Rotational and translational distortions of the crystal structure of the Sr2HrRuO6 (Hr = Ho, Dy, Gd, Eu) complex perovskites

International Nuclear Information System (INIS)

Triana, C.A.; Landínez Téllez, D.A.; Roa-Rojas, J.

2013-01-01

Sr 2 HrRuO 6 (Hr = Ho, Dy, Gd, Eu) complex perovskites were synthesized through the high-temperature solid-state reaction method, and their crystal structures were analyzed in detail as a function of the Hr-cation ionic radius. Results of powder XRD pattern measurement and Rietveld analysis of the experimental profiles show that the Sr 2 HrRuO 6 compounds crystallize in a monoclinic distorted perovskite-like structure, P2 1 /n (#14) space group, where the unit cell parameters are related to the primitive unit cell a p by a≈√(2)a p , b≈√(2)a p and c ≈ 2a p . The structures show an alternate distribution of the Ru 5+ (2d: 0.5, 0, 0) and Hr 3+ (2c: 0, 0.5, 0) making up RuO 6 and HrO 6 octahedra alternatively arranged in two interleaving fcc sublattices, where the O(1), O(2), and O(3) ions are localized at the corner of the octahedral, while the Sr 2+ is located at the A-site, occupying the cavities built by the corner-sharing octahedra with Wyckoff position 4e. Due to the existence of mismatched ionic sizes between the ionic radii of the Sr 2 HrRuO 6 compounds, the HrO 6 and RuO 6 octahedra are constrained to tilting around the [111] c , [001] c , and [110] c cubic directions so as to optimize the Sr–O inter-atomic bond lengths, tending to rotate the structure in order to fix the Ru 5+ and Hr 3+ ions on the M′ and M″ sites of the complex perovskites. The cell parameters a, b, and c, the inter-atomic bond angles, the inter-atomic bond lengths, and the tilting angles increase as the Hr-cation ionic radius increases. The mismatch that exists in the Sr 2 HrRuO 6 ionic radius produces a large distortion from the ideal cubic symmetry. The pure perovskite-like phase of Sr 2 HrRuO 6 is thermodynamically and kinetically stable at high temperatures above 1420 K, where it is entirely governed by the average size of the Hr 3+ and Ru 5+ cations. Highlights: ► Crystal structure of Sr 2 HrRuO 6 (Hr = Ho, Dy, Gd, Eu) as a function of Hr ionic radius. ► XRD

Biota dose assessment of small mammals sampled near uranium mines in northern Arizona

Energy Technology Data Exchange (ETDEWEB)

Jannik, T. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Minter, K. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Kuhne, W. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Kubilius, W. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)

2018-01-09

In 2015, the U. S. Geological Survey (USGS) collected approximately 50 small mammal carcasses from Northern Arizona uranium mines and other background locations. Based on the highest gross alpha results, 11 small mammal samples were selected for radioisotopic analyses. None of the background samples had significant gross alpha results. The 11 small mammals were identified relative to the three ‘indicator’ mines located south of Fredonia, AZ on the Kanab Plateau (Kanab North Mine, Pinenut Mine, and Arizona 1 Mine) (Figure 1-1) and are operated by Energy Fuels Resources Inc. (EFRI). EFRI annually reports soil analysis for uranium and radium-226 using Arizona Department of Environmental Quality (ADEQ)-approved Standard Operating Procedures for Soil Sampling (EFRI 2016a, 2016b, 2017). In combination with the USGS small mammal radioiosotopic tissue analyses, a biota dose assessment was completed by Savannah River National Laboratory (SRNL) using the RESidual RADioactivity-BIOTA (RESRAD-BIOTA, V. 1.8) dose assessment tool provided by the Argonne National Laboratory (ANL 2017).

Global trends and challenges to the HR profession.

OpenAIRE

Prouska, Rea; Cooke, Fang Lee.

2006-01-01

The outsourcing of HR activities is a management strategy that may be adopted in response to a number of pressures that an organization is faced with. It is one aspect of business process outsourcing that is increasingly deployed by firms in order to enhance their organizational competitiveness. HR outsourcing can be defined as ‘placing responsibility for various elements of the HR function with a third-party provider’ (Turnbull, 2002, p.11). In spite of the perceived benefits of HR outsourci...

Do line managers’ have ‘linking pin’ in HR roles?

Directory of Open Access Journals (Sweden)

Mohamed Ayyub Hassan

2015-01-01

Full Text Available Purpose: The present article aims to identify the possible line managers’ involvement factors in human resource (HR initiatives and its ‘linking pin’ to the HR roles. In this regard, few factors have been considered pertinent to line managers’ involvement factors in HR initiatives which are desire, self-efficacy, and HR support. Whereas, the considered dimensions of HR roles reviewed are strategic partner, change agent, employee champion, and administrative expert. Design/methodology/approach: The paper intends to provide a conceptual review of the past literature in the areas of HR roles and line managers and further justify the proposed conceptual framework that will move this work further. Findings: The review also showed that HR devolution to line managers will boost line managers’ participation and responsibility to practice HR roles at the workplace. Research limitations/implications: The main limitation of this review is no empirical evidence provided by the authors to support the literature of the article. All the provided literature is written based on the findings gained from the previous studies. Practical implications: Line managers’ involvement in HR Initiatives can increase the competency diversity among line manager. This in turn can help the organization to operate at high efficiency. Originality/value: There is a notable lack of research conducted to identify line managers’ involvement in HR. Therefore, this article contributes to the literature on the relationship between line managers and HR roles.

FACILITATING RADICAL FRONT-END INNOVATION THROUGH TARGETED HR PRACTICES

DEFF Research Database (Denmark)

Aagaard, Annabeth

2017-01-01

This study examines how radical front end innovation can be actively facilitated through selected and targeted HR practices and bundles of HR practices. The empirical field is an explorative case study of front end innovation and HR practices in the pharmaceutical industry, with an in-depth case ...

Studies on the intracellular localization of hHR23B

International Nuclear Information System (INIS)

Katiyar, Samiksha; Lennarz, William J.

2005-01-01

Yeast Rad23, originally identified as a DNA repair protein, has been proposed to participate in other cellular functions, i.e., the proteasome-degradation pathway, the process of spindle pole body duplication and as a component of the anaphase checkpoint. Two human homologs of yeast Rad23, hHR23A and hHR23B, exhibit high sequence homology with yRad23 and also have been shown to be involved in DNA repair and proteasome-dependent degradation. Previous studies on the intracellular localization of hHR23A and hHR23B revealed their predominant localization in the nucleus during interphase and in the cytoplasm during mitosis. We have analyzed the localization of hHR23B during all the phases of the cell cycle using immunofluorescence. Unlike previous studies, our results suggest localization of hHR23B in the nucleus as well as in the cytoplasm during G1 phase. The nuclear levels of hHR23B decrease during S-phase of the cell cycle. When the cell enters mitosis, hHR23B relocalizes in the cytoplasm without association with chromatin. These results indicate that the intracellular distribution hHR23B is cell cycle dependent

Rotational and translational distortions of the crystal structure of the Sr{sub 2}HrRuO{sub 6} (Hr = Ho, Dy, Gd, Eu) complex perovskites

Energy Technology Data Exchange (ETDEWEB)

Triana, C.A., E-mail: ctrianae@unal.edu.co [Grupo de Física de Nuevos Materiales, Departamento de Física, Universidad Nacional de Colombia, A.A. 5997, Bogotá D.C. (Colombia); Landínez Téllez, D.A. [Grupo de Física de Nuevos Materiales, Departamento de Física, Universidad Nacional de Colombia, A.A. 5997, Bogotá D.C. (Colombia); Roa-Rojas, J., E-mail: jroar@unal.edu.co [Grupo de Física de Nuevos Materiales, Departamento de Física, Universidad Nacional de Colombia, A.A. 5997, Bogotá D.C. (Colombia)

2013-05-15

Sr{sub 2}HrRuO{sub 6} (Hr = Ho, Dy, Gd, Eu) complex perovskites were synthesized through the high-temperature solid-state reaction method, and their crystal structures were analyzed in detail as a function of the Hr-cation ionic radius. Results of powder XRD pattern measurement and Rietveld analysis of the experimental profiles show that the Sr{sub 2}HrRuO{sub 6} compounds crystallize in a monoclinic distorted perovskite-like structure, P2{sub 1}/n (#14) space group, where the unit cell parameters are related to the primitive unit cell a{sub p} by a≈√(2)a{sub p}, b≈√(2)a{sub p} and c ≈ 2a{sub p}. The structures show an alternate distribution of the Ru{sup 5+} (2d: 0.5, 0, 0) and Hr{sup 3+} (2c: 0, 0.5, 0) making up RuO{sub 6} and HrO{sub 6} octahedra alternatively arranged in two interleaving fcc sublattices, where the O(1), O(2), and O(3) ions are localized at the corner of the octahedral, while the Sr{sup 2+} is located at the A-site, occupying the cavities built by the corner-sharing octahedra with Wyckoff position 4e. Due to the existence of mismatched ionic sizes between the ionic radii of the Sr{sub 2}HrRuO{sub 6} compounds, the HrO{sub 6} and RuO{sub 6} octahedra are constrained to tilting around the [111]{sub c}, [001]{sub c}, and [110]{sub c} cubic directions so as to optimize the Sr–O inter-atomic bond lengths, tending to rotate the structure in order to fix the Ru{sup 5+} and Hr{sup 3+} ions on the M′ and M″ sites of the complex perovskites. The cell parameters a, b, and c, the inter-atomic bond angles, the inter-atomic bond lengths, and the tilting angles increase as the Hr-cation ionic radius increases. The mismatch that exists in the Sr{sub 2}HrRuO{sub 6} ionic radius produces a large distortion from the ideal cubic symmetry. The pure perovskite-like phase of Sr{sub 2}HrRuO{sub 6} is thermodynamically and kinetically stable at high temperatures above 1420 K, where it is entirely governed by the average size of the Hr{sup 3+} and Ru

MIGRATION OF ORACLE HR DATABASE

CERN Multimedia

ais.support@cern.ch

2001-01-01

Restricted services from 3 to 7 November 2001 Due to the migration of the Oracle HR application to the Web, some services which rely on the application's availability may be disturbed from Friday 2 November at 17:30 until Thursday 8 November at 08:30. Amongst those services: HR Division: records office, recruitment, claims and benefits. FI Division: personnel accounting, advances and claims. ST Division: registration office (access cards). SPL Division: external firm staff records. EP Division: users' office. Experiments' secretariats: PIE, Greybook. Divisional secretariats: externals, internal addresses. All information concerning this migration is available at: http://ais.cern.ch We apologize for any inconvenience and thank you in advance for your understanding.

NEW PRECISION ORBITS OF BRIGHT DOUBLE-LINED SPECTROSCOPIC BINARIES. IV. 66 ANDROMEDAE, HR 6979, AND HR 9059

International Nuclear Information System (INIS)

Fekel, Francis C.; Williamson, Michael H.; Tomkin, Jocelyn

2010-01-01

We have determined improved spectroscopic orbits for three double-lined binaries, 66 And (F4 V), HR 6979 (Am), and HR 9059 (F5 IV) using radial velocities from the 2.1 m telescope at McDonald Observatory, the coude feed telescope at Kitt Peak National Observatory, and 2 m telescope at Fairborn Observatory. The orbital periods range from 11.0 to 14.3 days, and all three systems have eccentric orbits. The new orbital dimensions (a 1 sin i and a 2 sin i) and minimum masses (m 1 sin 3 i and m 2 sin 3 i) have accuracies of 0.2% or better. All six components of the three binary systems are rotating more slowly than their predicted pseudosynchronous rotational velocities. Hipparcos photometry of HR 9059 shows that this system has partial eclipses. Its components are nearly identical in mass and are at the very end of their main-sequence lifetimes or perhaps have just begun to traverse the Hertsprung gap.

THE IMPACT OF HR MANAGERS’ ROLES ON IMPLEMENTING BEST HR PRACTICES AND ATTRACTING AND RETAINING BEST EMPLOYEES

Directory of Open Access Journals (Sweden)

Nicoleta Valentina FLOREA

2014-10-01

Full Text Available Today’s organizations are facing new challenges, which require them to make effective decisions in order to solve complex issues. These decisions are generally made at higher levels in the organization’s hierarchical structure, where managers maintain power and control to influence organizational goals, including the behaviors and the attitudes of their subordinates. In this article we will show the importance of having effective managers, especially in HR, who can positively influence attracting intellectual capital and acquire knowledge management, by increasing employees motivation, job satisfaction, performance, and organizational commitment, in order to achieve high levels of productivity and efficiency. Also, we will evaluate the HR managers’ roles in order to obtain performance by managing, controlling, evaluating, analyzing, auditing, forecasting, and integrating effectively knowledge management and intellectual capital in organizations. Our study is made in large organizations from Dambovita County, Romania, and it demonstrates that employees need excellent HR managers to obtain the best from them and to face a changing environment.

Daphnia HR96 is a promiscuous xenobiotic and endobiotic nuclear receptor

International Nuclear Information System (INIS)

Karimullina, Elina; Li Yangchun; Ginjupalli, Gautam K.; Baldwin, William S.

2012-01-01

Daphnia pulex is the first crustacean to have its genome sequenced. The genome project provides new insight and data into how an aquatic crustacean may respond to environmental stressors, including toxicants. We cloned Daphnia pulex HR96 (DappuHR96), a nuclear receptor orthologous to the CAR/PXR/VDR group of nuclear receptors. In Drosophila melanogaster, (hormone receptor 96) HR96 responds to phenobarbital exposure and has been hypothesized as a toxicant receptor. Therefore, we set up a transactivation assay to test whether DappuHR96 is a promiscuous receptor activated by xenobiotics and endobiotics similar to the constitutive androstane receptor (CAR) and the pregnane X-receptor (PXR). Transactivation assays performed with a GAL4-HR96 chimera demonstrate that HR96 is a promiscuous toxicant receptor activated by a diverse set of chemicals such as pesticides, hormones, and fatty acids. Several environmental toxicants activate HR96 including estradiol, pyriproxyfen, chlorpyrifos, atrazine, and methane arsonate. We also observed repression of HR96 activity by chemicals such as triclosan, androstanol, and fluoxetine. Nearly 50% of the chemicals tested activated or inhibited HR96. Interestingly, unsaturated fatty acids were common activators or inhibitors of HR96 activity, indicating a link between diet and toxicant response. The omega-6 and omega-9 unsaturated fatty acids linoleic and oleic acid activated HR96, but the omega-3 unsaturated fatty acids alpha-linolenic acid and docosahexaenoic acid inhibited HR96, suggesting that these two distinct sets of lipids perform opposing roles in Daphnia physiology. This also provides a putative mechanism by which the ratio of dietary unsaturated fats may affect the ability of an organism to respond to a toxic insult. In summary, HR96 is a promiscuous nuclear receptor activated by numerous endo- and xenobiotics.

Daphnia HR96 is a promiscuous xenobiotic and endobiotic nuclear receptor

Energy Technology Data Exchange (ETDEWEB)

Karimullina, Elina [Environmental Toxicology Program, Clemson University, Clemson, SC 29634 (United States); Institute of Plant and Animal Ecology, Russian Academy of Sciences, Ural Branch, Yekaterinburg 620144 (Russian Federation); Li Yangchun; Ginjupalli, Gautam K. [Environmental Toxicology Program, Clemson University, Clemson, SC 29634 (United States); Baldwin, William S., E-mail: baldwin@clemson.edu [Environmental Toxicology Program, Clemson University, Clemson, SC 29634 (United States); Biological Sciences, Clemson University, Clemson, SC (United States)

2012-07-15

Daphnia pulex is the first crustacean to have its genome sequenced. The genome project provides new insight and data into how an aquatic crustacean may respond to environmental stressors, including toxicants. We cloned Daphnia pulex HR96 (DappuHR96), a nuclear receptor orthologous to the CAR/PXR/VDR group of nuclear receptors. In Drosophila melanogaster, (hormone receptor 96) HR96 responds to phenobarbital exposure and has been hypothesized as a toxicant receptor. Therefore, we set up a transactivation assay to test whether DappuHR96 is a promiscuous receptor activated by xenobiotics and endobiotics similar to the constitutive androstane receptor (CAR) and the pregnane X-receptor (PXR). Transactivation assays performed with a GAL4-HR96 chimera demonstrate that HR96 is a promiscuous toxicant receptor activated by a diverse set of chemicals such as pesticides, hormones, and fatty acids. Several environmental toxicants activate HR96 including estradiol, pyriproxyfen, chlorpyrifos, atrazine, and methane arsonate. We also observed repression of HR96 activity by chemicals such as triclosan, androstanol, and fluoxetine. Nearly 50% of the chemicals tested activated or inhibited HR96. Interestingly, unsaturated fatty acids were common activators or inhibitors of HR96 activity, indicating a link between diet and toxicant response. The omega-6 and omega-9 unsaturated fatty acids linoleic and oleic acid activated HR96, but the omega-3 unsaturated fatty acids alpha-linolenic acid and docosahexaenoic acid inhibited HR96, suggesting that these two distinct sets of lipids perform opposing roles in Daphnia physiology. This also provides a putative mechanism by which the ratio of dietary unsaturated fats may affect the ability of an organism to respond to a toxic insult. In summary, HR96 is a promiscuous nuclear receptor activated by numerous endo- and xenobiotics.

The Link between HR Attributions and Employees’ Turnover Intentions

Directory of Open Access Journals (Sweden)

Juliana Caesaria Tandung

2016-02-01

Full Text Available Human Resources Management (HRM is part of the organizational functions that contribute to the effectiveness of a firm’s performance, and brings an organization a competitive advantage through the implementation of its Human Resources (HR practices. HR practices adopted by management are perceived or attributed subjectively by individual employees, and can in turn affect the employees’ attitudes and behavior (e.g. Job satisfaction and turnover intention. The purpose of this study is to contribute to the process-based approach by investigating the effect of HR attributions on turnover intentions, with job satisfaction playing a mediating role. The analysis is on the individual level, with 454 respondents from various organizations within the Netherlands. The results show that HR attributions can affect the turnover intention, through the presence of job satisfaction. Thus, it can be said that it is important to always consider the employees’ attitudes and behavior when examining their perception of HR practices, and in predicting their intention to leave.

Enrico Chiaveri: The dialogue in the HR Strategy

CERN Multimedia

2009-01-01

Enrico Chiaveri has been Head of the Human Resources Department since 2005. A core part of his department’s mission with the new Management is to develop and implement a strategic HR approach for our forward-looking Organization. He explained key aspects of the HR strategy to the Bulletin. For the first time in CERN’s history, a head of the HR Department and his deputy - Anne-Sylvie Catherin - invited the staff to a general information meeting on 23 February 2009. The scope of the meeting was to present the status of a number of current initiatives that will improve and tailor CERN’s HR strategy to the needs of the Organization and its staff, and also open up dialogue. Presented for the first time in an integrated way, the initiatives include contract policy, MARS, a staff survey, CERN’s values, a performance model, recruitment & outreach, learning & development, internal mobility and the development of a code of condu...

Transgenic mice display hair loss and regrowth overexpressing mutant Hr gene.

Science.gov (United States)

Zhu, Kuicheng; Xu, Cunshuan; Zhang, Jintao; Chen, Yingying; Liu, Mengduan

2017-10-30

Mutations in the hairless (Hr) gene in both mice and humans have been implicated in the development of congenital atrichia, but the role of Hr in skin and hair follicle (HF) biology remains unknown. Here, we established transgenic mice (TG) overexpressing mutant Hr to investigate its specific role in the development of HF. Three transgenic lines were successfully constructed, and two of them (TG3 and TG8) displayed a pattern of hair loss and regrowth with alternation in the expression of HR protein. The mutant Hr gene inhibited the expression of the endogenous gene in transgenic individuals, which led to the development of alopecia. Interestingly, the hair regrew with the increase in the endogenous expression levels resulting from decreased mutant Hr expression. The findings of our study indicate that the changes in the expression of Hr result in hair loss or regrowth.

Professional Development of HR Practitioners--A Phenomenographic Study

Science.gov (United States)

Bailey, Moira

2015-01-01

Purpose: The purpose of this paper is an investigation into the experiences of professional development of human resource (HR) practitioners in the North of Scotland, and the use of non-formal learning in that development. Design/methodology/approach: In-depth semi-structured interviews from a purposively selected sample of HR practitioners were…

News from HR: a word from Anne-Sylvie Catherin

CERN Multimedia

2016-01-01

Anne-Sylvie Catherin, head of HR Department, looks back over her years at CERN before taking up her new position at the European Central Bank.   At the end of July, I will be leaving CERN on a special leave of absence to take up a new position at the European Central Bank. This is a new chapter in my career, in a new context with its own challenges, and as I prepare for it, I would like to take a little time to look back over my years at CERN and share with you the enriching journey it has been, both for myself and for HR. It has always been my strong belief that any organisation’s greatest asset is its people. When an HR professional believes that, it’s only a short step to the conclusion that the best way to nurture those people is by adopting a professional approach to HR. In this respect, I arrived at a very fortuitous time. Enrico Chiaveri was head of HR and, although his background is in physics, we shared that same conviction. Enrico was the icebreaker in driving change, a...

Data-driven HR how to use analytics and metrics to drive performance

CERN Document Server

Marr, Bernard

2018-01-01

Traditionally seen as a purely people function unconcerned with numbers, HR is now uniquely placed to use company data to drive performance, both of the people in the organization and the organization as a whole. Data-driven HR is a practical guide which enables HR practitioners to leverage the value of the vast amount of data available at their fingertips. Covering how to identify the most useful sources of data, how to collect information in a transparent way that is in line with data protection requirements and how to turn this data into tangible insights, this book marks a turning point for the HR profession. Covering all the key elements of HR including recruitment, employee engagement, performance management, wellbeing and training, Data-driven HR examines the ways data can contribute to organizational success by, among other things, optimizing processes, driving performance and improving HR decision making. Packed with case studies and real-life examples, this is essential reading for all HR profession...

Managing (Sales)People towards Performance: HR Strategy, Leadership & Teamwork

NARCIS (Netherlands)

H.M.S. Dietz (Bart)

2009-01-01

textabstractManaging people towards performance is one of the most critical priorities for managers in practice. This dissertation focuses on this important issue and explores how HR Strategy, Leaders, and Teams, impact performance. It addresses respectively how HR as a system of coherent

The Factors of Forming the National HR-Management Model

Directory of Open Access Journals (Sweden)

Elena P. Kostenko

2017-12-01

Full Text Available There are some factors considered in this article, which influence the forming of national HR-management model. The group-forming criterion is the nature of factors, that determine the system of HR-management as a system of corporate culture values, norms and rules of organizational behavior, ways of realization some important managing functions and dominating approaches to make decisions. This article shows that the plurality of combinations in different factors leads to forming the unique HR-management model. The geoclimatic factor influences the principles of the labor organization (orientation primarily on individual or collective forms of labor, attitude to the management experience of other countries, attitude to resources, etc., the distribution of labor resources, the level of labor mobility, and the psychosocial type of employee. Models of man's labor behavior are constituted In the process of historical development. Attention is focused on the formation of a national HR-model, such as the conducted socio-economic policy, the characteristics of the institutional environment, economic goals and priorities of the country's development, the level of development and the nature of the national productive forces and economic structures. Much attention was paid to the analysis of the historically formed value system and labor traditions, which influence the approaches to HR-management. As far as religion influences the model of person’s inclusion in labor, motives of labor behavior, management culture of a certain employee, preferred payment etc., we examined how the main traditional religions (Christianity, Islam, Judaism, Buddhism, Confucianism, Hinduism influence the HR-management system in different countries.

Proposition for a logical formalism of expression and of temporal properties verification on repetitive events devoted to the analysis of execution traces; Proposition pour un formalisme logique d`expression et de verification de proprietes temporelles sur des evenements repetitifs destine a l`analyse de traces d`execution

Energy Technology Data Exchange (ETDEWEB)

Le Campion, J.M.

1996-01-30

To provide safety analysis of complex real time systems which have been developed for the protection of French nuclear Plants, the CEA is interested in software testing validation techniques. These series of tests are made by a purely software simulation of the system. The purpose is to establish the truth of some critical properties of the programs either at the simulation run time or after its execution. The operator is able to describe the variation of some inputs parameters of the programs and shows the results with graphics facilities. An important need was to describe formally some categories of properties expressed in terms of academic examples. We thought that a logical textual language was appropriate to achieve this formal expression. This thesis describe a new data-flow language called EFRI extending the semantic of interval temporal logics. Then we describe a calculus using regular languages on arrays which associates to each formula of the EFRI language a regular expression. With this method, the verification of a property described by a formula of EFRI can be viewed as a classical problem of languages theory: does a word belongs to a regular language. We can then build a finite automaton to recognize complex temporal diagrams. (author). 38 refs., 7 tabs., 4 appends.

Outsourcing HR Services: The Role of Human Resource Intermediaries

Science.gov (United States)

Kock, Henrik; Wallo, Andreas; Nilsson, Barbro; Hoglund, Cecilia

2012-01-01

Purpose: In this article, the area of interest is an emerging type of organisation called human resource intermediaries (HRIs), which focus on delivering human resource (HR) services to public sector organisations and private companies. The purpose of this article is, thus, to explore HRIs as deliverers of HR services. More specifically, the…

African American Accounting Majors and the 150-hr Requirement

Science.gov (United States)

Booker, Quinton; Hill, Cecil L.; Wright, Carl

2010-01-01

The study provides information on African American accounting majors' views regarding 150-hr issues. The authors collected data from 152 students at two schools. Students at one school supported the requirement while those at the other school did not. However, students believed that the 150-hr requirement enhances the quality of certified public…

Enabling quaternion derivatives: the generalized HR calculus

Science.gov (United States)

Xu, Dongpo; Jahanchahi, Cyrus; Took, Clive C.; Mandic, Danilo P.

2015-01-01

Quaternion derivatives exist only for a very restricted class of analytic (regular) functions; however, in many applications, functions of interest are real-valued and hence not analytic, a typical case being the standard real mean square error objective function. The recent HR calculus is a step forward and provides a way to calculate derivatives and gradients of both analytic and non-analytic functions of quaternion variables; however, the HR calculus can become cumbersome in complex optimization problems due to the lack of rigorous product and chain rules, a consequence of the non-commutativity of quaternion algebra. To address this issue, we introduce the generalized HR (GHR) derivatives which employ quaternion rotations in a general orthogonal system and provide the left- and right-hand versions of the quaternion derivative of general functions. The GHR calculus also solves the long-standing problems of product and chain rules, mean-value theorem and Taylor's theorem in the quaternion field. At the core of the proposed GHR calculus is quaternion rotation, which makes it possible to extend the principle to other functional calculi in non-commutative settings. Examples in statistical learning theory and adaptive signal processing support the analysis. PMID:26361555

CROATIAN ADULT SPOKEN LANGUAGE CORPUS (HrAL

Directory of Open Access Journals (Sweden)

Jelena Kuvač Kraljević

2016-01-01

Full Text Available Interest in spoken-language corpora has increased over the past two decades leading to the development of new corpora and the discovery of new facets of spoken language. These types of corpora represent the most comprehensive data source about the language of ordinary speakers. Such corpora are based on spontaneous, unscripted speech defined by a variety of styles, registers and dialects. The aim of this paper is to present the Croatian Adult Spoken Language Corpus (HrAL, its structure and its possible applications in different linguistic subfields. HrAL was built by sampling spontaneous conversations among 617 speakers from all Croatian counties, and it comprises more than 250,000 tokens and more than 100,000 types. Data were collected during three time slots: from 2010 to 2012, from 2014 to 2015 and during 2016. HrAL is today available within TalkBank, a large database of spoken-language corpora covering different languages (https://talkbank.org, in the Conversational Analyses corpora within the subsection titled Conversational Banks. Data were transcribed, coded and segmented using the transcription format Codes for Human Analysis of Transcripts (CHAT and the Computerised Language Analysis (CLAN suite of programmes within the TalkBank toolkit. Speech streams were segmented into communication units (C-units based on syntactic criteria. Most transcripts were linked to their source audios. The TalkBank is public free, i.e. all data stored in it can be shared by the wider community in accordance with the basic rules of the TalkBank. HrAL provides information about spoken grammar and lexicon, discourse skills, error production and productivity in general. It may be useful for sociolinguistic research and studies of synchronic language changes in Croatian.

Value creation through HR shared services: towards a conceptual framework

NARCIS (Netherlands)

Meijerink, Jeroen Gerard; Bondarouk, Tatiana; Looise, Jan C.

2013-01-01

Purpose – The purpose of this paper is to derive a measure for the performance of human resource shared service providers (HR SSPs) and then to develop a theoretical framework that conceptualises their performance. Design/methodology/approach – This conceptual paper starts from the HR shared

CERN HR receives award for on-line recruitment and communication

CERN Multimedia

Joannah Caborn Wengler

2012-01-01

In a survey of 21,000 European students, CERN ranked 15th, ahead of giants like Microsoft and Nestlé, for the quality of its on-line "talent communication", that is how it uses the Internet to attract job applicants. HR now boasts a new virtual award, certifying its on-line savvy.   The "virtual" award given to HR. How did you get your job at CERN? Via the CERN HR website, or Facebook, or Twitter? Or were you headhunted on LinkedIn? Particularly if you’re from the younger generation, chances are that you used some form of on-line recruitment. In this case you will have used one of the best recruitment tools in Europe, according to the 2012 OTaC (Online Talent Communication) study, carried out by a research institute named Potentialpark. It surveyed over 21,000 students, asking them to rate employers’ use of seven different channels of communication about jobs and careers, from HR websites and on-line application systems to the...

PLEIADES-HR IMAGE QUALITY COMMISSIONING

Directory of Open Access Journals (Sweden)

L. Lebègue

2012-07-01

Full Text Available PLEIADES is the highest resolution civilian earth observing system ever developed in Europe. This imagery program is conducted by the French National Space Agency, CNES. It operates since 2012 a first satellite PLEIADES-HR launched on 2011 December 17th, a second one should be launched by the end of the year. Each satellite is designed to provide optical 70 cm resolution coloured images to civilian and defence users. The Image Quality requirements were defined from users studies from the different spatial imaging applications, taking into account the trade-off between on-board technological complexity and ground processing capacity. The assessment of the image quality and the calibration operation have been performed by CNES Image Quality team during the 6 month commissioning phase that followed the satellite launch. These activities cover many topics gathered in two families : radiometric and geometric image quality. The new capabilities offered by PLEIADES-HR agility allowed to imagine new methods of image calibration and performance assessment. Starting from an overview of the satellite characteristics, this paper presents all the calibration operations that were conducted during the commissioning phase and also gives the main results for every image quality performance.

Composite Spectra Paper 1: HR 6902

Indian Academy of Sciences (India)

tribpo

spectra; in many cases we have used the maximum width permitted by the optics of ... 10 mЕ, corresponding to 1 µm the plate, are the norm. ..... an inequality ..... on the spectra of HR 6902, we have thought it appropriate to weight the four ...

Why a well-designed HR shared service provider fails to create end-user value?

NARCIS (Netherlands)

Meijerink, Jeroen Gerard; Bondarouk, Tatiana; Looise, Jan C.

2011-01-01

Human resource shared services centres (HR SSCs) are foreseen as improving HR service delivery for their end-users: employees, line managers and decentralized HR professionals. Although the concept expects the benefits of HR SSCs to come from centralizing knowledge and decentralizing the control

Validation of calcaneus trabecular microstructure measurements by HR-pQCT.

Science.gov (United States)

Metcalf, Louis M; Dall'Ara, Enrico; Paggiosi, Margaret A; Rochester, John R; Vilayphiou, Nicolas; Kemp, Graham J; McCloskey, Eugene V

2018-01-01

Assessment of calcaneus microstructure using high-resolution peripheral quantitative computed tomography (HR-pQCT) might be used to improve fracture risk predictions or to assess responses to pharmacological and physical interventions. To develop a standard clinical protocol for the calcaneus, we validated calcaneus trabecular microstructure measured by HR-pQCT against 'gold-standard' micro-CT measurements. Ten human cadaveric feet were scanned in situ using HR-pQCT (isotropic 82μm voxel size) at 100, 150 and 200ms integration times, and at 100ms integration time following removal of the calcaneus from the foot (ex vivo). Dissected portions of these bones were scanned using micro-computed tomography (micro-CT) at an isotropic 17.4μm voxel size. HR-pQCT images were rigidly registered to those obtained with micro-CT and divided into multiple 5mm sided cubes to evaluate and compare morphometric parameters between the modalities. Standard HR-pQCT measurements (derived bone volume fraction (BV/TV d ); trabecular number, Tb.N; derived trabecular thickness, Tb.Th d ; derived trabecular spacing, Tb.Sp d ) and corresponding micro-CT voxel-based measurements (BV/TV, Tb.N, Tb.Th, Tb.Sp) were compared. A total of 108 regions of interest were analysed across the 10 specimens. At all integration times HR-pQCT BV/TV d was strongly correlated with micro-CT BV/TV (r 2 =0.95-0.98, RMSE=1%), but BV/TV d was systematically lower than that measured by micro-CT (mean bias=5%). In contrast, HR-pQCT systematically overestimated Tb.N at all integration times; of the in situ scans, 200ms yielded the lowest mean bias and the strongest correlation with micro-CT (r 2 =0.61, RMSE=0.15mm -1 ). Regional analysis revealed greater accuracy for Tb.N in the superior regions of the calcaneus at all integration times in situ (mean bias=0.44-0.85mm -1 ; r 2 =0.70-0.88, pmicrostructure, particularly in the superior region of the calcaneus, can be assessed by HR-pQCT. The highest integration time

Journeys on the H-R diagram

International Nuclear Information System (INIS)

Kaler, J.B.

1988-01-01

The evolution of various types of stars along the H-R diagram is discussed. Star birth and youth is addressed, and the events that occur due to core contraction, shell burning, and double-shell burning are described. The evolutionary courses of planetary nebulae, white dwarfs, and supernovas are examined

Comments on H.R. 2480

International Nuclear Information System (INIS)

Rezendes, V.S.

1990-10-01

GAO testified on H.R. 2480, the Uranium Enrichment Reorganization Act, which would restructure DOE's uranium enrichment program as a government corporation. Specifically, this legislation would allow the corporation to set prices to maximize long-term returns; establish a fund to meet future decontamination, decommissioning, and remedial action costs associated with past uranium enrichment activities. and require the government to pay its share of the costs to clean up mining waste generated under past government contracts. GAO believes that H.R. 2480 takes needed steps toward establishing clear objectives for the enrichment program and would allow the new corporation to better operate as a business entity. The bill would also resolve several long-term issues that seriously challenge the program's future, including the need to pay billions of dollars in environmental and decommissioning costs at a time when competition is expected to increase. However, GAO believes that the bill could be strengthened by including a specific cost recovery provision. Because DOE projects that the corporation's future earnings could be substantial, GAO suggests that Congress require the repayment of $3 billion, rather than rely solely on unspecified dividends and/or uncertain future stock sales that may not materialize unless problems related to licensing uncertainties, increased competition, and billions of dollars in liabilities are adequately resolved

Esprit HR mattress cover in pressure ulcer prevention.

Science.gov (United States)

Khoulowa, J

Modern mattresses provide soft dense foam, which permits the redistribution of pressure on the patient over a wider area - away from bony prominences where pressure ulcers usually occur. The material used in producing multistretch covers for the new mattresses had a tendency to delaminate as a result of a combination of heat, moisture and inappropriate cleansing techniques causing the water barriers to fall. In partnership with York Health NHS Trust and the material manufacturer, STM Healthcare produced a mattress cover (Esprit HR) which was able to withstand higher pressure from heat and moisture and greatly extended the life expectancy of the Esprit HR mattress.

PLEIADES-HR INNOVATIVE TECHNIQUES FOR RADIOMETRIC IMAGE QUALITY COMMISSIONING

Directory of Open Access Journals (Sweden)

G. Blanchet

2012-07-01

Full Text Available The first Pleiades-HR satellite, part of a constellation of two, has been launched on December 17, 2011. This satellite produces high resolution optical images. In order to achieve good image quality, Pleiades-HR should first undergo an important 6 month commissioning phase period. This phase consists in calibrating and assessing the radiometric and geometric image quality to offer the best images to end users. This new satellite has benefited from technology improvements in various fields which make it stand out from other Earth observation satellites. In particular, its best-in-class agility performance enables new calibration and assessment techniques. This paper is dedicated to presenting these innovative techniques that have been tested for the first time for the Pleiades- HR radiometric commissioning. Radiometric activities concern compression, absolute calibration, detector normalization, and refocusing operations, MTF (Modulation Transfer Function assessment, signal-to-noise ratio (SNR estimation, and tuning of the ground processing parameters. The radiometric performances of each activity are summarized in this paper.

A nonlinear filtering algorithm for denoising HR(S)TEM micrographs

International Nuclear Information System (INIS)

Du, Hongchu

2015-01-01

Noise reduction of micrographs is often an essential task in high resolution (scanning) transmission electron microscopy (HR(S)TEM) either for a higher visual quality or for a more accurate quantification. Since HR(S)TEM studies are often aimed at resolving periodic atomistic columns and their non-periodic deviation at defects, it is important to develop a noise reduction algorithm that can simultaneously handle both periodic and non-periodic features properly. In this work, a nonlinear filtering algorithm is developed based on widely used techniques of low-pass filter and Wiener filter, which can efficiently reduce noise without noticeable artifacts even in HR(S)TEM micrographs with contrast of variation of background and defects. The developed nonlinear filtering algorithm is particularly suitable for quantitative electron microscopy, and is also of great interest for beam sensitive samples, in situ analyses, and atomic resolution EFTEM. - Highlights: • A nonlinear filtering algorithm for denoising HR(S)TEM images is developed. • It can simultaneously handle both periodic and non-periodic features properly. • It is particularly suitable for quantitative electron microscopy. • It is of great interest for beam sensitive samples, in situ analyses, and atomic resolution EFTEM

Bringing human resources to the table: utilization of an HR balanced scorecard at Mayo Clinic.

Science.gov (United States)

Fottler, Myron D; Erickson, Eric; Rivers, Patrick A

2006-01-01

Rather than viewing HR as a critical driver of organizational strategy and outcomes, most health care organizations see HR as a drain on the organization's bottom line. Only by aligning HR with the organizational strategy will HR leaders truly get a seat at the leadership table. HR professionals can overcome impediments and gain a seat at the table by learning the language of business and the ways in which organizational leaders use data to drive their decisions. This article shows how Mayo Clinic uses the popular Balanced Scorecard approach to align its measures of HR performance to the organization's strategic plan.

Comparison between Pentacam HR and Orbscan II after hyperopic photorefractive keratectomy

Directory of Open Access Journals (Sweden)

Mahmoud Jabbarvand

2017-01-01

Conclusion: Pentacam HR and Orbscan II after PRK for hyperopia show reasonable agreement for determining A-BFS, P-BFS, A-TG3, and CCT, but not for A-CE, P-CE, A-TG5, or ACD. CCT measurements with Pentacam HR have reasonable agreement with US pachymetry.

Distribution of ABO and Rh-Hr blood group antigens, alleles and ...

African Journals Online (AJOL)

ABO and Rh-Hr blood group antigens represent a genetically stably determined trait with many-sided biological and clinical significance. The indigenous Ajarian population (105 subjects) was investigated for ABO Rh-Hr red cell blood group antigens. Using immunoserologic methods, seven blood group antigens (A, B, C, c, ...

LBT observations of the HR8799 planetary system

Science.gov (United States)

Mesa, D.; Arcidiacono, C.; Claudi, R. U.; Desidera, S.; Esposito, S.; Gratton, R.; Masciadri, E.

2013-09-01

We present here observations of the HR8799 planetary system performed in H and Ks band exploiting the AO system at the Large Binocular Telescope and the PISCES camera. Thanks to the excellent performence of the instrument we were able to detect for the first time the inner known planet of the system (HR8799) in the H band. Precise photometric and astrometric measures have been taken for all the four planets. Further, exploiting ours and previous astrometric results, we were able to put some limits on the planetary orbits of the four planets. The analysis of the dinamical stability of the system seems to show lower planetary masses than the ones adopted until now.

阴道滴虫与宫颈HR-HPV感染及宫颈癌发生的相关性%Association about Trichomonas, HR-HPV Infection and Cervical Carcinoma

Institute of Scientific and Technical Information of China (English)

李旻; 郭会芹; 陈凤; 曹箭; 李中林; 张询; 潘秦镜

2007-01-01

目的 探讨阴道滴虫是否能增加高危人乳头瘤病毒(HR-HPV)感染和宫颈癌发生的危险.方法 对受检者进行液基细胞学检查和HR-HPV DNA检测,并在细胞学诊断中记录是否存在滴虫.对所有细胞学诊断非典型鳞状细胞(ASC)及以上病变、HR-HPV DNA阳性病例和部分细胞学阴性及HR-HPV DNA阴性病例进行阴道镜检查及活检.分别比较滴虫在HR-HPV DNA阳性组和阴性组、细胞学及组织学各级诊断中的存在率.结果 在13 024例受检者中有1 687例(12.95%)涂片中有滴虫.滴虫存在率在HR-HPV DNA阳性组与阴性组中无显著统计学差异(P＞0.05),在细胞学阴性病例组显著高于鳞状上皮内病变组(P＜0.05),在组织学阴性病例组显著高于在≥CIN2病例组(P＜0.05).结论 滴虫的存在不增加HR-HPV感染率,也不增加宫颈癌发生的危险.

HR practices for enhancing sustainable employability : implementation, use, and outcomes

OpenAIRE

Ybema, Jan Fekke; van Vuuren, Tinka; van Dam, Karen

2017-01-01

With the aging of the workforce, organizations need to maintain or improve the sustainable employability of their workforce throughout their working life. This raises the question which HR practices increase workers’ sustainable employability at work. The aim of this study is to investigate the extent to which organizations implement HR practices for enhancing sustainable employability in terms of workers’ health, motivation, and skills and knowledge from the employer’s perspective. In total,...

The composite nature of the peculiar star HR 6560 (HD 159870)

Science.gov (United States)

Wegner, Gary; Cowley, Charles R.

1992-01-01

Ground-based high-dispersion photographic spectra and ultraviolet spectra obtained with the IUE satellite are described and employed to determine the nature of the peculiar star HR 6560 (HD 159870). Previously this object had been described as both a composite system and as a strong Fm star. The UBVRI, Stromgren, and ultraviolet colors of HR 6560 are compared with objects classified composite from the Bright Star Catalogue and normal dwarfs and giants. The colors of HR 6560 are not unusual for a composite and are consistent with a late-A dwarf, combined with a late-G or early-K giant. The ultraviolet satellite clearly shows the presence of an A component, but its precise spectral type is difficult to assign. The IUE and TD-1 data suggest that the ultraviolet is dominated by light from an A5 V secondary and the visual from a GO III primary. This does not agree well with the most plausible model that fits the visual photometry. The peculiar nature of HR 6560's spectrum is most likely due to its composite nature.

Classification of Ap-stars HR 830 and ZI CVn

International Nuclear Information System (INIS)

Zverko, J.

1984-01-01

Two ambiguously classified Ap-stars, HR 830 and 21 CVn, are studied. The observational data are compared with the data for normal stars αDel and αLyr. Star HR 830 is classified as Ap of type Si based on the enhanced absorption in the Si lines and photometric variability in UBV. 21 CVn is classified as Ap Si based on weaker absorption of helium, the variability of helium lines, photometric periodic variability and the properties of the UV spectrum. It is concluded that the photometric periodic variability is a good indicator of Ap-properties of rapidly rotating A and late B stars. (author)

Safety of DOE nuclear facilities. Hearings before the Subcommittee on Energy and Power of the Committee on Energy and Commerce, House of Representatives, One Hundredth Congress, First Session, H.R. 783, H.R. 2047 and H.R. 3123, November 5 and 19, 1987

International Nuclear Information System (INIS)

Anon.

1988-01-01

H.R. 783 is a bill to require the Secretary of Energy to ensure the compliance of certain operations of the Department of Energy (DOE) with Federal environmental standards and for other purposes. H.R. 2047 is a bill to establish a Defense Nuclear Facilities Safety Agency in order to provide for increased standards of safety with respect to radioactive emissions resulting from activities carried out at nuclear facilities of DOE. H.R. 3123 is a bill to create an independent oversight board to ensure the safety of United States Government nuclear facilities, to apply the provisions of OSHA to certain DOE nuclear facilities, to clarify the jurisdiction and powers of Government agencies dealing with nuclear wastes, to ensure independent research on the effects of radiation on human beings, and for other purposes

Daily self-sampling for high-risk human papillomavirus (HR-HPV) testing.

Science.gov (United States)

Sanner, Karin; Wikström, Ingrid; Gustavsson, Inger; Wilander, Erik; Lindberg, Julia Hedlund; Gyllensten, Ulf; Olovsson, Matts

2015-12-01

Self-sampling for HPV as part of primary screening is a well-tolerated method for women not attending organized Pap smear screening and could increase coverage of cervical cancer screening. To investigate if the prevalence of HR-HPV varies from day to day in infected women and if one single sample is reliable for detecting an ongoing infection. This is a prospective cohort study on 12 premenopausal and 13 postmenopausal women performing daily self-sampling for HR-HPV testing. They were all HR-HPV-positive 1-3 months ago. Postmenopausal women were sampled for 28 days and premenopausal women sampled during bleeding-free days in one menstrual cycle. A possible difference in viral load between the estrogen-dominated proliferative phase and the progesterone-dominated secretory phase was analyzed. Consistent results throughout the sampling period were observed for 19 women, with either a daily presence of HPV (14 women) or no HPV at all during the sampling period (5 women). Of 607 samples from 25 women, 596 were consistently positive or negative for HPV during the sampling period and 11 were inconsistent (2%). There was no difference in HPV copy number between the estrogen dominated proliferative or progesterone dominated secretory menstrual cycle phases. The major finding was a high degree of consistency concerning HR-HPV positivity and negativity of HR-HPV in vaginal fluid during a sustained period of daily self-sampling. It does not appear to matter whether the sample is collected in the proliferative or secretory phase. Copyright © 2015 Elsevier B.V. All rights reserved.

Qualitative risk assessment for the 100-HR-3 groundwater operable unit

Energy Technology Data Exchange (ETDEWEB)

Vukelich, S.E. [Golder Associates, Inc., Richland, WA (United States)

1994-09-22

This report provides the qualitative risk assessment for the 100-HR-3 operable unit on the Hanford Reservation. 100-HR-3 is a ground water unit. The purpose of the QRA at the 100-HR-3 operable unit is to focus on a predefined set of human and environmental exposure scenarios in order to provides sufficient information that will assist the Tri-Party signatories (Washington State Department of Ecology, EPA and US DOE) in making defensible decisions on the necessity of Interim Remedial Measures. Frequent- and occasional-use exposure scenarios are evaluated in the human health risk assessment to provide bounding estimates of risk. The ecological risk assessment consists of an evaluation of the risks to riparian and aquatic receptors which live in or near the Columbia River.

Qualitative risk assessment for the 100-HR-3 groundwater operable unit

International Nuclear Information System (INIS)

Vukelich, S.E.

1994-01-01

This report provides the qualitative risk assessment for the 100-HR-3 operable unit on the Hanford Reservation. 100-HR-3 is a ground water unit. The purpose of the QRA at the 100-HR-3 operable unit is to focus on a predefined set of human and environmental exposure scenarios in order to provides sufficient information that will assist the Tri-Party signatories (Washington State Department of Ecology, EPA and US DOE) in making defensible decisions on the necessity of Interim Remedial Measures. Frequent- and occasional-use exposure scenarios are evaluated in the human health risk assessment to provide bounding estimates of risk. The ecological risk assessment consists of an evaluation of the risks to riparian and aquatic receptors which live in or near the Columbia River

International HR Strategy of Brazilian Technology Multinationals

Directory of Open Access Journals (Sweden)

Patricia Morilha Muritiba

2010-10-01

Full Text Available Four cases of Brazilian Multinationals from the information technology [IT] sector were compared in their international Human Resources strategy. The analysis is focused on the development and application of two research models. One analyzes the level of subsidiary autonomy in terms of strategic HR decisions, including difficult decisions regarding coordination in multinationals, following the theoretical approach of the autonomy of subsidiaries (Kidger, 2002; Nohria & Ghoshal, 1997. The other is related to the level of internationalization of HR strategies, defined as the capacity to take advantage of globalization, providing the best resources for the company regardless of where they are located (Sparrow, 2007. Both models were applied in a multiple case study method (Eisenhardt, 1989. Data were collected through semi-structured interviews and company reports, and analyzed through content analysis. The results show: (a a more centralizing characteristic of the multinational companies examined, despite the limitations of this choice as shown by the literature; and (b that Brazilian IT multinationals tend to rely more on their national competencies when managing human resources instead of going global to aggregate differentiated competencies.

THE IMPACT OF HR MANAGERS’ ROLES ON IMPLEMENTING BEST HR PRACTICES AND ATTRACTING AND RETAINING BEST EMPLOYEES

OpenAIRE

Nicoleta Valentina FLOREA

2014-01-01

Today’s organizations are facing new challenges, which require them to make effective decisions in order to solve complex issues. These decisions are generally made at higher levels in the organization’s hierarchical structure, where managers maintain power and control to influence organizational goals, including the behaviors and the attitudes of their subordinates. In this article we will show the importance of having effective managers, especially in HR, who can positively influence attrac...

Exploring the central characteristics of HR shared services: evidence from a critical case study in the Netherlands

NARCIS (Netherlands)

Meijerink, Jeroen Gerard; Bondarouk, Tatiana

2012-01-01

Human resource shared service centers (HR SSCs) are foreseen as improving HR service delivery for their end-users: employees, line managers and decentralized HR professionals. Although the concept expects the benefits of HR SSCs to come from centralizing knowledge and decentralizing the control

A Role For HR In Corporate Ethics? South African Practitioners’ Perspectives

OpenAIRE

L. J. van Vuuren; R. J. Eiselen

2006-01-01

Since few South African organisations have as yet appointed ethics officers, there is often a lack of clarity on who should take responsibility for coordinating organisations’ ethics management efforts. The purpose of this paper was to assess HR (the Human Resource function and its practitioners) as a possible contender to assume responsibility for ethics management in SA organisations. To this end a mail survey was conducted among registered HR practitioners (N=410). Two factors related to 1...

Limited field investigation report for the 100-HR-3 operable unit

International Nuclear Information System (INIS)

1994-09-01

This limited field investigation (LFI) was conducted to assess the applicability of interim remedial measures (IRM) for reducing human health and environmental risks within the 100-HR-3 Groundwater Operable Unit. The 100-HR-3 Operable Unit is comprised of three subareas; the 100 D Area, the 100 H Area and those portions of the 600 Area between the two reactor areas. The operable unit is one of seven operable units associated with the 100 D and H Areas. Operable units 100-DR-1, 100-DR-2, 100-DR-3, 100-HR-1, 100-HR-2 and 100-IU-4 address contaminant sources while 100-HR-3 addresses contamination present in the underlying groundwater. The primary method of field investigation used during this LFI was the installation and sampling of monitoring wells. Samples were collected from the groundwater and soils, and submitted for laboratory analysis. Boreholes were surveyed for radiological contamination using downhole geophysical techniques to further delineate the locations and levels of contaminants. All samples were screened to ascertain the presence of volatile organic compounds and radionuclides. Analytical data were subjected to validation; all round one, two and three and a minimum of 10% of round four data associated with the LFI were validated. A screening method was used to identify contaminants of potential concern (COPC). This screening method eliminated from further consideration, constituents that were below background. Constituents which are considered non-toxic to humans were eliminated from the human health evaluation. Data consistency and blank contamination were also evaluated in the screening process. These COPC were then evaluated further in the qualitative risk assessment (QRA). A human health QRA was performed using conservative (maximum equilibrated contaminant levels from the LFI) analyses

Comparative evaluation of heart rate-based monitors: Apple Watch vs Fitbit Charge HR.

Science.gov (United States)

Bai, Yang; Hibbing, Paul; Mantis, Constantine; Welk, Gregory J

2018-08-01

The purpose of this investigation was to examine the validity of energy expenditure (EE), steps, and heart rate measured with the Apple Watch 1 and Fitbit Charge HR. Thirty-nine healthy adults wore the two monitors while completing a semi-structured activity protocol consisting of 20 minutes of sedentary activity, 25 minutes of aerobic exercise, and 25 minutes of light intensity physical activity. Criterion measures were obtained from an Oxycon Mobile for EE, a pedometer for steps, and a Polar heart rate strap worn on the chest for heart rate. For estimating whole-trial EE, the mean absolute percent error (MAPE) from Fitbit Charge HR (32.9%) was more than twice that of Apple Watch 1 (15.2%). This trend was consistent for the individual conditions. Both monitors accurately assessed steps during aerobic activity (MAPE Apple : 6.2%; MAPE Fitbit : 9.4%) but overestimated steps in light physical activity. For heart rate, Fitbit Charge HR produced its smallest MAPE in sedentary behaviors (7.2%), followed by aerobic exercise (8.4%), and light activity (10.1%). The Apple Watch 1 had stronger validity than the Fitbit Charge HR for assessing overall EE and steps during aerobic exercise. The Fitbit Charge HR provided heart rate estimates that were statistically equivalent to Polar monitor.

Can HR practices retain flexworkers with their agency?

NARCIS (Netherlands)

Kroon, B.; Freese, C.

2013-01-01

Purpose Workers have different motives to be employed at specialist contract work agencies, such as career development aspirations, or a desire for freedom and independence. The purpose of this paper is to study how these different motives relate to the appreciation of HR practices applied by

The latest on the recent HR staff survey

CERN Multimedia

2009-01-01

The data collected in the framework of the staff survey sent out by the Human Resources (HR) Department in March this year are currently being analysed. The first results concern the response rate and the breakdown of participants. 1328 staff members replied to the questionnaire, representing a response rate of close to 60%. Marie-Luce Falipou, who is in charge of the project within the HR Department, is evidently satisfied with the result: "The high response rate shows that the staff appreciated HR’s efforts to sound out their opinions and felt concerned by the subjects covered in the questionnaire". All the data are now being processed by the team led by Philippe Sarnin, Director of the Social Psychology Department at the University of Lyon2. "The number of responses submitted during the 15 days the form was available on line was very satisfactory. This is a vital factor in ensuring that we are able to build up an accurate pictu...

A Role For HR In Corporate Ethics? South African Practitioners’ Perspectives

Directory of Open Access Journals (Sweden)

L. J. van Vuuren

2006-11-01

Full Text Available Since few South African organisations have as yet appointed ethics officers, there is often a lack of clarity on who should take responsibility for coordinating organisations’ ethics management efforts. The purpose of this paper was to assess HR (the Human Resource function and its practitioners as a possible contender to assume responsibility for ethics management in SA organisations. To this end a mail survey was conducted among registered HR practitioners (N=410. Two factors related to 1 the extent of HR’s ethics management competence and 2 HR’s responsibility for ethics management, were identified. The results showed that HR practitioners on average believe that they indeed have an ethics management competence and that they should be involved in ethics management. However, practitioners with a great deal of exposure to organisations that manage ethics believe to a lesser extent that they should be involved in ethics management. The implications of the findings are discussed.

Clinical evaluation of wide-latitude HR-C film for chest radiography

International Nuclear Information System (INIS)

Kim, Young Sung; Hwang, Nam Sun; Yeo, Young Bok; Lee, In Ja; Huh, Joon

1990-01-01

In application of wide latitude HR-C film to chest x-ray examination, former x-ray diagnosis area is larger and diagnostic information has great deal of promotion. HR-C film is compare to former x-ray film is larger latitude and density level is small, reading is very easily. Especially, high estimate that is in characteristic curve linearity of toe part is good, contrast of low density made good shape and not good describe to overlap is diagnostic information increase mediastinum portion etc

Employee Work-Life Balance as an HR Imperative | Igbinomwanhia ...

African Journals Online (AJOL)

Employee Work-Life Balance as an HR Imperative. ... With the growing diversity of family structures represented in today‟s workforce, ... of managing an employee's work-life balance have increased markedly over the past 20 years.

Learning Culture, Line Manager and HR Professional Practice

Science.gov (United States)

Harrison, Patricia

2011-01-01

Purpose: This paper aims to focus on the role of line management and learning culture in the development of professional practice for the human resource (HR) practitioner. Design/methodology/approach: Three-year longitudinal, matched-pair study involving five participants and their line managers. Findings: Two of the five participants experienced…

Discussion on the fusing methods for HR and CCD images of CBERS

International Nuclear Information System (INIS)

Gao Zhangsheng; Zhao Yingjun

2010-01-01

CBERS-02B multi-spectral CCD data are different from HR panchromatic data in resolution, which causes difficulty in image fusion. With the method of Pansharping, HPF, Brovey transform, IHS transform, principal component transform, Gram Schmidt (GS) transform and wavelet transform, the authors have tested the fusion methods for CCD data and HR data of CBERS, and the fusion results are discussed and evaluated qualitatively and quantitatively. (authors)

Is the standard dose rate for de-contamination, 0.23 mc-Sv/hr, truly 1 mSv/year?

International Nuclear Information System (INIS)

Furuta, Sadaaki

2014-01-01

Examined is the validity of the standard dose rates in the title, which have been additionally defined by Ministry of the Environment (ME) to the measures of Fukushima Nuclear Power Plant Accident. The standard 0.23 mc-Sv/hr is the sum of natural ambient dose rate 0.04 mc-Sv/hr in average of Japan as measured with NaI scintillation surveymeter, plus additional accidental exposure dose 1 mSv/y, which is defined equivalent to 0.19 mc-Sv/hr. Here, the equation of addition 0.04+0.19 mc-Sv/hr is not exactly correct because the unit of each dose value has different means as follows. The natural dose is derived from the value 5.8 mc-R/hr (0.038 mc-Sv/hr, effective dose) of the average national natural dose data (2011) of Ministry of Education, Culture, Sports, Science and Technology. However, if the measurement is done with the surveymeter which practically gives 1 cm dose equivalent, the rate is calculated to be 0.06 mc-Sv/hr. When the Fukushima prefectural natural dose rate 6.4 mc-R/hr is employed, the calculation gives 0.07 mc-Sv/hr. ME defines the additional doses to be 0.19 mc-Sv/hr and 1 mSv/y, which are derived from the calculation: (0.19 mc-Sv/hr x 8 hr outdoor + 0.19 mc-Sv/hr x 0.4 indoor, shielded) x 365 d/y= 1 mSv/y. The dose is assumed to be measurable with the surveymeter (1 cm dose equivalent) and thereby calculation, if the source is mainly "1"3"4Cs and "1"3"7Cs, gives the effective dose of 0.32 mc-Sv/hr to be managed by the meter. As this, the effective dose unit and 1 cm equivalent dose unit are used for calculation of the administrative standard dose rate of 1 mSv/y, which should be recognized by both radiological experts and administration for the explanation to general public. (T.T.)

Change of offices for HR Department - disrupted service during the last week of February 2013

CERN Multimedia

2013-01-01

HR Department would like to inform that, due to office renovation work, a number of HR Services currently located on the ground, first and second floors of Building 5 will move to temporary offices as from late February.   The removals will take place from Friday 22 until Tuesday 26 February 2013 inclusive and during this period, telephone and e-mail contact may be disrupted. The following services will be relocated to: Building 510  – ground floor (until mid-June) Head of Department and Deputy Office of the Head of HR Department Group Leaders and Partners Diversity Office HR Legal Section Building 652 – Prefab/Algeco (until September) Human Resources Advisors and assistants Staff Recruitment Service Fellows & Apprentices Service Students & Associates Service Temporary office numbers will be available in the CERN phonebook. Any emergencies during the removals may be addressed to Lynda.Leroux@cern.ch Thank you in advance for your understanding. HR Head O...

PENGEMBANGAN PERSAMAAN VO2 MAX DAN EVALUASI HR MAX (STUDI AWAL PADA PEKERJA PRIA

Directory of Open Access Journals (Sweden)

Purnawan Adi Wicaksono

2012-10-01

Full Text Available Kapasitas fisik maksimum seseorang direpresentasikan dengan nilai konsumsi oksigen maksimum (VO2 Max dan denyut nadi maksimum (HR Max yang memberikan suatu informasi batasan kemampuan fisik maksimum seseorang dalam melakukan pekerjaan. Penelitian kali ini mempunyai tujuan untuk mencari nilai VO2 Max pekerja pria Indonesia untuk nantinya akan dikembangkan suatu persamaan prediksi VO2 Max yang didekati dengan hubungan linier antara denyut nadi (Heart Rate seperti yang dilakukan Astrand (2003, tinggi badan (Chatterjee et al, 2006, berat badan (Akalan et al, 2008, usia (Magrani et al, 2009 dan mengevaluasi persamaan HR Max manakah yang dapat diaplikasikan untuk mendekati nilai denyut nadi maksimum pekerja Indonesia. Responden dalam penelitian kali ini adalah 12  pekerja industri pria yang diambil dari beberapa industri di Depok dan sekitarnya. Kriteria responden yang berpartisipasi dalam penelitian kali ini adalah: berusia 20-40 tahun, bukan perokok baik aktif maupun pasif, sehat , tidak mengkonsumsi makanan, kafein, alkohol minimal 2 jam sebelum eksperimen (Balderrama et. al, 2007.Eksperimen yang dilakukan menggunakan metode maximal test dengan protokol treadmill. Adapun peralatan yang digunakan adalah seperangkat alat pengukur kondisi fisiologi Fitmate MED (COSMED srl-Italy terdiri dari Heart Rate Transmitter, Heart Rate Receiver, V mask (Hans Rudolph Inc,dan treadmill SportArt@60.  Eksperimen dilakukan menjadi dua bagian, yaitu istirahat dan tahap bekerja.Aktivitas istirahat terdiri dari tidur selama 20 menit, duduk selama 20 menit dan berdiri selama 10 menit. Eksperimen tahap kedua yaitu tahap kerja yang terdiri dari latihan selama 5 menit. Responden dipersilakan beristirahat selama 15 menit, setelah itu responden melaksanakan maximal test detik hingga responden merasa tidak sanggup lagi melanjutkan eksperimen. Hasil penelitian model prediksi VO2 max untuk pekerja industri pria mempunyai nilai 2,78 ± 0,5 liter/menit dan dengan regresi linier

Elimination of C3 as the Bond-Neff depression opacity source in Hr 774

International Nuclear Information System (INIS)

Baird, S.R.

1982-01-01

The pseudocontinuum of C 3 has been proposed by Fix as the source of the Bond-Neff depression in HR 774. In such a case the strongest rotational lines of the 4050 A vibrational band of C 3 should be clearly evident at high dispersion. A 2.2 A mm -1 plate of HR 774 is examined in the 4050--4060 A region where the strongest lines should form. The absence of C 3 rotational lines indicates that C 3 cannot be the major contributor to the Bond-Neff depression in HR 774

Risk management is every managers’ responsibility: Are HR practitioners ready for the challenge

Directory of Open Access Journals (Sweden)

Pascal Siphelele Zulu

2014-07-01

Full Text Available Risk and Enterprise Risk Management has become a strategic imperative in most organisations and government departments over the years. Most company boards and government entities in South Africa have adopted various corporate governance frameworks as a mechanism to direct and control the operations of their organisations. As a result, risk management and enterprise risk management has become every manager’s responsibility. The key question that the study investigates is whether HR managers are aware of this strategic imperative and ready to be risk champions in their environment. Data was collected from forty eight (48 HR Managers and Practitioners from private companies and sixty eight (68 HR Managers and Practitioners from government departments and government companies in Durban, Kwazulu-Natal and Cape Town, Western Cape using both personal interviews and questionnaires which were distributed to one hundred and fifty (150 employees, of which one hundred and sixteen (116 questionnaires were completed (return rate 77.3%. The results of this paper indicate that, in general and across all sectors, HR practitioners’ levels of understanding of corporate governance and risk management is limited

Réunion publique HR

CERN Multimedia

CERN. Geneva

2010-01-01

Chers Collègues,Je me permets de vous rappeler qu'une réunion publique organisée par le Département HR se tiendra aujourd'hui:Vendredi 30 avril 2010 à 9h30 dans l'Amphithéâtre principal (café offert dès 9h00).Durant cette réunion, des informations générales seront données sur:le CERN Admin e-guide, qui est un nouveau guide des procédures administratives du CERN ayant pour but de faciliter la recherche d'informations pratiques et d'offrir un format de lecture convivial;le régime d'Assurance Maladie de l'Organisation (présentation effectuée par Philippe Charpentier, Président du CHIS Board) et;la Caisse de Pensions (présentation effectuée par Théodore Economou, Administrateur de la Caisse de Pensions du CERN).Une transmission simultanée de cette réunion sera assur...

Synthetic H-R diagrams as an observational test of stellar evolution theory

International Nuclear Information System (INIS)

Mathews, G.J.; Becker, S.A.; Brunish, W.M.

1983-07-01

Synthetic H-R diagrams are constructed from a grid of stellar models. These are compared directly with observations of young clusters in the LMC and SMC as a test of the models and as a means to determine the age, age dispersion, and composition of the clusters. Significant discrepancies between the observed and model H-R diagrams indicate the possible influences of convective overshoot, large AGB mass-loss rates, and the best value for the mixing length parameter

Exploring high-resolution magic angle spinning (HR-MAS) NMR spectroscopy for metabonomic analysis of apples.

Science.gov (United States)

Vermathen, Martina; Marzorati, Mattia; Vermathen, Peter

2012-01-01

Classical liquid-state high-resolution (HR) NMR spectroscopy has proved a powerful tool in the metabonomic analysis of liquid food samples like fruit juices. In this paper the application of (1)H high-resolution magic angle spinning (HR-MAS) NMR spectroscopy to apple tissue is presented probing its potential for metabonomic studies. The (1)H HR-MAS NMR spectra are discussed in terms of the chemical composition of apple tissue and compared to liquid-state NMR spectra of apple juice. Differences indicate that specific metabolic changes are induced by juice preparation. The feasibility of HR-MAS NMR-based multivariate analysis is demonstrated by a study distinguishing three different apple cultivars by principal component analysis (PCA). Preliminary results are shown from subsequent studies comparing three different cultivation methods by means of PCA and partial least squares discriminant analysis (PLS-DA) of the HR-MAS NMR data. The compounds responsible for discriminating organically grown apples are discussed. Finally, an outlook of our ongoing work is given including a longitudinal study on apples.

In-sourcing HR: shared service centres in the Netherlands

NARCIS (Netherlands)

Farndale, Elaine; Paauwe, Jaap; Hoeksema, Ludwig

2009-01-01

Due to the impact of now widely-available technologies, new logics behind the organisation of the HR function through the in- and outsourcing of HRM activities have been emerging, particularly addressing issues of integration, cost-efficiency and competitive advantage. In particular, increasing

Stimulating teachers’ team performance through team-oriented HR practices

NARCIS (Netherlands)

Bouwmans, Machiel; Runhaar, Piety; Wesselink, Renate; Mulder, Martin

2017-01-01

Teams of teachers are increasingly held accountable for the quality of education and educational reforms in vocational education and training institutions. However, historically teachers have not been required to engage in deep-level collaboration, thus team-oriented HR practices are being used

HR strategy – necessity or fad for business sustainability?

Directory of Open Access Journals (Sweden)

Ghinea Valentina Mihaela

2016-07-01

Full Text Available The present paper pleads for the awareness of HR strategy importance, in terms of proper design and implementation, as they definitely could impede or sustain the development of an organization. By making use of G.VALI, the model of organizational culture dynamics, we look for revealing the impact that (non-existence of HR strategy, its alignment and coherence could have on the organization success. As proven by human experience, all types of strategies could work and be effective in certain conditions. Even more, no one can say that one strategy is better than other. However, in the same way, there is no guarantee of some strategies success. In this light, the difference lays in the handy and clever interlock of the country specific advantages and firm (-tobe specific advantages. For achieving this specific aim, vertical (alignment and horizontal (coherence integration of each functional strategy must be ensured.

HR 8844: A New Transition Object between the Am Stars and the HgMn Stars?

Science.gov (United States)

Monier, R.; Gebran, M.; Royer, F.; Kilicoglu, T.; Frémat, Y.

2018-02-01

While monitoring a sample of apparently slowly rotating superficially normal early-A stars, we have discovered that HR 8844 (A0 V) is actually a new chemically peculiar star. We first compared the high-resolution spectrum of HR 8844 with that of four slow rotators near A0V (ν Cap, ν Cnc, Sirius A, and HD 72660) to highlight similarities and differences. The lines of Ti II, Cr II, Sr II, and Ba II are conspicuous features in the high-resolution high signal-to-noise SOPHIE spectra of HR 8844 and much stronger than in the spectra of the normal star ν Cap. The Hg II line at 3983.93 Å is also present in a 3.5% blend. Selected unblended lines of 31 chemical elements from He up to Hg have been synthesized using model atmospheres computed with ATLAS9 and the spectrum synthesis code SYNSPEC48 including hyperfine structure of various isotopes when relevant. These synthetic spectra have been adjusted to the mean SOPHIE spectrum of HR 8844, and high-resolution spectra of the comparison stars. Chi-squares were minimized to derive abundances or upper limits to the abundances of these elements for HR 8844 and the comparison stars. HR 8844 is found to have underabundances of He, C, O, Mg, Ca, and Sc, mild enhancements of Ti, V, Cr, Mn, and distinct enhancements of the heavy elements Sr, Y, Zr, Ba, La, Pr, Sm, Eu, and Hg, the overabundances increasing steadily with atomic number. This chemical pattern suggests that HR 8844 may actually be a new transition object between the coolest HgMn stars and the Am stars.

Human Resource Predictive Analytics HRPA For HR Management In Organizations

Directory of Open Access Journals (Sweden)

Sujeet N. Mishra

2015-08-01

Full Text Available Human resource predictive analytics is an evolving application field of analytics for HRM purposes. The purpose of HRM is measuring employee performance and engagement studying workforce collaboration patterns analyzing employee churn and turnover and modelling employee lifetime value. The motive of applying HRPA is to optimize performances and produce better return on investment for organizations through decision making based on data collection HR metrics and predictive models. The paper is divided into three sections to understand the emergence of HR predictive analytics for HRM. Firstly the paper introduces the concept of HRPA. Secondly the paper discusses three aspects of HRPA a Need b Approach amp Application c Impact. Lastly the paper leads to the conclusion on HRPA.

THE CHANGING ROLE OF HR: VALUES AND CONTRIBUTION

DEFF Research Database (Denmark)

Andersen, Torben; Krogager, Per

2011-01-01

This paper illustrates, through a case-study of one of the old life sciences and diagnostics companies in Denmark, Radiometer Medical Plc. (now part of the Danaher Corporation), how the HR-department starts to work in a much more systematic way with effectiveness and efficiency, in the attempt...... with a stronger emphasis on core values and rationalizing the function itself....

RESTORATION TECHNIQUE FOR PLEIADES-HR PANCHROMATIC IMAGES

Directory of Open Access Journals (Sweden)

C. Latry

2012-07-01

Full Text Available 17th of December 2011 from Kourou Space Centre, French Guyana. Like others high resolution optical satellites, it acquires both panchromatic images, with 70cm spatial resolution, and lower resolution multispectral images with 2.8m spatial resolution. Pleiades-HR is an optimized system, which means that the Modulation Transfer Function has a low value at Nyquist frequency, in order to reduce both the telescope diameter and aliasing effects. Shannon sampling condition is thus met at first order, which also makes classical ground processing, such as image matching or resampling, more justified for a mathematical point of view. Raw images are thus blurry which implies a deconvolution stage that restores sharpness but also increases the noise level in the high frequency domain. A denoising step, based upon wavelet packet coefficients thresholding/shrinkage technique, allows controlling the final noise level. Each of these methods includes numerous parameters that have to be assessed during the inflight commissioning period: deconvolution filter that depends on MTF assessment, instrumental noise model, noise level target for denoised images, wavelet packet decomposition level. This paper aims to precisely describe the deconvolution/denoising algorithms and how their main parameters have been set up during the inflight commissioning stage. Special attention will be given to structured noise induced by Pleiades-HR on board wavelet-based compression algorithm

HPV test by Hybrid Capture II for the diagnosis of HR-HPV persistent infection.

Science.gov (United States)

Serour, Y; Bendahmane, M; Abbou Baker, F; Medles, M; Moueddene, B; Kraiba, R

2017-11-01

Persistent high-risk HPV (HR-HPV) infection is associated with a greater risk of cervical cancer. Statistical data on the prevalence of HR-HPV infections in the Algerian population is lacking. We conducted a prospective study of 300 women aged between 25 and 50 years, screened for cervical cancer from 2012 to 2015 in Sidi Bel Abbès, a western region of Algeria. We aimed to assess the reliability of the repeated use of the HC II test (three longitudinal HPV tests 9 months apart from each other) in diagnosing the persistence of HR-HPV infection. The prevalence of HR-HPV infection was 7.33% and infected women were aged 37.9±3years. For 90.9% of HR-HPV-positive patients, the infection persisted for a mean of 18.5months [95% CI: 16.9-22.1months]. Among these patients, 55.55% developed CIN1 and 11.11% developed CIN2. The sensitivity of the HC II test was 81.74% [95% CI: 71.3-89.6] and its positive predictive value associated with abnormal cervical biopsy was 27.49% [95% CI: 16.0-33.33]. Repeating the HC II test is a good predictor for identifying women at high risk of cervical cancer. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

From Admin to Strategy: The Changing Face of the HR Function. IES Report 332.

Science.gov (United States)

Tamkin, Penny; And Others

Evidence from academic research and management experts in the United Kingdom and elsewhere confirms that the recent focus in work organizations on cost reductions through downsizing has changed the roles and structures of many human resources (HR) units. HR units have had to prove their contribution to the organization's bottom line, raise their…

DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a

Science.gov (United States)

Walters, Kylie J.; Lech, Patrycja J.; Goh, Amanda M.; Wang, Qinghua; Howley, Peter M.

2003-01-01

The Rad23 family of proteins, including the human homologs hHR23a and hHR23b, stimulates nucleotide excision repair and has been shown to provide a novel link between proteasome-mediated protein degradation and DNA repair. In this work, we illustrate how the proteasomal subunit S5a regulates hHR23a protein structure. By using NMR spectroscopy, we have elucidated the structure and dynamic properties of the 40-kDa hHR23a protein and show it to contain four structured domains connected by flexible linker regions. In addition, we reveal that these domains interact in an intramolecular fashion, and by using residual dipolar coupling data in combination with chemical shift perturbation analysis, we present the hHR23a structure. By itself, hHR23a adopts a closed conformation defined by the interaction of an N-terminal ubiquitin-like domain with two ubiquitin-associated domains. Interestingly, binding of the proteasomal subunit S5a disrupts the hHR23a interdomain interactions and thereby causes it to adopt an opened conformation. PMID:14557549

Acute effects of Cu on oxygen consumption and 96 hr-LC 50 values ...

African Journals Online (AJOL)

The median lethal copper (Cu) concentration (96 hr-LC50) values for acute Cu toxicity for Tilapia sparrmanii (live mass: 30 ± 8g) in Mooi River hard water of dolomitic origin at 20° C, pH 7.9, was 68.1 µmol l–1. At this 96 hr-LC50 value the specific oxygen consumption rate (∉ O2) decreased by 44.2 (± 2.1) % from a ...

Deep thermal infrared imaging of HR 8799 bcde: new atmospheric constraints and limits on a fifth planet

Energy Technology Data Exchange (ETDEWEB)

Currie, Thayne; Cloutier, Ryan; Jayawardhana, Ray [Department of Astronomy and Astrophysics, University of Toronto, 50 St. George Street, Toronto, ON M5S 3H4 (Canada); Burrows, Adam [Department of Astrophysical Science, Princeton University, 4 Ivy Lane, Princeton, NJ 08544 (United States); Girard, Julien H. [European Southern Observatory, Alonso de Córdova 3107, Vitacura, Casilla 19001, Santiago (Chile); Fukagawa, Misato [Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka 560-0043 (Japan); Sorahana, Satoko [Department of Astronomy, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033 (Japan); Kuchner, Marc [Exoplanets and Stellar Astrophysics Laboratory, NASA Goddard Space Flight Center, Code 667, Greenbelt, MD 20771 (United States); Kenyon, Scott J. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Madhusudhan, Nikku [Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA (United Kingdom); Itoh, Yoichi [Nishi-Harima Astronomical Observatory, Center for Astronomy, University of Hyago, 407-2 Nishigaichi, Sayo, Hyogo 679-5313 (Japan); Matsumura, Soko [School of Engineering, Physics, and Mathematics, University of Dundee, Dundee DD1 4HN (United Kingdom); Pyo, Tae-Soo [National Astronomical Observatory of Japan, 650 N. Aohoku Place, Hilo, HI 96720 (United States)

2014-11-10

We present new L' (3.8 μm) and Brα (4.05 μm) data and reprocessed archival L' data for the young, planet-hosting star HR 8799 obtained with Keck/NIRC2, VLT/NaCo, and Subaru/IRCS. We detect all four HR 8799 planets in each data set at a moderate to high signal-to-noise ratio (S/N ≳ 6-15). We fail to identify a fifth planet, 'HR 8799 f', at r < 15 AU at a 5σ confidence level: one suggestive, marginally significant residual at 0.''2 is most likely a point-spread function artifact. Assuming companion ages of 30 Myr and the Baraffe planet cooling models, we rule out an HR 8799 f with a mass of 5 M{sub J} (7 M{sub J} ), 7 M{sub J} (10 M{sub J} ), or 12 M{sub J} (13 M{sub J} ) at r {sub proj} ∼ 12 AU, 9 AU, and 5 AU, respectively. All four HR 8799 planets have red early T dwarf-like L' – [4.05] colors, suggesting that their spectral energy distributions peak in between the L' and M' broadband filters. We find no statistically significant difference in HR 8799 cde's color. Atmosphere models assuming thick, patchy clouds appear to better match HR 8799 bcde's photometry than models assuming a uniform cloud layer. While non-equilibrium carbon chemistry is required to explain HR 8799 b and c's photometry/spectra, evidence for it from HR 8799 d and e's photometry is weaker. Future, deep-IR spectroscopy/spectrophotometry with the Gemini Planet Imager, SCExAO/CHARIS, and other facilities may clarify whether the planets are chemically similar or heterogeneous.

Deep thermal infrared imaging of HR 8799 bcde: new atmospheric constraints and limits on a fifth planet

International Nuclear Information System (INIS)

Currie, Thayne; Cloutier, Ryan; Jayawardhana, Ray; Burrows, Adam; Girard, Julien H.; Fukagawa, Misato; Sorahana, Satoko; Kuchner, Marc; Kenyon, Scott J.; Madhusudhan, Nikku; Itoh, Yoichi; Matsumura, Soko; Pyo, Tae-Soo

2014-01-01

We present new L' (3.8 μm) and Brα (4.05 μm) data and reprocessed archival L' data for the young, planet-hosting star HR 8799 obtained with Keck/NIRC2, VLT/NaCo, and Subaru/IRCS. We detect all four HR 8799 planets in each data set at a moderate to high signal-to-noise ratio (S/N ≳ 6-15). We fail to identify a fifth planet, 'HR 8799 f', at r < 15 AU at a 5σ confidence level: one suggestive, marginally significant residual at 0.''2 is most likely a point-spread function artifact. Assuming companion ages of 30 Myr and the Baraffe planet cooling models, we rule out an HR 8799 f with a mass of 5 M J (7 M J ), 7 M J (10 M J ), or 12 M J (13 M J ) at r proj ∼ 12 AU, 9 AU, and 5 AU, respectively. All four HR 8799 planets have red early T dwarf-like L' – [4.05] colors, suggesting that their spectral energy distributions peak in between the L' and M' broadband filters. We find no statistically significant difference in HR 8799 cde's color. Atmosphere models assuming thick, patchy clouds appear to better match HR 8799 bcde's photometry than models assuming a uniform cloud layer. While non-equilibrium carbon chemistry is required to explain HR 8799 b and c's photometry/spectra, evidence for it from HR 8799 d and e's photometry is weaker. Future, deep-IR spectroscopy/spectrophotometry with the Gemini Planet Imager, SCExAO/CHARIS, and other facilities may clarify whether the planets are chemically similar or heterogeneous.

Linking educational leadership styles to the HR architecture for new teachers in primary education.

Science.gov (United States)

Vekeman, Eva; Devos, Geert; Valcke, Martin

2016-01-01

This study aims to gain insight in the relationship between principals' leadership styles and the configuration of different HR practices for new teachers in primary education. Besides the longstanding interest in educational leadership as a key element in teacher and student performance, there is a growing interest in strategic human resource management (SHRM) in the educational sector. However, few educational studies link educational leadership to SHRM. In particular, this study examines the relationship between principals' instructional and transformational leadership style and principals' strategic and HR orientation in configuring HR practices for new teachers. Data were gathered using a mixed methods approach, including interviews with 75 principals as well as an online survey of 1058 teachers in Flemish primary education. Qualitative interview data were transformed and analysed together with the quantitative survey data using logistic regression and ANOVA analyses. The results indicate that both instructional and transformational leadership is associated with the strategic orientation of principals. The HR orientation, on the other hand, is not reflected in the principals' leadership style. Recommendations for further research in this area are discussed.

Value-based HR practices, i-deals and clinical error control with CSR as a moderator.

Science.gov (United States)

Luu, Tuan; Rowley, Chris; Siengthai, Sununta; Thanh Thao, Vo

2017-05-08

Purpose Notwithstanding the rising magnitude of system factors in patient safety improvement, "human factors" such as idiosyncratic deals (i-deals) which also contribute to the adjustment of system deficiencies should not be neglected. The purpose of this paper is to investigate the role of value-based HR practices in catalyzing i-deals, which then influence clinical error control. The research further examines the moderating role of corporate social responsibility (CSR) on the effect of value-based HR practices on i-deals. Design/methodology/approach The data were collected from middle-level clinicians from hospitals in the Vietnam context. Findings The research results confirmed the effect chain from value-based HR practices through i-deals to clinical error control with CSR as a moderator. Originality/value The HRM literature is expanded through enlisting i-deals and clinical error control as the outcomes of HR practices.

EXCEPTIONAL CLOSURE OF VARIOUS HR DEPARTEMENT SERVICES ON 20 AND 21 SEPTEMBER 2007

CERN Document Server

HR Department

2007-01-01

Due to a group training event, the following services will be exceptionally closed on Thursday 20 and Friday 21 September 2007 : installation service (removals, cars, diplomatic privileges), school fees, Personnel Records Office (including attestations), French visas; duty travel, leave, reinstallation indemnity, unemployment benefit, tax information and social affairs. The French and Swiss cards service will remain open as usual, from 8:30 to 12:30. Thank you for your understanding. HR Department HR-SPS Group

EXCEPTIONAL CLOSURE OF VARIOUS HR DEPARTMENT SERVICES ON 20 AND 21 SEPTEMBER 2007

CERN Document Server

*Beyond was established as CIC Productions to produce the television series Beyond 2000 for the Seven Network in Australia,

2007-01-01

Due to a group training event, the following services will be exceptionally closed on Thursday 20 and Friday 21 September 2007: installation service (removals, cars, diplomatic privileges), school fees, Personnel Records Office (including attestations), French visas; duty travel, leave, reinstallation indemnity, unemployment benefit, tax information and social affairs. The French and Swiss cards service will remain open as usual, from 8:30 to 12:30. Thank you for your understanding. HR Department HR-SPS Group

Understanding the effectiveness of precursor reductions in lowering 8-hr ozone concentrations--Part II. The eastern United States.

Science.gov (United States)

Reynolds, Steven D; Blanchard, Charles L; Ziman, Stephen D

2004-11-01

Analyses of ozone (O3) measurements in conjunction with photochemical modeling were used to assess the feasibility of attaining the federal 8-hr O3 standard in the eastern United States. Various combinations of volatile organic compound (VOC) and oxides of nitrogen (NOx) emission reductions were effective in lowering modeled peak 1-hr O3 concentrations. VOC emissions reductions alone had only a modest impact on modeled peak 8-hr O3 concentrations. Anthropogenic NOx emissions reductions of 46-86% of 1996 base case values were needed to reach the level of the 8-hr standard in some areas. As NOx emissions are reduced, O3 production efficiency increases, which accounts for the less than proportional response of calculated 8-hr O3 levels. Such increases in O3 production efficiency also were noted in previous modeling work for central California. O3 production in some urban core areas, such as New York City and Chicago, IL, was found to be VOC-limited. In these areas, moderate NOx emissions reductions may be accompanied by increases in peak 8-hr O3 levels. The findings help to explain differences in historical trends in 1- and 8-hr O3 levels and have serious implications for the feasibility of attaining the 8-hr O3 standard in several areas of the eastern United States.

Limited field investigation report for the 100-HR-2 Operable Unit

International Nuclear Information System (INIS)

1994-09-01

This report summarizes the data collection and analysis activities conducted during the 100-HR-2 Operable Unit investigative phase and the associated qualitative risk assessment (QRA). The 100-HR-2 Operable Unit contains solid waste burial grounds, an ash pit, bum pits, electrical facilities, septic systems, and support facilities. All known and suspected areas of contamination were classified as solid waste burial grounds or low-priority waste sites based on the collective knowledge of the operable unit managers (representatives from the US Department of Energy [DOE], the US Environmental Protection Agency [EPA], and Washington Department of Ecology [Ecology]) during the preparation of the 100-HR-2 Operable Unit work plan (DOE/RL 1993f). Solid waste burial grounds were judged to pose sufficient risk(s), through one or more pathways, to require evaluation for an interim remedial measure (IRM) as per the Hanford Past-Practice Strategy (HPPS) (DOE/RL 1991) and negotiations with DOE, EPA, and Ecology. An IRM is intended to achieve remedies that are likely to lead to a final record of decision. Low-priority sites are those judged not to pose significant risk to require the streamlined evaluation. There were six low-priority waste sites and seven solid waste burial grounds identified. The investigative phase was conducted in accordance with the RCRA Facility Investigation/Corrective Measures Study Work Plan for the 100-HR-2 Operable Unit (DOE/RL 1993f). The QRA was performed in accordance with the Hanford Site Baseline Risk Assessment Methodology (DOE/RL 1993b) and the recommendations incorporate the strategies of the HPPS. The purpose of this report is to: (1) provide a summary of site investigative activities; (2) refine the conceptual exposure model (as needed); (3) identify chemical- and location-specific corrective action requirements; and (4) provide a human health and ecological QRA associated with solid waste burial grounds

Implementation HR information system – part of a unified information environment of MPEI

Directory of Open Access Journals (Sweden)

I. M. Krepkov

2016-01-01

Full Text Available The article is devoted to the unified information environment of National Research University “Moscow Power Engineering Institute” (MPEI, and its most important component – the HR information system. The article describes the architecture of the unified information space of MPEI. The main objective of the development of the HR information system – to provide access to users, including other information systems, to actual information about employees of MPEI.HR information system are based on many years of operating experience of the previous system and the like, are available on the market today, taking into account the decisions of personnel. The earlier HR information system was developed in 1995–1997 and used until mid-2015. In the process of its using it has accumulated a large number of «patches» and requests for revision that was stopped by limitations in the platform and solutions architecture. Comparative analysis of 1C and SAP products showed that the cost of implementation, configuration and maintenance of these products is higher than developing new solutions. Package of Microsoft technology software was chosen as a platform. These technologies have proven themselves in the development of similar projects, and vendor solutions for a long time support all key processes of information systems. Important is the presence of the selected software Microsoft FSTEC certificates (Federal Service for Technical and Export Control, which support the use of these products for storing and processing information in accordance with the laws of the Russian Federation. The MPEI has already implemented a number of systems on the Microsoft platform – postgraduate register, an Internet portal, etc. The use of technology of one supplier facilitates the integration processes and products into a unified information environment. The article details the technical and hardware specifications of the HR information system. The result of the work on

How the impact of HR practices on employee well-being and performance changes with age

NARCIS (Netherlands)

Kooij, T.A.M.; Guest, D.; Clinton, M.; Knight, T.; Jansen, P.G.W.; Dikkers, J.S.E.

2013-01-01

With changing retirement ages and an aging workforce, interest is growing on the potential contribution of relevant bundles of HR practices in eliciting well-being and performance among aging workers. Drawing on theories on lifespan development and self-regulation, we distinguished two bundles of HR

How the impact of HR Practices on employee well-being and performance changes with age

NARCIS (Netherlands)

Kooij, T.A.M.; Guest, D.; Clinton, M.; Knight, T.; Jansen, P.G.W.; Dikkers, J.S.E.

2013-01-01

With changing retirement ages and an aging workforce, interest is growing on the potential contribution of relevant bundles of HR practices in eliciting well-being and performance among aging workers. Drawing on theories on lifespan development and self-regulation, we distinguished two bundles of HR

[THE FIRST EPIDEMIOLOGICAL DATA ABOUT THE HR-HUMAN PAPILLOMA VIRUS TYPES IN SOUTH AND NORTHERN BULGARIA].

Science.gov (United States)

Kovachev, S; Slavov, V; Slavova, K; Ganovska, A

2015-01-01

The aim of our study were to evaluate the prevalence of HR-HPV infection in women between 15 and 55 years of age in the South and Northern Bulgaria. We have analyzed the HPV status (using DNA-sorb-AM nucleic acid extraction kit) in cervical samples collected during a 3 year period (2010-2012) from 1020 women, aged 15-55 and divided in four age groups, who attended their gynecologists for HPV-DNA cervical test. The rate of the HR-HPV infection was established to be 39.9%. HR-HPV negative were 60.1% of the evaluated subjects. The most commonly isolated genotype in all 407 (100%) infected women was HPV 16 - 190 women (46.7%), followed by HPV 56 - 78 (19.1%), HPV 31- 48 (11.8%) and HPV 33 - 45 (11.1%). To our knowledge, this is the first survey evaluating the prevalence of HR-HPV infection in the South and Northern regions of Bulgarian towns and drawing attention to the unusually high proportion of different HR-HPV.

A Qualitative Study of HR/OHS Stress Interventions in Australian Universities

Science.gov (United States)

Winefield, Anthony H.; Boyd, Carolyn M.

2018-01-01

To enhance the understanding of psychosocial factors and extend research on work stress interventions, we investigated the key human resource (HR)/occupational health and safety (OHS) stress interventions implemented at five Australian universities over a three-year period. Five senior HR Directors completed an online survey to identify the intervention strategies taken at their university in order to reduce stress and enhance employee well-being and morale. We also explored the types of individual-, organization-, and individual/organization-directed interventions that were implemented, and the strategies that were prioritized at each university. Across universities, the dominant interventions were strategies that aimed to balance the social exchange in the work contract between employee-organization with an emphasis on initiatives to: enhance training, career development and promotional opportunities; improve remuneration and recognition practices; and to enhance the fairness of organizational policies and procedures. Strategies to improve work-life balance were also prominent. The interventions implemented were predominantly proactive (primary) strategies focused at the organizational level and aimed at eliminating or reducing or altering work stressors. The findings contribute to the improved management of people at work by identifying university-specific HR/OHS initiatives, specifically leadership development and management skills programs which were identified as priorities at three universities. PMID:29315278

A Qualitative Study of HR/OHS Stress Interventions in Australian Universities.

Science.gov (United States)

Pignata, Silvia; Winefield, Anthony H; Boyd, Carolyn M; Provis, Chris

2018-01-09

To enhance the understanding of psychosocial factors and extend research on work stress interventions, we investigated the key human resource (HR)/occupational health and safety (OHS) stress interventions implemented at five Australian universities over a three-year period. Five senior HR Directors completed an online survey to identify the intervention strategies taken at their university in order to reduce stress and enhance employee well-being and morale. We also explored the types of individual-, organization-, and individual/organization-directed interventions that were implemented, and the strategies that were prioritized at each university. Across universities, the dominant interventions were strategies that aimed to balance the social exchange in the work contract between employee-organization with an emphasis on initiatives to: enhance training, career development and promotional opportunities; improve remuneration and recognition practices; and to enhance the fairness of organizational policies and procedures. Strategies to improve work-life balance were also prominent. The interventions implemented were predominantly proactive (primary) strategies focused at the organizational level and aimed at eliminating or reducing or altering work stressors. The findings contribute to the improved management of people at work by identifying university-specific HR/OHS initiatives, specifically leadership development and management skills programs which were identified as priorities at three universities.

A Qualitative Study of HR/OHS Stress Interventions in Australian Universities

Directory of Open Access Journals (Sweden)

Silvia Pignata

2018-01-01

Full Text Available To enhance the understanding of psychosocial factors and extend research on work stress interventions, we investigated the key human resource (HR/occupational health and safety (OHS stress interventions implemented at five Australian universities over a three-year period. Five senior HR Directors completed an online survey to identify the intervention strategies taken at their university in order to reduce stress and enhance employee well-being and morale. We also explored the types of individual-, organization-, and individual/organization-directed interventions that were implemented, and the strategies that were prioritized at each university. Across universities, the dominant interventions were strategies that aimed to balance the social exchange in the work contract between employee-organization with an emphasis on initiatives to: enhance training, career development and promotional opportunities; improve remuneration and recognition practices; and to enhance the fairness of organizational policies and procedures. Strategies to improve work-life balance were also prominent. The interventions implemented were predominantly proactive (primary strategies focused at the organizational level and aimed at eliminating or reducing or altering work stressors. The findings contribute to the improved management of people at work by identifying university-specific HR/OHS initiatives, specifically leadership development and management skills programs which were identified as priorities at three universities.

Direct detection and orbital analysis of the exoplanets HR 8799 bcd from archival 2005 Keck/NIRC2 data

NARCIS (Netherlands)

Currie, T.; Fukagawa, M.; Thalmann, C.; Matsumura, S.; Plavchan, P.

2012-01-01

We present previously unpublished 2005 July H-band coronagraphic data of the young, planet-hosting star HR 8799 from the newly released Keck/NIRC2 archive. Despite poor observing conditions, we detect three of the planets (HR 8799 bcd), two of them (HR 8799 bc) without advanced image processing.

100-HR-2 Operable Unit Focused Feasibility study report

International Nuclear Information System (INIS)

1995-01-01

The standard Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) Feasibility Study (FS) includes development and screening of alternatives (Phases 1 and 2) and the detailed analysis of alternatives (Phase 3). This focused feasibility study (FFS) was conducted for the 100-HR-2 Operable Unit (OU) at the Hanford Site in southeastern Washington. This FFS constitutes the Phase 3 portion of the FS process for the remedial alternatives initially developed and screened in the 100 Area Feasibility Study Phases 1 and 2 (DOE-RL 1993a). The objective of this OU-specific FFS is to provide decision makers with sufficient information to allow appropriate and timely selection of interim remedial measures (IRM) for the seven IRM candidate sites associated with the 100-HR-2 OU. The IRM candidate waste sites identified in Table ES-1 are determined in the limited field investigation (DOE-RL 1994b). Site profiles are developed for each of these waste sites. The site profiles are used in the application of the plug-in approach. The waste site either plugs into the analysis of the alternatives for the group, or deviations from the developed group alternatives are described and documented. A summary for the 100-HR-2 IRM candidate waste site is as follows: none of the waste sites require additional alternative development. six of the seven waste sites directly plug into the waste site group alternatives. The site-specific detailed analysis is conducted, referencing the waste site group analysis as appropriate. A waste site detailed analysis summary is presented in Table ES-1.A comparative analysis of remedial alternatives is presented for each waste site. A summary of the comparative analysis is presented in Table ES-2

Next HR Department Public meeting

CERN Multimedia

2012-01-01

  Dear Colleagues, I am pleased to invite you to the next public meeting organized by HR Department, which will take place on Monday 25 June at 14:30, for the first time in the Globe (in front of the Reception). The agenda will comprise of: ·         the recent staff member survey results ·         the Diversity at CERN ·         the Learning and Development Policy The first topic concerns, more specifically, staff members. All presentations will be made in English, however, we are pleased to inform you that a simultaneous interpretation in French is foreseen. Should you not be able to attend the meeting, it can also be followed via Webcast and the recording will be made available on Indico. Finally, subject to a favourable weather, refreshments...

Reducing employees’ turnover intention through Hr-induced organizational citizenship behaviour: Leader-member exchange as the mediator

Directory of Open Access Journals (Sweden)

YU GHEE WEE

2013-07-01

Full Text Available This study examines the possibility of inducing organizational citizenship behavior (OCB through human resource (HR philosophy and high involvement HR practices administered at the workplace. Leader-member exchange (LMX, a basis of relational infrastructure, is posited to be a potential mediator. Data was collected from hotel frontline employees, tested and analyzed through structural equation modeling. Findings show that HR philosophy drives the formulation of the bundles of high involvement human resource practices and such philosophy contribute to employees’ willingness in exhibiting organizational citizenship behavior (OCB directed at individuals (OCBI as well as organizations (OCBO as a whole. High involvement HR practices, however, do not elicit OCB but these practices are significantly related to LMX, a new theoretical insight which should invite future research. Although exchanges between supervisors and subordinates are shown to have influences on employees’ willingness in performing OCB, LMX does not, however, mediate the relationship between high involvement HR practices and OCB. Overall, hotel frontline employees participated in this study exhibit more OCBO, rather than OCBI; and such behavior reduce their intention to leave. Both theoretical and practical implications as well as avenues for future research are discussed.

High-Risk Human Papillomavirus (hrHPV) E6/E7 mRNA Testing by PreTect HPV-Proofer for Detection of Cervical High-Grade Intraepithelial Neoplasia and Cancer among hrHPV DNA-Positive Women with Normal Cytology

Science.gov (United States)

Rijkaart, D. C.; Heideman, D. A. M.; Coupe, V. M. H.; Brink, A. A. T. P.; Verheijen, R. H. M.; Skomedal, H.; Karlsen, F.; Morland, E.; Snijders, P. J. F.

2012-01-01

Our aim was to investigate whether high-risk HPV (hrHPV) mRNA detection by PreTect HPV-Proofer can be used to stratify hrHPV DNA-positive women of different cytology classes for risk of high-grade cervical intraepithelial neoplasia or worse (cervical precancer or cancer, i.e., cervical intraepithelial neoplasia grade 2 or higher [≥CIN2]). A total of 375 women participating in population-based screening, with a GP5+/6+-PCR hrHPV DNA-positive cervical scrape with normal cytology (n = 202), borderline or mild dyskaryosis (BMD) (n = 88), or moderate dyskaryosis or worse (>BMD) (n = 85), were enrolled. Cervical scrapes were additionally subjected to HPV16/18/31/33/45 E6/E7 mRNA analysis by PreTect HPV-Proofer (mRNA test). Referral and follow-up policies were based on cytology, hrHPV DNA, and mRNA testing. The primary study endpoint was the number of ≥CIN2 detected within 3 years of follow-up. The mRNA positivity increased with the severity of cytological abnormality, ranging from 32% (64/202) in hrHPV DNA-positive women with normal cytology to 47% (41/88) in BMD and 68% (58/85) in >BMD groups (P cytology, i.e., 0.55 (95% confidence interval [95% CI], 0.34 to 0.76) in mRNA-positive versus 0.20 (95% CI, 0.07 to 0.33) in mRNA-negative women. In hrHPV DNA-positive women with BMD or >BMD, the result of the mRNA test did not influence the ≥CIN2 risk. In conclusion, mRNA testing by PreTect HPV-Proofer might be of value to select hrHPV DNA-positive women with normal cytology in need of immediate referral for colposcopy. PMID:22553244

The Perceived Importance of HR duties to Danish line managers

DEFF Research Database (Denmark)

Brandl, Julia; Madsen, Mona Toft; Madsen, Henning

2009-01-01

Today, HR scholars widely acknowledge that realising HRM requires the involvement of all managers and that the personal motivation of line managers plays an important role in their successful involvement. Yet, previous research has neglected to study how line managers rate the importance of parti...

Research on electron beam welding technology of steel HR-4

International Nuclear Information System (INIS)

Guo Peng; Guan Kai

2001-01-01

The electron beam weldability of HR- 4 steels (J75 and J90) is studied and the welding parameters needed for design and usage are presented. The assessment on the effect of mechanical properties by different processing order of welding and heat-treatment is made

HR practices for enhancing sustainable employability : implementation, use, and outcomes

NARCIS (Netherlands)

Ybema, Jan Fekke; van Vuuren, Tinka; van Dam, Karen

2017-01-01

With the aging of the workforce, organizations need to maintain or improve the sustainable employability of their workforce throughout their working life. This raises the question which HR practices increase workers’ sustainable employability at work. The aim of this study is to investigate the

Atypical Employment Relationships and Commitment: Wishful Thinking or HR Challenge?

NARCIS (Netherlands)

Torka, Nicole

2004-01-01

Nowadays, simultaneously maintaining flexible working practices and commitment is an important topic for HR managers since they both can contribute to organisational success. However, many HRM researchers and practitioners are unsure whether these can go together as job security is often seen as a

Statistical HR diagrams for one hundred and fifteen thousand proper-motion stars

International Nuclear Information System (INIS)

Luyten, W.J.

1978-01-01

Since regular HR diagrams require apparent magnitudes, colors or spectra, and parallaxes, and such complete data are available for relatively few stars, there may be some advantage in making up diagrams which utilize proper motions instead of parallaxes, and are thus statistically similar to an HR diagram. The reduced proper motion, first used by Hertzsprung, is defined as H=m+5+5log μ, but may also be written as H=M+5log T, where T is the tangential velocity, and is expressed in astronomical units per year. A diagram plotting H against color will thus contain the considerable dispersion in tangential velocity which is a serious disadvantage. However, this is outweighed by two practical advantages. First, the one and the same person who does the proper motion survey can, and does also determine the other two quantities needed. Second, when using data obtained from such a proper motion survey one deals, statistically, with all the stars within a given distance and the results, therefore, are much more representative of the real situation in space than many HR diagrams which often contain an unrealistic preponderance of giants. (Auth.)

Human XPC-hHR23B interacts with XPA-RPA in the recognition of triplex-directed psoralen DNA interstrand crosslinks

DEFF Research Database (Denmark)

Thoma, Brian S; Wakasugi, Mitsuo; Christensen, Jesper

2005-01-01

(NER), XPA-RPA, recognizes DNA ICLs. We now report the use of triplex technology to direct a site-specific psoralen ICL to a target DNA substrate to determine whether the human global genome NER damage recognition complex, XPC-hHR23B, recognizes this lesion. Our results demonstrate that XPC-hHR23B...... recognizes psoralen ICLs, which have a structure fundamentally different from other lesions that XPC-hHR23B is known to bind, with high affinity and specificity. XPC-hHR23B and XPA-RPA protein complexes were also observed to bind psoralen ICLs simultaneously, demonstrating not only that psoralen ICLs...... are recognized by XPC-hHR23B alone, but also that XPA-RPA may interact cooperatively with XPC-hHR23B on damaged DNA, forming a multimeric complex. Since XPC-hHR23B and XPA-RPA participate in the recognition and verification of DNA damage, these results support the hypothesis that interplay between components...

Status of SiO2/TiO2 HR coating damage

International Nuclear Information System (INIS)

Lowermilk, W.H.

1979-01-01

The data, observations, and conclusions from a number of experiments on high-reflector (HR) coating damage which were done in FY 1979 are summarized. Damage threshold measurements for the experiments described are presented

The efficiency of SAP in improving the HR performance case study ...

African Journals Online (AJOL)

The efficiency of SAP in improving the HR performance case study: Masdar ... administrative and strategic levels, as well as identifying the contribution of ... Keywords: SAP, human resources management, Masdar Building Materials Company ...

Deep Thermal Infrared Imaging of HR 8799 bcde: New Atmospheric Constraints and Limits on a Fifth Planet

OpenAIRE

Currie, Thayne; Burrows, Adam; Girard, Julien H.; Cloutier, Ryan; Fukagawa, Misato; Sorahana, Satoko; Kuchner, Marc; Kenyon, Scott J.; Madhusudhan, Nikku; Itoh, Yoichi; Jayawardhana, Ray; Matsumura, Soko; Pyo, Tae-Soo

2014-01-01

We present new $L^\\prime$ (3.8 $\\mu m$) and Br-$\\alpha$ (4.05 $\\mu m$) data and reprocessed archival $L^\\prime$ data for the young, planet-hosting star HR 8799 obtained with Keck/NIRC2, VLT/NaCo and Subaru/IRCS. We detect all four HR 8799 planets in each dataset at a moderate to high signal-to-noise (SNR $\\gtrsim$ 6-15). We fail to identify a fifth planet, "HR 8799 f", at $r$ $

Site specific health and safety plan, 100-HR-3 pump and treat. Revision 2

International Nuclear Information System (INIS)

St John, C.H.

1997-09-01

The 100-HR-3 Pump and Treat system is a groundwater remedial action to remove Hexavalent Chromium (Cr+6) from the groundwater underlying the 100-HR-3 Operable Unit. This plan covers operation, maintenance, repairs, resin exchange and equipment removal/installation. The 100-HR-3 Operable Unit addresses groundwater underlying the 100-D Area. The primary groundwater contaminant is Chromium +6. The chromium contamination resulted from the use of sodium dichromate during past reactor operations. Sodium dichromate was used to treat reactor coolant water during reactor operations. The purpose of this Pump and Treat system is to pump contaminated groundwater through above ground ion exchange resin and then return treated water to aquifer. Chromium levels extracted from the wells are anticipated to range in the low parts per billion (∼50 ppb) which is the drinking water limit for Cr+6

E2F1 interactions with hHR23A inhibit its degradation and promote DNA repair.

Science.gov (United States)

Singh, Randeep K; Dagnino, Lina

2016-05-03

Nucleotide excision repair (NER) is a major mechanism for removal of DNA lesions induced by exposure to UV radiation in the epidermis. Recognition of damaged DNA sites is the initial step in their repair, and requires multiprotein complexes that contain XPC and hHR23 proteins, or their orthologues. A variety of transcription factors are also involved in NER, including E2F1. In epidermal keratinocytes, UV exposure induces E2F1 phosphorylation, which allows it to recruit various NER factors to sites of DNA damage. However, the relationship between E2F1 and hHR23 proteins vis-à-vis NER has remained unexplored. We now show that E2F1 and hHR23 proteins can interact, and this interaction stabilizes E2F1, inhibiting its proteasomal degradation. Reciprocally, E2F1 regulates hHR23A subcellular localization, recruiting it to sites of DNA photodamage. As a result, E2F1 and hHR23A enhance DNA repair following exposure to UV radiation, contributing to genomic stability in the epidermis.

hrHPV E5 oncoprotein: immune evasion and related immunotherapies.

Science.gov (United States)

de Freitas, Antonio Carlos; de Oliveira, Talita Helena Araújo; Barros, Marconi Rego; Venuti, Aldo

2017-05-25

The immune response is a key factor in the fight against HPV infection and related cancers, and thus, HPV is able to promote immune evasion through the expression of oncogenes. In particular, the E5 oncogene is responsible for modulation of several immune mechanisms, including antigen presentation and inflammatory pathways. Moreover, E5 was suggested as a promising therapeutic target, since there is still no effective medical therapy for the treatment of HPV-related pre-neoplasia and cancer. Indeed, several studies have shown good prospective for E5 immunotherapy, suggesting that it could be applied for the treatment of pre-cancerous lesions. Thus, insofar as the majority of cervical, oropharyngeal and anal cancers are caused by high-risk HPV (hrHPV), mainly by HPV16, the aim of this review is to discuss the immune pathways interfered by E5 oncoprotein of hrHPV highlighting the various aspects of the potential immunotherapeutic approaches.

A combined multiwavelength VLA/ALMA/Chandra study unveils the complex magnetosphere of the B-type star HR5907

Science.gov (United States)

Leto, P.; Trigilio, C.; Oskinova, L. M.; Ignace, R.; Buemi, C. S.; Umana, G.; Ingallinera, A.; Leone, F.; Phillips, N. M.; Agliozzo, C.; Todt, H.; Cerrigone, L.

2018-05-01

We present new radio/millimeter measurements of the hot magnetic star HR 5907 obtained with the VLA and ALMA interferometers. We find that HR 5907 is the most radio luminous early type star in the cm-mm band among those presently known. Its multi-wavelength radio light curves are strongly variable with an amplitude that increases with radio frequency. The radio emission can be explained by the populations of the non-thermal electrons accelerated in the current sheets on the outer border of the magnetosphere of this fast-rotating magnetic star. We classify HR 5907 as another member of the growing class of strongly magnetic fast-rotating hot stars where the gyro-synchrotron emission mechanism efficiently operates in their magnetospheres. The new radio observations of HR 5907 are combined with archival X-ray data to study the physical condition of its magnetosphere. The X-ray spectra of HR 5907 show tentative evidence for the presence of non-thermal spectral component. We suggest that non-thermal X-rays originate a stellar X-ray aurora due to streams of non-thermal electrons impacting on the stellar surface. Taking advantage of the relation between the spectral indices of the X-ray power-law spectrum and the non-thermal electron energy distributions, we perform 3-D modelling of the radio emission for HR 5907. The wavelength-dependent radio light curves probe magnetospheric layers at different heights above the stellar surface. A detailed comparison between simulated and observed radio light curves leads us to conclude that the stellar magnetic field of HR 5907 is likely non-dipolar, providing further indirect evidence of the complex magnetic field topology of HR 5907.

The hr locus and the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in newborn mice

Energy Technology Data Exchange (ETDEWEB)

Connor, M J [Div. of Dermatology, Dept. of Medicine, UCLA School of Medicine, Los Angeles, CA (United States) Research Service, Veterans Administration West Los Angeles Medical Center, Los Angeles, CA (United States); Puhvel, S M [Div. of Dermatology, Dept. of Medicine, UCLA School of Medicine, Los Angeles, CA (United States) Research Service, Veterans Administration West Los Angeles Medical Center, Los Angeles, CA (United States); Sakamoto, M [Div. of Dermatology, Dept. of Medicine, UCLA School of Medicine, Los Angeles, CA (United States) Research Service, Veterans Administration West Los Angeles Medical Center, Los Angeles, CA (United States); Nanthur, J [Div. of Dermatology, Dept. of Medicine, UCLA School of Medicine, Los Angeles, CA (United States) Research Service, Veterans Administration West Los Angeles Medical Center, Los Angeles, CA (United States)

1994-12-01

In mice, the recessive mutation hairless (hr) controls the cutaneous response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) but its influence on TCDD's systemic toxicity is unclear. To clarify this, we compared the effects of lactational TCDD exposure on standardized litters of newborn HRS/J mice homozygous for either hr or + that were fostered by haired dams exposed to 0, 6, 8 or 12 [mu]g TCDD/kg body weight on postnatal day 0. At 12 [mu]g/kg, TCDD was lethal to both haired and hairless pups. At the lower doses (6 and 8 [mu]g/kg) the survival of hr/hr pups was significantly lower than +/+ pups. Affected pups succumbed following a 1 to 2-day period of cachexia and wasting. As has been reported for other mouse strains, TCDD exposure impacted on their neonatal development and lessened the time to eye opening for both haired and hairless pups. However, the hairless animals were affected at lower doses than were the haired. The results of this study document that the hr/hr genotype does influence the systemic toxicity of TCDD in mice. (orig.)

The hr locus and the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in newborn mice

Energy Technology Data Exchange (ETDEWEB)

Connor, M.J. (Div. of Dermatology, Dept. of Medicine, UCLA School of Medicine, Los Angeles, CA (United States) Research Service, Veterans Administration West Los Angeles Medical Center, Los Angeles, CA (United States)); Puhvel, S.M. (Div. of Dermatology, Dept. of Medicine, UCLA School of Medicine, Los Angeles, CA (United States) Research Service, Veterans Administration West Los Angeles Medical Center, Los Angeles, CA (United States)); Sakamoto, M. (Div. of Dermatology, Dept. of Medicine, UCLA School of Medicine, Los Angeles, CA (United States) Research Service, Veterans Administration West Los Angeles Medical Center, Los Angeles, CA (United States)); Nanthur, J. (Div. of Dermatology, Dept. of Medicine, UCLA School of Medicine, Los Angeles, CA (United States) Research Service, Veterans Administration West Los Angeles Medical Center, Los Angeles, CA (United States))

1994-12-01

In mice, the recessive mutation hairless (hr) controls the cutaneous response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) but its influence on TCDD's systemic toxicity is unclear. To clarify this, we compared the effects of lactational TCDD exposure on standardized litters of newborn HRS/J mice homozygous for either hr or + that were fostered by haired dams exposed to 0, 6, 8 or 12 [mu]g TCDD/kg body weight on postnatal day 0. At 12 [mu]g/kg, TCDD was lethal to both haired and hairless pups. At the lower doses (6 and 8 [mu]g/kg) the survival of hr/hr pups was significantly lower than +/+ pups. Affected pups succumbed following a 1 to 2-day period of cachexia and wasting. As has been reported for other mouse strains, TCDD exposure impacted on their neonatal development and lessened the time to eye opening for both haired and hairless pups. However, the hairless animals were affected at lower doses than were the haired. The results of this study document that the hr/hr genotype does influence the systemic toxicity of TCDD in mice. (orig.)

A critical role of the nuclear receptor HR3 in regulation of gonadotrophic cycles of the mosquito Aedes aegypti.

Directory of Open Access Journals (Sweden)

Daniel Mane-Padros

Full Text Available The orphan nuclear receptor HR3 is essential for developmental switches during insect development and metamorphosis regulated by 20-hydroxyecdysone (20E. Reproduction of female mosquitoes of the major vector of Dengue fever, Aedes aegypti, is cyclic because of its dependence on blood feeding. 20E is an important hormone regulating vitellogenic events in this mosquito; however, any role for HR3 in 20E-driven reproductive events has not been known. Using RNA interference (RNAi approach, we demonstrated that Aedes HR3 plays a critical role in a timely termination of expression of the vitellogenin (Vg gene encoding the major yolk protein precursor. It is also important for downregulation of the Target-of-Rapamycin pathway and activation of programmed autophagy in the Aedes fat body at the end of vitellogenesis. HR3 is critical in activating betaFTZ-F1, EcRB and USPA, the expressions of which are highly elevated at the end of vitellogenesis. RNAi depletion of HR3 (iHR3 prior to the first gonadotrophic cycle affects a normal progression of the second gonadotrophic cycle. Most of ovaries 24 h post second blood meal from iHR3 females in the second cycle were small with follicles that were only slightly different in length from of those of resting stage. In addition, these iHR3 females laid a significantly reduced number of eggs per mosquito as compared to those of iMal and the wild type. Our results indicate an important role of HR3 in regulation of 20E-regulated developmental switches during reproductive cycles of A. aegypti females.

Sublethal concentrations of 17-AAG suppress homologous recombination DNA repair and enhance sensitivity to carboplatin and olaparib in HR proficient ovarian cancer cells.

Science.gov (United States)

Choi, Young Eun; Battelli, Chiara; Watson, Jacqueline; Liu, Joyce; Curtis, Jennifer; Morse, Alexander N; Matulonis, Ursula A; Chowdhury, Dipanjan; Konstantinopoulos, Panagiotis A

2014-05-15

The promise of PARP-inhibitors(PARPis) in the management of epithelial ovarian cancer(EOC) is tempered by the fact that approximately 50% of patients with homologous recombination (HR)-proficient tumors do not respond well to these agents. Combination of PARPis with agents that inhibit HR may represent an effective strategy to enhance their activity in HR-proficient tumors. Using a bioinformatics approach, we identified that heat shock protein 90 inhibitors(HSP90i) may suppress HR and thus revert HR-proficient to HR-deficient tumors. Analysis of publicly available gene expression data showed that exposure of HR-proficient breast cancer cell lines to HSP90i 17-AAG(17-allylamino-17-demethoxygeldanamycin) downregulated HR, ATM and Fanconi Anemia pathways. In HR-proficient EOC cells, 17-AAG suppressed HR as assessed using the RAD51 foci formation assay and this was further confirmed using the Direct Repeat-GFP reporter assay. Furthermore, 17-AAG downregulated BRCA1 and/or RAD51 protein levels, and induced significantly more γH2AX activation in combination with olaparib compared to olaparib alone. Finally, sublethal concentrations of 17-AAG sensitized HR-proficient EOC lines to olaparib and carboplatin but did not affect sensitivity of the HR-deficient OVCAR8 line arguing that the 17-AAG mediated sensitization is dependent on suppression of HR. These results provide a preclinical rationale for using a combination of olaparib/17-AAG in HR-proficient EOC.

The high resolution optical instruments for the Pleiades HR Earth observation satellites

Science.gov (United States)

Gaudin-Delrieu, Catherine; Lamard, Jean-Luc; Cheroutre, Philippe; Bailly, Bruno; Dhuicq, Pierre; Puig, Olivier

2017-11-01

Coming after the SPOT satellites series, PLEIADESHR is a CNES optical high resolution satellite dedicated to Earth observation, part of a larger optical and radar multi-sensors system, ORFEO, which is developed in cooperation between France and Italy for dual Civilian and Defense use. The development of the two PLEIADES-HR cameras was entrusted by CNES to Thales Alenia Space. This new generation of instrument represents a breakthrough in comparison with the previous SPOT instruments owing to a significant step in on-ground resolution, which approaches the capabilities of aerial photography. The PLEIADES-HR instrument program benefits from Thales Alenia Space long and successful heritage in Earth observation from space. The proposed solution benefits from an extensive use of existing products, Cannes Space Optics Centre facilities, unique in Europe, dedicated to High Resolution instruments. The optical camera provides wide field panchromatic images supplemented by 4 multispectral channels with narrow spectral bands. The optical concept is based on a four mirrors Korsch telescope. Crucial improvements in detector technology, optical fabrication and electronics make it possible for the PLEIADES-HR instrument to achieve the image quality requirements while respecting the drastic limitations of mass and volume imposed by the satellite agility needs and small launchers compatibility. The two flight telescopes were integrated, aligned and tested. After the integration phase, the alignment, mainly based on interferometric measurements in vacuum chamber, was successfully achieved within high accuracy requirements. The wave front measurements show outstanding performances, confirmed, after the integration of the PFM Detection Unit, by MTF measurements on the Proto-Flight Model Instrument. Delivery of the proto flight model occurred mi-2008. The FM2 Instrument delivery is planned Q2-2009. The first optical satellite launch of the PLEIADES-HR constellation is foreseen

Monitoring training status with HR measures: do all roads lead to Rome?

Directory of Open Access Journals (Sweden)

Martin eBuchheit

2014-02-01

Full Text Available Monitoring an athlete's physiological status in response to various types and volumes of (aerobic-oriented training can provide useful information for optimizing training programs. Measures of resting, exercise and recovery heart rate (HR are receiving increasing interest for monitoring fatigue, fitness and endurance performance responses, which has direct implications for adjusting training load 1 daily during specific training blocks and 2 throughout the competitive season. These measures are still not widely implemented to monitor athletes’ responses to training load, probably because of apparent contradictory findings in the literature. In this review I contend that most of the contradictory findings are related to methodological inconsistencies and/or misinterpretation of the data rather than to limitations of heart rate measures to accurately inform on training status. I also provide evidence that measures derived from 5-min (almost daily recordings of resting (indices capturing beat-to-beat changes in HR, reflecting parasympathetic activity and submaximal exercise (30- to 60-s average HR are likely the most useful monitoring tools. For appropriate interpretation at the individual level, changes in a given measure should be interpreted by taking into account the error of measurement and the smallest important change of the measure, as well as the training context (training phase, load and intensity distribution. The decision to use a given measure should be based upon the level of information that is required by the athlete, the marker’s sensitivity to changes in training status and the practical constrains required for the measurements. However, measures of HR cannot inform on all aspects of wellness, fatigue and performance, so their use in combination with daily training logs, psychometric questionnaires and non-invasive, cost-effective performance tests such as a countermovement jump may offer a complete solution to monitor

Site specific health and safety plan, 100-HR-3 pump and treat. Revision 1

International Nuclear Information System (INIS)

Tuttle, B.G.

1996-06-01

The 100-HR-3 Operable Unit encompasses groundwater contamination underlying the 100-D and 100-H Areas. The primary contaminate is chromium VI. The sources of chromium contamination resulted from the use of sodium dichromate during past reactor operations. The purpose of the 100-HR-3 Pump-and-Treat system is to pump contaminated groundwater through aboveground ion exchange resin and then return the treated waster to the aquifer. This plan covers operation, maintenance, repairs, and pump removal/installation

Design of the high resolution optical instrument for the Pleiades HR Earth observation satellites

Science.gov (United States)

Lamard, Jean-Luc; Gaudin-Delrieu, Catherine; Valentini, David; Renard, Christophe; Tournier, Thierry; Laherrere, Jean-Marc

2017-11-01

As part of its contribution to Earth observation from space, ALCATEL SPACE designed, built and tested the High Resolution cameras for the European intelligence satellites HELIOS I and II. Through these programmes, ALCATEL SPACE enjoys an international reputation. Its capability and experience in High Resolution instrumentation is recognised by the most customers. Coming after the SPOT program, it was decided to go ahead with the PLEIADES HR program. PLEIADES HR is the optical high resolution component of a larger optical and radar multi-sensors system : ORFEO, which is developed in cooperation between France and Italy for dual Civilian and Defense use. ALCATEL SPACE has been entrusted by CNES with the development of the high resolution camera of the Earth observation satellites PLEIADES HR. The first optical satellite of the PLEIADES HR constellation will be launched in mid-2008, the second will follow in 2009. To minimize the development costs, a mini satellite approach has been selected, leading to a compact concept for the camera design. The paper describes the design and performance budgets of this novel high resolution and large field of view optical instrument with emphasis on the technological features. This new generation of camera represents a breakthrough in comparison with the previous SPOT cameras owing to a significant step in on-ground resolution, which approaches the capabilities of aerial photography. Recent advances in detector technology, optical fabrication and electronics make it possible for the PLEIADES HR camera to achieve their image quality performance goals while staying within weight and size restrictions normally considered suitable only for much lower performance systems. This camera design delivers superior performance using an innovative low power, low mass, scalable architecture, which provides a versatile approach for a variety of imaging requirements and allows for a wide number of possibilities of accommodation with a mini

Transgenic Cotton Plants Expressing the HaHR3 Gene Conferred Enhanced Resistance to Helicoverpa armigera and Improved Cotton Yield.

Science.gov (United States)

Han, Qiang; Wang, Zhenzhen; He, Yunxin; Xiong, Yehui; Lv, Shun; Li, Shupeng; Zhang, Zhigang; Qiu, Dewen; Zeng, Hongmei

2017-08-30

RNA interference (RNAi) has been developed as an efficient technology. RNAi insect-resistant transgenic plants expressing double-stranded RNA (dsRNA) that is ingested into insects to silence target genes can affect the viability of these pests or even lead to their death. HaHR3 , a molt-regulating transcription factor gene, was previously selected as a target expressed in bacteria and tobacco plants to control Helicoverpa armigera by RNAi technology. In this work, we selected the dsRNA- HaHR3 fragment to silence HaHR3 in cotton bollworm for plant mediated-RNAi research. A total of 19 transgenic cotton lines expressing HaHR3 were successfully cultivated, and seven generated lines were used to perform feeding bioassays. Transgenic cotton plants expressing ds HaHR3 were shown to induce high larval mortality and deformities of pupation and adult eclosion when used to feed the newly hatched larvae, and 3rd and 5th instar larvae of H. armigera . Moreover, HaHR3 transgenic cotton also demonstrated an improved cotton yield when compared with controls.

HR diagrams derived from the Michigan Spectral Catalogue

International Nuclear Information System (INIS)

Houk, N.; Fesen, R.

1978-01-01

The authors present some HR diagrams constructed using data from the Michigan Spectral Catalogues. Houk (1975) has been systematically reclassifying the Henry Draper stars on the MK system, from the south pole northward. Objective-prism plates, with a reciprocal dispersion of 108 A/mm, have been taken with the Michigan Curtis Schmidt telescope at Cerro Tololo Inter-American Observatory in Chile. The spectra are classified visually from the plates, and the results are put onto IBM cards and magnetic tape from which the catalogues are produced. (Auth.)

Calcium isotope measurement by combined HR-MC-ICPMS and TIMS

DEFF Research Database (Denmark)

Schiller, Martin; Paton, Chad; Bizzarro, Martin

2012-01-01

studies demonstrate that it is possible to measure the mass-dependent Ca isotope composition of terrestrial materials using HR-MC-ICPMS with an external reproducibility comparable to that typically obtained with double spike TIMS techniques. The resolution of the mass-independent 43Ca, 46Ca and 48Ca data...

HR Manager Leadership in Quality Improvement in a College Environment

Science.gov (United States)

Sharabi, Moshe

2010-01-01

Purpose: The purpose of this paper is to present the influence of the human resource (HR) manager on the quality of service in an academic college, and the human resource management (HRM) outcomes of the process. Design/methodology/approach: The paper relates to a customer satisfaction survey. More than 120 questionnaires were completed by the…

Microturbulence as a third dimension in the G-K giant region of the HR diagram

International Nuclear Information System (INIS)

Foy, R.

1978-01-01

The structure of the HR diagram in the G-K giant region is complex, because of the funneling effect and of the intersection of evolutionary tracks for different stellar masses. Therefore it is impossible to derive the age of a cool giant from its location in the HR diagram alone. To remove this indeterminacy a third dimension is needed, and the author suggests microturbulence as the appropriate observational parameter. (Auth.)

Doctor-patient relationships (DPR) in China: managers and clinicians’ twofold pathways from commitment HR practices

OpenAIRE

Ma, S.; Xu, X.; Trigo, V.; Ramalho, N. J. C.

2017-01-01

Purpose: The first objective of this research is to develop and test theory on how commitment human resource (HR) practices affect hospital professionals’ job satisfaction that motivates them to generate desirable patient care and subsequently improve doctor-patient relationships (DPR). The second objective is to examine how commitment HR practices influence in different ways hospital managers and clinicians. Methodology: Using a cross-sectional survey, data were collect from 508 clinicians a...

Next HR Department public meeting

CERN Multimedia

2016-01-01

Dear Colleagues, I am pleased to invite you to the next public meeting organized by the HR Department, which will take place on Tuesday 28 June at 3 p.m. in the Council Chamber. A drink will be served after the meeting as of 16:30 This meeting will be the opportunity to revisit the specificities of the Career Structure measures and Benchmark Jobs, what they entail and how they will be implemented, and to answer your questions. This meeting is also important for me on a personal note, as I will bid you farewell, at least for a few years, taking special leave as of 1 August 2016 to take up the position of Director-General for Human Resources at the European Central Bank in Frankfurt.  Should you not be able to attend the meeting, it can also be followed via Webcast and the recording will be made available on Indico. I look forward to meeting you. Best regards, Anne-Sylvie Catherin Head of the Human Resources Department

Repeatability of central corneal thickness measurement with the Pentacam HR system

Directory of Open Access Journals (Sweden)

Ruiz Simonato Alonso

2012-02-01

Full Text Available PURPOSE: To assess the repeatability of central corneal thickness measurement at the geometrical center (Central Corneal Thickness - CCT given by the Pentacam High Resolution (HR Comprehensive Eye Scanner (Oculus, Wetzlar, Germany over time. METHODS: Prospective, single center, observational study. Two separate CCT measurements were taken by the Pentacam corneal tomography exam (CTm 3 to 12 months apart, and compared. RESULTS: One hundred and sixteen eyes (n=116 of 62 health patients were included in this study. Average CCT in first and last visits was 541.6±37 µm and 543.6±36.9 µm respectively. Mean difference between both measurements was 9.2±6.4 µm, and there was no statistically significant difference in CCT measurement between visits, with good correlation between them (P = 0.057, r² = 0,9209. CONCLUSION: Pentacam (HR CTm gives repeatable CCT measurements over time.

Atmospheric retrieval analysis of the directly imaged exoplanet HR 8799b

Energy Technology Data Exchange (ETDEWEB)

Lee, Jae-Min [University of Zürich, Institute for Theoretical Physics, Winterthurerstrasse 190, CH-8057 Zürich (Switzerland); Heng, Kevin [University of Bern, Center for Space and Habitability, Sidlerstrasse 5, CH-3012 Bern (Switzerland); Irwin, Patrick G. J., E-mail: lee@physik.uzh.ch, E-mail: kevin.heng@csh.unibe.ch, E-mail: irwin@atm.ox.ac.uk [University of Oxford, Atmospheric, Oceanic and Planetary Physics, Clarendon Laboratory, Parks Road, Oxford OX1 3PU (United Kingdom)

2013-12-01

Directly imaged exoplanets are unexplored laboratories for the application of the spectral and temperature retrieval method, where the chemistry and composition of their atmospheres are inferred from inverse modeling of the available data. As a pilot study, we focus on the extrasolar gas giant HR 8799b, for which more than 50 data points are available. We upgrade our non-linear optimal estimation retrieval method to include a phenomenological model of clouds that requires the cloud optical depth and monodisperse particle size to be specified. Previous studies have focused on forward models with assumed values of the exoplanetary properties; there is no consensus on the best-fit values of the radius, mass, surface gravity, and effective temperature of HR 8799b. We show that cloud-free models produce reasonable fits to the data if the atmosphere is of super-solar metallicity and non-solar elemental abundances. Intermediate cloudy models with moderate values of the cloud optical depth and micron-sized particles provide an equally reasonable fit to the data and require a lower mean molecular weight. We report our best-fit values for the radius, mass, surface gravity, and effective temperature of HR 8799b. The mean molecular weight is about 3.8, while the carbon-to-oxygen ratio is about unity due to the prevalence of carbon monoxide. Our study emphasizes the need for robust claims about the nature of an exoplanetary atmosphere to be based on analyses involving both photometry and spectroscopy and inferred from beyond a few photometric data points, such as are typically reported for hot Jupiters.

Limited field investigation report for the 100-HR-2 Operable Unit

International Nuclear Information System (INIS)

1995-07-01

This report summarizes the data collection and analysis activities conducted during the 100-HR-2 Operable Unit investigative phase and the associated qualitative risk assessment. The 100-HR-2 Operable Unit contains solid waste burial grounds, an ash pit, burn pits, electrical facilities, septic systems, and support facilities. All known and suspected areas of contamination were classified as solid waste burial grounds or low-priority waste sites based on the collective knowledge of the operable unit managers (representatives from the US Department of Energy, the US Environmental Protection Agency, and Washington State Department of Ecology during the preparation of the 100-HR-2 Operable Unit Work Plan (DOE-RL 1993f). Solid waste burial grounds were judged to pose sufficient risk(s), through one or more pathways, to require evaluation for an interim remedial measure as per the Hanford Past-Practice Strategy (DOE-RL 1991) and negotiations with the Department of Energy, US Environmental Protection Agency, and Washington State Department of Ecology. An interim remedial measure is intended to achieve remedies that are likely to lead to a final record of decision. Low-priority sites are those judged not to pose significant risk to require the streamlined evaluation. There were six low-priority waste sites and seven solid waste burial grounds identified. The purpose of this report is to: (1) provide a summary of site investigative activities; (2) refine the conceptual exposure model (as needed); (3) identify chemical- and location-specific corrective action requirements; and 4) provide a human health and ecological QRA associated with solid waste burial grounds

Global well-posedness for Schrödinger equation with derivative in H(R)

Science.gov (United States)

Miao, Changxing; Wu, Yifei; Xu, Guixiang

In this paper, we consider the Cauchy problem of the cubic nonlinear Schrödinger equation with derivative in H(R). This equation was known to be the local well-posedness for s⩾1/2 > (Takaoka, 1999 [27]), ill-posedness for s (Biagioni and Linares, 2001 [1], etc.) and global well-posedness for s>1/2 > (I-team, 2002 [10]). In this paper, we show that it is global well-posedness in the endpoint space H(R), which remained open previously. The main approach is the third generation I-method combined with a new resonant decomposition technique. The resonant decomposition is applied to control the singularity coming from the resonant interaction.

Acute hyperhydration reduces athlete biological passport OFF-hr score

DEFF Research Database (Denmark)

Bejder Rasmussen, Jacob; Hoffmann, M F; Ashenden, M

2016-01-01

Anecdotal evidence suggests that athletes hyperhydrate to mask prohibited substances in urine and potentially counteract suspicious fluctuations in blood parameters in the athlete biological passport (ABP). It is examined if acute hyperhydration changes parameters included in the ABP. Twenty...... ingestion, and 54% (n = 19), 45%, and 47% (n = 19) were identified 40, 60, and 80 min, respectively, after ingestion. In conclusion, acute hyperhydration reduces ABP OFF-hr and reduces ABP sensitivity....

High-performance HR practices, positive affect and employee outcomes

OpenAIRE

Mostafa, Ahmed

2017-01-01

Purpose – The purpose of this paper is to provide insight into the affective or emotional mechanisms that underlie the relationship between high-performance HR practices (HPHRP) and employee attitudes and behaviours. Drawing on affective events theory (AET), this paper examines a mediation model in which HPHRP influence positive affect which in turn affects job satisfaction and organizational citizenship behaviours (OCBs). Design/methodology/approach – Two-wave data was collected from a sampl...

How can HR practices support front-end innovation and increase the innovativeness of companies?

DEFF Research Database (Denmark)

Aagaard, Annabeth; Andersen, Torben

2014-01-01

to be reinterpreted in a context of heterogeneity and polyvalence. Finally performance management and talent management should play a greater role in emphasising exclusive values and rational goal-oriented behaviour among employees, compared to the more inclusive mainstream values that characterise much HRM......' innovativeness. If HR is to support these activities, focus should be on broader issues such as team-based organising, founded on a questioning attitude and a management style with a high level of empowerment. In addition, traditional HR themes such as recruitment, training and development have...

HR-MAS NMR allied to chemometric on Hancornia speciosa varieties differentiation

Energy Technology Data Exchange (ETDEWEB)

Flores, Igor S. [Instituto Federal de Goiás (IFG), Luziânia, GO (Brazil); Silva, Andressa K.; Chaves, Lazaro J.; Collevatti, Rosane G.; Lião, Luciano M., E-mail: lucianoliao@ufg.br [Universidade Federal de Goiás (UFG), Goiânia, GO (Brazil); Furquim, Leonnardo C. [Faculdade Objetivo, GO (Brazil); Castro, Carlos F.S. [Instituto Federal de Educação, Ciência e Tecnologia Goiano (IFGoiano), GO (Brazil)

2018-05-01

This work describes the potential of chemometric analyses applied to {sup 1}H high-resolution magic angle spinning nuclear magnetic resonance ({sup 1}H HR-MAS NMR) data for the chemotaxonomic investigation of Hancornia speciosa (Apocynaceae) varieties. This plant, popularly known as mangaba, has a complex morphological differentiation and thus chemical analyses can be used for their taxonomic classification. In comparison to traditional techniques, {sup 1}H HR-MAS NMR allied with chemometrics provided a simple and low cost method for chemotaxonomy. Leaves of four varieties of H. speciosa from a common garden experiment was studied and demonstrated that H. speciosa var. speciosa differs from others due to its specific metabolic profile, and var. pubescens was discriminated based on its high phenolic compound content. The distinction between the latter variety and gardineri is important once it allows for the selection of samples with greater commercial value, once they produce the largest and heaviest fruits. (author)

24 hr non-invasive ambulatory blood pressure and heart rate monitoring in Parkinson’s Disease

Directory of Open Access Journals (Sweden)

Eva eStübner

2013-05-01

Full Text Available Non-motor symptoms are now commonly recognized in Parkinson’s Disease (PD and can include dysautonomia. Impairment of cardiovascular autonomic function can occur at any stage of PD but is typically prevalent in advanced stages or related to (anti-parkinsonian drugs and can result in atypical blood pressure (BP readings and related symptoms such as orthostatic hypotension (OH and supine hypertension. OH is usually diagnosed with a head-up-tilt test (HUT or an (active standing test (also known as Schellong test in the laboratory, but 24 hour Ambulatory Blood Pressure Monitoring (ABPM in a home setting may have several advantages, such as providing an overview of symptoms in daily life alongside pathophysiology as well as assessment of treatment interventions. This, however, is only possible if ABPM is administrated correctly and an autonomic protocol (including a diary is followed. which will be discussed in this review. A 24hr ABPM does not only allow the detection of OH, if it is present, but also the assessment of cardiovascular autonomic dysfunction during and after various daily stimuli, such as postprandial and alcohol dependent hypotension, as well as exercise and drug induced hypotension. Furthermore, information about the circadian rhythm of BP and heart rate (HR can be obtained and establish whether or not a patient has a fall of BP at night (i.e. ‘dipper’ vs. non-‘dipper’. The information about nocturnal BP may also allow the investigation or detection of disorders such as sleep dysfunction, nocturnal movement disorders and obstructive sleep apnea, which are common in PD. Additionally, a 24hr ABPM should be conducted to examine the effectiveness of OH therapy. This review will outline the methodology of 24 hr ABPM in PD, summarize findings of such studies in PD and briefly consider common daily stimuli that might affect 24 Hr ABPM.

THE CHARA ARRAY ANGULAR DIAMETER OF HR 8799 FAVORS PLANETARY MASSES FOR ITS IMAGED COMPANIONS

International Nuclear Information System (INIS)

Baines, Ellyn K.; White, Russel J.; Jones, Jeremy; Boyajian, Tabetha; McAlister, Harold A.; Ten Brummelaar, Theo A.; Turner, Nils H.; Sturmann, Judit; Sturmann, Laszlo; Goldfinger, P. J.; Farrington, Christopher D.; Riedel, Adric R.; Huber, Daniel; Ireland, Michael; Von Braun, Kaspar; Ridgway, Stephen T.

2012-01-01

HR 8799 is an hF0 mA5 γ Doradus-, λ Bootis-, Vega-type star best known for hosting four directly imaged candidate planetary companions. Using the CHARA Array interferometer, we measure HR 8799's limb-darkened angular diameter to be 0.342 ± 0.008 mas (an error of only 2%). By combining our measurement with the star's parallax and photometry from the literature, we greatly improve upon previous estimates of its fundamental parameters, including stellar radius (1.44 ± 0.06 R ☉ ), effective temperature (7193 ± 87 K, consistent with F0), luminosity (5.05 ± 0.29 L ☉ ), and the extent of the habitable zone (HZ; 1.62-3.32 AU). These improved stellar properties permit much more precise comparisons with stellar evolutionary models, from which a mass and age can be determined, once the metallicity of the star is known. Considering the observational properties of other λ Bootis stars and the indirect evidence for youth of HR 8799, we argue that the internal abundance, and what we refer to as the effective abundance, is most likely near solar. Finally, using the Yonsei-Yale evolutionary models with uniformly scaled solar-like abundances, we estimate HR 8799's mass and age considering two possibilities: 1.516 +0.038 –0.024 M ☉ and 33 +7 –13.2 Myr if the star is contracting toward the zero-age main sequence or 1.513 +0.023 –0.024 M ☉ and 90 +381 –50 Myr if it is expanding from it. This improved estimate of HR 8799's age with realistic uncertainties provides the best constraints to date on the masses of its orbiting companions, and strongly suggests they are indeed planets. They nevertheless all appear to orbit well outside the HZ of this young star.

Screening for high risk human papilloma virus (HR-HPV) subtypes, among Sudanese patients with oral lesions.

Science.gov (United States)

Babiker, Ali Yousif; Eltom, Faris Margani; Abdalaziz, Mohamed S; Rahmani, Arshad; Abusail, Saadalnour; Ahmed, Hussain Gadelkareem

2013-01-01

HR-HPV subtypes are strongly linked to etiology of many human cancers including oral cancer. The epidemiology of infection with different HPV genotypes greatly varies in different countries. The aim of this study was to identify and genotype the HR-HPV subtypes in oral tissues obtained from Sudanese patients with oral lesions. In this retrospective study 200 patients with oral lesions were screened by molecular methods (PCR) for the presence of HR-HPV subtypes. Of the 200 patients, 100/200 were patients with oral cancer (ascertained as case group) and 100/200 were patients with non-neoplastic oral lesions (ascertained as control group). Out of the 200 patients, 12/200 (6%) were found with HR-HPV infection. Of the 12 positive patients, 8/12 (66.7%) were among cases and the remaining 4/12 (33.3%) were among control group. The distribution of different genotypes was: type HPV 16 6/12 (50%), HPV18 4/12 (34%), HPV 31 1/12 (8%) and HPV 33 1/12 (8%). In view of these findings, HPV particularly subtypes 16 and 18 play a role in the etiology of oral cancer in the Sudan.

Intelligence and Information-Sharing Elements of S.4 and H.R. 1

National Research Council Canada - National Science Library

Masse, Todd

2007-01-01

Title I of S.4 and Title VII of H.R. 1 include corresponding measures related to enhancing information and intelligence sharing, both horizontally within the Federal Government and vertically between the Federal Government and state...

Lifetime validation of high-reliability (>30,000hr) rotary cryocoolers for specific customer profiles

Science.gov (United States)

Cauquil, Jean-Marc; Seguineau, Cédric; Vasse, Christophe; Raynal, Gaetan; Benschop, Tonny

2018-05-01

The cooler reliability is a major performance requested by the customers, especially for 24h/24h applications, which are a growing market. Thales has built a reliability policy based on accelerate ageing and tests to establish a robust knowledge on acceleration factors. The current trend seems to prove that the RM2 mean time to failure is now higher than 30,000hr. Even with accelerate ageing; the reliability growth becomes hardly manageable for such large figures. The paper focuses on these figures and comments the robustness of such a method when projections over 30,000hr of MTTF are needed.

Examination of the fine interstitial changes of pneumoconiosis with high resolution computed tomography (HR-CT)

International Nuclear Information System (INIS)

Kido, Masamitsu; Miyazaki, Nobuyoshi; Harada, Susumu; Nakata, Hajime

1986-01-01

High resolution CT was performed in 14 patients with fine interstitial changes of pneumoconiosis and Review image was evaluated for the diagnostic accuracy as compared with conventional chest roentgenogram. Of the 14 Patients in the study, 7 were divided category 1 by the ILO U/C classification, 4 were category 2, 3 were category 3. Studies of lung function showed obstructive ventilatory disturbance characterized by moderate reduction in FEV 1.0% (58.6 ± 16.5 %) and V25/H (0.34 ± 0.24 l/sec/m). HR-CT defined more sensitive in the presence of fine lung nodules than conventional X-p, and showed high contrast interfaces provided by the aerated lung. HR-CT was also of value in detecting bulla, bleb, peripleural changes and hilar lymphadenopathy. Radiologic-pathologic correlation was examined on tne specimens of transbronchial lung biopsy in 4 patients, and revealed the diagnostic usefullness of HR-CT. (author)

ATTITUDE ASSESSMENT USING PLEIADES-HR CAPABILITIES

Directory of Open Access Journals (Sweden)

J. M. Delevit

2012-07-01

Full Text Available Since SPOT1, the French national space centre (CNES has worked on improving the geometry of Earth observation spacecrafts. The accuracy of sensor calibration is one of the main key points for any Earth observation application such as orthorectification, DEM generation or surface change detection. For the last twenty years CNES has developed two families of methods: absolute methods and relative methods. These methods are used to characterize a pushbroom acquisition along the detector line and the time line. By this way, the viewing directions are measured and the residual of the spacecraft’s attitude angles (not restituted by the Attitude and Orbit Control System is estimated. This information can complete the geometric model of all the scenes acquired by the instrument and is used in all geometric applications. This paper presents new attitude assessment methods taking advantage of the capabilities of Pléiades-HR in terms of agility and focal plane arrangement – panchromatic band and multispectral (MS bands.

Recombinant protein of heptad-repeat HR212, a stable fusion inhibitor with potent anti-HIV action in vitro

International Nuclear Information System (INIS)

Pang, Wei; Wang Ruirui; Yang Liumeng; Liu Changmei; Tien Po; Zheng Yongtang

2008-01-01

HR212, a recombinant protein expressed in Escherichia coli, has been previously reported to inhibit HIV-1 membrane fusion at low nanomolar level. Here we report that HR212 is effective in blocking laboratory strain HIV-1 IIIB entry and replication with EC 50 values of 3.92 ± 0.62 and 6.59 ± 1.74 nM, respectively, and inhibiting infection by clinic isolate HIV-1 KM018 with EC 50 values of 44.44 ± 10.20 nM, as well as suppressing HIV-1-induced cytopathic effect with an EC 50 value of 3.04 ± 1.20 nM. It also inhibited HIV-2 ROD and HIV-2 CBL-20 entry and replication in the μM range. Notably, HR212 was highly effective against T20-resistant strains with EC 50 values ranging from 5.09 to 7.75 nM. Unlike T20, HR212 showed stability sufficient to inhibit syncytia formation in a time-of-addition assay, and was insensitive to proteinase K digestion. These results suggest that HR212 has great potential to be further developed as novel HIV-1 fusion inhibitor for treatment of HIV/AIDS patients, particularly for those infected by T20-resistant variants

HR Technology Tools: Less Time on Paper and More on People

Science.gov (United States)

Tillman, Tom

2009-01-01

Many human resource managers face a dilemma. They would like to spend more time improving the overall work environment for employees. They want to help their executives save on workforce-related expenses, find and hire better talent, and improve existing talent through training and development. Unfortunately, most days, HR managers are stuck doing…

P/2006 HR30 (Siding Spring): A Low-activity Comet in Near-Earth Space

Science.gov (United States)

Hicks, Michael D.; Bauer, James M.

2007-01-01

The low cometary activity of P/2006 HR30 (Siding Spring) allowed a unique opportunity to study the nucleus of a periodic comet while near perihelion. P/2006 HR30 was originally targeted as a potential extinct comet, and we measured spectral reflectance and dust production using long-slit CCD spectroscopy and wide-field imaging obtained at the Palomar Mountain 200 inch telescope on 2006 August 3 and 4. The dust production Afp = 19.7 +/- 0.4 cm and mass-loss rate Q(dust) 4.1 +/- 0.1 kg/sec of the comet were approximately 2 orders of magnitude dust less than 1P/Halley at similar heliocentric distance. The VRI colors derived from the spectral reflectance were compared to Kuiper Belt objects, Centaurs, and other cometary nuclei. We found that the spectrum of P/2006 HR30 was consistent with other comets. However, the outer solar system bodies have a color distribution statistically distinct from cometary nuclei. It is our conjecture that cometary activity, most likely the reaccretion of ejected cometary dust, tends to moderate and mute the visible colors of the surface of cometary nuclei.

miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting LATS1

Energy Technology Data Exchange (ETDEWEB)

Liu, Shikai; Song, Lili, E-mail: commasll@163.com; Zhang, Liang; Zeng, Saitian; Gao, Fangyuan

2015-04-17

Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3′-UTR of large tumor suppressor kinase 1 (LATS1). Through direct binding, miR-21 can regulate LATS1 expression in cervical cancer cells. LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-LATS1 axis plays an important role in regulating radiosensitivity. - Highlights: • miR-21 is highly expressed in HR-HPV (+) radioresistant cervical cancer patients. • miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells. • miR-21 can decrease radiation induced G2/M block and increase S phase accumulation. • miR-21 modulates radiosensitivity cervical cancer cell by directly targeting LATS1.

miR-21 modulates resistance of HR-HPV positive cervical cancer cells to radiation through targeting LATS1

International Nuclear Information System (INIS)

Liu, Shikai; Song, Lili; Zhang, Liang; Zeng, Saitian; Gao, Fangyuan

2015-01-01

Although multiple miRNAs are found involved in radioresistance development in HR-HPV positive (+) cervical cancer, only limited studies explored the regulative mechanism of the miRNAs. miR-21 is one of the miRNAs significantly upregulated in HR-HPV (+) cervical cancer is also significantly associated with radioresistance. However, the detailed regulative network of miR-21 in radioresistance is still not clear. In this study, we confirmed that miR-21 overexpression was associated with higher level of radioresistance in HR-HPV (+) cervical cancer patients and thus decided to further explore its role. Findings of this study found miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells and decrease radiation induced G2/M block and increase S phase accumulation. By using dual luciferase assay, we verified a binding site between miR-21 and 3′-UTR of large tumor suppressor kinase 1 (LATS1). Through direct binding, miR-21 can regulate LATS1 expression in cervical cancer cells. LATS1 overexpression can reverse miR-21 induced higher colony formation rate and also reduced miR-21 induced S phase accumulation and G2/M phase block reduction under radiation treatment. These results suggested that miR-21-LATS1 axis plays an important role in regulating radiosensitivity. - Highlights: • miR-21 is highly expressed in HR-HPV (+) radioresistant cervical cancer patients. • miR-21 can negatively affect radiosensitivity of HR-HPV (+) cervical cancer cells. • miR-21 can decrease radiation induced G2/M block and increase S phase accumulation. • miR-21 modulates radiosensitivity cervical cancer cell by directly targeting LATS1

Nuclear licensing reform. Hearings before the Subcommittee on Energy and the Environment, House of Representatives, Ninety-Eighth Congress, First Session on H.R. 2511 and H.R. 2512, June 9 and 30, 1983

International Nuclear Information System (INIS)

Anon.

1984-01-01

Two bills (H.R. 2511 and H.R. 2512) amend licensing and siting regulations in the Atomic Energy Act by introducing the concept of one-stop licensing, encouraging standardized design and early site permits, and replacing adjudicatory proceedings with ''hybrid'' hearings. Witnesses speaking for and against the controversial proposals during the two-day hearing included Nunzio Palladino and other Commissioners of the Nuclear Regulatory Commission, Energy Secretary Hodel, and representatives of electric utilities, the nuclear industry, and environmental and public interest groups. Two appendices with additional material submitted for the hearing record follow the test of the two bills and the statements and testimony of 12 witnesses

Design criteria and design basis for the 100-HR-3 and 100-KR-4 pump-and-treat projects

International Nuclear Information System (INIS)

McKinley, W.S.; Winters, J.N.

1996-06-01

The 100-HR-3 and 100-KR-4 Operable Units are located in the 100 Area at the Hanford Site in Richland, Washington. The document describes the project objectives and design criteria to be used for the 100-HR-3 and 100-KR-4 groundwater pump-and-treat design activities

1H HR-MAS NMR and S180 cells: metabolite assignment and evaluation of pulse sequence

International Nuclear Information System (INIS)

Oliveira, Aline L. de; Martinelli, Bruno César B.; Lião, Luciano M.; Pereira, Flávia C.; Silveira-Lacerda, Elisangela P.; Alcantara, Glaucia B.

2014-01-01

High resolution magic angle spinning 1 H nuclear magnetic resonance spectroscopy (HR-MAS NMR) is a useful technique for evaluation of intact cells and tissues. However, optimal NMR parameters are crucial in obtaining reliable results. To identify the key steps for the optimization of HR-MAS NMR parameters, we assessed different pulse sequences and NMR parameters using sarcoma 180 (S180) cells. A complete assignment of the metabolites of S180 is given to assist future studies. (author)

High-resolution magnetic resonance imaging (HR-MRI) of the pleura and chest wall: Normal findings and pathological changes

International Nuclear Information System (INIS)

Bittner, R.C.; Schnoy, N.; Schoenfeld, N.; Grassot, A.; Loddenkemper, R.; Lode, H.; Kaiser, D.; Krumhaar, D.; Felix, R.

1995-01-01

To determine the value of high-resolution MRI in pleural and chest wall diseases, the normal and pathologic costal pleura and adjacent chest wall between paravertebral and the axillar region were examined with contrast enhanced high-resolution T 1 -weighted MRI images using a surface coil. Normal anatomy was evaluated in 5 healthy volunteers and a normal specimen of the thoracic wall, and correlation was made with corresponding HR-CT and histologic sections. CT-proved focal and diffuse changes of the pleura and the chest wall in 36 patients underwent HR-MRI, and visual comparison of MRI and CT was done retrospectively. Especially sagittal T 1 -weighted HR-MRI images allowed accurate delineation of the peripleural fat layer (PFL) and the innermost intercostal muscle (IIM), which served as landmarks of the intact inner chest wall. PFL and IIM were well delineated in 3/4 patients with tuberculous pleuritis, and in all 7 patients with non-specific pleuritis, as opposed to impairment of the PFL and/or the IIM, which was detected in 15/18 malignancies as a pattern of malignant chest wall involvement. In one case of tuberculous pleural empyema with edema of the inner chest wall HR-MRI produced false positive diagnosis of malignant disease. HR-MRI images improved non-invasive evaluation of pleural and chest wall diseases, and allowed for differentiation of bengin and malignant changes. (orig./MG) [de

The gap between research and practice: a replication study on the HR professionals' beliefs about effective human resource practices

NARCIS (Netherlands)

Sanders, Karin; van Riemsdijk, Maarten; Groen, B.A.C.

2008-01-01

In 2002 Rynes, Colbert and Brown asked human resource (HR) professionals to what extent they agreed with various HR research findings. Responses from 959 American participants showed that there are large discrepancies between research findings and practitioners' beliefs about effective human

10 MMBt/Hr AFBC Commercial Demonstration Cedar Lane Farms

Energy Technology Data Exchange (ETDEWEB)

Harold M. Keener; Mary H. Wicks; Tom Machamer; Dave Hoecke; Don Bonk; Bob Brown

2005-10-31

The objective of this project was to demonstrate and promote the commercialization of coal-fired atmospheric fluidized bed combustion (AFBC) systems, with limestone addition for SO2 emissions control and a baghouse for particulate emissions control. This AFBC system was targeted for small scale industrial-commercial-institutional space and process heat applications in the 4-40 MMBtu/hr size range. A cost effective and environmentally acceptable AFBC technology in this size range could displace a considerable amount of heating gas and oil with coal, while resulting in significant total cost savings to the owner/operators.

Teaching HR Professionals: The Classroom as a Community of Practice

Directory of Open Access Journals (Sweden)

Alex Avramenko

2013-05-01

Full Text Available This paper introduces an innovative course design incorporating both communities of practice and reflective practice as a learning strategy for part-time learners in higher education. The new design has been applied to teaching HR practitioners in a UK-based business school. Findings indicate that the suggested way of organizing teaching and learning for part-time professionals is very informative and facilitates a richer engagement with theory whilst addressing issues of practice.

The more the better…or is it? The contradictory effects of HR practices on knowledge sharing motivation and behavior

NARCIS (Netherlands)

Andreeva, T.; Sergeeva, A.

2016-01-01

This article examines how individual-level antecedents such as motivation and ability to share knowledge mediate the relationship between HR practices and knowledge-sharing behaviour. The results of a survey of 329 secondary school teachers reveal the contradictory effects of different HR practices

The selection and adaptation of staff as the basis of the successful implementation of HR strategy

Directory of Open Access Journals (Sweden)

Vanicheva A.G.

2016-11-01

Full Text Available the article deals with questions of effective strategies of HR policy in the field of selection and adaptation of staff in the company. The text gives an information about effective methods of selection and adaptation, also it draws our attention to development of communication between employees. This paper can help to pay managers’ attention to effective selection and adaptation taking into consideration that introduction of a new employee to a position is responsible enough. Probably, first days in a new company are crucial for the system of motivation of HR policy in the development of HR strategy. Much attention is given to stages of adaptation for employee or chief executive.

Chemical profile of beans cultivars (Phaseolus vulgaris) by 1H NMR - high resolution magic angle spinning (HR-MAS);Perfil quimico de cultivares de feijao (Phaseolus vulgaris) pela tecnica de high resolution magic angle spinning (HR-MAS)

Energy Technology Data Exchange (ETDEWEB)

Liao, Luciano Morais; Choze, Rafael; Cavalcante, Pedro Paulo Araujo; Santos, Suzana da Costa; Ferri, Pedro Henrique, E-mail: luciano@quimica.ufg.b [Universidade Federal de Goias (UFG), Goiania, GO (Brazil). Inst. de Quimica; Ferreira, Antonio Gilberto [Universidade Federal de Sao Carlos (UFScar), SP (Brazil). Dept. de Quimica

2010-07-01

The application of one-dimensional proton high-resolution magic angle spinning ({sup 1}H HR-MAS) NMR combined with a typical advantages of solid and liquid-state NMR techniques was used as input variables for the multivariate statistical analysis. In this paper, different cultivars of beans (Phaseolus vulgaris) developed and in development by EMBRAPA - Arroz e Feijao were analyzed by {sup 1}H HR-MAS, which have been demonstrated to be a valuable tool in its differentiation according chemical composition and avoid the manipulation of the samples as used in other techniques. (author)

Photoelectric photometry of the Am star HR = V423 Per

International Nuclear Information System (INIS)

Jerzykiewicz, M.

1989-01-01

This spectroscopic binary is the largest amplitude variable among Am stars. UBV observations of the star are presented. They show that in 1964 and 1965 it was constant in B and was only marginally variable in U. The hypothesis of the ellipsoidal variability of HR 976 is then discussed and found untenable. It is pointed out that this result may reopen the issue of light variability of Am stars. 10 refs., 2 figs., 2 tabs. (author)

Sex- and Site-Specific Normative Data Curves for HR-pQCT.

Science.gov (United States)

Burt, Lauren A; Liang, Zhiying; Sajobi, Tolulope T; Hanley, David A; Boyd, Steven K

2016-11-01

The purpose of this study was to develop age-, site-, and sex-specific centile curves for common high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite-element (FE) parameters for males and females older than 16 years. Participants (n = 866) from the Calgary cohort of the Canadian Multicentre Osteoporosis Study (CaMos) between the ages of 16 and 98 years were included in this study. Participants' nondominant radius and left tibia were scanned using HR-pQCT. Standard and automated segmentation methods were performed and FE analysis estimated apparent bone strength. Centile curves were generated for males and females at the tibia and radius using the generalized additive models for location, scale, and shape (GAMLSS) package in R. After GAMLSS analysis, age-, sex-, and site-specific centiles (10th, 25th, 50th, 75th, 90th) for total bone mineral density and trabecular number as well as failure load have been calculated. Clinicians and researchers can use these reference curves as a tool to assess bone health and changes in bone quality. © 2016 American Society for Bone and Mineral Research. © 2016 American Society for Bone and Mineral Research.

Are They Fit For Purpose? Exploring Managers' Experiences of UK HR Graduates & Employability Implications: A Pilot Study

OpenAIRE

Mullen, Emma

2014-01-01

The purpose of this research is to expand on existing understandings of graduate employability through exploring the lived experiences and perceptions of key informants, in this case, those with direct line management responsibilities for graduates. The context of this research is focused on Human Resources (HR) graduates, a discipline that has seen little qualitative inquiry across the Higher Education (HE), employability and HR literature, and which is currently dominated by skills-led appr...

Stability of Routine Biochemical Analytes in Whole Blood and Plasma From Lithium Heparin Gel Tubes During 6-hr Storage.

Science.gov (United States)

Monneret, Denis; Godmer, Alexandre; Le Guen, Ronan; Bravetti, Clotilde; Emeraud, Cecile; Marteau, Anthony; Alkouri, Rana; Mestari, Fouzi; Dever, Sylvie; Imbert-Bismut, Françoise; Bonnefont-Rousselot, Dominique

2016-09-01

The stability of biochemical analytes has already been investigated, but results strongly differ depending on parameters, methodologies, and sample storage times. We investigated the stability for many biochemical parameters after different storage times of both whole blood and plasma, in order to define acceptable pre- and postcentrifugation delays in hospital laboratories. Twenty-four analytes were measured (Modular® Roche analyzer) in plasma obtained from blood collected into lithium heparin gel tubes, after 2-6 hr of storage at room temperature either before (n = 28: stability in whole blood) or after (n = 21: stability in plasma) centrifugation. Variations in concentrations were expressed as mean bias from baseline, using the analytical change limit (ACL%) or the reference change value (RCV%) as acceptance limit. In tubes stored before centrifugation, mean plasma concentrations significantly decreased after 3 hr for phosphorus (-6.1% [95% CI: -7.4 to -4.7%]; ACL 4.62%) and lactate dehydrogenase (LDH; -5.7% [95% CI: -7.4 to -4.1%]; ACL 5.17%), and slightly decreased after 6 hr for potassium (-2.9% [95% CI: -5.3 to -0.5%]; ACL 4.13%). In plasma stored after centrifugation, mean concentrations decreased after 6 hr for bicarbonates (-19.7% [95% CI: -22.9 to -16.5%]; ACL 15.4%), and moderately increased after 4 hr for LDH (+6.0% [95% CI: +4.3 to +7.6%]; ACL 5.17%). Based on RCV, all the analytes can be considered stable up to 6 hr, whether before or after centrifugation. This study proposes acceptable delays for most biochemical tests on lithium heparin gel tubes arriving at the laboratory or needing to be reanalyzed. © 2016 Wiley Periodicals, Inc.

HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome.

Directory of Open Access Journals (Sweden)

Ge Li

2010-06-01

Full Text Available HIV-1 Vpr is a virion-associated protein. Its activities link to viral pathogenesis and disease progression of HIV-infected patients. In vitro, Vpr moderately activates HIV-1 replication in proliferating T cells, but it is required for efficient viral infection and replication in vivo in non-dividing cells such as macrophages. How exactly Vpr contributes to viral replication remains elusive. We show here that Vpr stimulates HIV-1 replication at least in part through its interaction with hHR23A, a protein that binds to 19S subunit of the 26S proteasome and shuttles ubiquitinated proteins to the proteasome for degradation. The Vpr-proteasome interaction was initially discovered in fission yeast, where Vpr was shown to associate with Mts4 and Mts2, two 19S-associated proteins. The interaction of Vpr with the 19S subunit of the proteasome was further confirmed in mammalian cells where Vpr associates with the mammalian orthologues of fission yeast Mts4 and S5a. Consistently, depletion of hHR23A interrupts interaction of Vpr with proteasome in mammalian cells. Furthermore, Vpr promotes hHR23A-mediated protein-ubiquitination, and down-regulation of hHR23A using RNAi significantly reduced viral replication in non-proliferating MAGI-CCR5 cells and primary macrophages. These findings suggest that Vpr-proteasome interaction might counteract certain host restriction factor(s to stimulate viral replication in non-dividing cells.

Multiple Stars Across the H-R Diagram

CERN Document Server

Hubrig, Swetlana; Tokovinin, Andrei; Proceedings of the ESO Workshop held in Garching, Germany, 12-15 July 2005

2008-01-01

Stars show a marked tendency to be in systems of different multiplicity, ranging from simple binaries and triples to globular clusters with several 10,000's of stars. The formation and evolution of multiple systems remains a challenging part of astrophysics, and the contributions in this book report on the significant progress that had been made in this research field in the last years. The reader will find a variety of research topics addressed, such as the dynamical evolution in multiple stars, the effects of the environment on multiple system parameters, stellar evolution within multiple stars, multiplicity of massive stars, pre-main sequence and intermediate mass stars, multiplicity of low-mass stars from embedded protostars to open clusters, and brown dwarfs and extrasolar planets in multiples. This book presents the proceedings of the ESO Workshop on Multiple Stars across the H-R Diagram held in the summer of 2005.

Comparative study of the pharmacokinetics of carbon tetrachloride in the rat following repeated inhalation exposures of 8 and 11.5 hr/day

International Nuclear Information System (INIS)

Paustenbach, D.J.; Carlson, G.P.; Christian, J.E.; Born, G.S.

1986-01-01

To evaluate whether exposure to inhaled vapors for periods longer than 8 hr/day could affect the rates and routes of elimination, male Sprague-Dawley rats were repeatedly exposed to 100 ppm of radiolabeled carbon tetrachloride ( 14 CCl 4 ) in a closed-loop chamber. One group was exposed for 8 hr/day for 5 days and another group for 11.5 hr/day for 4 days. Two other groups were exposed for either 8 hr/day for 10 of 12 consecutive days or 11.5 hr/day for 7 of 10 days. The elimination of 14 C activity was measured in the expired air, urine, and feces for up to 100 hr following exposure and the pharmacokinetic parameters were determined. Following 2 weeks of exposure to the 8-hr/day schedule, 14 CCl 4 in the breath and 14 C activity in the feces comprised 45 and 48% of the total 14 C excreted, respectively. Following 2 weeks of exposure to the 11.5-hr/day schedule, the values were 32 and 62%, respectively, indicating that repeated exposure to the longer schedule altered the route of elimination of CCl 4 . Regardless of the period of exposure, less than 8% of the inhaled 14 CCl 4 was excreted in the urine and less than 2% was exhaled in the breath as the 14 CO 2 metabolite. Approximately 97-98% of the 14 C activity in the expired air was 14 CCl 4 . The quantities of 14 C noted in the feces and urine suggest that more than 60% of the inhaled CCl 4 was metabolized. Elimination of 14 CCl 4 and 14 CO 2 in the breath followed a two-compartment, first-order pharmacokinetic model (r2 = 0.98). For rats exposed 8 hr/day and 11.5 hr/day for 2 weeks, the average half-lives for elimination of 14 CCl 4 in the breath for the fast (alpha) and slow (beta) phases averaged 96 and 455 min, and 89 and 568 min, respectively. The average alpha and beta half-lives for elimination of 14 CO 2 in the breath

HELIOS–RETRIEVAL: An Open-source, Nested Sampling Atmospheric Retrieval Code; Application to the HR 8799 Exoplanets and Inferred Constraints for Planet Formation

Energy Technology Data Exchange (ETDEWEB)

Lavie, Baptiste; Mendonça, João M.; Malik, Matej; Demory, Brice-Olivier; Grimm, Simon L. [University of Bern, Space Research and Planetary Sciences, Sidlerstrasse 5, CH-3012, Bern (Switzerland); Mordasini, Christoph; Oreshenko, Maria; Heng, Kevin [University of Bern, Center for Space and Habitability, Sidlerstrasse 5, CH-3012, Bern (Switzerland); Bonnefoy, Mickaël [Université Grenoble Alpes, IPAG, F-38000, Grenoble (France); Ehrenreich, David, E-mail: baptiste.lavie@space.unibe.ch, E-mail: kevin.heng@csh.unibe.ch [Observatoire de l’Université de Genève, 51 chemin des Maillettes, 1290, Sauverny (Switzerland)

2017-09-01

We present an open-source retrieval code named HELIOS–RETRIEVAL, designed to obtain chemical abundances and temperature–pressure profiles by inverting the measured spectra of exoplanetary atmospheres. In our forward model, we use an exact solution of the radiative transfer equation, in the pure absorption limit, which allows us to analytically integrate over all of the outgoing rays. Two chemistry models are considered: unconstrained chemistry and equilibrium chemistry (enforced via analytical formulae). The nested sampling algorithm allows us to formally implement Occam’s Razor based on a comparison of the Bayesian evidence between models. We perform a retrieval analysis on the measured spectra of the four HR 8799 directly imaged exoplanets. Chemical equilibrium is disfavored for HR 8799b and c. We find supersolar C/H and O/H values for the outer HR 8799b and c exoplanets, while the inner HR 8799d and e exoplanets have a range of C/H and O/H values. The C/O values range from being superstellar for HR 8799b to being consistent with stellar for HR 8799c and being substellar for HR 8799d and e. If these retrieved properties are representative of the bulk compositions of the exoplanets, then they are inconsistent with formation via gravitational instability (without late-time accretion) and consistent with a core accretion scenario in which late-time accretion of ices occurred differently for the inner and outer exoplanets. For HR 8799e, we find that spectroscopy in the K band is crucial for constraining C/O and C/H. HELIOS–RETRIEVAL is publicly available as part of the Exoclimes Simulation Platform (http://www.exoclime.org).

The Phenomenon of Climate Change in Organization and HR- Related Literature: A Conceptual Brief Analysis

Directory of Open Access Journals (Sweden)

Mousa Mohamed

2018-05-01

Full Text Available Climate change has become one of the main challenges facing humanity. Over the past decade, this phenomenon, which may have been caused by natural variability and/or human activity, has attracted many scholars from different scientific disciplines to warn of its potential consequences. The author of this paper has decided to address the existence of this important phenomenon in organizational literature. However, upon exploring different academic databases, the rarity of research focusing on climate change and its relationship and/or effect on HR or organizational aspects became obvious. Accordingly, the author recommends other HR and organizational scholars devote considerable space to this phenomenon in their field.

National Hydrography Dataset Plus High Resolution (NHDPlus HR) - USGS National Map Downloadable Data Collection

Data.gov (United States)

U.S. Geological Survey, Department of the Interior — The High Resolution National Hydrography Dataset Plus (NHDPlus HR) is an integrated set of geospatial data layers, including the best available National Hydrography...

{sup 1}H HR-MAS NMR and S180 cells: metabolite assignment and evaluation of pulse sequence

Energy Technology Data Exchange (ETDEWEB)

Oliveira, Aline L. de; Martinelli, Bruno César B.; Lião, Luciano M. [Universidade Federal de Goiás (UFG), Goiânia, GO (Brazil). Instituto de Química. Lab. de RMN; Pereira, Flávia C.; Silveira-Lacerda, Elisangela P. [Universidade Federal de Goiás (UFG), Goiânia, GO (Brazil). Instituto de Ciências Biológicas. Laboratório Genética Molecular e Citogenética; Alcantara, Glaucia B., E-mail: glaucia.alcantara@ufms.br [Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS (Brazil). Inst. de Química

2014-07-01

High resolution magic angle spinning {sup 1}H nuclear magnetic resonance spectroscopy (HR-MAS NMR) is a useful technique for evaluation of intact cells and tissues. However, optimal NMR parameters are crucial in obtaining reliable results. To identify the key steps for the optimization of HR-MAS NMR parameters, we assessed different pulse sequences and NMR parameters using sarcoma 180 (S180) cells. A complete assignment of the metabolites of S180 is given to assist future studies. (author)

Supplement request for Support of MRS Symposium (PECASE: Active Microstructured Polymer Systems)

Science.gov (United States)

2015-07-06

and optics, and sensors. Key metrics for shape-shifting materials are the ability to: 1) dictate the geometry of the material; 2) control the rate of...architecture, science and engineering. For example, the ancient art of Japanese origami converts 2D sheets into 3D shapes. Techniques that mimic origami in a...speakers from the NSF EFRI ODISSEI program (National Science Foundation: Emerging Frontiers in Research and Innovation, Origami Design for Integration

Proton extrusion is an essential signalling component in the HR of epidermal single cells in the barley-powdery mildew interaction

DEFF Research Database (Denmark)

Zhou, F.S.; Andersen, C.H.; Burhenne, K.

2000-01-01

We propose a model for activation of the epidermal cell hypersensitive response (HR) in the barley/powdery mildew interaction. The model suggests that the plasma membrane proton pump (H+-ATPase) of epidermal cells is activated following penetration by an avirulent powdery mildew fungus...... in the incompatible interaction; (4) race-specific proton extrusion is observed underneath epidermal tissue detached from leaves inoculated 15 h earlier; and (5) treatment of leaves with fusicoccin, an activator of the plasma membrane H+-ATPase, increases the number of HR-cells in the compatible interaction........ This will cause an acidification of the apoplast towards the mesophyll cells, thereby activating generation of H2O2 from the mesophyll, which subsequently triggers the epidermal cell to undergo HR. The model is supported by the following data: (1) the earliest HR-related H2O2 is found in the attachment zones...

Organizations' Ways of Employing Early Retirees: The Role of Age-Based HR Policies.

Science.gov (United States)

Oude Mulders, Jaap; Henkens, Kène; Schippers, Joop

2015-06-01

We examine whether from an organizational perspective it is possible to distinguish different ways of employing early retirees and explore how the employment of early retirees is related to the application of 4 age-based human resource (HR) policies, namely demotion, offering training opportunities to older workers, offering early retirement, and allowing flexible working hours. We perform a latent class analysis on a sample of 998 Dutch organizations in order to categorize them based on 3 dimensions of their employment of early retirees. We then run a multinomial logistic regression to relate the employment of early retirees to the 4 age-based HR policies. We distinguish 4 types of organizations based on their way of employing early retirees: nonusers (52.6%), users for mainly standard work (20.8%), users for mainly nonstandard work (9.8%), and users for standard and nonstandard work (16.7%). We find that organizations that apply demotion, offer early retirement, and allow flexible working hours are more likely to be users for mainly standard work. Also, organizations that do not offer early retirement are less likely to employ early retirees. Age-based HR policies, especially demotion, offering early retirement, and allowing flexible working hours, are conducive to the employment of early retirees for mainly standard work. Broader implementation of these policies may provide opportunities for older workers to make a more gradual transition from work to retirement. © The Author 2013. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

State-of-the-art HR-US imaging findings of the most frequent musculoskeletal soft-tissue tumors

International Nuclear Information System (INIS)

Widmann, Gerlig; Riedl, Andreas; Schoepf, Daniel; Glodny, Bernhard; Peer, Siegfried; Gruber, Hannes

2009-01-01

High resolution ultrasound (HR-US) including color Doppler ultrasound (CD-US), power Doppler ultrasound (PD-US), and spectral wave analysis (SWA), is a broadly available, non-invasive and relatively low-cost modality without ionizing radiation. It is increasingly used for initial assessment of an ambiguous musculoskeletal soft-tissue lesion and for sonographically guided core biopsy. The aim of this review is to provide sonographic findings of the most frequent benign and malign soft-tissue lesions. By this essay, we can show that combined with clinical features, with information on tumor-localization and patient age, many musculoskeletal lesions may be successfully characterized by HR-US. In contrast, a mere morphologic assignment of some fibrous tumors and malignant lesions remains often impossible; however, certain CD-US signs such as anarchic vascular architecture or arteriovenous shunting may be very helpful indicators for malignancy. HR-US offers a simple, quick, and reliable first-line examination of musculoskeletal soft-tissue lesions and may have an important role in the diagnostic work-up followed by magnetic resonance or multimodality imaging and guided core biopsy. (orig.)

HR TRAINING PROGRAMS – CASE STUDY: WHAT ARE THE PARTICIPANTS’ EXPECTATIONS?

OpenAIRE

Abrudan Maria-Madela; Hatos Roxana; Matei Mirabela-Constanta

2010-01-01

When conducting a training program, training providers should ask themselves this question: What are the participants’ expectations? Training providers must correlate their programs with the needs and expectations of participants in order to be successful. Considering there is a need for the professionalization of human resources management activities, we focused our attention on three key occupations of HR: Human Resources Analyst, Human Resources Inspector and Human Resources Manager. To as...

The variable Herbig Ae star HR 5999: VIII. Spectroscopic observations 1975 - 1985 and correlations with simulataneous photometry

International Nuclear Information System (INIS)

Tjin, A.; Djie, H.R.E.; The, P.S.; Andersen, J.; Nordstroem, B.; Finkenzeller, U.; Jankovics, I.

1989-01-01

Visual spectroscopy of the irregularly variable Herbig Ae star HR 5999 over the past 15 years is summarised. The general features of the spectrum indicate that HR 5999 is an A5-7 III-IVe star with an extended circumstellar atmosphere. Typical lines have a rotationally broadened photospheric component and one or two blue-shifted ''shell'' components. The average radial velocity of the photospheric components, together with the common proper motions of the stars strongly suggest that HR 5999 and the peculiar B6 star HR 6000 from a physical pair, with common age. In order to study the relation between variations in the spectrum and in the brightness of the star, three sequences of simultaneous spectroscopic and photometric observations have been obtained during the past decade. From these and other (isolated) simultaneous observations we concluded that: (a) the photospheric radial velocity component is variable, possibly with a period of about 14 days, which could point to the presence of a close companion, (b) occasionally, sudden variations may occur (within one night) either in the photospheric line components,or in the shell (absorption or emission) components or both; (c) a decreasing brightness is correlated with increasing Hα-emission flux and a decreasing wind velocity in the shell region. An interpretation of these correlations in terms of magnetic activity is proposed

M-BAND IMAGING OF THE HR 8799 PLANETARY SYSTEM USING AN INNOVATIVE LOCI-BASED BACKGROUND SUBTRACTION TECHNIQUE

International Nuclear Information System (INIS)

Galicher, Raphael; Marois, Christian; Macintosh, Bruce; Konopacky, Quinn; Barman, Travis

2011-01-01

Multi-wavelength observations/spectroscopy of exoplanetary atmospheres are the basis of the emerging exciting field of comparative exoplanetology. The HR 8799 planetary system is an ideal laboratory to study our current knowledge gap between massive field brown dwarfs and the cold 5 Gyr old solar system planets. The HR 8799 planets have so far been imaged at J- to L-band, with only upper limits available at M-band. We present here deep high-contrast Keck II adaptive optics M-band observations that show the imaging detection of three of the four currently known HR 8799 planets. Such detections were made possible due to the development of an innovative LOCI-based background subtraction scheme that is three times more efficient than a classical median background subtraction for Keck II AO data, representing a gain in telescope time of up to a factor of nine. These M-band detections extend the broadband photometric coverage out to ∼5 μm and provide access to the strong CO fundamental absorption band at 4.5 μm. The new M-band photometry shows that the HR 8799 planets are located near the L/T-type dwarf transition, similar to what was found by other studies. We also confirm that the best atmospheric fits are consistent with low surface gravity, dusty, and non-equilibrium CO/CH 4 chemistry models.

Interface characteristic during bonding of Be and HR-1 stainless steel by hot pressing

International Nuclear Information System (INIS)

Li Hui; Kang Renmu; Zhou Shangqi; Kong Jilan; Zhang Pengcheng

2010-01-01

Be and HR-I stainless steel was diffusion bonded by hot pressing. The microstructure,composition and phase distribution and mechanical properties of the joints were analyzed using the optical microscopy, scanning electron microscopy(SEM), scanning auger microspectroscopy(SAM) and x-ray diffraction(XRD), and the effect of different interlayer materials Cu and Al and Ag-Cu alloy was also discussed. The results show that it is not easy to joint Be and HR-1 stainless when Al was used as the interlayer material, but good joints can be obtained using Cu and Ag and Cu alloy as the interlayer materials, because the formation of Be-Fe brittle intermetallic compounds was prevented. Ag-Cu alloy is the best interlayer materials among them, as it can reduce the mutual diffusion between Be and Fe. (authors)

STAR-BASED METHODS FOR PLEIADES HR COMMISSIONING

Directory of Open Access Journals (Sweden)

S. Fourest

2012-07-01

Full Text Available PLEIADES is the highest resolution civilian earth observing system ever developed in Europe. This imagery program is conducted by the French National Space Agency, CNES. It has been operating since 2012 a first satellite PLEIADES-HR launched on 2011 December 17th, a second one should be launched by the end of the year. Each satellite is designed to provide optical 70 cm resolution colored images to civilian and defense users. Thanks to the extreme agility of the satellite, new calibration methods have been tested, based on the observation of celestial bodies, and stars in particular. It has then been made possible to perform MTF measurement, re-focusing, geometrical bias and focal plane assessment, absolute calibration, ghost images localization, micro-vibrations measurement, etc… Starting from an overview of the star acquisition process, this paper will discuss the methods and present the results obtained during the first four months of the commissioning phase.

Draft genome sequence of a human-associated isolate of Haloferax alexandrinus strain Arc-hr, an extremely halophilic archaea.

Science.gov (United States)

Khelaifia, S; Caputo, A; Djossou, F; Raoult, D

2017-01-01

We report the draft genome sequence of Haloferax alexandrinus strain Arc-hr (CSUR P798), isolated from the human gut of a 10-year-old Amazonian individual. Its 3 893 626 bp genome exhibits a 66.00% GC content. The genome of the strain Arc-hr contains 37 genes identified as ORFans, seven genes associated to halocin and 11 genes associated with polyketide synthases or nonribosomal peptide synthetases.

DOE regulation of mixed waste. Hearing before the Subcommittee on Energy Conservation and Power and the Subcommittee on Commerce, Transportation, and Tourism of the Committee on Energy and Commerce, House of Representatives, Ninety-Ninth Congress, Second Session on H.R. 2009 and H.R. 2593, April 10, 1986

International Nuclear Information System (INIS)

Anon.

1986-01-01

Testimony by representatives of the Environmental Protection Agency, citizen environmental organizations, DOE, and universities on the Mixed Hazardous Waste Amendment Act of 1985 (H.R. 2009) and the Military Radioactive Emissions Control Act of 1985 (H.R. 2593) focused on safety aspects of mixed wastes at DOE facilities from the point of view of the general public and the implications for tourism and recreation in affected areas. H.R. 2593 calls for standards and continuous independent monitoring, while H.R. 2009 ensures that wastes the Solid Waste Management Act covers solid wastes containing radioactive material. The testimony covered definitions and interpretations by byproduct material and the problems associated with self-regulation. The testimony of the 10 witnesses follows the text of the two bills

Determination of rhenium traces in river water by Q-ICP-MS and HR-ICP-MS

International Nuclear Information System (INIS)

Uchida, S.; Tagami, K.; Saito, M.

2003-01-01

A simple separation method was applied to determine rhenium in river water using Q-ICP-MS and HR-ICP-MS. Re was concentrated from 420-925 ml river water using a TEVA resin minicolumn. Such extraction using a resin could separate Re from most sample matrices and trace elements. Almost 100% recovery was found throughout the method as determined with radioactive multitracers. The HR-ICP-MS was also used for the direct determination because of its low detection limit for Re (0.007 pg/ml). The Re concentration in the river water samples ranged from 0.9 to 6.5 pg/ml and the three analysis results showed good agreement with each other. (author)

Organizations' ways of employing early retirees: the role of age-based HR policies

NARCIS (Netherlands)

Oude Mulders, J.; Henkens, K.; Schippers, J.

2015-01-01

Purpose of the Study: We examine whether from an organizational perspective it is possible to distinguish different ways of employing early retirees and explore how the employment of early retirees is related to the application of 4 age-based human resource (HR) policies, namely demotion, offering

Organizations' Ways of Employing Early Retirees : The Role of Age-Based HR Policies

NARCIS (Netherlands)

Oude Mulders, Jaap; Henkens, Kène; Schippers, Joop

PURPOSE OF THE STUDY: We examine whether from an organizational perspective it is possible to distinguish different ways of employing early retirees and explore how the employment of early retirees is related to the application of 4 age-based human resource (HR) policies, namely demotion, offering

Operating characteristics of a 0.87 kW-hr flywheel energy storage module

Science.gov (United States)

Loewenthal, S. H.; Scibbe, H. W.; Parker, R. D.; Zaretsky, E. V.

1985-01-01

Discussion is given of the design and loss characteristics of 0.87 kW-hr (peak) flywheel energy storage module suitable for aerospace and automotive applications. The maraging steel flywheel rotor, a 46-cm- (18-in-) diameter, 58-kg (128-lb) tapered disk, delivers 0.65 kW-hr of usable energy between operating speeds of 10,000 and 20,000 rpm. The rotor is supported by 20- and 25-mm bore diameter, deep-groove ball bearings, lubricated by a self-replenishing wick type lubrication system. To reduce aerodynamic losses, the rotor housing was evacuated to vacuum levels from 40 to 200 millitorr. Dynamic rotor instabilities uncovered during testing necessitated the use of an elastometric-bearing damper to limit shaft excursions. Spindown losses from bearing, seal, and aerodynamic drag at 50 millitorr typically ranged from 64 to 193 W at 10,000 and 20,000 rpm, respectively. Discharge efficiency of the flywheel system exceeded 96 percent at torque levels greater than 21 percent of rated torque.

Measurement of 24-hr whole-body retention of sup(99m)Tc-MDP with a thyroid uptake probe

International Nuclear Information System (INIS)

Seto, Hikaru; Kakishita, Masao; Futatsuya, Ryusuke

1981-01-01

A new method for measurement of 24-hr whole-body retention (WBR) of sup(99m)Tc-MDP, using a thyroid uptake probe was established and its clinical significance was evaluated in various bone diseases. (1) Reproducibility of 24-hr WBR in 9 patients was very good. Correlation coefficient was 0.997 and coefficient of variability was only 1.83%. (2) Radiochemical purity of sup(99m)Tc-MDP was 97.8 +- 0.7% (n = 5), indicating no significant inter-lot variations. (3) 24-hr WBR of normal adult males (n = 5) was 30.0 +- 4.9%, which was significantly elevated compared to the reported sup(99m)Tc-HEDP WBR of 19.2 +- 1.7%. Whole-body retentions of chronic renal failure, metastatic bone disease and hyperthyroidism groups were significantly elevated compared to that of the normal group. However, WBR of steroid-induced osteoporotic group was significantly decreased. Based on these results, this thyroid uptake probe method was simple, reproducible and accurate to measure 24-hr WBR of sup(99m)Tc-MDP. Quantification of WBR of sup(99m)Tc-MDP was of great clinical value to diagnose metabolic bone disease and to follow-up metabolic and metastatic bone diseases. (author)

Inactivation of the HR6B ubiquitin-conjugating DNA repair enzyme in mice causes male sterility associated with chromatin modification.

NARCIS (Netherlands)

J. van Klaveren; J. de Wit (Jan); C.G. van Gurp; M.H.M. Koken (Marcel); M. Vermey; J.H. van Roijen (Jan Herman); J.T.M. Vreeburg (Jan); W.M. Baarends (Willy); D. Bootsma (Dirk); J.A. Grootegoed (Anton); J.H.J. Hoeijmakers (Jan); H.P. Roest (Henk)

1996-01-01

textabstractThe ubiquitin-conjugating yeast enzyme RAD6 and its human homologs hHR6A and hHR6B are implicated in postreplication repair and damage-induced mutagenesis. The yeast protein is also required for sporulation and may modulate chromatin structure via histone ubiquitination. We report the

Redesain Pasar Pagi Jalan HR. Soebrantas Pekanbaru dengan Pendekatan Arsitektur Tropis

OpenAIRE

', Asmadi '; Hidayat, Wahyu '; Rijal, Muhammad '

2014-01-01

Pasar Pagi located in HR.Soebrantas street takes an imfortant role in fulfilling the needs of the society surroundings, completely to the economic social order. Considering the unsuppported services faced in these public facilities; frequently traffic congestion, insufficient parking space, poor drainage system, and incompletely arranged market spot, redesigning of the Pasar Pagi is a significance to overcome the cases exist. The design method undertaken prior to the project uses the principl...

H.R. 3236 and H.R. 4458, bills affecting veterans exposed to ionizing radiation in military service. Hearing before the Subcommittee on Compensation, Pension and Insurance of the Committee on Veteran's Affairs, House of Representatives, One Hundred Second Congress, Second Session, May 27, 1992

International Nuclear Information System (INIS)

Anon.

1992-01-01

The hearing addresses H.R. 3236 and H.R. 4458 bills affecting veterans exposed to ionizing radiation in military service. The bills authorized treatment and provide benefits to military veterans who have been adversely affected by exposure to radioactive materials. Statements of government and industry officials are included along with documents submitted for the record

Can human resources induce sustainability in business?: Modeling, testing and correlating HR index and company's business results

Directory of Open Access Journals (Sweden)

Zubović Jovan

2015-01-01

Full Text Available Abstract In this paper the authors analyze the impact of the composite human resource index on sustainable growth in a specific business sector in a transition country. Sustainability of country's economy is growingly relying on the knowledge economy which has been implemented in strategies of sustainable development throughout Europe. The knowledge economy is mostly based on human resources and the way they are organized and managed in the companies actively operating in competitive markets. In order to confirm importance of the human resources (HR index, results were tested by means of modeling, measuring and correlating the HR index with business results at micro level. The tests were conducted on the data from the survey in Serbian meat processing industry. The results were then compared with the results from the survey conducted in a financial industry. Moreover, a model was made that could be applicable in all countries that do not have available official statistic data on the level of investments in human resources. The focus was on determining the correlation direction, and hence creating a research model applicable in all business sectors. It has been found that a significant one-way correlation exists between business performance and increased HR index. In that way it has been confirmed that in Serbian economy that has recorded global decrease during transition, certain business sectors, and especially companies with high levels of investments in improving its HR index record above average and sustainable growth.

Computational identification, characterization and validation of potential antigenic peptide vaccines from hrHPVs E6 proteins using immunoinformatics and computational systems biology approaches.

Directory of Open Access Journals (Sweden)

Abbas Khan

Full Text Available High-risk human papillomaviruses (hrHPVs are the most prevalent viruses in human diseases including cervical cancers. Expression of E6 protein has already been reported in cervical cancer cases, excluding normal tissues. Continuous expression of E6 protein is making it ideal to develop therapeutic vaccines against hrHPVs infection and cervical cancer. Therefore, we carried out a meta-analysis of multiple hrHPVs to predict the most potential prophylactic peptide vaccines. In this study, immunoinformatics approach was employed to predict antigenic epitopes of hrHPVs E6 proteins restricted to 12 Human HLAs to aid the development of peptide vaccines against hrHPVs. Conformational B-cell and CTL epitopes were predicted for hrHPVs E6 proteins using ElliPro and NetCTL. The potential of the predicted peptides were tested and validated by using systems biology approach considering experimental concentration. We also investigated the binding interactions of the antigenic CTL epitopes by using docking. The stability of the resulting peptide-MHC I complexes was further studied by molecular dynamics simulations. The simulation results highlighted the regions from 46-62 and 65-76 that could be the first choice for the development of prophylactic peptide vaccines against hrHPVs. To overcome the worldwide distribution, the predicted epitopes restricted to different HLAs could cover most of the vaccination and would help to explore the possibility of these epitopes for adaptive immunotherapy against HPVs infections.

Proposed plan for interim remedial measures at the 100-HR-1 Operable Unit, Hanford Site, Richland, Washington. Draft A

International Nuclear Information System (INIS)

1994-09-01

This proposed plan introduces the interim remedial measures for addressing contaminated soil at the 100-HR-1 Operable Unit, located at the Hanford Site. In addition, this plan includes a summary of other alternatives analyzed and considered for the 100-HR-1 Operable Unit. The EPA, DOE, and Washington State Dept. of Ecology believe that a combination of removal, treatment, and disposal technologies, where appropriate, would significantly reduce the potential threats to human health and the environment at the 100-HR-1 Operable Unit high-priority waste sites. The remedial actions described in this proposed plan are designed to minimize human health and ecological risks and ensure that additional contaminants originating from these waste sites are not transported to the groundwater. The 100-HR-1 Operable Unit contains the retention basin for the H reactor cooling system, process effluent trenches, the Pluto crib which received an estimated 260 gallons of radioactive liquid waste, process effluent pipelines, and solid waste sites used for the burial of decontaminated and decommissioned equipment from other facilities. Potential health threats would be from the isotopes of cesium, cobalt, europium, plutonium, and strontium, and from chromium, arsenic, lead, and chysene

Getting People Involved: The Benefit of Intellectual Capital Management for Addressing HR Challenges

Science.gov (United States)

Pook, Katja

2011-01-01

Purpose: This paper aims to explore the benefits of intellectual capital assessment for facing current challenges of human resources work and organizational development. Design/methodology/approach: The paper takes findings of studies on challenges in HR work and maps them with features of intellectual capital assessment methods. It is thus a…

Creep properties of simulated heat-affected zone of HR3C austenitic steel

Czech Academy of Sciences Publication Activity Database

Sklenička, Václav; Kuchařová, Květa; Kvapilová, Marie; Svoboda, Milan; Král, Petr; Dvořák, Jiří

2017-01-01

Roč. 128, JUN (2017), s. 238-247 ISSN 1044-5803 R&D Projects: GA MŠk(CZ) LQ1601 Institutional support: RVO:68081723 Keywords : HR3C steel * Welding * Heat affected zone * Creep * Microstructure * Fractography Subject RIV: JG - Metallurgy OBOR OECD: Materials engineering Impact factor: 2.714, year: 2016

Selvitys HR House Oy:n vuokratyöntekijöiden työtyytyväisyydestä

OpenAIRE

Kaskela, Leeni

2011-01-01

Opinnäytetyön tarkoituksena oli selvittää HR House Oy:n palveluksessa olevien vuokratyöntekijöiden työtyytyväisyyteen vaikuttavia asioita. Opinnäytetyö on laadullinen tutkielma, jossa käytän tutkimusmenetelmänä teemahaastattelua. Tutkimuskysymykseni selvittävät, mitkä asiat vaikuttavat työntekijöiden työ- tyytyväisyyteen ja mitä he kertovat työtyytyväisyyteen vaikuttavista tekijöistä. Toimeksianto opinnäytetyön tekemiseen on tullut HR House Oy Henkilöstöpalveluilta. Tavoitteena oli löytää kei...

1+1=3 De kansen van samenwerking tussen wetenschap en praktijk bij HR analytics

NARCIS (Netherlands)

Charissa Freese; Sjoerd van den Heuvel

2017-01-01

Wanneer we over HRM en technologie spreken, kunnen we niet meer heen om HR analytics. Gefaciliteerd door de alsmaar groeiende hoeveelheid beschikbare data, oftewel Big Data, proberen organisaties momenteel volop waardevolle inzichten uit de bijna oneindige hoeveelheid data te genereren. Samenwerking

Team and teamwork in modern european HR management

Directory of Open Access Journals (Sweden)

Usheva Mariana

2016-06-01

Full Text Available One of the major issues occurring in every contemporary organization is the issue of the efficiency of work and obtaining maximum results from work done. Most often when the issue of increasing the efficiency of work is laid the question of teams and teamwork in various projectя of the company comes to the foreground and frequently no proper differentiation is made between a “group of people” and a “team” and this brings to a large number of misunderstandings of managers and employees with regard to the designation and benefits of team organization of work. There are clear traceable differences between the perception of the concept of “team” and the implementation of teamwork by European and Bulgarian companies and it is good to make the differentiation between them with a view to the HR management.

SPECTROSCOPIC AND PHOTOMETRIC VARIABILITY IN THE A0 SUPERGIANT HR 1040

International Nuclear Information System (INIS)

Corliss, David J.; Morrison, Nancy D.; Adelman, Saul J.

2015-01-01

A time-series analysis of spectroscopic and photometric observables of the A0 Ia supergiant HR 1040 has been performed, including equivalent widths, radial velocities, and Strömgren photometric indices. The data, obtained from 1993 through 2007, include 152 spectroscopic observations from the Ritter Observatory 1 m telescope and 269 Strömgren photometric observations from the Four College Automated Photoelectric Telescope. Typical of late B- and early A-type supergiants, HR 1040 has a highly variable Hα profile. The star was found to have an intermittent active phase marked by correlation between the Hα absorption equivalent width and blue-edge radial velocity and by photospheric connections observed in correlations to equivalent width, second moment and radial velocity in Si ii λλ6347, 6371. High-velocity absorption (HVA) events were observed only during this active phase. HVA events in the wind were preceded by photospheric activity, including Si ii radial velocity oscillations 19–42 days prior to onset of an HVA event and correlated increases in Si ii W λ and second moment from 13 to 23 days before the start of the HVA event. While increases in various line equivalent widths in the wind prior to HVA events have been reported in the past in other stars, our finding of precursors in enhanced radial velocity variations in the wind and at the photosphere is a new result

GPI Spectra of HR8799 C, D, and E in H-K Bands with KLIP Forward Modeling

Science.gov (United States)

Greenbaum, Alexandra Z.; Pueyo, Laurent; Ruffio, Jean-Baptiste; Wang, Jason J.; De Rosa, Robert J.; Aguilar, Jonathan; Rameau, Julien; Barman, Travis; Marois, Christian; Marley, Mark S.;

Upgrade de SAP ERP v4.6C a ERP 6.0 del módulo HR

OpenAIRE

Raya Vílchez, Abel

2008-01-01

El proyecto que se plantea realizar se centraría en el módulo de HR (Recursos Humanos) de SAPo Este módulo es totalmente diferente a los demás que proporciona SAPo Esto se debe a que fue un módulo que se introdujo a posteriori y que se realizó partiendo de los conocimientos de otras empresas que habían implantado software específico para estos departamentos. Así, uno de los principales puntos fuertes del proyecto será el análisis del módulo de HR. También nos centraremos en ...

Human recombinant cementum attachment protein (hrPTPLa/CAP) promotes hydroxyapatite crystal formation in vitro and bone healing in vivo.

Science.gov (United States)

Montoya, Gonzalo; Arenas, Jesús; Romo, Enrique; Zeichner-David, Margarita; Alvarez, Marco; Narayanan, A Sampath; Velázquez, Ulises; Mercado, Gabriela; Arzate, Higinio

2014-12-01

Cementum extracellular matrix is similar to other mineralized tissues; however, this unique tissue contains molecules only present in cementum. A cDNA of these molecules, cementum attachment protein (hrPTPLa/CAP) was cloned and expressed in a prokaryotic system. This molecule is an alternative splicing of protein tyrosine phosphatase-like A (PTPLa). In this study, we wanted to determine the structural and functional characteristics of this protein. Our results indicate that hrPTPLa/CAP contains a 43.2% α-helix, 8.9% β-sheet, 2% β-turn and 45.9% random coil secondary structure. Dynamic light scattering shows that this molecule has a size distribution of 4.8 nm and aggregates as an estimated mass of 137 kDa species. AFM characterization and FE-SEM studies indicate that this protein self-assembles into nanospheres with sizes ranging from 7.0 to 27 nm in diameter. Functional studies demonstrate that hrPTPLa/CAP promotes hydroxyapatite crystal nucleation: EDS analysis revealed that hrPTPLa/CAP-induced crystals had a 1.59 ± 0.06 Ca/P ratio. Further confirmation with MicroRaman spectrometry and TEM confirm the presence of hydroxyapatite. In vivo studies using critical-size defects in rat cranium showed that hrPTPLa/CAP promoted 73% ± 2.19% and 87% ± 1.97% new bone formation at 4 and 8 weeks respectively. Although originally identified in cementum, PTPLa/CAP is very effective at inducing bone repair and healing and therefore this novel molecule has a great potential to be used for mineralized tissue bioengineering and tissue regeneration. Copyright © 2014 Elsevier Inc. All rights reserved.

Magnetic field topology and chemical abundance distributions of the young, rapidly rotating, chemically peculiar star HR 5624

Science.gov (United States)

Kochukhov, O.; Silvester, J.; Bailey, J. D.; Landstreet, J. D.; Wade, G. A.

2017-09-01

Context. The young, rapidly rotating Bp star HR 5624 (HD 133880) shows an unusually strong non-sinusoidal variability of its longitudinal magnetic field. This behaviour was previously interpreted as the signature of an exceptionally strong, quadrupole-dominated surface magnetic field geometry. Aims: We studied the magnetic field structure and chemical abundance distributions of HR 5624 with the aim to verify the unusual quadrupolar nature of its magnetic field and to investigate correlations between the field topology and chemical spots. Methods: We analysed high-resolution, time series Stokes parameter spectra of HR 5624 with the help of a magnetic Doppler imaging inversion code based on detailed polarised radiative transfer modelling of the line profiles. Results: We refined the stellar parameters, revised the rotational period, and obtained new longitudinal magnetic field measurements. Our magnetic Doppler inversions reveal that the field structure of HR 5624 is considerably simpler and the field strength is much lower than proposed by previous studies. We find a maximum local field strength of 12 kG and a mean field strength of 4 kG, which is about a factor of three weaker than predicted by quadrupolar field models. Our model implies that overall large-scale field topology of HR 5624 is better described as a distorted, asymmetric dipole rather than an axisymmetric quadrupole. The chemical abundance maps of Mg, Si, Ti, Cr, Fe, and Nd obtained in our study are characterised by large-scale, high-contrast abundance patterns. These structures correlate weakly with the magnetic field geometry and, in particular, show no distinct element concentrations in the horizontal field regions predicted by theoretical atomic diffusion calculations. Conclusions: We conclude that the surface magnetic field topology of HR 5624 is not as unusual as previously proposed. Considering these results together with other recent magnetic mapping analyses of early-type stars suggests that

Impact of H.R practices on employee’s job satisfaction: A case study from fertilizer industry of Pakistan

Directory of Open Access Journals (Sweden)

Afzal Ahmed

2017-05-01

Full Text Available This study investigates the impact of human resources (HR practices, recruitment and selection, training and development, compensation and benefits, on employee’s job satisfaction in fertilizer sector of Pakistan. A pre-tested questionnaire was distributed and two hundred respondents pro-vided useable information. The result of the study shows a positive relationship between HR practices and job performance, which indicates fair recruitment and selection, better training and development opportunities and attractive compensation and benefit packages increase the level of satisfaction of employees.

PopHR: a knowledge-based platform to support integration, analysis, and visualization of population health data.

Science.gov (United States)

Shaban-Nejad, Arash; Lavigne, Maxime; Okhmatovskaia, Anya; Buckeridge, David L

2017-01-01

Population health decision makers must consider complex relationships between multiple concepts measured with differential accuracy from heterogeneous data sources. Population health information systems are currently limited in their ability to integrate data and present a coherent portrait of population health. Consequentially, these systems can provide only basic support for decision makers. The Population Health Record (PopHR) is a semantic web application that automates the integration and extraction of massive amounts of heterogeneous data from multiple distributed sources (e.g., administrative data, clinical records, and survey responses) to support the measurement and monitoring of population health and health system performance for a defined population. The design of the PopHR draws on the theories of the determinants of health and evidence-based public health to harmonize and explicitly link information about a population with evidence about the epidemiology and control of chronic diseases. Organizing information in this manner and linking it explicitly to evidence is expected to improve decision making related to the planning, implementation, and evaluation of population health and health system interventions. In this paper, we describe the PopHR platform and discuss the architecture, design, key modules, and its implementation and use. © 2016 New York Academy of Sciences.

The effect of individual HR domains on financial performance : Evidence from Belgian small businesses

NARCIS (Netherlands)

Faems, D; Sels, L; De Winne, S; Maes, J

2005-01-01

The contribution of this study, which assesses the influence of HRM on financial performance, is fourfold. (1) We assess the relative contribution of different HR domains to organizational performance. By controlling for the overall HRM intensity in all analyses we try to meet one of the most

Effect of hrHPV infection on anti-apoptotic gene and pro-apoptotic gene expression in cervical cancer tissue

Directory of Open Access Journals (Sweden)

Min-Er Tang

2016-09-01

Full Text Available Objective: To study the effect of hrHPV infection on anti-apoptotic gene and pro-apoptotic gene expression in cervical cancer tissue. Methods: A total of 56 patients with cervical cancer, 94 cases of patients with cervical intraepithelial neoplasia and 48 cases of patients with chronic cervicitis who were treated in our hospital from May 2013 to December 2015 were selected for study and included in malignant group, precancerous lesion group and benign group respectively. hrHPV infection as well as the expression of anti-apoptotic genes and proapoptotic genes in cervical tissue were detected. Results: hrHPV infection rate and viral load in cervical tissue of malignant group were significantly higher than those of precancerous lesion group and benign group; P27 and p16 levels in cervical tissue of malignant group were significantly lower than those of precancerous lesion group and benign group, and K-ras, c-myc, Prdx4 and TNFAIP8 levels were significantly higher than those of precancerous lesion group and benign group; the greater the HPV virus load, the lower the p27 and p16 levels and the higher the K-ras, c-myc, Prdx4 and TNFAIP8 levels in cervical tissue. Conclusions: hrHPV infection can result in tumor suppressor genes p27 and p16 expression deletion and increase the expression of proto-oncogene and apoptosis-inhibiting genes, and it is associated with the occurrence and development of cervical cancer.

Federal Pay Equity Act of 1984. Part 1. Hearings before the Subcommittee on Compensation and Employee Benefits of the Committee on Post Office and Civil Service, House of Representatives, Ninety-Eighth Congress, Second Session on H.R. 4599...and H.R. 5092. (April 3-4, 1984).

Science.gov (United States)

Congress of the U. S., Washington, DC. House Committee on Post Office and Civil Service.

This document contains two congressional hearings on H.R. 4599, the Federal Pay Equity Act of 1984, and H.R. 5092, the Pay Equity Act of 1984. These bills would mandate the Office of Personnel Management to study wage discrepancies in the Federal classification structure and to devise a more equitable job evaluation program and would require…

Commercialization of Children's Television. Hearings on H.R. 3288, H.R. 3966, and H.R. 4125: Bills To Require the FCC To Reinstate Restrictions on Advertising during Children's Television, To Enforce the Obligation of Broadcasters To Meet the Educational Needs of the Child Audience, and for Other Purposes, before the Subcommittee on Telecommunications and Finance of the Committee on Energy and Commerce, House of Representatives, One Hundredth Congress (September 15, 1987 and March 17, 1988).

Science.gov (United States)

Congress of the U.S., Washington, DC. House Committee on Energy and Commerce.

This report provides transcripts of two hearings held 6 months apart before a subcommittee of the House of Representatives on three bills which would require the Federal Communications Commission to reinstate restrictions on advertising on children's television programs. The texts of the bills under consideration, H.R. 3288, H.R. 3966, and H.R.…

Characterization of hairless (Hr) and FGF5 genes provides insights into the molecular basis of hair loss in cetaceans.

Science.gov (United States)

Chen, Zhuo; Wang, Zhengfei; Xu, Shixia; Zhou, Kaiya; Yang, Guang

2013-02-09

Hair is one of the main distinguishing characteristics of mammals and it has many important biological functions. Cetaceans originated from terrestrial mammals and they have evolved a series of adaptations to aquatic environments, which are of evolutionary significance. However, the molecular mechanisms underlying their aquatic adaptations have not been well explored. This study provided insights into the evolution of hair loss during the transition from land to water by investigating and comparing two essential regulators of hair follicle development and hair follicle cycling, i.e., the Hairless (Hr) and FGF5 genes, in representative cetaceans and their terrestrial relatives. The full open reading frame sequences of the Hr and FGF5 genes were characterized in seven cetaceans. The sequence characteristics and evolutionary analyses suggested the functional loss of the Hr gene in cetaceans, which supports the loss of hair during their full adaptation to aquatic habitats. By contrast, positive selection for the FGF5 gene was found in cetaceans where a series of positively selected amino acid residues were identified. This is the first study to investigate the molecular basis of the hair loss in cetaceans. Our investigation of Hr and FGF5, two indispensable regulators of the hair cycle, provide some new insights into the molecular basis of hair loss in cetaceans. The results suggest that positive selection for the FGF5 gene might have promoted the termination of hair growth and early entry into the catagen stage of hair follicle cycling. Consequently, the hair follicle cycle was disrupted and the hair was lost completely due to the loss of the Hr gene function in cetaceans. This suggests that cetaceans have evolved an effective and complex mechanism for hair loss.

Feminisation of the medical profession: a strategic HRM dilemma? The effects of family-friendly HR practices on female doctors' contracted working hours

NARCIS (Netherlands)

Pas, B.R.; Peters, P.; Doorewaard, J.A.C.M.; Eisinga, R.N.; Lagro-Janssen, A.L.M.

2011-01-01

Health-care institutions face a strategic HR dilemma. They need to attract female doctors from a tight, feminised labour market by offering family-friendly HR practices (e.g. part-time employment), often based on collective labour agreements, while trying to contain their labour costs by employing

Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis.

Science.gov (United States)

Burghardt, Andrew J; Lee, Chan Hee; Kuo, Daniel; Majumdar, Sharmila; Imboden, John B; Link, Thomas M; Li, Xiaojuan

2013-12-01

In this technique development study, high-resolution peripheral quantitative computed tomography (HR-pQCT) was applied to non-invasively image and quantify 3D joint space morphology of the wrist and metacarpophalangeal (MCP) joints of patients with rheumatoid arthritis (RA). HR-pQCT imaging (82 μm voxel-size) of the dominant hand was performed in patients with diagnosed rheumatoid arthritis (RA, N = 16, age: 52.6 ± 12.8) and healthy controls (CTRL, N = 7, age: 50.1 ± 15.0). An automated computer algorithm was developed to segment wrist and MCP joint spaces. The 3D distance transformation method was applied to spatially map joint space width, and summarized by the mean joint space width (JSW), minimal and maximal JSW (JSW.MIN, JSW.MAX), asymmetry (JSW.AS), and distribution (JSW.SD)-a measure of joint space heterogeneity. In vivo precision was determined for each measure by calculating the smallest detectable difference (SDD) and root mean square coefficient of variation (RMSCV%) of repeat scans. Qualitatively, HR-pQCT images and pseudo-color JSW maps showed global joint space narrowing, as well as regional and focal abnormalities in RA patients. In patients with radiographic JSN at an MCP, JSW.SD was two-fold greater vs. CTRL (p 3D joint space morphology from HR-pQCT, could improve early detection of joint damage in rheumatological diseases.

HR-MAS NMR for rapid identification of illicit substances in tablets and Blotter papers seized by Police Department

International Nuclear Information System (INIS)

Souza, Luciano F.; Vieira, Tarcísio S.; Lião, Luciano M.; Alcantara, Glaucia B.

2016-01-01

Illicit substances found in blotter papers and tablets seized by police are traditionally identified and characterized from extracts of these materials. However, the procedures involved in extraction stages can result in artifacts and even contamination of the samples to be analyzed. On the other hand, high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) is a technique that requires no pretreatment steps, enabling direct analysis of the material, including the analysis of new illegal synthetic psychoactive substances. This study presents and discusses applications of the HR-MAS NMR in the analysis of tablets and blotter papers seized. Additional analysis in solution of the extracts of these materials was performed to compare the obtained spectral resolution signals. The results demonstrated that the HR-MAS NMR allowed the rapid identification of 3,4-methylenedioxy-N-methylcathinone (methylone), 4-methylmethcathinone (mephedrone), 2,5-dimethoxy-4-bromoamphetamine (DOB) and 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2- methoxyphenyl)methyl]ethanamine (25B-NBOMe) in samples of tablets and blotter papers seized in Goiás State, Brazil. (author)

HR-MAS NMR for rapid identification of illicit substances in tablets and Blotter papers seized by Police Department

Energy Technology Data Exchange (ETDEWEB)

Souza, Luciano F.; Vieira, Tarcísio S.; Lião, Luciano M., E-mail: lucianoliao@ufg.br [Universidade Federal de Goiás (UFG), Goiânia, GO (Brazil). Instituto de Química; Alcantara, Glaucia B. [Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, MS (Brazil). Instituto de Química

2016-07-01

Illicit substances found in blotter papers and tablets seized by police are traditionally identified and characterized from extracts of these materials. However, the procedures involved in extraction stages can result in artifacts and even contamination of the samples to be analyzed. On the other hand, high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) is a technique that requires no pretreatment steps, enabling direct analysis of the material, including the analysis of new illegal synthetic psychoactive substances. This study presents and discusses applications of the HR-MAS NMR in the analysis of tablets and blotter papers seized. Additional analysis in solution of the extracts of these materials was performed to compare the obtained spectral resolution signals. The results demonstrated that the HR-MAS NMR allowed the rapid identification of 3,4-methylenedioxy-N-methylcathinone (methylone), 4-methylmethcathinone (mephedrone), 2,5-dimethoxy-4-bromoamphetamine (DOB) and 2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2- methoxyphenyl)methyl]ethanamine (25B-NBOMe) in samples of tablets and blotter papers seized in Goiás State, Brazil. (author)

India's first 100,000 lbs/hr atmospheric bed boiler

International Nuclear Information System (INIS)

Mahajan, S.K.

1991-01-01

This paper covers the operating experience at the Petrochemical Complex of Hindustan Polymers, a Member Company of the UB Group, India, on the India's first 100,000 Lbs/hr atmospheric fluidized bed boiler supplied by Bharat Heavy Electricals Ltd., India. This atmospheric fluidized bed boiler is in operation for over 7 years with over 51,000 operating hours. The paper covers the details of onstream hours, actual thermal efficiency achieved, type of coal used and operational advantages of such boilers as per experience of Hindustan Polymers. Paper also highlights the maintenance and equipment problems as well as the developments which have taken place to overcome such problems. Details of experience in the operation of this boiler with baghouse system using abrasive and high ash coal are also covered

Low-cycle fatigue deformation characteristics of Haynes {reg{underscore}sign} HR-120{reg{underscore}sign} alloy

Energy Technology Data Exchange (ETDEWEB)

Liaw, P.K.; He, Y.H.; Miller, L.; Huang, M.; Brooks, C.R.; Seeley, R.R.; Klarstrom, D.L.

1999-07-01

Low-cycle fatigue deformation characteristics of HAYNES HR-120 alloy at room and high temperatures were studied under axial strain control. Test results show that there is a significant effect of test temperature on the low-cycle fatigue behavior of HAYNES HR-120 alloy. It was found that the alloy could cyclically harden at moderately high temperatures (649 C and 871 C), but generally cyclically soften at room temperature (24 C) and high temperature (982 C). However, the variation of the stress amplitude with cycles at the temperatures of 24 C and 982 C depended on the total strain range. The significant cyclic hardening of the alloy occurred at the high total strain ranges of 1.5% and 2.0% during the beginning state of the test at both 24C and 982 C. Microstructural analyses indicated that the cyclic hardening behavior of the alloy at the test temperature of 649 C could be related to the formation of a number of deformation bands. Nevertheless, increasing the test temperature to 871 C, cyclic hardening was attributed to the precipitation of secondary-phase particles. Furthermore, it was also found that the coarsening of secondary-phase particles brought about cyclic softening of the alloy at the high temperature of 982 C. Coffin-Manson equations and Holloman equations were given for HAYNES HR-120 alloy at different temperatures.

A 24 hr global campaign to assess precision timing of the millisecond pulsar J1713+0747

Energy Technology Data Exchange (ETDEWEB)

Dolch, T.; Lam, M. T.; Cordes, J.; Chatterjee, S. [Astronomy Department, Cornell University, Ithaca, NY 14853 (United States); Bassa, C.; Hessels, J. W. T.; Janssen, G.; Kondratiev, V. [ASTRON, the Netherlands Institute for Radio Astronomy, Postbus 2, 7990 AA, Dwingeloo (Netherlands); Bhattacharyya, B.; Jordan, C.; Keith, M. [Jodrell Bank Centre for Astrophysics, School of Physics and Astronomy, The University of Manchester, Manchester M13 9PL (United Kingdom); Champion, D. J.; Karuppusamy, R.; Kramer, M.; Lazarus, P. [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Cognard, I. [Laboratoire de Physique et Chimie de l' Environnement et de l' Espace, LPC2E UMR 6115 CNRS, F-45071 Orléans Cedex 02, and Station de radioastronomie de Nançay, Observatoire de Paris, CNRS/INSU, F-18330 Nançay (France); Crowter, K. [Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T 1Z1 (Canada); Demorest, P. B. [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22901 (United States); Jenet, F. A. [Center for Advanced Radio Astronomy, University of Texas, Rio Grande Valley, Brownsville, TX 78520 (United States); Jones, G., E-mail: tdolch@astro.cornell.edu [Columbia Astrophysics Laboratory, Columbia University, NY 10027 (United States); and others

2014-10-10

The radio millisecond pulsar J1713+0747 is regarded as one of the highest-precision clocks in the sky and is regularly timed for the purpose of detecting gravitational waves. The International Pulsar Timing Array Collaboration undertook a 24 hr global observation of PSR J1713+0747 in an effort to better quantify sources of timing noise in this pulsar, particularly on intermediate (1-24 hr) timescales. We observed the pulsar continuously over 24 hr with the Arecibo, Effelsberg, GMRT, Green Bank, LOFAR, Lovell, Nançay, Parkes, and WSRT radio telescopes. The combined pulse times-of-arrival presented here provide an estimate of what sources of timing noise, excluding DM variations, would be present as compared to an idealized √N improvement in timing precision, where N is the number of pulses analyzed. In the case of this particular pulsar, we find that intrinsic pulse phase jitter dominates arrival time precision when the signal-to-noise ratio of single pulses exceeds unity, as measured using the eight telescopes that observed at L band/1.4 GHz. We present first results of specific phenomena probed on the unusually long timescale (for a single continuous observing session) of tens of hours, in particular interstellar scintillation, and discuss the degree to which scintillation and profile evolution affect precision timing. This paper presents the data set as a basis for future, deeper studies.

Creep strength and microstructure in 23Cr-45Ni-7W Alloy (HR6W) and Ni-base superalloys for advanced USC boilers

Energy Technology Data Exchange (ETDEWEB)

Semba, Hiroyuki; Okada, Hirokazu; Yonemura, Mitsuharu; Igarashi, Masaaki [Sumitomo metal Industries, Ltd., Hyogo (Japan). Corporate Research and Development Labs.

2008-07-01

Establishment of materials technologies on piping and tubing for advanced ultra super critical (A-USC) plants operated at steam temperatures above 700 C is a critical issue to achieve its hard target. 23Cr-45Ni-7W alloy (HR6W) has been developed in Japan, originally as a high strength tubing material for 650 C USC boilers. In order to clarify the capability of HR6W as a material applied to A-USC plants, creep strength and microstructure of HR6W were investigated in comparison with {gamma}'-strengthened Alloy 617 and other Ni-base superalloys, such as Alloy 263. It has been revealed that the amount of added W is intimately correlated with precipitation amount of Laves phase and thus it is a crucial factor controlling creep strength. Stability of long term creep strength and superior creep rupture ductility have been proved by creep rupture tests at 650-800 C up to 60000h. The 10{sup 5}h extrapolated creep rupture strengths are estimated to be 88MPa at 700 C and 64MPa at 750 C. Microstructural stability closely related with long term creep strength and toughness has also been confirmed by microstructural observations after creep tests and aging. Creep rupture strength of Alloy 617 has been found to be much higher than that of HR6W at 700 and 750 C, while comparable at 800 C. A thermodynamic calculation along with microstructural observation indicates that the amount of Laves phase in HR6W gradually decreases with increasing temperature, while that of {gamma}' in Alloy 617 rapidly decreases with increasing temperature and {gamma}' almost dissolves at 800 C. This may lead to an abrupt drop in creep strength of Alloy 617 above 750 C. Alloy 263, in which more {gamma}' precipitates than Alloy 617, shows much higher creep strength. However, it is suggested that inhomogeneous creep deformation is enhanced compared with HR6W and Alloy 617. Capability of HR6W as a material for A-USC plants was discussed in terms of creep properties, microstructural stability and other

The influence of age on the associations between HR practices and both affective commitment and job satisfaction: A meta-analysis

OpenAIRE

Kooij, T.A.M.; Jansen, P.G.W.; Dikkers, J.S.E.; de Lange, A.H.

2010-01-01

Research on the association between high commitment Human Resource (HR) practices and work-related outcomes at the individual level rarely focuses on age differences. To fill this knowledge gap, a meta-analysis has been conducted to examine how the relationships between the availability of high commitment HR practices, as perceived by employees, and affective commitment and job satisfaction change with age. Drawing on Selection, Optimization, and Compensation (SOC) theory and on Regulatory Fo...

Managing aging workers: a mixed methods study on bundles of HR practices for aging workers

NARCIS (Netherlands)

Kooij, Dorien T. A. M.; Jansen, Paul G. W.; Dikkers, Josje S. E.; de Lange, Annet H.

2014-01-01

Since abilities and motives change with age and common human resource (HR) practices might be less suitable for aging employees, scholars and practitioners are currently challenged to find new ways of managing aging workers and motivating them to continue working. Therefore, this mixed methods study

Performance evaluation of the whole-body PET scanner ECAT EXACT HR+

International Nuclear Information System (INIS)

Adam, L.E.; Zaers, J.; Ostertag, H.; Trojan, H.

1996-01-01

The performance parameters of the whole-body PET scanner ECAT EXACT HR + were determined following the standard proposed by the International Electrotechnical Commission (IEC). The tests were expanded by some measurements concerning the accuracy of the correction algorithms and the geometric fidelity of the reconstructed images. The scanner consists of 32 rings, each with 576 BGO detectors (4.05 x 4.39 x 30 mm 3 ) covering an axial field-of-view of 15.5 cm and a patient port of 56.2 cm. The transaxial resolution in the 2D (3D) mode is 4.5 (4.3) mm at the center. It increases to 8.9 (8.3) mm radially and to 5.8 (5.2) mm tangentially at a radial distance of r = 20 cm. The average axial resolution varies between 4.9 (4.1) mm FWHM at the center and 8.8 (8.1) mm at r = 20 cm. The system sensitivity for true events is 5.85 (26.4) cps/Bq/ml (measured with a 20 cm cylinder phantom). The 50% dead-time losses where reached for a true event count rate of 286 (500) kcps at an activity concentration of 74 (25) kBq/ml. The system scatter fraction is 0.24 (0.35). The correction algorithms work reliable, except for the 3D attenuation correction. The ECAT EXACT HR + has a good and nearly isotropic spatial resolution. Due to the small detector elements, however, it has a low slice sensitivity which is a limiting factor for image quality

Limited field investigation report for the 100-HR-1 Operable Unit

International Nuclear Information System (INIS)

1994-08-01

This limited field investigation (LFI) report summarizes the data collection and analysis activities conducted during the 100-HR-1 Source Operable Unit LFI and the associated qualitative risk assessment (QRA) (WHC 1993a), and makes recommendations on the continued candidacy of high-priority sites for interim remedial measures (IRM). The results and recommendations presented in this report are generally independent of future land use scenarios. A LFI Report is required, in accordance with the HPPS, when waste sites are to be considered for IRMs. The LFI is an integral part of the remedial investigation/feasibility study (RI/FS) or Resource Conservation and Recovery Act (RCRA) facility investigation/corrective measures study (RFI/CMS) and process and functions as a focused RI or RFI for selection of IRMs. The purpose of the report is to identify those sites that are recommended to remain as candidates for IRMs, provide a preliminary summary of site characterization studies, refine the conceptual model as needed, identify contaminant- and location-specific applicable or relevant and appropriate requirements (ARA), and provide a qualitative assessment of the risks associated with the sites. This assessment includes consideration of whether contaminant concentrations pose an unacceptable risk that warrants action through IRMs. The 100-HR-1 unit encompasses approximately 100 acres adjacent to the Columbia River shoreline. It contains waste units associated with the original plant facilities constructed to support the H Reactor. The area also contains evaporation basins which received liquid process wastes and nonroutine deposits of chemical wastes from the 300 Area, where fuel elements for the N Reactor were produced

Factors of Nonlinear-ultrasonic Detection and Its Application to HR3C Fireside Corrosion

Directory of Open Access Journals (Sweden)

QIN Peng

2016-11-01

Full Text Available Based on the discussion of the factors influencing the nonlinear ultrasonic testing, the feasibility of nondestructive evaluation of HR3C fireside corrosion was investigated using nonlinear ultrasonic testing. The results show that the number of pulse string is no more than 2df/c and the installation of Hanning window is helpful to reduce the disturbance of the system, in addition, the rough surface of the sample has a significant impact on the nonlinear parameter β. The nonlinear coefficient demonstrates a phased growth trend as corrosion time prolongs. At the initial stage of corrosion(within 50h,there are small increments within 20% in the nonlinear coefficient, however,the nonlinear coefficient β is increased obviously with the duration time to 150h. Compared with un-corroded sample, the amplification in the sample corroded for 200h reaches to 260%. The monotonous varieties in nonlinear coefficient are consistent with the aggravation of corrosion damage,hence,it is feasible to nondestructively evaluate HR3C fireside corrosion by means of ultrasonic nonlinear testing.

RCRA facility investigation/corrective measures study work plan for the 100-HR-1 operable unit, Hanford Site, Richland, Washington

International Nuclear Information System (INIS)

1992-09-01

Four areas of the Hanford Site (the 100, 200, 300, and 1100 Areas) have been included on the US. Environmental Protection Agency's (EPA's) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). Under the Hanford Federal Facility Agreement and Consent Order, signed by the Washington State Department of Ecology (Ecology), EPA, and the US Department of Energy (DOE), more than 1,000 inactive waste disposal and unplanned release sites on the Hanford Site have been grouped into a number of source and groundwater operable units. These operable units contain contamination in the form of hazardous waste, radioactive/hazardous mixed waste, and other CERCLA hazardous substances. This work plan and the attached supporting project plans establish the operable unit setting and the objectives, procedures, tasks, and schedule for conducting the RCRA facility investigation/corrective measures study (RFI/CMS) for the 100-HR-1 source operable unit. Source operable units include facilities and unplanned release sites that are potential sources of contamination. The 100-HR-3 operable unit underlies the D/DR and H Areas, the 600 Area between them, and the six source operable units these areas contain. The 100-HR-3 operable unit includes all contamination found in the aquifer soils and water within its boundary. Separate work plans have been initiated for the 100-HR-3 groundwater operable unit (DOE-RL 1992a) and the 100-DR-1 (DOE-RL 1992b) source operable units

Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer.

Science.gov (United States)

Hortobagyi, Gabriel N; Stemmer, Salomon M; Burris, Howard A; Yap, Yoon-Sim; Sonke, Gabe S; Paluch-Shimon, Shani; Campone, Mario; Blackwell, Kimberly L; André, Fabrice; Winer, Eric P; Janni, Wolfgang; Verma, Sunil; Conte, Pierfranco; Arteaga, Carlos L; Cameron, David A; Petrakova, Katarina; Hart, Lowell L; Villanueva, Cristian; Chan, Arlene; Jakobsen, Erik; Nusch, Arnd; Burdaeva, Olga; Grischke, Eva-Maria; Alba, Emilio; Wist, Erik; Marschner, Norbert; Favret, Anne M; Yardley, Denise; Bachelot, Thomas; Tseng, Ling-Ming; Blau, Sibel; Xuan, Fengjuan; Souami, Farida; Miller, Michelle; Germa, Caroline; Hirawat, Samit; O'Shaughnessy, Joyce

2016-11-03

The inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) could potentially overcome or delay resistance to endocrine therapy in advanced breast cancer that is positive for hormone receptor (HR) and negative for human epidermal growth factor receptor 2 (HER2). In this randomized, placebo-controlled, phase 3 trial, we evaluated the efficacy and safety of the selective CDK4/6 inhibitor ribociclib combined with letrozole for first-line treatment in 668 postmenopausal women with HR-positive, HER2-negative recurrent or metastatic breast cancer who had not received previous systemic therapy for advanced disease. We randomly assigned the patients to receive either ribociclib (600 mg per day on a 3-weeks-on, 1-week-off schedule) plus letrozole (2.5 mg per day) or placebo plus letrozole. The primary end point was investigator-assessed progression-free survival. Secondary end points included overall survival, overall response rate, and safety. A preplanned interim analysis was performed on January 29, 2016, after 243 patients had disease progression or died. Prespecified criteria for superiority required a hazard ratio of 0.56 or less with P<1.29×10 -5 . The duration of progression-free survival was significantly longer in the ribociclib group than in the placebo group (hazard ratio, 0.56; 95% CI, 0.43 to 0.72; P=3.29×10 -6 for superiority). The median duration of follow-up was 15.3 months. After 18 months, the progression-free survival rate was 63.0% (95% confidence interval [CI], 54.6 to 70.3) in the ribociclib group and 42.2% (95% CI, 34.8 to 49.5) in the placebo group. In patients with measurable disease at baseline, the overall response rate was 52.7% and 37.1%, respectively (P<0.001). Common grade 3 or 4 adverse events that were reported in more than 10% of the patients in either group were neutropenia (59.3% in the ribociclib group vs. 0.9% in the placebo group) and leukopenia (21.0% vs. 0.6%); the rates of discontinuation because of adverse events were 7.5% and 2

Legislation to amend the Nuclear Non-Proliferation Act of 1978. Hearings and markup before the Committee on Foreign Affairs and its Subcommittees on International Security and Scientific Affairs, and on International Economic Policy and Trade of the House of Representatives, Ninety-Seventh Congress, Second Session on H.R. 6032 and H.R. 6318, August 3, 10; September 8, 15; and December 14, 1982

International Nuclear Information System (INIS)

Anon.

1983-01-01

Witnesses evaluated the effectiveness of non-proliferation policies during five days of hearings on H.R. 6032 and H.R. 6318 amending the Nuclear Non-Proliferation Act (NNPA) of 1978. The objective is to retain US leadership in nuclear trade while strengthening restrictions that retard the proliferation of weapons-grade material. They examined the economic benefits of new policy initiatives which permit foreign countries to reprocess and recycle US-supplied fuel and permit US companies to export reprocessing technology. The 19 witnesses spoke for the nuclear industry, organizations involved in arms control, and the administration. The 30 appendices include the texts of H.R. 6032, H.R. 6318, and H.R. 7430 and other comments and materials submitted for the record

A count rate model for PET and its application to an LSO HR PLUS scanner

International Nuclear Information System (INIS)

Moisan, C.; Rogers, J.G.; Douglas, J.L.

1996-10-01

We present a count rate model for PET. Considering a standard 20 x 20 cm phantom in the field-of-view of a cylindrical septaless tomograph, the model computes the acceptance to prompt and random events from simple geometric considerations. Dead time factors at all stages of a typical event acquisition architecture are calculated from specified processing clock cycles. Validations of the model's predictions against the measured performances of the ECAT-953B and the EXACT HR PLUS are presented. The model is then used to investigate the benefit of using detectors made of LSO in the EXACT HR PLUS scanner geometry. The results indicate that in replacing BGO by the faster LSO, one can count on an increase of the peak noise-equivalent-count rate by a factor 2.2. This gain will be achieved by using a 5 nsec coincidence window, buckets operating on 128 nsec clock cycle, and front-end data acquisition that can sustain a total rate of 2.9 MHz. (authors)

Microstructure and Porosity of Laser-welded Dissimilar Material Joints of HR-2 and J75

Science.gov (United States)

Shen, Xianfeng; Teng, Wenhua; Zhao, Shuming; He, Wenpei

Dissimilar laser welding of HR-2 and J75 has a wide range of applications in high-and low-temperature hydrogen storage. The porosity distributions of the welded joints were investigated at different line energies, penetration status, and welding positions (1G, 2G, and 3G). The effect of the welding position on the welding appearance was evident only at high line energies because of the essential effect of gravity of the larger and longer dwelling molten pool. The porosity of the welded joints between the solutionised and aged J75 and HR-2 at the 3G position and partial penetration was located at the weld centre line, while the porosity at the 2G position with full penetration was distributed at the weld edges, which is consistent with the distribution of floating slag. Full keyhole penetration resulted in minimum porosity, partial penetration resulted in moderate porosity, and periodic molten pool penetration resulted in maximum porosity.

Domestic Uranium Industry and Enrichment Program. Hearings before the Subcommittee on Energy and Power of the Committee on Energy and Commerce, House of Representatives, One Hundredth Congress, Second Session on H.R. 4934 and H.R. 5181, July 28 and August 10, 1988

International Nuclear Information System (INIS)

Anon.

1989-01-01

H.R. 4934 is a bill to provide for a viable domestic uranium industry, to establish a program to fund reclamation and other remedial actions with respect to mill tailings at active uranium and thorium sites, to establish a wholly-owned Government corporation to manage the Nation's uranium enrichment enterprise, operating as a continuing, commercial enterprise on a profitable and efficient basis, and for other purposes. H.R. 5181 is a bill to provide for the establishment of a uranium enrichment corporation, and for other purposes. Statements are presented from federal and state government officials, industry officials, utility representatives, and concerned citizen associations

Determination of 241Am in sediments by isotope dilution high resolution inductively coupled plasma mass spectrometry (ID HR ICP-MS).

Science.gov (United States)

Agarande, M; Benzoubir, S; Bouisset, P; Calmet, D

2001-08-01

Trace levels (pg kg(-1)) of 241Am in sediments were determined by isotope dilution high resolution inductively coupled plasma mass spectrometry (ID HR ICP-MS) using a microconcentric nebulizer. 241Am was isolated from major elements like Ca and Fe by different selective precipitations. In further steps. Am was first separated from other transuranic elements and purified by anion exchange and extraction chromatography prior to the mass spectrometric measurements. The ID HR ICP-MS results are compared with isotope dilution alpha spectrometry.

1H High Resolution Magic-Angle Coil Spinning (HR-MACS µNMR Metabolic Profiling of whole Saccharomyces cervisiae cells: A Demonstrative Study

Directory of Open Access Journals (Sweden)

Alan eWong

2014-06-01

Full Text Available The low sensitivity of Nuclear Magnetic Resonance (NMR is its prime shortcoming compared to other analytical methods for metabolomic studies. It relies on large sample volume (30–50 µl for HR-MAS for rich metabolic profiling, hindering high-throughput screening especially when the sample requires a labor-intensive preparation or is a sacred specimen. This is indeed the case for some living organisms. This study evaluates a 1H HR-MAS approach for metabolic profiling of small volume (250 nl whole bacterial cells, Saccharomyces cervisiae, using an emerging micro-NMR technology: high-resolution magic-angle coil spinning (HR-MACS. As a demonstrative study for whole cells, we perform two independent metabolomics studies identifying the significant metabolites associated with osmotic stress and aging.

Hygroscopic Metamorphic 4D Pleats

Science.gov (United States)

Yang, Shu

There have been significant interests in morphing 2D sheets into 3D structures via programmed out-of-plane distortion, including bending, tilting, rotating, and folding as seen in recent origami and kirigami strategies. Hydrogel is one of the unique soft materials that can swell and shrink, thereby enabling real-time 4D motions in response to external stimuli, such as pH, temperature, and moisture. To achieve reliable folding behaviors, it often requires a large amount of water molecules or ions diffusing in and out of the hydrogel sheet, thus the entire sheet is immersed in an aqueous solution. Here, we demonstrate the design and folding of hierarchical pleats patterned from a combination of hydrophobic and hygroscopic materials, allowing us to spatially and locally control the water condensation induced by environmental humidity. In turn, we show out-of-plane deformation of the 2D sheets only in the patterned hygroscopic regions, much like the folding behaviors of many plants. By designing the dimension, geometry, and density of hygroscopic microstructures (as pixels) in the hydrophobic materials, we can display the enhanced water condensation together with the spatial guidance of obtained droplets as unified water-harvesting systems. When the water droplets become large enough, they roll off from the hierarchical sheet along the inclined plane that is programmed by the hygroscopic motion of hydrogel, and eventually wrapped by the folded sheet to keep them from evaporation. We acknowledge support from NSF/EFRI-ODISSEI, EFRI 13-31583.

HR Excellence in Research as an attribute of scientific institutions’ competitiveness

Directory of Open Access Journals (Sweden)

Jarosławska-Sobór Sylwia

2017-03-01

Full Text Available What plays a major role in the process of building the competitiveness of an organization is not just the ability to adapt to the changing conditions in the environment, but also acquiring characteristics distinguishing it, which make it possible to keep, or improve its position on the market. What may be such a handicap for a scientific unit is the HR Excellence in Research (HRE logo, which is awarded by the European Commission under the strategy “Human Resources Strategy for Researchers” (HRS4R. It is awarded to scientific institutions, which implement the rules of the „European Charter for Researchers” and the „Code of Conduct for the Recruitment of Researchers”, and thanks to this create a friendly work environment and opportunities for development. In 2015 Central Mining Institute (GIG took steps aimed at getting the HR Excellence in Research logo, which is supposed to boost the attractiveness of the institute for scientists and contribute to further development of science and achieving a better position on the market. In the article the results of an internal analysis, which includes research on the opinions of scientific and research employees of GIG concerning the existing practices and rules governing research at the institute, are discussed. As a result of the research a Report together with an Action Plan were drawn up. They are supposed to support the creation of a friendly environment for scientific work and transparent rules for recruiting scientific employees. Also, the article highlights the most important challenges which the institute has to face in order to fully implement the guidelines of HRE, which stimulate economic and personal development.

Focal plane AIT sequence: evolution from HRG-Spot 5 to Pleiades HR

Science.gov (United States)

Le Goff, Roland; Pranyies, Pascal; Toubhans, Isabelle

2017-11-01

Optical and geometrical image qualities of Focal Planes, for "push-broom" high resolution remote sensing satellites, require the implementation of specific means and methods for the AIT sequence. Indeed the geometric performances of the focal plane mainly axial focusing and transverse registration, are duly obtained on the basis of adjustment, setting and measurement of optical and CCD components with an accuracy of a few microns. Since the end of the 1970s, EADS-SODERN has developed a series of detection units for earth observation instruments like SPOT and Helios. And EADS-SODERN is now responsible for the development of the Pleiades High Resolution Focal Plane assembly. This paper presents the AIT sequences. We introduce all the efforts, innovative solutions and improvements made on the assembly facilities to match the technical evolutions and breakthrough of the Pleiades HR FP concept in comparison with the previous High Resolution Geometric SPOT 5 Focal Plane. The main evolution drivers are the implementation of strip filters and the realization of 400 mm continuous retinas. For Pleiades HR AIT sequence, three specific integration and measuring benches, corresponding with the different assembly stages, are used: a 3-D non-contact measurement machine for the assembly of detection module, a 3-D measurement machine for mirror integration on the main Focal Plane SiC structure, and a 3-D geometric coordinates control bench to focus detection module lines and to ensure they are well registered together.

RADIO ASTROMETRY OF THE CLOSE ACTIVE BINARY HR 5110

Energy Technology Data Exchange (ETDEWEB)

Abbuhl, E.; Mutel, R. L.; Lynch, C. [Department of Physics and Astronomy, University of Iowa, Van Allen Hall, Iowa City, Iowa 52242 (United States); Güedel, M. [Department of Astronomy, University of Vienna, Vienna (Austria)

2015-09-20

The close active binary HR 5110 was observed at six epochs over 26 days using a global very long baseline interferometry array at 15.4 GHz. We used phase referencing to determine the position of the radio centroid at each epoch with an uncertainty significantly smaller than the component separation. After correcting for proper motion and parallax, we find that the centroid locations of all six epochs have barycenter separations consistent with an emission source located on the KIV secondary, and not in an interaction region between the stars or on the F primary. We used a homogeneous power-law gyrosynchrotron emission model to reproduce the observed flux densities and fractional circular polarization. The resulting ranges of mean magnetic field strength and relativistic electron densities are of the order of 10 G and 10{sup 5} cm{sup −3}, respectively, in the source region.

Welding Metallurgy of Alloy HR-160

International Nuclear Information System (INIS)

DuPont, J.N.; Michael, J.R.; Newbury, B.D.

1999-01-01

The solidification behavior and resultant solidification cracking susceptibility of autogenous gas tungsten arc fusion welds in alloy HR-160 was investigated by Varestraint testing, differential thermal analysis, and various microstructural characterization techniques. The alloy exhibited a liquidus temperature of 1387 degC and initiated solidification by a primary L - γ reaction in which Ni, Si, and Ti segregated to the interdendritic liquid and Co segregated to the γ dendrite cores. Chromium exhibited no preference for segregation to the solid or liquid phase during solidification. Solidification terminated at ∼ 1162 degC by a eutectic-type L - [γ+ (Ni,Co) 16 (Ti,Cr) 6 Si 7 ] reaction. The (Ni,Co) 16 (Ti,Cr) 6 Si 7 phase is found to be analogous to the G phase which forms in the Ni-Ti-Si and Co-Ti-Si ternary systems, and similarities are found to exist between the solidification behavior of this commercial multicomponent alloy and the simple Ni-Si and Ni-Ti binary systems. Reasonable agreement is obtained between the calculated and measured volume percent of the [γ +(Ni,Co) l6 (Ti,Cr) 6 Si 7 ] eutectic-typr constituent with the Scheil equation using experimentally determined k values for Si and Ti from electron microprobe data. The alloy exhibited a very high susceptibility to solidification cracking in the Varestraint test. This is attributed to a large solidification temperature range of 225 degC and the presence of 2 to 5 vol% solute rich interdendritic liquid which preferentially wets the grain boundaries and interdendritic regions

Bone Geometry, Volumetric Density, Microarchitecture and Estimated Bone Strength Assessed by HR-pQCT in Adult Patients with Hypophosphatemic Rickets

DEFF Research Database (Denmark)

Shanbhogue, Vikram Vinod; Hansen, Stinus; Folkestad, Lars

2015-01-01

Hypophosphatemic rickets (HR) is characterized by a generalized mineralization defect. Although densitometric studies have found the patients to have an elevated bone mineral density (BMD), data on bone geometry and microstructure are scarce. The aim of this cross-sectional in vivo study was to a......Hypophosphatemic rickets (HR) is characterized by a generalized mineralization defect. Although densitometric studies have found the patients to have an elevated bone mineral density (BMD), data on bone geometry and microstructure are scarce. The aim of this cross-sectional in vivo study...

HR-TEM and FT-Raman dataset of the caffeine interacted Phe–Phe peptide nanotube for possible sensing applications

Directory of Open Access Journals (Sweden)

A. Lakshmi Narayanan

2018-02-01

Full Text Available Sensing ability of caffeine interaction with Phe-Phe annotates (PNTs, is presented (Govindhan et al., 2017; Karthikeyan et al., 2014; Tavagnacco et al., 2013; Kennedy et al., 2011; Wang et al., 2017 [1–5] in this data set. Investigation of synthesized caffeine carrying peptide nanotubes are carried out by FT-Raman spectral analysis and high resolution transmission electron microscopy (HR-TEM. Particle size of the caffeine loaded PNTs is < 40 nm. The FT-Raman spectrum signals are enhanced in the region of 400–1700 cm−1. These data are ideal tool for the applications like biosensing and drug delivery research (DDS. Keywords: Caffeine, PNTs, Sensing, HR-TEM, FT-Raman data

STELLAR CORONAE, SOLAR FLARES: A DETAILED COMPARISON OF {sigma} GEM, HR 1099, AND THE SUN IN HIGH-RESOLUTION X-RAYS

Energy Technology Data Exchange (ETDEWEB)

Huenemoerder, David P. [Massachusetts Institute of Technology, Kavli Institute for Astrophysics and Space Research, 70 Vassar St., Cambridge, MA 02139 (United States); Phillips, Kenneth J. H. [Visiting Scientist, Space Research Center, Polish Academy of Sciences, 51-622, Kopernika 11, Wroclaw (Poland); Sylwester, Janusz; Sylwester, Barbara, E-mail: dph@space.mit.edu, E-mail: kennethjhphillips@yahoo.com, E-mail: js@cbk.pan.wroc.pl, E-mail: bs@cbk.pan.wroc.pl [Space Research Center, Polish Academy of Sciences, 51-622, Kopernika 11, Wroclaw (Poland)

2013-05-10

The Chandra High Energy Transmission Grating Spectrometer (HETG) spectra of the coronally active binary stars {sigma} Gem and HR 1099 are among the highest fluence observations for such systems taken at high spectral resolution in X-rays with this instrument. This allows us to compare their properties in detail to solar flare spectra obtained with the Russian CORONAS-F spacecraft's RESIK instrument at similar resolution in an overlapping bandpass. Here we emphasize the detailed comparisons of the 3.3-6.1 A region (including emission from highly ionized S, Si, Ar, and K) from solar flare spectra to the corresponding {sigma} Gem and HR 1099 spectra. We also model the larger wavelength range of the HETG, from 1.7 to 25 A - having emission lines from Fe, Ca, Ar, Si, Al, Mg, Ne, O, and N-to determine coronal temperatures and abundances. {sigma} Gem is a single-lined coronally active long-period binary which has a very hot corona. HR 1099 is a similar, but shorter period, double-lined system. With very deep HETG exposures we can even study emission from some of the weaker species, such as K, Na, and Al, which are important since they have the lowest first ionization potentials, a parameter well known to be correlated with elemental fractionation in the solar corona. The solar flare temperatures reach Almost-Equal-To 20 MK, comparable to the {sigma} Gem and HR 1099 coronae. During the Chandra exposures, {sigma} Gem was slowly decaying from a flare and its spectrum is well characterized by a collisional ionization equilibrium plasma with a broad temperature distribution ranging from 2 to 60 MK, peaking near 25 MK, but with substantial emission from 50 MK plasma. We have detected K XVIII and Na XI emission which allow us to set limits on their abundances. HR 1099 was also quite variable in X-rays, also in a flare state, but had no detectable K XVIII. These measurements provide new comparisons of solar and stellar coronal abundances, especially at the lowest first

Real-world effectiveness of everolimus-based therapy versus fulvestrant monotherapy in HR(+)/HER2(-) metastatic breast cancer.

Science.gov (United States)

Hao, Yanni; Lin, Peggy L; Xie, Jipan; Li, Nanxin; Koo, Valerie; Ohashi, Erika; Wu, Eric Q; Rogerio, Jaqueline

2015-08-01

Assessing real-world effectiveness of everolimus-based therapy (EVE) versus fulvestrant monotherapy (FUL) among postmenopausal women with hormone receptor-positive (HR(+))/HER2(-) metastatic breast cancer (mBC) after progression on nonsteroidal aromatase inhibitor (NSAI). Medical charts of community-based patients who received EVE or FUL for mBC after NSAI were examined. Progression-free survival (PFS), time on treatment and time to chemotherapy were compared using Kaplan-Meier curves and Cox proportional hazards models adjusting for line of therapy and patient characteristics. 192 patients received EVE and 156 FUL. After adjusting for patient characteristics, EVE was associated with significantly longer PFS than FUL (hazard ratio: 0.71; p = 0.045). EVE was associated with better PFS than FUL among NSAI-refractory postmenopausal HR(+)/HER2(-) mBC patients.

HR 1362 - A test case for stellar dynamo theories

International Nuclear Information System (INIS)

Strassmeier, K.G.; Hall, D.S.; Barksdale, W.S.; Jusick, A.T.; Henry, G.W.

1990-01-01

An analysis of 11 yr of photometry of HR 1362 = EK Eri has shown a well-established photometric period of 335 days. This confirms an earlier period determination of about 310 days from 3 yr of APT data and is consistent with a new v sin i determination of 2 + or - 2 km/s. Recent Ca II H and K observations show moderately strong H and K emission lines at a flux level of log F prime (K) of about 6.5 ergs sq m/s. If the photometric period is interpreted as the rotation period, this surface flux is more than one order of magnitude larger than what can be expected from empirical activity versus rotation relationships. The spectrum and the U-B and B-V colors are consistent with a single G8 III-IV spectral classification, while the V-R and V-I values indicate a small color excess, typical of chromospherically active stars. 27 refs

Evaluation of bone microstructure in CRPS-affected upper limbs by HR-pQCT.

Science.gov (United States)

Mussawy, Haider; Schmidt, Tobias; Rolvien, Tim; Rüther, Wolfgang; Amling, Michael

2017-01-01

Complex regional pain syndrome (CRPS) is a major complication after trauma, surgery, and/or immobilization of an extremity. The disease often starts with clinical signs of local inflammation and develops into a prolonged phase that is characterized by trophic changes and local osteoporosis and sometimes results in functional impairment of the affected limb. While the pathophysiology of CRPS remains poorly understood, increased local bone resorption plays an undisputed pivotal role. The aim of this retrospective clinical study was to assess the bone microstructure in patients with CRPS. Patients with CRPS type I of the upper limb whose affected and unaffected distal radii were analyzed by high-resolution peripheral quantitative computed tomography (HR-pQCT) were identified retrospectively. The osteology laboratory data and dual-energy X-ray absorptiometry (DXA) images of the left femoral neck and lumbar spine, which were obtained on the same day as HR-pQCT, were extracted from the medical records. Five patients were identified. The CRPS-affected upper limbs had significantly lower trabecular numbers and higher trabecular thicknesses than the unaffected upper limbs. However, the trabecular bone volume to total bone volume and cortical thickness values of the affected and unaffected sides were similar. Trabecular thickness tended to increase with time since disease diagnosis. CRPS associated with significant alterations in the bone microstructure of the affected upper limb that may amplify as the duration of disease increases.

HR professionals exploring cooperative configurational human resource management using a serious game: what do they miss?

NARCIS (Netherlands)

Collou, Luuk Dirk; Bruinsma, Guido Wybe Jan; van Riemsdijk, Maarten

2017-01-01

Configurational thinking in HRM is expected to increase understanding of the HRM-firm performance link and potentially aid HR professionals in the complex task of designing effective HRM. Here, we specify configurational theory in HRM to a level of detail that has been lacking. We present two

Aqueous U(VI) interaction with magnetite nanoparticles in a mixed flow reactor system: HR-XANES study

International Nuclear Information System (INIS)

Pidchenko, I; Heberling, F; Finck, N; Schild, D; Bohnert, E; Schäfer, T; Rothe, J; Geckeis, H; Vitova, T; Kvashnina, KO

2016-01-01

The redox variations and changes in local atomic environment of uranium (U) interacted with the magnetite nanoparticles were studied in a proof of principle experiment by the U L 3 and M 4 edges high energy resolution X-ray absorption near edge structure (HR-XANES) technique. We designed and applied a mixed flow reactor (MFR) set-up to maintain dynamic flow conditions during U-magnetite interactions. Formation of hydrolyzed, bi- and poly-nuclear U species were excluded by slow continuous injection of U(VI) (10 -6 M) and pH control integrated in the MFR set-up. The applied U HR-XANES technique is more sensitive to minor changes in the U redox states and bonding compared to the conventional XANES method. Major U(VI) contribution in uranyl type of bonding is found in the magnetite nanoparticles after three days operation time of the MFR. Indications for shortening of the U-O axial bond length for the magnetite compared to the maghemite system are present too. (paper)

DEBRIS DISTRIBUTION IN HD 95086—A YOUNG ANALOG OF HR 8799

International Nuclear Information System (INIS)

Su, Kate Y. L.; Smith, Paul S.; Rieke, George H.; Morrison, Sarah; Malhotra, Renu; Balog, Zoltan

2015-01-01

HD 95086 is a young early-type star that hosts (1) a 5 M J planet at the projected distance of 56 AU revealed by direct imaging, and (2) a prominent debris disk. Here we report the detection of 69 μm crystalline olivine feature from the disk using the Spitzer/MIPS-SED data covering 55-95 μm. Due to the low resolution of the MIPS-SED mode, this feature is not spectrally resolved, but is consistent with the emission from crystalline forsterite contributing ∼5% of the total dust mass. We also present detailed analysis of the disk spectral energy distribution and re-analysis of resolved images obtained by Herschel. Our results suggest that the debris structure around HD 95086 consists of a warm (∼175 K) belt, a cold (∼55 K) disk, and an extended disk halo (up to ∼800 AU), and is very similar to that of HR 8799. We compare the properties of the three debris components, and suggest that HD 95086 is a young analog of HR 8799. We further investigate and constrain single-planet, two-planet, three-planet, and four-planet architectures that can account for the observed debris structure and are compatible with dynamical stability constraints. We find that equal-mass four-planet configurations of geometrically spaced orbits, with each planet of mass ∼ 5 M J , could maintain the gap between the warm and cold debris belts, and also be just marginally stable for timescales comparable to the age of the system

DEBRIS DISTRIBUTION IN HD 95086—A YOUNG ANALOG OF HR 8799

Energy Technology Data Exchange (ETDEWEB)

Su, Kate Y. L.; Smith, Paul S.; Rieke, George H. [Steward Observatory, University of Arizona, 933 N Cherry Ave., Tucson, AZ 85721 (United States); Morrison, Sarah; Malhotra, Renu [Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721 (United States); Balog, Zoltan, E-mail: ksu@as.arizona.edu [Max-Planck-Institut für Astronomie, Königstuhl 17 D-69117, Heidelberg (Germany)

2015-02-01

HD 95086 is a young early-type star that hosts (1) a 5 M{sub J} planet at the projected distance of 56 AU revealed by direct imaging, and (2) a prominent debris disk. Here we report the detection of 69 μm crystalline olivine feature from the disk using the Spitzer/MIPS-SED data covering 55-95 μm. Due to the low resolution of the MIPS-SED mode, this feature is not spectrally resolved, but is consistent with the emission from crystalline forsterite contributing ∼5% of the total dust mass. We also present detailed analysis of the disk spectral energy distribution and re-analysis of resolved images obtained by Herschel. Our results suggest that the debris structure around HD 95086 consists of a warm (∼175 K) belt, a cold (∼55 K) disk, and an extended disk halo (up to ∼800 AU), and is very similar to that of HR 8799. We compare the properties of the three debris components, and suggest that HD 95086 is a young analog of HR 8799. We further investigate and constrain single-planet, two-planet, three-planet, and four-planet architectures that can account for the observed debris structure and are compatible with dynamical stability constraints. We find that equal-mass four-planet configurations of geometrically spaced orbits, with each planet of mass ∼ 5 M{sub J} , could maintain the gap between the warm and cold debris belts, and also be just marginally stable for timescales comparable to the age of the system.

Data validation report for the 100-HR-3 Operable Unit, fifth round groundwater samples

International Nuclear Information System (INIS)

Vukelich, S.E.

1994-01-01

The data from the chemical analysis of 68 samples from the 100-HR-3 Operable Unit Third Quarter 1993 Groundwater Sampling Investigation and their related quality assurance samples were reviewed and validated to verify that reported sample results were of sufficient quality to support decisions regarding remedial actions performed at the site. Sample analysis included inorganics and general chemical parameters. Fifty three samples were validated for radiochemical parameters

Light variations of massive stars (α Cygni variables). XI. The behaviour of the S Doradus type stars AG Carinae and HR Carinae near minimum light

International Nuclear Information System (INIS)

Genderen van, A.M.; Kampen van, E.; Larsen, I.; Wanders, I.; Weeren van, N.; The, P.S.; Heemskerk, M.; Kraakman, H.; Remijn, L.; Heynderickx, D.

1990-01-01

VBLUW photometry of the micro variations of AG Car (1987/1988) and HR Car (1981/1982 and 1987/1988) and of the macro variations of HR Car (1984/1987) is presented and discussed. The quasi-periods for the micro variations are antiP = 10 d - 13 d for AG Car and antiP ∼ 20 d for HR Car. Both objects, although at or close to minimum light, show small S Dor eruptions (Δ V J ∼ 0.3 m 3) corresponding to an increase in the mass loss rate of about 20%. The time scale of these eruptions, presumably 0.5-1 yr, is thus much longer than the quasi-periods of the intrinsic variations. Therefore, independency between both phenomena is suggested. The reddening and luminosity of HR Car is discussed, as well as its temperature. A tentative estimation of T eff , based on the fluctuation in the colour indices, amounts to ∼ 14000 K ± 2000 K

Palbociclib: A Review in HR-Positive, HER2-Negative, Advanced or Metastatic Breast Cancer.

Science.gov (United States)

Kim, Esther S; Scott, Lesley J

2017-06-01

Oral palbociclib (Ibrance®) is a first-in-class, highly selective inhibitor of cyclin-dependent kinases 4 and 6 (i.e. a CDK4/6 inhibitor). It is indicated for the treatment of women with HR-positive, HER2-negative advanced or metastatic breast cancer, in combination with an aromatase inhibitor as initial endocrine-based therapy, and in combination with fulvestrant (with or without a luteinizing hormone-releasing hormone agonist) in those previously treated with endocrine therapy. In clinical trials, palbociclib in combination with letrozole as initial endocrine-based therapy in postmenopausal women (PALOMA-1 and PALOMA-2), or in combination with fulvestrant in pre-, peri-, or postmenopausal women with disease progression after endocrine therapy (PALOMA-3), significantly prolonged progression-free survival (PFS) and improved clinical benefit response (CBR) rates. Neutropenia was the most commonly reported any-grade and grade ≥ 3 adverse event. It was infrequently associated with febrile neutropenia (<2%) and generally manageable with a palbociclib dose delay, interruption or reduction, without the routine use of growth factors, and without affecting efficacy. In conclusion, oral palbociclib combination therapy is a valuable emerging option for use in patients with HR-positive, HER2-negative advanced or metastatic breast cancer.

RCRA facility investigation/corrective measures study work plan for the 100-HR-3 operable unit, Hanford Site, Richland, Washington

International Nuclear Information System (INIS)

1992-09-01

Four areas of the Hanford Site (the 100, 200, 300, and 1100 Areas) have been included on the US Environmental Protection Agency's (EPA's) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). Under the Hanford Federal Facility Agreement and Consent Order, signed by the Washington State Department of Ecology (Ecology), EPA, and the US Department of Energy (DOE), more than 1000 inactive waste disposal and unplanned release sites on the Hanford Site have been grouped into a number of source and groundwater operable units. These operable units contain contamination in the form of hazardous waste, radioactive/hazardous mixed waste, and other CERCLA hazardous substances. Also included in the Tri-Party Agreement are 55 Resource Conservation and Recovery Act (RCRA) treatment, storage, or disposal (TSD) facilities that will be closed or permitted to operate in accordance with RCRA regulations, under the authority of Chapter 173-303 Washington Administrative Code (WAC). Some of the TSD facilities are included in the operable units. This work plan and the attached supporting project plans establish the operable unit setting and the objectives, procedures, tasks, and schedule for conducting the RCRA facility investigation/corrective measures study (RFI/CMS) for the 100-HR-3 operable unit. The 100-HR-3 operable unit underlies the D/DR and H Areas, the 600 Area between them, and the six source operable units these areas contain. The 100-HR-3 operable unit includes all contamination found in the aquifer soils and water within its boundary. Source operable units include facilities and unplanned release sites that are potential sources of contamination. Separate work plans have been initiated for the 100-DR-1 (DOE-RL 1992a) and 100-HR-1 (DOE-RL 1992b) source operable units

Effect of Truncating AUC at 12, 24 and 48 hr When Evaluating the Bioequivalence of Drugs with a Long Half-Life.

Science.gov (United States)

Moreno, Isabel; Ochoa, Dolores; Román, Manuel; Cabaleiro, Teresa; Abad-Santos, Francisco

2016-01-01

Bioequivalence studies of drugs with a long half-life require long periods of time for pharmacokinetic sampling. The latest update of the European guideline allows the area under the curve (AUC) truncated at 72 hr to be used as an alternative to AUC0-t as the primary parameter. The objective of this study was to evaluate the effect of truncating the AUC at 48, 24 and 12 hr on the acceptance of the bioequivalence criterion as compared with truncation at 72 hr in bioequivalence trials. The effect of truncated AUC on the within-individual coefficient of variation (CVw) and on the ratio of the formulations was also analysed. Twenty-eight drugs were selected from bioequivalence trials. Pharmacokinetic data were analysed using WinNonLin 2.0 based on the trapezoidal method. Analysis of variance (ANOVA) was performed to obtain the ratios and 90% confidence intervals for AUC at different time-points. The degree of agreement of AUC0-72 in relation to AUC0-48 and AUC0-24, according to the Landis and Koch classification, was 'almost perfect'. Statistically significant differences were observed when the CVw of AUC truncated at 72, 48 and 24 hr was compared with the CVw of AUC0-12. There were no statistically significant differences in the AUC ratio at any time-point. Compared to AUC0-72, Pearson's correlation coefficient for mean AUC, AUC ratio and AUC CVw was worse for AUC0-12 than AUC0-24 or AUC0-48. These preliminary results could suggest that AUC truncation at 24 or 48 hr is adequate to determine whether two formulations are bioequivalent. © 2015 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).

New spectro-photometric characterization of the substellar object HR 2562 B using SPHERE

Science.gov (United States)

Mesa, D.; Baudino, J.-L.; Charnay, B.; D'Orazi, V.; Desidera, S.; Boccaletti, A.; Gratton, R.; Bonnefoy, M.; Delorme, P.; Langlois, M.; Vigan, A.; Zurlo, A.; Maire, A.-L.; Janson, M.; Antichi, J.; Baruffolo, A.; Bruno, P.; Cascone, E.; Chauvin, G.; Claudi, R. U.; De Caprio, V.; Fantinel, D.; Farisato, G.; Feldt, M.; Giro, E.; Hagelberg, J.; Incorvaia, S.; Lagadec, E.; Lagrange, A.-M.; Lazzoni, C.; Lessio, L.; Salasnich, B.; Scuderi, S.; Sissa, E.; Turatto, M.

2018-05-01

Aims: HR 2562 is an F5V star located at 33 pc from the Sun hosting a substellar companion that was discovered using the Gemini planet imager (GPI) instrument. The main objective of the present paper is to provide an extensive characterization of the substellar companion, by deriving its fundamental properties. Methods: We observed HR 2562 with the near-infrared branch composed by the integral field spectrograph (IFS) and the infrared dual band spectrograph (IRDIS) of the spectro-polarimetric high-contrast exoplanet research (SPHERE) instrument at the very large telescope (VLT). During our observations IFS was operating in the Y J band, while IRDIS was observing with the H broadband filter. The data were reduced with the dedicated SPHERE GTO pipeline, which is custom designed for this instrument. On the reduced images, we then applied the post-processing procedures that are specifically prepared to subtract the speckle noise. Results: The companion is clearly detected in both IRDIS and IFS datasets. We obtained photometry in three different spectral bands. The comparison with template spectra allowed us to derive a spectral type of T2-T3 for the companion. Using both evolutionary and atmospheric models we inferred the main physical parameters of the companion obtaining a mass of 32 ± 14 MJup, Teff = 1100 ± 200 K, and log g = 4.75 ± 0.41. Based on observations made with European Southern Observatory (ESO) telescopes at Paranal Observatory in Chile, under program ID 198.C-0209(D).

Mitigation action plan for the 100-HR-3 and 100-KR-4 pump and treat project

International Nuclear Information System (INIS)

1996-11-01

This project involves drilling 22 wells, improving access roads to existing and new wells, laying connecting pipes, and constructing groundwater treatment facilities in the 100-KR-4 Area and 100-HR-3 Operable Units. Drilling is expected to be completed by September 1996, but the treatment operations will continue for approximately 10 years

What factors influence training opportunities for older workers? Three factorial surveys exploring the attitudes of HR professionals

NARCIS (Netherlands)

Lazazzara, A.; Karpinska, K.; Henkens, C.J.I.M.

2011-01-01

The core research questions addressed in this paper are: what factors influence HR professionals in deciding whether to approve training proposals for older workers? What kind of training are they more likely to recommend for older employees and in which organizational contexts? We administered

Exploring the associations of culture with careers and the mediating role of HR practices: A conceptual model

NARCIS (Netherlands)

Kats, M.S.; van Emmerik, I.J.H.; Blenkinsopp, J.; Khapova, S.N.

2010-01-01

Purpose: The conceptual framework developed in the present study aims to highlight the importance of human resource (HR) practices as a mediator between national culture and employees' careers. Design/methodology/approach: The approach taken is a literature review and the development of a conceptual

Family responsibilities discrimination, HR work-family discourse and organizational mediation of US civil rights law

OpenAIRE

Robin, Stryker; Heidi, Reynolds-Stenson; Krista, Frederico

2017-01-01

Because the US addresses work-family concerns mostly through voluntary employer-provided benefits combined with anti-discrimination legislation, organizational mediation of law shapes the content and impact of employ-ers’ response to employees’ work- family issues. Centrality of organiza-tional mediation means centrality of HR professional discourse. Given skyrocketing lawsuits claiming family responsibilities discrimination (FRD), we examine FRD-related discourse, 1980-2012, in the two high...

The HR diagram for luminous stars in nearby galaxies

International Nuclear Information System (INIS)

Humphreys, R.M.

1978-01-01

Due to the extreme faintness of stars in other galaxies it is only possible to sample the brightest stars in the nearest galaxies. The observations must then be compared with comparable data for the brightest stars, the supergiants and O-type stars, in the Milky Way. The data for the luminous stars are most complete for the Milky Way and the Large Magellanic Cloud. The luminosities for the stars in our Galaxy are based on their membership in associations and clusters, and consequently are representative of Population I within approximately 3kpc of the Sun. The data for the stars in the LMC with spectral types O to G8 come from published observations, and the M supergiants are from the author's recent observations of red stars in the LMC. This is the first time that the M supergiants have been included in an HR diagram of the Large Cloud. The presence of the red stars is important for any discussion of the evolution of the massive stars. (Auth.)

1H HR-MAS NMR Spectroscopy and the Metabolite Determination of Typical Foods in Mediterranean Diet

Directory of Open Access Journals (Sweden)

Carmelo Corsaro

2015-01-01

Full Text Available NMR spectroscopy has become an experimental technique widely used in food science. The experimental procedures that allow precise and quantitative analysis on different foods are relatively simple. For a better sensitivity and resolution, NMR spectroscopy is usually applied to liquid sample by means of extraction procedures that can be addressed to the observation of particular compounds. For the study of semisolid systems such as intact tissues, High-Resolution Magic Angle Spinning (HR-MAS has received great attention within the biomedical area and beyond. Metabolic profiling and metabolism changes can be investigated both in animal organs and in foods. In this work we present a proton HR-MAS NMR study on the typical vegetable foods of Mediterranean diet such as the Protected Geographical Indication (PGI cherry tomato of Pachino, the PGI Interdonato lemon of Messina, several Protected Designation of Origin (PDO extra virgin olive oils from Sicily, and the Traditional Italian Food Product (PAT red garlic of Nubia. We were able to identify and quantify the main metabolites within the studied systems that can be used for their characterization and authentication.

Measurement of 24-hr whole-body retention of Tc-99mMDP with a thyroid uptake probe: quantitative assessment of metabolic and metastatic bone diseases

International Nuclear Information System (INIS)

Seto, H.; Futatsuya, R.; Kamei, T.; Furumoto, N.; Ishizaki, Y.; Hada, M.; Kakishita, M.

1983-01-01

A new method for measurement of 24-hr whole body retention (WBR) of Tc-99mMDP, using a thyroid uptake probe was established and its clinical significance was evaluated in 102 patients with various bone disorders, including metabolic and metastatic bone diseases, aged above 20 years old. Reproducibility of 24-hr WBR in 10 patients was very good (r=0.996). The 24-hr WBR of Tc-99mMDP in the normal subjects was 30.4 +- 4.6%. The WBR values of chronic renal failure, metastatic bone disease and hyperthyroidism groups were 98.4 +- 3.0, 44.0 +- 8.0, 40,6 +- 6.3% respectively, which were significantly higher (p < 0.001). However the WBR of steroid-induced osteoporotic group was significantly lower (17.3 +- 5.4%) as compared with the normal group (p < 0.001). Based on these results the method is simple, reproducible and accurate to measure 24-hr WBR of Tc-99mMDP. Quantification of WBR is of great clinical value to diagnose metabolic bone disease and to follow-up metabolic and metastatic bone disease after treatment

The role of human resource management in open innovation: exploring the relation between HR practices and OI

OpenAIRE

Paul, Svenja

2013-01-01

How do human resource practices strengthen open innovation activities? This inductive study of six cases led to propositions exploring that question. I thereby investigated the role of human resource management in open innovation, specifically the relation between HR practices and an employee's willingness to embrace open innovation.

Mexican Cervical Cancer Screening Study II: 6-month and 2-year follow-up of HR-HPV women treated with cryotherapy in a low-resource setting.

Science.gov (United States)

Starks, David; Arriba, Lucybeth Nieves; Enerson, Christine L; Brainard, Jennifer; Nagore, Norma; Chiesa-Vottero, Andres; Uribe, Jesús Villagran; Belinson, Jerome

2014-10-01

To determine the efficacy and tolerance of cryotherapy in a visual inspection with acetic acid (VIA) triage protocol after primary human papillomavirus (HPV) screening in a low-resource setting. This continuous series conducted over 2 years enrolled nonpregnant, high-risk HPV (HR-HPV)-positive women between the ages of 30 and 50 years, who resided in the state of Michoacán, Mexico, and had a history of no Pap smear screening or knowledge of Pap smear results within the last 3 years. These women were initially enrolled in the Mexican Cervical Cancer Screening Study II (MECCS II) trial and were treated with cryotherapy after VIA triage. They subsequently followed up at 6 months and 2 years for repeat VIA, colposcopy, and biopsy. A total of 291 women were treated with cryotherapy, of whom 226 (78%) followed up at 6 months. Of these 226 women, 153 (68%) were HR-HPV-negative; there were no findings of cervical intraepithelial neoplasia grade 2 (CIN2) or worse. The remaining 73 women (32%) were HR-HPV-positive; of these women, 2 had CIN2 and 3 had CIN3. Only 137 women followed up at 2 years. Of these 137 women, 116 were HR-HPV-negative and 21 were HR-HPV-positive. Of the 21 women positive for HR-HPV, 9 had negative biopsy results, 11 had CIN1, and 1 had no biopsy. The clearance rate of HR-HPV was 83% (95% confidence interval: 0.78-0.87). There were no biopsy findings of CIN2 or worse at 2 years. Before cryotherapy, of the 226 women, 15 (6.6%) were positive for endocervical curettage (ECC) and 5 (2.2%) were referred for surgical management. Of these 15 ECC-positive women, 10 (67%) followed up at 6 months and it was shown that no patient was ECC positive at that time point. Moreover, of the 15 ECC-positive women, 11 (73%) followed up at 2 years and it was shown that no patient was ECC positive at that time point. In our study, VIA had a false-positive rate of 5%. Cryotherapy was an effective, acceptable, and well-tolerated means of treating cervical dysplasia in a low

Pilot-scale treatability test plan for the 100-HR-3 operable unit

International Nuclear Information System (INIS)

1994-08-01

This document presents the treatability test plan for pilot-scale pump-and-treat testing at the 100-HR-3 Operable Unit. The test will be conducted in fulfillment of interim Milestone M-15-06E to begin pilot-scale pump-and-treat operations by August 1994. The scope of the test was determined based on the results of lab/bench-scale tests (WHC 1993a) conducted in fulfillment of Milestone M-15-06B. These milestones were established per agreement between the U.S. Department of Energy (DOE), the Washington State Department of Ecology and the U.S. Environmental Protection Agency (EPA), and documented on Hanford Federal of Ecology Facility Agreement and Consent Order Change Control Form M-15-93-02. This test plan discusses a pilot-scale pump-and-treat test for the chromium plume associated with the D Reactor portion of the 100-HR-3 Operable Unit. Data will be collected during the pilot test to assess the effectiveness, operating parameters, and resource needs of the ion exchange (IX) pump-and-treat system. The test will provide information to assess the ability to remove contaminants by extracting groundwater from wells and treating extracted groundwater using IX. Bench-scale tests were conducted previously in which chromium VI was identified as the primary contaminant of concern in the 100-D reactor plume. The DOWEX 21K trademark resin was recommended for pilot-scale testing of an IX pump-and-treat system. The bench-scale test demonstrated that the system could remove chromium VI from groundwater to concentrations less than 50 ppb. The test also identified process parameters to monitor during pilot-scale testing. Water will be re-injected into the plume using wells outside the zone of influence and upgradient of the extraction well

Aquifer test plan for the 100-HR-3 Operable Unit

International Nuclear Information System (INIS)

Swanson, L.C.; Hartman, M.J.

1994-01-01

This test plan directs hydrologic testing activities planned at three existing Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA) wells in the 100-HR-3 Operable Unit of the Hanford Site. Three additional wells will be installed near these existing wells and used as additional testing arid observation points during the field activities. Figure 1 shows the locations of the three test sites. A primary objective of the testing program is to provide more detailed hydraulic characterization information for the unconfined aquifer and targeted test sites than provided by the initial reconnaissance-level slug testing of Vukelich. A second objective is to evaluate the applicability of slug interference and dipole flow tests for detailed hydraulic characterization in an unconfined aquifer. This aquifer testing program will also be useful for substantiating hydraulic conductivities reported from previous slug tests and evaluating the effects of filter pack volume/configuration on slug test data. Vukelich recommended additional testing to address the latter two issues

Physician experiences and preferences in the treatment of HR+/HER2− metastatic breast cancer in the United States: a physician survey

International Nuclear Information System (INIS)

Lin, Peggy L.; Hao, Yanni; Xie, Jipan; Li, Nanxin; Zhong, Yichen; Zhou, Zhou; Signorovitch, James E.; Wu, Eric Q.

2015-01-01

Sequential endocrine therapy (ET) is recommended for postmenopausal women with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) metastatic breast cancer (mBC) and without visceral symptoms. Chemotherapy (CT) can be considered after sequential ETs, but is associated with adverse side effects. We assessed physicians' preferences and self-reported prescribing patterns for ET and CT in the treatment of HR+/HER2− mBC at community practices in the United States. Community-based oncologists/hematologists from a nationwide online panel who treated postmenopausal women with HR+/HER2− mBC were invited to complete a survey, blinded to the identity of study sponsor. Treatment preferences were collected by treatment class of ET-based regimens versus CT and by agent for postmenopausal HR+/HER2− mBC patients after prior nonsteroidal aromatase inhibitor use in the adjuvant or mBC setting. Among 213 physicians who completed the survey, 78% were male, 71% were based in small/intermediate practices (2–9 oncologists/subspecialists), 55% had >10 years of experience, and 58% referred to the National Comprehensive Cancer Network Guidelines when treating mBC. Among first-line ETs, anastrozole was the most frequently used treatment (35%), followed by everolimus-based (EVE, 34%) and fulvestrant-based (FUL, 15%) therapy. After first-line ET, the most preferred second- and third-line treatments were ET monotherapy (48% and 39%), ET combination therapy (31% and 19%), and CT monotherapy (13% and 30%). Comparing EVE versus FUL, physicians preferred EVE in all lines but first line. Efficacy was the most important consideration for treatment choice. Physicians prescribed CT in early lines mainly because of visceral symptoms. This survey of treatment patterns for HR+/HER2− mBC in community practice suggested that after first-line ET, ET mono- or combination therapy was commonly used for the second- and third-line treatments and CT

GEMINI PLANET IMAGER SPECTROSCOPY OF THE HR 8799 PLANETS c AND d

International Nuclear Information System (INIS)

Ingraham, Patrick; Macintosh, Bruce; Marley, Mark S.; Saumon, Didier; Marois, Christian; Dunn, Jennifer; Erikson, Darren; Barman, Travis; Bauman, Brian; Burrows, Adam; Chilcote, Jeffrey K.; Fitzgerald, Michael P.; De Rosa, Robert J.; Dillon, Daren; Gavel, Donald; Doyon, René; Goodsell, Stephen J.; Hartung, Markus; Hibon, Pascale; Graham, James R.

2014-01-01

During the first-light run of the Gemini Planet Imager we obtained K-band spectra of exoplanets HR 8799 c and d. Analysis of the spectra indicates that planet d may be warmer than planet c. Comparisons to recent patchy cloud models and previously obtained observations over multiple wavelengths confirm that thick clouds combined with horizontal variation in the cloud cover generally reproduce the planets' spectral energy distributions. When combined with the 3 to 4 μm photometric data points, the observations provide strong constraints on the atmospheric methane content for both planets. The data also provide further evidence that future modeling efforts must include cloud opacity, possibly including cloud holes, disequilibrium chemistry, and super-solar metallicity

Cytokine genes polymorphisms of TNF, IFN-y and IL-12 as potential predictors in the onset of cervical disease associated with HR HPV infections

Directory of Open Access Journals (Sweden)

Tasić Dijana

2015-01-01

Full Text Available Cervical cancer highly correlates with infection caused by highly oncogenic types of human papillomavirus (high risk HPV, HR HPV, which is one of the most common sexually transmitted pathogens and is a key factor in the development of cervical disease. However, malignant transformation of cells and tumor development are multifactorial and result from the interaction of a large number of factors such as virus genotype and its oncogenic potential, the state of the infected cells, the immune response of the host, as well as many cofactors such as smoking, oral contraceptives, multiparity, early beginning of sexual life, promiscuity, poor socio-economic conditions, poor diet, etc. Recently, an increasing number of studies have focused on examining the role of genetic basis of the pathogenesis and evolution of HR HPV cervical disease. It is known that genes polymorphisms that encode proteins involved in the functioning of Th1 and Th17 cell response may be associated with better or worse prognosis of cervical disease in women with persistent HR HPV infection. Therefore, the single nucleotide polymorphisms (SNP of the genes encoding TNF, IFN-y and IL-12 can be considered as putative biomarkers that may have predictive value for the development of the HR HPV cervical carcinoma.

Resolving the planetesimal belt of HR 8799 with ALMA

Science.gov (United States)

Booth, Mark; Jordán, Andrés; Casassus, Simon; Hales, Antonio S.; Dent, William R. F.; Faramaz, Virginie; Matrà, Luca; Barkats, Denis; Brahm, Rafael; Cuadra, Jorge

2016-07-01

The star HR 8799 hosts one of the largest known debris discs and at least four giant planets. Previous observations have found evidence for a warm belt within the orbits of the planets, a cold planetesimal belt beyond their orbits and a halo of small grains. With the infrared data, it is hard to distinguish the planetesimal belt emission from that of the grains in the halo. With this in mind, the system has been observed with ALMA in band 6 (1.34 mm) using a compact array format. These observations allow the inner edge of the planetesimal belt to be resolved for the first time. A radial distribution of dust grains is fitted to the data using an MCMC method. The disc is best fitted by a broad ring between 145^{+12}_{-12} au and 429^{+37}_{-32} au at an inclination of 40^{+5}_{-6}° and a position angle of 51^{+8}_{-8}°. A disc edge at ˜145 au is too far out to be explained simply by interactions with planet b, requiring either a more complicated dynamical history or an extra planet beyond the orbit of planet b.

Is progression-free survival a more relevant endpoint than overall survival in first-line HR+/HER2− metastatic breast cancer?

Directory of Open Access Journals (Sweden)

Forsythe A

2018-05-01

Full Text Available Anna Forsythe,1 David Chandiwana,2 Janina Barth,3 Marroon Thabane,4 Johan Baeck,5 Anastasiya Shor,1 Gabriel Tremblay6 1Health Technology Assessment Evidence, Purple Squirrel Economics, New York, NY, USA; 2Global Value and Access, Novartis Pharmaceutical Corporation, East Hanover, NJ, USA; 3German Market Access, Novartis Pharma GmbH, Nuremberg, Germany; 4Health Policy and Patient Access, Novartis Pharmaceuticals Incorporated, Dorval, QC, Canada; 5Global Medical Affairs (Oncology Business Unit, Novartis Pharmaceutical Corporation, East Hanover, NJ, USA; 6Health Economics, Purple Squirrel Economics, New York, NY, USA Background: Hormone receptor-positive (HR+, human epidermal growth factor receptor 2- negative (HER2−, metastatic breast cancer (MBC accounts for 73% of all MBCs. Endocrine therapy (ET is the basis of first-line (1L therapy for patients with HR+/HER2− MBC. Novel therapies have demonstrated improvements in progression-free survival (PFS compared to ET. The clinical relevance of PFS is being debated, as there is no proven direct correlation with overall survival (OS benefit to date. We reviewed studies of HR+/HER2− MBC to assess PFS and other factors that influence OS and treatment response, and health-related quality of life (HRQoL. Methods: The Embase®, Medline®, and Cochrane databases were systematically searched to identify studies in adult women with HR+/HER2− MBC, published between January 2006 and January 2017, and written in English. Phase II and III randomized controlled trials (RCTs, observational, and retrospective studies were included. Results: Seventy-nine RCTs were identified: 58 (73% in the 1L+ setting and 21 (27% in second-line or greater settings. PFS hazard ratios (HRs were reported in 61 (77% studies; 31 (39% reported significant PFS improvements. OS was reported in 44 (41% studies; 12 (15% reported significant OS improvements. Significant improvements in both PFS and OS were reported in only 6 (8% studies

The role of organizational context in fostering employee proactive behavior: : Interplay between HR system configurations and relational climates

NARCIS (Netherlands)

Batistic, S.; Cerne, Matej; Kaše, R.; Zupic, Ivan

2016-01-01

Emphasizing the role of the organizational context and adopting a multilevel approach, we propose that the interplay between HR system configurations and relational climates has a cross-level effect on employee proactive behavior. Using a sample of 211 employees in 25 companies, we show that the

HR policies and practices in vocational education and training institutions. Understanding the implementation gap through the lens of discourses

NARCIS (Netherlands)

Runhaar, P.R.; Runhaar, H.A.C.

2012-01-01

Vocational education and training (VET) institutions face serious challenges, like educational innovations and upcoming teacher shortages, which require them to invest in their human capital. However, the implementation of human resources (HR) policies and practices often stagnates. Using the

DID FOMALHAUT, HR 8799, AND HL TAURI FORM PLANETS VIA THE GRAVITATIONAL INSTABILITY? PLACING LIMITS ON THE REQUIRED DISK MASSES

International Nuclear Information System (INIS)

Nero, D.; Bjorkman, J. E.

2009-01-01

Disk fragmentation resulting from the gravitational instability has been proposed as an efficient mechanism for forming giant planets. We use the planet Fomalhaut b, the triple-planetary system HR 8799, and the potential protoplanet associated with HL Tau to test the viability of this mechanism. We choose the above systems since they harbor planets with masses and orbital characteristics favored by the fragmentation mechanism. We do not claim that these planets must have formed as the result of fragmentation, rather the reverse: if planets can form from disk fragmentation, then these systems are consistent with what we should expect to see. We use the orbital characteristics of these recently discovered planets, along with a new technique to more accurately determine the disk cooling times, to place both lower and upper limits on the disk surface density-and thus mass-required to form these objects by disk fragmentation. Our cooling times are over an order of magnitude shorter than those of Rafikov, which makes disk fragmentation more feasible for these objects. We find that the required mass interior to the planet's orbital radius is ∼0.1 M sun for Fomalhaut b, the protoplanet orbiting HL Tau, and the outermost planet of HR 8799. The two inner planets of HR 8799 probably could not have formed in situ by disk fragmentation.

HR policies and practices in vocational education and training institutions: understanding the implementation gap through the lens of discourses

NARCIS (Netherlands)

Runhaar, P.R.; Runhaar, H.

2012-01-01

Vocational education and training (VET) institutions face serious challenges, like educational innovations and upcoming teacher shortages, which require them to invest in their human capital. However, the implementation of human resources (HR) policies and practices often stagnates. Using the Dutch

The rise (and fall?) of HR analytics : A study into the future application, value, structure, and system support

NARCIS (Netherlands)

Sjoerd van den Heuvel; Tanya Bondarouk

2017-01-01

Purpose – Driven by the rapidly accelerating pace of technology-enabled developments within human resource management (HRM), human resource (HR) analytics is infiltrating the research and business agenda. As one of the first in its field, the purpose of this paper is to explore what the future of

Metabolism of the synthetic cannabinoids AMB-CHMICA and 5C-AKB48 in pooled human hepatocytes and rat hepatocytes analyzed by UHPLC-(IMS)-HR-MSE

DEFF Research Database (Denmark)

Mardal, Marie; Dalsgaard, Petur Weihe; Qi, Bing

2018-01-01

metabolites of the synthetic cannabinoids, AMB-CHMICA and 5C-AKB48, using an in silico-assisted workflow with analytical data acquired using ultra-high-performance liquid chromatography–(ion mobility spectroscopy)–high resolution–mass spectrometry in data-independent acquisition mode (UHPLC......-(IMS)-HR-MSE). The metabolites were identified after incubation with rat and pooled human hepatocytes using UHPLC-HR-MSE, followed by UHPLC-IMS-HR-MSE. Metabolites of AMB-CHMICA and 5C-AKB48 were predicted with Meteor (Lhasa Ltd) and imported to the UNIFI software (Waters). The predicted metabolites were assigned to analytical...... components supported by the UNIFI in silico fragmentation tool. The main metabolic pathway of AMB-CHMICA was O-demethylation and hydroxylation of the methylhexyl moiety. For 5C-AKB48, the main metabolic pathways were hydroxylation(s) of the adamantyl moiety and oxidative dechlorination with subsequent...

Evidence for the control of phytolith formation in Cucurbita fruits by the hard rind (Hr) genetic locus: Archaeological and ecological implications

Science.gov (United States)

Piperno, Dolores R.; Holst, Irene; Wessel-Beaver, Linda; Andres, Thomas C.

2002-01-01

Many angiosperms, both monocotyledons and dicotyledons, heavily impregnate their vegetative and reproductive organs with solid particles of silicon dioxide (SiO2) known as opaline phytoliths. The underlying mechanisms accounting for the formation of phytoliths in plants are poorly understood, however. Using wild and domesticated species in the genus Cucurbita along with their F1 and F2 progeny, we have demonstrated that the production of large diagnostic phytoliths in fruit rinds exhibits a one-to-one correspondence to the lignification of these structures. We propose that phytolith formation in Cucurbita fruits is primarily determined by a dominant genetic locus, called hard rind (Hr), previously shown to code for lignin deposition. If true, this evidence represents a demonstration of genetic control over phytolith production in a dicotyledon and provides considerable support to hypotheses that silica phytoliths constitute another important system of mechanical defense in plants. Our research also identifies Hr as another single locus controlling more than one important phenotypic difference between wild and domesticated plants, and establishes rind tissue cell structure and hardness under the effects of Hr as an important determinant of phytolith morphology. When recovered from pre-Columbian archaeological sites, Cucurbita phytoliths represent genetically controlled fossil markers of exploitation and domestication in this important economic genus. PMID:12149443

Complete genome sequence of Desulfohalobium retbaense type strain (HR100T)

Energy Technology Data Exchange (ETDEWEB)

Spring, Stefan [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Nolan, Matt [U.S. Department of Energy, Joint Genome Institute; Lapidus, Alla L. [U.S. Department of Energy, Joint Genome Institute; Glavina Del Rio, Tijana [U.S. Department of Energy, Joint Genome Institute; Copeland, A [U.S. Department of Energy, Joint Genome Institute; Tice, Hope [U.S. Department of Energy, Joint Genome Institute; Cheng, Jan-Fang [U.S. Department of Energy, Joint Genome Institute; Lucas, Susan [U.S. Department of Energy, Joint Genome Institute; Land, Miriam L [ORNL; Chen, Feng [U.S. Department of Energy, Joint Genome Institute; Bruce, David [Los Alamos National Laboratory (LANL); Goodwin, Lynne A. [Los Alamos National Laboratory (LANL); Pitluck, Sam [U.S. Department of Energy, Joint Genome Institute; Ivanova, N [U.S. Department of Energy, Joint Genome Institute; Mavromatis, K [U.S. Department of Energy, Joint Genome Institute; Mikhailova, Natalia [U.S. Department of Energy, Joint Genome Institute; Pati, Amrita [U.S. Department of Energy, Joint Genome Institute; Chen, Amy [U.S. Department of Energy, Joint Genome Institute; Palaniappan, Krishna [U.S. Department of Energy, Joint Genome Institute; Hauser, Loren John [ORNL; Chang, Yun-Juan [ORNL; Jeffries, Cynthia [Oak Ridge National Laboratory (ORNL); Munk, Christine [U.S. Department of Energy, Joint Genome Institute; Kiss, Hajnalka [Los Alamos National Laboratory (LANL); Chain, Patrick S. G. [Lawrence Livermore National Laboratory (LLNL); Han, Cliff [Los Alamos National Laboratory (LANL); Brettin, Thomas S [ORNL; Detter, J. Chris [U.S. Department of Energy, Joint Genome Institute; Schuler, Esther [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Goker, Markus [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Rohde, Manfred [HZI - Helmholtz Centre for Infection Research, Braunschweig, Germany; Bristow, James [U.S. Department of Energy, Joint Genome Institute; Eisen, Jonathan [U.S. Department of Energy, Joint Genome Institute; Markowitz, Victor [U.S. Department of Energy, Joint Genome Institute; Hugenholtz, Philip [U.S. Department of Energy, Joint Genome Institute; Kyrpides, Nikos C [U.S. Department of Energy, Joint Genome Institute; Klenk, Hans-Peter [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany

2010-01-01

Desulfohalobium retbaense (Ollivier et al. 1991) is the type species of the polyphyletic genus Desulfohalobium, which comprises, at the time of writing, two species and represents the family Desulfohalobiaceae within the Deltaproteobacteria. D. retbaense is a moderately halophilic sulfate-reducing bacterium, which can utilize H2 and a limited range of organic substrates, which are incompletely oxidized to acetate and CO2, for growth. The type strain HR100T was isolated from sediments of the hypersaline Retba Lake in Senegal. Here we describe the features of this organism, together with the complete genome sequence and annotation. This is the first completed genome sequence of a member of the family Desulfohalobiaceae. The 2,909,567 bp genome (one chromosome and a 45,263 bp plasmid) with its 2,552 protein-coding and 57 RNA genes is a part of the Genomic Encyclopedia of Bacteria and Archaea project.

Analysis of HR consultants and French recruiters activity on LinkedIn. In between work resource and quest of identity development

Directory of Open Access Journals (Sweden)

Hélène HOBLINGRE

2016-12-01

Full Text Available This article investigates usage of LinkedIn by HR professionals. Based on twelve HR consultants and recruiters interviews, LinkedIn usage analysis highlights that this tool is used in a mix of private and professional practices. It sheds a light on the tension of using LinkedIn as a business tool versus LinkedIn as a tool to develop personal projects. Using LinkedIn in a professional context implies following norms and guidelines that impact user freedom. As a consequence, this prevents user from benefiting from all LinkedIn developmental capabilities. Eventually, our results stress the need for an individual to use LinkedIn as a reflective practitioner. This should be done in the light of building purpose to professional activities and accommodating functional usage with strategic practices.

PLEIADES-HR INNOVATIVE TECHNIQUES FOR GEOMETRIC IMAGE QUALITY COMMISSIONING

Directory of Open Access Journals (Sweden)

D. Greslou

2012-07-01

Full Text Available Since the beginning of 2012, the first Pleiades-HR satellite of the program conducted by the French National Space Agency, CNES, delivers 20 km wide color scenes with a 70 cm ground sampling distance. A second satellite should be launched in 2013 which will achieve an almost world-wide coverage with a revisit interval of 24h. The assessment of the image quality and the calibration operation have been performed by CNES Image Quality team during the 6 month commissioning phase that followed the satellite launch. The geometric commissioning activities consist in improve the geometric quality of the images in order to meet very demanding specifications as localization accuracy, local coherence, dynamic stability, length alteration … This goal has been achieved through the implementation of new methods of calibration and performance assessment. Some of these methods are based on the exploitation of very specific satellite acquisitions that have been achieved thanks to the amazing agility of the Pleiades satellite. Thus, many stars acquisitions and very slow earth pictures have been processed to characterize dynamic phenomena. Similarly, “along-cross track” pairs have been exploited to improve the accuracy of the focal plane description. This paper deals with these new methods. It describes their accuracy and their operational interests.

Percepția angajaților asupra practicilor de HR, potrivirea persoană-organizație și satisfacția în muncă

OpenAIRE

Mirela Botezatu-Rosianu

2013-01-01

This paper is based on the general assumption that human resource management practices can play animportant role in matching people with the organisations and the jobs they work in. Also, high-performance HRMpractices can have an influence upon employees’ outputs. The aim of this study is to investigate, on one hand, therelations between employees’ perceptions of HR practices and P-O fit, and on the other hand, between employees’perceptions of HR practices with work engagement and job satisfa...

Percepția angajaților asupra practicilor de HR, potrivirea persoană-organizație și satisfacția în muncă

Directory of Open Access Journals (Sweden)

Mirela Botezatu-Rosianu

2013-10-01

Full Text Available This paper is based on the general assumption that human resource management practices can play animportant role in matching people with the organisations and the jobs they work in. Also, high-performance HRMpractices can have an influence upon employees’ outputs. The aim of this study is to investigate, on one hand, therelations between employees’ perceptions of HR practices and P-O fit, and on the other hand, between employees’perceptions of HR practices with work engagement and job satisfaction. For collecting the data were usedquestionnaires. Results from a sample of 52 employees (67,3% women support correlations between perceived HRpractices and P-O fit, work engagement and job satisfaction. In plus, results support a mediating role of P-O fit inthe relationship between perceived HR practices and job satisfaction. The results of this study emphasizes theimportance of HRM practices in work engagement, job satisfaction and P-O fit.

A trial to reduce cardiac motion artifact on HR-CT images of the lung with the use of subsecond scan and special cine reconstruction algorithm

Energy Technology Data Exchange (ETDEWEB)

Sakai, Fumikazu; Tsuuchi, Yasuhiko; Suzuki, Keiko; Ueno, Keiko; Yamada, Takayuki; Okawa, Tomohiko [Tokyo Women`s Medical Coll. (Japan); Yun, Shen; Horiuchi, Tetsuya; Kimura, Fumiko

1998-05-01

We describe our trial to reduce cardiac motion artifacts on HR-CT images caused by cardiac pulsation by combining use of subsecond CT (scan time 0.8 s) and a special cine reconstruction algorithm (cine reconstruction algorithm with 180-degree helical interpolation). Eleven to 51 HR-CT images were reconstructed with the special cine reconstruction algorithm at the pitch of 0.1 (0.08 s) from the data obtained by two to six contigious rotation scans at the same level. Images with the fewest cardiac motion artifacts were selected for evaluation. These images were compared with those reconstructed with a conventional cine reconstruction algorithm and step-by-step scan. In spite of its increased radiation exposure, technical complexity and slight degradation of spatial resolution, our method was useful in reducing cardiac motion artifacts on HR-CT images in regions adjacent to the heart. (author)

Annual Summary Report, February to December 1998, for the 100-HR-3 and 100-KR-4 Pump-and-Treat Operations and Operable Units

International Nuclear Information System (INIS)

Boutin, R. J.

1999-01-01

This annual summary report discusses the interim remedial actions at the 100-HR-3 and 100-KR-4 Operable Units (OUs) for February 1,1998, through December 31, 1998. This is the second annual summary report that has been submitted for these OUs; the first report was released in April 1998 (DOE-RL 1998). Ongoing annual summaries and performance evaluations of each of the pump-and-treat systems are required by the Remedial Design Report and Remedial Action Work Plan for the 100-HR-3 and 100-KR-4 Groundwater Operable Units' Interim Action (RDR/RAWP) (DOE-RL 1996)

Spectrophotometry of peculiar B and A stars. XVIII - The helium rich variable stars HR 1890, Sigma Orionis E, and HD 37776

Science.gov (United States)

Adelman, S. J.; Pyper, D. M.

1985-01-01

Optical region spectrophotometry at 3300-7850 A has been obtained for three helium rich stars, HR 1890, Sigma Ori E, and HD 37776, of the Orion OB1 Association. New uvby-beta photometry of HR 1890 and HD 37776 as well as published data are also used to investigate the variability of these stars. A new period of 1.53862 days was determined for HD 37776. For all three stars H-beta varies in antiphase with strong He I lines. The spectrophotometric bandpass containing the strong He I line at 4471 A varies in phase with the R index of Pedersen and Thomsen (1977). Evidence is found for weak absorption features which appear to be an extension of the 5200 A feature seen in cooler CP stars.

Preparation of dielectrics HR mirrors from colloidal oxide suspensions containing organic polymer binders

International Nuclear Information System (INIS)

Thomas, I.M.

1994-01-01

Colloidal suspensions of oxides have been used to prepare dielectric HR (high reflective) mirrors, specifically for high power fusion case applications, on substrates up to 38 cm square using a meniscus coater. These coatings consist of porous quarterwave layers of alternating high and low refractive index oxides. Silica was used as the low index oxide and AlOOH, ZrO 2 , or HfO 2 as the high index material. Coatings were weak because of low particle-to-particle adhesion. Use of organic polymer binders in the high index component was found to increase strength, thereby improving the laser damage threshold and also reducing the number of layers required for 99% reflection due to increased refractive index

Everolimus plus exemestane in postmenopausal patients with HR(+) breast cancer: BOLERO-2 final progression-free survival analysis.

Science.gov (United States)

Yardley, Denise A; Noguchi, Shinzaburo; Pritchard, Kathleen I; Burris, Howard A; Baselga, José; Gnant, Michael; Hortobagyi, Gabriel N; Campone, Mario; Pistilli, Barbara; Piccart, Martine; Melichar, Bohuslav; Petrakova, Katarina; Arena, Francis P; Erdkamp, Frans; Harb, Wael A; Feng, Wentao; Cahana, Ayelet; Taran, Tetiana; Lebwohl, David; Rugo, Hope S

2013-10-01

Effective treatments for hormone-receptor-positive (HR(+)) breast cancer (BC) following relapse/progression on nonsteroidal aromatase inhibitor (NSAI) therapy are needed. Initial Breast Cancer Trials of OraL EveROlimus-2 (BOLERO-2) trial data demonstrated that everolimus and exemestane significantly prolonged progression-free survival (PFS) versus placebo plus exemestane alone in this patient population. BOLERO-2 is a phase 3, double-blind, randomized, international trial comparing everolimus (10 mg/day) plus exemestane (25 mg/day) versus placebo plus exemestane in postmenopausal women with HR(+) advanced BC with recurrence/progression during or after NSAIs. The primary endpoint was PFS by local investigator review, and was confirmed by independent central radiology review. Overall survival, response rate, and clinical benefit rate were secondary endpoints. Final study results with median 18-month follow-up show that median PFS remained significantly longer with everolimus plus exemestane versus placebo plus exemestane [investigator review: 7.8 versus 3.2 months, respectively; hazard ratio = 0.45 (95% confidence interval 0.38-0.54); log-rank P NSAIs. These results further support the use of everolimus plus exemestane in this patient population. ClinicalTrials.gov #NCT00863655.

Nuclear receptors HR96 and ultraspiracle from the fall armyworm (Spodoptera frugiperda), developmental expression and induction by xenobiotics.

Science.gov (United States)

Giraudo, Maeva; Audant, Pascaline; Feyereisen, René; Le Goff, Gaëlle

2013-05-01

The fall armyworm Spodoptera frugiperda is a major polyphagous pest in agriculture and little is known on how this insect can adapt to the diverse and potentially toxic plant allelochemicals that they ingest or to insecticides. To investigate the involvement of nuclear receptors in the response of S. frugiperda to its chemical environment, we cloned SfHR96, a nuclear receptor orthologous to the mammalian xenobiotic receptors, pregnane X receptor (PXR) and constitutive androstane receptor (CAR). We also cloned ultraspiracle (USP), the ortholog of retinoid X receptor (RXR) that serves as partner of dimerization of PXR and CAR. Cloning of SfUSP revealed the presence of two isoforms, SfUSP-1 and SfUSP-2 in this species, that differ in their N-terminal region. The expression of these receptors as well as the ecdysone receptor was studied during specific steps of development in different tissues. SfHR96 was constitutively expressed in larval midgut, fat body and Malpighian tubules throughout the last two instars and pupal stage, as well as in Sf9 cells. EcR and SfUSP-2 showed peaks of expression before larval moults and during metamorphosis, whereas SfUSP-1 was mainly expressed in the pre-pupal stage. Receptor induction was followed after exposure of larvae or cells to 11 chemical compounds. SfHR96 was not inducible by the tested compounds. EcR was significantly induced by the 20-hydroxyecdysone agonist, methoxyfenozide, and SfUSP showed an increase expression when exposed to the juvenile hormone analog, methoprene. The cloning of these nuclear receptors is a first step in understanding the important capacities of adaptation of this insect pest. Copyright © 2013 Elsevier Ltd. All rights reserved.

Validation of an open-formula, diagnostic real-time PCR method for 20-hr detection of Salmonella in animal feeds

DEFF Research Database (Denmark)

Löfström, Charlotta; Hoorfar, Jeffrey

2012-01-01

A comparative study of a 20-hr, non-commercial, open-formula PCR method and the standard culture-based method NMKL 187, for detection of Salmonella, was performed according to the validation protocol from the Nordic organization for validation of alternative microbiological methods (NordVal) on 81...

Understanding deformation with high angular resolution electron backscatter diffraction (HR-EBSD)

Science.gov (United States)

Britton, T. B.; Hickey, J. L. R.

2018-01-01

High angular resolution electron backscatter diffraction (HR-EBSD) affords an increase in angular resolution, as compared to ‘conventional’ Hough transform based EBSD, of two orders of magnitude, enabling measurements of relative misorientations of 1 x 10-4 rads (~ 0.006°) and changes in (deviatoric) lattice strain with a precision of 1 x 10-4. This is achieved through direct comparison of two or more diffraction patterns using sophisticated cross-correlation based image analysis routines. Image shifts between zone axes in the two-correlated diffraction pattern are measured with sub-pixel precision and this realises the ability to measure changes in interplanar angles and lattice orientation with a high degree of sensitivity. These shifts are linked to strains and lattice rotations through simple geometry. In this manuscript, we outline the basis of the technique and two case studies that highlight its potential to tackle real materials science challenges, such as deformation patterning in polycrystalline alloys.

Effect of chronic smoking on lens nucleus as assessed by Pentacam HR lens densitometry in young adults.

Science.gov (United States)

Pekel, Gökhan; Cetin, Ebru Nevin; Acer, Semra; Yagci, Ramazan; Altintas, Seher; Ongun, Gülin Tugba

2014-06-01

To evaluate the effects of chronic tobacco smoking on lens nucleus by Pentacam HR lens densitometry (LD) in young adults. Prospective cross-sectional case series. Thirty subjects (23 M, 7 F) who were chronic cigarette smokers (≥10 cigarettes/day for at least 2 years) (group 1) and another 30 subjects (23 M, 7 F) who did not smoke (group 2), were included in this study. The patients were matched for age and sex between the groups. The exclusion criteria were any history of ocular surgery, any systemic disorders and any ocular diseases except for mild refractive disorders. Lens densitometry measurements were done with the Pentacam HR (Oculus, Wetzlar, Germany). The Schirmer test and pachymetry measurements were also performed. Mean age of the patients for both groups was 28.90 ± 8.20 years (range: 18-40 years). Mean lens densitometry (LD) measurements of Group 1 (chronic cigarette smoking group) were higher than those of Group 2 (control group) in all LD techniques; however only mean "peak" LD measurements showed a statistically significant difference between these two groups (Group 1: 8.67 ± 0.61, Group 2: 8.44 ± 0.70, p = 0.04). The mean Schirmer test value was 12.43 ± 5.60 mm in Group 1 and 13.00 ± 4.26 mm in Group 2 (p = 0.55). The mean central corneal thickness (CCT) value was 564.23 ± 34.61 µm in Group 1 and 550.47 ± 32.94 µm in Group 2 (p = 0.03). The Pentacam HR LD seems to be an important option for the evaluation of lens nucleus in young adults, because it gives objective and quantitative data. Although chronic smoking increases lens nucleus density in young adults, the effect is not statistically significant when compared with the control group.

Comparison of prognostic and predictive impact of genomic or central grade and immunohistochemical subtypes or IHC4 in HR+/HER2- early breast cancer: WSG-AGO EC-Doc Trial.

Science.gov (United States)

Gluz, O; Liedtke, C; Huober, J; Peyro-Saint-Paul, H; Kates, R E; Kreipe, H H; Hartmann, A; Pelz, E; Erber, R; Mohrmann, S; Möbus, V; Augustin, D; Hoffmann, G; Thomssen, C; Jänicke, F; Kiechle, M; Wallwiener, D; Kuhn, W; Nitz, U; Harbeck, N

2016-06-01

Potential prognostic and predictive markers in early, intermediate-risk breast cancer (BC) include histological grade, Ki-67, genomic signatures, e.g. genomic grade index (GGI), and intrinsic subtypes. Their prognostic/predictive impact in hormone receptor (HR: ER and/or PR) positive/HER2- BC is controversial. WSG-AGO EC-Doc demonstrated superior event-free survival (EFS) in patients with 1-3 positive lymph node receiving epirubicin/cyclophosphamide-docetaxel (EC-Doc) versus 5-fluoruracil/epirubicin/cyclophosphamide (FEC). In a representative trial subset, we quantify concordance among factors used for clinical chemotherapy indication. We investigate the impact of central histology (n = 772), immunohistochemistry for intrinsic subtyping and IHC4, and dichotomous (GG) or continuous (GGI) genomic grade (n = 472) on patient outcome and benefit from taxane chemotherapy, focusing on HR+/HER2- patients (n = 459). Concordance of local grade (LG) with central (CG) or genomic grade was modest. In HR+/HER2- patients, low (GG-1: 16%), equivocal (GG-EQ: 17%), and high (GG-3: 67%) GG were associated with respective 5-year EFS of 100%, 93%, and 85%. GGI was prognostic for EFS within all LG subgroups and within CG3, whereas IHC4 was prognostic only in CG3 tumors.In unselected and HR+/HER2- patients, CG3 and luminal-A-like subtype entered the multivariate EFS model, but not IHC4 or GG. In the whole population, continuous GGI entered the model [hazard ratio (H.R.) of 75th versus 25th = 2.79; P = 0.01], displacing luminal-A-like subtype; within HR+/HER2- (H.R. = 5.36; P Doc versus FEC in unselected but not in HR+/HER2- patients. In the WSG-AGO EC-Doc trial for intermediate-risk BC, CG, intrinsic subtype (by IHC), and GG provide prognostic information. Continuous GGI (but not IHC4) adds prognostic information even when IHC subtype and CG are available. Finally, the high interobserver variability for histological grade and the still missing validation of Ki-67 preclude indicating or

Analysis of the relationship between Brazilian subsidiary and U.S. corporate headquarter focused in HR management

OpenAIRE

Claudia Cristina Bitencourt; Debora Boll

2014-01-01

Multinational organizations are called agents of globalization, due their economic and social relevance. Given their complexity, by having to act globally and locally at the same time, there is a need to study their RH operation dynamic as a key point to understanding the contemporary management practices. In this scenario, this study aims to understand how the HR management is developed in those companies, when the RH area has the strategic role of attraction, development and retention of pe...

Bone Structural Changes and Estimated Strength After Gastric Bypass Surgery Evaluated by HR-pQCT

DEFF Research Database (Denmark)

Frederiksen, Katrine Diemer; Hanson, Stine; Hansen, Stinus

2016-01-01

Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment of morbid obesity, with positive effects on obesity-related complications. The treatment is associated with bone loss, which in turn might increase fracture risk. The aim of this study was to evaluate changes in bone mineral density...... (BMD) and bone architecture assessed using dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT), 6 and 12 months after RYGB, and correlate them to changes in selected biochemical markers. A prospective cohort study included 25 morbidly obese...

Sex-, Ethnic-, and Age-Specific Centile Curves for pQCT- and HR-pQCT-Derived Measures of Bone Structure and Strength in Adolescents and Young Adults.

Science.gov (United States)

Gabel, Leigh; Macdonald, Heather M; Nettlefold, Lindsay A; McKay, Heather A

2018-02-02

There are presently no adolescent centile curves for bone parameters at the tibial midshaft using peripheral quantitative computed tomography (pQCT) or at the distal radius and tibia using high-resolution pQCT (HR-pQCT). Thus, we aimed to develop sex-, ethnic-, site-, and age-specific centile curves for pQCT and HR-pQCT-derived bone outcomes for youth and young adults aged 10 to 21 years. We acquired pQCT scans (XCT3000 or XCT2000) at the tibial midshaft (50% site) and HR-pQCT scans (XtremeCT) at the distal radius (7% site) and tibia (8% site) in a convenience sample of participants in the mixed-longitudinal University of British Columbia Healthy Bones III Study. We scanned 778 10- to 21-year-olds annually for a maximum of 11 years using pQCT (413 girls, 56% Asian; 365 boys, 54% Asian; n = 3160 observations) and 349 10- to 21-year-olds annually for a maximum of 4 years using HR-pQCT (189 girls, 51% Asian; 165 boys, 50% Asian; n = 1090 observations). For pQCT, we report cortical bone mineral density (BMD), total bone cross-sectional area, and polar strength-strain index. For HR-pQCT, we report standard measures (total BMD, trabecular number, thickness, and bone volume fraction) and automated segmentation measures (total bone cross-sectional area, cortical BMD, porosity, and thickness). We applied finite element analysis to estimate failure load. We applied the lamda, mu, sigma (LMS) method using LMS ChartMaker Light (version 2.5, The Institute of Child Health, London, UK) to construct LMS tables and centile plots. We report sex- and age-specific centiles (3rd, 10th, 25th, 50th, 75th, and 97th) for whites and Asians for pQCT bone parameters at the tibial midshaft and HR-pQCT bone parameters at the distal radius and tibia. These centile curves might be used by clinicians and scientists to interpret values or better understand trajectories of bone parameters in clinical populations, those from different geographic regions or of different ethnic origins. © 2018

Patient-reported Quality of Life and Treatment Satisfaction in Patients With HR+/HER2- Advanced/Metastatic Breast Cancer.

Science.gov (United States)

Wood, Robert; Mitra, Debanjali; de Courcy, Jonathan; Iyer, Shrividya

2017-08-01

Globally, around 1.67 million new cases of breast cancer are diagnosed each year, with advanced breast cancer (ABC-Stage III) and metastatic breast cancer (MBC-Stage IV) together accounting for up to 22% of incident cases. Hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR + /HER2 - ) breast cancer comprises 66% of ABC/MBC. Understanding disease-specific health-related quality of life and patient satisfaction with treatments currently available for HR + /HER2 - ABC/MBC in clinical practice is essential for assessing potential unmet need in this patient population. Data on treatment patterns in patients with HR + /HER2 - ABC/MBC were collected from oncology practices across the United States and Europe in a cross-sectional study in a clinical practice setting, the Adelphi Real World Advanced Breast Cancer Disease Specific Programme. A subset of patients included in the study completed several self-reported tools, including the Functional Assessment of Cancer Therapy-Breast and the Cancer Therapy Satisfaction Questionnaire. Analyses were conducted using data from the overall cohort and stratified by current treatment, metastatic sites, and number of prior therapy lines. Overall, 739 patients were recruited by 173 oncologists; 83% of patients had MBC, with the balance having ABC. The majority of patients with MBC had visceral metastases without bone metastases, and similar percentages of the total study population (≈40%) were receiving chemotherapy and endocrine therapy. Patients receiving only endocrine therapy had significantly better cancer-specific quality of life than did those receiving chemotherapy. Endocrine therapy also associated with fewer concerns about side effects and higher treatment satisfaction than chemotherapy. Statistically lower scores, indicating poorer well-being, were observed in patients with both bone and visceral metastases compared with those with either bone-only or visceral-only metastases for all but the

Výborné divadlo jako hezký film aneb Archeologie filmových Hrátek s čertem

Czech Academy of Sciences Publication Activity Database

Merenus, Aleš

2016-01-01

Roč. 28, č. 2 (2016), s. 77-103 ISSN 0862-397X Institutional support: RVO:68378068 Keywords : Czech drama * Drda, Jan * Mach, Josef * Brdečka, Jiří * film adaptation * Hrátky s čertem (Playing with the Devil) * fairy tales Subject RIV: AJ - Letters, Mass-media, Audiovision

Dynamics of SARS-coronavirus HR2 domain in the prefusion and transition states

Science.gov (United States)

McReynolds, Susanna; Jiang, Shaokai; Rong, Lijun; Caffrey, Michael

2009-12-01

The envelope glycoproteins S1 and S2 of severe acute respiratory syndrome coronavirus (SARS-CoV) mediate viral entry by conformational change from a prefusion state to a postfusion state that enables fusion of the viral and target membranes. In this work we present the characterization of the dynamic properties of the SARS-CoV S2-HR2 domain (residues 1141-1193 of S) in the prefusion and newly discovered transition states by NMR 15N relaxation studies. The dynamic properties of the different states, which are stabilized under different experimental conditions, extend the current model of viral membrane fusion and give insight into the design of structure-based antagonists of SARS-CoV in particular, as well as other enveloped viruses such as HIV.

Unusual and unique distribution of anal high-risk human papillomavirus (HR-HPV among men who have sex with men living in the Central African Republic.

Directory of Open Access Journals (Sweden)

Ralph-Sydney Mboumba Bouassa

Full Text Available High-risk (HR human papillomavirus (HPV infection remains a great concern in relation to African men who have sex with men (MSM, especially those infected with HIV. The prevalence of HR-HPV and associated risk factors was estimated in a cross-sectional observational study covering MSM living in Bangui, Central African Republic.MSM receiving care at the Centre National de Référence des Infections Sexuellement Transmissibles et de la Thérapie Antirétrovirale, Bangui, were included. HIV serostatus and socio-demographic and behavioral characteristics were collected. HPV DNA was detected and genotyped on anal swabs using Anyplex™ II HPV28 test (Seegene, South Korea, and HSV DNA by in-house real-time PCR. Logistic regression analyses were used to determine risk factors associated with HPV outcomes.42 MSM (mean age, 23.2 years; range, 14-39 including 69.1% HIV-1-positive and 30.9% HIV-negative were prospectively enrolled. The prevalence of anal HPV was 69.1%, including 82.7% of HR-HPV which were multiple in 52.0%. The most prevalent genotypes were HPV-35, HPV-58, HPV-59 and HPV-31. While, HPV-16 and HPV-18 were present in a minority of samples. Multiple HR-HPV infection was more frequent in HIV-positive MSM (41.4% with 2.7 genotypes per anal samples than in HIV-negative (7.7% with 1.5 genotypes per anal samples. HPV types included in the prophylactic Gardasil-9® vaccine were detected in 68.9% of specimens and HPV-58 was the most frequently detected. MSM infected by HPV-16 and HPV-18 were all infected by HIV-1. Few anal swabs (11.9% contained HSV-2 DNA without relationship with HPV detection. Condomless receptive anal intercourse was the main risk factor to being infected with any type of HPV and condomless insertive anal intercourse was significantly less associated with HPV contamination than receptive anal intercourse (Odd ratio = 0.02.MSM in Bangui are at-risk of HIV and HR-HPV anal infections. The unusual distribution of HPV-35 as

The influence of age on the associations between HR practices and both affective commitment and job satisfaction : A meta-analysis

NARCIS (Netherlands)

Kooij, Dorien T. A. M.; Jansen, Paul G. W.; Dikkers, Josje S. E.; de lange, Annet H.

Research on the association between high commitment Human Resource (HR) practices and work-related outcomes at the individual level rarely focuses on age differences To fill this knowledge gap a meta analysis has been conducted to examine how the relationships between the availability of high

The influence of age on the associations between HR practices and both affective commitment and job satisfaction: A meta-analysis

NARCIS (Netherlands)

Kooij, T.A.M.; Jansen, P.G.W.; Dikkers, J.S.E.; de Lange, A.H.

2010-01-01

Research on the association between high commitment Human Resource (HR) practices and work-related outcomes at the individual level rarely focuses on age differences. To fill this knowledge gap, a meta-analysis has been conducted to examine how the relationships between the availability of high

Development of a Cummins ISL Natural Gas Engine at 1.4g/bhp-hr NOx + NMHC Using PLUS Technology: Final Report

Energy Technology Data Exchange (ETDEWEB)

Kamel, M. M.

2005-07-01

NREL subcontractor report describes Cummins Westport, Inc.'s development of an 8.9 L natural gas engine (320 hp, 1,000 ft-lb peak torque) with CARB emissions certification of 1.4 g/bhp-hr NOx + NMHC.

The Effect of HR Practices on Employee and Customer Satisfaction - A Study of an Airport Infrastructure Manager

OpenAIRE

Sebastiampillai, Shaleen; Holm, Victoria Urdshals

2017-01-01

Problem Statement: The aim of this study is to identify how the use of Human Resource (HR) practices are able to affect employee attitudes and behaviours, and how these in turn affect organizational performance measured as customer satisfaction. Motivation: Caused by the increased competitive market, many airports have turned to service quality as a strategy for achieving competitive advantage. For service companies, the key to make profits is by satisfying their customers. As the intera...

Fireside Corrosion Behaviors of Super304H and HR3C in Coal Ash/Gas Environment with Different SO2 Contents at 650 °C

Science.gov (United States)

Lu, Jintao; Yang, Zhen; Li, Yan; Huang, Jinyang; Zhou, Yongli; Zhao, Xinbao; Yuan, Yong

2018-05-01

The corrosion behaviors of Super304H and HR3C used for USC boiler applications were investigated in simulated coal ash/gas environments with 0.1 and 1.5% of SO2 at 650 °C for 500 h. The results indicated that the increase in SO2 accelerated the corrosion rate and the spalling tendency of the corrosion layer in both tested alloys. Fe2O3, Cr2O3 and FeCr2O4 main peaks were revealed by XRD on Super304H, but on HR3C only the Cr2O3 peak showed a high intensity. The SO2 content did not affect the corrosion product composition of any of the alloys, but accelerated the inner sulfidation and the spallation on Super304H. No obvious internal sulfidation was observed on HR3C in either SO2 content. Based on the experimental results, the alloy corrosion mechanism and the influence of sulfur content on the corrosion process were discussed.

Nuclear Waste Issues. Hearings before the Subcommittee on Energy and Power of the Committee on Energy and Commerce, US House of Representatives, One Hundredth Congress, First Session, on H.R. 2888 and H.R. 2967, June 11, 1987

International Nuclear Information System (INIS)

Anon.

1987-01-01

Proceedings of the hearings before the Subcommittee on Energy and Power of the Committee on Energy and Commerce held on two separate dates as the first sessions on bills H.R. 2888 and H.R. 2967 are recorded here. These bills would suspend certain activities of the Department of Energy (DOE) under the Nuclear Waste Policy Act of 1982 and would establish a nuclear waste policy review commission and an office of the nuclear waste negotiator. The hearings on 11 June 1987 examined the DOE's proposal to build a monitored retrievable storage facility (MRS) in Tennessee on the site of the Clinch Breeder Reactor. The General Accounting Office has questioned the adequacy of the DOE's study that recommended building the MRS. Testimony was presented by representatives of the American Nuclear Council; Community and Economic Development Division, General Accounting Office; Wisconsin Radioactive Waste Review Board; Washington Nuclear Waste Board; Sierra Club; Department of Health and Environment, State of Tennessee; Texas Nuclear Waste Programs Office; the Nuclear Regulatory Commission and the DOE. The Governor of Washington, Hon. Marilyn Lloyd, and Hon. Bart Gordon presented testimony. The concerns of the testimony were that the DOE was not ready to build the MRS - not enough study had been done to merit spending hugh amounts of money. Testimony on the two bills was not very supportive of the bills as they had been sponsored

Evaluation and Comparison of High-Resolution (HR) and High-Light (HL) Phosphors in the Micro-Angiographic Fluoroscope (MAF) using Generalized Linear Systems Analyses (GMTF, GDQE) that include the Effect of Scatter, Magnification and Detector Characteristics.

Science.gov (United States)

Gupta, Sandesh K; Jain, Amit; Bednarek, Daniel R; Rudin, Stephen

2011-01-01

In this study, we evaluated the imaging characteristics of the high-resolution, high-sensitivity micro-angiographic fluoroscope (MAF) with 35-micron pixel-pitch when used with different commercially-available 300 micron thick phosphors: the high resolution (HR) and high light (HL) from Hamamatsu. The purpose of this evaluation was to see if the HL phosphor with its higher screen efficiency could be replaced with the HR phosphor to achieve improved resolution without an increase in noise resulting from the HR's decreased light-photon yield. We designated the detectors MAF-HR and MAF-HL and compared them with a standard flat panel detector (FPD) (194 micron pixel pitch and 600 micron thick CsI(Tl)). For this comparison, we used the generalized linear-system metrics of GMTF, GNNPS and GDQE which are more realistic measures of total system performance since they include the effect of scattered radiation, focal spot distribution, and geometric un-sharpness. Magnifications (1.05-1.15) and scatter fractions (0.28 and 0.33) characteristic of a standard head phantom were used. The MAF-HR performed significantly better than the MAF-HL at high spatial frequencies. The ratio of GMTF and GDQE of the MAF-HR compared to the MAF-HL at 3(6) cycles/mm was 1.45(2.42) and 1.23(2.89), respectively. Despite significant degradation by inclusion of scatter and object magnification, both MAF-HR and MAF-HL provide superior performance over the FPD at higher spatial frequencies with similar performance up to the FPD's Nyquist frequency of 2.5 cycles/mm. Both substantially higher resolution and improved GDQE can be achieved with the MAF using the HR phosphor instead of the HL phosphor.

24 hr Whole-Body Retension of 99mTc-Methylene Diphosphonate and Osteocalcin in patients with Hyperthyroidism

International Nuclear Information System (INIS)

Yeoum, Kwang Seop; Lee, Jin Oh; Kang, Tae Woong; Lim, Sang Moo; Hong, Sung Woon

1990-01-01

The development of histomorphometric and histodynamic investigations has permitted the description of a specific and complex osteopathy in hyperthyroidism. The increased bone turnover rate in hyperthyroid patients may be accompanied by a considerable bone loss. These features are associated with both increased osteoclastic bone resorption and increased osteoclastic bone formation, with an accelerated calcification rate. Conventional biochemical markers of bone metabolism, i.e. serum calcium and alkaline phosphatase and urinary hydroxyproline and calcium are normal in most patients with hyperthyroidism. However, the correlation between serum BGP and serum concentration of thyroid hormon suggests that serum BGP may be a sensitive marker of increased bone formation due to the hypersecretion of thyroid hormones. Any increase in bone turnover, whether focal or diffuse, will result in an increase in 99m Tc-methylenediphosphonate uptake (MDP). The measurement of this uptake in hyperthyroid patients by bone provides a sensitive and objective means of quantifying skeletal metabolism. Using a standard shadow-shield whole-body monitor and radioimmunoassay kit, we have measured whole-body retention of 99m Tc-MDP up to 24 hr and concentration of serum Osteocalcin in 20 patients with hyperthyroidism and in 42 normals. The results were as follows; 1) The average of serum Osteocalcin level in 42 patients with normals was 9.90 ± 4.87(ng/ml) and in 20 patients with hyperthyroidism was 19.54 ± 5.7(ng/ml). Both the averages of serum Osteocalcin and 24 hr 99m Tc-MDP uptakes in hyperthyroid patients were higher than those in normals. 2) 99m Tc-MDP uptakes in skeletal system increased in proportion to normal ageing after 40 yrs old in 42 patients with normals. The average of 99m Tc-MDP uptakes in hyperthyroid patients were higher than those in normals without related ageing. 3) A significant relationships between the 99m Tc-MDP uptakes and serum Osteocalcin level were performed (r=0

PLEIADES-HR SYSTEM PRODUCTS PERFORMANCE AFTER IN-ORBIT COMMISSIONING PHASE

Directory of Open Access Journals (Sweden)

C. Panem

2012-07-01

Full Text Available Launched on 2011, December 16th by the second Soyuz operated in French Guiana, PLEIADES-HR acquired its first high resolution images 3 days after. The PLEIADES program is a space Earth Observation system led by the French Space Agency (CNES, it provides the first european high resolution satellite which will simultaneously acquire in Panchromatic and Multi- Spectral modes 20 km wide images with a 70 cm nadir resolution. Imaging capabilities have been highly optimized in order to acquire, in the same pass, along-track mosaics, stereo pairs and triplets, and multi-targets. Ground segment processes automatically data to ensure operational requirements and quick access to images for the users. Since ground processing capabilities have been taken into account very early in the mission development, it has been possible to relax some costly on-board components requirements, in order to achieve a cost effective on-board/ground compromise. Starting from the PLEIADES system and on board characteristics, this paper first presents an overview of ground segment functional breakdown. Then it focuses more precisely on the different levels of products and associated processing performances. Finally the paper shows how appropriate ground processing systems allowed CNES Image Quality team to assess radiometric and geometric performances during the 6 first months of PLEIADES 1A.

Determination of lead in rice grains by solid sampling HR-CS GFAAS.

Science.gov (United States)

Gunduz, Sema; Akman, Suleyman

2013-12-01

A study was performed for the determination of lead in rice grains directly by solid sampling high resolution continuum source graphite furnace atomic absorption spectrometry (HR-CS GFAAS) without digesting sample. The effects of sample amount, pyrolysis/atomization temperatures on the determination of lead in rice were investigated and optimized using a certificated rice flour. The lead concentrations were determined applying 800 °C of pyrolysis and 1800 °C of atomization temperatures without modifier. LOD (N=10, 3σ) and characteristic mass were 2.3 μg kg(-1) and 8.1 pg, respectively. The certified lead value of a rice flour CRM was found in its uncertainity limits. The lead contents of various rice samples obtained from markets in Turkey were between 0.009 and 0.162 mg kg(-1) which are in acceptable range. The average lead concentrations in various rice grains taken from the same package were significantly different from each other. Copyright © 2013 Elsevier Ltd. All rights reserved.

Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c.

NARCIS (Netherlands)

Qiao, Q.; Dekker, J.M.; Vegt, F. de; Nijpels, G.; Nissinen, A.; Stehouwer, C.D.A.; Bouter, L.M.; Heine, R.J.; Tuomilehto, J.

2004-01-01

OBJECTIVE: To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality. STUDY DESIGN AND SETTING: A joint analysis of two prospective studies with baseline glycemia measurements. RESULTS: The multivariate adjusted hazard ratios (HRs)

Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbA1c

NARCIS (Netherlands)

Qiao, Qing; Dekker, Jacqueline M; de Vegt, Femmie; Nijpels, Giel; Nissinen, Aulikki; Stehouwer, Coen D A; Bouter, Lex M; Heine, Robert J; Tuomilehto, Jaakko

OBJECTIVE: To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality. STUDY DESIGN AND SETTING: A joint analysis of two prospective studies with baseline glycemia measurements. RESULTS: The multivariate adjusted hazard ratios (HRs)

Assessing the intake of obesity-related foods and beverages in young children: comparison of a simple population survey with 24 hr-recall

Directory of Open Access Journals (Sweden)

Bell Andrew C

2009-10-01

Full Text Available Abstract Background With an increasing focus on obesity prevention there is a need for simple, valid tools to assess dietary indicators that may be the targets of intervention programs. The objective of this study was to determine the relative validity of previous day dietary intake using a newly developed parent-proxy questionnaire (EPAQ for two to five year old children. Methods A convenience sample of participants (n = 90 recruited through preschools and the community in Geelong, Australia provided dietary data for their child via EPAQ and interviewer-administered 24-hour dietary recall (24 hr-recall. Comparison of mean food and beverage group servings between the EPAQ and 24 hr-recall was conducted and Spearman rank correlations were computed to examine the association between the two methods. Results Mean servings of food/beverage groups were comparable between methods for all groups except water, and significant correlations were found between the servings of food and beverages using the EPAQ and 24-hr recall methods (ranging from 0.57 to 0.88. Conclusion The EPAQ is a simple and useful population-level tool for estimating the intake of obesity-related foods and beverages in children aged two to five years. When compared with 24-hour recall data, the EPAQ produced an acceptable level of relative validity and this short survey has application for population monitoring and the evaluation of population-based obesity prevention interventions for young children.

First-line treatment disruption among post-menopausal women with HR+/HER2- metastatic breast cancer: a retrospective US claims study.

Science.gov (United States)

Tang, Derek H; Li, Nanxin; Du, Ella X; Peeples, Miranda; Chu, Lihao; Xie, Jipan; Barghout, Victoria

2017-12-01

This study assessed disruption of first-line treatments initiated after the approval of the first CDK 4/6 inhibitor, palbociclib, among post-menopausal women with HR+/HER2- metastatic breast cancer (mBC) in the US. Post-menopausal women with HR+/HER2- mBC who initiated first-line endocrine therapy or chemotherapy (index therapy) between February 3, 2015 (palbociclib approval date) and February 29, 2016 (end of data) were identified from the Symphony Source Lx database. Patients were required to have continuous quarterly activity (defined as ≥1 pharmacy or medical claim) for 12 months prior to and 1 month after the initiation of the index therapy (index date). Treatment disruption was defined as a treatment gap of ≥60 days or adding an agent after the original therapy. Kaplan-Meier analyses were conducted to estimate treatment disruption rates during the 6 months following the index date. Patients without treatment disruption were censored at the end of continuous quarterly activity or end of data. A total of 8,160 and 2,153 eligible patients initiated endocrine therapy or chemotherapy as their first-line mBC treatment, with a median follow-up of 6.7 and 7.6 months, respectively. The three most prevalent metastatic sites were bone (28.1-42.2%), liver (8.8-17.3%), and lung (8.6-9.5%). Overall, 37.7% (n = 3,074) of patients receiving endocrine therapy and 86.1% (n = 1,852) of patients receiving chemotherapy encountered treatment disruption at 6 months (log-rank test p disruption rates of first-line therapies were sub-optimal among post-menopausal women with HR+/HER2- mBC, primarily driven by chemotherapy users. New therapies or interventions are needed to reduce treatment disruption in this patient population.

Object Permanence After a 24-Hr Delay and Leaving the Locale of Disappearance: The Role of Memory, Space, and Identity

Science.gov (United States)

Moore, M. Keith; Meltzoff, Andrew N.

2004-01-01

Fourteen-month-old infants saw an object hidden inside a container and were removed from the disappearance locale for 24 hr. Upon their return, they searched correctly for the hidden object, demonstrating object permanence and long-term memory. Control infants who saw no disappearance did not search. In Experiment 2, infants returned to see the…

From SPOT 5 to Pleiades HR: evolution of the instrumental specifications

Science.gov (United States)

Rosak, A.; Latry, C.; Pascal, V.; Laubier, D.

2017-11-01

Image quality specifications should aimed to fulfil high resolution mission requirements of remote sensing satellites with a minimum cost. The most important trade-off to be taken into account is between Modulation Transfer Function, radiometric noise and sampling scheme. This compromise is the main driver during design optimisation and requirement definition in order to achieve good performances and to minimise the mission cost. For the SPOT 5 satellite, a new compromise had been chosen. The supermode principle of imagery (sampling at 2.5 meter with a pixel size of 5 meter) imp roves the resolution by a factor of four compared with the SPOT 4 satellite (10 meter resolution). This paper presents the image quality specifications of the HRG-SPOT 5 instrument. We introduce all the efforts made on the instrument to achieve good image quality and low radiometric noise, then we compare the results with the SPOT 4 instrument's performances to highlight the improvements achieved. Then, the in-orbit performance will be described. Finally, we will present the new goals of image quality specifications for the new Pleiades-HR satellite for earth observation (0.7 meter resolution) and the instrument concept.

100-HR-1 Operable Unit focused feasibility study report. Draft A

International Nuclear Information System (INIS)

1994-09-01

The standard Comprehensive Environmental Response, Compensation, and Liability Act of 1980 Feasibility Study (FS) includes development and screening of alternatives (phases 1 and 2) and the detailed analysis of alternatives (phase 3). This focused feasibility study (FFS) constitutes the phase 3 portion of the FS process. The FFS process is conducted in two stages, a Process Document (DOE-RL 1994a) and an operable unit-specific FFS document, such as this one. The FFS process is performed by implementing a ''plug-in'' style approach as defined in great detail in the Process Document. The objective of this operable unit-specific FFS is to provide decision makers with sufficient information to allow appropriate and timely selection of interim remedial measures (IRM) for sites associated with the 100-HR-1 Operable Unit. The IRM candidate waste sites are determined in the limited field investigation. Site profiles are developed for each of these waste sites. The site profiles are used in the application of the plug-in approach. The waste site either plugs into the analysis of the alternatives for the group, or deviations from the developed group alternatives are described and documented

The HIPAA privacy rule and HR/benefits outsourcing: does the business associate label belong on your recordkeeper?

Science.gov (United States)

Hilger, Denise D

2004-01-01

Employers that sponsor group health plans and serve as the plan administrator of those plans are required by the HIPAA Privacy Rule to execute business associate contracts with vendors that provide services on behalf of the plans. The business associate contracts must contain many specific provisions regarding the protection, use and disclosure of health information. This article looks at the implications of imposing business associate contract obligations on an integrated HR and benefits-outsourcing recordkeeper and cautions employers against an overly broad application of the requirements.

Bone structure assessed by HR-pQCT, TBS and DXL in adult patients with different types of osteogenesis imperfecta.

Science.gov (United States)

Kocijan, R; Muschitz, C; Haschka, J; Hans, D; Nia, A; Geroldinger, A; Ardelt, M; Wakolbinger, R; Resch, H

2015-10-01

Bone microarchitecture by high-resolution peripheral quantitative computed tomography (HR-pQCT) was assessed in adult patients with mild, moderate, and severe osteogenesis imperfecta (OI). The trabecular bone score (TBS), bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA), and dual X-ray and laser (DXL) at the calcaneus were likewise assessed in patients with OI. Trabecular microstructure and BMD in particular were severely altered in patients with OI. OI is characterized by high fracture risk but not necessarily by low BMD. The main purpose of this study was to assess bone microarchitecture and BMD at different skeletal sites in different types of OI. HR-pQCT was performed in 30 patients with OI (mild OI-I, n = 18 (41.8 [34.7, 55.7] years) and moderate to severe OI-III-IV, n = 12 (47.6 [35.3, 58.4] years)) and 30 healthy age-matched controls. TBS, BMD by DXA at the lumbar spine and hip, as well as BMD by DXL at the calcaneus were likewise assessed in patients with OI only. At the radius, significantly lower trabecular parameters including BV/TV (p = 0.01 and p < 0.0001, respectively) and trabecular number (p < 0.0001 and p < 0.0001, respectively) as well as an increased inhomogeneity of the trabecular network (p < 0.0001 and p < 0.0001, respectively) were observed in OI-I and OI-III-IV in comparison to the control group. Similar results for trabecular parameters were found at the tibia. Microstructural parameters were worse in OI-III-IV than in OI-I. No significant differences were found in cortical thickness and cortical porosity between the three subgroups at the radius. The cortical thickness of the tibia was thinner in OI-I (p < 0.001), but not OI-III-IV, when compared to controls. Trabecular BMD and trabecular bone microstructure in particular are severely altered in patients with clinical OI-I and OI-III-IV. Low TBS and DXL and their significant associations to HR-pQCT parameters of trabecular bone support this conclusion.

Development of methodologies used in the areas of safeguards and nuclear forensics based on LA-HR-ICP-MS technique; Desenvolvimento de metodologias utilizadas nas areas de salvaguardas e forense nuclear baseadas na tecnica LA-HR-ICP-MS

Energy Technology Data Exchange (ETDEWEB)

Marin, Rafael Coelho

2013-07-01

Environmental sampling performed by means of swipe samples is a methodology frequently employed by International Atomic Energy Agency (IAEA) to verify if the signatory States of the Safeguards Agreements are conducing unauthorized activities. Swipe samples analysis is complementary to the Safeguards ordinary procedures used to verify the information given by the States. In this work it was described a methodology intending to strengthen the nuclear safeguards and nuclear forensics procedures. The proposal is to study and evaluate the laser ablation high resolution inductively coupled plasma mass spectrometry (LA-HR-ICP-MS) technique as an alternative to analyze the real-life swipe samples. The precision achieved through the standard (CRM - 125A) measurements, represented by the relative standard deviation (RSD), was respectively 1.3 %, 0.2 % e 7.6 % for the {sup 234}U/{sup 238}U, {sup 235}U/{sup 238}U e {sup 236}U/{sup 238}U isotopes ratios. The percent uncertainties (u %), which covers the RSD, ranged from 3.5 % to 29.8 % to the {sup 235}U/{sup 238}U measurements and from 16.6 % to 42.9 % to the {sup 234}U/{sup 238}U isotope ratio. These results were compatible with former studies performed by the LA-HR-ICP-MS that analyzed real-life swipe samples collected at a nuclear facility. Swipe samples collected from several points of the nuclear facility presented enrichment level ranging from (2.3 ± 0.7) % (sample 3) to (17.3 ± 2.8) % (sample 18). They also allowed detecting different enrichment levels within the facility. (author)

24 hr Whole-Body Retension of {sup 99m}Tc-Methylene Diphosphonate and Osteocalcin in patients with Hyperthyroidism

Energy Technology Data Exchange (ETDEWEB)

Yeoum, Kwang Seop; Lee, Jin Oh; Kang, Tae Woong; Lim, Sang Moo; Hong, Sung Woon [Korea Cancer Center Hospital, Seoul (Korea, Republic of)

1990-07-15

The development of histomorphometric and histodynamic investigations has permitted the description of a specific and complex osteopathy in hyperthyroidism. The increased bone turnover rate in hyperthyroid patients may be accompanied by a considerable bone loss. These features are associated with both increased osteoclastic bone resorption and increased osteoclastic bone formation, with an accelerated calcification rate. Conventional biochemical markers of bone metabolism, i.e. serum calcium and alkaline phosphatase and urinary hydroxyproline and calcium are normal in most patients with hyperthyroidism. However, the correlation between serum BGP and serum concentration of thyroid hormon suggests that serum BGP may be a sensitive marker of increased bone formation due to the hypersecretion of thyroid hormones. Any increase in bone turnover, whether focal or diffuse, will result in an increase in {sup 99m}Tc-methylenediphosphonate uptake (MDP). The measurement of this uptake in hyperthyroid patients by bone provides a sensitive and objective means of quantifying skeletal metabolism. Using a standard shadow-shield whole-body monitor and radioimmunoassay kit, we have measured whole-body retention of {sup 99m}Tc-MDP up to 24 hr and concentration of serum Osteocalcin in 20 patients with hyperthyroidism and in 42 normals. The results were as follows; 1) The average of serum Osteocalcin level in 42 patients with normals was 9.90 +- 4.87(ng/ml) and in 20 patients with hyperthyroidism was 19.54 +- 5.7(ng/ml). Both the averages of serum Osteocalcin and 24 hr {sup 99m}Tc-MDP uptakes in hyperthyroid patients were higher than those in normals. 2) {sup 99m}Tc-MDP uptakes in skeletal system increased in proportion to normal ageing after 40 yrs old in 42 patients with normals. The average of {sup 99m}Tc-MDP uptakes in hyperthyroid patients were higher than those in normals without related ageing. 3) A significant relationships between the {sup 99m}Tc-MDP uptakes and serum

Validation summary report for the 100-HR-3 Groundwater Round 9 Phase 1 and 2

International Nuclear Information System (INIS)

1996-02-01

This report presents a summary of data validation results on groundwater samples collected for the 100-HR-3 Groundwater Round 9-Phase I and II Project. The analyses performed for this project were as follows: Metals--inductively coupled plasma (ICP) metals (filtered and unfiltered); General Chemistry--anions (fluoride, chloride, nitrate, nitrite, phosphate, and sulfate), turbidity, ammonia, nitrate+nitrite, and sulfide; and Radiochemistry--gross alpha, gross beta, technetium-99, tritium, and uranium-234/235/238. The objectives of this project were to validate sample detection limit as defined in the data validation procedures (WHC 1993). In addition, this report provides a summary of the data as defined by laboratory performance criteria and project-specific data quality objectives

Spectrophotometry of the Hα region in the spectrum of HR 1099 during the February 1978 radio flare

International Nuclear Information System (INIS)

Fraquelli, D.A.

1978-01-01

Spectrophotometry of the Hα emission line in the spectrum of HR 1099 (=HD 22468=V711 Tauri) was obtained during the radio flare of February 1978. The profiles observed during the flare have higher peak intensities and larger equivalent widths than profiles obtained outside of the flare at approximately the same orbital phases. Both the general shapes of the profiles and the equivalent widths appear to correlate with the radio flux. A preflare profile exhibits a flare-type profile, suggesting that radio outbursts in RS CVn systems may be preceded by Hα enhancement

A putative non-hr origin of DNA replication in the HindIII-K fragment of Autographa californica multiple nucleocapsid nuclear polyhedrosis virus

NARCIS (Netherlands)

Kool, M.; Goldbach, R. W.; Vlak, J. M.

1994-01-01

In addition to the seven known homologous regions (hrs) of Autographa californica multiple nucleocapsid polyhedrosis virus (AcMNPV) the HindIII-K fragment was also found to carry a putative ori, although this fragment does not contain an hr. Deletion analysis showed that this ori contains several

HR Outsourcing - využití na současném trhu práce (případ středně velké společnosti)

OpenAIRE

Moravcová, Hana

2009-01-01

This master thesis discusses the possibilities of outsourcing (in Czech also displacement of activities) in a human resources area, it also considers its forms and applications in companies. The main goal is to determine whether and to what extent HR outsourcing is worth to be implemented into small to medium sized companies and what steps are needed to be done to benefit from HR outsourcing. The work is divided into two parts. The first part is based on theoretical foundations. It contains a...

THE PRESENCE OF EQUAL OPPORTUNITIES IN HR MANAGEMENT

Directory of Open Access Journals (Sweden)

Eva Farkas

2014-07-01

Full Text Available Ensuring equal opportunities is a priority for CEO-s and decision makers, however, it is often not put into practice. Changes in recent years along with the priorities of the EU and the efforts made to banish discrimination becoming more prominent brought with themselves a pressure on firms to provide equal opportunities for the different under-privileged social groups. In Hungary the Act CXXV of 2003 on discrimination and equal opportunities lists the groups in need of protection. The law requires employers with more than fifty employees to have an equal opportunities program. In spite of this, these programs are often general and do not implement the changes and goals identified after the assessment. Still, strategies and plans are only worth how much of them are realized. Our article is about the conscious principles of the Hungarian business sector about equality and whether there are regional differences. We compare answers given by both employers and employees on the subject of the extent to which the above mentioned principles are realized by the management and whether the employees experience these changes. Our theory is that the prioritisation of equal opportunities in firms is more the result of access to project funds than that of inner initiative from the firm's management. We analyse our research questions using a quantitative method on a regionally representative national sample. We examined 992 firms with special attention on those and their employees who had some sort of written guidelines on equal opportunities and plans on implementing these. In our paper we give a short review on the importance of equal opportunities, it's manifestation in HR management and it's written declaration, the so called Equal Opportunities Plan (EOP. The efforts of the EU and access to financial resources for the EU projects as a condition our hypotheses are that (1 at least 30% of the firms studied have written guidelines or declaration on equal

HR-TEM and FT-Raman dataset of the caffeine interacted Phe–Phe peptide nanotube for possible sensing applications

OpenAIRE

Narayanan, A. Lakshmi; Dhamodaran, M.; Solomon, J. Samu; Karthikeyan, B.; Govindhan, R.

2017-01-01

Sensing ability of caffeine interaction with Phe-Phe annotates (PNTs), is presented (Govindhan et al., 2017; Karthikeyan et al., 2014; Tavagnacco et al., 2013; Kennedy et al., 2011; Wang et al., 2017) [1–5] in this data set. Investigation of synthesized caffeine carrying peptide nanotubes are carried out by FT-Raman spectral analysis and high resolution transmission electron microscopy (HR-TEM). Particle size of the caffeine loaded PNTs is < 40 nm. The FT-Raman spectrum signals are enhanced i...

The impact of caffeine consumption during 50 hr of extended wakefulness on glucose metabolism, self-reported hunger and mood state.

Science.gov (United States)

Grant, Crystal L; Coates, Alison M; Dorrian, Jillian; Paech, Gemma M; Pajcin, Maja; Della Vedova, Chris; Johnson, Kayla; Kamimori, Gary H; Fidock, Justin; Aidman, Eugene; Banks, Siobhan

2018-03-27

Caffeine is known for its capacity to mitigate performance decrements. The metabolic side-effects are less well understood. This study examined the impact of cumulative caffeine doses on glucose metabolism, self-reported hunger and mood state during 50 hr of wakefulness. In a double-blind laboratory study, participants were assigned to caffeine (n = 9, 6M, age 21.3 ± 2.1 years; body mass index 21.9 ± 1.6 kg/m 2 ) or placebo conditions (n = 8, 4M, age 23.0 ± 2.8 years; body mass index 21.8 ± 1.6 kg/m 2 ). Following a baseline sleep (22:00 hours-08:00 hours), participants commenced 50 hr of sleep deprivation. Meal timing and composition were controlled throughout the study. Caffeine (200 mg) or placebo gum was chewed for 5 min at 01:00 hours, 03:00 hours, 05:00 hours and 07:00 hours during each night of sleep deprivation. Continual glucose monitors captured interstitial glucose 2 hr post-breakfast, at 5-min intervals. Hunger and mood state were assessed at 10:00 hours, 16:30 hours, 22:30 hours and 04:30 hours. Caffeine did not affect glucose area under the curve (p = 0.680); however, glucose response to breakfast significantly increased after 2 nights of extended wakefulness compared with baseline (p = 0.001). There was a significant main effect of day, with increased tiredness (p performance under conditions of sleep deprivation by reducing feelings of tiredness, mental exhaustion and irritability without exacerbating glucose metabolism and feelings of hunger. © 2018 European Sleep Research Society.

Extensive FE-SEM/EDS, HR-TEM/EDS and ToF-SIMS studies of micron- to nano-particles in anthracite fly ash

Energy Technology Data Exchange (ETDEWEB)

Ribeiro, Joana [Centro de Geologia, Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto (Portugal); DaBoit, Kátia [Institute of Environmental Research and Human Development, IPADHC, Capivari de Baixo, Santa Catarina (Brazil); Flores, Deolinda [Centro de Geologia, Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto (Portugal); Departamento de Geociências, Ambiente e Ordenamento do Território, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, 687, 4169-007 Porto (Portugal); Kronbauer, Marcio A. [Laboratory of Environmental Researches and Nanotechnology Development, Centro Universitário La Salle, Victor Barreto, 2288 Centro 92010-000, Canoas, RS (Brazil); Silva, Luis F.O., E-mail: felipeqma@hotmail.com [Laboratory of Environmental Researches and Nanotechnology Development, Centro Universitário La Salle, Victor Barreto, 2288 Centro 92010-000, Canoas, RS (Brazil); Environmental Science and Nanotechnology Department, Catarinense Institute of Environmental Research and Human Development, IPADHC, Capivari de Baixo, Santa Catarina (Brazil)

2013-05-01

The generation of anthropogenic carbonaceous matter and mixed crystalline/amorphous mineral ultrafine/nano-particles in the 1 to 100 nm size range by worldwide coal power plants represents serious environmental problems due to their potential hazards. Coal fly ash (CFA) that resulted from anthracite combustion in a Portuguese thermal power plant was studied in this work. The physico-chemical characterization of ultrafine/nano-particles present in the CFA samples and their interaction with environment are the aim of this study. The methodologies applied for this work were field emission scanning electron microscopy (FE-SEM) with energy dispersive X-ray spectroscopy (EDS), high-resolution transmission electron microscopy with energy dispersive X-ray spectroscopy (HR-TEM/EDS) and time of flight secondary ion mass spectrometry (ToF-SIMS). Some hazardous volatile elements, C, N, S and Hg contents were also determined in the studied samples. Generally, the CFA samples comprise carbonaceous, glassy and metallic solid spheres with some containing mixed amorphous/crystalline phases. The EDS analysis coupled with the FE-SEM and HR-TEM observations of the fly ash particles with 100 to 0.1 nm demonstrates that these materials contain a small but significant proportion of encapsulated HVEs. In addition, the presence of abundant multi-walled carbon nanotubes (MWCNTs) and amorphous carbon particles, both containing hazardous volatile elements (HVEs), was also evidenced by the FE-SEM/EDS and HR-TEM/EDS analysis. A wide range of organic and inorganic compounds was determined by chemical maps obtained in ToF-SIMS analysis. - Highlights: ► We examine changes in the level of ultrafine and nanoparticles of coal mining. ► Increasing geochemical information will increase human health information in this area. ► Electron bean and Tof-SIMS increase area information.

Triage of HR-HPV positive women with minor cytological abnormalities: a comparison of mRNA testing, HPV DNA testing, and repeat cytology using a 4-year follow-up of a population-based study.

Science.gov (United States)

Persson, Maria; Elfström, K Miriam; Brismar Wendel, Sophia; Weiderpass, Elisabete; Andersson, Sonia

2014-01-01

Expression of the viral E6/E7 oncogenes of high-risk human papillomaviruses (HR-HPV) is necessary for malignant conversion and maintenance in cervical tissue. In order to determine whether HR-HPV E6/E7 mRNA testing more effectively predicts precancerous lesions and invasive cervical cancer than HR-HPV DNA testing, we aimed to compare triage using HR-HPV E6/E7 mRNA testing by APTIMA HPV Assay (APTIMA) to HPV16 DNA testing, HPV16/18 DNA testing, and repeat cytology. Liquid-based (PreservCyt) cell samples were obtained from HR-HPV-positive women diagnosed with atypical squamous cells of undetermined significance (ASCUS) and low-grade squamous intraepithelial lesions (LSIL) within the framework of the population-based cervical cancer screening program in Stockholm, Sweden. Samples were tested for HR-HPV E6/E7 mRNA by APTIMA (Gene-Probe Inc., San Diego, CA, USA). Women were followed up for 4 years after the index cytology via medical and laboratory records, and the Stockholm Oncology Center. Nine of 25 (36%) women in the ASCUS group, and 64 of 180 (36%) women in the LSIL group developed cervical intraepithelial neoplasia (CIN) grade 2 or worse during 4 years of follow-up. 162 (74%) women were APTIMA-positive, and APTIMA had the highest sensitivity to predict CIN2 or worse and CIN3 or worse in the ASCUS (77.8% and 100%) and LSIL (78.1 and 75.8%) groups, although specificity was insufficient (cytology were more specific than APTIMA. The results of this population-based study with comprehensive follow-up support the use of APTIMA as a triage test for women with ASCUS. More focused investigation is required for women with LSIL.

Role of high resolution contrast-enhanced magnetic resonance angiography (HR CeMRA) in management of arterial complications of the renal transplant

International Nuclear Information System (INIS)

Ismaeel, M. Maged; Abdel-Hamid, Azza

2011-01-01

Introduction: Transplant renal artery (RA) stenosis (TRAS) is the most frequent posttransplantation vascular complication. Contrast enhanced magnetic resonance (CeMRA) angiography has been established as the preferred imaging technique for the evaluation of TRAS because it does not require the use of iodinated contrast material and does not expose the patient to ionizing radiation. Digital subtraction angiography (DSA) is the gold standard in the evaluation of arterial tree of the renal allograft. Aim of the work: This study was carried out to assess the accuracy of CeMRA in the detection of arterial complications after renal transplantation. Patients and methods: Thirty renal transplant patients with suspected arterial complications in which both CeMRA and DSA were performed were included in the study. The HR CeMRA shows 93.7% sensitivity, 80% specificity, 88.2% positive predictive value, 88.9% negative predictive value and 88.5% accuracy. Conclusion: HR CeMRA is an accurate reliable tool in the assessment of arterial complications after renal transplantation. It may replace DSA as a diagnostic modality with reservation of interventional techniques for endovascular treatment of suitable cases.

Role of high resolution contrast-enhanced magnetic resonance angiography (HR CeMRA) in management of arterial complications of the renal transplant

Energy Technology Data Exchange (ETDEWEB)

Ismaeel, M. Maged [Suez Canal University (Egypt); Abdel-Hamid, Azza, E-mail: azza4951@hotmail.com [Suez Canal University (Egypt)

2011-08-15

Introduction: Transplant renal artery (RA) stenosis (TRAS) is the most frequent posttransplantation vascular complication. Contrast enhanced magnetic resonance (CeMRA) angiography has been established as the preferred imaging technique for the evaluation of TRAS because it does not require the use of iodinated contrast material and does not expose the patient to ionizing radiation. Digital subtraction angiography (DSA) is the gold standard in the evaluation of arterial tree of the renal allograft. Aim of the work: This study was carried out to assess the accuracy of CeMRA in the detection of arterial complications after renal transplantation. Patients and methods: Thirty renal transplant patients with suspected arterial complications in which both CeMRA and DSA were performed were included in the study. The HR CeMRA shows 93.7% sensitivity, 80% specificity, 88.2% positive predictive value, 88.9% negative predictive value and 88.5% accuracy. Conclusion: HR CeMRA is an accurate reliable tool in the assessment of arterial complications after renal transplantation. It may replace DSA as a diagnostic modality with reservation of interventional techniques for endovascular treatment of suitable cases.

Abundance analysis from the UV spectrum of the He-w star HR 6000

International Nuclear Information System (INIS)

Castelli, F.; Cornachin, M.; Morossi, C.; Hack, M.

1984-01-01

A high resolution spectrum of the He-w star HR 6000, covering the SW and LW regions, has been analysed. A fully line-blanketed model atmosphere with parameters Tsub(e) = 14000 K, log g = 4, microturbulence xi = 2 km.s -1 has been adopted. This model is in agreement with the photometric data and yields the same abundance for the Fe II and Fe III ions. By using the synthetic spectrum method we compared the observed lines with the computed ones. We find an underabundance of C, Al Si, Mg, S, Sc, Co, Ni, Zn and an overabundance of Be, P, Cl, Ti, Mn, Fe, Ga. B, O, Cr have nearly solar abundances. Circumstellar (or interstellar) shortward-shifted components affect the strong resonance lines of the following ions: C II(1) lambda 1334.535, O I(2) lambda 1302.074,Mg II(1) lambda 2795.523, lambda 2802.698, Si II(3) lambda 1304.369, Fe II(1) lambda 2599.395

Work – Life Balance Practices in Romanian Organisations – A Pilot Study Conducted on HR Professionals

Directory of Open Access Journals (Sweden)

Ramona IGREȚ

2016-06-01

Full Text Available Work – life balance is becoming a very debated subject in the Romanian business context, especially in multinationals and large Romanian companies. This paper’s main objective is to conduct a pilot study regarding work – life balance practices on human resource professionals from Romania. The study’s main purpose is to validate a research questionnaire in order to conduct a more significant research in the future. The questionnaire was applied on 52 HR specialists from different organisations and is structured on five sections: working hours, WLB practices, holiday and time off, flexible working and information about the employer and the job.

Isotope ratio measurements of uranium by LA-HR-ICP-MS

Energy Technology Data Exchange (ETDEWEB)

Marin, Rafael C.; Sarkis, Jorge E.S., E-mail: rafael.marin@usp.b, E-mail: jesarkis@ipen.b [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

2011-07-01

This work describes the utilization of Laser Ablation High Resolution Inductively Mass Spectrometry (LA-HR-ICP-MS) technique for the determination of uranium isotope composition in a UO{sub 2} pellet (CRM -125A) supplied and certified by the New Brunswick Laboratory (NBL). To carry out the adjustments of the parameters was used a glass standard NIST 610, supplied and certified by National Institute of Standards and Technology (NIST). The precision of the measurements were improved by adjusting the following parameters: RF power, laser beam diameter, defocusing of laser beam, laser energy, laser energy-density, auxiliary gas and sample gas. The measurements were performed on a continuous ablation with low energy density and defocusing, which demonstrated to be the optimum to reach the best signal stability. Isotope ratios, {sup 234}U/{sup 238}U, {sup 235}U/{sup 238}U and {sup 236}U/{sup 238}U were measured, reaching relative standard deviations (RSD) from 1.55% to 7.60%. The parameters which caused the greatest impact in order to improve the signal stability were RF power, defocusing and laser beam diameter. The results presented by the measurements revealed that the Laser ablation ICP-MS technique offers a rapid and accurate way to perform uranium isotope ratios without any sample preparation, since it allows carrying out the measurements straight on the sample, besides to preserve the testimony that is very important for safeguards and nuclear forensics purposes. (author)

Pay and Representation of Racial/Ethnic Minorities in Higher Education Administrative Positions: The Century So Far. A CUPA-HR Research Brief

Science.gov (United States)

Bichsel, Jacqueline; McChesney, Jasper

2017-01-01

The pay gap between minority men and White men has remained virtually unchanged since 1980, with Hispanic men currently earning 69 cents and Black men currently earning 73 cents on the dollar that White men earn. The pay gap is even greater for minority women. The College and University Professional Association for Human Resources (CUPA-HR) has…

Use of HbA1c for Diagnoses of Diabetes and Prediabetes: Comparison with Diagnoses Based on Fasting and 2-Hr Glucose Values and Effects of Gender, Race, and Age

Science.gov (United States)

Moellering, Douglas R.

2014-01-01

Abstract Background: Glycated hemoglobin (HbA1c) has been advocated for the diagnosis of diabetes and prediabetes. Its performance has been commonly assessed in corroboration with elevated fasting plasma glucose (FPG), but not the combination of FPG and 2-hr glucose values. This study assesses receiver operating characteristics (ROC) curves of HbA1c pertaining to the diagnoses of prediabetes and diabetes by FPG and/or 2-hr glucose, and the effects of age, gender, and race. Methods: We assessed the utility of HbA1c for diagnosing diabetes and prediabetes among 5395 adults without known diabetes from the National Health and Nutrition Examination Survey (NHANES) 2005–2010. Results: Current cutoffs of HbA1c for diabetes (6.5%) or prediabetes (5.7%) exhibited low sensitivity (0.249 and 0.354, respectively) and high specificity in identifying patients diagnosed using both FPG and 2-hr glucose, resulting in large false-negative rates (75.1% and 64.9%). Misdiagnosis rates increased with age and in non-Hispanic whites and Mexican Americans. When HbA1c was combined with FPG for diagnoses, the false-negative rate remained high for diabetes (45.7%), but was reduced for prediabetes (9.2%). Conclusions: When assessed against diagnoses using both FPG and 2-hr glucose, HbA1c had low sensitivity and high specificity for identifying diabetes and prediabetes, which varied as a function of age and race. Regarding recently released American Diabetes Association (ADA) and joint European guidelines, it is important to consider that HbA1c values below 6.5% and 5.7% do not reliably exclude the presence of diabetes and prediabetes, respectively. Overall, the data argue for greater use of oral glucose tolerance tests (OGTTs) and both FPG and 2-hr glucose values for diagnosis of diabetes and prediabetes. PMID:24512556

Comparison of 24 hr total body radio-iodine retention for hypothyroid vs. thyrogen (rhTSH) stimulated whole body surveillance scan

International Nuclear Information System (INIS)

Jana, S.; Young, I.; Bukberg, P.; Luo, J.Q.; Dakhel, M.; Heiba, S.; El-Zeftawy, H.; Abdel-Dayem, H.M.

2002-01-01

Objective: Recently rhTSH has been used for WBS to avoid hypothyroid symptoms from T4/T3 withdrawal. There is limited data available in the current literature comparing total body radio-iodine clearance between hypothyroid pts and pts receiving rhTSH. Significant differences in radio-iodine clearance may influence the dose of radio-iodine required for diagnostic scanning or treatment of pts on a rhTSH protocol. Methods: To retrospectively compare the 24 hr total body I-123 retention in thyroid cancer pts who were made hypothyroid in preparation for radio-iodine scanning with the I-123 retention in pts who received thyrogen (rhTSH) but were maintained on thyroid hormone replacement. Inclusion criteria were as follows: Histologically diagnosed well diff. thyroid Ca s/p surgery and I-131 Rx in the past who were clinically disease free at the time of scanning. No abn. visible I-123 uptake on WBS and 24 hr neck uptake ≤ 1%. Tg level ≤ 2ng off T4/T3 or ≤ 2ng increase from basal level after rhTSH. Anti-Tg Ab negative. Serum Creatine ≤ 1.4 mg/dl. Serum ALT < 35, AST < 35. Total 78 pts were divided into the following 3 groups (Gp): Gp-1 (29 pts) received 2 IM inj. Of 0.9 mg rhTSH 24 and 48 hrs prior to oral dose of 10 mCi I-123. Gp-2 (30 pts) followed hypothyroid protocol i.e., off T4 ≥ 4 wks or T3 ≥ 10 days in order to achieve TSH ≥ 30 MIU/L. The dose of I-123 was 5 mCi. Gp-3 (19 pts) similar to Gp-2 i.e., hypothyroid but scanned using 10 mCi of I-123. Imaging protocol: Pts were scanned 4 hrs and 24 hrs after I-123 administration in a dual head gamma camera for 30 mins. Total body and neck counting were obtained from the geometric mean of Ant and Post images with appropriate decay correction. 24 hr total body retention (TBR) of I-123 were calculated and expressed in %, considering 100% at 4 hrs. Results: Demographic Profile of 3 Patient Groups. AST/ALT was < 35 and 24 hrs neck uptake was ≤ 1.0% all pts. Comparison of 24 hr % TBR of I-123 in 3 Patient Groups

Progression-free survival/time to progression as a potential surrogate for overall survival in HR+, HER2– metastatic breast cancer

Directory of Open Access Journals (Sweden)

Forsythe A

2018-05-01

Full Text Available Anna Forsythe,1 David Chandiwana,2 Janina Barth,3 Marroon Thabane,4 Johan Baeck,2 Gabriel Tremblay1 1Purple Squirrel Economics, New York, NY, 2Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; 3Novartis Pharma GmbH, Nuremberg, Germany; 4Novartis Pharmaceuticals Incorporated, Dorval, QC, Canada Background: Several recent randomized controlled trials (RCTs in hormone receptor-positive (HR+, human epidermal growth factor receptor 2-negative (HER2– metastatic breast cancer (MBC have demonstrated significant improvements in progression-free survival (PFS; however, few have reported improvement in overall survival (OS. The surrogacy of PFS or time to progression (TTP for OS has not been formally investigated in HR+, HER2– MBC.Methods: A systematic literature review of RCTs in HR+, HER2– MBC was conducted to identify studies that reported both median PFS/TTP and OS. The correlation between PFS/TTP and OS was evaluated using Pearson’s product–moment correlation and Spearman’s rank correlation. Subgroup analyses were performed to explore possible reasons for heterogeneity. Errors-in-variables weighted least squares regression (LSR was used to model incremental OS months as a function of incremental PFS/TTP months. An exploratory analysis investigated the impact of three covariates (chemotherapy vs hormonal/targeted therapy, PFS vs TTP, and first-line therapy vs second-line therapy or greater on OS prediction. The lower 95% prediction band was used to determine the minimum incremental PFS/TTP months required to predict OS benefit (surrogate threshold effect [STE].Results: Forty studies were identified. There was a statistically significant correlation between median PFS/TTP and OS (Pearson =0.741, P=0.000; Spearman =0.650, P=0.000. These results proved consistent for chemotherapy and hormonal/targeted therapy. Univariate LSR analysis yielded an R2 of 0.354 with 1 incremental PFS/TTP month corresponding to 1.13 incremental OS months

Electronic Properties of Curved and Defective 2-D BN Nanostructures

Science.gov (United States)

Beach, Kory; Terrones, Humberto; Raeliarijaona, Aldo; Siegel, Ross; Florio, Fred

Density functional theory (DFT) with local density approximation (LDA) pseudopotentials is used to calculate the band structure and density of states of various novel 2-D BN nanostructures. Three types of systems are studied: Schwarzites, a Haeckelite, and an h-BN monolayer. Schwarzites are negatively curved structures in which the curvature is due to the introduction of octagonal rings of alternating boron and nitrogen atoms. In particular, three families of Schwarzites are analyzed: P, G and IWP. The Haeckelites on the other hand, are flat layers composed of squares and octagons of BN. It is found that all these BN allotropes are metastable in which the band gap is direct and smaller than the most stable system, h-BN. National Science Foundation (EFRI-1433311).

The Interplay between Leadership and Team Performance: An Empirical Investigation in a Major Swiss HR Consulting Firm

Directory of Open Access Journals (Sweden)

Daniel Seelhofer

2017-04-01

Full Text Available This paper reports the results of an empirical examination of leadership traits and behaviors that contributed to team performance in a major Swiss HR consulting firm. Based on personality tests, survey research, and in-depth interviews, results indicate that, in the context of the company’s sales-driven, high-pressure environment, personality factors such as conscientiousness or detail-orientation seem to be better predictors of leadership success than extraversion and openness to experience. Female leaders overall outperformed their male counterparts, and experience was found to significantly contribute to superior performance. Implications for hiring, development, and succession practices are discussed.

Treatment results of the Tokai-POSG 8610HR pilot protocol for children with high-risk acute lymphoblastic leukemia

Energy Technology Data Exchange (ETDEWEB)

Hongo, Teruaki; Inoue, Noriko [Hamamatsu Medical Univ., Shizuoka (Japan); Horibe, Keizo [and others

1997-10-01

We reported the treatment results of Tokai-POSG 8610HR pilot protocol for children with high-risk acute lymphoblastic leukemia (ALL). From Oct. 1986 to Jan. 1991, 43 eligible children were enrolled, who had one or more following high-risk factors: age{>=}10 years old, initial white blood cell count (WBC) of 50,000/{mu}l or more, and extramedullary leukemia. All patients received induction therapy consisting of vincristine, dexamethasone, cyclophosphamide and daunorubicin, followed by central nervous system prophylaxis by 24 Gy cranial irradiation, consolidation therapy and cyclic maintenance by multidrugs for 3 years after diagnosis. Complete remission was achieved in 39 patients. The 5-year event-free survival (EFS) rate was 72.6{+-}7.1%. The only factor of an adverse association with EFS was a initial WBC of 10,000/{mu}l or more (p=0.002) in the 24 patients who were 10 years old or over. The factors related to a negative survival were male gender (p=0.031) and an initial WBC of 10,000/{mu}l or more (p=0.0012) in 43 patients. The major toxicities of the therapy were pancreatitis and allergic reaction due to{sub L}-ASP administration, and growth hormone deficiency due to cranial irradiation. Tokai 8610HR pilot protocol was a promising regimen, but further intensive chemotherapy was needed for improvement or the prognosis of the older patients with high initial WBC greater than 10,000/{mu}l. (author)

Treatment results of the Tokai-POSG 8610HR pilot protocol for children with high-risk acute lymphoblastic leukemia

International Nuclear Information System (INIS)

Hongo, Teruaki; Inoue, Noriko; Horibe, Keizo

1997-01-01

We reported the treatment results of Tokai-POSG 8610HR pilot protocol for children with high-risk acute lymphoblastic leukemia (ALL). From Oct. 1986 to Jan. 1991, 43 eligible children were enrolled, who had one or more following high-risk factors: age≥10 years old, initial white blood cell count (WBC) of 50,000/μl or more, and extramedullary leukemia. All patients received induction therapy consisting of vincristine, dexamethasone, cyclophosphamide and daunorubicin, followed by central nervous system prophylaxis by 24 Gy cranial irradiation, consolidation therapy and cyclic maintenance by multidrugs for 3 years after diagnosis. Complete remission was achieved in 39 patients. The 5-year event-free survival (EFS) rate was 72.6±7.1%. The only factor of an adverse association with EFS was a initial WBC of 10,000/μl or more (p=0.002) in the 24 patients who were 10 years old or over. The factors related to a negative survival were male gender (p=0.031) and an initial WBC of 10,000/μl or more (p=0.0012) in 43 patients. The major toxicities of the therapy were pancreatitis and allergic reaction due to L -ASP administration, and growth hormone deficiency due to cranial irradiation. Tokai 8610HR pilot protocol was a promising regimen, but further intensive chemotherapy was needed for improvement or the prognosis of the older patients with high initial WBC greater than 10,000/μl. (author)

Experimental analysis of volumetric wear behavioural and mechanical properties study of as cast and 1Hr homogenized Al-25Mg2Si2Cu4Ni alloy at constant load

Science.gov (United States)

Harlapur, M. D.; Mallapur, D. G.; Udupa, K. Rajendra

2018-04-01

In the current study, an experimental analysis of volumetric wear behaviour and mechanical properties of aluminium (Al-25Mg2Si2Cu4Ni) alloy in as cast and 1Hr homogenized with T6 heat treatment is carried out at constant load. Pin-on-disc apparatus was used to carry out sliding wear test. Mechanical properties such as tensile, hardness and compression test on as-cast and 1 hr homogenized samples are measured. Universal testing machine was used to conduct the tensile and compressive test at room temperature. Brinell hardness tester was used to conduct the hardness test. The scanning electron microscope was used to analyze the worn-out wear surfaces. Wear results and mechanical properties shows that 1Hr homogenized Al-25Mg2Si2Cu4Ni alloy samples with T6 treated had better volumetric wear resistance, hardness, tensile and compressive strength as compared to as cast samples.

HR outsourcing jako nový nástroj strategického řízení lidských zdrojů.

OpenAIRE

Nováčková, Lenka

2007-01-01

The dissertation thesis investigates the most up-to-date subject matter of contemporary business life, both internationally and locally -- Human Resources outsourcing, which appears to have become a new strategic tool for Human Resources Management. The concept means the strategically motivated external execution of some or all HR processes, which would otherwise be performed by internal staff, along with the assignment of the responsibility for those processes to external providers. Effectiv...

What Is the Future of Employer Branding Through Social Media? Results of the Delphi Study into the Perceptions of HR Professionals and Academics

NARCIS (Netherlands)

Bondarouk, Tatiana; Ruel, Hubertus Johannes Maria; Axinia, E.; Arama, R.; Bondarouk, T.V.; Olivas-Junjan, M.R.

2013-01-01

Purpose — HR professionals have identified the power of information sharing for employer branding that could be obtained through the rapid growth of social media usage. The growing interest in and power of social media seem to be important for companies that want to make themselves known as

TREATMENT TESTS FOR EX SITU REMOVAL OF CHROMATE & NITRATE & URANIUM (VI) FROM HANFORD (100-HR-3) GROUNDWATER FINAL REPORT

Energy Technology Data Exchange (ETDEWEB)

BECK MA; DUNCAN JB

1994-01-03

This report describes batch and ion exchange column laboratory scale studies investigating ex situ methods to remove chromate (chromium [VI]), nitrate (NO{sub 3}{sup -}) and uranium (present as uranium [VI]) from contaminated Hanford site groundwaters. The technologies investigated include: chemical precipitation or coprecipitation to remove chromate and uranium; and anion exchange to remove chromate, uranium and nitrate. The technologies investigated were specified in the 100-HR-3 Groundwater Treatability Test Plan. The method suggested for future study is anion exchange.

Targeted toxicological screening for acidic, neutral and basic substances in postmortem and antemortem whole blood using simple protein precipitation and UPLC-HR-TOF-MS

DEFF Research Database (Denmark)

Telving, Rasmus; Hasselstrøm, Jørgen Bo; Andreasen, Mette Findal

2016-01-01

-HR-TOF-MS was achieved in one injection. This method covered basic substances, substances traditionally analyzed in negative ESI (e.g., salicylic acid), small highly polar substances such as beta- and gamma-hydroxybutyric acid (BHB and GHB, respectively) and highly non-polar substances such as amiodarone. The new method......A broad targeted screening method based on broadband collision-induced dissociation (bbCID) ultra-performance liquid chromatography high-resolution time-of-flight mass spectrometry (UPLC-HR-TOF-MS) was developed and evaluated for toxicological screening of whole blood samples. The acidic, neutral...... was performed on spiked whole blood samples and authentic postmortem and antemortem whole blood samples. For most of the basic drugs, the established cut-off limits were very low, ranging from 0.25ng/g to 50ng/g. The established cut-off limits for most neutral and acidic drugs, were in the range from 50ng...

Urban Area Extent Extraction in Spaceborne HR and VHR Data Using Multi-Resolution Features

Directory of Open Access Journals (Sweden)

Gianni Cristian Iannelli

2014-09-01

Full Text Available Detection of urban area extents by means of remotely sensed data is a difficult task, especially because of the multiple, diverse definitions of what an “urban area” is. The models of urban areas listed in technical literature are based on the combination of spectral information with spatial patterns, possibly at different spatial resolutions. Starting from the same data set, “urban area” extraction may thus lead to multiple outputs. If this is done in a well-structured framework, however, this may be considered as an advantage rather than an issue. This paper proposes a novel framework for urban area extent extraction from multispectral Earth Observation (EO data. The key is to compute and combine spectral and multi-scale spatial features. By selecting the most adequate features, and combining them with proper logical rules, the approach allows matching multiple urban area models. Experimental results for different locations in Brazil and Kenya using High-Resolution (HR data prove the usefulness and flexibility of the framework.

Geophysical investigation of the 116-H-1 liquid waste disposal trench, 100-HR-1 operable unit

International Nuclear Information System (INIS)

Bergstrom, K.A.; Mitchell, T.H.

1996-04-01

A geophysical investigation and data integration were conducted for the 116-H-1 Liquid Waste Disposal Trench, which is located in the 100-HR-1 Operable Unit. The 116-H-1 Liquid Waste Disposal Trench is also known as the 107-H Liquid Waste Disposal Trench, the 107-H Rupture Effluent Trench, and the 107-H Trench (Deford and Einan 1995). The trench was primarily used to hold effluent from the 107-H Retention Basin that had become radioactive from contact with ruptured fuel elements. The effluent may include debris from the ruptured fuel elements (Koop 1964). The 116-H-1 Liquid Waste Disposal Trench was also used to hold water and sludge from the 107-H Retention Basin during the basin's deactivation in 1965

Data validation report for the 100-HR-3 Operable Unit first quarter 1994 groundwater sampling data

Energy Technology Data Exchange (ETDEWEB)

Biggerstaff, R.L.

1994-06-24

Westinghouse-Hanford has requested that a minimum of 20% of the total number of Sample Delivery Groups be validated for the 100-HR-3 Operable Unit First Quarter 1994 Groundwater Sampling Investigation. Therefore, the data from the chemical analysis of twenty-four samples from this sampling event and their related quality assurance samples were reviewed and validated to verify that reported sample results were of sufficient quality to support decisions regarding remedial actions performed at this site. The samples were analyzed by Thermo-Analytic Laboratories (TMA) and Roy F. Weston Laboratories (WESTON) using US Environmental Protection Agency (EPA) CLP protocols. Sample analyses included: inorganics; and general chemical parameters. Forty-two samples were validated for radiochemical parameters by TMA and Teledyne.

Data validation report for the 100-HR-3 Operable Unit first quarter 1994 groundwater sampling data

International Nuclear Information System (INIS)

Biggerstaff, R.L.

1994-01-01

Westinghouse-Hanford has requested that a minimum of 20% of the total number of Sample Delivery Groups be validated for the 100-HR-3 Operable Unit First Quarter 1994 Groundwater Sampling Investigation. Therefore, the data from the chemical analysis of twenty-four samples from this sampling event and their related quality assurance samples were reviewed and validated to verify that reported sample results were of sufficient quality to support decisions regarding remedial actions performed at this site. The samples were analyzed by Thermo-Analytic Laboratories (TMA) and Roy F. Weston Laboratories (WESTON) using US Environmental Protection Agency (EPA) CLP protocols. Sample analyses included: inorganics; and general chemical parameters. Forty-two samples were validated for radiochemical parameters by TMA and Teledyne

HR-TEM and FT-Raman dataset of the caffeine interacted Phe-Phe peptide nanotube for possible sensing applications.

Science.gov (United States)

Narayanan, A Lakshmi; Dhamodaran, M; Solomon, J Samu; Karthikeyan, B; Govindhan, R

2018-02-01

Sensing ability of caffeine interaction with Phe-Phe annotates (PNTs), is presented (Govindhan et al., 2017; Karthikeyan et al., 2014; Tavagnacco et al., 2013; Kennedy et al., 2011; Wang et al., 2017) [1-5] in this data set. Investigation of synthesized caffeine carrying peptide nanotubes are carried out by FT-Raman spectral analysis and high resolution transmission electron microscopy (HR-TEM). Particle size of the caffeine loaded PNTs is < 40 nm. The FT-Raman spectrum signals are enhanced in the region of 400-1700 cm -1 . These data are ideal tool for the applications like biosensing and drug delivery research (DDS).

Object Permanence After a 24-Hr Delay and Leaving the Locale of Disappearance: The Role of Memory, Space, and Identity

OpenAIRE

Moore, M. Keith; Meltzoff, Andrew N.

2004-01-01

Fourteen-month-old infants saw an object hidden inside a container and were removed from the disappearance locale for 24 hr. Upon their return, they searched correctly for the hidden object, demonstrating object permanence and long-term memory. Control infants who saw no disappearance did not search. In Experiment 2, infants returned to see the container either in the same or a different room. Performance by room-change infants dropped to baseline levels, suggesting that infant search for hid...

Why are women still under represented in senior jobs in SET1 in academic universities and what are the HR implications?

OpenAIRE

Howe-Walsh, Liza; Page, Samantha; Turnbull, Sarah

2012-01-01

Most universities have put the necessary systems in place to ensure gender equality within the workplace. Many have established HR policies and procedures to ensure women have an equal chance as men to access senior posts. Some universities implement gender equality policies to support commitment to institutional equality and diversity strategies. Such strategies outline frameworks, which universities will use to promote gender equality including obligations under the Gender Equality Act.

Final hazard classification for the 100-HR-3 and 100-KR-4 pump-and-treat systems

International Nuclear Information System (INIS)

Oestreich, D.K.

1996-09-01

The purpose of this hazard classification report is to document the final hazard classification for two treatment facilities that will be located in the 100-HR-3 and 100-KR-4 Operable Units. These facilities will be sited at the 100-H and 100-K Areas for removal of chromium VI from the groundwater. The FHC is based on the hazardous material inventory (both chromium and radionuclides) that accumulates on the anion-exchange resin up to the point of resin saturation. Segmentation of the total inventory can be readily justified because the inventory resides in a number of separate resin vessels, and it is unreasonable to consider that a release could take place from more than one vessel at a time as a result of common-cause failure

A ∼ 3.8 hr PERIODICITY FROM AN ULTRASOFT ACTIVE GALACTIC NUCLEUS CANDIDATE

Energy Technology Data Exchange (ETDEWEB)

Lin, Dacheng; Irwin, Jimmy A. [Department of Physics and Astronomy, University of Alabama, Box 870324, Tuscaloosa, AL 35487 (United States); Godet, Olivier; Webb, Natalie A.; Barret, Didier, E-mail: dlin@ua.edu [CNRS, IRAP, 9 avenue du Colonel Roche, BP 44346, F-31028 Toulouse Cedex 4 (France)

2013-10-10

Very few galactic nuclei are found to show significant X-ray quasi-periodic oscillations (QPOs). After carefully modeling the noise continuum, we find that the ∼3.8 hr QPO in the ultrasoft active galactic nucleus candidate 2XMM J123103.2+110648 was significantly detected (∼5σ) in two XMM-Newton observations in 2005, but not in the one in 2003. The QPO root mean square (rms) is very high and increases from ∼25% in 0.2-0.5 keV to ∼50% in 1-2 keV. The QPO probably corresponds to the low-frequency type in Galactic black hole X-ray binaries, considering its large rms and the probably low mass (∼10{sup 5} M {sub ☉}) of the black hole in the nucleus. We also fit the soft X-ray spectra from the three XMM-Newton observations and find that they can be described with either pure thermal disk emission or optically thick low-temperature Comptonization. We see no clear X-ray emission from the two Swift observations in 2013, indicating lower source fluxes than those in XMM-Newton observations.

Analysis of performance measurement at HR-GR Department using the balance scorecard method

Science.gov (United States)

Vienni; Bachtiar, M.

2017-12-01

PT. X is a company engaged in logistics service in Indonesia. Every company will certainly face a dynamic business environment. Competitors not only from domestic but also from overseas. To be successful in achieving its objectives, company should have a comprehensive measurement system as a strategy feedback that will drive the performance of company. HR-GA department is department that coordinate directly with company’s management. Company through departments expect development goals in individual and also support of infrastructure will run smoothly. In 2015, company has taken steps to conduct a balanced scorecard as performance measurement. Nevertheless, a number of factors so it cannot run optimally. This study aims to analyse the current system and provided suggestions in order to give an overview to department related to its current performance. The results of data processing show that there are 8 objective strategies that have been formulated with 9 key performance indicators. Based on the results of scorecard, obtained values of 4.44 for customer perspective, 4.32 for internal business process perspective & 5.00 for learning and growth perspective. It concludes that performance based on perspectives are categorized very well

Information from the HR Department for members of the personnel residing in FRANCE

CERN Document Server

HR Department

2007-01-01

Tax assessment notice sent by the French Tax Centre Members of the personnel residing in France have received (or are about to receive) a document issued by their local Centre des Impôts (CDI) entitled «Avis d’impôt – IMPÔT SUR LES REVENUS DE 2006». The document states in particular that: «La déclaration que vous avez déposée ne comporte aucun revenu pour l’année 2006. Je vous informe que le présent avis ne constitue pas un justificatif d’absence de tout revenu. Vous avez perçu des revenus en provenance d’organismes internationaux, de missions diplomatiques ou consulaires exonérés d’impôt en France. Indiquez-les au bas de cet avis» [1] This document must not be returned to your CDI. However, you must keep it as the French authorities may ask you to produce it as evidence of your tax position in France. Further information may be obtained directly from your CDI. HR DepartmentTel: 73903 [1] CERN translation, for information only: "The declaration...

Crystallization and preliminary X-ray diffraction studies of the ubiquitin-like (UbL) domain of the human homologue A of Rad23 (hHR23A) protein.

Science.gov (United States)

Chen, Yu Wai; Tajima, Toshitaka; Rees, Martin; Garcia-Maya, Mitla

2009-09-01

Human homologue A of Rad23 (hHR23A) plays dual roles in DNA repair as well as serving as a shuttle vehicle targeting polyubiquitinated proteins for degradation. Its N-terminal ubiquitin-like (UbL) domain interacts with the 19S proteasomal cap and provides the docking mechanism for protein delivery. Pyramidal crystals of the UbL domain of hHR23A were obtained by the hanging-drop vapour-diffusion method with ammonium sulfate as the crystallizing agent. The crystals diffracted to beyond 2 A resolution and belonged to the hexagonal space group P6(5)22, with unit-cell parameters a = b = 78.48, c = 63.57 A. The structure was solved by molecular replacement using the UbL domain of yeast Dsk2 as the search model.

Development of methodologies used in the areas of safeguards and nuclear forensics based on LA-HR-ICP-MS technique

International Nuclear Information System (INIS)

Marin, Rafael Coelho

2013-01-01

Environmental sampling performed by means of swipe samples is a methodology frequently employed by International Atomic Energy Agency (IAEA) to verify if the signatory States of the Safeguards Agreements are conducing unauthorized activities. Swipe samples analysis is complementary to the Safeguards ordinary procedures used to verify the information given by the States. In this work it was described a methodology intending to strengthen the nuclear safeguards and nuclear forensics procedures. The proposal is to study and evaluate the laser ablation high resolution inductively coupled plasma mass spectrometry (LA-HR-ICP-MS) technique as an alternative to analyze the real-life swipe samples. The precision achieved through the standard (CRM - 125A) measurements, represented by the relative standard deviation (RSD), was respectively 1.3 %, 0.2 % e 7.6 % for the 234 U/ 238 U, 235 U/ 238 U e 236 U/ 238 U isotopes ratios. The percent uncertainties (u %), which covers the RSD, ranged from 3.5 % to 29.8 % to the 235 U/ 238 U measurements and from 16.6 % to 42.9 % to the 234 U/ 238 U isotope ratio. These results were compatible with former studies performed by the LA-HR-ICP-MS that analyzed real-life swipe samples collected at a nuclear facility. Swipe samples collected from several points of the nuclear facility presented enrichment level ranging from (2.3 ± 0.7) % (sample 3) to (17.3 ± 2.8) % (sample 18). They also allowed detecting different enrichment levels within the facility. (author)

Nuclear planetology: understanding habitable planets as Galactic bulge stellar remnants (black dwarfs) in a Hertzsprung-Russell (HR) diagram

Science.gov (United States)

Roller, Goetz

2016-04-01

The Hertzsprung-Russell (HR) diagram is one of the most important diagrams in astronomy. In a HR diagram, the luminosity of stars and/or stellar remnants (white dwarf stars, WD's), relative to the luminosity of the sun, is plotted versus their surface temperatures (Teff). The Earth shows a striking similarity in size (radius ≈ 6.370 km) and Teff of its outer core surface (Teff ≈ 3800 K at the core-mantle-boundary) with old WD's (radius ≈ 6.300 km) like WD0346+246 (Teff ≈ 3820 K after ≈ 12.7 Ga [1]), which plot in the HR diagram close to the low-mass extension of the stellar population or main sequence. In the light of nuclear planetology [2], Earth-like planets are regarded as old, down-cooled and differentiated black dwarfs (Fe-C BLD's) after massive decompression, the most important nuclear reactions involved being 56Fe(γ,α)52Cr (etc.), possibly responsible for extreme terrestrial glaciations events ("snowball" Earth), together with (γ,n), (γ,p) and fusion reactions like 12C(α,γ)16O. The latter reaction might have caused oxidation of the planet from inside out. Nuclear planetology is a new research field, tightly constrained by a coupled 187Re-232Th-238U systematics. By means of nuclear/quantum physics and taking the theory of relativity into account, it aims at understanding the thermal and chemical evolution of Fe-C BLD's after gravitational contraction (e.g. Mercury) or Fermi-pressure controlled collapse (e.g. Earth) events after massive decompression, leading possibly to an r-process event, towards the end of their cooling period [2]. So far and based upon 187Re-232Th-238U nuclear geochronometry, the Fe-C BLD hypothesis can successfully explain the global terrestrial MORB 232Th/238U signature [3]. Thus, it may help to elucidate the DM (depleted mantle), EMI (enriched mantle 1), EMII (enriched mantle 2) or HIMU (high U/Pb) reservoirs, and the 187Os/188Os isotopic dichotomy in Archean magmatic rocks and sediments [4]. Here I present a conceptual

Mitigation action plan for the 100-KR-4, 100-HR-3 pump and treat

International Nuclear Information System (INIS)

Weiss, S.G.

1996-10-01

This project involves drilling 22 wells, improving access roads to existing new wells, laying connecting pipes, and constructing groundwater treatment facilities in the 100-KR-4 and 100-HR-3 Operable Units. These facilities are located at the Hanford Site in Richland, Washington. The drilling is expected to be completed by October 1996, but the treatment operations will continue for approximately 10 years. Thirteen of the new wells are to be placed in the 100-K Area, five in the 100-H Area, and four in the 100-D Area. A 4 km (2.5 mi) pipeline will run from the wells at the 100-D Area to the treatment facility at the 100-H Area. The 116-K-2 Trench received reactor effluents from 1955 to 1971. It is 1,460 m long by 16.4 m wide by 5.5 m deep with spoil pits at the surface on both sides. Washouts occurred during operation, causing several surface contamination areas between the trench and river that were covered with a few feet of soil

Ascertaining serum levels of trace elements in melanoma patients using PIXE and HR-ICPMS

Science.gov (United States)

Bernardes, S.; Tabacniks, M. H.; Santos, I. D. A. O.; Oliveira, A. F.; Shie, J. N.; Sarkis, J. E. S.; Oliveira, T.

2014-01-01

Melanoma is a serious and deadly form of skin cancer. However, patients' chances of survival and recovery are considerably increased when it is diagnosed and treated in its early stages. In this study, trace element concentrations in serum samples from patients with melanoma were measured using PIXE (Proton Induced X-ray Emission) and HR-ICPMS (High-Resolution Inductively Coupled Plasma Mass Spectrometry), with the purpose of correlating these concentrations with the disease. Blood samples from 30 melanoma patients and 116 healthy donors were collected at São Paulo Hospital (protocol CEP 1036/08 UNIFESP). Relevant clinical information on the patients has also been included in the statistical analysis. Analysis of the control group showed different P and Mg concentrations in individuals above and below 40 years of age. P, S, Ca, Cu and Zn concentrations in healthy individuals differed according to gender, highlighting the necessity to include age and gender variables in the case-control analysis. There were also differences in K, S, Ca and Se concentrations between the control and melanoma groups.

Ascertaining serum levels of trace elements in melanoma patients using PIXE and HR-ICPMS

Energy Technology Data Exchange (ETDEWEB)

Bernardes, S., E-mail: suene@if.usp.br [Physics Institute, University of São Paulo (Brazil); Tabacniks, M.H. [Physics Institute, University of São Paulo (Brazil); Santos, I.D.A.O.; Oliveira, A.F.; Shie, J.N. [São Paulo Federal University (UNIFESP), São Paulo (Brazil); Sarkis, J.E.S.; Oliveira, T. [Institute of Energy and Nuclear Research (IPEN), Laboratory of Chemical Characterization (LCQ), Center for Chemistry and the Environment - CQMA, Sao Paulo (Brazil)

2014-01-01

Melanoma is a serious and deadly form of skin cancer. However, patients’ chances of survival and recovery are considerably increased when it is diagnosed and treated in its early stages. In this study, trace element concentrations in serum samples from patients with melanoma were measured using PIXE (Proton Induced X-ray Emission) and HR-ICPMS (High-Resolution Inductively Coupled Plasma Mass Spectrometry), with the purpose of correlating these concentrations with the disease. Blood samples from 30 melanoma patients and 116 healthy donors were collected at São Paulo Hospital (protocol CEP 1036/08 UNIFESP). Relevant clinical information on the patients has also been included in the statistical analysis. Analysis of the control group showed different P and Mg concentrations in individuals above and below 40 years of age. P, S, Ca, Cu and Zn concentrations in healthy individuals differed according to gender, highlighting the necessity to include age and gender variables in the case-control analysis. There were also differences in K, S, Ca and Se concentrations between the control and melanoma groups.

RECONNAISSANCE OF THE HR 8799 EXOSOLAR SYSTEM. I. NEAR-INFRARED SPECTROSCOPY

Energy Technology Data Exchange (ETDEWEB)

Oppenheimer, B. R.; Beichman, C.; Brenner, D.; Nilsson, R.; Parry, I. R.; Rice, E. [Astrophysics Department, American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024 (United States); Baranec, C.; Dekany, R.; Hale, D. [Caltech Optical Observatories, California Institute of Technology, Pasadena, CA 91125 (United States); Burruss, R.; Cady, E.; Ligon, E. R.; Lockhart, T. [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Dr., Pasadena CA 91109 (United States); Crepp, J. R.; Hillenbrand, L.; Hinkley, S. [Department of Astronomy, California Institute of Technology, 1200 E. California Blvd, MC 249-17, Pasadena, CA 91125 (United States); Fergus, R. [Department of Computer Science, Courant Institute of Mathematical Sciences, New York University, 715 Broadway, New York, NY 10003 (United States); Hogg, David W. [Center for Cosmology and Particle Physics, Department of Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); King, D. [Institute of Astronomy, Cambridge University, Madingley Road, Cambridge CB3 0HA (United Kingdom); Pueyo, L., E-mail: bro@amnh.org [Department of Physics and Astronomy, The Johns Hopkins University, Baltimore, MD 21218 (United States); and others

2013-05-01

We obtained spectra in the wavelength range {lambda} = 995-1769 nm of all four known planets orbiting the star HR 8799. Using the suite of instrumentation known as Project 1640 on the Palomar 5 m Hale Telescope, we acquired data at two epochs. This allowed for multiple imaging detections of the companions and multiple extractions of low-resolution (R {approx} 35) spectra. Data reduction employed two different methods of speckle suppression and spectrum extraction, both yielding results that agree. The spectra do not directly correspond to those of any known objects, although similarities with L and T dwarfs are present, as well as some characteristics similar to planets such as Saturn. We tentatively identify the presence of CH{sub 4} along with NH{sub 3} and/or C{sub 2}H{sub 2}, and possibly CO{sub 2} or HCN in varying amounts in each component of the system. Other studies suggested red colors for these faint companions, and our data confirm those observations. Cloudy models, based on previous photometric observations, may provide the best explanation for the new data presented here. Notable in our data is that these presumably co-eval objects of similar luminosity have significantly different spectra; the diversity of planets may be greater than previously thought. The techniques and methods employed in this paper represent a new capability to observe and rapidly characterize exoplanetary systems in a routine manner over a broad range of planet masses and separations. These are the first simultaneous spectroscopic observations of multiple planets in a planetary system other than our own.

RESHAPING ORGANIZATIONS – MANAGING PEOPLE THROUGH HR STRATEGIES AND INTERNAL MARKETING

Directory of Open Access Journals (Sweden)

Roxana Cioclov

2014-10-01

Full Text Available The following paper aims at presenting key concepts in regard to the interconnectivity between two similar and frequently confused practices – Human Resource Management and Internal Marketing. Therefore, it is intend to present both fields distinctively, in order to emphasise in the end the added value of the two working together. Given the fact that, in the specialised literature, there are different approaches on this subject and many questions raised regarding the separation of the instruments and particular objectives of the two practices, the paper presents a simplified approach on the HRM Cycle in comparison with the IM Cycle. Therefore, the paper is structured as follows: (1 HRM’s impact on the general activity of an organization – whether it is a manufacturing company or a service provider; (2 IM’s impact on the internal and external environment of the organization; (3 Analysis on the connection and in-/inter-/dependency of the two concepts and their meaning. Although HRM seems to bring numerous advantages to the organization, the current paper states that HR cannot be done at the same efficiency level in the absence of good Internal Marketing practices that allow the word - of - mouth to spread between the present and possible future employees. It is about a good branding that has to exceed the company’s geographical boundaries and to create the need, not only in terms of product consumer’s behavior, but also in regard to employees that want to be part of the brand.

Elemental abundance analyses with DAO spectrograms: XXXII. HR 6455 (A3 III), δ Aqr (A3 V), η Lep (F2 V), and 1 Boo (A1 V)

Science.gov (United States)

Yüce, K.; Adelman, S. J.; Gulliver, A. F.; Hill, G.

2011-08-01

We examine the sharp-lined stars HR 6455 (A3 III, v sin i = 8.7 km s-1) and η Lep (F2 V, v sin i = 13.5 km s-1) as well as δ Aqr (A3 V, v sin i = 81 km s-1) and 1 Boo (A1 V, v sin i = 59 km s-1) to increase the number consistently analyzed A and F stars using high dispersion and high S/N (≥200) spectrograms obtained with CCD detectors at the long Coudé camera of the 1.22-m telescope of the Dominion Astrophysical Observatory. Such studies contribute to understanding systematic abundance differences between normal and non-magnetic main-sequence band chemically peculiar A and early F stars. LTE fine analyses of HR 6455, δ Aqr, and 1 Boo using Kurucz's ATLAS suite programs show the same general elemental abundance trends with differences in the metal richness. Light and iron-peak element abundances are generally solar or overabundant while heavy element and rare earth element abundances are overabundant. HR 6455 is an evolved Am star while δ Aqr and 1 Boo show the phenomenon to different extents. Most derived abundances of η Lep are solar. Table 3 is available at the CDS via http://cdsarc.u-strasbg.fr/cgi-bin/qcat?J/AN/332/681

Indian women with higher serum concentrations of folate and vitamin B12 are significantly less likely to be infected with carcinogenic or high-risk (HR types of human papillomaviruses (HPVs

Directory of Open Access Journals (Sweden)

Chandrika J Piyathilake

2010-01-01

Full Text Available Chandrika J Piyathilake1, Suguna Badiga1, Proma Paul2, Vijayaraghavan K3, Haripriya Vedantham3, Mrudula Sudula3, Pavani Sowjanya3, Gayatri Ramakrishna4, Keerti V Shah5, Edward E Partridge6, Patti E Gravitt21Department of Nutrition Sciences, The University of Alabama at Birmingham (UAB, Birmingham, AL, USA; 2Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; 3SHARE INDIA, Mediciti Institute of Medical Sciences, Ghanpur, India; 4Center for DNA Fingerprinting and Diagnostics, Hyderabad, India; 5Department of Molecular biology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD USA; 6UAB Comprehensive Cancer Center, The University of Alabama Birmingham (UAB, Birmingham, AL, USABackground: Studies conducted in the USA have demonstrated that micronutrients such as folate and vitamin B12 play a significant role in modifying the natural history of high-risk human papillomaviruses (HR-HPVs, the causative agent for developing invasive cervical cancer (CC and its precursor lesions.Objective: The purpose of the current study was to investigate whether these micronutrients have similar effects on HR-HPV infections in Indian women.Methods: The associations between serum concentrations of folate and vitamin B12 and HR-HPV infections were evaluated in 724 women who participated in a CC screening study in the southern state of Andhra Pradesh, India. Serum folate and vitamin B12 concentrations were measured by using a competitive radio-binding assay. Digene hybrid capture 2 (HC2 assay results were used to categorize women into two groups, positive or negative for HR-HPVs. Unconditional logistic regression models specified a binary indicator of HC2 (positive/negative as the dependent variable and serum folate concentrations combined with serum vitamin B12 concentrations as the independent predictor of primary interest. Models were fitted, adjusting for age, education, marital status, parity

Anthocyanins and antioxidant capacities of six Chilean berries by HPLC-HR-ESI-ToF-MS.

Science.gov (United States)

Ramirez, Javier E; Zambrano, Ricardo; Sepúlveda, Beatriz; Kennelly, Edward J; Simirgiotis, Mario J

2015-06-01

The HPLC profiles of six fruits endemic of the VIII region of Chile were investigated using high resolution mass analysis (HR-ToF-ESI-MS). The anthocyanin fingerprints generated for the fruits were compared and the antioxidant capacities measured by the scavenging of the DPPH radical, the ferric reducing antioxidant power (FRAP), the superoxide anion scavenging activity assay (SA), and correlated with the inhibition of lipid peroxidation in human erythrocytes (LP) and total content of phenolics, flavonoids and anthocyanins measured by spectroscopic methods. Several anthocyanins were identified, including 3-O-glycosides derivatives of delphinidin, cyanidin, petunidin, peonidin and malvidin. Three phenolic acids (feruloyl-quinic acid, chlorogenic acid, and neochlorogenic acid) and five flavonols (hyperoside, isoquercitrin, quercetin, rutin, myricetin and isorhamnetin) were also identified. Calafate fruits showed the highest antioxidant activity. However, the highest LP activity was found for Chilean blueberries (>95%) followed by calafate fruits (91.27%) and luma (83.4%). Copyright © 2014 Elsevier Ltd. All rights reserved.

Topical W-7 inhibits ultraviolet radiation-induced melanogenesis in Skh:HR2 pigmented hairless mice

International Nuclear Information System (INIS)

Dowdy, J.C.; Anthony, F.A.; Costlow, M.E.

1995-01-01

We studied the effect of N-(6-aminohexyl)-5-chloro-1-napthalenesulfonamide (W-7) on ultraviolet radiation (UVR)-induced melanogenesis (tanning) in Skh:HR2 pigmented hairless mice. Topically pretreated mice were exposed to subminimal edematogenic as well as edematogenic UVR doses to establish whether W-7-UVR-induced edema prophylaxis allows increased melanogenesis while preventing edema. Ultraviolet light-irradiated vehicle control animals developed visible trans; however, both W-7-treated groups failed to tan. Topical W-7 before UVR exposure inhibited UVR induction of dopa oxidase activity in melanocytes by 49% (P=0.029) and inhibited UVR-induced deposition of melanin in the epidermis by 88% (P=0.006). Topical W-7 blocked 23% of the UVR but this blockage could not account for the inhibition of dopa oxidase and melanization. We conclude that, in addition to preventing edema, W-7 inhibits UVR-induced melanogenesis, possibly by affecting Ca 2+ -calmodulin and/or protein kinase C-dependent processes. (au) 30 refs

Topical W-7 inhibits ultraviolet radiation-induced melanogenesis in Skh:HR2 pigmented hairless mice

Energy Technology Data Exchange (ETDEWEB)

Dowdy, J.C. [Univ. of Memphis, Div. of Molecular Sciences and Microbiology, Memphis, Tennessee (United States); Anthony, F.A.; Costlow, M.E. [Schering-Plough HealthCare Products, Inc., Advanced Product Research, Memphis, Tennessee (United States)

1995-08-01

We studied the effect of N-(6-aminohexyl)-5-chloro-1-napthalenesulfonamide (W-7) on ultraviolet radiation (UVR)-induced melanogenesis (tanning) in Skh:HR2 pigmented hairless mice. Topically pretreated mice were exposed to subminimal edematogenic as well as edematogenic UVR doses to establish whether W-7-UVR-induced edema prophylaxis allows increased melanogenesis while preventing edema. Ultraviolet light-irradiated vehicle control animals developed visible trans; however, both W-7-treated groups failed to tan. Topical W-7 before UVR exposure inhibited UVR induction of dopa oxidase activity in melanocytes by 49% (P=0.029) and inhibited UVR-induced deposition of melanin in the epidermis by 88% (P=0.006). Topical W-7 blocked 23% of the UVR but this blockage could not account for the inhibition of dopa oxidase and melanization. We conclude that, in addition to preventing edema, W-7 inhibits UVR-induced melanogenesis, possibly by affecting Ca{sup 2+}-calmodulin and/or protein kinase C-dependent processes. (au) 30 refs.

Assessing Heterogeneity of Osteolytic Lesions in Multiple Myeloma by 1H HR-MAS NMR Metabolomics

Directory of Open Access Journals (Sweden)

Laurette Tavel

2016-10-01

Full Text Available Multiple myeloma (MM is a malignancy of plasma cells characterized by multifocal osteolytic bone lesions. Macroscopic and genetic heterogeneity has been documented within MM lesions. Understanding the bases of such heterogeneity may unveil relevant features of MM pathobiology. To this aim, we deployed unbiased 1H high-resolution magic-angle spinning (HR-MAS nuclear magnetic resonance (NMR metabolomics to analyze multiple biopsy specimens of osteolytic lesions from one case of pathological fracture caused by MM. Multivariate analyses on normalized metabolite peak integrals allowed clusterization of samples in accordance with a posteriori histological findings. We investigated the relationship between morphological and NMR features by merging morphological data and metabolite profiling into a single correlation matrix. Data-merging addressed tissue heterogeneity, and greatly facilitated the mapping of lesions and nearby healthy tissues. Our proof-of-principle study reveals integrated metabolomics and histomorphology as a promising approach for the targeted study of osteolytic lesions.

HR-EELS study of hydrogen bonding configuration, chemical and thermal stability of detonation nanodiamond films

Energy Technology Data Exchange (ETDEWEB)

Michaelson, Sh.; Akhvlediani, R. [Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 32000 (Israel); Petit, T.; Girard, H.A.; Arnault, J.C. [CEA, LIST, Diamond Sensors Laboratory, F-91191 Gif sur Yvette (France); Hoffman, A., E-mail: choffman@tx.technion.ac.il [Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 32000 (Israel)

2014-06-01

Nano-diamond films composed of 3–10 nm grains prepared by the detonation method and deposited onto silicon substrates by drop-casting were examined by high resolution electron energy loss spectroscopy (HR-EELS), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM) and secondary ion mass spectroscopy (SIMS). The impact of (i) ex-situ ambient annealing at 400 °C and (ii) ex-situ hydrogenation on hydrogen bonding and its thermal stability were examined. In order to clarify the changes in hydrogen bonding configuration detected on the different surfaces as a function of thermal annealing, in-situ hydrogenation by thermally activated atomic hydrogen was performed and examined. This study provides direct evidence that the exposure to ambient conditions and medium temperature ambient annealing have a pronounced effect on the hydrogen-carbon bonding configuration onto the nano-diamond surfaces. In-situ 1000 °C annealing results in irreversible changes of the film surface and partial nano-diamond silicidation.

Wear behavioral study of as cast and 7 hr homogenized Al25Mg2Si2Cu4Ni alloy at constant load

Science.gov (United States)

Harlapur, M. D.; Sondur, D. G.; Akkimardi, V. G.; Mallapur, D. G.

2018-04-01

In the current study, the wear behavior of as cast and 7 hr homogenized Al25Mg2Si2Cu4Ni alloy has been investigated. Microstructure, SEM and EDS results confirm the presence of different intermetallic and their effects on wear properties of Al25Mg2Si2Cu4Ni alloy in as cast as well as aged condition. Alloying main elements like Si, Cu, Mg and Ni partly dissolve in the primary α-Al matrix and to some amount present in the form of intermetallic phases. SEM structure of as cast alloy shows blocks of Mg2Si which is at random distributed in the aluminium matrix. Precipitates of Al2Cu in the form of Chinese script are also observed. Also `Q' phase (Al-Si-Cu-Mg) be distributed uniformly into the aluminium matrix. Few coarsened platelets of Ni are seen. In case of 7 hr homogenized samples blocks of Mg2Si get rounded at the corners, Platelets of Ni get fragmented and distributed uniformly in the aluminium matrix. Results show improved volumetric wear resistance and reduced coefficient of friction after homogenizing heat treatment.

On-line electrochemistry-bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors.

Science.gov (United States)

Falck, David; de Vlieger, Jon S B; Giera, Martin; Honing, Maarten; Irth, Hubertus; Niessen, Wilfried M A; Kool, Jeroen

2012-04-01

In this study, an integrated approach is developed for the formation, identification and biological characterization of electrochemical conversion products of p38α mitogen-activated protein kinase inhibitors. This work demonstrates the hyphenation of an electrochemical reaction cell with a continuous-flow bioaffinity assay and parallel LC-HR-MS. Competition of the formed products with a tracer (SKF-86002) that shows fluorescence enhancement in the orthosteric binding site of the p38α kinase is the readout for bioaffinity. Parallel HR-MS(n) experiments provided information on the identity of binders and non-binders. Finally, the data produced with this on-line system were compared to electrochemical conversion products generated off-line. The electrochemical conversion of 1-{6-chloro-5-[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazine-1-carbonyl]-3aH-indol-3-yl}-2-morpholinoethane-1,2-dione resulted in eight products, three of which showed bioaffinity in the continuous-flow p38α bioaffinity assay used. Electrochemical conversion of BIRB796 resulted, amongst others, in the formation of the reactive quinoneimine structure and its corresponding hydroquinone. Both products were detected in the p38α bioaffinity assay, which indicates binding to the p38α kinase.

Are coronae of late type stars made of solar-like structures? The Fx-HR diagram and the pressure-temperature correlation

OpenAIRE

Peres, G.; Orlando, S.; Reale, F.

2004-01-01

We show that stellar coronae can be composed of X-ray emitting structures like those in the solar corona, using a large set of ROSAT/PSPC observations of late-type-stars, and a large set of solar X-ray data collected with Yohkoh/SXT. We have considered data on the solar corona at various phases of the cycle and various kinds of X-ray coronal structures, from flares to the background corona. The surface flux (F_x) vs. spectral hardness ratio (HR) diagram is a fundamental tool for our study. We...

Use of Re-188 labelled anti-EGFr humanized monoclonal antibody h-R3 for radioimmunotherapy of gliomas

International Nuclear Information System (INIS)

Perera, A.; Torres, L.A.; Lopez, G.; Casaco, A.; Batista, J.F.; Pena, Y.; Coca, M.A.; Leyva, R.; Garcia, I.

2007-01-01

Full text: Locally administered monoclonal antibodies labelled with radioisotopes like 90Y, 131I, 186Re, 212Bi, 211At, 177Lu and others, constitute a viable and promising alternative for management different kind of malignancies. The development of 188W/188Re generator has given the possibility of having a radionuclide showing satisfactory features for radioimmunotherapy (Eb2.12 MeV, Eg155 keV, T1/2=16.9 h and easy to make labelling approaches, similar to used for 99mTc). Neuroepithelial-derived tumours show an increased expression of the EGF receptor with regard to adjacent normal tissue. This overexpression could be related with the autocrine stimulation of the neoplasm by EGF and TGFb. Humanized monoclonal antibody h-R3 has shown a high affinity for this EGF receptor, blocking the binding of EGF to it receptor and inducing apoptosis. Thus, it could be a good candidate for radioimmunotherapy of neuroepithelial malignancies. The aim of the present work was to label monoclonal antibody h-R3 with 188Re, to assess it in an animal model and evaluate its internal dosimetry and toxicity in patients with grade III-IV gliomas through a phase I clinical trial. Schwarz's direct labelling method was employed. Briefly, a 2000-fold molar excess of 2-mercaptoethanol was used to reduce bisulfide bonds of the antibody. The amount of sodium glucoheptonate, ascorbic acid and stannous fluoride were varied to achieve optimum labelling yield. 188Re-labeling yield was proportional to the volume of stannous glucoheptonate solution added to the formulation. Radiochemical purity of 188Re-h-R3 was 98.0±0.4%. Challenge against 300-fold molar excess of L-cysteine was made to assess the stability of the tracer. There was no significant difference between stability of 188Re-h-R3 and 99mTc-h-R3 against cysteine challenge up to 24 h. Animal biodistribution study was performed at 3 and 24 h after intravenous administration of 188Re-h-R3 through tale vein of Male Wistar rats. The results were

On the co-existence of chemically peculiar Bp stars, slowly pulsating B stars and constant B stars in the same part of the HR diagram

NARCIS (Netherlands)

Briquet, M.; Hubrig, S.; Cat, P. de; Aerts, C.C.; North, P.; Schöller, M.

2007-01-01

Aims. In order to better model massive B-type stars, we need to understand the physical processes taking place in slowly pulsating B (SPB) stars, chemically peculiar Bp stars, and non-pulsating normal B stars co-existing in the same part of the H-R diagram. Methods: We carry out a comparative study

Comparative study of a novel application of automated HR HPV assay and stability in a previously untested Preservative media

Directory of Open Access Journals (Sweden)

Mike E. Morel

2017-12-01

Full Text Available Background: The suitability and stability of cervical cells in Novaprep media (NHQ for certain HPV assays is unknown. Methods: We evaluated the accuracy of an automated HPV assay (Abbott RealTime HR HPV for cervical cells prepared in NHQ and NHQ with a pre-treatment to mimic a worst case clinical use, compared to the assay manufacturers media; repeatability and reproducibility of HPV results and the stability of detectable HPV in NHQ over time compared to CE marked liquid based cytology preservatives. Cell lines were used to simulate patient samples. Results: Cells stored in NHQ produced accurate, repeatable and reproducible results. Stability in NHQ was comparable to the best performing LBC, with at least 7 months’ stability at 18–25 °C, 2–8 °C, −20 °C and −80 °C; and at least 3 months’ stability at 40 °C. Similar results were obtained for pre-treated NHQ except only 3.5 months’ stability at 18–25 °C. Cell line samples in all media and concentrations tested were detected appropriately by the assay. Conclusions: Based on this first stage validation analytical study, cervical cells stored in NHQ are suitable for the Realtime HPV assay. There should be no reservations for inclusion of NHQ in any further validation and clinical performance evaluation of this assay. Keywords: HPV, Preservative, Sample stability, Automated HR HPV assay

Metabolism of the synthetic cannabinoids AMB-CHMICA and 5C-AKB48 in pooled human hepatocytes and rat hepatocytes analyzed by UHPLC-(IMS)-HR-MSE.

Science.gov (United States)

Mardal, Marie; Dalsgaard, Petur Weihe; Qi, Bing; Mollerup, Christian Brinch; Annaert, Pieter; Linnet, Kristian

2018-04-15

The main analytical targets of synthetic cannabinoids are often metabolites. With the high number of new psychoactive substances entering the market, suitable workflows are needed for analytical target identification in biological samples. The aims of this study were to identify the main metabolites of the synthetic cannabinoids, AMB-CHMICA and 5C-AKB48, using an in silico-assisted workflow with analytical data acquired using ultra-high-performance liquid chromatography-(ion mobility spectroscopy)-high resolution-mass spectrometry in data-independent acquisition mode (UHPLC-(IMS)-HR-MS E ). The metabolites were identified after incubation with rat and pooled human hepatocytes using UHPLC-HR-MS E , followed by UHPLC-IMS-HR-MS E . Metabolites of AMB-CHMICA and 5C-AKB48 were predicted with Meteor (Lhasa Ltd) and imported to the UNIFI software (Waters). The predicted metabolites were assigned to analytical components supported by the UNIFI in silico fragmentation tool. The main metabolic pathway of AMB-CHMICA was O-demethylation and hydroxylation of the methylhexyl moiety. For 5C-AKB48, the main metabolic pathways were hydroxylation(s) of the adamantyl moiety and oxidative dechlorination with subsequent oxidation to the ω-COOH. The matrix components in the metabolite spectra were reduced with IMS, which improved the accuracy of the spectral interpretation; however, this left fewer fragment ions for assigning sites of metabolism. Meteor was able to predict the majority of the metabolites, with the most notable exception being the oxidative dechlorination and, consequently, all metabolites that underwent that transformation pathway. Oxidative dechlorination of ω-chloroalkanes in humans has not been previously reported in the literature. The postulated metabolites can be used for screening of biological samples, with four-dimensional identification based on retention time, collision cross section, precursor ion, and fragment ions. Copyright © 2018 Elsevier B.V. All

Quantification of plasmid DNA reference materials for Shiga toxin-producing Escherichia coli based on UV, HR-ICP-MS and digital PCR.

Science.gov (United States)

Liang, Wen; Xu, Li; Sui, Zhiwei; Li, Yan; Li, Lanying; Wen, Yanli; Li, Chunhua; Ren, Shuzhen; Liu, Gang

2016-01-01

The accuracy and metrology traceability of DNA quantification is becoming a critical theme in many fields, including diagnosis, forensic analysis, microorganism detection etc. Thus the research of DNA reference materials (RMs) and consistency of DNA quantification methods has attracted considerable research interest. In this work, we developed 3 plasmid candidate RMs, containing 3 target genes of Escherichia coli O157:H7 (E. coli O157:H7) and other Shiga toxin-producing Escherichia coli (STEC): stx1, stx2, and fliC (h7) respectively. Comprehensive investigation of the plasmid RMs was performed for their sequence, purity, homogeneity and stability, and then the concentration was quantified by three different methods: ultraviolet spectrophotometer (UV), high resolution inductively coupled plasma mass spectrometry (HR-ICP-MS) and digital PCR. As a routinely applied method for DNA analysis, UV was utilized for the quantification (OD260) and purity analysis for the plasmids. HR-ICP-MS quantified the plasmid DNA through analysing the phosphorus in DNA molecules. Digital PCR distributed the DNA samples onto a microarray chip containing thousands of reaction chambers, and quantified the DNA copy numbers by analysing the number of positive signals without any calibration curves needed. Based on the high purification of the DNA reference materials and the optimization of dPCR analysis, we successfully achieved good consistency between UV, HR-ICP-MS and dPCR, with relative deviations lower than 10 %. We then performed the co-quantification of 3 DNA RMs with three different methods together, and the uncertainties of their concentration were evaluated. Finally, the certified values and expanded uncertainties for 3 DNA RMs (pFliC, pStx1 and pStx2) were (1.60 ± 0.10) × 10(10) copies/μL, (1.53 ± 0.10) × 10(10) copies/μL and (1.70 ± 0.11) × 10(10) copies/μL respectively.Graphical abstractWe developed 3 plasmid candidate RMs, containing 3 target genes of

Effects of air pollution and seasonality on the respiratory symptoms and health-related quality of life (HR-QoL) of outpatients with chronic respiratory disease in Ulaanbaatar: pilot study for the comparison of the cold and warm seasons.

Science.gov (United States)

Nakao, Motoyuki; Yamauchi, Keiko; Ishihara, Yoko; Solongo, Bandi; Ichinnorov, Dashtseren

2016-01-01

This study was performed to investigate the effects of air pollution and seasonality on the respiratory symptoms and health-related quality of life (HR-QoL) of outpatients with respiratory diseases in Ulaanbaatar, Mongolia. Subjects were outpatients who visited the hospital with chronic obstructive pulmonary diseases (COPD) or bronchial asthma (BA) in March. Their symptoms and HR-QoL were evaluated using a questionnaire including the SF-36v2 and COOP/WONCA charts in March, May and July. PM2.5 was sampled in March and July in Ulaanbaatar, and its composition was analyzed. Patients with COPD or BA showed higher prevalence of respiratory symptoms than the control subjects in each month. For HR-QoL, all subscales worsened in the patients than in the control group in March. Although the HR-QoL of the COPD and control groups were not significantly changed through the surveys, some subscales of the BA group showed remarkable improvement in July as compared to March. Daily means of PM2.5 in March were significantly higher than those in July. Carbon and ionic component concentrations, except for magnesium and calcium ions, were significantly higher in March than July. Mass concentrations of some metallic components were also significantly higher in March than July. The percentage of nitrate ion in PM2.5 was significantly higher in March when compared to that in July. These results suggested that the symptoms in the COPD and BA groups were caused by the disease, and the association with air pollution or seasonality remained unclear. However, the effects of air pollution and seasonality on the HR-QoL were significant in the patients with BA.

Isabella Löhr, Die Globalisierung geistiger Eigentumsrechte. Neue Strukturen internationaler Zusammenarbeit (1886-1952 (Kritische Studien zur Geschichtswissenschaft 195. Vandenhoeck & Ruprecht, Göttingen, 2010, 342 S.

Directory of Open Access Journals (Sweden)

Claudia Lydorf

2013-03-01

Full Text Available In ihrer Dissertation verfolgt Isabella Löhr die Frage, wie sich ausgehend von der nationalen Gesetzgebung des 19. Jh. hin zum Welturheberrechtsabkommen von 1952 der globale Urheberrechtschutz entwickelte. Aus einer globalen Perspektive analysiert die Autorin eine Vielzahl von Aspekten, zum Beispiel den Einfluss des Urheberrechts auf die Entwicklung der Buchproduktion und die herausragende Rolle der Organisationen, die den Urheberrechtsschutz institutionalisierten.

Cell growth and hydrogen production on the mixture of xylose and glucose using a novel strain of Clostridium sp. HR-1 isolated from cow dung compost

Energy Technology Data Exchange (ETDEWEB)

Xu, Ji-Fei; Ren, Nan-Qi; Wang, Ai-Jie; Qiu, Jie; Zhao, Qing-Liang; Feng, Yu-Jie; Liu, Bing-Feng [State Key Laboratory of Urban Water Resource and Environment (SKLUWRE), School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090 (China)

2010-12-15

A novel mesophilic hydrogen-producing bacterium was isolated from cow dung compost and designated as Clostridium sp. HR-1 by 16S rRNA gene sequence. The optimum condition for hydrogen production by strain HR-1 was pH of 6.5, temperature of 37 C and yeast extract as nitrogen sources. The strain HR-1 has the ability to utilize kinds of hexose and pentose as carbon sources for growth and H{sub 2} production. Cell growth and hydrogen productivity were investigated for batch fermentation on media containing different ratios of xylose and glucose. Glucose was the preferred substrate in the glucose and xylose mixtures. The high glucose fraction had higher cell biomass production rate. The rate of glucose consumption was higher than xylose consumption, and remained essentially constant independent of xylose content of the mixture. The rate of xylose utilization was decreased with increasing of the glucose fraction. The average H{sub 2} yield and specific H{sub 2} production rates with xylose and glucose are 1.63 mol-H{sub 2}/mol xylose and 11.14-H{sub 2} mmol/h g-cdw, and 2.02 mol-H{sub 2}/mol-glucose and 9.37 mmol-H{sub 2}/h g-cdw, respectively. Using the same initial substrate concentration, the maximum average H{sub 2} yield and specific H{sub 2} production rates with the mixtures of 9 g/l xylose and 3 g/l glucose was 2.01 mol-H{sub 2}/mol-mixed sugar and 12.56 mmol-H{sub 2}/h g-cdw, respectively. During the fermentation, the main soluble microbial products were ethanol and acetate which showed trends with the different ratios of xylose and glucose. (author)

Remedial design report and remedial action work plan for the 100-HR-3 and 100-KR-4 groundwater operable units' interim action

International Nuclear Information System (INIS)

1996-09-01

This document is a combination remedial design report and remedial action work plan for the 100-HR-3 and 100-KR-4 Operable Units (located on the Hanford Site in Richland, Washington) interim action. The interim actions described in this document represent the first of an ongoing program to address groundwater contamination in each operable unit. This document describes the design basis, provides a description of the interim action, and identifies how they will meet the requirements set forth in the interim action Record of Decision

On Thursday 14 September 2006, members of CERN Management welcomed recently-recruited staff members and fellows at the trimester session of the Induction Programme (photographed here with Enrico CHIAVERI, Department HR).

CERN Multimedia

Maximilien Brice

2006-01-01

On Thursday 14 September 2006, members of CERN Management welcomed recently-recruited staff members and fellows at the trimester session of the Induction Programme (photographed here with Enrico CHIAVERI, Department HR).

Elemental abundance analyses with coadded DAO spectrograms. VI - The mercury-manganese stars Nu Cancri, Iota Coronae Borealis and HR 8349

Science.gov (United States)

Adelman, Saul J.

1989-01-01

The elemental abundances of three mercury-manganese stars, Nu Cancri, Iota Coronae Borealis, and HR 8349, were found to be consistent with previous analyses of this series. As Iota CrB is a double-lined spectroscopic binary with a small velocity amplitude for most of its period, its study required determining whether the observed lines were produced in the primary or secondary or both. The derived abundances and effective termperatures were used along with those of mercury-manganese stars previously analyzed in order to extend the study of probable correlations between abundances, with the effective temperature and surface gravity in accordance with radiative diffusion explanations.

Data validation summary report for the 100-HR-3 Round 8, Phases 1 and 2 groundwater sampling task

International Nuclear Information System (INIS)

1996-01-01

This report presents a summary of data validation results on groundwater samples collected for the 100-HR-3 Round 8 Groundwater Sampling task. The analyses performed for this project consisted of: metals, general chemistry, and radiochemistry. The laboratories conducting the analyses were Quanterra Environmental Services (QES) and Lockheed Analytical Services. As required by the contract and the WHC statement of work (WHC 1994), data validation was conducted using the Westinghouse data validation procedures for chemical and radiochemical analyses (WHC 1993a and 1993b). Sample results were validated to levels A and D as described in the data validation procedures. At the completion of validation and verification of each data package, a data validation summary was prepared and transmitted with the original documentation to Environmental Restoration Contract (ERC) for inclusion in the project QA record

Molecular characterization of genes of Pseudomonas sp. strain HR199 involved in bioconversion of vanillin to protocatechuate.

Science.gov (United States)

Priefert, H; Rabenhorst, J; Steinbüchel, A

1997-01-01

The gene loci vdh, vanA, and vanB, which are involved in the bioconversion of vanillin to protocatechuate by Pseudomonas sp. strain HR199 (DSM 7063), were identified as the structural genes of a novel vanillin dehydrogenase (vdh) and the two subunits of a vanillate demethylase (vanA and vanB), respectively. These genes were localized on an EcoRI fragment (E230), which was cloned from a Pseudomonas sp. strain HR199 genomic library in the cosmid pVK100. The vdh gene was identified on a subfragment (HE35) of E230, and the vanA and vanB genes were localized on a different subfragment (H110) of E230. The nucleotide sequences of fragment HE35 and part of fragment H110 were determined, revealing open reading frames of 1062, 951, and 1446 bp, representing vanA, vanB, and vdh, respectively. The vdh gene was organized in one operon together with a fourth open reading frame (ORF2), of 735 bp, which was located upstream of vdh. The deduced amino acid sequences of vanA and vanB exhibited 78.8 and 62.1% amino acid identity, respectively, to the corresponding gene products from Pseudomonas sp. strain ATCC 19151 (F. Brunel and J. Davison, J. Bacteriol. 170:4924-4930, 1988). The deduced amino acid sequence of the vdh gene exhibited up to 35.3% amino acid identity to aldehyde dehydrogenases from different sources. The deduced amino acid sequence of ORF2 exhibited up to 28.4% amino acid identity to those of enoyl coenzyme A hydratases. Escherichia coli strains harboring fragment E230 cloned in pBluescript SK- converted vanillin to protocatechuate via vanillate, indicating the functional expression of vdh, vanA, and vanB in E. coli. High expression of vdh in E. coli was achieved with HE35 cloned in pBluescript SK-. The resulting recombinant strains converted vanillin to vanillate at a rate of up to 0.3 micromol per min per ml of culture. Transfer of vanA, vanB, and vdh to Alcaligenes eutrophus and to different Pseudomonas strains, which were unable to utilize vanillin or vanillate as

[HPV-Hr detection by home self sampling in women not compliant with pap test for cervical cancer screening. Results of a pilot programme in Bouches-du-Rhône].

Science.gov (United States)

Piana, Lucien; Leandri, François-Xavier; Le Retraite, Laurence; Heid, Patrice; Tamalet, Catherine; Sancho-Garnier, Hélène

2011-07-01

The non-participation to cervical screening is the major determinant in the risk of mortality due to cervical cancer. In France, around 40% of women do not participate to regular screening. The cultural or economic barriers for performing screening by Pap test are numerous; one of the most frequent is the refusal of gynaecological examination. A persistent HPV(HR) infection is a necessary factor for developing cervical cancer. The HPV(HR) testing has a high sensibility to detect high grade cervical intra-epithelial neoplasia (CIN 2-3) and a satisfactory specificity after 30-35 years old. The principal objective of this study was to compare the participation rates in women 35-69 years old who did not perform a Pap test after a first individual invitation, either when an HPV(HR) auto-test was offered to be performed at home or a second invitation to Pap test was sent. We also evaluated the quality of the two tests, the positive results obtained by age groups and the following histological type of lesions diagnosed in the women with positive results. The study included 9,334 women, 35-69 years old, who did not realized a Pap-test during the 2 previous years and who did not respond at a first individual invitation. These non-responders were randomized into two groups: one group (n=4,934) received a second individual invitation and the other (n=4,400) an offer of receiving and performing an HPV auto-test at home. In women 35-69 years the participation to the second invitation to Pap test was significantly lower (7.2%) than the participation to auto-test (26.4%) with Plaw rate is a consequence of an inversion of the ratio HPV 16 versus other types in women 60 years old and over. In this group, the follow-up of 36 women diagnosed five cases of CIN1, one of CIN2 and four of CIN3; 22 patients are lost of follow up at 6 months. Globally, in the studied population, an individual recall for pap test allowed to diagnose and treat 3 high grade lesions (7‰) and the dispatching

Indigenous development of 20 Cu. M/hr flat linear induction pump (Paper No. 047)

Energy Technology Data Exchange (ETDEWEB)

Prabhakar, R; Prakash, V; Sundarasekaran, S

1987-01-01

A distinctive physical property of sodium metal which is used as a coolant in fast reactors, is its high electrical conductivity. This together with its ability to wet stainless steel permits fluid pumping techniques using electromagnetic devices. Electromagnetic pumps are analogous to the electric motor, in which a force is produced by the interaction of magnetic field and current flowing in a conductor. Flat linear induction pump (FLIP) whose operating principle is similar to that of an induction motor is one of the types of electromagnetic pumps in wide use in auxilary circuits of fast reactors. As part of efforts to develop fast reactor components indigenously, work on the design and construction of a prototype FLIP rated for 20Cu.M/hr and 5Kg/sq.cm at 550degC was initiated. Under Board of Research in Nuclear Sciences scheme, the design was carried out by the Electrical Engineering Department of IIT, Madras. Pump was constructed at Engineering Development Division, Indira Gandhi Centre for Atomic Research, Kalpakkam. This paper presents in detail the work carried out for the fabrication of flow channel and for the stator assembly. Results obtained from dry electrical tests are also reported. Appendix summarises the design data. (author).

Practical consensus recommendations on management of HR + ve early breast cancer with specific reference to genomic profiling

Directory of Open Access Journals (Sweden)

S Aggarwal

2018-01-01

Full Text Available Breast cancer is a heterogeneous disease and patients are managed clinically based on ER, PR, HER2 expression, and key risk factors. The use of gene expression assays for early stage disease is already common practice. These tests have found a place in risk stratifying the heterogeneous group of stage I–II breast cancers for recurrence, for predicting chemotherapy response, and for predicting breast cancer-related mortality. Most guidelines for hormone receptor (HR–positive early breast cancer recommend addition of adjuvant chemotherapy for most women, leading to overtreatment, which causes considerable morbidity and cost. Expert oncologist discussed about strategies of gene expression assays and aid in chemotherapy recommendations for treatment of HR + ve EBC and the expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at this practical consensus recommendations for the benefit of community oncologists.

The use of gelatine in long-term storage (up to 48 hr) at 5°C preserves the pre-freezing and post-thawing quality of brown bear sperm.

Science.gov (United States)

Lopez-Urueña, E; Anel-López, L; Borragan, S; Ortega Ferrusola, C; Manrique, P; de Paz, P; Anel, L; Alvarez, M

2016-10-01

Sedimentation of spermatozoa occurs during long-term liquid storage and this may produce deleterious changes. Our aim was to apply gelatine supplementation during long-term pre-freezing storage of bear sperm, applying final dilution and 6% glycerol at room temperature and cool in straws. We tested four models of sperm storage using a 1:1 dilution in TTF-ULE-Bear extender (TesT-fructose-egg yolk-glycerol 6%): (i) second 1:1 dilution at room temperature (RT), cooling at 5°C in a tube and final dilution (100 × 10(6)  sperm ml(-1) ) (Standard); (ii) final dilution at RT and cooling in a tube (FD-Tube); (iii) final dilution at RT and cooling in 0.25 ml plastic straw (FD-Straw); and (iv) final dilution at RT in extender supplemented with 1.5% gelatine (Gelatine) and cooling in a 0.25 ml plastic straw. A Standard sample was stored at 5°C for 1 hr (Control); the rest of the samples (Standard, FD-Tube, FD-Straw, Gelatine) were stored for 24 or 48 hrs before freezing (100 × 10(6)  sperm ml(-1) , glycerol 6%). The quality of the samples was assessed for motility by CASA, and viability (SYBR-14/propidium iodide-PI-; VIAB), acrosomal status (PNA-FITC/PI; iACR) and apoptotic status (YO-PRO-1/PI; YOPRO-) by flow cytometry. At pre-freezing, after 48 hr, Gelatine showed significantly higher viability (for VIAB and YOPRO-) and progressiveness (PM, LIN and STR). At 48 hr, Gelatine showed similar YOPRO-, iACR, LIN, STR and ALH respect to Control. At both 24 and 48 h post-thawing, Gelatine sample had similar scores for YOPRO-, iACR, LIN, STR, WOB and VIAB (only 24 hr) when compared with Control, and lower for TM, PM, rapidPM, VAP and ALH. No differences were found among others experimental groups with respect to Control. In conclusion, gelatine could be a suitable alternative to preserve the viability and progressive motility of brown bear ejaculates during long-term pre-freezing storage at 5°C. © 2016 Blackwell Verlag GmbH.

The benefit of the Dutch Energy Investment Allowance (EIA) for high-efficiency installations in industrial buildings; EIA maakt hr-apparatuur voor bedrijfsgebouwen voordelig

Energy Technology Data Exchange (ETDEWEB)

De Boer, A. [ed.

1998-02-01

Gas-fired condensing appliances for space heating of industrial buildings are more expensive than appliances that do not show a high efficiency. In many cases, however, it is still cheaper to invest in condensing appliances. Not only because of lower exploitation costs, but also because of the ISO-high-efficiency subsidy regulation (`ISO-hr`), the energy investment allowance (EIA) and the energy conservation fund. The technologies that are eligible for the EIA are listed in the `Energielijst` (energy list) for 1998

PDK1 and HR46 gene homologs tie social behavior to ovary signals.

Directory of Open Access Journals (Sweden)

Ying Wang

Full Text Available The genetic basis of division of labor in social insects is a central question in evolutionary and behavioral biology. The honey bee is a model for studying evolutionary behavioral genetics because of its well characterized age-correlated division of labor. After an initial period of within-nest tasks, 2-3 week-old worker bees begin foraging outside the nest. Individuals often specialize by biasing their foraging efforts toward collecting pollen or nectar. Efforts to explain the origins of foraging specialization suggest that division of labor between nectar and pollen foraging specialists is influenced by genes with effects on reproductive physiology. Quantitative trait loci (QTL mapping of foraging behavior also reveals candidate genes for reproductive traits. Here, we address the linkage of reproductive anatomy to behavior, using backcross QTL analysis, behavioral and anatomical phenotyping, candidate gene expression studies, and backcross confirmation of gene-to-anatomical trait associations. Our data show for the first time that the activity of two positional candidate genes for behavior, PDK1 and HR46, have direct genetic relationships to ovary size, a central reproductive trait that correlates with the nectar and pollen foraging bias of workers. These findings implicate two genes that were not known previously to influence complex social behavior. Also, they outline how selection may have acted on gene networks that affect reproductive resource allocation and behavior to facilitate the evolution of social foraging in honey bees.

Luminous and Variable Stars in M31 and M33. V. The Upper HR Diagram

Energy Technology Data Exchange (ETDEWEB)

Humphreys, Roberta M.; Davidson, Kris; Hahn, David [Minnesota Institute for Astrophysics, 116 Church St SE, University of Minnesota, Minneapolis, MN 55455 (United States); Martin, John C. [Barber Observatory, University of Illinois, Springfield, IL 62703 (United States); Weis, Kerstin, E-mail: roberta@umn.edu [Astronomical Institute, Ruhr-Universitaet Bochum (Germany)

2017-07-20

We present HR diagrams for the massive star populations in M31 and M33, including several different types of emission-line stars: the confirmed luminous blue variables (LBVs), candidate LBVs, B[e] supergiants, and the warm hypergiants. We estimate their apparent temperatures and luminosities for comparison with their respective massive star populations and evaluate the possible relationships of these different classes of evolved, massive stars, and their evolutionary state. Several of the LBV candidates lie near the LBV/S Dor instability strip that supports their classification. Most of the B[e] supergiants, however, are less luminous than the LBVs. Many are very dusty with the infrared flux contributing one-third or more to their total flux. They are also relatively isolated from other luminous OB stars. Overall, their spatial distribution suggests a more evolved state. Some may be post-RSGs (red supergiants) like the warm hypergiants, and there may be more than one path to becoming a B[e] star. There are sufficient differences in the spectra, luminosities, spatial distribution, and the presence or lack of dust between the LBVs and B[e] supergiants to conclude that one group does not evolve into the other.

Case note: HR (nr. C06/278HR)

NARCIS (Netherlands)

Verhulp, E.

2008-01-01

Bovenwettelijke doorbetaling loon bij arbeidsongeschiktheid o.g.v. CAO; verdergaande uitsluiting aanspraak dan voorzien in art. 7:629 BW geoorloofd?; ‘schuld of toedoen’ in zin CAO: uitleg; sportblessure door schuld of toedoen? Dat art. 7:629 lid 3 onder a BW de werknemer het recht op doorbetaling

Clouds and Chemistry in the Atmosphere of Extrasolar Planet HR8799b

Energy Technology Data Exchange (ETDEWEB)

Barman, T S; Macintosh, B A; Konopacky, Q M; Marois, C

2011-03-21

Using the integral field spectrograph OSIRIS, on the Keck II telescope, broad near-infrared H and K-band spectra of the young exoplanet HR8799b have been obtained. In addition, six new narrow-band photometric measurements have been taken across the H and K bands. These data are combined with previously published photometry for an analysis of the planet's atmospheric properties. Thick photospheric dust cloud opacity is invoked to explain the planet's red near-IR colors and relatively smooth near-IR spectrum. Strong water absorption is detected, indicating a Hydrogen-rich atmosphere. Only weak CH{sub 4} absorption is detected at K band, indicating efficient vertical mixing and a disequilibrium CO/CH{sub 4} ratio at photospheric depths. The H-band spectrum has a distinct triangular shape consistent with low surface gravity. New giant planet atmosphere models are compared to these data with best fitting bulk parameters, T{sub eff} = 1100K {+-} 100 and log(g) = 3.5 {+-} 0.5 (for solar composition). Given the observed luminosity (log L{sub obs}/L{sub {circle_dot}} {approx} -5.1), these values correspond to a radius of 0.75 R{sub Jup{sub 0.12}{sup +0.17}} and mass {approx} 0.72 M{sub Jup{sub -0.6}{sup +2.6}} - strikingly inconsistent with interior/evolution models. Enhanced metallicity (up to {approx} 10 x that of the Sun) along with thick clouds and non-equilibrium chemistry are likely required to reproduce the complete ensemble of spectroscopic and photometric data and the low effective temperatures (< 1000K) required by the evolution models.

EVALUATION OF INTERNALLY STAGED COAL BURNERS AND SORBENT JET AERODYNAMICS FOR COMBINED SO2/NOX CONTROL IN UTILITY BOILERS; VOLUME 2. TESTING IN A 100 MILLION BTU/HR EXPERIMENTAL FURNACE

Science.gov (United States)

The report givesresults of100 million Btu/hr (29 MWt) experimental furnace to explore methods for achieving effective S02 removal in a coalfired utility boiler using calcium-based sorbents, through appropriate selection of injection location and injector design/operating paramete...

Evaluation of Creep Strength of Heterogeneous Welded Joint in HR6W Alloy and Sanicro 25 Steel

Directory of Open Access Journals (Sweden)

Zieliński A.

2017-12-01

Full Text Available This article presents the results of investigations on HR6W alloy and Sanicro 25 steel and the dissimilar welded joint made of them. The characteristic images of microstructure of the investigated materials in the as-received condition and following the creep test, observed with a scanning electron microscope (SEM, are shown. The X-ray analysis of phase composition of the existing precipitates was carried out. The method for evaluation of creep strength based on abridged creep tests carried out at a temperature higher than the design one is presented. The obtained results do not deviate from the values of creep strength determined in long-term creep tests. The maximum difference in creep strength of the investigated materials is ±20%, which is in compliance with the acceptable scatter band. The methodology presented can be used for verification of creep strength (life time of the material of finished components to be operated under creep conditions.

Investigation of the nanoscale two-component ZnS-ZnO heterostructures by means of HR-TEM and X-ray based analysis

Science.gov (United States)

Pankin, I. A.; Polozhentsev, O. E.; Soldatov, M. A.; Bugaev, A. L.; Tsaturyan, A.; Lomachenko, K. A.; Guda, A. A.; Budnyk, A. P.; Lamberti, C.; Soldatov, A. V.

2018-06-01

This article is devoted to the spectroscopic characterization of ZnS-ZnO nanoscale heterostructures synthesized by the microwave-assisted solvothermal method. The synthesized samples were investigated by means of X-ray powder diffraction (XRPD), high energy resolution fluorescence detected X-ray absorption near-edge-structure (HERFD-XANES) spectroscopy, valence-to-core X-ray emission spectroscopy (VtC-XES) and high resolution transmission electron microscopy (HR-TEM) as well as energy dispersive X-ray spectroscopy (EDX). The average crystallite size estimated by the broadening of XRPD peaks increases from 2.7 nm to 3.7 nm in the temperature range from 100 °C to 150 °C. HR-TEM images show that nanoparticles are arranged in aggregates with the 60-200 nm size. Theoretical estimation shows that the systems synthesized at higher temperatures more prone to the agglomeration. The full profile Reitveld analysis of XRPD data reveals the formation of hexagonal zinc sulfide structure, whereas electron diffraction data reveal also the formation of cubic zinc sulfide and claim the polymorphous character of the system. High energy resolution Zn K-edge XANES data unambiguously demonstrate the presence of a certain amount of the zinc oxide which is likely to have an amorphous structure and could not be detected by XRPD. Qualitative analysis of XANES data allows deriving ZnS/ZnO ratio as a function of synthesis temperature. EDX analysis depicts homogeneous distribution of ZnS and amorphous ZnO phases across the conglomerates. A complementary element-selective valence to core X-ray emission spectroscopy evidences formation of two-component system and confirms estimations of ZnS/ZnO fractions obtained by linear combination fit of XANES data.

Metabolism of the new psychoactive substances N,N-diallyltryptamine (DALT) and 5-methoxy-DALT and their detectability in urine by GC-MS, LC-MSn, and LC-HR-MS-MS.

Science.gov (United States)

Michely, Julian A; Helfer, Andreas G; Brandt, Simon D; Meyer, Markus R; Maurer, Hans H

2015-10-01

N,N-Diallyltryptamine (DALT) and 5-methoxy-DALT (5-MeO-DALT) are synthetic tryptamine derivatives commonly referred to as so-called new psychoactive substances (NPS). They have psychoactive effects that may be similar to those of other tryptamine derivatives. The objectives of this work were to study the metabolic fate and detectability, in urine, of DALT and 5-MeO-DALT. For metabolism studies, rat urine obtained after high-dose administration was prepared by precipitation and analyzed by liquid chromatography-high-resolution mass spectrometry (LC-HR-MS-MS). On the basis of the metabolites identified, several aromatic and aliphatic hydroxylations, N-dealkylation, N-oxidation, and combinations thereof are proposed as the main metabolic pathways for both compounds. O-Demethylation of 5-MeO-DALT was also observed, in addition to extensive glucuronidation or sulfation of both compounds after phase I transformation. The cytochrome P450 (CYP) isoenzymes predominantly involved in DALT metabolism were CYP2C19, CYP2D6, and CYP3A4; those mainly involved in 5-MeO-DALT metabolism were CYP1A2, CYP2C19, CYP2D6, and CYP3A4. For detectability studies, rat urine was screened by GC-MS, LC-MS(n), and LC-HR-MS-MS after administration of low doses. LC-MS(n) and LC-HR-MS-MS were deemed suitable for monitoring consumption of both compounds. The most abundant targets were a ring hydroxy metabolite of DALT, the N,O-bis-dealkyl metabolite of 5-MeO-DALT, and their glucuronides. GC-MS enabled screening of DALT by use of its main metabolites only.

Experimental wear behavioral studies of as-cast and 5 hr homogenized Al25Mg2Si2Cu4Ni alloy at constant load based on taguchi method

Science.gov (United States)

Harlapur, M. D.; Mallapur, D. G.; Udupa, K. Rajendra

2018-04-01

In the present study, an experimental study of the volumetric wear behaviour of Aluminium (Al-25Mg2Si2Cu4Ni) alloy in as cast and 5Hr homogenized with T6 heat treatment is carried out at constant load. The Pin on disc apparatus was used to carry out the sliding wear test. Taguchi method based on L-16 orthogonal array was employed to evaluate the data on the wear behavior. Signal-to-noise ratio among the objective of smaller the better and mean of means results were used. General regression model is obtained by correlation. Lastly confirmation test was completed to compose a comparison between the experimental results foreseen from the mention correlation. The mathematical model reveals the load has maximum contribution on the wear rate compared to speed. Scanning Electron Microscope was used to analyze the worn-out wear surfaces. Wear results show that 5Hr homogenized Al-25Mg2Si2Cu4Ni alloy samples with T6 treated had better volumetric wear resistance as compared to as cast samples.

I-123 IBZM-SPECT: improved acquisition protocol with HR-collimator

International Nuclear Information System (INIS)

Sandrock, D.; Ivancevic, V.; Dopichaj-Menge, U.; Gruber, D.; Munz, D.

2002-01-01

protocol A and 3 patients with protocol B. These could not properly staged as normal or abnormal. Conclusion: The acquisition protocol using a HR collimator and a 128 x 128 matrix in I-123 IBZM-SPECT leads to a more valid determination of the dopamine D2 receptor status

Solid-phase extraction and separation procedure for trace aluminum in water samples and its determination by high-resolution continuum source flame atomic absorption spectrometry (HR-CS FAAS).

Science.gov (United States)

Ciftci, Harun; Er, Cigdem

2013-03-01

In the present study, a separation/preconcentration procedure for determination of aluminum in water samples has been developed by using a new atomic absorption spectrometer concept with a high-intensity xenon short-arc lamp as continuum radiation source, a high-resolution double-echelle monochromator, and a charge-coupled device array detector. Sample solution pH, sample volume, flow rate of sample solution, volume, and concentration of eluent for solid-phase extraction of Al chelates with 4-[(dicyanomethyl)diazenyl] benzoic acid on polymeric resin (Duolite XAD-761) have been investigated. The adsorbed aluminum on resin was eluted with 5 mL of 2 mol L(-1) HNO(3) and its concentration was determined by high-resolution continuum source flame atomic absorption spectrometry (HR-CS FAAS). Under the optimal conditions, limit of detection obtained with HR-CS FAAS and Line Source FAAS (LS-FAAS) were 0.49 μg L(-1) and 3.91 μg L(-1), respectively. The accuracy of the procedure was confirmed by analyzing certified materials (NIST SRM 1643e, Trace elements in water) and spiked real samples. The developed procedure was successfully applied to water samples.

Molecular Characterization of the Genes pcaG and pcaH, Encoding Protocatechuate 3,4-Dioxygenase, Which Are Essential for Vanillin Catabolism in Pseudomonas sp. Strain HR199

Science.gov (United States)

Overhage, Jörg; Kresse, Andreas U.; Priefert, Horst; Sommer, Horst; Krammer, Gerhard; Rabenhorst, Jürgen; Steinbüchel, Alexander

1999-01-01

Pseudomonas sp. strain HR199 is able to utilize eugenol (4-allyl-2-methoxyphenol), vanillin (4-hydroxy-3-methoxybenzaldehyde), or protocatechuate as the sole carbon source for growth. Mutants of this strain which were impaired in the catabolism of vanillin but retained the ability to utilize eugenol or protocatechuate were obtained after nitrosoguanidine mutagenesis. One mutant (SK6169) was used as recipient of a Pseudomonas sp. strain HR199 genomic library in cosmid pVK100, and phenotypic complementation was achieved with a 5.8-kbp EcoRI fragment (E58). The amino acid sequences deduced from two corresponding open reading frames (ORF) identified on E58 revealed high degrees of homology to pcaG and pcaH, encoding the two subunits of protocatechuate 3,4-dioxygenase. Three additional ORF most probably encoded a 4-hydroxybenzoate 3-hydroxylase (PobA) and two putative regulatory proteins, which exhibited homology to PcaQ of Agrobacterium tumefaciens and PobR of Pseudomonas aeruginosa, respectively. Since mutant SK6169 was also complemented by a subfragment of E58 that harbored only pcaH, this mutant was most probably lacking a functional β subunit of the protocatechuate 3,4-dioxygenase. Since this mutant was still able to grow on protocatechuate and lacked protocatechuate 4,5-dioxygenase and protocatechuate 2,3-dioxygenase, the degradation had to be catalyzed by different enzymes. Two other mutants (SK6184 and SK6190), which were also impaired in the catabolism of vanillin, were not complemented by fragment E58. Since these mutants accumulated 3-carboxy muconolactone during cultivation on eugenol, they most probably exhibited a defect in a step of the catabolic pathway following the ortho cleavage. Moreover, in these mutants cyclization of 3-carboxymuconic acid seems to occur by a syn absolute stereochemical course, which is normally only observed for cis,cis-muconate lactonization in pseudomonads. In conclusion, vanillin is degraded through the ortho-cleavage pathway

EPISODIC ACCRETION AT EARLY STAGES OF EVOLUTION OF LOW-MASS STARS AND BROWN DWARFS: A SOLUTION FOR THE OBSERVED LUMINOSITY SPREAD IN H-R DIAGRAMS?

International Nuclear Information System (INIS)

Baraffe, I.; Chabrier, G.; Gallardo, J.

2009-01-01

We present evolutionary models for young low-mass stars and brown dwarfs taking into account episodic phases of accretion at early stages of the evolution, a scenario supported by recent large surveys of embedded protostars. An evolution including short episodes of vigorous accretion followed by longer quiescent phases can explain the observed luminosity spread in H-R diagrams of star-forming regions at ages of a few Myr, for objects ranging from a few Jupiter masses to a few tenths of a solar mass. The gravitational contraction of these accreting objects strongly departs from the standard Hayashi track at constant T eff . The best agreement with the observed luminosity scatter is obtained if most of the accretion shock energy is radiated away. The obtained luminosity spread at 1 Myr in the H-R diagram is equivalent to what can be misinterpreted as an ∼10 Myr age spread for non-accreting objects. We also predict a significant spread in radius at a given T eff , as suggested by recent observations. These calculations bear important consequences for our understanding of star formation and early stages of evolution and on the determination of the initial mass function for young (≤ a few Myr) clusters. Our results also show that the concept of a stellar birthline for low-mass objects has no valid support.

Investigation of HV/HR-CMOS technology for the ATLAS Phase-II Strip Tracker Upgrade

International Nuclear Information System (INIS)

Fadeyev, V.; Galloway, Z.; Grabas, H.; Grillo, A.A.; Liang, Z.; Martinez-Mckinney, F.; Seiden, A.; Volk, J.; Affolder, A.; Buckland, M.; Meng, L.; Arndt, K.; Bortoletto, D.; Huffman, T.; John, J.; McMahon, S.; Nickerson, R.; Phillips, P.; Plackett, R.; Shipsey, I.

2016-01-01

ATLAS has formed strip CMOS project to study the use of CMOS MAPS devices as silicon strip sensors for the Phase-II Strip Tracker Upgrade. This choice of sensors promises several advantages over the conventional baseline design, such as better resolution, less material in the tracking volume, and faster construction speed. At the same time, many design features of the sensors are driven by the requirement of minimizing the impact on the rest of the detector. Hence the target devices feature long pixels which are grouped to form a virtual strip with binary-encoded z position. The key performance aspects are radiation hardness compatibility with HL-LHC environment, as well as extraction of the full hit position with full-reticle readout architecture. To date, several test chips have been submitted using two different CMOS technologies. The AMS 350 nm is a high voltage CMOS process (HV-CMOS), that features the sensor bias of up to 120 V. The TowerJazz 180 nm high resistivity CMOS process (HR-CMOS) uses a high resistivity epitaxial layer to provide the depletion region on top of the substrate. We have evaluated passive pixel performance, and charge collection projections. The results strongly support the radiation tolerance of these devices to radiation dose of the HL-LHC in the strip tracker region. We also describe design features for the next chip submission that are motivated by our technology evaluation.

Investigation of HV/HR-CMOS technology for the ATLAS Phase-II Strip Tracker Upgrade

Science.gov (United States)

Fadeyev, V.; Galloway, Z.; Grabas, H.; Grillo, A. A.; Liang, Z.; Martinez-Mckinney, F.; Seiden, A.; Volk, J.; Affolder, A.; Buckland, M.; Meng, L.; Arndt, K.; Bortoletto, D.; Huffman, T.; John, J.; McMahon, S.; Nickerson, R.; Phillips, P.; Plackett, R.; Shipsey, I.; Vigani, L.; Bates, R.; Blue, A.; Buttar, C.; Kanisauskas, K.; Maneuski, D.; Benoit, M.; Di Bello, F.; Caragiulo, P.; Dragone, A.; Grenier, P.; Kenney, C.; Rubbo, F.; Segal, J.; Su, D.; Tamma, C.; Das, D.; Dopke, J.; Turchetta, R.; Wilson, F.; Worm, S.; Ehrler, F.; Peric, I.; Gregor, I. M.; Stanitzki, M.; Hoeferkamp, M.; Seidel, S.; Hommels, L. B. A.; Kramberger, G.; Mandić, I.; Mikuž, M.; Muenstermann, D.; Wang, R.; Zhang, J.; Warren, M.; Song, W.; Xiu, Q.; Zhu, H.

2016-09-01

ATLAS has formed strip CMOS project to study the use of CMOS MAPS devices as silicon strip sensors for the Phase-II Strip Tracker Upgrade. This choice of sensors promises several advantages over the conventional baseline design, such as better resolution, less material in the tracking volume, and faster construction speed. At the same time, many design features of the sensors are driven by the requirement of minimizing the impact on the rest of the detector. Hence the target devices feature long pixels which are grouped to form a virtual strip with binary-encoded z position. The key performance aspects are radiation hardness compatibility with HL-LHC environment, as well as extraction of the full hit position with full-reticle readout architecture. To date, several test chips have been submitted using two different CMOS technologies. The AMS 350 nm is a high voltage CMOS process (HV-CMOS), that features the sensor bias of up to 120 V. The TowerJazz 180 nm high resistivity CMOS process (HR-CMOS) uses a high resistivity epitaxial layer to provide the depletion region on top of the substrate. We have evaluated passive pixel performance, and charge collection projections. The results strongly support the radiation tolerance of these devices to radiation dose of the HL-LHC in the strip tracker region. We also describe design features for the next chip submission that are motivated by our technology evaluation.

Investigation of HV/HR-CMOS technology for the ATLAS Phase-II Strip Tracker Upgrade

Energy Technology Data Exchange (ETDEWEB)

Fadeyev, V., E-mail: fadeyev@ucsc.edu [Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA 95064 (United States); Galloway, Z.; Grabas, H.; Grillo, A.A.; Liang, Z.; Martinez-Mckinney, F.; Seiden, A.; Volk, J. [Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA 95064 (United States); Affolder, A.; Buckland, M.; Meng, L. [Department of Physics, University of Liverpool, O. Lodge Laboratory, Oxford Street, Liverpool L69 7ZE (United Kingdom); Arndt, K.; Bortoletto, D.; Huffman, T.; John, J.; McMahon, S.; Nickerson, R.; Phillips, P.; Plackett, R.; Shipsey, I. [Department of Physics, Oxford University, Oxford (United Kingdom); and others

2016-09-21

ATLAS has formed strip CMOS project to study the use of CMOS MAPS devices as silicon strip sensors for the Phase-II Strip Tracker Upgrade. This choice of sensors promises several advantages over the conventional baseline design, such as better resolution, less material in the tracking volume, and faster construction speed. At the same time, many design features of the sensors are driven by the requirement of minimizing the impact on the rest of the detector. Hence the target devices feature long pixels which are grouped to form a virtual strip with binary-encoded z position. The key performance aspects are radiation hardness compatibility with HL-LHC environment, as well as extraction of the full hit position with full-reticle readout architecture. To date, several test chips have been submitted using two different CMOS technologies. The AMS 350 nm is a high voltage CMOS process (HV-CMOS), that features the sensor bias of up to 120 V. The TowerJazz 180 nm high resistivity CMOS process (HR-CMOS) uses a high resistivity epitaxial layer to provide the depletion region on top of the substrate. We have evaluated passive pixel performance, and charge collection projections. The results strongly support the radiation tolerance of these devices to radiation dose of the HL-LHC in the strip tracker region. We also describe design features for the next chip submission that are motivated by our technology evaluation.

Memorandum from the HR Department and the Legal Service concerning income tax declarations for 2006 in SWITZERLAND

CERN Document Server

2007-01-01

As the Swiss authorities have yet to make known their instructions on how to complete the income tax declaration forms for 2006, members of the CERN personnel who have received or may receive an income tax declaration form must request an extension of the deadline for returning the form to their tax office. Canton of Geneva Declaration forms must be returned by 31 March. An extension to 30 June can be obtained by telephone (stating your tax number) by calling 022 327 49 00 before 31 March. Canton of Vaud Declaration forms must be returned by 15 March. An extension to 15 June can be obtained by telephone (stating your tax number) by calling 021 316 00 00 before 15 March. Canton of Valais Declaration forms must be returned by 31 March. An extension to 31 July can be obtained from the relevant tax office. Please contact the HR Department for further information. Canton of Fribourg Declaration forms must be returned by 31 March. Requests for extensions should be submitted in writing (stating your tax num...

H.R. 3173: A Bill to apply the provisions of OSHA to certain Department of Energy nuclear facilities. Introduced in the House of Representatives, One Hundredth First Congress, First Session, August 4, 1989

International Nuclear Information System (INIS)

Anon.

1989-01-01

H.R. 3173: A Bill to apply the provisions of OSHA to certain Department of Energy (DOE) nuclear facilities. The purpose is to improve and enforce standards for employee health and safety at DOE nuclear facilities

AirCore-HR: a high-resolution column sampling to enhance the vertical description of CH4 and CO2

Directory of Open Access Journals (Sweden)

O. Membrive

2017-06-01

Full Text Available An original and innovative sampling system called AirCore was presented by NOAA in 2010 (Karion et al., 2010. It consists of a long (>  100 m and narrow (<  1 cm stainless steel tube that can retain a profile of atmospheric air. The captured air sample has then to be analyzed with a gas analyzer for trace mole fraction. In this study, we introduce a new AirCore aiming to improve resolution along the vertical with the objectives to (i better capture the vertical distribution of CO2 and CH4, (ii provide a tool to compare AirCores and validate the estimated vertical resolution achieved by AirCores. This (high-resolution AirCore-HR consists of a 300 m tube, combining 200 m of 0.125 in. (3.175 mm tube and a 100 m of 0.25 in. (6.35 mm tube. This new configuration allows us to achieve a vertical resolution of 300 m up to 15 km and better than 500 m up to 22 km (if analysis of the retained sample is performed within 3 h. The AirCore-HR was flown for the first time during the annual StratoScience campaign from CNES in August 2014 from Timmins (Ontario, Canada. High-resolution vertical profiles of CO2 and CH4 up to 25 km were successfully retrieved. These profiles revealed well-defined transport structures in the troposphere (also seen in CAMS-ECMWF high-resolution forecasts of CO2 and CH4 profiles and captured the decrease of CO2 and CH4 in the stratosphere. The multi-instrument gondola also carried two other low-resolution AirCore-GUF that allowed us to perform direct comparisons and study the underlying processing method used to convert the sample of air to greenhouse gases vertical profiles. In particular, degrading the AirCore-HR derived profiles to the low resolution of AirCore-GUF yields an excellent match between both sets of CH4 profiles and shows a good consistency in terms of vertical structures. This fully validates the theoretical vertical resolution achievable by AirCores. Concerning CO2 although a

The bifurcations of nearly flat origami

Science.gov (United States)

Santangelo, Christian

Self-folding origami structures provide one means of fabricating complex, three-dimensional structures from a flat, two-dimensional sheet. Self-folding origami structures have been fabricated on scales ranging from macroscopic to microscopic and can have quite complicated structures with hundreds of folds arranged in complex patterns. I will describe our efforts to understand the mechanics and energetics of self-folding origami structures. Though the dimension of the configuration space of an origami structure scales with the size of the boundary and not with the number of vertices in the interior of the structure, a typical origami structure is also floppy in the sense that there are many possible ways to assign fold angles consistently. I will discuss our theoretical progress in understanding the geometry of the configuration space of origami. For random origami, the number of possible bifurcations grows surprisingly quickly even when the dimension of the configuration space is small. EFRI ODISSEI-1240441, DMR-0846582.

Butterfly proboscis: natural combination of a drinking straw with a nanosponge

Science.gov (United States)

Kornev, Kostya; Monaenkova, Daria; Adler, Peter; Lee, Wah-Keat; Lehnert, Matthew; Andrukh, Taras; Beard, Charles; Rubin, Binyamin; Tokarev, Alexander

2011-11-01

The ability of Lepidoptera, or butterflies and moths, to drink liquids from rotting fruit and wet soil, as well as nectar from floral tubes, raises the question of whether the conventional view of the proboscis as a drinking straw can account for the withdrawal of fluids from porous substrates or of films and droplets from floral tubes. We discovered that the proboscis promotes capillary pull of liquids from diverse sources due to a hierarchical pore structure spanning nano- and microscales. X-ray phase-contrast imaging reveals that Plateau instability causes liquid bridges to form in the food canal, which are transported to the gut by the muscular sucking pump in the head. The dual functionality of the proboscis represents a key innovation for exploiting a vast range of nutritional sources. A transformative two-step model of capillary intake and suctioning can be applied not only to butterflies and moths but also potentially to vast numbers of other insects such as bees and flies. NSF EFRI - 0937985.

A Bill to Amend the Intergovernmental Cooperation Act of 1968 to Improve . . . Strengthening of State and Local Offices of Consumer Protection. H.R. 2198. 95th Congress, 1st Session.

Science.gov (United States)

Congress of the U.S., Washington, DC.

This U.S. House of Representatives bill (H.R. 2198), to be cited, if enacted, as the Intergovernmental Consumer Assistance Act, would add a new title to the Intergovernmental Cooperation Act of 1968: Title VII-Intergovernmental Cooperation with Respect to Consumer Assistance and Protection. The objective is to establish greater cooperation among…

Financial fallout from Three Mile Island. Hearings before the Subcommittee on Energy Conservation and Power of the Committee on Energy and Commerce, House of Representatives, Ninety-Seventh Congress, First Session, H.R. 2512, May 1 and September 22, 1981

International Nuclear Information System (INIS)

Anon.

1982-01-01

This hearing, the first in a series, on how to finance cleanup costs and damage compensation after a nuclear accident began with testimony from those involved in the Three Mile Island accident. The testimony covers the limitations of the Price-Anderson Act and examines H.R. 2512, which provides supplemental insurance to cover the costs of remedial action. Among the recommendations was the possibility of having operators and manufacturers share in the costs. The hearing record includes the text of H.R. 2512, a report from the Securities Exchange Commission, the testimony of 14 witnesses, and additional material submitted for the record

H.R. 1098: A Bill to establish a wholly-owned Government corporation to manage the Nation's uranium enrichment enterprise. Introduced in the House of Representatives, One Hundredth First Congress, First Session, February 23, 1989

International Nuclear Information System (INIS)

Anon.

1989-01-01

H.R. 1098 is a bill to establish a wholly-owned Government corporation to manage the Nation's uranium enrichment enterprise, operating as a continuing commercial enterprise on a profitable and efficient basis, and for other purposes

Ribociclib plus letrozole versus letrozole alone in patients with de novo HR+, HER2- advanced breast cancer in the randomized MONALEESA-2 trial.

Science.gov (United States)

O'Shaughnessy, Joyce; Petrakova, Katarina; Sonke, Gabe S; Conte, Pierfranco; Arteaga, Carlos L; Cameron, David A; Hart, Lowell L; Villanueva, Cristian; Jakobsen, Erik; Beck, Joseph T; Lindquist, Deborah; Souami, Farida; Mondal, Shoubhik; Germa, Caroline; Hortobagyi, Gabriel N

2018-02-01

Determine the efficacy and safety of first-line ribociclib plus letrozole in patients with de novo advanced breast cancer. Postmenopausal women with HR+ , HER2- advanced breast cancer and no prior systemic therapy for advanced disease were enrolled in the Phase III MONALEESA-2 trial (NCT01958021). Patients were randomized to ribociclib (600 mg/day; 3 weeks-on/1 week-off) plus letrozole (2.5 mg/day; continuous) or placebo plus letrozole until disease progression, unacceptable toxicity, death, or treatment discontinuation. The primary endpoint was investigator-assessed progression-free survival; predefined subgroup analysis evaluated progression-free survival in patients with de novo advanced breast cancer. Secondary endpoints included safety and overall response rate. Six hundred and sixty-eight patients were enrolled, of whom 227 patients (34%; ribociclib plus letrozole vs placebo plus letrozole arm: n = 114 vs. n = 113) presented with de novo advanced breast cancer. Median progression-free survival was not reached in the ribociclib plus letrozole arm versus 16.4 months in the placebo plus letrozole arm in patients with de novo advanced breast cancer (hazard ratio 0.45, 95% confidence interval 0.27-0.75). The most common Grade 3/4 adverse events were neutropenia and leukopenia; incidence rates were similar to those observed in the full MONALEESA-2 population. Ribociclib dose interruptions and reductions in patients with de novo disease occurred at similar frequencies to the overall study population. Ribociclib plus letrozole improved progression-free survival vs placebo plus letrozole and was well tolerated in postmenopausal women with HR+, HER2- de novo advanced breast cancer.

Aquatic studies at the 100-HR-3 and 100-NR-1 operable units

International Nuclear Information System (INIS)

Cushing, C.E.

1993-04-01

Pacific Northwest Laboratory initiated a program to characterize selected aquatic biological populations to determine (1) existing levels of inorganic chemical and radionuclide contamination, and (2) the populations' suitability as indicators of chemical releases during cleanup activities at the US Department of Energy's Hanford Site. Following work plans for the ground-water operable units, lower trophic levels in the aquatic habitat (periphyton and caddisfly larvae) were evaluated for contaminants at the 100-HR-3 Operable Unit and 100-NR-1 Operable Unit. The results were evaluated to determine the need for further sampling. If the results showed no significant contamination compared to upriver levels, sampling would be discontinued. The periphyton community appears to be suitable for determining contamination levels. Baseline concentrations for stable chromium were established and will be useful for comparing samples collected when contaminant release is expected. Concentrations of 60 Co, 90 Sr, and 137 Cs in periphyton were essentially below detectable limits, which will also make this community useful in detecting potential releases of radionuclides during cleanup activities. Levels for both stable chromium and radionuclides were essentially below detection limits for caddisfly larvae. Thus, these organisms may be used to monitor suspected contaminant releases from cleanup activities; if concentrations exceed detection limits, they may be related to these activities. Two candidate threatened and endangered species of molluscs occur in the Hanford Reach of the Columbia River. These are the shortface lanx (Fisherola nuttalli), which is a Washington State candidate species, and the Columbia pebblesnail (Fluminicola columbiana), which is both a state and federal candidate species. Specimens of the shortface lanx were observed in the vicinity of N Springs (100-NR-1 Operable Unit); they likely occur throughout this area

She’s the Boss – HR och kvinnligt chefskap : Hur Human Resources kan arbeta för att främja kvinnorschefskarriärer

OpenAIRE

Linderfyhr, Jessica; Malm, Mikaela

2017-01-01

Enligt undersökningar som chefsorganisationen Ledarna publicerar årligen finns det en återkommande problematik med att rekrytera unga kvinnor till chefspositioner. Syftet med examensarbetet är att undersöka vad som kan inverka på kvinnors vilja att söka en chefstjänst och att utforma en HR strategi som främjar och motiverar kvinnor att söka chefstjänster. Unga kvinnor kan känna tvekan inför chefskap på grund av känslan av bristande erfarenhet och svårighet med att identifiera sig med den ster...

Role of endocortical contouring methods on precision of HR-pQCT-derived cortical micro-architecture in postmenopausal women and young adults.

Science.gov (United States)

Kawalilak, C E; Johnston, J D; Cooper, D M L; Olszynski, W P; Kontulainen, S A

2016-02-01

Precision errors of cortical bone micro-architecture from high-resolution peripheral quantitative computed tomography (pQCT) ranged from 1 to 16 % and did not differ between automatic or manually modified endocortical contour methods in postmenopausal women or young adults. In postmenopausal women, manually modified contours led to generally higher cortical bone properties when compared to the automated method. First, the objective of the study was to define in vivo precision errors (coefficient of variation root mean square (CV%RMS)) and least significant change (LSC) for cortical bone micro-architecture using two endocortical contouring methods: automatic (AUTO) and manually modified (MOD) in two groups (postmenopausal women and young adults) from high-resolution pQCT (HR-pQCT) scans. Second, it was to compare precision errors and bone outcomes obtained with both methods within and between groups. Using HR-pQCT, we scanned twice the distal radius and tibia of 34 postmenopausal women (mean age ± SD 74 ± 7 years) and 30 young adults (27 ± 9 years). Cortical micro-architecture was determined using AUTO and MOD contour methods. CV%RMS and LSC were calculated. Repeated measures and multivariate ANOVA were used to compare mean CV% and bone outcomes between the methods within and between the groups. Significance was accepted at P young adults, postmenopausal women had better precision for radial cortical porosity (precision difference 9.3 %) and pore volume (7.5 %) with MOD. Young adults had better precision for cortical thickness (0.8 %, MOD) and tibial cortical density (0.2 %, AUTO). In postmenopausal women, MOD resulted in 0.2-54 % higher values for most cortical outcomes, as well as 6-8 % lower radial and tibial cortical BMD and 2 % lower tibial cortical thickness. Results suggest that AUTO and MOD endocortical contour methods provide comparable repeatability. In postmenopausal women, manual modification of endocortical contours led to

ALMA 1.3 Millimeter Map of the HD 95086 System -- A Young Analog of the HR 8799 System

Science.gov (United States)

Su, Kate; MacGregor, Meredith Ann; Booth, Mark; Wilner, David; Malhotra, Renu; Morrison, Sarah; OST STDT

2018-01-01

Planets and minor bodies such as asteroids, Kuiper-belt objects and comets are integral components of a planetary system. Interactions among them leave clues about the formation process of a planetary system. The signature of such interactions is best illustrated through resolved observations of its debris disk. Here we present ALMA 1.3 mm observations of HD 95086, a young analog of the HR 8799 system, that hosts a directly imaged giant planet b and a massive debris disk with both asteroid- and Kuiper-belt analogs. The location of the Kuiper-belt analog is resolved for the first time. Our deep ALMA map also reveals a bright source located near the edge of the ring. The properties of the source, based on limited data, are consistent with it being a luminous star-forming galaxy at high redshift. We will discuss future, resolved observations of debris disks, highlighting the potential of the Origins Space Telescope (OST), one of the four science and technology definition studies commissioned by NASA Headquarters for the 2020 Astronomy and Astrophysics Decadal survey.

HrcQ is necessary for Xanthomonas oryzae pv. oryzae HR-induction in non-host tobacco and pathogenicity in host rice

Directory of Open Access Journals (Sweden)

Xiaoping Zhang

2013-12-01

Full Text Available Bacterial blight, caused by Xanthomonas oryzae pv. oryzae (Xoo, is one of the most destructive diseases of rice (Oryza sativa L. worldwide. The type III secretion system (T3SS of Xoo, encoded by the hrp (hypersensitive response and pathogenicity genes, plays critical roles in conferring pathogenicity in host rice and triggering a hypersensitive response (HR in non-host plants. To investigate the major genes conferring the pathogenicity and avirulence of Xoo, we previously constructed a random Tn5-insertion mutant library of Xoo strain PXO99A. We report here the isolation and characterization of a Tn5-insertion mutant PXM69. Tn5-insertion mutants were screened on indica rice JG30, which is highly susceptible to PXO99A, by leaf-cutting inoculation. Four mutants with reduced virulence were obtained after two rounds of screening. Among them, the mutant PXM69 had completely lost virulence to the rice host and ability to elicit HR in non-host tobacco. Southern blotting analysis showed a single copy of a Tn5-insertion in the genome of PXM69. PCR walking and sequencing analysis revealed that the Tn5 transposon was inserted at nucleotide position 70,192–70,201 in the genome of PXO99A, disrupting the type III hrc (hrp-conserved gene hrcQ, the first gene in the D operon of the hrp cluster in Xoo. To confirm the relationship between the Tn5-insertion and the avirulence phenotype of PXM69, we used the marker exchange mutagenesis to create a PXO99A mutant, ΔhrcQ::KAN, in which the hrcQ was disrupted by a kanamycin-encoding gene cassette at the same site as that of the Tn5-insertion. ΔhrcQ::KAN showed the same phenotype as mutant PXM69. Reintroduction of the wild-type hrcQ gene partially complemented the pathogenic function of PXM69. RT-PCR and cellulase secretion assays showed that the Tn5-disruption of hrcQ did not affect transcription of downstream genes in the D operon and function of the type II secretion system. Our results provide new insights into

HrcQ is necessary for Xanthomonas oryzae pv. oryzae HR-induction in non-host tobacco and pathogenicity in host rice

Institute of Scientific and Technical Information of China (English)

Xiaoping; Zhang; Chunlian; Wang; Chongke; Zheng; Jinying; Che; Yanqiang; Li; Kaijun; Zhao

2013-01-01

Bacterial blight, caused by Xanthomonas oryzae pv. oryzae(Xoo), is one of the most destructive diseases of rice(Oryza sativa L.) worldwide. The type III secretion system(T3SS) of Xoo, encoded by the hrp(hypersensitive response and pathogenicity) genes, plays critical roles in conferring pathogenicity in host rice and triggering a hypersensitive response(HR) in non-host plants. To investigate the major genes conferring the pathogenicity and avirulence of Xoo, we previously constructed a random Tn5-insertion mutant library of Xoo strain PXO99A. We report here the isolation and characterization of a Tn5-insertion mutant PXM69. Tn5-insertion mutants were screened on indica rice JG30, which is highly susceptible to PXO99A, by leaf-cutting inoculation.Four mutants with reduced virulence were obtained after two rounds of screening. Among them, the mutant PXM69 had completely lost virulence to the rice host and ability to elicit HR in non-host tobacco. Southern blotting analysis showed a single copy of a Tn5-insertion in the genome of PXM69. PCR walking and sequencing analysis revealed that the Tn5 transposon was inserted at nucleotide position 70,192–70,201 in the genome of PXO99A, disrupting the type III hrc(hrp-conserved) gene hrcQ, the first gene in the D operon of the hrp cluster in Xoo. To confirm the relationship between the Tn5-insertion and the avirulence phenotype of PXM69, we used the marker exchange mutagenesis to create a PXO99Amutant, ΔhrcQ::KAN, in which the hrcQ was disrupted by a kanamycin-encoding gene cassette at the same site as that of the Tn5-insertion. ΔhrcQ::KAN showed the same phenotype as mutant PXM69. Reintroduction of the wild-type hrcQ gene partially complemented the pathogenic function of PXM69. RT-PCR and cellulase secretion assays showed that the Tn5-disruption of hrcQ did not affect transcription of downstream genes in the D operon and function of the type II secretion system. Our results provide new insights into the pathogenic

Conceptual site models for groundwater contamination at 100-BC-5, 100-KR-4, 100-HR-3, and 100-FR-3 operable units

International Nuclear Information System (INIS)

Peterson, R.E.; Raidl, R.F.; Denslow, C.W.

1996-09-01

This document presents technical information on groundwater contamination in the 100-BC-5, 100-KR-4, 100-HR-3, and 100-FR-3 Operable Units on the Hanford Site in Richland, Washington. These operable units are defined for groundwater that underlies the retired plutonium production reactors and their associated support facilities. This technical information supports conceptual site models (CSM) for each operable unit. The goal in maintaining a CSM is to ensure that a reasonable understanding of contamination issues in each groundwater operable unit is available for selecting a final remediation alternative and for developing a record of decision. CSMs are developed for hazardous waste sites to help evaluate potential risks to human health and the environment from exposure to contamination

H.R. 1020: A Bill to amend the Nuclear Waste Policy Act of 1982. Introduced in the House of Representatives, One Hundred Fourth Congress, First Session, February 23, 1995

International Nuclear Information System (INIS)

Anon.

1995-01-01

The report H.R. 1020 is a bill to amend the Nuclear Waste Policy Act of 1982. The purpose of the Act is to direct the Secretary of Energy to develop an integrated spent nuclear fuel management system and to commence acceptance of spent nuclear fuel and high-level radioactive waste in accordance with the acceptable schedule no later than January 31, 1998. The proposed legislative text is included

Correlation of different types of emphysema in high-resolution computed tomography (HR-CT) with the ILO-classification of coal workers pneumoconiosis

International Nuclear Information System (INIS)

Eibel, R.; Weber, A.; Stolpe, S.; Hellenbrand, U.; Bauer, T.

2002-01-01

Purpose: The complaints of patients suffering from pneumoconiosis and the decrease in cardio-respiratory function tests are related to the major complications, emphysema or bronchitis, resp. to a lesser degree the complaints are directly influenced by the silicotic process itself. Up to now, no large study has analysed the correlation of different types and severity of emphysema with the ILO-classification of pneumoconiosis in miners. Material and Methods: In 104 miners the severity of pneumoconiosis was classified by ILO. By HR-CT the type and severity of emphysema was analysed using a 4-point-scale. The correlation of emphysema with the ILO-classification was tested with Pearson-correlation. Results: The centrolobular emphysema was the dominant type with 59%, but there was no dependence on the severity of pneumoconiosis. Only the paracicatricial emphysema had a significant correlation (p [de

Comparative effectiveness of everolimus-based therapy versus endocrine monotherapy among postmenopausal women with HR+/HER2- metastatic breast cancer: a retrospective chart review in community oncology practices in the US.

Science.gov (United States)

Xie, Jipan; Hao, Yanni; Li, Nanxin; Lin, Peggy L; Ohashi, Erika; Koo, Valerie; Signorovitch, James E; Wu, Eric Q; Yardley, Denise A

2015-06-01

Everolimus-based therapy and endocrine monotherapy are used among postmenopausal women with hormone receptor-positive human epidermal growth factor receptor-2 negative (HR+/HER2-) metastatic breast cancer (mBC) whose disease progressed or recurred on a non-steroidal aromatase inhibitor (NSAI). However, limited evidence exists regarding the real-world comparative effectiveness of these agents. This retrospective chart review examined postmenopausal HR+/HER2- mBC patients in community-based oncology practices who received everolimus-based therapy or endocrine monotherapy (index therapy) as any line of therapy for mBC between 1 July 2012 and 15 April 2013 after NSAI failure. Time on treatment (TOT), progression-free survival (PFS), and time to chemotherapy (TTC) from index therapy initiation were compared using Kaplan-Meier analyses and Cox proportional hazards models adjusting for baseline characteristics. A total of 243 and 270 patients received everolimus-based therapy or endocrine monotherapy in a quota-based sample. Patients treated with everolimus-based therapy had a higher proportion of visceral metastases, high tumor burden, and use of prior chemotherapies for mBC. After adjusting for baseline characteristics, everolimus-based therapy was associated with significantly longer TOT (HR = 0.67, 95% CI: 0.51-0.87) and PFS (HR = 0.75, 95% CI: 0.57-0.98) than endocrine monotherapy. No significant difference was found between everolimus-based therapy and endocrine monotherapy in TTC (HR = 0.81, 95% CI: 0.52-1.27). Results stratified by line of therapy were generally consistent with the overall results. Limitations include recall and information bias with potentially absent or erroneous chart data, unobserved factors due to non-randomization, inability to measure outcome assessments paired with measuring outcomes prior to exposures, and potential patient selection bias associated with chart review. Among a nationwide sample of postmenopausal HR+/HER2- m

Evaluation of the ECAT EXACT HR+ 3D PET scanner in 15O-water brain activation studies

International Nuclear Information System (INIS)

Moreno-Cantu, J.J.; Thompson, C.J.; Zatorre, R.J.

1996-01-01

We evaluated the performance of the ECAT EXACT HR + 3D whole body PET scanner when employed to measure brain function using 15 O-water-bolus activation protocols in single data acquisition sessions. Using vibrotactile and auditory stimuli as independent activation tasks, we studied the scanner's performance under different imaging conditions in four healthy volunteers. Cerebral blood flow images were acquired from each volunteer using 15 O-water-bolus injections of activity varying from 5 to 20mCi. Performance characteristics. The scanner's dead time grew linearly with injected dose from 10% to 25%. Random events varied from 30% to 50% of the detected events. Scattered events were efficiently corrected at all doses. Noise-effective-count curves plateau at about 15mCi. One-session 12-injection bolus PET activation protocol. Using an acquisition protocol that accounts for the scanner's performance and the practical aspects of imaging volunteers and patients in one session, we assessed the correlation between the statistical significance of activation foci and the dose per injection used The one-session protocol employs 12 bolus injections per subject. We present evidence suggesting that 15-20mCi is the optimal dose per injection to be used routinely in one-time scanning sessions

Biodistribution of 99mTc-labeled anti-human epidermal growth factor receptor (EGF-R) humanized monoclonal antibody h-R3 in a xenograft model of human lung adenocarcinoma

International Nuclear Information System (INIS)

Morales-Morales, Alejo; Duconge, Jorge; Caballero-Torres, Idania; Nunez-Gandolff, Gilda; Fernandez, Eduardo; Iznaga-Escobar, Normando

1999-01-01

The anti-human epidermal growth factor receptor (EGF-R) humanized monoclonal antibody (MAb) h-R3 is an (IgG 1 ), which binds to an extracellular domain of EGF-R. It was used to evaluate the biodistribution on nude mice xenografted with H-125 human lung adenocarcinoma cell line. Results were compared with its murine version of the MAb ior-egf/r3. Twenty-one athymic female 4NMRI nu/nu mice were injected intraperitoneally with 10 μg/100 μCi of 99m Tc-labeled MAbs. Immunoreactivity of 99m Tc-labeled MAbs were measured by enzyme-linked immunosorbent assay (ELISA) on H-125 cell line and the immunoreactive fractions was determined by the Lindmo method. Among all organs, significant accumulation was found in serum (27.05 ± 2.08 %ID/g) and tumor (3.903 ± 0.89 %ID/g) at 4 h after injection. These values decreased to 5.03 ± 0.50 %ID/g and 2.19 ± 0.56 %ID/g for serum and tumor, respectively. The immunoreactive fraction was found to be 0.70, with a correlation coefficient r=0.9984. With the good biodistribution and tumor uptake of the 99m Tc-labeled humanized antibody h-R3, a phase I diagnostic clinical trial of tumor with epithelial origin should be pursued

GROUDWATER REMEDIATION AT THE 100-HR-3 OPERABLE UNIT HANFORD, SITE WASHINGTON, USA - 11507

International Nuclear Information System (INIS)

Smoot, J.L.; Biebesheimer, F.H.; Eluskie, J.A.; Spiliotopoulos, A.; Tonkin, M.J.; Simpkin, T.

2011-01-01

The 100-HR-3 Groundwater Operable Unit (OU) at the Hanford Site underlies three former plutonium production reactors and the associated infrastructure at the 100-D and 100-H Areas. The primary contaminant of concern at the site is hexavalent chromium; the secondary contaminants are strontium-90, technetium-99, tritium, uranium, and nitrate. The hexavalent chromium plume is the largest plume of its type in the state of Washington, covering an area of approximately 7 km 2 (2.7 mi 2 ) with concentrations greater than 20 (micro)g/L. Concentrations range from 60,000 (micro)g/L near the former dichromate transfer station in the 100-D Area to large areas of 20 to 100 (micro)g/L across much of the plume area. Pump-and-treat operations began in 1997 and continued into 2010 at a limited scale of approximately 200 gal/min. Remediation of groundwater has been fairly successful in reaching remedial action objectives (RAOs) of 20 (micro)g/L over a limited region at the 100-H, but less effective at 100-D. In 2000, an in situ, permeable reactive barrier was installed downgradient of the hotspot in 100-D as a second remedy. The RAOs are still being exceeded over a large portion of the area. The CH2M HILL Plateau Remediation Company was awarded the remediation contract for groundwater in 2008 and initiated a remedial process optimization study consisting of modeling and technical studies intended to enhance the remediation. As a result of the study, 1,400 gal/min of expanded treatment capacity are being implemented. These new systems are designed to meet 2012 and 2020 target milestones for protection of the Columbia River and cleanup of the groundwater plumes.

Nové trendy ve využívání kulturních památek na příkladu Hrádku u Nechanic

OpenAIRE

Dobřenská, Lucie

2011-01-01

This Master thesis focuses on trends in utilization of castles and chateaus accessible to public within tourism and further applies the acquired knowledge to the Hrádek u Nechanic chateau. In order to reach the objective, a combination of primary and secondary research has been employed. The first part of the thesis (chapters 1--3) deals with general trends in tourism, cultural tourism, utilization of castles and chateaus in general and, in particular, it identifies the main qualitative and q...

Study on in vivo examination of tumors of epithelial origin for the monoclonales antibodies ior c5, ior egf/r3 and humanized hr3, by using inmunogammagraphy technique

International Nuclear Information System (INIS)

Ramos Suzarte, Mayra; Iznaga Escobar, Normando; Torres Gemil, Olga; Rodriguez Obaya, Teresita; Perez Rodriguez, Rolando; Rodriguez Mesa, Nelson; Oliva Gonzalez, Juan P.; Perera Pintado, Alejandro; Torres Aroche, Leonel; Batista Cuellar, Juan; Gonzalez Lazo, Nery; Cruz, Teresa; Leonard, Ibrahim; Neninger, Elia

2003-01-01

The present work is aimed at demonstrating that humanized hR3 and ior egf/r3, ior c5, ior cea-1 murine monoclonal antibodies (mAbs) can identify primary neoplasia lesions, Their post-surgical received and metastasis by using immunography, Results showed that above mentioned mAbs are useful for the diagnosis of epithelial tumors, their metastasis and post-surgical received. this technique becomes a concept prove for further use of mAbs in cancer therapy

LC-HR-MS/MS standard urine screening approach: Pros and cons of automated on-line extraction by turbulent flow chromatography versus dilute-and-shoot and comparison with established urine precipitation.

Science.gov (United States)

Helfer, Andreas G; Michely, Julian A; Weber, Armin A; Meyer, Markus R; Maurer, Hans H

2017-02-01

Comprehensive urine screening for drugs and metabolites by LC-HR-MS/MS using Orbitrap technology has been described with precipitation as simple workup. In order to fasten, automate, and/or simplify the workup, on-line extraction by turbulent flow chromatography and a dilute-and-shoot approach were developed and compared. After chromatographic separation within 10min, the Q-Exactive mass spectrometer was run in full scan mode with positive/negative switching and subsequent data dependent acquisition mode. The workup approaches were validated concerning selectivity, recovery, matrix effects, process efficiency, and limits of identification and detection for typical drug representatives and metabolites. The total workup time for on-line extraction was 6min, for the dilution approach 3min. For comparison, the established urine precipitation and evaporation lasted 10min. The validation results were acceptable. The limits for on-line extraction were comparable with those described for precipitation, but lower than for dilution. Thanks to the high sensitivity of the LC-HR-MS/MS system, all three workup approaches were sufficient for comprehensive urine screening and allowed fast, reliable, and reproducible detection of cardiovascular drugs, drugs of abuse, and other CNS acting drugs after common doses. Copyright © 2016 Elsevier B.V. All rights reserved.

Capturing specific abilities as a window into human individuality: the example of face recognition.

Science.gov (United States)

Wilmer, Jeremy B; Germine, Laura; Chabris, Christopher F; Chatterjee, Garga; Gerbasi, Margaret; Nakayama, Ken

2012-01-01

Proper characterization of each individual's unique pattern of strengths and weaknesses requires good measures of diverse abilities. Here, we advocate combining our growing understanding of neural and cognitive mechanisms with modern psychometric methods in a renewed effort to capture human individuality through a consideration of specific abilities. We articulate five criteria for the isolation and measurement of specific abilities, then apply these criteria to face recognition. We cleanly dissociate face recognition from more general visual and verbal recognition. This dissociation stretches across ability as well as disability, suggesting that specific developmental face recognition deficits are a special case of a broader specificity that spans the entire spectrum of human face recognition performance. Item-by-item results from 1,471 web-tested participants, included as supplementary information, fuel item analyses, validation, norming, and item response theory (IRT) analyses of our three tests: (a) the widely used Cambridge Face Memory Test (CFMT); (b) an Abstract Art Memory Test (AAMT), and (c) a Verbal Paired-Associates Memory Test (VPMT). The availability of this data set provides a solid foundation for interpreting future scores on these tests. We argue that the allied fields of experimental psychology, cognitive neuroscience, and vision science could fuel the discovery of additional specific abilities to add to face recognition, thereby providing new perspectives on human individuality.

Biodistribution of {sup 99m}Tc-labeled anti-human epidermal growth factor receptor (EGF-R) humanized monoclonal antibody h-R3 in a xenograft model of human lung adenocarcinoma

Energy Technology Data Exchange (ETDEWEB)

Morales-Morales, Alejo; Duconge, Jorge; Caballero-Torres, Idania; Nunez-Gandolff, Gilda; Fernandez, Eduardo; Iznaga-Escobar, Normando E-mail: normando@ict.cim.sld.cu

1999-04-01

The anti-human epidermal growth factor receptor (EGF-R) humanized monoclonal antibody (MAb) h-R3 is an (IgG{sub 1}), which binds to an extracellular domain of EGF-R. It was used to evaluate the biodistribution on nude mice xenografted with H-125 human lung adenocarcinoma cell line. Results were compared with its murine version of the MAb ior-egf/r3. Twenty-one athymic female 4NMRI nu/nu mice were injected intraperitoneally with 10 {mu}g/100 {mu}Ci of {sup 99m}Tc-labeled MAbs. Immunoreactivity of {sup 99m}Tc-labeled MAbs were measured by enzyme-linked immunosorbent assay (ELISA) on H-125 cell line and the immunoreactive fractions was determined by the Lindmo method. Among all organs, significant accumulation was found in serum (27.05 {+-} 2.08 %ID/g) and tumor (3.903 {+-} 0.89 %ID/g) at 4 h after injection. These values decreased to 5.03 {+-} 0.50 %ID/g and 2.19 {+-} 0.56 %ID/g for serum and tumor, respectively. The immunoreactive fraction was found to be 0.70, with a correlation coefficient r=0.9984. With the good biodistribution and tumor uptake of the {sup 99m}Tc-labeled humanized antibody h-R3, a phase I diagnostic clinical trial of tumor with epithelial origin should be pursued.

Controlling HR Costs.

Science.gov (United States)

Ellig, Bruce R.

1990-01-01

Controlling human resources costs is critical for a competitive advantage. More money will have to be invested in education and training because of an inadequate, ill-prepared group of entry-level workers. Commitment to employees will have to be considered in relation to the increased investment in them. (JOW)

HR Public meeting

CERN Multimedia

CERN. Geneva

2010-01-01

Chef du Département des Ressources humaines *Cette réunion sera retransmise simultanément dans l’Amphithéâtre BE de Prévessin (Bâtiment 864) et également disponible à l’adresse suivante : http://webcast.cern.ch -------------------------------------------------------- ...

Retracted article: Flexible Fourier Stationary Test in GDP per capita for Central Eastern European Countries

Directory of Open Access Journals (Sweden)

Meng-Nan Zhu

2011-06-01

Full Text Available Statement of Retraction (http://www.efri.uniri.hr/prikaz.asp?txt_id=7366 This is to notify our respectful reading public that the Editorial Board of the journal Zbornik radova Ekonomskog fakulteta u Rijeci, časopis za ekonomsku teoriju i praksu/ Proceedings of Rijeka Faculty of Economics, Journal of Economics and Business has retracted the following article from publication: “Flexible Fourier Stationary Test in GDP per capita for Central Eastern European Countries“, by Hsu-Ling Chang, Chi-Wei Su, Meng-Nan Zhu, published in our journal Zbornik radova Ekonomskog fakulteta u Rijeci, časopis za ekonomsku teoriju i praksu/ Proceedings of Rijeka Faculty of Economics, Journal of Economics and Business, 2011, vol. 29 (1, pp. 51-63 and almost concurrently published in the journal Eastern European Economics, 2011, vol. 49 (3, pp. 54-65. Being in contact with Josef C Brada, Professor Emeritus, Editor of the journal Eastern European Economics (EEE, we realized that the paper had been sent to both journals, although first published in the EEE and then in our Journal. According to professor Brada’s and our analysis, the paper published in these two journals is exactly the same, except for minor differences in wording, most likely due to editing the text before publication. The outstanding differences are in the title and the fact that the paper published in our Journal has three authors and in EEE journal has two. Whatsoever, owing to the fact that the article had been sent to both journals almost at the same time, it had been impossible to find out the case during the review procedure. Due to this unpleasant situation, our Editorial Board would like to inform our valuable readers that all the necessary measures to retract the paper from our publication have been undertaken and according to publishing ethical principles, cooperation with the authors of the retracted paper have been stopped. Although, in this case neither EEE nor our Journal had any

The gas-rich circumbinary disk of HR 4049. I. A detailed study of the mid-infrared spectrum

Energy Technology Data Exchange (ETDEWEB)

Malek, S. E.; Cami, J., E-mail: sarahemalek@gmail.com, E-mail: jcami@uwo.ca [Department of Physics and Astronomy, University of Western Ontario, London, ON N6A 3K7 (Canada)

2014-01-01

We present a detailed analysis of the mid-infrared spectrum of the peculiar evolved object HR 4049. The full Spitzer-IRS high-resolution spectrum shows a wealth of emission with prominent features from CO{sub 2} and H{sub 2}O and possible contributions from HCN and OH. We model the molecular emission and find that it originates from a massive (M ≳ 8 × 10{sup –3} M {sub ☉}), warm (T {sub ex} ≈ 500 K) and radially extended gas disk that is optically thick at infrared wavelengths. We also report less enrichment in {sup 17}O and {sup 18}O than previously found and a comparison of the Spitzer observations to earlier data obtained by the Short Wavelength Spectrometer on board the Infrared Space Observatory reveals that the CO{sub 2} flux has more than doubled in 10 yr time, indicating active and ongoing chemical evolution in the circumbinary disk. If the gas originates from interaction between the stellar wind and the dust, this suggests that the dust could be oxygen-rich in nature. The molecular gas plays a crucial role in the thermal properties of the circumbinary disk by allowing visible light to heat the dust and then trapping the infrared photons emitted by the dust. This results in higher temperatures and a more homogeneous temperature structure in the disk.

Folding of non-Euclidean curved shells

Science.gov (United States)

Bende, Nakul; Evans, Arthur; Innes-Gold, Sarah; Marin, Luis; Cohen, Itai; Santangelo, Christian; Hayward, Ryan

2015-03-01

Origami-based folding of 2D sheets has been of recent interest for a variety of applications ranging from deployable structures to self-folding robots. Though folding of planar sheets follows well-established principles, folding of curved shells involves an added level of complexity due to the inherent influence of curvature on mechanics. In this study, we use principles from differential geometry and thin shell mechanics to establish fundamental rules that govern folding of prototypical creased shells. In particular, we show how the normal curvature of a crease line controls whether the deformation is smooth or discontinuous, and investigate the influence of shell thickness and boundary conditions. We show that snap-folding of shells provides a route to rapid actuation on time-scales dictated by the speed of sound. The simple geometric design principles developed can be applied at any length-scale, offering potential for bio-inspired soft actuators for tunable optics, microfluidics, and robotics. This work was funded by the National Science Foundation through EFRI ODISSEI-1240441 with additional support to S.I.-G. through the UMass MRSEC DMR-0820506 REU program.

Insights into Inverse Materials Design from Phase Transitions in Shape Space

Science.gov (United States)

Cersonsky, Rose; van Anders, Greg; Dodd, Paul M.; Glotzer, Sharon C.

In designing new materials for synthesis, the inverse materials design approach posits that, given a structure, we can predict a building block optimized for self- assembly. How does that building block change as pressure is varied to maintain the same crystal structure? We address this question for entropically stabilized colloidal crystals by working in a generalized statistical thermodynamic ensemble where an alchemical potential variable is fixed and its conjugate variable, particle shape, is allowed to fluctuate. We show that there are multiple regions of shape behavior and phase transitions in shape space between these regions. Furthermore, while past literature has looked towards packing arguments for proposing shape-filling candidate building blocks for structure formation, we show that even at very high pressures, a structure will attain lowest free energy by modifying these space-filling shapes. U.S. Army Research Office under Grant Award No. W911NF-10-1-0518, Emerging Frontiers in Research and Innovation Award EFRI-1240264, National Science Foundation Grant Number ACI- 1053575, XSEDE award DMR 140129, Rackham Merit Fellowship Program.

Observation of anomalous Stokes versus anti-Stokes ratio in MoTe2 atomic layers

Science.gov (United States)

Goldstein, Thomas; Chen, Shao-Yu; Xiao, Di; Ramasubramaniam, Ashwin; Yan, Jun

We grow hexagonal molybdenum ditelluride (MoTe2), a prototypical transition metal dichalcogenide (TMDC) semiconductor, with chemical vapor transport methods and investigate its atomic layers with Stokes and anti-Stokes Raman scattering. We report observation of all six types of zone center optical phonons. Quite remarkably, the anti-Stokes Raman intensity of the low energy layer-breathing mode becomes more intense than the Stokes peak under certain experimental conditions, creating an illusion of 'negative temperature'. This effect is tunable, and can be switched from anti-Stokes enhancement to suppression by varying the excitation wavelength. We interpret this observation to be a result of resonance effects arising from the C excitons in the vicinity of the Brillouin zone center, which are robust even for multiple layers of MoTe2. The intense anti-Stokes Raman scattering provides a cooling channel for the crystal and opens up opportunities for laser cooling of atomically thin TMDC semiconductor devices. Supported by the University of Massachusetts Amherst, the National Science Foundation Center for Hierarchical Manufacturing (CMMI-1025020) and Office of Emerging Frontiers in Research and Innovation (EFRI-1433496).

Federal Employee Family-Building Act of 1987. Hearing on H.R. 2852 before the Subcommittee on Civil Service of the Committee on Post Office and Civil Service. House of Representatives, One Hundredth Congress, First Session.

Science.gov (United States)

Congress of the U. S., Washington, DC. House Committee on Post Office and Civil Service.

A hearing was held to consider H.R. 2852, the Federal Employee Family-Building Act, a proposal that would require health insurance plans for federal employees to cover the costs of adoption and fertility treatments. Testimony concerned: (1) difficulties childless and infertile federal employees encountered in efforts to adopt and conceive…

Cost Reduction and Business Strategy Matters to Human Resource Outsourcing? A Validation by HR Experts from Government Link Companies (GLC’s.

Directory of Open Access Journals (Sweden)

Mansor Mohd Fitri

2018-01-01

Full Text Available The phenomenon of outsourcing has spawned a rich body scholarly reseach in sveral decades. However, the answer to one of the pertinent question has remained elusive: Does cost reduction and business strategy really matters to the human resource outsourcing impacts. Looking at this question it is important for the organization to embark on the practice of human resource outsourcing to save operating cost and remain competitive. Therefore, the objective of this study is to investigate the effects of cost reduction and business starategy towards human resource outsourcing impacts. Both quantitative and qualitative methods were employed and the top management in Malaysian Government Link Companies (GLC’ is the unit of analysis. The findings revelaved that, both variables are significant statistically and non statically i.e from the experts opinion. Finally, the study also provides useful directions for future research, HR Practitioners and policy maker particularly in managing and organizing human reseouce matters.

The effectiveness of osteopathic manipulative treatment in an abnormal uterine bleeding related pain and health related quality of life (HR-QoL) - A case report.

Science.gov (United States)

Goyal, Kanu; Goyal, Manu; Narkeesh, Kanimozhi; John Samuel, Asir; Sharma, Sorabh; Chatterjee, Subhasish; Arumugam, Narkeesh

2017-07-01

Abnormal uterine bleeding is characterized by painful and/or excessive menorrhea, chronic pelvic pain due to the endometriosis (Em). Osteopathic treatment is commonly used in the gynecological dysfunctions. The aim of the present case study was to explore the effect of osteopathic treatment (OT) for a woman with abnormal uterine bleeding related pain and quality of life (QoL). We reported a case of 29 year old female who presented with chief complaints of increased flow during periods, lower abdominal pain, leukorrhoea, lower back pain and with occasional constipation for the last 3 years. Patient is a mother of 6 years old male child born with normal delivery. On diagnostic ultrasonography the uterus was found bulky with insignificant endometriosis and no other abnormality was detected. She did not have any relevant past medical and surgical history. The pre and post osteopathic treatment measurements were measured using Visual Analog Scale (VAS) and the health related quality of life (HR-QoL) questionnaire called short form Endometriosis Health Profile Questionnaire (EHP) - 5. In the present case the pain due to the endometriosis was treated with the osteopathic treatment consists of all the major diaphragms' release (release of pelvic diaphragm, abdominal diaphragm, thoracic outlet release and hyoid diaphragm) during the first session and in the second session gastro-esophageal (GE) junction release, sigmoid colon release, cranial therapy to the occiput, sacral release and dural tube rocking. Following that improvement of pain from VAS 8.3/10 to 3.9/10 and QoL improvement from EHP-5, 72/100 to 26/100 was noted. Osteopathic manipulative approach (OMA) in the patient with Em might improve the abnormal uterine bleeding related pain and health related quality of life (HR-QoL). Copyright © 2016 Elsevier Ltd. All rights reserved.

Enhanced H-filter based on Fåhræus-Lindqvist effect for efficient and robust dialysis without membrane.

Science.gov (United States)

Zheng, Wei-Chao; Xie, Rui; He, Li-Qun; Xi, Yue-Heng; Liu, Ying-Mei; Meng, Zhi-Jun; Wang, Wei; Ju, Xiao-Jie; Chen, Gang; Chu, Liang-Yin

2015-07-01

A novel microfluidic device for highly efficient and robust dialysis without membrane is highly desired for the development of portable or wearable microdialyzer. Here we report an enhanced H-filter with pillar array based on Fåhræus-Lindqvist effect (F-L effect) for highly efficient and robust membraneless dialysis of simplified blood for the first time. The H-filter employs two fluids laminarly flowing in the microchannel for continuously membraneless dialysis. With pillar array in the microchannel, the two laminar flows, with one containing blood cells and small molecules and another containing dialyzate solution, can form a cell-free layer at the interface as selective zones for separation. This provides enhanced mixing yet extremely low shear for extraction of small molecules from the blood-cell-containing flow into the dialyzate flow, resulting in robust separation with reduced cell loss and improved efficiency. We demonstrate this by first using Chlorella pyrenoidosa as model cells to quantitatively study the separation performances, and then using simplified human blood for dialysis. The advanced H-filter, with highly efficient and robust performance for membraneless dialysis, shows great potential as promising candidate for rapid blood analysis/separation, and as fundamental structure for portable dialyzer.

Time-series photometric spot modeling. 2: Fifteen years of photometry of the bright RS CVn binary HR 7275

Science.gov (United States)

Strassmeier, K. G.; Hall, D. S.; Henry, G. W.

1994-01-01

We present a time-dependent spot modeling analysis of 15 consecutive years of V-band photometry of the long-period (P(sub orb) = 28.6 days) RS CVn binary HR 7275. This baseline in time is one of the longest, uninterrupted intervals a spotted star has been observed. The spot modeling analysis yields a total of 20 different spots throughout the time span of our observations. The distribution of the observed spot migration rates is consistent with solar-type differential rotation and suggests a lower limit of the differential-rotation coefficient of 0.022 +/-0.004. The observed, maximum lifetime of a single spot (or spot group) is 4.5 years, the minimum lifetime is approximately one year, but an average spot lives for 2.2 years. If we assume that the mechanical shear by differential rotation sets the upper limit to the spot lifetime, the observed maximum lifetime in turn sets an upper limit to the differential-rotation coefficient, namely 0.04 +/- 0.01. This would be differential rotation just 5 to 8 times less than the solar value and one of the strongest among active binaries. We found no conclusive evidence for the existence of a periodic phenomenon that could be attributed to a stellar magnetic cycle.

Food irradiation. Hearing before the Subcommittee on Health and the Environment of the Committee on Energy and Commerce, House of Representatives, One Hundredth Congress, First Session on H.R. 956, June 19, 1987

International Nuclear Information System (INIS)

Anon.

1988-01-01

Government officials and representatives from health and food service groups were among those testifying on H.R. 956, the Food Irradiation Safety and Labeling Requirement Act of 1987. The area of most concern was to evaluate the actions of the Food and Drug Administration in approving the use of food irradiation technology and to discuss whether the FDA decision was the right one

Freie Lerninhalte im Internet mit Studierenden recherchieren, kommentieren und kompilieren. Zur Gestaltung der online-Selbstlernangebote im hr-Funkkolleg Philosophie

Directory of Open Access Journals (Sweden)

Jakob Krebs

2017-03-01

Full Text Available Wie lassen sich online frei verfügbare Bildungsinhalte mit Studierenden so zusammenstellen, dass sie als thematisch sortierte Selbstlernmaterialien unkompliziert gefunden werden können – sei es von anderen Studierenden, interessierten Laien oder auch von Lehrkräften in Bildungsinstitutionen? Der vorliegende Werkstattbericht rekonstruiert ein Lernszenario, in dem Studierende vorhandene Materialien im Internet recherchierten, kommentierten und kompilierten, um ein Online-Zusatzangebot zu den Radiosendungen im hr-Funkkolleg Philosophie 2014/15 zu erstellen. Die Rahmenbedingungen dieser ungewöhnlichen universitären Kooperation mit dem Rundfunk werden im ersten Abschnitt vorgestellt. Der zweite Abschnitt skizziert das didaktische Design zusammen mit dem Projektstrukturplan eines produktorientierten kollaborativen Lernsettings mit Wiki-Einsatz. Im dritten Abschnitt werden der Lernerfolg bei den Studierenden sowie einige Herausforderungen benannt, die u. a. in der Abschlussevaluierung zur Sprache kamen. Der vierte Abschnitt macht die Projekterfahrungen für reguläre Lehr- und Lern-Szenarien fruchtbar, in denen nicht nur Studierende mit didaktischen Interessen durch die gemeinsame Gestaltung von Internetangeboten fachlich und methodisch profitieren können. Mit dem Bericht wird somit u. a. veranschaulicht, wie sich Ansätze von Blended, Peer-Assisted und Service Learning produktiv kombinieren lassen.

Comparison of medical costs and healthcare resource utilization of post-menopausal women with HR+/HER2- metastatic breast cancer receiving everolimus-based therapy or chemotherapy: a retrospective claims database analysis.

Science.gov (United States)

Li, Nanxin; Hao, Yanni; Koo, Valerie; Fang, Anna; Peeples, Miranda; Kageleiry, Andrew; Wu, Eric Q; Guérin, Annie

2016-01-01

To analyze medical costs and healthcare resource utilization (HRU) associated with everolimus-based therapy or chemotherapy among post-menopausal women with hormone-receptor-positive, human-epidermal-growth-factor-receptor-2-negative (HR+/HER2-) metastatic breast cancer (mBC). Patients with HR+/HER2- mBC who discontinued a non-steroidal aromatase inhibitor and began a new line of treatment with everolimus-based therapy or chemotherapy (index therapy/index date) between July 20, 2012 and April 30, 2014 were identified from two large claims databases. All-cause, BC-related, and adverse event (AE)-related medical costs (in 2014 USD) and all-cause HRU per patient per month (PPPM) were analyzed for both treatment groups across patients' first four lines of therapies for mBC. Adjusted differences in costs and HRU between the everolimus and chemotherapy treatment group were estimated pooling all lines and using multivariable generalized linear models, accounting for difference in patient characteristics. A total of 3298 patients were included: 902 everolimus-treated patients and 2636 chemotherapy-treated patients. Compared to chemotherapy, everolimus was associated with significantly lower all-cause (adjusted mean difference = $3455, p well as significantly lower HRU (emergency room incidence rate ratio [IRR] = 0.83; inpatient IRR = 0.74; inpatient days IRR = 0.65; outpatient IRR = 0.71; BC-related outpatient IRR = 0.57; all p chemotherapy.

HR Del REMNANT ANATOMY USING TWO-DIMENSIONAL SPECTRAL DATA AND THREE-DIMENSIONAL PHOTOIONIZATION SHELL MODELS

International Nuclear Information System (INIS)

Moraes, Manoel; Diaz, Marcos

2009-01-01

The HR Del nova remnant was observed with the IFU-GMOS at Gemini North. The spatially resolved spectral data cube was used in the kinematic, morphological, and abundance analysis of the ejecta. The line maps show a very clumpy shell with two main symmetric structures. The first one is the outer part of the shell seen in Hα, which forms two rings projected in the sky plane. These ring structures correspond to a closed hourglass shape, first proposed by Harman and O'Brien. The equatorial emission enhancement is caused by the superimposed hourglass structures in the line of sight. The second structure seen only in the [O III] and [N II] maps is located along the polar directions inside the hourglass structure. Abundance gradients between the polar caps and equatorial region were not found. However, the outer part of the shell seems to be less abundant in oxygen and nitrogen than the inner regions. Detailed 2.5-dimensional photoionization modeling of the three-dimensional shell was performed using the mass distribution inferred from the observations and the presence of mass clumps. The resulting model grids are used to constrain the physical properties of the shell as well as the central ionizing source. A sequence of three-dimensional clumpy models including a disk-shaped ionization source is able to reproduce the ionization gradients between polar and equatorial regions of the shell. Differences between shell axial ratios in different lines can also be explained by aspherical illumination. A total shell mass of 9 x 10 -4 M sun is derived from these models. We estimate that 50%-70% of the shell mass is contained in neutral clumps with density contrast up to a factor of 30.

Proposed plan for interim remedial measures at the 100-HR-1 Operable Unit, Hanford Site, Richland, Washington

International Nuclear Information System (INIS)

1995-01-01

This proposed plan identifies the preferred alternative for interim remedial measures for remedial action of radioactive liquid waste disposal sites at the 100-HR-1 Operable Unit, located at the Hanford Site. It also summarizes other remedial alternatives evaluated for interim remedial measures in this operable unit. The intent of interim remedial measures is to speed up actions to address contaminated areas that historically received radioactive liquid waste discharges that pose a potential threat to human health and the environment. This proposed plan is being issued by the Washington State Department of Ecology (Ecology), the lead regulatory agency; the US Environmental Protection Agency (EPA), the support regulatory agency; and the US Department of Energy (DOE), the responsible agency. Ecology, EPA, and DOE are issuing this proposed plan as part of their public participation responsibilities under Section 117(a) of the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA), commonly known as the ''Superfund Program.'' The proposed plan is intended to be a fact sheet for public review that (1) briefly describes the remedial alternatives analyzed; (2) proposes a preferred alternative; (3) summarizes the information relied upon to recommend the preferred alternative; and (4) provides a basis for an interim action record of decision (ROD). The preferred alternative presented in this proposed plan is removal, treatment (as appropriate), and disposal of contaminated soil and associated structures. Treatment will be conducted if there is cost benefit

H.R. 3184: The Act may be cited as the Department of Energy Minority Economic Impact Revitalization Act. Introduced in the House of Representatives, One Hundredth Congress, First Session, August 4, 1989

International Nuclear Information System (INIS)

Anon.

1989-01-01

H.R. 3184 is a bill to establish within the Office of Minority Economics Impact of the Department of Energy (DOE) programs involving loans and grants to enhance the development and operation of minority business enterprises with respect to energy-related business, to amend the Nuclear Waste Policy Act of 1982 to permit the investment of certain funds in the Minority Bank Deposit Program of the Department of the Treasury, and for other purposes

HR-LC-MS based analysis of two antibacterial metabolites from a marine sponge symbiont Streptomyces pharmamarensis ICN40.

Science.gov (United States)

Joseph, Francis-Joseph Rosemary Sharmila; Iniyan, Appadurai Muthamil; Vincent, Samuel Gnana Prakash

2017-10-01

On the effort to screen antibiotics against Methicillin resistant Staphylococcus aureus (MRSA), an actinomycete strain which can produce bactericidal compound was isolated from a marine sponge of Kanyakumari Coast, India. Two anti-MRSA compounds (PVI401 and PVI402) were isolated from the fermentation plates of Streptomyces pharmamarensis ICN40. TLC bioautography analysis yielded two active spots with Rf value of 0.75 (PVI401) and 0.8 (PVI402) from the crude extract. Both the compounds were characterized by HR-LC-MS analysis. LC-MS based de-replication analysis found out the compound PVI401 with an exact mass of 376.09435 Da and PVI402 with an exact mass of 273.26795 Da were found to be unidentified. Antibacterial spectrum showed significant minimal inhibitory concentration as 0.5 μg/ml of PVI401 and 2 μg/ml of PVI402 against MRSA. The whole organism zebrafish safety evaluation exhibited the compound PVI402 is safe upto 1 mg/ml 40 μg/ml of PVI401 exhibited thrombosis in cardiac chamber and this compound exhibited 44 μg/ml of LC 50 against HepG2 hepatic carcinoma cell line. Both the compounds may be identified further for its structural novelty and clinical studies. Copyright © 2017 Elsevier Ltd. All rights reserved.

Performance of a Cryogenic Multipath Herriott Cell Vacuum-Coupled to a Bruker IFS-125HR System

Science.gov (United States)

Mantz, Arlan; Sung, Keeyoon; Crawford, Timothy J.; Brown, Linda; Smith, Mary Ann H.

2014-06-01

Accurate modeling of atmospheric trace gases requires detailed knowledge of spectroscopic line parameters at temperatures and pressures relevant to the atmospheric layers where the spectroscopic signatures form. Pressure-broadened line shapes, frequency shifts, and their temperature dependences, are critical spectroscopic parameters that limit the accuracy of state-of-the-art atmospheric remote sensing. In order to provide temperature dependent parameters from controlled laboratory experiments, a 20.946 ± 0.001 m long path Herriott cell and associated transfer optics were designed and fabricated at Connecticut College to operate in the near infrared using a Bruker 125 HR Fourier transform spectrometer. The cell body and gold coated mirrors are fabricated with Oxygen-Free High Conductivity (OFHC) copper. Transfer optics are through-put matched for entrance apertures smaller than 2 mm. A closed-cycle Helium refrigerator cools the cell and cryopumps the surrounding vacuum box. This new system and its transfer optics are fully evacuated to ˜10 mTorr (similar to the pressure inside the interferometer). Over a period of several months, this system has maintained extremely good stability in recording spectra at gas sample temperatures between 75 and 250 K. The absorption path length and cell temperatures are validated using CO spectra. The characterization of the Herriott cell is described along with its performance and future applications. We thank Drs. V. Malathy Devi and D. Chris Benner at The College of William and Mary for helpful discussion. Research described in this paper was performed at Connecticut College, the Jet Propulsion Laboratory, California Institute of Technology, and NASA Langley Research Center, under contracts and cooperative agreements with the National Aeronautics and Space Administration.

Destructive physical analysis of hollow cathodes from the Deep Space 1 Flight spare ion engine 30,000 hr life test

Science.gov (United States)

Sengupta, Anita

2005-01-01

Destructive physical analysis of the discharge and neutralizer hollow cathode assemblies from the Deep Space 1 Flight Spare 30,000 Hr life test was performed to characterize physical and chemical evidence of operationally induced effects after 30,372 hours of operation with beam extraction. Post-test inspection of the discharge-cathode assembly was subdivided into detailed analyses at the subcomponent level. Detailed materials analysis and optical inspection of the insert, orifice plate, cathode tube, heater, keeper assembly, insulator, and low-voltage propellant isolator were performed. Energy dispersive X-ray (EDX) and scanning electron microscopy (SEW analyses were used to determine the extent and composition of regions of net deposition and erosion of both the discharge and neutralizer inserts. A comparative approach with an un-operated 4:1:1 insert was used to determine the extent of impregnate material depletion as a function of depth from the ID surface and axial position from the orifice plate. Analysis results are compared and contrasted with those obtained from similar analyses on components from shorter term tests, and provide insight regarding the prospect for successful longer-term operation consistent with SOA ion engine program life objectives at NASA.

Mitigation action plan for liquid waste sites in the 100-BC-1, 100-DR-1, and 100-HR-1 units

International Nuclear Information System (INIS)

Weiss, S.G.

1996-05-01

A Record of Decision (ROD) was issued for remediation of waste sites in the 100-BC-1, 100-DR-1, and 100-HR-1 Operable Units in the 100 Area of the Hanford Site. This Mitigation Action Plan (MAP) explains how mitigation measures for these remedial activities will be planned and implemented. The new activities planned in the ROD are not anticipated to result in releases of hazardous substances and will minimize disturbance of currently undisturbed areas. However, certain actions required by the ROD may result in the redisturbance of areas of recovering vegetation. This MAP presents a strategy for limiting disturbances and identifies an opportunity for revegetating a previously disturbed site; the knowledge gained from this demonstration project can be applied to final revegetation of the rest of the remediated sites and sites disturbed during cleanup when remediation of an area is completed. This work will be conducted in coordination with the Natural Resource Trustees Council and Native American Tribes to help minimize impacts to natural resources and cultural resources from project activities and to restore the remediated sites to an appropriate level of habitat

PLEIADES HR IN FLIGHT GEOMETRICAL CALIBRATION : LOCATION AND MAPPING OF THE FOCAL PLANE

Directory of Open Access Journals (Sweden)

F. de Lussy

2012-07-01

Full Text Available The Pleiades system, ORFEO system optical component (Optical and Radar Federated Earth Observation consists of a constellation of two satellites for very High Resolution panchromatic and multispectral optical observation of the Earth. Its mission is to cover all European civilian needs (mapping, tracking floods and fires and defence in the category of metric resolution: 0.7m Nadir. The first Pleiades satellite was launched at the end of last year. One of the key objectives of the Pleiades HR (PHR project is to achieve a location accuracy that will allow the use of images in GIS (Geographical Information System without geometrical model improvement by refining on ground control points. The image location without refined model was specified with the precision of the most commonly used tool ie the civil GPS. So the location accuracy has been specified at less than 12m for 90% of the images on a nominal satellite configuration. Very special care has been taken all along the PHR project realization to achieve this very good location accuracy. The final touch is given during the in-orbit commissioning phase which lasts until June 2012. The geometric quality implies to tune the parameters involved in the geolocation model (geometric calibration: besides attitude and orbit restitution tuning (not considered here, it consists in estimating the biases between the instrument orientation and the AOCS reference frame, and also the sight line of each detector in the focal plane. This is called static geometrical model. The analysis of dynamic perturbations outside of the model are the second most important image quality objective of in-flight commissioning, not described in this paper. Finally “image quality assessment” consists in evaluating the image quality obtained in the final products. For geolocation model, it is quantified by the absolute geolocation and the pointing accuracies, and it is a main contributor in length alteration and planimetric and

Alterations of bone density, microstructure, and strength of the distal radius in male patients with rheumatoid arthritis: a case-control study with HR-pQCT.

Science.gov (United States)

Zhu, Tracy Y; Griffith, James F; Qin, Ling; Hung, Vivian W; Fong, Tsz-Ning; Au, Sze-Ki; Li, Martin; Lam, Yvonne Yi-On; Wong, Chun-Kwok; Kwok, Anthony W; Leung, Ping-Chung; Li, Edmund K; Tam, Lai-Shan

2014-09-01

In this cross-sectional study, we investigated volumetric bone mineral density (vBMD), bone microstructure, and biomechanical competence of the distal radius in male patients with rheumatoid arthritis (RA). The study cohort comprised 50 male RA patients of average age of 61.1 years and 50 age-matched healthy males. Areal BMD (aBMD) of the hip, lumbar spine, and distal radius was measured by dual-energy X-ray absorptiometry. High-resolution peripheral quantitative computed tomography (HR-pQCT) of the distal radius provided measures of cortical and trabecular vBMD, microstructure, and biomechanical indices. aBMD of the hip but not the lumbar spine or ultradistal radius was significantly lower in RA patients than controls after adjustment for body weight. Total, cortical, and trabecular vBMD at the distal radius were, on average, -3.9% to -23.2% significantly lower in RA patients, and these differences were not affected by adjustment for body weight, testosterone level, or aBMD at the ultradistal radius. Trabecular microstructure indices were, on average, -8.1% (trabecular number) to 28.7% (trabecular network inhomogeneity) significantly inferior, whereas cortical pore volume and cortical porosity index were, on average, 80.3% and 63.9%, respectively, significantly higher in RA patients. RA patients also had significantly lower whole-bone stiffness, modulus, and failure load, with lower and more unevenly distributed cortical and trabecular stress. Density and microstructure indices significantly correlated with disease activity, severity, and levels of pro-inflammatory cytokines (interleukin [IL] 12p70, tumor necrosis factor, IL-6 and IL-1β). Ten RA patients had focal periosteal bone apposition most prominent at the ulnovolar aspect of the distal radius. These patients had shorter disease duration and significantly higher cortical porosity. In conclusion, HR-pQCT reveals significant alterations of bone density, microstructure, and strength of the distal radius in

Simultaneous measurement of {sup 239}Pu, {sup 240}Pu, {sup 241}Pu, and {sup 242}Pu by high resolution inductively coupled plasma mass spectrometer (HR ICP-MS) in marine sediments; Mesure des isotopes du plutonium des sediments marins par spectrometrie de masse a plasma couple inductivement haute resolution (HR ICP-MS)

Energy Technology Data Exchange (ETDEWEB)

Bruneau, F

1999-07-01

Transuranics elements are of particular interest in radioecological studies because of their radiotoxicity and their potential use to decipher source fingerprints and transport processes. The simultaneous measurement of {sup 239}Pu, {sup 240}Pu, {sup 241}Pu, and {sup 242}Pu in environmental samples requires a specific chemical procedure. This work deals with an analytical procedure which yields a very high grade of purification of Pu suitable for ultra low level detection by HR ICP-MS, from marine sediments. After the elimination of major elements (Fe, Al, Mg...) by a first chromatographic separation, a new device of purification by solvent extraction and concentration by a second chromatographic separation is used to obtain a concentrated and high purified solution of plutonium. The chemical procedure have been validated on IAEA certified sediment samples and on sediment samples collected in the roads of Cherbourg which had been previously analysed by other techniques (a spectrometry and thermo-ionisation mass spectrometer). (author)

Telecommuting. Hearing on H.R. 5082, A Bill To Promote the Use of Telecommuting, before the Subcommittee on Telecommunications and Finance of the Committee on Energy and Commerce. House of Representatives, One Hundred Second Congress, Second Session.

Science.gov (United States)

Congress of the U.S., Washington, DC. House Committee on Energy and Commerce.

This hearing on H.R. 5082, "The Telecommuting Act of 1992," focuses on how the developing telecommunications infrastructure can provide major benefits to the environment, employers, and the daily life of working people, who now have the ability to telecommute to their office from some alternative work site located nearer to their home.…

The Improvement of HR-management as a Factor of Increasing of Companies’ Competitiveness in the Labour Market

Directory of Open Access Journals (Sweden)

Buyar Kateryna

2015-09-01

Full Text Available In my article were researched market economy mechanisms for increasing the competitiveness of companies in the labour market. The paper target was to prove the need to use economic and administrative mechanisms to improve a level of competitiveness of the company in the labour market. Such researches become more important today, because after my empirical analyse of literature I can only conclude that not a lot of researchers studied in this field of science and the most theories suggest that only employees must be competitive on the labour market. But as a result of my research I can deny this one-sided view and can confirm that nowadays not just employees, but also employers compete with each other in the labour market. So, successful organizations must pay big attention to the processes of HR-management, which must be improved. But not enough attention is paid to the system of management and its impact on workers. It is important to form close links between existing system management with inherent for company effective economic management mechanisms in the companies with the level of competitiveness of the company in the labour market. So the results of my research showed that companies must develop economic and administrative mechanisms to improve their competitiveness in the labour market. These mechanisms are a set of applied styles and methods of management that have a direct impact on the loyalty of workers and consequently, enhance its competitiveness both inside the company and in external labour markets. So I can conclude that the paper target was achieved.

H.R. 2372: A Bill to provide jurisdiction and procedures for claims for compassionate payments for injuries due to exposure to radiation from nuclear testing. Introduced in the House of Representatives, One Hundredth First Congress, First Session, May 16, 1989

International Nuclear Information System (INIS)

Anon.

1989-01-01

H.R. 2372 is a bill to provide jurisdiction and procedures for claims for compassionate payments for injuries due to exposure to radiation from nuclear testing. The Act proposes the use of a Trust Fund Board of Directors to disburse funds under prescribed conditions

Identification of Phenolic Compounds in Red and Green Pistachio (Pistacia vera L.) Hulls (Exo- and Mesocarp) by HPLC-DAD-ESI-(HR)-MS(n).

Science.gov (United States)

Erşan, Sevcan; Güçlü Üstündağ, Özlem; Carle, Reinhold; Schweiggert, Ralf M

2016-07-06

Phenolic constituents of the nonlignified red and green pistachio hulls (exo- and mesocarp) were assessed by HPLC-DAD-ESI-MS(n) as well as by HR-MS. A total of 66 compounds was identified in the respective aqueous methanolic extracts. Among them, gallic acid, monogalloyl glucoside, monogalloyl quinic acid, penta-O-galloyl-β-d-glucose, hexagalloyl hexose, quercetin 3-O-galactoside, quercetin 3-O-glucoside, quercetin 3-O-glucuronide, and (17:1)-, (13:0)-, and (13:1)-anacardic acids were detected at highest signal intensity. The main difference between red and green hulls was the presence of anthocyanins in the former ones. Differently galloylated hydrolyzable tannins, anthocyanins, and minor anacardic acids were identified for the first time. Pistachio hulls were thus shown to be a source of structurally diverse and potentially bioactive phenolic compounds. They therefore represent a valuable byproduct of pistachio processing having potential for further utilization as raw material for the recovery of pharmaceutical, nutraceutical, and chemical products.

Comparative study of a novel application of automated HR HPV assay and stability in a previously untested Preservative media.

Science.gov (United States)

Morel, Mike E; McBride, Simon E; Gomez, Maria P

2017-12-01

The suitability and stability of cervical cells in Novaprep media (NHQ) for certain HPV assays is unknown. We evaluated the accuracy of an automated HPV assay (Abbott RealTime HR HPV) for cervical cells prepared in NHQ and NHQ with a pre-treatment to mimic a worst case clinical use, compared to the assay manufacturers media; repeatability and reproducibility of HPV results and the stability of detectable HPV in NHQ over time compared to CE marked liquid based cytology preservatives. Cell lines were used to simulate patient samples. Cells stored in NHQ produced accurate, repeatable and reproducible results. Stability in NHQ was comparable to the best performing LBC, with at least 7 months' stability at 18-25°C, 2-8°C, -20°C and -80°C; and at least 3 months' stability at 40°C. Similar results were obtained for pre-treated NHQ except only 3.5 months' stability at 18-25°C. Cell line samples in all media and concentrations tested were detected appropriately by the assay. Based on this first stage validation analytical study, cervical cells stored in NHQ are suitable for the Realtime HPV assay. There should be no reservations for inclusion of NHQ in any further validation and clinical performance evaluation of this assay. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

A new look at the origin of the 6.67 hr period X-ray pulsar 1E 161348-5055

Science.gov (United States)

Ikhsanov, N. R.; Kim, V. Y.; Beskrovnaya, N. G.; Pustil'nik, L. A.

2013-07-01

The point X-ray source 1E 161348-5055 is observed to display pulsations with the period 6.67 hr and |dot{P}| ≤1.6 ×10^{-9} s s^{-1}. It is associated with the supernova remnant RCW 103 and is widely believed to be a ˜2000 yr old neutron star. Observations give no evidence for the star to be a member of a binary system. Nevertheless, it resembles an accretion-powered pulsar with the magnetospheric radius ˜3000 km and the mass-accretion rate ˜ 10^{14} g s^{-1}. This situation could be described in terms of accretion from a (residual) fossil disk established from the material falling back towards the star after its birth. However, current fall-back accretion scenarios encounter major difficulties explaining an extremely long spin period of the young neutron star. We show that the problems can be avoided if the accreting material is magnetized. The star in this case is surrounded by a fossil magnetic slab in which the material is confined by the magnetic field of the accretion flow itself. We find that the surface magnetic field of the neutron star within this scenario is ˜1012 G and that a presence of ≳10^{-7} M_{⊙} magnetic slab would be sufficient to explain the origin and current state of the pulsar.

Analyses of the eustachian tube and its surrounding tissues with cross sectional images by high-resolution computed tomography (HR-CT)

International Nuclear Information System (INIS)

Yoshida, Haruo; Kobayashi, Toshimitsu; Takasaki, Kenji; Kanda, Yukihiko; Nakao, Yoshiaki; Morikawa, Minoru; Ishimaru, Hideki; Hayashi, Kuniaki

2000-01-01

We attempted to image the eustachian tube (ET) and its surrounding tissues by high-resolution computed tomography (HR-CT). Twenty-two normal subjects (44 ears) without middle ear problems were studied, and a patient with severe patulous ET was also studied as an abnormal case. In our device of multiplanar reconstruction technique, we were able to obtain the clear reconstructed images of the ET lumen as well as of its surrounding tissues (bone, ET cartilage, tensor veli palatini muscle, levator veli palatini muscle, Ostmann's fat tissue, tensor tympani muscle, internal carotid artery) at any desired portion, either parallel or perpendicular to the long axis of the ET. However, the exact borders between the ET cartilage and the muscles, Ostmann's fat tissue and the tubal gland were not clearly identified. In the severe case of patulous ET, the ET lumen was widely opened at each cross-sectional image from the pharyngeal orifice to the tympanic orifice, in contrast with its being closed at the cartilaginous portion in the normal cases. In addition, the fat tissue and glands around the ET lumen were not clearly identified in this case. We suggest that this method will lead to better understanding of the ET-related diseases such as patulous ET. (author)

Analyses of the eustachian tube and its surrounding tissues with cross sectional images by high-resolution computed tomography (HR-CT)

Energy Technology Data Exchange (ETDEWEB)

Yoshida, Haruo; Kobayashi, Toshimitsu; Takasaki, Kenji; Kanda, Yukihiko; Nakao, Yoshiaki; Morikawa, Minoru; Ishimaru, Hideki; Hayashi, Kuniaki [Nagasaki Univ. (Japan). School of Medicine

2000-07-01

We attempted to image the eustachian tube (ET) and its surrounding tissues by high-resolution computed tomography (HR-CT). Twenty-two normal subjects (44 ears) without middle ear problems were studied, and a patient with severe patulous ET was also studied as an abnormal case. In our device of multiplanar reconstruction technique, we were able to obtain the clear reconstructed images of the ET lumen as well as of its surrounding tissues (bone, ET cartilage, tensor veli palatini muscle, levator veli palatini muscle, Ostmann's fat tissue, tensor tympani muscle, internal carotid artery) at any desired portion, either parallel or perpendicular to the long axis of the ET. However, the exact borders between the ET cartilage and the muscles, Ostmann's fat tissue and the tubal gland were not clearly identified. In the severe case of patulous ET, the ET lumen was widely opened at each cross-sectional image from the pharyngeal orifice to the tympanic orifice, in contrast with its being closed at the cartilaginous portion in the normal cases. In addition, the fat tissue and glands around the ET lumen were not clearly identified in this case. We suggest that this method will lead to better understanding of the ET-related diseases such as patulous ET. (author)

Health-related quality of life and disease symptoms in postmenopausal women with HR(+), HER2(-) advanced breast cancer treated with everolimus plus exemestane versus exemestane monotherapy.

Science.gov (United States)

Campone, Mario; Beck, J Thaddeus; Gnant, Michael; Neven, Patrick; Pritchard, Kathleen I; Bachelot, Thomas; Provencher, Louise; Rugo, Hope S; Piccart, Martine; Hortobagyi, Gabriel N; Nunzi, Martina; Heng, Daniel Y C; Baselga, José; Komorowski, Anna; Noguchi, Shinzaburo; Horiguchi, Jun; Bennett, Lee; Ziemiecki, Ryan; Zhang, Jie; Cahana, Ayelet; Taran, Tetiana; Sahmoud, Tarek; Burris, Howard A

2013-11-01

Everolimus (EVE)+exemestane (EXE; n = 485) more than doubled median progression-free survival versus placebo (PBO) + EXE (n = 239), with a manageable safety profile and no deterioration in health-related quality-of-life (HRQOL) in patients with hormone-receptor-positive (HR(+)) advanced breast cancer (ABC) who recurred or progressed on/after nonsteroidal aromatase inhibitor (NSAI) therapy. To further evaluate EVE + EXE impact on disease burden, we conducted additional post-hoc analyses of patient-reported HRQOL. HRQOL was assessed using EORTC QLQ-C30 and QLQ-BR23 questionnaires at baseline and every 6 weeks thereafter until treatment discontinuation because of disease progression, toxicity, or consent withdrawal. Endpoints included the QLQ-C30 Global Health Status (QL2) scale, the QLQ-BR23 breast symptom (BRBS), and arm symptom (BRAS) scales. Between-group differences in change from baseline were assessed using linear mixed models with selected covariates. Sensitivity analysis using pattern-mixture models determined the effect of study discontinuation on/before week 24. Treatment arms were compared using differences of least squares mean (LSM) changes from baseline and 95% confidence intervals (CIs) at each timepoint and overall. Clinicaltrials.gov: NCT00863655. Progression-free survival, survival, response rate, safety, and HRQOL. Linear mixed models (primary model) demonstrated no statistically significant overall difference between EVE + EXE and PBO + EXE for QL2 (LSM difference = -1.91; 95% CI = -4.61, 0.78), BRBS (LSM difference = -0.18; 95% CI = -1.98, 1.62), or BRAS (LSM difference = -0.42; 95% CI = -2.94, 2.10). Based on pattern-mixture models, patients who dropped out early had worse QL2 decline on both treatments. In the expanded pattern-mixture model, EVE + EXE-treated patients who did not drop out early had stable BRBS and BRAS relative to PBO + EXE. HRQOL data were not collected after disease progression. These analyses confirm

Precise isotope ratio and multielement determination in prehistoric and historic human skeletal remains by HR-ICPMS - a novel application to shed light onto anthropological and archaeological questions

International Nuclear Information System (INIS)

Watkins, M.

2000-12-01

The primary aim of the presented work was the analytical setup for fast (including high sample throughput for statistical evaluation), precise and accurate measurement of strontium isotope ratios using HR-ICPMS (high-resolution inductively coupled plasma mass spectrometry) and their application to ancient human skeletal remains from different localities for the reconstruction of migration processes. Soils and plants are in isotopic equilibrium with local source rock and show therefore the same isotopic ratios for strontium (87Sr/86Sr). Dietary strontium incorporation varies for different body materials (teeth, muscle, bone, etc.) and repository periods depend on the different strontium turnover rates. Accordingly, strontium isotope analysis can provide important data for studying human or animal migration and mobility. An important issue will be addressed: the problem of strontium isotope ratio measurement reliability and the problem of post-mortem alterations. Thus a basic part of this interdisciplinary project is dealing with the systematic evaluation of diagenetic changes of the microstructure in human bone samples - including sample uptake and preparation. Different invasive histological techniques will be applied for further clarification. Newly developed chemical methods give us the opportunity to obtain details on ancient population mobility also in skeletal series of extreme fragmentary character, which usually restricts the macro-morphological approach. Since it is evident that strontium in teeth is only incorporated during childhood whereas strontium uptake in bones is constant, an intra-individual comparison of bone and teeth samples will answer the question whether teeth are indeed 'archives of the childhood'. The introduction of an analytical system allowing online matrix separation by High Performance Ion Chromatography (HPIC) and subsequent measurement of strontium isotope ratios by means of HR-ICPMS is presented, optimized and established as method

Precise Isotope ratio and multielement determination in prehistoric and historic human skeletal remains by HR-ICPMS - a novel application to shed light onto anthropological and archaeological questions

International Nuclear Information System (INIS)

Watkins, M.

2000-12-01

The primary aim of the presented work was the analytical setup for fast (including high sample throughput for statistical evaluation), precise and accurate measurement of strontium isotope ratios using HR-ICPMS (high-resolution inductively coupled plasma mass spectrometry) and their application to ancient human skeletal remains from different localities for the reconstruction of migration processes. Soils and plants are in isotopic equilibrium with local source rock and show therefore the same isotopic ratios for strontium (87Sr/86Sr). Dietary strontium incorporation varies for different body materials (teeth, muscle, bone, etc.) and repository periods depend on the different strontium turnover rates. Accordingly, strontium isotope analysis can provide important data for studying human or animal migration and mobility. An important issue will be addressed: the problem of strontium isotope ratio measurement reliability and the problem of post-mortem alterations. Thus a basic part of this interdisciplinary project is dealing with the systematic evaluation of diagenetic changes of the microstructure in human bone samples - including sample uptake and preparation. Different invasive histological techniques will be applied for further clarification. Newly developed chemical methods give us the opportunity to obtain details on ancient population mobility also in skeletal series of extreme fragmentary character, which usually restricts the macro-morphological approach. Since it is evident that strontium in teeth is only incorporated during childhood whereas strontium uptake in bones is constant, an intra-individual comparison of bone and teeth samples will answer the question whether teeth are indeed 'archives of the childhood'. The introduction of an analytical system allowing online matrix separation by High Performance Ion Chromatography (HPIC) and subsequent measurement of strontium isotope ratios by means of HR-ICPMS is presented, optimized and established as method

H.R. 2662: This Act may be cited as the Department of Energy Nuclear Contractors Accountability and Award System Act of 1989. Introduced in the House of Representatives, One Hundredth First Congress, First Session, June 15, 1989

International Nuclear Information System (INIS)

Anon.

1989-01-01

H.R. 2662 is a bill to prohibit the Department of Energy from paying fines or penalties assessed against national security program contractors for violation of laws or regulations and to direct the Secretary of Energy to revise the system of award fees to such contractors to encourage discovery and remedy of conditions and practices that could lead to such violations

Electric Field-Dependent Photoluminescence in Multilayer Transition Metal Dichalcogenides

Science.gov (United States)

Stanev, T. K.; Henning, A.; Sangwan, V. K.; Speiser, N.; Stern, N. P.; Lauhon, L. J.; Hersam, M. C.; Wang, K.; Valencia, D.; Charles, J.; Kubis, T. C.

Owing to interlayer coupling, transition metal dichalcogenides (TMDCs) such as MoS2 exhibit strong layer dependence of optical and electronic phenomena such as the band gap and trion and neutral exciton population dynamics. Here, we systematically measure the effect of layer number on the optical response of multilayer MoS2 in an external electric field, observing field and layer number dependent emission energy and photoluminescence intensity. These effects are studied in few (2-6) and bulk (11 +) layered structures at low temperatures. In MoS2\\ the observed layer dependence arises from several mechanisms, including interlayer charge transfer, band structure, Stark Effect, Fermi level changes, screening, and surface effects, so it can be challenging to isolate how these mechanisms impact the observables. Because it behaves like a stack of weakly interacting monolayers rather than multilayer or bulk, ReS2 provides a comparison to traditional TMDCs to help isolate the underlying physical mechanisms dictating the response of multilayers. This work is supported by the National Science Foundation MRSEC program (DMR-1121262), and the 2-DARE Grant (EFRI-1433510). N.P.S. is an Alfred P. Sloan Research Fellow.

H.R. 2278: A Bill to provide for the establishment of a uranium enrichment corporation, and for other purposes. Introduced in the House of Representatives, One Hundredth First Congress, First Session, May 9, 1989

International Nuclear Information System (INIS)

Anon.

1989-01-01

H.R. 2278 is a bill to provide for the establishment of a uranium enrichment corporation, and for other purposes. The purpose of the Act is to create a uranium enrichment corporation which will be an efficient provider of uranium enrichment services able, insofar as is consistent with maximizing the value of the Corporation, to meet the needs of the United States for uranium enrichment services, and which will be suitable for eventual transfer to private ownership

H.R. 5433: This Act may be cited as the Nuclear Fuel Utilization and Domestic Production Act of 1988. Introduced in the House of Representatives, One Hundredth Congress, Second Session, September 30, 1988

International Nuclear Information System (INIS)

Anon.

1988-01-01

H.R. 5433 is a bill to assist in creating a viable domestic uranium enrichment industry, to insure the maximum economic utilization of the existing diffusion plant assets, to establish mechanisms which would permit the creation of a privately owned corporation to utilize the Federal Government's investment in centrifuge technology and in the centrifuge assets, to establish alternate sources of enrichment supply, so as to create American jobs, to return moneys to the Government and to increase American industrial competitiveness in world wide nuclear fuel sales

Comparative evaluation of two commercial PET scanners, ECAT EXACT HR+ and Biograph 2, using GATE

International Nuclear Information System (INIS)

Karakatsanis, N.; Sakellios, N.; Tsantilas, N.X.; Dikaios, N.; Tsoumpas, C.; Lazaro, D.; Loudos, G.; Schmidtlein, C.R.; Louizi, K.; Valais, J.; Nikolopoulos, D.; Malamitsi, J.; Kandarakis, J.; Nikita, K.

2006-01-01

Geant4 application for tomographic emission (GATE) is a generic Monte Carlo simulation platform based on a general-purpose code GEANT4 and designed to simulate positron emission tomography (PET) and single photon emission tomography systems. Monte Carlo simulations are used in nuclear medicine to model imaging systems and develop and assess tomographic reconstruction algorithms and correction methods for improved image quantification. The purpose of this study is to validate two GATE models of the commercial available PET scanner HR+ and the PET/CT Biograph 2. The geometry of the system components has been described in GATE, including detector ring, crystal blocks, PMTs etc. The energy and spatial resolution of the scanners as given by the manufacturers have been taken into account. The GATE simulated results are compared directly to experimental data obtained using a number of NEMA NU-2-2001 performance protocols, including spatial resolution, sensitivity and scatter fraction. All the respective phantoms are precisely modeled. Furthermore, an approximate dead-time model both at the level of single and coincidence events was developed so that the simulated count rate curve can satisfactorily match the experimental count rate performance curve for each scanner In addition a software tool was developed to build the sinograms from the simulated data and import them into the software for tomographic image reconstruction where the reconstruction algorithm of FBP3DRP was applied. An agreement of less than 0.8 mm was obtained between the spatial resolution of the simulated system and the experimental results. Also the simulated scatter fraction for the NEMA NU 2-2001 scatter phantom matched the experimental results to within 3% of measured values. Finally the ratio of the simulated sensitivities with sources radially offset 0 and 10 cm from the central axis of each of the two scanners reaches an agreement of less than 1% between the simulated and experimental values. This

Mapping Changes and Damages in Areas of Conflict: From Archive C-Band SAR Data to New HR X-Band Imagery, Towards the Sentinels

Science.gov (United States)

Tapete, Deodato; Cigna, Francesca; Donoghue, Daniel N. M.; Philip, Graham

2015-05-01

On the turn of radar space science with the recent launch of Sentinel-1A, we investigate how to better exploit the opportunities offered by large C-band SAR archives and increasing datasets of HR to VHR X-band data, to map changes and damages in urban and rural areas affected by conflicts. We implement a dual approach coupling multi-interferogram processing and amplitude change detection, to assess the impact of the recent civil war on the city of Homs, Western Syria, and the surrounding semi-arid landscape. More than 280,000 coherent pixels are retrieved from Small BAseline Subset (SBAS) processing of the 8year-long ENVISAT ASAR IS2 archive, to quantify land subsidence due to pre-war water abstraction in rural areas. Damages in Homs are detected by analysing the changes of SAR backscattering (σ0), comparing 3m-resolution StripMap TerraSAR-X pairs from 2009 to 2014. Pre-war alteration is differentiated from war-related damages via operator-driven interpretation of the σ0 patterns.

Oral nanotherapeutics: Redox nanoparticles attenuate ultraviolet B radiation-induced skin inflammatory disorders in Kud:Hr- hairless mice.

Science.gov (United States)

Feliciano, Chitho P; Nagasaki, Yukio

2017-10-01

The active participation of an anti-inflammatory drug in the biological pathways of inflammation is crucial for the achievement of beneficial and therapeutic effects. This study demonstrated the development of redox nanoparticles that can circulate in the blood at significantly high levels, thus increasing their efficacy as an oral treatment against the deleterious effects of reactive oxygen species (ROS) in an in vivo inflammatory skin model. To confirm the blood bioavailability of the nanoparticles, mice were injected with the nanoparticles solution (RNP N ) via oral gavage. Using electron spin resonance and radioactive labeling techniques, the blood circulation of the redox polymer that forms the nanoparticles was confirmed 24 h after oral administration. This contrasted with its low molecular weight counterpart (NH 2 -TEMPO), which peaked 15 min post injection and was found to be cleared rapidly within minutes after the peak. We then tested its efficacy in the inflammatory skin model. Kud:Hr-hairless mice were irradiated with UVB (302 nm) to induce skin damage and inflammation. Throughout the entire period of UVB irradiation, RNP N was administered to mice by free drinking. NH 2 -TEMPO was used as the control. The results showed that oral supplementation of RNP N significantly improved the therapeutic effects of the core nitroxide radical compared with its low molecular weight counterpart. Furthermore, RNP N significantly reduced UVB-induced skin aging, epidermal thickening, edema, erythema, skin lesions, and various pathological skin inflammatory disorders in vivo. From the obtained data, we concluded that the use of long-circulating redox nanoparticles (RNP N ) provided an effective treatment against the damaging effects of excessive ROS in the body. Copyright © 2017 Elsevier Ltd. All rights reserved.

H.R. 3521: Nuclear Facilities Occupational Safety Improvement Act of 1989. Introduced in the House of Representatives, One Hundredth First Congress, First Session, October 25, 1989

International Nuclear Information System (INIS)

Anon.

1989-01-01

Bill H.R.3521 was introduced in the House of Representatives of the United States on October 25, 1989. The purpose of this Act and the amendments made by this Act are to improve and enforce standards for employee health and safety at Department of Energy nuclear facilities. Congress finds that worker health and safety at Department of Energy nuclear facilities could be made substantially safer by applying standards developed by experts in the field of occupational health and safety. A section-by-section analysis makes up most of the report with emphasis on the following: application of OSHA to DOE nuclear facilities; cooperation with inspections and investigations; transfer and allocation of appropriations and personnel; worker training requirements; performance of NIOSH functions at DOE nuclear facilities; medical examinations of employees; and labor-management health and safety committees at DOE nuclear facilities

Highlights of analytical chemistry in Switzerland. Spatially resolved plant physiological analysis using LA-HR-ICP-MS

Energy Technology Data Exchange (ETDEWEB)

Ulrich, A. [Swiss Federal Laboratories for Material Testing and Research (EMPA), Duebendorf (Switzerland); Barrelet, T. [Federal Office of Public Health (FOPH), Berne (Switzerland); Kraehenbuehl, U. [University of Berne, Department for Chemistry and Biochemistry, Berne (Switzerland)

2007-06-15

Investigations of elemental distribution in trees are interesting in plant physiological and environmental research. Seasonal element variations within single tree rings would provide important information on metabolism studies but they have not been accessible so far. Thus, a direct micro-analytical method involving laser ablation (LA) coupled to high-resolution double-focusing magnetic sector field inductively coupled plasma mass spectrometry (HR-ICP-MS) was developed. Particularly challenging aspects in method development were the high background levels of certain elements and the lack of appropriate calibration standards. Seasonal element profiles of macronutrients in Norway spruce trees from different sampling sites, altitudes and environmental conditions could be established for the first time. The method allows the measurement of low concentrations even in narrow year rings. Depending on the tree ring width, the number of laser spots per ring varied between four and eight. For discussion purposes, each ring was divided in four distinct zones commonly used in dendrology: early earlywood (EEW), late earlywood (LEW), early latewood (ELW) and late latewood (LLW). The sulphur profile displayed seasonal variations with decreasing contents in LEW and ELW, which leads to the assumption that stem sulphur is used for seasonal growth. When accrescence stops in autumn, sulphur reserves are stored in preparation for next year's growth, since methionine in tree sap was found to increase in March until July and decrease in August. A seasonal pattern was also found for phosphorus. This contradicts the hypothesis of a constant supply by mycorrhizal fungi and implies that reserves are stored towards the end of growing season for use the following spring. The linear relationship between phosphorus and sulphur underlines a strong biochemical coupling of both elements. Other macronutrients like potassium show different profiles. Potassium is of particular importance in

Highlights of analytical chemistry in Switzerland. Spatially resolved plant physiological analysis using LA-HR-ICP-MS

International Nuclear Information System (INIS)

Ulrich, A.; Barrelet, T.; Kraehenbuehl, U.

2007-01-01

Investigations of elemental distribution in trees are interesting in plant physiological and environmental research. Seasonal element variations within single tree rings would provide important information on metabolism studies but they have not been accessible so far. Thus, a direct micro-analytical method involving laser ablation (LA) coupled to high-resolution double-focusing magnetic sector field inductively coupled plasma mass spectrometry (HR-ICP-MS) was developed. Particularly challenging aspects in method development were the high background levels of certain elements and the lack of appropriate calibration standards. Seasonal element profiles of macronutrients in Norway spruce trees from different sampling sites, altitudes and environmental conditions could be established for the first time. The method allows the measurement of low concentrations even in narrow year rings. Depending on the tree ring width, the number of laser spots per ring varied between four and eight. For discussion purposes, each ring was divided in four distinct zones commonly used in dendrology: early earlywood (EEW), late earlywood (LEW), early latewood (ELW) and late latewood (LLW). The sulphur profile displayed seasonal variations with decreasing contents in LEW and ELW, which leads to the assumption that stem sulphur is used for seasonal growth. When accrescence stops in autumn, sulphur reserves are stored in preparation for next year's growth, since methionine in tree sap was found to increase in March until July and decrease in August. A seasonal pattern was also found for phosphorus. This contradicts the hypothesis of a constant supply by mycorrhizal fungi and implies that reserves are stored towards the end of growing season for use the following spring. The linear relationship between phosphorus and sulphur underlines a strong biochemical coupling of both elements. Other macronutrients like potassium show different profiles. Potassium is of particular importance in needles

Study on Practical Significance of HR Soft Management in Enterprises%企业人力资源柔性管理模式的实践意义探究

Institute of Scientific and Technical Information of China (English)

张力宏

2011-01-01

Soft management, centering on ＂human talents＂, regards HR as enterprises＂ sources and focuses on the management of ＂human minds＂. Applying soft management in HRM can help realize the organizational goals, satisfy employees＇ demand and encourage employee＇s overall development.%柔性管理模式以“人”为中心，将人力视为企业的资源，强调对“心”的管理。在人力资源管理中运用柔性管理模式，有助于实现组织目标、有助于满足员工需求、有助于激励员工全面发展。