome arm 11q an overall rate of allele loss of 19.6% (44 of 225 tumors) was found using eleven markers that were almost evenly distributed along the long arm. Chromosome arm 16q was analyzed with six markers selected from gene-rich regions that identified an LOH rate of 18.4% (41/223). Evaluation of LOH with respect to clinical data revealed significant associations of LOH 11q with histology: LOH 11q was 3-4 times more frequent in mixed type and diffuse anaplastic tumors. In contrast, epithelial as well as stromal type tumors never exhibited allele loss on 11q. Furthermore, a significant correlation with tumor recurrence and death was detected, but only for tumors that lost the entire long arm of chromosome 11. Similarly, LOH 16q was correlated with higher risks of later relapse, especially in tumors with complete loss of the long arm. Hence, analyses of LOH on 11q and 16q appear to be helpful to identify tumors with a higher risk of relapse and adverse outcome, which need adjusted therapeutic approaches. Copyright 2006 Wiley-Liss, Inc.

  6. Constitutional 11q14-q22 chromosome deletion syndrome in a child with neuroblastoma MYCN single copy.

    Science.gov (United States)

    Passariello, Annalisa; De Brasi, Daniele; Defferrari, Raffaella; Genesio, Rita; Tufano, Maria; Mazzocco, Katia; Capasso, Maria; Migliorati, Roberta; Martinsson, Tommy; Siani, Paolo; Nitsch, Lucio; Tonini, Gian Paolo

    2013-11-01

    Constitutional 11q deletion is a chromosome imbalance possibly found in MCA/MR patients analyzed for chromosomal anomalies. Its role in determining the phenotype depends on extension and position of deleted region. Loss of heterozygosity of 11q (region 11q23) is also associated with neuroblastoma, the most frequent extra cranial cancer in children. It represents one of the most frequent cytogenetic abnormalities observed in the tumor of patients with high-risk disease even if germline deletion of 11q in neuroblastoma is rare. Hereby, we describe a 18 months old girl presenting with trigonocephaly and dysmorphic facial features, including hypotelorism, broad depressed nasal bridge, micrognathia, synophrys, epicanthal folds, and with a stage 4 neuroblastoma without MYCN amplification, carrying a germline 11q deletion (11q14.1-q22.3), outside from Jacobsen syndrome and from neuroblastoma 11q critical regions. The role of 11q deletion in determining the clinical phenotype and its association with neuroblastoma development in the patient are discussed. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  7. Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture

    Science.gov (United States)

    Toyama-Sorimachi, Noriko; Tsujimura, Yusuke; Maruya, Mikako; Onoda, Atsuko; Kubota, Toshiyuki; Koyasu, Shigeo; Inaba, Kayo; Karasuyama, Hajime

    2004-01-01

    Here, we identified and characterized a Ly49 family member, designated as Ly49Q. The Ly49q gene encodes a 273-aa protein with an immunoreceptor tyrosine-based inhibitory motif (ITIM) at the N terminus of its cytoplasmic domain. We show that the ITIM of Ly49Q can recruit SHP-2 and SHP-1 in a tyrosine phosphorylation-dependent manner. In contrast to other known members of the Ly49 family, Ly49Q was found not to be expressed on NK1.1+ cells, but instead was detectable on virtually all Gr-1+ cells, such as myeloid precursors in bone marrow. Monocytes/macrophages also expressed low levels of Ly49Q, and the expression was enhanced by the treatment of cells with IFN-γ. Treatment of activated macrophages with anti-Ly49Q mAb induced rapid formation of polarized actin structures, showing filopodia-like structure on one side and lamellipodial-like structure on the other side. A panel of proteins became tyrosine-phosphorylated in myeloid cells when treated with the mAb. Induction of the phosphorylation depends on the ITIM of Ly49Q. Thus, Ly49Q has unique features different from other known Ly49 family members and appears to be involved in regulation of cytoskeletal architecture of macrophages through ITIM-mediated signaling. PMID:14732700

  8. Low Cost SU8 Based Above IC Process for High Q RF Power Inductors Integration

    International Nuclear Information System (INIS)

    Ghannam, A.; Bourrier, D.; Viallon, Ch.; Parra, Th.

    2011-01-01

    This paper presents a new process for integration of high-Q RF power inductors above low resistivity silicon substrates. The process uses the SU8 resin as a dielectric layer. The aim of using the SU8 is to form thick dielectric layer that can enhance the performance of the inductors. The flexibility of the process enables the possibility to realize complex shaped planar inductors with various dielectric and metal thicknesses to meet the requirements of the application. Q values of 55 at 5 GHz has been demonstrated for an inductance value of 0.8 nH using a 60 μm thick SU8 layer and 30 μm thick copper ribbons. (author)

  9. Investigations of environmental induced effects on AlQ3 thin films by AFM phase imaging

    International Nuclear Information System (INIS)

    Shukla, Vivek Kumar; Kumar, Satyendra

    2007-01-01

    Tris(8-hydroxyquinoline) metal complex (AlQ 3 ) is a widely used light-emitting material in organic light emitting devices (OLEDs). The environmental stability is still a major problem with OLEDs and needs further improvement. In this report, an additional feature of Atomic Force Microscopy (AFM) was exploited with the aim to understand the environmental induced effects and physical phenomenon involved on AlQ 3 thin films. We have used phase imaging to identify the presence of other aggregation phases formed after annealing the thin film in different ambient and after white light exposure. An enhanced photoluminescence intensity is observed for the samples annealed in oxygen near 100 deg. C. The enhanced photoluminescence is understood in terms of formation of a new aggregation phase. The phase change and the fraction of new phase is estimated by phase images taken by atomic force microscopy (AFM). Light induced effects on AlQ 3 films exposed to white light in air and vacuum are characterized by atomic force microscopy (AFM) for surface morphology and phases present. The AFM images indicate enhanced crystallinity for the vacuum exposed samples. The phase with increased lifetime and hence enhanced crystallinity for vacuum exposed films has also been found by time correlated single photon counting (TCSPC) measurements. To the best of our knowledge, this study is applied for the first time on this material with the combination of topography and phase imaging in atomic force microscopy (AFM). The major aim was to take advantage of the additional feature of AFM-mode over the conventionally used

  10. A.Q. Khan Nuclear Smuggling Network

    Directory of Open Access Journals (Sweden)

    Molly MacCalman

    2016-03-01

    Full Text Available Abdul Qadeer Khan, widely viewed as the father of Pakistan’s nuclear weapons program, was arrested on January 31, 2004 for his key role in the black market sale of nuclear technology and equipment to Iran, North Korea, Libya, and possibly others. A.Q. Khan’s nuclear smuggling network prospered throughout the 1980s and 1990s and was linked to middlemen and businesses in over 20 countries. The network offered buyers a menu of both technical expertise and materials with prices ranging from millions to hundreds of millions of dollars. The Khan network was ultimately exposed largely due to years of intelligence gathering by the United States and the United Kingdom. However, very few of the network’s members have been successfully prosecuted and the demand for nuclear material by both state and non-state actors continues. The exposure of Khan’s network confirmed that a non-state actor could procure and sell a turnkey nuclear weapons program to willing buyers.

  11. Paramagnetic centers in AlQ3

    International Nuclear Information System (INIS)

    Grecu, M. N.; Mirea, A.; Schwoerer, M.; Grecu, V. V.

    2004-01-01

    Since the discovery in 1987 of its electroluminescent properties, Alq 3 (tris(8-hydroxyquinoline)aluminum(III)) has become one of the most used material in OLEDs (organic light-emitting diodes). Many researches have been carried out for improving its quantum efficiency of light emission. In spite of these, rather many fundamental questions concerning its properties, their dependence on thermal and annealing treatments and crystalline structure remained unanswered. Recently, a significant blue shift of luminescent spectrum of a specially treated fraction (so called δ-phase) has been reported, increasing even more the interest in such a material. In this contribution we shall report on the existence of paramagnetic centers in different Alq 3 fractions formed by using the train sublimation method, as well as in those which have undergone various thermal treatments. Several centers have been observed by cw X- and Q-band EPR spectroscopy, corresponding to spin 1/2 and even spin 3/2. The spin Hamiltonian parameters are given, the temperature dependencies are reported and proposals for model structures are made. (author)

  12. Constacyclic codes over the ring F_q+v{F}_q+v2F_q and their applications of constructing new non-binary quantum codes

    Science.gov (United States)

    Ma, Fanghui; Gao, Jian; Fu, Fang-Wei

    2018-06-01

    Let R={F}_q+v{F}_q+v2{F}_q be a finite non-chain ring, where q is an odd prime power and v^3=v. In this paper, we propose two methods of constructing quantum codes from (α +β v+γ v2)-constacyclic codes over R. The first one is obtained via the Gray map and the Calderbank-Shor-Steane construction from Euclidean dual-containing (α +β v+γ v2)-constacyclic codes over R. The second one is obtained via the Gray map and the Hermitian construction from Hermitian dual-containing (α +β v+γ v2)-constacyclic codes over R. As an application, some new non-binary quantum codes are obtained.

  13. Behavior of IncQ Plasmids in Agrobacterium tumefaciens

    NARCIS (Netherlands)

    Hille, Jacques; Schilperoort, Rob

    1981-01-01

    Inc-Q plasmids were introduced into Agrobacterium tumefuciens, by mobilization from Escherichia coli with an Inc-P plasmid, or by transformation with purified plasmid DNA. It was found that they were stably maintained. The presence of an Inc-Q plasmid did not influence tumorigenicity. These results

  14. Was de uitbraak van Q-koorts een verrassing?

    NARCIS (Netherlands)

    Haalboom, A. F.

    2017-01-01

    The world's largest outbreak of Q fever swept the Netherlands between 2007 and 2010. The disease seemed to take us by surprise. Thousands of people fell ill, dozens of people died and patients continue to suffer from chronic Q fever even today. Eventually, tens of thousands of pregnant dairy goats

  15. Geometry of q-Exponential Family of Probability Distributions

    Directory of Open Access Journals (Sweden)

    Shun-ichi Amari

    2011-06-01

    Full Text Available The Gibbs distribution of statistical physics is an exponential family of probability distributions, which has a mathematical basis of duality in the form of the Legendre transformation. Recent studies of complex systems have found lots of distributions obeying the power law rather than the standard Gibbs type distributions. The Tsallis q-entropy is a typical example capturing such phenomena. We treat the q-Gibbs distribution or the q-exponential family by generalizing the exponential function to the q-family of power functions, which is useful for studying various complex or non-standard physical phenomena. We give a new mathematical structure to the q-exponential family different from those previously given. It has a dually flat geometrical structure derived from the Legendre transformation and the conformal geometry is useful for understanding it. The q-version of the maximum entropy theorem is naturally induced from the q-Pythagorean theorem. We also show that the maximizer of the q-escort distribution is a Bayesian MAP (Maximum A posteriori Probability estimator.

  16. Genetics Home Reference: 22q13.3 deletion syndrome

    Science.gov (United States)

    ... 5 links) Diagnostic Tests Drug Therapy Genetic Counseling Palliative Care Surgery and Rehabilitation Related Information How are genetic ... Veltman JA, de Vries BB. Molecular characterisation of patients with subtelomeric 22q ... L, Enns GM, Hoyme HE. Terminal 22q deletion syndrome: a newly recognized cause of ...

  17. q-deformed oscillators and D-branes on conifold

    International Nuclear Information System (INIS)

    Okuyama, Kazumi

    2009-01-01

    We study the q-deformed oscillator algebra acting on the wavefunctions of non-compact D-branes in the topological string on conifold. We find that the mirror B-model curve of conifold appears from the commutation relation of the q-deformed oscillators

  18. Using BMDP and SPSS for a Q factor analysis.

    Science.gov (United States)

    Tanner, B A; Koning, S M

    1980-12-01

    While Euclidean distances and Q factor analysis may sometimes be preferred to correlation coefficients and cluster analysis for developing a typology, commercially available software does not always facilitate their use. Commands are provided for using BMDP and SPSS in a Q factor analysis with Euclidean distances.

  19. The Q theory of investment : does uncertainty matter

    NARCIS (Netherlands)

    Hong Bo, [No Value

    1999-01-01

    This paper includes uncertainty in the Q-model of investment. A structural Q-type investment model is derived, which contains the information on uncertainty effects of random variables that affect the future profitability of a firm. We use a panel of 82 Dutch firms to test whether the presence of

  20. Reliability Analysis for Safety Grade PLC(POSAFE-Q)

    International Nuclear Information System (INIS)

    Choi, Kyung Chul; Song, Seung Whan; Park, Gang Min; Hwang, Sung Jae

    2012-01-01

    Safety Grade PLC(Programmable Logic Controller), POSAFE-Q, was developed recently in accordance with nuclear regulatory and requirements. In this paper, describe reliability analysis for digital safety grade PLC (especially POSAFE-Q). Reliability analysis scope is Prediction, Calculation of MTBF (Mean Time Between Failure), FMEA (Failure Mode Effect Analysis), PFD (Probability of Failure on Demand). (author)

  1. The existence of solutions of q-difference-differential equations.

    Science.gov (United States)

    Wang, Xin-Li; Wang, Hua; Xu, Hong-Yan

    2016-01-01

    By using the Nevanlinna theory of value distribution, we investigate the existence of solutions of some types of non-linear q-difference differential equations. In particular, we generalize the Rellich-Wittich-type theorem and Malmquist-type theorem about differential equations to the case of q-difference differential equations (system).

  2. Graphene Q-switched Yb:KYW planar waveguide laser

    NARCIS (Netherlands)

    Kim, Jun Wan; Choi, Sun Young; Aravazhi, S.; Pollnau, Markus; Griebner, Uwe; Petrov, Valentin; Bae, Sukang; Ahn, Kwang Jun; Yeom, Dong-Il; Rotermund, Fabian

    A diode-pumped Yb:KYW planar waveguide laser, single-mode Q-switched by evanescent-field interaction with graphene, is demonstrated for the first time. Few-layer graphene grown by chemical vapor deposition is transferred onto the top of a guiding layer, which initiates stable Q-switched operation in

  3. Q-feber som årsag til spontan abort

    DEFF Research Database (Denmark)

    Nielsen, Stine Yde; Mølbak, Kåre; Hjøllund, Niels Henrik

    2011-01-01

    the first weeks of her pregnancy, she handled birth by-products from cows with Q-fever. The Q-fever titres revealed that she was most likely infected in very early pregnancy. According to the literature, infection in the first trimester constitutes a specific risk of spontaneous abortion....

  4. Robot soccer action selection based on Q learning

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    This paper researches robot soccer action selection based on Q learning . The robot learn to activate particular behavior given their current situation and reward signal. We adopt neural network to implementations of Q learning for their generalization properties and limited computer memory requirements

  5. Data-Driven Learning of Q-Matrix

    Science.gov (United States)

    Liu, Jingchen; Xu, Gongjun; Ying, Zhiliang

    2012-01-01

    The recent surge of interests in cognitive assessment has led to developments of novel statistical models for diagnostic classification. Central to many such models is the well-known "Q"-matrix, which specifies the item-attribute relationships. This article proposes a data-driven approach to identification of the "Q"-matrix and estimation of…

  6. Q Vara juhtimiskoolitus "Kuidas karastus teras" / Annika Vaikla, Keiu Talve

    Index Scriptorium Estoniae

    Vaikla, Annika

    2007-01-01

    Kinnisvarafirma OÜ Q Vara töötajad pidid läbi viima Paide rahvusvahelise triatloni, mis oli läbiviijatele juhtimiskoolituseks. Küsimusele, kas juhtkonnal tekkis kiusatus sekkuda, vastab Q Vara juhatuse esimees Meelis Šokmann

  7. Hepatoprotective effect of taurine and coenzyme Q10 and their ...

    African Journals Online (AJOL)

    CoQ10) for mitigation of acrylamide- induced oxidative damage. . Method: Acrylamide (AA), TA and CoQ10 were administered orally to rats for 2 and 4 weeks. Sixty albino rats of either sex weighing 200 ± 5 were randomly divided into five groups; ...

  8. Mass spectra for q c q ¯ c ¯, s c s ¯ c ¯, q b q ¯ ¯, s b s ¯ ¯ tetraquark states with JP C=0++ and 2++

    Science.gov (United States)

    Chen, Wei; Chen, Hua-Xing; Liu, Xiang; Steele, T. G.; Zhu, Shi-Lin

    2017-12-01

    We have studied the mass spectra of the hidden-charm/bottom q c q ¯c ¯, s c s ¯c ¯ and q b q ¯b ¯, s b s ¯b ¯ tetraquark states with JP C=0++ and 2++ in the framework of QCD sum rules. We construct ten scalar and four tensor interpolating currents in a systematic way and calculate the mass spectra for these tetraquark states. The X*(3860 ) may be either an isoscalar tetraquark state or χc 0(2 P ). If the X*(3860 ) is a tetraquark candidate, our results prefer the 0++ option over the 2++ one. The X (4160 ) may be classified as either the scalar or tensor q c q ¯c ¯ tetraquark state, while the X (3915 ) favors a 0++ q c q ¯c ¯ or s c s ¯c ¯ tetraquark assignment over the tensor one. The X (4350 ) cannot be interpreted as a s c s ¯c ¯ tetraquark with either JP C=0++ or 2++.

  9. Exact solutions, energy, and charge of stable Q-balls

    Energy Technology Data Exchange (ETDEWEB)

    Bazeia, D.; Marques, M.A. [Universidade Federal da Paraiba, Departamento de Fisica, Joao Pessoa, PB (Brazil); Menezes, R. [Universidade Federal da Paraiba, Departamento de Ciencias Exatas, Rio Tinto, PB (Brazil); Universidade Federal de Campina Grande, Departamento de Fisica, Campina Grande, PB (Brazil)

    2016-05-15

    In this work we deal with nontopological solutions of the Q-ball type in two spacetime dimensions. We study models of current interest, described by a Higgs-like and other, similar potentials which unveil the presence of exact solutions. We use the analytic results to investigate how to control the energy and charge to make the Q-balls stable. (orig.)

  10. Q Vara toimetab Gildi selja taga / Jaana Pikalev

    Index Scriptorium Estoniae

    Pikalev, Jaana

    2010-01-01

    Q Vara tütarfirma aktsiad liikusid Celander Grupp OÜ tütarfirma Taevasmaa Kinnisvara omandusse. Q Vara enamusaktsionäri GA Gild Fund Management AS-i juhi Tõnu Peki väitel ei ole tehingu tagamaid nendega kooskõlastatud

  11. Q Vara võlakirjainvestorid saavad kergemalt hingata / Piret Reiljan

    Index Scriptorium Estoniae

    Reiljan, Piret, 1983-

    2008-01-01

    Kinnisvarakontsern Q Vara müüs omakapitali probleemide lahendamiseks Terminali laopargi ning teine suurtehing Riia kesklinnas on samuti lõpusirgel. Küsimustele vastab Q Vara omanik ja nõukogu liige Alo Lillepea. Vt. samas: Omanikud. Diagramm: Omakapital, kohustused

  12. Genetics Home Reference: proximal 18q deletion syndrome

    Science.gov (United States)

    ... characteristic features. Most cases of proximal 18q deletion syndrome are the result of a new (de novo) deletion and are not inherited from a ... J, Fox PT, Stratton RF, Perry B, Hale DE. Recurrent interstitial deletions of proximal 18q: a new syndrome involving expressive speech delay. Am J Med Genet ...

  13. Williams Syndrome and 15q Duplication: Coincidence versus Association.

    Science.gov (United States)

    Khokhar, Aditi; Agarwal, Swashti; Perez-Colon, Sheila

    2017-01-01

    Williams syndrome is a multisystem disorder caused by contiguous gene deletion in 7q11.23, commonly associated with distinctive facial features, supravalvular aortic stenosis, short stature, idiopathic hypercalcemia, developmental delay, joint laxity, and a friendly personality. The clinical features of 15q11q13 duplication syndrome include autism, mental retardation, ataxia, seizures, developmental delay, and behavioral problems. We report a rare case of a girl with genetically confirmed Williams syndrome and coexisting 15q duplication syndrome. The patient underwent treatment for central precocious puberty and later presented with primary amenorrhea. The karyotype revealed 47,XX,+mar. FISH analysis for the marker chromosome showed partial trisomy/tetrasomy for proximal chromosome 15q (15p13q13). FISH using an ELN -specific probe demonstrated a deletion in the Williams syndrome critical region in 7q11.23. To our knowledge, a coexistence of Williams syndrome and 15q duplication syndrome has not been reported in the literature. Our patient had early pubertal development, which has been described in some patients with Williams syndrome. However, years later after discontinuing gonadotropin-releasing hormone analogue treatment, she developed primary amenorrhea.

  14. Minimum Q Electrically Small Spherical Magnetic Dipole Antenna - Practice

    DEFF Research Database (Denmark)

    Kim, Oleksiy S.; Breinbjerg, Olav

    2009-01-01

    Practical aspects of applying a magnetic core to approach the Chu lower bound for the radiation Q factor of an electrically small magnetic dipole antenna are considered. It is shown that although a magnetic core does reduce the Q factor, its effect is not as strong as predicted by Wheeler...

  15. Q.C.D. estimates of hadronic cross sections

    International Nuclear Information System (INIS)

    Navelet, H.; Peschanski, R.

    1983-03-01

    Estimates for hadron-hadron cross-sections are made using the leading log approximation of Q.C.D. The rise of the total inelastic pp cross-sections at high energy is reproduced, thanks to the competition between the small parton-parton interaction and the large multiplicity of gluons predicted by Q.C.D

  16. Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance

    Energy Technology Data Exchange (ETDEWEB)

    Das, Kalyan; Martinez, Sergio E.; Arnold, Eddy

    2017-04-10

    HIV-1 reverse transcriptase (RT) is targeted by multiple drugs. RT mutations that confer resistance to nucleoside RT inhibitors (NRTIs) emerge during clinical use. Q151M and four associated mutations, A62V, V75I, F77L, and F116Y, were detected in patients failing therapies with dideoxynucleosides (didanosine [ddI], zalcitabine [ddC]) and/or zidovudine (AZT). The cluster of the five mutations is referred to as the Q151M complex (Q151Mc), and an RT or virus containing Q151Mc exhibits resistance to multiple NRTIs. To understand the structural basis for Q151M and Q151Mc resistance, we systematically determined the crystal structures of the wild-type RT/double-stranded DNA (dsDNA)/dATP (complex I), wild-type RT/dsDNA/ddATP (complex II), Q151M RT/dsDNA/dATP (complex III), Q151Mc RT/dsDNA/dATP (complex IV), and Q151Mc RT/dsDNA/ddATP (complex V) ternary complexes. The structures revealed that the deoxyribose rings of dATP and ddATP have 3'-endo and 3'-exo conformations, respectively. The single mutation Q151M introduces conformational perturbation at the deoxynucleoside triphosphate (dNTP)-binding pocket, and the mutated pocket may exist in multiple conformations. The compensatory set of mutations in Q151Mc, particularly F116Y, restricts the side chain flexibility of M151 and helps restore the DNA polymerization efficiency of the enzyme. The altered dNTP-binding pocket in Q151Mc RT has the Q151-R72 hydrogen bond removed and has a switched conformation for the key conserved residue R72 compared to that in wild-type RT. On the basis of a modeled structure of hepatitis B virus (HBV) polymerase, the residues R72, Y116, M151, and M184 in Q151Mc HIV-1 RT are conserved in wild-type HBV polymerase as residues R41, Y89, M171, and M204, respectively; functionally, both Q151Mc HIV-1 and wild-type HBV are resistant to dideoxynucleoside analogs.

  17. Matrix formulation of fractional supersymmetry and q-deformation

    Energy Technology Data Exchange (ETDEWEB)

    Benkaddour, I.

    2006-02-24

    Supersymmetry, which is the only non-trivial Z{sub 2} extension of the Poincare algebra, can be generalized to fractional supersymmetry, when the space time is smaller than 3. Since symmetries play an important role in physics; the principal task of quantum groups consist in extanding these standard symmetries to the deformed ones, which might be used in physics as well. This two aspects will be the main focus of this thesis. In this work, we discuss the matrix formulation of fractional supersymmetry, the q-deformation of KdV hierarchy systems and noncommutative geometry. In the first part fractional supersymmetry generated by more than one charge operator and those which can be described as a matrix model are studied. Using parafermionic field-theoretical methods, the fundamentals of two-dimensional fractional supersymmetry Q{sup k}=P are set up. Known difficulties induced by methods based on the U{sub q}(sl(2)) quantum group representations and noncommutative geometry are avoided in the parafermionic approach. Moreover, we find that fractional supersymmetric algebras are naturally realized as matrix models. The k=3 case is studied in detail. In the second part we will study the q-deformed algebra and the q-analogues of the generalised KdV hierarchy. We construct in this part the algebra of q-deformed pseudo-differential operators, shown to be an essential step toward setting up a q-deformed integrability program. In fact, using the results of this q-deformed algebra, we derive the q-analogues of the generalised KdV hierarchy. We focus in particular on the first leading orders of this q-deformed hierarchy, namely the q-KdV and q-Boussinesq integrable systems. We also present the q-generalisation of the conformal transformations of the currents u{sub n}, n{>=}2, and discuss the primary condition of the fields w{sub n}, n{>=}2, by using the Volterra gauge group transformations for the q-covariant Lax operators. In the last part we will discuss quantum groups and

  18. Characteristics of low-q disruptions in PBX

    International Nuclear Information System (INIS)

    Kaye, S.M.; Jahns, G.L.; Morris, A.W.

    1988-06-01

    The results of this study indicate that even within the relatively narrow low-q/sub /psi// operating space, there is a continuum in the characteristics of the low-q/sub /psi// disruptions with a primary dependence on the value of . While the ideal external kink instability may give rise to the growing oscillations that lead up to the ultimate disruption, the instabilities are weighted towards the edge only at the lowest-q/sub /psi// (≤ 3) and highest . At even slightly higher q/sub /psi//, the oscillations are also seen, at the same frequency, in the interior of the plasma. The results further indicate that effects outside the scope of ideal MHD theory may play a significant role in low-q/sub /psi// disruptions. 34 refs., 19 figs

  19. The Q-Slope Method for Rock Slope Engineering

    Science.gov (United States)

    Bar, Neil; Barton, Nick

    2017-12-01

    Q-slope is an empirical rock slope engineering method for assessing the stability of excavated rock slopes in the field. Intended for use in reinforcement-free road or railway cuttings or in opencast mines, Q-slope allows geotechnical engineers to make potential adjustments to slope angles as rock mass conditions become apparent during construction. Through case studies across Asia, Australia, Central America, and Europe, a simple correlation between Q-slope and long-term stable slopes was established. Q-slope is designed such that it suggests stable, maintenance-free bench-face slope angles of, for instance, 40°-45°, 60°-65°, and 80°-85° with respective Q-slope values of approximately 0.1, 1.0, and 10. Q-slope was developed by supplementing the Q-system which has been extensively used for characterizing rock exposures, drill-core, and tunnels under construction for the last 40 years. The Q' parameters (RQD, J n, J a, and J r) remain unchanged in Q-slope. However, a new method for applying J r/ J a ratios to both sides of potential wedges is used, with relative orientation weightings for each side. The term J w, which is now termed J wice, takes into account long-term exposure to various climatic and environmental conditions such as intense erosive rainfall and ice-wedging effects. Slope-relevant SRF categories for slope surface conditions, stress-strength ratios, and major discontinuities such as faults, weakness zones, or joint swarms have also been incorporated. This paper discusses the applicability of the Q-slope method to slopes ranging from less than 5 m to more than 250 m in height in both civil and mining engineering projects.

  20. New exponential, logarithm and q-probability in the non-extensive statistical physics

    OpenAIRE

    Chung, Won Sang

    2013-01-01

    In this paper, a new exponential and logarithm related to the non-extensive statistical physics is proposed by using the q-sum and q-product which satisfy the distributivity. And we discuss the q-mapping from an ordinary probability to q-probability. The q-entropy defined by the idea of q-probability is shown to be q-additive.

  1. Comparative Study of Customer Satisfaction for Four Service Center by Using House of Quality (HoQ)

    International Nuclear Information System (INIS)

    Fazila Said; Mohammad Nasir Saluddin

    2012-01-01

    The comparative study between four service center was constructed from the development of House of Quality (HoQ). HoQ is a simple and attractive service innovation tool which can be used to directly show a comprehensive information which contained the voice of customer (VOC), technical response, technical correlation and matrix relationship. The indirect information is a report on technical and planning part which shows the comparison between four service center. This study revealed that the information from HoQ with further discussion on planning part which can be used to assist management in knowing the overall detail information of service center achievement and recognizes the solution for unsatisfied customer through priority improvement activity to enhance the customer satisfaction in future. (author)

  2. Rotational stabilization of q < 1 modes

    International Nuclear Information System (INIS)

    Waelbroeck, F.L.; Aydemir, A.Y.

    1996-01-01

    Analyses of high performance discharges with central safety factor below unity have shown that the ideal Magnetohydrodynamic stability threshold for the n=1 kink mode is often violated with impunity. For TFTR (Tokamak Fusion Test Reactor) supershots, the experimental observations can be explained by diamagnetic stabilization of the reconnecting model provided that the fluid free energy is suitably reduced by trapped particle effects. For the broader profiles typical of other high confinement regimes, however, diamagnetic effects cannot account for the experimental results. Furthermore, there is evidence that the Mercier stability condition can also be violated in some cases. Here, we show that toroidal rotation of the plasma can stabilize the kink mode even in the presence of resistivity in configurations that would otherwise be ideally unstable. Two effects can be distinguished. The first effect consists in a reduction of the ideal driving energy. This can be understood in view of the fact that, to a good approximation, the internal kink is a rigid body displacement combining a tilt of the plasma inside the q = 1 surface with a translation along the tilt axis. In the presence of rotation, this displacement must be accompanied by a precessional motion so as to conserve angular momentum. The kinetic energy of the precessional motion must be extracted from the energy driving the displacement. The second effect of rotation is to resolve the Alfven singularity. This is a consequence of the pressure perturbation caused by the equilibrium variation of the entropy within the flux surfaces. It results in the stabilization of resistive as well as weak ideal instabilities, including Mercier modes. For rotationally stabilized equilibria, it also implies the presence of a neutrally stable mode with frequency of the order of the growth rate of the internal kink

  3. Q-switched laser tattoo removal

    Directory of Open Access Journals (Sweden)

    Viljem H. topčič

    2013-10-01

    Full Text Available Background: Decorative tattooing gained popularity in many western countries throughout the 1990s. Some estimates show that approximately 10 % of men in the United States already have tattoos. However, tattoos often become a personal regret. As recent surveys suggest, 17 % of people that have obtained a tattoo and more than 50 % of adults over the age of 40 in the United States of America consider having them removed. The same trend can be observed in our country as well. Laser therapy is the gold standard for tattoo removal. In Slovenia, laser tattoo removal therapy is available and widely accessible. There is a wide range of facilities offering laser tattoo removal, ranging from different private clinics to beauty salons. Different facilities use different lasers, but not all lasers, however, are optimal for successful and complete tattoo removal, as inappropriate use can cause many unwanted side effects.Methods: Eleven (11 patients (2 men and 9 women requesting tattoo removal were treated in our department. When treating our patients, we used Fotona’s QX MAX quality-switched Nd:YAG laser which offers four different wavelengths in a single system; 1064 nm Nd:YAG was used to treat and remove dark pigments, 532 nm KTP for red, tan-colored, purple and orange tattoo inks, 650 nm dye for green tattoo inks and 585 nm dye for sky-blue colored inks.Results: Satisfactory tattoo removal was achieved in all patients treated. Patients were very satisfied with the success and the number of treatments needed for tattoo removal. There were mild unwanted side effects and the pain was moderate. The average number of treatments required for complete tattoo removal was less than 7, ranging from 3 to 21 treatments. Patients’ satisfaction with tattoo removal was estimated at 5.2 (on a scale from 1 to 6.Conclusions: Our study showed that Q-switched lasers successfully remove tattoo ink, however several treatments are required for satisfactory tattoo removal

  4. NASA Brief: Q-Thruster Physics

    Science.gov (United States)

    White, Harold

    2013-01-01

    Q-thrusters are a low-TRL form of electric propulsion that operates on the principle of pushing off of the quantum vacuum. A terrestrial analog to this is to consider how a submarine uses its propeller to push a column of water in one direction, while the sub recoils in the other to conserve momentum -the submarine does not carry a "tank" of sea water to be used as propellant. In our case, we use the tools of Magnetohydrodynamics (MHD) to show how the thruster pushes off of the quantum vacuum which can be thought of as a sea of virtual particles -principally electrons and positrons that pop into and out of existence, and where fields are stronger, there are more virtual particles. The idea of pushing off the quantum vacuum has been in the technical literature for a few decades, but to date, the obstacle has been the magnitude of the predicted thrust which has been derived analytically to be very small, and therefore not likely to be useful for human spaceflight. Our recent theoretical model development and test data suggests that we can greatly increase the magnitude of the negative pressure of the quantum vacuum and generate a specific force such that technology based on this approach can be competitive for in-space propulsion approx. 0.1N/kW), and possibly for terrestrial applications (approx. 10N/kW). As an additional validation of the approach, the theory allows calculation of physics constants from first principles: Gravitational constant, Planck constant, Bohr radius, dark energy fraction, electron mass.

  5. The qTSN positive effect on panicle and flag leaf size of rice is associated with an early down-regulation of tillering

    Directory of Open Access Journals (Sweden)

    Dewi Erika eAdriani

    2016-01-01

    Full Text Available The qTSN4 was identified as rice QTL (Quantitative Traits Locus increasing total spikelet number per panicle and flag leaf area but potentially reducing panicle number depending on the environment. So far, this trade-off was mainly observed at grain maturity and not specifically studied in details, limiting the apprehension of the agronomic interest of qTSN4. This study aimed to understand the effect of qTSN4 and of the environment on panicle sizing, its trade-off with panicle number and finally plant grain production. It compared two high yielding genotypes to their Near Isogenic Lines (NIL carrying either QTL qTSN4 or qTSN12, two distinct QTLs contributing to the enlarged panicle size, thereafter designated as qTSN. Traits describing C sink (organ appearance rate, size, biomass and source (leaf area, photosynthesis, sugar availability were dynamically characterized along plant and/or panicle development within two trials (greenhouse, field, each comparing two treatments contrasting for plant access to light (with or without shading, high or low planting densities. The positive effect of qTSN on panicle size and flag leaf area of the main tiller was confirmed. More precisely, it could be shown that qTSN increased leaf area and internode cross-section, and in some cases of the photosynthetic rate and starch reserves, of the top 3-4 phytomers of the main tiller. This was accompanied by an earlier tillering cessation, that coincided with the initiation of these phytomers, and an enhanced of panicle size on the main tiller. Plant leaf area at flowering was not affected by qTSN but fertile tiller number was reduced to an extent that depended on the environment. Accordingly, plant grain production was enhanced by qTSN only under shading in the greenhouse experiment, where panicle number was not affected and photosynthesis and starch storage in internodes was enhanced. The effect of qTSN on rice phenotype was thus expressed before panicle initiation

  6. Patients Carrying 9q31.1-q32 Deletion Share Common Features with Cornelia de Lange Syndrome

    Directory of Open Access Journals (Sweden)

    Ruixue Cao

    2015-01-01

    Full Text Available Background: Cornelia de Lange Syndrome (CdLS is a rare but severe clinically heterogeneous developmental disorder characterized by facial dysmorphia, growth and cognitive retardation, and abnormalities of limb development. Objectives: To determine the pathogenesis of a patient with CdLS. Methods: We studied a patient with CdLS by whole exome sequencing, karyotyping and Agilent CGH Array. The results were confirmed by quantitative real-time PCR analysis of the patient and her parents. Further comparison of our patient and cases with partially overlapping deletions retrieved from the literature and databases was undertaken. Results: Whole exome sequencing had excluded the mutation of cohesion genes such as NIPBL,SMC1A and SMC3. The result of karyotyping showed a deletion of chromosome 9q31.1-q32 and the result of Agilent CGH Array further displayed a 12.01-Mb region of deletion at chromosome bands 9q31.1-q32. Reported cases with the deletion of 9q31.1-q32 share similar features with our CdLS patient. One of the genes in the deleted region, SMC2, belongs to the Structural Maintenance of Chromosomes (SMC family and regulates gene expression and DNA repair. Conclusions: Patients carrying the deletion of 9q31.1-q32 showed similar phenotypes with CdLS.

  7. The del(2)(q32.2q33) deletion syndrome defined by clinical and molecular characterization of four patients.

    NARCIS (Netherlands)

    Buggenhout, G.J.C.M. van; Ravenswaaij-Arts, C.M.A. van; Maas, N.; Thoelen, R.; Vogels, A.; Smeets, D.F.C.M.; Salden, I.; Matthijs, G.; Fryns, J.P.; Vermeesch, J.

    2005-01-01

    We report four patients with an interstitial deletion of chromosome 2q32-->2q33. They presented similar clinical findings including pre- and postnatal growth retardation, distinct facial dysmorphism, thin and sparse hair and fair built, micrognathia, cleft or high palate, relative macroglossia,

  8. Quantitative (q)AOP for aromatase inhibition as case study to advance qAOP development practices

    Science.gov (United States)

    Here we describe how “read across” of a quantitative adverse outcome pathway (qAOP) developed with data for one chemical can be used to screen impacts of other chemicals. We developed a qAOP starting with inhibition of CYP19A (aromatase) in fathead minnows (FHM) as th...

  9. On the Convergence of Q-OR and Q-MR Krylov Methods for Solving Nonsymmetric Linear Systems

    Czech Academy of Sciences Publication Activity Database

    Duintjer Tebbens, Jurjen; Meurant, G.

    2016-01-01

    Roč. 56, č. 1 (2016), s. 77-97 ISSN 0006-3835 R&D Projects: GA ČR GA13-06684S Institutional support: RVO:67985807 Keywords : Krylov method * Q-OR method * Q-MR method * BiCG * QMR * CMRH * eigenvalue influence * prescribed convergence Subject RIV: BA - General Mathematics Impact factor: 1.670, year: 2016

  10. Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders

    DEFF Research Database (Denmark)

    Isles, Anthony R; Ingason, Andrés; Lowther, Chelsea

    2016-01-01

    Duplications at 15q11.2-q13.3 overlapping the Prader-Willi/Angelman syndrome (PWS/AS) region have been associated with developmental delay (DD), autism spectrum disorder (ASD) and schizophrenia (SZ). Due to presence of imprinted genes within the region, the parental origin of these duplications m...

  11. Refinement of genotype-phenotype correlation in 18 patients carrying a 1q24q25 deletion

    DEFF Research Database (Denmark)

    Chatron, Nicolas; Haddad, Véronique; Andrieux, Joris

    2015-01-01

    of different sizes (490 kb to 20.95 Mb) localized within chromosome bands 1q23.3-q31.2 (chr1:160797550-192912120, hg19). The 490 kb deletion is the smallest deletion reported to date associated with this phenotype. We delineated three regions that may contribute to the phenotype: a proximal one (chr1...

  12. Influence of Alkali Metal Substitution on the Phase Transition Behavior of CsGaQ2 (Q = S, Se

    Directory of Open Access Journals (Sweden)

    Daniel Friedrich

    2017-12-01

    Full Text Available The formation of solid solution series Cs1−xMxGaQ2-mC64 (M = K, Rb; Q = S, Se; x = 0–1 was studied by X-ray diffraction and spectroscopic methods, revealing a complete miscibility of CsGaQ2-mC64 with RbGaQ2 and KGaSe2, and a large miscibility gap with KGaS2. All solid solution members exhibit similar Raman spectra, indicating the covalent Ga-Q bonding character. The similar optical band gaps likewise further contribute to this conclusion. Up to a certain degree of substitution, these solid solutions undergo a phase transition similar to CsGaQ2-mC64. The influence of the substitution parameter x on phase transition process was investigated in situ using high-temperature X-ray powder diffraction experiments. Phase-pure solid solutions of the high-temperature polymorphs Cs1−xMxGaQ2-mC16 were obtained up to xmax(K = 0.1 and xmax(Rb = 0.3. The crystal structures of these new CsGaQ2-mC16 analogous high-temperature phases were refined from synchrotron diffraction data by Rietveld-refinement.

  13. [Acute myeloid leukemia with monosomy 7 and inv(3)(q21q26.2) complicated with central diabetes insipidus].

    Science.gov (United States)

    Nanno, Satoru; Hagihara, Kiyoyuki; Sakabe, Manami; Okamura, Hiroshi; Inaba, Akiko; Nagata, Yuki; Nishimoto, Mitsutaka; Koh, Hideo; Nakao, Yoshitaka; Nakane, Takahiko; Nakamae, Hirohisa; Shimono, Taro; Hino, Masayuki

    2013-04-01

    A 20-year-old female presented with thirst, polyposia, and polyuria and was referred to our hospital because of leukocytosis and anemia. Bone marrow aspiration revealed 66.8% myeloperoxidase-positive blasts and trilineage myelodysplasia. The karyotype was 45, XX, inv(3)(q21q26.2), -7[19]. Therefore, a diagnosis of AML with inv(3)(q21q26.2) complicated by -7 was made. Moreover, hyposthenuria and a low anti-diuretic hormone (ADH) level were observed. Although cerebrospinal fluid analysis was normal, magnetic resonance imaging (MRI) revealed the absence of hyperintensity in the neurohypophysis in T1-weighted images. Therefore, she was also diagnosed with diabetes insipidus. After she was administered a desmopressin nasal spray, the volume of urine produced decreased. Following treatment with second induction therapy containing high-dose cytarabine for AML, she achieved complete remission in the bone marrow. Moreover, when the abnormality on MRI and the volume of urine were normalized, she discontinued desmopressin. Although diabetes insipidus is a rare complication of AML, the majority of AML patients who have diabetes insipidus have the abnormal karyotypes with inv(3)(q21q26.2)/t(3;3)(q21;q26.2) and monosomy 7. Further study is required to clarify the pathogenesis and develop a strategy for the treatment of this category of AML.

  14. Criticality in the configuration-mixed interacting boson model: (1) U(5)-Q(χ)Q(χ) mixing

    International Nuclear Information System (INIS)

    Hellemans, V.; Van Isacker, P.; De Baerdemacker, S.; Heyde, K.

    2007-01-01

    The case of U(5)-Q(χ)Q(χ) mixing in the configuration-mixed interacting boson model is studied in its mean-field approximation. Phase diagrams with analytical and numerical solutions are constructed and discussed. Indications for first-order and second-order shape phase transitions can be obtained from binding energies and from critical exponents, respectively

  15. Fine mapping of the human renal oncocytoma-associated translocation (5;11)(q35;q13) breakpoint

    NARCIS (Netherlands)

    Sinke, RJ; Dijkhuizen, T; Janssen, B; Weghuis, DO; Merkx, G; vandenBerg, E; Schuuring, E; Meloni, AM; deJong, B; vanKessel, AG

    1997-01-01

    Recent cytogenetic analysis of a series of human renal oncocytomas revealed the presence of a recurring chromosomal translocation (5;11)(q35;q13) as sole anomaly in a subset of the tumors. The molecular characterization of this translocation was initiated using two primary t(5;11)-positive renal

  16. Common variants at 12q15 and 12q24 are associated with infant head circumference

    DEFF Research Database (Denmark)

    Taal, H Rob; St Pourcain, Beate; Thiering, Elisabeth

    2012-01-01

    To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication s......q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life....

  17. Breeding of Coenzyme Q10 Produced Strain by Low-Energy Ion Implantation and Optimization of Coenzyme Q10 Fermentation

    International Nuclear Information System (INIS)

    Xu Dejun; Zheng Zhiming; Wang Peng; Wang Li; Yuan Hang; Yu Zengliang

    2008-01-01

    In order to increase the production efficiency of coenzyme Q 10 , the original strain Agrobacterium tumefaciens ATCC 4452 was mutated by means of Nitrogen ions implantation. A mutant strain, ATX 12, with high contents of coenzyme Q 10 was selected. Subsequently, the conditions such as carbohydrate concentration, nitrogen source concentration, inoculum's size, seed age, aeration and temperature which might affect the production of CoQ 10 were investigated in detail. Under optimal conditions, the maximum concentration of the intracellular CoQ 10 reached 200.3 mg/L after 80 h fed-batch fermentation, about 245% increasing in CoQ 10 production after ion implantation, compared to the original strain. (ion beam bioengineering)

  18. Understanding the impact of 1q21.1 copy number variant

    Directory of Open Access Journals (Sweden)

    Harvard Chansonette

    2011-08-01

    Full Text Available Abstract Background 1q21.1 Copy Number Variant (CNV is associated with a highly variable phenotype ranging from congenital anomalies, learning deficits/intellectual disability (ID, to a normal phenotype. Hence, the clinical significance of this CNV can be difficult to evaluate. Here we described the consequences of the 1q21.1 CNV on genome-wide gene expression and function of selected candidate genes within 1q21.1 using cell lines from clinically well described subjects. Methods and Results Eight subjects from 3 families were included in the study: six with a 1q21.1 deletion and two with a 1q21.1 duplication. High resolution Affymetrix 2.7M array was used to refine the 1q21.1 CNV breakpoints and exclude the presence of secondary CNVs of pathogenic relevance. Whole genome expression profiling, studied in lymphoblast cell lines (LBCs from 5 subjects, showed enrichment of genes from 1q21.1 in the top 100 genes ranked based on correlation of expression with 1q21.1 copy number. The function of two top genes from 1q21.1, CHD1L/ALC1 and PRKAB2, was studied in detail in LBCs from a deletion and a duplication carrier. CHD1L/ALC1 is an enzyme with a role in chromatin modification and DNA damage response while PRKAB2 is a member of the AMP kinase complex, which senses and maintains systemic and cellular energy balance. The protein levels for CHD1L/ALC1 and PRKAB2 were changed in concordance with their copy number in both LBCs. A defect in chromatin remodeling was documented based on impaired decatenation (chromatid untangling checkpoint (DCC in both LBCs. This defect, reproduced by CHD1L/ALC1 siRNA, identifies a new role of CHD1L/ALC1 in DCC. Both LBCs also showed elevated levels of micronuclei following treatment with a Topoisomerase II inhibitor suggesting increased DNA breaks. AMP kinase function, specifically in the deletion containing LBCs, was attenuated. Conclusion Our studies are unique as they show for the first time that the 1q21.1 CNV not only

  19. Electrophysiological characteristics of a SCN5A voltage sensors mutation R1629Q associated with Brugada syndrome.

    Directory of Open Access Journals (Sweden)

    Zhipeng Zeng

    Full Text Available Brugada syndrome (BrS is an inherited arrhythmogenic syndrome leading to sudden cardiac death, partially associated with autosomal dominant mutations in SCN5A, which encodes the cardiac sodium channel alpha-subunit (Nav1.5. To date some SCN5A mutations related with BrS have been identified in voltage sensor of Nav1.5. Here, we describe a dominant missense mutation (R1629Q localized in the fourth segment of domain IV region (DIV-S4 in a Chinese Han family. The mutation was identified by direct sequencing of SCN5A from the proband's DNA. Co-expression of Wild-type (WT or R1629Q Nav1.5 channel and hβ1 subunit were achieved in human embryonic kidney cells by transient transfection. Sodium currents were recorded using whole cell patch-clamp protocols. No significant changes between WT and R1629Q currents were observed in current density or steady-state activation. However, hyperpolarized shift of steady-state inactivation curve was identified in cells expressing R1629Q channel (WT: V1/2 = -81.1 ± 1.3 mV, n = 13; R1629Q: V1/2 = -101.7 ± 1.2 mV, n = 18. Moreover, R1629Q channel showed enhanced intermediate inactivation and prolonged recovery time from inactivation. In summary, this study reveals that R1629Q mutation causes a distinct loss-of-function of the channel due to alter its electrophysiological characteristics, and facilitates our understanding of biophysical mechanisms of BrS.

  20. New evidences of neurotoxicity of aroclor 1254 in mice brain: potential of coenzyme q10 in abating the detrimental outcomes

    Directory of Open Access Journals (Sweden)

    Anuradha Majumdar

    2014-03-01

    Full Text Available Objectives The present subacute study was designed to evaluate the effect of coenzyme Q 10 (CoQ10 in the 28 days aroclor 1254 exposure induced oxidative stress in mice brain. Methods Biochemical estimations of brain lipid peroxidation (LPO, reduced glutathione (GSH, and activities of superoxide dismutase (SOD, catalase (CAT, glutathione peroxidase (GPx and acetyl cholinesterase (AChE, and histopathological investigations of brain tissue were carried out. Results Oral exposure of aroclor 1254 (5 mg/kg led to significant decrease in levels of GSH, and activities of SOD, CAT, GPx, and AChE, and increase in LPO. These aberrations were restored by CoQ10 (10 mg/kg, intraperitoneal injection [IP]. This protection offered was comparable to that of L-deprenyl (1 mg/kg, IP which served as a reference standard. Conclusions Aroclor 1254 exposure hampers the activities of various antioxidant enzymes and induces oxidative stress in the brains of Swiss albino mice. Supplementation of CoQ10 abrogates these deleterious effects of aroclor 1254. CoQ10 also apparently enhanced acetyl cholinesterase activity which reflects its influence on the cholinergic system.

  1. LnqR, a TetR-family transcriptional regulator, positively regulates lacticin Q production in Lactococcus lactis QU 5.

    Science.gov (United States)

    Iwatani, Shun; Ishibashi, Naoki; Flores, Floirendo P; Zendo, Takeshi; Nakayama, Jiro; Sonomoto, Kenji

    2016-09-01

    Lacticin Q is an unmodified leaderless bacteriocin produced by Lactococcus lactis QU 5. It has been revealed that the production and self-immunity of lacticin Q are facilitated by a gene cluster lnqQBCDEF The gene for a putative TetR-family transcriptional regulator, termed lnqR, was found nearby the lnqQBCDEF cluster, but its involvement in lacticin Q biosynthesis remained unknown. In this study, we created an LnqR-overexpressing QU 5 recombinant by using lactococcal constitutive promoter P32 The recombinant QU 5 showed enhanced production of and self-immunity to lacticin Q. RT-PCR analysis has revealed that an overexpression of LnqR increases the amounts of lnqQBCDEF transcripts, and these six genes are transcribed as an operon in a single transcriptional unit. Interestingly, LnqR expression and thus lacticin Q production by L. lactis QU 5 was found temperature dependent, while LnzR, an LnqR-homologue, in L. lactis QU 14 was expressed in a similar but not identical manner to LnqR, resulting in dissimilar bacteriocin productivities by these strains. This report demonstrates LnqR as the first TetR-family transcriptional regulator involved in LAB bacteriocin biosynthesis and that, as an exceptional case of TetR-family regulators, LnqR positively regulates the transcription of these biosynthetic genes. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  2. Self-Nanoemulsifying Drug Delivery System of Coenzyme (Q10) with Improved Dissolution, Bioavailability, and Protective Efficiency on Liver Fibrosis.

    Science.gov (United States)

    Khattab, Abeer; Hassanin, Lobna; Zaki, Nashwah

    2017-07-01

    The aim of our investigation is to develop and characterize self-nanoemulsifying drug delivery systems (SNEDDS) of CoQ 10 to improve its water solubility, dissolution rate, and bioavailability, and then evaluate its biochemical and physiological effect on liver cirrhosis in rats compared with CoQ 10 powder. SNEDDS are isotropic and thermodynamically stable mixture of oil, surfactant, co-surfactant, and drug that form an oil/water nanoemulsion when added to aqueous phases with soft agitation. Upon administration, self-nanoemulsifying system becomes in contact with gastrointestinal fluid and forms o/w nanoemulsion by the aid of gastrointestinal motility. When the nanoemulsion is formed in the gastrointestinal tract, it presents the drug in a solubilized form inside small nano-sized droplets that provide a large surface area for enhancing the drug release and absorption. Solubility of CoQ 10 in various oils, surfactants, and co-surfactants were studied to identify the components of SNEDDS; pseudo-ternary phase diagrams were plotted to identify the efficient self-emulsifying regions. CoQ 10 -loaded SNEDDS were prepared using isopropyl myristate as oil; Cremophor El, Labrasol, or Tween80 as surfactant; and Transcutol as co-surfactant. The amount of CoQ 10 in each vehicle was 3%. The formulations that passed thermostability evaluation test were assessed for particle size analysis, morphological characterization, refractive index, zeta potential, viscosity, electroconductivity, drug release profile, as well as ex vivo permeability. Pharmacokinetics and hepatoprotective efficiency of the optimized SNEDDS of CoQ 10 compared with CoQ 10 suspension were performed. Results showed that all optimized formulae have the ability to form a good and stable nanoemulsion when diluted with water; the mean droplet size of all formulae was in the nanometric range (11.7-13.5 nm) with optimum polydispersity index values (0.2-0.21). All formulae showed negative zeta potential (-11.3 to -17

  3. Hematological abnormalities and 22q11.2 deletion syndrome

    Directory of Open Access Journals (Sweden)

    Rafael Fabiano Machado Rosa

    2011-01-01

    Full Text Available The 22q11.2 deletion syndrome (22q11DS is a common genetic disease characterized by broad phenotypic variability. Despite the small number of studies describing hematological alterations in individuals with 22q11DS, it appears that these abnormalities are more frequent than previously imagined. Thus, the objective of our study was to report on a patient with 22q11DS presenting thrombocytopenia and large platelets and to review the literature. The patient, a 13-year-old boy, was originally evaluated due to craniofacial dysmorphia and speech delay. He also had a history of behavioral changes, neuropsychomotor delay and recurrent otitis/sinusitis. The identification of a 22q11.2 microdeletion by fluorescent in situ hybridization diagnosed the syndrome. Despite his hematological alterations, he only had a history of epistaxis and bruising of the upper and lower limbs. Assessments of the prothrombin time, thrombin time, partial thromboplastin time, bleeding time, fibrinogen levels and platelet aggregation (including the ristocetin induced platelet aggregation test were all normal. Hematological alterations observed in 22q11DS are directly related to the genetic disorder itself (especially in respect to deletion of the GPIb gene and secondary to some clinical findings, such as immunodeficiency. Macrothrombocytopenia is increasingly being considered a feature of the broad spectrum of 22q11DS and may potentially be a clinical marker for the syndrome.

  4. Hybrid mesons (Q anti Qg) in N anti N annihilation

    International Nuclear Information System (INIS)

    Dover, C.B.; Gutsche, T.; Faessler, A.

    1993-09-01

    N anti N annihilation reactions provide exciting possibilities to study mesonic resonances beyond the usual Q anti Q spectrum. Particularly the search for Q anti Qg mesons containing an explicit dynamical excitation of the gluon field is not promising, since hybrids are predicted to display unique features: exotic quantum numbers (J πC ) and dynamical selection rules for their decay modes. The authors have investigated the possibility of producing hybrids from p anti p atomic states in reactions of the type N anti N(L= 0,1) → π + Q anti Qg. Production rates for hybrid mesons are found to display a strong dependence on the quantum numbers and kinematical factors associated with the transition. The dependence on the orbital angular momentum L of the p anti p atomic state, accessible in p anti p annihilation at rest, would provide a striking signature for the production of hybrids. In estimating branching ratios for the formation of Q anti Qg hybrid mesons in N anti N annihilation reactions at rest, the authors have employed a microscopic model with constituent quarks and gluons in analogy to the annihilation model for the production of Q anti Q mesons

  5. Dielectric spectroscopy of the SmQ* phase

    Science.gov (United States)

    Perkowski, P.; Bubnov, A.; Piecek, W.; Ogrodnik, K.; Hamplová, V.; Kašpar, M.

    2011-11-01

    Liquid crystal possessing two biphenyl moieties in the molecular core and lateral chlorine substitution far from the chiral chain has been studied by dielectric spectroscopy. On cooling from the isotropic phase, the material possesses the frustrated smectic Q* (SmQ*) and SmCA* phases. It has been confirmed by dielectric spectroscopy that the SmQ* phase can be related to the SmCA* anti-ferroelectric phase. However, only one relaxation process has been observed in the SmQ* phase, while in the SmCA*, two relaxations are clearly detectable. It seems that the mode found in the SmQ* can be connected with high-frequency anti-phase mode observed in the SmCA* phase. Its relaxation frequency is similar to PH relaxation frequency, but is weaker. The same relaxation has been observed even a few degrees above the SmQ*-Iso phase transition. Another explanation for the mode detected in SmQ* and isotropic phases can be molecular motions around short molecular axis.

  6. Braided affine geometry and q-analogs of wave operators

    International Nuclear Information System (INIS)

    Gurevich, Dimitri; Saponov, Pavel

    2009-01-01

    The main goal of this review is to compare different approaches to constructing the geometry associated with a Hecke type braiding (in particular, with that related to the quantum group U q (sl(n))). We place emphasis on the affine braided geometry related to the so-called reflection equation algebra (REA). All objects of such a type of geometry are defined in the spirit of affine algebraic geometry via polynomial relations on generators. We begin by comparing the Poisson counterparts of 'quantum varieties' and describe different approaches to their quantization. Also, we exhibit two approaches to introducing q-analogs of vector bundles and defining the Chern-Connes index for them on quantum spheres. In accordance with the Serre-Swan approach, the q-vector bundles are treated as finitely generated projective modules over the corresponding quantum algebras. Besides, we describe the basic properties of the REA used in this construction and compare different ways of defining q-analogs of partial derivatives and differentials on the REA and algebras close to them. In particular, we present a way of introducing a q-differential calculus via Koszul type complexes. The elements of the q-calculus are applied to defining q-analogs of some relativistic wave operators. (topical review)

  7. Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice

    International Nuclear Information System (INIS)

    Fouad, Amr A.; Al-Sultan, Ali Ibrahim; Refaie, Shereen M.; Yacoubi, Mohamed T.

    2010-01-01

    The nephroprotective effect of coenzyme Q10 was investigated in mice with acute renal injury induced by a single i.p. injection of cisplatin (5 mg/kg). Coenzyme Q10 treatment (10 mg/kg/day, i.p.) was applied for 6 consecutive days, starting 1 day before cisplatin administration. Coenzyme Q10 significantly reduced blood urea nitrogen and serum creatinine levels which were increased by cisplatin. Coenzyme Q10 significantly compensated deficits in the antioxidant defense mechanisms (reduced glutathione level and superoxide dismutase activity), suppressed lipid peroxidation, decreased the elevations of tumor necrosis factor-α, nitric oxide and platinum ion concentration, and attenuated the reductions of selenium and zinc ions in renal tissue resulted from cisplatin administration. Also, histopathological renal tissue damage mediated by cisplatin was ameliorated by coenzyme Q10 treatment. Immunohistochemical analysis revealed that coenzyme Q10 significantly decreased the cisplatin-induced overexpression of inducible nitric oxide synthase, nuclear factor-κB, caspase-3 and p53 in renal tissue. It was concluded that coenzyme Q10 represents a potential therapeutic option to protect against acute cisplatin nephrotoxicity commonly encountered in clinical practice.

  8. Analysis of the QQ anti Q anti Q tetraquark states with QCD sum rules

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Zhi-Gang [North China Electric Power University, Department of Physics, Baoding (China)

    2017-07-15

    In this article, we study the J{sup PC} = 0{sup ++} and 2{sup ++} QQ anti Q anti Q tetraquark states with the QCD sum rules, and we obtain the predictions M{sub X(cc} {sub anti} {sub c} {sub anti} {sub c,0}{sup {sub +}{sub +)}} =5.99 ± 0.08 GeV, M{sub X(cc} {sub anti} {sub c} {sub anti} {sub c,2}{sup {sub +}{sub +)}} = 6.09 ± 0.08 GeV, M{sub X(bb} {sub anti} {sub b} {sub anti} {sub b,0}{sup {sub +}{sub +)}} = 18.84 ± 0.09 GeV and M{sub X(bb} {sub anti} {sub b} {sub anti} {sub b,2}{sup {sub +}{sub +)}} = 18.85 ± 0.09 GeV, which can be confronted to the experimental data in the future. Furthermore, we illustrate that the diquark-antidiquark type tetraquark state can be taken as a special superposition of a series of meson-meson pairs and that it embodies the net effects. (orig.)

  9. Coordinates of the quantum plane as q-tensor operators in Uq (su(2) * su(2))

    International Nuclear Information System (INIS)

    Biedenharn, L.C.; Lohe, M.A.

    1995-01-01

    The relation between the set of transformations M q (2) of the quantum plane and the quantum universal enveloping algebra U q (u(2)) is investigated by constructing representations of the factor algebra U q (u(2) * u(2)). The non-commuting coordinates of M q (2), on which U q (2) * U q (2) acts, are realized as q-spinors with respect to each U q (u(2)) algebra. The representation matrices of U q (2) are constructed as polynomials in these spinor components. This construction allows a derivation of the commutation relations of the noncommuting coordinates of M q (2) directly from properties of U q (u(2)). The generalization of these results to U q (u(n)) and M q (n) is also discussed

  10. Quality of service regulation, q follows x

    International Nuclear Information System (INIS)

    Meijer, A.Th.

    2005-01-01

    Both the Electricity Act and Gas Act have been recently amended. One of many changes made, was the addition of a system of 'quality of service regulation' to the existing system of price cap regulation. In this article the author explores the system of quality of service regulation in the Electricity Act. Quality of service regulation aims to counterbalance the possible adverse effects of price cap regulation.The Dutch transmission and distribution systems have always been very reliable, especially compared to those in other countries. Nevertheless, the average duration of interruptions to supply per year has risen slightly in recent years. In order to ensure that price reductions will not lead to a further decrease in the quality of service the Dutch legislator has decided to incorporate the aspect of reliability into the existing system of price cap regulation. Both the Electricity Act and Gas Act provide for a system of yardstick competition, whereby good quality of service is financially rewarded and poor quality of service will lead to additional price reductions.This was achieved by incorporating a quality parameter (an extra variable) in the existing price cap formula. Also, all Distribution Network Operators (DNOs) are required to adopt a quality management system. Every other year DNOs must draw up a 'quality and capacity document' which they must publicise. In this document DNOs wilt have to demonstrate that their quality management systems are adequate. Various aspects of the system of quality of service regulation are detailed in Iower legislation by the Minister of Economic Affairs and in several decisions by the Director of DTe. In a decision of 8 October 2005 the Director of DTe adopted the method by which the quality parameter (or 'q factor') with respect to the second price control period (2004-2006) is to be determined.This decision is also referred to as the 'methode-besluit'. Distribution Network Operators (DNOs) can be penalised or rewarded by

  11. Theoretical Significance in Q Methodology: A Qualitative Approach to a Mixed Method

    Science.gov (United States)

    Ramlo, Susan

    2015-01-01

    Q methodology (Q) has offered researchers a unique scientific measure of subjectivity since William Stephenson's first article in 1935. Q's focus on subjectivity includes self-referential meaning and interpretation. Q is most often identified with its technique (Q-sort) and its method (factor analysis to group people); yet, it consists of a…

  12. Complex Phenotype Associated with 17q21.31 Microdeletion

    Science.gov (United States)

    Dornelles-Wawruk, H.; Pic-Taylor, A.; Rosenberg, C.; Krepischi, A.C.V.; Safatle, H.P.N.; Ferrari, I.; Mazzeu, J.F.

    2013-01-01

    We report on a patient carrying a 17q21.31 microdeletion and exhibiting many common syndrome features, together with other clinical signs which have rarely or never been described to date. The detected 695-kb 17q21.31 deletion is larger than in most previously reported cases but is still probably the result of recombination between flanking low-copy repeats. Due to the complexity of the patient's clinical condition, together with the presence of 3 previously unreported symptoms, namely chronic anemia, cervical vertebrae arthrosis and vertebrae fusion, this case is an important addition to the existing knowledge about the 17q21.31 microdeletion syndrome. PMID:24167466

  13. Recurrent duplications of 17q12 associated with variable phenotypes

    DEFF Research Database (Denmark)

    Mitchell, Elyse; Douglas, Andrew; Kjaegaard, Susanne

    2015-01-01

    The ability to identify the clinical nature of the recurrent duplication of chromosome 17q12 has been limited by its rarity and the diverse range of phenotypes associated with this genomic change. In order to further define the clinical features of affected patients, detailed clinical information......, potentially contributory copy number changes in a subset of patients, including one patient each with 16p11.2 deletion and 15q13.3 deletion. Our data further define and expand the clinical spectrum associated with duplications of 17q12 and provide support for the role of genomic modifiers contributing...... to phenotypic variability....

  14. High Q-factor tunable superconducting HF circuit

    CERN Document Server

    Vopilkin, E A; Pavlov, S A; Ponomarev, L I; Ganitsev, A Y; Zhukov, A S; Vladimirov, V V; Letyago, A G; Parshikov, V V

    2001-01-01

    Feasibility of constructing a high Q-factor (Q approx 10 sup 5) mechanically tunable in a wide range of frequencies (12-63 MHz) vibration circuit of HF range was considered. The tunable circuit integrates two single circuits made using YBaCuO films. The circuit frequency is tuned by changing distance X (capacity) between substrates. Potentiality of using substrates of lanthanum aluminate, neodymium gallate and strontium titanate for manufacture of single circuits was considered. Q-factor of the circuit amounted to 68000 at resonance frequency of 6.88 MHz

  15. High Q-factor tunable superconducting HF circuit

    International Nuclear Information System (INIS)

    Vopilkin, E.A.; Parafin, A.E.; Pavlov, S.A.; Ponomarev, L.I.; Ganitsev, A.Yu.; Zhukov, A.S.; Vladimirov, V.V.; Letyago, A.G.; Parshikov, V.V.

    2001-01-01

    Feasibility of constructing a high Q-factor (Q ∼ 10 5 ) mechanically tunable in a wide range of frequencies (12-63 MHz) vibration circuit of HF range was considered. The tunable circuit integrates two single circuits made using YBaCuO films. The circuit frequency is tuned by changing distance X (capacity) between substrates. Potentiality of using substrates of lanthanum aluminate, neodymium gallate and strontium titanate for manufacture of single circuits was considered. Q-factor of the circuit amounted to 68000 at resonance frequency of 6.88 MHz [ru

  16. [p,q] {ne} i{Dirac_h}

    Energy Technology Data Exchange (ETDEWEB)

    Costella, J P

    1995-05-22

    In this short note, it is argued that [p, q] {ne} i{Dirac_h}, contrary to the oiginal claims of Born and Jordan, and Dirac. Rather, [p, q] is equal to something that is infinitesimally different from i{Dirac_h}. While this difference is usually harmless, it does provide the solution of the Born-Jordan `trace paradox` of [p, q]. More recently, subtleties of a very similar form have been found to be of fundamental importance in quantum field theory. 3 refs.

  17. Validation of endogenous reference genes for qRT-PCR analysis of human visceral adipose samples.

    Science.gov (United States)

    Mehta, Rohini; Birerdinc, Aybike; Hossain, Noreen; Afendy, Arian; Chandhoke, Vikas; Younossi, Zobair; Baranova, Ancha

    2010-05-21

    Given the epidemic proportions of obesity worldwide and the concurrent prevalence of metabolic syndrome, there is an urgent need for better understanding the underlying mechanisms of metabolic syndrome, in particular, the gene expression differences which may participate in obesity, insulin resistance and the associated series of chronic liver conditions. Real-time PCR (qRT-PCR) is the standard method for studying changes in relative gene expression in different tissues and experimental conditions. However, variations in amount of starting material, enzymatic efficiency and presence of inhibitors can lead to quantification errors. Hence the need for accurate data normalization is vital. Among several known strategies for data normalization, the use of reference genes as an internal control is the most common approach. Recent studies have shown that both obesity and presence of insulin resistance influence an expression of commonly used reference genes in omental fat. In this study we validated candidate reference genes suitable for qRT-PCR profiling experiments using visceral adipose samples from obese and lean individuals. Cross-validation of expression stability of eight selected reference genes using three popular algorithms, GeNorm, NormFinder and BestKeeper found ACTB and RPII as most stable reference genes. We recommend ACTB and RPII as stable reference genes most suitable for gene expression studies of human visceral adipose tissue. The use of these genes as a reference pair may further enhance the robustness of qRT-PCR in this model system.

  18. Validation of endogenous reference genes for qRT-PCR analysis of human visceral adipose samples

    Directory of Open Access Journals (Sweden)

    Afendy Arian

    2010-05-01

    Full Text Available Abstract Background Given the epidemic proportions of obesity worldwide and the concurrent prevalence of metabolic syndrome, there is an urgent need for better understanding the underlying mechanisms of metabolic syndrome, in particular, the gene expression differences which may participate in obesity, insulin resistance and the associated series of chronic liver conditions. Real-time PCR (qRT-PCR is the standard method for studying changes in relative gene expression in different tissues and experimental conditions. However, variations in amount of starting material, enzymatic efficiency and presence of inhibitors can lead to quantification errors. Hence the need for accurate data normalization is vital. Among several known strategies for data normalization, the use of reference genes as an internal control is the most common approach. Recent studies have shown that both obesity and presence of insulin resistance influence an expression of commonly used reference genes in omental fat. In this study we validated candidate reference genes suitable for qRT-PCR profiling experiments using visceral adipose samples from obese and lean individuals. Results Cross-validation of expression stability of eight selected reference genes using three popular algorithms, GeNorm, NormFinder and BestKeeper found ACTB and RPII as most stable reference genes. Conclusions We recommend ACTB and RPII as stable reference genes most suitable for gene expression studies of human visceral adipose tissue. The use of these genes as a reference pair may further enhance the robustness of qRT-PCR in this model system.

  19. A New Finite Difference Q-compensated RTM Algorithm in Tilted Transverse Isotropic (TTI) Media

    Science.gov (United States)

    Zhou, T.; Hu, W.; Ning, J.

    2017-12-01

    Attenuating anisotropic geological body is difficult to image with conventional migration methods. In such kind of scenarios, recorded seismic data suffer greatly from both amplitude decay and phase distortion, resulting in degraded resolution, poor illumination and incorrect migration depth in imaging results. To efficiently obtain high quality images, we propose a novel TTI QRTM algorithm based on Generalized Standard Linear Solid model combined with a unique multi-stage optimization technique to simultaneously correct the decayed amplitude and the distorted phase velocity. Numerical tests (shown in the figure) demonstrate that our TTI QRTM algorithm effectively corrects migration depth, significantly improves illumination, and enhances resolution within and below the low Q regions. The result of our new method is very close to the reference RTM image, while QRTM without TTI cannot get a correct image. Compared to the conventional QRTM method based on a pseudo-spectral operator for fractional Laplacian evaluation, our method is more computationally efficient for large scale applications and more suitable for GPU acceleration. With the current multi-stage dispersion optimization scheme, this TTI QRTM method best performs in the frequency range 10-70 Hz, and could be used in a wider frequency range. Furthermore, as this method can also handle frequency dependent Q, it has potential to be applied in imaging deep structures where low Q exists, such as subduction zones, volcanic zones or fault zones with passive source observations.

  20. A novel 3q29 deletion associated with autism, intellectual disability, psychiatric disorders, and obesity.

    Science.gov (United States)

    Biamino, Elisa; Di Gregorio, Eleonora; Belligni, Elga Fabia; Keller, Roberto; Riberi, Evelise; Gandione, Marina; Calcia, Alessandro; Mancini, Cecilia; Giorgio, Elisa; Cavalieri, Simona; Pappi, Patrizia; Talarico, Flavia; Fea, Antonio M; De Rubeis, Silvia; Cirillo Silengo, Margherita; Ferrero, Giovanni Battista; Brusco, Alfredo

    2016-03-01

    Copy number variation (CNV) has been associated with a variety of neuropsychiatric disorders, including intellectual disability/developmental delay (ID/DD), autism spectrum disorder (ASD), and schizophrenia (SCZ). Often, individuals carrying the same pathogenic CNV display high clinical variability. By array-CGH analysis, we identified a novel familial 3q29 deletion (1.36 Mb), centromeric to the 3q29 deletion region, which manifests with variable expressivity. The deletion was identified in a 3-year-old girl diagnosed with ID/DD and autism and segregated in six family members, all affected by severe psychiatric disorders including schizophrenia, major depression, anxiety disorder, and personality disorder. All individuals carrying the deletion were overweight or obese, and anomalies compatible with optic atrophy were observed in three out of four cases examined. Amongst the 10 genes encompassed by the deletion, the haploinsufficiency of Optic Atrophy 1 (OPA1), associated with autosomal dominant optic atrophy, is likely responsible for the ophthalmological anomalies. We hypothesize that the haploinsufficiency of ATPase type 13A4 (ATP13A4) and/or Hairy/Enhancer of Split Drosophila homolog 1 (HES1) contribute to the neuropsychiatric phenotype, while HES1 deletion might underlie the overweight/obesity. In conclusion, we propose a novel contiguous gene syndrome due to a proximal 3q29 deletion variably associated with autism, ID/DD, psychiatric traits and overweight/obesity. © 2015 Wiley Periodicals, Inc.

  1. q-deformations of noncompact Lie (super-) algebras: The examples of q-deformed Lorentz, Weyl, Poincare' and (super-) conformal algebras

    International Nuclear Information System (INIS)

    Dobrev, V.K.

    1992-01-01

    We review and explain a canonical procedure for the q-deformation of the real forms G of complex Lie (super-) algebras associated with (generalized) Cartan matrices. Our procedure gives different q-deformations for the non-conjugate Cartan subalgebras of G. We give several in detail the q-deformed Lorentz and conformal (super-) algebras. The q-deformed conformal algebra contains as a subalgebra a q-deformed Poincare algebra and as Hopf subalgebras two conjugate 11-generator q-deformed Weyl algebras. The q-deformed Lorentz algebra in Hopf subalgebra of both Weyl algebras. (author). 24 refs

  2. On the Hopf structure of Up,q(gl(1/1)) and the universal Τ-matrix of Funp,q(GL(1/1))

    International Nuclear Information System (INIS)

    Chakrabarti, R.; Jagannathan, R.

    1994-08-01

    Using the technique developed by Fronsdal and Galindo (Lett. Math. Phys, 27 (1993) 57) for studying the Hopf duality between the quantum algebras Fun p,q (GL(2)) and U p,q (gl(2)), the Hopf structure of U p,q (gl(1/1)), dual to Fun p,q (GL(1/1)), is derived and the corresponding universal Τ-matrix of Fun p,q (GL(1/1)), embodying the suitably modified exponential relationship U p,q (gl(1/1)) → Fun p,q (GL(1/1)), is obtained. (author). 10 refs

  3. Topical treatment with coenzyme Q10-containing formulas improves skin's Q10 level and provides antioxidative effects.

    Science.gov (United States)

    Knott, Anja; Achterberg, Volker; Smuda, Christoph; Mielke, Heiko; Sperling, Gabi; Dunckelmann, Katja; Vogelsang, Alexandra; Krüger, Andrea; Schwengler, Helge; Behtash, Mojgan; Kristof, Sonja; Diekmann, Heike; Eisenberg, Tanya; Berroth, Andreas; Hildebrand, Janosch; Siegner, Ralf; Winnefeld, Marc; Teuber, Frank; Fey, Sven; Möbius, Janne; Retzer, Dana; Burkhardt, Thorsten; Lüttke, Juliane; Blatt, Thomas

    2015-01-01

    Ubiquinone (coenzyme Q10, Q10) represents an endogenously synthesized lipid-soluble antioxidant which is crucial for cellular energy production but is diminished with age and under the influence of external stress factors in human skin. Here, it is shown that topical Q10 treatment is beneficial with regard to effective Q10 replenishment, augmentation of cellular energy metabolism, and antioxidant effects. Application of Q10-containing formulas significantly increased the levels of this quinone on the skin surface. In the deeper layers of the epidermis the ubiquinone level was significantly augmented indicating effective supplementation. Concurrent elevation of ubiquinol levels suggested metabolic transformation of ubiquinone resulting from increased energy metabolism. Incubation of cultured human keratinocytes with Q10 concentrations equivalent to treated skin showed a significant augmentation of energy metabolism. Moreover, the results demonstrated that stressed skin benefits from the topical Q10 treatment by reduction of free radicals and an increase in antioxidant capacity. © 2015 International Union of Biochemistry and Molecular Biology.

  4. Prenatal diagnosis and molecular cytogenetic characterization of a derivative chromosome der(18;18(q10;q10del(18(q11.1q12.1del(18(q22.1q22.3 presenting as apparent isochromosome 18q in a fetus with holoprosencephaly

    Directory of Open Access Journals (Sweden)

    Chih-Ping Chen

    2011-06-01

    Conclusion: Concomitant monosomy 18p and trisomy 18q can be associated with holoprosencephaly and abnormal maternal serum screening results. Array-comparative genomic hybridization, fluorescence in situ hybridization, and quantitative fluorescent polymerase chain reaction are useful in genetic counseling of prenatally detected isochromosomes by providing information on the origin and genetic components of the isochromosome.

  5. Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders

    Science.gov (United States)

    Isles, Anthony R.; Ingason, Andrés; Lowther, Chelsea; Gawlick, Micha; Stöber, Gerald; Potter, Harry; Georgieva, Lyudmila; Pizzo, Lucilla; Ozaki, Norio; Kushima, Itaru; Ikeda, Masashi; Iwata, Nakao; Levinson, Douglas F.; Gejman, Pablo V.; Shi, Jianxin; Sanders, Alan R.; Duan, Jubao; Sisodiya, Sanjay; Costain, Gregory; Degenhardt, Franziska; Giegling, Ina; Rujescu, Dan; Hreidarsson, Stefan J.; Saemundsen, Evald; Ahn, Joo Wook; Ogilvie, Caroline; Stefansson, Hreinn; Stefansson, Kari; O’Donovan, Michael C.; Owen, Michael J.; Bassett, Anne; Kirov, George

    2016-01-01

    Duplications at 15q11.2-q13.3 overlapping the Prader-Willi/Angelman syndrome (PWS/AS) region have been associated with developmental delay (DD), autism spectrum disorder (ASD) and schizophrenia (SZ). Due to presence of imprinted genes within the region, the parental origin of these duplications may be key to the pathogenicity. Duplications of maternal origin are associated with disease, whereas the pathogenicity of paternal ones is unclear. To clarify the role of maternal and paternal duplications, we conducted the largest and most detailed study to date of parental origin of 15q11.2-q13.3 interstitial duplications in DD, ASD and SZ cohorts. We show, for the first time, that paternal duplications lead to an increased risk of developing DD/ASD/multiple congenital anomalies (MCA), but do not appear to increase risk for SZ. The importance of the epigenetic status of 15q11.2-q13.3 duplications was further underlined by analysis of a number of families, in which the duplication was paternally derived in the mother, who was unaffected, whereas her offspring, who inherited a maternally derived duplication, suffered from psychotic illness. Interestingly, the most consistent clinical characteristics of SZ patients with 15q11.2-q13.3 duplications were learning or developmental problems, found in 76% of carriers. Despite their lower pathogenicity, paternal duplications are less frequent in the general population with a general population prevalence of 0.0033% compared to 0.0069% for maternal duplications. This may be due to lower fecundity of male carriers and differential survival of embryos, something echoed in the findings that both types of duplications are de novo in just over 50% of cases. Isodicentric chromosome 15 (idic15) or interstitial triplications were not observed in SZ patients or in controls. Overall, this study refines the distinct roles of maternal and paternal interstitial duplications at 15q11.2-q13.3, underlining the critical importance of maternally

  6. Parental Origin of Interstitial Duplications at 15q11.2-q13.3 in Schizophrenia and Neurodevelopmental Disorders.

    Directory of Open Access Journals (Sweden)

    Anthony R Isles

    2016-05-01

    Full Text Available Duplications at 15q11.2-q13.3 overlapping the Prader-Willi/Angelman syndrome (PWS/AS region have been associated with developmental delay (DD, autism spectrum disorder (ASD and schizophrenia (SZ. Due to presence of imprinted genes within the region, the parental origin of these duplications may be key to the pathogenicity. Duplications of maternal origin are associated with disease, whereas the pathogenicity of paternal ones is unclear. To clarify the role of maternal and paternal duplications, we conducted the largest and most detailed study to date of parental origin of 15q11.2-q13.3 interstitial duplications in DD, ASD and SZ cohorts. We show, for the first time, that paternal duplications lead to an increased risk of developing DD/ASD/multiple congenital anomalies (MCA, but do not appear to increase risk for SZ. The importance of the epigenetic status of 15q11.2-q13.3 duplications was further underlined by analysis of a number of families, in which the duplication was paternally derived in the mother, who was unaffected, whereas her offspring, who inherited a maternally derived duplication, suffered from psychotic illness. Interestingly, the most consistent clinical characteristics of SZ patients with 15q11.2-q13.3 duplications were learning or developmental problems, found in 76% of carriers. Despite their lower pathogenicity, paternal duplications are less frequent in the general population with a general population prevalence of 0.0033% compared to 0.0069% for maternal duplications. This may be due to lower fecundity of male carriers and differential survival of embryos, something echoed in the findings that both types of duplications are de novo in just over 50% of cases. Isodicentric chromosome 15 (idic15 or interstitial triplications were not observed in SZ patients or in controls. Overall, this study refines the distinct roles of maternal and paternal interstitial duplications at 15q11.2-q13.3, underlining the critical importance of

  7. A first case of primary amenorrhea with i(X(qter---q10::---qter, rob(13;14(q10;q10, inv(9(p13q33 karyotype

    Directory of Open Access Journals (Sweden)

    Seema Korgaonkar

    2011-01-01

    Full Text Available Primary amenorrhea (PA refers to the absence of menarche by the age of 16-18 years although secondary sexual characters are developed. PA occurs in 1-3% of women in the reproductive age group. Various factors such as anatomical, genetic and hormonal factors reported to influence PA. We report triple chromosomal abnormalities of rob(13;14(q10;q10,inv(9(p13q33, i(Xq(qter---q10::---qter in a case of PA and short stature. Though proband has multiple chromosome aberrations, genotypic effect of only i(Xq is evident as proband has PA and short stature. The rob(13;14 and inv(9, which are paternally derived may have role in later reproductive age. Therefore, chromosomal analysis is essential in such cases for the accurate diagnosis and management of the disease.

  8. On the maximum Q in feedback controlled subignited plasmas

    International Nuclear Information System (INIS)

    Anderson, D.; Hamnen, H.; Lisak, M.

    1990-01-01

    High Q operation in feedback controlled subignited fusion plasma requires the operating temperature to be close to the ignition temperature. In the present work we discuss technological and physical effects which may restrict this temperature difference. The investigation is based on a simplified, but still accurate, 0=D analytical analysis of the maximum Q of a subignited system. Particular emphasis is given to sawtooth ocsillations which complicate the interpretation of diagnostic neutron emission data into plasma temperatures and may imply an inherent lower bound on the temperature deviation from the ignition point. The estimated maximum Q is found to be marginal (Q = 10-20) from the point of view of a fusion reactor. (authors)

  9. An upper bound on Q-star masses

    International Nuclear Information System (INIS)

    Hochron, D.R.; Selipsky, S.B.

    1992-06-01

    Q-stars (the gravitational generalization of Q-balls, strongly bound bulk matter that an appear in field theories of strongly interacting hadrons) are the only known impact objects consistent with the known bulk structure of nuclei and chiral symmetry that evade the Rhoades-Ruffini upper bound of 3.2M circle-dot . Generic bounds are quite weak: M Q-star circle-dot . If, however, we assume that the 1.558 ms pulsar is a Q-star, equilibrium. A stability criteria of rotating fluids place a much stronger upper bound of M c ≤ 5.3M circle-dot on such models under certain special assumptions. This has important implications for heavy compact objects such as Cygnus X-1

  10. Hepatoprotective effect of taurine and coenzyme Q10 and their ...

    African Journals Online (AJOL)

    stress in rats. Afaf Abbass Sayed ... Keywords: Taurine, Coenzyme Q10, Acrylamide, Oxidative stress, Biochemical profile, ... uses, AA formation in foods has its major routes through .... release of serum inflammatory markers and neutrophil ...

  11. Missionary Ethics in Q 10:2−12

    Directory of Open Access Journals (Sweden)

    Dieter T. Roth

    2012-06-01

    Full Text Available Elements of the mission discourse of the Synoptic Gospels are found in Mark 6:6b−13; Matthew 9:35−10:15; Luke 9:1−6 and Luke 10:1−20. Similarities and differences in these accounts have led many New Testament scholars to posit the presence of a mission discourse in Q. This discourse, along with the parable that introduces it (Q 10:2, provides insight into how Q conceives of ‘mission’ as well as the ethical principles and precepts that are part of Jesus’ missional charge in this document. Through an intertextual approach to Q, with particular emphasis on narrative structure and imagery, this paper considered the interplay of mission and ethics in this early Christian text.

  12. Spectral inverse problem for q-deformed harmonic oscillator

    Indian Academy of Sciences (India)

    - out direct ... concepts, exact knowledge of the spectrum is not enough for the reconstruction of ..... As the superpotential is related to the ground-state wave function, we demand ..... q-hypergeometric function multiplied by some weight factor.

  13. Study of the AC machines winding having fractional q

    Science.gov (United States)

    Bespalov, V. Y.; Sidorov, A. O.

    2018-02-01

    The winding schemes with a fractional numbers of slots per pole and phase q have been known and used for a long time. However, in the literature on the low-noise machines design there are not recommended to use. Nevertheless, fractional q windings have been realized in many applications of special AC electrical machines, allowing to improve their performance, including vibroacoustic one. This paper deals with harmonic analysis of windings having integer and fractional q in permanent magnet synchronous motors, a comparison of their characteristics is performed, frequencies of subharmonics are revealed. Optimal winding pitch design is found giving reduce the amplitudes of subharmonics. Distribution factors for subharmonics, fractional and high-order harmonics are calculated, results analysis is represented, allowing for giving recommendations how to calculate distribution factors for different harmonics when q is fractional.

  14. P-Q simultaneous control scheme for SMES

    International Nuclear Information System (INIS)

    Tsuji, K.; Ise, T.; Murakami, Y.

    1981-01-01

    Superconducting magnetic energy storage (SMES) can be looked at as a control device as well as an effective energy storage device in power system applications. Thus far, active power control and reactive power control seem to have been treated separately. However, under some minor constraints, active (P) and reactive power (Q) may be controlled simultaneously and this capability is perhaps one of the most valuable characteristics of SMES in power system applications. In this brief paper, we examine the possibility of controlling active and reactive power simultaneously (henceforth we call it P-Q simultaneous control) and propose a direct digital control algorithm for the P-Q simultaneous control of SMES. Some simulation results are presented. In addition, a hierarchical control scheme for SMES at a load center is briefly discussed as an extension of P-Q simultaneous control presented in this paper

  15. Unconditionally convergent series in the space C(Q)

    International Nuclear Information System (INIS)

    Basit, B.

    1981-08-01

    Let B be a Banach space and B* its dual Banach space. B contains csub(0) (B does not contain csub(0)) if B contains (does not contain) a subspace isomorphic to the space csub(0) of sequences of numbers tending to zero. The series Σsub(n=1)sup(infinity) xsub(n) of elements of B is weakly unconditionally convergent (w.u.c.) iff Σsub(n=1)sup(infinity)|x*(xsub(n))| 0 . Series of elements of C(Q) are considered here. Subspaces of C(Q) isomorphic to c 0 are constructed, and criteria for a series of elements of C(Q) to be w.u.c. or u.c. are given. Finally, an improved theorem of giving characterizations of the elements of subalgebras of C(Q) not containing c 0 is presented

  16. High mechanical Q-factor measurements on silicon bulk material

    Energy Technology Data Exchange (ETDEWEB)

    Schwarz, Christian; Nawrodt, Ronny; Heinert, Daniel; Schroeter, Anja; Neubert, Ralf; Thuerk, Matthias; Vodel, Wolfgang; Seidel, Paul [Institut fuer Festkoerperphysik, Helmholtzweg 5, D-07743 Jena (Germany); Tuennermann, Andreas [Institut fuer Angewandte Physik, Albert-Einstein-Strasse 15, D-07745 Jena (Germany)

    2008-07-01

    The direct observation of gravitational waves is one of the biggest challenges in science. Current detectors are limited by different kinds of noise. One of the fundamental noise sources is thermal noise arising from the optical components. One of the most promising attempts to reduce the thermal noise contribution in future detectors will be the use of high Q-factor materials at cryogenic temperatures. Silicon seems to be the most interesting material due to its excellent optical and thermal properties. We present high Q-factor measurements on bulk samples of high purity silicon in a temperature range from 5 to 300 K. The sample dimensions vary between 76.2 mm x 12..75 mm. The Q-factor exceeds 4.10{sup 8} at 6 K. The influence of the crystal orientation, doping and the sample preparation on the Q-factor is discussed.

  17. Dostojevskilik kapseldunud elu Q-teatris / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres

    1997-01-01

    Fjodor Dostojevski jutustuse 'Ülestähendusi põranda alt' järgi tehtud Soome Q-teatri lavastusest 'Kelder' ("Kellari", dramatiseerinud Antti Hietala, Hannu Kivioja ja Erik Söderblom, lav. Erik Söderblom)

  18. Lower bounds on Q of some dipole shapes

    DEFF Research Database (Denmark)

    Kim, Oleksiy S.

    2016-01-01

    The lower bound on the radiation Q of an arbitrary electrically small antenna shape can be determined by finding the optimal electric current density on the exterior surface of the shape, such that the Q of this current radiating in free space is minimized, and then augmenting it with a magnetic...... current density cancelling the fields inside the shape's surface. The Q of these coupled electric and magnetic currents radiating in free space is the lower bound on Q for the given shape. The approach is exemplified and its general applicability is substantiated by computing the lower bounds...... of spherically capped dipoles and comparing the results to the known bounds of a sphere and a thin cylinder....

  19. Analytic derivation of the leading-order gluon distribution function G(x,Q2)=xg(x,Q2) from the proton structure function F2p(x,Q2)

    International Nuclear Information System (INIS)

    Block, Martin M.; Durand, Loyal; McKay, Douglas W.

    2008-01-01

    We derive a second-order linear differential equation for the leading-order gluon distribution function G(x,Q 2 )=xg(x,Q 2 ) which determines G(x,Q 2 ) directly from the proton structure function F 2 p (x,Q 2 ). This equation is derived from the leading-order evolution equation for F 2 p (x,Q 2 ), and does not require knowledge of either the individual quark distributions or the gluon evolution equation. Given an analytic expression that successfully reproduces the known experimental data for F 2 p (x,Q 2 ) in a domain x min (Q 2 )≤x≤x max (Q 2 ), Q min 2 ≤Q 2 ≤Q max 2 of the Bjorken variable x and the virtuality Q 2 in deep inelastic scattering, G(x,Q 2 ) is uniquely determined in the same domain. We give the general solution and illustrate the method using the recently proposed Froissart-bound-type parametrization of F 2 p (x,Q 2 ) of E. L. Berger, M. M. Block and C.-I. Tan [Phys. Rev. Lett. 98, 242001 (2007)]. Existing leading-order gluon distributions based on power-law descriptions of individual parton distributions agree roughly with the new distributions for x > or approx. 10 -3 as they should, but are much larger for x -3 .

  20. Wave-equation Q tomography and least-squares migration

    KAUST Repository

    Dutta, Gaurav

    2016-03-01

    This thesis designs new methods for Q tomography and Q-compensated prestack depth migration when the recorded seismic data suffer from strong attenuation. A motivation of this work is that the presence of gas clouds or mud channels in overburden structures leads to the distortion of amplitudes and phases in seismic waves propagating inside the earth. If the attenuation parameter Q is very strong, i.e., Q<30, ignoring the anelastic effects in imaging can lead to dimming of migration amplitudes and loss of resolution. This, in turn, adversely affects the ability to accurately predict reservoir properties below such layers. To mitigate this problem, I first develop an anelastic least-squares reverse time migration (Q-LSRTM) technique. I reformulate the conventional acoustic least-squares migration problem as a viscoacoustic linearized inversion problem. Using linearized viscoacoustic modeling and adjoint operators during the least-squares iterations, I show with numerical tests that Q-LSRTM can compensate for the amplitude loss and produce images with better balanced amplitudes than conventional migration. To estimate the background Q model that can be used for any Q-compensating migration algorithm, I then develop a wave-equation based optimization method that inverts for the subsurface Q distribution by minimizing a skeletonized misfit function ε. Here, ε is the sum of the squared differences between the observed and the predicted peak/centroid-frequency shifts of the early-arrivals. Through numerical tests on synthetic and field data, I show that noticeable improvements in the migration image quality can be obtained from Q models inverted using wave-equation Q tomography. A key feature of skeletonized inversion is that it is much less likely to get stuck in a local minimum than a standard waveform inversion method. Finally, I develop a preconditioning technique for least-squares migration using a directional Gabor-based preconditioning approach for isotropic

  1. A Q fever case mimicking crimean-congo haemorrhagic fever

    Directory of Open Access Journals (Sweden)

    O Karabay

    2011-01-01

    Full Text Available Coxiella burnetii is the bacterium that causes Q fever. Human infection is mainly transmitted from cattle, goats and sheep. The disease is usually self-limited. Pneumonia and hepatitis are the most common clinical manifestations. In this study, we present a case of Q fever from the western part of Turkey mimicking Crimean-Congo haemorrhagic fever (CCHF in terms of clinical and laboratory findings.

  2. Dunkl Generalization of q-Parametric Szasz-Mirakjan Operators

    Directory of Open Access Journals (Sweden)

    M. Mursaleen

    2017-03-01

    Full Text Available In this paper, we construct q-parametric Szász-Mirakjan operators generated by the q-Dunkl generalization of the exponential function. We obtain Korovkin’s type approximation theorem and compute convergence of these operators by using the modulus of continuity. Furthermore, we obtain the rate of convergence of these operators for functions belonging to the Lipschitz class.

  3. Clival encephalocele and 5q15 deletion: a case report.

    Science.gov (United States)

    Puvabanditsin, Surasak; Malik, Imran; Garrow, Eugene; Francois, Lissa; Mehta, Rajeev

    2015-03-01

    A preterm neonate presenting with respiratory distress after birth was found to have a clival encephalocele, which is a variant of a basal encephalocele, and hypoplasia of the cerebellum. Genetic studies revealed a small deletion of the long arm of chromosome 5: 5q15 deletion. We report a rare variant of a basal encephalocele with a cerebellar malformation and 5q15 deletion. © The Author(s) 2014.

  4. On q-deformed supersymmetric classical mechanical models

    International Nuclear Information System (INIS)

    Colatto, L.P.; Matheus Valle, J.L.

    1995-10-01

    Based on the idea of quantum groups and paragrassmann variables, we present a generalization of supersymmetric classical mechanics with a deformation parameter q=exp 2πi/k dealing with the k=3 case. The coordinates of the q-superspace are a commuting parameter t and a paragrassmann variable θ, where θ 3 =0. The generator and covariant derivative are obtained, as well as the action for some possible superfields. (author). 13 refs

  5. On sums of q-independent SUq(2) quantum variables

    International Nuclear Information System (INIS)

    Lenczewski, R.

    1993-01-01

    A representation-free approach to the q-analog of the quantum central limit theorem for C=SU 1 (2) is presented. It is shown that for certain functions φε-C* one can derive a version of a quantum central limit theorem (qclt) with √[N] as a scaling parameter, which may be viewed as a q-analog of qclt. (orig.)

  6. R248Q mutation--Beyond p53-DNA binding.

    Science.gov (United States)

    Ng, Jeremy W K; Lama, Dilraj; Lukman, Suryani; Lane, David P; Verma, Chandra S; Sim, Adelene Y L

    2015-12-01

    R248 in the DNA binding domain (DBD) of p53 interacts directly with the minor groove of DNA. Earlier nuclear magnetic resonance (NMR) studies indicated that the R248Q mutation resulted in conformation changes in parts of DBD far from the mutation site. However, how information propagates from the mutation site to the rest of the DBD is still not well understood. We performed a series of all-atom molecular dynamics (MD) simulations to dissect sterics and charge effects of R248 on p53-DBD conformation: (i) wild-type p53 DBD; (ii) p53 DBD with an electrically neutral arginine side-chain; (iii) p53 DBD with R248A; (iv) p53 DBD with R248W; and (v) p53 DBD with R248Q. Our results agree well with experimental observations of global conformational changes induced by the R248Q mutation. Our simulations suggest that both charge- and sterics are important in the dynamics of the loop (L3) where the mutation resides. We show that helix 2 (H2) dynamics is altered as a result of a change in the hydrogen bonding partner of D281. In turn, neighboring L1 dynamics is altered: in mutants, L1 predominantly adopts the recessed conformation and is unable to interact with the major groove of DNA. We focused our attention the R248Q mutant that is commonly found in a wide range of cancer and observed changes at the zinc-binding pocket that might account for the dominant negative effects of R248Q. Furthermore, in our simulations, the S6/S7 turn was more frequently solvent exposed in R248Q, suggesting that there is a greater tendency of R248Q to partially unfold and possibly lead to an increased aggregation propensity. Finally, based on the observations made in our simulations, we propose strategies for the rescue of R248Q mutants. © 2015 Wiley Periodicals, Inc.

  7. Fatigue following Acute Q-Fever: A Systematic Literature Review

    Science.gov (United States)

    Delsing, Corine E.; Bleijenberg, Gijs; Langendam, Miranda; Timen, Aura; Bleeker-Rovers, Chantal P.

    2016-01-01

    Background Long-term fatigue with detrimental effects on daily functioning often occurs following acute Q-fever. Following the 2007–2010 Q-fever outbreak in the Netherlands with over 4000 notified cases, the emphasis on long-term consequences of Q-fever increased. The aim of this study was to provide an overview of all relevant available literature, and to identify knowledge gaps regarding the definition, diagnosis, background, description, aetiology, prevention, therapy, and prognosis, of fatigue following acute Q-fever. Design A systematic review was conducted through searching Pubmed, Embase, and PsycInfo for relevant literature up to 26th May 2015. References of included articles were hand searched for additional documents, and included articles were quality assessed. Results Fifty-seven articles were included and four documents classified as grey literature. The quality of most studies was low. The studies suggest that although most patients recover from fatigue within 6–12 months after acute Q-fever, approximately 20% remain chronically fatigued. Several names are used indicating fatigue following acute Q-fever, of which Q-fever fatigue syndrome (QFS) is most customary. Although QFS is described to occur frequently in many countries, a uniform definition is lacking. The studies report major health and work-related consequences, and is frequently accompanied by nonspecific complaints. There is no consensus with regard to aetiology, prevention, treatment, and prognosis. Conclusions Long-term fatigue following acute Q-fever, generally referred to as QFS, has major health-related consequences. However, information on aetiology, prevention, treatment, and prognosis of QFS is underrepresented in the international literature. In order to facilitate comparison of findings, and as platform for future studies, a uniform definition and diagnostic work-up and uniform measurement tools for QFS are proposed. PMID:27223465

  8. Computation of the q -th roots of circulant matrices

    Directory of Open Access Journals (Sweden)

    Pakizeh Mohammadi Khanghah

    2014-05-01

    Full Text Available In this paper‎, ‎we investigate the reduced form of circulant matrices‎ ‎and we show that the problem of computing the $q$-th roots of a‎ ‎nonsingular circulant matrix $A$ can be reduced to that of computing‎ ‎the $q$-th roots of two half size matrices $B-C$ and $B+C$. 

  9. Nano(Q)SAR: Challenges, pitfalls and perspectives.

    Science.gov (United States)

    Tantra, Ratna; Oksel, Ceyda; Puzyn, Tomasz; Wang, Jian; Robinson, Kenneth N; Wang, Xue Z; Ma, Cai Y; Wilkins, Terry

    2015-01-01

    Regulation for nanomaterials is urgently needed, and the drive to adopt an intelligent testing strategy is evident. Such a strategy will not only provide economic benefits but will also reduce moral and ethical concerns arising from animal testing. For regulatory purposes, such an approach is promoted by REACH, particularly the use of quantitative structure-activity relationships [(Q)SAR] as a tool for the categorisation of compounds according to their physicochemical and toxicological properties. In addition to compounds, (Q)SAR has also been applied to nanomaterials in the form of nano(Q)SAR. Although (Q)SAR in chemicals is well established, nano(Q)SAR is still in early stages of development and its successful uptake is far from reality. This article aims to identify some of the pitfalls and challenges associated with nano-(Q)SARs in relation to the categorisation of nanomaterials. Our findings show clear gaps in the research framework that must be addressed if we are to have reliable predictions from such models. Three major barriers were identified: the need to improve quality of experimental data in which the models are developed from, the need to have practical guidelines for the development of the nano(Q)SAR models and the need to standardise and harmonise activities for the purpose of regulation. Of these three, the first, i.e. the need to improve data quality requires immediate attention, as it underpins activities associated with the latter two. It should be noted that the usefulness of data in the context of nano-(Q)SAR modelling is not only about the quantity of data but also about the quality, consistency and accessibility of those data.

  10. Passively synchronized dual-wavelength Q-switched lasers

    DEFF Research Database (Denmark)

    Janousek, Jiri; Tidemand-Lichtenberg, Peter; Mortensen, Jesper Liltorp

    We present a simple and efficient way of generating synchronized Q-switched pulses at wavelengths hundreds of nanometers apart. This principle can result in new pulsed all-solid-state light sources at new wavelengths based on SFG.......We present a simple and efficient way of generating synchronized Q-switched pulses at wavelengths hundreds of nanometers apart. This principle can result in new pulsed all-solid-state light sources at new wavelengths based on SFG....

  11. High-Q microwave photonic filter with a tuned modulator.

    Science.gov (United States)

    Capmany, J; Mora, J; Ortega, B; Pastor, D

    2005-09-01

    We propose the use of tuned electro-optic or electroabsorption external modulators to implement high-quality (high-Q) factor, single-bandpass photonic filters for microwave signals. Using this approach, we experimentally demonstrate a transversal finite impulse response with a Q factor of 237. This is to our knowledge the highest value ever reported for a passive finite impulse-response microwave photonic filter.

  12. The photon structure function at large Q2

    International Nuclear Information System (INIS)

    Cordier, A.

    1987-01-01

    LEP II offers the unique opportunity to measure the photon structure function over a large Q 2 range up to ∼ 2000 GeV 2 . Two crucial predictions of QCD can be tested in this experiment: the linear rise in log Q 2 as a consequence of asymptotic freedom, and the large renormalization O(1) of the shape of the structure function due to gluon bremsstrahlung, unperturbed by higher-twist effects

  13. Agnathia-holoprosencephaly associated with a 46,XY,-21,+t(21q;21q) karyotype

    Energy Technology Data Exchange (ETDEWEB)

    Niedermeyer, K.K.; McCorquodale, M.M.; Burton, B.K. [Univ. of Illinois, Chicago, IL (United States)

    1994-09-01

    We report an unusual case of agnathia-holoprosencephaly associated with Down syndrome due to a 21/21 translocation. The patient presented prenatally at 21 wks gestation. A fetal ultrasound revealed multiple CNS anomalies including hydrocephalus, compressed cerebellum, absent septum pellucidum and possible cranial meningocele or encephalocele. High resolution ultrasound & fetal karyotype were recommended. The patient refused & elected to have a pregnancy termination. Chromosomal analysis performed on products of conception revealed a 46,XY,-21,+t(21q;21q) karyotype. Fluorescence in situ hybridization was performed and confirmed the 21/21 translocation chromosome. An autopsy revealed agnathia and multiple CNS anomalies including absence of the septum pellucidum, absence of the corpus callosum, arhinencephaly, an occiptal meningoencephalocele, dilation of the lateral ventricles, and extensive dysgenesis & heterotopias of the central cerebrum & mid-brain. Additional abnormalities included a persistent left superior vena cava, atrial & ventricular septal defects, irregular length of the fingers with absence of the middle phalanges of the right 2nd and 5th & left 5th digits and bilateral simian creases. Agnathia can be an isolated abnormality but often is associated with holoprosencephaly and/or situs inversus. The majority of familial case of agnathis-holoprosencephaly was caused by an inherited unbalanced translocation resulting in duplication of 6p and monosomy of 18p. Our patient had a translocation form of trisomy 21 but did not have a phenotype consistent with Down syndrome. Trisomy 21 has not been previously reported in other cases of agnathia-holoprosencephaly. Whether the chromosomal abnormality caused the phenotypic abnormalities or if it is a coincidental finding cannot be determined.

  14. Q GSM tegi konkurentidele dünamo / Aivar Hundimägi

    Index Scriptorium Estoniae

    Hundimägi, Aivar, 1975-

    2004-01-01

    Mobiilsideoperaatorile Q GSM (praegune Tele2) edu taganud turundusstrateegiatest. Lisad: Q GSMi Dynamo teenuspaketi eesmärgid; Q GSMist sai Tele2. Diagramm: 2000. aastal turule toodud Dynamo pakett tõi murrangu

  15. Seroprevalence of Q fever in Goats in the Sudan

    Directory of Open Access Journals (Sweden)

    Diaeldin A Salih

    Full Text Available Aim: The survey was carried out to detect anti- C. burnetii antibodies in goat's sera samples in eight States in the Sudan during September 2010 – July 2011. Materials and Methods: In a preliminary study, four hundred and sixty caprine sera samples collected from eight States in the Sudan were screened for anti- Coxiella burnetii (the causative agent of Q fever antibodies using a commercial indirect ELISA (iELISA kit. Results: The results showed an overall prevalence rate 24.22% of Q fever antibodies. The prevalence rate of antibodies ranged from 6.7% in Kassala to 40% in South Darfur. The prevalence rates were highest in South Darfur (40% and South Kordofan (34.7%, moderate in El Gazira (29.7%, Khartoum (29.1%, the Northern (24% and the River Nile (20.2% States. It was lowest in the White Nile (7.5% and Kassala (6.7% States. Conclusion: It could be concluded that Q fever is prevalent in goats in the Sudan. Therefore, further epizootiological investigations on Q fever in other farm animals and man at the country level is important to monitor and determine the magnitude of Q fever infection in order to estimate its economic impact on animal industry and its public health hazard in the Sudan. In addition, the impact of Q fever among shepherds should be studied. [Vet. World 2012; 5(7.000: 394-397

  16. Hormonal Influence on Coenzyme Q10 Levels in Blood Plasma

    Directory of Open Access Journals (Sweden)

    Alfredo Pontecorvi

    2011-12-01

    Full Text Available Coenzyme Q10 (CoQ10, also known as ubiquinone for its presence in all body cells, is an essential part of the cell energy-producing system. However, it is also a powerful lipophilic antioxidant protecting lipoproteins and cell membranes. Due to these two actions, CoQ10 is commonly used in clinical practice in chronic heart failure, male infertility, and neurodegenerative disease. However, it is also taken as an anti-aging substance by healthy people aiming for long-term neuroprotection and by sportsmen to improve endurance. Many hormones are known to be involved in body energy regulation, in terms of production, consumption and dissipation, and their influence on CoQ10 body content or blood values may represent an important pathophysiological mechanism. We summarize the main findings of the literature about the link between hormonal systems and circulating CoQ10 levels. In particular the role of thyroid hormones, directly involved in the regulation of energy homeostasis, is discussed. There is also a link with gonadal and adrenal hormones, partially due to the common biosynthetic pathway with CoQ10, but also to the increased oxidative stress found in hypogonadism and hypoadrenalism.

  17. Attenuation (1/Q) estimation in reflection seismic records

    International Nuclear Information System (INIS)

    Raji, Wasiu; Rietbrock, Andreas

    2013-01-01

    Despite its numerous potential applications, the lack of a reliable method for determining attenuation (1/Q) in seismic data is an issue when utilizing attenuation for hydrocarbon exploration. In this paper, a new method for measuring attenuation in reflection seismic data is presented. The inversion process involves two key stages: computation of the centroid frequency for the individual signal using a variable window length and fast Fourier transform; and estimation of the difference in the centroid frequency and travel time for paired incident and transmitted signals. The new method introduces a shape factor and a constant which allows several spectral shapes to be used to represent a real seismic signal without altering the mathematical model. Application of the new method to synthetic data shows that it can provide reliable estimates of Q using any of the spectral shapes commonly assumed for real seismic signals. Tested against two published methods of Q measurement, the new method shows less sensitivity to interference from noise and change of frequency bandwidth. The method is also applied to a 3D data set from the Gullfaks field, North Sea, Norway. The trace length is divided into four intervals: AB, BC, CD, and DE. Results show that interval AB has the lowest 1/Q value, and that interval BC has the highest 1/Q value. The values of 1/Q measured in the CDP stack using the new method are consistent with those measured using the classical spectral ratio method. (paper)

  18. Non-linear Q-clouds around Kerr black holes

    International Nuclear Information System (INIS)

    Herdeiro, Carlos; Radu, Eugen; Rúnarsson, Helgi

    2014-01-01

    Q-balls are regular extended ‘objects’ that exist for some non-gravitating, self-interacting, scalar field theories with a global, continuous, internal symmetry, on Minkowski spacetime. Here, analogous objects are also shown to exist around rotating (Kerr) black holes, as non-linear bound states of a test scalar field. We dub such configurations Q-clouds. We focus on a complex massive scalar field with quartic plus hexic self-interactions. Without the self-interactions, linear clouds have been shown to exist, in synchronous rotation with the black hole horizon, along 1-dimensional subspaces – existence lines – of the Kerr 2-dimensional parameter space. They are zero modes of the superradiant instability. Non-linear Q-clouds, on the other hand, are also in synchronous rotation with the black hole horizon; but they exist on a 2-dimensional subspace, delimited by a minimal horizon angular velocity and by an appropriate existence line, wherein the non-linear terms become irrelevant and the Q-cloud reduces to a linear cloud. Thus, Q-clouds provide an example of scalar bound states around Kerr black holes which, generically, are not zero modes of the superradiant instability. We describe some physical properties of Q-clouds, whose backreaction leads to a new family of hairy black holes, continuously connected to the Kerr family

  19. On an Iteration Leading to a q-Analogue of the Digamma Function

    DEFF Research Database (Denmark)

    Berg, Christian; Petersen, Helle Bjerg

    2013-01-01

    We show that the q-Digamma function ψq for 0 < q < 1 appears in an iteration studied by Berg and Durán. This is connected with the determination of the probability measure νq on the unit interval with moments 1/n+1 k=1(1 − q)/(1 − qk), which are q-analogues of the reciprocals of the harmonic numb...

  20. The q-difference operator, the quantum hyperplane, Hilbert spaces of analytic functions and q-oscillators

    International Nuclear Information System (INIS)

    Arik, M.

    1991-01-01

    It is shown that the differential calculus of Wess and Zumino for the quantum hyperplane is intimately related to the q-difference operator acting on the n-dimensional complex space C n . An explicit transformation relates the variables and the q-difference operators on C n to the variables and the quantum derivatives on the quantum hyperplane. For real values of the quantum parameter q, the consideration of the variables and the derivatives as hermitean conjugates yields a quantum deformation of the Bargmann-Segal Hilbert space of analytic functions on C n . Physically such a system can be interpreted as the quantum deformation of the n dimensional harmonic oscillator invariant under the unitary quantum group U q (n) with energy eigenvalues proportional to the basic integers. Finally, a construction of the variables and quantum derivatives on the quantum hyperplane in terms of variables and ordinary derivatives on C n is presented. (orig.)

  1. Hidden correlations entailed by q-non additivity render the q-monoatomic gas highly non trivial

    Science.gov (United States)

    Plastino, A.; Rocca, M. C.

    2018-01-01

    It ts known that Tsallis' q-non-additivity entails hidden correlations. It has also been shown that even for a monoatomic gas, both the q-partition function Z and the mean energy 〈 U 〉 diverge and, in particular, exhibit poles for certain values of the Tsallis non additivity parameter q. This happens because Z and 〈 U 〉 both depend on a Γ-function. This Γ, in turn, depends upon the spatial dimension ν. We encounter three different regimes according to the argument A of the Γ-function. (1) A > 0, (2) A 0 outside the poles. (3) A displays poles and the physics is obtained via dimensional regularization. In cases (2) and (3) one discovers gravitational effects and quartets of particles. Moreover, bound states and gravitational effects emerge as a consequence of the hidden q-correlations.

  2. Apparently balanced t(1;7)(q21.3;q34) in an infant with Coffin-Siris syndrome.

    Science.gov (United States)

    McPherson, E W; Laneri, G; Clemens, M M; Kochmar, S J; Surti, U

    1997-09-05

    Coffin-Siris syndrome is a multiple anomaly/mental retardation syndrome characterized by "coarse" facial appearance, hypoplastic or absent nails on the fifth digits, generalized hirsutism with sparse scalp hair, hypotonia, and developmental delay. Due to several reports of affected sibs with or without a mildly affected parent, both autosomal recessive and autosomal dominant inheritance have been suggested. All previous patients with well-documented Coffin-Siris syndrome are chromosomally normal, and the gene has not been mapped. We report on an infant with typical findings of Coffin-Siris syndrome who also has a de novo apparently balanced translocation of chromosomes 1 and 7, karyotype 46,XY,t(1;7)(q21.3;q34). The parental chromosomes are normal and none of the relatives have signs of Coffin-Siris syndrome. The breakpoints 1q21.3 and 7q34 are suggested as possible locations for a Coffin-Siris gene.

  3. Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor–mediated disease

    Science.gov (United States)

    Chua, Jason P.; Reddy, Satya L.; Yu, Zhigang; Giorgetti, Elisa; Montie, Heather L.; Mukherjee, Sarmistha; Higgins, Jake; McEachin, Richard C.; Robins, Diane M.; Merry, Diane E.; Iñiguez-Lluhí, Jorge A.; Lieberman, Andrew P.

    2015-01-01

    Expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR) causes neuromuscular degeneration in individuals with spinobulbar muscular atrophy (SBMA). PolyQ AR has diminished transcriptional function and exhibits ligand-dependent proteotoxicity, features that have both been implicated in SBMA; however, the extent to which altered AR transcriptional function contributes to pathogenesis remains controversial. Here, we sought to dissociate effects of diminished AR function from polyQ-mediated proteotoxicity by enhancing the transcriptional activity of polyQ AR. To accomplish this, we bypassed the inhibitory effect of AR SUMOylation (where SUMO indicates small ubiquitin-like modifier) by mutating conserved lysines in the polyQ AR that are sites of SUMOylation. We determined that replacement of these residues by arginine enhances polyQ AR activity as a hormone-dependent transcriptional regulator. In a murine model, disruption of polyQ AR SUMOylation rescued exercise endurance and type I muscle fiber atrophy; it also prolonged survival. These changes occurred without overt alterations in polyQ AR expression or aggregation, revealing the favorable trophic support exerted by the ligand-activated receptor. Our findings demonstrate beneficial effects of enhancing the transcriptional function of the ligand-activated polyQ AR and indicate that the SUMOylation pathway may be a potential target for therapeutic intervention in SBMA. PMID:25607844

  4. Effects of q-profile structure on turbulence spreading: A fluctuation intensity transport analysis

    Energy Technology Data Exchange (ETDEWEB)

    Yi, S.; Kwon, J. M. [National Fusion Research Institute, Eoeun-dong, Yuseong-gu, Daejeon 305-333 (Korea, Republic of); Diamond, P. H. [National Fusion Research Institute, Eoeun-dong, Yuseong-gu, Daejeon 305-333 (Korea, Republic of); Center for Astrophysics and Space Sciences and Department of Physics, University of California San Diego, La Jolla, California 92093-0429 (United States); Hahm, T. S. [Department of Nuclear Engineering, Seoul National University, Seoul 151-744 (Korea, Republic of)

    2014-09-15

    This paper studies effects of q-profile structure on turbulence spreading. It reports results of numerical experiments using global gyrokinetic simulations. We examine propagation of turbulence, triggered by an identical linear instability in a source region, into an adjacent, linearly stable region with variable q-profile. The numerical experiments are designed so as to separate the physics of turbulence spreading from that of linear stability. The strength of turbulence spreading is measured by the penetration depth of turbulence. Dynamics of spreading are elucidated by fluctuation intensity balance analysis, using a model intensity evolution equation which retains nonlinear diffusion and damping, and linear growth. It is found that turbulence spreading is strongly affected by magnetic shear s, but is hardly altered by the safety factor q itself. There is an optimal range of modest magnetic shear which maximizes turbulence spreading. For high to modest shear values, the spreading is enhanced by the increase of the mode correlation length with decreasing magnetic shear. However, the efficiency of spreading drops for sufficiently low magnetic shear even though the mode correlation length is comparable to that for the case of optimal magnetic shear. The reduction of spreading is attributed to the increase in time required for the requisite nonlinear mode-mode interactions. The effect of increased interaction time dominates that of increased mode correlation length. Our findings of the reduction of spreading and the increase in interaction time at weak magnetic shear are consistent with the well-known benefit of weak or reversed magnetic shear for core confinement enhancement. Weak shear is shown to promote locality, as well as stability.

  5. Asymptotic representations of augmented q-Onsager algebra and boundary K-operators related to Baxter Q-operators

    Science.gov (United States)

    Baseilhac, Pascal; Tsuboi, Zengo

    2018-04-01

    We consider intertwining relations of the augmented q-Onsager algebra introduced by Ito and Terwilliger, and obtain generic (diagonal) boundary K-operators in terms of the Cartan element of Uq (sl2). These K-operators solve reflection equations. Taking appropriate limits of these K-operators in Verma modules, we derive K-operators for Baxter Q-operators and corresponding reflection equations.

  6. A functional endonuclease Q exists in the bacterial domain: identification and characterization of endonuclease Q from Bacillus pumilus.

    Science.gov (United States)

    Shiraishi, Miyako; Ishino, Sonoko; Cann, Isaac; Ishino, Yoshizumi

    2017-05-01

    DNA base deamination occurs spontaneously under physiological conditions and is promoted by high temperature. Therefore, hyperthermophiles are expected to have efficient repair systems of the deaminated bases in their genomes. Endonuclease Q (EndoQ) was originally identified from the hyperthermophlic archaeon, Pyrococcus furiosus, as a hypoxanthine-specific endonuclease recently. Further biochemical analyses revealed that EndoQ also recognizes uracil, xanthine, and the AP site in DNA, and is probably involved in a specific repair process for damaged bases. Initial phylogenetic analysis showed that an EndoQ homolog is found only in the Thermococcales and some of the methanogens in Archaea, and is not present in most members of the domains Bacteria and Eukarya. A better understanding of the distribution of the EndoQ-mediated repair system is, therefore, of evolutionary interest. We showed here that an EndoQ-like polypeptide from Bacillus pumilus, belonging to the bacterial domain, is functional and has similar properties with the archaeal EndoQs.

  7. Angelman syndrome associated with an inversion of chromosome 15q11.2q24.3

    Energy Technology Data Exchange (ETDEWEB)

    Greger, V.; Knoll, J.H.M.; Wagstaff, J.; Lalande, M. [and others

    1997-03-01

    Angelman syndrome (AS) most frequently results from large ({ge}5 Mb) de novo deletions of chromosome 15q11-q13. The deletions are exclusively of maternal origin, and a few cases of paternal uniparental disomy of chromosome 15 have been reported. The latter finding indicates that AS is caused by the absence of a maternal contribution to the imprinted 15q11-q13 region. Failure to inherit a paternal 15q11-q13 contribution results in the clinically distinct disorder of Prader-Willi syndrome. Cases of AS resulting from translocations or pericentric inversions have been observed to be associated with deletions, and there have been no confirmed reports of balanced rearrangements in AS. We report the first such case involving a paracentric inversion with a breakpoint located {approximately}25 kb proximal to the reference marker D15S10. This inversion has been inherited from a phenotypically normal mother. No deletion is evident by molecular analysis in this case, by use of cloned fragments mapped to within {approximately}1 kb of the inversion breakpoint. Several hypotheses are discussed to explain the relationship between the inversion and the AS phenotype. 47 refs., 3 figs.

  8. A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15 (q32; q13

    Directory of Open Access Journals (Sweden)

    Mohamad Khawandanah

    2014-01-01

    Full Text Available Background. We hereby describe what we believe to be the first reported case of t (14; 15 (q32; q13 associated with acute myeloid leukemia (AML. Methods. PubMed, Embase, and OVID search engines were used to review the related literature and similar published cases. Case. A47-year-old female presented in December 2011 with AML (acute myelomonocytic leukemia with normal cytogenetics; molecular testing revealed FLT-3 internal tandem duplication (ITD mutation, while no mutations involving FLT3 D385/I836, NPM1 exon 12, or KIT exons 8 and 17 were detected. She was induced with 7 + 3 (cytarabine + idarubicin and achieved complete remission after a second induction with high-dose cytarabine (HiDAC followed by uneventful consolidation. She presented 19 months after diagnosis with relapsed disease. Of note, at relapse cytogenetic analysis revealed t (14; 15 (q32; q13, while FLT-3 analysis showed a codon D835 mutation (no ITD mutation was detected. She proved refractory to the initial clofarabine-based regimen, so FLAG-idarubicin then was used. She continued to have persistent disease, and she was discharged on best supportive care. Conclusion. Based on this single case of AML with t (14; 15 (q32; q13, this newly reported translocation may be associated with refractory disease.

  9. Anterior pituitary failure (panhypopituitarism) with balanced chromosome translocation 46,XY,t(11;22)(q24;q13).

    Science.gov (United States)

    Yang, C Y; Chou, C W; Chen, S Y; Cheng, H M

    2001-04-01

    Hypopituitarism is the clinical syndrome that results from failure of the anterior pituitary gland to produce its hormones. Hypopituitarism can result from: (1) intrinsic or primary pituitary disease; (2) intrinsic hypothalamic or secondary pituitary disease; or (3) extrinsic extrasellar or parasellar disease. The etiologies of primary hypopituitarism are miscellaneous. The dominant clinical picture of hypopituitarism in the adult is that of hypogonadism. Reports have associated hypopituitarism with anti-pituitary-antibodies, hereditary syndrome and chromosome defects, but hypopituitarism has rarely been associated with balanced chromosome translocation (11;22)(q24;q13). Here, we describe a case of anterior pituitary failure with balanced chromosome translocation. A 19-year-old Chinese teenager presented with failure of pubertal development and sexual infantilism. On examination, the patient had the classic appearance of hypogonadism. Endocrine studies and three combined pituitary function tests revealed panhypopituitarism. A chromosomal study revealed 46,XY,t(11;22)(q24;q13), a balanced translocation between 11q24 and 22q13. Chest films showed delayed fusion of bilateral humeral head epiphyses and bilateral acromions. Scrotal sonography revealed testes were small bilaterally. Magnetic resonance imaging (MRI) of the sella revealed pituitary dwarfism. The patient received 19 months replacement therapy, including steroids (prednisolone 5 mg each day), L-thyroxine (Eltroxin 100 ug each day), and testosterone enanthate 250 mg every two weeks. His height increased 4 cm with secondary sexual characteristics developed, and muscle power increased.

  10. De novo microdeletions of chromosome 6q14.1-q14.3 and 6q12.1-q14.1 in two patients with intellectual disability - further delineation of the 6q14 microdeletion syndrome and review of the literature

    DEFF Research Database (Denmark)

    Becker, Kerstin; Di Donato, Nataliya; Holder-Espinasse, Muriel

    2012-01-01

    with broad nasal tip, anteverted nares, long philtrum, and thin upper lip. In this study we describe two patients with overlapping 6q14 deletions presenting with developmental delay and characteristic dysmorphism. Molecular karyotyping using array CGH analysis revealed a de novo 8.9 Mb deletion at 6q14.1-q14.......3 and a de novo 11.3 Mb deletion at 6q12.1-6q14.1, respectively. We provide a review of the clinical features of twelve other patients with 6q14 deletions detected by array CGH analysis. By assessing all reported data we could not identify a single common region of deletion. Possible candidate genes in 6q14...

  11. A conserved START domain coenzyme Q-binding polypeptide is required for efficient Q biosynthesis, respiratory electron transport, and antioxidant function in Saccharomyces cerevisiae.

    Science.gov (United States)

    Allan, Christopher M; Hill, Shauna; Morvaridi, Susan; Saiki, Ryoichi; Johnson, Jarrett S; Liau, Wei-Siang; Hirano, Kathleen; Kawashima, Tadashi; Ji, Ziming; Loo, Joseph A; Shepherd, Jennifer N; Clarke, Catherine F

    2013-04-01

    Coenzyme Qn (ubiquinone or Qn) is a redox active lipid composed of a fully substituted benzoquinone ring and a polyisoprenoid tail of n isoprene units. Saccharomyces cerevisiae coq1-coq9 mutants have defects in Q biosynthesis, lack Q6, are respiratory defective, and sensitive to stress imposed by polyunsaturated fatty acids. The hallmark phenotype of the Q-less yeast coq mutants is that respiration in isolated mitochondria can be rescued by the addition of Q2, a soluble Q analog. Yeast coq10 mutants share each of these phenotypes, with the surprising exception that they continue to produce Q6. Structure determination of the Caulobacter crescentus Coq10 homolog (CC1736) revealed a steroidogenic acute regulatory protein-related lipid transfer (START) domain, a hydrophobic tunnel known to bind specific lipids in other START domain family members. Here we show that purified CC1736 binds Q2, Q3, Q10, or demethoxy-Q3 in an equimolar ratio, but fails to bind 3-farnesyl-4-hydroxybenzoic acid, a farnesylated analog of an early Q-intermediate. Over-expression of C. crescentus CC1736 or COQ8 restores respiratory electron transport and antioxidant function of Q6 in the yeast coq10 null mutant. Studies with stable isotope ring precursors of Q reveal that early Q-biosynthetic intermediates accumulate in the coq10 mutant and de novo Q-biosynthesis is less efficient than in the wild-type yeast or rescued coq10 mutant. The results suggest that the Coq10 polypeptide:Q (protein:ligand) complex may serve essential functions in facilitating de novo Q biosynthesis and in delivering newly synthesized Q to one or more complexes of the respiratory electron transport chain. Copyright © 2012 Elsevier B.V. All rights reserved.

  12. Near threshold electroproduction of the ω meson at Q2≅0.5 GeV2

    International Nuclear Information System (INIS)

    Ambrozewicz, P.; Mitchell, J.; Dunne, J.; Abbott, D.J.; Carlini, R.; Ent, R.; Mack, D.J.; Wood, S.; Yan, C.; Markowitz, P.; Martoff, C.J.; Reinhold, J.; Zeidman, B.; Arrington, J.; Bailey, K.; Cummings, W.J.; Gao, H.; Geesaman, D.F.; Hansen, J.-O.; O'Neill, T.G.

    2004-01-01

    Electroproduction of the ω meson was investigated in the 1 H(e,e ' p)ω reaction. The measurement was performed at a four-momentum transfer Q 2 ≅0.5 GeV 2 . Angular distributions of the virtual photon-proton center-of-momentum cross sections have been extracted over the full angular range. These distributions exhibit a strong enhancement over t-channel parity exchange processes in the backward direction. According to a newly developed electroproduction model, this enhancement provides significant evidence of resonance formation in the γ*p→ωp reaction channel

  13. Near threshold electroproduction of the omega meson at Q2 ∼ 0.5 GeV2

    International Nuclear Information System (INIS)

    Ambrozewicz, P.; Mitchell, J.; Dunne, J.; Markowitz, P.; Martoff, C. J.; Reinhold, J.; Zeidman, B.

    2004-01-01

    Electroproduction of the omega meson was investigated in the p(e,e'p)omega reaction. The measurement was performed at a 4-momentum transfer Q2 ∼ 0.5 GeV2. Angular distributions of the virtual photon-proton center-of-momentum cross sections have been extracted over the full angular range. These distributions exhibit a strong enhancement over t-channel parity exchange processes in the backward direction. According to a newly developed electroproduction model, this enhancement provides significant evidence of resonance formation in the gamma* p -> omega p reaction channel

  14. Thrombosis and antiphospholipid antibody syndrome during acute Q fever

    Science.gov (United States)

    Million, Matthieu; Bardin, Nathalie; Bessis, Simon; Nouiakh, Nadia; Douliery, Charlaine; Edouard, Sophie; Angelakis, Emmanouil; Bosseray, Annick; Epaulard, Olivier; Branger, Stéphanie; Chaudier, Bernard; Blanc-Laserre, Karine; Ferreira-Maldent, Nicole; Demonchy, Elisa; Roblot, France; Reynes, Jacques; Djossou, Felix; Protopopescu, Camelia; Carrieri, Patrizia; Camoin-Jau, Laurence; Mege, Jean-Louis; Raoult, Didier

    2017-01-01

    Abstract Q fever is a neglected and potentially fatal disease. During acute Q fever, antiphospholipid antibodies are very prevalent and have been associated with fever, thrombocytopenia, acquired heart valve disease, and progression to chronic endocarditis. However, thrombosis, the main clinical criterion of the 2006 updated classification of the antiphospholipid syndrome, has not been assessed in this context. To test whether thrombosis is associated with antiphospholipid antibodies and whether the criteria for antiphospholipid syndrome can be met in patients with acute Q fever, we conducted a cross-sectional study at the French National Referral Center for Q fever. Patients included were diagnosed with acute Q fever in our Center between January 2007 and December 2015. Each patient's history and clinical characteristics were recorded with a standardized questionnaire. Predictive factors associated with thrombosis were assessed using a rare events logistic regression model. IgG anticardiolipin antibodies (IgG aCL) assessed by an enzyme-linked immunosorbent assay were tested on the Q fever diagnostic serum. A dose-dependent relationship between IgG aCL levels and thrombosis was tested using a receiver operating characteristic (ROC) analysis. Of the 664 patients identified for inclusion in the study, 313 (47.1%) had positive IgG aCL and 13 (1.9%) were diagnosed with thrombosis. Three patients fulfilled the antiphospholipid syndrome criteria. After multiple adjustments, only positive IgG aCL (relative risk, 14.46 [1.85–113.14], P = .011) were independently associated with thrombosis. ROC analysis identified a dose-dependent relationship between IgG aCL levels and occurrence of thrombosis (area under curve, 0.83, 95%CI [0.73–0.93], P antiphospholipid antibodies are associated with thrombosis, thrombocytopenia, and acquired valvular heart disease. Antiphospholipid antibodies should be systematically assessed in acute Q fever patients. Hydroxychloroquine

  15. Obituary: David Q. Wark, 1918-2002

    Science.gov (United States)

    McMillin, Larry Max

    2003-12-01

    David Q. Wark, a research meteorologist at the National Environmental Satellite, Data, and Information Service of the National Oceanic and Atmospheric Administration (NOAA/NESDIS) and its predecessor organizations for 55 years, died of cancer 30 July 2002. He will be long remembered for his seminal contributions to the weather satellite program. A pioneer in the use of satellite sensors to provide observations of the Earth's environment for application to weather forecasting and atmospheric science, Dr. Wark was noted for his brilliant insights, dedication, and exceptional scientific achievements. He developed many of the theoretical and experimental techniques on which NOAA's current multi- billion-dollar meteorological satellite program is based. In the 1960's and early 1970's, he and his NOAA colleague Donald Hilleary were the motivating force and principal investigators for the first satellite instruments dedicated to sounding the atmosphere for temperature and water-vapor. These instruments included the Satellite Infra-Red Spectrometer (SIRS)-A and -B and the Vertical Temperature Profile Radiometer (VTPR), which were flown on NASA's Nimbus satellites and NOAA's ITOS-D satellites, respectively. With colleague Henry Fleming, he formulated the radiative transfer equation that quantifies the spectral radiances of the Earth and its atmosphere (measured at satellite altitude) and inverted that equation mathematically to infer the atmospheric temperature profile from satellite-based measurements of those radiances. A difficulty they had to overcome was that the mathematical problem is ill-posed, i.e., it admits of an infinite number of solutions. They arrived at a unique solution via an innovative application of a-priori information on the atmospheric state. This work was described in the landmark 1965 Wark and Fleming paper in the American Meteorological Society's Monthly Weather Review. From that early period until just weeks before his death, Dr. Wark continued

  16. Review of the Frontier Workshop and Q-slope results

    Energy Technology Data Exchange (ETDEWEB)

    Gianluigi Ciovati

    2005-09-20

    Over the last few years, significant progress has been made to produce field emission free niobium surfaces. Nowadays, the major limitation towards achieving the critical field in radio-frequency (rf) superconducting cavities made of bulk niobium of high purity is represented by the so-called ''high field Q-slope'' or ''Q-drop''. This phenomenon is characterized by a sharp decrease of the cavity quality factor, in absence of field emission, starting at a peak surface magnetic field of the order of 100 mT. It has been observed that these losses are usually reduced by a low-temperature ''in-situ'' baking, typically at 100-120 C for 24-48 h. Several models have been proposed to explain the high field Q-slope and many experiments have been conducted in different laboratories to validate such models. A three-day workshop was held in Argonne in September 2004 to present and discuss experimental and theoretical results on the present limitations of superconducting rf cavities. In this paper, we will focus on the high field Q-slope by reviewing the results presented at the workshop along with other experimental data. In order to explain the Q-drop and the baking effect we will discuss an improved version of the oxygen diffusion model.

  17. Structural Evolution of Q-Carbon and Nanodiamonds

    Science.gov (United States)

    Gupta, Siddharth; Bhaumik, Anagh; Sachan, Ritesh; Narayan, Jagdish

    2018-04-01

    This article provides insights pertaining to the first-order phase transformation involved in the growth of densely packed Q-carbon and nanodiamonds by nanosecond laser melting and quenching of diamond-like carbon (DLC) thin films. DLC films with different sp 3 content were melted rapidly in a controlled way in super-undercooled state and quenched, leading to formation of distinct nanostructures, i.e., nanodiamonds, Q-carbon, and Q-carbon nanocomposites. This analysis provides direct evidence of the dependence of the super-undercooling on the structural evolution of Q-carbon. Finite element heat flow calculations showed that the super-undercooling varies monotonically with the sp 3 content. The phenomenon of solid-liquid interfacial instability during directional solidification from the melt state is studied in detail. The resulting lateral segregation leads to formation of cellular filamentary Q-carbon nanostructures. The dependence of the cell size and wavelength at the onset of instability on the sp 3 content of DLC thin films was modeled based on perturbation theory.

  18. Probabilistic Q-function distributions in fermionic phase-space

    International Nuclear Information System (INIS)

    Rosales-Zárate, Laura E C; Drummond, P D

    2015-01-01

    We obtain a positive probability distribution or Q-function for an arbitrary fermionic many-body system. This is different to previous Q-function proposals, which were either restricted to a subspace of the overall Hilbert space, or used Grassmann methods that do not give probabilities. The fermionic Q-function obtained here is constructed using normally ordered Gaussian operators, which include both non-interacting thermal density matrices and BCS states. We prove that the Q-function exists for any density matrix, is real and positive, and has moments that correspond to Fermi operator moments. It is defined on a finite symmetric phase-space equivalent to the space of real, antisymmetric matrices. This has the natural SO(2M) symmetry expected for Majorana fermion operators. We show that there is a physical interpretation of the Q-function: it is the relative probability for observing a given Gaussian density matrix. The distribution has a uniform probability across the space at infinite temperature, while for pure states it has a maximum value on the phase-space boundary. The advantage of probabilistic representations is that they can be used for computational sampling without a sign problem. (fast track communication)

  19. Ternary q-Virasoro-Witt Hom-Nambu-Lie algebras

    International Nuclear Information System (INIS)

    Ammar, F; Makhlouf, A; Silvestrov, S

    2010-01-01

    In this paper we construct ternary q-Virasoro-Witt algebras which q-deform the ternary Virasoro-Witt algebras constructed by Curtright, Fairlie and Zachos using su(1, 1) enveloping algebra techniques. The ternary Virasoro-Witt algebras constructed by Curtright, Fairlie and Zachos depend on a parameter and are not Nambu-Lie algebras for all but finitely many values of this parameter. For the parameter values for which the ternary Virasoro-Witt algebras are Nambu-Lie, the corresponding ternary q-Virasoro-Witt algebras constructed in this paper are also Hom-Nambu-Lie because they are obtained from the ternary Nambu-Lie algebras using the composition method. For other parameter values this composition method does not yield a Hom-Nambu-Lie algebra structure for q-Virasoro-Witt algebras. We show however, using a different construction, that the ternary Virasoro-Witt algebras of Curtright, Fairlie and Zachos, as well as the general ternary q-Virasoro-Witt algebras we construct, carry a structure of the ternary Hom-Nambu-Lie algebra for all values of the involved parameters.

  20. UNVEILING THE UNIVERSALITY OF I-LOVE-Q RELATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Sham, Y.-H.; Lin, L.-M.; Leung, P. T. [Department of Physics and Institute of Theoretical Physics, The Chinese University of Hong Kong, Hong Kong SAR (China); Chan, T. K., E-mail: yhsham@phy.cuhk.edu.hk, E-mail: chantsangkeung@gmail.com, E-mail: lmlin@phy.cuhk.edu.hk, E-mail: ptleung@phy.cuhk.edu.hk [Present address: Department of Physics, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. (United States)

    2015-01-10

    The recent discovery of the universal I-Love-Q relations connecting the moment of inertia, tidal deformability, and the spin-induced quadrupole moment of compact stars is intriguing and totally unexpected. In this paper, we provide numerical evidence showing that the universality can be attributed to the incompressible limit of the I-Love-Q relations. The fact that modern equations of state are stiff, with an effective adiabatic index larger than about two, above the nuclear density range is the key to establishing the universality for neutron stars and quark stars with typical compactness from about 0.1 to 0.3. On the other hand, the I-Love-Q relations of low-mass neutron stars near the minimum mass limit depend more sensitively on the underlying equation of state because these stars are composed mainly of softer matter at low densities. However, the I-Love-Q relations for low-mass quark stars can still be represented accurately by the incompressible limit. We also study the I-Love relation connecting the moment of inertia and tidal deformability analytically in Newtonian gravity and show why the I-Love-Q relation is weakly dependent on the underlying equation of state and can be attributed to its incompressible limit.