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Sample records for q enhancement

  1. Q-enhanced racetrack microresonators

    Science.gov (United States)

    Chamorro-Posada, P.

    2017-03-01

    A Q-enhancement strategy for racetrack microresonators is put forward. The design is based on the modification of the resonator geometry in order to mitigate the two main sources of radiation loss in the presence of curved waveguides: the discontinuities at the junctions between straight waveguides and the bent sections, and the continuous loss at the curved waveguide sectors. At the same time, the modifications of the geometry do not affect the versatility of coupling of racetrack resonators in integrated optical circuits, which is their main advantage over ring microresonators. The proposal is applied to the design of high-Q racetrack resonators for the silicon nitride CMOS-compatible platform having bent radii amenable for large-scale photonic integration. Numerical calculations show over 100% improvement of the Q factor in Si3N4/SiO2 resonators.

  2. Q-enhanced racetrack micro-resonators

    CERN Document Server

    Chamorro-Posada, Pedro

    2016-01-01

    A Q enhancement strategy for racetrack micro -resonators is put forward. The design is based on the modification of the resonator geometry in order to mitigate the two main sources of radiation loss in the presence of curved waveguides: the couplings from the straight waveguides to the bent sections and the continuous loss at the curved waveguide sectors. Numerical calculations show over $100\\%$ improvement of the Q factor in silicon nitride resonators. At the same time, the modifications of the geometry do not affect the coupling properties of the resonators in integrated optical circuits.

  3. Q-factor enhancement in all-dielectric anisotropic nanoresonators

    CERN Document Server

    Liu, Wei; Kivshar, Yuri S

    2016-01-01

    It is proposed and demonstrated that Q-factor of optical resonators can be significantly enhanced by introducing an extra anisotropic cladding. We study the optical resonances of all-dielectric core-shell nanoresonators and reveal that radially anisotropic claddings can be employed to squeeze more energy into the core area, leading to stronger light confinement and thus significant Q-factor enhancement. We further show that the required homogenous claddings of unusual anisotropy parameters can be realized through all-dielectric multi-layered isotropic structures, which offers realistic extra flexibilities of resonance manipulations for optical resonators.

  4. Q-factor and absorption enhancement for plasmonic anisotropic nanoparticles

    CERN Document Server

    Liu, Wei; Miroshnichenko, Andrey E

    2016-01-01

    We investigate the scattering and absorption properties of anisotropic metal-dielectric core-shell nanoparticles. It is revealed that the radially anisotropic dielectric layer can accelerate the evanescent decay of the localized resonant surface modes, leading to Q-factor and absorption rate enhancement. Moreover, the absorption cross section can be maximized to reach the single resonance absorption limit. We further show that such artificial anisotropic cladding materials can be realized by isotropic layered structures, which may inspire many applications based on scattering and absorption of plasmonic nanoparticles.

  5. Q pili enhance the attachment of Moraxella bovis to bovine corneas in vitro.

    Science.gov (United States)

    Ruehl, W W; Marrs, C; Beard, M K; Shokooki, V; Hinojoza, J R; Banks, S; Bieber, D; Mattick, J S

    1993-01-01

    Moraxella bovis, the causative agent of infectious bovine keratoconjunctivitis, exhibits several virulence factors, including pili, haemolysin, leukotoxin, and proteases. The pili are filamentous appendages which mediate bacterial adherence. Prior studies have shown that Q-piliated M. bovis Epp63 are more infectious and more pathogenic than I-piliated and non-piliated isogenic variants, suggesting that Q pili per se, or traits associated with Q-pilin expression, promote the early association of Q-piliated bacteria with bovine corneal tissue. In order to better evaluate the role of Q pili in M. bovis attachment, several M. bovis strains and a recombinant P. aeruginosa strain which elaborates M. bovis Q pili but not P. aeruginosa PAK pili, were evaluated using an in vitro corneal attachment assay. For each strain tested, piliated organisms attached better than non-piliated bacteria. M. bovis Epp63 Q-piliated bacteria adhered better than either the I-piliated or non-piliated isogenic variants. Finally, recombinant P. aeruginosa organisms elaborating M. bovis Q pili adhered better than the parent P. aeruginosa strain which did not produce M. bovis pili. These results indicate that the presence of pili, especially Q pili, enhances the attachment of bacteria to bovine cornea in vitro.

  6. K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanism.

    Directory of Open Access Journals (Sweden)

    Atsuko Hachiya

    Full Text Available HIV-1 carrying the "Q151M complex" reverse transcriptase (RT mutations (A62V/V75I/F77L/F116Y/Q151M, or Q151Mc is resistant to many FDA-approved nucleoside RT inhibitors (NRTIs, but has been considered susceptible to tenofovir disoproxil fumarate (TFV-DF or TDF. We have isolated from a TFV-DF-treated HIV patient a Q151Mc-containing clinical isolate with high phenotypic resistance to TFV-DF. Analysis of the genotypic and phenotypic testing over the course of this patient's therapy lead us to hypothesize that TFV-DF resistance emerged upon appearance of the previously unreported K70Q mutation in the Q151Mc background. Virological analysis showed that HIV with only K70Q was not significantly resistant to TFV-DF. However, addition of K70Q to the Q151Mc background significantly enhanced resistance to several approved NRTIs, and also resulted in high-level (10-fold resistance to TFV-DF. Biochemical experiments established that the increased resistance to tenofovir is not the result of enhanced excision, as K70Q/Q151Mc RT exhibited diminished, rather than enhanced ATP-based primer unblocking activity. Pre-steady state kinetic analysis of the recombinant enzymes demonstrated that addition of the K70Q mutation selectively decreases the binding of tenofovir-diphosphate (TFV-DP, resulting in reduced incorporation of TFV into the nascent DNA chain. Molecular dynamics simulations suggest that changes in the hydrogen bonding pattern in the polymerase active site of K70Q/Q151Mc RT may contribute to the observed changes in binding and incorporation of TFV-DP. The novel pattern of TFV-resistance may help adjust therapeutic strategies for NRTI-experienced patients with multi-drug resistant (MDR mutations.

  7. Resonance Enhancement in Piezoresponse Force Microscopy: Maping Electromechanical Activity, Contact Stiffness, and Q-Factor

    Energy Technology Data Exchange (ETDEWEB)

    Jesse, Stephen [ORNL; Mirman, B [Suffolk University, Boston; Kalinin, Sergei V [ORNL

    2006-01-01

    Piezoresponse force microscopy (PFM) and spectroscopy of domain structure and switching dynamics at small excitation voltages require resonance enhancement of the surface displacements. The contact stiffness depends strongly on local elastic properties and topography resulting in significant variations of the resonant frequency. Moreover, the resonant response is determined both by the Q factor and the electromechanical activity. Here we develop a resonance-enhanced PFM that allows mapping of the local electromechanical activity, contact stiffness, and loss factor, thus avoiding limitations inherent to conventional frequency tracking. We anticipate that this method will be instrumental in imaging weakly piezoelectric materials and probing inelastic phenomena in ferroelectrics.

  8. Support loss and Q factor enhancement for a rocking mass microgyroscope.

    Science.gov (United States)

    Wang, Xiong; Xiao, Dingbang; Zhou, Zelong; Wu, Xuezhong; Chen, Zhihua; Li, Shengyi

    2011-01-01

    A rocking mass gyroscope (RMG) is a kind of vibrating mass gyroscope with high sensitivity, whose driving mode and sensing mode are completely uniform. MEMS RMG devices are a research hotspot now because they have the potential to be used in space applications. Support loss is the dominant energy loss mechanism influencing their high sensitivity. An accurate analytical model of support loss for RMGs is presented to enhance their Q factors. The anchor type and support loss mechanism of an RMG are analyzed. Firstly, the support loads, powers flowing into support structure, and vibration energy of an RMG are all developed. Then the analytical model of support loss for the RMG is developed, and its sensitivities to the main structural parameters are also analyzed. High-Q design guidelines for rocking mass microgyroscopes are deduced. Finally, the analytical model is validated by the experimental data and the data from the existing literature. The thicknesses of the prototypes are reduced from 240 μm to 60 μm, while Q factors increase from less than 150 to more than 800. The derived model is general and applicable to various beam resonators, providing significant insight to the design of high-Q MEMS devices.

  9. Support Loss and Q Factor Enhancement for a Rocking Mass Microgyroscope

    Directory of Open Access Journals (Sweden)

    Zhihua Chen

    2011-10-01

    Full Text Available A rocking mass gyroscope (RMG is a kind of vibrating mass gyroscope with high sensitivity, whose driving mode and sensing mode are completely uniform. MEMS RMG devices are a research hotspot now because they have the potential to be used in space applications. Support loss is the dominant energy loss mechanism influencing their high sensitivity. An accurate analytical model of support loss for RMGs is presented to enhance their Q factors. The anchor type and support loss mechanism of an RMG are analyzed. Firstly, the support loads, powers flowing into support structure, and vibration energy of an RMG are all developed. Then the analytical model of support loss for the RMG is developed, and its sensitivities to the main structural parameters are also analyzed. High-Q design guidelines for rocking mass microgyroscopes are deduced. Finally, the analytical model is validated by the experimental data and the data from the existing literature. The thicknesses of the prototypes are reduced from 240 µm to 60 µm, while Q factors increase from less than 150 to more than 800. The derived model is general and applicable to various beam resonators, providing significant insight to the design of high-Q MEMS devices.

  10. Enhancing the performance of Q-cascade for separating intermediate components

    Science.gov (United States)

    Zeng, S.; Jiang, D. J.; Zhang, Y. N.; Borisevich, V. D.; Sulaberidze, G. A.; Smirnov, A. Yu

    2016-09-01

    It has been shown recently that Q-cascade with an expansion of the entering flow at the intermediate withdrawal point is able to obtain a concentration of an intermediate component far exceeding the concentration limit available from an end withdrawal. To enhance the applicability of this approach, it is necessary to reduce the relative total flow while maintaining the concentration of the intermediate target component unchanged. Optimization is carried out by using the technique of cascade segmentation, and using the mass numbers of the virtual components in the segments and the lengths of the segments as decision variables. The results demonstrate that the relative total flow is considerably reduced through optimization.

  11. Symmetry enhancements via 5d instantons, qW-algebrae and (1,0) superconformal index

    CERN Document Server

    Benvenuti, Sergio; Ronzani, Massimiliano; Tanzini, Alessandro

    2016-01-01

    We explore N=(1,0) superconformal six-dimensional theories arising from M5-branes probing a transverse A_k singularity. Upon circle compactification to 5 dimensions, we describe this system with a dual pq-web of five-branes and propose the spectrum of basic five-dimensional instanton operators driving global symmetry enhancement. For a single M5-brane, we find that the exact partition function of the 5d quiver gauge theory matches the 6d (1,0) index, which we compute by letter counting. We finally show that S-duality of the pq-web implies new relations among vertex correlators of qW-algebrae.

  12. Functional enhancers at the gene-poor 8q24 cancer-linked locus.

    Directory of Open Access Journals (Sweden)

    Li Jia

    2009-08-01

    Full Text Available Multiple discrete regions at 8q24 were recently shown to contain alleles that predispose to many cancers including prostate, breast, and colon. These regions are far from any annotated gene and their biological activities have been unknown. Here we profiled a 5-megabase chromatin segment encompassing all the risk regions for RNA expression, histone modifications, and locations occupied by RNA polymerase II and androgen receptor (AR. This led to the identification of several transcriptional enhancers, which were verified using reporter assays. Two enhancers in one risk region were occupied by AR and responded to androgen treatment; one contained a single nucleotide polymorphism (rs11986220 that resides within a FoxA1 binding site, with the prostate cancer risk allele facilitating both stronger FoxA1 binding and stronger androgen responsiveness. The study reported here exemplifies an approach that may be applied to any risk-associated allele in non-protein coding regions as it emerges from genome-wide association studies to better understand the genetic predisposition of complex diseases.

  13. Enhancement of spin coherence using Q-factor engineering in semiconductor microdisc lasers.

    Science.gov (United States)

    Ghosh, S; Wang, W H; Mendoza, F M; Myers, R C; Li, X; Samarth, N; Gossard, A C; Awschalom, D D

    2006-04-01

    Semiconductor microcavities offer unique means of controlling light-matter interactions in confined geometries, resulting in a wide range of applications in optical communications and inspiring proposals for quantum information processing and computational schemes. Studies of spin dynamics in microcavities, a new and promising research field, have revealed effects such as polarization beats, stimulated spin scattering and giant Faraday rotation. Here, we study the electron spin dynamics in optically pumped GaAs microdisc lasers with quantum wells and interface-fluctuation quantum dots in the active region. In particular, we examine how the electron spin dynamics are modified by the stimulated emission in the discs, and observe an enhancement of the spin-coherence time when the optical excitation is in resonance with a high-quality (Q approximately 5,000) lasing mode. This resonant enhancement, contrary to expectations from the observed trend in the carrier-recombination time, is then manipulated by altering the cavity design and dimensions. In analogy with devices based on excitonic coherence, this ability to engineer coherent interactions between electron spins and photons may provide new pathways towards spin-dependent quantum optoelectronics.

  14. Two-Stage Design Method for Enhanced Inductive Energy Transmission with Q-Constrained Planar Square Loops.

    Directory of Open Access Journals (Sweden)

    Akaa Agbaeze Eteng

    Full Text Available Q-factor constraints are usually imposed on conductor loops employed as proximity range High Frequency Radio Frequency Identification (HF-RFID reader antennas to ensure adequate data bandwidth. However, pairing such low Q-factor loops in inductive energy transmission links restricts the link transmission performance. The contribution of this paper is to assess the improvement that is reached with a two-stage design method, concerning the transmission performance of a planar square loop relative to an initial design, without compromise to a Q-factor constraint. The first stage of the synthesis flow is analytical in approach, and determines the number and spacing of turns by which coupling between similar paired square loops can be enhanced with low deviation from the Q-factor limit presented by an initial design. The second stage applies full-wave electromagnetic simulations to determine more appropriate turn spacing and widths to match the Q-factor constraint, and achieve improved coupling relative to the initial design. Evaluating the design method in a test scenario yielded a more than 5% increase in link transmission efficiency, as well as an improvement in the link fractional bandwidth by more than 3%, without violating the loop Q-factor limit. These transmission performance enhancements are indicative of a potential for modifying proximity HF-RFID reader antennas for efficient inductive energy transfer and data telemetry links.

  15. Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism

    Directory of Open Access Journals (Sweden)

    Ni Li

    2017-09-01

    Full Text Available Multiple myeloma (MM is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by which it influences tumorigenesis. We show that rs6877329 G > C resides in a predicted enhancer element that physically interacts with the transcription start site of ELL2. The rs6877329-C risk allele is associated with reduced enhancer activity and lowered ELL2 expression. Since ELL2 is critical to the B cell differentiation process, reduced ELL2 expression is consistent with inherited genetic variation contributing to arrest of plasma cell development, facilitating MM clonal expansion. These data provide evidence for a biological mechanism underlying a hereditary risk of MM at 5q15.

  16. Preparation and Characterization of Mucoadhesive Nanoparticles for Enhancing Cellular Uptake of Coenzyme Q10.

    Science.gov (United States)

    Lee, Ji-Soo; Suh, Ji Woon; Kim, Eun Suh; Lee, Hyeon Gyu

    2017-10-02

    The mucoadhesive nanoparticles (NPs) for oral delivery of coenzyme Q10 (CoQ10) were prepared using natural mucoadhesive polysaccharides, chitosan (CS), and dextran sulfate sodium salt (DS) in order to improve the solubility, cellular uptake, and thermo- and photostability of CoQ10. CoQ10-loaded NPs were prepared in the range of 340-450 nm with an entrapment efficiency of 60-98%. The mucoadhesiveness and cellular uptake of NPs were evaluated by measuring the amount of mucin adsorbed on NPs and CoQ10 absorbed in Caco-2 cells, respectively. CS/DS NPs had higher mucoadhesive strength than CS/sodium triphosphate pentabasic NPs (control group). Moreover, the solubility, cellular uptake, thermo- and photostability of CS/DS NPs were significantly improved compared with non-nanoencapsulated free CoQ10. Particularly, CS/DS NPs prepared with 0.5 mg/mL of CS and DS produced the highest mucoadhesiveness, solubility, cellular uptake, and cellular antioxidant activity. Thus, mucoadhesive CS/DS NPs may be an effective oral delivery platform for improving bioavailability of CoQ10.

  17. Purcell enhancement of fast-dephasing spontaneous emission from electron-hole droplets in high-Q silicon photonic crystal nanocavities

    Science.gov (United States)

    Sumikura, Hisashi; Kuramochi, Eiichi; Taniyama, Hideaki; Notomi, Masaya

    2016-11-01

    We have observed electron-hole droplet emission enhanced by silicon photonic crystal nanocavities with different Q values and simulated their Purcell effect using a semiclassical theory considering the temporal dephasing of the emission. When the photon loss rate of the nanocavities is smaller than the dephasing rate of the emission, the cavity-enhanced integrated photoluminescence (PL) intensity is unchanged by the cavity Q value. This is because the Purcell enhancement of the spontaneous emission rate is saturated in a high-Q region. In contrast, the peak intensity of the cavity-enhanced PL is proportional to the cavity Q value without saturation. These results suggest that a high-Q nanocavity is suitable for fabricating bright narrowband light emitting devices that concentrate the broadband emission energy of fast-dephasing emitters in a narrowband cavity resonance.

  18. Deletion of degQ gene enhances outer membrane vesicle production of Shewanella oneidensis cells.

    Science.gov (United States)

    Ojima, Yoshihiro; Mohanadas, Thivagaran; Kitamura, Kosei; Nunogami, Shota; Yajima, Reiki; Taya, Masahito

    2017-04-01

    Shewanella oneidensis is a Gram-negative facultative anaerobe that can use a wide variety of terminal electron acceptors for anaerobic respiration. In this study, S. oneidensis degQ gene, encoding a putative periplasmic serine protease, was cloned and expressed. The activity of purified DegQ was inhibited by diisopropyl fluorophosphate, a typical serine protease-specific inhibitor, indicating that DegQ is a serine protease. In-frame deletion and subsequent complementation of the degQ were carried out to examine the effect of envelope stress on the production of outer membrane vesicles (OMVs). Analysis of periplasmic proteins from the resulting S. oneidensis strain showed that deletion of degQ induced protein accumulation and resulted in a significant decrease in protease activity within the periplasmic space. OMVs from the wild-type and mutant strains were purified and observed by transmission electron microscopy. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of the OMVs showed a prominent band at ~37 kDa. Nanoliquid chromatography-tandem mass spectrometry analysis identified three outer membrane porins (SO3896, SO1821, and SO3545) as dominant components of the band, suggesting that these proteins could be used as indices for comparing OMV production by S. oneidensis strains. Quantitative evaluation showed that degQ-deficient cells had a fivefold increase in OMV production compared with wild-type cells. Thus, the increased OMV production following the deletion of DegQ in S. oneidensis may be responsible for the increase in envelope stress.

  19. Ultrahigh-Q circular-side square resonator lasers with enhanced transverse mode interval

    CERN Document Server

    Weng, Hai-Zhong; Yang, Yue-De; Ma, Xiu-Wen; Xiao, Jin-Long; Du, Yun

    2015-01-01

    A mechanism of transverse mode control is proposed for circular-side square resonator (CSR) with the flat sides replaced by arcs, which results in ultrahigh-Q factors and large transverse mode intervals according to two and three dimensional (2D and 3D) simulations. A 2D numerical optimization shows that mode Q factors up to 1011 can be obtained for the 16-{\\mu}m-side-length CSR with a 1.5-{\\mu}m-width output waveguide. Dual-mode lasing with frequency intervals in THz range in agreement with simulated results is achieved for AlGaInAs/InP CSR lasers.

  20. Toward enhanced MIQE compliance: reference residual normalization of qPCR gene expression data.

    Science.gov (United States)

    Edmunds, Richard C; McIntyre, Jenifer K; Luckenbach, J Adam; Baldwin, David H; Incardona, John P

    2014-07-01

    Normalization of fluorescence-based quantitative real-time PCR (qPCR) data varies across quantitative gene expression studies, despite its integral role in accurate data quantification and interpretation. Identification of suitable reference genes plays an essential role in accurate qPCR normalization, as it ensures that uncorrected gene expression data reflect normalized data. The reference residual normalization (RRN) method presented here is a modified approach to conventional 2(-ΔΔCt)qPCR normalization that increases mathematical transparency and incorporates statistical assessment of reference gene stability. RRN improves mathematical transparency through the use of sample-specific reference residuals (RR i ) that are generated from the mean Ct of one or more reference gene(s) that are unaffected by treatment. To determine stability of putative reference genes, RRN uses ANOVA to assess the effect of treatment on expression and subsequent equivalence-threshold testing to establish the minimum permitted resolution. Step-by-step instructions and comprehensive examples that demonstrate the influence of reference gene stability on target gene normalization and interpretation are provided. Through mathematical transparency and statistical rigor, RRN promotes compliance with Minimum Information for Quantitative Experiments and, in so doing, provides increased confidence in qPCR data analysis and interpretation.

  1. Activation of Wnt signaling pathway by AF1q enriches stem-like population and enhance mammosphere formation of breast cells.

    Science.gov (United States)

    Tse, Charlotte Olivia; Kim, Soojin; Park, Jino

    2017-03-18

    Wnt signaling pathway is believed to be responsible for control over various types of stem cells and may act as a niche factor to maintain stem cells in a self-renewing state. Moreover, dysregulated Wnt signaling pathway is strongly associated with several diseases including cancer. Previously, we have shown that AF1q associates with a poor prognosis in leukemia, myelodysplastic syndromes, multiple myeloid, ovarian cancer, and breast cancer. Also, AF1q plays a pivotal role as an oncogene and metastasis enhancer in breast cancer via activation of Wnt signaling pathway. AF1q is highly expressed in stem cells, and this expression is diminished by differentiation. To understand the role of AF1q in stem-like population, we examined stem-like cells derived from breast cells which dysregulated Wnt signaling pathway by alteration of AF1q expression. The effect of Wnt signaling pathway by AF1q on EMT marker expression, stem cell marker expression, and sphere formation was determined. Activated Wnt signaling pathway by AF1q enriched stem-like population showed enhanced sphere formation ability. Interestingly, Wnt signaling pathway inhibitor, Quercetin, decreased the sphere formation in these cells. These results suggest that AF1q would have a role as an enhancer in generation of stem-like population through activation of Wnt signaling pathway.

  2. Enhanced antitumor efficacy and counterfeited cardiotoxicity of combinatorial oral therapy using Doxorubicin- and Coenzyme Q10-liquid crystalline nanoparticles in comparison with intravenous Adriamycin

    DEFF Research Database (Denmark)

    Swarnakar, Nitin K; Thanki, Kaushik; Jain, Sanyog

    2014-01-01

    UNLABELLED: Present study focuses on enhancing oral antitumor efficacy and safety of Dox-LCNPs in combination with CoQ10-LCNPs. Drug-loaded-LCNPs were prepared by solvent-diffusion-evaporation method and optimized. Median effect analysis suggested dose-reduction-index of 16.84- and 5.047-fold and...... Q10 and doxorubicin. The nano-conjugates not only provided an enhanced oral treatment option for a tumor model, but prevented cardiotoxicity, a major complication of this drug when delivered via conventional methods....

  3. Enhanced Maternal Origin of the 22q11.2 Deletion in Velocardiofacial and DiGeorge Syndromes

    DEFF Research Database (Denmark)

    Delio, Maria; Guo, Tingwei; McDonald-McGinn, Donna M

    2013-01-01

    Velocardiofacial and DiGeorge syndromes, also known as 22q11.2 deletion syndrome (22q11DS), are congenital-anomaly disorders caused by a de novo hemizygous 22q11.2 deletion mediated by meiotic nonallelic homologous recombination events between low-copy repeats, also known as segmental duplications...

  4. Kazinol Q from Broussonetia kazinoki Enhances Cell Death Induced by Cu(ll through Increased Reactive Oxygen Species

    Directory of Open Access Journals (Sweden)

    Hsue-Yin Hsu

    2011-04-01

    Full Text Available The ability of the flavan kazinol Q (KQ to induce DNA breakage in the presence of Cu(II was examined by agarose gel electrophoresis using supercoiled plasmid DNA. In KQ-mediated DNA breakage reaction, the involvement of reactive oxygen species (ROS, H2O2 and O2 - was established by the inhibition of DNA breakage by catalase and revealed DNA breakage by superoxide dismutase (SOD. The cell viability of gastric carcinoma SCM-1 cells treated with various concentrations of KQ was significantly decreased by cotreatment with Cu(II. Treatment of SCM-1 cells with 300 μM Cu(II enhanced the necrosis induced by 100 μM KQ. Treatment of SCM-1 cells with 100 mM KQ in the presence of 300 mM Cu(II increased the generation of H2O2. Taken together, the above finding suggested that KQ cotreatment with Cu(II produced increased amounts of H2O2, thus enhancing subsequent cell death due to necrosis.

  5. Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers

    DEFF Research Database (Denmark)

    French, Juliet D; Ghoussaini, Maya; Edwards, Stacey L

    2013-01-01

    Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for estrogen-receptor-positive tumors at 11q13. The strongest signal maps to a transcriptional enhancer element in which the G allele of the best candidate causativ...

  6. A-189 dBc/Hz FoMT Wide Tuning Range VCO Using Q-Factor Enhancement Technique

    Science.gov (United States)

    Liu, Faen; Wang, Zhigong; Li, Zhiqun; Li, Qin; Wang, Rong; Yang, Geliang; Li, Zhu

    2015-06-01

    A 28-GHz voltage-controlled oscillator (VCO) with a wide tuning range and a low phase noise is presented in this paper. A PMOS-only cross-coupled pair with a lower flicker noise is exploited to provide the negative resistance. The mechanisms for enhancing the Q-factor of the LC tank at millimeter-wave (mm-wave) frequencies are analyzed and applied to optimize the proposed VCO design to obtain a low phase noise. To guarantee accurate oscillating frequencies, distributed interconnections are carefully modeled by EM simulations. Fabricated in a standard 90-nm CMOS process, the proposed VCO achieves a wide tuning range of 20.1 %, from 25 to 30.66 GHz and a low phase noise of -105.47 dBc/Hz at 1-MHz offset. The current of the core circuit is 10.5 mA under a single 1.2-V supply. The core area of the chip is 0.38 mm × 0.24 mm.

  7. Enhancement of Transdermal Drug Delivery by ns Q-swithed Nd:YAG Laser-induced Pressure Wave

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    A non-invasive laser enhancing transdermal drug delivery technique has been investigated. The second harmonic wavelength of 532 nm of a Q-Switched Nd:YAG laser with pulse duration of 15 ns was used to irradiate on a black polyethylene sheet covering on the surface of the drug solution, and hence produced pressure waves in the solution. Porcine skin and Rhodamine B were used as skin model and reagent respectively.Fluorescence microscope was employed to examine the mechanisms of drug delivery via the skin samples after laser treatment. The experiment revealed that the penetration depth of Rhodamine B under the illumination of laser increased with the energy density of the laser beam. After 20 laser shots at laser energy density of 70 mJ/cm2, the penetration depth reached 440 μm in 30 minutes, which was about three times as that without laser illumination. One possible explanation was that laser-induced pressure waves formed microchannels in the stratum corneum of the skin tissue. These microchannels provided much more effective paths for infiltration of Rhodamine B through the SC than follicular and intercellular paths. The drug solution diffused into the SC under the concentration gradient through the channels.

  8. On Q

    NARCIS (Netherlands)

    Visser, A.

    In this paper we study the theory Q. We prove a basic result that says that, in a sense explained in the paper, Q can be split into two parts. We prove some consequences of this result. (i) Q is not a poly-pair theory. This means that, in a strong sense, pairing cannot be defined in Q. (ii) Q does

  9. On Q

    NARCIS (Netherlands)

    Visser, A.

    2015-01-01

    In this paper we study the theory Q. We prove a basic result that says that, in a sense explained in the paper, Q can be split into two parts. We prove some consequences of this result. (i) Q is not a poly-pair theory. This means that, in a strong sense, pairing cannot be defined in Q. (ii) Q does

  10. Prospective comparative evaluation of quantitative-elastosonography (Q-elastography) and contrast-enhanced ultrasound for the evaluation of thyroid nodules: Preliminary experience

    Energy Technology Data Exchange (ETDEWEB)

    Cantisani, V., E-mail: vito.cantisani@uniroma1.it [Department of Radiology, Oncology, and Anatomy Pathology, University “La Sapienza”, Rome (Italy); Consorti, F. [Department of Surgical Sciences, University “La Sapienza”, Rome (Italy); Guerrisi, A.; Guerrisi, I.; Ricci, P.; Di Segni, M.; Mancuso, E. [Department of Radiology, Oncology, and Anatomy Pathology, University “La Sapienza”, Rome (Italy); Scardella, L.; Milazzo, F. [Department of Surgical Sciences, University “La Sapienza”, Rome (Italy); D’Ambrosio, F. [Department of Radiology, Oncology, and Anatomy Pathology, University “La Sapienza”, Rome (Italy); Antonaci, A. [Department of Surgical Sciences, University “La Sapienza”, Rome (Italy)

    2013-11-01

    Purpose: To assess the effectiveness of semiquantitative elastosonography (Q-elastography) compared with contrast-enhanced ultrasound (CEUS) in differentiating the nature of thyroid nodules. Methods and materials: Forty-eight consecutive patients (35 males, 13 females, range: 34–69 years, mean: 49.4 years), candidate to surgery, previously detected at color-Doppler ultrasound (CDUS), were prospectively examined with elastosonography with dedicated semiquantitative software (Q-Elastography, Toshiba XG) and CEUS (Technos Mylab 70 Gold X, and Toshiba XG) before surgery. CEUS and elastosonography were evaluated by two investigators in consensus. Comparison between the CEUS pattern and elastonographic strain ratio observed and expected frequencies for the diagnoses was evaluated with χ{sup 2} test or with Fisher exact test. Results: Fifty-three nodules (19 papillary carcinoma, 32 hyperplasia, and 2 follicular adenoma) in 48 patients were available for analysis. Regarding echogenicity score, sensitivity, specificity, PPV and NPV of conventional US were 81%, 50%, 56%, 77%; according to Q-elastography, sensitivity, specificity, PPV and NPV were 95%, 88%, 97% and 91% respectively; whereas concerning CEUS, sensitivity specificity PPV and NPV were 79%, 91%, 83% and 89% respectively. Both CEUS and Q-elastography were more specific than US (p < 0.01), with not statistical significant difference with regard to sensitivity. Conclusions: The results of the present study suggest that Q-elastography is a valuable tool in the characterization of thyroid nodules and it seems to be more sensitive than CEUS.

  11. An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression.

    Science.gov (United States)

    Wyszynski, Asaf; Hong, Chi-Chen; Lam, Kristin; Michailidou, Kyriaki; Lytle, Christian; Yao, Song; Zhang, Yali; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Hopper, John L; Southey, Melissa C; Schmidt, Marjanka K; Broeks, Annegien; Muir, Kenneth; Lophatananon, Artitaya; Fasching, Peter A; Beckmann, Matthias W; Peto, Julian; Dos-Santos-Silva, Isabel; Sawyer, Elinor J; Tomlinson, Ian; Burwinkel, Barbara; Marme, Frederik; Guénel, Pascal; Truong, Thérèse; Bojesen, Stig E; Nordestgaard, Børge G; González-Neira, Anna; Benitez, Javier; Neuhausen, Susan L; Brenner, Hermann; Dieffenbach, Aida Karina; Meindl, Alfons; Schmutzler, Rita K; Brauch, Hiltrud; Nevanlinna, Heli; Khan, Sofia; Matsuo, Keitaro; Ito, Hidemi; Dörk, Thilo; Bogdanova, Natalia V; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kosma, Veli-Matti; Wu, Anna H; Van Den Berg, David; Lambrechts, Diether; Wildiers, Hans; Chang-Claude, Jenny; Rudolph, Anja; Radice, Paolo; Peterlongo, Paolo; Couch, Fergus J; Olson, Janet E; Giles, Graham G; Milne, Roger L; Haiman, Christopher A; Henderson, Brian E; Dumont, Martine; Teo, Soo Hwang; Wong, Tien Y; Kristensen, Vessela; Zheng, Wei; Long, Jirong; Winqvist, Robert; Pylkäs, Katri; Andrulis, Irene L; Knight, Julia A; Devilee, Peter; Seynaeve, Caroline; García-Closas, Montserrat; Figueroa, Jonine; Klevebring, Daniel; Czene, Kamila; Hooning, Maartje J; van den Ouweland, Ans M W; Darabi, Hatef; Shu, Xiao-Ou; Gao, Yu-Tang; Cox, Angela; Blot, William; Signorello, Lisa B; Shah, Mitul; Kang, Daehee; Choi, Ji-Yeob; Hartman, Mikael; Miao, Hui; Hamann, Ute; Jakubowska, Anna; Lubinski, Jan; Sangrajrang, Suleeporn; McKay, James; Toland, Amanda E; Yannoukakos, Drakoulis; Shen, Chen-Yang; Wu, Pei-Ei; Swerdlow, Anthony; Orr, Nick; Simard, Jacques; Pharoah, Paul D P; Dunning, Alison M; Chenevix-Trench, Georgia; Hall, Per; Bandera, Elisa; Amos, Chris; Ambrosone, Christine; Easton, Douglas F; Cole, Michael D

    2016-09-01

    Breast cancer is the most diagnosed malignancy and the second leading cause of cancer mortality in females. Previous association studies have identified variants on 2q35 associated with the risk of breast cancer. To identify functional susceptibility loci for breast cancer, we interrogated the 2q35 gene desert for chromatin architecture and functional variation correlated with gene expression. We report a novel intergenic breast cancer risk locus containing an enhancer copy number variation (enCNV; deletion) located approximately 400Kb upstream to IGFBP5, which overlaps an intergenic ERα-bound enhancer that loops to the IGFBP5 promoter. The enCNV is correlated with modified ERα binding and monoallelic-repression of IGFBP5 following oestrogen treatment. We investigated the association of enCNV genotype with breast cancer in 1,182 cases and 1,362 controls, and replicate our findings in an independent set of 62,533 cases and 60,966 controls from 41 case control studies and 11 GWAS. We report a dose-dependent inverse association of 2q35 enCNV genotype (percopy OR = 0.68 95%CI 0.55-0.83, P = 0.0002; replication OR = 0.77 95% CI 0.73-0.82, P = 2.1 × 10(-19)) and identify 13 additional linked variants (r(2 )>( )0.8) in the 20Kb linkage block containing the enCNV (P = 3.2 × 10(-15) - 5.6 × 10(-17)). These associations were independent of previously reported 2q35 variants, rs13387042/rs4442975 and rs16857609, and were stronger for ER-positive than ER-negative disease. Together, these results suggest that 2q35 breast cancer risk loci may be mediating their effect through IGFBP5.

  12. On Q

    NARCIS (Netherlands)

    Visser, Albert

    2015-01-01

    In this paper we study Robinson’s Arithmetic Q. We prove a basic result that says that, in a sense explained in the paper, Q can be split into two parts. We prove some consequences of this result. (i) Q is not a poly-pair theory. This means that, in a strong sense, pairing cannot be defined in Q.

  13. Enhancement of Q(m) by co-doping of Li and Cu to potassium sodium niobate lead-free ceramics.

    Science.gov (United States)

    Li, E; Kakemoto, H; Wada, S; Tsurumi, T

    2008-05-01

    Lead-free piezoelectric ceramics KNN modified by Li-substitution and CuO addition have been synthesized, and the piezoelectric and dielectric properties were measured. A morphotropic phase boundary (MPB) between orthorhombic and tetragonal phases was formed with Li-substitution. The co doping of Li and Cu markedly enhanced the mechanical quality factor (Q(m)) in comparison with the sole doping of Li and Cu. Anomalous anti ferroelectric-like hysteresis curves were observed in 2 mol% CuO-doped ceramics. The anti-ferroelectric-like curves were changed to that of normal ferroelectrics following poling. A model based on the formation of the internal bias field (Ei) due to the movements of space charges was proposed to explain these phenomena. It was considered that the Ei stabilized the spontaneous polarization (Ps) and suppressed the domain wall motion to enhance the Q(m). The highest Qm obtained in this study was 742. The [(Na0(0.5)K0(0.5))(0.96)Li0(0.04) ] NbO(3) + 0.45 mol% CuO ceramics showed a high Q(m) value of 414 with a high piezoelectric constant d(33) of 100 pC/N.

  14. Q-factor enhancement of integrated lithium-niobate-on-insulator ridge waveguide whispering-gallery-mode resonators by surface polishing

    Science.gov (United States)

    Wolf, Richard; Breunig, Ingo; Zappe, Hans; Buse, Karsten

    2017-02-01

    Whispering-gallery resonators (WGRs) are most promising for nonlinear-optical frequency-conversion due to their intensity enhancement by small mode volumes and high Q-factors. This has been shown frequently by millimeter-sized diamond-blade cut and polished bulk WGRs. For reproducible batch fabrication, however, the integration of WGRs into lithium-niobate-on-insulator (LNOI) substrates became of great interest. Here we report on integrated WGRs made by batch processes like lithography and reactive-ion etching. Since the Q-factor of integrated WGRs is limited by scattering losses, we focused on developing a polishing process for the waveguide sidewalls that allowed us to enhance the unloaded Q-factors already to more than 106 with room for further improvements. Furthermore we employ a coupling scheme with two waveguide chips, one comprising a linear coupling waveguide and one with the integrated WGR. By adjusting the distance between the coupling waveguide and the WGR, we can reproducibly and stably tune the coupling-efficiency between 0 and 95 %.

  15. Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression

    NARCIS (Netherlands)

    H. Darabi (Hatef); K. McCue (Karen); J. Beesley (Jonathan); K. Michailidou (Kyriaki); S. Nord (Silje); S. Kar (Siddhartha); K. Humphreys (Keith); D. Thompson (Deborah); M. Ghoussaini (Maya); M.K. Bolla (Manjeet); J. Dennis (Joe); Q. Wang (Qing); S. Canisius (Sander); C.G. Scott (Christopher G.); C. Apicella (Carmel); J. Hopper (John); M.C. Southey (Melissa); J. Stone (Jennifer); A. Broeks (Annegien); M.K. Schmidt (Marjanka); R.J. Scott (Rodney J.); A. Lophatananon (Artitaya); K.R. Muir (K.); M.W. Beckmann (Matthias W.); A.B. Ekici (Arif); P.A. Fasching (Peter); K. Heusinger (Katharina); I. dos Santos Silva (Isabel); J. Peto (Julian); I.P. Tomlinson (Ian); E.J. Sawyer (Elinor); B. Burwinkel (Barbara); F. Marme (Federick); P. Guénel (Pascal); T. Truong (Thérèse); S.E. Bojesen (Stig); H. Flyger (Henrik); J. Benítez (Javier); A. González-Neira (Anna); H. Anton-Culver (Hoda); S.L. Neuhausen (Susan); V. Arndt (Volker); H. Brenner (Hermann); C. Engel (Christoph); A. Meindl (Alfons); R.K. Schmutzler (Rita); N. Arnold (Norbert); H. Brauch (Hiltrud); U. Hamann (Ute); J. Chang-Claude (Jenny); S. Khan (Sofia); H. Nevanlinna (Heli); H. Ito (Hidemi); K. Matsuo (Keitaro); N.V. Bogdanova (Natalia); T. Dörk (Thilo); A. Lindblom (Annika); S. Margolin (Sara); V-M. Kosma (Veli-Matti); A. Mannermaa (Arto); C.-C. Tseng (Chiu-chen); A.H. Wu (Anna H.); O.A.M. Floris; D. Lambrechts (Diether); A. Rudolph (Anja); P. Peterlongo (Paolo); P. Radice (Paolo); F.J. Couch (Fergus); C. Vachon (Celine); G.G. Giles (Graham G.); C.A. McLean (Catriona Ann); R.L. Milne (Roger L.); P.-A. Dugué (Pierre-Antoine); C.A. Haiman (Christopher); G. Maskarinec (Gertraud); C. Woolcott (Christy); B.E. Henderson (Brian); M.S. Goldberg (Mark); J. Simard (Jacques); S.-H. Teo; S. Mariapun (Shivaani); Å. Helland (Åslaug); V. Haakensen (Vilde); W. Zheng (Wei); A. Beeghly-Fadiel (Alicia); R. Tamimi (Rulla); A. Jukkola-Vuorinen (Arja); R. Winqvist (Robert); I.L. Andrulis (Irene); J.A. Knight (Julia); P. Devilee (Peter); R.A.E.M. Tollenaar (Rob); J.D. Figueroa (Jonine); M. García-Closas (Montserrat); K. Czene (Kamila); M.J. Hooning (Maartje); M.M.A. Tilanus-Linthorst (Madeleine); J. Li (J.); Y.-T. Gao (Yu-Tang); X.-O. Shu (Xiao-Ou); A. Cox (Angela); S.S. Cross (Simon); R.N. Luben (Robert); K.T. Khaw; J.-Y. Choi (J.); D. Kang (Daehee); J.M. Hartman (Joost); W.-Y. Lim (Wei-Yen); M. Kabisch (Maria); D. Torres (Diana); A. Jakubowska (Anna); J. Lubinski (Jan); J.D. McKay (James); S. Sangrajrang (Suleeporn); A.E. Toland (Amanda); D. Yannoukakos (Drakoulis); C-Y. Shen (Chen-Yang); J-C. Yu (Jyh-Cherng); A. Ziogas (Argyrios); M. Schoemaker (Minouk); A.J. Swerdlow (Anthony ); A.-L. Borresen-Dale (Anne-Lise); V. Kristensen (Vessela); J.D. French (Juliet); S.L. Edwards (Stacey); A.M. Dunning (Alison); D.F. Easton (Douglas); P. Hall (Per); G. Chenevix-Trench (Georgia)

    2015-01-01

    textabstractGenome-wide association studies have identified SNPs near ZNF365 at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association signal by genotyping 428 SNPs across the region in 89,050 Europea

  16. Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression

    NARCIS (Netherlands)

    H. Darabi (Hatef); K. McCue (Karen); J. Beesley (Jonathan); K. Michailidou (Kyriaki); S. Nord (Silje); S. Kar (Siddhartha); K. Humphreys (Keith); D. Thompson (Deborah); M. Ghoussaini (Maya); M.K. Bolla (Manjeet); J. Dennis (Joe); Q. Wang (Qing); S. Canisius (Sander); C.G. Scott (Christopher G.); C. Apicella (Carmel); J. Hopper (John); M.C. Southey (Melissa); J. Stone (Jennifer); A. Broeks (Annegien); M.K. Schmidt (Marjanka); R.J. Scott (Rodney J.); A. Lophatananon (Artitaya); K.R. Muir (K.); M.W. Beckmann (Matthias W.); A.B. Ekici (Arif); P.A. Fasching (Peter); K. Heusinger (Katharina); I. dos Santos Silva (Isabel); J. Peto (Julian); I.P. Tomlinson (Ian); E.J. Sawyer (Elinor); B. Burwinkel (Barbara); F. Marme (Federick); P. Guénel (Pascal); T. Truong (Thérèse); S.E. Bojesen (Stig); H. Flyger (Henrik); J. Benítez (Javier); A. González-Neira (Anna); H. Anton-Culver (Hoda); S.L. Neuhausen (Susan); V. Arndt (Volker); H. Brenner (Hermann); C. Engel (Christoph); A. Meindl (Alfons); R.K. Schmutzler (Rita); N. Arnold (Norbert); H. Brauch (Hiltrud); U. Hamann (Ute); J. Chang-Claude (Jenny); S. Khan (Sofia); H. Nevanlinna (Heli); H. Ito (Hidemi); K. Matsuo (Keitaro); N.V. Bogdanova (Natalia); T. Dörk (Thilo); A. Lindblom (Annika); S. Margolin (Sara); V-M. Kosma (Veli-Matti); A. Mannermaa (Arto); C.-C. Tseng (Chiu-chen); A.H. Wu (Anna H.); O.A.M. Floris; D. Lambrechts (Diether); A. Rudolph (Anja); P. Peterlongo (Paolo); P. Radice (Paolo); F.J. Couch (Fergus); C. Vachon (Celine); G.G. Giles (Graham G.); C.A. McLean (Catriona Ann); R.L. Milne (Roger L.); P.-A. Dugué (Pierre-Antoine); C.A. Haiman (Christopher); G. Maskarinec (Gertraud); C. Woolcott (Christy); B.E. Henderson (Brian); M.S. Goldberg (Mark); J. Simard (Jacques); S.-H. Teo; S. Mariapun (Shivaani); Å. Helland (Åslaug); V. Haakensen (Vilde); W. Zheng (Wei); A. Beeghly-Fadiel (Alicia); R. Tamimi (Rulla); A. Jukkola-Vuorinen (Arja); R. Winqvist (Robert); I.L. Andrulis (Irene); J.A. Knight (Julia); P. Devilee (Peter); R.A.E.M. Tollenaar (Rob); J.D. Figueroa (Jonine); M. García-Closas (Montserrat); K. Czene (Kamila); M.J. Hooning (Maartje); M.M.A. Tilanus-Linthorst (Madeleine); J. Li (J.); Y.-T. Gao (Yu-Tang); X.-O. Shu (Xiao-Ou); A. Cox (Angela); S.S. Cross (Simon); R.N. Luben (Robert); K.T. Khaw; J.-Y. Choi (J.); D. Kang (Daehee); J.M. Hartman (Joost); W.-Y. Lim (Wei-Yen); M. Kabisch (Maria); D. Torres (Diana); A. Jakubowska (Anna); J. Lubinski (Jan); J.D. McKay (James); S. Sangrajrang (Suleeporn); A.E. Toland (Amanda); D. Yannoukakos (Drakoulis); C-Y. Shen (Chen-Yang); J-C. Yu (Jyh-Cherng); A. Ziogas (Argyrios); M. Schoemaker (Minouk); A.J. Swerdlow (Anthony ); A.-L. Borresen-Dale (Anne-Lise); V. Kristensen (Vessela); J.D. French (Juliet); S.L. Edwards (Stacey); A.M. Dunning (Alison); D.F. Easton (Douglas); P. Hall (Per); G. Chenevix-Trench (Georgia)

    2015-01-01

    textabstractGenome-wide association studies have identified SNPs near ZNF365 at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association signal by genotyping 428 SNPs across the region in 89,050

  17. Performance enhancement of sub-nanosecond diode-pumped passively Q-switched Yb:YAG microchip laser with diamond surface cooling.

    Science.gov (United States)

    Zhuang, W Z; Chen, Yi-Fan; Su, K W; Huang, K F; Chen, Y F

    2012-09-24

    We experimentally confirm that diamond surface cooling can significantly enhance the output performance of a sub-nanosecond diode-end-pumped passively Q-switched Yb:YAG laser. It is found that the pulse energy obtained with diamond cooling is approximately 1.5 times greater than that obtained without diamond cooling, where a Cr(4+):YAG absorber with the initial transmission of 84% is employed. Furthermore, the standard deviation of the pulse amplitude peak-to-peak fluctuation is found to be approximately 3 times lower than that measured without diamond cooling. Under a pump power of 3.9 W, the passively Q-switched Yb:YAG laser can generate a pulse train of 3.3 kHz repetition rate with a pulse energy of 287 μJ and with a pulse width of 650 ps.

  18. Functional Variants at the 11q13 Risk Locus for Breast Cancer Regulate Cyclin D1 Expression through Long-Range Enhancers

    Science.gov (United States)

    French, Juliet D.; Ghoussaini, Maya; Edwards, Stacey L.; Meyer, Kerstin B.; Michailidou, Kyriaki; Ahmed, Shahana; Khan, Sofia; Maranian, Mel J.; O’Reilly, Martin; Hillman, Kristine M.; Betts, Joshua A.; Carroll, Thomas; Bailey, Peter J.; Dicks, Ed; Beesley, Jonathan; Tyrer, Jonathan; Maia, Ana-Teresa; Beck, Andrew; Knoblauch, Nicholas W.; Chen, Constance; Kraft, Peter; Barnes, Daniel; González-Neira, Anna; Alonso, M. Rosario; Herrero, Daniel; Tessier, Daniel C.; Vincent, Daniel; Bacot, Francois; Luccarini, Craig; Baynes, Caroline; Conroy, Don; Dennis, Joe; Bolla, Manjeet K.; Wang, Qin; Hopper, John L.; Southey, Melissa C.; Schmidt, Marjanka K.; Broeks, Annegien; Verhoef, Senno; Cornelissen, Sten; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Fasching, Peter A.; Loehberg, Christian R.; Ekici, Arif B.; Beckmann, Matthias W.; Peto, Julian; dos Santos Silva, Isabel; Johnson, Nichola; Aitken, Zoe; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Burwinkel, Barbara; Guénel, Pascal; Truong, Thérèse; Laurent-Puig, Pierre; Menegaux, Florence; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Milne, Roger L.; Zamora, M. Pilar; Arias Perez, Jose Ignacio; Benitez, Javier; Anton-Culver, Hoda; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Meindl, Alfons; Lichtner, Peter; Schmutzler, Rita K.; Engel, Christoph; Brauch, Hiltrud; Hamann, Ute; Justenhoven, Christina; Aaltonen, Kirsimari; Heikkilä, Päivi; Aittomäki, Kristiina; Blomqvist, Carl; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Sueta, Aiko; Bogdanova, Natalia V.; Antonenkova, Natalia N.; Dörk, Thilo; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Wu, Anna H.; Tseng, Chiu-chen; Van Den Berg, David; Stram, Daniel O.; Lambrechts, Diether; Peeters, Stephanie; Smeets, Ann; Floris, Giuseppe; Chang-Claude, Jenny; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Radice, Paolo; Peterlongo, Paolo; Bonanni, Bernardo; Sardella, Domenico; Couch, Fergus J.; Wang, Xianshu; Pankratz, Vernon S.; Lee, Adam; Giles, Graham G.; Severi, Gianluca; Baglietto, Laura; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Simard, Jacques; Goldberg, Mark S.; Labrèche, France; Dumont, Martine; Teo, Soo Hwang; Yip, Cheng Har; Ng, Char-Hong; Vithana, Eranga Nishanthie; Kristensen, Vessela; Zheng, Wei; Deming-Halverson, Sandra; Shrubsole, Martha; Long, Jirong; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Mulligan, Anna Marie; Devilee, Peter; Seynaeve, Caroline; García-Closas, Montserrat; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Czene, Kamila; Klevebring, Daniel; Schoof, Nils; Hooning, Maartje J.; Martens, John W.M.; Collée, J. Margriet; Tilanus-Linthorst, Madeleine; Hall, Per; Li, Jingmei; Liu, Jianjun; Humphreys, Keith; Shu, Xiao-Ou; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Cox, Angela; Balasubramanian, Sabapathy P.; Blot, William; Signorello, Lisa B.; Cai, Qiuyin; Pharoah, Paul D.P.; Healey, Catherine S.; Shah, Mitul; Pooley, Karen A.; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Hartman, Mikael; Miao, Hui; Sng, Jen-Hwei; Sim, Xueling; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Sangrajrang, Suleeporn; Gaborieau, Valerie; McKay, James; Toland, Amanda E.; Ambrosone, Christine B.; Yannoukakos, Drakoulis; Godwin, Andrew K.; Shen, Chen-Yang; Hsiung, Chia-Ni; Wu, Pei-Ei; Chen, Shou-Tung; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Schoemaker, Minouk J.; Ponder, Bruce A.J.; Nevanlinna, Heli; Brown, Melissa A.; Chenevix-Trench, Georgia; Easton, Douglas F.; Dunning, Alison M.

    2013-01-01

    Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for estrogen-receptor-positive tumors at 11q13. The strongest signal maps to a transcriptional enhancer element in which the G allele of the best candidate causative variant rs554219 increases risk of breast cancer, reduces both binding of ELK4 transcription factor and luciferase activity in reporter assays, and may be associated with low cyclin D1 protein levels in tumors. Another candidate variant, rs78540526, lies in the same enhancer element. Risk association signal 2, rs75915166, creates a GATA3 binding site within a silencer element. Chromatin conformation studies demonstrate that these enhancer and silencer elements interact with each other and with their likely target gene, CCND1. PMID:23540573

  19. The Krüppel-like Factor 15 as a Molecular Link between Myogenic Factors and a Chromosome 4q Transcriptional Enhancer Implicated in Facioscapulohumeral Dystrophy*

    Science.gov (United States)

    Dmitriev, Petr; Petrov, Andrei; Ansseau, Eugenie; Stankevicins, Luiza; Charron, Sébastien; Kim, Elena; Bos, Tomas Jan; Robert, Thomas; Turki, Ahmed; Coppée, Frédérique; Belayew, Alexandra; Lazar, Vladimir; Carnac, Gilles; Laoudj, Dalila; Lipinski, Marc; Vassetzky, Yegor S.

    2011-01-01

    Facioscapulohumeral muscular dystrophy (FSHD), a dominant hereditary disease with a prevalence of 7 per 100,000 individuals, is associated with a partial deletion in the subtelomeric D4Z4 repeat array on chromosome 4q. The D4Z4 repeat contains a strong transcriptional enhancer that activates promoters of several FSHD-related genes. We report here that the enhancer within the D4Z4 repeat binds the Krüppel-like factor KLF15. KLF15 was found to be up-regulated during myogenic differentiation induced by serum starvation or by overexpression of the myogenic differentiation factor MYOD. When overexpressed, KLF15 activated the D4Z4 enhancer and led to overexpression of DUX4c (Double homeobox 4, centromeric) and FRG2 (FSHD region gene 2) genes, whereas its silencing caused inactivation of the D4Z4 enhancer. In immortalized human myoblasts, the D4Z4 enhancer was activated by the myogenic factor MYOD, an effect that was abolished upon KLF15 silencing or when the KLF15-binding sites within the D4Z4 enhancer were mutated, indicating that the myogenesis-related activation of the D4Z4 enhancer was mediated by KLF15. KLF15 and several myogenesis-related factors were found to be expressed at higher levels in myoblasts, myotubes, and muscle biopsies from FSHD patients than in healthy controls. We propose that KLF15 serves as a molecular link between myogenic factors and the activity of the D4Z4 enhancer, and it thus contributes to the overexpression of the DUX4c and FRG2 genes during normal myogenic differentiation and in FSHD. PMID:21937448

  20. Q fever

    Science.gov (United States)

    ... Coxiella burnetii . These bacteria can infect: Sheep Goats Cattle Dogs Cats Birds Rodents Ticks Infected animals shed ... The main treatment for Q fever is antibiotics. For early-stage Q ... If you have the infection for more than 6 months, it is called ...

  1. Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression

    Science.gov (United States)

    Darabi, Hatef; McCue, Karen; Beesley, Jonathan; Michailidou, Kyriaki; Nord, Silje; Kar, Siddhartha; Humphreys, Keith; Thompson, Deborah; Ghoussaini, Maya; Bolla, Manjeet K.; Dennis, Joe; Wang, Qin; Canisius, Sander; Scott, Christopher G.; Apicella, Carmel; Hopper, John L.; Southey, Melissa C.; Stone, Jennifer; Broeks, Annegien; Schmidt, Marjanka K.; Scott, Rodney J.; Lophatananon, Artitaya; Muir, Kenneth; Beckmann, Matthias W.; Ekici, Arif B.; Fasching, Peter A.; Heusinger, Katharina; dos-Santos-Silva, Isabel; Peto, Julian; Tomlinson, Ian; Sawyer, Elinor J.; Burwinkel, Barbara; Marme, Frederik; Guénel, Pascal; Truong, Thérèse; Bojesen, Stig E.; Flyger, Henrik; Benitez, Javier; González-Neira, Anna; Anton-Culver, Hoda; Neuhausen, Susan L.; Arndt, Volker; Brenner, Hermann; Engel, Christoph; Meindl, Alfons; Schmutzler, Rita K.; Arnold, Norbert; Brauch, Hiltrud; Hamann, Ute; Chang-Claude, Jenny; Khan, Sofia; Nevanlinna, Heli; Ito, Hidemi; Matsuo, Keitaro; Bogdanova, Natalia V.; Dörk, Thilo; Lindblom, Annika; Margolin, Sara; Kosma, Veli-Matti; Mannermaa, Arto; Tseng, Chiu-chen; Wu, Anna H.; Floris, Giuseppe; Lambrechts, Diether; Rudolph, Anja; Peterlongo, Paolo; Radice, Paolo; Couch, Fergus J.; Vachon, Celine; Giles, Graham G.; McLean, Catriona; Milne, Roger L.; Dugué, Pierre-Antoine; Haiman, Christopher A.; Maskarinec, Gertraud; Woolcott, Christy; Henderson, Brian E.; Goldberg, Mark S.; Simard, Jacques; Teo, Soo H.; Mariapun, Shivaani; Helland, Åslaug; Haakensen, Vilde; Zheng, Wei; Beeghly-Fadiel, Alicia; Tamimi, Rulla; Jukkola-Vuorinen, Arja; Winqvist, Robert; Andrulis, Irene L.; Knight, Julia A.; Devilee, Peter; Tollenaar, Robert A.E.M.; Figueroa, Jonine; García-Closas, Montserrat; Czene, Kamila; Hooning, Maartje J.; Tilanus-Linthorst, Madeleine; Li, Jingmei; Gao, Yu-Tang; Shu, Xiao-Ou; Cox, Angela; Cross, Simon S.; Luben, Robert; Khaw, Kay-Tee; Choi, Ji-Yeob; Kang, Daehee; Hartman, Mikael; Lim, Wei Yen; Kabisch, Maria; Torres, Diana; Jakubowska, Anna; Lubinski, Jan; McKay, James; Sangrajrang, Suleeporn; Toland, Amanda E.; Yannoukakos, Drakoulis; Shen, Chen-Yang; Yu, Jyh-Cherng; Ziogas, Argyrios; Schoemaker, Minouk J.; Swerdlow, Anthony; Borresen-Dale, Anne-Lise; Kristensen, Vessela; French, Juliet D.; Edwards, Stacey L.; Dunning, Alison M.; Easton, Douglas F.; Hall, Per; Chenevix-Trench, Georgia

    2015-01-01

    Genome-wide association studies have identified SNPs near ZNF365 at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association signal by genotyping 428 SNPs across the region in 89,050 European and 12,893 Asian case and control subjects from the Breast Cancer Association Consortium. We identified four independent sets of correlated, highly trait-associated variants (iCHAVs), three of which were located within ZNF365. The most strongly risk-associated SNP, rs10995201 in iCHAV1, showed clear evidence of association with both estrogen receptor (ER)-positive (OR = 0.85 [0.82–0.88]) and ER-negative (OR = 0.87 [0.82–0.91]) disease, and was also the SNP most strongly associated with percent mammographic density. iCHAV2 (lead SNP, chr10: 64,258,684:D) and iCHAV3 (lead SNP, rs7922449) were also associated with ER-positive (OR = 0.93 [0.91–0.95] and OR = 1.06 [1.03–1.09]) and ER-negative (OR = 0.95 [0.91–0.98] and OR = 1.08 [1.04–1.13]) disease. There was weaker evidence for iCHAV4, located 5′ of ADO, associated only with ER-positive breast cancer (OR = 0.93 [0.90–0.96]). We found 12, 17, 18, and 2 candidate causal SNPs for breast cancer in iCHAVs 1–4, respectively. Chromosome conformation capture analysis showed that iCHAV2 interacts with the ZNF365 and NRBF2 (more than 600 kb away) promoters in normal and cancerous breast epithelial cells. Luciferase assays did not identify SNPs that affect transactivation of ZNF365, but identified a protective haplotype in iCHAV2, associated with silencing of the NRBF2 promoter, implicating this gene in the etiology of breast cancer. PMID:26073781

  2. An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression

    DEFF Research Database (Denmark)

    Wyszynski, Asaf; Hong, Chi-Chen; Lam, Kristin

    2016-01-01

    Breast cancer is the most diagnosed malignancy and the second leading cause of cancer mortality in females. Previous association studies have identified variants on 2q35 associated with the risk of breast cancer. To identify functional susceptibility loci for breast cancer, we interrogated the 2q...

  3. Co-enzyme Q10 and acetyl salicylic acid enhance Hsp70 expression in primary chicken myocardial cells to protect the cells during heat stress.

    Science.gov (United States)

    Xu, Jiao; Tang, Shu; Yin, Bin; Sun, Jiarui; Song, Erbao; Bao, Endong

    2017-05-11

    We investigated the effects of co-enzyme Q10 (Q10) and acetyl salicylic acid (ASA) on expression of Hsp70 in the protection of primary chicken myocardial cells during heat stress. Western blot analysis showed that Q10 and ASA accelerated the induction of Hsp70 when chicken myocardial cells were exposed to hyperthermia. In the absence of heat stress, however, neither Q10 nor ASA are able to upregulate Hsp70 expression. Analysis of enzymes that respond to cellular damage and pathological examination revealed that ectopic expression of ASA and Q10 alleviate cellular damage during heat stress. Quantification of heat shock factors (HSF) indicated that treatment of ASA increased the expression of HSF-1 and HSF-3 during heat stress. Treatment with Q10 resulted in the elevation of HSF-1 expression. Expression of HSF-2 and HSF-4 was not affected by ASA or Q10. Subcellular distribution analysis of HSF-1 and HSF-3 showed that in response to heat stress ASA promoted nuclear translocation of HSF-1 and HSF-3, while Q10 promoted only HSF-1 nuclear translocation. Chromatin immunoprecipitation (ChIP) analysis indicated that HSF-1 occupies the Hsp70 promoter in chicken primary myocardial cells during heat stress and under normal conditions, while HSF-3 occupies the Hsp70 promoter only during heat stress. Real-time PCR analysis revealed that ASA induces HSF-1 and HSF-3 binding to Hsp70 HSE, while Q10 only induces HSF1 binding to Hsp70 HSE, in agreement with the impact of HSF1 and HSF3 silencing on Hsp70 expression. These data demonstrate that ASA and Q10 both induce the expression of Hsp70 to protect chicken primary myocardial cells during heat stress, but through distinct pathways.

  4. Coenzyme Q10 enhances the anticonvulsant effect of phenytoin in pilocarpine-induced seizures in rats and ameliorates phenytoin-induced cognitive impairment and oxidative stress.

    Science.gov (United States)

    Tawfik, Mona K

    2011-12-01

    Conventional antiepileptic drugs fail to adequately control seizures and predispose to cognitive impairment and oxidative stress with chronic usage in a significant proportion of patients with epilepsy. Coenzyme Q10 (CoQ10), an antioxidant compound, exhibits a wide range of therapeutic effects that are attributed to its potent antioxidant capacity. To evaluate the neuroprotective effects of CoQ10 in rats against the observed oxidative stress during seizures induced by pilocarpine, and to study its interactions with the conventional antiepileptic drug phenytoin, two experiments were performed. Experiment 1 was conducted to test the effect of phenytoin, CoQ10, or both on seizure severity and oxidative markers in the pilocarpine model of epilepsy. Experiment 2 was conducted to test the effect of 2 weeks of chronic treatment with phenytoin, CoQ10, or both on oxidative markers and behavioral tests in rats. Overall, CoQ10 reduced the severity of pilocarpine-induced seizures and the severity of oxidative stress. Moreover, it potentiated the antiepileptic effects afforded by phenytoin treatment, with the potential safety and efficacy in ameliorating oxidative stress and cognitive impairment caused by chronic phenytoin therapy. Our findings strongly suggest that CoQ10 can be considered a safe and effective adjuvant to phenytoin therapy in epilepsy both to ameliorate seizure severity and to protect against seizure-induced oxidative damage by reducing the cognitive impairment and oxidative stress associated with chronic use of phenytoin.

  5. Addition of vasopressin synthetic analogue [V(4)Q(5)]dDAVP to standard chemotherapy enhances tumour growth inhibition and impairs metastatic spread in aggressive breast tumour models.

    Science.gov (United States)

    Garona, Juan; Pifano, Marina; Pastrian, Maria B; Gomez, Daniel E; Ripoll, Giselle V; Alonso, Daniel F

    2016-08-01

    [V(4)Q(5)]dDAVP is a novel 2nd generation vasopressin analogue with robust antitumour activity against metastatic breast cancer. We recently reported that, by acting on vasopressin V2r membrane receptor present in tumour cells and microvascular endothelium, [V(4)Q(5)]dDAVP inhibits angiogenesis and metastatic progression of the disease without overt toxicity. Despite chemotherapy remaining as a primary therapeutic option for aggressive breast cancer, its use is limited by low selectivity and associated adverse effects. In this regard, we evaluated potential combinational benefits by adding [V(4)Q(5)]dDAVP to standard-of-care chemotherapy. In vitro, combination of [V(4)Q(5)]dDAVP with sub-IC50 concentrations of paclitaxel or carmustine resulted in a cooperative inhibition of breast cancer cell growth in comparison to single-agent therapy. In vivo antitumour efficacy of [V(4)Q(5)]dDAVP addition to chemotherapy was first evaluated using the triple-negative MDA-MB-231 breast cancer xenograft model. Tumour-bearing mice were treated with i.v. injections of [V(4)Q(5)]dDAVP (0.3 μg/kg, thrice weekly) in combination with weekly cycles of paclitaxel (10 mg/kg i.p.). After 6 weeks of treatment, combination regimen resulted in greater tumour growth inhibition compared to monotherapy. [V(4)Q(5)]dDAVP addition was also associated with reduction of local aggressiveness, and impairment of tumour invasion and infiltration of the skin. Benefits of combined therapy were confirmed in the hormone-independent and metastatic F3II breast cancer model by combining [V(4)Q(5)]dDAVP with carmustine (25 mg/kg i.p.). Interestingly, [V(4)Q(5)]dDAVP plus cytotoxic agents severely impaired colony forming ability of tumour cells and inhibited breast cancer metastasis to lung. The present study shows that [V(4)Q(5)]dDAVP may complement conventional chemotherapy by modulating metastatic progression and early stages of microtumour establishment, and thus supports further preclinical testing of

  6. Activation of human microglia by fibrillar prion protein-related peptides is enhanced by amyloid-associated factors SAP and C1q

    NARCIS (Netherlands)

    Veerhuis, R.; Boshuizen, R.S.; Morbin, M.; Mazzoleni, G.; Hoozemans, J.J.; Langedijk, J.P.; Tagliavini, F.; Langeveld, J.P.M.; Eikelenboom, P.

    2005-01-01

    Complement activation products C1q and C3d, serum amyloid P component (SAP) and activated glial cells accumulate in amyloid deposits of conformationally changed prion protein (PrPSc) in Creutzfeldt¿Jakob disease, Gerstmann¿Sträussler¿Scheinker disease and scrapie-infected mouse brain. Biological pro

  7. Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression

    DEFF Research Database (Denmark)

    Darabi, Hatef; McCue, Karen; Beesley, Jonathan

    2015-01-01

    Genome-wide association studies have identified SNPs near ZNF365 at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association signal by genotyping 428 SNPs across the region in 89,050 European and 12,...

  8. Enhancement of muscular performance by a coformulation of propionyl-L-carnitine, coenzyme Q10, nicotinamide, riboflavin and pantothenic acid in the rat.

    Science.gov (United States)

    Vargiu, Romina; Licheri, Donatella; Carcassi, Anna Maria; Naimi, Silvia; Collu, Maria; Littarru, Gian Paolo; Mancinelli, Rino

    2002-06-01

    A coformulation of essential factors, i.e. propionyl-L-carnitine (PLC), coenzyme Q10 (CoQ10), nicotinamide (NAM), riboflavin and pantothenic acid, was administered orally to Wistar rats for 7 weeks and its efficacy was tested through in vivo and in vitro techniques in improving motor functions of striated, cardiac and smooth musculature of the rat. In vivo experiments showed that long-term supplementation significantly improved horizontal locomotor activity by about 19% in male and 26% in female rats. Maximum values of shortening velocity, work and power were significantly increased (PWork was the most affected parameter and it increased by 160% in smooth muscle from treated animals. The present results indicate that supplementation with the combination of the above mentioned substances elicits positive functional changes on motor performance of skeletal, cardiac and smooth muscle of the rat.

  9. Amitriptyline improves motor function via enhanced neurotrophin signaling and mitochondrial functions in the murine N171-82Q Huntington disease model.

    Science.gov (United States)

    Cong, Wei-Na; Chadwick, Wayne; Wang, Rui; Daimon, Caitlin M; Cai, Huan; Amma, Jennifer; Wood, William H; Becker, Kevin G; Martin, Bronwen; Maudsley, Stuart

    2015-01-30

    Huntington disease (HD) is a neurodegenerative disorder characterized by progressive motor impairment and cognitive alterations. Hereditary HD is primarily caused by the expansion of a CAG trinucleotide repeat in the huntingtin (Htt) gene, which results in the production of mutant huntingtin protein (mHTT) with an expanded amino-terminal polyglutamine (poly(Q)) stretch. Besides pathological mHTT aggregation, reduced brain-derived neurotrophic factor (BDNF) levels, impaired neurotrophin signaling, and compromised mitochondrial functions also contribute to the deleterious progressive etiology of HD. As a well tolerated Food and Drug Administration-approved antidepressant, amitriptyline (AMI) has shown efficacy in treating neurodegenerative murine models via potentiation of BDNF levels and amelioration of alterations in neurotrophin signaling pathways. In this study, we observed profound improvements in the motor coordination of AMI-treated N171-82Q HD model mice. The beneficial effects of AMI treatment were associated with its ability to reduce mHTT aggregation, potentiation of the BDNF-TrkB signaling system, and support of mitochondrial integrity and functionality. Our study not only provides preclinical evidence for the therapeutic potency of AMI in treating HD, but it also represents an important example of the usefulness of additional pharmacogenomic profiling of pre-existing drugs for novel therapeutic effects with often intractable pathological scenarios. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  10. Familial hemiplegic migraine CaV2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain

    Directory of Open Access Journals (Sweden)

    Nair Asha

    2010-08-01

    Full Text Available Abstract Background The R192Q mutation of the CACNA1A gene, encoding for the α1 subunit of voltage-gated P/Q Ca2+ channels (Cav2.1, is associated with familial hemiplegic migraine-1. We investigated whether this gain-of-function mutation changed the structure and function of trigeminal neuron P2X3 receptors that are thought to be important contributors to migraine pain. Results Using in vitro trigeminal sensory neurons of a mouse genetic model knockin for the CACNA1A R192Q mutation, we performed patch clamp recording and intracellular Ca2+ imaging that showed how these knockin ganglion neurons generated P2X3 receptor-mediated responses significantly larger than wt neurons. These enhanced effects were reversed by the Cav2.1 blocker ω-agatoxin. We, thus, explored intracellular signalling dependent on kinases and phosphatases to understand the molecular regulation of P2X3 receptors of knockin neurons. In such cells we observed strong activation of CaMKII reversed by ω-agatoxin treatment. The CaMKII inhibitor KN-93 blocked CaMKII phosphorylation and the hyperesponsive P2X3 phenotype. Although no significant difference in membrane expression of knockin receptors was found, serine phosphorylation of knockin P2X3 receptors was constitutively decreased and restored by KN-93. No change in threonine or tyrosine phosphorylation was detected. Finally, pharmacological inhibitors of the phosphatase calcineurin normalized the enhanced P2X3 receptor responses of knockin neurons and increased their serine phosphorylation. Conclusions The present results suggest that the CACNA1A mutation conferred a novel molecular phenotype to P2X3 receptors of trigeminal ganglion neurons via CaMKII-dependent activation of calcineurin that selectively impaired the serine phosphorylation state of such receptors, thus potentiating their effects in transducing trigeminal nociception.

  11. RECENT ADVANCES IN THE 5Q- SYNDROME

    Directory of Open Access Journals (Sweden)

    Andrea Pellagatti

    2015-05-01

    Full Text Available The 5q- syndrome is the most distinct of the myelodysplastic syndromes (MDS and patients with this disorder have a deletion of chromosome 5q [del(5q] as the sole karyotypic abnormality. Several genes mapping to the commonly deleted region of the 5q- syndrome have been implicated in disease pathogenesis in recent years. Haploinsufficiency of the ribosomal gene RPS14 has been shown to cause the erythroid defect in the 5q- syndrome. Loss of the microRNA genes miR-145 and miR-146a has been associated with the thrombocytosis observed in 5q- syndrome patients. Haploinsufficiency of CSNK1A1 leads to hematopoietic stem cell expansion in mice and may play a role in the initial clonal expansion in patients with 5q- syndrome. Moreover, a subset of patients harbor mutation of the remaining CSNK1A1 allele. Mouse models of the 5q- syndrome, which recapitulate the key features of the human disease, indicate that a p53-dependent mechanism underlies the pathophysiology of this disorder. Importantly, activation of p53 has been demonstrated in the human 5q- syndrome. Recurrent TP53 mutations have been associated with an increased risk of disease evolution and with decreased response to the drug lenalidomide in del(5q MDS patients. Potential new therapeutic agents for del(5q MDS include the translation enhancer L-leucine.

  12. Skew cyclic codes over F_q+uF_q+vF_q+uvF_q

    Directory of Open Access Journals (Sweden)

    Ting Yao

    2015-09-01

    Full Text Available In this paper, we study skew cyclic codes over the ring $R=F_q+uF_q+vF_q+uvF_q$, where $u^{2}=u,v^{2}=v,uv=vu$, $q=p^{m}$ and $p$ is an odd prime. We investigate the structural properties of skew cyclic codes over $R$ through a decomposition theorem. Furthermore, we give a formula for the number of skew cyclic codes of length $n$ over $R.$

  13. Defining Z in Q

    CERN Document Server

    Koenigsmann, Jochen

    2010-01-01

    We show that ${\\mathbb Z}$ is definable in ${\\mathbb Q}$ by a universal first-order formula in the language of rings. We also present an $\\forall\\exists$-formula for ${\\mathbb Z}$ in ${\\mathbb Q}$ with just one universal quantifier. We exhibit new diophantine subsets of ${\\mathbb Q}$ like the set of non-squares or the complement of the image of the norm map under a quadratic extension. Finally, we show that there is no existential formula for ${\\mathbb Z}$ in ${\\mathbb Q}$, provided one assumes a strong variant of the Bombieri-Lang Conjecture for varieties over ${\\mathbb Q}$ with many ${\\mathbb Q}$-rational points.

  14. Enhanced mechanical properties of an Al–Si–Cu–Mg alloy at 300 °C: Effects of Mg and the Q-precipitate phase

    Energy Technology Data Exchange (ETDEWEB)

    Farkoosh, A.R., E-mail: amir.rezaeifarkoosh@mail.mcgill.ca; Pekguleryuz, M., E-mail: mihriban.pekguleryuz@mcgill.ca

    2015-01-05

    Strategies to improve the strength of Al–Si alloys at elevated temperatures can follow two routes: (i) improving the age-hardening behavior and/or (ii) producing effective dispersoid strengthening. In this study, the influence of Mg (in the range of 0.3–0.7 wt%) on the precipitation characteristics and mechanical properties of the Al–7Si–0.5Cu–(Mg) alloy was investigated. Thermodynamic calculations were performed via the CALPHAD method which showed that Q-Al{sub 5}Mg{sub 8}Cu{sub 2}Si{sub 6} is the main thermodynamically stable precipitate at 300 °C. The calculations were validated by transmission electron microscopy and differential scanning calorimetry analyses. Increasing the Mg level from 0.3 wt% to the maximum solubility limit of ∼0.5 wt% increased the amount of the Q-Al{sub 5}Mg{sub 8}Cu{sub 2}Si{sub 6} precipitates at 300 °C by ∼60 wt% and significantly improved the tensile strength and creep resistance at the expense of some ductility. Mg in excess of the solubility limit was seen to remain within the microstructure in the form of the large π-Al{sub 8}FeMg{sub 3}Si{sub 6} and β-Mg{sub 2}Si intermetallics after solution treatment at 530 °C. Cracking of the brittle π-Al{sub 8}FeMg{sub 3}Si{sub 6} intermetallics during deformation was accounted for the decreased ductility of the alloys at high Mg levels. It is concluded that the Mg level can be increased to 0.5 wt% in the A–7Si–0.5Cu alloys to improve strength. However, for elevated temperature applications in which both strength and ductility are required (e.g. Diesel engine), modification of the π-Al{sub 8}FeMg{sub 3}Si{sub 6} intermetallics would be required to improve the ductility of the alloys with high Mg contents.

  15. Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus.

    Directory of Open Access Journals (Sweden)

    Clint L Miller

    Full Text Available Coronary heart disease (CHD is the leading cause of mortality in both developed and developing countries worldwide. Genome-wide association studies (GWAS have now identified 46 independent susceptibility loci for CHD, however, the biological and disease-relevant mechanisms for these associations remain elusive. The large-scale meta-analysis of GWAS recently identified in Caucasians a CHD-associated locus at chromosome 6q23.2, a region containing the transcription factor TCF21 gene. TCF21 (Capsulin/Pod1/Epicardin is a member of the basic-helix-loop-helix (bHLH transcription factor family, and regulates cell fate decisions and differentiation in the developing coronary vasculature. Herein, we characterize a cis-regulatory mechanism by which the lead polymorphism rs12190287 disrupts an atypical activator protein 1 (AP-1 element, as demonstrated by allele-specific transcriptional regulation, transcription factor binding, and chromatin organization, leading to altered TCF21 expression. Further, this element is shown to mediate signaling through platelet-derived growth factor receptor beta (PDGFR-β and Wilms tumor 1 (WT1 pathways. A second disease allele identified in East Asians also appears to disrupt an AP-1-like element. Thus, both disease-related growth factor and embryonic signaling pathways may regulate CHD risk through two independent alleles at TCF21.

  16. Q fever in Greenland

    DEFF Research Database (Denmark)

    Koch, Anders; Svendsen, Claus Bo; Christensen, Jens Jorgen

    2010-01-01

    We report a patient with Q fever endocarditis in a settlement in eastern Greenland (Isortoq, Ammassalik area). Likely animal sources include sled dogs and seals. Q fever may be underdiagnosed in Arctic areas but may also represent an emerging infection.......We report a patient with Q fever endocarditis in a settlement in eastern Greenland (Isortoq, Ammassalik area). Likely animal sources include sled dogs and seals. Q fever may be underdiagnosed in Arctic areas but may also represent an emerging infection....

  17. Q fever in Greenland

    DEFF Research Database (Denmark)

    Koch, Anders; Svendsen, Claus Bo; Christensen, Jens Jorgen

    2010-01-01

    We report a patient with Q fever endocarditis in a settlement in eastern Greenland (Isortoq, Ammassalik area). Likely animal sources include sled dogs and seals. Q fever may be underdiagnosed in Arctic areas but may also represent an emerging infection.......We report a patient with Q fever endocarditis in a settlement in eastern Greenland (Isortoq, Ammassalik area). Likely animal sources include sled dogs and seals. Q fever may be underdiagnosed in Arctic areas but may also represent an emerging infection....

  18. MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia.

    Science.gov (United States)

    Prange, K H M; Mandoli, A; Kuznetsova, T; Wang, S-Y; Sotoca, A M; Marneth, A E; van der Reijden, B A; Stunnenberg, H G; Martens, J H A

    2017-06-08

    In 11q23 leukemias, the N-terminal part of the mixed lineage leukemia (MLL) gene is fused to >60 different partner genes. In order to define a core set of MLL rearranged targets, we investigated the genome-wide binding of the MLL-AF9 and MLL-AF4 fusion proteins and associated epigenetic signatures in acute myeloid leukemia (AML) cell lines THP-1 and MV4-11. We uncovered both common as well as specific MLL-AF9 and MLL-AF4 target genes, which were all marked by H3K79me2, H3K27ac and H3K4me3. Apart from promoter binding, we also identified MLL-AF9 and MLL-AF4 binding at specific subsets of non-overlapping active distal regulatory elements. Despite this differential enhancer binding, MLL-AF9 and MLL-AF4 still direct a common gene program, which represents part of the RUNX1 gene program and constitutes of CD34(+) and monocyte-specific genes. Comparing these data sets identified several zinc finger transcription factors (TFs) as potential MLL-AF9 co-regulators. Together, these results suggest that MLL fusions collaborate with specific subsets of TFs to deregulate the RUNX1 gene program in 11q23 AMLs.

  19. Q-instantons

    NARCIS (Netherlands)

    Bergshoeff, E. A.; Hartong, J.; Ploegh, A.; Sorokin, D.

    2008-01-01

    We construct the half-supersymmetric instanton solutions that are electric-magnetically dual to the recently discussed half-supersymmetric Q7-branes. We call these instantons "Q-instantons". Whereas the D-instanton is most conveniently described using the RR axion chi and the dilaton phi, the Q-inst

  20. 左卡尼汀(而非辅酶 Q10)提高阿托伐他汀在切除卵巢的老鼠的抗骨质疏松作用%L-Carnitine, but not coenzyme Q10, enhances the anti-osteoporotic effect of atorvastatin in ovariectomized rats

    Institute of Scientific and Technical Information of China (English)

    Hussam A S MURAD

    2016-01-01

    Objective: Statins’ therapy in osteoporosis can aggravate muscle damage. This study was designed to assess which agent,L-carnitine or coenzyme Q10, could enhance the anti-osteoporotic effect of atorvastatin while antagonizing myopathy in ovariectomized rats. Methods: Forty-eight female Sprague Dawley rats were used; forty rats were ovariectomized while eight were sham-operated. Eight weeks post-ovariectomy, rats were divided into ovariectomized-untreated group and four ovariectomized-treated groups (n=8) which received by gavage (mg/(kg·d), for 8 weeks) 17β-estradiol (0.1), atorvastatin (50), atorvastatin (50)+L-carnitine (100), or atorvastatin (50)+coenzyme Q10 (20). At the end of therapy, bone mineral density (BMD), bone mineral content (BMC), and serum levels of bone metabolic markers (BMMs) and creatine kinase (CK) were measured. Femurs were used for studying the breaking strength and histopathological changes. Results: Treatment with atorvastatin+L-carnitine restored BMD, BMC, and bone strength to near normal levels. Estrogen therapy restored BMD and BMC to near normal levels, but failed to increase bone strength. Although atorvastatin and atorvastatin+coenzyme Q10 improved BMD, BMC, and bone strength, they failed to restore levels to normal. Al treatments decreased BMMs and improved histopathological changes maximaly with atorvastatin+L-carnitine which restored levels to near normal. Atorvastatin aggravated the ovariectomy-induced increase in CK level while estrogen, atorvastatin+L-carnitine, and atorvastatin+coenzyme Q10 decreased its level mainly with atorvastatin+L-carnitine which restored the level to near normal. Conclusions: Co-administrationofL-carnitine, but not coenzyme Q10, enhances the anti-osteoporotic effect of atorvastatin while an-tagonizing myopathy in ovariectomized rats. This could be valuable in treatment of osteoporotic patients. However, further confirmatory studies are needed.%目的:他汀类药物在治疗骨质疏松症时会

  1. Enhancement of DNA repair using topical T4 endonuclease V does not inhibit melanoma formation in Cdk4(R24C/R24C)/Tyr-Nras(Q61K) mice following neonatal UVR.

    Science.gov (United States)

    Hacker, Elke; Muller, H Konrad; Hayward, Nicholas; Fahey, Paul; Walker, Graeme

    2010-02-01

    To further investigate the use of DNA repair-enhancing agents for skin cancer prevention, we treated Cdk4(R24C/R24C)/Nras(Q61K) mice topically with the T4 endonuclease V DNA repair enzyme (known as Dimericine) immediately prior to neonatal ultraviolet radiation (UVR) exposure, which has a powerful effect in exacerbating melanoma development in the mouse model. Dimericine has been shown to reduce the incidence of basal-cell and squamous cell carcinoma. Unexpectedly, we saw no difference in penetrance or age of onset of melanoma after neonatal UVR between Dimericine-treated and control animals, although the drug reduced DNA damage and cellular proliferation in the skin. Interestingly, epidermal melanocytes removed cyclobutane pyrimidine dimers (CPDs) more efficiently than surrounding keratinocytes. Our study indicates that neonatal UVR-initiated melanomas may be driven by mechanisms other than solely that of a large CPD load and/or their inefficient repair. This is further suggestive of different mechanisms by which UVR may enhance the transformation of keratinocytes and melanocytes.

  2. Q-tubes, Q-rings and Q-crusts

    CERN Document Server

    Sakai, Nobuyuki; Nakao, Ken-ichi

    2010-01-01

    We re-analyse scalar field theories which allow Q-ball solutions. We find new types of non-topological solitons: tube-shaped in SO(2) models, ring-shaped in SO(3) models, and crust-shaped in SO(3)\\times U(1) models. Although their field configurations are analogous to cosmic global strings or global monopoles, their gravitational mass are finite without gauge fields.

  3. Finite q-oscillator

    Energy Technology Data Exchange (ETDEWEB)

    Atakishiyev, Natig M [Centro de Ciencias FIsicas, UNAM, Apartado Postal 48-3, 62251 Cuernavaca, Morelos (Mexico); Klimyk, Anatoliy U [Centro de Ciencias FIsicas, UNAM, Apartado Postal 48-3, 62251 Cuernavaca, Morelos (Mexico); Wolf, Kurt Bernardo [Centro de Ciencias FIsicas, UNAM, Apartado Postal 48-3, 62251 Cuernavaca, Morelos (Mexico)

    2004-05-28

    The finite q-oscillator is a model that obeys the dynamics of the harmonic oscillator, with the operators of position, momentum and Hamiltonian being functions of elements of the q-algebra su{sub q}(2). The spectrum of position in this discrete system, in a fixed representation j, consists of 2j + 1 'sensor'-points x{sub s} = 1/2 [2s]{sub q}, s element of {l_brace}-j, -j+1, ..., j{r_brace}, and similarly for the momentum observable. The spectrum of energies is finite and equally spaced, so the system supports coherent states. The wavefunctions involve dual q-Kravchuk polynomials, which are solutions to a finite-difference Schroedinger equation. Time evolution (times a phase) defines the fractional Fourier-q-Kravchuk transform. In the classical limit as q {yields} 1 we recover the finite oscillator Lie algebra, the N = 2j {yields} {infinity} limit returns the Macfarlane-Biedenharn q-oscillator and both limits contract the generators to the standard quantum-mechanical harmonic oscillator.

  4. Double Q-learning

    NARCIS (Netherlands)

    Hasselt, H. van

    2010-01-01

    In some stochastic environments the well-known reinforcement learning algorithm Q-learning performs very poorly. This poor performance is caused by large overestimations of action values, which result from a positive bias that is introduced because Q-learning uses the maximum action value as an appr

  5. 22q11-deletionssyndrom

    DEFF Research Database (Denmark)

    Olesen, Charlotte; Agergaard, Peter; Boers, Maria

    2010-01-01

    22q11 deletion syndrome (formerly named CATCH22, DiGeorge, Velo-Cardio-Facial, Caylor, Kinouchi and Shprintzen syndrome) occurs in approximately 1/2000 to 4000 children. The genetic lesion is remarkably uniform, occurring mainly as 3 or 1.5 MB deletions in the 22q11.2 region. However, the clinical...

  6. RecQ Helicases

    DEFF Research Database (Denmark)

    Larsen, Nicolai Balle; Hickson, Ian D

    2013-01-01

    The RecQ family of DNA helicases is highly conserved throughout -evolution, and is important for the maintenance of genome stability. In humans, five RecQ family members have been identified: BLM, WRN, RECQ4, RECQ1 and RECQ5. Defects in three of these give rise to Bloom's syndrome (BLM), Werner...

  7. Partial deletion 11q

    DEFF Research Database (Denmark)

    Hertz, Jens Michael; Tommerup, N; Sørensen, F B;

    1995-01-01

    We describe the cytogenetic findings and the dysmorphic features in a stillborn girl with a large de novo terminal deletion of the long arm of chromosome 11. The karyotype was 46,XX,del(11)(q21qter). By reviewing previous reports of deletion 11q, we found that cleft lip and palate are most...

  8. Estimation of Q factors from reflection seismic data for a band-limited and stabilized inverse Q filter driven by an average-Q model

    Science.gov (United States)

    Chen, Zengbao; Chen, Xiaohong; Wang, Yanghua; Li, Jingye

    2014-02-01

    Reliable Q estimation is desirable for model-based inverse Q filtering to improve seismic resolution. On the one hand, conventional methods estimate Q from the amplitude spectra or frequency variations of individual wavelets at different depth (or time) levels, which is vulnerable to the effects of spectral interference and ambient noise. On the other hand, most inverse Q filtering algorithms are sensitive to noise, in order not to boost them, sometimes at the expense of degrading compensation effect. In this paper, the average-Q values are obtained from reflection seismic data based on the Gabor transform spectrum of a seismic trace. We transform the 2-D time-variant frequency spectrum into the 1-D spectrum, and then estimate the average-Q values based on the amplitude attenuation and compensation functions, respectively. Driven by the estimated average-Q model, we also develop a modified inverse Q filtering algorithm by incorporating a time-variant bandpass filter (TVBF), whose high cut off frequency follows a hyperbola along the traveltime from a specified time. Finally, we test this modified inverse Q filtering algorithm on synthetic data and perform the Q estimation procedure on a real reflection seismic data, followed by applying the modified inverse Q filtering algorithm. The synthetic data test and the real data example demonstrate that the algorithm driven by average-Q model may enhance the seismic resolution, without degrading the signal-to-noise ratio.

  9. Finite q-oscillator

    Science.gov (United States)

    Atakishiyev, Natig M.; Klimyk, Anatoliy U.; Wolf, Kurt Bernardo

    2004-05-01

    The finite q-oscillator is a model that obeys the dynamics of the harmonic oscillator, with the operators of position, momentum and Hamiltonian being functions of elements of the q-algebra suq(2). The spectrum of position in this discrete system, in a fixed representation j, consists of 2j + 1 'sensor'-points x_s={\\case12}[2s]_q, s\\in\\{-j,-j+1,\\ldots,j\\} , and similarly for the momentum observable. The spectrum of energies is finite and equally spaced, so the system supports coherent states. The wavefunctions involve dual q-Kravchuk polynomials, which are solutions to a finite-difference Schrödinger equation. Time evolution (times a phase) defines the fractional Fourier-q-Kravchuk transform. In the classical limit as q rarr 1 we recover the finite oscillator Lie algebra, the N = 2j rarr infin limit returns the Macfarlane-Biedenharn q-oscillator and both limits contract the generators to the standard quantum-mechanical harmonic oscillator.

  10. Compact Q-balls

    CERN Document Server

    Bazeia, D; Marques, M A; Menezes, R; da Rocha, R

    2016-01-01

    In this work we deal with non-topological solutions of the Q-ball type in two space-time dimensions, in models described by a single complex scalar field that engenders global symmetry. The main novelty is the presence of stable Q-balls solutions that live in a compact interval of the real line and appear from a family of models controlled by two distinct parameters. We find analytical solutions and study their charge and energy, and show how to control the parameters to make the Q-balls classically and quantum mechanically stable.

  11. Q fever - early

    Science.gov (United States)

    ... if untreated. Other complications can include: Bone infection ( osteomyelitis ) Brain infection ( encephalitis ) Liver infection (chronic hepatitis) Lung ... 2015:chap 190. Read More Encephalitis Endocarditis Flu Osteomyelitis Pneumonia - adults (community acquired) Q fever Tick bite ...

  12. Coenzyme Q10 (PDQ)

    Science.gov (United States)

    ... Liver Lung Cancer Lymphoma Pancreatic Cancer Prostate Cancer Skin Cancer Thyroid Cancer Uterine Cancer All Cancer Types ... healthy. The body also uses CoQ10 as an antioxidant . An antioxidant is a substance that protects cells ...

  13. FEMA Q3 Floodways

    Data.gov (United States)

    Minnesota Department of Natural Resources — The Q3 Flood Data are derived from the Flood Insurance Rate Maps (FIRMs) published by the Federal Emergency Management Agency (FEMA). The file is georeferenced to...

  14. The Spirituality of Q

    African Journals Online (AJOL)

    2015-07-01

    Jul 1, 2015 ... definitions have tended to emphasise the continuous nature of the experience under ... discussed in Q. Instead it is necessary to examine the material .... method – disclosure through the son who has privileged knowledge of ...

  15. Deletion (2)(q37)

    Energy Technology Data Exchange (ETDEWEB)

    Stratton, R.F.; Tolworthy, J.A.; Young, R.S. [South Texas Genetics Center, San Antonio, TX (United States)

    1994-06-01

    We report on a 5-month-old girl with widely spaced nipples, redundant nuchal skin, coarctation of the aorta, anal atresia with distal fistula, postnatal growth retardation, hypotonia, and sparse scalp hair. Initial clinical assessment suggested the diagnosis of Ullrich-Turner syndrome. Chromosome analysis showed a 46,XX,del(2)(q37) karyotype in peripheral lymphocytes. We compare her findings to those of other reported patients with terminal deletions of 2q. 8 refs., 2 figs., 1 tab.

  16. Emergence of Q Fever

    Directory of Open Access Journals (Sweden)

    E Angelakis

    2011-09-01

    Full Text Available Q fever is a worldwide zoonosis with many acute and chronic manifestations caused by the pathogen Coxiella burnetii. Farm animals and pets are the main reservoirs of infection, and transmission to human beings is mainly accomplished through inhalation of contaminated aerosols. Persons at greatest risk are those in contact with farm animals and include farmers, abattoir workers, and veterinarians. The organs most commonly affected during Q fever are the heart, the arteries, the bones and the liver. The most common clinical presentation is an influenza-like illness with varying degrees of pneumonia and hepatitis. Although acute disease is usually self-limiting, people do occasionally die from this condition. Endocarditis is the most serious and most frequent clinical presentation of chronic Q fever. Vascular infection is the second most frequent presentation of Q fever. The diagnosis of Q fever is based on a significant increase in serum antibody titers. The treatment is effective and well tolerated, but must be adapted to the acute or chronic pattern with the tetracyclines to be considered the mainstay of antibiotic therapy. For the treatment of Q fever during pregnancy the use of long-term cotrimoxazole therapy is proposed.

  17. q-ultraspherical polynomials for q a root of unity

    CERN Document Server

    Spiridonov, V P

    1996-01-01

    Properties of the q-ultraspherical polynomials for q being a primitive root of unity are derived using a formalism of the so_q(3) algebra. The orthogonality condition for these polynomials provides a new class of trigonometric identities representing discrete finite-dimensional analogs of q-beta integrals of Ramanujan.

  18. Q-MOHRA

    DEFF Research Database (Denmark)

    Kulkarni, Nandkumar P.; Prasad, Neeli R.; Prasad, Ramjee

    2016-01-01

    . This paper presents a novel heuristic routing algorithm known as QoS Assured Multi-Objective Hybrid Routing Algorithm (Q-MOHRA) for Heterogeneous WSN. Q-MOHRA takes into account the link (energy, hop count, link quality indicator etc.) and path (jitter) metrics for optimal path selection. The performance...... of Q-MOHRA is evaluated through intensive simulation and equated with Simple Hybrid Routing Protocol (SHRP) and Dynamic Multi-objective Routing Algorithm (DyMORA). The metrics such as Average Energy Consumption, Residual Energy, Packet Delivery Ratio, Jitter, and Normalized Routing Load are used...... for comparison. The performance of Q-MOHRA has been observed to outclass SHRP and DyMORA. It improves the Packet Delivery Ratio (PDR) by 13.72% as compared to SHRP and 28 % as compared to DyMORA. Q-MOHRA outperforms SHRP and DyMORA in terms of Average Energy Consumption (AEC) by a factor of 4.2 % and 2.3 %....

  19. Interacting Q-balls

    CERN Document Server

    Brihaye, Yves

    2007-01-01

    We construct explicit examples of new axially symmetric, non-spinning Q-ball solutions that have not been studied so far. These solutions can be interpreted as angular excitations of the fundamental Q-balls and are related to the spherical harmonics. Correspondingly, they have higher energy and their energy densities possess two local maxima on the positive z-axis. We also study two Q-balls interacting via a potential term in 3+1 dimensions and construct examples of stationary, solitonic-like objects in (3+1)-dimensional flat space-time that consist of two interacting global scalar fields. We concentrate on configurations composed of one spinning and one non-spinning Q-ball and study the parameter-dependence of the energy and charges of the configuration. In addition, we present numerical evidence that for fixed values of the coupling constants two different types of 2-Q-ball solutions exist: solutions with defined parity, but also solutions which are asymmetric with respect to reflexion through the x-y-axis.

  20. Measurements of the Q

    Energy Technology Data Exchange (ETDEWEB)

    P.L. Anthony; R.Greg Arnold; Todd Averett; H.R. Band; M.C. Berisso; H. Borel; Peter Bosted; S.L. Bultmann; M. Buenerd; T. Chupp; Steve Churchwell; G.R. Court; Donald Crabb; Donal Day; P. Decowski; P. DePietro; R. Erbacher; R. Erickson; A. Feltham; Helene Fonvieille; Emil Frlez; R. Gearhart; V. Ghazikhanian; Javier Gomez; Keith Griffioen; Chris Harris; M.A. Houlden; E.W. Hughes; Charles Hyde-Wright; G. Igo; Sebastian Incerti; John Jensen; J.R. Johnson; P.M. King; Yu.G. Kolomensky; Sebastian E. Kuhn; Richard Lindgren; R.M. Lombard-Nelsen; Jacques Marroncle; James McCarthy; Paul McKee; W. Meyer; G.S. Mitchell; Joseph Mitchell; M. Olson; S. Penttila; Gerald Peterson; Gerassimos G. Petratos; R. Pitthan; Dinko Pocanic; R. Prepost; Charles Y. Prescott; Liming Qin; Brian Raue; D. Reyna; L.S. Rochester; Stephen Rock; Oscar Rondon-Aramayo; Franck Sabatie; Ingo Sick; Timothy Smith; Lee Sorrell; F. Staley; S. St. Lorant; L.M. Stuart; Z. Szalata; Y. Terrien; Al Tobias; Luminita Todor; T. Toole; S. Trentalange; D. Walz; Robert Welsh; Frank Wesselmann; T.R. Wright; C.C. Young; Marko Zeier; Hongguo Zhu; Beni Zihlmann

    1999-11-01

    The structure functions g1p and g1n have been measured over the range 0.014 < x < 0.9 and 1 < Q2 < 40 GeV2 using deep-inelastic scattering of 48 GeV longitudinally polarized electrons from polarized protons and deuterons. We find that the Q2 dependence of g1p (g1n) at fixed x is very similar to that of the spin-averaged structure function F1p (F1n). From a NLO QCD fit to all available data we find Gamma{sub 1}{sup p} Gamma{sub 1}{sup n}=0.176 {+-} 0.003 {+-} 0.007$ at Q2=5 GeV2, in agreement with the Bjorken sum rule prediction of 0.182 {+-} 0.005.

  1. Coenzyme Q and Mitochondrial Disease

    Science.gov (United States)

    Quinzii, Catarina M.; Hirano, Michio

    2010-01-01

    Coenzyme Q[subscript 10] (CoQ[subscript 10]) is an essential electron carrier in the mitochondrial respiratory chain and an important antioxidant. Deficiency of CoQ[subscript 10] is a clinically and molecularly heterogeneous syndrome, which, to date, has been found to be autosomal recessive in inheritance and generally responsive to CoQ[subscript…

  2. 1Q84

    Institute of Scientific and Technical Information of China (English)

    谈墨者

    2011-01-01

    1Q84年——我就这么来称呼这个新世界吧。不管喜欢还是不喜欢,目前我已经置身于这"1Q84年"。我必须尽快适应这个带着问号的世界,像被放进陌生森林中的动物一样,为了生存下去,得尽快了解并顺应这里的规则。

  3. RecQ Helicases

    DEFF Research Database (Denmark)

    Larsen, Nicolai Balle; Hickson, Ian D

    2013-01-01

    The RecQ family of DNA helicases is highly conserved throughout -evolution, and is important for the maintenance of genome stability. In humans, five RecQ family members have been identified: BLM, WRN, RECQ4, RECQ1 and RECQ5. Defects in three of these give rise to Bloom's syndrome (BLM), Werner's...... a perturbed S-phase. Finally BLM also plays a role in the suppression and/or resolution of ultra-fine anaphase DNA bridges that form between sister-chromatids during mitosis....

  4. Split Q-balls

    Science.gov (United States)

    Bazeia, D.; Losano, L.; Marques, M. A.; Menezes, R.

    2017-02-01

    We investigate the presence of non-topological solutions of the Q-ball type in (1 , 1) spacetime dimensions. The model engenders the global U (1) symmetry and is of the k-field type, since it contains a new term, of the fourth-order power in the derivative of the complex scalar field. It supports analytical solution of the Q-ball type which is stable quantum mechanically. The new solution engenders an interesting behavior, with the charge and energy densities unveiling a splitting profile.

  5. De novo dup(7)(q21q22.2) and cytogenetics of 7q21q34 duplications.

    Science.gov (United States)

    Rivera, H

    2013-01-01

    We report on a constitutional dup(7)(q21q22.2) and compile 25 similar mid-7q imbalances in order to sort out relevant cytogenetic aspects. The propositus was first karyotyped elsewhere at 2 years of age and found to have a de novo 7q+ chromosome. When reassessed at 22 years of age, he exhibited overt mental disability, marked speech delay, mild short stature, frontal bossing, and mild dysmorphisms. The patient's chromosomes were analyzed in metaphases from a lymphocyte culture by means of G-banding and FISH assays with a wcp 7 and two dual probes, namely ELN (7q11)/D7S2686 (7q22) and ELN (7q11)/D7S486, D7S522 (q31). G-bands revealed a 7q21q22.2 direct duplication that was confirmed by FISH: the 7q+ was entirely painted with the wcp and had two 7q22 signals but a single 7q31 signal. Thus, the patient's karyotype was 46,XY, dup(7)(q21q22.2).ish dup(7)(q21 q22.2)(wcp7+, ELN+, D7S2686++, D7S486+)dn. Among 26 interstitial duplications confined to the segment 7q21q34, 13 were contiguous de novo duplications, one was due to a de novo ins (19;7), and 12 were inherited from carriers of inter-/intrachromosomal insertions or complex rearrangements. Mean paternal and maternal ages in de novo contiguous duplications of paternal/unknown (n = 9) or maternal/unknown (n = 10) descent were 33.44 and 30.9 yr whereas median ages were 29 and 30, respectively. The patient's clinical picture confirms the mild or moderate phenotypical repercussion of mid-7q duplications; among 25 patients born alive, 24 (including six teenagers or older) were still alive when reported on.

  6. Duplication 9q34 syndrome.

    OpenAIRE

    Allderdice, P. W.; Eales, B; Onyett, H; Sprague, W; Henderson, K; Lefeuvre, P A; PAL G

    1983-01-01

    Phenotypic, karyotypic, and developmental homology between affected children of carriers of an inverted insertion (9) (q22.1q34.3q34.1) led to recognition of a new chromosome syndrome: dup 9q34. Individuals with dup 9q34 have slight psychomotor retardation, understand simple directions, and acquire a limited vocabulary. In childhood, many are hyperactive. Clinical features include low birth weight, normal birth length, and initial poor feeding and thriving. Musculo-skeletal systems are affect...

  7. Tetrahedron Equation and Quantum $R$ Matrices for modular double of $U_q(D^{(2)}_{n+1}), U_q(A^{(2)}_{2n})$ and $U_q(C^{(1)}_{n})$

    CERN Document Server

    Kuniba, Atsuo; Sergeev, Sergey

    2014-01-01

    We introduce a homomorphism from the quantum affine algebras $U_q(D^{(2)}_{n+1}), U_q(A^{(2)}_{2n}), U_q(C^{(1)}_{n})$ to the $n$-fold tensor product of the $q$-oscillator algebra ${\\mathcal A}_q$. Their action commute with the solutions of the Yang-Baxter equation obtained by reducing the solutions of the tetrahedron equation associated with the modular and the Fock representations of ${\\mathcal A}_q$. In the former case, the commutativity is enhanced to the modular double of these quantum affine algebras.

  8. Chiral symmetry breaking, duality in the $\\overline{Q}q$ channel and $b \\to \\overline{c}cs$ decays

    CERN Document Server

    Blok, B Yu; Uraltsev, N

    1997-01-01

    We address the issue of the quark-hadron duality in the spectral densities induced by the heavy-light quark currents anti-Q q. In the limit m_Q ->oo, m_q ->0 we observe an enhancement of the physical spectral density compared to the quark one in the scalar and axial channels, due to the Goldstone meson contributions. This may imply that the scale where duality sets in in these channels is higher than in the vector (pseudoscalar) case. Implications for the nonleptonic decays of B mesons (the b -> anti-c cs transition) are considered.

  9. Q Fever Update, Maritime Canada

    Science.gov (United States)

    Marrie, Thomas J.; Campbell, Nancy; McNeil, Shelly A.; Webster, Duncan

    2008-01-01

    Since the 1990s, reports of Q fever in Nova Scotia, Canada, have declined. Passive surveillance for Q fever in Nova Scotia and its neighboring provinces in eastern Canada indicates that the clinical manifestation of Q fever in the Maritime provinces is pneumonia and that incidence of the disease may fluctuate. PMID:18258080

  10. Speeding up Q (λ)- learning

    NARCIS (Netherlands)

    Wiering, M.A.; Schmidhuber, J.

    1998-01-01

    Q(λ)learning uses TD(λ)methods to accelerate Q-learning. The worst case complexity for a single update step of previous online Q(λ) implementations based on lookup tables is bounded by the size of the state action space.Our faster algorithm's worst case complexity is bounded by the number of

  11. Fast Online Q(lambda)

    NARCIS (Netherlands)

    Wiering, M.A.; Schmidhuber, J.

    1998-01-01

    Q(lambda)-learning uses TD(lambda)-methods to accelerate Q-learning. The update complexity of previous online Q(lambda)implementations based on lookup-tables is bounded by the size of the state-action space. Our faster algorithm's update complexity is bounded by the number of actions. The method is

  12. Treatment of melasma with mixed parameters of 1,064-nm Q-switched Nd:YAG laser toning and an enhanced effect of ultrasonic application of vitamin C: a split-face study.

    Science.gov (United States)

    Lee, Mei-Ching; Chang, Chun-Shin; Huang, Yau-Li; Chang, Shyue-Luen; Chang, Chih-Hsiang; Lin, Ying-Fang; Hu, Sindy

    2015-01-01

    Melasma is an acquired pigment disorder showing symmetrical hyperpigmentation of the face characterized by light to dark brown patches with indistinct borders on both cheeks. Melasma is prevalent in middle-aged women with harmless hormone imbalances. It is also known as the mask of pregnancy and is prevalent in most child-bearing women. It fluctuates month by month, and yet, there is no promising treatment. The Q-switched neodymium-doped yttrium aluminum garnet (QS-Nd:YAG) laser (1,064-nm wavelength) was introduced in Asia years ago for both skin toning and treatment of facial pigment. This low-fluence, 1,064-nm QS-Nd: YAG laser also reportedly improved melasma. Adjunctive treatments such as vitamin C iontophoresis or chemical peels were recommended in other reports. The technique using the 1,064-nm QS-Nd:YAG laser for toning and the enhancement of adjunctive treatments need further investigation and long-term follow-up before recommendations for the ideal protocol for melasma treatment can be made. The aim of this study is to evaluate the improvement of melasma using different parameters with the 1,064-nm QS-Nd:YAG laser with ultrasonic application of topical vitamin C. Eight patients, ranging in age from 32 to 45 years (mean 37 years), with long-term melasma were studied. Most of the melasma cases were dermal or mixed-type melasma. The patients had no cosmetic treatment (laser, intense pulsed light, or chemical peel) 1 year prior to the study. The entire face of each patient was treated with the 1,064-nm QS-Nd:YAG laser for four sessions at 1-month intervals. The laser treatment was divided into three parts with different parameters. First, each patient underwent whole face exposure for one pass with an 8-mm spot size at a power of 2.0 J/cm(2). Next, the spot size was shifted to 6 mm at a power of 3.5 J/cm(2) for one full-face pass, and then ended with a 4-mm spot size at 3.2 J/cm(2) for one full-face pass, with multiple passes for the main lesions. The end point

  13. A q-rious positivity

    CERN Document Server

    Warnaar, S Ole

    2010-01-01

    The $q$-binomial coefficients $\\qbinom{n}{m}=\\prod_{i=1}^m(1-q^{n-m+i})/(1-q^i)$, for integers $0\\le m\\le n$, are known to be polynomials with non-negative integer coefficients. This readily follows from the $q$-binomial theorem, or the many combinatorial interpretations of $\\qbinom{n}{m}$. In this note we conjecture an arithmetically motivated generalisation of the non-negativity property for products of ratios of $q$-factorials that happen to be polynomials.

  14. The Spirituality of Q

    Directory of Open Access Journals (Sweden)

    Paul Foster

    2015-03-01

    Full Text Available The term spirituality is notoriously difficult to define, as is evidenced by the discussions between contemporary sociologists of religion. If there are any central elements to such a definition, they revolve around the search for the sacred, and the view that certain practices or beliefs lead to humans being placed in a position of privileged access to the transcendent dimension. Often such spiritual experiences and insights are the result of practices that seek deeper communication with the divine, or stem from contemplative reflection upon one’s purpose in a broader context of universal ontology. This discussion seeks to probe Q for its understanding of spirituality, both in terms of the way the text promotes communication with the divine, as well as offering heightened spiritual experience for adherents to its teaching. In essence, this is an exploration of the way the new religious movement reflected in Q offered its followers contact with the transcendent within the context of everyday human life.

  15. Q-factors of CVD monolayer graphene and graphite inductors

    Science.gov (United States)

    Wang, Zidong; Zhang, Qingping; Peng, Pei; Tian, Zhongzheng; Ren, Liming; Zhang, Xing; Huang, Ru; Wen, Jincai; Fu, Yunyi

    2017-08-01

    A carbon-based inductor may serve as an important passive component in a carbon-based radio-frequency (RF) integrated circuit (IC). In this work, chemical vapor deposition (CVD) synthesized monolayer graphene and graphite inductors are fabricated and their Q-factors are investigated. We find that the large series resistance of signal path (including coil resistance and contact resistance) in monolayer graphene inductors causes negative Q-factors at the whole frequency range in measurement. Comparatively, some of the graphite inductors have all of their Q-factors above zero, due to their small signal path resistance. We also note that some other graphite inductors have negative Q-factor values at low frequency regions, but positive Q-factor values at high frequency regions. With an equivalent circuit model, we confirm that the negative Q-factors of some graphite inductors at low frequency regions are related to their relatively large contact resistances, and we are able to eliminate these negative Q-factors by improving the graphite-metal contact. Furthermore, the peak Q-factor (Q p) can be enhanced by lowering down the resistance of graphite coil. For an optimized 3/4-turn graphite inductor, the measured maximum Q-factor (Q m) can reach 2.36 and the peak Q-factor is theoretically predicted by the equivalent circuit to be as high as 6.46 at a high resonant frequency, which is beyond the testing frequency range. This research indicates that CVD synthesized graphite thin film is more suitable than graphene for fabricating inductors in carbon-based RF IC in the future.

  16. Production and Decay of (Q Q Qbar Qbar) States

    CERN Document Server

    Karliner, Marek; Nussinov, Shmuel

    2016-01-01

    The question of whether there exist bound states of two heavy quarks $Q=(c,b)$ and antiquarks $\\bar Q = (\\bar c, \\bar b)$, distinct from a pair of quark-antiquark mesons, has been debated for more than forty years. We suggest some means of producing and observing $Q_1 Q_2 \\bar Q_3 \\bar Q_4$ resonant states, concentrating on the $c c \\bar c \\bar c$ channel which is most easily produced and the $b b \\bar b \\bar b$ channel which has a better chance of being relatively narrow. We obtain $M_{(cc)(\\bar c \\bar c)} = 6,192 \\pm 25$ MeV and $M_{(bb)(\\bar b \\bar b)} = 18,826 \\pm 25$ MeV, for the charmed and bottom tetraquarks, respectively. Experimental search for these states in the relevant mass region is highly desirable.

  17. Effective Q-Q Interactions in Constituent Quark Models

    CERN Document Server

    Glozman, L Ya; Plessas, W; Varga, K; Wagenbrun, R F

    1998-01-01

    We study the performance of some recent potential models suggested as effective interactions between constituent quarks. In particular, we address constituent quark models for baryons with hybrid Q-Q interactions stemming from one-gluon plus meson exchanges. Upon recalculating two of such models we find them to fail in describing the N and \\Delta spectra. Our calculations are based on accurate solutions of the three-quark systems in both a variational Schrödinger and a rigorous Faddeev approach. It is argued that hybrid {Q-Q} interactions encounter difficulties in describing baryon spectra due to the specific contributions from one-gluon and pion exchanges together. In contrast, a chiral constituent quark model with a Q-Q interaction solely derived from Goldstone-boson exchange is capable of providing a unified description of both the N and \\Delta spectra in good agreement with phenomenology.

  18. q-Bernoulli numbers and q-Bernoulli polynomials revisited

    Directory of Open Access Journals (Sweden)

    Kim Taekyun

    2011-01-01

    Full Text Available Abstract This paper performs a further investigation on the q-Bernoulli numbers and q-Bernoulli polynomials given by Acikgöz et al. (Adv Differ Equ, Article ID 951764, 9, 2010, some incorrect properties are revised. It is point out that the generating function for the q-Bernoulli numbers and polynomials is unreasonable. By using the theorem of Kim (Kyushu J Math 48, 73-86, 1994 (see Equation 9, some new generating functions for the q-Bernoulli numbers and polynomials are shown. Mathematics Subject Classification (2000 11B68, 11S40, 11S80

  19. Gauged Q balls

    Energy Technology Data Exchange (ETDEWEB)

    Lee, K.; Stein-Schabes, J.A.; Watkins, R.; Widrow, L.M.

    1989-03-15

    Classical nontopological soliton configurations are considered within the theory of a complex scalar field with a gauged U(1) symmetry. Their existence and stability against dispersion are demonstrated and some of their properties are investigated analytically and numerically. The soliton configuration is such that inside the soliton the local U(1) symmetry is broken, the gauge field becomes massive, and for a range of values of the coupling constants the soliton becomes a superconductor pushing the charge to the surface. Furthermore, because of the repulsive Coulomb force, there is a maximum size for these objects, making impossible the existence of Q matter in bulk form. We also briefly discuss solitons with fermions in a U(1) gauge theory.

  20. Gauged Q-balls

    Science.gov (United States)

    Lee, Kimyeong; Stein-Schabes, Jaime A.; Watkins, Richard; Widrow, Lawrence M.

    1988-01-01

    Classical non-topological soliton configurations are considered within the theory of a complex scalar field with a gauged U symmetry. Their existence and stability against dispersion are demonstrated and some of their properties are investigated analytically and numerically. The soliton configuration is such that inside the soliton the local U symmetry is broken, the gauge field becomes massive and for a range of values of the coupling constants the soliton becomes a superconductor pushing the charge to the surface. Furthermore, because of the repulsive Coulomb force, there is a maximum size for these objects, making impossible the existence of Q-matter in bulk form. Also briefly discussed are solitons with fermions in a U gauge theory.

  1. Gauged Q-balls

    Energy Technology Data Exchange (ETDEWEB)

    Lee, K.; Stein-Schabes, J.A.; Watkins, R.; Widrow, L.M.

    1988-09-01

    Classical non-topological soliton configurations are considered within the theory of a complex scalar field with a gauged U symmetry. Their existence and stability against dispersion are demonstrated and some of their properties are investigated analytically and numerically. The soliton configuration is such that inside the soliton the local U symmetry is broken, the gauge field becomes massive and for a range of values of the coupling constants the soliton becomes a superconductor pushing the charge to the surface. Furthermore, because of the repulsive Coulomb force, there is a maximum size for these objects, making impossible the existence of Q-matter in bulk form. Also briefly discussed are solitons with fermions in a U gauge theory.

  2. Atmospheric Corrosion of Q235 Carbon Steel and Q450 Weathering Steel in Turpan,China

    Institute of Scientific and Technical Information of China (English)

    Qiang YU; Chao-fang DONG; Yue-hua FANG; Kui XIAO; Chun-yun GUO; Gang HE; Xiao-gang LI

    2016-01-01

    Q235 carbon steel and Q450 weathering steel were exposed to the hot and dry environment of Turpan, China for three years.The corrosion rates of both steels were calculated and compared.The morphologies of the rust layer products were observed by optical microscopy and scanning electron microscopy.Analyses of the rust layers were performed by X-ray photoelectron spectroscopy,X-ray powder diffraction,and Raman spectroscopy,and anal-ysis results indicate that the compositions of rust are main iron rich oxide such as FeOOH,Fe3 O4 ,and Fe2 O3 .The iron oxide layer content proportion was calculated through a semi-quantitative algorithm.The resistance elements (Cr,Ni,and Cu)enhanced the resistance properties of the Q450 weathering steel matrix.Moreover,the resistance elements increased the proportion of goethite crystals in the corroded rust layer.

  3. Roles of two-component system AfsQ1/Q2 in regulating biosynthesis of the yellow-pigmented coelimycin P2 in Streptomyces coelicolor.

    Science.gov (United States)

    Chen, Shuangshuang; Zheng, Guosong; Zhu, Hong; He, Huiqi; Chen, Lei; Zhang, Weiwen; Jiang, Weihong; Lu, Yinhua

    2016-08-01

    We previously demonstrated that in Streptomyces coelicolor two-component system AfsQ1/Q2 activates the production of the yellow-colored coelimycin P2 (also named as yCPK) on glutamate-supplemented minimal medium, and the response regulator AfsQ1 could specifically bind to the intergenic region between two structural genes, cpkA and cpkD Here, a more in-depth investigation was performed to elucidate the mechanism underlying the role of AfsQ1/Q2 in regulating coelimycin P2 biosynthesis. Deletion of afsQ1/Q2 resulted in markedly decreased expression of the whole coelimycin P2 biosynthetic gene cluster. Electrophoretic mobility shift assays revealed that AfsQ1 bound only to the target site identified previously, but not to any other promoters in the gene cluster. Mutations of AfsQ1-binding motif only resulted in drastically reduced transcription of the cpkA/B/C operon (encoding three type I polyketide synthases) and intriguingly, led to enhanced expression of some coelimcyin P2 genes, particularly accA1 and scF These results suggested the direct role of AfsQ1/Q2 in regulating coelimycin production, which is directly mediated by the structural genes, but not the cluster-situated regulatory genes, and also implied that other unknown mechanisms may be involved in AfsQ1/Q2-mediated regulation of coelimycin P2 biosynthesis.

  4. Duplication 9q34 syndrome.

    Science.gov (United States)

    Allderdice, P W; Eales, B; Onyett, H; Sprague, W; Henderson, K; Lefeuvre, P A; Pal, G

    1983-09-01

    Phenotypic, karyotypic, and developmental homology between affected children of carriers of an inverted insertion (9) (q22.1q34.3q34.1) led to recognition of a new chromosome syndrome: dup 9q34. Individuals with dup 9q34 have slight psychomotor retardation, understand simple directions, and acquire a limited vocabulary. In childhood, many are hyperactive. Clinical features include low birth weight, normal birth length, and initial poor feeding and thriving. Musculo-skeletal systems are affected: there are joint contractures, long thin limbs, and striking arachnodactyly. There is abnormal implantation of the thumb, increased space between the first and second fingers, and excess digital creases. Marfan syndrome was a provisional diagnosis for several cases prior to cytogenetic analysis. Cardiovascular and ocular systems are minimally affected, erythema and heart murmurs occur, and ptosis and strabismus are frequent, but lens dislocation is not observed. Features at birth include: dolichocephaly, facial asymmetry, narrow horizontal palpebral fissures, microphthalmia, prominent nasal bridge, small mouth, thin upper lip with down-turned corners, and slight retrognathia. In older children, retrognathia is diminished and the nose becomes long and narrow. The new culture and chromosome banding techniques enable sorting of cases with the distal dup 9q phenotype into two groups. The cases with a longer dup 9q are more likely to develop with life-threatening congenital anomalies. The cases with the shorter dup 9q34 have a less severe long-term prognosis and will benefit, together with their parents, from special education. Female carriers of the inv ins(9) (q22.1q34.3q34.1) have about a 31% risk in each pregnancy to conceive a fetus affected by the dup 9q34 syndrome. A comparable figure is not yet available for male carriers.

  5. Q-bank phytoplasma database

    DEFF Research Database (Denmark)

    Contaldo, Nicoletta; Bertaccini, Assunta; Nicolaisen, Mogens

    2014-01-01

    The setting of the Q-Bank database free available on line for quarantine phytoplasma and also for general phytoplasma identification is described. The tool was developed in the frame of the EU-FP7 project Qbol and is linked with a new project Q-collect in order to made widely available the identi......The setting of the Q-Bank database free available on line for quarantine phytoplasma and also for general phytoplasma identification is described. The tool was developed in the frame of the EU-FP7 project Qbol and is linked with a new project Q-collect in order to made widely available...

  6. Q3/Q4 2016 Solar Industry Update

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, David; Boff, Daniel; Margolis, Robert

    2016-12-21

    This technical presentation provides an update on the major trends that occurred in the solar industry in the Q3 and Q4 of 2016. Major topics of focus include global and U.S. supply and demand, module and system price, investment trends and business models, and updates on U.S. government programs supporting the solar industry.

  7. Q2/Q3 2016 Solar Industry Update

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, David; Boff, Daniel; Margolis, Robert

    2016-10-11

    This technical presentation provides an update on the major trends that occurred in the solar industry in the Q2 and Q3 of 2016. Major topics of focus include global and U.S. supply and demand, module and system price, investment trends and business models, and updates on U.S. government programs supporting the solar industry.

  8. Relative bioavailability and antioxidant potential of two coenzyme q10 preparations.

    Science.gov (United States)

    Kurowska, Elzbieta M; Dresser, George; Deutsch, Luisa; Bassoo, Errol; Freeman, David J

    2003-01-01

    Coenzyme Q10 (CoQ10) is synthesized by the human body and found in certain foods. Daily supplementation of CoQ10 could protect against heart disease but the bioavailability of CoQ10 supplements depends on the formulation taken. We compared the bioavailability and antioxidant properties of two commercial CoQ10 formulations, a commercial grade CoQ10 powder (commercial grade CoQ) and a new BT-CoQ10 BIO-TRANSFORMED (BT-CoQ10) obtained by fermentation of a soy-based, CoQ10-rich media with baker's yeast. Eleven healthy individuals participated in a randomized two-way crossover trial, with a 3-week washout period. Capsules containing 300 mg of either BT-CoQ10 or commercial grade CoQ10 were given daily for 1 week and multiple blood samples were taken for CoQ10, glutathione and glutathione peroxidase (GPx) determination. In 3 subjects, baseline plasma CoQ10 levels were lower prior to BT than prior to commercial grade CoQ treatment. In the remaining participants, ingestion of BT vs. commercial grade CoQ significantly increased maximum plasma CoQ10 concentration (+126%, p = 0.04) and tended to increase CoQ10 area under the curve from 0 to 24 h (+160%, p = 0.07). One week of treatment with each formulation increased plasma CoQ10 but did not alter plasma glutathione or GPx activity. The enhanced bioavailability of the BT product might be due to its predominantly reduced, hydrophilic membrane-complex form. Copyright 2003 S. Karger AG, Basel

  9. Q-bank phytoplasma database

    DEFF Research Database (Denmark)

    Contaldo, Nicoletta; Bertaccini, Assunta; Nicolaisen, Mogens

    2014-01-01

    The setting of the Q-Bank database free available on line for quarantine phytoplasma and also for general phytoplasma identification is described. The tool was developed in the frame of the EU-FP7 project Qbol and is linked with a new project Q-collect in order to made widely available...

  10. On Q-derived polynomials

    NARCIS (Netherlands)

    R.J. Stroeker (Roel)

    2002-01-01

    textabstractA Q-derived polynomial is a univariate polynomial, defined over the rationals, with the property that its zeros, and those of all its derivatives are rational numbers. There is a conjecture that says that Q-derived polynomials of degree 4 with distinct roots for themselves and all their

  11. On Q-derived polynomials

    NARCIS (Netherlands)

    R.J. Stroeker (Roel)

    2006-01-01

    textabstractA Q-derived polynomial is a univariate polynomial, defined over the rationals, with the property that its zeros, and those of all its derivatives are rational numbers. There is a conjecture that says that Q-derived polynomials of degree 4 with distinct roots for themselves and all their

  12. Q fever: The Dutch Policy

    NARCIS (Netherlands)

    Bruschke, C.J.M.; Roest, H.I.J.; Coutinho, R.A.

    2016-01-01

    Between 2007 and 2010, the Netherlands experienced an unprecedented outbreak of Q fever of more than 4000 human cases. Q fever infections of dairy goats, leading to abortion waves, were considered to be the cause of this outbreak. Measures to combat the outbreak had to be taken based on limited scie

  13. [Production of coenzyme Q10 by metabolically engineered Escherichia coli].

    Science.gov (United States)

    Dai, Guanping; Miao, Liangtian; Sun, Tao; Li, Qingyan; Xiao, Dongguang; Zhang, Xueli

    2015-02-01

    Coenzyme Q10 (CoQ10) is a lipophilic antioxidant that improves human immunity, delays senility and enhances the vitality of the human body and has wide applications in pharmaceutical and cosmetic industries. Microbial fermentation is a sustainable way to produce CoQ10, and attracts increased interest. In this work, the native CoQ8 synthetic pathway of Escherichia coli was replaced by the CoQ10 synthetic pathway through integrating decaprenyl diphosphate synthase gene (dps) from Rhodobacter sphaeroides into chromosome of E. coli ATCC 8739, followed by deletion of the native octaprenyl diphosphate synthase gene (ispB). The resulting strain GD-14 produced 0.68 mg/L CoQ10 with a yield of 0.54 mg/g DCW. Modulation of dxs and idi genes of the MEP pathway and ubiCA genes in combination led to 2.46-fold increase of CoQ10 production (from 0.54 to 1.87 mg/g DCW). Recruiting glucose facilitator protein of Zymomonas mobilis to replace the native phosphoenolpyruvate: carbohydrate phosphotransferase systems (PTS) further led to a 16% increase of CoQ10 yield. Finally, fed-batch fermentation of the best strain GD-51 was performed, which produced 433 mg/L CoQ10 with a yield of 11.7 mg/g DCW. To the best of our knowledge, this was the highest CoQ10 titer and yield obtained for engineered E. coli.

  14. Fragility in the 14q21q translocation region

    Directory of Open Access Journals (Sweden)

    Stacy R. Denison

    2002-01-01

    Full Text Available Aphidicolin (APC-induced chromosomal breakage was analyzed for women representing three generations of a single family and carrying a Robertsonian translocation rob(14q21q. Fluorescence in situ hybridization (FISH analysis confirmed the dicentric constitution of the derived chromosome and indicated the absence of beta-satellite signal at the translocation region. Per-individual analysis of metaphases from APC-treated peripheral blood lymphocyte cultures identified significantly nonrandom chromosomal breakage at the translocation region in all three individuals examined. The APC-inducible fragility at the 14q21q translocation region suggests that this rearrangement was the result of chromosomal mutation at fragile site(s in the progenitor chromosomes, or that this fragility was the result of the fusion of nonfragile progenitor chromosomes.

  15. Enhancement of shortening velocity, power, and acto-myosin crossbridge (CB) kinetics following long-term treatment with propionyl-L-carnitine, coenzyme Q10, and omega-3 fatty acids in BIO TO-2 cardiomyopathic Syrian hamsters papillary muscle.

    Science.gov (United States)

    Vargiu, Romina; Littarru, Gian Paolo; Fraschini, Matteo; Perinu, Anna; Tiano, Luca; Capra, Alessandro; Mancinelli, Rino

    2010-01-01

    Impaired functions of myocardial muscle cells in human and animals, is a primary defect associated with idiopathic dilated cardiomyopathy (DCM). The pathophysiological mechanisms implicated in the DCM are yet to be clarified and an effective therapy is still not available. The BIO TO-2 cardiomyopathic Syrian Hamsters (CMSHs) represent an animal model of idiopathic DCM. The aim of this study was to investigate the effect of long-term treatment (2 months) with propionyl-L-carnitine (PLC), coenzyme Q(10), omega-3 fatty acids and a combination of these three agents (formulation HS12607) on mechanical properties and acto-myosin crossbridges (CBs) kinetics of left ventricular (LV) papillary muscle from control and treated 10 month old BIO TO-2 CMSHs. Isometric and isotonic contractile properties of isolated papillary muscle from control and treated CMSHs were investigated, and acto-myosin CB number, force and kinetics were calculated using Huxley's equations. Mechanical parameter values were higher in treated than in control hamsters, particularly when substances were administered together in a coformulation (HS12607). Compared to control, HS12607-treated papillary muscles showed a significant increase of maximum peak isometric tension (P(o)) (30.06 +/- 4.91 vs. 19.74 +/- 5.00 mN/mm(2)), maximum extent of muscle shortening (0.13 +/- 0.03 vs. 0.07 +/- 0.02 L/L(max)), maximum unloaded shortening velocity (1.18 +/- 0.24 vs. 0.53 +/- 0.13 L/L(max) s(-1)) and maximum peak of power output (5.52 +/- 1.61 vs. 1.58 +/- 0.83). The curvature of the hyperbolic force-velocity relationships did not differ between control and treated hamsters. When compared to controls, acto-myosin CB number increased in treated hamsters [(6.67 +/- 1.91) 10(10)/mm(2) vs. (3.55 +/- 2.08) 10(10)/mm(2)], whereas the unitary force of single CB was similar in control and treated animals. The peak value of the rate constant for CB attachment (f(1)) and detachment (g(2)) was higher in treated animals when

  16. The Physical Squeezed Limit: Consistency Relations at Order q^2

    CERN Document Server

    Creminelli, Paolo; Senatore, Leonardo; Simonović, Marko; Trevisan, Gabriele

    2013-01-01

    In single-field models of inflation the effect of a long mode with momentum q reduces to a diffeomorphism at zeroth and first order in q. This gives the well-known consistency relations for the n-point functions. At order q^2 the long mode has a physical effect on the short ones, since it induces curvature, and we expect that this effect is the same as being in a curved FRW universe. In this paper we verify this intuition in various examples of the three-point function, whose behaviour at order q^2 can be written in terms of the power spectrum in a curved universe. This gives a simple alternative understanding of the level of non-Gaussianity in single-field models. Non-Gaussianity is always parametrically enhanced when modes freeze at a physical scale k_{ph, f} shorter than H: f_{NL} \\sim (k_{ph, f}/H)^2.

  17. The physical squeezed limit: consistency relations at order q2

    Science.gov (United States)

    Creminelli, Paolo; Perko, Ashley; Senatore, Leonardo; Simonović, Marko; Trevisan, Gabriele

    2013-11-01

    In single-field models of inflation the effect of a long mode with momentum q reduces to a diffeomorphism at zeroth and first order in q. This gives the well-known consistency relations for the n-point functions. At order q2 the long mode has a physical effect on the short ones, since it induces curvature, and we expect that this effect is the same as being in a curved FRW universe. In this paper we verify this intuition in various examples of the three-point function, whose behaviour at order q2 can be written in terms of the power spectrum in a curved universe. This gives a simple alternative understanding of the level of non-Gaussianity in single-field models. Non-Gaussianity is always parametrically enhanced when modes freeze at a physical scale kph, f shorter than H: fNL ~ (kph, f/H)2.

  18. Q fever in French Guiana.

    Science.gov (United States)

    Eldin, Carole; Mahamat, Aba; Demar, Magalie; Abboud, Philippe; Djossou, Félix; Raoult, Didier

    2014-10-01

    Coxiella burnetii, the causative agent of Q fever, is present worldwide. Recent studies have shown that this bacterium is an emerging pathogen in French Guiana and has a high prevalence (24% of community-acquired pneumonia). In this review, we focus on the peculiar epidemiology of Q fever in French Guiana. We place it in the context of the epidemiology of the disease in the surrounding countries of South America. We also review the clinical features of Q fever in this region, which has severe initial presentation but low mortality rates. These characteristics seem to be linked to a unique genotype (genotype 17). Finally, we discuss the issue of the animal reservoir of C. burnetii in French Guiana, which is still unknown. Further studies are necessary to identify this reservoir. Identification of this reservoir will improve the understanding of the Q fever epidemic in French Guiana and will provide new tools to control this public health problem.

  19. Q Vara ehitab tootmismaad laopargiks

    Index Scriptorium Estoniae

    2007-01-01

    Kinnisvarafirma Q Vara OÜ alustab 2007. a. mais Rae vallas Tallinna ringtee ääres asuva 168000 m2 suuruse tootmismaa ümberehitamist laopargiks. Ettevõtte projektijuhi Jaak Puistma sõnul jagatakse laopark 22 krundiks

  20. Minimum Q Electrically Small Antennas

    DEFF Research Database (Denmark)

    Kim, O. S.

    2012-01-01

    for a multiarm spherical helix antenna confirm the theoretical predictions. For example, a 4-arm spherical helix antenna with a magnetic-coated perfectly electrically conducting core (ka=0.254) exhibits the Q of 0.66 times the Chu lower bound, or 1.25 times the minimum Q.......Theoretically, the minimum radiation quality factor Q of an isolated resonance can be achieved in a spherical electrically small antenna by combining TM1m and TE1m spherical modes, provided that the stored energy in the antenna spherical volume is totally suppressed. Using closed-form expressions...... for the stored energies obtained through the vector spherical wave theory, it is shown that a magnetic-coated metal core reduces the internal stored energy of both TM1m and TE1m modes simultaneously, so that a self-resonant antenna with the Q approaching the fundamental minimum is created. Numerical results...

  1. FEMA Q3 Flood Data

    Data.gov (United States)

    Kansas Data Access and Support Center — The Q3 Flood Data are derived from the Flood Insurance Rate Maps (FIRMS) published by the Federal Emergency Management Agency (FEMA). The file is georeferenced to...

  2. Civilsamfundets ABC: Q for Quango

    DEFF Research Database (Denmark)

    Lund, Anker Brink; Meyer, Gitte

    2016-01-01

    Bogstaveligt talt: Hvad er civilsamfundet? Anker Brink Lund og Gitte Meyer fra CBS Center for Civil Society Studies gennemgår civilsamfundet bogstav for bogstav. Vi er nået til Q for Quango.......Bogstaveligt talt: Hvad er civilsamfundet? Anker Brink Lund og Gitte Meyer fra CBS Center for Civil Society Studies gennemgår civilsamfundet bogstav for bogstav. Vi er nået til Q for Quango....

  3. q-ary compressive sensing

    OpenAIRE

    Mroueh, Youssef; Rosasco, Lorenzo

    2013-01-01

    We introduce q-ary compressive sensing, an extension of 1-bit compressive sensing. We propose a novel sensing mechanism and a corresponding recovery procedure. The recovery properties of the proposed approach are analyzed both theoretically and empirically. Results in 1-bit compressive sensing are recovered as a special case. Our theoretical results suggest a tradeoff between the quantization parameter q, and the number of measurements m in the control of the error of the resulting recovery a...

  4. Some properties of deformed q-numbers

    OpenAIRE

    Lobão, Thierry C. Petit; Cardoso, Pedro G. S.; Pinho, Suani T. R.; Borges, Ernesto P.

    2009-01-01

    p. 402/407 Nonextensive statistical mechanics has been a source of investigation in mathematical structures such as deformed algebraic structures. In this work, we present some consequences of q-operations on the construction of q-numbers for all numerical sets. Based on such a construction, we present a new product that distributes over the q-sum. Finally, we present different patterns of q-Pascal’s triangles, based on q-sum, whose elements are q-numbers.

  5. Some properties of deformed $q$-numbers

    OpenAIRE

    Lobão, Thierry C. Petit; Cardoso, Pedro G. S.; Pinho, Suani T. R.; Borges, Ernesto P.

    2009-01-01

    Nonextensive statistical mechanics has been a source of investigation in mathematical structures such as deformed algebraic structures. In this work, we present some consequences of $q$-operations on the construction of $q$-numbers for all numerical sets. Based on such a construction, we present a new product that distributes over the $q$-sum. Finally, we present different patterns of $q$-Pascal's triangles, based on $q$-sum, whose elements are $q$-numbers.

  6. Enabling ICH Q10 Implementation--Part 1. Striving for Excellence by Embracing ICH Q8 and ICH Q9.

    Science.gov (United States)

    Calnan, Nuala; O'Donnell, Kevin; Greene, Anne

    2013-01-01

    This article is the first in a series of articles that will focus on understanding the implementation essentials necessary to deliver operational excellence through a International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) Q10-based pharmaceutical quality system (PQS). The authors examine why, despite the fact that the ICH Q10 guideline has been with us since 2008, the transformation of the traditional Quality Management Systems QMS in use within the pharmaceutical industry is a work in progress for only a few forward-thinking organisations. Unfortunately, this transformation remains a mere aspiration for the majority of organisations. We explore the apparent lack of progress by the pharmaceutical sector in adopting six sigma and related quality management techniques to ensure the availability of high-quality medicines worldwide. The authors propose that the desired progress can be delivered through two key shifts in our current practices; by embodying the principles of operational excellence in every aspect of our business and by learning how to unlock the scientific and tacit knowledge within our organisations. It has been ten years since The Wall Street Journal revealed the pharmaceutical industry's "little secret" comparing the perceived level of manufacturing expertise in the industry as lagging far behind those of potato-chip and laundry-soap makers. Would you consider the quality and manufacturing strategies in place today in your organisation to be more efficient and scientifically based than those of 2003? If so, what evidence exists for you to draw any conclusion regarding enhanced performance? Do your current practices drive innovation and facilitate continual improvement and if so, how? Ultimately, can you confidently affirm that patient-related risks associated with the product(s) manufactured by your organisation have been reduced due to the quality assurance program now applied

  7. The production and secretion of complement component C1q by human mast cells.

    Science.gov (United States)

    van Schaarenburg, Rosanne A; Suurmond, Jolien; Habets, Kim L L; Brouwer, Mieke C; Wouters, Diana; Kurreeman, Fina A S; Huizinga, Tom W J; Toes, René E M; Trouw, Leendert A

    2016-10-01

    C1q is the initiation molecule of the classical pathway of the complement system and is produced by macrophages and immature dendritic cells. As mast cells share the same myeloid progenitor cells, we have studied whether also mast cells can produce and secrete C1q. Mast cells were generated in vitro from CD34+ progenitor cells from buffy coats or cord blood. Fully differentiated mast cells were shown by both RNA sequencing and qPCR to express C1QA, C1QB and C1QC. C1q produced by mast cells has a similar molecular make-up as serum C1q. Reconstituting C1q depleted serum with mast cell supernatant in haemolytic assays, indicated that C1q secreted by mast cells is functionally active. The level of C1q in supernatants produced under basal conditions was considerably enhanced upon stimulation with LPS, dexamethasone in combination with IFN- γ or via FcεRI triggering. Mast cells in human tissues stained positive for C1q in both healthy and in inflamed tissue. Moreover, mast cells in healthy and diseased skin appear to be the predominant C1q positive cells. Together, our data reveal that mast cells are able to produce and secrete functional active C1q and indicate mast cells as a local source of C1q in human tissue. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  8. Partial monosomy 8q and partial trisomy 9q due to the maternal translocation t(8;9(q24.3;q34.1)

    DEFF Research Database (Denmark)

    Tos, T; Alp, M Y; Eker, H K;

    2014-01-01

    Partial trisomy 9q34-qter and partial monosomy 8q24.3-qter are very rare chromosomal abnormalities. Characteristic features of partial trisomy 9q34-qter are hypotonia, developmental delay, mild intellectual disability, dolichocephaly, distinct facial phenotype, long and thin fingers, and cardiac...... anomalies. Unlike the partial trisomy 9q34-qter, partial monosomy 8q24.3-qter has no distinct phenotype. Here we report a four years old female patient with partial trisomy 9q34-qter and partial monosomy 8q24.3-qter due to the maternal translocation t(8;9)(q24.3;q34. I). She has developmental delay......, brachycephaly, facial dysmorphism, hand and foot anomalies, bilateral hearing loss, cardiac defect and abnormal brain MRI findings. To the best of our knowledge, this is the first report of the combination of partial trisomy 9q and partial monosomy 8q....

  9. Pure partial trisomy 4q syndrome in a child with der(9)ins(9;4)(q34.3;q26q35.2)mat.

    Science.gov (United States)

    Topcu, V; Ilgin-Ruhi, H; Yurur-Kutlay, N; Ekici, C; Vicdan, A; Tukun, F A

    2014-01-01

    Pure partial trisomy 4q syndrome in a child with der(9)ins(9;4)(q34.3;q26q35.2)mat: Partial trisomy 4q is a rare chromosomal abnormality and mostly results from unbalanced inheritance of balanced parental chromosomal translocations. Here, we present a 5-year-old boy with partial trisomy 4q who exhibited distinctive features of 'pure' partial trisomy 4q syndrome including moderate mental and growth retardation, microcephaly, peculiar face appearance, tooth anomaly, cleft palate, language handicap, preaxial polydactyly, and urogenital anomaly. Karyotype analysis of the child revealed der(9)ins(9;4)(q34.3;q26q35.2) inherited from mother carrying ins(9;4)(q34.3;q26q35.2) resulting in trisomy of the 4q26qter segment. Whole chromosome painting, locus specific, and subtelomeric FISH analysis in mother proved that q26qter of the chromosome 4 segment was directly inserted into the telomeric sequence in chromosome 9, and depending on nature of the rearrangement in mother, karyotype of the child was determined to be pure partial 4q trisomy. This is the first report of this kind of rearrangement causing pure partial trisomy 4q with accompanying white matter change demonstrated by MRI and bilateral preaxial polydactyly of both hands.

  10. Wave-equation Q tomography

    KAUST Repository

    Dutta, Gaurav

    2016-10-12

    Strong subsurface attenuation leads to distortion of amplitudes and phases of seismic waves propagating inside the earth. The amplitude and the dispersion losses from attenuation are often compensated for during prestack depth migration. However, most attenuation compensation or Qcompensation migration algorithms require an estimate of the background Q model. We have developed a wave-equation gradient optimization method that inverts for the subsurface Q distribution by minimizing a skeletonized misfit function ∈, where ∈ is the sum of the squared differences between the observed and the predicted peak/centroid-frequency shifts of the early arrivals. The gradient is computed by migrating the observed traces weighted by the frequency shift residuals. The background Q model is perturbed until the predicted and the observed traces have the same peak frequencies or the same centroid frequencies. Numerical tests determined that an improved accuracy of the Q model by wave-equation Q tomography leads to a noticeable improvement in migration image quality. © 2016 Society of Exploration Geophysicists.

  11. Multivariable q-Racah polynomials

    CERN Document Server

    Van Diejen, J F

    1996-01-01

    The Koornwinder-Macdonald multivariable generalization of the Askey-Wilson polynomials is studied for parameters satisfying a truncation condition such that the orthogonality measure becomes discrete with support on a finite grid. For this parameter regime the polynomials may be seen as a multivariable counterpart of the (one-variable) q-Racah polynomials. We present the discrete orthogonality measure, expressions for the normalization constants converting the polynomials into an orthonormal system (in terms of the normalization constant for the unit polynomial), and we discuss the limit q\\rightarrow 1 leading to multivariable Racah type polynomials. Of special interest is the situation that q lies on the unit circle; in that case it is found that there exists a natural parameter domain for which the discrete orthogonality measure (which is complex in general) becomes real-valued and positive. We investigate the properties of a finite-dimensional discrete integral transform for functions over the grid, whose ...

  12. Certain Properties of q-Hypergeometric Functions

    Directory of Open Access Journals (Sweden)

    Uzoamaka A. Ezeafulukwe

    2015-01-01

    Full Text Available The quotients of certain q-hypergeometric functions are presented as g-fractions which converge uniformly in the unit disc. These results lead to the existence of certain q-hypergeometric functions in the class of either q-convex functions, PCq, or q-starlike functions PSq*.

  13. q-exponentials on quantum spaces

    Energy Technology Data Exchange (ETDEWEB)

    Wachter, H. [Ludwig-Maximilians-Universitaet, Sektion Physik, Muenchen (Germany)

    2004-10-01

    We present explicit formulae for q-exponentials on quantum spaces which could be of particular importance in physics, i.e. the q-deformed Minkowski space and the q-deformed Euclidean space with two, three or four dimensions. Furthermore, these formulae can be viewed as 2-, 3- or 4-dimensional analogues of the well-known q-exponential function. (orig.)

  14. Q98 人类学

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Q985 2005062743脑源性神经营养因子及其受体在人卵巢的表达与卵泡发育的关系=Expression of brain-derived neurotrophin factor and its receptor-tyrosine kinase receptor B in human ovary and their significance;Q987 2005062744强直性脊柱炎的新易感基因识别研究=Recognition and study of susceptible gene to ankylosing spondylitis;……

  15. Exploring possibly existing $q q \\bar b \\bar b$ tetraquark states with $q q = ud, ss, cc$

    CERN Document Server

    Peters, Antje; Cichy, Krzysztof; Wagenbach, Björn; Wagner, Marc

    2015-01-01

    We compute potentials of two static antiquarks in the presence of two quarks $qq$ of finite mass using lattice QCD. In a second step we solve the Schr\\"odinger equation, to determine, whether the resulting potentials are sufficiently attractive to host a bound state, which would indicate the existence of a stable $q q \\bar b \\bar b$ tetraquark. We find a bound state for $qq=(ud-du)/\\sqrt{2}$ with corresponding quantum numbers $I(J^ P)=0(1^+)$ and evidence against the existence of bound states with isospin $I=1$ or $qq \\in \\{cc,ss \\}$

  16. Multiple q-Zeta Brackets

    Directory of Open Access Journals (Sweden)

    Wadim Zudilin

    2015-03-01

    Full Text Available The multiple zeta values (MZVs possess a rich algebraic structure of algebraic relations, which is conjecturally determined by two different (shuffle and stuffle products of a certain algebra of noncommutative words. In a recent work, Bachmann constructed a q-analogue of the MZVs—the so-called bi-brackets—for which the two products are dual to each other, in a very natural way. We overview Bachmann’s construction and discuss the radial asymptotics of the bi-brackets, its links to the MZVs, and related linear (independence questions of the q-analogue.

  17. Moments of q-Normal and conditional q-Normal distributions

    OpenAIRE

    2015-01-01

    We calculate moments and moment generating functions of two distributions: the so called $q-$Normal and the so called conditional $q-$Normal distributions. These distributions generalize both Normal ($q=1),$ Wigner ($% q=0,$ $q-$Normal) and Kesten-McKay ($q=0,$ conditional $q-$Normal) distributions. As a by product we get asymptotic properties of some expansions in modified Bessel functions.

  18. On a q-Analogue of the Elzaki Transform Called Mangontarum q-Transform

    Directory of Open Access Journals (Sweden)

    Mahid M. Mangontarum

    2014-01-01

    Full Text Available Two q-analogues of the Elzaki transform, called Mangontarum q-transforms, are introduced in this paper. Properties such as the transforms of q-trigonometric functions, transform of q-derivatives, duality relation, convolution identity, q-derivative of transforms, and transform of the Heaviside function are derived and presented. Moreover, we will consider applications of the Mangontarum q-transform of the first kind to some ordinary q-differential equations with initial values.

  19. Group Delay of High Q Antennas

    DEFF Research Database (Denmark)

    Bahramzy, Pevand; Pedersen, Gert Frølund

    2013-01-01

    become an issue, when working with high Q antennas, because of the steep phase shift over the frequency. In this paper, it is measured how large group delay variations can become, when going from a low Q antenna to a high Q antenna. The group delay of a low Q antenna is shown to be around 1.3 ns, whereas...... a high Q antenna has group delay of around 22 ns. It is due to this huge group delay variation characteristics of high Q antennas, that signal distortion might occur in the radio system with high Q antennas....

  20. Coexistent t(8;21)(q22;q22) Translocation and 5q Deletion in Acute Myeloid Leukemia.

    Science.gov (United States)

    Yamamoto, Katsuya; Yakushijin, Kimikazu; Sanada, Yukinari; Kawamoto, Shinichiro; Matsuoka, Hiroshi; Minami, Hironobu

    2015-01-01

    The t(8;21)(q22;q22) translocation is specifically observed in acute myeloid leukemia (AML) M2 subtype, whereas del(5q) is one of the most common cytogenetic aberrations in myelodysplastic syndromes (MDS). Thus, t(8;21)(q22;q22) and del(5q) appear to be mutually exclusive, and the association between them has not been characterized yet. Here, we report an 81-year-old woman with coexistent t(8;21)(q22;q22) and del(5q) at initial diagnosis. The bone marrow was infiltrated with 18.4% myeloblasts, and showed marked myeloid and erythroid dysplasia. Myeloblasts were positive for CD19 and CD56 as well as CD13, CD33, CD34 and HLA-DR. G-banding and spectral karyotyping showed 46,XX,del(5)(q?),t(8;21)(q22;q22)[18]/46,XX[2]. Both del(5)(q?) and t(8;21)(q22;q22) were present in a single clone. Fluorescence in situ hybridization (FISH) on metaphase spreads detected a RUNX1/RUNX1T1 fusion signal on the der(8)t(8;21)(q22;q22), and confirmed deletion of CSF1R signaling at 5q33-q34 on the del(5)(q?). Furthermore, FISH on interphase nuclei revealed that the RUNX1/RUNX1T1 fusion signal and deletion of CSF1R signaling were found in 66.0% and 58.0% of interphase cells, respectively, suggesting that del(5)(q?) occurred in cells with RUNX1/RUNX1T1. These results indicated a diagnosis of AML with t(8;21)(q22;q22)/RUNX1/RUNX1T1 rather than MDS, even though the percentage of bone marrow myeloblasts was less than 20%. Based on these findings, together with those of other reported cases, del(5q) seems to be an extremely rare but recurrent secondary aberration in AML with t(8;21)(q22;q22).

  1. New multilevel codes over GF(q)

    Science.gov (United States)

    Wu, Jiantian; Costello, Daniel J., Jr.

    1992-01-01

    Set partitioning to multi-dimensional signal spaces over GF(q), particularly GF sup q-1(q) and GF sup q (q), and show how to construct both multi-level block codes and multi-level trellis codes over GF(q). Two classes of multi-level (n, k, d) block codes over GF(q) with block length n, number of information symbols k, and minimum distance d sub min greater than or = d, are presented. These two classes of codes use Reed-Solomon codes as component codes. They can be easily decoded as block length q-1 Reed-Solomon codes or block length q or q + 1 extended Reed-Solomon codes using multi-stage decoding. Many of these codes have larger distances than comparable q-ary block codes, as component codes. Low rate q-ary convolutional codes, work error correcting convolutional codes, and binary-to-q-ary convolutional codes can also be used to construct multi-level trellis codes over GF(q) or binary-to-q-ary trellis codes, some of which have better performance than the above block codes. All of the new codes have simple decoding algorithms based on hard decision multi-stage decoding.

  2. Q methodology in health economics.

    Science.gov (United States)

    Baker, Rachel; Thompson, Carl; Mannion, Russell

    2006-01-01

    The recognition that health economists need to understand the meaning of data if they are to adequately understand research findings which challenge conventional economic theory has led to the growth of qualitative modes of enquiry in health economics. The use of qualitative methods of exploration and description alongside quantitative techniques gives rise to a number of epistemological, ontological and methodological challenges: difficulties in accounting for subjectivity in choices, the need for rigour and transparency in method, and problems of disciplinary acceptability to health economists. Q methodology is introduced as a means of overcoming some of these challenges. We argue that Q offers a means of exploring subjectivity, beliefs and values while retaining the transparency, rigour and mathematical underpinnings of quantitative techniques. The various stages of Q methodological enquiry are outlined alongside potential areas of application in health economics, before discussing the strengths and limitations of the approach. We conclude that Q methodology is a useful addition to economists' methodological armoury and one that merits further consideration and evaluation in the study of health services.

  3. PNIPAM nanoparticles for targeted and enhanced nose-to-brain delivery of curcuminoids: UPLC/ESI-Q-ToF-MS/MS-based pharmacokinetics and pharmacodynamic evaluation in cerebral ischemia model.

    Science.gov (United States)

    Ahmad, Niyaz; Ahmad, Iqbal; Umar, Sadiq; Iqbal, Zeenat; Samim, Mohd; Ahmad, Farhan Jalees

    2016-09-01

    Stroke is a one of the leading causes of disease and deaths worldwide, which causes irreversible deterioration of the central nervous system. Curcuminoids are reported to have a potential role in the amelioration of cerebral ischemia but they exhibit low serum and tissue levels due to low solubility and poor absorption. Curcumin (CUR), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC)-loaded PNIPAM nanoparticles (NPs) were prepared by free radical polymerization and characterized for particles size, entrapment efficiency, zeta potential, in vitro release and ex vivo permeation study. Optimized CUR, DMC and BDMC-loaded NPs had the mean size of 92.46 ± 2.8, 91.23 ± 4.2 and 94.28 ± 1.91 nm; zeta potential of -16.2 ± 1.42, -15.6 ± 1.33 and -16.6 ± 1.21 mV; loading capacity of 39.31 ± 3.7, 38.91 ± 3.6 and 40.61 ± 3.6% and entrapment efficiency of 84.63 ± 4.2, 84.71 ± 3.99 and 85.73 ± 4.31%, respectively. Ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectroscopy based bioanalytical method was developed and validated for pharmacokinetics, biodistribution, brain-targeting efficiency and brain drug-targeting potential studies post-intranasal (i.n.) administration which showed enhanced bioavailability of curcuminoids in brain as compared to intravenous administration. Improved neurobehavioural activity (locomotor and grip strength) and reduced cytokines levels (TNF-α and IL-1β) was observed in middle cerebral artery occlusion induced cerebral ischemic rats after i.n. administration of curcuminoids NPs. Finally, the toxicity study was performed which revealed safe nature of developed NPs.

  4. Molecular diagnosis of coenzyme Q10 deficiency.

    Science.gov (United States)

    Yubero, Delia; Montero, Raquel; Armstrong, Judith; Espinós, Carmen; Palau, Francesc; Santos-Ocaña, Carlos; Salviati, Leonardo; Navas, Placido; Artuch, Rafael

    2015-01-01

    Coenzyme Q10 (CoQ) deficiency syndromes comprise a growing number of neurological and extraneurological disorders. Primary-genetic but also secondary CoQ deficiencies have been reported. The biochemical determination of CoQ is a good tool for the rapid identification of CoQ deficiencies but does not allow the selection of candidate genes for molecular diagnosis. Moreover, the metabolic pathway for CoQ synthesis is an intricate and not well-understood process, where a large number of genes are implicated. Thus, only next-generation sequencing techniques (either genetic panels of whole-exome and -genome sequencing) are at present appropriate for a rapid and realistic molecular diagnosis of these syndromes. The potential treatability of CoQ deficiency strongly supports the necessity of a rapid molecular characterization of patients, since primary CoQ deficiencies may respond well to CoQ treatment.

  5. Q?

    African Journals Online (AJOL)

    Arsenic concentrations in undistributcd soils range lrom (H to ')7ing/kg (Shacltlcttc ... acid rain cause leaching ot' heavy metals to sediments and suspension in the water .... Environmental Metal Poisoning, Environmental. Pollution 50, 139-161.

  6. q-deformed harmonic and Clifford analysis and the q-Hermite and Laguerre polynomials

    CERN Document Server

    Coulembier, Kevin

    2010-01-01

    We define a q-deformation of the Dirac operator, inspired by the one dimensional q-derivative. This implies a q-deformation of the partial derivatives. By taking the square of this Dirac operator we find a q-deformation of the Laplace operator. This allows to construct q-deformed Schroedinger equations in higher dimensions. The equivalence of these Schroedinger equations with those defined on q-Euclidean space in quantum variables is shown. We also define the m-dimensional q-Clifford-Hermite polynomials and show their connection with the q-Laguerre polynomials. These polynomials are orthogonal with respect to an m-dimensional q-integration, which is related to integration on q-Euclidean space. The q-Laguerre polynomials are the eigenvectors of an su_q(1|1)-representation.

  7. Distributed Cooperative Q-learning for Power Allocation in Cognitive Femtocell Networks

    CERN Document Server

    Saad, Hussein; ElBatt, Tamer

    2012-01-01

    In this paper, we propose a distributed reinforcement learning (RL) technique called distributed power control using Q-learning (DPC-Q) to manage the interference caused by the femtocells on macro-users in the downlink. The DPC-Q leverages Q-Learning to identify the sub-optimal pattern of power allocation, which strives to maximize femtocell capacity, while guaranteeing macrocell capacity level in an underlay cognitive setting. We propose two different approaches for the DPC-Q algorithm: namely, independent, and cooperative. In the former, femtocells learn independently from each other while in the latter, femtocells share some information during learning in order to enhance their performance. Simulation results show that the independent approach is capable of mitigating the interference generated by the femtocells on macro-users. Moreover, the results show that cooperation enhances the performance of the femtocells in terms of speed of convergence, fairness and aggregate femtocell capacity.

  8. Unification of integrable q-difference equations

    Directory of Open Access Journals (Sweden)

    Burcu Silindir

    2015-10-01

    Full Text Available This article presents a unifying framework for q-discrete equations. We introduce a generalized q-difference equation in Hirota bilinear form and develop the associated three-q-soliton solutions which are described in polynomials of power functions by utilizing Hirota direct method. Furthermore, we present that the generalized q-difference soliton equation reduces to q-analogues of Toda, KdV and sine-Gordon equations equipped with their three-q-soliton solutions by appropriate

  9. Chromosome alterations in breast carcinomas: frequent involvement of DNA losses including chromosomes 4q and 21q.

    OpenAIRE

    Schwendel, A.; Richard, F.; Langreck, H.; Kaufmann, O.; Lage, H.; Winzer, K.J.; Petersen, I; Dietel, M

    1998-01-01

    Comparative genomic hybridization was applied to map DNA gains and losses in 39 invasive ductal breast carcinomas. Frequent abnormalities included gains on chromosomal regions 1q, 8q, 11q12-13, 16p, 19, 20q and X as well as frequent losses on 1p, 5q, 6q, 9p, 11q, 13q and 16q. Furthermore, frequent losses on 4q (20 cases) and 21q (14 cases) were found for the first time in this tumour type. High copy number amplifications were observed at 8q12-24, 11q11-13 and 20q13-ter. Highly differentiated ...

  10. Protective effect of Co-enzyme Q10 On doxorubicin-induced cardiomyopathy of rat hearts.

    Science.gov (United States)

    Chen, Pei-Yu; Hou, Chien-Wen; Shibu, Marthandam Asokan; Day, Cecilia Hsuan; Pai, Peiying; Liu, Zhao-Rong; Lin, Tze-Yi; Viswanadha, Vijaya Padma; Kuo, Chia-Hua; Huang, Chih-Yang

    2017-02-01

    Q10 is a powerful antioxidant often used in medical nutritional supplements for cancer treatment. This study determined whether Q10 could effectively prevent cardio-toxicity caused by doxorubicin treatment. Four week old SD rats were segregated into groups namely control, doxorubicin group (challenged with doxorubicin), Dox + Q10 group (with doxorubicin challenge and oral Q10 treatment), and Q10 group (with oral Q10 treatment). Doxorubicin groups received IP doxorubicin (2.5 mg/kg) every 3 days and Q10 groups received Q10 (10 mg/kg) every day. Three weeks of doxorubicin challenge caused significant reduction in heart weight, disarray in cardiomyocyte arrangement, elevation of collagen accumulation, enhancement of fibrosis and cell death associated proteins, and inhibition of survival proteins. However, Q10 effectively protected cardiomyocytes and ameliorated fibrosis and cell death induced by doxorubicin. Q10 is, therefore, evidently a potential drug to prevent heart damage caused by doxorubicin. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 679-689, 2017. © 2016 Wiley Periodicals, Inc.

  11. A stationary q-metric

    CERN Document Server

    Toktarbay, Saken

    2015-01-01

    We present a stationary generalization of the static $q-$metric, the simplest generalization of the Schwarzschild solution that contains a quadrupole parameter. It possesses three independent parameters that are related to the mass, quadrupole moment and angular momentum. We investigate the geometric and physical properties of this exact solution of Einstein's vacuum equations, and show that it can be used to describe the exterior gravitational field of rotating, axially symmetric, compact objects.

  12. A stationary q-metric

    Science.gov (United States)

    Toktarbay, S.; Quevedo, H.

    2014-10-01

    We present a stationary generalization of the static $q-$metric, the simplest generalization of the Schwarzschild solution that contains a quadrupole parameter. It possesses three independent parameters that are related to the mass, quadrupole moment and angular momentum. We investigate the geometric and physical properties of this exact solution of Einstein's vacuum equations, and show that it can be used to describe the exterior gravitational field of rotating, axially symmetric, compact objects.

  13. Electrochemistry of Q-graphene.

    Science.gov (United States)

    Randviir, Edward P; Brownson, Dale A C; Gómez-Mingot, Maria; Kampouris, Dimitrios K; Iniesta, Jesús; Banks, Craig E

    2012-10-21

    A newly synthesised type of graphene, Q-Graphene, has been physically and electrochemically characterised with Scanning and Transmission Electron Microscopy (SEM, TEM), X-ray Photoelectron Spectroscopy (XPS) and Cyclic Voltammetry (CV). Interpretation of SEM, TEM and XPS data reveal the material to consist of hollow carbon nanospheres of multi-layer graphene (viz. graphite), which exhibit a total oxygen content of ca. 36.0% (atomic weight via XPS). In addition to the carbon structures present, spherical magnesium oxide particles of ≤50 nm in diameter are abundantly present in the sample (ca. 16.2%). Interestingly, although the TEM/SEM images show macroporous carbon structures, Raman spectroscopy shows peaks typically characteristic of graphene, which suggests the material is highly heterogeneous and consists of many types of carbon allotropes. Q-Graphene is electrochemically characterised using both inner-sphere and outer-sphere electrochemical redox probes, namely potassium ferrocyanide(II), hexaammine-ruthenium(III) chloride and hexachloroiridate(III), in addition to the biologically relevant and electroactive analytes, norepinephrine, β-nicotinamide adenine dinucleotide (NADH) and l-ascorbic acid. The electrochemical response of Q-Graphene is benchmarked against edge plane- and basal plane-pyrolytic graphite (EPPG and BPPG respectively), pristine graphene and graphite alternatives. Q-Graphene is found to exhibit fast electron transfer kinetics, likely due to its high proportion of folded edges and surface defects, exhibiting a response similar to that of EPPG - which exhibits fast electron transfer rates due to the high proportion of edge plane sites it possesses. Furthermore, we demonstrate that the specific oxygen content plays a pivotal role in dictating the observed electrochemical response, which is analyte dependant. Consequently there is potential for this new member of the graphene family to be beneficially utilised in various electrochemical

  14. Combination therapy with metformin and coenzyme Q10 in murine experimental autoimmune arthritis.

    Science.gov (United States)

    Jhun, JooYeon; Lee, SeungHoon; Kim, Se-Young; Na, Hyun Sik; Kim, Eun-Kyung; Kim, Jae-Kyung; Jeong, Jeong-Hee; Park, Sung Hwan; Cho, Mi-La

    2016-01-01

    Metformin (Met) and coenzyme Q10 (CoQ10) are reported to have therapeutic functions in several inflammatory diseases. These drugs have shown anti-inflammatory effects and have been utilized in mouse models of rheumatoid arthritis (RA). However, there is no evidence of the additive effect of Met and CoQ10 in RA. Although Met and CoQ10 may be involved in the improvement of mitochondrial dysfunction, limited information is available regarding whether this effect can improve mitochondrial dysfunction in RA in particular. In this study, we sought to determine whether Met and CoQ10 attenuate the severity of collagen-induced arthritis (CIA) and show an additive effect in a mouse model. The combination of Met and CoQ10 improved CIA, reducing joint inflammation, Th17 differentiation and IgG production. In contrast, the combination of Met and CoQ10 induced Treg differentiation. Osteoclastogenesis was reduced by the combination of Met and CoQ10. The protein expression of interleukin-1β, interleukin-6 and tumor necrosis factor-alpha in mice splenocytes exposed to lipopolysaccharide decreased after drug combination therapy. We also found that the expression of JC-1 and COX IV were enhanced by treatment with the combination of Met and CoQ10. Moreover, the combination of Met and CoQ10 promoted mitochondrial O2 consumption. These findings suggest that the combination of Met and CoQ10 reduced CIA severity, improving mitochondrial dysfunction compared to Met or CoQ10 alone. These results present a novel, significant preventive targets in RA and may enhance our understanding of its pathogenesis.

  15. Triply heavy tetraquark states with the QQ anti Q anti q configuration

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Kan; Liu, Xiang [Lanzhou University, School of Physical Science and Technology, Lanzhou (China); Lanzhou University and Institute of Modern Physics of CAS, Research Center for Hadron and CSR Physics, Lanzhou (China); Liu, Yan-Rui; Wu, Jing [Shandong University, School of Physics and Key Laboratory of Particle Physics and Particle Irradiation (MOE), Jinan (China); Zhu, Shi-Lin [Peking University, School of Physics and State Key Laboratory of Nuclear Physics and Technology, Beijing (China); Collaborative Innovation Center of Quantum Matter, Beijing (China); Peking University, Center of High Energy Physics, Beijing (China)

    2017-01-15

    In the framework of the color-magnetic interaction, we systematically investigate the mass splittings of the QQ anti Q anti q tetraquark states and estimate their rough masses in this work. These systems include the explicitly exotic states cc anti b anti q and bb anti c anti q and the hidden exotic states cc anti c anti q, cb anti b anti q, bc anti c anti q, and bb anti b anti q. If a state around the estimated mass region can be observed, its nature as a genuine tetraquark is favored. The strong decay patterns shown here will be helpful to the experimental search for these exotic states. (orig.)

  16. I-Love-Q forever

    CERN Document Server

    Maselli, Andrea; Ferrari, Valeria; Gualtieri, Leonardo; Pani, Paolo

    2013-01-01

    Neutron stars are extremely relativistic objects which abound in our universe and yet are poorly understood, due to the high uncertainty on how matter behaves in the extreme conditions which prevail in the stellar core. It has recently been pointed out that the moment of inertia I, the Love number lambda and the spin-induced quadrupole moment Q of an isolated neutron star, are related through functions which are practically independent of the equation of state. These surprising universal I-lambda-Q relations pave the way for a better understanding of neutron stars, most notably via gravitational-wave emission. Gravitational-wave observations will probe highly-dynamical binaries and it is important to understand whether the universality of the I-lambda-Q relations survive strong-field and finite-size effects. We apply a Post-Newtonian-Affine approach to model tidal deformations in compact binaries and show that the I-lambda relation depends on the inspiral frequency, but is insensitive to the equation of state...

  17. Partial 1q Duplications and Associated Phenotype

    Science.gov (United States)

    Morris, Marcos L.M.; Baroneza, José E.; Teixeira, Patricia; Medina, Cristina T.N.; Cordoba, Mara S.; Versiani, Beatriz R.; Roese, Liege L.; Freitas, Erika L.; Fonseca, Ana C.S.; dos Santos, Maria C.G.; Pic-Taylor, Aline; Rosenberg, Carla; Oliveira, Silviene F.; Ferrari, Iris; Mazzeu, Juliana F.

    2016-01-01

    Duplications of the long arm of chromosome 1 are rare. Distal duplications are the most common and have been reported as either pure trisomy or unbalanced translocations. The paucity of cases with pure distal 1q duplications has made it difficult to delineate a partial distal trisomy 1q syndrome. Here, we report 2 patients with overlapping 1q duplications detected by G-banding. Array CGH and FISH were performed to characterize the duplicated segments, exclude the involvement of other chromosomes and determine the orientation of the duplication. Patient 1 presents with a mild phenotype and carries a 22.5-Mb 1q41q43 duplication. Patient 2 presents with a pure 1q42.13qter inverted duplication of 21.5 Mb, one of the smallest distal 1q duplications ever described and one of the few cases characterized by array CGH, thus contributing to a better characterization of distal 1q duplication syndrome. PMID:27022331

  18. Supersymmetric q-deformed quantum mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Traikia, M. H.; Mebarki, N. [Laboratoire de Physique Mathematique et Subatomique, Mentouri University, Constantine (Algeria)

    2012-06-27

    A supersymmetric q-deformed quantum mechanics is studied in the weak deformation approximation of the Weyl-Heisenberg algebra. The corresponding supersymmetric q-deformed hamiltonians and charges are constructed explicitly.

  19. Pisot-Fibonacci q-coherent states

    Energy Technology Data Exchange (ETDEWEB)

    Gazeau, Jean Pierre [Laboratoire APC, Universite Paris Diderot Paris 7, 10 rue A. Domon et L. Duquet, 75205 Paris Cedex 13 (France); Olmo, Mariano A del, E-mail: gazeau@apc.univ-paris7.fr, E-mail: olmo@fta.uva.es [Departamento de Fisica Teorica, Universidad de Valladolid, E-47005, Valladolid (Spain)

    2011-03-01

    A family of q-coherent states is constructed allowing us to obtain a new quantized version of the harmonic oscillator. These q-states are normalized and form an overcomplete set resolving the unity with respect to the appropriate Jackson measure if 0 < q < 1. We only consider here those values of q such that q{sup -1} is a Pisot number. In this case the q-deformed integers ([n]{sub q}) form Fibonacci-like sequences of integers. We study the main physical characteristics of the corresponding quantum oscillator: localization in the configuration and in the phase spaces, probability distributions and related statistical features and semi-classical phase space trajectories whose periodicity is related with the fact that q is an algebraic number.

  20. QTL Information Table: 30 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qUVR-10 Resistance or Tolerance Other stress resistance ultraviolet-B (UVB) resista... and Yano, M. (2004). Delimitation of the chromosomal region for a quantitative trait locus, qUVR- 10, conferring resistance to ultra

  1. Minimum Data Set Q1a Report

    Data.gov (United States)

    U.S. Department of Health & Human Services — The MDS Q1a report summarizes, by state and county, percentages of residents that answered Yes to Q1a - Residents expresses or indicates preference to return to the...

  2. Functional differential equations for the q-Fourier transform of q-Gaussians

    Energy Technology Data Exchange (ETDEWEB)

    Umarov, S [Department of Mathematics, Tufts University, Medford, MA (United States); Queiros, S M Duarte, E-mail: sdqueiro@gmail.co [Unilever R and D Port Sunlight, Quarry Road East, Wirral, CH63 3JW (United Kingdom)

    2010-02-05

    In this paper the question 'is the q-Fourier transform of a q-Gaussian a q'-Gaussian (with some q') up to a constant factor?' is studied for the whole range of q in (- infty, 3). This question is connected with applicability of the q-Fourier transform in the study of limit processes in nonextensive statistical mechanics. Using the functional differential equation approach we prove that the answer is affirmative if and only if 1 <= q < 3, excluding two particular cases of q < 1, namely q=1/2 and q=2/3. Complementarily, we discuss some applications of the q-Fourier transform to nonlinear partial differential equations such as the porous medium equation.

  3. q-deformed harmonic and Clifford analysis and the q-Hermite and Laguerre polynomials

    Science.gov (United States)

    Coulembier, K.; Sommen, F.

    2010-03-01

    We define a q-deformation of the Dirac operator, inspired by the one-dimensional q-derivative. This implies a q-deformation of the partial derivatives. By taking the square of this Dirac operator we find a q-deformation of the Laplace operator. This allows us to construct q-deformed Schrödinger equations in higher dimensions. The equivalence of these Schrödinger equations with those defined on q-Euclidean space in quantum variables is shown. We also define the m-dimensional q-Clifford-Hermite polynomials and show their connection with the q-Laguerre polynomials. These polynomials are orthogonal with respect to an m-dimensional q-integration, which is related to integration on q-Euclidean space. The q-Laguerre polynomials are the eigenvectors of an suq(1|1)-representation.

  4. q-Integration on Quantum Spaces

    OpenAIRE

    Wachter, Hartmut

    2002-01-01

    In this article we present formulae for q-integration on quantum spaces which could be of particular importance in physics, i.e. q-deformed Minkowski space and q-deformed Euclidean space in 3 or 4 dimensions. Furthermore, our formulae can be regarded as a generalization of Jackson's q-integral to 3 and 4 dimensions and provide a new possibility for an integration over the whole space being invariant under translations and rotations.

  5. q-Integration on quantum spaces

    Energy Technology Data Exchange (ETDEWEB)

    Wachter, H. [Sektion Physik, Ludwig-Maximilians-Universitaet, Theresienstr. 37, 80333, Muenchen (Germany)

    2004-01-01

    In this article we present explicit formulae for q-integration on quantum spaces which could be of particular importance in physics, i.e., q-deformed Minkowski space and q-deformed Euclidean space in three or four dimensions. Furthermore, our formulae can be regarded as a generalization of Jackson's q-integral to three or four dimensions and provide a new possibility for an integration over the whole space being invariant under translations and rotations. (orig.)

  6. The immune response in Q fever

    NARCIS (Netherlands)

    Schoffelen, T.

    2015-01-01

    Q fever is an infection caused by the bacterium Coxiella burnetii. A large outbreak of Q fever occurred in the Netherlands between 2007 and 2010, in which infected goats and sheep were the source of human infections. In some people, so-called ‘chronic Q fever’ develops, which mainly manifests as end

  7. Heavy-quark symmetry implies stable heavy tetraquark mesons $Q_iQ_j \\bar q_k \\bar q_l$

    Energy Technology Data Exchange (ETDEWEB)

    Eichten, Estia J.; Quigg, Chris

    2017-07-29

    For very heavy quarks $Q$, relations derived from heavy-quark symmetry predict the existence of novel narrow doubly heavy tetraquark states of the form $Q_iQ_j \\bar q_k \\bar q_l$ (subscripts label flavors), where $q$ designates a light quark. By evaluating finite-mass corrections, we predict that double-beauty states composed of $bb\\bar u \\bar d$, $bb\\bar u \\bar s$, and $bb\\bar d \\bar s$ will be stable against strong decays, whereas the double-charm states $cc \\bar q_k \\bar q_l$, mixed beauty+charm states $bc \\bar q_k \\bar q_l$, and heavier $bb \\bar q_k \\bar q_l$ states will dissociate into pairs of heavy-light mesons. Observation of a new double-beauty state through its weak decays would establish the existence of tetraquarks and illuminate the role of heavy color-antitriplet diquarks as hadron constituents.

  8. q-exchangeability via quasi-invariance

    NARCIS (Netherlands)

    Gnedin, A.V.; Olshanski, G.

    2010-01-01

    For positive q is not 1, the q-exchangeability of an infinite random word is introduced as quasi-invariance under permutations of letters, with a special cocycle which accounts for inversions in the word. This framework allows us to extend the q-analog of de Finetti’s theorem for binary sequences—se

  9. Speeding Up Q(lambda)-learning

    NARCIS (Netherlands)

    Wiering, M.A.; Schmidhuber, J.

    1998-01-01

    Q(lambda)-learning uses TD(lambda)-methods to accelerate Q learning. The worst case complexity for a single update step of previous online Q(lambda)implementations based on lookup tables is bounded by the size of the state action space. Our faster algorithm's worst case complexity is bounded by the

  10. The immune response in Q fever

    NARCIS (Netherlands)

    Schoffelen, T.

    2015-01-01

    Q fever is an infection caused by the bacterium Coxiella burnetii. A large outbreak of Q fever occurred in the Netherlands between 2007 and 2010, in which infected goats and sheep were the source of human infections. In some people, so-called ‘chronic Q fever’ develops, which mainly manifests as

  11. QTL Information Table: 772 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qGT-6 Physiological trait Eating quality Gelatinization temperature SSR C)Interval DHL Wuyuji...ng 2 Zhenshan 97B A RM276 RM121 pha Tian, R., Jiang, G.-H., Shen, L.-H., Wang, L.-Q., and He, Y.-Q

  12. QTL Information Table: 774 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qCRE-6 Physiological trait Eating quality cooked rice elongation SSR C)Interval DHL Wuyuji...ng 2 Zhenshan 97B A RM170 RM190 pha Tian, R., Jiang, G.-H., Shen, L.-H., Wang, L.-Q., and He, Y.-Q. (

  13. QTL Information Table: 321 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qCR-3 Physiological trait Source activity chlorophyll a/b ratio RFLP C)Interval RIL... Kinmaze DV85 B C25 R518 rgn Hu, M.L., Wang, C.M., Yang, Q.H., Zhai, H.Q., and Wan, J.M. (2004). QTL analysis for trait

  14. QTL Information Table: 322 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qCC-1 Physiological trait Source activity chlorophyll content of leaf RFLP C)Interv...al RIL Kinmaze DV85 B C122 R1012 rgn Hu, M.L., Wang, C.M., Yang, Q.H., Zhai, H.Q., and Wan, J.M. (2004). QTL analysis for trait

  15. Q Methodology, Communication, and the Behavioral Text.

    Science.gov (United States)

    McKeown, Bruce

    1990-01-01

    Discusses Q methodology in light of modern philosophy of science and hermeneutics. Outlines and discusses the basic steps of conducting Q-method research. Suggests that Q methodology allows researchers to understand and interpret the subjective text of respondents without confounding them with external categories of theoretical reflection. (RS)

  16. Overexpression of a Chloroplast-located Peroxiredoxin Q Gene, SsPrxQ, Increases the Salt and Low-temperature Tolerance of Arabidopsis

    Institute of Scientific and Technical Information of China (English)

    Li-Wen Jing; Shi-Hua Chen; Xiao-Li Guo; Hui Zhang; Yan-Xiu Zhao

    2006-01-01

    Abiotic stress, such as salt, drought and extreme temperature,can result in enhanced production of reactive oxygen species (ROS). Plants have developed both enzymatic ROS-scavenging and non-enzymatic ROS-scavenging systems. The major ROS-scavenging enzymes of plants include superoxide dismutase (SOD), ascorbate peroxidase (APX), catalase (CAT), glutathione peroxidase (GPX) and peroxiredoxins (Prxs). In the present work, we identified a gene encoding chloroplast-located peroxiredoxin Q, SsPrxQ, from Suaeda salsa L. Located at chloroplast. Overexpression of SsPrxQ in Arabidopsis leads to an increase in salt and low-temperature tolerance.

  17. Differential regulation of Aβ42-induced neuronal C1q synthesis and microglial activation

    Directory of Open Access Journals (Sweden)

    Tenner Andrea J

    2005-01-01

    Full Text Available Abstract Expression of C1q, an early component of the classical complement pathway, has been shown to be induced in neurons in hippocampal slices, following accumulation of exogenous Aβ42. Microglial activation was also detected by surface marker expression and cytokine production. To determine whether C1q induction was correlated with intraneuronal Aβ and/or microglial activation, D-(--2-amino-5-phosphonovaleric acid (APV, an NMDA receptor antagonist and glycine-arginine-glycine-aspartic acid-serine-proline peptide (RGD, an integrin receptor antagonist, which blocks and enhances Aβ42 uptake, respectively, were assessed for their effect on neuronal C1q synthesis and microglial activation. APV inhibited, and RGD enhanced, microglial activation and neuronal C1q expression. However, addition of Aβ10–20 to slice cultures significantly reduced Aβ42 uptake and microglial activation, but did not alter the Aβ42-induced neuronal C1q expression. Furthermore, Aβ10–20 alone triggered C1q production in neurons, demonstrating that neither neuronal Aβ42 accumulation, nor microglial activation is required for neuronal C1q upregulation. These data are compatible with the hypothesis that multiple receptors are involved in Aβ injury and signaling in neurons. Some lead to neuronal C1q induction, whereas other(s lead to intraneuronal accumulation of Aβ and/or stimulation of microglia.

  18. Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22.

    Directory of Open Access Journals (Sweden)

    Mine S Cicek

    Full Text Available A substantial proportion of familial colorectal cancer (CRC is not a consequence of known susceptibility loci, such as mismatch repair (MMR genes, supporting the existence of additional loci. To identify novel CRC loci, we conducted a genome-wide linkage scan in 356 white families with no evidence of defective MMR (i.e., no loss of tumor expression of MMR proteins, no microsatellite instability (MSI-high tumors, or no evidence of linkage to MMR genes. Families were ascertained via the Colon Cancer Family Registry multi-site NCI-supported consortium (Colon CFR, the City of Hope Comprehensive Cancer Center, and Memorial University of Newfoundland. A total of 1,612 individuals (average 5.0 per family including 2.2 affected were genotyped using genome-wide single nucleotide polymorphism linkage arrays; parametric and non-parametric linkage analysis used MERLIN in a priori-defined family groups. Five lod scores greater than 3.0 were observed assuming heterogeneity. The greatest were among families with mean age of diagnosis less than 50 years at 4q21.1 (dominant HLOD = 4.51, α = 0.84, 145.40 cM, rs10518142 and among all families at 12q24.32 (dominant HLOD = 3.60, α = 0.48, 285.15 cM, rs952093. Among families with four or more affected individuals and among clinic-based families, a common peak was observed at 15q22.31 (101.40 cM, rs1477798; dominant HLOD = 3.07, α = 0.29; dominant HLOD = 3.03, α = 0.32, respectively. Analysis of families with only two affected individuals yielded a peak at 8q13.2 (recessive HLOD = 3.02, α = 0.51, 132.52 cM, rs1319036. These previously unreported linkage peaks demonstrate the continued utility of family-based data in complex traits and suggest that new CRC risk alleles remain to be elucidated.

  19. PREDUAL SPACES FOR Q SPACES

    Institute of Scientific and Technical Information of China (English)

    Peng Lizhong; Yang Qixiang

    2009-01-01

    To find the predual spaces PαRn) of QαRn) is an important motivation in the study of Q spaces. In this article, wavelet methods are used to solve this problem in a constructive way. First, an wavelet tent atomic characterization of PαRn) is given, then its usual atomic characterization and Poisson extension characterization are given. Finally, the continuity on Pαof Calderón-Zygmund operators is studied, and the result can be also applied to give the Morrey characterization of PαRn).

  20. Bogoliubov q-transformation and Clebsch-Gordan coefficients for a q-oscillator

    Science.gov (United States)

    Zhedanov, A. S.

    1992-05-01

    The q-analog of the Bogoliubov transformation is found, yielding the third q-Bose operator from the two independent ones. In contrast to the ordinary case, this transformation is non-linear. Considered as a co-multiplication for the q-oscillator algebra, this transformation generates the Clebsch-Gordan series with coefficients expressed via the Kravchuk q-polynomials.

  1. A characterization of the desarguesian planes of order q2 by SL(2,q

    Directory of Open Access Journals (Sweden)

    D. A. Foulser

    1983-01-01

    Full Text Available The main result is that if the translation complement of a translation plane of order q2 contains a group isomorphic to SL(2,q and if the subgroups of order q are elations (shears, then the plane is Desarguesian. This generalizes earlier work of Walker, who assumed that the kernel of the plane contained GF(q.

  2. Analysis of the radiative decays $\\Sigma_Q \\to \\Lambda_Q \\gamma$ and $\\Xi^\\prime_Q \\to \\Xi_Q \\gamma$ in light cone sum rules

    CERN Document Server

    Aliev, T M; Savcı, M

    2016-01-01

    The light cone sum rules method is used in studying the radiative decays $\\Sigma_Q \\to \\Lambda_Q \\gamma$ and $\\Xi^\\prime_Q \\to \\Xi_Q \\gamma$. Firstly, the sum rules for the form factor $F_2(Q^2=0)$ responsible for these transitions is constructed. Using this result the decay widths of the above--mentioned decays are calculated and analyzed. A comparison of our predictions on the decay widths of considered transitions with the predictions of the other approaches is presented.

  3. Partial trisomy 4q: a case report

    Institute of Scientific and Technical Information of China (English)

    CUI Ying-xia; WANG Yun-hua; HAO Li-jun; HOU Lin; LI Wei; HUANG Yun-feng

    2006-01-01

    @@ The clinical findings frequently presented in trisomy 4q syndrome including mental retardation, developmental delay and multiple abnormalities such as microcephaly, acrocephaly, as well as malformed ears, high/broad/depressed nasal bridge, teeth and thumb anomalies. It has been proposed that trisomy 4q is caused by a familial balanced translocation or a de novo imbalance. We reported a new case of trisomy 4q with a karyotype of 46, XY, der(5)t(4;5)(q27;q35) and this karyotye was reported for the first time.

  4. On q-Difference Riccati Equations and Second-Order Linear q-Difference Equations

    Directory of Open Access Journals (Sweden)

    Zhi-Bo Huang

    2013-01-01

    Full Text Available We consider q-difference Riccati equations and second-order linear q-difference equations in the complex plane. We present some basic properties, such as the transformations between these two equations, the representations and the value distribution of meromorphic solutions of q-difference Riccati equations, and the q-Casorati determinant of meromorphic solutions of second-order linear q-difference equations. In particular, we find that the meromorphic solutions of these two equations are concerned with the q-Gamma function when q∈ℂ such that 0<|q|<1. Some examples are also listed to illustrate our results.

  5. The Q-angle and sport

    DEFF Research Database (Denmark)

    Hahn, Thomas; Foldspang, Anders

    1997-01-01

    Quadriceps muscle contraction tends to straighten the Q angle. We expected that sports comprising a high amount of quadriceps training could be associated with low Q angles. The aim of the present study was to estimate the Q angle in athletes and to investigate its potential associations with par......Quadriceps muscle contraction tends to straighten the Q angle. We expected that sports comprising a high amount of quadriceps training could be associated with low Q angles. The aim of the present study was to estimate the Q angle in athletes and to investigate its potential associations...... with participation in sport. Three hundred and thirty-nine athletes had their Q angle measured. The mean of right-side Q angles was higher than left side, and the mean Q angle was higher in women than in men. The Q angle was positively associated with years of jogging, and negatively with years of soccer, swimming...... and sports participation at all. It is concluded that the use of Q angle measurements is questionable....

  6. On q-n-gonal Klein Surfaces

    Institute of Scientific and Technical Information of China (English)

    B. ESTRADA; R. A. HIDALGO; E.MARTINEZ

    2007-01-01

    We consider proper Klein surfaces X of algebraic genus p≥2, having an automorphismφ of prime order n with quotient space X/〈φ〉 of algebraic genus q. These Klein surfaces axe calledq-n-gonal surfaces and they axe n-sheeted covers of surfaces of algebraic genus q. In this paper weextend the results of the already studied cases n ≤3 to this more general situation. Given p≥2, weobtain, for each prime n, the (admissible) values q for which there exists a q-n-gonal surface of algebraicgenus p. Furthermore, for each p and for each admissible q, it is possible to check all topological typesof q-n-gonal surfaces with algebraic genus p. Several examples are given: q-pentagonal surfaces andq-n-gonal bordered surfaces with topological genus g = 0,1.

  7. New results on q-positivity

    CERN Document Server

    Ramos, Y García; Simons, S

    2011-01-01

    In this paper we discuss symmetrically self-dual spaces, which are simply real vector spaces with a symmetric bilinear form. Certain subsets of the space will be called q-positive, where q is the quadratic form induced by the original bilinear form. The notion of q-positivity generalizes the classical notion of the monotonicity of a subset of a product of a Banach space and its dual. Maximal q-positivity then generalizes maximal monotonicity. We discuss concepts generalizing the representations of monotone sets by convex functions, as well as the number of maximally q-positive extensions of a q-positive set. We also discuss symmetrically self-dual Banach spaces, in which we add a Banach space structure, giving new characterizations of maximal q-positivity. The paper finishes with two new examples.

  8. Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation.

    Science.gov (United States)

    Gomez, Fernando; Saiki, Ryoichi; Chin, Randall; Srinivasan, Chandra; Clarke, Catherine F

    2012-09-10

    Coenzyme Q (ubiquinone or Q) is an essential lipid component of the mitochondrial electron transport chain. In Caenorhabditis elegans Q biosynthesis involves at least nine steps, including the hydroxylation of the hydroquinone ring by CLK-1 and two O-methylation steps mediated by COQ-3. We characterize two C. elegans coq-3 deletion mutants, and show that while each has defects in Q synthesis, their phenotypes are distinct. First generation homozygous coq-3(ok506) mutants are fertile when fed the standard lab diet of Q-replete OP50 Escherichia coli, but their second generation homozygous progeny does not reproduce. In contrast, the coq-3(qm188) deletion mutant remains sterile when fed Q-replete OP50. Quantitative PCR analyses suggest that the longer qm188 deletion may alter expression of the flanking nuo-3 and gdi-1 genes, located 5' and 3', respectively of coq-3 within an operon. We surmise that variable expression of nuo-3, a subunit of complex I, or of gdi-1, a guanine nucleotide dissociation inhibitor, may act in combination with defects in Q biosynthesis to produce a more severe phenotype. The phenotypes of both coq-3 mutants are more drastic as compared to the C. elegans clk-1 mutants. When fed OP50, clk-1 mutants reproduce for many generations, but show reduced fertility, slow behaviors, and enhanced life span. The coq-3 and clk-1 mutants all show arrested development and are sterile when fed the Q-deficient E. coli strain GD1 (harboring a mutation in the ubiG gene). However, unlike clk-1 mutant worms, neither coq-3 mutant strain responded to dietary supplementation with purified exogenous Q(10). Here we show that the Q(9) content can be determined in lipid extracts from just 200 individual worms, enabling the determination of Q content in the coq-3 mutants unable to reproduce. An extra-chromosomal array expressing wild-type C. elegans coq-3 rescued fertility of both coq-3 mutants and partially restored steady-state levels of COQ-3 polypeptide and Q(9

  9. Maternal uniparental disomy of chromosome 14 in a boy with t(14q14q) associated with a paternal t(13q14q)

    Energy Technology Data Exchange (ETDEWEB)

    Tomkins, D.J.; Waye, J.S.; Whelan, D.T. [McMaster Univ., Ontario (Canada)] [and others

    1994-09-01

    An 11-year-old boy was referred for chromosomal analysis because of precocious development and behavioral problems suggestive of the fragile X syndrome. The cytogenetic fragile X studies were normal, but a routine GTG-banded karyotype revealed an abnormal male karyotype with a Robertsonian translocation between the two chromosome 14`s: 46,XY,t(14q14q). Paternal karyotyping revealed another abnormal karyotype: 46,XY,t(13q14q). A brother had the same karyotype as the father; the mother was deceased. In order to determine if the apparently balanced t(14q14q) in the proband might be the cause of the clinical findings, molecular analysis of the origin of the chromosome 14`s was initiated. Southern blotting and hybridization with D4S13 showed that the proband had two copies of one maternal allele which was shared by his brother. The brother`s second allele corresponded to one of the paternal alleles; the proband had no alleles from the father. Analysis of four other VNTRs demonstrated the probability of paternity to be greater than 99%. Thus, the t(14q14q) was most likely composed of two maternal chromosome 14`s. Further characterization of the t(14q14q) by dinucleotide repeat polymorphic markers is in progress to determine whether it has arisen from maternal isodisomy or heterodisomy. Several cases of uniparental disomy for chromosome 14 have been reported recently. Paternal disomy appears to be associated with more severe congenital anomalies and mental retardation, whereas maternal disomy may be associated with premature puberty and minimal intellectual impairment. The origin of the t(14q14q) in the present case may be related to the paternal translocation, as the segregation of the t(13q14q) in meiosis could lead to sperm that are nullisomic for chromosome 14.

  10. Sl$_{q}$(2) realizations for Kepler and oscillator potentials and q-canonical transformations

    CERN Document Server

    Dayi, O F; Dayi, O F; Duru, I H

    1994-01-01

    The realizations of the Lie algebra corresponding to the dynamical symmetry group SO(2,1) of the Kepler and oscillator potentials are q-deformed. The q-canonical transformation connecting two realizations is given and a general definition for q-canonical transformation is deduced. q-Schr\\"{o}dinger equation for a Kepler like potential is obtained from the q-oscillator Schr\\"{o}dinger equation. Energy spectrum and the ground state wave function are calculated.

  11. Ultra-high Q even eigenmode resonance in terahertz metamaterials

    Science.gov (United States)

    Al-Naib, Ibraheem; Yang, Yuping; Dignam, Marc M.; Zhang, Weili; Singh, Ranjan

    2015-01-01

    We report the simultaneous excitation of the odd and the even eigenmode resonances in a periodic array of square split-ring resonators, with four resonators per unit cell. When the electric field is parallel to their gaps, only the two well-studied odd eigenmodes are excited. As the resonators are rotated relative to one another, we observe the emergence and excitation of an extremely sharp even eigenmode. In uncoupled split-ring resonators, this even eigenmode is typically radiative in nature with a broad resonance linewidth and low Q-factor. However, in our coupled system, for specific range of rotation angles, our simulations revealed a remarkably high quality factor (Q ˜ 100) for this eigenmode, which has sub-radiant characteristics. This type of quad-supercell metamaterial offers the advantage of enabling access to all the three distinct resonance features of the split-ring resonator, which consists of two odd eigenmodes in addition to the high-Q even eigenmode, which could be exploited for high performance multiband filters and absorbers. The high Q even eigenmode could find applications in designing label free bio-sensors and for studying the enhanced light matter interaction effects.

  12. q-Exchangeability via quasi-invariance

    CERN Document Server

    Gnedin, Alexander

    2009-01-01

    For positive q, the q-exchangeability is introduced as quasi-invariance under permutations, with a special cocycle. This allows us to extend the q-analogue of de Finetti's theorem for binary sequences (arXiv:0905.0367) to the general real-valued sequences. In contrast to the classical case with q=1, the order on the reals plays for the q-analogues a significant role. An explicit construction of ergodic q-exchangeable measures involves a random shuffling of the set N={1,2,..} by iteration of the geometric choice. For q distinct from 1, the shuffling yields a probability measure Q that is supported by the group of bijections of N, and has the property of quasi-invariance under both left and right multiplications by finite permutations. We establish connections of the q-exchangeability to certain transient Markov chains on the q-Pascal pyramids and to invariant random flags over the Galois fields.

  13. Degenerate Series Representations of the q-Deformed Algebra $so'_q(r,s$

    Directory of Open Access Journals (Sweden)

    Valentyna A. Groza

    2007-05-01

    Full Text Available The $q$-deformed algebra ${m so}'_q(r,s$ is a realform of the $q$-deformed algebra $U'_q({m so}(n,mathbb{C}$,$n=r+s$, which dif/fers from the quantum algebra $U_q({mso}(n,mathbb{C}$ of Drinfeld and Jimbo. We study representationsof the most degenerate series of the algebra ${m so}'_q(r,s$. Theformulas of action of operators of these representations upon thebasis corresponding to restriction of representations onto thesubalgebra ${m so}'_q(rimes {m so}'_q(s$ are given. Most ofthese representations are irreducible. Reducible representationsappear under some conditions for the parameters determining therepresentations. All irreducible constituents which appear inreducible representations of the degenerate series are found. All$*$-representations of ${m so}'_q(r,s$ are separated in the setof irreducible representations obtained in the paper.

  14. A Modified Moist Ageostrophic Q Vector

    Institute of Scientific and Technical Information of China (English)

    YUE Caijun; SHOU Shaowen

    2008-01-01

    The quasi-geostrophic Q vector is an important diagnostic tool for studying development of surface rainfall associated with large-scale weather systems and is calculated using data at single vertical level. When ageostrophic Q vector was introduced, it required data at two vertical levels. In this study, moist ageostrophic Q vector is modified so that it can be calculated using data at a single vertical level. The comparison study between the original and modified moist ageostrophic Q vectors is conducted using the data from 5 to 6 July 1991 during the torrential rainfall event associated with the Changjiang-Huaihe mei-yu front in China. The results reveal that divergences of original and modified moist ageostrophic Q vectors have similar horizontal distributions and their centers are almost located in the precipitation centers. This indicates that modified moist ageostrophic Q vector can be used to diagnose convective development with reasonable accuracy.

  15. Fibroma of tendon sheath with 11q rearrangements.

    Science.gov (United States)

    Nishio, Jun; Iwasaki, Hiroshi; Nagatomo, Masaya; Naito, Masatoshi

    2014-09-01

    Fibroma of tendon sheath is an uncommon, benign fibroblastic tumor that usually occurs in the upper extremities of young and middle-aged adults. A clonal chromosomal aberration, t(2;11)(q31-32;q12), has been described in one case. We herein present a unique cytogenetic finding of fibroma of tendon sheath arising in the first web space of the right hand of a 38-year-old woman. Physical examination showed a 3.5-cm, firm, mobile, non-tender mass. Magnetic resonance imaging showed a well-defined soft tissue mass with iso- to slightly-low signal intensity relative to skeletal muscle on both T1- and T2-weighted sequences. Contrast-enhanced T1-weighted sequences demonstrated moderate patchy enhancement of the mass. A fibroma or giant cell tumor of tendon sheath was suggested, and the lesion was marginally excised. Histological examination confirmed the diagnosis of fibroma of tendon sheath. Cytogenetic analysis revealed a novel t(9;11)(p24;q13-14) translocation among other karyotypic abnormalities. The postoperative course was uneventful, and the patient is doing well without local recurrence two months after surgery. To the best of our knowledge, this is only the second report of fibroma of tendon sheath with clonal chromosomal abnormalities.

  16. Qq(-Q)(-q)'States in Chiral SU(3) Quark Model

    Institute of Scientific and Technical Information of China (English)

    ZHANG Hai-Xia; ZHANG Min; ZHANG Zong-Ye

    2007-01-01

    We study the masses of Qq(-Q)(-q)'states with JPC = 0++, 1++, 1+- and 2++ in the chiral SU(3) quark model,where Q is the heavy quark (c or b) and q (q') is the light quark (u, d or s). According to our numerical results, it is improbable to make the interpretation of [cn(-c)(-n)]1++ and [cn(-c)(-n)]2++ (n = u, d) states as X(3872) and Y(3940),respectively. However, it is interesting to find the tetraquarks in the bq(-b)(-q)'system.

  17. The tree method for multidimensional q-Hahn and q-Racah polynomials

    CERN Document Server

    Scarabotti, Fabio

    2009-01-01

    We develop a tree method for multidimensional q-Hahn polynomials. We define them as eigenfunctions of a multidimensional q-difference operator and we use the factorization of this operator as a key tool. Then we define multidimensional q-Racah polynomials as the connection coefficients between different bases of q-Hahn polynomials. We show that our multidimensional q-Racah polynomials may be expressed as product of ordinary one-dimensional q-Racah polynomial by means of a suitable sequence of transplantations of edges of the trees.

  18. Construction of normal numbers with respect to the $Q$-Cantor series expansion for certain $Q$

    CERN Document Server

    Mance, Bill

    2009-01-01

    A. Renyi \\cite{Renyi} made a definition that gives one generalization of simple normality in the context of $Q$-Cantor series. Similarly, in this paper we give a definition which generalizes the notion of normality in the context of $Q$-Cantor series. We will prove a theorem that allows us to concatenate sequences of digits that have a special property to give us the digits of a $Q$-normal number for certain $Q$. We will then use this theorem to construct a Q and a real number $x$ that is $Q$-normal.

  19. Closure of q-Quantum Languages

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    η-quantum languages are discussed and some of their properties are derived. Furthermore the q-quantum language is defined. It is shown that L (A1 (×) A2 ) =L(A1)∩L(A2), L(A) = L(A1)∪L(A2). So over the same alphabet the intersection and union of two different q-quantum languages are also q-quantum languages.

  20. Coenzyme Q10 and Neurological Diseases

    Directory of Open Access Journals (Sweden)

    Gabriele Siciliano

    2009-12-01

    Full Text Available Coenzyme Q10 (CoQ10, or ubiquinone is a small electron carrier of the mitochondrial respiratory chain with antioxidant properties. CoQ10 supplementation has been widely used for mitochondrial disorders. The rationale for using CoQ10 is very powerful when this compound is primary decreased because of defective synthesis. Primary CoQ10 deficiency is a treatable condition, so heightened “clinical awareness” about this diagnosis is essential. CoQ10 and its analogue, idebenone, have also been widely used in the treatment of other neurodegenerative disorders. These compounds could potentially play a therapeutic role in Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, Friedreich’s ataxia, and other conditions which have been linked to mitochondrial dysfunction. This article reviews the physiological roles of CoQ10, as well as the rationale and the role in clinical practice of CoQ10 supplementation in different neurological diseases, from primary CoQ10 deficiency to neurodegenerative disorders.

  1. Biochemical Assessment of Coenzyme Q10 Deficiency

    Directory of Open Access Journals (Sweden)

    Juan Carlos Rodríguez-Aguilera

    2017-03-01

    Full Text Available Coenzyme Q10 (CoQ10 deficiency syndrome includes clinically heterogeneous mitochondrial diseases that show a variety of severe and debilitating symptoms. A multiprotein complex encoded by nuclear genes carries out CoQ10 biosynthesis. Mutations in any of these genes are responsible for the primary CoQ10 deficiency, but there are also different conditions that induce secondary CoQ10 deficiency including mitochondrial DNA (mtDNA depletion and mutations in genes involved in the fatty acid β-oxidation pathway. The diagnosis of CoQ10 deficiencies is determined by the decrease of its content in skeletal muscle and/or dermal skin fibroblasts. Dietary CoQ10 supplementation is the only available treatment for these deficiencies that require a rapid and distinct diagnosis. Here we review methods for determining CoQ10 content by HPLC separation and identification using alternative approaches including electrochemical detection and mass spectrometry. Also, we review procedures to determine the CoQ10 biosynthesis rate using labeled precursors.

  2. q-Gamow States for intermediate energies

    CERN Document Server

    Plastino, A; Zamora, D J

    2016-01-01

    In a recent paper [Nuc. Phys. A {\\bf 948}, (2016) 19] we have demonstrated the possible existence of Tsallis' q-Gamow states. Now, accelerators' experimental evidence for Tsallis' distributions has been ascertained only at very high energies. Here, instead, we develop a different set of q-Gamow states for which the associated q-Breit-Wigner distribution could easily be found at intermediate energies, for which accelerators are available at many locations. In this context, it should be strongly emphasized [Physica A {\\bf 388} (2009) 601] that, empirically, one never exactly and unambiguously "detects" pure Gaussians, but rather q-Gaussians. A prediction is made via Eq.(3.30)

  3. A rare case of trisomy 11q23.3-11q25 and trisomy 22q11.1-22q11.21.

    Science.gov (United States)

    Zou, P-S; Li, H-F; Chen, L-S; Ma, M; Chen, X-H; Xue, D; Cao, D-H

    2016-05-09

    Partial duplication of the long arm of chromosome 11 and the partial trisomy of 22q are uncommon karyotypic abnormalities. Here, we report the case of a 6-year-old girl who showed partial trisomy of 11q and 22q, as a result of a maternal balanced reciprocal translocation (11;22), and exhibited dysmorphic features, severe intellectual disability, brain malformations, and speech delay related to this unique chromosomal abnormality. Array comparative genomic hybridization (array CGH) revealed a gain in copy number on the long arm of chromosome 11, spanning at least 18.22 Mb. Additionally, there was a gain in copy number on the long arm of chromosome 22, spanning at least 3.46 Mb. FISH analysis using a chromosome 11 short arm telomere probe (11p14.2), a chromosome 11 long arm telomere probe (11q24.3), and a chromosome 22 long arm telomere probe (22q13.33) confirmed the origin of the marker chromosome. It has been confirmed by the State Key Laboratory of Medical Genetics of China that this is the first reported instance of the karyotype 47,XX, +der(22)t(11;22)(q23.3;q11.1)mat in the world. Our study reports an additional case that can be used to further characterize and delineate the clinical ramifications of partial trisomy of 11q and 22q.

  4. A comparative evaluation of coenzyme Q10-loaded liposomes and solid lipid nanoparticles as dermal antioxidant carriers

    Directory of Open Access Journals (Sweden)

    Gokce EH

    2012-09-01

    could be listed as Q10 ≥ SLN-Q10 > LIPO-Q10.Conclusion: The LIPO-Q10 system was able to enhance cell proliferation. On the contrary, SLN-Q10 did not show protective effects against ROS accumulation. As a conclusion, liposomes seem to have advantages over SLN in terms of effective delivery of Q10 to skin for antioxidant purposes.Keywords: solid lipid nanoparticles, liposomes, coenzyme Q10, antioxidant, cytotoxicity

  5. The C1q family of proteins: insights into the emerging non-traditional functions

    Directory of Open Access Journals (Sweden)

    Berhane eGhebrehiwet

    2012-04-01

    Full Text Available Research conducted over the past 20 years have helped us unravel not only the hidden structural and functional subtleties of human C1q, but also has catapulted the molecule from a mere recognition unit of the classical pathway to a well-recognized molecular sensor of damage modified self or non-self antigens. Thus, C1q is involved in a rapidly expanding list of pathological disorders—including autoimmunity, trophoblast migration, preeclampsia and cancer. The results of two recent reports are provided to underscore the critical role C1q plays in health and disease. First is the observation by Singh and colleagues showing that pregnant C1q-/- mice recapitulate the key features of human preeclampsia that correlate with increased fetal death. Treatment of the C1q-/- mice with pravastatin restored trophoblast invasiveness, placental blood flow, and angiogenic balance and, thus, prevented the onset of preeclampsia. Second is the report by Hong et al., which showed that C1q can induce apoptosis of prostate cancer cells by activating the tumor suppressor molecule WW-domain containing oxydoreductase (WWOX or WOX1 and destabilizing cell adhesion. Downregulation of C1q on the other hand enhanced prostate hyperplasia and cancer formation due to failure of WOX1 activation. Recent evidence also shows that C1q belongs to a family of structurally and functionally related TNFα-like family of proteins that may have arisen from a common ancestral gene. Therefore C1q not only shares the diverse functions with the TNF family of proteins, but also explains why C1q has retained some of its ancestral cytokine-like activities. This review is intended to highlight some of the structural and functional aspects of C1q by underscoring the growing list of its non-traditional functions.

  6. Generating q-Commutator Identities and the q-BCH Formula

    Directory of Open Access Journals (Sweden)

    Andrea Bonfiglioli

    2016-01-01

    Full Text Available Motivated by the physical applications of q-calculus and of q-deformations, the aim of this paper is twofold. Firstly, we prove the q-deformed analogue of the celebrated theorem by Baker, Campbell, and Hausdorff for the product of two exponentials. We deal with the q-exponential function expq⁡(x=∑n=0∞(xn/[n]q!, where [n]q=1+q+⋯+qn-1 denotes, as usual, the nth q-integer. We prove that if x and y are any noncommuting indeterminates, then expq⁡(xexpq⁡(y=expq⁡(x+y+∑n=2∞Qn(x,y, where Qn(x,y is a sum of iterated q-commutators of x and y (on the right and on the left, possibly, where the q-commutator [y,x]q≔yx-qxy has always the innermost position. When [y,x]q=0, this expansion is consistent with the known result by Schützenberger-Cigler: expq⁡(xexpq⁡(y=expq⁡(x+y. Our result improves and clarifies some existing results in the literature. Secondly, we provide an algorithmic procedure for obtaining identities between iterated q-commutators (of any length of x and y. These results can be used to obtain simplified presentation for the summands of the q-deformed Baker-Campbell-Hausdorff Formula.

  7. Nuclear problems in astrophysical q-plasmas and environments

    CERN Document Server

    Coraddu, M; Quarati, P; Scarfone, A M

    2009-01-01

    Experimental measurements in terrestrial laboratory, space and astrophysical observations of variation and fluctuation of nuclear decay constants, measurements of large enhancements in fusion reaction rate of deuterons implanted in metals and electron capture by nuclei in solar core indicate that these processes depend on the environment where take place and possibly also on the fluctuation of some extensive parameters and eventually on stellar energy production. Electron screening is the first important environment effect. We need to develop a treatment beyond the Debye-Huckel screening approach, commonly adopted within global thermodynamic equilibrium. Advances in the description of these processes can be obtained by means of q-thermostatistics and/or superstatistics for metastable states. This implies to handle without ambiguities the case q<1.

  8. Study of nonleptonic $B_{q}^{\\ast}$ ${\\to}$ $D_{q}V$ and $P_{q} D^*$ weak decays

    CERN Document Server

    Chang, Qin; Sun, Junfeng; Wang, Xiaolin; Yang, Yueling

    2016-01-01

    Motivated by the powerful capability of measurement for the $b$-flavored hadron rare decays at LHC and SuperKEKB/Belle-II, the nonleptonic $\\bar{B}^{\\ast}$ ${\\to}$ $D\\bar{D}^{\\ast}$, $D{\\rho^-}$, $DK^{\\ast-}$, ${\\pi}D^{\\ast}$ and $KD^{\\ast}$ weak decays are studied in detail. With the amplitudes calculated with factorization approach and the form factors of $B^{\\ast}$ transition into pseudoscalar meson evaluated with the BSW model, branching fractions and polarization fractions are firstly presented. Numerically, the CKM-favored $\\bar{B}_{q}^{\\ast}$ ${\\to}$ $D_{q}D_{s}^{{\\ast}-}$ and $D_{q}{\\rho}^{-}$ decays have large branching fractions, $\\sim$ $10^{-8}$, which should be sought for with priority and firstly observed by LHC and Belle-II experiments. The $\\bar{B}^{\\ast}_q$ ${\\to}$ $D_qK^{\\ast}$ and $D_q{\\rho}$ decays are dominated by the longitudinal polarization states. While, the parallel polarization fractions of $\\bar{B}^{\\ast}_q$ ${\\to}$ $D_q\\bar{D}^{\\ast}$ decays are comparable with the longitudinal one...

  9. PARTIAL 3Q DUPLICATION SYNDROME AND ASSIGNMENT OF D3S5 TO 3Q25-3Q28

    NARCIS (Netherlands)

    VANESSEN, AJ; KOK, K; van den Berg, Anke; DEJONG, B; STELLINK, F; BOS, AF; SCHEFFER, H; BUYS, CHCM

    1991-01-01

    We report a girl with a de novo duplication of the distal part of the long arm of chromosome 3 and review the literature. Our patient had the facial characteristics and many other anomalies of the partial 3q duplication syndrome. As a hitherto undescribed symptom in partial 3q trisomy syndrome, she

  10. Syntenic homology of human unique DNA sequences within chromossome regions 5q31, 10q22, 13q32-33 and 19q13.1 in the great apes

    Directory of Open Access Journals (Sweden)

    Vallente-Samonte Rhea U.

    2000-01-01

    Full Text Available Homologies between chromosome banding patterns and DNA sequences in the great apes and humans suggest an apparent common origin for these two lineages. The availability of DNA probes for specific regions of human chromosomes (5q31, 10q22, 13q32-33 and 19q13.1 led us to cross-hybridize these to chimpanzee (Pan troglodytes, PTR, gorilla (Gorilla gorilla, GGO and orangutan (Pongo pygmaeus, PPY chromosomes in a search for equivalent regions in the great apes. Positive hybridization signals to the chromosome 5q31-specific DNA probe were observed at HSA 5q31, PTR 4q31, GGO 4q31 and PPY 4q31, while fluorescent signals using the chromosome 10q22-specific DNA probe were noted at HSA 10q22, PTR 8q22, GGO 8q22 and PPY 7q22. The chromosome arms showing hybridization signals to the Quint-EssentialTM 13-specific DNA probe were identified as HSA 13q32-33, PTR 14q32-33, GGO 14q32-33 and PPY 14q32-33, while those presenting hybridization signals to the chromosome 19q13.1-specific DNA probe were identified as HSA 19q13.1, PTR 20q13, GGO 20q13 and PPY 20q13. All four probes presumably hybridized to homologous chromosomal locations in the apes, which suggests a homology of certain unique DNA sequences among hominoid species.

  11. Q-bosonization of the quantum group GL$_{q}$(2) based on the Gauss decomposition

    CERN Document Server

    Damaskinsky, E V; Damaskinsky, E V; Sokolov, M A

    1995-01-01

    The new method of q-bosonization for quantum groups based on the Gauss decomposition of a transfer matrix of generators is suggested. The simplest example of the quantum group GL_q(2) is considered in some details.

  12. Triply heavy tetraquark states with the $QQ\\bar{Q}\\bar{q}$ configuration

    CERN Document Server

    Chen, Kan; Wu, Jing; Liu, Yan-Rui; Zhu, Shi-Lin

    2016-01-01

    In the framework of the color-magnetic interaction, we systematically investigate the mass splittings of the $QQ\\bar{Q}\\bar{q}$ tetraquark states and estimated their rough masses in this work. These systems include the explicitly exotic states $cc\\bar{b}\\bar{q}$ and $bb\\bar{c}\\bar{q}$ and the hidden exotic states $cc\\bar{c}\\bar{q}$, $cb\\bar{b}\\bar{q}$, $bc\\bar{c}\\bar{q}$, and $bb\\bar{b}\\bar{q}$. If a state around the estimated mass region could be observed, its nature as a genuine tetraquark is favored. The strong decay patterns shown here will be helpful to the experimental search for these exotic states.

  13. Estimating Earth's modal Q with epicentral stacking method

    Science.gov (United States)

    Chen, X.; Park, J. J.

    2014-12-01

    The attenuation rates of Earth's normal modes are the most important constraints on the anelastic state of Earth's deep interior. Yet current measurements of Earth's attenuation rates suffer from 3 sources of biases: the mode coupling effect, the beating effect, and the background noise, which together lead to significant uncertainties in the attenuation rates. In this research, we present a new technique to estimate the attenuation rates of Earth's normal modes - the epicentral stacking method. Rather than using the conventional geographical coordinate system, we instead deal with Earth's normal modes in the epicentral coordinate system, in which only 5 singlets rather than 2l+1 are excited. By stacking records from the same events at a series of time lags, we are able to recover the time-varying amplitudes of the 5 excited singlets, and thus measure their attenuation rates. The advantage of our method is that it enhances the SNR through stacking and minimizes the background noise effect, yet it avoids the beating effect problem commonly associated with the conventional multiplet stacking method by singling out the singlets. The attenuation rates measured from our epicentral stacking method seem to be reliable measurements in that: a) the measured attenuation rates are generally consistent among the 10 large events we used, except for a few events with unexplained larger attenuation rates; b) the line for the log of singlet amplitudes and time lag is very close to a straight line, suggesting an accurate estimation of attenuation rate. The Q measurements from our method are consistently lower than previous modal Q measurements, but closer to the PREM model. For example, for mode 0S25 whose Coriolis force coupling is negligible, our measured Q is between 190 to 210 depending on the event, while the PREM modal Q of 0S25 is 205, and previous modal Q measurements are as high as 242. The difference between our results and previous measurements might be due to the lower

  14. Q in Other Solar Systems

    CERN Document Server

    Socrates, Aristotle; Dong, Subo

    2012-01-01

    A significant fraction of the hot Jupiters with final circularized orbital periods of less than 5 days are thought to form through the channel of high-eccentricity migration. Tidal dissipation at successive periastron passages removes orbital energy of the planet, which has the potential for changes in semi-major axis of a factor of ten to a thousand. In the equilibrium tide approximation we show that, in order for high-eccentricity migration to take place, the relative level of tidal dissipation in Jupiter analogues must be at least 10 times higher than the upper-limit attributed to the Jupiter-Io interaction. While this is not a severe problem for high-e migration, it contradicts the results of several previous calculations. We show that these calculations of high-e migration inadvertently over-estimated the strength of tidal dissipation by three to four orders of magnitude. These discrepancies were obscured by the use of various parameters, such as lag time \\tau, tidal quality factor Q and viscous time t_V...

  15. On Kantorovich modification of ( p , q $( p,q $ -Baskakov operators

    Directory of Open Access Journals (Sweden)

    Tuncer Acar

    2016-03-01

    Full Text Available Abstract The concern of this paper is to introduce a Kantorovich modification of ( p , q $( p,q $ -Baskakov operators and investigate their approximation behaviors. We first define a new ( p , q $( p,q $ -integral and construct the operators. The rate of convergence in terms of modulus of continuities, quantitative and qualitative results in weighted spaces, and finally pointwise convergence of the operators for the functions belonging to the Lipschitz class are discussed.

  16. Best polynomial degree reduction on q-lattices with applications to q-orthogonal polynomials

    KAUST Repository

    Ait-Haddou, Rachid

    2015-06-07

    We show that a weighted least squares approximation of q-Bézier coefficients provides the best polynomial degree reduction in the q-L2-norm. We also provide a finite analogue of this result with respect to finite q-lattices and we present applications of these results to q-orthogonal polynomials. © 2015 Elsevier Inc. All rights reserved.

  17. Some approximation properties of ( p , q $(p,q$ -Bernstein operators

    Directory of Open Access Journals (Sweden)

    Shin Min Kang

    2016-06-01

    Full Text Available Abstract This paper is concerned with the ( p , q $(p,q$ -analog of Bernstein operators. It is proved that, when the function is convex, the ( p , q $(p,q$ -Bernstein operators are monotonic decreasing, as in the classical case. Also, some numerical examples based on Maple algorithms that verify these properties are considered. A global approximation theorem by means of the Ditzian-Totik modulus of smoothness and a Voronovskaja type theorem are proved.

  18. Chronic Q fever in The Netherlands

    NARCIS (Netherlands)

    Kampschreur, L.M.

    2013-01-01

    From 2007-2010, during the recent Q fever epidemic in the Netherlands, over 4000 cases of acute Q fever were registered, which is an underestimation of the total amount of Coxiella burnetii infections due to a high amount of asymptomatic primary infections. In the literature it is stated that 1-5% o

  19. Instability of q-expectation value

    OpenAIRE

    Abe, Sumiyoshi

    2008-01-01

    q-Expectation value of a physical quantity is widely used in nonextensive statistical mechanics. Here, it is shown that the q-expectation value is not stable under small deformations of a probability distribution function, in general, whereas the ordinary expectation value is always stable.

  20. Stability properties of Q-stars

    Energy Technology Data Exchange (ETDEWEB)

    Becerril, R. [Instituto de Fisica y Matematicas, Universidad Michoacana de San Nicolas de Hidalgo. Edificio C-3, Cd. Universitaria, C.P. 58040 Morelia, Michoacan (Mexico); Bernal, A. [Departamento de Fisica, Centro de Investigacion y de Estudios Avanzados del IPN, AP 14-740, 07000 Mexico D.F. (Mexico); Guzman, F.S. [Instituto de Fisica y Matematicas, Universidad Michoacana de San Nicolas de Hidalgo. Edificio C-3, Cd. Universitaria, C.P. 58040 Morelia, Michoacan (Mexico)], E-mail: guzman@ifm.umich.mx; Nucamendi, U. [Instituto de Fisica y Matematicas, Universidad Michoacana de San Nicolas de Hidalgo. Edificio C-3, Cd. Universitaria, C.P. 58040 Morelia, Michoacan (Mexico)

    2007-12-06

    We present the evolution of Q-star configurations using numerical methods. We solve the full Einstein-Klein-Gordon system of equations and show that: Q-stars can be stable and unstable. The unstable branch is two fold: configurations with negative binding energy that collapse and form black holes, and others with positive binding energy that explode and release the scalar field.

  1. Understanding Insight in the Context of Q

    Science.gov (United States)

    Coghlan, David

    2012-01-01

    In Revans' learning formula, L = P + Q, Q represents "questioning insight", by which Revans means that insight comes out of the process of questioning programmed knowledge (P) in the light of experience. We typically focus on the content of an insight rather than on the act of insight. Drawing primarily on the work of Bernard Lonergan this paper…

  2. QTL Information Table: 826 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qLTG3-1, Resistance or Tolerance Other stress resistance low-temperature germinability... trait locus, qLTG3-1, controlling low-temperature germinability in rice. Proc Natl Acad Sci U S A 105, 12623-12628. ...

  3. Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants

    DEFF Research Database (Denmark)

    van der Valk, Ralf J P; Duijts, Liesbeth; Timpson, Nicolas J

    2014-01-01

    12, and rs8069176 near gasdermin B (GSDMB; P = 1.88 × 10(-8)) at 17q12-q21. We found a cis expression quantitative trait locus for the transcript soluble galactoside-binding lectin 9 (LGALS9) that is in linkage disequilibrium with rs944722. rs8069176 was associated with GSDMB and ORM1-like 3 (ORMDL3...

  4. Coenzyme Q10 effects in neurodegenerative disease

    Directory of Open Access Journals (Sweden)

    Meredith Spindler

    2009-11-01

    Full Text Available Meredith Spindler1, M Flint Beal1,2, Claire Henchcliffe1,21Department of Neurology, 2Department of Neuroscience, Weill Medical College of Cornell University, New York, NY, USAAbstract: Coenzyme Q10 (CoQ10 is an essential cofactor in the mitochondrial respiratory chain, and as a dietary supplement it has recently gained attention for its potential role in the treatment of neurodegenerative disease. Evidence for mitochondrial dysfunction in neurodegenerative disorders derives from animal models, studies of mitochondria from patients, identification of genetic defects in patients with neurodegenerative disease, and measurements of markers of oxidative stress. Studies of in vitro models of neuronal toxicity and animal models of neurodegenerative disorders have demonstrated potential neuroprotective effects of CoQ10. With this data in mind, several clinical trials of CoQ10 have been performed in Parkinson’s disease and atypical Parkinson’s syndromes, Huntington’s disease, Alzheimer disease, Friedreich’s ataxia, and amyotrophic lateral sclerosis, with equivocal findings. CoQ10 is widely available in multiple formulations and is very well tolerated with minimal adverse effects, making it an attractive potential therapy. Phase III trials of high-dose CoQ10 in large sample sizes are needed to further ascertain the effects of CoQ10 in neurodegenerative diseases.Keywords: coenzyme Q10, neurodegenerative disease, Parkinson’s disease, Huntington’s disease, mitochondrial dysfunction

  5. The $q$-deformed Bogoliubov transformations

    CERN Document Server

    Arraut, Ivan

    2016-01-01

    An algebraic generalization of the Bogoliubov transformation is introduced in the context of $q$-commutativity. The set of coefficients are promoted to operators where we work with a $q$-deformed action over the Bosonic algebra together with some generalized trigonometric hyperbolic identities. We make the analogous extension for the fermionic algebra.

  6. Chronic Q fever in The Netherlands

    NARCIS (Netherlands)

    Kampschreur, L.M.

    2013-01-01

    From 2007-2010, during the recent Q fever epidemic in the Netherlands, over 4000 cases of acute Q fever were registered, which is an underestimation of the total amount of Coxiella burnetii infections due to a high amount of asymptomatic primary infections. In the literature it is stated that 1-5%

  7. Stability properties of Q-stars

    Science.gov (United States)

    Becerril, R.; Bernal, A.; Guzmán, F. S.; Nucamendi, U.

    2007-12-01

    We present the evolution of Q-star configurations using numerical methods. We solve the full Einstein-Klein-Gordon system of equations and show that: Q-stars can be stable and unstable. The unstable branch is two fold: configurations with negative binding energy that collapse and form black holes, and others with positive binding energy that explode and release the scalar field.

  8. QTL Information Table: 502 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qSBR-3 Resistance or Tolerance Sheath blight resistance Sheath blight response RFLP C)Interval DHL ZYQ8 Ji...ngxi 17 G249 G164 pha Kunihiro, Y., Qian, Q., Sato, H., Teng, S., Zeng, D.L., Fujimot

  9. QTL Information Table: 324 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qSdn-5 Physiological trait Germination/dormancy germination percentage SSR d)Co-segregated BC1F1 N22 Nanji...ng 35 B RM480 rgn Tang, J.Y., Jiang, L., Hou, M.Y., Zhang, L.X., Zhai, H.Q., and Wan,

  10. QTL Information Table: 286 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qCC-1 Physiological trait Source activity Chlorophyll content Mixture C)Interval DHL ZYQ8 Ji...ngxi 17 B RG541 RG101 pha Teng, S., Qian, Q., Zeng, D., Kunihiro, Y., Fujimoto, K., Huang, D., and

  11. QTL Information Table: 367 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qGW-3 Morphological trait Seed Grain width RFLP C)Interval BIL Nipponbare Kasalath ...B G332 C80 pha Li, Z.F., Wan, J.M., Xia, J.F., and Zhai, H.Q. (2003). Mapping quantitative trait loci underl

  12. QTL Information Table: 366 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qGL-6 Morphological trait Seed Grain length RFLP C)Interval BIL Nipponbare Kasalath... B R674 R2549 pha Li, Z.F., Wan, J.M., Xia, J.F., and Zhai, H.Q. (2003). Mapping quantitative trait loci und

  13. The chromosome 9q subtelomere deletion syndrome

    NARCIS (Netherlands)

    Stewart, D.R.; Kleefstra, T.

    2007-01-01

    The chromosome 9q subtelomere deletion syndrome (9qSTDS) is among the first and most common clinically recognizable syndromes to arise from widespread testing by fluorescent in situ hybridization (FISH) of subtelomere deletions. There are about 50 reported cases worldwide. Affected individuals invar

  14. QTL Information Table: 482 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qRA5-1 Morphological trait Shoot/Seedling Root activity Mixture C)Interval RIL Zhenshan 97 Minghui 63 B C246 RM26 pha Cui, H., Peng, B., Xing, Z., Xu, G., Yu, B., and Zhang, Q. (2002). Molecular dissection of seedling-vigor and associated physiological traits in rice. Theor Appl Genet 105, 745-753. ...

  15. q-Besselian Frames in Banach Spaces

    Institute of Scientific and Technical Information of China (English)

    Yu Can ZHU

    2007-01-01

    In this paper, we introduce the concepts of q-Besselian frame and (p, σ)-near Riesz basis in a Banach space, where σ is a finite subset of positive integers and 1/p + 1/q=1 with p 1, q 1, and determine the relations among q-frame, p-Riesz basis, q-Besselian frame and (p, σ)-near Riesz basis in a Banach space. We also give some sufficient and necessary conditions on a q-Besselian frame for a Banach space. In particular, we prove reconstruction formulas for Banach1 spaces X and X* that if {Xn}∞n=1(∪)X is a q-Besselian frame for X, then there exists a p-Besselian frame {y*n}∞n=1(∪) X* for X* such that x = ∑∞n-1 y*n(x)xn for all x ∈ X, and x = ∑∞n-1 x*xny*n, for all x* ∈ X*. Lastly, we consider the stability of a q-Besselian frame for the Banach space X under perturbation. Some results of J. R. Holub, P. G. Casazza, O. Christensen and others in Hilbert spaces are extended to Banach spaces.

  16. Q-Technique and Graphics Research.

    Science.gov (United States)

    Kahle, Roger R.

    Because Q-technique is as appropriate for use with visual and design items as for use with words, it is not stymied by the topics one is likely to encounter in graphics research. In particular Q-technique is suitable for studying the so-called "congeniality" of typography, for various copytesting usages, and for multivariate graphics research. The…

  17. 3q27.3 microdeletional syndrome

    DEFF Research Database (Denmark)

    Thevenon, Julien; Callier, Patrick; Poquet, Hélène

    2014-01-01

    BACKGROUND: Since the advent of array-CGH, numerous new microdeletional syndromes have been delineated while others remain to be described. Although 3q29 subtelomeric deletion is a well-described syndrome, there is no report on 3q interstitial deletions. METHODS: We report for the first time seven...... (18.5report on a new microdeletional syndrome...

  18. Q-Technique and Graphics Research.

    Science.gov (United States)

    Kahle, Roger R.

    Because Q-technique is as appropriate for use with visual and design items as for use with words, it is not stymied by the topics one is likely to encounter in graphics research. In particular Q-technique is suitable for studying the so-called "congeniality" of typography, for various copytesting usages, and for multivariate graphics research. The…

  19. Genotype-phenotype correlation in 13q13.3-q21.3 deletion.

    Science.gov (United States)

    Tosca, Lucie; Brisset, Sophie; Petit, François M; Metay, Corinne; Latour, Stéphanie; Lautier, Benoît; Lebas, Axel; Druart, Luc; Picone, Olivier; Mas, Anne-Elisabeth; Prévot, Sophie; Tardieu, Marc; Goossens, Michel; Tachdjian, Gérard

    2011-01-01

    Pure interstitial deletions of the long arm of chromosome 13 are correlated with variable phenotypes according to the size and the location of the deleted region. Deletions involving the 13q13q21 region are rare. In order to establish interstitial 13q genotype-phenotype correlation, we used high resolution 244K oligonucleotide array in addition to conventional karyotype and molecular (fluorescent in situ hybridization, microsatellite markers analysis) techniques in two independent probands carrying a deletion 13q13 to 13q21. First patient was a 3-year-old girl with mental retardation and dysmorphy carrying a 13q13.3q21.31 de novo deletion diagnosed post-natally. The second one was a fetus with de novo del(13)(q14q21.2) associated with first trimester increased nuchal translucency. We showed that specific dysmorphic features (macrocephaly, high forehead, hypertelorism, large nose, large and malformed ears and retrognathia) were correlated to the common 13q14q21 chromosomal segment. Physical examination revealed overgrowth with global measurement up to the 95th percentile in both probands. This is the second description of overgrowth in patients carrying a 13q deletion. Haploinsufficiency of common candidates genes such as CKAP2, SUGT1, LECT1, DCLK1 and SMAD9, involved in cell division and bone development, is a possible mechanism that could explain overgrowth in both patients. This study underlines also that cytogenetic analysis could be performed in patients with overgrowth.

  20. Some identities of the q-Laguerre polynomials on q-Umbral calculus

    Science.gov (United States)

    Dere, Rahime

    2017-07-01

    Some interesting identities of Sheffer polynomials was given by Roman [11], [12]. In this paper, we study a q-analogue of Laguerre polynomials which are also q-Sheffer polynomials. Furthermore, we give some new properties and formulas of these q-Laguerre polynomials of higher order by using the theory of the umbral algebra and umbral calculus.

  1. Q and you: The application of Q methodology in recreation research

    Science.gov (United States)

    Whitney. Ward

    2010-01-01

    Researchers have used various qualitative and quantitative methods to deal with subjectivity in studying people's recreation experiences. Q methodology has been the most effective approach for analyzing both qualitative and quantitative aspects of experience, including attitudes or perceptions. The method is composed of two main components--Q sorting and Q factor...

  2. The geographical distribution of Q fever.

    Science.gov (United States)

    KAPLAN, M M; BERTAGNA, P

    1955-01-01

    The results of a WHO-assisted survey of the distribution of Q fever in 32 countries and an analysis of reports published to date indicate that Q fever exists in 51 countries on five continents. Q-fever infection was most often reported in man and the domestic ruminants, such as cattle, sheep, and goats.The disease was found to exist in most countries where investigations were carried out. Notable exceptions were Ireland, the Netherlands, New Zealand, Poland, and the Scandinavian countries. With the exception of Poland, where the results were inconclusive, all these countries import relatively few domestic ruminants-the most important animal reservoirs of human Q-fever infection. It seems, therefore, that the traffic of infected ruminants may be one of the most important, if not the most important, means for the geographical spread of Q fever. The importance, if any, of ticks associated with such traffic needs to be defined.

  3. Graded q-differential matrix algebra

    Science.gov (United States)

    Abramov, V.; Raknuzzaman, Md.

    2013-10-01

    We consider the algebra of square matrices of order N as graded q-differential algebra, where q is a primitive Nth root of unity. We study the differential calculus of this algebra determined by a differential d, which satisfies the graded q-Leibniz rule and dN = 0. A graded q-differential algebra can be viewed as a generalization of graded differential algebra, and we consider the higher degree elements of graded q-differential matrix algebra as analogs of differential forms. We use two matrices x,ξ, which generate the algebra of square matrices of order N in order to express these analogs of differential forms in terms of "coordinate" x and its differentials dx,d2x,...,dN-1x. We study an analog of connection and calculate its curvature.

  4. Q value analysis of microwave photonic filters

    Institute of Scientific and Technical Information of China (English)

    Lina ZHOU; Xinliang ZHANG; Enming XU

    2009-01-01

    This paper first presents the fundamental principles of the microwave photonic filters.As an example to explain how to implement a microwave photonic filter, a specific finite impulse response (FIR) filter is illustrated.Next, the Q value of the microwave photonic filters is analyzed theoretically, and methods around how to gain high Q value are discussed.Then,divided into FIR filter, first-order infinite impulse response (IIR) filter, and multi-order IIR filter, several novel microwave photonic filters with high Q value are listed and compared.The technical difficulties to get high Q value in first-order IIR filter and multi-order IIR filter are analyzed concretely.Finally, in order to gain higher Q value, a multi-order IIR microwave photonic filter that easily extends its order is presented and discussed.

  5. Q factors for antennas in dispersive media

    CERN Document Server

    Gustafsson, Mats; Cismasu, Marius

    2014-01-01

    Stored energy and Q-factors are used to quantify the performance of small antennas. Accurate and efficient evaluation of the stored energy is also essential for current optimization and the associated physical bounds. Here, it is shown that the frequency derivative of the input impedance and the stored energy can be determined from the frequency derivative of the electric field integral equation. The expressions for the differentiated input impedance and stored energies differ by the use of a transpose and Hermitian transpose in the quadratic forms. The quadratic forms also provide simple single frequency formulas for the corresponding Q-factors. The expressions are further generalized to antennas integrated in temporally dispersive media. Numerical examples that compare the different Q-factors are presented for dipole and loop antennas in conductive, Debye, Lorentz, and Drude media. The computed Q-factors are also verified with the Q-factor obtained from the stored energy in Brune synthesized circuit models.

  6. Coenzyme Q10 and male infertility.

    Science.gov (United States)

    Balercia, G; Mancini, A; Paggi, F; Tiano, L; Pontecorvi, A; Boscaro, M; Lenzi, A; Littarru, G P

    2009-07-01

    We had previously demonstrated that Coenzyme Q10 [(CoQ10) also commonly called ubiquinone] is present in well-measurable levels in human seminal fluid, where it probably exerts important metabolic and antioxidant functions; seminal CoQ10 concentrations show a direct correlation with seminal parameters (count and motility). Alterations of CoQ10 content were also shown in conditions associated with male infertility, such as asthenozoospermia and varicocele (VAR). The physiological role of this molecule was further clarified by inquiring into its variations in concentrations induced by different medical or surgical procedures used in male infertility treatment. We therefore evaluated CoQ10 concentration and distribution between seminal plasma and spermatozoa in VAR, before and after surgical treatment, and in infertile patients after recombinant human FSH therapy. The effect of CoQ10 on sperm motility and function had been addressed only through some in vitro experiments. In two distinct studies conducted by our group, 22 and 60 patients affected by idiopathic asthenozoospermia were enrolled, respectively. CoQ10 and its reduced form, ubiquinol, increased significantly both in seminal plasma and sperm cells after treatment, as well as spermatozoa motility. A weak linear dependence among the relative variations, at baseline and after treatment, of seminal plasma or intracellular CoQ10, ubiquinol levels and kinetic parameters was found in the treated group. Patients with lower baseline value of motility and CoQ10 levels had a statistically significant higher probability to be responders to the treatment. In conclusion, the exogenous administration of CoQ10 increases both ubiquinone and ubiquinol levels in semen and can be effective in improving sperm kinetic features in patients affected by idiopathic asthenozoospermia.

  7. Hierarchical regional cooperative Q-learning%分层的局部合作Q-学习

    Institute of Scientific and Technical Information of China (English)

    刘亮; 李龙澍

    2009-01-01

    多智能体Q-学习问题往往因为联合动作的个数指数级增长而变得无法解决.从研究分层强化学习入手,通过对强化学习中合作MAS的研究,在基于系统工作逻辑的研究基础上,提出了基于学习过程分层的局部合作强化学习,通过对独立Agent强化学习的知识考察,改进多Agent系统学习的效率,进一步提高了局部合作强化学习的效能.从而解决强化学习中的状态空间的维数灾难,并通过仿真足球的2vsl防守证明了算法的有效性.%Many multi-agent Q-learning problems can not be solved because of the number of joint actions is exponential in the number of agents.Based on the study of the cooperation in MAS in reinforcement learning and on the basis of the research in the system logic,this paper puts forward the hierarchical regional cooperation reinforcement learning based on learning process.By studying the knowledge of Agent reinforcement learning and improving the multi-Agent study efficiency,the performance of the regional cooperation reinforcement learning is further enhanced,combining with the mission action based on joint action and potential field model so as to solve the dimensional disaster in state space of reinforcement learning.This algorithm is used in a subtask of robot soccer and its effectiveness is validated by experiments.

  8. De novo interstitial deletion q16.2q21 on chromosome 6

    Energy Technology Data Exchange (ETDEWEB)

    Villa, A.; Urioste, M.; Luisa, M. [Universidad Complutense, Madrid (Spain)] [and others

    1995-01-30

    A de novo interstitial deletion of 6q16.2q21 was observed in a 23-month-old boy with mental and psychomotor delay, obese appearance, minor craniofacial anomalies, and brain anomalies. We compare clinical manifestations of this patient with those observed in previously reported cases with similar 6q interstitial deletions. It is interesting to note the clinical similarities between some patients with interstitial deletions of 6q16 or q21 bands and patients with Prader-Willi syndrome (PWS) and it may help to keep in mind cytogenetic studies of patients with some PWS findings. 24 refs., 3 figs., 2 tabs.

  9. Elliptic Quantum Groups U_{q,p}(gl_N) and E_{q,p}(gl_N)

    CERN Document Server

    Konno, Hitoshi

    2016-01-01

    We reformurate a central extension of Felder's elliptic quantum group in the FRST formulation as a topological algebra E_{q,p}(gl_N) over the ring of formal power series in p. We then discuss the isomorphism between E_{q,p}(gl_N) and the elliptic algebra U_{q,p}(gl_N) of the Drinfeld realization. An evaluation H-algebra homomorphism from U_{q,p}(gl_N) to a dynamical extension of the quantum affine algebra U_q(gl_N) resolves the problem into the one discussed by Ding and Frenkel in the trigonometric case. We also provide some useful formulas for the elliptic quantum determinants.

  10. Monads on Q-Cat and their lax extensions to Q-Dist

    OpenAIRE

    Lai, Hongliang; Tholen, Walter

    2016-01-01

    For a small quantaloid $\\mathcal{Q}$, we consider 2-monads on the 2-category $\\mathcal{Q}$-$\\bf{Cat}$ and their lax extensions to the 2-category $\\mathcal{Q}$-$\\bf{Dist}$ of small $\\mathcal{Q}$-categories and their distributors, in particular those lax extensions that are flat, in the sense that they map identity distributors to identity distributors. In fact, unlike in the discrete case, a 2-monad on $\\mathcal{Q}$-$\\bf{Cat}$ may admit only one flat lax extension. Every ordinary monad on the ...

  11. Local-area-enhanced, 2.5-meter resolution natural-color and color-infrared satellite-image mosaics of the Takhar mineral district in Afghanistan: Chapter Q in Local-area-enhanced, high-resolution natural-color and color-infrared satellite-image mosaics of mineral districts in Afghanistan

    Science.gov (United States)

    Davis, Philip A.; Cagney, Laura E.

    2013-01-01

    The U.S. Geological Survey (USGS), in cooperation with the U.S. Department of Defense Task Force for Business and Stability Operations, prepared databases for mineral-resource target areas in Afghanistan. The purpose of the databases is to (1) provide useful data to ground-survey crews for use in performing detailed assessments of the areas and (2) provide useful information to private investors who are considering investment in a particular area for development of its natural resources. The set of satellite-image mosaics provided in this Data Series (DS) is one such database. Although airborne digital color-infrared imagery was acquired for parts of Afghanistan in 2006, the image data have radiometric variations that preclude their use in creating a consistent image mosaic for geologic analysis. Consequently, image mosaics were created using ALOS (Advanced Land Observation Satellite; renamed Daichi) satellite images, whose radiometry has been well determined (Saunier, 2007a,b). This part of the DS consists of the locally enhanced ALOS image mosaics for the Takhar mineral district, which has industrial evaporite deposits. ALOS was launched on January 24, 2006, and provides multispectral images from the AVNIR (Advanced Visible and Near-Infrared Radiometer) sensor in blue (420–500 nanometer, nm), green (520–600 nm), red (610–690 nm), and near-infrared (760–890 nm) wavelength bands with an 8-bit dynamic range and a 10-meter (m) ground resolution. The satellite also provides a panchromatic band image from the PRISM (Panchromatic Remote-sensing Instrument for Stereo Mapping) sensor (520–770 nm) with the same dynamic range but a 2.5-m ground resolution. The image products in this DS incorporate copyrighted data provided by the Japan Aerospace Exploration Agency (©JAXA, 2008), but the image processing has altered the original pixel structure and all image values of the JAXA ALOS data, such that original image values cannot be recreated from this DS. As such

  12. Coenzyme Q10 suppresses Th17 cells and osteoclast differentiation and ameliorates experimental autoimmune arthritis mice.

    Science.gov (United States)

    Jhun, JooYeon; Lee, Seung Hoon; Byun, Jae-Kyeong; Jeong, Jeong-Hee; Kim, Eun-Kyung; Lee, Jennifer; Jung, Young-Ok; Shin, Dongyun; Park, Sung Hwan; Cho, Mi-La

    2015-08-01

    Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant synthesized in human body. This enzyme promotes immune system function and can be used as a dietary supplement. Rheumatoid arthritis (RA) is an autoimmune disease leading to chronic joint inflammation. RA results in severe destruction of cartilage and disability. This study aimed to investigate the effect of CoQ10 on inflammation and Th17 cell proliferation on an experimental rheumatoid arthritis (RA) mice model. CoQ10 or cotton seed oil as control was orally administrated once a day for seven weeks to mice with zymosan-induced arthritis (ZIA). Histological analysis of the joints was conducted using immunohistochemistry. Germinal center (GC) B cells, Th17 cells and Treg cells of the spleen tissue were examined by confocal microscopy staining. mRNA expression was measured by real-time PCR and protein levels were estimated by enzyme-linked immunosorbent assay (ELISA). Flow cytometric analysis (FACS) was used to evaluate Th17 cells and Treg cells. CoQ10 mitigated the severity of ZIA and decreased serum immunoglobulin concentrations. CoQ10 also reduced RANKL-induced osteoclastogenesis, inflammatory mediators and oxidant factors. Th17/Treg axis was reciprocally controlled by CoQ10 treatment. Moreover, CoQ10 treatment on normal mouse and human cells cultured in Th17 conditions decreased the number of Th17 cells and enhanced the number of Treg cells. CoQ10 alleviates arthritis in mice with ZIA declining inflammation, Th17 cells and osteoclast differentiation. These findings suggest that CoQ10 can be a potential therapeutic substance for RA.

  13. Complement C1q expression induced by Abeta in rat hippocampal organotypic slice cultures.

    Science.gov (United States)

    Fan, Rong; Tenner, Andrea J

    2004-02-01

    Amyloid beta peptide (Abeta) is a major component of senile plaques, one of the principle pathological features in Alzheimer's disease (AD) brains. Fibrillar Abeta has been shown to bind C1 via C1q, the recognition component of the classical complement pathway, resulting in the activation of the complement pathway, thereby initiating an inflammatory cascade in the brain. C1q has also been shown to enhance phagocytic activities of microglia, which could benefit in clearance of apoptotic cells or cellular debris. To begin to define the role of C1q in tissue injury mediated by Abeta, we assessed the appearance of C1q in hippocampal slice cultures treated with freshly solubilized or fibrillar Abeta 1-42. Here we demonstrate a dose- and time-dependent uptake of exogenously applied Abeta by pyramidal neurons in organotypic slice cultures from rat hippocampus. Importantly, when slices were immunostained with antibody against rat C1q, a distinct reactivity for C1q in cells within the neuronal cell layer of cornu ammonis (CA) of hippocampus, primarily the CA1/CA2, was observed in the Abeta-treated slices. No such immunoreactivity was detected in untreated cultures or upon addition of control peptides. ELISA assays also showed an increase in C1q in tissue extracts from slices of the treated group. Similarly, the mRNA level of C1q in slices was increased within 24 h after Abeta treatment. These data demonstrate that upon exposure to Abeta, C1q is expressed in neurons in this organotypic system. The induction of C1q may be an early, perhaps beneficial, tissue or cellular response to injury triggered by particular pathogenic stimuli.

  14. A case of de novo duplication of 15q24-q26.3

    Directory of Open Access Journals (Sweden)

    Hye Ran Kim

    2011-06-01

    Full Text Available Distal duplication, or trisomy 15q, is an extremely rare chromosomal disorder characterized by prenatal and postnatal overgrowth, mental retardation, and craniofacial malformations. Additional abnormalities typically include an unusually short neck, malformations of the fingers and toes, scoliosis and skeletal malformations, genital abnormalities, particularly in affected males, and, in some cases, cardiac defects. The range and severity of symptoms and physical findings may vary from case to case, depending upon the length and location of the duplicated portion of chromosome 15q. Most reported cases of duplication of the long arm of chromosome 15 frequently have more than one segmental imbalance resulting from unbalanced translocations involving chromosome 15 and deletions in another chromosome, as well as other structural chromosomal abnormalities. We report a female newborn with a de novo duplication, 15q24- q26.3, showing intrauterine overgrowth, a narrow asymmetric face with down-slanting palpebral fissures, a large, prominent nose, and micrognathia, arachnodactyly, camptodactyly, congenital heart disease, hydronephrosis, and hydroureter. Chromosomal analysis showed a 46,XX,inv(9(p12q13,dup(15(q24q26.3. Array comparative genomic hybridization analysis revealed a gain of 42 clones on 15q24-q26.3. This case represents the only reported patient with a de novo 15q24-q26.3 duplication that did not result from an unbalanced translocation and did not have a concomitant monosomic component in Korea.

  15. First order non-homogeneous q-difference equation for Stieltjes function characterizing q-orthogonal polynomials

    CERN Document Server

    Arvesú, J

    2012-01-01

    In this paper we give a characterization of some classical q-orthogonal polynomials in terms of a difference property of the associated Stieltjes function, i.e this function solves a first order non-homogeneous q-difference equation. The solutions of the aforementioned q-difference equation (given in terms of hypergeometric series) for some canonical cases, namely, q-Charlier, q-Kravchuk, q-Meixner and q-Hahn are worked out.

  16. On the Fock representation of the q-commutation relations

    CERN Document Server

    Dykema, K J; Dykema, Ken; Nica, Alexandru

    1993-01-01

    The q-commutation relations in the title are those that have recently received much attention, and that for -1<q<1 provide an interpolation between Bosonic and Fermionic statistics, passing through free statistics at q=0. We look at the C*-algebra R^q generated by the representation of these relations on the twisted Fock space of Bozejko-Speicher, and we find a canonical unitary U_q from the twisted Fock space to usual full Fock space, such that U_q R^q (U_q)^* contains the Cuntz algebra R^0, and such that we have equality for |q|<0.44.

  17. High Q-factor CMOS-MEMS inductor

    CERN Document Server

    Dai, Ching-Liang; Liu, Mao-Chen

    2008-01-01

    This study investigates a high Q-factor spiral inductor fabricated by the CMOS (complementary metal oxide semiconductor) process and a post-process. The spiral inductor is manufactured on silicon substrate using the 0.35 micrometers CMOS process. In order to reduce the substrate loss and enhance the Q-factor of the inductor, silicon substrate under the inductor is removed using a post-process. The post-process uses RIE (reactive ion etching) to etch the sacrificial layer of silicon dioxide, and then TMAH (tetra methyl ammonium hydroxide) is employed to remove the underlying silicon substrate and obtain the suspended spiral inductor. The advantage of the post process is compatible with the CMOS process. The Agilent 8510C network analyzer and a Cascade probe station are used to measure the performances of the spiral inductor. Experiments indicate that the spiral inductor has a Q-factor of 15 at 11 GHz, an inductance of 4 nH at 25.5 GHz and a self-resonance frequency of about 27 GHz.

  18. Combination of CO2 and Q-switched Nd:YAG lasers is more effective than Q-switched Nd:YAG laser alone for eyebrow tattoo removal.

    Science.gov (United States)

    Radmanesh, Mohammad; Rafiei, Zohreh

    2015-04-01

    The eyebrow tattoo removal using Q-switched lasers is usually prolonged. Other modalities may be required to enhance the efficacy and shorten the treatment course. To compare the efficacy of Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser alone versus combination of Q-switched Nd:YAG and Ultrapulse CO2 lasers for eyebrow tattoo removal after a single session. After local anesthesia, the right eyebrow of 20 patients was treated with Ultrapulse CO2 laser with the parameters of 4 J/cm(2) and 3.2 J/cm(2) for the first and the second passes. Both eyebrows were then treated with 1064-nm and 532-nm Q-switched Nd:YAG laser. The spot size and pulse duration were 3 mm and 5 nanoseconds for both wavelengths, and the fluence was 7 J/cm(2) for 1064 nm and 3 J/cm (2) for 532 nm. The side treated with combination of Q-switched Nd:YAG and CO2 lasers improved 75-100% in 6 of 20 patients versus only 1 of 20 in the side treated with Q-switched Nd:YAG alone. Similarly, the right side in 13 of 20 patients showed more than 50% improvement with combination therapy versus the left side (the monotherapy side), where only 6 of 20 cases showed more than 50% improvement. The Mann-Whitney test was 2.85 for the right side and 1.95 for the left side (P value = 0.007). Using Ultra pulse CO2 laser enhances the efficacy of Q-switched Nd:YAG laser in eyebrow tattoo removal.

  19. q-deformed Star Products and Moyal Brackets

    CERN Document Server

    Dayi, O F

    1996-01-01

    The standard and anti-standard ordered operators acting on two-dimensional q-deformed phase space are shown to satisfy algebras which can be called W_\\infty. q-star products and q-Moyal brackets corresponding to these algebras are constructed. Some applications like defining q-classical mechanics and q-path integrals are discussed.

  20. Using Q Methodology in Quality Improvement Projects.

    Science.gov (United States)

    Tiernon, Paige; Hensel, Desiree; Roy-Ehri, Leah

    Q methodology consists of a philosophical framework and procedures to identify subjective viewpoints that may not be well understood, but its use in nursing is still quite limited. We describe how Q methodology can be used in quality improvement projects to better understand local viewpoints that act as facilitators or barriers to the implementation of evidence-based practice. We describe the use of Q methodology to identify nurses' attitudes about the provision of skin-to-skin care after cesarean birth. Copyright © 2017 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses. Published by Elsevier Inc. All rights reserved.

  1. KFM 01A. Q-logging

    Energy Technology Data Exchange (ETDEWEB)

    Barton, Nick [Nick Barton and Associates (Norway)

    2003-03-01

    The first Forsmark potential repository site borehole KFM 01A provided core from 101.8 to 1000.7 m depth. This was independently Q-logged during a two-day period (19th-20th February, 2003), without access to BORMAP results or regional jointing frequencies or orientations. The Q-logging was intended to be an independent check for subsequent BORMAP-derived Q-parameter estimation. The Q-logging was accomplished using the manually-recorded 'histogram method' which allows the logger to enter Q-parameter ranges and depths directly into the appropriate histograms, which facilitates subsequent data processing using Excel spreadsheets. Successive pairs of core boxes, which contain an average of 11 meters of core in ten rows, were the source of ten opinions of each of the six Q-parameters, giving a total of 4920 recordings of Q-parameter values for the 164 core boxes. Data processing was divided into several parts, with successively increasing detail. The report therefore contains Q-histograms for the whole core, for four identified fracture(d) zones combined as if one unit, and then for the whole core minus these fracture(d) zones. This background rock mass quality is subsequently divided into nine depth zones or slices, and trends of variation with depth are tabulated. The four identified fracture(d) zones, which are actually of reasonable quality, are also analysed separately, and similarities and subtle differences are discerned between them. The overall quality of this first core is very good to excellent, with Q(mean) of 48.4, and a most frequent Q-value of 100. The range of quality is from 2.1 to 2130, which is the complete upper half of the six order of magnitude Q scale. Even the relatively fracture(d) zones, representing some 13% of the 900 m cored, have a combined Q(mean) of 13.9 and a range of quality of 2.1 to 150.

  2. Inflation Driven by q-de Sitter

    Science.gov (United States)

    Setare, M. R.; Momeni, D.; Kamali, V.; Myrzakulov, R.

    2016-02-01

    We propose a generalised de Sitter scale factor for the cosmology of early and late time universe, including single scalar field is called as inflaton. This form of scale factor has a free parameter q is called as nonextensivity parameter. When q = 1, the scale factor is de Sitter. This scale factor is an intermediate form between power-law and de Sitter. We study cosmology of such families. We show that both kinds of dark components, dark energy and dark matter simultaneously are described by this family of solutions. As a motivated idea, we investigate inflation in the framework of q-de Sitter. We consider three types of scenarios for inflation. In a single inflation scenario, we observe that, inflation ended without any specific ending inflation ϕ e n d , the spectral index and the associated running of the spectral index are n s - 1 ˜ -2 𝜖, α s ≡ 0. To end the inflation: we should have q={3}/{4}. We deduce that the inflation ends when the evolution of the scale factor is a( t) = e 3/4( t). With this scale factor there is no need to specify ϕ e n d . As an alternative to have inflation with ending point, We will study q-inflation model in the context of warm inflation. We propose two forms of damping term Γ. In the first case when Γ = Γ0, we show the scale invariant spectrum, (Harrison-Zeldovich spectrum, i.e. n s = 1) may be approximately presented by (q={9}/{10}, ~N=70). Also there is a range of values of R and n s which is compatible with the BICEP2 data where q={9}/{10}. In case Γ = Γ1 V( ϕ), it is observed that small values of a number of e-folds are assured for small values of q parameter. Also in this case, the scale-invariant spectrum may be represented by (q,N) = ({9}/{10},70). For q={9}/{10} a range of values of R and n s is compatible with the BICEP2 data. Consequently, the proposal of q-de Sitter is consistent with observational data. We observe that the non-extensivity parameter q plays a significant role in inflationary scenario.

  3. The q-Laguerre matrix polynomials.

    Science.gov (United States)

    Salem, Ahmed

    2016-01-01

    The Laguerre polynomials have been extended to Laguerre matrix polynomials by means of studying certain second-order matrix differential equation. In this paper, certain second-order matrix q-difference equation is investigated and solved. Its solution gives a generalized of the q-Laguerre polynomials in matrix variable. Four generating functions of this matrix polynomials are investigated. Two slightly different explicit forms are introduced. Three-term recurrence relation, Rodrigues-type formula and the q-orthogonality property are given.

  4. 奥迪Q7

    Institute of Scientific and Technical Information of China (English)

    雪凝

    2005-01-01

    近日,奥迪全面披露了奥迪Q7 SUV的技术数据。奥迪Q7 SUV是在2003年底特律车展上现身的派克峰概念车(Pikes Peak quattro)基础上开发的,Q7的问世标志着奥迪终于杀入了竞争激烈的SUV市场。

  5. Measurement of the Proton Structure Function $F_{2}$ at Very Low $Q^{2}$ at HERA

    CERN Document Server

    Breitweg, J; Derrick, Malcolm; Krakauer, D A; Magill, S; Musgrave, B; Pellegrino, A; Repond, J; Stanek, R; Yoshida, R; Mattingly, M C K; Abbiendi, G; Anselmo, F; Antonioli, P; Bari, G; Basile, M; Bellagamba, L; Boscherini, D; Bruni, A; Bruni, G; Cara Romeo, G; Castellini, G; Cifarelli, Luisa; Cindolo, F; Contin, A; Coppola, N; Corradi, M; De Pasquale, S; Giusti, P; Iacobucci, G; Laurenti, G; Levi, G; Margotti, A; Massam, Thomas; Nania, R; Palmonari, F; Pesci, A; Polini, A; Sartorelli, G; Zamora-Garcia, Yu E; Zichichi, A; Amelung, C; Bornheim, A; Brock, I; Coboken, K; Crittenden, James Arthur; Deffner, R; Hartmann, H; Heinloth, K; Hilger, E; Irrgang, P; Jakob, H P; Kappes, A; Katz, U F; Kerger, R; Paul, E; Schnurbusch, H; Stifutkin, A; Tandler, J; Voss, K C; Weber, A; Wieber, H; Bailey, D S; Barret, O; Brook, N H; Foster, B; Heath, G P; Heath, H F; McFall, J D; Piccioni, D; Rodrigues, E; Scott, J; Tapper, R J; Capua, M; Mastroberardino, A; Schioppa, M; Susinno, G; Jeoung, H Y; Kim, J Y; Lee, J H; Lim, I T; Ma, K J; Pac, M Y; Caldwell, A; Liu, W; Liu, X; Mellado, B; Paganis, S; Sampson, S; Schmidke, W B; Sciulli, F; Chwastowski, J; Eskreys, Andrzej; Figiel, J; Klimek, K H; Olkiewicz, K; Piotrzkowski, K; Przybycien, M B; Stopa, P; Zawiejski, L; Bednarek, B; Jelen, K; Kisielewska, D; Kowal, A M; Kowalski, T; Rulikowska-Zarebska, E; Suszycki, L; Szuba, D; Kotanski, Andrzej; Bauerdick, L A T; Behrens, U; Bienlein, J K; Burgard, C; Dannheim, D; Desler, K; Drews, G; Fox-Murphy, A; Fricke, U; Göbel, F; Göttlicher, P; Graciani, R; Haas, T; Hain, W; Hartner, G F; Hasell, D; Hebbel, K; Johnson, K F; Kasemann, M; Koch, W; Kötz, U; Kowalski, H; Lindemann, L; Löhr, B; Martínez, M; Milite, M; Monteiro, T; Moritz, M; Notz, D; Pelucchi, F; Petrucci, M C; Rohde, M; Saull, P R B; Savin, A A; Schneekloth, U; Selonke, F; Sievers, M; Stonjek, S; Tassi, E; Wolf, G; Wollmer, U; Youngman, C; Zeuner, W; Coldewey, C; López-Duran-Viani, A; Meyer, A; Schlenstedt, S; Straub, P B; Barbagli, G; Gallo, E; Pelfer, P G; Maccarrone, G D; Votano, L; Bamberger, Andreas; Benen, A; Eisenhardt, S; Markun, P; Raach, H; Wölfle, S; Bussey, Peter J; Bell, M; Doyle, A T; Lee, S W; Lupi, A; MacDonald, N; McCance, G J; Saxon, D H; Sinclair, L E; Skillicorn, Ian O; Waugh, R; Bohnet, I; Gendner, N; Holm, U; Meyer-Larsen, A; Salehi, H; Wick, K; Garfagnini, A; Gialas, I; Gladilin, L K; Kcira, D; Klanner, Robert; Lohrmann, E; Poelz, G; Zetsche, F; Goncalo, R; Long, K R; Miller, D B; Tapper, A D; Walker, R; Mallik, U; Cloth, P; Filges, D; Ishii, T; Kuze, M; Nagano, K; Tokushuku, K; Yamada, S; Yamazaki, Y; Ahn, S H; Lee, S B; Park, S K; Lim, H; Park, I H; Son, D; Barreiro, F; García, G; Glasman, C; González, O; Labarga, L; Del Peso, J; Redondo, I; Terron, J; Barbi, M S; Corriveau, F; Hanna, D S; Ochs, A; Padhi, S; Riveline, M; Stairs, D G; Wing, M; Tsurugai, T; Antonov, A; Bashkirov, V; Danilov, M V; Dolgoshein, B A; Gladkov, D; Sosnovtsev, V V; Suchkov, S; Dementev, R K; Ermolov, P F; Golubkov, Yu A; Katkov, I I; Khein, L A; Korotkova, N A; Korzhavina, I A; Kuzmin, V A; Lukina, O Yu; Proskuryakov, A S; Shcheglova, L M; Solomin, A N; Vlasov, N N; Zotkin, S A; Bokel, C; Botje, M; Brümmer, N; Engelen, J; Grijpink, S; Koffeman, E; Kooijman, P M; Schagen, S; Van Sighem, A; Tiecke, H G; Tuning, N; Velthuis, J J; Vossebeld, Joost Herman; Wiggers, L; De Wolf, E; Acosta, D; Bylsma, B; Durkin, L S; Gilmore, J; Ginsburg, C M; Kim, C L; Ling, T Y; Boogert, S; Cooper-Sarkar, A M; Devenish, R C E; Grosse-Knetter, J; Matsushita, T; Quadt, A; Ruske, O; Sutton, M R; Walczak, R; Bertolin, A; Brugnera, R; Carlin, R; Dal Corso, F; Dosselli, U; Dusini, S; Limentani, S; Morandin, M; Posocco, M; Stanco, L; Stroili, R; Turcato, M; Voci, C; Adamczyk, L; Iannotti, L; Oh, B Y; Okrasinski, J R; Toothacker, W S; Whitmore, J J; Iga, Y; D'Agostini, Giulio; Marini, G; Nigro, A; Cormack, C; Hart, J C; McCubbin, N A; Shah, T P; Epperson, D E; Heusch, C A; Sadrozinski, H F W; Seiden, A; Wichmann, R; Williams, D C; Pavel, N; Abramowicz, H; Dagan, S; Kananov, S; Kreisel, A; Levy, A; Abe, T; Fusayasu, T; Umemori, K; Yamashita, T; Hamatsu, R; Hirose, T; Inuzuka, M; Kitamura, S; Nishimura, T; Arneodo, M; Cartiglia, N; Cirio, R; Costa, M; Ferrero, M I; Maselli, S; Monaco, V; Peroni, C; Ruspa, M; Sacchi, R; Solano, A; Staiano, A; Dardo, M; Bailey, D C; Fagerstroem, C P; Galea, R; Koop, T; Levman, G M; Martin, J F; Orr, R S; Polenz, S; Sabetfakhri, A; Simmons, D; Butterworth, J M; Catterall, C D; Hayes, M E; Heaphy, E A; Jones, T W; Lane, J B; West, B J; Ciborowski, J; Ciesielski, R; Grzelak, G; Nowak, R J; Pawlak, J M; Pawlak, R; Smalska, B; Tymieniecka, T; Wróblewski, A K; Zakrzewski, J A; Zarnecki, A F; Adamus, M; Gadaj, T; Deppe, O; Eisenberg, Y; Hochman, D; Karshon, U; Badgett, W F; Chapin, D; Cross, R; Foudas, C; Mattingly, S E K; Reeder, D D; Smith, W H; Vaiciulis, A W; Wildschek, T; Wodarczyk, M; Deshpande, A A; Dhawan, S K; Hughes, V W; Bhadra, S; Cole, J E; Frisken, W R; Hall-Wilton, R; Khakzad, M; Menary, S R

    2000-01-01

    A measurement of the proton structure function F_2(x,Q^2) is presented in the kinematic range 0.045 GeV^2 < Q^2 < 0.65 GeV^2 and 6*10^{-7} < x < 1*10^{-3}. The results were obtained using a data sample corresponding to an integrated luminosity of 3.9pb^-1 in e^+p reactions recorded with the ZEUS detector at HERA. Information from a silicon-strip tracking detector, installed in front of the small electromagnetic calorimeter used to measure the energy of the final-state positron at small scattering angles, together with an enhanced simulation of the hadronic final state, has permitted the extension of the kinematic range beyond that of previous measurements. The uncertainties in F_2 are typically less than 4%. At the low Q^2 values of the present measurement, the rise of F_2 at low x is slower than observed in HERA data at higher Q^2 and can be described by Regge theory with a constant logarithmic slope. The dependence of F_2 on Q^2 is stronger than at higher Q^2 values, approaching, at the lowest Q...

  6. Characterization of a gC1qR from the giant freshwater prawn, Macrobrachium rosenbergii.

    Science.gov (United States)

    Ye, Ting; Huang, Xin; Wang, Xian-Wei; Shi, Yan-Ru; Hui, Kai-Min; Ren, Qian

    2015-03-01

    gC1qR, as a multicompartmental and a multifunctional protein, plays an important role in innate immunity. In this study, a gC1qR homolog (MrgC1qR) in the giant freshwater prawn, Macrobrachium rosenbergii was identified. MrgC1qR, a 258-amino-acid polypeptide, shares high identities with gC1qR from other species. MrgC1qR gene was expressed in different tissues and was highest expressed in the hepatopancreas. In addition, the MrgC1qR transcript was significantly enhanced after 6 h of white spot syndrome virus (WSSV) infection or post 2 h, 24 h of Vibrio anguillarum challenge compared to appropriate controls. Moreover, recombinant MrgC1qR (rMrgC1qR) had bacterial binding activity, the result also revealed that rMrgC1qR could bind pathogen-associated molecular patterns (PAMPs) such as LPS or PGN, suggesting that MrgC1qRmight function as a pathogen-recognition receptor (PRR). Furthermore, glutathione S-transferase (GST) pull-down assays showed that rMrgC1qR with GST-tag could bind to rMrFicolin1 or rMrFicolin2 with His-tag. Altogether, these results may demonstrate a role for MrgC1qR in innate immunity in the giant freshwater prawns.

  7. Misunderstandings about Q and 'Cochran's Q test' in meta-analysis.

    Science.gov (United States)

    Hoaglin, David C

    2016-02-20

    Many meta-analyses report using 'Cochran's Q test' to assess heterogeneity of effect-size estimates from the individual studies. Some authors cite work by W. G. Cochran, without realizing that Cochran deliberately did not use Q itself to test for heterogeneity. Further, when heterogeneity is absent, the actual null distribution of Q is not the chi-squared distribution assumed for 'Cochran's Q test'. This paper reviews work by Cochran related to Q. It then discusses derivations of the asymptotic approximation for the null distribution of Q, as well as work that has derived finite-sample moments and corresponding approximations for the cases of specific measures of effect size. Those results complicate implementation and interpretation of the popular heterogeneity index I(2) . Also, it turns out that the test-based confidence intervals used with I(2) are based on a fallacious approach. Software that outputs Q and I(2) should use the appropriate reference value of Q for the particular measure of effect size and the current meta-analysis. Q is a key element of the popular DerSimonian-Laird procedure for random-effects meta-analysis, but the assumptions of that procedure and related procedures do not reflect the actual behavior of Q and may introduce bias. The DerSimonian-Laird procedure should be regarded as unreliable.

  8. QTL Information Table: 28 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Morphological trait Dwarf plant height SSR d)Co-segregated BC3F2 Teqing common wild....Q. (2004). Identification of quantitative trait loci controlling plant height and days to heading from Yuan

  9. Genetics Home Reference: 5q minus syndrome

    Science.gov (United States)

    ... for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells. Blood. 2011 Mar ... U, List A, MacBeth KJ. Lenalidomide as a disease-modifying agent in patients with del(5q) myelodysplastic ...

  10. QTL Information Table: 659 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qRCT6b Resistance or Tolerance Cold tolerance cold tolerance at the reproductive st...K., Kato, A., Xu, F., Yu, T., and Zhang, D. (2004). Identification of Quantitative Trait Loci Controlling Cold Tolerance

  11. Cosmetics Safety Q&A: Shelf Life

    Science.gov (United States)

    ... Resources for You Consumers Cosmetics Safety Q&A: Shelf Life Share Tweet Linkedin Pin it More sharing ... Email Print FAQs Main Page What is the shelf life of cosmetics? The shelf life for eye- ...

  12. Q-thruster Breadboard Campaign Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Q-thruster technology is a mission enabling form of electric propulsion and is already being traded by NASA's Concept Architecture Team (CAT) & Human Space...

  13. QTL Information Table: 369 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qET-6 Physiological trait Eating quality Endosperm translucency RFLP C)Interval BIL...tative trait loci underlying appearance quality of rice grains (Oryza sativa L.). Yi Chuan Xue Bao 30, 251-259. ...

  14. QTL Information Table: 368 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qPGWC-6b Physiological trait Eating quality Percentages of grains with chalkiness R...3). Mapping quantitative trait loci underlying appearance quality of rice grains (Oryza sativa L.). Yi Chuan Xue Bao 30, 251-259. ...

  15. QTL Information Table: 521 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qVB-1 Morphological trait Culm/leaf no. of vascular bundles in peduncle RFLP C)Inte...2002). Molecular mapping of quantitative trait loci (QTL) for characters of vascular bundles in peduncle rel

  16. QTL Information Table: 997 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qPTD-2 Morphological trait Panicle/flower peduncle top diameter RFLP C)Interval DHL...02). QTL analysis of rice peduncle vascular bundle system and panicle traits. Acta Bot Sinica 44, 301-306 ...

  17. Computation of correlation matrices for tetraquark candidates with $J^P = 0^+$ and flavor structure $q_1 \\bar{q_2} q_3 \\bar{q}_3$

    CERN Document Server

    Berlin, Joshua; Alexandrou, Constantia; Brida, Mattia Dalla; Gravina, Mario; Wagner, Marc

    2015-01-01

    The conjecture that several recently observed mesons have a structure, which is not dominated by an ordinary quark-antiquark pair, but by a four-quark structure, is being actively investigated both theoretical and experimentally. Such a state may be characterized as a mesonic molecule or as a diquark-antidiquark pair. Lattice QCD provides a theoretically sound framework to study such states. To quantitatively investigate the internal structure of such mesons, one needs to precisely compute correlation matrices containing several interpolating operators including two and four quarks. Here we discuss certain technical aspects of such correlation matrices suited to study tetraquark candidates with $J^P = 0^+$ and flavor structure $q_1 \\bar{q_2} q_3 \\bar{q}_3$, e.g.\\ the $a_0(980)$ meson, the $D_{s0}^\\ast$ meson and some of the charged $c \\bar{c}$ $X$ states. Some numerical results for the $a_0(980)$ meson are presented.

  18. QTL Information Table: 272 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qFDN-3 Physiological trait Flowering Flowering duration RFLP C)Interval DHL IR64 Az... and Khush, G.S. (2002). Molecular mapping of quantitative trait loci for plant growth, yield and yield related trait

  19. QTL Information Table: 271 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qPHT-1 Morphological trait Dwarf Plant height RFLP C)Interval DHL IR64 Azucena B RZ..., G.S. (2002). Molecular mapping of quantitative trait loci for plant growth, yield and yield related traits

  20. QTL Information Table: 475 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qGR5-1 Physiological trait Germination/dormancy Germination rate Mixture C)Interval...). Molecular dissection of seedling-vigor and associated physiological traits in rice. Theor Appl Genet 105, 745-753. ...

  1. QTL Information Table: 325 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qPGWC8 Physiological trait Eating quality Percentage of chalkiness grains SSR B)Fin... pgwc8 gene affecting percentage of grains with chalkiness in rice (Oryza sativa. L). Rice Genetics Newsletter 21, 54-56. ...

  2. QTL Information Table: 278 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qHID-1 Morphological trait Seed Harvest index RFLP C)Interval DHL IR64 Azucena B RG..., G.S. (2002). Molecular mapping of quantitative trait loci for plant growth, yield and yield related traits

  3. QTL Information Table: 480 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qTAA3-1 Morphological trait Shoot/Seedling Total amylase activity Mixture C)Interva...). Molecular dissection of seedling-vigor and associated physiological traits in rice. Theor Appl Genet 105, 745-753. ...

  4. Environmental Chemistry Methods (ECM) Index - Q

    Science.gov (United States)

    Laboratories use testing methods to identify pesticides in water and soil. Environmental chemistry methods test soil and water samples to determine the fate of pesticides in the environment. Find methods for chemicals with Q as the first character.

  5. Skeletonized wave-equation inversion for Q

    KAUST Repository

    Dutta, Gaurav

    2016-09-06

    A wave-equation gradient optimization method is presented that inverts for the subsurface Q distribution by minimizing a skeletonized misfit function ε. Here, ε is the sum of the squared differences between the observed and the predicted peak/centroid frequency shifts of the early-arrivals. The gradient is computed by migrating the observed traces weighted by the frequency-shift residuals. The background Q model is perturbed until the predicted and the observed traces have the same peak frequencies or the same centroid frequencies. Numerical tests show that an improved accuracy of the inverted Q model by wave-equation Q tomography (WQ) leads to a noticeable improvement in the migration image quality.

  6. QTL Information Table: 967 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qREP-6 Resistance or Tolerance Other soil stress tolerance root elongation under phosphorus...omura, K., and Ikehashi, H. (2008). Genetic analysis of root elongation induced by phosphorus deficiency in

  7. R Measurements at High Q^2

    OpenAIRE

    Harris, F. A.

    2001-01-01

    Previous Measurements of R at high Q^2 are reviewed. Recent R measurement results, including those from the Beijing Spectrometer Experiment, are described. The present status of R measurements and future measurement possiblities are summarized.

  8. QTL Information Table: 755 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Physiological trait Eating quality Pasting time, time of initial viscosity increase...o, L.J., Xing, Y.Z., Xu, C.G., and Zhang, Q. (2007). Genetic basis of 17 traits and viscosity parameters cha

  9. q-Gamow states for intermediate energies

    Energy Technology Data Exchange (ETDEWEB)

    Plastino, A. [La Plata National University and Argentina' s National Research Council, (IFLP-CCT-CONICET)-C. C. 727, 1900 La Plata (Argentina); Rocca, M.C., E-mail: mariocarlosrocca@gmail.com [La Plata National University and Argentina' s National Research Council, (IFLP-CCT-CONICET)-C. C. 727, 1900 La Plata (Argentina); Ferri, G.L. [Fac. de C. Exactas, National University La Pampa, Peru y Uruguay, Santa Rosa, La Pampa (Argentina); Zamora, D.J. [La Plata National University and Argentina' s National Research Council, (IFLP-CCT-CONICET)-C. C. 727, 1900 La Plata (Argentina)

    2016-11-15

    In a recent paper Plastino and Rocca (2016) [18] we have demonstrated the possible existence of Tsallis' q-Gamow states. Now, accelerators' experimental evidence for Tsallis' distributions has been ascertained only at very high energies. Here, instead, we develop a different set of q-Gamow states for which the associated q-Breit–Wigner distribution could easily be found at intermediate energies, for which accelerators are available at many locations. In this context, it should be strongly emphasized Vignat and Plastino (2009) [2] that, empirically, one never exactly and unambiguously “detects” pure Gaussians, but rather q-Gaussians. A prediction is made via Eq. (3.4).

  10. Simplified boson realization of the $so_q(3)$ subalgebra of $u_q(3)$ and matrix elements of $so_q(3)$ quadrupole operators

    CERN Document Server

    Raychev, P P; Lo-Iudice, N; Roussev, R P; Terziev, P A

    1997-01-01

    A simplified boson realization of the $so_q(3)$ subalgebra of $u_q(3)$ is constructed. A simplified form of the corresponding $so_q(3)$ basis states is obtained. The reduced matrix elements of a special second-rank tensor operator (quadrupole operator) are calculated in the $so_q(3)$ basis.

  11. Chromosome 10q tetrasomy: First reported case

    Energy Technology Data Exchange (ETDEWEB)

    Blackston, R.D.; May, K.M.; Jones, F.D. [Emory Univ., Atlanta, GA (United States)] [and others

    1994-09-01

    While there are several reports of trisomy 10q (at least 35), we are not aware of previous cases of 10q tetrasomy. We present what we believe to be the initial report of such a case. R.J. is a 6 1/2 year old white male who presented with multiple dysmorphic features, marked articulation problems, hyperactivity, and developmental delays. He is the product of a term uncomplicated pregnancy. There was a normal spontaneous vaginal delivery with a birth weight of 6 lbs. 4oz. and length was 19 1/2 inch. Dysmorphic features include small size, an asymmetrically small head, low set ears with overfolded helixes, bilateral ptosis, downslanting eyes, right eye esotropia, prominent nose, asymmetric facies, high palate, mild pectus excavatum deformity of chest, and hyperextensible elbow joints. The patient is in special needs classes for mildly mentally handicapped students. Chromosome analysis at a resolution of 800 bands revealed a complex rearrangement of chromosomes 10 and 11. The segment 10q25.3 to q16.3 appears to be inverted and duplicated within the long arm of chromosome 10 at band q25.3 and the same segment of chromosome 10 is present on the terminal end of the short arm of chromosome 11. There is no visible loss of material from chromosome 11. Fluorescence in situ hybridization was performed with a chromosome 10 specific {open_quotes}paint{close_quotes} to confirm that all of the material on the abnormal 10 and the material on the terminal short arm of 11 was from chromosome 10. Thus, it appears that the segment 10q25.3 to q26.3 is present in four copies. Parental chromosome studies are normal. We compared findings which differ in that the case of 10q tetrasomy did not have prenatal growth deficiency, microphthalmia, cleft palate, digital anomalies, heart, or renal defects. Whereas most cases of 10q trisomy are said to have severe mental deficiency, our case of 10q tetrasomy was only mildly delayed. We report this first apparent cited case of 10q tetrasomy.

  12. QTL Information Table: 573 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available spf6 Physiological trait Sterility Spikelet fertility SSR C)Interval F1 02428/Nanji...ng12 Balilla RG213 RM557 pha Song, X., Qiu, S.Q., Xu, C.G., Li, X.H., and Zhang, Q. (2005). Genetic dissection of embryo sac fertilit...y, pollen fertility, and their contributions to spikelet fertility of intersubspecific hybrids in rice. Theor Appl Genet 110, 205-211. ...

  13. Q-balls with scalar charges

    CERN Document Server

    Rubakov, V

    2010-01-01

    We consider Friedberg-Lee-Sirlin Q-balls in a (3+1)-dimensional model with vanishing scalar potential of one of the fields. The Q-ball is stabilized by the gradient energy of this field and carries scalar charge, over and beyond the global charge. The latter property is inherent also in a model with the scalar potential that does not vanish in some finite field region near the origin.

  14. q-Deformed Relativistic Fermion Scattering

    Directory of Open Access Journals (Sweden)

    Hadi Sobhani

    2017-01-01

    Full Text Available In this article, after introducing a kind of q-deformation in quantum mechanics, first, q-deformed form of Dirac equation in relativistic quantum mechanics is derived. Then, three important scattering problems in physics are studied. All results have satisfied what we had expected before. Furthermore, effects of all parameters in the problems on the reflection and transmission coefficients are calculated and shown graphically.

  15. QTL Information Table: 479 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qMRL5-1 Morphological trait Shoot/Seedling Max. root length Mixture C)Interval RIL Zhenshan 97 Minghui 63 A RM26 C1447 pha Cui, H., Peng, B., Xing, Z., Xu, G., Yu, B., and Zhang, Q. (2002). Molecular dissection of seedling-vigor and associated physiological traits in rice. Theor Appl Genet 105, 745-753. ...

  16. Isochromosome 17q in Chronic Lymphocytic Leukemia

    Directory of Open Access Journals (Sweden)

    Eyad Alhourani

    2015-01-01

    Full Text Available In chronic lymphocytic leukemia (CLL, presence of acquired cytogenetic abnormalities may help to estimate prognosis. However, deletion of TP53 gene, which is associated with an aggressive course of the disease and poor prognosis along with a lack of response to treatment, is one of the alterations which may escape cytogenetic diagnoses in CLL. Thus, other techniques have emerged such as interphase fluorescence in situ hybridization (iFISH. Deletion of TP53 may but must not go together with the formation of an isochromosome i(17q; surprisingly this subgroup of patients was not in the focus of CLL studies yet. This study was about if presence of i(17q could be indicative for a new subgroup in CLL with more adverse prognosis. As a result, TP53 deletion was detected in 18 out of 150 (12% here studied CLL cases. Six of those cases (~33% had the TP53 deletion accompanied by an i(17q. Interestingly, the cases with i(17q showed a tendency towards more associated chromosomal aberrations. These findings may be the bases for follow-up studies in CLL patients with TP53 deletion with and without i(17q; it may be suggested that the i(17q presents an even more adverse prognostic marker than TP53 deletion alone.

  17. Síndrome 18 q -heredado

    Directory of Open Access Journals (Sweden)

    Manuela Herrera Martínez

    1997-08-01

    Full Text Available Se presenta el hallazgo de una monosomía 18q-heredada por translocación materna (3q, 18q, en un niño de 4 años de edad con las características clínicas típicas, que presenta retraso mental y patrón dismórfico facial. Se realizó la correlación fenotipo-cariotipo, y el árbol genealógico de la familia. Se comparan los hallazgos del paciente con otros informados en la literatura médica y se enfatiza en el interés genético del estudio clínico y citogenético de los padres.It is presented the finding of an 18q-monosomy inherited by maternal translocation (3q, 18q in a 4-year-old boy with the typical clinical characteristics, that is, mental retardation and facial dysmorphia pattern. The phenotype-karyotype correlation and the pedigree were made. The patient's findings are compared with others reported in the medical literature, and the genetical interest of the clinical and cytogenetic study of the parents is emphasized.

  18. Action of μq(g) on Its Positive Part μq+(g)

    Institute of Scientific and Technical Information of China (English)

    Zhi Hua WANG; Li Bin LI

    2011-01-01

    In this paper,two kinds of skew derivations of a type of Nichols algebras are introduced,and then the relationship between them is investigated.In particular they satisfy the quantum Serre-relations.Therefore,the algebra generated by these derivations and corresponding automorphisms is a homomorphic image of the Drinfeld-Jimbo quantum enveloping algebra μq(g),which proves the Nichols algebra becomes aμq(g)-module algebra.But the Nichols algebra considered here is exactly μq+(g),namely,the positive part of the Drinfeld-Jimbo quantum enveloping algebra μq(g),it turns out that μq+(g)is a μq(g)-module algebra.

  19. CONVERGENCE ARTE FOR INTERATES OF q-BERNSTEIN POLYNOMIALS

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Recently, q-Bernstein polynomials have been intensively investigated by a number of authors. Their results show that for q ≠ 1, q-Bernstein polynomials possess of many interesting properties. In this paper, the convergence rate for iterates of both q-Bernstein when n →∞ and convergence rate of Bn(f,q;x) when f ∈ Cn-1[0, 1], q →∞ are also presented.

  20. A gC1qR prevents white spot syndrome virus replication in the freshwater crayfish Pacifastacus leniusculus.

    Science.gov (United States)

    Watthanasurorot, Apiruck; Jiravanichpaisal, Pikul; Söderhäll, Irene; Söderhäll, Kenneth

    2010-10-01

    The gC1qR/p32 protein is a multiple receptor for several proteins and pathogens. We cloned a gC1qR homologue in a crustacean, Pacifastacus leniusculus, and analyzed the expression of P. leniusculus C1qR (PlgC1qR) in various tissues. The gC1qR/p32 transcript was significantly enhanced by white spot syndrome virus (WSSV) infection 6 h after viral infection both in vitro in a hematopoietic tissue cell culture (Hpt) and in vivo compared to appropriate controls. Moreover, PlgC1qR silencing in both the Hpt cell culture and live crayfish enhanced the WSSV replication. In addition, by making a recombinant PlgC1qR protein we could show that if this recombinant protein was injected in a crayfish, Pacifastacus leniusculus, followed by injection of WSSV, this significantly reduced viral replication in vivo. Furthermore, if the recombinant PlgC1qR was incubated with Hpt cells and then WSSV was added, this also reduced viral replication. These experiments clearly demonstrate that recombinant PlgC1qR reduce WSSV replication both in vivo and in vitro. The results from a far-Western overlay and glutathione S-transferase pull-down assays showed that PlgC1qR could bind to VP15, VP26, and VP28. Altogether, these results demonstrate a role for PlgC1qR in antiviral activity against WSSV.

  1. $q$-deformed Painleve tau function and q-deformed conformal blocks

    CERN Document Server

    Bershtein, M A

    2016-01-01

    We propose $q$-deformation of the Gamayun-Iorgov-Lisovyy formula for Painlev\\'e $\\tau$ function. Namely we propose formula for $\\tau$ function for $q$-difference Painlev\\'e equation corresponding to $A_7^{(1)}{}'$ surface (and $A_1^{(1)}$ symmetry) in Sakai classification. In this formula $\\tau$ function equals the series of $q$-Virasoro Whittaker conformal blocks (equivalently Nekrasov partition functions for pure $SU(2)$ 5d theory).

  2. High rates of de novo 15q11q13 inversions in human spermatozoa

    Directory of Open Access Journals (Sweden)

    Molina Òscar

    2012-02-01

    Full Text Available Abstract Low-Copy Repeats predispose the 15q11-q13 region to non-allelic homologous recombination. We have already demonstrated that a significant percentage of Prader-Willi syndrome (PWS fathers have an increased susceptibility to generate 15q11q13 deletions in spermatozoa, suggesting the participation of intrachromatid exchanges. This work has been focused on assessing the incidence of de novo 15q11q13 inversions in spermatozoa of control donors and PWS fathers in order to determine the basal rates of inversions and to confirm the intrachromatid mechanism as the main cause of 15q11q13 anomalies. Semen samples from 10 control donors and 16 PWS fathers were processed and analyzed by triple-color FISH. Three differentially labeled BAC-clones were used: one proximal and two distal of the 15q11-q13 region. Signal associations allowed the discrimination between normal and inverted haplotypes, which were confirmed by laser-scanning confocal microscopy. Two types of inversions were detected which correspond to the segments involved in Class I and II PWS deletions. No significant differences were observed in the mean frequencies of inversions between controls and PWS fathers (3.59% ± 0.46 and 9.51% ± 0.87 vs 3.06% ± 0.33 and 10.07% ± 0.74. Individual comparisons showed significant increases of inversions in four PWS fathers (P Results suggest that the incidence of heterozygous inversion carriers in the general population could reach significant values. This situation could have important implications, as they have been described as predisposing haplotypes for genomic disorders. As a whole, results confirm the high instability of the 15q11-q13 region, which is prone to different types of de novo reorganizations by intrachromatid NAHR.

  3. The distribution of zeros of general q-polynomials

    Science.gov (United States)

    Álvarez-Nodarse, R.; Buendía, E.; Dehesa, J. S.

    1997-10-01

    A general system of q-orthogonal polynomials is defined by means of its three-term recurrence relation. This system encompasses many of the known families of q-polynomials, among them the q-analogue of the classical orthogonal polynomials. The asymptotic density of zeros of the system is shown to be a simple and compact expression of the parameters which characterize the asymptotic behaviour of the coefficients of the recurrence relation. This result is applied to specific classes of polynomials known by the names q-Hahn, q-Kravchuk, q-Racah, q-Askey and Wilson, Al Salam - Carlitz and the celebrated little and big q-Jacobi.

  4. Exchange Relations for the q-Vertex Operators of $U_q(\\widehat{sl2})$

    CERN Document Server

    Awata, H

    1993-01-01

    We consider the q-deformed Knizhnik-Zamolodchikov equation for the two point function of q-deformed vertex operators of $U_q(sl_2^)$. We give explicitly the fundamental solutions, the connection matrices and the exchange relations for the q-vertex operators of spin 1/2 and $j \\in {1\\over 2}{\\bf Z}_{\\geq 0}$. Consequently, we confirm that the connection matrices are equivalent to the elliptic Boltzman weights of IRF type obtained by the fusion procedure from ABF models.

  5. Numerical and Experimental Study of the Q Factor of High-Q Micropillar Cavities

    DEFF Research Database (Denmark)

    Gregersen, Niels; Reitzenstein, S.; Kistner, C.;

    2010-01-01

    to the effective reflectivity of the fundamental mode arising from coupling to scattering channels involving higher-order cavity modes and propagating Bloch modes in the distributed Bragg reflectors (DBRs). We show how these weak contributions lead to strong variations of the Q factor, and we relate the average......Micropillar cavities are potential candidates for high-efficiency single-photon sources and are testbeds for cavity quantum electrodynamics experiments. In both applications a high quality (Q) factor is desired. It was recently shown that the Q of high-Q semiconductor micropillar cavities exhibit...

  6. Robertsonian (15q;15q) translocation in a child with Angelman syndrome: Evidence of uniparental disomy

    Energy Technology Data Exchange (ETDEWEB)

    Tonk, V.; Schultz, R.A.; Wilson, G.N.; Schultz, R.A. [Univ. of Texas Southwestern Medical Center, Dallas, TX (United States)] [and others

    1996-12-30

    A balanced Robertsonian translocation 45,XY,t(15q15q) was detected in a patient with mental retardation, microcephaly, and hypertonia. Deletion of the 15q11q13 region was unlikely based on fluorescence in situ hybridization studies that revealed hybridization of appropriate DNA probes to both arms of the Robertsonian chromosome. Inheritance of alleles from 13 highly polymorphic DNA markers on chromosome 15 showed paternal uniparental isodisomy. The clinical, cytogenetic, and molecular results are consistent with a diagnosis of Angelman syndrome. 8 refs., 3 figs.

  7. Partial trisomy 18 in a family with a translocation (18;21)(q21;q22).

    Science.gov (United States)

    Niazi, M; Coleman, D V; Saldaña-Garcia, P

    1978-01-01

    A family is described in which 2 sibs had similar congenital abnormalities. Chromosome investigation of the mother and another child disclosed they were carriers of a translocation t(18;21)(q21;q22). The karyotype of one of the abnormal infants was determined and was found to be consistent with partial trisomy 18,46,XY,-21,+der (21),t(18;21) ((18pter leads to 18q21::21q22 leads to 2 lqter)mat. Images PMID:641950

  8. 3q26.33-3q27.2 microdeletion: a new microdeletion syndrome?

    Science.gov (United States)

    Mandrile, Giorgia; Dubois, Anna; Hoffman, Jodi D; Uliana, Vera; Di Maria, Emilio; Malacarne, Michela; Coviello, Domenico; Faravelli, Francesca; Zwolinski, Simon; Hellens, Stephen; Wright, Michael; Forzano, Francesca

    2013-04-01

    We describe three unrelated patients of European descent carrying an overlapping 3q26.33-3q27.2 microdeletion who share common clinical features: neonatal hypotonia, severe feeding problems, specific facial features, abnormal dentition, recurrent upper airways infections, developmental delay and severe growth impairment. One of the patients carries a smaller deletion and presents a milder phenotype. We propose that 3q26.33-3q27.2 microdeletion may represent a novel condition caused by the haploinsufficiency of dosage sensitive genes, several of which are involved in brain development.

  9. A child with mosaicism for deletion (14(q11.2q13

    Directory of Open Access Journals (Sweden)

    Thilini H Gamage

    2012-01-01

    Full Text Available In this case report we describe a child with a de novo deletion in the (q11.2q13 region of chromosome 14. The child presented with dysmorphic features - anophthalmia, microcephaly, and growth retardation. Cytogenetic studies showed mosaicism. The karyotype was 46,XX,del(14(q11.2;q13 [16] /46,XX [9]. We compared the features observed in this child with that of others with the same deletion reported in scientific literature and found that this is the first report of a child mosaic for this deletion. It is also the first time it has been reported in association with anophthalmia.

  10. Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1.

    Science.gov (United States)

    Chan, Wing Man; Tsoi, Ho; Wu, Chi Chung; Wong, Chi Hang; Cheng, Tat Cheung; Li, Hoi Yeung; Lau, Kwok Fai; Shaw, Pang Chui; Perrimon, Norbert; Chan, Ho Yin Edwin

    2011-05-01

    Polyglutamine (polyQ) diseases are a group of late-onset, progressive neurodegenerative disorders caused by CAG trinucleotide repeat expansion in the coding region of disease genes. The cell nucleus is an important site of pathology in polyQ diseases, and transcriptional dysregulation is one of the pathologic hallmarks observed. In this study, we showed that exportin-1 (Xpo1) regulates the nucleocytoplasmic distribution of expanded polyQ protein. We found that expanded polyQ protein, but not its unexpanded form, possesses nuclear export activity and interacts with Xpo1. Genetic manipulation of Xpo1 expression levels in transgenic Drosophila models of polyQ disease confirmed the specific nuclear export role of Xpo1 on expanded polyQ protein. Upon Xpo1 knockdown, the expanded polyQ protein was retained in the nucleus. The nuclear disease protein enhanced polyQ toxicity by binding to heat shock protein (hsp) gene promoter and abolished hsp gene induction. Further, we uncovered a developmental decline of Xpo1 protein levels in vivo that contributes to the accumulation of expanded polyQ protein in the nucleus of symptomatic polyQ transgenic mice. Taken together, we first showed that Xpo1 is a nuclear export receptor for expanded polyQ domain, and our findings establish a direct link between protein nuclear export and the progressive nature of polyQ neurodegeneration.

  11. All-optical Photonic Oscillator with High-Q Whispering Gallery Mode Resonators

    Science.gov (United States)

    Savchenkov, Anatoliy A.; Matsko, Andrey B.; Strekalov, Dmitry; Mohageg, Makan; Iltchenko, Vladimir S.; Maleki, Lute

    2004-01-01

    We demonstrated low threshold optical photonic hyper-parametric oscillator in a high-Q 10(exp 10) CaF2 whispering gallery mode resonator which generates stable 8.5 GHz signal. The oscillations result from the resonantly enhanced four wave mixing occurring due to Kerr nonlinearity of the material.

  12. The Quantum Superalgebra {{osp}q(1|2)} and a q-Generalization of the Bannai-Ito Polynomials

    Science.gov (United States)

    Genest, Vincent X.; Vinet, Luc; Zhedanov, Alexei

    2016-06-01

    The Racah problem for the quantum superalgebra {{osp}q(1|2)} is considered. The intermediate Casimir operators are shown to realize a q-deformation of the Bannai-Ito algebra. The Racah coefficients of {{osp}_q(1|2)} are calculated explicitly in terms of basic orthogonal polynomials that q-generalize the Bannai-Ito polynomials. The relation between these q-deformed Bannai-Ito polynomials and the q-Racah/Askey-Wilson polynomials is discussed.

  13. (α,β)-fuzzy Subalgebras of Q-algebras

    Institute of Scientific and Technical Information of China (English)

    Arsham Borumand Saeid

    2008-01-01

    In this note by two relations belonging to (∈) and quasi-coincidence (q) between fuzzy points and fuzzy sets,the notion of (α,β)-fuzzy Q-algebras,the level Q-subalgebra is introduced where α,β are any two of {∈,q,∈∨q,∈∧q} with α≠∈∧q.Then we state and prove some theorems which determine the relationship between these notions and Q-subalgebras.The images and inverse images of (α,β)-fuzzy Q-subalgebras are defined,and how the homomorphic images and inverse images of (α,β)-fuzzy Q-subalgebra becomes (α,β)-fuzzy Q-algebras are studied.

  14. A Characterisation of Tangent Subplanes of PG(2,q^3)

    CERN Document Server

    Barwick, S G

    2012-01-01

    In: S.G. Barwick and W.A. Jackson. Sublines and subplanes of PG(2,q^3) in the Bruck--Bose representation in PG(6,q). Finite Fields Th. App. 18 (2012) 93--107., the authors determine the representation of order-q-subplanes and order-q-sublines of PG(2,q^3) in the Bruck-Bose representation in PG(6,q). In particular, they showed that an order-q-subplane of PG(2,q^3) corresponds to a certain ruled surface in PG(6,q). In this article we show that the converse holds, namely that any ruled surface satisfying the required properties corresponds to a tangent order-q-subplane of PG(2,q^3).

  15. Partial monosomy 8q and partial trisomy 9q due to the maternal translocation t(8;9(q24.3;q34.1): a case report.

    Science.gov (United States)

    Tos, T; Alp, M Y; Eker, H K; Cebi, A H; Ikbal, M

    2014-01-01

    Partial trisomy 9q34-qter and partial monosomy 8q24.3-qter are very rare chromosomal abnormalities. Characteristic features of partial trisomy 9q34-qter are hypotonia, developmental delay, mild intellectual disability, dolichocephaly, distinct facial phenotype, long and thin fingers, and cardiac anomalies. Unlike the partial trisomy 9q34-qter, partial monosomy 8q24.3-qter has no distinct phenotype. Here we report a four years old female patient with partial trisomy 9q34-qter and partial monosomy 8q24.3-qter due to the maternal translocation t(8;9)(q24.3;q34. I). She has developmental delay, brachycephaly, facial dysmorphism, hand and foot anomalies, bilateral hearing loss, cardiac defect and abnormal brain MRI findings. To the best of our knowledge, this is the first report of the combination of partial trisomy 9q and partial monosomy 8q.

  16. Two types of q-deformed Wigner algebra

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Won Sang [Department of Physics and Research Institute of Natural Science, College of Natural Science, Gyeongsang National University, Jinju (Korea, Republic of)

    2014-07-01

    In this paper we introduce two types of q-deformed Wigner algebras. One is q-deformation of Wigner algebra with q-reflection symmetry and another is q-deformation of Wigner algebra with reflection symmetry. For two types of q-deformed Wigner algebras, we investigate the representation and the eigenvalue of the position operator. Like q-calculus, we introduce the (q; ν)- numbers, (q; ν)-derivatives and (q; ν)-Hermite polynomials for two algebras. For the deformation parameter q = 1 - ε with small ε, we discuss the thermodynamics of the particle obeying the q-deformed Wigner algebra. (Copyright copyright 2014 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  17. A Quantitative Electrophysiological Biomarker of Duplication 15q11.2-q13.1 Syndrome

    Science.gov (United States)

    Frohlich, Joel; Senturk, Damla; Saravanapandian, Vidya; Golshani, Peyman; Reiter, Lawrence T.; Sankar, Raman; Thibert, Ronald L.; DiStefano, Charlotte; Huberty, Scott; Cook, Edwin H.; Jeste, Shafali S.

    2016-01-01

    Background Duplications of 15q11.2-q13.1 (Dup15q syndrome) are highly penetrant for autism spectrum disorder (ASD). A distinct electrophysiological (EEG) pattern characterized by excessive activity in the beta band has been noted in clinical reports. We asked whether EEG power in the beta band, as well as in other frequency bands, distinguished children with Dup15q syndrome from those with non-syndromic ASD and then examined the clinical correlates of this electrophysiological biomarker in Dup15q syndrome. Methods In the first study, we recorded spontaneous EEG from children with Dup15q syndrome (n = 11), age-and-IQ-matched children with ASD (n = 10) and age-matched typically developing (TD) children (n = 9) and computed relative power in 6 frequency bands for 9 regions of interest (ROIs). Group comparisons were made using a repeated measures analysis of variance. In the second study, we recorded spontaneous EEG from a larger cohort of individuals with Dup15q syndrome (n = 27) across two sites and examined age, epilepsy, and duplication type as predictors of beta power using simple linear regressions. Results In the first study, spontaneous beta1 (12–20 Hz) and beta2 (20–30 Hz) power were significantly higher in Dup15q syndrome compared with both comparison groups, while delta (1–4 Hz) was significantly lower than both comparison groups. Effect sizes in all three frequency bands were large (|d| > 1). In the second study, we found that beta2 power was significantly related to epilepsy diagnosis in Dup15q syndrome. Conclusions Here, we have identified an electrophysiological biomarker of Dup15q syndrome that may facilitate clinical stratification, treatment monitoring, and measurement of target engagement for future clinical trials. Future work will investigate the genetic and neural underpinnings of this electrophysiological signature as well as the functional consequences of excessive beta oscillations in Dup15q syndrome. PMID:27977700

  18. Chromosome 15q24 microdeletion syndrome

    Directory of Open Access Journals (Sweden)

    Magoulas Pilar L

    2012-01-01

    Full Text Available Abstract Chromosome 15q24 microdeletion syndrome is a recently described rare microdeletion syndrome that has been reported in 19 individuals. It is characterized by growth retardation, intellectual disability, and distinct facial features including long face with high anterior hairline, hypertelorism, epicanthal folds, downslanting palpebral fissures, sparse and broad medial eyebrows, broad and/or depressed nasal bridge, small mouth, long smooth philtrum, and full lower lip. Other common findings include skeletal and digital abnormalities, genital abnormalities in males, hypotonia, behavior problems, recurrent infections, and eye problems. Other less frequent findings include hearing loss, growth hormone deficiency, hernias, and obesity. Congenital malformations, while rare, can be severe and include structural brain anomalies, cardiovascular malformations, congenital diaphragmatic hernia, intestinal atresia, imperforate anus, and myelomeningocele. Karyotypes are typically normal, and the deletions were detected in these individuals by array comparative genomic hybridization (aCGH. The deletions range in size from 1.7-6.1 Mb and usually result from nonallelic homologous recombination (NAHR between paralogous low-copy repeats (LCRs. The majority of 15q24 deletions have breakpoints that localize to one of five LCR clusters labeled LCR15q24A, -B, -C, -D, and -E. The smallest region of overlap (SRO spans a 1.2 Mb region between LCR15q24B to LCR15q24C. There are several candidate genes within the SRO, including CYP11A1, SEMA7A, CPLX3, ARID3B, STRA6, SIN3A and CSK, that may predispose to many of the clinical features observed in individuals with 15q24 deletion syndrome. The deletion occurred as a de novo event in all of the individuals when parents were available for testing. Parental aCGH and/or FISH studies are recommended to provide accurate genetic counseling and guidance regarding prognosis, recurrence risk, and reproductive options. Management

  19. k and q Dedicated to Paul Callaghan

    Science.gov (United States)

    Blümich, Bernhard

    2016-06-01

    The symbols k and q denote wave numbers in scattering experiments as well as in NMR imaging. Their exploration in NMR is intimately linked to the legacy of Paul Callaghan with his books Magnetic Resonance Microscopy and Translational Dynamics & Magnetic Resonance (Oxford University Press, Oxford 1991 and 2011) placing their focus with their titles on k and q, respectively. Some aspects of k and q have been revisited in the Paul Callaghan lecture of the author at the ISMAR Conference in Shanghai in 2015, which are reviewed here. In particular, there are two definitions of q, one relating to diffusive displacement (q) and the other to coherent flow (qv). Concerning the latter, it turns out, that in the short gradient pulse limit, the common anti-phase pulsed field-gradient scheme can be replaced with schemes employing three and more gradient pulses, which derive from differentiation rules in numerical analysis. Practical gradient modulation schemes with finite gradient pulse widths follow from these to measure velocity with improved accuracy. This approach can be expanded to acceleration and higher order transport coefficients with applications to measurements of flow and potentially also restricted diffusion.

  20. Chromosome 11q13 deletion syndrome

    Science.gov (United States)

    Kim, Yu-Seon; Kim, Gun-Ha; Byeon, Jung Hye; Eun, So-Hee

    2016-01-01

    Chromosome 11q13 deletion syndrome has been previously reported as either otodental syndrome or oculo-oto-dental syndrome. The otodental syndrome is characterized by dental abnormalities and high-frequency sensorineural hearing loss, and by ocular coloboma in some cases. The underlying genetic defect causing otodental syndrome is a hemizygous microdeletion involving the FGF3 gene on chromosome 11q13.3. Recently, a new form of severe deafness, microtia (small ear) and small teeth, without the appearance of eye abnormalities, was also reported. In this report, we describe a 1-year-old girl presenting with ptosis of the left upper eyelid, right auricular deformity, high-arched palate, delayed dentition, simian line on the right hand, microcephaly, and developmental delay. In this patient, we identified a deletion in the chromosome 11q13.2-q13.3 (2.75 Mb) region by using an array-comparative genomic hybridization analysis. The deletion in chromosome 11q13 results in a syndrome characterized by variable clinical manifestations. Some of these manifestations involve craniofacial dysmorphology and require a functional workup for hearing, ophthalmic examinations, and long-term dental care. PMID:28018436

  1. Coenzyme Q10 and spinocerebellar ataxias.

    Science.gov (United States)

    Lo, Raymond Y; Figueroa, Karla P; Pulst, Stefan M; Lin, Chi-Ying; Perlman, Susan; Wilmot, George; Gomez, Christopher; Schmahmann, Jeremy; Paulson, Henry; Shakkottai, Vikram G; Ying, Sarah; Zesiewicz, Theresa; Bushara, Khalaf; Geschwind, Michael; Xia, Guangbin; Subramony, S H; Ashizawa, Tetsuo; Kuo, Sheng-Han

    2015-02-01

    The aim of this study was to investigate the association between drug exposure and disease severity in SCA types 1, 2, 3 and 6. The Clinical Research Consortium for Spinocerebellar Ataxias (CRC-SCA) enrolled 319 participants with SCA1, 2, 3, and 6 from 12 medical centers in the United States and repeatedly measured clinical severity by the Scale for Assessment and Rating of Ataxia (SARA), the Unified Huntington's Disease Rating Scale part IV (UHDRS-IV), and the 9-item Patient Health Questionnaire during July 2009 to May 2012. We employed generalized estimating equations in regression models to study the longitudinal effects of coenzyme Q10 (CoQ10), statin, and vitamin E on clinical severity of ataxia after adjusting for age, sex, and pathological CAG repeat number. Cross-sectionally, exposure to CoQ10 was associated with lower SARA and higher UHDRS-IV scores in SCA1 and 3. No association was found between statins, vitamin E, and clinical outcome. Longitudinally, CoQ10, statins, and vitamin E did not change the rates of clinical deterioration indexed by SARA and UHDRS-IV scores within 2 years. CoQ10 is associated with better clinical outcome in SCA1 and 3. These drug exposures did not appear to influence clinical progression within 2 years. Further studies are warranted to confirm the association.

  2. Clinical researches of coenzyme Q10 in diabetes mellitus%辅酶Q10在糖尿病中的研究及临床应用进展

    Institute of Scientific and Technical Information of China (English)

    王曦; 任艳

    2010-01-01

    Coenzyme Q10(CoQ10)acts as a necessary part for oxidative phosphorylation and the synthesis of ATP.It has been confirmed so far as the effective treatment to mitochondrial diabetes mellitus.Studies suggest that CoQ10 supplements not only improve insulin resistance and cellular mitochondrial respiration by decreasing oxidative stress,but also attenuate atherosclerosis by reacting with oxygen radicals,reducing lipid peroxidation,and enhancing the synthesis of NO.Furthermore,CoQ10 can also mitigate side effects caused by statins,and co-activate PPAR α with fibrates to enhance its hypolipidemic effect.CoQ10 appears most promising for the prevention and delay of diabetes and its complications.%辅酶Q10(CoQ10)在细胞氧化磷酸化及ATP产生过程中起关键作用,是目前证实治疗线粒体糖尿病有效的药物.研究发现补充CoQ10不仅能通过减轻氧化应激来改善胰岛素抵抗、保护线粒体功能,而且还能通过清除氧自由基、抑制脂质过氧化、增加一氧化氮的合成来对抗动脉粥样硬化.此外,CoQ10还能减轻他汀类药物的不良反应、协同贝特类药物激活过氧化物酶体增殖物活化受体(PPAR)α,达到辅助降脂的同的.CoQ10可为预防及延缓糖尿病及其并发症提供新的治疗方法 .

  3. Mitochondria-Targeted Antioxidant SkQ1 Improves Dermal Wound Healing in Genetically Diabetic Mice.

    Science.gov (United States)

    Demyanenko, Ilya A; Zakharova, Vlada V; Ilyinskaya, Olga P; Vasilieva, Tamara V; Fedorov, Artem V; Manskikh, Vasily N; Zinovkin, Roman A; Pletjushkina, Olga Yu; Chernyak, Boris V; Skulachev, Vladimir P; Popova, Ekaterina N

    2017-01-01

    Oxidative stress is widely recognized as an important factor in the delayed wound healing in diabetes. However, the role of mitochondrial reactive oxygen species in this process is unknown. It was assumed that mitochondrial reactive oxygen species are involved in many wound-healing processes in both diabetic humans and animals. We have applied the mitochondria-targeted antioxidant 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to explore the role of mitochondrial reactive oxygen species in the wound healing of genetically diabetic mice. Healing of full-thickness excisional dermal wounds in diabetic C57BL/KsJ-db(-)/db(-) mice was significantly enhanced after long-term (12 weeks) administration of SkQ1. SkQ1 accelerated wound closure and stimulated epithelization, granulation tissue formation, and vascularization. On the 7th day after wounding, SkQ1 treatment increased the number of α-smooth muscle actin-positive cells (myofibroblasts), reduced the number of neutrophils, and increased macrophage infiltration. SkQ1 lowered lipid peroxidation level but did not change the level of the circulatory IL-6 and TNF. SkQ1 pretreatment also stimulated cell migration in a scratch-wound assay in vitro under hyperglycemic condition. Thus, a mitochondria-targeted antioxidant normalized both inflammatory and regenerative phases of wound healing in diabetic mice. Our results pointed to nearly all the major steps of wound healing as the target of excessive mitochondrial reactive oxygen species production in type II diabetes.

  4. A dramatic increase of C1q protein in the CNS during normal aging.

    Science.gov (United States)

    Stephan, Alexander H; Madison, Daniel V; Mateos, José María; Fraser, Deborah A; Lovelett, Emilie A; Coutellier, Laurence; Kim, Leo; Tsai, Hui-Hsin; Huang, Eric J; Rowitch, David H; Berns, Dominic S; Tenner, Andrea J; Shamloo, Mehrdad; Barres, Ben A

    2013-08-14

    The decline of cognitive function has emerged as one of the greatest health threats of old age. Age-related cognitive decline is caused by an impacted neuronal circuitry, yet the molecular mechanisms responsible are unknown. C1q, the initiating protein of the classical complement cascade and powerful effector of the peripheral immune response, mediates synapse elimination in the developing CNS. Here we show that C1q protein levels dramatically increase in the normal aging mouse and human brain, by as much as 300-fold. This increase was predominantly localized in close proximity to synapses and occurred earliest and most dramatically in certain regions of the brain, including some but not all regions known to be selectively vulnerable in neurodegenerative diseases, i.e., the hippocampus, substantia nigra, and piriform cortex. C1q-deficient mice exhibited enhanced synaptic plasticity in the adult and reorganization of the circuitry in the aging hippocampal dentate gyrus. Moreover, aged C1q-deficient mice exhibited significantly less cognitive and memory decline in certain hippocampus-dependent behavior tests compared with their wild-type littermates. Unlike in the developing CNS, the complement cascade effector C3 was only present at very low levels in the adult and aging brain. In addition, the aging-dependent effect of C1q on the hippocampal circuitry was independent of C3 and unaccompanied by detectable synapse loss, providing evidence for a novel, complement- and synapse elimination-independent role for C1q in CNS aging.

  5. Characterization of a balanced reciprocal translocation, rcp(9;11)(q27;q11) in cattle.

    Science.gov (United States)

    De Lorenzi, L; De Giovanni, A; Molteni, L; Denis, C; Eggen, A; Parma, P

    2007-01-01

    Cytogenetic analysis of a phenotypically normal young bull from Marchigiana breed revealed the presence of an abnormal karyotype. The observation of longer and smaller chromosomes than BTA1 and BTA29, respectively in all metaphases suggested the presence of a reciprocal translocation. RBG-banding confirmed this hypothesis revealing the involvement of BTA9 and BTA11. FISH analyses using cattle-specific BAC clones (474A12 and 293G09 for BTA9; 035D03 for BTA11) identified rcp(9;11)(q27;q11) in the two regions affected. Moreover analyses performed on both parents established the 'de novo' origin of the anomaly. Comparison with human homologue sequences (HSA6q24.3-->q25.3 for BTA9q27 and HSA2q11.1-->q12.1 for BTA11q11) revealed that both breakpoint regions are gene rich as up to date at least 200 genes have been localized in these regions. Thus, further analyses are required to identify the sequences disrupted by the breakpoints and to verify their consequences on rcp carrier phenotype. Copyright (c) 2008 S. Karger AG, Basel.

  6. Permutations with Kazhdan-Lusztig polynomial P_{id,w}(q) = 1 + q^h

    OpenAIRE

    Woo, Alexander; Billey, Sara; Weed, Jonathan

    2008-01-01

    Using resolutions of singularities introduced by Cortez and a method for calculating Kazhdan-Lusztig polynomials due to Polo, we prove the conjecture of Billey and Braden characterizing permutations w with Kazhdan-Lusztig polynomial P_{id,w}(q)=1+q^h for some h.

  7. Interstitial duplications of chromosome region 15q11q13 : Clinical and molecular characterization

    NARCIS (Netherlands)

    Repetto, GR; White, LM; Bader, PJ; Johnson, D; Knoll, JHM

    1998-01-01

    Duplications of chromosome region 15q11q13 often occur as a supernumerary chromosome 15. Less frequently they occur as interstitial duplications [dup(15)]. We describe the clinical and molecular characteristics of three patients with de novo dup(15). The patients, two males and one female (ages 3-21

  8. Linkage of atopic dermatitis to chromosomes 4q22, 3p24 and 3q21

    DEFF Research Database (Denmark)

    Christensen, Ulla; Møller-Larsen, Steffen; Nyegaard, Mette

    2009-01-01

    Atopic dermatitis (AD) is a common, itchy skin disease of complex inheritance characterized by dermal and epidermal inflammation. The heritability is considerable and well documented. To date, four genome scans have examined the AD phenotype, showing replicated linkage at 3p26-22, 3q13-21 and 18q11...

  9. The algebra of q-pseudodifferential symbols and the q-W$_{KP}^{n}$ algebra

    CERN Document Server

    Mas, J; Mas, Javier; Seco, Marcos

    1995-01-01

    We construct q-deformations of the W_KP and related W-type algebras. These algebras arise as Gelfand-Dickey brackets on the space of q-pseudodifferential symbols. The construction establishes a continuous correspondence between the Toda lattice and the KP hierarchy at the level of their hamiltonian structures

  10. The $q\\overline{q}$ relativistic interaction in the Wilson loop approach

    CERN Document Server

    Brambilla, Nora; Brambilla, Nora; Vairo, Antonio

    1997-01-01

    We study the $q \\bar{q}$ relativistic interaction starting from the Feynman-Schwinger representation of the gauge-invariant quark-antiquark Green function. We focus on the one-body limit and discuss the obtained non-perturbative interaction kernel of the Dirac equation.

  11. The $q \\bar{q}$ relativistic interaction in the Wilson loop approach

    OpenAIRE

    Brambilla, Nora; Vairo, Antonio

    1997-01-01

    We study the $q \\bar{q}$ relativistic interaction starting from the Feynman-Schwinger representation of the gauge-invariant quark-antiquark Green function. We focus on the one-body limit and discuss the obtained non-perturbative interaction kernel of the Dirac equation.

  12. (m, n)-string in (p, q)-string and (p, q)-five-brane background

    Energy Technology Data Exchange (ETDEWEB)

    Kluson, Josef [Masaryk University, Department of Theoretical Physics and Astrophysics, Faculty of Science, Brno (Czech Republic)

    2016-11-15

    We study dynamics of (m, n)-string in (p, q)-five-brane and (p, q)-string background. We determine world-volume stress energy tensor and we analyze the dependence of the string's dynamics on the values of the charges (m, n) and the value of the angular momentum. (orig.)

  13. Interstitial duplications of chromosome region 15q11q13 : Clinical and molecular characterization

    NARCIS (Netherlands)

    Repetto, GR; White, LM; Bader, PJ; Johnson, D; Knoll, JHM

    1998-01-01

    Duplications of chromosome region 15q11q13 often occur as a supernumerary chromosome 15. Less frequently they occur as interstitial duplications [dup(15)]. We describe the clinical and molecular characteristics of three patients with de novo dup(15). The patients, two males and one female (ages 3-21

  14. Comparison of q anti qg and q anti q. gamma. events in e/sup +/e/sup -/ annihilation at PEP

    Energy Technology Data Exchange (ETDEWEB)

    Hofmann, W.

    1986-07-01

    In comparing the particle flow in the event plane of three-jet (q anti qg) events and of radiative annihilation events (q anti q..gamma..) for similar kinematic configurations, two PEP experiments find a significant decrease in particle density in the angular region opposite to the gluon jet in q anti qg events, relative to the particle density in the region opposite to the photon in q anti q..gamma.. events. The effect is predicted both by QCD and by phenomenological string models. 5 refs., 5 figs.

  15. An improved Q estimation approach: the weighted centroid frequency shift method

    Science.gov (United States)

    Li, Jingnan; Wang, Shangxu; Yang, Dengfeng; Dong, Chunhui; Tao, Yonghui; Zhou, Yatao

    2016-06-01

    Seismic wave propagation in subsurface media suffers from absorption, which can be quantified by the quality factor Q. Accurate estimation of the Q factor is of great importance for the resolution enhancement of seismic data, precise imaging and interpretation, and reservoir prediction and characterization. The centroid frequency shift method (CFS) is currently one of the most commonly used Q estimation methods. However, for seismic data that contain noise, the accuracy and stability of Q extracted using CFS depend on the choice of frequency band. In order to reduce the influence of frequency band choices and obtain Q with greater precision and robustness, we present an improved CFS Q measurement approach—the weighted CFS method (WCFS), which incorporates a Gaussian weighting coefficient into the calculation procedure of the conventional CFS. The basic idea is to enhance the proportion of advantageous frequencies in the amplitude spectrum and reduce the weight of disadvantageous frequencies. In this novel method, we first construct a Gauss function using the centroid frequency and variance of the reference wavelet. Then we employ it as the weighting coefficient for the amplitude spectrum of the original signal. Finally, the conventional CFS is adopted for the weighted amplitude spectrum to extract the Q factor. Numerical tests of noise-free synthetic data demonstrate that the WCFS is feasible and efficient, and produces more accurate results than the conventional CFS. Tests for noisy synthetic data indicate that the new method has better anti-noise capability than the CFS. The application to field vertical seismic profile (VSP) data further demonstrates its validity5.

  16. A Shortcut to the Q-Operator

    CERN Document Server

    Bazhanov, Vladimir V; Meneghelli, Carlo; Staudacher, Matthias

    2010-01-01

    Baxter's Q-operator is generally believed to be the most powerful tool for the exact diagonalization of integrable models. Curiously, it has hitherto not yet been properly constructed in the simplest such system, the compact spin-1/2 Heisenberg-Bethe XXX spin chain. Here we attempt to fill this gap and show how two linearly independent operatorial solutions to Baxter's TQ equation may be constructed as commuting transfer matrices if a twist field is present. The latter are obtained by tracing over infinitely many oscillator states living in the auxiliary channel of an associated monodromy matrix. We furthermore compare and differentiate our approach to earlier articles addressing the problem of the construction of the Q-operator for the XXX chain. Finally we speculate on the importance of Q-operators for the physical interpretation of recent proposals for the Y-system of AdS/CFT.

  17. Q-learning with censored data

    CERN Document Server

    Goldberg, Yair; 10.1214/12-AOS968

    2012-01-01

    We develop methodology for a multistage decision problem with flexible number of stages in which the rewards are survival times that are subject to censoring. We present a novel Q-learning algorithm that is adjusted for censored data and allows a flexible number of stages. We provide finite sample bounds on the generalization error of the policy learned by the algorithm, and show that when the optimal Q-function belongs to the approximation space, the expected survival time for policies obtained by the algorithm converges to that of the optimal policy. We simulate a multistage clinical trial with flexible number of stages and apply the proposed censored-Q-learning algorithm to find individualized treatment regimens. The methodology presented in this paper has implications in the design of personalized medicine trials in cancer and in other life-threatening diseases.

  18. Indecomposable U_q(sl_n) modules for q^h = -1 and BRS intertwiners

    CERN Document Server

    Furlan, Paolo; Todorov, I G; Furlan, Paolo; Hadjiivanov, Ludmil; Todorov, Ivan

    2001-01-01

    A class of indecomposable representations of U_q(sl_n) is considered for q an even root of unity (q^h = -1) exhibiting a similar structure as (height h) indecomposable lowest weight Kac-Moody modules associated with a chiral conformal field theory. In particular, U_q(sl_n) counterparts of the Bernard-Felder BRS operators are constructed for n=2,3. For n=2 a pair of dual d_2(h) = h dimensional U_q(sl_2) modules gives rise to a 2h-dimensional indecomposable representation including those studied earlier in the context of tensor product expansions of irreducible representations. For n=3 the interplay between the Poincare'-Birkhoff-Witt and (Lusztig) canonical bases is exploited in the study of d_3(h) = h(h+1)(2h+1)/6 dimensional indecomposable modules and of the corresponding intertwiners.

  19. Dual-loss-modulated Q-switched Tm:LuAG laser with AOM and monolayer graphene.

    Science.gov (United States)

    Luan, Chao; Yang, Ke Jian; Zhao, Jia; Zhao, Sheng Zhi; Qiao, Wen Chao; Li, Tao; Feng, Tian Li; Liu, Cheng; Qiao, Jun Peng; Zheng, Li He; Xu, Jun; Wang, Qing Guo; Su, Liang Bi

    2015-09-20

    A laser-diode-pumped dual-loss-modulated Q-switching Tm:LuAG laser with an acousto-optic modulator (AOM) and monolayer graphene saturable absorber (SA) around 2 μm is presented for the first time to the best of our knowledge. The average output power and the pulse widths for different repetition rates have been measured. In comparison with the singly Q-switching laser with AOM or with monolayer graphene SA, the dual-loss-modulated Q-switching laser could generate shorter pulse width and higher peak power. The maximum pulse width compression ratio was found to be 3.11, and the highest peak power was enhanced 97.4 times. The experimental results show that the dual-loss-modulated technology is an efficient method for compressing the pulse width, improving the peak power, and enhancing the pulse stability for the Q-switched lasers at 2 μm.

  20. Loss of heterozygosity on chromosome 10q22-10q23 and 22q 11.2-22q12.1 and p53 gene in primary hepatocellular carcinoma

    Institute of Scientific and Technical Information of China (English)

    Guang-Neng Zhu; Li Zuo; Qing Zhou; Su-Mei Zhang; Hua-Qing Zhu; Shu-Yu Gui; Yuan Wang

    2004-01-01

    AIM: To analyze loss of heterozygosity (LOH) and homozygous deletion on p53 gene (exon2-3, 4 and 11), chromosome10q22-10q23 and 22q11.2 -22q12.1 in human hepatocellular carcinoma (HCC).METHODS: PCR and PCR-based microsatellite polymorphism analysis techniques were used.RESULTS: LOH was observed at D10S579 (10q22-10q23)in 4 of 20 tumors (20%), at D22S421 (22q11.2-22q12.1) in3 of 20(15%), at TP53.A (p53 gene exon 2-3) in 4 of 20(20%), at TP53.B (p53 gene exon 4) in 6 of 20(30%), and at TP53.G (p53gene exon 11)in 0 of 20(0%). Homozygous deletion was detected at 10q22-10q23(8/20; 40%), 22q11.2-22q12.1(8/20; 40%), p53 gene exon 2-3(0/20;0%), p53gene exon 4(6/20; 30%), and p53gene exon 11(2/20; 10%).CONCLUSION: There might be unidentified tumor suppressor genes on chromosome 10q22-10q23 and 22q11.2-22q12.1 that contribute to the pathogenesis and development of HCC.

  1. Representation of Spin Group Spin(p, q)

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The representation (&)(p, q) of spin group Spin(p, q) in any dimensional space is given by induction, and the relation between two representations, which are obtained in two kinds of inductions from Spin(p, q) to Spin(p + 1, q + 1)are studied.

  2. Harmonic Analysis Associated with the Generalized q-Bessel Operator

    Directory of Open Access Journals (Sweden)

    Ahmed Abouelaz

    2016-01-01

    Full Text Available In this article, we give a new harmonic analysis associated with the generalized q-Bessel operator. We introduce the generalized $q$-Bessel transform, the generalized q-Bessel translation and the generalized $q$-Bessel convolution product.

  3. Q board interviews: An effective method to research user opinions

    NARCIS (Netherlands)

    Wiegers, T.; De Lange, C.J.M.; Vergeest, J.S.M.

    2014-01-01

    Q board interviews can be applied as an effective method to get insight in the opinions of participants. Q board interviews form the interviewing part of Q methodology. Q methodology can be used to identify typical sets of opinions. However, in many studies, the research goal is to order opinions an

  4. Q board interviews: An effective method to research user opinions

    NARCIS (Netherlands)

    Wiegers, T.; De Lange, C.J.M.; Vergeest, J.S.M.

    2014-01-01

    Q board interviews can be applied as an effective method to get insight in the opinions of participants. Q board interviews form the interviewing part of Q methodology. Q methodology can be used to identify typical sets of opinions. However, in many studies, the research goal is to order opinions

  5. Chemistry and Molecular Dynamics Simulations of Heme b-HemQ and Coproheme-HemQ.

    Science.gov (United States)

    Hofbauer, Stefan; Dalla Sega, Marco; Scheiblbrandner, Stefan; Jandova, Zuzana; Schaffner, Irene; Mlynek, Georg; Djinović-Carugo, Kristina; Battistuzzi, Gianantonio; Furtmüller, Paul G; Oostenbrink, Chris; Obinger, Christian

    2016-09-27

    Recently, a novel pathway for heme b biosynthesis in Gram-positive bacteria has been proposed. The final poorly understood step is catalyzed by an enzyme called HemQ and includes two decarboxylation reactions leading from coproheme to heme b. Coproheme has been suggested to act as both substrate and redox active cofactor in this reaction. In the study presented here, we focus on HemQs from Listeria monocytogenes (LmHemQ) and Staphylococcus aureus (SaHemQ) recombinantly produced as apoproteins in Escherichia coli. We demonstrate the rapid and two-phase uptake of coproheme by both apo forms and the significant differences in thermal stability of the apo forms, coproheme-HemQ and heme b-HemQ. Reduction of ferric high-spin coproheme-HemQ to the ferrous form is shown to be enthalpically favored but entropically disfavored with standard reduction potentials of -205 ± 3 mV for LmHemQ and -207 ± 3 mV for SaHemQ versus the standard hydrogen electrode at pH 7.0. Redox thermodynamics suggests the presence of a pronounced H-bonding network and restricted solvent mobility in the heme cavity. Binding of cyanide to the sixth coproheme position is monophasic but relatively slow (∼1 × 10(4) M(-1) s(-1)). On the basis of the available structures of apo-HemQ and modeling of both loaded forms, molecular dynamics simulation allowed analysis of the interaction of coproheme and heme b with the protein as well as the role of the flexibility at the proximal heme cavity and the substrate access channel for coproheme binding and heme b release. Obtained data are discussed with respect to the proposed function of HemQ in monoderm bacteria.

  6. Steps toward increasing Q in mirror systems

    Energy Technology Data Exchange (ETDEWEB)

    Post, R.F.

    1979-08-20

    Experiments such as the 2XIIB experiment at Livermore have established the ability of mirror systems to confine high temperature, high density plasmas at central beta values exceeding unity. Given these results the next tasks for the mirror approach are to explore means for increasing the energy gain factor Q and to scale up the plasma volume, both of these requirements deriving from economic constraints. This report discusses means for increasng Q, including recent improvements in the tandem mirror concept and design studies of the field-reversed mirror in the context of upcoming and proposed scaled-up mirror experiments.

  7. Q-Balls with Scalar Charge

    Science.gov (United States)

    Levin, A.; Rubakov, V.

    We consider Friedberg-Lee-Sirlin Q-balls in a (3+1)-dimensional model with vanishing scalar potential of one of the fields. We show that, unlike in (2+1) and (1+1) dimensions, the Q-ball is stabilized by the gradient energy of this field and carries scalar charge, over and beyond the global charge. The latter property is also inherent in a model with the scalar potential that does not vanish in a finite field region near the origin.

  8. [Q fever, a zoonosis often overlooked].

    Science.gov (United States)

    Delaloye, J; Greub, G

    2013-04-24

    Q fever is a zoonosis caused by an intracellular Gram-negative bacteria, Coxiella burnetii. Animals are the main reservoir and transmission to men generally is occurring by inhalation of contaminated aerosols. Acute Q fever generally is benign and usually resolves spontaneously. When symptomatic, the clinical presentation typically includes one of the following three syndromes: a flu-like illness, a granulomatous hepatitis or an atypical pneumonia. Individuals presenting risk factors such as patients with valvular heart diseases and vascular prostheses, as well as pregnant women and immuno-suppressed patients represent a population at risk of chronic infection, with endocarditis as the most common clinical form.

  9. N*(1535) electroproduction at high Q2

    CERN Document Server

    Ramalho, G; Tsushima, K

    2011-01-01

    A covariant spectator quark model is applied to study the gamma N -> N*(1535) reaction in the large Q2 region. Starting from the relation between the nucleon and N*(1535) systems, the N*(1535) valence quark wave function is determined without the addition of any parameters. The model is then used to calculate the gamma N -> N*(1535) transition form factors. A very interesting, useful relation between the A12 and S12 helicity amplitudes for Q2 > GeV^2, is also derived.

  10. N*(1535) electroproduction at high Q2

    Energy Technology Data Exchange (ETDEWEB)

    G. Ramalho, M.T. Pena, K. Tsushima

    2012-04-01

    A covariant spectator quark model is applied to study the {gamma}N {yields} N*(1535) reaction in the large Q{sup 2} region. Starting from the relation between the nucleon and N*(1535) systems, the N*(1535) valence quark wave function is determined without the addition of any parameters. The model is then used to calculate the {gamma}N {yields} N*(1535) transition form factors. A very interesting, useful relation between the A{sub 1/2} and S{sub 1/2} helicity amplitudes for Q{sup 2} > GeV{sup 2}, is also derived.

  11. qq(q)→qq(q) Reaction in Quark-Gluon Matter%夸克胶子物质内的qq(q)→qq(q)反应

    Institute of Scientific and Technical Information of China (English)

    马成程; 许晓明

    2007-01-01

    夸克胶子物质内的从夸克-夸克-反夸克到夸克-夸克-反夸克的散射过程会影响夸克物质和反夸克物质的热平衡化,其散射振幅是研究热平衡化的一个基础.依据微扰QCD理论,编制Fortran程序,推导了α4s阶的各个qq(q)→qq(q)散射费曼图的振幅平方和不同费曼图间的干涉项.

  12. Biomedical Technology Assessment The 3Q Method

    CERN Document Server

    Weinfurt, Phillip

    2010-01-01

    Evaluating biomedical technology poses a significant challenge in light of the complexity and rate of introduction in today's healthcare delivery system. Successful evaluation requires an integration of clinical medicine, science, finance, and market analysis. Little guidance, however, exists for those who must conduct comprehensive technology evaluations. The 3Q Method meets these present day needs. The 3Q Method is organized around 3 key questions dealing with 1) clinical and scientific basis, 2) financial fit and 3) strategic and expertise fit. Both healthcare providers (e.g., hospitals) an

  13. Multi-indexed (q)-Racah Polynomials

    CERN Document Server

    Odake, Satoru

    2012-01-01

    As the second stage of the project $multi-indexed orthogonal polynomials$, we present, in the framework of `discrete quantum mechanics' with real shifts in one dimension, the multi-indexed (q)-Racah polynomials. They are obtained from the (q)-Racah polynomials by multiple application of the discrete analogue of the Darboux transformations or the Crum-Krein-Adler deletion of `virtual state' vectors of type I and II, in a similar way to the multi-indexed Laguerre and Jacobi polynomials reported earlier. The virtual state vectors are the `solutions' of the matrix Schr\\"odinger equation with negative `eigenvalues', except for one of the two boundary points.

  14. (Q,S,s) Pricing Rules

    OpenAIRE

    Kenneth Burdett; Guido Menzio

    2013-01-01

    We study the effect of menu costs on the pricing behavior of sellers and on the cross-sectional distribution of prices in the search-theoretic model of imperfect competition of Burdett and Judd (1983). We find that, when menu costs are small, the equilibrium is such that sellers follow a (Q, S, s) pricing rule. According to a (Q, S, s) rule, a seller lets inflation erode the real value of its nominal price until it reaches some point s. Then, the seller pays the menu cost and changes its nomi...

  15. Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training

    Directory of Open Access Journals (Sweden)

    Ragip Pala, Cemal Orhan, Mehmet Tuzcu, Nurhan Sahin, Shakir Ali, Vedat Cinar, Mustafa Atalay, Kazim Sahin

    2016-03-01

    Full Text Available This study reports the effects of Q10, coenzyme Q10 or ubiquinone, a component of the electron transport chain in mitochondria, on nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB, inhibitors of kappa B (IκB, nuclear factor (erythroid-derived 2-like 2 (Nrf2 and hemeoxygenase 1 (HO-1 in rats after chronic exercise training for 6 weeks. 8-week old male Wistar rats were assigned randomly to one of four treatments planned in a 2 x 2 factorial arrangement of two condition (sedentary vs. exercise training, and two coenzyme Q10 levels (0 and 300 mg/kg per day for 6 weeks. The expression levels of the target proteins were determined in the heart, liver and muscle, and biochemical parameters including creatinine, urea, glucose and lipid profile were investigated in plasma. When compared with sedentary group, significant decreases in heart, liver and muscle NFκB levels by 45%, 26% and 44% were observed in Q10 supplemented rats after exercise training, respectively, while the inhibitory protein IκB increased by 179%, 111% and 127% in heart, liver and muscle tissues. Q10 supplementation caused an increase in Nrf2 (167%, 165% and 90% and HO-1 (107%, 156% and 114% after exercise training in heart, liver and muscle tissues (p < 0.05. No significant change was observed in any of the parameters associated with protein, carbohydrate and lipid metabolism, except that exercise caused a decrease in plasma triglyceride, which was further decreased by Q10. In conclusion, these results suggest that Q10 modulates the expression of NFκB, IκB, Nrf2 and HO-1 in exercise training, indicating an anti-inflammatory effect of Q10 and emphasizes its role in antioxidant defense.

  16. HYDRAULIC CONDUCTIVITY OF SALTSTONE FORMULATED USING 1Q11, 2Q11 AND 3Q11 TANK 50 SLURRY SAMPLES

    Energy Technology Data Exchange (ETDEWEB)

    Reigel, M.; Nichols, R.

    2012-06-27

    As part of the Saltstone formulation work requested by Waste Solidification Engineering (WSE), Savannah River National Laboratory (SRNL) was tasked with preparing Saltstone samples for fresh property analysis and hydraulic conductivity measurements using actual Tank 50 salt solution rather than simulated salt solution. Samples of low level waste salt solution collected from Tank 50H during the first, second, and third quarters of 2011 were used to formulate the Saltstone samples. The salt solution was mixed with premix (45 wt % slag, 45 wt % fly ash, and 10 wt % cement), in a ratio consistent with facility operating conditions during the quarter of interest. The fresh properties (gel, set, bleed) of each mix were evaluated and compared to the recommended acceptance criteria for the Saltstone Production Facility. ASTM D5084-03, Method C was used to measure the hydraulic conductivity of the Saltstone samples. The hydraulic conductivity of Saltstone samples prepared from 1Q11 and 2Q11 samples of Tank 50H is 4.2E-9 cm/sec and 2.6E-9 cm/sec, respectively. Two additional 2Q11 and one 3Q11 sample were not successfully tested due to the inability to achieve stable readings during saturation and testing. The hydraulic conductivity of the samples made from Tank 50H salt solution compare well to samples prepared with simulated salt solution and cured under similar conditions (1.4E-9 - 4.9E-8 cm/sec).

  17. Investigation of 15q11-q13, 16p11.2 and 22q13 CNVs in autism spectrum disorder Brazilian individuals with and without epilepsy.

    Directory of Open Access Journals (Sweden)

    Danielle P Moreira

    Full Text Available Copy number variations (CNVs are an important cause of ASD and those located at 15q11-q13, 16p11.2 and 22q13 have been reported as the most frequent. These CNVs exhibit variable clinical expressivity and those at 15q11-q13 and 16p11.2 also show incomplete penetrance. In the present work, through multiplex ligation-dependent probe amplification (MLPA analysis of 531 ethnically admixed ASD-affected Brazilian individuals, we found that the combined prevalence of the 15q11-q13, 16p11.2 and 22q13 CNVs is 2.1% (11/531. Parental origin could be determined in 8 of the affected individuals, and revealed that 4 of the CNVs represent de novo events. Based on CNV prediction analysis from genome-wide SNP arrays, the size of those CNVs ranged from 206 kb to 2.27 Mb and those at 15q11-q13 were limited to the 15q13.3 region. In addition, this analysis also revealed 6 additional CNVs in 5 out of 11 affected individuals. Finally, we observed that the combined prevalence of CNVs at 15q13.3 and 22q13 in ASD-affected individuals with epilepsy (6.4% was higher than that in ASD-affected individuals without epilepsy (1.3%; p<0.014. Therefore, our data show that the prevalence of CNVs at 15q13.3, 16p11.2 and 22q13 in Brazilian ASD-affected individuals is comparable to that estimated for ASD-affected individuals of pure or predominant European ancestry. Also, it suggests that the likelihood of a greater number of positive MLPA results might be found for the 15q13.3 and 22q13 regions by prioritizing ASD-affected individuals with epilepsy.

  18. Investigation of 15q11-q13, 16p11.2 and 22q13 CNVs in autism spectrum disorder Brazilian individuals with and without epilepsy.

    Science.gov (United States)

    Moreira, Danielle P; Griesi-Oliveira, Karina; Bossolani-Martins, Ana L; Lourenço, Naila C V; Takahashi, Vanessa N O; da Rocha, Kátia M; Moreira, Eloisa S; Vadasz, Estevão; Meira, Joanna Goes Castro; Bertola, Debora; O'Halloran, Eoghan; Magalhães, Tiago R; Fett-Conte, Agnes C; Passos-Bueno, Maria Rita

    2014-01-01

    Copy number variations (CNVs) are an important cause of ASD and those located at 15q11-q13, 16p11.2 and 22q13 have been reported as the most frequent. These CNVs exhibit variable clinical expressivity and those at 15q11-q13 and 16p11.2 also show incomplete penetrance. In the present work, through multiplex ligation-dependent probe amplification (MLPA) analysis of 531 ethnically admixed ASD-affected Brazilian individuals, we found that the combined prevalence of the 15q11-q13, 16p11.2 and 22q13 CNVs is 2.1% (11/531). Parental origin could be determined in 8 of the affected individuals, and revealed that 4 of the CNVs represent de novo events. Based on CNV prediction analysis from genome-wide SNP arrays, the size of those CNVs ranged from 206 kb to 2.27 Mb and those at 15q11-q13 were limited to the 15q13.3 region. In addition, this analysis also revealed 6 additional CNVs in 5 out of 11 affected individuals. Finally, we observed that the combined prevalence of CNVs at 15q13.3 and 22q13 in ASD-affected individuals with epilepsy (6.4%) was higher than that in ASD-affected individuals without epilepsy (1.3%; p<0.014). Therefore, our data show that the prevalence of CNVs at 15q13.3, 16p11.2 and 22q13 in Brazilian ASD-affected individuals is comparable to that estimated for ASD-affected individuals of pure or predominant European ancestry. Also, it suggests that the likelihood of a greater number of positive MLPA results might be found for the 15q13.3 and 22q13 regions by prioritizing ASD-affected individuals with epilepsy.

  19. Investigation of 15q11-q13, 16p11.2 and 22q13 CNVs in Autism Spectrum Disorder Brazilian Individuals with and without Epilepsy

    Science.gov (United States)

    Moreira, Danielle P.; Griesi-Oliveira, Karina; Bossolani-Martins, Ana L.; Lourenço, Naila C. V.; Takahashi, Vanessa N. O.; da Rocha, Kátia M.; Moreira, Eloisa S.; Vadasz, Estevão; Meira, Joanna Goes Castro; Bertola, Debora; Halloran, Eoghan O’; Magalhães, Tiago R.; Fett-Conte, Agnes C.; Passos-Bueno, Maria Rita

    2014-01-01

    Copy number variations (CNVs) are an important cause of ASD and those located at 15q11-q13, 16p11.2 and 22q13 have been reported as the most frequent. These CNVs exhibit variable clinical expressivity and those at 15q11-q13 and 16p11.2 also show incomplete penetrance. In the present work, through multiplex ligation-dependent probe amplification (MLPA) analysis of 531 ethnically admixed ASD-affected Brazilian individuals, we found that the combined prevalence of the 15q11-q13, 16p11.2 and 22q13 CNVs is 2.1% (11/531). Parental origin could be determined in 8 of the affected individuals, and revealed that 4 of the CNVs represent de novo events. Based on CNV prediction analysis from genome-wide SNP arrays, the size of those CNVs ranged from 206 kb to 2.27 Mb and those at 15q11-q13 were limited to the 15q13.3 region. In addition, this analysis also revealed 6 additional CNVs in 5 out of 11 affected individuals. Finally, we observed that the combined prevalence of CNVs at 15q13.3 and 22q13 in ASD-affected individuals with epilepsy (6.4%) was higher than that in ASD-affected individuals without epilepsy (1.3%; p<0.014). Therefore, our data show that the prevalence of CNVs at 15q13.3, 16p11.2 and 22q13 in Brazilian ASD-affected individuals is comparable to that estimated for ASD-affected individuals of pure or predominant European ancestry. Also, it suggests that the likelihood of a greater number of positive MLPA results might be found for the 15q13.3 and 22q13 regions by prioritizing ASD-affected individuals with epilepsy. PMID:25255310

  20. Monoidal structure of the category of u$_q^+$-modules

    OpenAIRE

    Gunnlaugsdottir, Elisabet

    2000-01-01

    We study the finite dimensional modules on the half-quantum group u_q^+ at a root of unity q, whose action can be extended to u_q (quotient of the quantized enveloping algebra of sl_2). We derive decomposition formulas of the tensor product of indecomposable u_q^+-modules, which includes the cases of the universal and the quantized universal enveloping algebra of sl_2 for q not a root of unity. We also prove that simple modules on u_q correspond exactly to the extendable non projective u_q^+-...

  1. TPGS-chitosome as an effective oral delivery system for improving the bioavailability of Coenzyme Q10.

    Science.gov (United States)

    Shao, Yating; Yang, Liang; Han, Hyo-Kyung

    2015-01-01

    This study aimed to design the chitosan coated TPGS liposome to enhance the bioavailability of Coenzyme Q10 (CoQ10). Optimization of formulation variables for the preparation of the liposome was performed and then three liposomal formulations (TPGS-liposome, TPGS-chitosome, chitosome) were prepared with narrow size distribution and high encapsulation efficiency. All of three liposomal formulations were stable at pH 1.2 and 7.0 for 24h without any significant drug leakage. Furthermore, chitosan-coated liposomes showed the strong mucoadhesive properties. All the tested liposomal formulations significantly enhanced the cellular uptake of CoQ10 as compared to the untreated drug. Particularly, TPGS-chitosome appeared to be most effective in improving the cellular uptake of CoQ10 in Caco-2 cells (about 30-folds greater than the untreated powder formulation). In oral pharmacokinetic studies, TPGS-chitosome enhanced the systemic exposure of CoQ10 by 3.4 folds as compared to the untreated powder and also displayed the extended drug release profile for up to 24h in rats. Compared to the untreated powder CoQ10, TPGS-chitosome significantly improved the antioxidant effect of CoQ10 and reduced the intracellular ROS level. In conclusion, TPGS-chitosome significantly enhanced the oral bioavailability of CoQ10 and prolonged drug release profile in rats, suggesting that TPGS-chitosome could be an effective oral delivery platform to improve the oral bioavailability of poorly absorbable drugs.

  2. Group Connectivity of Generalized q-trees%广义q-树的群连通度

    Institute of Scientific and Technical Information of China (English)

    郝荣霞; 李德明; 李赵祥

    2012-01-01

    设G是无向图,A是加法交换群,且A^*=A-0.如果G有一个定向D(G),对任何满足∑v∈(G)b(v)=0的函数b:V(G)→A,都存在函数f:E(G)→A^*使得在每个顶点v∈V(G),从v发出的所有边上的f总值减去进入v的所有边上的f总值恰等于b(v),则称G是A-连通的.群连通数为:Ag(G)=min{n:对任何满足|A|≥n的群A,G是A-连通的}.令q是正整数,广义q-树的定义是按下列递推形式给出的:最小的广义q-树是阶为q的完全图Kq;阶为n+1的广义q-树是由阶为他的广义q-树通过增加一个新顶点和连接此点与阶为他的广义q-树中任意给定的q个顶点得到的.本文对广义q-树G(q≥2)考察Ag(G),证明了如果G是阶n≥3的广义2-树或阶为n∈{3,4}的广义3-树或阶为4的广义4-树,则Ag(G)=4;如果G是阶为n≥5的广义q-树(q≥3),则Ag(G)=3.%Let G be an undirected graph, A be an (additive) abelian group and A^* = A - 0. A graph G is A-connected if G has an orientation D(G) such that for every function b,: V(G)→ A satisfying ∑v∈v(a) b(v) = 0, there is a function f : E(G) → A^* such that at each vertex v∈ V(G), the amount of f values on the edges directed out from v minus the amount of f values on the edges directed into v equals b(v). The group connectivity number Ag(G) = min{n : G is A-connected for every abelian group A with |A|≥n}. Let q be a positive integer. The generalized q-trees are defined by recursion: the smallest generalized q-tree is the complete graph Kq -with order q, and a generalized q-tree with order n + 1 where n ≥ q is obtained by adding a new vertex adjacent to q arbitrarily selected vertices of a generalized q-tree with order n. In this paper, we investigate Ag(G) for generalized q-trees G with q ≥ 2. We show that if G is a generalized 2-tree with order n 〉 3 or generalized 3-tree with order n E {3, 4} or generalized 4-tree

  3. Tomographic inversion of near-surface Q factor by combining surface and cross-hole seismic surveys

    Science.gov (United States)

    Li, Guo-Fa; Zheng, Hao; Zhu, Wen-Liang; Wang, Ming-Chao; Zhai, Tong-Li

    2016-03-01

    The estimation of the quality factor Q plays a fundamental role in enhancing seismic resolution via absorption compensation in the near-surface layer. We present a new geometry that can be used to acquire field data by combining surface and cross-hole surveys to decrease the effect of geophone coupling on Q estimation. In this study, we drilled number of receiver holes around the source hole, each hole has different depth and each geophone is placed geophones into the bottom of each receiver hole to avoid the effect of geophone coupling with the borehole wall on Q estimation in conventional cross-hole seismic surveys. We also propose a novel tomographic inversion of the Q factor without the effect of the source signature, and examine its stability and reliability using synthetic data. We estimate the Q factors of the near-surface layer in two different frequency bands using field data acquired in the Dagang Oilfield. The results show that seismic absorption in the near-surface layer is much greater than that in the subsurface strata. Thus, it is of critical practical importance to enhance the seismic solution by compensating for near-surface absorption. In addition, we derive different Q factors from two frequency bands, which can be treated, to some extent, as evidence of a frequency-dependent Q.

  4. The REC domain mediated dimerization is critical for FleQ from Pseudomonas aeruginosa to function as a c-di-GMP receptor and flagella gene regulator.

    Science.gov (United States)

    Su, Tiantian; Liu, Shiheng; Wang, Kang; Chi, Kaikai; Zhu, Deyu; Wei, Tiandi; Huang, Yan; Guo, Liming; Hu, Wei; Xu, Sujuan; Lin, Zong; Gu, Lichuan

    2015-10-01

    FleQ is an AAA+ ATPase enhancer-binding protein that regulates both flagella and biofilm formation in the opportunistic pathogen Pseudomonas aeruginosa. FleQ belongs to the NtrC subfamily of response regulators, but lacks the corresponding aspartic acid for phosphorylation in the REC domain (FleQ(R), also named FleQ domain). Here, we show that the atypical REC domain of FleQ is essential for the function of FleQ. Crystal structure of FleQ(R) at 2.3Å reveals that the structure of FleQ(R) is significantly different from the REC domain of NtrC1 which regulates gene expression in a phosphorylation dependent manner. FleQ(R) forms a novel active dimer (transverse dimer), and mediates the dimerization of full-length FleQ in an unusual manner. Point mutations that affect the dimerization of FleQ lead to loss of function of the protein. Moreover, a c-di-GMP binding site deviating from the previous reported one is identified through structure analysis and point mutations.

  5. Fuzzy Torus and q-Deformed Lie Algebra

    CERN Document Server

    Nakayama, R

    2006-01-01

    It will be shown that the defining relations for fuzzy torus and deformed (squashed) sphere proposed by J. Arnlind, et al (hep-th/0602290) can be rewriten as a new algebra which contains q-deformed commutators. The quantum parameter q (|q|=1) is a function of \\hbar. It is shown that the q --> 1 limit of the algebra with the parameter \\mu <0 describes fuzzy S^2 and that the squashed S^2 with q \

  6. On the Diophantine equation x^4-q^4=py^5

    CERN Document Server

    Savin, Diana

    2009-01-01

    In this paper we study the Diophantine equation $x^{4}-q^{4}=py^{5},$ with the following conditions: $p$ and $q$ are different prime natural numbers, $y$ is not divisible with $p$, $p\\equiv3$ (mod20), $q\\equiv4$ (mod5), $\\overline{p}$ is a generator of the group $(U(\\textbf{Z}_{q^{4}}),\\cdot)$, $(x,y)=1$, 2 is a 5-power residue mod $q$.

  7. A new three-way variant t(15;22;17)(q22;q11.2;q21) in acute promyelocytic leukemia.

    Science.gov (United States)

    Kato, Takayasu; Hangaishi, Akira; Ichikawa, Motoshi; Motokura, Toru; Takahashi, Tsuyoshi; Kurokawa, Mineo

    2009-03-01

    Acute promyelocytic leukemia (APL) is characterized by the t(15;17)(q22;q21), which results in the fusion of the promyelocytic leukemia (PML) gene at 15q22 with the retinoic acid alpha-receptor (RARA) at 17q21. We report the case of a 44-year-old man with APL carrying a new complex variant translocation (15;22;17). Karyotypic analysis with G-banding of bone marrow cells revealed t(15;22;17) (q22;q11.2;q21). Fluorescence in situ hybridization with a PML/RARA dual-color DNA probe showed the fusion signals. RT-PCR analysis showed long-form PML/RARA fusion transcripts. A complete remission was attained with a course of conventional chemotherapy with all-trans retinoic acid (ATRA). This is the first report of a new three-way translocation of 22q11 involvement with APL.

  8. Maintaining high-Q in an optical microresonator coated with high-aspect-ratio gold nanorods

    Science.gov (United States)

    Ganta, D.; Dale, E. B.; Rosenberger, A. T.

    2013-10-01

    We report methods to coat fused-silica microresonators with solution-grown high-aspect-ratio (AR) gold nanorods (NRs). Microresonators coated using our method maintain an optical quality factor (Q) greater than 107 after coating. The more successful method involves silanization of the surface of the microresonator with 3-mercaptopropylmethyldimethoxysilane (MPMDMS), to enable the adhesion of gold NRs. The high-AR NR-coated microresonator combines the field enhancement of localized surface plasmon resonances with the cavity-enhanced evanescent components of high-Q whispering-gallery modes, making it useful for plasmonic sensing applications in the infrared. By coating with NRs having a different aspect ratio, the enhancement regime can be selected within a wide range of wavelengths.

  9. Retracted: 'A model of abusive supervision, self-efficacy and work engagement among Registered Nurses: the mediating role of self-efficacy' by Lv D.-M., Zheng Q.-L., Sun N., Li Q.-J., Fan Y.-Y., Hong S. & Liu S.-Q.

    Science.gov (United States)

    2016-12-01

    The above article, published in the Journal of Advanced Nursing on 21st July2016 on Early View, Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement of the journal Editor-in-Chief, Prof. Roger Watson, and John Wiley & Sons Ltd. The article has been retracted due to significant overlap with the following article published in the Journal of Nursing Management. Fan Y., Zheng Q., Liu S. & Li Q. (2016) Construction of a new model of job engagement, psychological empowerment and perceived work environment among Chinese registered nurses at four large university hospitals: implications for nurse managers seeking to enhance nursing retention and quality of care. Journal of Nursing Management 24(5), 646-655. Fan Y., Zheng Q., Liu S. & Li Q. (2016) Construction of a new model of job engagement, psychological empowerment and perceived work environment among Chinese registered nurses at four large university hospitals: implications for nurse managers seeking to enhance nursing retention and quality of care. Journal of Nursing Management 24(5), 646-655. Lv D.-M., Zheng Q.-L., Sun N., Li Q.-J., Fan Y.-Y., Hong S. & Liu S.-Q. (2016) A model of abusive supervision, self-efficacy and work engagement among Registered Nurses: the mediating role of self-efficacy. Journal of Advanced Nursing 72(12), 3216. doi:10.1111/jan.13057. © 2016 John Wiley & Sons Ltd.

  10. Coenzyme Q10 Supplementation Modulates NFκB and Nrf2 Pathways in Exercise Training.

    Science.gov (United States)

    Pala, Ragip; Orhan, Cemal; Tuzcu, Mehmet; Sahin, Nurhan; Ali, Shakir; Cinar, Vedat; Atalay, Mustafa; Sahin, Kazim

    2016-03-01

    This study reports the effects of Q10, coenzyme Q10 or ubiquinone, a component of the electron transport chain in mitochondria, on nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), inhibitors of kappa B (IκB), nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and hemeoxygenase 1 (HO-1) in rats after chronic exercise training for 6 weeks. 8-week old male Wistar rats were assigned randomly to one of four treatments planned in a 2 x 2 factorial arrangement of two condition (sedentary vs. exercise training), and two coenzyme Q10 levels (0 and 300 mg/kg per day for 6 weeks). The expression levels of the target proteins were determined in the heart, liver and muscle, and biochemical parameters including creatinine, urea, glucose and lipid profile were investigated in plasma. When compared with sedentary group, significant decreases in heart, liver and muscle NFκB levels by 45%, 26% and 44% were observed in Q10 supplemented rats after exercise training, respectively, while the inhibitory protein IκB increased by 179%, 111% and 127% in heart, liver and muscle tissues. Q10 supplementation caused an increase in Nrf2 (167%, 165% and 90%) and HO-1 (107%, 156% and 114%) after exercise training in heart, liver and muscle tissues (p < 0.05). No significant change was observed in any of the parameters associated with protein, carbohydrate and lipid metabolism, except that exercise caused a decrease in plasma triglyceride, which was further decreased by Q10. In conclusion, these results suggest that Q10 modulates the expression of NFκB, IκB, Nrf2 and HO-1 in exercise training, indicating an anti-inflammatory effect of Q10 and emphasizes its role in antioxidant defense. Key pointsCoenzyme Q10 is a component of the electron transport chain in mitochondria which is linked to the generation of energy in the cell.Coenzyme Q10 may inhibit the peroxidation of lipids, thus acting as an antioxidant and protects tissue against oxidative injury.Using of coenzyme Q

  11. Female pseudohermaphroditism in a fetus with a deletion 9(q22.2q31.1).

    Science.gov (United States)

    L'Herminé, A Coulomb; Aboura, A; Simon-Bouy, B; Robin, F; Audibert, F; Strouk, N; Capron, F; Frydman, R; Tachdjian, G

    2002-08-01

    Interstitial deletions of chromosomal region 9q are rarely seen. We report the first prenatal diagnosis of a de novo interstitial deletion 9q. The fetus was karyotyped for intrauterine growth retardation (IUGR). Conventional and molecular cytogenetics showed female karyotype with a de novo deletion of the chromosomal region 9(q22.2q31.1) leading to a partial monosomy 9q. At autopsy, the fetus showed growth retardation, dysmorphy, and a female pseudohermaphroditism. These results suggest that a gene(s) for genital development reside in chromosomal region 9q22.2q31.1. Copyright 2002 John Wiley & Sons, Ltd.

  12. New multi-level codes over GF(q)

    Science.gov (United States)

    Wu, Jiantian; Costello, Daniel J., Jr.

    1990-01-01

    Set partitioning to multi-dimensional signal spaces over GF(q), particularly GF sup q-1(q) and GF sup q (q), and show how to construct both multi-level block codes and multi-level trellis codes over GF(q). Two classes of multi-level (n, k, d) block codes over GF(q) with block length n, number of information symbols k, and minimum distance d sub min greater than or = d, are presented. These two classes of codes use Reed-Solomon codes as component codes. They can be easily decoded as block length q-1 Reed-Solomon codes or block length q or q + 1 extended Reed-Solomon codes using multi-stage decoding. Many of these codes have larger distances than comparable q-ary block codes, as component codes. Low rate q-ary convolutional codes, work error correcting convolutional codes, and binary-to-q-ary convolutional codes can also be used to construct multi-level trellis codes over GF(q) or binary-to-q-ary trellis codes, some of which have better performance than the above block codes. All of the new codes have simple decoding algorithms based on hard decision multi-stage decoding.

  13. Molecular cytogenetic characterization of a 2q35-q37 duplication and a 4q35.1-q35.2 deletion in two cousins: a genotype-phenotype analysis.

    Science.gov (United States)

    Ronzoni, Luisa; Peron, Angela; Bianchi, Vera; Baccarin, Marco; Guerneri, Silvana; Silipigni, Rosamaria; Lalatta, Faustina; Bedeschi, Maria Francesca

    2015-07-01

    The 2q3 duplication and 4q3 deletion are two distinct conditions with variable phenotypes including developmental delay, intellectual disability, Pierre Robin sequence (PRS), and cardiovascular, craniofacial, digital and skeletal anomalies. We describe two cousins, a 37-year-old man (Patient 1) and a 17-year-old girl (Patient 2), with a derivative chromosome leading to a 4q35 deletion-2q35q37 duplication. Conventional karyotype showed in both patients the same rearrangement derived from unbalanced segregation of a parental reciprocal translocation involving the long arms of chromosome 2 and 4. Patient 1's father and Patient 2's mother were identified as the carriers of a balanced translocation t(2;4)(q35;q35). Array-CGH analysis, performed to characterize the rearrangement, documented in both patients the presence of a 26 Mb duplication of the 2q35-q37.3 region of chromosome 2 and a 6.3 Mb deletion of the 4q35.1-q35.2 region of chromosome 4. Both patients showed intellectual disability, minor facial, and digital anomalies, hearing, ocular, and genitourinary abnormalities. The comparison of their features with those of published cases of 2q3 duplication and 4q3 deletion allowed us to further delineate the genotype-phenotype correlation as well as the combined effect of partial 2q duplication and 4q deletion syndromes in adulthood.

  14. Extended q-Gaussian and q-exponential distributions from gamma random variables.

    Science.gov (United States)

    Budini, Adrián A

    2015-05-01

    The family of q-Gaussian and q-exponential probability densities fit the statistical behavior of diverse complex self-similar nonequilibrium systems. These distributions, independently of the underlying dynamics, can rigorously be obtained by maximizing Tsallis "nonextensive" entropy under appropriate constraints, as well as from superstatistical models. In this paper we provide an alternative and complementary scheme for deriving these objects. We show that q-Gaussian and q-exponential random variables can always be expressed as a function of two statistically independent gamma random variables with the same scale parameter. Their shape index determines the complexity q parameter. This result also allows us to define an extended family of asymmetric q-Gaussian and modified q-exponential densities, which reduce to the standard ones when the shape parameters are the same. Furthermore, we demonstrate that a simple change of variables always allows relating any of these distributions with a beta stochastic variable. The extended distributions are applied in the statistical description of different complex dynamics such as log-return signals in financial markets and motion of point defects in a fluid flow.

  15. QTL Information Table: 199 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available 18 CDO455 pha Luo, L.J., Li, Z.K., Mei, H.W., Shu, Q.Y., Tabien, R., Zhong, D.B., Ying, C.S., Stansel, J.W.,...ding Depression and Heterosis in Rice. II. Grain Yield Components. Genetics 158, 1755-1771. http://www.genetics.org/cgi/content/abstract/158/4/1755 ...

  16. QTL Information Table: 424 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qPH7-2 Morphological trait Dwarf plant height RFLP C)Interval RIL Zhong 156 Gumei 2...3). Analysis of additive and AE interaction effects of QTLs controlling plant height, heading date and panicle number in rice (Oryza sativa L.). Yi Chuan Xue Bao 30, 899-906. ...

  17. QTL Information Table: 676 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qPH-11-1 Morphological trait Dwarf Plant height SSR C)Interval RIL Zhenshan 97 Ming.... Molecular dissection of developmental behavior of tiller number and plant height and their relationship in rice (Oryza sativa L.). Hereditas 143, 236-245. ...

  18. QTL Information Table: 456 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qOVA-5-2 Resistance or Tolerance Insect resistance whitebacked planthopper RFLP C)I...g egg mortality of whitebacked planthopper, Sogatella furcifera Horvath in rice, Oryza sativa L. Rice Genetics Newsletter 17, 87-89. ... ...nterval Asominori IR24 C1268 rgn Yamasaki, M., Yoshimura, A., and Yasui, H. (2000). Mapping of QTLs affectin

  19. QTL Information Table: 771 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qGC-6 Physiological trait Eating quality Gel consistency SSR C)Interval DHL Wuyujin...apping quantitative trait loci underlying the cooking and eating quality of rice using a DH population Molecular Breeding 15, 117-124. ...

  20. QTL Information Table: 775 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qVE-6 Physiological trait Eating quality volume expansion SSR C)Interval DHL Wuyuji...Mapping quantitative trait loci underlying the cooking and eating quality of rice using a DH population Molecular Breeding 15, 117-124. ...

  1. QTL Information Table: 773 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qWA-6 Physiological trait Eating quality Water absorption SSR C)Interval DHL Wuyuji...Mapping quantitative trait loci underlying the cooking and eating quality of rice using a DH population Molecular Breeding 15, 117-124. ...

  2. QTL Information Table: 770 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qAC-6 Physiological trait Eating quality Amylose content SSR C)Interval DHL Wuyujin...apping quantitative trait loci underlying the cooking and eating quality of rice using a DH population Molecular Breeding 15, 117-124. ...

  3. QTL Information Table: 1034 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qCDS-7 Physiological trait Source activity chlorophyll degradation speed RFLP C)Int...ng, Y.J. (2007). Mapping of QTLs controlling leaf chlorphyll content and chlorphyll degradation speed of detached leaves in rice. Fen Zi Xi Bao Sheng Wu Xue Bao 40, 346-350. ...

  4. QTL Information Table: 701 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qLTG-7 Resistance or Tolerance Cold tolerance low temperature germinability RFLP C)...imura, A. (2004). Inheritance and QTL mapping of low temperature germinability in rice (Oryza sativa L.). Yi Chuan Xue Bao 31, 701-706. ...

  5. QTL Information Table: 878 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Pi37 Resistance or Tolerance Blast resistance blast resistance A)Physical DQ92349.1...,B1100D10 pha Lin, F., Chen, S., Que, Z., Wang, L., Liu, X., and Pan, Q. (2007). The blast resistance gene P

  6. Anti-C1q autoantibodies

    NARCIS (Netherlands)

    Kallenberg, Cees G. M.

    2008-01-01

    Autoantibodies to complement components are associated with various diseases. Anti-C1q antibodies are present in all patients with hypocomplementemic urticarial vasculitis, but also, with varying prevalence, in other conditions. In SLE, these antibodies are neither sensitive nor specific for this co

  7. Thermal Loss in High-Q Antennas

    DEFF Research Database (Denmark)

    Barrio, Samantha Caporal Del; Bahramzy, Pevand; Svendsen, Simon

    2014-01-01

    Tunable antennas are very promising for future generations of mobile communications, where antennas are required to cover a wide range operating bands. This letter aims at characterizing the loss mechanism of tunable antennas. Tunable antennas typically exhibit a high Quality factor (Q), which can...

  8. ON PROPERTIES OF q-DIFFERENCE EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    Zheng Xiumin; Chen Zongxuan

    2012-01-01

    In this article,we consider some type of q-difference equations,which have meromorphic solutions with Borel exceptional zeros and poles.We also give a precise result in the finite order case and some further results in a particular case where qi =qi.

  9. QTL Information Table: 228 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available i 63 B C547 C2340 pha Xing, Z., Tan, F., Hua, P., Sun, L., Xu, G., and Zhang, Q. (2002). Characterization of the main effects..., epistatic effects and their environmental interactions of QTLs on the genetic basis of yield traits in rice. Theor Appl Genet 105, 248-257. ...

  10. QTL Information Table: 188 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available 30 RZ801 pha Cao, G.Q., Zhu, J., He, C.X., Gao, Y.M., and Wu, P. (2001). QTL analysis for epistatic effects ...and QTL x environment interaction effects on final height of rice (Oryza sativa L.). Yi Chuan Xue Bao 28, 135-143. ...

  11. QTL Information Table: 37 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available g, Q., and Xing, Y. (2006). Quantitative trait loci for panicle size, heading date and plant height co-segregating in trait-performan...ce derived near-isogenic lines of rice (Oryza sativa). Theor Appl Genet 113, 361-368. ...

  12. Q-Switching in a Neodymium Laser

    Science.gov (United States)

    Holgado, Warein; Sola, Inigo J.; Jarque, Enrique Conejero; Jarabo, Sebastian; Roso, Luis

    2012-01-01

    We present a laboratory experiment for advanced undergraduate or graduate laser-related classes to study the performance of a neodymium laser. In the experiment, the student has to build the neodymium laser using an open cavity. After that, the cavity losses are modulated with an optical chopper located inside, so the Q-switching regime is…

  13. Turbulence in a cusp Q device

    DEFF Research Database (Denmark)

    D'Angelo, N.; Pécseli, Hans; Petersen, P. I.

    1974-01-01

    Spectral measurements are reported of plasma turbulence in the Cs plasma of a Q device, modified to a magnetic cusp geometry. The excitation mechanism for the fluctuations appears to be the centrifugal instability discussed by Chen. A transition from an f−5 to an f−3 power spectrum is observed...

  14. Quality Metric Development Framework (qMDF

    Directory of Open Access Journals (Sweden)

    K. Mustafa

    2005-01-01

    Full Text Available Several object-oriented metrics have been developed and used in conjunction with the quality models to predict the overall quality of software. However, it may not be enough to propose metrics. The fundamental question may be of their validity, utility and reliability. It may be much significant to be sure that these metrics are really useful and for that their construct validity must be assured. Thereby, good quality metrics must be developed using a foolproof and sound framework / model. A critical review of literature on the attempts in this regard reveals that there is no standard framework or model available for such an important activity. This study presents a framework for the quality metric development called Metric Development Framework (qMDF, which is prescriptive in nature. qMDF is a general framework but it has been established specially with ideas of object-oriented metrics. qMDF has been implemented to develop a good quality design metric, as a validation of proposed framework. Finally, it is defended that adaptation of qMDF by metric developers would yield good quality metrics, while ensuring their construct validity, utility, reliability and reduced developmental effort.

  15. QTL Information Table: 505 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qLG-9 Physiological trait Germination/dormancy Seed longevity RFLP C)Interval BIL N...ipponbare Kasalath B G103 R1751 R79 pha Miura, K., Lin, Y., Yano, M., and Nagamine, T. (2002). Mapping quantitative trait

  16. QTL Information Table: 486 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qNSB1-1 Morphological trait Panicle/flower number of secondary branches per panicle...and Xu, C.G. (2002). Genetic analysis of the panicle traits related to yield sink size of rice. Yi Chuan Xue Bao 29, 144-152. ...

  17. QTL Information Table: 788 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qSHT-4 Morphological trait Panicle/flower shattering Mixture C)Interval RIL Pei-Khu... W1944(O. rufipogon Griff.) CDO244 RG214 pha Cai, H.W., and Morishima, H. (2000). Genomic regions affecting seed shatter

  18. QTL Information Table: 1040 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qOE3-1 Physiological trait Eating quality overall evaluation SSR B)Fine F3 SL207 Ko...., and Imbe, T. (2007). QTL Detection for Eating Quality Including Glossiness, Stickiness, Taste and Hardness of Cooked Rice. Breeding Science 57, 231-242. ...

  19. QTL Information Table: 1042 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qTA3 Physiological trait Eating quality taste SSR B)Fine F3 SL207 Koshihikari RM133... (2007). QTL Detection for Eating Quality Including Glossiness, Stickiness, Taste and Hardness of Cooked Rice. Breeding Science 57, 231-242. ...

  20. QTL Information Table: 346 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qGY6-1 Morphological trait Seed Grain yield (t/ha) RFLP C)Interval RIL Zhenshan 97 ...lecular dissection of the genetic relationships of source, sink and transport tissue with yield traits in rice. Theor Appl Genet 106, 649-658. ...

  1. QTL Information Table: 609 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qGY-2b Resistance or Tolerance Drought tolerance grain yield per plant SSR C)Interv..., Li, M.S., Wu, J.H., and Luo, L.J. (2005). Grain yield responses to moisture regimes in a rice population:

  2. QTL Information Table: 787 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available fgr Physiological trait Eating quality flavour or fragrance of basmati and jasmine ...RJ07 pha Bradbury, L.M., Fitzgerald, T.L., Henry, R.J., Jin, Q., and Waters, D.L. (2005). The gene for fragrance in rice. Plant Biotechnol J 3, 363-370. ...

  3. QTL Information Table: 684 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available fon3 mutant from Guguanghuang RM4601 RM1233 pha Jiang, L., Zhang, W., Xia, Z., Jiang, G., Qian, Q., Li, A., ...FON3 Morphological trait Panicle/flower floral organ number SSR C)Interval F2 9311

  4. QTL Information Table: 73 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available GS3 Morphological trait Seed small grain, CAPS A)Physical BC3F2 Minghui 63 Chuan 7 ...hang, Q. (2006). GS3, a major QTL for grain length and weight and minor QTL for grain width and thickness in

  5. QTL Information Table: 288 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Physiological trait Eating quality hot paste viscosity RFLP C)Interval DHL IR64 Azu...cena A RG139 RZ58 pha Bao, J.S., Wu, Y.R., Hu, B., Wu, P., Cui, H.R., and Shu, Q.Y. (2002). QTL for rice grain quality

  6. QTL Information Table: 290 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Physiological trait Eating quality breakdown RFLP C)Interval DHL IR64 Azucena A RZ5...90 RG214 pha Bao, J.S., Wu, Y.R., Hu, B., Wu, P., Cui, H.R., and Shu, Q.Y. (2002). QTL for rice grain quality

  7. QTL Information Table: 289 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Physiological trait Eating quality cool paste viscosity RFLP C)Interval DHL IR64 Az...ucena A RZ574 RZ284 pha Bao, J.S., Wu, Y.R., Hu, B., Wu, P., Cui, H.R., and Shu, Q.Y. (2002). QTL for rice grain quality

  8. QTL Information Table: 754 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Physiological trait Eating quality Pasting temperature (61-02) Mixture C)Interval R...Xu, C.G., and Zhang, Q. (2007). Genetic basis of 17 traits and viscosity parameters characterizing the eating and cooking quality of rice grain. Theor Appl Genet 115, 463-476. ...

  9. QTL Information Table: 989 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Physiological trait Eating quality Chalkiness RFLP C)Interval F2 Zhenshan 97 Minghu...i 63 A C161 R753 pha Tan, Y.F., Xing, Y.Z., Li, J.X., Yu, S.B., Xu, C.G., and Zhang, Q. (2000). Genetic bases of appearance quality

  10. QTL Information Table: 744 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qGT5-1 Physiological trait Eating quality Gelatinization temperature Mixture C)Interval RIL Nanji...ng11 Balilla A RM538 RM480 pha He, Y., Han, Y., Jiang, L., Xu, C., Lu, J., and Xu, M. (2006).

  11. QTL Information Table: 710 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Physiological trait Source activity the grain-setting density(SDEN) SSR C)Interval DHL Zhenshan 97 Wuyuji...ng 2 A RM276 RM121 pha Jiang, G.H., Xu, C.G., Li, X.H., and He, Y.Q. (2004). Character

  12. QTL Information Table: 743 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qGC6-2 Physiological trait Eating quality Gel consistency Mixture C)Interval DHL Nanji...ng11 Balilla A RM508 RM435 pha He, Y., Han, Y., Jiang, L., Xu, C., Lu, J., and Xu, M. (2006). Functional

  13. QTL Information Table: 478 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qRDW5-1 Morphological trait Shoot/Seedling Root dry weight Mixture C)Interval RIL Z...ecular dissection of seedling-vigor and associated physiological traits in rice. Theor Appl Genet 105, 745-753. ...

  14. QTL Information Table: 586 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qSS-2 Physiological trait Sterility spikelet fertility SSR C)Interval F2 CPSLO17 W2...07-2 A RM301 RM263 pha Wang, C., Zhu, C., Zhai, H., and Wan, J. (2005). Mapping segregation distortion loci and quantitative trait

  15. QTL Information Table: 516 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Physiological trait Flowering heading date RFLP C)Interval F2 Taichung 65 Bhadua C1...66 C1121 pha Wang, C.M., Yasui, H., Yoshimura, A., Wan, J.M., and Zhai, H.Q. (2002). Identification of quantitative trait

  16. QTL Information Table: 485 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qNPB6-1 Morphological trait Panicle/flower number of primary branches per panicle M...and Xu, C.G. (2002). Genetic analysis of the panicle traits related to yield sink size of rice. Yi Chuan Xue Bao 29, 144-152. ...

  17. QTL Information Table: 477 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qSDW1-1 Morphological trait Shoot/Seedling Shoot dry weight Mixture C)Interval RIL ...olecular dissection of seedling-vigor and associated physiological traits in rice. Theor Appl Genet 105, 745-753. ...

  18. QTL Information Table: 504 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qSD-5 Physiological trait Germination/dormancy Seed dormancy RFLP C)Interval BIL Ni...pponbare Kasalath A R3166 C249 R1838 pha Miura, K., Lin, Y., Yano, M., and Nagamine, T. (2002). Mapping quantitative trait

  19. QTL Information Table: 872 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qSPN-6 Morphological trait Panicle/flower Spikelets per panicle RFLP C)Interval RIL...n and interaction analysis of six agronomic trait loci of rice based on a recombinant inbred population. Acta Bot Sinica 41, 1199-1203 ...

  20. QTL Information Table: 276 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qFRP-4 Physiological trait Source activity Fertility RFLP C)Interval DHL IR64 Azuce...d Khush, G.S. (2002). Molecular mapping of quantitative trait loci for plant growth, yield and yield related trait

  1. QTL Information Table: 481 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qRS6-1 Morphological trait Shoot/Seedling Reducing sugar content Mixture C)Interval...02). Molecular dissection of seedling-vigor and associated physiological traits in rice. Theor Appl Genet 105, 745-753. ...

  2. QTL Information Table: 400 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qTLL-6 Morphological trait Culm/leaf third leaf length SSR C)Interval RIL Zhenshan .... (2003). QTLs mapping of leaf traits and root vitality in a recombinant inbred line population of rice. Yi Chuan Xue Bao 30, 1133-1139. ...

  3. QTL Information Table: 483 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qSW1-3 Morphological trait Seed Seed weight Mixture C)Interval RIL Zhenshan 97 Ming...ion of seedling-vigor and associated physiological traits in rice. Theor Appl Genet 105, 745-753. ...

  4. QTL Information Table: 484 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qPL3-1 Morphological trait Panicle/flower panicle length Mixture C)Interval RIL Zhe...tic analysis of the panicle traits related to yield sink size of rice. Yi Chuan Xue Bao 29, 144-152. ...

  5. QTL Information Table: 274 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qPEN-4 Morphological trait Panicle/flower Panicle exsertion RFLP C)Interval DHL IR6....P., and Khush, G.S. (2002). Molecular mapping of quantitative trait loci for plant growth, yield and yield related trait

  6. QTL Information Table: 476 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qTDW5-1 Morphological trait Shoot/Seedling Total dry weight Mixture C)Interval RIL ...olecular dissection of seedling-vigor and associated physiological traits in rice. Theor Appl Genet 105, 745-753. ...

  7. QTL Information Table: 489 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qLSVB10-1 Morphological trait Panicle/flower No. of large stem vascular bundles Mix... Xu, C.G. (2002). Genetic analysis of the panicle traits related to yield sink size of rice. Yi Chuan Xue Bao 29, 144-152. ...

  8. QTL Information Table: 519 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available ph1 Morphological trait Dwarf Plant height Mixture C)Interval F3 Zhenshan 97 Minghu...i 63 A RG236 C547 pha Yu, S.B., Li, J.X., Xu, C.G., Tan, Y.F., Li, X.H., and Zhang, Q. (2002). Identification of quantitative trait

  9. Extremely high Q-factor toroidal metamaterials

    CERN Document Server

    Basharin, Alexey A; Volsky, Nikita; Kafesaki, Maria; Economou, Eleftherios N; Ustinov, Alexey V

    2016-01-01

    We demonstrate that, owing to the unique topology of the toroidal dipolar mode, its electric/magnetic field can be spatially confined within subwavelength, externally accessible regions of the metamolecules, which makes the toroidal planar metamaterials a viable platform for high Q-factor resonators due to interfering toroidal and other dipolar modes in metamolecules.

  10. TeensHealth: Q&A

    Science.gov (United States)

    ... Loss Surgery? A Week of Healthy Breakfasts Shyness Q&A Got a question? What do the experts have to say? Look here for answers to many of the questions teens ask us. Girl Stuff Can Bras Affect Breast Growth? Can I Get Sick From Using a ...

  11. QTL Information Table: 891 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available IR24 RM450 RM318 pha Liu, L.L., Yan, X.Y., Jiang, L., Zhang, W.W., Wang, M.Q., Zhou, S.R., Shen, Y., Shen, Y....Y., Liu, S.J., Chen, L.M., Wang, J.K., and Wan, J.M. (2008). Identification of stably expressed quantitativ

  12. QTL Information Table: 892 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available IR24 RM1385 RM3512 pha Liu, L.L., Yan, X.Y., Jiang, L., Zhang, W.W., Wang, M.Q., Zhou, S.R., Shen, Y., Shen,... Y.Y., Liu, S.J., Chen, L.M., Wang, J.K., and Wan, J.M. (2008). Identification of stably expressed quantitat

  13. QTL Information Table: 752 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qGW3 Morphological trait Seed Grain width Mixture C)Interval F2 98SQ1496 Koshihikari B C706 C12534S pha Miyata, M., Yamamoto, T., Komori, T., and Nitta, N. (2007). Marker-assisted selection and evaluation of the QTL for stigma exsertion under japonica rice genetic background. Theor Appl Genet 114, 539-548. ...

  14. QTL Information Table: 741 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qHUS-1-1 Others Others hull siliconcontent SSR C)Interval RIL Zhenshan 97B Milyang ...huang, J.-Y. (2007). Validating a segment on the short arm of chromosome 6 responsible for genetic variation in the hull silicon

  15. Introducing the q-Theil index

    CERN Document Server

    Ausloos, Marcel

    2008-01-01

    Starting from the idea of Tsallis on non-extensive statistical mechanics and the {\\it q-entropy} notion, we recall the Theil index $Th$ and transform it into the $Th_q$ index. Both indices can be used to map onto themselves any time series in a non linear way. We develop an application of the $Th_q$ to the GDP evolution of 20 rich countries in the time interval [1950 - 2003] and search for a proof of globalization of their economies. First we calculate the distances between the "new" time series and to their mean, from which such data simple networks are constructed. We emphasize that it is useful to, and we do, take into account different time "parameters": (i) the moving average time window for the raw time series to calculate the $Th_q$ index; (ii) the moving average time window for calculating the time series distances; (iii) a correlation time lag. This allows us to deduce optimal conditions to measure the features of the network, i.e. the appearance in 1970 of a globalization process in the economy of s...

  16. Q-Method Extended Kalman Filter

    Science.gov (United States)

    Zanetti, Renato; Ainscough, Thomas; Christian, John; Spanos, Pol D.

    2012-01-01

    A new algorithm is proposed that smoothly integrates non-linear estimation of the attitude quaternion using Davenport s q-method and estimation of non-attitude states through an extended Kalman filter. The new method is compared to a similar existing algorithm showing its similarities and differences. The validity of the proposed approach is confirmed through numerical simulations.

  17. Investment Growth Slows in Q1

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    During the first three months of 2011, China’s textile industry maintained stable growth but was exposed to natural disasters, political turmoil in the Middle East and North Africa as well as domestic inflation risk. The following is a review of Chinese textile industry’s investment activities in Q1.

  18. QTL Information Table: 31 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available cal F2 307T (eui/eui) Zhenshan 97 OSJNBa0095J22 M01 M0387 pha Xu, Y.H., Zhu, Y.Y., Zhou, H.C., Li, Q., Sun, Z.X., Liu, Y....ui gene controlling uppermost internode elongation, and construction of a TAC transgene sublibrary. Mol Genet Genomics 272, 149-155. ...

  19. QTL Information Table: 337 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available shan 97 Minghui 63 B RM213 RM208 pha Chen, H., Wang, S., Xing, Y., Xu, C., Hayes, P.M., and Zhang, Q. (2003)...ricularia grisea in rice and barley. PNAS 100, 2544-2549. http://www.pnas.org/cgi/content/abstract/100/5/2544 ...

  20. QTL Information Table: 338 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available shan 97 Minghui 63 B RM213 RM208 pha Chen, H., Wang, S., Xing, Y., Xu, C., Hayes, P.M., and Zhang, Q. (2003)...ricularia grisea in rice and barley. PNAS 100, 2544-2549. http://www.pnas.org/cgi/content/abstract/100/5/2544 ...

  1. QTL Information Table: 340 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available shan 97 Minghui 63 B RM213 RM208 pha Chen, H., Wang, S., Xing, Y., Xu, C., Hayes, P.M., and Zhang, Q. (2003)...ricularia grisea in rice and barley. PNAS 100, 2544-2549. http://www.pnas.org/cgi/content/abstract/100/5/2544 ...

  2. QTL Information Table: 339 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available an 97 Minghui 63 B RM213 RM208 pha Chen, H., Wang, S., Xing, Y., Xu, C., Hayes, P.M., and Zhang, Q. (2003). ...cularia grisea in rice and barley. PNAS 100, 2544-2549. http://www.pnas.org/cgi/content/abstract/100/5/2544 ...

  3. QTL Information Table: 512 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qBLASTa-12-2f Resistance or Tolerance Blast resistance the area under a disdisease ...progress curve RFLP C)Interval RIL Lemont Teqing A RG574 pha Tabien, E., Li, Z., Paterson, H., Marchetti, A., Stan...sel, W., and Pinson, M. (2002). Mapping QTLs for field resistance to the rice blast pathogen and evalu

  4. QTL Information Table: 511 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qBLASTads-2 Resistance or Tolerance Blast resistance Standard Evaluation System (SE...S) for rating leaf blast RFLP C)Interval RIL Lemont Teqing A RG520 pha Tabien, E., Li, Z., Paterson, H., Marchetti, A., Stan...sel, W., and Pinson, M. (2002). Mapping QTLs for field resistance to the rice blast pathogen

  5. QTL Information Table: 319 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qZNT-3 Resistance or Tolerance Other soil stress tolerance Zn2+ toxicity tolerance ... S.H., Terao, H., and Matsuo, M. (2004). Detection of QTLs for zinc toxicity tolerance in rice (Oryza sativa L.). Rice Genetics Newsletter 21, 33-36. ...

  6. QTL Information Table: 986 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available ui 63 A R1245 RM234 pha Tan, Y.F., Sun, M., Xing, Y.Z., Hua, J.P., Sun, X.L., Zhang, Q.F., and Corke, H. (20...Physiological trait Eating quality Protein Mixture C)Interval RIL Zhenshan 97 Mingh

  7. QTL Information Table: 343 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available enshan 97 Minghui 63 B RZ667 RG424 pha Cui, K.H., Peng, S.B., Xing, Y.Z., Yu, S.B., Xu, C.G., and Zhang, Q. (2003). Molecular dissect...ion of the genetic relationships of source, sink and transport tissue with yield traits in rice. Theor Appl Genet 106, 649-658. ...

  8. QTL Information Table: 341 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available section of the genetic relationships of source, sink and transport tissue with yield traits in rice. Theor Appl Genet 106, 649-658. ... ...enshan 97 Minghui 63 B R753 RG352 G359 pha Cui, K.H., Peng, S.B., Xing, Y.Z., Yu, S.B., Xu, C.G., and Zhang, Q. (2003). Molecular dis

  9. QTL Information Table: 342 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available enshan 97 Minghui 63 B RZ667 RG424 pha Cui, K.H., Peng, S.B., Xing, Y.Z., Yu, S.B., Xu, C.G., and Zhang, Q. (2003). Molecular dissect...ion of the genetic relationships of source, sink and transport tissue with yield traits in rice. Theor Appl Genet 106, 649-658. ...

  10. QTL Information Table: 347 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available 97 Minghui 63 B RG393 RZ403 C1087 pha Cui, K.H., Peng, S.B., Xing, Y.Z., Yu, S.B., Xu, C.G., and Zhang, Q. (2003). Molecular dissect...ion of the genetic relationships of source, sink and transport tissue with yield traits in rice. Theor Appl Genet 106, 649-658. ...

  11. Controlling light with high-Q silicon photonic crystal nanocavities: Photon confinement, nonlinearity and coherence

    Science.gov (United States)

    Yang, Xiaodong

    The strong light localization and long photon lifetimes in two-dimensional silicon photonic crystal nanocavities with high quality factor (Q ) and subwavelength modal volume (V) significantly enhance the light-matter interactions, presenting many opportunities to explore new functionalities in silicon nanophotonic integrated circuits for on-chip all-optical information processing, optical computation and optical communications. This thesis will focus on the design, nanofabrication, and experimental characterization of both passive and active silicon nanophotonic devices based on two-dimensional high-Q silicon photonic crystal nanocavities. Three topics of controlling light with these high-Q nanocavities will be presented, including (1) photon confinement mechanism and cavity resonance tuning, (2) enhancement of optical nonlinearities, and (3) all-optical analogue to coherent interferences. The first topic is photon confinement in two-dimensional high- Q silicon photonic crystal nanocavities. In Chapter 2, the role of Q/V as the figure of merit for the enhanced light-matter interaction in optical microcavities and nanocavities is explained and different types of high-Q optical microcavities and nanocavities are reviewed with an emphasis on two-dimensional photonic crystal nanocavities. Then the nanofabrication process and the Q characterization are illustrated for the two-dimensional silicon photonic crystal nanocavities. In Chapter 3, the post-fabrication digital resonance tuning of high-Q silicon photonic crystal nanocavities using atomic layer deposition is proposed and demonstrated, with wide tuning range and precise control of cavity resonances while preserving high quality factors. The second topic is the enhancement of optical nonlinearities in two-dimensional high-Q silicon photonic crystal nanocavities, including stimulated Raman scattering and thermo-optical nonlinearities. In Chapter 4, the enhanced stimulated Raman scattering for low threshold Raman

  12. On the q-type distributions

    Science.gov (United States)

    Nadarajah, Saralees; Kotz, Samuel

    2007-04-01

    Various q-type distributions have appeared in the physics literature in the recent years, see e.g. L.C. Malacarne, R.S. Mendes, E. K. Lenzi, q-exponential distribution in urban agglomeration, Phys. Rev. E 65, (2002) 017106. S.M.D. Queiros, On a possible dynamical scenario leading to a generalised Gamma distribution, in xxx.lanl.gov-physics/0411111. U.M.S. Costa, V.N. Freire, L.C. Malacarne, R.S. Mendes, S. Picoli Jr., E.A. de Vasconcelos, E.F. da Silva Jr., An improved description of the dielectric breakdown in oxides based on a generalized Weibull distribution, Physica A 361, (2006) 215. S. Picoli, Jr., R.S. Mendes, L.C. Malacarne, q-exponential, Weibull, and q-Weibull distributions: an empirical analysis, Physica A 324 (2003) 678-688. A.M.C. de Souza, C. Tsallis, Student's t- and r- distributions: unified derivation from an entropic variational principle, Physica A 236 (1997) 52-57. It is pointed out in the paper that many of these are the same as or particular cases of what has been known in the statistics literature. Several of these statistical distributions are discussed and references provided. We feel that this paper could be of assistance for modeling problems of the type considered by L.C. Malacarne, R.S. Mendes, E. K. Lenzi, q-exponential distribution in urban agglomeration, Phys. Rev. E 65, (2002) 017106. S.M.D. Queiros, On a possible dynamical scenario leading to a generalised Gamma distribution, in xxx.lanl.gov-physics/0411111. U.M.S. Costa, V.N. Freire, L.C. Malacarne, R.S. Mendes, S. Picoli Jr., E.A. de Vasconcelos, E.F. da Silva Jr., An improved description of the dielectric breakdown in oxides based on a generalized Weibull distribution, Physica A 361, (2006) 215. S. Picoli, Jr., R.S. Mendes, L.C. Malacarne, q-exponential, Weibull, and q-Weibull distributions: an empirical analysis, Physica A 324 (2003) 678-688. A.M.C. de Souza, C. Tsallis, Student's t- and r- distributions: unified derivation from an entropic variational principle, Physica A 236

  13. q-Difference Realization of $U_q(sl(M|N))$ and Its Application to Free Boson Realization of $U_q(\\widehat{sl}(2|1))$

    CERN Document Server

    Awata, H; Shiraishi, J

    1997-01-01

    We present a q-difference realization of the quantum superalgebra U_q(sl(M|N)), which includes Grassmann even and odd coordinates and their derivatives. Based on this result we obtain a free boson realization of the quantum affine superalgebra U_q(\\widehat{sl}(2|1)) of an arbitrary level k.

  14. The $q$-WakimotoO Realization of the Superalgebras $U_q(\\widehat{sl}(N|1))$ AND $U_{q,p}(\\widehat{{sl}}(N|1))$

    CERN Document Server

    Kojima, Takeo

    2012-01-01

    We give bosonizations of the superalgebras $U_q(\\widehat{sl}(N|1))$ and $U_{q,p}(\\widehat{sl}(N|1))$ for an arbitrary level $k \\in {\\bf C}$. We introduce the submodule by the $\\xi$-$\\eta$ system, that we call the $q$-Wakimoto realization.

  15. Chronic Q fever in the Netherlands 5 years after the start of the Q fever epidemic: results from the Dutch chronic Q fever database

    NARCIS (Netherlands)

    Kampschreur, L.M.; Delsing, C.E.; Groenwold, R.H.; Wegdam-Blans, M.C.; Bleeker-Rovers, C.P.; Jager-Leclercq, M.G. De; Hoepelman, A.I.; Kasteren, M.E.E. van; Buijs, J.; Renders, N.H.; Nabuurs-Franssen, M.H.; Oosterheert, J.J.; Wever, P.C.

    2014-01-01

    Coxiella burnetii causes Q fever, a zoonosis, which has acute and chronic manifestations. From 2007 to 2010, the Netherlands experienced a large Q fever outbreak, which has offered a unique opportunity to analyze chronic Q fever cases. In an observational cohort study, baseline characteristics and

  16. Q-Sort Technique and Q-Methodology—Innovative Methods for Examining Attitudes and Opinions

    Directory of Open Access Journals (Sweden)

    Florian H. Müller

    2004-05-01

    Full Text Available In the German tradition of social sciences Q-method is not well known. Q-method combines both qualitative and quantitative research and is used to examine complex subjective structures like opinions, attitudes and values. This paper presents an introduction to Q-technique and its underlying methodology. The various applications of the method for a qualitative orientated research in the fields of market, opinion and media are also listed. The significance of the method for single case studies, for exploratory cluster analysis and for a combined application of qualitative and quantitative research strategies is emphasized. URN: urn:nbn:de:0114-fqs0402347

  17. Tetrasomy 15q11-q13 Diagnosed by FISH in a Patient with Autistic Disorder

    Directory of Open Access Journals (Sweden)

    Karim Ouldim

    2007-01-01

    Full Text Available We report the case of a Moroccan boy with mental retardation, hyperactivity, epilepsy, developmental problems and behavioural disorders. Cytogenetic analysis showed the presence of a supernumerary marker chromosome. Molecular cytogenetics allowed us to determine the marker as an inverted duplication of chromosome 15. It is the first case of a Moroccan patient with tetrasomy 15q in which fluorescence in situ hybridization (FISH enabled us to specify the diagnosis. Interestingly, this patient has an infantile autism with cytogenetic abnormalities on chromosomal region 15q11-q13 as reported in patients with Autistic Disorder.

  18. Substantial reduction of the gastric carcinoma critical region at 6q16.3-q23.1

    NARCIS (Netherlands)

    Carvalho, B; Seruca, R; Carneiro, F; Buys, CHCM; Kok, K

    Deletions of the long arm of chromosome 6 are a common event in gastric carcinomas. In a previous study, deletion mapping of 6q identified two smallest regions of overlap (SROs) of heterozygous deletions: one interstitial, spanning 12-16 cM, bordered by D6S268 (6q16.3-q21) and ARGI (6q22.3-q23.1),

  19. Substantial reduction of the gastric carcinoma critical region at 6q16.3-q23.1

    NARCIS (Netherlands)

    Carvalho, B; Seruca, R; Carneiro, F; Buys, CHCM; Kok, K

    1999-01-01

    Deletions of the long arm of chromosome 6 are a common event in gastric carcinomas. In a previous study, deletion mapping of 6q identified two smallest regions of overlap (SROs) of heterozygous deletions: one interstitial, spanning 12-16 cM, bordered by D6S268 (6q16.3-q21) and ARGI (6q22.3-q23.1), a

  20. Coenzyme Q10 therapy in current clinical practice

    Directory of Open Access Journals (Sweden)

    Abhishek Soni

    2015-04-01

    Full Text Available Coenzyme Q10 (CoQ10 is a naturally occurring, lipid soluble, essential compound and is also known as ubiquinone. CoQ10 acts as an intermediate of the electron transport chain situated in membrane of mitochondria and vital for ATP production and cellular respiration. CoQ10 also serves as an intercellular antioxidant. All the clinical use of CoQ10 are based upon these two functions. CoQ10 levels are altered in a number of oncological as well as non-oncological diseases. Furthermore, recent data indicate that CoQ10 has an impact on the expression of many genes involved in metabolism, cellular transport, transcription control, and cell signaling, making CoQ10 a potent gene regulator. CoQ10 supplementation is useful in diseases associated with CoQ10 deficiency which includes primary and secondary CoQ10 deficiencies, fibromyalgia, diabetes mellitus, mitochondrial diseases, neurodegenerative diseases, cardiovascular disease, cancer, male infertility and periodontal disease. Clinical presentations of severe CoQ10 deficiency include severe infantile multisystemic disease, encephalomyopathy, isolated myopathy cerebellar ataxia and Leigh syndrome with growth retardation. Oral CoQ10 administration can correct CoQ10 deficiency since it increases CoQ10 tissue levels. CoQ10 therapy has no serious side effects in humans and new formulations have been developed that increase CoQ10 absorption and tissue distribution. Future trends involving CoQ10 in many diseases needs more clinical trials for better understanding of CoQ10 efficacy. [Int J Res Med Sci 2015; 3(4.000: 817-825

  1. 新型Q-P-T和传统Q-T工艺对不同C含量马氏体钢组织和力学性能的影响%EFFECTS OF NOVEL Q-P-T AND TRADITIONAL Q-T PROCESSES ON THE MICROSTRUCTURE AND MECHANICAL PROPERTIES OF MARTENSITIC STEELS WITH DIFFERENT CARBON CONTENT

    Institute of Scientific and Technical Information of China (English)

    张柯; 许为宗; 郭正洪; 戎咏华; 王毛球; 董瀚

    2011-01-01

    Compared with traditional quenching and tempering (Q-T) treatment, the product of strength and elongation of the carbon steel can be enhanced significantly by novel quenchingpartitioning-tempering (Q-P-T) treatment, especially for the medium carbon steel.Based on the tensile results, the product of strength and elongation of the Fe-0.42C-1.46Mn-1.58Si-0.028Nb specimen treated by Q-P-T, is up to 31627 MPa.% with elongation 20.3%, which not only is higher than the specimen treated by Q-T process, but also meets the mechanical properties predicted of next generation advanced high strength steel.Microstructural analysis indicates the differences in Q-T and Q-P-T process lie on the amount of retained austenite and its size distribution as well as the size range of lath martensite.The former results in the low amount (<3%) of thin film-like austenite in addition to nonuniform martensite size, while the later results in the high amount of thick flake-like austenite accompanying uniform martensite size.Therefore, the higher barrier for micro-crack propagation and the better plastic deformation ability of advanced high strength steel (AHSS) can be obtained by Q-P-T treatment.%对比新型淬火-分配-回火(Q-P-T)和传统淬火-回火(Q-T)处理对中、低碳钢力学性能的影响发现,在提高材料的强塑积方面Q-P-T处理远胜于Q-T处理,特别是对中碳钢的效果更为显著.在所研究的试样中,Fe-0.42C-1.46Mn-1.58Si-0.028Nb合金的强塑积经Q-P-T处理后高达31627 MPa·%,且延伸率达20.3%,不仅远高于传统Q-T处理的试样,而且已满足新一代先进高强度钢预测的性能.显微组织分析表明,Q-T和Q-P-T处理的差异在于残留奥氏体的量和尺寸分布以及马氏体板条的均匀程度.前者含少量(<3%)较薄的"薄膜状"残留奥氏体,且马氏体板条尺寸范围较宽;而后者含较多较厚的"薄片状"残留奥氏体,且马氏体板条尺寸分布较窄.因此Q-P-T处理的先进高强度

  2. Using UHPLC Q-Trap/MS as a complementary technique to in-depth mine UPLC Q-TOF/MS data for identifying modified nucleosides in urine.

    Science.gov (United States)

    Lu, Zhiwei; Wang, Qing; Wang, Meiling; Fu, Shuang; Zhang, Qingqing; Zhang, Zhixin; Zhao, Huizhen; Liu, Yuehong; Huang, Zhenhai; Xie, Ziye; Yu, Honghong; Gao, Xiaoyan

    2017-03-12

    Modified nucleosides, metabolites of RNA, are potential biomarkers of cancer before the appearance of morphological abnormalities. It is of great significance to comprehensively detect and identify nucleosides in human urine for discovery of cancer biomarkers. However, the lower abundance, the greater polarity and the matrix effects make it difficult to detect urinary nucleosides. In this paper, an integrated method consisted of sample preparation followed by ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC Q-TOF/MS) detection and primary identification, then ultra-high performance liquid chromatography coupled with hybrid triple quadrupole linear ion trap mass spectrometer (UHPLC Q-Trap/MS) further identification and validation were introduced. Firstly, to enrich the nucleosides and eliminate the urine matrix effects, different sorbent materials of solid phase extraction (SPE) and the elution conditions were screened. Secondly, UPLC Q-TOF/MS was used to acquire mass data in MS(E) mode. The structural formulas of nucleosides in urine sample were primarily identified according to retention time, accurate mass precursor ions and fragment ions from in-house database and online database. Thirdly, the preliminary identified nucleoside structures lacking of characteristic fragment ions were verified by UHPLC Q-Trap/MS in multiple reaction monitoring trigger enhanced product ion scan (MRM-EPI) and neutral loss scan (NL). At last, phenylboronic acid (PBA)-based SPE was utilized due to its higher MS signal and weaker matrix effects under optimized extraction conditions. Fifty-five nucleosides were primarily identified by UPLC Q-TOF/MS, among which 50 nucleosides were confirmed by UHPLC Q-Trap/MS. Five nucleosides, namely 4',5'-didehydro-5'-deoxyadenosine, 4',5'-didehydro-5'-deoxyinosine, isonicotinamide riboside, peroxywybutosine and hydroxywybutosine, were found from urine for the first time. The results will expand the Human

  3. Studies of TBX4 and chromosome 17q23.1q23.2: an uncommon cause of nonsyndromic clubfoot

    Science.gov (United States)

    Lu, W.; Bacino, C. A.; Richards, B.S.; Alvarez, C.; VanderMeer, J.E.; Vella, M.; Ahituv, N.; Sikka, N.; Dietz, F.R.; Blanton, S.H.; Hecht, J.T.

    2012-01-01

    Clubfoot is a common birth defect characterized by inward posturing and rigid downward displacement of one or both feet. The etiology of syndromic forms of clubfoot is varied and the causes of isolated clubfoot are not well understood. A microduplication of 2.2 Mb on chromosome 17q23.1q23.2 which includes T-box 4 (TBX4), a hindlimb-specific gene, and 16 other genes was recently identified in 3 of 66 families reported as nonsyndromic clubfoot, but additional non-foot malformations place them in the syndromic clubfoot category. Our study assesses whether variation in or around TBX4 contributes to nonsyndromic clubfoot. To determine whether this microduplication was a common cause of nonsyndromic clubfoot, 605 probands (from 148 multiplex and 457 simplex families) with nonsyndromic clubfoot were evaluated by copy number and oligonucleotide array CGH testing modalities. Only one multiplex family (0.68%) that had 16 with clubfoot and 9 with other foot anomalies, had a 350kb microduplication, which included the complete duplication of TBX4 and NACA2 and partial duplication of BRIP1. The microduplication was transmitted in an autosomal dominant pattern and all with the microduplication had a range of phenotypes from short wide feet and toes to bilateral clubfoot. Minimal evidence was found for an association between TBX4 and clubfoot and no pathogenic sequence variants were identified in the two known TBX4 hindlimb enhancer elements. Altogether, these results demonstrate that variation in and around the TBX4 gene and the 17q23.1q23.2 microduplication are not a frequent cause of this common orthopedic birth defect and narrows the 17q23.1q23.2 nonsyndromic clubfoot-associated region. PMID:22678995

  4. COARSE-MESH-ACCURACY IMPROVEMENT OF BILINEAR Q4-PLANE ELEMENT BY THE COMBINED HYBRID FINITE ELEMENT METHOD

    Institute of Scientific and Technical Information of China (English)

    谢小平; 周天孝

    2003-01-01

    The combined hybrid finite element method is of an intrinsic mechanism of enhancing coarse-mesh-accuracy of lower order displacement schemes. It was confirmed that the combined hybrid scheme without energy error leads to enhancement of accuracy at coarse meshes, and that the combination parameter plays an important role in the enhancement. As an improvement of conforming bilinear Q4-plane element, the combined hybrid method adopted the most convenient quadrilateral displacements-stress mode, i. e.,the mode of compatible isoparametric bilinear displacements and pure constant stresses. By adjusting the combined parameter, the optimized version of the combined hybrid element was obtained and numerical tests indicated that this parameter-adjusted version behaves much better than Q4-element and is of high accuracy at coarse meshes. Due to elimination of stress parameters at the elemental level, this combined hybrid version is of the same computational cost as that of Q4 -element.

  5. Design and Fabrication of the Suspended High-Q Spiral Inductors with X-Beams

    CERN Document Server

    Hsieh, M C; Fang, Y K; Lin, C S

    2008-01-01

    In this paper, deep sub-micron CMOS process compatible high Q on chip spiral inductors with air gap structure were designed and fabricated. In the design the electromagnetic were used for electrical-characteristics and maximum mechanical strength, respectively. The copper wires were capped with electroless Ni plating to prevent the copper from oxidizing. A Si3N4/ SiO2 X-beam was designed to increase the mechanical strength of the inductor in air gap. The enhancement of maximum mechanical strength of a spiral inductor with X-beams is more than 4500 times. Among these structures, the measured maximum quality factor (Q) of the suspending inductor and frequency at maximum Q are improved from 5.2 and 1.6GHz of conventional spiral inductor to 7.3 and 2.1 GHz, respectively.

  6. Damping mechanisms in high-Q micro and nanomechanical string resonators

    DEFF Research Database (Denmark)

    Schmid, Silvan; Jensen, K. D.; Nielsen, K. H.

    2011-01-01

    been concluded that Q is enhanced due to the high energy stored in the string tension. In this paper, damping mechanisms in string resonators are systematically investigated by varying the geometry and the tensile stress of silicon nitride microstrings. The measured quality factors are compared......Resonant micro and nanostrings were found to have extraordinarily high quality factors (Qs). Since the discovery of the high Qs of silicon nitride nanostrings, the understanding of the underlying mechanisms allowing such high quality factors has been a topic of several investigations. So far it has...... to an analytical model for Q based on bending-related damping mechanisms. It is shown that internal material damping is limiting the quality factor of narrow strings with a width of 3 μm. Q is strongly width dependent and clamping losses evidently seem to be the limiting damping mechanism for wider strings...

  7. Novel ultrasound detector based on small slot micro-ring resonator with ultrahigh Q factor

    Science.gov (United States)

    Zhang, Senlin; Chen, Jian; He, Sailing

    2017-01-01

    An ultrasound detector based on a novel slot micro-ring resonator (SMRR) with ultrahigh Q factor and small size is proposed in this study. The theoretical Q factor of SMRR can be approximately 8.34×108 with bending radius of merely 12 μm. The ultrahigh Q factor leads to an enhanced sensitivity that is approximately two orders of that of state-of-the-art ultrasound detector based on polymer micro-ring resonator. Moreover, the 3 dB bandwidth of the ultrasound detector is approximately 540 MHz, thereby leading to an ultrahigh axial resolution of 1.2 μm. The proposed detector is also CMOS compatible and can be easily and extensively integrated to be maximized in photoacoustic microscopy.

  8. Blood CoQ10 levels and safety profile after single-dose or chronic administration of PureSorb-Q40: animal and human studies.

    Science.gov (United States)

    Nukui, Kazuki; Yamagishi, Toshihiko; Miyawaki, Hiromi; Kettawan, Aikkarach; Okamoto, Tadashi; Belardinelli, Romualdo; Tiano, Luca; Littarru, Gian Paulo; Sato, Kiyoshi

    2008-01-01

    Coenzyme Q10 (CoQ10) is known to be highly hydrophobic and, as such, insoluble in water: this leads to serious inconvenience when trying to incorporate it in food products. Its absorption is also known to be very limited. PureSorb-Q40 (P40) (Water-soluble type CoQ10 powder, CoQ10 content 40 w/w % was developed in order to improve its use with food products and to enhance its absorption. In the present study the absorption of this novel formulation was compared to a conventional lipid soluble CoQ10 by administering both products to rats and humans. Acute, single-administration studies in rats showed that P40 has a higher absorption, compared to lipid soluble CoQ10, both in prandial and fasting states. Similarly, single administration in humans revealed a higher absorption level for P40, taken in the fasting state or together with meals. In the rat study, no adverse effects were observed with P40 at doses up to 2,000 mg/kg in both sexes. In a double-blind, placebo controlled, comparative study conducted on 46 healthy volunteers and randomly divided into two groups, in the group receiving 900~mg of CoQ10 per day, for 4 consecutive weeks, the average level at two weeks was 8.79 +/- 3.34 microg/mL, similar to the corresponding level after 4 weeks (8.33 +/- 4.04 microg/mL). After 2 weeks of washout, serum CoQ10 level decreased to 1.30 +/- 0.49 microg/mL. P40 intake did not cause any significant changes in symptoms and clinical laboratory tests as assessed by physical, hematological, blood biochemical or urinalysis. Clinical examinations also did not reveal any abnormalities. The above blood (serum) CoQ10 level at 2 weeks after start of intake was compared with other reported values. The same dose of CoQ10 (900mg/day), when administered by softgel capsules yielded a plasma CoQ10 concentration of 3.6 microg/mL, while P40 levels were 8.79 +/- 3.34 microg/mL. These levels are remarkably high for instance when compared to the corresponding levels obtained, in patients

  9. Ordered-subset analysis of savant skills in autism for 15q11-q13.

    Science.gov (United States)

    Ma, D Q; Jaworski, J; Menold, M M; Donnelly, S; Abramson, R K; Wright, H H; Delong, G R; Gilbert, J R; Pericak-Vance, M A; Cuccaro, Michael L

    2005-05-05

    Autism is a complex disorder characterized by genetic and phenotypic heterogeneity. Analysis of phenotypically homogeneous subtypes has been used to both confirm and narrow potential autism linkage regions such as the chromosomal region 15q11-q13. Increased evidence for linkage in this region had been found in a subgroup of 21 autism families (total families = 94) stratified based on a savant skill factor (SSF) from the Autism Diagnostic Interview, Revised (ADI-R). We examined the savant phenotypic finding in our sample of 91 multiplex autism families. Using two-point parametric analysis in stratification with a cutoff point of a savant skill score of 0.16, our families failed to demonstrate linkage to 15q11-q13. In addition, ordered subset analysis (OSA) using SSF as a covariate also failed to show evidence for linkage. Our findings do not support savant skills as an informative phenotypic subset for linkage in our sample.

  10. Comparative genomic hybridization analysis detects frequent over-representation of DNA sequences at 3q, 7p, 8q and 18q in head and neck carcinomas

    DEFF Research Database (Denmark)

    Bergamo, N A; Rogatto, S R; Poli-Frederico, R C;

    2000-01-01

    Comparative genomic hybridization (CGH) was used to identify chromosomal imbalances in 19 samples of squamous cell carcinoma of the head and neck (HNSCC). The chromosome arms most often over-represented were 3q (48%), 8q (42%), and 7p (32%); in many cases, these changes were observed at high copy...... and 2q material were detected in patients exhibiting a clinical history of recurrence and/or metastasis followed by terminal disease. This association suggests that gain of 1q and 2q may be a new marker of head and neck tumors with a refractory clinical response....

  11. Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells.

    Directory of Open Access Journals (Sweden)

    Qunying Hong

    Full Text Available BACKGROUND: Tissue exudates contain low levels of serum complement proteins, and their regulatory effects on prostate cancer progression are largely unknown. We examined specific serum complement components in coordinating the activation of tumor suppressors p53 and WWOX (also named FOR or WOX1 and kinases ERK, JNK1 and STAT3 in human prostate DU145 cells. METHODOLOGY/PRINCIPAL FINDINGS: DU145 cells were cultured overnight in 1% normal human serum, or in human serum depleted of an indicated complement protein. Under complement C1q- or C6-free conditions, WOX1 and ERK were mainly present in the cytoplasm without phosphorylation, whereas phosphorylated JNK1 was greatly accumulated in the nuclei. Exogenous C1q rapidly restored the WOX1 activation (with Tyr33 phosphorylation in less than 2 hr. Without serum complement C9, p53 became activated, and hyaluronan (HA reversed the effect. Under C6-free conditions, HA induced activation of STAT3, an enhancer of metastasis. Notably, exogenous C1q significantly induced apoptosis of WOX1-overexpressing DU145 cells, but not vehicle-expressing cells. A dominant negative and Y33R mutant of WOX1 blocked the apoptotic effect. C1q did not enhance p53-mediated apoptosis. By total internal reflection fluorescence (TIRF microscopy, it was determined that C1q destabilized adherence of WOX1-expressing DU145 cells by partial detaching and inducing formation of clustered microvilli for focal adhesion particularly in between cells. These cells then underwent shrinkage, membrane blebbing and death. Remarkably, as determined by immunostaining, benign prostatic hyperplasia and prostate cancer were shown to have a significantly reduced expression of tissue C1q, compared to age-matched normal prostate tissues. CONCLUSIONS/SIGNIFICANCE: We conclude that complement C1q may induce apoptosis of prostate cancer cells by activating WOX1 and destabilizing cell adhesion. Downregulation of C1q enhances prostate hyperplasia and cancerous

  12. Deletion 22q13.3 syndrome

    Directory of Open Access Journals (Sweden)

    Phelan Mary C

    2008-05-01

    Full Text Available Abstract The deletion 22q13.3 syndrome (deletion 22q13 syndrome or Phelan-McDermid syndrome is a chromosome microdeletion syndrome characterized by neonatal hypotonia, global developmental delay, normal to accelerated growth, absent to severely delayed speech, and minor dysmorphic features. The deletion occurs with equal frequency in males and females and has been reported in mosaic and non-mosaic forms. Due to lack of clinical recognition and often insufficient laboratory testing, the syndrome is under-diagnosed and its true incidence remains unknown. Common physical traits include long eye lashes, large or unusual ears, relatively large hands, dysplastic toenails, full brow, dolicocephaly, full cheeks, bulbous nose, and pointed chin. Behavior is autistic-like with decreased perception of pain and habitual chewing or mouthing. The loss of 22q13.3 can result from simple deletion, translocation, ring chromosome formation and less common structural changes affecting the long arm of chromosome 22, specifically the region containing the SHANK3 gene. The diagnosis of deletion 22q13 syndrome should be considered in all cases of hypotonia of unknown etiology and in individuals with absent speech. Although the deletion can sometimes be detected by high resolution chromosome analysis, fluorescence in situ hybridization (FISH or array comparative genomic hybridization (CGH is recommended for confirmation. Differential diagnosis includes syndromes associated with hypotonia, developmental delay, speech delay and/or autistic-like affect (Prader-Willi, Angelman, Williams, Smith-Magenis, Fragile X, Sotos, FG, trichorhinophalangeal and velocardiofacial syndromes, autism spectrum disorders, cerebral palsy. Genetic counseling is recommended and parental laboratory studies should be considered to identify cryptic rearrangements and detect parental mosaicism. Prenatal diagnosis should be offered for future pregnancies in those families with inherited rearrangements

  13. Genetic bases and clinical manifestations of coenzyme Q10 (CoQ 10) deficiency.

    Science.gov (United States)

    Desbats, Maria Andrea; Lunardi, Giada; Doimo, Mara; Trevisson, Eva; Salviati, Leonardo

    2015-01-01

    Coenzyme Q(10) is a remarkable lipid involved in many cellular processes such as energy production through the mitochondrial respiratory chain (RC), beta-oxidation of fatty acids, and pyrimidine biosynthesis, but it is also one of the main cellular antioxidants. Its biosynthesis is still incompletely characterized and requires at least 15 genes. Mutations in eight of them (PDSS1, PDSS2, COQ2, COQ4, COQ6, ADCK3, ADCK4, and COQ9) cause primary CoQ(10) deficiency, a heterogeneous group of disorders with variable age of onset (from birth to the seventh decade) and associated clinical phenotypes, ranging from a fatal multisystem disease to isolated steroid resistant nephrotic syndrome (SRNS) or isolated central nervous system disease. The pathogenesis is complex and related to the different functions of CoQ(10). It involves defective ATP production and oxidative stress, but also an impairment of pyrimidine biosynthesis and increased apoptosis. CoQ(10) deficiency can also be observed in patients with defects unrelated to CoQ(10) biosynthesis, such as RC defects, multiple acyl-CoA dehydrogenase deficiency, and ataxia and oculomotor apraxia.Patients with both primary and secondary deficiencies benefit from high-dose oral supplementation with CoQ(10). In primary forms treatment can stop the progression of both SRNS and encephalopathy, hence the critical importance of a prompt diagnosis. Treatment may be beneficial also for secondary forms, although with less striking results.In this review we will focus on CoQ(10) biosynthesis in humans, on the genetic defects and the specific clinical phenotypes associated with CoQ(10) deficiency, and on the diagnostic strategies for these conditions.

  14. A high-order q-difference equation for q-Hahn multiple orthogonal polynomials

    DEFF Research Database (Denmark)

    Arvesú, J.; Esposito, Chiara

    2012-01-01

    A high-order linear q-difference equation with polynomial coefficients having q-Hahn multiple orthogonal polynomials as eigenfunctions is given. The order of the equation coincides with the number of orthogonality conditions that these polynomials satisfy. Some limiting situations when are studie....... Indeed, the difference equation for Hahn multiple orthogonal polynomials given in Lee [J. Approx. Theory (2007), ), doi: 10.1016/j.jat.2007.06.002] is obtained as a limiting case....

  15. On sums of q-independent SU[sub q](2) quantum variables

    Energy Technology Data Exchange (ETDEWEB)

    Lenczewski, R. (Politechnika Wroclawska, Wroclaw (Poland). Hugo Steinhaus Center for Stochastic Methods)

    1993-05-01

    A representation-free approach to the q-analog of the quantum central limit theorem for C=SU[sub 1](2) is presented. It is shown that for certain functions [phi][epsilon]-C* one can derive a version of a quantum central limit theorem (qclt) with [radical][N] as a scaling parameter, which may be viewed as a q-analog of qclt. (orig.).

  16. Segmental maternal uniparental disomy 7q associated with DLK1/GTL2 (14q32) hypomethylation.

    Science.gov (United States)

    Begemann, Matthias; Spengler, Sabrina; Kordass, Ulrike; Schröder, Carmen; Eggermann, Thomas

    2012-02-01

    Aberrant methylation at different imprinted loci has been reported for several congenital imprinting disorders, that is, Silver-Russell syndrome (SRS), but the coincidental occurrence of aberrant methylation and uniparental disomy (UPD) has not yet been described. We report on a patient initially diagnosed with SRS carrying a segmental maternal UPD of chromosome 7 [upd(7q)mat]. By further screening the patient's DNA for methylation defects on other chromosomes we identified a hypomethylation of the paternally methylated DLK1/GTL2 locus in 14q32, an epigenotype typically associated with the upd(14)mat phenotype. Detailed clinical analysis confirmed the molecular finding in the patient indicating that the 14q32 epimutation was clinically preponderant. The parallel occurrence of upd(7q)mat and a DLK1/GTL2 hypomethylation in the same patient is a unique finding. Indeed, both disturbances might have occurred coincidentally, but it can also be hypothesized that the upd(7q)mat as the initial genomic mutation represents a trans-acting mutation causing an aberrant methylation in 14q32.

  17. Photons with half-integral spin as q-Fermions

    CERN Document Server

    Parthasarathy, R

    2016-01-01

    The recently discovered 'light (photons) with half-integral spin' is interpreted as q-Fermions proposed by us in 1991, as these q-Fermions satisfy q-deformed anti-commutation relations (pertaining to spin half) and have the property that more than one q-Fermion can occupy a given quantum state. In this article, in view of the recent discovery, we recall the construction of q-Fermions and give the statistical properties of q-Fermion gas, based on our preprint in 1992.

  18. Multiple blocking sets in PG(n,q), n>=3

    DEFF Research Database (Denmark)

    Barat, Janos

    2004-01-01

    This article discusses minimal s-fold blocking sets B in PG (n, q), q = ph, p prime, q > 661, n > 3, of size |B| > sq + cp q2/3 - (s - 1) (s - 2)/2 (s > min (cp q1/6, q1/4/2)). It is shown that these s-fold blocking sets contain the disjoint union of a collection of s lines and/or Baer subplanes...... of Hamada and Helleseth on codes meeting the Griesmer bound....

  19. On q-power cycles in cubic graphs

    DEFF Research Database (Denmark)

    Bensmail, Julien

    2017-01-01

    In the context of a conjecture of Erdos and Gyárfás, we consider, for any q ≥ 2, the existence of q-power cycles (i.e. with length a power of q) in cubic graphs. We exhibit constructions showing that, for every q ≥ 3, there exist arbitrarily large cubic graphs with no q-power cycles. Concerning...... the remaining case q = 2 (which corresponds to the conjecture of Erdos and Gyárfás), we show that there exist arbitrarily large cubic graphs whose only 2-power cycles have length 4 only, or 8 only....

  20. On q-power cycles in cubic graphs

    DEFF Research Database (Denmark)

    Bensmail, Julien

    2016-01-01

    In the context of a conjecture of Erdos and Gyárfás, we consider, for any q ≥ 2, the existence of q-power cycles (i.e. with length a power of q) in cubic graphs. We exhibit constructions showing that, for every q ≥ 3, there exist arbitrarily large cubic graphs with no q-power cycles. Concerning...... the remaining case q = 2 (which corresponds to the conjecture of Erdos and Gyárfás), we show that there exist arbitrarily large cubic graphs whose only 2-power cycles have length 4 only, or 8 only....

  1. High Q^2 Measurements from HERA

    CERN Document Server

    South, David M

    2010-01-01

    New measurements of neutral and charged current cross sections at large negative four-momentum transfer squared Q^2 have been performed by H1 and ZEUS, using up to the complete HERA II ep data, which was taken with polarised electron and positron beams. The data are compared to predictions of the Standard Model, based on various parton distribution function parameterisations. The polarisation asymmetry of the neutral current interaction is measured as a function of Q^2, as well as the polarisation dependence of the charged current cross section and both are found to be in agreement with the Standard Model expectation. The HERA II cross sections are also combined with previously published HERA I data to obtain the most precise unpolarised measurements.

  2. Defect (p,q) Five-branes

    CERN Document Server

    Kimura, Tetsuji

    2015-01-01

    We study the local description of composite five-branes of codimension two. The formulation is constructed by virtue of the $SL(2,{\\mathbb Z}) \\times SL(2,{\\mathbb Z)}$ monodromy associated with two-torus. Applying the conjugate monodromy transformations to the complex structures of the two-torus, we obtain the field configuration of the defect $(p,q)$ five-branes. This is the composite state of $p$ defect NS5-branes and $q$ exotic $5^2_2$-branes. We also obtain a new hyper-K\\"{a}hler geometry. This is an ALG space, a generalization of an ALF space which asymptotically has a tri-holomorphic two-torus action. This geometry appears in the conjugate configuration of the single defect KK5-brane.

  3. Weyl modules and q-Whittaker functions

    CERN Document Server

    Braverman, Alexander

    2012-01-01

    Let G be a semi-simple simply connected group over complex numbers. In this paper we give a geometric definition of the (dual) Weyl modules over the group G[t] and show that their characters form an eigen-function of the lattice version of the q-Toda integrable integrable system (defined by means of the quantum group version of Kostant-Whittaker reduction due to Etingof and Sevostyanov). All the proofs are algebro-geometric and rely on our previous work which interprets the universal eigen-function of the q-Toda system in terms of rings of functions on the spaces of based quasi-maps from P^1 to the flag variety of G. We discuss in detail the relation between the current work and the works of Cherednik, Ion and Gerasimov-Lebedev-Oblezin.

  4. Complement protein C1q-mediated neuroprotection is correlated with regulation of neuronal gene and microRNA expression.

    Science.gov (United States)

    Benoit, Marie E; Tenner, Andrea J

    2011-03-02

    Activation of the complement cascade, a powerful effector mechanism of the innate immune system, is associated with neuroinflammation but also with elimination of inappropriate synapses during development. Synthesis of C1q, a recognition component of the complement system, occurs in brain during ischemia/reperfusion and Alzheimer's disease, suggesting that C1q may be a response to injury. In vitro, C1q, in the absence of other complement proteins, improves neuronal viability and neurite outgrowth and prevents β-amyloid-induced neuronal death, suggesting that C1q may have a direct neuroprotective role. Here, investigating the molecular basis for this neuroprotection in vitro, addition of C1q to rat primary cortical neurons significantly upregulated expression of genes associated with cholesterol metabolism, such as cholesterol-25-hydroxylase and insulin induced gene 2, and transiently decreased cholesterol levels in neurons, known to facilitate neurite outgrowth. In addition, the expression of syntaxin-3 and its functional association with synaptosomal-associated protein 25 was increased. C1q also increased the nuclear translocation of cAMP response element-binding protein and CCAAT/enhancer-binding protein-δ (C/EBP-δ), two transcription factors involved in nerve growth factor (NGF) expression and downregulated specific microRNAs, including let-7c that is predicted to target (and thus inhibit) NGF and neurotrophin-3 (NT-3) mRNA. Accordingly, C1q increased expression of NGF and NT-3, and small interfering RNA inhibition of C/EBP-δ, NGF, or NT-3 expression prevented the C1q-dependent neurite outgrowth. No such neuroprotective effect is seen in the presence of C3a or C5a. Finally, the induced neuronal gene expression required conformationally intact C1q. These results show that C1q can directly promote neuronal survival, thereby demonstrating new interactions between immune proteins and neuronal cells that may facilitate neuroprotection.

  5. QTL Information Table: 1021 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available flag and second leaves Mixture C)Interval RIL SNU-SG1 Milyang 23 B RM440 RM430 pha Yoo, S.C., Cho, S.H., Zhang, H., Paik, H.C., Lee,... C.H., Li, J., Yoo, J.H., Lee, B.W., Koh, H.J., Seo, H.S., and Paek, N.C. (2007). Q

  6. QTL Information Table: 198 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available G249 RG418 pha Luo, L.J., Li, Z.K., Mei, H.W., Shu, Q.Y., Tabien, R., Zhong, D.B., Ying, C.S., Stansel, J.W....eeding Depression and Heterosis in Rice. II. Grain Yield Components. Genetics 158, 1755-1771. http://www.genetics.org/cgi/content/abstract/158/4/1755 ...

  7. p-q growth via relaxation methods

    Directory of Open Access Journals (Sweden)

    Irene Benedetti

    2004-01-01

    Full Text Available Local Lipschitz continuity of local minimizers of vectorial integrals ∫Ω f(x,Dudx is proved when f satisfies p-q growth condition and ξ↦f(x,ξ is not convex. The uniform convexity and the radial structure condition with respect to the last variable are assumed only at infinity. In the proof, we use semicontinuity and relaxation results for functionals with nonstandard growth.

  8. QTL Information Table: 740 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available qOVA-4 Resistance or Tolerance Insect resistance ovicidal response to whitebacked p...cidal response to whitebacked planthopper (Sogatella furcifera Horv?th) in rice (Oryza sativa L.) Molecular Breeding 12, 133-143. ... ...lanthopper RFLP C)Interval F2 IR24 Asominori A R1854 C946 pha Yamasaki, M., Yoshimura, A., and Yasui, H. (2003). Genetic basis of ovi

  9. QTL Information Table: 520 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available hd7a Physiological trait Flowering Heading date Mixture C)Interval F3 Zhenshan 97 M...inghui 63 B RM18 R1789 pha Yu, S.B., Li, J.X., Xu, C.G., Tan, Y.F., Li, X.H., and Zhang, Q. (2002). Identifi...cation of quantitative trait loci and epistatic interactions for plant height and heading date in rice. Theor Appl Genet 104, 619-625. ...

  10. 9q22 Deletion - First Familial Case

    Directory of Open Access Journals (Sweden)

    Yamamoto Toshiyuki

    2011-06-01

    Full Text Available Abstract Background Only 29 cases of constitutional 9q22 deletions have been published and all have been sporadic. Most associate with Gorlin syndrome or nevoid basal cell carcinoma syndrome (NBCCS, MIM #109400 due to haploinsufficiency of the PTCH1 gene (MIM *601309. Methods and Results We report two mentally retarded female siblings and their cognitively normal father, all carrying a similar 5.3 Mb microdeletion at 9q22.2q22.32, detected by array CGH (244 K. The deletion does not involve the PTCH1 gene, but instead 30 other gene,s including the ROR2 gene (MIM *602337 which causing both brachydactyly type 1 (MIM #113000 and Robinow syndrome (MIM #268310, and the immunologically active SYK gene (MIM *600085. The deletion in the father was de novo and FISH analysis of blood lymphocytes did not suggest mosaicism. All three patients share similar mild dysmorphic features with downslanting palpebral fissures, narrow, high bridged nose with small nares, long, deeply grooved philtrum, ears with broad helix and uplifted lobuli, and small toenails. All have significant dysarthria and suffer from continuous middle ear and upper respiratory infections. The father also has a funnel chest and unilateral hypoplastic kidney but the daughters have no malformations. Conclusions This is the first report of a familial constitutional 9q22 deletion and the first deletion studied by array-CGH which does not involve the PTCH1 gene. The phenotype and penetrance are variable and the deletion found in the cognitively normal normal father poses a challenge in genetic counseling.

  11. QTL Information Table: 889 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available nori IR24 B C370 C601 pha Liu, L.L., Yan, X.Y., Jiang, L., Zhang, W.W., Wang, M.Q., Zhou, S.R., Shen, Y., Sh...en, Y.Y., Liu, S.J., Chen, L.M., Wang, J.K., and Wan, J.M. (2008). Identification of stably expressed quanti

  12. QTL Information Table: 888 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available nori IR24 B C370 C601 pha Liu, L.L., Yan, X.Y., Jiang, L., Zhang, W.W., Wang, M.Q., Zhou, S.R., Shen, Y., Sh...en, Y.Y., Liu, S.J., Chen, L.M., Wang, J.K., and Wan, J.M. (2008). Identification of stably expressed quanti

  13. QTL Information Table: 890 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available nori IR24 B C370 C601 pha Liu, L.L., Yan, X.Y., Jiang, L., Zhang, W.W., Wang, M.Q., Zhou, S.R., Shen, Y., Sh...en, Y.Y., Liu, S.J., Chen, L.M., Wang, J.K., and Wan, J.M. (2008). Identification of stably expressed quanti

  14. QTL Information Table: 40 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available OSJNBb0074M06 RMw357 RMw353 C80 C1677 pha Wan, X.Y., Wan, J.M., Jiang, L., Wang, J.K., Zhai, H.Q., Weng, J.F., Wang,... H.L., Lei, C.L., Wang, J.L., Zhang, X., Cheng, Z.J., and Guo, X.P. (2006). QTL analysis for rice gr

  15. CONSTRAINED QUADRILATERAL NONCONFORMING ROTATED Q1 ELEMENT

    Institute of Scientific and Technical Information of China (English)

    Jun Hu; Zhong-ci Shi

    2005-01-01

    In this paper, we define a new nonconforming quadrilateral finite element based on the nonconforming rotated Q1 element by enforcing a constraint on each element, which has only three degrees of freedom. We investigate the consistency, approximation, superclose property, discrete Green's function and superconvergence of this element. Moreover, we propose a new postprocessing technique and apply it to this element. It is proved that the postprocessed discrete solution is superconvergent under a mild assumption on the mesh.

  16. QTL Information Table: 539 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Maroof, M.A.S. (1997). Importance of epistasis as the genetic basis of heterosis in an elite rice hybrid. PNAS 94, 9226-9231. http://www.pnas.org/cgi/content/abstract/94/17/9226 ... ...an 97 Minghui 63 B RM1 R753 pha Yu, S.B., Li, J.X., Xu, C.G., Tan, Y.F., Gao, Y.J., Li, X.H., Zhang, Q., and

  17. QTL Information Table: 540 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available ortance of epistasis as the genetic basis of heterosis in an elite rice hybrid. PNAS 94, 9226-9231. http://www.pnas.org/cgi/content/abstract/94/17/9226 ... ...97 Minghui 63 B R19 RZ403 pha Yu, S.B., Li, J.X., Xu, C.G., Tan, Y.F., Gao, Y.J., Li, X.H., Zhang, Q., and Maroof, M.A.S. (1997). Imp

  18. Baxter Q-operator and functional relations

    Directory of Open Access Journals (Sweden)

    A.A. Ovchinnikov

    2015-03-01

    Full Text Available We obtain the Baxter Q-operators in the Uq(slˆ2 invariant integrable models as a special limits of the quantum transfer matrices corresponding to different spins in the auxiliary space. We derive the Baxter equation from the well-known fusion relations for the transfer matrices. Our method is valid for an arbitrary integrable model corresponding to the quantum group Uq(slˆ2, for example for the XXZ-spin chain.

  19. Physical Review X Q&A Session

    Science.gov (United States)

    2014-03-01

    Physical Review X (PRX) is already being recognized as a top-quality journal in physics. What are its current standards and strengths? How will it grow and evolve in the coming years? Why is PRX a journal for you? PRX editors and the Editorial Board invite you to a Q & A session, where we will answer these questions and others you have about the journal. Bring your questions and learn more about PRX. Light refreshments will be provided.

  20. New Curious Bilateral q-Series Identities

    Directory of Open Access Journals (Sweden)

    Frédéric Jouhet

    2012-10-01

    Full Text Available By applying a classical method, already employed by Cauchy, to a terminating curious summation by one of the authors, a new curious bilateral q-series identity is derived. We also apply the same method to a quadratic summation by Gessel and Stanton, and to a cubic summation by Gasper, respectively, to derive a bilateral quadratic and a bilateral cubic summation formula.