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Sample records for putative primordial genetic

  1. Exceptional error minimization in putative primordial genetic codes

    Directory of Open Access Journals (Sweden)

    Koonin Eugene V

    2009-11-01

    Full Text Available Abstract Background The standard genetic code is redundant and has a highly non-random structure. Codons for the same amino acids typically differ only by the nucleotide in the third position, whereas similar amino acids are encoded, mostly, by codon series that differ by a single base substitution in the third or the first position. As a result, the code is highly albeit not optimally robust to errors of translation, a property that has been interpreted either as a product of selection directed at the minimization of errors or as a non-adaptive by-product of evolution of the code driven by other forces. Results We investigated the error-minimization properties of putative primordial codes that consisted of 16 supercodons, with the third base being completely redundant, using a previously derived cost function and the error minimization percentage as the measure of a code's robustness to mistranslation. It is shown that, when the 16-supercodon table is populated with 10 putative primordial amino acids, inferred from the results of abiotic synthesis experiments and other evidence independent of the code's evolution, and with minimal assumptions used to assign the remaining supercodons, the resulting 2-letter codes are nearly optimal in terms of the error minimization level. Conclusion The results of the computational experiments with putative primordial genetic codes that contained only two meaningful letters in all codons and encoded 10 to 16 amino acids indicate that such codes are likely to have been nearly optimal with respect to the minimization of translation errors. This near-optimality could be the outcome of extensive early selection during the co-evolution of the code with the primordial, error-prone translation system, or a result of a unique, accidental event. Under this hypothesis, the subsequent expansion of the code resulted in a decrease of the error minimization level that became sustainable owing to the evolution of a high

  2. Primordial dwarfism: overview of clinical and genetic aspects.

    Science.gov (United States)

    Khetarpal, Preeti; Das, Satrupa; Panigrahi, Inusha; Munshi, Anjana

    2016-02-01

    Primordial dwarfism is a group of genetic disorders which include Seckel Syndrome, Silver-Russell Syndrome, Microcephalic Osteodysplastic Primordial Dwarfism types I/III, II and Meier-Gorlin Syndrome. This genetic disorder group is characterized by intra-uterine growth retardation and post-natal growth abnormalities which occur as a result of disorganized molecular and genomic changes in embryonic stage and, thus, it represents a unique area to study growth and developmental abnormalities. Lot of research has been carried out on different aspects; however, a consolidated review that discusses an overall spectrum of this disorder is not accessible. Recent research in this area points toward important molecular and cellular mechanisms in human body that regulate the complexity of growth process. Studies have emerged that have clearly associated with a number of abnormal chromosomal, genetic and epigenetic alterations that can predispose an embryo to develop PD-associated developmental defects. Finding and associating such fundamental changes to its subtypes will help in re-examination of alleged functions at both cellular and developmental levels and thus reveal the intrinsic mechanism that leads to a balanced growth. Although such findings have unraveled a subtle understanding of growth process, we further require active research in terms of identification of reliable biomarkers for different subtypes as an immediate requirement for clinical utilization. It is hoped that further study will advance the understanding of basic mechanisms regulating growth relevant to human health. Therefore, this review has been written with an aim to present an overview of chromosomal, molecular and epigenetic modifications reported to be associated with different subtypes of this heterogenous disorder. Further, latest findings with respect to clinical and molecular genetics research have been summarized to aid the medical fraternity in their clinical utility, for diagnosing disorders

  3. Genetics Home Reference: microcephalic osteodysplastic primordial dwarfism type II

    Science.gov (United States)

    ... Twitter Home Health Conditions MOPDII microcephalic osteodysplastic primordial dwarfism type II Printable PDF Open All Close All ... the expand/collapse boxes. Description Microcephalic osteodysplastic primordial dwarfism type II ( MOPDII ) is a condition characterized by ...

  4. The primordial sequence, ribosomes, and the genetic code.

    Science.gov (United States)

    Fox, S. W.; Yuki, A.; Waehneldt, T. V.; Lacey, J. C., Jr.

    1971-01-01

    Experimental investigation of the key question of the origin of life concerning the chronological order in the primordial sequence of nucleic acid, protein, and cell. It is pointed out that, when viewed against the background of experiments on the selective reaction of basic homopolyamine acids with mononucleotides (Lacey and Pruitt, 1969; Woese, 1968), the experiments made help to establish a basis for understanding how information originally flowed from proteins to nucleic acids.

  5. Efficient genetic modification and germ-line transmission of primordial germ cells using piggyBac and Tol2 transposons.

    Science.gov (United States)

    Macdonald, Joni; Taylor, Lorna; Sherman, Adrian; Kawakami, Koichi; Takahashi, Yoshiko; Sang, Helen M; McGrew, Michael J

    2012-06-05

    The derivation of germ-line competent avian primordial germ cells establishes a cell-based model system for the investigation of germ cell differentiation and the production of genetically modified animals. Current methods to modify primordial germ cells using DNA or retroviral vectors are inefficient and prone to epigenetic silencing. Here, we validate the use of transposable elements for the genetic manipulation of primordial germ cells. We demonstrate that chicken primordial germ cells can be modified in vitro using transposable elements. Both piggyBac and Tol2 transposons efficiently transpose primordial germ cells. Tol2 transposon integration sites were spread throughout both the macro- and microchromosomes of the chicken genome and were more prevalent in gene transcriptional units and intronic regions, consistent with transposon integrations observed in other species. We determined that the presence of insulator elements was not required for reporter gene expression from the integrated transposon. We further demonstrate that a gene-trap cassette carried in the Tol2 transposon can trap and mutate endogenous transcripts in primordial germ cells. Finally, we observed that modified primordial germ cells form functional gametes as demonstrated by the generation of transgenic offspring that correctly expressed a reporter gene carried in the transposon. Transposable elements are therefore efficient vectors for the genetic manipulation of primordial germ cells and the chicken genome.

  6. Peptide nucleic acid (PNA): A model structure for the primordial genetic material?

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    Nielsen, Peter Egil

    1993-12-01

    It is proposed that the primordial genetic material could have been peptide nucleic aicds,i.e., DNA analogues having a peptide backbone. PNA momomers based on the amino acid, α, γ-diaminobutyric acid or ornithine are suggested as compounds that could have been formed in the prebiotic soup. Finally, the possibility of a PNA/RNA world is presented, in which PNA constitutes the stable genetic material, while RNA which may be polymerized using the PNA as template accounts for enzymatic activities including PNA replication.

  7. Computational and genetic reduction of a cell cycle to its simplest, primordial components.

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    Seán M Murray

    2013-12-01

    Full Text Available What are the minimal requirements to sustain an asymmetric cell cycle? Here we use mathematical modelling and forward genetics to reduce an asymmetric cell cycle to its simplest, primordial components. In the Alphaproteobacterium Caulobacter crescentus, cell cycle progression is believed to be controlled by a cyclical genetic circuit comprising four essential master regulators. Unexpectedly, our in silico modelling predicted that one of these regulators, GcrA, is in fact dispensable. We confirmed this experimentally, finding that ΔgcrA cells are viable, but slow-growing and elongated, with the latter mostly due to an insufficiency of a key cell division protein. Furthermore, suppressor analysis showed that another cell cycle regulator, the methyltransferase CcrM, is similarly dispensable with simultaneous gcrA/ccrM disruption ameliorating the cytokinetic and growth defect of ΔgcrA cells. Within the Alphaproteobacteria, gcrA and ccrM are consistently present or absent together, rather than either gene being present alone, suggesting that gcrA/ccrM constitutes an independent, dispensable genetic module. Together our approaches unveil the essential elements of a primordial asymmetric cell cycle that should help illuminate more complex cell cycles.

  8. Molecular genetics: DNA analysis of a putative dog clone.

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    Parker, Heidi G; Kruglyak, Leonid; Ostrander, Elaine A

    2006-03-09

    In August 2005, Lee et al. reported the first cloning of a domestic dog from adult somatic cells. This putative dog clone was the result of somatic-cell nuclear transfer from a fibroblast cell of a three-year-old male Afghan hound into a donor oocyte provided by a dog of mixed breed. In light of recent concerns regarding the creation of cloned human cell lines from the same institution, we have undertaken an independent test to determine the validity of the claims made by Lee et al..

  9. Primordial dwarfism: an update.

    Science.gov (United States)

    Alkuraya, Fowzan S

    2015-02-01

    To review the recent advances in the clinical and molecular characterization of primordial dwarfism, an extreme growth deficiency disorder that has its onset during embryonic development and persists throughout life. The last decade has witnessed an unprecedented acceleration in the discovery of genes mutated in primordial dwarfism, from one gene to more than a dozen genes. These genetic discoveries have confirmed the notion that primordial dwarfism is caused by defects in basic cellular processes, most notably centriolar biology and DNA damage response. Fortunately, the increasing number of reported clinical primordial dwarfism subtypes has been accompanied by more accurate molecular classification. Qualitative defects of centrioles with resulting abnormal mitosis dynamics, reduced proliferation, and increased apoptosis represent the predominant molecular pathogenic mechanism in primordial dwarfism. Impaired DNA damage response is another important mechanism, which we now know is not mutually exclusive to abnormal centrioles. Molecular characterization of primordial dwarfism is helping families by enabling more reproductive choices and may pave the way for the future development of therapeutics.

  10. Directed evolution of a model primordial enzyme provides insights into the development of the genetic code.

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    Manuel M Müller

    Full Text Available The contemporary proteinogenic repertoire contains 20 amino acids with diverse functional groups and side chain geometries. Primordial proteins, in contrast, were presumably constructed from a subset of these building blocks. Subsequent expansion of the proteinogenic alphabet would have enhanced their capabilities, fostering the metabolic prowess and organismal fitness of early living systems. While the addition of amino acids bearing innovative functional groups directly enhances the chemical repertoire of proteomes, the inclusion of chemically redundant monomers is difficult to rationalize. Here, we studied how a simplified chorismate mutase evolves upon expanding its amino acid alphabet from nine to potentially 20 letters. Continuous evolution provided an enhanced enzyme variant that has only two point mutations, both of which extend the alphabet and jointly improve protein stability by >4 kcal/mol and catalytic activity tenfold. The same, seemingly innocuous substitutions (Ile→Thr, Leu→Val occurred in several independent evolutionary trajectories. The increase in fitness they confer indicates that building blocks with very similar side chain structures are highly beneficial for fine-tuning protein structure and function.

  11. Transcriptome outlier analysis implicates schizophrenia susceptibility genes and enriches putatively functional rare genetic variants.

    Science.gov (United States)

    Duan, Jubao; Sanders, Alan R; Moy, Winton; Drigalenko, Eugene I; Brown, Eric C; Freda, Jessica; Leites, Catherine; Göring, Harald H H; Gejman, Pablo V

    2015-08-15

    We searched a gene expression dataset comprised of 634 schizophrenia (SZ) cases and 713 controls for expression outliers (i.e., extreme tails of the distribution of transcript expression values) with SZ cases overrepresented compared with controls. These outlier genes were enriched for brain expression and for genes known to be associated with neurodevelopmental disorders. SZ cases showed higher outlier burden (i.e., total outlier events per subject) than controls for genes within copy number variants (CNVs) associated with SZ or neurodevelopmental disorders. Outlier genes were enriched for CNVs and for rare putative regulatory variants, but this only explained a small proportion of the outlier subjects, highlighting the underlying presence of additional genetic and potentially, epigenetic mechanisms.

  12. Chromosomal radiosensitivity in breast cancer patients with a known or putative genetic predisposition.

    LENUS (Irish Health Repository)

    Baeyens, A

    2002-12-02

    The chromosomal radiosensitivity of breast cancer patients with a known or putative genetic predisposition was investigated and compared to a group of healthy women. The chromosomal radiosensitivity was assessed with the G2 and the G0-micronucleus assay. For the G2 assay lymphocytes were irradiated in vitro with a dose of 0.4 Gy (60)Co gamma-rays after 71 h incubation, and chromatid breaks were scored in 50 metaphases. For the micronucleus assay lymphocytes were exposed in vitro to 3.5 Gy (60)Co gamma-rays at a high dose rate or low dose rate. 70 h post-irradiation cultures were arrested and micronuclei were scored in 1000 binucleate cells. The results demonstrated that the group of breast cancer patients with a known or putative genetic predisposition was on the average more radiosensitive than a population of healthy women, and this with the G2 as well as with the high dose rate and low dose rate micronucleus assay. With the G2 assay 43% of the patients were found to be radiosensitive. A higher proportion of the patients were radiosensitive with the micronucleus assay (45% with high dose rate and 61% with low dose rate). No correlation was found between the G2 and the G0-micronucleus chromosomal radiosensitivity. Out of the different subgroups considered, the group of the young breast cancer patients without family history showed the highest percentage of radiosensitive cases in the G2 (50%) as well as in the micronucleus assay (75-78%).

  13. Genetic profiling of putative breast cancer stem cells from malignant pleural effusions.

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    Tiran, Verena; Stanzer, Stefanie; Heitzer, Ellen; Meilinger, Michael; Rossmann, Christopher; Lax, Sigurd; Tsybrovskyy, Oleksiy; Dandachi, Nadia; Balic, Marija

    2017-01-01

    A common symptom during late stage breast cancer disease is pleural effusion, which is related to poor prognosis. Malignant cells can be detected in pleural effusions indicating metastatic spread from the primary tumor site. Pleural effusions have been shown to be a useful source for studying metastasis and for isolating cells with putative cancer stem cell (CSC) properties. For the present study, pleural effusion aspirates from 17 metastatic breast cancer patients were processed to propagate CSCs in vitro. Patient-derived aspirates were cultured under sphere forming conditions and isolated primary cultures were further sorted for cancer stem cell subpopulations ALDH1+ and CD44+CD24-/low. Additionally, sphere forming efficiency of CSC and non-CSC subpopulations was determined. In order to genetically characterize the different tumor subpopulations, DNA was isolated from pleural effusions before and after cell sorting, and compared with corresponding DNA copy number profiles from primary tumors or bone metastasis using low-coverage whole genome sequencing (SCNA-seq). In general, unsorted cells had a higher potential to form spheres when compared to CSC subpopulations. In most cases, cell sorting did not yield sufficient cells for copy number analysis. A total of five from nine analyzed unsorted pleura samples (55%) showed aberrant copy number profiles similar to the respective primary tumor. However, most sorted subpopulations showed a balanced profile indicating an insufficient amount of tumor cells and low sensitivity of the sequencing method. Finally, we were able to establish a long term cell culture from one pleural effusion sample, which was characterized in detail. In conclusion, we confirm that pleural effusions are a suitable source for enrichment of putative CSC. However, sequencing based molecular characterization is impeded due to insufficient sensitivity along with a high number of normal contaminating cells, which are masking genetic alterations of

  14. Can Genetic Analysis of Putative Blood Alzheimer's Disease Biomarkers Lead to Identification of Susceptibility Loci?

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    Robert C Barber

    Full Text Available Although 24 Alzheimer's disease (AD risk loci have been reliably identified, a large portion of the predicted heritability for AD remains unexplained. It is expected that additional loci of small effect will be identified with an increased sample size. However, the cost of a significant increase in Case-Control sample size is prohibitive. The current study tests whether exploring the genetic basis of endophenotypes, in this case based on putative blood biomarkers for AD, can accelerate the identification of susceptibility loci using modest sample sizes. Each endophenotype was used as the outcome variable in an independent GWAS. Endophenotypes were based on circulating concentrations of proteins that contributed significantly to a published blood-based predictive algorithm for AD. Endophenotypes included Monocyte Chemoattractant Protein 1 (MCP1, Vascular Cell Adhesion Molecule 1 (VCAM1, Pancreatic Polypeptide (PP, Beta2 Microglobulin (B2M, Factor VII (F7, Adiponectin (ADN and Tenascin C (TN-C. Across the seven endophenotypes, 47 SNPs were associated with outcome with a p-value ≤1x10(-7. Each signal was further characterized with respect to known genetic loci associated with AD. Signals for several endophenotypes were observed in the vicinity of CR1, MS4A6A/MS4A4E, PICALM, CLU, and PTK2B. The strongest signal was observed in association with Factor VII levels and was located within the F7 gene. Additional signals were observed in MAP3K13, ZNF320, ATP9B and TREM1. Conditional regression analyses suggested that the SNPs contributed to variation in protein concentration independent of AD status. The identification of two putatively novel AD loci (in the Factor VII and ATP9B genes, which have not been located in previous studies despite massive sample sizes, highlights the benefits of an endophenotypic approach for resolving the genetic basis for complex diseases. The coincidence of several of the endophenotypic signals with known AD loci may point

  15. Genetic diversity of donkey populations from the putative centers of domestication.

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    Rosenbom, S; Costa, V; Al-Araimi, N; Kefena, E; Abdel-Moneim, A S; Abdalla, M A; Bakhiet, A; Beja-Pereira, A

    2015-02-01

    Donkey domestication drastically changed ancient transport systems in Africa and Asia, enabling overland circulation of people and goods and influencing the organization of early cities and pastoral societies. Genetic studies based on mtDNA have pointed to the African wild ass as the most probable ancestor of the domestic donkey, but questions regarding its center of origin remain unanswered. Endeavoring to pinpoint the geographical origin of domestic donkey, we assessed levels and patterns of genetic diversity at 15 microsatellite loci from eight populations, representing its three hypothesized centers of origin: northeast Africa, the Near East and the Arabian Peninsula. Additionally, we compared the donkey genotypes with those from their wild relative, the African wild ass (Equus africanus somaliensis) to visualize patterns of differentiation among wild and domestic individuals. Obtained results revealed limited variation in levels of unbiased expected heterozygosity across populations in studied geographic regions (ranging from 0.637 in northeast Africa to 0.679 in the Near East). Both allelic richness (Ar) and private allelic richness presented considerably higher values in northeast Africa and in the Arabian Peninsula. By looking at variation at the country level, for each region, we were able to identify Sudan and Yemen as the countries possessing higher allelic richness and, cumulatively, Yemen also presented higher values for private allelic richness. Our results support previously proposed northeast Africa as a putative center of origin, but the high levels of unique diversity in Yemen opens the possibility of considering this region as yet another center of origin for this species.

  16. Primordial magnetogenesis

    CERN Document Server

    Kandus, Alejandra; Tsagas, Christos G

    2010-01-01

    Magnetic fields appear everywhere in the universe. From stars and galaxies, all the way to galaxy clusters and remote protogalactic clouds magnetic fields of considerable strength and size have been repeatedly observed. Despite their widespread presence, however, the origin of cosmic magnetic fields is still a mystery. The galactic dynamo is believed capable of amplifying weak magnetic seeds to strengths like those measured in ours and other galaxies, but the question is where do these seed fields come from? Are they a product of late, post-recombination, physics or are they truly cosmological in origin? The idea of primordial magnetism is attractive because it makes the large-scale magnetic fields, especially those found in early protogalactic systems, easier to explain. As a result, a host of different scenarios have appeared in the literature. Nevertheless, early magnetogenesis is not problem free, with a number of issues remaining open and a matter of debate. We review the question of primordial magnetic ...

  17. Primordial magnetogenesis

    Science.gov (United States)

    Kandus, Alejandra; Kunze, Kerstin E.; Tsagas, Christos G.

    2011-08-01

    Magnetic fields appear everywhere in the universe. From stars and galaxies, all the way to galaxy clusters and remote protogalactic clouds, magnetic fields of considerable strength and size have been repeatedly observed. Despite their widespread presence, however, the origin of cosmic magnetic fields is still a mystery. The galactic dynamo is believed capable of amplifying weak magnetic seeds to strengths like those measured in ours and other galaxies. But the question is where do these seed fields come from? Are they a product of late, post-recombination, physics or are they truly cosmological in origin? The idea of primordial magnetism is attractive because it makes the large-scale magnetic fields, especially those found in early protogalactic systems, easier to explain. As a result, a host of different scenarios have appeared in the literature. Nevertheless, early magnetogenesis is not problem-free, with a number of issues remaining open and a matter of debate. We review the question of the origin of primordial magnetic fields and consider the limits set on their strength by the current observational data. The various mechanisms of pre-recombination magnetogenesis are presented and their advantages and shortcomings are debated. We consider both classical and quantum scenarios, that operate within as well as outside the standard model, and also discuss how future observations could be used to decide whether the large-scale magnetic fields we see in the universe today are truly primordial or not.

  18. Primordial Nucleosynthesis

    CERN Document Server

    Coc, Alain

    2012-01-01

    Primordial nucleosynthesis, or Big-Bang Nucleosynthesis (BBN), is one of the three evidences for the Big-Bang model, together with the expansion of the Universe and the Cosmic Microwave Background. There is a good global agreement over a range of nine orders of magnitude between abundances of 4He, D, 3He and 7Li deduced from observations, and calculated in primordial nucleosynthesis. This comparison was used to determine the baryonic density of the Universe. For this purpose, it is now superseded by the analysis of the Cosmic Microwave Background (CMB) radiation anisotropies. However, there remain, a yet unexplained, discrepancy of a factor 3-5, between the calculated and observed lithium primordial abundances, that has not been reduced, neither by recent nuclear physics experiments, nor by new observations. We review here the nuclear physics aspects of BBN for the production of 4He, D, 3He and 7Li, but also 6Li, 9Be, 11B and up to CNO isotopes. These are, for instance, important for the initial composition o...

  19. Primordial Nucleosynthesis

    CERN Document Server

    Coc, Alain

    2016-01-01

    Primordial or big bang nucleosynthesis (BBN) is now a parameter free theory whose predictions are in good overall agreement with observations. However, the 7Li calculated abundance is significantly higher than the one deduced from spectroscopic observations. Most solutions to this lithium problem involve a source of extra neutrons that inevitably leads to an increase of the deuterium abundance. This seems now to be excluded by recent deuterium observations that have drastically reduced the uncertainty on D/H and also calls for improved precision on thermonuclear reaction rates.

  20. Genetic diversity of bovine papillomavirus types, including two putative new types, in teat warts from dairy cattle herds.

    Science.gov (United States)

    Lunardi, Michele; de Camargo Tozato, Claudia; Alfieri, Alice Fernandes; de Alcântara, Brígida Kussumoto; Vilas-Boas, Laurival Antonio; Otonel, Rodrigo Alejandro Arellano; Headley, Selwyn Arlington; Alfieri, Amauri Alcindo

    2016-06-01

    Teat papillomatosis affects dairy cows worldwide. Milking can become difficult due to teat warts, and maintaining affected cows in the herds may diminish economic profit in the dairy industry. Currently, 13 bovine papillomavirus (BPV) types have been fully characterized, and numerous putative BPV types have been identified through partial L1 gene PCR. In order to identify the viral types present in warts on the udders of dairy cows, 40 teat lesions from 24 cows from 13 cattle farms in three States of Brazil were evaluated by PV L1 gene PCR. The warts that were evaluated contained sequences from BPVs 6-10, the putative BPV types BAPV9 and BAPV4, and two unreported putative papillomavirus (PV) types, named BPV/BR-UEL6 and BPV/BR-UEL7. In addition, mixed infections and coinfections were identified, since more than one lesion was observed on the udders of 13 cows. Phylogenetic analysis showed that BPV/BR-UEL6 is closely related to BPVs belonging to the genus Xipapillomavirus, while BPV/BR-UEL7 clustered with the previously reported strains Cervus timorensis and Pudu puda PVs, which represent a putative new PV type, and it was only distantly related to xi-, epsilon-, delta- and dyoxi-PVs. These results provide information that will assist in the understanding of the association of BPVs 6, 7, 8, 9, and 10, as well as putative BPV types BAPV4 and BAPV9, with mammary papillomatosis. This is the first characterization of putative novel PV types BPV/BR-UEL6 and BPV/BR-UEL7 in teat warts of dairy cows, highlighting the high genetic diversity of BPVs associated with teat papillomatosis.

  1. Primordial Spirituality

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    Kees Waaijman

    2010-02-01

    Full Text Available This article explores the primordial spirituality of the Bible, as expressed in names, narratives and prayers. It looks at the nomadic families of Abraham and Sarah, Isaac and Rebecca, Jacob, Lea and Rachel, moving around from Mesopotamia via Canaan into Egypt and vice versa (see Gn 11:31–32; 12:4–5; 27:43; 28:10; 29:4; Gn 24 and 29–31. It analyses their experiences, covering the span between birth and death and listens to their parental concerns about education as survival. It also follows their journeys along the margins of the deserts. It shares their community life as it takes shape in mutual solidarity, mercy and compassion.

  2. Primordial nucleosynthesis

    Science.gov (United States)

    Gustavino, C.; Anders, M.; Bemmerer, D.; Elekes, Z.; Trezzi, D.

    2016-04-01

    Big Bang nucleosynthesis (BBN) describes the production of light nuclei in the early phases of the Universe. For this, precise knowledge of the cosmological parameters, such as the baryon density, as well as the cross section of the fusion reactions involved are needed. In general, the energies of interest for BBN are so low ( E Big Bang nucleosynthesis using protons, 3He and alpha particles as projectiles. The main reaction studied in the past at LUNA is the 2H(4He, γ)6Li . Its cross section was measured directly, for the first time, in the BBN energy range. Other processes like 2H(p, γ)3He , 3He(2H, p)4He and 3He(4He, γ)7Be were also studied at LUNA, thus enabling to reduce the uncertainty on the overall reaction rate and consequently on the determination of primordial abundances. The improvements on BBN due to the LUNA experimental data will be discussed and a perspective of future measurements will be outlined.

  3. Primordial nucleosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Gustavino, C. [INFN, Sezione di Roma La Sapienza, Roma (Italy); Anders, M. [Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany); Technische Universitaet Dresden, Dresden (Germany); Bemmerer, D. [Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany); Elekes, Z. [Institute for Nuclear Research of the Hungarian Academy of Sciences (MTA Atomki), Debrecen (Hungary); Trezzi, D. [Universita degli Studi di Milano (Italy); INFN, Milano (Italy)

    2016-04-15

    Big Bang nucleosynthesis (BBN) describes the production of light nuclei in the early phases of the Universe. For this, precise knowledge of the cosmological parameters, such as the baryon density, as well as the cross section of the fusion reactions involved are needed. In general, the energies of interest for BBN are so low (E < 1 MeV) that nuclear cross section measurements are practically unfeasible at the Earth's surface. As of today, LUNA (Laboratory for Underground Nuclear Astrophysics) has been the only facility in the world available to perform direct measurements of small cross section in a very low background radiation. Owing to the background suppression provided by about 1400 meters of rock at the Laboratori Nazionali del Gran Sasso (LNGS), Italy, and to the high current offered by the LUNA accelerator, it has been possible to investigate cross sections at energies of interest for Big Bang nucleosynthesis using protons, {sup 3}He and alpha particles as projectiles. The main reaction studied in the past at LUNA is the {sup 2}H({sup 4}He, γ){sup 6}Li. Its cross section was measured directly, for the first time, in the BBN energy range. Other processes like {sup 2}H(p, γ){sup 3}He, {sup 3}He({sup 2}H, p){sup 4}He and {sup 3}He({sup 4}He, γ){sup 7}Be were also studied at LUNA, thus enabling to reduce the uncertainty on the overall reaction rate and consequently on the determination of primordial abundances. The improvements on BBN due to the LUNA experimental data will be discussed and a perspective of future measurements will be outlined. (orig.)

  4. Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome

    DEFF Research Database (Denmark)

    Lohmueller, Kirk E; Albrechtsen, Anders; Li, Yingrui;

    2011-01-01

    throughout the genome. Further, we show that the widespread presence of weakly deleterious alleles, rather than a small number of strongly positively selected mutations, is responsible for the correlation between neutral genetic diversity and recombination rate. This work suggests that natural selection has......A major question in evolutionary biology is how natural selection has shaped patterns of genetic variation across the human genome. Previous work has documented a reduction in genetic diversity in regions of the genome with low recombination rates. However, it is unclear whether other summaries...... and that human diversity, human-chimp divergence, and average minor allele frequency are reduced near genes. Population genetic simulations show that either positive natural selection acting on favorable mutations or negative natural selection acting against deleterious mutations can explain these correlations...

  5. Genetic analysis of BIRC4/XIAP as a putative modifier gene of Wilson disease.

    Science.gov (United States)

    Weiss, Karl Heinz; Runz, Heiko; Noe, Barbara; Gotthardt, Daniel Nils; Merle, Uta; Ferenci, Peter; Stremmel, Wolfgang; Füllekrug, Joachim

    2010-12-01

    Wilson disease (WD) is an autosomal-recessive copper overload disorder caused by mutations in the copper-transporting adenosine triphosphatase (ATPase) ATP7B. It presents with a highly variable clinical phenotype ranging from asymptomatic to fulminant hepatic failure or progressive neurological involvement. No clear genotype-phenotype correlation has been established. Thus, variants in modifier genes could have an impact on WD manifestation and severity. Recently, the antiapoptotic protein baculoviral IAP repeat-containing protein 4 BIRC4/XIAP has been suggested as a regulator of copper-induced cell death. With the aim of investigating a putative role of BIRC4/XIAP as modifier gene in individuals with copper overload, we analyzed a WD patient cohort (n = 98) for sequence variants at the BIRC4/XIAP locus. When compared with clinical data, the previously described coding single nucleotide polymorphisms (SNPs) at the BRIC4/XIAP locus (rs28382721, rs28382722, rs28382723, rs5956583, rs28382740, rs12838858, rs28382741) did not correlate with age of onset or clinical presentation in our collective. However, three previously unreported variants in the BIRC4/XIAP gene were identified (c.1-26 T > G; c.1408A > T; p.T470S; c.1019A > G; p.N340S). The two patients with variants leading to amino acid exchanges in the BIRC4/XIAP protein showed a remarkably early disease onset at the age of 5 years. Furthermore, one of these patients was only heterozygous for disease-causing mutations in the ATP7B gene. In summary, these data emphasize the need to further elucidate a role of BIRC4/XIAP variants as putative pathogenetic factors in copper overload disorders.

  6. Genetic structure and evidence of putative Darwinian diversifying selection in the Potato yellow vein virus (PYVV

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    Giovanni Chaves-Bedoya

    2013-08-01

    Full Text Available The population structure and genetic variation of Potato yellow vein virus (PYVV were estimated by analysis of the nucleotide and deduced amino acid sequence of the coat protein of 69 isolates, reported in GenBank, from Solanum tuberosum (ST and Solanum phureja (SP hosts from different regions; predominantly Cundinamarca, Antioquia and Nariño, located in central and southwestern Colombia. Bioinformatics analysis revealed that despite the wide geographic distribution of different hosts and different collecting years, PYVV maintains a genetic similarity between 97.1 to 100.0%, indicating high spatial and temporal genetic stability of the major coat protein. No recombination events were found, but evidence was seen for the first time that this protein could be undergoing Darwinian diversifying selection

  7. Natural selection affects multiple aspects of genetic variation at putatively peutral sites across the human genome

    DEFF Research Database (Denmark)

    Lohmueller, Kirk E; Albrechtsen, Anders; Li, Yingrui

    2011-01-01

    A major question in evolutionary biology is how natural selection has shaped patterns of genetic variation across the human genome. Previous work has documented a reduction in genetic diversity in regions of the genome with low recombination rates. However, it is unclear whether other summaries...... affected multiple aspects of linked neutral variation throughout the human genome and that positive selection is not required to explain these observations....... these questions by analyzing three different genome-wide resequencing datasets from European individuals. We document several significant correlations between different genomic features. In particular, we find that average minor allele frequency and diversity are reduced in regions of low recombination...

  8. Genetic and genomic diversity studies of Acacia symbionts in Senegal reveal new species of Mesorhizobium with a putative geographical pattern.

    Directory of Open Access Journals (Sweden)

    Fatou Diouf

    Full Text Available Acacia senegal (L Willd. and Acacia seyal Del. are highly nitrogen-fixing and moderately salt tolerant species. In this study we focused on the genetic and genomic diversity of Acacia mesorhizobia symbionts from diverse origins in Senegal and investigated possible correlations between the genetic diversity of the strains, their soil of origin, and their tolerance to salinity. We first performed a multi-locus sequence analysis on five markers gene fragments on a collection of 47 mesorhizobia strains of A. senegal and A. seyal from 8 localities. Most of the strains (60% clustered with the M. plurifarium type strain ORS 1032T, while the others form four new clades (MSP1 to MSP4. We sequenced and assembled seven draft genomes: four in the M. plurifarium clade (ORS3356, ORS3365, STM8773 and ORS1032T, one in MSP1 (STM8789, MSP2 (ORS3359 and MSP3 (ORS3324. The average nucleotide identities between these genomes together with the MLSA analysis reveal three new species of Mesorhizobium. A great variability of salt tolerance was found among the strains with a lack of correlation between the genetic diversity of mesorhizobia, their salt tolerance and the soils samples characteristics. A putative geographical pattern of A. senegal symbionts between the dryland north part and the center of Senegal was found, reflecting adaptations to specific local conditions such as the water regime. However, the presence of salt does not seem to be an important structuring factor of Mesorhizobium species.

  9. Genetic and genomic diversity studies of Acacia symbionts in Senegal reveal new species of Mesorhizobium with a putative geographical pattern.

    Science.gov (United States)

    Diouf, Fatou; Diouf, Diegane; Klonowska, Agnieszka; Le Queré, Antoine; Bakhoum, Niokhor; Fall, Dioumacor; Neyra, Marc; Parrinello, Hugues; Diouf, Mayecor; Ndoye, Ibrahima; Moulin, Lionel

    2015-01-01

    Acacia senegal (L) Willd. and Acacia seyal Del. are highly nitrogen-fixing and moderately salt tolerant species. In this study we focused on the genetic and genomic diversity of Acacia mesorhizobia symbionts from diverse origins in Senegal and investigated possible correlations between the genetic diversity of the strains, their soil of origin, and their tolerance to salinity. We first performed a multi-locus sequence analysis on five markers gene fragments on a collection of 47 mesorhizobia strains of A. senegal and A. seyal from 8 localities. Most of the strains (60%) clustered with the M. plurifarium type strain ORS 1032T, while the others form four new clades (MSP1 to MSP4). We sequenced and assembled seven draft genomes: four in the M. plurifarium clade (ORS3356, ORS3365, STM8773 and ORS1032T), one in MSP1 (STM8789), MSP2 (ORS3359) and MSP3 (ORS3324). The average nucleotide identities between these genomes together with the MLSA analysis reveal three new species of Mesorhizobium. A great variability of salt tolerance was found among the strains with a lack of correlation between the genetic diversity of mesorhizobia, their salt tolerance and the soils samples characteristics. A putative geographical pattern of A. senegal symbionts between the dryland north part and the center of Senegal was found, reflecting adaptations to specific local conditions such as the water regime. However, the presence of salt does not seem to be an important structuring factor of Mesorhizobium species.

  10. Genetic variation in eastern North American and putatively introduced populations of Ceratocystis fimbriata f. platani.

    Science.gov (United States)

    Engelbrecht, C J B; Harrington, T C; Steimel, J; Capretti, P

    2004-10-01

    The plant pathogenic fungus Ceratocystis fimbriata f. platani attacks Platanus species (London plane, oriental plane and American sycamore) and has killed tens of thousands of plantation trees and street trees in the eastern United States, southern Europe and Modesto, California. Nuclear and mitochondrial DNA fingerprints and alleles of eight polymorphic microsatellite markers of isolates of C. fimbriata from these regions delineated major differences in gene diversities. The 33 isolates from the eastern United States had a moderate degree of gene diversity, and unique genotypes were found at each of seven collection sites. Fingerprints of 27 isolates from 21 collection sites in southern Europe were identical with each other; microsatellite markers were monomorphic within the European population, except that three isolates differed at one locus each, due perhaps to recent mutations. The genetic variability of C. fimbriata f. platani in the eastern United States suggests that the fungus is indigenous to this region. The genetic homogeneity of the fungus in Europe suggests that this population has gone through a recent genetic bottleneck, perhaps from the introduction of a single genotype. This supports the hypothesis that the pathogen was introduced to Europe through Naples, Italy during World War II on infected crating material from the eastern United States. The Californian population may also have resulted from introduction of one or a few related genotypes because it, too, had a single nuclear and mitochondrial genotype and limited variation in microsatellite alleles.

  11. Genetic identification of putative remains of the famous astronomer Nicolaus Copernicus.

    Science.gov (United States)

    Bogdanowicz, Wiesław; Allen, Marie; Branicki, Wojciech; Lembring, Maria; Gajewska, Marta; Kupiec, Tomasz

    2009-07-28

    We report the results of mitochondrial and nuclear DNA analyses of skeletal remains exhumed in 2005 at Frombork Cathedral in Poland, that are thought to be those of Nicolaus Copernicus (1473-1543). The analyzed bone remains were found close to the altar Nicolaus Copernicus was responsible for during his tenure as priest. The mitochondrial DNA (mtDNA) profiles from 3 upper molars and the femurs were identical, suggesting that the remains originate from the same individual. Identical mtDNA profiles were also determined in 2 hairs discovered in a calendar now exhibited at Museum Gustavianum in Uppsala, Sweden. This calendar was the property of Nicolaus Copernicus for much of his life. These findings, together with anthropological data, support the identification of the human remains found in Frombork Cathedral as those of Nicolaus Copernicus. Up-to-now the particular mtDNA haplotype has been observed only 3 times in Germany and once in Denmark. Moreover, Y-chromosomal and autosomal short tandem repeat markers were analyzed in one of the tooth samples, that was much better preserved than other parts of the skeleton. Molecular sex determination revealed that the skeleton is from a male individual, and this result is consistent with morphological investigations. The minimal Y-chromosomal haplotype determined in the putative remains of Nicolaus Copernicus has been observed previously in many countries, including Austria, Germany, Poland, and the Czech Republic. Finally, an analysis of the SNP located in the HERC2 gene revealed the C/C genotype that is predominant in blue-eyed humans, suggesting that Copernicus may have had a light iris color.

  12. Direct Reprogramming of Human Primordial Germ Cells into Induced Pluripotent Stem Cells: Efficient Generation of Genetically Engineered Germ Cells.

    Science.gov (United States)

    Bazley, Faith A; Liu, Cyndi F; Yuan, Xuan; Hao, Haiping; All, Angelo H; De Los Angeles, Alejandro; Zambidis, Elias T; Gearhart, John D; Kerr, Candace L

    2015-11-15

    Primordial germ cells (PGCs) share many properties with embryonic stem cells (ESCs) and innately express several key pluripotency-controlling factors, including OCT4, NANOG, and LIN28. Therefore, PGCs may provide a simple and efficient model for studying somatic cell reprogramming to induced pluripotent stem cells (iPSCs), especially in determining the regulatory mechanisms that fundamentally define pluripotency. Here, we report a novel model of PGC reprogramming to generate iPSCs via transfection with SOX2 and OCT4 using integrative lentiviral. We also show the feasibility of using nonintegrative approaches for generating iPSC from PGCs using only these two factors. We show that human PGCs express endogenous levels of KLF4 and C-MYC protein at levels similar to embryonic germ cells (EGCs) but lower levels of SOX2 and OCT4. Transfection with both SOX2 and OCT4 together was required to induce PGCs to a pluripotent state at an efficiency of 1.71%, and the further addition of C-MYC increased the efficiency to 2.33%. Immunohistochemical analyses of the SO-derived PGC-iPSCs revealed that these cells were more similar to ESCs than EGCs regarding both colony morphology and molecular characterization. Although leukemia inhibitory factor (LIF) was not required for the generation of PGC-iPSCs like EGCs, the presence of LIF combined with ectopic exposure to C-MYC yielded higher efficiencies. Additionally, the SO-derived PGC-iPSCs exhibited differentiation into representative cell types from all three germ layers in vitro and successfully formed teratomas in vivo. Several lines were generated that were karyotypically stable for up to 24 subcultures. Their derivation efficiency and survival in culture significantly supersedes that of EGCs, demonstrating their utility as a powerful model for studying factors regulating pluripotency in future studies.

  13. Purging putative siblings from population genetic data sets: a cautionary view.

    Science.gov (United States)

    Waples, Robin S; Anderson, Eric C

    2017-03-01

    Interest has surged recently in removing siblings from population genetic data sets before conducting downstream analyses. However, even if the pedigree is inferred correctly, this has the potential to do more harm than good. We used computer simulations and empirical samples of coho salmon to evaluate strategies for adjusting samples to account for family structure. We compared performance in full samples and sibling-reduced samples of estimators of allele frequency (P^), population differentiation (F^ST) and effective population size (N^e).

  14. Genetic Characterization of Plasmodium Putative Pantothenate Kinase Genes Reveals Their Essential Role in Malaria Parasite Transmission to the Mosquito.

    Science.gov (United States)

    Hart, Robert J; Cornillot, Emmanuel; Abraham, Amanah; Molina, Emily; Nation, Catherine S; Ben Mamoun, Choukri; Aly, Ahmed S I

    2016-09-20

    The metabolic machinery for the biosynthesis of Coenzyme A (CoA) from exogenous pantothenic acid (Vitamin B5) has long been considered as an excellent target for the development of selective antimicrobials. Earlier studies in the human malaria parasite Plasmodium falciparum have shown that pantothenate analogs interfere with pantothenate phosphorylation and block asexual blood stage development. Although two eukaryotic-type putative pantothenate kinase genes (PanK1 and PanK2) have been identified in all malaria parasite species, their role in the development of Plasmodium life cycle stages remains unknown. Here we report on the genetic characterization of PanK1 and PanK2 in P. yoelii. We show that P. yoelii parasites lacking either PanK1 or PanK2 undergo normal asexual stages development and sexual stages differentiation, however they are severely deficient in ookinete, oocyst and sporozoite formation inside the mosquito vector. Quantitative transcriptional analyses in wild-type and knockout parasites demonstrate an important role for these genes in the regulation of expression of other CoA biosynthesis genes. Together, our data provide the first genetic evidence for the importance of the early steps of pantothenate utilization in the regulation of CoA biosynthesis and malaria parasite transmission to Anopheles mosquitoes.

  15. Genetic Characterization of Plasmodium Putative Pantothenate Kinase Genes Reveals Their Essential Role in Malaria Parasite Transmission to the Mosquito

    Science.gov (United States)

    Hart, Robert J.; Cornillot, Emmanuel; Abraham, Amanah; Molina, Emily; Nation, Catherine S.; Ben Mamoun, Choukri; Aly, Ahmed S. I.

    2016-01-01

    The metabolic machinery for the biosynthesis of Coenzyme A (CoA) from exogenous pantothenic acid (Vitamin B5) has long been considered as an excellent target for the development of selective antimicrobials. Earlier studies in the human malaria parasite Plasmodium falciparum have shown that pantothenate analogs interfere with pantothenate phosphorylation and block asexual blood stage development. Although two eukaryotic-type putative pantothenate kinase genes (PanK1 and PanK2) have been identified in all malaria parasite species, their role in the development of Plasmodium life cycle stages remains unknown. Here we report on the genetic characterization of PanK1 and PanK2 in P. yoelii. We show that P. yoelii parasites lacking either PanK1 or PanK2 undergo normal asexual stages development and sexual stages differentiation, however they are severely deficient in ookinete, oocyst and sporozoite formation inside the mosquito vector. Quantitative transcriptional analyses in wild-type and knockout parasites demonstrate an important role for these genes in the regulation of expression of other CoA biosynthesis genes. Together, our data provide the first genetic evidence for the importance of the early steps of pantothenate utilization in the regulation of CoA biosynthesis and malaria parasite transmission to Anopheles mosquitoes. PMID:27644319

  16. Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers

    Directory of Open Access Journals (Sweden)

    Luo Hongmei

    2011-12-01

    -generation sequencing (NGS technology. The candidate genes involved in triterpene saponin biosynthesis, including the putative CYP450s and UGTs, were obtained in this study. Additionally, the identification of SSRs provided plenty of genetic makers for molecular breeding and genetics applications in this species. These data will provide information on gene discovery, transcriptional regulation and marker-assisted selection for P. notoginseng. The dataset establishes an important foundation for the study with the purpose of ensuring adequate drug resources for this species.

  17. Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the Chicken

    Directory of Open Access Journals (Sweden)

    Martin Johnsson

    2016-02-01

    Full Text Available Life history traits such as fecundity are important to evolution because they make up components of lifetime fitness. Due to their polygenic architectures, such traits are difficult to investigate with genetic mapping. Therefore, little is known about their molecular basis. One possible way toward finding the underlying genes is to map intermediary molecular phenotypes, such as gene expression traits. We set out to map candidate quantitative trait genes for egg fecundity in the chicken by combining quantitative trait locus mapping in an advanced intercross of wild by domestic chickens with expression quantitative trait locus mapping in the same birds. We measured individual egg fecundity in 232 intercross chickens in two consecutive trials, the second one aimed at measuring brooding. We found 12 loci for different aspects of egg fecundity. We then combined the genomic confidence intervals of these loci with expression quantitative trait loci from bone and hypothalamus in the same intercross. Overlaps between egg loci and expression loci, and trait–gene expression correlations identify 29 candidates from bone and five from hypothalamus. The candidate quantitative trait genes include fibroblast growth factor 1, and mitochondrial ribosomal proteins L42 and L32. In summary, we found putative quantitative trait genes for egg traits in the chicken that may have been affected by regulatory variants under chicken domestication. These represent, to the best of our knowledge, some of the first candidate genes identified by genome-wide mapping for life history traits in an avian species.

  18. Quantitative Trait Locus and Genetical Genomics Analysis Identifies Putatively Causal Genes for Fecundity and Brooding in the Chicken.

    Science.gov (United States)

    Johnsson, Martin; Jonsson, Kenneth B; Andersson, Leif; Jensen, Per; Wright, Dominic

    2015-12-04

    Life history traits such as fecundity are important to evolution because they make up components of lifetime fitness. Due to their polygenic architectures, such traits are difficult to investigate with genetic mapping. Therefore, little is known about their molecular basis. One possible way toward finding the underlying genes is to map intermediary molecular phenotypes, such as gene expression traits. We set out to map candidate quantitative trait genes for egg fecundity in the chicken by combining quantitative trait locus mapping in an advanced intercross of wild by domestic chickens with expression quantitative trait locus mapping in the same birds. We measured individual egg fecundity in 232 intercross chickens in two consecutive trials, the second one aimed at measuring brooding. We found 12 loci for different aspects of egg fecundity. We then combined the genomic confidence intervals of these loci with expression quantitative trait loci from bone and hypothalamus in the same intercross. Overlaps between egg loci and expression loci, and trait-gene expression correlations identify 29 candidates from bone and five from hypothalamus. The candidate quantitative trait genes include fibroblast growth factor 1, and mitochondrial ribosomal proteins L42 and L32. In summary, we found putative quantitative trait genes for egg traits in the chicken that may have been affected by regulatory variants under chicken domestication. These represent, to the best of our knowledge, some of the first candidate genes identified by genome-wide mapping for life history traits in an avian species.

  19. Transcriptome analysis of Panax vietnamensis var. fuscidicus discovers putative ocotillol-type ginsenosides biosynthesis genes and genetic markers.

    Science.gov (United States)

    Zhang, Guang-Hui; Ma, Chun-Hua; Zhang, Jia-Jin; Chen, Jun-Wen; Tang, Qing-Yan; He, Mu-Han; Xu, Xiang-Zeng; Jiang, Ni-Hao; Yang, Sheng-Chao

    2015-03-08

    liquid chromatography (HPLC) and evaporative light scattering detector (ELSD). The genomic resources generated from P. vietnamensis var. fuscidiscus provide new insights into the identification of putative genes involved in triterpenoid saponins biosynthesis pathway. This will facilitate our understanding of the biosynthesis of triterpenoid saponins at molecular level. The SSR markers identified and developed in this study show genetic diversity for this important crop and will contribute to marker-assisted breeding for P. vietnamensis var. fuscidiscus.

  20. The dynamics of the primordial follicle reserve.

    Science.gov (United States)

    Kerr, Jeffrey B; Myers, Michelle; Anderson, Richard A

    2013-12-01

    The female germline comprises a reserve population of primordial (non-growing) follicles containing diplotene oocytes arrested in the first meiotic prophase. By convention, the reserve is established when all individual oocytes are enclosed by granulosa cells. This commonly occurs prior to or around birth, according to species. Histologically, the 'reserve' is the number of primordial follicles in the ovary at any given age and is ultimately depleted by degeneration and progression through folliculogenesis until exhausted. How and when the reserve reaches its peak number of follicles is determined by ovarian morphogenesis and germ cell dynamics involving i) oogonial proliferation and entry into meiosis producing an oversupply of oocytes and ii) large-scale germ cell death resulting in markedly reduced numbers surviving as the primordial follicle reserve. Our understanding of the processes maintaining the reserve comes primarily from genetically engineered mouse models, experimental activation or destruction of oocytes, and quantitative histological analysis. As the source of ovulated oocytes in postnatal life, the primordial follicle reserve requires regulation of i) its survival or maintenance, ii) suppression of development (dormancy), and iii) activation for growth and entry into folliculogenesis. The mechanisms influencing these alternate and complex inter-related phenomena remain to be fully elucidated. Drawing upon direct and indirect evidence, we discuss the controversial concept of postnatal oogenesis. This posits a rare population of oogonial stem cells that contribute new oocytes to partially compensate for the age-related decline in the primordial follicle reserve.

  1. Primordial Black Hole Baryogenesis

    CERN Document Server

    Baumann, D; Turok, N G; Baumann, Daniel; Steinhardt, Paul J.; Turok, Neil

    2007-01-01

    We reconsider the possibility that the observed baryon asymmetry was generated by the evaporation of primordial black holes that dominated the early universe. We present a simple derivation showing that the baryon asymmetry is insensitive to the initial black hole density and the cosmological model but is sensitive to the temperature-dependence of the CP and baryon-violating (or lepton-violating) interactions. We also consider the possibility that black holes stop evaporating and form Planck-mass remnants that act as dark matter. We show that primordial black holes cannot simultaneously account for both the observed baryon asymmetry and the (remnant) dark matter density unless the magnitude of CP violation is much greater than expected from most particle physics models. Finally, we apply these results to ekpyrotic/cyclic models, in which primordial black holes may form when branes collide. We find that obtaining the observed baryon asymmetry is compatible with the other known constraints on parameters.

  2. Primordial Planet Formation

    CERN Document Server

    Schild, Rudolph E

    2010-01-01

    Recent spacecraft observations exploring solar system properties impact standard paradigms of the formation of stars, planets and comets. We stress the unexpected cloud of microscopic dust resulting from the DEEP IMPACT mission, and the existence of molten nodules in STARDUST samples. And the theory of star formation does not explain the common occurrence of binary and multiple star systems in the standard gas fragmentation scenario. No current theory of planet formation can explain the iron core of the earth, under oceans of water. These difficulties are avoided in a scenario where the planet mass objects form primordially and are today the baryonic dark matter. They have been detected in quasar microlensing and anomalous quasar radio brightening bursts. The primordial planets often concentrate together to form a star, with residual matter seen in pre-stellar accretion discs around the youngest stars. These primordial planet mass bodies were formed of hydrogen-helium, aggregated in dense clumps of a trillion...

  3. [Signaling molecules and pathways involved in maintaining the quiescence of primordial follicles].

    Science.gov (United States)

    Hu, Liao-Liao; Xiang, Cheng; Zheng, Li-Ping

    2015-02-25

    Reproductive lifespan in female mammals is related to the size of primordial follicles pool, which relies on the balance between activated and quiescent primordial follicles. Therefore, the molecular mechanisms of recruiting and maintaining quiescence of primordial follicles have become hot research topics recently. Multiple studies have shown that genetic mutations, local ovarian autocrine and paracrine factors, proto-oncogene and tumor-suppressor genes are involved in the maintenance of balance between quiescent and activated primordial follicles. In the present review, we summarize recent research progress of the important signaling molecules and pathways that maintain the quiescence of primordial follicles.

  4. Combining geometric morphometrics with molecular genetics to investigate a putative hybrid complex: a case study with barbels Barbus spp. (Teleostei: Cyprinidae).

    Science.gov (United States)

    Geiger, M F; Schreiner, C; Delmastro, G B; Herder, F

    2016-03-01

    This integrative study examined the morphological and genetic affinities of three endemic barbel species from Italy (brook barbel Barbus caninus, Italian barbel Barbus plebejus and horse barbel Barbus tyberinus) and of putative hybrid specimens to their species of origin. Two of the species frequently occur together with the non-native barbel Barbus barbus. DNA barcoding indicates that mitochondrial (mt) haplotypes often do not match the species expected from morphology. Linear distance measurements and meristics are not informative for discrimination of the species and putative hybrids, but a discriminant analysis of principal components (DAPC) of geometric landmark data produces reassignments largely in congruence with mt and nuclear genetic data. Cyto-nuclear conflicts confirm the presence of hybridization in B. plebejus and B. tyberinus and identify additional introgressed specimens. A comparison between mixed genotypes and their morphology-based assignment reveals no predictable pattern. The finding that most individuals of the morphologically similar B. plebejus and B. tyberinus have very high assignment probabilities to their respective species suggests that the presented approach may serve as a valuable tool to distinguish morphologically very similar taxa.

  5. The Primordial Inflation Explorer

    Science.gov (United States)

    Kogut, Alan J.

    2012-01-01

    The Primordial Inflation Explorer is an Explorer-class mission to measure the gravity-wave signature of primordial inflation through its distinctive imprint on the linear polarization of the cosmic microwave background. PIXIE uses an innovative optical design to achieve background-limited sensitivity in 400 spectral channels spanning 2.5 decades in frequency from 30 GHz to 6 THz (1 cm to 50 micron wavelength). The principal science goal is the detection and characterization of linear polarization from an inflationary epoch in the early universe, with tensor-to-scalar ratio r < 10(exp -3) at 5 standard deviations. The rich PIXIE data set will also constrain physical processes ranging from Big Bang cosmology to the nature of the first stars to physical conditions within the interstellar medium of the Galaxy. I describe the PIXIE instrument and mission architecture needed to detect the inflationary signature using only 4 semiconductor bolometers.

  6. The use of statistical tools in field testing of putative effects of genetically modified plants on non-target organisms

    NARCIS (Netherlands)

    Semenov, Alexander V.; van Elsas, Jan Dirk; Glandorf, Debora C. M.; Schilthuizen, Menno; de Boer, Willem F.

    2013-01-01

    To fulfill existing guidelines, applicants that aim to place their genetically modified (GM) insect-resistant crop plants on the market are required to provide data from field experiments that address the potential impacts of the GM plants on nontarget organisms (NTO's). Such data may be based on va

  7. The use of statistical tools in field testing of putative effects of genetically modified plants on nontarget organisms

    NARCIS (Netherlands)

    Semenov, A.V.; Elsas, van J.D.; Glandorf, D.C.M.; Schilthuizen, M.; Boer, de W.F.

    2013-01-01

    To fulfill existing guidelines, applicants that aim to place their genetically modified (GM) insect-resistant crop plants on the market are required to provide data from field experiments that address the potential impacts of the GM plants on nontarget organisms (NTO's). Such data may be based on

  8. The use of statistical tools in field testing of putative effects of genetically modified plants on non-target organisms

    NARCIS (Netherlands)

    Semenov, Alexander V.; van Elsas, Jan Dirk; Glandorf, Debora C. M.; Schilthuizen, Menno; de Boer, Willem F.

    To fulfill existing guidelines, applicants that aim to place their genetically modified (GM) insect-resistant crop plants on the market are required to provide data from field experiments that address the potential impacts of the GM plants on nontarget organisms (NTO's). Such data may be based on

  9. Limits for primordial magnetic fields

    CERN Document Server

    Caprini, Chiara

    2011-01-01

    A possible explanation for the origin of the magnetic fields observed today in matter structures is that they were generated in the primordial universe. After briefly revising the model of a primordial stochastic magnetic field and sketching the main features of its time evolution in the primordial plasma, we illustrate the current upper bounds on the magnetic field amplitude and spectral index from Cosmic Microwave Background observations and gravitational wave production. We conclude that a primordial magnetic field generated by a non-causal process such as inflation with a red spectrum seems to be favoured as a seed for the magnetic fields observed today in structures.

  10. Growth of Primordial Black Holes

    Science.gov (United States)

    Harada, Tomohiro

    Primordial black holes have important observational implications through Hawking evaporation and gravitational radiation as well as being a candidate for cold dark matter. Those black holes are assumed to have formed in the early universe typically with the mass scale contained within the Hubble horizon at the formation epoch and subsequently accreted mass surrounding them. Numerical relativity simulation shows that primordial black holes of different masses do not accrete much, which contrasts with a simplistic Newtonian argument. We see that primordial black holes larger than the 'super-horizon' primordial black holes have decreasing energy and worm-hole like struture, suggesting the formation through quamtum processes.

  11. EBL-1, a putative erythrocyte binding protein of Plasmodium falciparum, maps within a favored linkage group in two genetic crosses.

    Science.gov (United States)

    Peterson, D S; Wellems, T E

    2000-01-05

    The Duffy binding-like (DBL) superfamily of Plasmodium falciparum encompasses genes which encode ligands for host cell receptors. This superfamily includes two distinct groups of genes, the var genes which encode antigenically variant cytoadherence proteins (PfEMP1), and the eba-175 gene which encodes a glycophorin A binding protein involved in erythrocyte invasion. Here we describe another DBL superfamily member related to eba-175, the ebl-1 gene. Like the eba-175 gene, ebl-1 is a single copy gene encoding DBL domains that have sequences and an overall arrangement distinct from var genes. The inheritance of ebl-1 was found to be strongly favored in two genetic crosses in which one parental clone lacked a chromosome segment carrying the gene. A proliferation phenotype has been previously linked to the same chromosome segment in the first genetic cross. These results suggest that ebl-1 and eba-175 are related members of a multigene family involved in the invasion of erythrocytes by P. falciparum.

  12. Primordial Black Holes

    CERN Document Server

    MacGibbon, Jane H; Linnemann, J T; Marinelli, S S; Stump, D; Tollefson, K

    2015-01-01

    Primordial Black Holes (PBHs) are of interest in many cosmological contexts. PBHs lighter than about 1012 kg are predicted to be directly detectable by their Hawking radiation. This radiation should produce both a diffuse extragalactic gamma-ray background from the cosmologically-averaged distribution of PBHs and gamma-ray burst signals from individual light black holes. The Fermi, Milagro, Veritas, HESS and HAWC observatories, in combination with new burst recognition methodologies, offer the greatest sensitivity for the detection of such black holes or placing limits on their existence.

  13. Analysis of the transcriptome of Erigeron breviscapus uncovers putative scutellarin and chlorogenic acids biosynthetic genes and genetic markers.

    Directory of Open Access Journals (Sweden)

    Ni-Hao Jiang

    Full Text Available Erigeron breviscapus (Vant. Hand-Mazz. is a famous medicinal plant. Scutellarin and chlorogenic acids are the primary active components in this herb. However, the mechanisms of biosynthesis and regulation for scutellarin and chlorogenic acids in E. breviscapus are considerably unknown. In addition, genomic information of this herb is also unavailable.Using Illumina sequencing on GAIIx platform, a total of 64,605,972 raw sequencing reads were generated and assembled into 73,092 non-redundant unigenes. Among them, 44,855 unigenes (61.37% were annotated in the public databases Nr, Swiss-Prot, KEGG, and COG. The transcripts encoding the known enzymes involved in flavonoids and in chlorogenic acids biosynthesis were discovered in the Illumina dataset. Three candidate cytochrome P450 genes were discovered which might encode flavone 6-hydroase converting apigenin to scutellarein. Furthermore, 4 unigenes encoding the homologues of maize P1 (R2R3-MYB transcription factors were defined, which might regulate the biosynthesis of scutellarin. Additionally, a total of 11,077 simple sequence repeat (SSR were identified from 9,255 unigenes. Of SSRs, tri-nucleotide motifs were the most abundant motif. Thirty-six primer pairs for SSRs were randomly selected for validation of the amplification and polymorphism. The result revealed that 34 (94.40% primer pairs were successfully amplified and 19 (52.78% primer pairs exhibited polymorphisms.Using next generation sequencing (NGS technology, this study firstly provides abundant genomic data for E. breviscapus. The candidate genes involved in the biosynthesis and transcriptional regulation of scutellarin and chlorogenic acids were obtained in this study. Additionally, a plenty of genetic makers were generated by identification of SSRs, which is a powerful tool for molecular breeding and genetics applications in this herb.

  14. Primordial polymer perturbations

    Energy Technology Data Exchange (ETDEWEB)

    Seahra, Sanjeev S.; Husain, Viqar [Department of Mathematics and Statistics, University of New Brunswick, Fredericton, NB, E3B 5A3 (Canada); Brown, Iain A. [Institute of Theoretical Astrophysics, University of Oslo, P.O. Box 1029 Blindern, N-0315 Oslo (Norway); Hossain, Golam Mortuza, E-mail: sseahra@unb.ca, E-mail: ibrown@astro.uio.no, E-mail: ghossain@iiserkol.ac.in, E-mail: vhusain@unb.ca [Department of Physical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur Campus, P.O. Krishi Viswavidyalaya, Nadia 741 252, WB (India)

    2012-10-01

    We study the generation of primordial fluctuations in pure de Sitter inflation where the quantum scalar field dynamics are governed by polymer (not Schroedinger) quantization. This quantization scheme is related to, but distinct from, the structures employed in Loop Quantum Gravity; and it modifies standard results above a polymer energy scale M{sub *}. We recover the scale invariant Harrison Zel'dovich spectrum for modes that have wavelengths bigger than M{sub *}{sup −1} at the start of inflation. The primordial spectrum for modes with initial wavelengths smaller than M{sub *}{sup −1} exhibits oscillations superimposed on the standard result. The amplitude of these oscillations is proportional to the ratio of the inflationary Hubble parameter H to the polymer energy scale. For reasonable choices of M{sub *}, we find that polymer effects are likely unobservable in CMB angular power spectra due to cosmic variance uncertainty, but future probes of baryon acoustic oscillations may be able to directly constrain the ratio H/M{sub *}.

  15. Origin of life. Primordial genetics: Information transfer in a pre-RNA world based on self-replicating beta-sheet amyloid conformers.

    Science.gov (United States)

    Maury, Carl Peter J

    2015-10-07

    The question of the origin of life on Earth can largely be reduced to the question of what was the first molecular replicator system that was able to replicate and evolve under the presumably very harsh conditions on the early Earth. It is unlikely that a functional RNA could have existed under such conditions and it is generally assumed that some other kind of information system preceded the RNA world. Here, I present an informational molecular system that is stable, self-replicative, environmentally responsive, and evolvable under conditions characterized by high temperatures, ultraviolet and cosmic radiation. This postulated pregenetic system is based on the amyloid fold, a functionally unique polypeptide fold characterized by a cross beta-sheet structure in which the beta strands are arranged perpendicular to the fiber axis. Beside an extraordinary structural robustness, the amyloid fold possesses a unique ability to transmit information by a three-dimensional templating mechanism. In amyloidogenesis short peptide monomers are added one by one to the growing end of the fiber. From the same monomeric subunits several structural variants of amyloid may be formed. Then, in a self-replicative mode, a specific amyloid conformer can act as a template and confer its spatially encoded information to daughter molecular entities in a repetitive way. In this process, the specific conformational information, the spatially changed organization, is transmitted; the coding element is the steric zipper structure, and recognition occurs by amino acid side chain complementarity. The amyloid information system fulfills several basic requirements of a primordial evolvable replicator system: (i) it is stable under the presumed primitive Earth conditions, (ii) the monomeric building blocks of the informational polymer can be formed from available prebiotic compounds, (iii) the system is self-assembling and self-replicative and (iv) it is adaptive to changes in the environment and

  16. Physics of primordial star formation

    Science.gov (United States)

    Yoshida, Naoki

    2012-09-01

    The study of primordial star formation has a history of nearly sixty years. It is generally thought that primordial stars are one of the key elements in a broad range of topics in astronomy and cosmology, from Galactic chemical evolution to the formation of super-massive blackholes. We review recent progress in the theory of primordial star formation. The standard theory of cosmic structure formation posits that the present-day rich structure of the Universe developed through gravitational amplification of tiny matter density fluctuations left over from the Big Bang. It has become possible to study primordial star formation rigorously within the framework of the standard cosmological model. We first lay out the key physical processes in a primordial gas. Then, we introduce recent developments in computer simulations. Finally, we discuss prospects for future observations of the first generation of stars.

  17. PRELIMINARY REPORT ON THE PUTATIVE ASSOCIATION OF IL10 -3575 T/A GENETIC POLYMORPHISM WITH MALARIA SYMPTOMS.

    Science.gov (United States)

    Domingues, Wilson; Kanunfre, Kelly Aparecida; Rodrigues, Jonatas Cristian; Teixeira, Leandro Emidio; Yamamoto, Lidia; Okay, Thelma Suely

    2016-01-01

    Only a small percentage of individuals living in endemic areas develop severe malaria suggesting that host genetic factors may play a key role. This study has determined the frequency of single nucleotide polymorphisms (SNPs) in some pro and anti-inflammatory cytokine gene sequences: IL6 (-174; rs1800795), IL12p40 (+1188; rs3212227), IL4 (+33; rs2070874), IL10 (-3575; rs1800890) and TGFb1 (+869; rs1800470), by means of PCR-RFLP. Blood samples were collected from 104 symptomatic and 37 asymptomatic subjects. Laboratory diagnosis was assessed by the thick blood smear test and nested-PCR. No association was found between IL6 (-174), IL12p40 (+1188), IL4 (+33), IL10 (- 3575), TGFb1 (+869) SNPs and malaria symptoms. However, regarding the IL10 -3575 T/A SNP, there were significantly more AA and AT subjects, carrying the polymorphic allele A, in the symptomatic group (c2 = 4.54, p = 0.01, OR = 0.40 [95% CI - 0.17- 0.94]). When the analysis was performed by allele, the frequency of the polymorphic allele A was also significantly higher in the symptomatic group (c2 = 4.50, p = 0.01, OR = 0.45 [95% CI - 0.21-0.95]). In conclusion, this study has suggested the possibility that the IL10 - 3575 T/A SNP might be associated with the presence and maintenance of malaria symptoms in individuals living in endemic areas. Taking into account that this polymorphism is related to decreased IL10 production, a possible role of this SNP in the pathophysiology of malaria is also suggested, but replication studies with a higher number of patients and evaluation of IL10 levels are needed for confirmation.

  18. The use of statistical tools in field testing of putative effects of genetically modified plants on nontarget organisms.

    Science.gov (United States)

    Semenov, Alexander V; Elsas, Jan Dirk; Glandorf, Debora C M; Schilthuizen, Menno; Boer, Willem F

    2013-08-01

    To fulfill existing guidelines, applicants that aim to place their genetically modified (GM) insect-resistant crop plants on the market are required to provide data from field experiments that address the potential impacts of the GM plants on nontarget organisms (NTO's). Such data may be based on varied experimental designs. The recent EFSA guidance document for environmental risk assessment (2010) does not provide clear and structured suggestions that address the statistics of field trials on effects on NTO's. This review examines existing practices in GM plant field testing such as the way of randomization, replication, and pseudoreplication. Emphasis is placed on the importance of design features used for the field trials in which effects on NTO's are assessed. The importance of statistical power and the positive and negative aspects of various statistical models are discussed. Equivalence and difference testing are compared, and the importance of checking the distribution of experimental data is stressed to decide on the selection of the proper statistical model. While for continuous data (e.g., pH and temperature) classical statistical approaches - for example, analysis of variance (ANOVA) - are appropriate, for discontinuous data (counts) only generalized linear models (GLM) are shown to be efficient. There is no golden rule as to which statistical test is the most appropriate for any experimental situation. In particular, in experiments in which block designs are used and covariates play a role GLMs should be used. Generic advice is offered that will help in both the setting up of field testing and the interpretation and data analysis of the data obtained in this testing. The combination of decision trees and a checklist for field trials, which are provided, will help in the interpretation of the statistical analyses of field trials and to assess whether such analyses were correctly applied. We offer generic advice to risk assessors and applicants that will

  19. Genetically based polymorphisms in morphology and life history associated with putative host races of the water lily leaf beetle, Galerucella nymphaeae.

    Science.gov (United States)

    Pappers, Stephanie M; van der Velde, Gerard; Ouborg, N Joop; van Groenendael, Jan M

    2002-08-01

    A host race is a population that is partially reproductively isolated from other conspecific populations as a direct consequence of adaptation to a specific host. The initial step in host race formation is the establishment of genetically based polymorphisms in, for example, morphology, preference, or performance. In this study we investigated whether polymorphisms observed in Galerucella nymphaeae have a genetic component. Galerucella nymphaeae, the water lily leaf beetle, is a herbivore which feeds and oviposits on the plant hosts Nuphar lutea and Nymphaea alba (both Nymphaeaceae) and Rumex hydrolapathum and Polygonum amphibium (both Polygonaceae). A full reciprocal crossing scheme (16 crosses, each replicated 10 times) and subsequent transplantation of 1,001 egg clutches revealed a genetic basis for differences in body length and mandibular width. The heritability value of these traits, based on midparent-offspring regression, ranged between 0.53 and 0.83 for the different diets. Offspring from Nymphaeaceae parents were on average 12% larger and had on average 18% larger mandibles than offspring from Polygonaceae parents. Furthermore, highly significant correlations were found between feeding preference of the offspring and the feeding preference of their parents. Finally, two fitness components were measured: development time and survival. Development time was influenced by diet, survival both by cross type and diet, the latter of which suggest adaptation of the beetles. This suggestion is strengthened by a highly significant cross x diet interaction effect for development time as well as for survival, which is generally believed to indicate local adaptation. Although no absolute genetic incompatibility among putative host races was observed, survival of the between-host family offspring, on each diet separately, was lower than the survival of the within-host family offspring on that particular host. Survival of offspring of two Nymphaeaceae parents was about

  20. Primordial Fluctuations within Teleparallelism

    CERN Document Server

    Wu, Yi-Peng

    2011-01-01

    To study the primordial fluctuations for gravity within teleparallelism, we perform a 3+1 decomposition of the vierbein field which makes the metric tensor identical to the ADM formulation. The torsion scalar is differ by a total divergence from the Ricci scalar under this representation as a consistent result. Using the unitary gauge of the scalar field, we obtain the same quadratic actions for both scalar and tensor perturbations as the standard ones in the minimal torsion scalar coupling. When the same scenario is applied to the higher-order action, $f(T)$ gravity, we find that the scalar-tensor coupling in the Einstein frame becomes a total divergence. Consequently, the cosmological perturbations are the same for $f(T)$ and $f(R)$ gravity theories in the earlier universe although the behaviors of the late time cosmic acceleration are apparently different.

  1. Characterization of a new Vaccinia virus isolate reveals the C23L gene as a putative genetic marker for autochthonous Group 1 Brazilian Vaccinia virus.

    Directory of Open Access Journals (Sweden)

    Felipe L Assis

    Full Text Available Since 1999, several Vaccinia virus (VACV isolates, the etiological agents of bovine vaccinia (BV, have been frequently isolated and characterized with various biological and molecular methods. The results from these approaches have grouped these VACV isolates into two different clusters. This dichotomy has elicited debates surrounding the origin of the Brazilian VACV and its epidemiological significance. To ascertain vital information to settle these debates, we and other research groups have made efforts to identify molecular markers to discriminate VACV from other viruses of the genus Orthopoxvirus (OPV and other VACV-BR groups. In this way, some genes have been identified as useful markers to discriminate between the VACV-BR groups. However, new markers are needed to infer ancestry and to correlate each sample or group with its unique epidemiological and biological features. The aims of this work were to characterize a new VACV isolate (VACV DMTV-2005 molecularly and biologically using conserved and non-conserved gene analyses for phylogenetic inference and to search for new genes that would elucidate the VACV-BR dichotomy. The VACV DMTV-2005 isolate reported in this study is biologically and phylogenetically clustered with other strains of Group 1 VACV-BR, the most prevalent VACV group that was isolated during the bovine vaccinia outbreaks in Brazil. Sequence analysis of C23L, the gene that encodes for the CC-chemokine-binding protein, revealed a ten-nucleotide deletion, which is a new Group 1 Brazilian VACV genetic marker. This deletion in the C23L open reading frame produces a premature stop-codon that is shared by all Group 1 VACV-BR strains and may also reflect the VACV-BR dichotomy; the deletion can also be considered to be a putative genetic marker for non-virulent Brazilian VACV isolates and may be used for the detection and molecular characterization of new isolates.

  2. Accretion, primordial black holes and standard cosmology

    Indian Academy of Sciences (India)

    B Nayak; P Singh

    2011-01-01

    Primordial black holes evaporate due to Hawking radiation. We find that the evaporation times of primordial black holes increase when accretion of radiation is included. Thus, depending on accretion efficiency, more primordial black holes are existing today, which strengthens the conjecture that the primordial black holes are the proper candidates for dark matter.

  3. Primordial germ cells and amnion development in the avian embryo

    NARCIS (Netherlands)

    De Melo Bernardo, Ana

    2016-01-01

    Primordial germ cells (PGCs) are the progenitors of the gametes, responsible for transmitting genetic information from generation to generation. Although there is a long history of gamete biology research, there is still a lot to be learned about many of the mechanisms underlying germ cell

  4. Mutations in the pericentrin (PCNT) gene cause primordial dwarfism.

    NARCIS (Netherlands)

    Rauch, A.; Thiel, C.T.; Schindler, D.; Wick, U.; Crow, Y.J.; Ekici, A.B.; Essen, A.J. van; Goecke, T.O.; Al-Gazali, L.; Chrzanowska, K.H.; Zweier, C.; Brunner, H.G.; Becker, K.; Curry, C.J.; Dallapiccola, B.; Devriendt, K.; Dorfler, A.; Kinning, E.; Megarbane, A.; Meinecke, P.; Semple, R.K.; Spranger, S.; Toutain, A.; Trembath, R.C.; Voss, E.; Wilson, L.; Hennekam, R.C.M.; Zegher, F. de; Dorr, H.G.; Reis, A.

    2008-01-01

    Fundamental processes influencing human growth can be revealed by studying extreme short stature. Using genetic linkage analysis, we find that biallelic loss-of-function mutations in the centrosomal pericentrin (PCNT) gene on chromosome 21q22.3 cause microcephalic osteodysplastic primordial dwarfism

  5. Mutations in the pericentrin (PCNT) gene cause primordial dwarfism

    NARCIS (Netherlands)

    Rauch, Anita; Thiel, Christian T.; Schindler, Detlev; Wick, Ursula; Crow, Yanick J.; Ekici, Arif B.; van Essen, Anthonie J.; Goecke, Timm O.; Al-Gazali, Lihadh; Chrzanowska, Krystyna H.; Zweier, Christiane; Brunner, Han G.; Becker, Kristin; Curry, Cynthia J.; Dallapiccola, Bruno; Devriendt, Koenraad; Doerfler, Arnd; Kinning, Esther; Megarbane, Andre; Meinecke, Peter; Semple, Robert K.; Spranger, Stephanie; Toutain, Annick; Trembath, Richard C.; Voss, Egbert; Wilson, Louise; Hennekam, Raoul; de Zegher, Francis; Doerr, Helmuth-Guenther; Reis, Andre

    2008-01-01

    Fundamental processes influencing human growth can be revealed by studying extreme short stature. Using genetic linkage analysis, we find that biallelic loss- of- function mutations in the centrosomal pericentrin ( PCNT) gene on chromosome 21q22.3 cause microcephalic osteodysplastic primordial

  6. Primordial germ cells and amnion development in the avian embryo

    NARCIS (Netherlands)

    De Melo Bernardo, Ana

    2016-01-01

    Primordial germ cells (PGCs) are the progenitors of the gametes, responsible for transmitting genetic information from generation to generation. Although there is a long history of gamete biology research, there is still a lot to be learned about many of the mechanisms underlying germ cell developme

  7. Primordial features and Planck polarization

    Science.gov (United States)

    Hazra, Dhiraj Kumar; Shafieloo, Arman; Smoot, George F.; Starobinsky, Alexei A.

    2016-09-01

    With the Planck 2015 Cosmic Microwave Background (CMB) temperature and polarization data, we search for possible features in the primordial power spectrum (PPS). We revisit the Wiggly Whipped Inflation (WWI) framework and demonstrate how generation of some particular primordial features can improve the fit to Planck data. WWI potential allows the scalar field to transit from a steeper potential to a nearly flat potential through a discontinuity either in potential or in its derivatives. WWI offers the inflaton potential parametrizations that generate a wide variety of features in the primordial power spectra incorporating most of the localized and non-local inflationary features that are obtained upon reconstruction from temperature and polarization angular power spectrum. At the same time, in a single framework it allows us to have a background parameter estimation with a nearly free-form primordial spectrum. Using Planck 2015 data, we constrain the primordial features in the context of Wiggly Whipped Inflation and present the features that are supported both by temperature and polarization. WWI model provides more than 13 improvement in χ2 fit to the data with respect to the best fit power law model considering combined temperature and polarization data from Planck and B-mode polarization data from BICEP and Planck dust map. We use 2-4 extra parameters in the WWI model compared to the featureless strict slow roll inflaton potential. We find that the differences between the temperature and polarization data in constraining background cosmological parameters such as baryon density, cold dark matter density are reduced to a good extent if we use primordial power spectra from WWI. We also discuss the extent of bispectra obtained from the best potentials in arbitrary triangular configurations using the BI-spectra and Non-Gaussianity Operator (BINGO).

  8. Primordial Magnetic Fields and Causality

    CERN Document Server

    Durrer, R; Durrer, Ruth; Caprini, Chiara

    2003-01-01

    In this letter we discuss the implications of causality on a primordial magnetic field. We show that the residual field on large scales is much stronger suppressed than usually assumed and that a helical component is even suppressed even more than the parity even part. We show that due to this strong suppression, even maximal primordial fields generated at the electroweak phase transition can just marginally seed the fields in galaxies and clusters, but they cannot leave any detectable imprint on the cosmic microwave background.

  9. Primordial magnetism in CMB polarization

    Science.gov (United States)

    Pogosian, Levon

    2014-03-01

    A large scale B-mode signal in the CMB polarization would constitute a smoking gun of Inflation and is the main target of several ongoing and upcoming experiments. In this contribution, I consider distinguishing features of another potential source of primordial B-modes - magnetic fields. In particular, the Faraday Rotation of CMB polarization provides a distinctive signature of cosmic magnetic fields through the characteristic frequency dependence and the mode-coupling correlations of the CMB variables. I discuss constraints on primordial magnetism that can be expected from future CMB experiments, taking into account the obstruction caused by the magnetic field of the Milky Way.

  10. Spin distribution of primordial black holes

    Science.gov (United States)

    Chiba, Takeshi; Yokoyama, Shuichiro

    2017-08-01

    We estimate the spin distribution of primordial black holes based on the recent study of the critical phenomena in the gravitational collapse of a rotating radiation fluid. We find that primordial black holes are mostly slowly rotating.

  11. Issues concerning loop corrections to the primordial power spectra

    Energy Technology Data Exchange (ETDEWEB)

    Miao, S.P. [Institute for Theoretical Physics and Spinoza Institute, Utrecht University, Leuvenlaan 4, Postbus 80.195, 3508 TD Utrecht (Netherlands); Woodard, R.P., E-mail: S.Miao@uu.nl, E-mail: woodard@phys.ufl.edu [Department of Physics, University of Florida, Gainesville, FL 32611 (United States)

    2012-07-01

    We expound ten principles in an attempt to clarify the debate over infrared loop corrections to the primordial scalar and tensor power spectra from inflation. Among other things we note that existing proposals for nonlinear extensions of the scalar fluctuation field ζ introduce new ultraviolet divergences which no one understands how to renormalize. Loop corrections and higher correlators of these putative observables would also be enhanced by inverse powers of the slow roll parameter ε. We propose an extension which should be better behaved.

  12. Oscillations in the primordial bispectrum

    NARCIS (Netherlands)

    Meerburg, P.D.

    2010-01-01

    There exist several models of inflation that produce primordial bispectra that contain a large number of oscillations. In this paper we discuss these models, and aim at finding a method of detecting such bispectra in the data. We explain how the recently proposed method of mode expansion of

  13. Primordial fluctuations from nonlinear couplings

    CERN Document Server

    Calzetta, E A; Calzetta, Esteban A.; Gonorazky, Sonia

    1997-01-01

    We study the spectrum of primordial fluctuations in theories where the inflaton field is coupled to massless fields and/or to itself. Conformally invariant theories generically predict a scale invariant spectrum. Scales entering the theory through infrared divergences cause logarithmic corrections to the spectrum, tiltilng it towards the blue. We discuss in some detail wether these fluctuations are quantum or classical in nature.

  14. Identification and genetic mapping of the putative Thinopyrum intermedium-derived dominant powdery mildew resistance gene PmL962 on wheat chromosome arm 2BS

    Science.gov (United States)

    Powdery mildew, caused by Blumeria graminis f. sp. tritici (Bgt), is a destructive disease affecting the production of wheat (Triticum aestivum). Powdery mildew resistance was putatively transferred from Thinopyrum intermedium to the common wheat line L962, which conferred resistance to multiple Ch...

  15. Searching for Primordial Antimatter

    Science.gov (United States)

    2008-10-01

    Scientists are on the hunt for evidence of antimatter - matter's arch nemesis - leftover from the very early Universe. New results using data from NASA's Chandra X-ray Observatory and Compton Gamma Ray Observatory suggest the search may have just become even more difficult. Antimatter is made up of elementary particles, each of which has the same mass as their corresponding matter counterparts --protons, neutrons and electrons -- but the opposite charges and magnetic properties. When matter and antimatter particles collide, they annihilate each other and produce energy according to Einstein's famous equation, E=mc2. According to the Big Bang model, the Universe was awash in particles of both matter and antimatter shortly after the Big Bang. Most of this material annihilated, but because there was slightly more matter than antimatter - less than one part per billion - only matter was left behind, at least in the local Universe. Trace amounts of antimatter are believed to be produced by powerful phenomena such as relativistic jets powered by black holes and pulsars, but no evidence has yet been found for antimatter remaining from the infant Universe. How could any primordial antimatter have survived? Just after the Big Bang there was believed to be an extraordinary period, called inflation, when the Universe expanded exponentially in just a fraction of a second. "If clumps of matter and antimatter existed next to each other before inflation, they may now be separated by more than the scale of the observable Universe, so we would never see them meet," said Gary Steigman of The Ohio State University, who conducted the study. "But, they might be separated on smaller scales, such as those of superclusters or clusters, which is a much more interesting possibility." X-rayChandra X-ray Image In that case, collisions between two galaxy clusters, the largest gravitationally-bound structures in the Universe, might show evidence for antimatter. X-ray emission shows how much hot

  16. Microcephalic osteodysplastic primordial dwarfism type 1.

    Science.gov (United States)

    Ferrell, Steven; Johnson, Aaron; Pearson, Waylon

    2016-06-16

    Microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1) is an uncommon cause of microcephaly and intrauterine growth retardation in a newborn. Early identifying features include but are not limited to sloping forehead, micrognathia, sparse hair, including of eyebrows and short limbs. Immediate radiological findings may include partial or complete agenesis of the corpus callosum, interhemispheric cyst and shallow acetabula leading to dislocation. Genetic testing displaying a mutation in RNU4ATAC gene is necessary for definitive diagnosis. Early identification is important as MOPD1 is an autosomal recessive condition and could present in subsequent pregnancies. The purpose of this case is to both identify and describe some common physical findings related to MOPD1. We present a case of MOPD1 in a girl born to non-consanguineous parents that was distinct for subglottic stenosis and laryngeal cleft. 2016 BMJ Publishing Group Ltd.

  17. Cosmological Cosmic Rays: Sharpening the Primordial Lithium Problem

    CERN Document Server

    Prodanovic, Tijana

    2007-01-01

    Cosmic structure formation leads to large-scale shocked baryonic flows which are expected to produce a cosmological population of structure-formation cosmic rays (SFCRs). Interactions between SFCRs and ambient baryons will produce lithium isotopes via \\alpha+\\alpha \\to ^{6,7}Li. This pre-Galactic (but non-primordial) lithium should contribute to the primordial 7Li measured in halo stars and must be subtracted in order to arrive to the true observed primordial lithium abundance. In this paper we point out that the recent halo star 6Li measurements can be used to place a strong constraint to the level of such contamination, because the exclusive astrophysical production of 6Li is from cosmic-ray interactions. We find that the putative 6Li plateau, if due to pre-Galactic cosmic-ray interactions, implies that SFCR-produced lithium represents Li_{SFCR}/Li_{plateau}\\approx 15% of the observed elemental Li plateau. Taking the remaining plateau Li to be cosmological 7Li, we find a revised (and slightly worsened) disc...

  18. Scientific Realism and Primordial Cosmology

    CERN Document Server

    Azhar, Feraz

    2016-01-01

    We discuss scientific realism from the perspective of modern cosmology, especially primordial cosmology: i.e. the cosmological investigation of the very early universe. We first (Section 2) state our allegiance to scientific realism, and discuss what insights about it cosmology might yield, as against "just" supplying scientific claims that philosophers can then evaluate. In particular, we discuss: the idea of laws of cosmology, and limitations on ascertaining the global structure of spacetime. Then we review some of what is now known about the early universe (Section 3): meaning, roughly, from a thousandth of a second after the Big Bang onwards(!). The rest of the paper takes up two issues about primordial cosmology, i.e. the very early universe, where "very early" means, roughly, much earlier (logarithmically) than one second after the Big Bang: say, less than $10^{-11}$ seconds. Both issues illustrate that familiar philosophical threat to scientific realism, the under-determination of theory by data---on a...

  19. Non-adiabatic primordial fluctuations

    Energy Technology Data Exchange (ETDEWEB)

    Noller, Johannes; Magueijo, Joao, E-mail: johannes.noller08@imperial.ac.uk [Theoretical Physics Group, Imperial College, London SW7 2BZ (United Kingdom)

    2011-05-21

    We consider general mixtures of isocurvature and adiabatic cosmological perturbations. With a minimal assumption set consisting of the linearized Einstein equations and a primordial perfect fluid we derive the second-order action and its curvature variables. We also allow for varying equation of state and speed of sound profiles. The derivation is therefore carried out at the same level of generality that has been achieved for adiabatic modes before. As a result we find a new conserved super-horizon quantity and relate it to the adiabatically conserved curvature perturbation. Finally we demonstrate how the formalism can be applied by considering a Chaplygin gas-like primordial matter model, finding two scale-invariant solutions for structure formation.

  20. Primordial density and BAO reconstruction

    CERN Document Server

    Zhu, Hong-Ming; Chen, Xuelei

    2016-01-01

    We present a new method to reconstruct the primordial (linear) density field using the estimated nonlinear displacement field. The divergence of the displacement field gives the reconstructed density field. We solve the nonlinear displacement field in the 1D cosmology and show the reconstruction results. The new reconstruction algorithm recovers a lot of linear modes and reduces the nonlinear damping scale significantly. The successful 1D reconstruction results imply the new algorithm should also be a promising technique in the 3D case.

  1. Primordial power spectrum from Planck

    CERN Document Server

    Hazra, Dhiraj Kumar; Souradeep, Tarun

    2014-01-01

    Using modified Richardson-Lucy algorithm we reconstruct the primordial power spectrum (PPS) from Planck Cosmic Microwave Background (CMB) temperature anisotropy data. In our analysis we use different combinations of angular power spectra from Planck to reconstruct the shape of the primordial power spectrum and locate possible features. Performing an extensive error analysis we found the dip near $\\ell\\sim750-850$ represents the most prominent feature in the data. Feature near $\\ell\\sim1800-2000$ is detectable with high confidence only in 217 GHz spectrum and is apparently consequence of a small systematic as described in the revised Planck 2013 papers. Fixing the background cosmological parameters and the foreground nuisance parameters to their best fit baseline values, we report that the best fit power law primordial power spectrum is consistent with the reconstructed form of the PPS at 2$\\sigma$ C.L. of the estimated errors (apart from the local features mentioned above). As a consistency test, we found the...

  2. Primordial features and Planck polarization

    CERN Document Server

    Hazra, Dhiraj Kumar; Smoot, George F; Starobinsky, Alexei A

    2016-01-01

    With the Planck 2015 Cosmic Microwave Background (CMB) temperature and polarization data, we examine possibility of having features in the primordial power spectrum (PPS). We revisit the Wiggly Whipped Inflation (WWI) framework and demonstrate how generation of some particular primordial features can improve the fit to Planck data. WWI potential allows the scalar field to transit from a steeper potential to a nearly flat potential through a discontinuity either in potential or in its derivatives. Using Planck 2015 data, we constrain the primordial features in the context of Wiggly Whipped Inflation and present the features that are supported both by temperature and polarization. WWI model provides upto $\\sim12-14$ improvement in $\\chi^2$ fit to the data with respect to the best fit power law model considering combined temperature and polarization data from Planck and B-mode polarization data from BICEP and Planck dust map. We use 2-4 extra parameters in the WWI model compared to the featureless strict slow ro...

  3. Long-term culture of chicken primordial germ cells isolated from embryonic blood and production of germline chimaeric chickens.

    Science.gov (United States)

    Naito, Mitsuru; Harumi, Takashi; Kuwana, Takashi

    2015-02-01

    Production of germline chimaeric chickens by the transfer of cultured primordial germ cells (PGC) is a useful system for germline manipulation. A novel culture system was developed for chicken PGC isolated from embryonic blood. The isolated PGC were cultured on feeder cells derived from chicken embryonic fibroblast. The cultured PGC formed colonies and they proliferated about 300-times during the first 30 days. The cultured PGC retained the ability to migrate to recipient gonads and were also chicken VASA homologue (CVH)-positive. Female PGC were present in the mixed-sex PGC populations cultured for more than 90 days and gave rise to viable offspring efficiently via germline chimaeric chickens. Male cultured PGC were transferred to recipient embryos and produced putative chimaeric chickens. The DNA derived from the cultured PGC was detected in the sperm samples of male putative chimaeric chickens, but no donor derived offspring were obtained. Donor-derived offspring were also obtained from germline chimaeric chickens by the transfer of frozen-thawed cultured PGC. The culture method for PGC developed in the present study is useful for manipulation of the germline in chickens, such as preservation of genetic resources and gene transfer.

  4. Cellular and molecular regulation of the activation of mammalian primordial follicles: somatic cells initiate follicle activation in adulthood.

    Science.gov (United States)

    Zhang, Hua; Liu, Kui

    2015-01-01

    The first small follicles to appear in the mammalian ovaries are primordial follicles. The initial pool of primordial follicles serves as the source of developing follicles and oocytes for the entire reproductive lifespan of the animal. Although the selective activation of primordial follicles is critical for female fertility, its underlying mechanisms have remained poorly understood. A search of PubMed was conducted to identify peer-reviewed literature pertinent to the study of mammalian primordial follicle activation, especially recent reports of the role of primordial follicle granulosa cells (pfGCs) in regulating this process. In recent years, molecular mechanisms that regulate the activation of primordial follicles have been elucidated, mostly through the use of genetically modified mouse models. Several molecules and pathways operating in both the somatic pfGCs and oocytes, such as the phosphatidylinositol 3 kinase (PI3K) and the mechanistic target of rapamycin complex 1 (mTORC1) pathways, have been shown to be important for primordial follicle activation. More importantly, recent studies have provided an updated view of how exactly signaling pathways in pfGCs and in oocytes, such as the KIT ligand (KL) and KIT, coordinate in adult ovaries so that the activation of primordial follicles is achieved. In this review, we have provided an updated picture of how mammalian primordial follicles are activated. The functional roles of pfGCs in governing the activation of primordial follicles in adulthood are highlighted. The in-depth understanding of the cellular and molecular mechanisms of primordial follicle activation will hopefully lead to more treatments of female infertility, and the current progress indicates that the use of existing primordial follicles as a source for obtaining fertilizable oocytes as a new treatment for female infertility is just around the corner. © The Author 2015. Published by Oxford University Press on behalf of the European Society of

  5. A genetic link between epigenetic repressor AS1-AS2 and a putative small subunit processome in leaf polarity establishment of Arabidopsis

    Directory of Open Access Journals (Sweden)

    Yoko Matsumura

    2016-07-01

    Full Text Available Although the DEAD-box RNA helicase family is ubiquitous in eukaryotes, its developmental role remains unelucidated. Here, we report that cooperative action between the Arabidopsis nucleolar protein RH10, an ortholog of human DEAD-box RNA helicase DDX47, and the epigenetic repressor complex of ASYMMETRIC-LEAVES1 (AS1 and AS2 (AS1-AS2 is critical to repress abaxial (ventral genes ETT/ARF3 and ARF4, which leads to adaxial (dorsal development in leaf primordia at shoot apices. Double mutations of rh10-1 and as2 (or as1 synergistically up-regulated the abaxial genes, which generated abaxialized filamentous leaves with loss of the adaxial domain. DDX47 is part of the small subunit processome (SSUP that mediates rRNA biogenesis. In rh10-1 we found various defects in SSUP-related events, such as: accumulation of 35S/33S rRNA precursors; reduction in the 18S/25S ratio; and nucleolar hypertrophy. Double mutants of as2 with mutations of genes that encode other candidate SSUP-related components such as nucleolin and putative rRNA methyltransferase exhibited similar synergistic defects caused by up-regulation of ETT/ARF3 and ARF4. These results suggest a tight link between putative SSUP and AS1-AS2 in repression of the abaxial-determining genes for cell fate decisions for adaxial development.

  6. A genetic link between epigenetic repressor AS1-AS2 and a putative small subunit processome in leaf polarity establishment of Arabidopsis

    Science.gov (United States)

    Matsumura, Yoko; Ohbayashi, Iwai; Takahashi, Hiro; Kojima, Shoko; Ishibashi, Nanako; Keta, Sumie; Nakagawa, Ayami; Hayashi, Rika; Saéz-Vásquez, Julio; Echeverria, Manuel; Sugiyama, Munetaka; Nakamura, Kenzo; Machida, Chiyoko

    2016-01-01

    ABSTRACT Although the DEAD-box RNA helicase family is ubiquitous in eukaryotes, its developmental role remains unelucidated. Here, we report that cooperative action between the Arabidopsis nucleolar protein RH10, an ortholog of human DEAD-box RNA helicase DDX47, and the epigenetic repressor complex of ASYMMETRIC-LEAVES1 (AS1) and AS2 (AS1-AS2) is critical to repress abaxial (ventral) genes ETT/ARF3 and ARF4, which leads to adaxial (dorsal) development in leaf primordia at shoot apices. Double mutations of rh10-1 and as2 (or as1) synergistically up-regulated the abaxial genes, which generated abaxialized filamentous leaves with loss of the adaxial domain. DDX47 is part of the small subunit processome (SSUP) that mediates rRNA biogenesis. In rh10-1 we found various defects in SSUP-related events, such as: accumulation of 35S/33S rRNA precursors; reduction in the 18S/25S ratio; and nucleolar hypertrophy. Double mutants of as2 with mutations of genes that encode other candidate SSUP-related components such as nucleolin and putative rRNA methyltransferase exhibited similar synergistic defects caused by up-regulation of ETT/ARF3 and ARF4. These results suggest a tight link between putative SSUP and AS1-AS2 in repression of the abaxial-determining genes for cell fate decisions for adaxial development. PMID:27334696

  7. [Human Primordial Germ Cell Specification--Breakthrough In Culture and Hopes for Therapeutic Utilization].

    Science.gov (United States)

    Magnúsdóttir, Erna

    2015-10-01

    Germ cells are the precursors to the gametes that carry genetic and epigenetic information between human generations and generate a new individual. Because germ cells are specified early during embryogenesis, at the time of embryo implantation, they are inaccessible for research. Our understanding of their biology has therefore developed slowly since their identification over one hundred years ago. As a result of research into the properties of human and mouse embryonic stem cells and primordial germ cells, scientists have now succeeded in efficiently generating human primordial germ cells in culture by embryonic stem cell and induced pluripotent stem cell culture. In this review we will discuss the state of our knowledge of human primordial germ cells and how research into the pluripotent properties of human and mouse embryonic germ cells has led to this breakthrough. In addition we will discuss the possible utilization of a cell culture system of human primordial germ cells for research into and treatment of germ cell related abnormalities.

  8. "Ocular moyamoya" syndrome in a patient with features of microcephalic osteodysplastic primordial dwarfism type II.

    Science.gov (United States)

    Bang, Genie M; Kirmani, Salman; Patton, Alice; Pulido, Jose S; Brodsky, Michael C

    2013-02-01

    Primordial dwarfism refers to severely impaired growth beginning early in fetal life. There are many genetic causes of primordial dwarfism, including disorders classified as microcephalic osteodysplastic primordial dwarfism. Microcephalic osteodysplastic primordial dwarfism type II is an autosomal-recessive disease characterized by small stature, bone and dental anomalies, and characteristic facies. Affected patients have a high risk of stroke secondary to progressive cerebral vascular anomalies, which often are classified as moyamoya disease. We present the case of a boy with features suggestive of MOPD II with unilateral moyamoya cerebrovascular changes and correlative moyamoya collaterals involving the iris of the ipsilateral eye. Copyright © 2013 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved.

  9. RTTN Mutations Cause Primary Microcephaly and Primordial Dwarfism in Humans.

    Science.gov (United States)

    Shamseldin, Hanan; Alazami, Anas M; Manning, Melanie; Hashem, Amal; Caluseiu, Oana; Tabarki, Brahim; Esplin, Edward; Schelley, Susan; Innes, A Micheil; Parboosingh, Jillian S; Lamont, Ryan; Majewski, Jacek; Bernier, Francois P; Alkuraya, Fowzan S

    2015-12-03

    Primary microcephaly is a developmental brain anomaly that results from defective proliferation of neuroprogenitors in the germinal periventricular zone. More than a dozen genes are known to be mutated in autosomal-recessive primary microcephaly in isolation or in association with a more generalized growth deficiency (microcephalic primordial dwarfism), but the genetic heterogeneity is probably more extensive. In a research protocol involving autozygome mapping and exome sequencing, we recruited a multiplex consanguineous family who is affected by severe microcephalic primordial dwarfism and tested negative on clinical exome sequencing. Two candidate autozygous intervals were identified, and the second round of exome sequencing revealed a single intronic variant therein (c.2885+8A>G [p.Ser963(∗)] in RTTN exon 23). RT-PCR confirmed that this change creates a cryptic splice donor and thus causes retention of the intervening 7 bp of the intron and leads to premature truncation. On the basis of this finding, we reanalyzed the exome file of a second consanguineous family affected by a similar phenotype and identified another homozygous change in RTTN as the likely causal mutation. Combined linkage analysis of the two families confirmed that RTTN maps to the only significant linkage peak. Finally, through international collaboration, a Canadian multiplex family affected by microcephalic primordial dwarfism and biallelic mutation of RTTN was identified. Our results expand the phenotype of RTTN-related disorders, hitherto limited to polymicrogyria, to include microcephalic primordial dwarfism with a complex brain phenotype involving simplified gyration. Copyright © 2015 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  10. Genetic mapping reveals that sinefungin resistance in Toxoplasma gondii is controlled by a putative amino acid transporter locus that can be used as a negative selectable marker.

    Science.gov (United States)

    Behnke, Michael S; Khan, Asis; Sibley, L David

    2015-02-01

    Quantitative trait locus (QTL) mapping studies have been integral in identifying and understanding virulence mechanisms in the parasite Toxoplasma gondii. In this study, we interrogated a different phenotype by mapping sinefungin (SNF) resistance in the genetic cross between type 2 ME49-FUDR(r) and type 10 VAND-SNF(r). The genetic map of this cross was generated by whole-genome sequencing of the progeny and subsequent identification of single nucleotide polymorphisms (SNPs) inherited from the parents. Based on this high-density genetic map, we were able to pinpoint the sinefungin resistance phenotype to one significant locus on chromosome IX. Within this locus, a single nonsynonymous SNP (nsSNP) resulting in an early stop codon in the TGVAND_290860 gene was identified, occurring only in the sinefungin-resistant progeny. Using CRISPR/CAS9, we were able to confirm that targeted disruption of TGVAND_290860 renders parasites sinefungin resistant. Because disruption of the SNR1 gene confers resistance, we also show that it can be used as a negative selectable marker to insert either a positive drug selection cassette or a heterologous reporter. These data demonstrate the power of combining classical genetic mapping, whole-genome sequencing, and CRISPR-mediated gene disruption for combined forward and reverse genetic strategies in T. gondii.

  11. The Primordial Inflation Explorer (PIXIE)

    Science.gov (United States)

    Kogut, Alan; Chuss, David T.; Dotson, Jessie; Dwek, Eli; Fixsen, Dale J.; Halpern, Mark; Hinshaw, Gary F.; Meyer, Stephan; Moseley, S. Harvey; Seiffert, Michael D.; hide

    2014-01-01

    The Primordial Inflation Explorer is an Explorer-class mission to measure the gravity-wave signature of primordial inflation through its distinctive imprint on the linear polarization of the cosmic microwave background. PIXIE uses an innovative optical design to achieve background-limited sensitivity in 400 spectral channels spanning 2.5 decades in frequency from 30 GHz to 6 THz (1 cm to 50 micron wavelength). Multi-moded non-imaging optics feed a polarizing Fourier Transform Spectrometer to produce a set of interference fringes, proportional to the difference spectrum between orthogonal linear polarizations from the two input beams. Multiple levels of symmetry and signal modulation combine to reduce the instrumental signature and confusion from unpolarized sources to negligible levels. PIXIE will map the full sky in Stokes I, Q, and U parameters with angular resolution 2.6 deg and sensitivity 0.2 µK per 1 deg square pixel. The principal science goal is the detection and characterization of linear polarization from an inflationary epoch in the early universe, with tensor-to-scalar ratio r less than 10(exp -3) at 5 standard deviations. In addition, PIXIE will measure the absolute frequency spectrum to constrain physical processes ranging from inflation to the nature of the first stars to the physical conditions within the interstellar medium of the Galaxy. We describe the PIXIE instrument and mission architecture with an emphasis on the expected level of systematic error suppression.

  12. The Primordial Inflation Explorer (PIXIE)

    Science.gov (United States)

    Kogut, Alan; Chluba, Jens; Fixsen, Dale J.; Meyer, Stephan; Spergel, David

    2016-07-01

    The Primordial Inflation Explorer is an Explorer-class mission to open new windows on the early universe through measurements of the polarization and absolute frequency spectrum of the cosmic microwave background. PIXIE will measure the gravitational-wave signature of primordial inflation through its distinctive imprint in linear polarization, and characterize the thermal history of the universe through precision measurements of distortions in the blackbody spectrum. PIXIE uses an innovative optical design to achieve background-limited sensitivity in 400 spectral channels spanning over 7 octaves in frequency from 30 GHz to 6 THz (1 cm to 50 micron wavelength). Multi-moded non-imaging optics feed a polarizing Fourier Transform Spectrometer to produce a set of interference fringes, proportional to the difference spectrum between orthogonal linear polarizations from the two input beams. Multiple levels of symmetry and signal modulation combine to reduce systematic errors to negligible levels. PIXIE will map the full sky in Stokes I, Q, and U parameters with angular resolution 2.6° and sensitivity 70 nK per 1° square pixel. The principal science goal is the detection and characterization of linear polarization from an inflationary epoch in the early universe, with tensor-to-scalar ratio r architecture required to measure the CMB to the limits imposed by astrophysical foregrounds.

  13. Oscillations in the primordial bispectrum: Mode expansion

    NARCIS (Netherlands)

    Meerburg, P.D.

    2010-01-01

    We consider the presence of oscillations in the primordial bispectrum, inspired by three different cosmological models; features in the primordial potential, resonant type non-Gaussianities, and deviation from the standard Bunch-Davies vacuum. In order to put constraints on their bispectra, a logica

  14. Primordial Non-Gaussianity and Reionization

    CERN Document Server

    Lidz, Adam; Adshead, Peter; Dodelson, Scott

    2013-01-01

    The statistical properties of the primordial perturbations contain clues about the origins of those fluctuations. Although the Planck collaboration has recently obtained tight constraints on primordial non-gaussianity from cosmic microwave background measurements, it is still worthwhile to mine upcoming data sets in effort to place independent or competitive limits. The ionized bubbles that formed at redshift z~6-20 during the Epoch of Reionization are seeded by primordial overdensities, and so the statistics of the ionization field at high redshift are related to the statistics of the primordial field. Here we model the effect of primordial non-gaussianity on the reionization field. The epoch and duration of reionization are affected as are the sizes of the ionized bubbles, but these changes are degenerate with variations in the properties of the ionizing sources and the surrounding intergalactic medium. A more promising signature is the power spectrum of the spatial fluctuations in the ionization field, whi...

  15. Bell Violation in Primordial Cosmology

    Directory of Open Access Journals (Sweden)

    Sayantan Choudhury

    2017-02-01

    Full Text Available In this paper, we have worked on the possibility of setting up an Bell’s inequality violating experiment in the context of primordial cosmology following the fundamental principles of quantum mechanics. To set up this proposal, we have introduced a model-independent theoretical framework using which we have studied the creation of new massive particles for the scalar fluctuations in the presence of an additional time-dependent mass parameter. Next we explicitly computed the one-point and two-point correlation functions from this setup. Then, we comment on the measurement techniques of isospin breaking interactions of newly introduced massive particles and its further prospects. After that, we give an example of the string theory-originated axion monodromy model in this context. Finally, we provide a bound on the heavy particle mass parameter for any arbitrary spin field.

  16. Primordial Magnetic Fields that Last?

    CERN Document Server

    Carroll, S M; Carroll, Sean M.; Field, George B.

    1998-01-01

    The magnetic fields we observe in galaxies today may have their origins in the very early universe. While a number of mechanisms have been proposed which lead to an appreciable field amplitude at early times, the subsequent evolution of the field is of crucial importance, especially whether the correlation length of the field can grow as large as the size of a protogalaxy. This talk is a report on work in progress, in which we consider the fate of one specific primordial field scenario, driven by pseudoscalar effects near the electroweak phase transition. We argue that such a scenario has a number of attractive features, although it is still uncertain whether a field of appropriate size can survive until late times.

  17. Primordial Germ Cell Specification and Migration.

    Science.gov (United States)

    Marlow, Florence

    2015-01-01

    Primordial germ cells are the progenitor cells that give rise to the gametes. In some animals, the germline is induced by zygotic transcription factors, whereas in others, primordial germ cell specification occurs via inheritance of maternally provided gene products known as germ plasm. Once specified, the primordial germ cells of some animals must acquire motility and migrate to the gonad in order to survive. In all animals examined, perinuclear structures called germ granules form within germ cells. This review focuses on some of the recent studies, conducted by several groups using diverse systems, from invertebrates to vertebrates, which have provided mechanistic insight into the molecular regulation of germ cell specification and migration.

  18. The Solar System primordial lead

    Science.gov (United States)

    Blichert-Toft, Janne; Zanda, Brigitte; Ebel, Denton S.; Albarède, Francis

    2010-11-01

    Knowledge of the primordial isotope composition of Pb in the Solar System is critical to the understanding of the early evolution of Earth and other planetary bodies. Here we present new Pb isotopic data on troilite (FeS) nodules from a number of different iron meteorites: Canyon Diablo, Mundrabilla, Nantan, Seeläsgen, Toluca (IAB-IIICD), Cape York (IIIA), Mt Edith (IIIB), and Seymchan (pallasite). Lead abundances and isotopic compositions typically vary from one troilite inclusion to another, even within the same meteorite. The most primitive Pb was found in three leach fractions of two exceptionally Pb-rich Nantan troilite nodules. Its 204Pb/ 206Pb is identical to that of Canyon Diablo troilite as measured by Tatsumoto et al. [M. Tatsumoto, R.J. Knight, C.J. Allègre, Time differences in the formation of meteorites as determined from the ratio of lead-207 to lead-206, Science 180(1973) 1279-1283]. However, our measurements of 207Pb/ 206Pb and 208Pb/ 206Pb are significantly higher than theirs, as well as other older literature data obtained by TIMS, while consistent with the recent data of Connelly et al. [J.N. Connelly, M. Bizzarro, K. Thrane, J.A. Baker, The Pb-Pb age of Angrite SAH99555 revisited, Geochim. Cosmochim. Acta 72(2008) 4813-4824], a result we ascribe to instrumental mass fractionation having biased the older data. Our current best estimate of the Solar System primordial Pb is that of Nantan troilite, which has the following isotopic composition: 204Pb/ 206Pb = 0.107459(16), 207Pb/ 206Pb = 1.10759(10), and 208Pb/ 206Pb = 3.17347(28). This is slightly less radiogenic than the intercept of the bundle of isotopic arrays formed in 207Pb/ 206Pb- 204Pb/ 206Pb space by our measurements of Canyon Diablo, Nantan, Seeläsgen, Cape York, and Mundrabilla, as well as literature data, which, in spite of rather large uncertainties, suggests a common primordial Pb component for all of these meteorites. The radiogenic Pb present in most of these irons is dominantly

  19. De Novo GMNN Mutations Cause Autosomal-Dominant Primordial Dwarfism Associated with Meier-Gorlin Syndrome

    NARCIS (Netherlands)

    Burrage, L.C.; Charng, W.L.; Eldomery, M.K.; Willer, J.R.; Davis, E.E.; Lugtenberg, D.; Zhu, W.; Leduc, M.S.; Akdemir, Z.C.; Azamian, M.; Zapata, G.; Hernandez, P.P.; Schoots, J.; Munnik, S.A. de; Roepman, R.; Pearring, J.N.; Jhangiani, S.; Katsanis, N.; Vissers, L.E.L.M.; Brunner, H.G.; Beaudet, A.L.; Rosenfeld, J.A.; Muzny, D.M.; Gibbs, R.A.; Eng, C.M.; Xia, F.; Lalani, S.R.; Lupski, J.R.; Bongers, E.M.H.F.; Yang, Y

    2015-01-01

    Meier-Gorlin syndrome (MGS) is a genetically heterogeneous primordial dwarfism syndrome known to be caused by biallelic loss-of-function mutations in one of five genes encoding pre-replication complex proteins: ORC1, ORC4, ORC6, CDT1, and CDC6. Mutations in these genes cause disruption of the origin

  20. Primordial function and ambiguity in its determination

    CERN Document Server

    Petrov, V K

    2003-01-01

    We study the possibility to reconstruct the primordial function for some periodic function. The procedure includes an analytical continuation of a discrete function for Fourier coefficients computation, that introduces an ambiguity. To establish conditions under which no ambiguity appears, the modification of Carlson theorem is suggested. In a case when no subsidiary condition is imposed, ambiguity in the definition of primordial function does not go beyond the functions which belong to space $\\Omega^{\\prime}$.

  1. Primordial black hole formation from cosmological fluctuations

    CERN Document Server

    Harada, Tomohiro

    2016-01-01

    Primordial black holes (PBHs) are those which may have formed in the early Universe and affected the subsequent evolution of the Universe through their Hawking radiation and gravitational field. To constrain the early Universe from the observational constraint on the abundance of PBHs, it is essential to determine the formation threshold for primordial cosmological fluctuations, which are naturally described by cosmological long-wavelength solutions. I will briefly review our recent analytical and numerical results on the PBH formation.

  2. The Challenges and Relevance of Exploring the Genetics of North Africa’s “Barbary Lion” and the Conservation of Putative Descendants in Captivity

    Directory of Open Access Journals (Sweden)

    Simon A. Black

    2016-01-01

    Full Text Available The lions of North Africa were unique in ecological terms as well as from a human cultural perspective and were the definitive lions of Roman and Medieval Europe. Labelled “Barbary” lions, they were once numerous in North Africa but were exterminated by the mid-20th century. Despite subsequent degeneration of the Atlas Mountain ecosystem through human pressures, the feasibility of lion reintroduction has been debated since the 1970s. Research on the long-established captive lion collection traditionally kept by the sultans and kings of Morocco has enabled selective breeding coordinated across Moroccan and European zoos involving a significant number of animals. Molecular genetic research has recently provided insights into lion phylogeny which, despite previous suggestions that all lions share recent common ancestry, now indicates clear distinctions between lions in North, West, and Central Africa, the Middle East, and India versus those in Southern and Eastern Africa. A review of the evolutionary relevance of North African lions highlights the important challenges and opportunities in understanding relationships between Moroccan lions, extinct North African lions, and extant lion populations in India and West and Central Africa and the potential role for lions in ecosystem recovery in those regions.

  3. The Challenges and Relevance of Exploring the Genetics of North Africa's “Barbary Lion” and the Conservation of Putative Descendants in Captivity

    Science.gov (United States)

    2016-01-01

    The lions of North Africa were unique in ecological terms as well as from a human cultural perspective and were the definitive lions of Roman and Medieval Europe. Labelled “Barbary” lions, they were once numerous in North Africa but were exterminated by the mid-20th century. Despite subsequent degeneration of the Atlas Mountain ecosystem through human pressures, the feasibility of lion reintroduction has been debated since the 1970s. Research on the long-established captive lion collection traditionally kept by the sultans and kings of Morocco has enabled selective breeding coordinated across Moroccan and European zoos involving a significant number of animals. Molecular genetic research has recently provided insights into lion phylogeny which, despite previous suggestions that all lions share recent common ancestry, now indicates clear distinctions between lions in North, West, and Central Africa, the Middle East, and India versus those in Southern and Eastern Africa. A review of the evolutionary relevance of North African lions highlights the important challenges and opportunities in understanding relationships between Moroccan lions, extinct North African lions, and extant lion populations in India and West and Central Africa and the potential role for lions in ecosystem recovery in those regions. PMID:27656310

  4. Genetic susceptibility on CagA-interacting molecules and gene-environment interaction with phytoestrogens: a putative risk factor for gastric cancer.

    Directory of Open Access Journals (Sweden)

    Jae Jeong Yang

    Full Text Available OBJECTIVES: To evaluate whether genes that encode CagA-interacting molecules (SRC, PTPN11, CRK, CRKL, CSK, c-MET and GRB2 are associated with gastric cancer risk and whether an interaction between these genes and phytoestrogens modify gastric cancer risk. METHODS: In the discovery phase, 137 candidate SNPs in seven genes were analyzed in 76 incident gastric cancer cases and 322 matched controls from the Korean Multi-Center Cancer Cohort. Five significant SNPs in three genes (SRC, c-MET and CRK were re-evaluated in 386 cases and 348 controls in the extension phase. Odds ratios (ORs for gastric cancer risk were estimated adjusted for age, smoking, H. pylori seropositivity and CagA strain positivity. Summarized ORs in the total study population (462 cases and 670 controls were presented using pooled- and meta-analysis. Plasma concentrations of phytoestrogens (genistein, daidzein, equol and enterolactone were measured using the time-resolved fluoroimmunoassay. RESULTS: SRC rs6122566, rs6124914, c-MET rs41739, and CRK rs7208768 showed significant genetic effects for gastric cancer in both the pooled and meta-analysis without heterogeneity (pooled OR = 3.96 [95% CI 2.05-7.65], 1.24 [95% CI = 1.01-1.53], 1.19 [95% CI = 1.01-1.41], and 1.37 [95% CI = 1.15-1.62], respectively; meta OR = 4.59 [95% CI 2.74-7.70], 1.36 [95% CI = 1.09-1.70], 1.20 [95% CI = 1.00-1.44], and 1.32 [95% CI = 1.10-1.57], respectively. Risk allele of CRK rs7208768 had a significantly increased risk for gastric cancer at low phytoestrogen levels (p interaction<0.05. CONCLUSIONS: Our findings suggest that SRC, c-MET and CRK play a key role in gastric carcinogenesis by modulating CagA signal transductions and interaction between CRK gene and phytoestrogens modify gastric cancer risk.

  5. On primordial sense-antisense coding.

    Science.gov (United States)

    Rodin, Andrei S; Rodin, Sergei N; Carter, Charles W

    2009-11-01

    The genetic code is implemented by aminoacyl-tRNA synthetases (aaRS). These 20 enzymes are divided into two classes that, despite performing same functions, have nothing common in structure. The mystery of this striking partition of aaRSs might have been concealed in their sterically complementary modes of tRNA recognition that, as we have found recently, protect the tRNAs with complementary anticodons from confusion in translation. This finding implies that, in the beginning, life increased its coding repertoire by the pairs of complementary codons (rather than one-by-one) and used both complementary strands of genes as templates for translation. The class I and class II aaRSs may represent one of the most important examples of such primordial sense-antisense (SAS) coding (Rodin and Ohno, Orig Life Evol Biosph 25:565-589, 1995). In this report, we address the issue of SAS coding in a wider scope. We suggest a variety of advantages that such coding would have had in exploring a wider sequence space before translation became highly specific. In particular, we confirm that in Achlya klebsiana a single gene might have originally coded for an HSP70 chaperonin (class II aaRS homolog) and an NAD-specific GDH-like enzyme (class I aaRS homolog) via its sense and antisense strands. Thus, in contrast to the conclusions in Williams et al. (Mol Biol Evol 26:445-450, 2009), this could indeed be a "Rosetta stone" gene (Carter and Duax, Mol Cell 10:705-708, 2002) (eroded somewhat, though) for the SAS origin of the two aaRS classes.

  6. À Procura da Unidade Primordial

    Directory of Open Access Journals (Sweden)

    Debora Pazetto Ferreira

    2009-06-01

    Full Text Available O presente artigo tem como objetivo uma abordagem crítica de um dos primeiros ensaios de Hölderlin, escrito por volta de 1794-5, intitulado Juízo e Ser. Nesse período, fundamentar o sistema kantiano através de um primeiro princípio tornou-se um dos principais incentivos dos desenvolvimentos teóricos do idealismo alemão. A filosofia de Fichte e Schelling, bem como a de Hölderlin, podem ser compreendidas por esse viés. Entretanto, o último chega a soluções bastante diferentes dos demais, culminando com a negação da possibilidade de um princípio unificador para qualquer sistema filosófico. Assim, contra os incessantes esforços dos idealistas alemães para apreender a totalidade do real em termos conceituais, através de um primeiro princípio, normalmente caracterizado como o Eu, o Sujeito, o Eu absoluto, Hölderlin defende a incognoscibilidade de qualquer conceito unificante do real. A realidade enquanto unidade primordial não pode ser apanhada pelo discurso teórico, nem conhecida, nem aprisionada em conceitos, revelando-se apenas através de uma intuição intelectual de cunho estético. Esse conceito eminentemente anti-kantiano constitui a peça chave para o entendimento do pensamento hölderliniano. Ele justifica, em última instância, o privilégio da poesia e da linguagem poética em detrimento do discurso conceitual e mostra, com isso, que há uma coerência interna entre os ensaios teóricos de Hölderlin e suas obras literárias.

  7. The two classes of primordial follicles in the mouse ovary: their development, physiological functions and implications for future research.

    Science.gov (United States)

    Zheng, Wenjing; Zhang, Hua; Liu, Kui

    2014-04-01

    Ovarian follicles are the basic functional units in the mammalian ovary. This review summarizes early pioneering studies and focuses on recent progress that has shown that there are two distinct classes of primordial follicles in the ovary: the first wave of primordial follicles that are activated immediately after they are formed and the adult primordial follicles that are activated gradually in later life. These two separate classes have been proposed for two decades, but sufficient experimental evidence to support this hypothesis has only been obtained recently using newly developed follicular tracing techniques in genetically modified mouse models. These two follicle populations differ from each other primarily in terms of their developmental dynamics and their contributions to ovarian physiology. It is apparent now that these two follicle populations should be treated separately, and such knowledge will hopefully lead to a more in-depth understanding of how distinct types of primordial follicles contribute to physiologic and pathologic alterations of the mammalian ovary.

  8. Rapamycin-sensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary.

    Science.gov (United States)

    Tong, Yuanyuan; Li, Fei; Lu, Yi; Cao, Yanlan; Gao, Jimin; Liu, Jianghuai

    2013-12-01

    In mammals, resting female oocytes reside in primordial ovarian follicles. An individual primordial follicle may stay quiescent for a protracted period of time before initiating follicular growth, which is also termed “activation.” Female reproductive capacity is sustained by the gradual, streamlined activation of the entire population of primordial follicles, but this process also results in reproductive senescence in older animals. Based on the recent findings that genetically triggered, excessive mammalian target of rapamycin complex 1 (mTORC1) activation in mouse oocytes leads to accelerated primordial follicle activation, we examined the necessity of mTORC1 signaling in physiological primordial follicle activation. We found that induction of oocyte mTORC1 activity is associated with early follicular growth in neonatal mouse ovaries. Pharmacological inhibition of mTORC1 activity in vivo by rapamycin treatment leads to a marked, but partial, suppression of primordial follicle activation. The suppressive effect of rapamycin on primordial follicle activation was reproduced in cultured ovaries. While rapamycin did not apparently affect several plausible cellular targets in neonatal mouse ovaries, such as mTORC2, AKT, or cyclin-dependent kinase (CDK) inhibitor p27-KIP1, its inhibitory effect on Cyclin A2 gene expression implies that mTORC1 signaling in oocytes may engage a Cyclin A/CDK regulatory network that promotes primordial follicle activation. The current work strengthens the concept that mTORC1-dependent events in the oocytes of primordial follicles may represent potential targets for intervention in humans to slow the depletion of the ovarian reserve. © 2013 Wiley Periodicals, Inc.

  9. Control of ovarian primordial follicle activation

    Science.gov (United States)

    2012-01-01

    The ovarian follicles develop initially from primordial follicles. The majority of ovarian primordial follicles are maintained quiescently as a reserve for the reproductive life span. Only a few of them are activated and develop to an advanced follicular stage. The maintenance of dormancy and activation of primordial follicles are controlled by coordinated actions of a suppressor/activator with close communications with somatic cells and intra-oocyte signaling pathways. Many growth factors and signaling pathways have been identified and the transforming growth factor-beta superfamily plays important roles in early folliculogenesis. However, the mechanism of maintaining the dormancy and survival of primordial follicles has remained unknown for decades. Recently, since the first finding that all primordial follicles are activated prematurely in mice deficient forkhead box O3a, phosphatidylinositol 3 kinase/phosphatase and tensin homolog (PTEN) signaling pathway was reported to be important in the regulation of dormancy and initial follicular activation. With these informations on early folliculogenesis, clinical application can be expected such as in vitro maturation of immature oocytes or in vitro activation of follicles by PTEN inhibitor in cryopreserved ovarian cortical tissues for fertility preservation. PMID:22563545

  10. Nonthermal WIMPs and primordial black holes

    Science.gov (United States)

    Georg, Julian; Şengör, Gizem; Watson, Scott

    2016-06-01

    Nonthermal histories for the early universe have received notable attention as they are a rich source of phenomenology, while also being well motivated by top-down approaches to beyond the Standard Model physics. The early (pre-big bang nucleosynthesis) matter phase in these models leads to enhanced growth of density perturbations on sub-Hubble scales. Here, we consider whether primordial black hole formation associated with the enhanced growth is in conflict with existing observations. Such constraints depend on the tilt of the primordial power spectrum, and we find that nonthermal histories are tightly constrained in the case of a significantly blue spectrum. Alternatively, if dark matter is taken to be of nonthermal origin, we can restrict the primordial power spectrum on scales inaccessible to cosmic microwave background and large scale structure observations. We establish constraints for a wide range of scalar masses (reheat temperatures) with the most stringent bounds resulting from the formation of 1015 g black holes. These black holes would be evaporating today and are constrained by FERMI observations. We also consider whether the breakdown of the coherence of the scalar oscillations on subhorizon scales can lead to a Jean's pressure preventing black hole formation and relaxing our constraints. Our main conclusion is that primordial black hole constraints, combined with existing constraints on nonthermal weakly interacting massive particles, favor a primordial spectrum closer to scale invariance or a red tilted spectrum.

  11. PIPER: Primordial Inflation Polarization Explorer

    Science.gov (United States)

    Lazear, Justin; Ade, P.; Benford, D. J.; Bennett, C. L.; Chuss, D. T.; Dotson, J. L.; Eimer, J.; Fixsen, D. J.; Halpern, M.; Hinderks, J.; Hinshaw, G. F.; Irwin, K.; Jhabvala, C.; Johnson, B.; Kogut, A. J.; Mirel, P.; Moseley, S. H.; Staguhn, J.; Switzer, E.; Tucker, C. E.; Weston, A.; Wollack, E.

    2014-01-01

    The Primordial Inflation Polarization ExploreR (PIPER) is a balloon-borne cosmic microwave background (CMB) polarization experiment searching for large-angular scale B-mode polarization to constrain Inflation in the early universe. The Inflationary Big Bang theory predicts that the epoch of inflation will result in a background of gravitational waves. These gravitational waves imprinted their unique B-mode signature on the CMB polarization, two features of which are a peak at ell ~ 80 and a "bump" below ell ~ 10 in the B-mode angular power spectrum. The ell ~ 80 "recombination" peak is the first peak caused by gravitational waves imprinting tensor (B-mode) perturbations onto the CMB spectrum during recombination. Gravitational waves at larger scales have not yet entered the horizon and may not contribute, and at smaller scales have decayed away by other interactions, giving rise to a peak at horizon scale. The ell ~ 10 "reionization" bump is caused by a similar mechanism as the recombination peak, where gravitational waves imprint B-mode perturbations into the spectrum, now at larger horizon scales. PIPER will target the reionization bump while keeping enough angular resolution to measure the recombination peak, with sensitivity down to tensor-to-scalar ratio r = 0.007. A series of flights alternating between north and south will produce nearly full-sky temperature and polarization maps and measure the low-ell spectra. 5120 transition edge sensor (TES) bolometers each with 20 arcmin beamwidth, distributed into 4 rectangular close-packed arrays maintained at 150 mK will provide small-scale resolution and sensitivity. PIPER consists of two co-aligned telescopes, each with a front-end variable-delay polarization modulator rapidly modulating either the Q or U Stokes parameters to provide polarization sensitivity and mitigate systematic errors. To achieve background-limited sensitivity, the entire instrument is enclosed in an open bucket dewar maintained at 1.5 K. PIPER

  12. Axion production from primordial magnetic fields

    Science.gov (United States)

    Kamada, Kohei; Nakai, Yuichiro

    2017-07-01

    Production of axionlike particles (ALPs) by primordial magnetic fields may have significant impacts on cosmology. We discuss the production of ALPs in the presence of the primordial magnetic fields. We find a region of the ALP mass and photon coupling which realizes the observed properties of the dark matter with appropriate initial conditions for the magnetic fields. This region may be interesting in light of recent indications for the 3.5 keV lines from galaxy clusters. For a small axion mass, a region of previously allowed parameter spaces is excluded by overproduction of ALPs as a hot/warm dark matter component. Since the abundance of ALPs strongly depends on the initial conditions of primordial magnetic fields, our results provide implications for scenarios of magnetogenesis.

  13. CMB anisotropies from primordial inhomogeneous magnetic fields

    CERN Document Server

    Lewis, A

    2004-01-01

    Primordial inhomogeneous magnetic fields of the right strength can leave a signature on the CMB temperature anisotropy and polarization. Potentially observable contributions to polarization B-modes are generated by vorticity and gravitational waves sourced by the magnetic anisotropic stress. We compute the corresponding CMB transfer functions in detail including the effect of neutrinos. The shear rapidly causes the neutrino anisotropic stress to cancel the stress from the magnetic field, suppressing the production of gravitational waves and vorticity on super-horizon scales after neutrino decoupling. A significant large scale signal from tensor modes can only be produced before neutrino decoupling, and the actual amplitude is somewhat uncertain. Plausible values suggest primordial nearly scale invariant fields of ~ 10^(-10)G today may be observable from their large scale tensor anisotropy. They can be distinguished from primordial gravitational waves by their non-Gaussianity. Vector mode vorticity sources B-m...

  14. Strong Primordial Inhomogeneities and Galaxy Formation

    CERN Document Server

    Khlopov, M Ya; Sakharov, Alexander S

    2002-01-01

    The new element of theory of galaxy formation, strong primordial inhomogeneities, is shown to be a reflection of unstable large scale structures of topological defects, created in second order phase transitions in the inflationary Universe. In addition to {\\it archioles-like} large scale correlation of the primordial inhomogeneity of energy density of coherent scalar field oscillations, the same mechanism, based on the second order phase transitions on the inflational stage and the domain wall formation upon the end of inflation, leads to the formation of massive black hole clusters that can serve as nuclei for the future galaxies. The number of black holes with $M \\sim 100M_{\\odot}$ and above is comparable with the number of galaxies within the modern cosmological horizon. The primordial fractal structure of galaxies can find natural grounds in the framework of model we developed . The proposed approach offers the physical basis for new scenarios of galaxy formation in the Big Bang Universe.

  15. Primordial Germ Cell Specification and Migration

    Science.gov (United States)

    Marlow, Florence

    2015-01-01

    Primordial germ cells are the progenitor cells that give rise to the gametes. In some animals, the germline is induced by zygotic transcription factors, whereas in others, primordial germ cell specification occurs via inheritance of maternally provided gene products known as germ plasm. Once specified, the primordial germ cells of some animals must acquire motility and migrate to the gonad in order to survive. In all animals examined, perinuclear structures called germ granules form within germ cells. This review focuses on some of the recent studies, conducted by several groups using diverse systems, from invertebrates to vertebrates, which have provided mechanistic insight into the molecular regulation of germ cell specification and migration. PMID:26918157

  16. Primordial Black Holes from First Principles (Overview)

    Science.gov (United States)

    Lam, Casey; Bloomfield, Jolyon; Moss, Zander; Russell, Megan; Face, Stephen; Guth, Alan

    2017-01-01

    Given a power spectrum from inflation, our goal is to calculate, from first principles, the number density and mass spectrum of primordial black holes that form in the early universe. Previously, these have been calculated using the Press- Schechter formalism and some demonstrably dubious rules of thumb regarding predictions of black hole collapse. Instead, we use Monte Carlo integration methods to sample field configurations from a power spectrum combined with numerical relativity simulations to obtain a more accurate picture of primordial black hole formation. We demonstrate how this can be applied for both Gaussian perturbations and the more interesting (for primordial black holes) theory of hybrid inflation. One of the tools that we employ is a variant of the BBKS formalism for computing the statistics of density peaks in the early universe. We discuss the issue of overcounting due to subpeaks that can arise from this approach (the ``cloud-in-cloud'' problem). MIT UROP Office- Paul E. Gray (1954) Endowed Fund.

  17. Dark energy from primordial inflationary quantum fluctuations.

    Science.gov (United States)

    Ringeval, Christophe; Suyama, Teruaki; Takahashi, Tomo; Yamaguchi, Masahide; Yokoyama, Shuichiro

    2010-09-17

    We show that current cosmic acceleration can be explained by an almost massless scalar field experiencing quantum fluctuations during primordial inflation. Provided its mass does not exceed the Hubble parameter today, this field has been frozen during the cosmological ages to start dominating the Universe only recently. By using supernovae data, completed with baryonic acoustic oscillations from galaxy surveys and cosmic microwave background anisotropies, we infer the energy scale of primordial inflation to be around a few TeV, which implies a negligible tensor-to-scalar ratio of the primordial fluctuations. Moreover, our model suggests that inflation lasted for an extremely long period. Dark energy could therefore be a natural consequence of cosmic inflation close to the electroweak energy scale.

  18. Models of the Primordial Standard Clock

    CERN Document Server

    Chen, Xingang; Wang, Yi

    2014-01-01

    Oscillating massive fields in the primordial universe can be used as Standard Clocks. The ticks of these oscillations induce features in the density perturbations, which directly record the time evolution of the scale factor of the primordial universe, thus if detected, provide a direct evidence for the inflation scenario or the alternatives. In this paper, we construct a full inflationary model of primordial Standard Clock and study its predictions on the density perturbations. This model provides a full realization of several key features proposed previously. We compare the theoretical predictions from inflation and alternative scenarios with the Planck 2013 temperature data on Cosmic Microwave Background (CMB), and identify a statistically marginal but interesting candidate. We discuss how future CMB temperature and polarization data, non-Gaussianity analysis and Large Scale Structure data may be used to further test or constrain the Standard Clock signals.

  19. Fugacity and Reheating of Primordial Neutrinos

    CERN Document Server

    Birrell, Jeremiah; Chen, Pisin; Rafelski, Johann

    2013-01-01

    We report a deviation from chemical equilibrium in the primordial neutrino distribution that arises naturally before BBN as the electron mass $m_e$ becomes an important scale. The cause is a drop in the deceleration parameter of the universe when $T\\simeq m_e$ combined with the distinct neutrino freeze-out temperatures that satisfy the condition $T_c > m_e > T_k$, where $T_c$ is the neutrino chemical freeze-out temperature and $T_k$ that for the kinetic freeze-out. This effect is described by a primordial neutrino fugacity $\\Upsilon_\

  20. Primordial Features as Evidence for Inflation

    CERN Document Server

    Chen, Xingang

    2011-01-01

    In the primordial universe, particles with mass much larger than the mass-scale of the event-horizon (such as the Hubble parameter in inflation) exist ubiquitously, and can be excited from time to time and oscillate quickly around its minimum. These excitations can induce specific patterns in density perturbations, which record the time dependence of the scale factor of the primordial universe, thus provide direct evidence for the inflationary epoch or its alternatives. Such effects are conventionally integrated out in theoretical and data analyses, but can be accessible for experiments targeting on density perturbations with high multiples.

  1. Growth of primordial oocytes in neonatal and adult mammals.

    Science.gov (United States)

    Moniruzzaman, Mohammad; Miyano, Takashi

    2010-12-01

    Mammalian ovaries are endowed with a huge number of small oocytes (primordial oocytes) in primordial follicles. A small number of primordial oocytes start to grow, while others remain quiescent. Little is known about the mechanism regulating the activation of primordial oocytes. Recently, we found that primordial follicles in mature cows and prepubertal pigs took longer to initiate growth in xenografts compared with those in neonatal animals. We think that primordial oocytes in adult mammals are different from those in neonatal mammals. In this review, we summarize the results regarding the activation of primordial oocytes in neonatal and adult ovaries of different species and propose a model in which ovaries of neonatal mammals contain a mixed population of both quiescent and activated primordial oocytes, while almost all primordial oocytes are quiescent in adult females. The dormancy of primordial oocytes may be required to reserve the non-growing oocyte pool for the long reproductive life in mammals. FOXO3 is considered one of the molecules responsible for the dormancy of primordial oocytes in adult ovaries. These quiescent primordial oocytes are activated, perhaps by certain mechanisms involving the interaction between stimulatory and inhibitory factors, to enter the growth phase.

  2. Primordial black holes as a novel probe of primordial gravitational waves II: detailed analysis

    CERN Document Server

    Nakama, Tomohiro

    2016-01-01

    Recently we have proposed a novel method to probe primordial gravitational waves from upper bounds on the abundance of primordial black holes (PBHs). When the amplitude of primordial tensor perturbations generated in the early universe is very large, they induce large scalar perturbations due to their second-order effects. If the amplitude of resultant scalar perturbations is too large at the moment of their horizon reenty, then PBHs are overproduced to a level that is inconsistent with a variety of existing observations constraining the abundance of PBHs. This consideration leads to upper bounds on the amplitude of primordial tensor perturbations on super-horizon scales. In contrast to our recent paper in which we only present simple estimations of the upper bounds from PBHs, in this paper, we present detailed derivations, by solving the Einstein equations for scalar perturbations induced at second order in tensor perturbations. We also derive an approximate formula for the probability density function of in...

  3. Primordial black holes do not (yet) constrain the primordial power spectrum

    CERN Document Server

    Akrami, Yashar; Sandstad, Marit

    2016-01-01

    Primordial black holes (PBHs) are thought to have formed from extremely overdense regions that reentered the horizon after the end of inflation if there was sufficient power in primordial perturbations on specific scales. The existence (and abundance) of PBHs is therefore governed by the inflationary power spectrum. So far no primordial black holes have been observed, and instead, increasingly stringent bounds on their existence at different scales have been set. Up until recently this has been exploited in attempts to constrain parts of the inflationary power spectrum that are unconstrained by the cosmic microwave background and other cosmological observations. In this letter we point out that this simple translation of the PBH constraints into constraints on the primordial power spectrum is inaccurate as it fails to take into account realistic aspects of the PBH formation and evolution process. We show this by displaying a concrete example of a power spectrum that is seemingly in conflict with the constrain...

  4. The primordial binary population in ob associations

    Directory of Open Access Journals (Sweden)

    M. B. N. Kouwenhoven

    2004-01-01

    Full Text Available Presentamos los primeros resultados de nuestro sondeo con optica adaptativa de 200 estrellas principalmente de tipo A en la asociaci on OB cercana Sco OB2. Estos resultados, junto con datos de la literatura y simulaciones detalladas de c umulos j ovenes, ser an utilizados para determinar la poblaci on primordial de binarias.

  5. The Primordial Binary Population in OB Associations

    NARCIS (Netherlands)

    Kouwenhoven, M.B.N.; Brown, A.G.A.; Gualandris, A.; Kaper, L.; Portegies Zwart, S.F.; Zinnecker, H.; Allen, C.; Scarfe, C.

    2004-01-01

    We present the first results of our adaptive optics survey of 200 (mainly) A-type stars in the nearby OB association Sco OB2, which we will use, together with literature data and detailed simulations of young star clusters, to determine the primordial binary population.

  6. The Formation of Primordial Luminous Objects

    NARCIS (Netherlands)

    Ripamont, E.; Abel, T.

    2005-01-01

    Abstract: In these lecture notes we review the current knowledge about the formation of the first luminous objects. We start from the cosmological context of hierarchical models of structure formation, and discuss the main physical processes which are believed to lead to primordial star formation,

  7. Isolation and culture of chicken primordial follicles.

    Science.gov (United States)

    Leghari, Imdad Hussain; Zhao, Dan; Mi, Yuling; Zhang, Caiqiao

    2015-10-01

    The establishment of a primordial follicle culture system is important for the study of follicular development. Hence, the objective of this study was to isolate chicken primordial follicles and establish culture methods. Ovaries from 2-wk-old chickens were treated with trypsin-EDTA, collagenase II, or collagenase type IA, along with a mechanical isolation technique. Isolated follicles were cultured under different conditions. Results showed a significant difference in the follicular recovery and survival rates among different enzymes and methods used. The maximal follicular yield was obtained by trypsin+EDTA and collagenase II digestion, followed by collagenase type IA digestion. However, the highest follicular viability rate was observed in groups of collagenase type IA digestion and the mechanical isolation method. Enzymatic treatment resulted in higher misshapen oocytes or follicles, though the diameters of the follicles were not significantly changed. In addition, our follicle culture results for different conditions showed maximal survival rates of primordial follicles in alginate hydrogel beads after 12 d of culture. Thus, we successfully established methods for isolating and culturing chicken primordial follicles. The present method will greatly facilitate investigation of the regulation of follicular development. © 2015 Poultry Science Association Inc.

  8. Primordial Prevention of Cardiometabolic Risk in Childhood.

    Science.gov (United States)

    Tanrikulu, Meryem A; Agirbasli, Mehmet; Berenson, Gerald

    2017-01-01

    Fetal life and childhood are important in the development of cardiometabolic risk and later clinical disease of atherosclerosis, hypertension and diabetes mellitus. Molecular and environmental conditions leading to cardiometabolic risk in early life bring us a challenge to develop effective prevention and intervention strategies to reduce cardiovascular (CV) risk in children and later disease. It is important that prevention strategies begin at an early age to reduce future CV morbidity and mortality. Pioneering work from longitudinal studies such as Bogalusa Heart Study (BHS), the Finnish Youth Study and other programs provide an awareness of the need for public and health services to begin primordial prevention. The impending CV risk beginning in childhood has a significant socioeconomic burden. Directions to achieve primordial prevention of cardiometabolic risk in children have been developed by prior longitudinal studies. Based on those studies that show risk factors in childhood as precursors of adult CV risk, implementation of primordial prevention will have effects at broad levels. Considering the epidemic of obesity, the high prevalence of hypertension and cardiometabolic risk, prevention early in life is valuable. Comprehensive health education, such as 'Health Ahead/Heart Smart', for all elementary school age children is one approach to begin primordial prevention and can be included in public education beginning in kindergarten along with the traditional education subject matter.

  9. The Primordial Binary Population in OB Associations

    NARCIS (Netherlands)

    Kouwenhoven, M.B.N.; Brown, A.G.A.; Gualandris, A.; Kaper, L.; Portegies Zwart, S.F.; Zinnecker, H.; Allen, C.; Scarfe, C.

    2004-01-01

    We present the first results of our adaptive optics survey of 200 (mainly) A-type stars in the nearby OB association Sco OB2, which we will use, together with literature data and detailed simulations of young star clusters, to determine the primordial binary population.

  10. Primordial gravitational waves, BICEP2 and beyond

    Indian Academy of Sciences (India)

    L Sriramkumar

    2016-02-01

    Observations of the imprints of primordial gravitational waves on the anisotropies in the cosmic microwave background can provide us with unambiguous clues to the physics of the very early Universe. In this brief article, the implications of the detection of such signatures for the inflationary scenario has been discussed.

  11. Mirror matter and primordial black holes

    OpenAIRE

    Bell, Nicole F.; Volkas, Raymond R.

    1998-01-01

    A consequence of the evaporation of primordial black holes in the early universe may be the generation of mirror matter. This would have implications with regard to dark matter, and the number of light particle species in equilibrium at the time of big bang nucleosynthesis. The possibilities for the production of mirror matter by this mechanism are explored.

  12. Primordial tensor modes from quantum corrected inflation

    DEFF Research Database (Denmark)

    Joergensen, Jakob; Sannino, Francesco; Svendsen, Ole

    2014-01-01

    . Finally we confront these theories with the Planck and BICEP2 data. We demonstrate that the discovery of primordial tensor modes by BICEP2 require the presence of sizable quantum departures from the $\\phi^4$-Inflaton model for the non-minimally coupled scenario which we parametrize and quantify. We...

  13. New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators.

    Science.gov (United States)

    Sun, Xinhui; Su, Yiping; He, Yuanlin; Zhang, Jing; Liu, Wenwen; Zhang, Huilin; Hou, Zheng; Liu, Jiayin; Li, Jing

    2015-01-01

    It had been known for decades that primordial follicles in mammalian ovaries are assembled with definite numbers and represent the ovarian reserve throughout the reproductive life. Intra-oocyte PI3K/mTOR pathways have been indicated to play a central role on the activation of primordial follicles. Genetic modified mouse models with chronic activation of PI3K/mTOR signals in primordial oocytes showed premature activation of all primordial follicles and eventually their exhaustion. On the other hand, this may suggest that, unlike chronic activation of PI3K/mTOR, its acute activation in infertility would activate primordial follicles, permitting fertility during the treatment. Previously, PI3K stimulators were reported as a temporary measure to accelerate primordial follicle activation and follicular development in both mouse and human, and were applied in the treatment of infertility in premature ovarian failure (POF) patients. To address whether mTOR stimulators could play similar role in the process, we transiently treated neonatal and aged mouse ovaries with mTOR stimulators-phosphatidic acid (PA) and propranolol. Our results demonstrated the stimulators increased activation of primordial follicles and the production of progeny. Human ovarian cortex cubes were also treated with mTOR or/and PI3K stimulators in vitro. When they were used separately, both of them showed similar promotive effects on primordial follicles. Surprisingly, after joint-treatment with the 2 kinds of stimulators together, synergistic effects on follicular development were observed. Based on increased efficiency of follicular activation in humans, here we propose in vitro transient treatment with mTOR and PI3K stimulators as an optimized protocol for the application in different clinical conditions with limited follicle reserve.

  14. Genetics

    Science.gov (United States)

    ... Inheritance; Heterozygous; Inheritance patterns; Heredity and disease; Heritable; Genetic markers ... The chromosomes are made up of strands of genetic information called DNA. Each chromosome contains sections of ...

  15. Expression of ErbB3-binding protein-1 (EBP1) during primordial follicle formation: role of estradiol-17ß.

    Science.gov (United States)

    Mukherjee, Anindit; Roy, Shyamal K

    2013-01-01

    The formation of primordial follicles involves the interaction between the oocytes and surrounding somatic cells, which differentiate into granulosa cells. Estradiol-17ß (E) promotes primordial follicle formation in vivo and in vitro; however, the underlying mechanisms are poorly understood. The expression of an ERBB3-binding protein 1 (EBP1) is downregulated in 8-day old hamster ovaries concurrent with the increase in serum estradiol levels and the formation of primordial follicles. The objectives of the present study were to determine the spatio-temporal expression and putative E regulation of EBP1 in ovarian cells during perinatal development with respect to primordial follicle formation. Hamster EBP1 nucleic acid and amino acid sequences were more than 93% and 98% similar, respectively, to those of mouse and human, and contained nucleolar localization signal, RNA-binding domain and several phosphorylation sites. EBP1 protein was present in somatic cells and oocytes from E15, and declined in oocytes by P1 and in somatic cells by P5. Thereafter, EBP1 expression increased through P7 with a transient decline on P8 primarily in interstitial cells. EBP1 mRNA levels mirrored protein expression pattern. E treatment on P1 and P4 upregulated EBP1 expression by P8 whereas E treatment on P4 downregulated it by 72 h suggesting a compensatory upregulation due to E pretreatment. Treatment with an FSH-antiserum, which suppressed primordial follicle formation, prevented the decline in EBP1 levels, and the effect was reversed by E treatment. Therefore, the results provide the first evidence that EBP1 may play an important role in mediating the effect of E in the differentiation of somatic cells into granulosa cells during primordial follicle formation.

  16. Expression of ErbB3-binding protein-1 (EBP1 during primordial follicle formation: role of estradiol-17ß.

    Directory of Open Access Journals (Sweden)

    Anindit Mukherjee

    Full Text Available The formation of primordial follicles involves the interaction between the oocytes and surrounding somatic cells, which differentiate into granulosa cells. Estradiol-17ß (E promotes primordial follicle formation in vivo and in vitro; however, the underlying mechanisms are poorly understood. The expression of an ERBB3-binding protein 1 (EBP1 is downregulated in 8-day old hamster ovaries concurrent with the increase in serum estradiol levels and the formation of primordial follicles. The objectives of the present study were to determine the spatio-temporal expression and putative E regulation of EBP1 in ovarian cells during perinatal development with respect to primordial follicle formation. Hamster EBP1 nucleic acid and amino acid sequences were more than 93% and 98% similar, respectively, to those of mouse and human, and contained nucleolar localization signal, RNA-binding domain and several phosphorylation sites. EBP1 protein was present in somatic cells and oocytes from E15, and declined in oocytes by P1 and in somatic cells by P5. Thereafter, EBP1 expression increased through P7 with a transient decline on P8 primarily in interstitial cells. EBP1 mRNA levels mirrored protein expression pattern. E treatment on P1 and P4 upregulated EBP1 expression by P8 whereas E treatment on P4 downregulated it by 72 h suggesting a compensatory upregulation due to E pretreatment. Treatment with an FSH-antiserum, which suppressed primordial follicle formation, prevented the decline in EBP1 levels, and the effect was reversed by E treatment. Therefore, the results provide the first evidence that EBP1 may play an important role in mediating the effect of E in the differentiation of somatic cells into granulosa cells during primordial follicle formation.

  17. The primordial helium abundance from updated emissivities

    CERN Document Server

    Aver, Erik; Porter, R L; Skillman, Evan D

    2013-01-01

    Observations of metal-poor extragalactic H II regions allow the determination of the primordial helium abundance, Y_p. The He I emissivities are the foundation of the model of the H II region's emission. Porter, Ferland, Storey, & Detisch (2012) have recently published updated He I emissivities based on improved photoionization cross-sections. We incorporate these new atomic data and update our recent Markov Chain Monte Carlo analysis of the dataset published by Izotov, Thuan, & Stasinska (2007). As before, cuts are made to promote quality and reliability, and only solutions which fit the data within 95% confidence level are used to determine the primordial He abundance. The previously qualifying dataset is almost entirely retained and with strong concordance between the physical parameters. Overall, an upward bias from the new emissivities leads to a decrease in Y_p. In addition, we find a general trend to larger uncertainties in individual objects (due to changes in the emissivities) and an increase...

  18. Primordial gravitational waves in supersolid inflation

    Science.gov (United States)

    Ricciardone, Angelo; Tasinato, Gianmassimo

    2017-07-01

    Supersolid inflation is a class of inflationary theories that simultaneously breaks time and space reparametrization invariance during inflation, with distinctive features for the dynamics of cosmological fluctuations. We investigate concrete realizations of such a scenario, including non-minimal couplings between gravity and the fields driving inflation. We focus in particular on the dynamics of primordial gravitational waves and discuss how their properties depend on the pattern of symmetry breaking that we consider. Tensor modes can have a blue spectrum, and for the first time we build models in which the squeezed limit of primordial tensor bispectra can be parametrically enhanced with respect to standard single-field scenarios. At leading order in a perturbative expansion, the tensor-to-scalar ratio depends only on the parameter controlling the breaking of space reparametrization. It is independent from the quantities controlling the breaking of time reparametrization, and this represents a difference with respect to standard single-field inflationary models.

  19. Are cometary nuclei primordial rubble piles?

    Science.gov (United States)

    Weissman, P. R.

    1986-01-01

    Whipple's icy conglomerate model for the cometary nucleus has had considerable sucess in explaining a variety of cometary phenomena such as gas production rates and nongravitational forces. However, as discussed here, both observational evidence and theoretical considerations suggest that the cometary nucleus may not be a well-consolidated single body, but may instead be a loosely bound agglomeration of smaller fragments, weakly bonded and subject to occasional or even frequent disruptive events. The proposed model is analogous to the 'rubble pile' model suggested for the larger main-belt asteroids, although the larger cometary fragments are expected to be primordial condensations rather than collisionally derived debris as in the asteroid case. The concept of cometary nuclei as primordial rubble piles is proposed as a modification of the basic Whipple model, not as a replacement for it.

  20. Primordial anisotropies from cosmic strings during inflation

    Science.gov (United States)

    Jazayeri, Sadra; Sadr, Alireza Vafaei; Firouzjahi, Hassan

    2017-07-01

    In this work, we study the imprint of an individual primordial cosmic string within a Hubble patch on the inflationary power spectrum. A straight cosmic string induces two distinct contributions to the curvature perturbations power spectrum. The first type of correction respects the translation invariance while violating isotropy. This generates quadrupolar statistical anisotropy in cosmic microwave background maps, which is constrained by the Planck data. The second contribution breaks both homogeneity and isotropy, generating a dipolar power asymmetry in the variance of temperature fluctuations with its amplitude falling on small scales. We show that the strongest constraint on the tension of primordial cosmic strings is obtained from the quadrupolar anisotropy and argue that the mass scale of the underlying theory responsible for the formation of the string cannot be much higher than the grand unified theory scale. The predictions for the diagonal and off-diagonal components of the cosmic microwave background angular power spectrum induced by the string are presented.

  1. Inflating Kahler Moduli and Primordial Magnetic Fields

    CERN Document Server

    Aparicio, Luis

    2016-01-01

    We study the production of primordial magnetic fields in inflationary models in type IIB string theory where the role of the inflaton is played by a Kahler modulus. We consider various possibilities to realise the Standard Model degrees of freedom in this setting and explicitly determine the time dependence of the inflaton coupling to the Maxwell term in the models. Using this we determine the strength and scale dependence of the magnetic fields generated during inflation. The usual "strong coupling problem" for primordial magnetogesis manifests itself by cycle sizes approaching the string scale, this appears in a certain class of fibre inflation models where the standard model is realised by wrapping D7-branes on cycles in the geometric regime.

  2. Inflating Kahler moduli and primordial magnetic fields

    Directory of Open Access Journals (Sweden)

    Luis Aparicio

    2017-05-01

    Full Text Available We study the production of primordial magnetic fields in inflationary models in type IIB string theory where the role of the inflaton is played by a Kahler modulus. We consider various possibilities to realise the Standard Model degrees of freedom in this setting and explicitly determine the time dependence of the inflaton coupling to the Maxwell term in the models. Using this we determine the strength and scale dependence of the magnetic fields generated during inflation. The usual “strong coupling problem” for primordial magnetogenesis manifests itself by cycle sizes approaching the string scale; this appears in a certain class of fibre inflation models where the standard model is realised by wrapping D7-branes on cycles in the geometric regime.

  3. Primordial Odontogenic Tumor: Report of a Case.

    Science.gov (United States)

    Slater, Lee J; Eftimie, Liviu F; Herford, Alan S

    2016-03-01

    Primordial odontogenic tumor (POT) was first described in 2014. It typically presents in the posterior mandible of a child or adolescent as a "dentigerous cyst-like" well-circumscribed radiolucency associated with an unerupted molar. POT consists of an ellipsoidal mass of dental papilla-like myxoid connective tissue entirely enveloped in a delicate membrane of ameloblastic epithelium. It shows features of a developing tooth with a huge dental papilla, and because it is devoid of dental hard tissue, it could be regarded a soft tissue odontoma. The lesion histologically mimics early (primordial) stages of tooth development. This report describes a case of POT and POT-like proliferations in an unrelated complex odontoma.

  4. Primordial gravitational waves in supersolid inflation

    CERN Document Server

    Ricciardone, Angelo

    2016-01-01

    Supersolid inflation is a class of inflationary theories that simultaneously breaks time and space reparameterization invariance during inflation, with distinctive features for the dynamics of cosmological fluctuations. We investigate concrete realisations of such a scenario, including non-minimal couplings between gravity and the scalars driving inflation. We focus in particular on the dynamics of primordial gravitational waves and discuss how their properties depend on the pattern of symmetry breaking that we consider. Tensor modes can have a blue spectrum, and for the first time we build models in which the squeezed limit of primordial tensor bispectra can be parametrically enhanced with respect to standard single-field scenarios. At leading order in a perturbative expansion, the tensor-to-scalar ratio depends only on the parameter controlling the breaking of space-reparameterization. It is independent from the quantities controlling the breaking of time-reparameterization, and this represents a difference...

  5. Shapes and features of the primordial bispectrum

    Science.gov (United States)

    Gong, Jinn-Ouk; Palma, Gonzalo A.; Sypsas, Spyros

    2017-05-01

    If time-dependent disruptions from slow-roll occur during inflation, the correlation functions of the primordial curvature perturbation should have scale-dependent features, a case which is marginally supported from the cosmic microwave background (CMB) data. We offer a new approach to analyze the appearance of such features in the primordial bispectrum that yields new consistency relations and justifies the search of oscillating patterns modulated by orthogonal and local templates. Under the assumption of sharp features, we find that the cubic couplings of the curvature perturbation can be expressed in terms of the bispectrum in two specific momentum configurations, for example local and equilateral. This allows us to derive consistency relations among different bispectrum shapes, which in principle could be tested in future CMB surveys. Furthermore, based on the form of the consistency relations, we construct new two-parameter templates for features that include all the known shapes.

  6. Primordial Inflation Polarization Explorer: Status and Plans

    Science.gov (United States)

    Kogut, Alan

    2009-01-01

    The Primordial Inflation Polarization Explorer is a balloon-borne instrument to measure the polarization of the cosmic microwave background in order to detect the characteristic signature of gravity waves created during an inflationary epoch in the early universe. PIPER combines cold /I.G K\\ optics, 5120 bolometric detectors, and rapid polarization modulation using VPM grids to achieve both high sensitivity and excellent control of systematic errors. I will discuss the current status and plans for the PIPER instrument.

  7. On primordial groups for the Green ring

    OpenAIRE

    Raggi-Cardenas, Alberto; Romero, Nadia

    2009-01-01

    Consider the Mackey functor assigning to each finite group G the Green ring of finitely generated kG-modules, where k is a field of characteristic p>0. Thevenaz foresaw in 1988 that the class of primordial groups for this functor is the family of k-Dress groups. In this paper we prove that this is true for the subfunctor defined by the Green ring of finitely generated kG-modules of trivial source.

  8. Polarizing primordial gravitational waves by parity violation

    CERN Document Server

    Wang, Anzhong; Zhao, Wen; Zhu, Tao

    2012-01-01

    We study primordial gravitational waves (PGWs) in the Horava-Lifshitz (HL) theory of quantum gravity, in which high-order spatial derivative terms, including the ones violating parity, generically appear in order to be UV complete. Because of the parity violation and non-adiabatic evolution, a large polarization of PGWs becomes possible, and it could be well within the range of detection for the forthcoming cosmic microwave background (CMB) observations.

  9. Primordial Evolution in the Finitary Process Soup

    OpenAIRE

    Gornerup, Olof; Crutchfield, James P.

    2007-01-01

    A general and basic model of primordial evolution--a soup of reacting finitary and discrete processes--is employed to identify and analyze fundamental mechanisms that generate and maintain complex structures in prebiotic systems. The processes--$\\epsilon$-machines as defined in computational mechanics--and their interaction networks both provide well defined notions of structure. This enables us to quantitatively demonstrate hierarchical self-organization in the soup in terms of complexity. W...

  10. Cosmological Magnetic Fields from Primordial Helical Seeds

    CERN Document Server

    Sigl, G

    2002-01-01

    Most early Universe scenarios predict negligible magnetic fields on cosmological scales if they are unprocessed during subsequent expansion of the Universe. We present a new numerical treatment of the evolution of primordial fields and apply it to weakly helical seeds as they occur in certain early Universe scenarios. We find that initial helicities not much larger than the baryon to photon number can lead to fields of about 10^{-13} Gauss with coherence scales slightly below a kilo-parsec today.

  11. Cosmological implications of Primordial Black Holes

    OpenAIRE

    Bernal, Jos\\' e Luis; Bellomo, Nicola; Raccanelli, Alvise; Verde, Licia

    2017-01-01

    The possibility that a relevant fraction of the dark matter might be comprised of Primordial Black Holes (PBHs) has been seriously reconsidered after LIGO's detection of a $\\sim 30 M_{\\odot}$ binary black holes merger. Despite the strong interest in the model, there is a lack of studies on possible cosmological implications and effects on cosmological parameters inference. We investigate correlations with the other standard cosmological parameters using cosmic microwave background observation...

  12. Primordial nucleosynthesis revisited via Trojan Horse Results

    Directory of Open Access Journals (Sweden)

    Pizzone R.G.

    2016-01-01

    Full Text Available Big Bang Nucleosynthesis (BBN requires several nuclear physics inputs and nuclear reaction rates. An up-to-date compilation of direct cross sections of d(d,pt, d(d,n3He and 3He(d,p4He reactions is given, being these ones among the most uncertain bare-nucleus cross sections. An intense experimental effort has been carried on in the last decade to apply the Trojan Horse Method (THM to study reactions of relevance for the BBN and measure their astrophysical S(E-factor. The reaction rates and the relative error for the four reactions of interest are then numerically calculated in the temperature ranges of relevance for BBN (0.01primordial nucleosynthesis calculations in order to evaluate their impact on the calculated primordial abundances of D, 3,4He and 7Li. These were compared with the observational primordial abundance estimates in different astrophysical sites. A comparison was also performed with calculations using other reaction rates compilations available in literature.

  13. Primordial nucleosynthesis revisited via Trojan Horse Results

    Science.gov (United States)

    Pizzone, R. G.; Spartá, R.; Bertulani, C.; Spitaleri, C.; La Cognata, M.; Lamia, L.; Mukhamedzhanov, A.; Tumino, A.

    2016-05-01

    Big Bang Nucleosynthesis (BBN) requires several nuclear physics inputs and nuclear reaction rates. An up-to-date compilation of direct cross sections of d(d,p)t, d(d,n)3He and 3He(d,p)4He reactions is given, being these ones among the most uncertain bare-nucleus cross sections. An intense experimental effort has been carried on in the last decade to apply the Trojan Horse Method (THM) to study reactions of relevance for the BBN and measure their astrophysical S(E)-factor. The reaction rates and the relative error for the four reactions of interest are then numerically calculated in the temperature ranges of relevance for BBN (0.01primordial nucleosynthesis calculations in order to evaluate their impact on the calculated primordial abundances of D, 3,4He and 7Li. These were compared with the observational primordial abundance estimates in different astrophysical sites. A comparison was also performed with calculations using other reaction rates compilations available in literature.

  14. THM and primordial nucleosynthesis: Results and perspectives

    Science.gov (United States)

    Pizzone, R. G.; Spartá, R.; Bertulani, C.; Spitaleri, C.; La Cognata, M.; Lamia, L.; Tumino, A.

    2017-09-01

    Big Bang Nucleosynthesis (BBN) requires several nuclear physics inputs and nuclear reaction rates. An up-to-date compilation of direct cross sections of d(d,p)t, d(d,n) 3 He and 3 He(d,p) 4 He reactions is given, being these ones among the most uncertain bare-nucleus cross sections. An intense experimental effort has been carried on in the last decade to apply the Trojan Horse Method (THM) to study reactions of relevance for the BBN and measure their astrophysical S( E) -factor. The reaction rates and the relative error for the four reactions of interest are then numerically calculated in the temperature ranges of relevance for BBN ( 0.01primordial nucleosynthesis calculations in order to evaluate their impact on the calculated primordial abundances of D, ^{3,4} He and ^7 Li. These were compared with the observational primordial abundance estimates in different astrophysical sites. Reactions to be studied in perspective will also be discussed.

  15. Suppression of Notch signaling in the neonatal mouse ovary decreases primordial follicle formation.

    Science.gov (United States)

    Trombly, Daniel J; Woodruff, Teresa K; Mayo, Kelly E

    2009-02-01

    Notch signaling directs cell fate during embryogenesis by influencing cell proliferation, differentiation, and apoptosis. Notch genes are expressed in the adult mouse ovary, and roles for Notch in regulating folliculogenesis are beginning to emerge from mouse genetic models. We investigated how Notch signaling might influence the formation of primordial follicles. Follicle assembly takes place when germ cell syncytia within the ovary break down and germ cells are encapsulated by pregranulosa cells. In the mouse, this occurs during the first 4-5 d of postnatal life. The expression of Notch family genes in the neonatal mouse ovary was determined through RT-PCR measurements. Jagged1, Notch2, and Hes1 transcripts were the most abundantly expressed ligand, receptor, and target gene, respectively. Jagged1 and Hey2 mRNAs were up-regulated over the period of follicle formation. Localization studies demonstrated that JAGGED1 is expressed in germ cells prior to follicle assembly and in the oocytes of primordial follicles. Pregranulosa cells that surround germ cell nests express HES1. In addition, pregranulosa cells of primordial follicles expressed NOTCH2 and Hey2 mRNA. We used an ex vivo ovary culture system to assess the requirement for Notch signaling during early follicle development. Newborn ovaries cultured in the presence of gamma-secretase inhibitors, compounds that attenuate Notch signaling, had a marked reduction in primordial follicles compared with vehicle-treated ovaries, and there was a corresponding increase in germ cells that remained within nests. These data support a functional role for Notch signaling in regulating primordial follicle formation.

  16. Primordial alignment of elliptical galaxies in intermediate redshift clusters

    CERN Document Server

    Rong, Yu; Liao, Jin-Yuan

    2015-01-01

    We measure primordial alignments for the red galaxies in the sample of eight massive galaxy clusters in the southern sky from the CLASH-VLT Large Programme, at a median redshift of 0.375. We find primordial alignment with about $3\\sigma$ significance in the four dynamically young clusters, but null detection of primordial alignment in the four highly relaxed clusters. The observed primordial alignment is not dominated by any single one of the four dynamically young clusters, and is primarily due to a population of bright galaxies ($M_r<-20.5\\ \\rm{m}$) residing in the region 300 to 810 kpc from the cluster centers. For the first time, we point out that the combination of radial alignment and halo alignment can cause fake primordial alignment. Finally, we find that the detected alignment for the dynamically young clusters is real rather than fake primordial alignment.

  17. Knockdown of FOXO3 induces primordial oocyte activation in pigs.

    Science.gov (United States)

    Moniruzzaman, Mohammad; Lee, Jibak; Zengyo, Mai; Miyano, Takashi

    2010-02-01

    Mammalian ovaries are endowed with a large number of primordial follicles, each containing a nongrowing oocyte. Only a small population of primordial oocytes (oocytes in primordial follicles) is activated to enter the growth phase throughout a female's reproductive life. Little is known about the mechanism regulating the activation of primordial oocytes. Here, we found that the primordial oocytes from infant pigs (10- to 20-day-old) grew to full size at 2 months after xenografting to immunodeficient mice, whereas those from prepubertal pigs (6-month-old) survived without initiation of their growth even after 4 months; thereafter, they started to grow and reached full size after 6 months. These results suggest that the mechanism regulating the activation of primordial oocytes in prepubertal pigs is different from that in infant pigs. In this regard, the involvement of FOXO3, a forkhead transcription factor, was studied. In prepubertal pigs, FOXO3 was detected in almost all (94+/-2%) primordial oocyte nuclei, and in infant pigs, 42+/-7% primordial oocytes were FOXO3 positive. At 4 months after xenografting, the percentage of FOXO3-positive primordial oocytes from prepubertal pigs had decreased to the infant level. Further, siRNA was designed to knock down porcine FOXO3. FOXO3-knockdown primordial follicles from prepubertal pigs developed to the antral stage accompanied by oocyte growth at 2 months after xenografting. These results suggest that primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.

  18. Relaxing the Bounds on Primordial Magnetic Seed Fields

    OpenAIRE

    1999-01-01

    We point out that the lower bound on the primordial magnetic field required to seed the galactic dynamo is significantly relaxed in an open universe or in a universe with a positive cosmological constant. It is shown that, for reasonable cosmological parameters, primordial seed fields of strength 10^{-30} Gauss or less at the time of galaxy formation could explain observed galactic magnetic fields. As a consequence, mechanisms of primordial magnetic seed-field generation that have previously ...

  19. Clusters of primordial black holes and reionization problem

    Energy Technology Data Exchange (ETDEWEB)

    Belotsky, K. M., E-mail: k-belotsky@yandex.ru; Kirillov, A. A., E-mail: kirillov-aa@yandex.ru; Rubin, S. G., E-mail: sergeirubin@list.ru [National Research Nuclear University MEPhI (Moscow Engineering Physics Institute) (Russian Federation)

    2015-05-15

    Clusters of primordial black holes may cause the formation of quasars in the early Universe. In turn, radiation from these quasars may lead to the reionization of the Universe. However, the evaporation of primordial black holes via Hawking’s mechanism may also contribute to the ionization of matter. The possibility of matter ionization via the evaporation of primordial black holes with allowance for existing constraints on their density is discussed. The contribution to ionization from the evaporation of primordial black holes characterized by their preset mass spectrum can roughly be estimated at about 10{sup −3}.

  20. Fingerprints of Primordial Universe Paradigms as Features in Density Perturbations

    CERN Document Server

    Chen, Xingang

    2011-01-01

    Experimentally distinguishing different primordial universe paradigms that lead to the Big Bang model is an outstanding challenge in modern cosmology and astrophysics. We show that a generic type of signals that exist in primordial universe models can be used for such purpose. These signals are induced by tiny oscillations of massive fields and manifest as features in primordial density perturbations. They are capable of recording the time-dependence of the scale factor of the primordial universe, and therefore provide direct evidence for specific paradigm.

  1. The primordial helium abundance from updated emissivities

    Energy Technology Data Exchange (ETDEWEB)

    Aver, Erik [Department of Physics, Gonzaga University, 502 E Boone Ave, Spokane, WA, 99258 (United States); Olive, Keith A.; Skillman, Evan D. [School of Physics and Astronomy, University of Minnesota, 116 Church St. SE, Minneapolis, MN, 55455 (United States); Porter, R.L., E-mail: aver@gonzaga.edu, E-mail: olive@umn.edu, E-mail: ryanlporter@gmail.com, E-mail: skillman@astro.umn.edu [Department of Physics and Astronomy, University of Georgia, Athens, GA, 30602 (United States)

    2013-11-01

    Observations of metal-poor extragalactic H II regions allow the determination of the primordial helium abundance, Y{sub p}. The He I emissivities are the foundation of the model of the H II region's emission. Porter, Ferland, Storey, and Detisch (2012) have recently published updated He I emissivities based on improved photoionization cross-sections. We incorporate these new atomic data and update our recent Markov Chain Monte Carlo analysis of the dataset published by Izotov, Thuan, and Stasi'nska (2007). As before, cuts are made to promote quality and reliability, and only solutions which fit the data within 95% confidence level are used to determine the primordial He abundance. The previously qualifying dataset is almost entirely retained and with strong concordance between the physical parameters. Overall, an upward bias from the new emissivities leads to a decrease in Y{sub p}. In addition, we find a general trend to larger uncertainties in individual objects (due to changes in the emissivities) and an increased variance (due to additional objects included). From a regression to zero metallicity, we determine Y{sub p} = 0.2465 ± 0.0097, in good agreement with the BBN result, Y{sub p} = 0.2485 ± 0.0002, based on the Planck determination of the baryon density. In the future, a better understanding of why a large fraction of spectra are not well fit by the model will be crucial to achieving an increase in the precision of the primordial helium abundance determination.

  2. Study of the primordial lithium abundance

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    Lithium isotopes have attracted an intense interest because the abundance of both 6Li and 6Li from big bang nucleosynthesis (BBN) is one of the puzzles in nuclear astrophysics. Many investigations of both astrophysical observation and nucleosynthesis calculation have been carried out to solve the puzzle, but it is not solved yet. Several nuclear reactions involving lithium have been indirectly measured at China Institute of Atomic Energy, Beijing. The Standard BBN (SBBN) network calculations are then performed to investigate the primordial Lithium abundance. The result shows that these nuclear reactions have minimal effect on the SBBN abundances of 6Li and 7Li.

  3. Primordial hadrosynthesis in the Little Bang

    CERN Document Server

    Heinz, Ulrich W

    1999-01-01

    The present status of soft hadron production in high energy heavy-ion collisions is summarized. In spite of strong evidence for extensive dynamical evolution and collective expansion of the fireball before freeze-out I argue that its chemical composition is hardly changed by hadronic final state interactions. The measured hadron yields thus reflect the primordial conditions at hadronization. The observed production pattern is consistent with statistical hadronization at the Hagedorn temperature from a state of uncorrelated, color deconfined quarks and antiquarks, but requires non-trivial chemical evolution of the fireball in a prehadronic (presumably QGP) stage before hadron formation.

  4. Astrophysical structures from primordial quantum black holes

    Energy Technology Data Exchange (ETDEWEB)

    Capozziello, Salvatore; Cristofano, Gerardo; Laurentis, Mariafelicia de [Universita di Napoli ' ' Federico II' ' , Dipartimento di Scienze Fisiche, Napoli (Italy); Compl. Univ. di Monte S. Angelo, INFN Sez. di Napoli, Napoli (Italy)

    2010-09-15

    The characteristic sizes of astrophysical structures, up to the whole observed Universe, can be recovered, in principle, assuming that gravity is the overall interaction assembling systems starting from microscopic scales, whose order of magnitude is ruled by the Planck length and the related Compton wavelength. This result agrees with the absence of screening mechanisms for the gravitational interaction and could be connected to the presence of Yukawa corrections in the Newtonian potential which introduce typical interaction lengths. This result directly comes out from quantization of primordial black holes and then characteristic interaction lengths directly emerge from quantum field theory. (orig.)

  5. Primordial fluctuations in extended Liouville theory

    Science.gov (United States)

    Moore, Wynton E.

    2015-03-01

    Liouville gravity can be used to precisely model features of 3+1 dimensional cosmology in a simplified 1+1d setting. We study primordial fluctuations in a generally covariant extension of Liouville theory, in the context of single field inflation. The scale invariant spectrum of scalar curvature perturbations is exhibited, and their three-point correlation function is computed in the slow roll approximation. We recover Maldacena's consistency relation for the three-point function, which in this context depends on a global shift symmetry of extended Liouville theory.

  6. Primordial fluctuations in extended Liouville theory

    CERN Document Server

    Moore, Wynton E

    2014-01-01

    Liouville gravity can be used to precisely model features of 3+1 dimensional cosmology in a simplified 1+1d setting. We study primordial fluctuations in a generally covariant extension of Liouville theory, in the context of single field inflation. The scale invariant spectrum of scalar curvature perturbations is exhibited, and their three-point correlation function is computed in the slow roll approximation. We recover Maldacena's consistency relation for the three-point function, which in this context depends on a global shift symmetry of extended Liouville theory.

  7. Inflation and dark matter primordial black holes

    Energy Technology Data Exchange (ETDEWEB)

    Erfani, Encieh

    2012-09-15

    In this thesis a broad range of single field models of inflation are analyzed in light of all relevant recent cosmological data, checking whether they can lead to the formation of long-lived Primordial Black Holes (PBHs) to serve as candidates for Dark Matter. To that end we calculate the spectral index of the power spectrum of primordial perturbations as well as its first and second derivatives. PBH formation is possible only if the spectral index increases significantly at small scales, i.e. large wave number k. Since current data indicate that the first derivative {alpha}{sub S} of the spectral index n{sub S}(k{sub pivot}) is negative at the pivot scale k{sub pivot}, PBH formation is only possible in the presence of a sizable and positive second derivative (''running of the running'') {beta}{sub S}. Among the three small-field and five large-field inflation models we analyze, only one small-field model, the ''running-mass'' model, allows PBH formation, for a narrow range of parameters. We also note that none of the models we analyze can accord for a large and negative value of {alpha}{sub S}, which is weakly preferred by current data. Similarly, proving conclusively that the second derivative of the spectral index is positive would exclude all the large-field models we investigated.

  8. Primordial Particles; Collisions of Inelastic Particles

    Science.gov (United States)

    Sagi, George

    2011-03-01

    Three-dimensional matter is not defined by Euclidian or Cartesian geometries. Newton's and Einstein's laws are related to the motions of elastic masses. The study of collisions of inelastic particles opens up new vistas in physics. The present article reveals how such particles create clusters composed of various numbers of particles. The Probability of each formation, duplets, triplets, etc. can be calculated. The particles are held together by a binding force, and depending upon the angles of collisions they may also rotate around their center of geometry. Because of these unique properties such inelastic particles are referred to as primordial particles, Pp. When a given density of Pp per cubic space is given, then random collisions create a field. The calculation of the properties of such primordial field is very complex and beyond the present study. However, the angles of collisions are infinite in principle, but the probabilities of various cluster sizes are quantum dependent. Consequently, field calculations will require new complex mathematical methods to be discovered yet.

  9. A natural origin of primordial density perturbations

    CERN Document Server

    Lieu, Richard

    2009-01-01

    We suggest here a mechanism for the seeding of the primordial density fluctuations. We point out that a process like reheating at the end of inflation will inevitably generate perturbations, even on superhorizon scales, by the local diffusion of energy. Provided that the reheating temperature is of order the GUT scale, the density contrast $\\delta_R$ for spheres of radius $R$ will be of order $10^{-5}$ at horizon entry, consistent with the values measured by \\texttt{WMAP}. If this were a purely classical process, $\\delta_R^2$ would fall as $1/R^4$ beyond the horizon, and the resulting primordial density power spectrum would be $P(k) \\propto k^n$ with $n=4$. However, as shown by Gabrielli et al, a quantum diffusion process can generate a power spectrum with any index in the range $01$). Thus, the two characteristic parameters that determine the appearance of present day structures could be natural consequences of this mechanism. These are in any case the minimum density variations that must have formed if the ...

  10. The H II Region of a Primordial Star

    Science.gov (United States)

    Abel, Tom; Wise, John H.; Bryan, Greg L.

    2007-04-01

    The concordance model of cosmology and structure formation predicts the formation of isolated, very massive stars at high redshifts in dark matter-dominated halos of 105-106 Msolar. These stars photoionize their host primordial molecular clouds, expelling all the baryons from their halos. When the stars die, a relic H II region is formed within which large amounts of molecular hydrogen form that will allow the gas to cool efficiently when gravity assembles it into larger dark matter halos. The filaments surrounding the first star-hosting halo are largely shielded and provide the pathway for gas to stream into the halo when the star has died. We present the first fully three-dimensional cosmological radiation hydrodynamical simulations that follow all these effects. A novel adaptive ray-casting technique incorporates the time-dependent radiative transfer around point sources. This approach is fast enough so that radiation transport, kinetic rate equations, and hydrodynamics are solved self-consistently. It retains the time derivative of the transfer equation and is explicitly photon-conserving. This method is integrated with the cosmological adaptive mesh refinement code Enzo and runs on distributed and shared memory parallel architectures. Where applicable, the three-dimensional calculation not only confirms expectations from earlier one-dimensional results but also illustrates the multifold hydrodynamic complexities of H II regions. In the absence of stellar winds, the circumstellar environments of the first supernovae and putative early gamma-ray bursts will be of low density, ~1 cm-3. Albeit marginally resolved, ionization front instabilities lead to cometary- and elephant trunk-like small-scale structures reminiscent of nearby star-forming regions.

  11. Sex Specification and Heterogeneity of Primordial Germ Cells in Mice.

    Science.gov (United States)

    Sakashita, Akihiko; Kawabata, Yukiko; Jincho, Yuko; Tajima, Shiun; Kumamoto, Soichiro; Kobayashi, Hisato; Matsui, Yasuhisa; Kono, Tomohiro

    2015-01-01

    In mice, primordial germ cells migrate into the genital ridges by embryonic day 13.5 (E13.5), where they are then subjected to a sex-specific fate with female and male primordial germ cells undergoing mitotic arrest and meiosis, respectively. However, the sex-specific basis of primordial germ cell differentiation is poorly understood. The aim of this study was to investigate the sex-specific features of mouse primordial germ cells. We performed RNA-sequencing (seq) of E13.5 female and male mouse primordial germ cells using next-generation sequencing. We identified 651 and 428 differentially expressed transcripts (>2-fold, P primordial germ cells, respectively. Of these, many transcription factors were identified. Gene ontology and network analysis revealed differing functions of the identified female- and male-specific genes that were associated with primordial germ cell acquisition of sex-specific properties required for differentiation into germ cells. Furthermore, DNA methylation and ChIP-seq analysis of histone modifications showed that hypomethylated gene promoter regions were bound with H3K4me3 and H3K27me3. Our global transcriptome data showed that in mice, primordial germ cells are decisively assigned to a sex-specific differentiation program by E13.5, which is necessary for the development of vital germ cells.

  12. Primordial non-Gaussianity from the large scale structure

    CERN Document Server

    Desjacques, Vincent

    2010-01-01

    Primordial non-Gaussianity is a potentially powerful discriminant of the physical mechanisms that generated the cosmological fluctuations observed today. Any detection of non-Gaussianity would have profound implications for our understanding of cosmic structure formation. In this paper, we review past and current efforts in the search for primordial non-Gaussianity in the large scale structure of the Universe.

  13. Variable speed of light cosmology, primordial fluctuations and gravitational waves

    Energy Technology Data Exchange (ETDEWEB)

    Moffat, J.W. [Perimeter Institute for Theoretical Physics, Waterloo, Ontario (Canada); University of Waterloo, Department of Physics and Astronomy, Waterloo, Ontario (Canada)

    2016-03-15

    A variable speed of light (VSL) cosmology is described in which the causal mechanism of generating primordial perturbations is achieved by varying the speed of light in a primordial epoch. This yields an alternative to inflation for explaining the formation of the cosmic microwave background (CMB) and the large scale structure (LSS) of the universe. The initial value horizon and flatness problems in cosmology are solved. The model predicts primordial scalar and tensor fluctuation spectral indices n{sub s} = 0.96 and n{sub t} = - 0.04, respectively. We make use of the δN formalism to identify signatures of primordial nonlinear fluctuations, and this allows the VSL model to be distinguished from inflationary models. In particular, we find that the parameter f{sub NL} = 5 in the variable speed of light cosmology. The value of the parameter g{sub NL} evolves during the primordial era and shows a running behavior. (orig.)

  14. Baryon asymmetry from primordial black holes

    CERN Document Server

    Hamada, Yuta

    2016-01-01

    We propose a new scenario of the baryogenesis from primordial black holes (PBH). Assuming presence of a microscopic baryon (or lepton) number violation and a CP violating operator such as $\\partial_\\alpha F(\\mathcal{R_{....}} ) J^\\alpha$ where $F(\\mathcal{R_{....}})$ is a scalar function of the Riemann tensor, time evolution of an evaporating black hole generates baryonic (leptonic) chemical potential at the horizon; consequently PBH enumerates asymmetric Hawking radiation between baryons (leptons) and anti-baryons (leptons). Though the operator is higher dimensional and largely suppressed by a high mass scale $M_*$, we show that sufficient amount of asymmetry can be generated for wide range of parameters of the PBH mass $M_{\\rm PBH}$, its abundance $\\Omega_{\\rm PBH}$, and the scale $M_*$.

  15. An Update of the Primordial Helium Abundance

    Science.gov (United States)

    Peimbert, Antonio; Peimbert, Manuel; Luridiana, Valentina

    2015-08-01

    Three of the best determinations of the primordial helium abundance (Yp) are those obtained from low metallicity HII regions by Aver, Olive, Porter, & Skillman (2013); Izotov, Thuan, & Guseva (2014); and Peimbert, Peimbert, & Luridiana (2007). In this poster we update the Yp determination by Peimbert et al. taking into account, among other aspects, recent advances in the determination of the He atomic physical parameters, the temperature structure, the collisional effects of high temperatures on the Balmer lines, as well as the effect of H and He bound-bound absorption.We compare our results with those of Aver et al. and Izotov et al. and point out possible explanations for the differences among the three determinations. We also compare our results with those obtained with the Plank satellite considering recent measurements of the neutron mean life; this comparison has implications on the determination of the number of light neutrino families.

  16. Entanglement time in the primordial universe

    CERN Document Server

    Bianchi, Eugenio; Yokomizo, Nelson

    2015-01-01

    We investigate the behavior of the entanglement entropy of space in the primordial phase of the universe before the beginning of cosmic inflation. We argue that in this phase the entanglement entropy of a region of space grows from a zero-law to an area-law. This behavior provides a quantum version of the classical BKL conjecture that spatially separated points decouple in the approach to a cosmological singularity. We show that the relational growth of the entanglement entropy with the scale factor provides a new statistical notion of arrow of time in quantum gravity. The growth of entanglement in the pre-inflationary phase provides a mechanism for the production of the quantum correlations present at the beginning of inflation and imprinted in the CMB sky.

  17. Primordial beryllium as a big bang calorimeter.

    Science.gov (United States)

    Pospelov, Maxim; Pradler, Josef

    2011-03-25

    Many models of new physics including variants of supersymmetry predict metastable long-lived particles that can decay during or after primordial nucleosynthesis, releasing significant amounts of nonthermal energy. The hadronic energy injection in these decays leads to the formation of ⁹Be via the chain of nonequilibrium transformations: Energy(h)→T, ³He→⁶He, ⁶Li→⁹Be. We calculate the efficiency of this transformation and show that if the injection happens at cosmic times of a few hours the release of O(10 MeV) per baryon can be sufficient for obtaining a sizable ⁹Be abundance. The absence of a plateau structure in the ⁹Be/H abundance down to a O(10⁻¹⁴) level allows one to use beryllium as a robust constraint on new physics models with decaying or annihilating particles.

  18. The HII Region of a Primordial Star

    CERN Document Server

    Abel, T; Bryan, G L; Abel, Tom; Wise, John H.; Bryan, Greg L.

    2006-01-01

    The concordance model of cosmology and structure formation predicts the formation of isolated very massive stars at high redshifts in dark matter dominated halos of 10^5 to 10^6 Msun. These stars photo-ionize their host primordial molecular clouds, expelling all the baryons from their halos. When the stars die, a relic HII region is formed within which large amounts of molecular hydrogen form which will allow the gas to cool efficiently when gravity assembles it into larger dark matter halos. The filaments surrounding the first star hosting halo are largely shielded and provide the pathway for gas to stream into the halo when the star has died. We present the first fully three dimensional cosmological radiation hydrodynamical simulations that follow all these effects. A novel adaptive ray casting technique incorporates the time dependent radiative transfer around point sources. This approach is fast enough so that radiation transport, kinetic rate equations, and hydrodynamics are solved self-consistently. It ...

  19. The Primordial Inflation Polarization Explorer (PIPER)

    Science.gov (United States)

    Gandilo, Natalie; Ade, Peter; Benford, Dominic J.; Bennett, Charles L.; Chuss, David T.; Dotson, Jessie L.; Eimer, Joseph; Fixsen, Dale J.; Halpern, Mark; Hilton, Gene; Hinshaw, Gary F.; Irwin, Kent; Jhabvala, Christine; Kimball, Mark; Kogut, Alan J.; Lowe, Luke; McMahon, Jeff; Miller, Timothy; Mirel, Paul; Moseley, Samuel H.; Pawlyk, Samuel; Rodriguez, Samelys; Sharp, Elmer; Shirron, Peter; Staguhn, Johannes; Sullivan, Dan; Switzer, Eric; Taraschi, Peter; tucker, carole; Wollack, Edward

    2017-01-01

    We present an overview of PIPER, the Primordial Inflation Polarization Explorer. PIPER is a balloon-borne telescope designed to map the large scale polarization of the Cosmic Microwave Background as well as the polarized emission from galactic dust at 200, 270, 350, and 600 GHz, with 21, 15, 14, and 14 arcminutes of angular resolution respectively. PIPER uses twin telescopes with Variable-delay Polarization Modulators to simultaneously map Stokes I, Q, U and V. Cold optics and the lack of a warm window allow the instrument to achieve background limited sensitivity. Over the course of 8 conventional balloon flights from the Northern and Southern hemisphere, PIPER will map 85% of the sky, measuring the B-mode polarization spectrum from the reionization bump to l~300, and placing an upper limit on the tensor-to-scalar ratio of rPIPER's first science flight will be in June 2017 from Palestine, Texas.

  20. Primordial Gravitational Waves in Bimetric Gravity

    CERN Document Server

    Sakakihara, Yuki

    2015-01-01

    We study primordial tensor power-spectra generated during inflation in bimetric gravity. More precisely, we examine a homogeneous expanding spacetime in a minimal bimetric model with an inflaton and calculate tensor perturbations on the homogeneous background under slow-roll approximation. In terms of the mass eigenstates, only the power-spectrum of the massless state remains constant and both the power-spectrum of the massive state and the cross power-spectrum rapidly decay during inflation. The amplitude of the physical power-spectrum is suppressed due to the flavor mixing. All power-spectra in the flavor eigenstates coincide with each other up to the first order of the slow-roll parameter.

  1. The Search for Primordial Molecular Cloud Matter

    DEFF Research Database (Denmark)

    van Kooten, Elishevah M M E

    Our Solar System today presents a somewhat static picture compared to the turbulent start of its existence. Meteorites are the left-over building blocks of planet formation and allow us to probe the chemical and physical processes that occurred during the first few million years of Solar System...... evolution. Some of the least altered, most primitive meteorites can give us clues to the original make-up of the interstellar molecular cloud from which the Sun and its surrounding planets formed, thus, permitting us to trace Solar System formation from its most early conditions. Using state......-of-the-art magnesium and chromium isotope techniques, we can distinguish a class of metal-rich meteorites with primordial molecular cloud signatures that show these objects formed in accretion regions akin to comets. As comets are proposed to have delivered some of the prerequisites of life to Earth, for example...

  2. The origin of life from primordial planets

    Science.gov (United States)

    Gibson, Carl H.; Schild, Rudolph E.; Wickramasinghe, N. Chandra

    2011-04-01

    The origin of life and the origin of the Universe are among the most important problems of science and they might be inextricably linked. Hydro-gravitational-dynamics cosmology predicts hydrogen-helium gas planets in clumps as the dark matter of galaxies, with millions of planets per star. This unexpected prediction is supported by quasar microlensing of a galaxy and a flood of new data from space telescopes. Supernovae from stellar over-accretion of planets produce the chemicals (C, N, O, P, etc.) and abundant liquid-water domains required for first life and the means for wide scattering of life prototypes. Life originated following the plasma-to-gas transition between 2 and 20 Myr after the big bang, while planetary core oceans were between critical and freezing temperatures, and interchanges of material between planets constituted essentially a cosmological primordial soup. Images from optical, radio and infrared space telescopes suggest life on Earth was neither first nor inevitable.

  3. Primordial Evolution in the Finitary Process Soup

    Science.gov (United States)

    Görnerup, Olof; Crutchfield, James P.

    A general and basic model of primordial evolution—a soup of reacting finitary and discrete processes—is employed to identify and analyze fundamental mechanisms that generate and maintain complex structures in prebiotic systems. The processes—ɛ-machines as defined in computational mechanics—and their interaction networks both provide well defined notions of structure. This enables us to quantitatively demonstrate hierarchical self-organization in the soup in terms of complexity. We found that replicating processes evolve the strategy of successively building higher levels of organization by autocatalysis. Moreover, this is facilitated by local components that have low structural complexity, but high generality. In effect, the finitary process soup spontaneously evolves a selection pressure that favors such components. In light of the finitary process soup's generality, these results suggest a fundamental law of hierarchical systems: global complexity requires local simplicity.

  4. The Origin of Life from Primordial Planets

    CERN Document Server

    Gibson, Carl H; Wickramasinghe, N C

    2010-01-01

    The origin of life and the origin of the universe represent two of the most important problems of science. Both are resolved by hydro-gravitational dynamics (HGD) cosmology (Gibson 1996, Schild 1996, Gibson 2009ab), which predicts frozen primordial hydrogen-helium gas planets in clumps as the dark matter of galaxies. Merging Earth-mass planets formed stars, moons and comets to incubate and cosmically seed the first life. Cometary panspermia (Hoyle and Wickramasinghe 1981, 1982; Wickramasinghe et al. 2009) occurs naturally by HGD mechanisms. Comets and moons are fragments from mergers of stardust covered frozen gas planets in their step-wise growth to star mass. Supernovae from stellar over-accretion of planets produce stardust (C, N, O, P etc.) chemical fertilizer. Planets collect this infected radioactive dust gravitationally, to provide liquid water domains in contact with life nutrients seeded with life prototypes. The first mutating, evolving, life from HGD likely occurred promptly, following the plasma t...

  5. PAPPA: Primordial Anisotropy Polarization Pathfinder Array

    CERN Document Server

    Kogut, A; Fixsen, D; Hinshaw, G F; Limon, M; Moseley, S H; Phillips, N; Sharp, E; Wollack, E J; U-Yen, K; Cao, N; Stevenson, T; Hsieh, W; Devlin, M; Dicker, S; Semisch, C; Irwin, K

    2006-01-01

    The Primordial Anisotropy Polarization Pathfinder Array (PAPPA) is a balloon-based instrument to measure the polarization of the cosmic microwave background and search for the signal from gravity waves excited during an inflationary epoch in the early universe. PAPPA will survey a 20 x 20 deg patch at the North Celestial Pole using 32 pixels in 3 passbands centered at 89, 212, and 302 GHz. Each pixel uses MEMS switches in a superconducting microstrip transmission line to combine the phase modulation techniques used in radio astronomy with the sensitivity of transition-edge superconducting bolometers. Each switched circuit modulates the incident polarization on a single detector, allowing nearly instantaneous characterization of the Stokes I, Q, and U parameters. We describe the instrument design and status.

  6. Hydrodynamics of primordial black hole formation

    Science.gov (United States)

    Nadezhin, D. K.; Novikov, I. D.; Polnarev, A. G.

    1979-01-01

    The hydrodynamic picture of the formation of primordial black holes (PBH) at the early stages of expansion of the Universe is considered. It is assumed that close to singularity, expansion occurs in a quasi-isotropic way. Using an EVM, a spherically symmetrical nonlinear problem of the evolution of primary strong deviation from the Fridman solution was solved. What these deviations must be, so that the formation of PBH occurred was clarified. Attention was devoted to the role of pressure gradients. It is pointed out that at the moment of formation of PBH, only a small part of matter enters into it, primarily the component of perturbation. It is also pointed out that at this moment, the mass of PBH essentially is smaller than the mass considered within the cosmic horizon. The possibility of changing the mass of the PBH as a result of accretion is analyzed.

  7. Genomic analysis of primordial dwarfism reveals novel disease genes.

    Science.gov (United States)

    Shaheen, Ranad; Faqeih, Eissa; Ansari, Shinu; Abdel-Salam, Ghada; Al-Hassnan, Zuhair N; Al-Shidi, Tarfa; Alomar, Rana; Sogaty, Sameera; Alkuraya, Fowzan S

    2014-02-01

    Primordial dwarfism (PD) is a disease in which severely impaired fetal growth persists throughout postnatal development and results in stunted adult size. The condition is highly heterogeneous clinically, but the use of certain phenotypic aspects such as head circumference and facial appearance has proven helpful in defining clinical subgroups. In this study, we present the results of clinical and genomic characterization of 16 new patients in whom a broad definition of PD was used (e.g., 3M syndrome was included). We report a novel PD syndrome with distinct facies in two unrelated patients, each with a different homozygous truncating mutation in CRIPT. Our analysis also reveals, in addition to mutations in known PD disease genes, the first instance of biallelic truncating BRCA2 mutation causing PD with normal bone marrow analysis. In addition, we have identified a novel locus for Seckel syndrome based on a consanguineous multiplex family and identified a homozygous truncating mutation in DNA2 as the likely cause. An additional novel PD disease candidate gene XRCC4 was identified by autozygome/exome analysis, and the knockout mouse phenotype is highly compatible with PD. Thus, we add a number of novel genes to the growing list of PD-linked genes, including one which we show to be linked to a novel PD syndrome with a distinct facial appearance. PD is extremely heterogeneous genetically and clinically, and genomic tools are often required to reach a molecular diagnosis.

  8. The Primordial Abundance of 4He Revisited

    Science.gov (United States)

    Izotov, Yuri I.; Thuan, Trinh X.

    1998-06-01

    We use a sample of 45 low-metallicity H II regions to determine the primordial helium abundance Yp with a precision of better than 1%. The data includes new spectrophotometric observations of 15 blue compact galaxies (BCGs) with oxygen abundance 12 + log (O/H) between 7.83 and 8.35 (Z⊙/13 Lipovetsky, but higher than previous determinations (Yp = 0.230-0.234). Part of the difference comes from the fact that previous investigators have used the northwest component of I Zw 18 in the determination of Yp. This component is subject to strong underlying He I stellar absorption that reduces the He I line intensities by 5%-25%. The derived Y is 0.233 +/- 0.008 from the He I λ6678 line. Instead, by using the southeast component of I Zw 18, which is much less subject to underlying He I stellar absorption, we obtain Y = 0.242 +/- 0.009. The mean Y of the two most metal-deficient BCGs, I Zw 18 and SBS 0335-052, is Ȳ=0.245+/-0.004, in excellent agreement with the Yp derived from the linear regressions. We derive a slope dY/dZ = 2.3 +/- 1.0, considerably smaller than those derived before. With this smaller slope and taking into account the errors, chemical evolution models with an outflow of well-mixed material can be built for star-forming dwarf galaxies that satisfy all the observational constraints. Our Yp gives Ωbh250=0.058+/-0.007, consistent with the lower limit set by dynamical measurements and X-ray observations of clusters of galaxies. It is also consistent, within the framework of standard big bang nucleosynthesis theory, with measurements of primordial 7Li in galactic halo stars, and at the 1 σ level with the D/H abundance measured in absorption systems toward quasars by Tytler & Burles.

  9. Dormancy and activation of human oocytes from primordial and primary follicles: molecular clues to oocyte regulation.

    Science.gov (United States)

    Ernst, E H; Grøndahl, M L; Grund, S; Hardy, K; Heuck, A; Sunde, L; Franks, S; Andersen, C Y; Villesen, P; Lykke-Hartmann, K

    2017-08-01

    Do specific transcriptome dynamics in human oocytes from primordial and primary follicles identify novel pathways in oocyte activation? The transcriptomic profiles in oocytes from primordial and primary follicles, respectively, revealed several new canonical pathways as putative mediators of oocyte dormancy and activation. Cellular signaling pathways including PI3K/AKT and AKT/mTOR as well as TGF-β and IGF signaling are known to regulate the primordial-to-primary transition in mammalian follicle development. We performed a class comparison study on human oocytes from primordial (n = 436) and primary (n = 182) follicles donated by three women having ovarian tissue cryopreserved before chemotherapy. RNA was extracted from oocytes from primordial and primary follicles isolated by Laser Capture Microdissection, and submitted to the HiSeq Illumina platform. Data mapping, quality control, filtering and expression analysis were performed using Tophat (2.0.4), Cufflinks (2.0.2), BWA (0.6.2) and software R. Modeling of complex biological systems was performed using the IPA® software. Finally, qPCR and immunohistochemistry were employed to explore expression and localization of selected genes and products in human ovarian tissue. We found 223 and 268 genes down-regulated and up-regulated, respectively, in the oocytes during the human primordial-to-primary follicle transition (P 2). IPA® enrichment analysis revealed known pathways ('mTOR Signaling', 'PI3K/AKT Signaling' and 'PTEN Signaling') as well as enriched canonical pathways not previously associated with human ovarian follicle development such as 'ErB Signaling' and 'NGF Signaling' in the down-regulated category and 'Regulation of eIF4 and P70S6K Signaling' and 'HER-2 Signaling in Breast Cancer' in the up-regulated group. Additionally, immunohistochemistry on human ovarian tissue explored the intraovarian localization of VASA, FOXO1 and eIF4E. http://users-birc.au.dk/biopv/published_data/ernst_2017/. This is a

  10. Putative Risk Factors in Developmental Dyslexia: A Case-Control Study of Italian Children

    Science.gov (United States)

    Mascheretti, Sara; Marino, Cecilia; Simone, Daniela; Quadrelli, Ermanno; Riva, Valentina; Cellino, Maria Rosaria; Maziade, Michel; Brombin, Chiara; Battaglia, Marco

    2015-01-01

    Although dyslexia runs in families, several putative risk factors that cannot be immediately identified as genetic predict reading disability. Published studies analyzed one or a few risk factors at a time, with relatively inconsistent results. To assess the contribution of several putative risk factors to the development of dyslexia, we conducted…

  11. Putative Risk Factors in Developmental Dyslexia: A Case-Control Study of Italian Children

    Science.gov (United States)

    Mascheretti, Sara; Marino, Cecilia; Simone, Daniela; Quadrelli, Ermanno; Riva, Valentina; Cellino, Maria Rosaria; Maziade, Michel; Brombin, Chiara; Battaglia, Marco

    2015-01-01

    Although dyslexia runs in families, several putative risk factors that cannot be immediately identified as genetic predict reading disability. Published studies analyzed one or a few risk factors at a time, with relatively inconsistent results. To assess the contribution of several putative risk factors to the development of dyslexia, we conducted…

  12. Evolution of Primordial Black Holes in Loop Quantum Cosmology

    Indian Academy of Sciences (India)

    D. Dwivedee; B. Nayak; M. Jamil; L. P. Singh; R. Myrzakulov

    2014-03-01

    In this work, we study the evolution of primordial black holes within the context of loop quantum cosmology. First we calculate the scale factor and energy density of the Universe for different cosmic era and then taking these as inputs, we study evolution of primordial black holes. From our estimation it is found that accretion of radiation does not affect evolution of primordial black holes in loop quantum cosmology. We also conclude that due to slow variation of scale factor, the upper bound on initial mass fraction of presently evaporating PBHs are much greater in loop quantum cosmology than the standard case.

  13. Primordial Gravitational Waves Induced by Magnetic Fields in Ekpyrotic Scenario

    CERN Document Server

    Ito, Asuka

    2016-01-01

    Both inflationary and ekpyrotic scenarios can account for the origin of the large scale structure of the universe. It is often said that detecting primordial gravitational waves is the key to distinguish both scenarios. We show that this is not true if the gauge kinetic function is present in the ekpyrotic scenario. In fact, primordial gravitational waves sourced by the gauge field can be produced in an ekpyrotic universe. We also study scalar fluctuations sourced by the gauge field and show that it is negligible compared to primordial gravitational waves. This comes from the fact that the fast roll condition holds in ekpyrotic models.

  14. Grand unification scale primordial black holes: consequences and constraints.

    Science.gov (United States)

    Anantua, Richard; Easther, Richard; Giblin, John T

    2009-09-11

    A population of very light primordial black holes which evaporate before nucleosynthesis begins is unconstrained unless the decaying black holes leave stable relics. We show that gravitons Hawking radiated from these black holes would source a substantial stochastic background of high frequency gravititational waves (10(12) Hz or more) in the present Universe. These black holes may lead to a transient period of matter-dominated expansion. In this case the primordial Universe could be temporarily dominated by large clusters of "Hawking stars" and the resulting gravitational wave spectrum is independent of the initial number density of primordial black holes.

  15. The Effect of Curvaton Decay on the Primordial Power Spectrum

    CERN Document Server

    Firouzjahi, Hassan; Malik, Karim; Zarei, Moslem

    2012-01-01

    We study the effect of curvaton decay on the primordial power spectrum. Using analytical approximations and also numerical calculations, we find that the power spectrum is enhanced during the radiation dominated era after the curvaton decay. The amplitude of the Bardeen potential is controlled by the fraction of the energy density in the curvaton at the time of curvaton decay. We show that the enhancement in the amplitude of the primordial curvature perturbation is, however, not large enough to lead to primordial black hole overproduction on scales which re-enter the horizon after the time of curvaton decay.

  16. Standard Clock in Primordial Density Perturbations and Cosmic Microwave Background

    CERN Document Server

    Chen, Xingang

    2014-01-01

    Standard Clocks in the primordial epoch leave a special type of features in the primordial perturbations, which can be used to directly measure the scale factor of the primordial universe as a function of time a(t), thus discriminating between inflation and alternatives. We have started to search for such signals in the Planck 2013 data using the key predictions of the Standard Clock. In this Letter, we present an interesting candidate with the inflation fingerprint. Motivated by this candidate, we construct and compute full Standard Clock models and use the more complete prediction to make more extensive comparison with data.

  17. Mutations in the NHEJ component XRCC4 cause primordial dwarfism.

    Science.gov (United States)

    Murray, Jennie E; van der Burg, Mirjam; IJspeert, Hanna; Carroll, Paula; Wu, Qian; Ochi, Takashi; Leitch, Andrea; Miller, Edward S; Kysela, Boris; Jawad, Alireza; Bottani, Armand; Brancati, Francesco; Cappa, Marco; Cormier-Daire, Valerie; Deshpande, Charu; Faqeih, Eissa A; Graham, Gail E; Ranza, Emmanuelle; Blundell, Tom L; Jackson, Andrew P; Stewart, Grant S; Bicknell, Louise S

    2015-03-05

    Non-homologous end joining (NHEJ) is a key cellular process ensuring genome integrity. Mutations in several components of the NHEJ pathway have been identified, often associated with severe combined immunodeficiency (SCID), consistent with the requirement for NHEJ during V(D)J recombination to ensure diversity of the adaptive immune system. In contrast, we have recently found that biallelic mutations in LIG4 are a common cause of microcephalic primordial dwarfism (MPD), a phenotype characterized by prenatal-onset extreme global growth failure. Here we provide definitive molecular genetic evidence supported by biochemical, cellular, and immunological data for mutations in XRCC4, encoding the obligate binding partner of LIG4, causing MPD. We report the identification of biallelic mutations in XRCC4 in five families. Biochemical and cellular studies demonstrate that these alterations substantially decrease XRCC4 protein levels leading to reduced cellular ligase IV activity. Consequently, NHEJ-dependent repair of ionizing-radiation-induced DNA double-strand breaks is compromised in XRCC4 cells. Similarly, immunoglobulin junctional diversification is impaired in cells. However, immunoglobulin levels are normal, and individuals lack overt signs of immunodeficiency. Additionally, in contrast to individuals with LIG4 mutations, pancytopenia leading to bone marrow failure has not been observed. Hence, alterations that alter different NHEJ proteins give rise to a phenotypic spectrum, from SCID to extreme growth failure, with deficiencies in certain key components of this repair pathway predominantly exhibiting growth deficits, reflecting differential developmental requirements for NHEJ proteins to support growth and immune maturation. Copyright © 2015 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.

  18. An unusual association of microcephalic osteodysplastic primordial dwarfism type I with cardiac and brain anomalies.

    Science.gov (United States)

    Bhutia, Euden; Verma, Arushi; Gupta, Amit Kumar; Maria, Arti

    2014-01-01

    Less than 100 cases of primordial dwarfism have been reported worldwide out of which Microcephalic osteodysplastic primordial dwarfism type I comprise about primordial dwarfism of antenatal onset due to Microcephalic osteodysplastic primordial dwarfism type I. Our case is also unique in being associated with hitertho unreported association of subpulmonic ventricular septal defect and a dorsal interhemispheric cyst in the brain.

  19. Genetics

    DEFF Research Database (Denmark)

    Christensen, Kaare; McGue, Matt

    2016-01-01

    The sequenced genomes of individuals aged ≥80 years, who were highly educated, self-referred volunteers and with no self-reported chronic diseases were compared to young controls. In these data, healthy ageing is a distinct phenotype from exceptional longevity and genetic factors that protect...

  20. PRISM: Recovery of the primordial spectrum from Planck data

    National Research Council Canada - National Science Library

    Lanusse, François; Paykari, P; Starck, J.-L; Sureau, F; Bobin, J; Rassat, A

    2014-01-01

    .... It provides an indirect probe of inflation or other structure-formation mechanisms. In this Letter, we recover the primordial power spectrum from the Planck PR1 dataset, using our recently published algorithm PRISM. Methods...

  1. Stochastic isocurvature baryon fluctuations, baryon diffusion, and primordial nucleosynthesis

    CERN Document Server

    Kurki-Suonio, H; Mathews, G J; Kurki-Suonio, Hannu; Jedamzik, Karsten; Mathews, Grant J

    1996-01-01

    We examine effects on primordial nucleosynthesis from a truly random spatial distribution in the baryon-to-photon ratio (\\eta). We generate stochastic fluctuation spectra characterized by different spectral indices and root-mean-square fluctuation amplitudes. For the first time we explicitly calculate the effects of baryon diffusion on the nucleosynthesis yields of such stochastic fluctuations. We also consider the collapse instability of large-mass-scale inhomogeneities. Our results are generally applicable to any primordial mechanism producing fluctuations in \\eta which can be characterized by a spectral index. In particular, these results apply to primordial isocurvature baryon fluctuation (PIB) models. The amplitudes of scale-invariant baryon fluctuations are found to be severely constrained by primordial nucleosynthesis. However, when the \\eta distribution is characterized by decreasing fluctuation amplitudes with increasing length scale, surprisingly large fluctuation amplitudes on the baryon diffusion ...

  2. Vector field instability and the primordial tensor spectrum

    CERN Document Server

    Eccles, Stefan; Lorshbough, Dustin; Stephens, Benjamin A

    2015-01-01

    It has recently been shown that the presence of a spectator pseudoscalar field, coupled to photons through a Chern-Simons term, can amplify the primordial tensor spectrum without observationally disrupting the primordial scalar spectrum. The amplification occurs due to an instability that develops for the vector fields. We extend previous studies to account for the contribution arising from an inhomogeneous vector background, which emerges as the dominant correction to the primordial tensor spectrum. These semiclassical contributions dominate over the quantum loop contributions and possibly enhance the primordial tensor spectrum such as to have observational effects even though the loop corrections might be undetectable. A similar effect would occur by replacing the visible electromagnetic U(1) by an unbroken dark U(1).

  3. Gene bionetworks that regulate ovarian primordial follicle assembly.

    Science.gov (United States)

    Nilsson, Eric; Zhang, Bin; Skinner, Michael K

    2013-07-23

    Primordial follicle assembly is the process by which ovarian primordial follicles are formed. During follicle assembly oocyte nests break down and a layer of pre-granulosa cells surrounds individual oocytes to form primordial follicles. The pool of primordial follicles formed is the source of oocytes for ovulation during a female's reproductive life. The current study utilized a systems approach to detect all genes that are differentially expressed in response to seven different growth factor and hormone treatments known to influence (increase or decrease) primordial follicle assembly in a neonatal rat ovary culture system. One novel factor, basic fibroblast growth factor (FGF2), was experimentally determined to inhibit follicle assembly. The different growth factor and hormone treatments were all found to affect similar physiological pathways, but each treatment affected a unique set of differentially expressed genes (signature gene set). A gene bionetwork analysis identified gene modules of coordinately expressed interconnected genes and it was found that different gene modules appear to accomplish distinct tasks during primordial follicle assembly. Predictions of physiological pathways important to follicle assembly were validated using ovary culture experiments in which ERK1/2 (MAPK1) activity was increased. A number of the highly interconnected genes in these gene networks have previously been linked to primary ovarian insufficiency (POI) and polycystic ovarian disease syndrome (PCOS). Observations have identified novel factors and gene networks that regulate primordial follicle assembly. This systems biology approach has helped elucidate the molecular control of primordial follicle assembly and provided potential therapeutic targets for the treatment of ovarian disease.

  4. Planck 2013 Results. XXIV. Constraints on primordial non-Gaussianity

    DEFF Research Database (Denmark)

    Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.

    2013-01-01

    The Planck nominal mission cosmic microwave background (CMB) maps yield unprecedented constraints on primordial non-Gaussianity (NG).Using three optimal bispectrum estimators, separable template-fitting (KSW), binned, and modal, we obtain consistent values for the primordiallocal, equilateral...... and Minkowski functional estimators. Beyond estimates of individual shapeamplitudes, we present model-independent, three-dimensional reconstructions of the Planck CMB bispectrum and thus derive constraints onearly-Universe scenarios that generate primordial NG, including general single-field models of inflation...

  5. Anisotropies of the infrared background and primordial galaxies

    Science.gov (United States)

    Cooray, Asantha R.

    2007-08-01

    We discuss anisotropies in the near-IR background between 1 to a few microns. This background is expected to contain a signature of primordial galaxies. We have measured fluctuations of resolved galaxies with Spitzer imaging data and we are developing a rocket-borne instrument (the Cosmic Infrared Background ExpeRiment, or CIBER) to search for signatures of primordial galaxy formation in the cosmic near-infrared extra-galactic background.

  6. Feasibility of Seeding Primordial Perturbations in a Decelerated Expanding Universe

    CERN Document Server

    Piao, Y S

    2006-01-01

    The scalar field with the modified dispersion relation under certain conditions may seed the primordial perturbations during a decelerated expansion. In this note we examine whether and how these perturbations can be responsible for the structure formation of observable universe. We find that there seems slightly difficult in matching the requirements of observable cosmology, i.e. obtain simultaneously the scale invariant spectrum of primordial perturbations and enough "efolding number", in a simple case. We discuss possible solutions to this problem.

  7. Gene Bionetwork Analysis of Ovarian Primordial Follicle Development

    Science.gov (United States)

    Nilsson, Eric E.; Savenkova, Marina I.; Schindler, Ryan; Zhang, Bin; Schadt, Eric E.; Skinner, Michael K.

    2010-01-01

    Ovarian primordial follicles are critical for female reproduction and comprise a finite pool of gametes arrested in development. A systems biology approach was used to identify regulatory gene networks essential for primordial follicle development. Transcriptional responses to eight different growth factors known to influence primordial follicles were used to construct a bionetwork of regulatory genes involved in rat primordial follicle development. Over 1,500 genes were found to be regulated by the various growth factors and a network analysis identified critical gene modules involved in a number of signaling pathways and cellular processes. A set of 55 genes was identified as potential critical regulators of these gene modules, and a sub-network associated with development was determined. Within the network two previously identified regulatory genes were confirmed (i.e., Pdgfa and Fgfr2) and a new factor was identified, connective tissue growth factor (CTGF). CTGF was tested in ovarian organ cultures and found to stimulate primordial follicle development. Therefore, the relevant gene network associated with primordial follicle development was validated and the critical genes and pathways involved in this process were identified. This is one of the first applications of network analysis to a normal developmental process. These observations provide insights into potential therapeutic targets for preventing ovarian disease and promoting female reproduction. PMID:20661288

  8. The origin, evolution and signatures of primordial magnetic fields.

    Science.gov (United States)

    Subramanian, Kandaswamy

    2016-07-01

    The universe is magnetized on all scales probed so far. On the largest scales, galaxies and galaxy clusters host magnetic fields at the micro Gauss level coherent on scales up to ten kpc. Recent observational evidence suggests that even the intergalactic medium in voids could host a weak  ∼  10(-16) Gauss magnetic field, coherent on Mpc scales. An intriguing possibility is that these observed magnetic fields are a relic from the early universe, albeit one which has been subsequently amplified and maintained by a dynamo in collapsed objects. We review here the origin, evolution and signatures of primordial magnetic fields. After a brief summary of magnetohydrodynamics in the expanding universe, we turn to magnetic field generation during inflation and phase transitions. We trace the linear and nonlinear evolution of the generated primordial fields through the radiation era, including viscous effects. Sensitive observational signatures of primordial magnetic fields on the cosmic microwave background, including current constraints from Planck, are discussed. After recombination, primordial magnetic fields could strongly influence structure formation, especially on dwarf galaxy scales. The resulting signatures on reionization, the redshifted 21 cm line, weak lensing and the Lyman-α forest are outlined. Constraints from radio and γ-ray astronomy are summarized. Astrophysical batteries and the role of dynamos in reshaping the primordial field are briefly considered. The review ends with some final thoughts on primordial magnetic fields.

  9. Gene bionetwork analysis of ovarian primordial follicle development.

    Directory of Open Access Journals (Sweden)

    Eric E Nilsson

    Full Text Available Ovarian primordial follicles are critical for female reproduction and comprise a finite pool of gametes arrested in development. A systems biology approach was used to identify regulatory gene networks essential for primordial follicle development. Transcriptional responses to eight different growth factors known to influence primordial follicles were used to construct a bionetwork of regulatory genes involved in rat primordial follicle development. Over 1,500 genes were found to be regulated by the various growth factors and a network analysis identified critical gene modules involved in a number of signaling pathways and cellular processes. A set of 55 genes was identified as potential critical regulators of these gene modules, and a sub-network associated with development was determined. Within the network two previously identified regulatory genes were confirmed (i.e., Pdgfa and Fgfr2 and a new factor was identified, connective tissue growth factor (CTGF. CTGF was tested in ovarian organ cultures and found to stimulate primordial follicle development. Therefore, the relevant gene network associated with primordial follicle development was validated and the critical genes and pathways involved in this process were identified. This is one of the first applications of network analysis to a normal developmental process. These observations provide insights into potential therapeutic targets for preventing ovarian disease and promoting female reproduction.

  10. The origin, evolution and signatures of primordial magnetic fields

    Science.gov (United States)

    Subramanian, Kandaswamy

    2016-07-01

    The universe is magnetized on all scales probed so far. On the largest scales, galaxies and galaxy clusters host magnetic fields at the micro Gauss level coherent on scales up to ten kpc. Recent observational evidence suggests that even the intergalactic medium in voids could host a weak  ˜  10-16 Gauss magnetic field, coherent on Mpc scales. An intriguing possibility is that these observed magnetic fields are a relic from the early universe, albeit one which has been subsequently amplified and maintained by a dynamo in collapsed objects. We review here the origin, evolution and signatures of primordial magnetic fields. After a brief summary of magnetohydrodynamics in the expanding universe, we turn to magnetic field generation during inflation and phase transitions. We trace the linear and nonlinear evolution of the generated primordial fields through the radiation era, including viscous effects. Sensitive observational signatures of primordial magnetic fields on the cosmic microwave background, including current constraints from Planck, are discussed. After recombination, primordial magnetic fields could strongly influence structure formation, especially on dwarf galaxy scales. The resulting signatures on reionization, the redshifted 21 cm line, weak lensing and the Lyman-α forest are outlined. Constraints from radio and γ-ray astronomy are summarized. Astrophysical batteries and the role of dynamos in reshaping the primordial field are briefly considered. The review ends with some final thoughts on primordial magnetic fields.

  11. Primordial Black Holes as Dark Matter

    CERN Document Server

    Carr, Bernard; Sandstad, Marit

    2016-01-01

    The possibility that the dark matter comprises primordial black holes (PBHs) is considered, with particular emphasis on the currently allowed mass windows at $10^{16}$ - $10^{17}\\,$g, $10^{20}$ - $10^{24}\\,$g and $1$ - $10^{3}\\,M_{\\odot}$. The Planck mass relics of smaller evaporating PBHs are also considered. All relevant constraints (lensing, dynamical, large-scale structure and accretion) are reviewed and various effects necessary for a precise calculation of the PBH abundance (non-Gaussianity, non-sphericity, critical collapse and merging) are accounted for. It is difficult to put all the dark matter in PBHs if their mass function is monochromatic but this is still possible if the mass function is extended, as expected in many scenarios. A novel procedure for confronting observational constraints with an extended PBH mass spectrum is therefore introduced. This applies for arbitrary constraints and a wide range of PBH formation models, and allows us to identify which model-independent conclusions can be dr...

  12. Primordial Black Holes and r -Process Nucleosynthesis

    Science.gov (United States)

    Fuller, George M.; Kusenko, Alexander; Takhistov, Volodymyr

    2017-08-01

    We show that some or all of the inventory of r -process nucleosynthesis can be produced in interactions of primordial black holes (PBHs) with neutron stars (NSs) if PBHs with masses 10-14 M⊙

  13. Primordial black holes in globular clusters

    Science.gov (United States)

    Sigurdsson, Steinn; Hernquist, Lars

    1993-01-01

    It has recently been recognized that significant numbers of medium-mass back holes (of order 10 solar masses) should form in globular clusters during the early stages of their evolution. Here we explore the dynamical and observational consequences of the presence of such a primordial black-hole population in a globular cluster. The holes initially segregate to the cluster cores, where they form binary and multiple black-hole systems. The subsequent dynamical evolution of the black-hole population ejects most of the holes on a relatively short timescale: a typical cluster will retain between zero and four black holes in its core, and possibly a few black holes in its halo. The presence of binary, triple, and quadruple black-hole systems in cluster cores will disrupt main-sequence and giant stellar binaries; this may account for the observed anomalies in the distribution of binaries in globular clusters. Furthermore, tidal interactions between a multiple black-hole system and a red giant star can remove much of the red giant's stellar envelope, which may explain the puzzling absence of larger red giants in the cores of some very dense clusters.

  14. The Primordial Inflation Explorer (PIXIE) Mission

    Science.gov (United States)

    Kogut, Alan J.; Chuss, David T.; Dotson, Jessie L.; Fixsen, Dale J.; Halpern, Mark; Hinshaw, Gary F.; Meyer, Stephan M.; Moseley, S. Harvey; Seiffert, Michael D.; Spergel, David N.; Wollack, Edward J.

    2011-01-01

    The Primordial Inflation Explorer (PIXIE) is an Explorer-class mission to map the absolute intensity and linear polarization of the cosmic microwave background and diffuse astrophysical foregrounds over the full sky from frequencies 30 GHz to 6 THz (I cm to 50 I-tm wavelength). PIXIE uses a polarizing Michelson interferometer with 2.7 K optics to measure the difference spectrum between two orthogonal linear polarizations from two co-aligned beams. Either input can view either the sky or a temperature-controlled absolute reference blackbody calibrator. The multimoded optics and high etendu provide sensitivity comparable to kilo-pixel focal plane arrays, but with greatly expanded frequency coverage while using only 4 detectors total. PIXIE builds on the highly successful COBEIFIRAS design by adding large-area polarization-sensitive detectors whose fully symmetric optics are maintained in thermal equilibrium with the CMB. The highly symmetric nulled design provides redundant rejection of major sources of systematic uncertainty. The principal science goal is the detection and characterization of linear polarization from an inflationary epoch in the early universe, with tensor-to-scalar ratio r much less than 10(exp -3). PIXIE will also return a rich data set constraining physical processes ranging from Big Bang cosmology, reionization, and large-scale structure to the local interstellar medium. Keywords: cosmic microwave background, polarization, FTS, bolometer

  15. Orbital eccentricities in primordial black holes binaries

    CERN Document Server

    Cholis, Ilias; Ali-Haïmoud, Yacine; Bird, Simeon; Kamionkowski, Marc; Muñoz, Julian B; Raccanelli, Alvise

    2016-01-01

    It was recently suggested that the merger of $\\sim30\\,M_\\odot$ primordial black holes (PBHs) may provide a significant number of events in gravitational-wave observatories over the next decade, if they make up an appreciable fraction of the dark matter. Here we show that measurement of the eccentricities of the inspiralling binary black holes can be used to distinguish these binaries from those produced by more traditional astrophysical mechanisms. These PBH binaries are formed on highly eccentric orbits and can then merge on timescales that in some cases are years or less, retaining some eccentricity in the last seconds before the merger. This is to be contrasted with massive-stellar-binary, globular-cluster, or other astrophysical origins for binary black holes (BBHs) in which the orbits have very effectively circularized by the time the BBH enters the observable LIGO window. Here we discuss the features of the gravitational-wave signals that indicate this eccentricity and forecast the sensitivity of LIGO a...

  16. Primordial power spectrum features and consequences

    CERN Document Server

    Goswami, Gaurav

    2014-01-01

    The present Cosmic Microwave Background (CMB) temperature and polarization anisotropy data is consistent with not only a power law scalar primordial power spectrum (PPS) with a small running but also with the scalar PPS having very sharp features. This has motivated inflationary models with such sharp features. Recently, even the possibility of having nulls in the power spectrum (at certain scales) has been considered. The existence of these nulls has been shown in linear perturbation theory. What shall be the effect of higher order corrections on such nulls? Inspired by this question, we attempt to calculate quantum radiative corrections to the Fourier transform of the two-point function in a toy field theory and address the issue of how these corrections to the power spectrum behave in models in which the tree-level power spectrum has a sharp dip (but not a null). In particular, we consider the possibility of the relative enhancement of radiative corrections in a model in which the tree-level spectrum goes ...

  17. The Primordial Inflation Polarization Explorer (PIPER)

    CERN Document Server

    Gandilo, Natalie N; Benford, Dominic; Bennett, Charles L; Chuss, David T; Dotson, Jessie L; Eimer, Joseph R; Fixsen, Dale J; Halpern, Mark; Hilton, Gene; Hinshaw, Gary F; Irwin, Kent; Jhabvala, Christine; Kimball, Mark; Kogut, Alan; Lowe, Luke; McMahon, Jeff J; Miller, Timothy M; Mirel, Paul; Moseley, S Harvey; Pawlyk, Samuel; Rodriguez, Samelys; Sharp, Elmer; Shirron, Peter; Staguhn, Johannes G; Sullivan, Dan F; Switzer, Eric R; Taraschi, Peter; Tucker, Carole E; Wollack, Edward J

    2016-01-01

    The Primordial Inflation Polarization ExploreR (PIPER) is a balloon-borne telescope designed to measure the polarization of the Cosmic Microwave Background on large angular scales. PIPER will map 85% of the sky at 200, 270, 350, and 600 GHz over a series of 8 conventional balloon flights from the northern and southern hemispheres. The first science flight will use two 32x40 arrays of backshort-under-grid transition edge sensors, multiplexed in the time domain, and maintained at 100 mK by a Continuous Adiabatic Demagnetization Refrigerator. Front-end cryogenic Variable-delay Polarization Modulators provide systematic control by rotating linear to circular polarization at 3 Hz. Twin telescopes allow PIPER to measure Stokes I, Q, U, and V simultaneously. The telescope is maintained at 1.5 K in an LHe bucket dewar. Cold optics and the lack of a warm window permit sensitivity at the sky-background limit. The ultimate science target is a limit on the tensor-to-scalar ratio of r ~ 0.007, from the reionization bump t...

  18. Primordial fluctuations from deformed quantum algebras

    Energy Technology Data Exchange (ETDEWEB)

    Day, Andrew C. [Department of Applied Mathematics, University of Western Ontario London, ON, Canada N6A 5B7 (Canada); Brown, Iain A. [Institute of Theoretical Astrophysics, University of Oslo P.O. Box 1029 Blindern, N-0315 Oslo (Norway); Seahra, Sanjeev S., E-mail: aday46@uwo.ca, E-mail: ibrown@astro.uio.no, E-mail: sseahra@unb.ca [Department of Mathematics and Statistics, University of New Brunswick Fredericton, NB, Canada E3B 5A3 (Canada)

    2014-03-01

    We study the implications of deformed quantum algebras for the generation of primordial perturbations from slow-roll inflation. Specifically, we assume that the quantum commutator of the inflaton's amplitude and momentum in Fourier space gets modified at energies above some threshold M{sub *}. We show that when the commutator is modified to be a function of the momentum only, the problem of solving for the post-inflationary spectrum of fluctuations is formally equivalent to solving a one-dimensional Schr and quot;odinger equation with a time dependent potential. Depending on the class of modification, we find results either close to or significantly different from nearly scale invariant spectra. For the former case, the power spectrum is characterized by step-like behaviour at some pivot scale, where the magnitude of the jump is O(H{sup 2}/M{sub *}{sup 2}). (H is the inflationary Hubble parameter.) We use our calculated power spectra to generate predictions for the cosmic microwave background and baryon acoustic oscillations, hence demonstrating that certain types of deformations are incompatible with current observations.

  19. Orbital eccentricities in primordial black hole binaries

    Science.gov (United States)

    Cholis, Ilias; Kovetz, Ely D.; Ali-Haïmoud, Yacine; Bird, Simeon; Kamionkowski, Marc; Muñoz, Julian B.; Raccanelli, Alvise

    2016-10-01

    It was recently suggested that the merger of ˜30 M⊙ primordial black holes (PBHs) may provide a significant number of events in gravitational-wave observatories over the next decade, if they make up an appreciable fraction of the dark matter. Here we show that measurement of the eccentricities of the inspiralling binary black holes can be used to distinguish these binaries from those produced by more traditional astrophysical mechanisms. These PBH binaries are formed on highly eccentric orbits and can then merge on time scales that in some cases are years or less, retaining some eccentricity in the last seconds before the merger. This is to be contrasted with massive-stellar-binary, globular-cluster, or other astrophysical origins for binary black holes (BBHs) in which the orbits have very effectively circularized by the time the BBH enters the observable LIGO window. Here we discuss the features of the gravitational-wave signals that indicate this eccentricity and forecast the sensitivity of LIGO and the Einstein Telescope to such effects. We show that if PBHs make up the dark matter, then roughly one event should have a detectable eccentricity given LIGO's expected sensitivity and observing time of six years. The Einstein Telescope should see O (10 ) such events after ten years.

  20. Electroweak baryogenesis and primordial hypermagnetic fields

    CERN Document Server

    Piccinelli, Gabriella

    2004-01-01

    The origin of the matter-antimatter asymmetry of the universe remains one of the outstanding questions yet to be answered by modern cosmology and also one of only a handful of problems where the need of a larger number of degrees of freedom than those contained in the standard model (SM) is better illustrated. An appealing scenario for the generation of baryon number is the electroweak phase transition that took place when the temperature of the universe was about 100 GeV. Though in the minimal version of the SM, and without considering the interaction of the SM particles with additional degrees of freedom, this scenario has been ruled out given the current bounds for the Higgs mass, this still remains an open possibility in supersymmetric extensions of the SM. In recent years it has also been realized that large scale magnetic fields could be of primordial origin. A natural question is what effect, if any, these fields could have played during the electroweak phase transition in connection to the generation ...

  1. Primordial gravitational waves in running vacuum cosmologies

    Science.gov (United States)

    Tamayo, D. A.; Lima, J. A. S.; Alves, M. E. S.; de Araujo, J. C. N.

    2017-01-01

    We investigate the cosmological production of gravitational waves in a nonsingular flat cosmology powered by a "running vacuum" energy density described by ρΛ ≡ ρΛ(H), a phenomenological expression potentially linked with the renormalization group approach in quantum field theory in curved spacetimes. The model can be interpreted as a particular case of the class recently discussed by Perico et al. (2013) [25] which is termed complete in the sense that the cosmic evolution occurs between two extreme de Sitter stages (early and late time de Sitter phases). The gravitational wave equation is derived and its time-dependent part numerically integrated since the primordial de Sitter stage. The generated spectrum of gravitons is also compared with the standard calculations where an abrupt transition, from the early de Sitter to the radiation phase, is usually assumed. It is found that the stochastic background of gravitons is very similar to the one predicted by the cosmic concordance model plus inflation except at higher frequencies (ν ≳ 100 kHz). This remarkable signature of a "running vacuum" cosmology combined with the proposed high frequency gravitational wave detectors and measurements of the CMB polarization (B-modes) may provide a new window to confront more conventional models of inflation.

  2. The Primordial Inflation Explorer (PIXIE) Mission

    Science.gov (United States)

    Kogut, Alan J.; Chuss, David T.; Dotson, Jessie L.; Fixsen, Dale J.; Halpern, Mark; Hinshaw, Gary F.; Meyer, Stephan M.; Moseley, S. Harvey; Seiffert, Michael D.; Spergel, David N.; Wollack, Edward J.

    2010-07-01

    The Primordial Inflation Explorer (PIXIE) is an Explorer-class mission to map the absolute intensity and linear polarization of the cosmic microwave background and diffuse astrophysical foregrounds over the full sky from frequencies 30 GHz to 6 THz (1 cm to 50 μm wavelength). PIXIE uses a polarizing Michelson interferometer with 2.7 K optics to measure the difference spectrum between two orthogonal linear polarizations from two co-aligned beams. Either input can view either the sky or a temperature-controlled absolute reference blackbody calibrator. The multimoded optics and high etendu provide sensitivity comparable to kilo-pixel focal plane arrays, but with greatly expanded frequency coverage while using only 4 detectors total. PIXIE builds on the highly successful COBE/FIRAS design by adding large-area polarization-sensitive detectors whose fully symmetric optics are maintained in thermal equilibrium with the CMB. The highly symmetric nulled design provides redundant rejection of major sources of systematic uncertainty. The principal science goal is the detection and characterization of linear polarization from an inflationary epoch in the early universe, with tensor-to-scalar ratio r << 10-3. PIXIE will also return a rich data set constraining physical processes ranging from Big Bang cosmology, reionization, and large-scale structure to the local interstellar medium.

  3. Primordial fluctuations from deformed quantum algebras

    CERN Document Server

    Day, Andrew C; Seahra, Sanjeev S

    2013-01-01

    We study the implications of deformed quantum algebras for the generation of primordial perturbations from slow-roll inflation. Specifically, we assume that the quantum commutator of the inflaton's amplitude and momentum in Fourier space gets modified at energies above some threshold $M_{\\star}$. We show that when the commutator is modified to be a function of the momentum only, the problem of solving for the post-inflationary spectrum of fluctuations is formally equivalent to solving a one-dimensional Schr\\"odinger equation with a time dependent potential. Depending on the class of modification, we find results either close to or significantly different from nearly scale invariant spectra. For the former case, the power spectrum is characterized by step-like behaviour at some pivot scale, where the magnitude of the jump is $\\mathcal{O}(H^{2}/M_{\\star}^{2})$. ($H$ is the inflationary Hubble parameter.) We use our calculated power spectra to generate predictions for the cosmic microwave background and baryon a...

  4. The Primordial Inflation Polarization Explorer (PIPER)

    CERN Document Server

    Lazear, Justin; Benford, Dominic; Bennett, Charles L; Chuss, David T; Dotson, Jessie L; Eimer, Joseph R; Fixsen, Dale J; Halpern, Mark; Hilton, Gene; Hinderks, James; Hinshaw, Gary F; Irwin, Kent; Jhabvala, Christine; Johnson, Bradley; Kogut, Alan; Lowe, Luke; McMahon, Jeff J; Miller, Timothy M; Mirel, Paul; Moseley, S Harvey; Rodriguez, Samelys; Sharp, Elmer; Staguhn, Johannes G; Switzer, Eric R; Tucker, Carole E; Weston, Amy; Wollack, Edward J

    2014-01-01

    The Primordial Inflation Polarization Explorer (PIPER) is a balloon-borne cosmic microwave background (CMB) polarimeter designed to search for evidence of inflation by measuring the large-angular scale CMB polarization signal. BICEP2 recently reported a detection of B-mode power corresponding to the tensor-to-scalar ratio r = 0.2 on ~2 degree scales. If the BICEP2 signal is caused by inflationary gravitational waves (IGWs), then there should be a corresponding increase in B-mode power on angular scales larger than 18 degrees. PIPER is currently the only suborbital instrument capable of fully testing and extending the BICEP2 results by measuring the B-mode power spectrum on angular scales $\\theta$ = ~0.6 deg to 90 deg, covering both the reionization bump and recombination peak, with sensitivity to measure the tensor-to-scalar ratio down to r = 0.007, and four frequency bands to distinguish foregrounds. PIPER will accomplish this by mapping 85% of the sky in four frequency bands (200, 270, 350, 600 GHz) over a ...

  5. Characterisation and germline transmission of cultured avian primordial germ cells.

    Directory of Open Access Journals (Sweden)

    Joni Macdonald

    Full Text Available BACKGROUND: Avian primordial germ cells (PGCs have significant potential to be used as a cell-based system for the study and preservation of avian germplasm, and the genetic modification of the avian genome. It was previously reported that PGCs from chicken embryos can be propagated in culture and contribute to the germ cell lineage of host birds. PRINCIPAL FINDINGS: We confirm these results by demonstrating that PGCs from a different layer breed of chickens can be propagated for extended periods in vitro. We demonstrate that intracellular signalling through PI3K and MEK is necessary for PGC growth. We carried out an initial characterisation of these cells. We find that cultured PGCs contain large lipid vacuoles, are glycogen rich, and express the stem cell marker, SSEA-1. These cells also express the germ cell-specific proteins CVH and CDH. Unexpectedly, using RT-PCR we show that cultured PGCs express the pluripotency genes c-Myc, cKlf4, cPouV, cSox2, and cNanog. Finally, we demonstrate that the cultured PGCs will migrate to and colonise the forming gonad of host embryos. Male PGCs will colonise the female gonad and enter meiosis, but are lost from the gonad during sexual development. In male hosts, cultured PGCs form functional gametes as demonstrated by the generation of viable offspring. CONCLUSIONS: The establishment of in vitro cultures of germline competent avian PGCs offers a unique system for the study of early germ cell differentiation and also a comparative system for mammalian germ cell development. Primary PGC lines will form the basis of an alternative technique for the preservation of avian germplasm and will be a valuable tool for transgenic technology, with both research and industrial applications.

  6. Molecular diagnosis of putative Stargardt disease by capture next generation sequencing.

    Science.gov (United States)

    Zhang, Xiao; Ge, Xianglian; Shi, Wei; Huang, Ping; Min, Qingjie; Li, Minghan; Yu, Xinping; Wu, Yaming; Zhao, Guangyu; Tong, Yi; Jin, Zi-Bing; Qu, Jia; Gu, Feng

    2014-01-01

    Stargardt Disease (STGD) is the commonest genetic form of juvenile or early adult onset macular degeneration, which is a genetically heterogeneous disease. Molecular diagnosis of STGD remains a challenge in a significant proportion of cases. To address this, seven patients from five putative STGD families were recruited. We performed capture next generation sequencing (CNGS) of the probands and searched for potentially disease-causing genetic variants in previously identified retinal or macular dystrophy genes. Seven disease-causing mutations in ABCA4 and two in PROM1 were identified by CNGS, which provides a confident genetic diagnosis in these five families. We also provided a genetic basis to explain the differences among putative STGD due to various mutations in different genes. Meanwhile, we show for the first time that compound heterozygous mutations in PROM1 gene could cause cone-rod dystrophy. Our findings support the enormous potential of CNGS in putative STGD molecular diagnosis.

  7. The Formation of Primordial Luminous Objects

    Energy Technology Data Exchange (ETDEWEB)

    Ripamonti, Emanuele; /Kapteyn Astron. Inst., Groningen; Abel, Tom; /KIPAC, Menlo Park

    2005-08-04

    The scientific belief that the universe evolves in time is one of the legacies of the theory of the Big Bang. The concept that the universe has an history started to attract the interest of cosmologists soon after the first formulation of the theory: already Gamow (1948; 1949) investigated how and when galaxies could have been formed in the context of the expanding Universe. However, the specific topic of the formation (and of the fate) of the first objects dates to two decades later, when no objects with metallicities as low as those predicted by primordial nucleosynthesis (Z {approx}< 10{sup -10} {approx} 10{sup -8}Z{sub {circle_dot}}) were found. Such concerns were addressed in two seminal papers by Peebles & Dicke (1968; hereafter PD68) and by Doroshkevich, Zel'Dovich & Novikov (1967; hereafter DZN67), introducing the idea that some objects could have formed before the stars we presently observe. (1) Both PD68 and DZN67 suggest a mass of {approx} 10{sup 5} M{sub {circle_dot}} for the first generation of bound systems, based on the considerations on the cosmological Jeans length (Gamow 1948; Peebles 1965) and the possible shape of the power spectrum. (2) They point out the role of thermal instabilities in the formation of the proto-galactic bound object, and of the cooling of the gas inside it; in particular, PD68 introduces H{sub 2} cooling and chemistry in the calculations about the contraction of the gas. (3) Even if they do not specifically address the occurrence of fragmentation, these papers make two very different assumptions: PD68 assumes that the gas will fragment into ''normal'' stars to form globular clusters, while DZN67 assumes that fragmentation does not occur, and that a single ''super-star'' forms. (4) Finally, some feedback effects as considered (e.g. Peebles & Dicke considered the effects of supernovae). Today most of the research focuses on the issues when fragmentation may occur, what objects are

  8. Primordial Inflation Polarization Explorer (Phase 3)

    Science.gov (United States)

    Kogut, Alan

    This is the Lead Proposal for the investigation "Primordial Inflation Polarization Explorer (Phase 3)". We propose to complete and fly the Primordial Inflation Polarization Explorer (PIPER) to measure the polarization of the cosmic microwave background (CMB) and search for the imprint of gravitational waves produced during an inflationary epoch in the early universe. Detection of the inflationary signal would have profound consequences for both cosmology and high-energy physics. Not only would it establish inflation as a physical reality, it would provide a direct, model-independent determination of the relevant energy scale, shedding light on physics at energies twelve orders of magnitude beyond those accessible to direct experimentation in particle accelerators. The recent detection of CMB polarization by the BICEP2 instrument brings new urgency to the field. The BICEP2 detection at degree angular scales is consistent with inflation, but the amplitude is a factor of two higher than upper limits set by unpolarized data. A critical test is the rise in power at large angular scales predicted by inflation. Detecting this rise would confirm the signal's inflationary origin, fulfilling a long quest for cosmology while providing new insight into physics at the highest energies. PIPER is the only suborbital instrument capable of measuring CMB polarization on the large angular scales needed to test an inflationary origin for the BICEP2 detection. PIPER is a balloon-borne instrument, optimized to detect the inflationary signal on large angular scales. It consists of two co-aligned telescopes cooled to 1.5 K within a large liquid helium bucket dewar. A variable-delay polarization modulator (VPM) on each telescope chops between linear and circular polarization to isolate the polarized signal while rejecting the much brighter unpolarized emission. Four 32 x 40 element detector arrays provide background-limited sensitivity. A series of flights from mid-latitude sites will map

  9. The Primordial Inflation Polarization Explorer (PIPER)

    Science.gov (United States)

    Lazear, Justin Scott; Ade, Peter A.; Benford, Dominic J.; Bennett, Charles L.; Chuss, David T.; Dotson, Jessie L.; Eimer, Joseph R.; Fixsen, Dale J.; Halpern, Mark; Hinderks, James; Hinshaw, Gary F.; Irwin, Kent; Jhabvala, Christine; Johnson, Bradley; Kogut, Alan; Lowe, Luke; McMahon, Jeff J.; Miller, Timothy M.; Mirel, Paul; Moseley, S. Harvey; Rodriguez, Samelys; Staguhn, Johannes G.; Switzer, Eric R.; Tucker, Carole E.; Weston, Amy; Wollack, Edward

    2014-01-01

    The Primordial Inflation Polarization ExploreR (Piper) is a balloon-borne cosmic microwave background (CMB) polarimeter designed to search for evidence of inflation by measuring the large-angular scale CMB polarization signal. Bicep2 recently reported a detection of B-mode power corresponding to the tensor-to-scalar ratio r = 0.2 on approximately 2 degree scales. If the Bicep2 signal is caused by inflationary gravitational waves (IGWs), then there should be a corresponding increase in B-mode power on angular scales larger than 18 degrees. Piper is currently the only suborbital instrument capable of fully testing and extending the Bicep2 results by measuring the B-mode power spectrum on angular scales theta ? = approximately 0.6 deg to 90 deg, covering both the reionization bump and recombination peak, with sensitivity to measure the tensor-to-scalar ratio down to r = 0.007, and four frequency bands to distinguish foregrounds. Piper will accomplish this by mapping 85% of the sky in four frequency bands (200, 270, 350, 600 GHz) over a series of 8 conventional balloon flights from the northern and southern hemispheres. The instrument has background-limited sensitivity provided by fully cryogenic (1.5 K) optics focusing the sky signal onto four 32×40-pixel arrays of time-domain multiplexed Transition-Edge Sensor (TES) bolometers held at 140 milli-Kelvin. Polarization sensitivity and systematic control are provided by front-end Variabledelay Polarization Modulators (VPMs), which rapidly modulate only the polarized sky signal at 3 Hz and allow Piper to instantaneously measure the full Stokes vector (I,Q,U,0V) for each pointing. We describe the Piper instrument and progress towards its first flight.

  10. Primordial black holes as dark matter

    Science.gov (United States)

    Carr, Bernard; Kühnel, Florian; Sandstad, Marit

    2016-10-01

    The possibility that the dark matter comprises primordial black holes (PBHs) is considered, with particular emphasis on the currently allowed mass windows at 1 016- 1 017 g , 1 020- 1 024 g and 1 - 1 03M⊙ . The Planck mass relics of smaller evaporating PBHs are also considered. All relevant constraints (lensing, dynamical, large-scale structure and accretion) are reviewed and various effects necessary for a precise calculation of the PBH abundance (non-Gaussianity, nonsphericity, critical collapse and merging) are accounted for. It is difficult to put all the dark matter in PBHs if their mass function is monochromatic but this is still possible if the mass function is extended, as expected in many scenarios. A novel procedure for confronting observational constraints with an extended PBH mass spectrum is therefore introduced. This applies for arbitrary constraints and a wide range of PBH formation models and allows us to identify which model-independent conclusions can be drawn from constraints over all mass ranges. We focus particularly on PBHs generated by inflation, pointing out which effects in the formation process influence the mapping from the inflationary power spectrum to the PBH mass function. We then apply our scheme to two specific inflationary models in which PBHs provide the dark matter. The possibility that the dark matter is in intermediate-mass PBHs of 1 - 1 03M⊙ is of special interest in view of the recent detection of black-hole mergers by LIGO. The possibility of Planck relics is also intriguing but virtually untestable.

  11. The Primordial Inflation Polarization Explorer (PIPER)

    Science.gov (United States)

    Chuss, David T.; Ade, Peter A. R.; Benford, Dominic J.; Bennett, Charles L.; Dotson, Jessie L.; Eimer, Joseph R.; Fixsen, Dale J.; Halpern, Mark; Hilton, Gene; Hinderks, James; hide

    2010-01-01

    The Primordial Inflation Polarization Explorer (PIPER) is it balloon-borne instrument designed to search for the faint signature of inflation in the polarized component of the cosmic microwave background (C-N-113). Each flight will be configured for a single frequency, but in order to aid in the removal of the polarized foreground signal due to Galactic dust, the filters will be changed between flights. In this way, the CMB polarization at a total of four different frequencies (200, 270, 350, and 600 GHz) will be, measured on large angular scales. PIPER consists of a pair of cryogenic telescopes, one for measuring each of Stokes Q and U in the instrument frame. Each telescope receives both linear orthogonal polarizations in two 32 x 40 element planar arrays that utilize Transition-Edge Sensors (TES). The first element in each telescope is a variable-delay polarization modulator (VPM) that fully modulates the linear Stokes parameter to which the telescope is sensitive. There are several advantages to this architecture. First, by modulating at the front of the optics, instrumental polarization is unmodulated and is therefore cleanly separated from source polarization. Second, by implementing this system with the appropriate symmetry, systematic effects can be further mitigated. In the PIPER design, many of the. systematics are manifest in the unmeasured linear Stokes parameter for each telescope and this can be separated from the desired signal. Finally, the modulation cycle never mixes the Q and U linear Stokes parameters, and thus residuals in the modulation do not twist the observed polarization vector. This is advantageous because measuring the angle of linear polarization is critical for separating the inflationary signal from other polarized components.

  12. PRISM: Recovery of the primordial spectrum from Planck data

    CERN Document Server

    Lanusse, F; Starck, J -L; Sureau, F; Bobin, J

    2014-01-01

    The primordial power spectrum describes the initial perturbations that seeded the large-scale structure we observe today. It provides an indirect probe of inflation or other structure-formation mechanisms. In this letter, using our recently published PRISM algorithm, we recover the primordial power spectrum from Planck PR1 dataset. PRISM is a sparsity-based inversion method, which aims at recovering features in the primordial power spectrum from the empirical power spectrum of the Cosmic Microwave Background (CMB). The ill-posed inverse problem involved is regularised using a sparsity prior on features in the primordial power spectrum in a wavelet dictionary. Although this non-parametric method does not assume a strong prior on the shape of the primordial power spectrum, it is able to recover both its global shape and localised features. As a results, this approach presents a robust way of detecting deviations from the currently favoured scale-invariant spectrum. We apply PRISM to 100 Planck simulated data to...

  13. Primordial image and the archetypal design of art.

    Science.gov (United States)

    Johnson, N B

    1991-07-01

    This paper extends Jung's work on the relationship of art to (postulated) archetypes of the collective unconscious. Archetypes of the collective unconscious, according to Jung, are revealed to ego consciousness only by way of images--images of a specific form. Jung suggests that archetypes, primordial images, combine two aspects in a single form and are therefore paradoxical. The wise old man and youth and hermaphrodites illustrate Jung's definition of a primordial image. My study of Jung's illustrations concludes that he is referring to what I term double-figures as the design form of primordial imagery. I elaborate upon the design form of double-figures, and illustrate my conception of archetypal imagery through comparative analysis of nine cases of double-figure imagery from selected prehistoric and contemporary societies. Double-figures, as archetypal primordial imagery of the collective unconscious, are spontaneously generated, autonomous, and known to a wide variety of societies. I distinguish between form and content in the study of primordial imagery, and conclude with a summary of the importance of Jung to the cross-cultural study of art.

  14. Direct search for features in the primordial bispectrum

    Directory of Open Access Journals (Sweden)

    Stephen Appleby

    2016-09-01

    Full Text Available We study features in the bispectrum of the primordial curvature perturbation correlated with the reconstructed primordial power spectrum from the observed cosmic microwave background temperature data. We first show how the bispectrum can be completely specified in terms of the power spectrum and its first two derivatives, valid for any configuration of interest. Then using a model-independent reconstruction of the primordial power spectrum from the Planck angular power spectrum of temperature anisotropies, we compute the bispectrum in different triangular configurations. We find that in the squeezed limit at k∼0.06 Mpc−1 and k∼0.014 Mpc−1 there are marginal 2σ deviations from the standard featureless bispectrum, which meanwhile is consistent with the reconstructed bispectrum in the equilateral configuration.

  15. Mechanisms and pathways of growth failure in primordial dwarfism

    Science.gov (United States)

    Klingseisen, Anna; Jackson, Andrew P.

    2011-01-01

    The greatest difference between species is size; however, the developmental mechanisms determining organism growth remain poorly understood. Primordial dwarfism is a group of human single-gene disorders with extreme global growth failure (which includes Seckel syndrome, microcephalic osteodysplastic primordial dwarfism I [MOPD] types I and II, and Meier-Gorlin syndrome). Ten genes have now been identified for microcephalic primordial dwarfism, encoding proteins involved in fundamental cellular processes including genome replication (ORC1 [origin recognition complex 1], ORC4, ORC6, CDT1, and CDC6), DNA damage response (ATR [ataxia-telangiectasia and Rad3-related]), mRNA splicing (U4atac), and centrosome function (CEP152, PCNT, and CPAP). Here, we review the cellular and developmental mechanisms underlying the pathogenesis of these conditions and address whether further study of these genes could provide novel insight into the physiological regulation of organism growth. PMID:21979914

  16. Effects of active-sterile neutrino mixing during primordial nucleosynthesis

    CERN Document Server

    Civitarese, Osvaldo; Saez, Maria Manuela

    2016-01-01

    In the present work, we discuss the effects of the inclusion of sterile-active neutrino oscillations during the production of primordial light-nuclei. We assume that the sterile neutrino mass-eigenstate might oscillate with the two lightest active neutrino mass- eigenstates, with mixing angles ${\\phi}_1$ and ${\\phi}_2$. We also allow a constant renormalization (represented by a parameter (${\\zeta}$)) of the sterile neutrino occupation factor. Taking ${\\zeta}$ and the mixing angles as free parameters, we have computed distribution functions of active and sterile neutrinos and primordial abundances. Using observable data we set constrains in the free parameters of the model. It is found that the data on primordial abundances are consistent with small mixing angles and with a value of ${\\zeta}$ smaller than 0.65 at 3${\\sigma}$ level.

  17. The Future of Primordial Features with 21 cm Tomography

    CERN Document Server

    Chen, Xingang; Münchmeyer, Moritz

    2016-01-01

    Detecting a deviation from a featureless primordial power spectrum of fluctuations would give profound insight into the physics of the primordial Universe. Depending on their nature, primordial features can either provide direct evidence for the inflation scenario or pin down details of the inflation model. Thus far, using the cosmic microwave background (CMB) we have only been able to put stringent constraints on the amplitude of features, but no significant evidence has been found for such signals. Here we explore the limit of the experimental reach in constraining such features using 21 cm tomography at high redshift. A measurement of the 21 cm power spectrum from the Dark Ages is generally considered as the ideal experiment for early Universe physics, with potentially access to a large number of modes. We consider three different categories of theoretically motivated models: the sharp feature models, resonance models, and standard clock models. We study the improvements on bounds on features as a function...

  18. Reconstructing the primordial power spectrum from the CMB

    Energy Technology Data Exchange (ETDEWEB)

    Gauthier, Christopher; Bucher, Martin, E-mail: cgauthie@apc.univ-paris7.fr, E-mail: bucher@apc.univ-paris7.fr [Laboratoire APC, Université Paris Diderot, Bâtiment Condorcet, 10 rue Alice Domon et Léonie Duquet, 75205 Paris Cedex 13 (France)

    2012-10-01

    We propose a straightforward and model independent methodology for characterizing the sensitivity of CMB and other experiments to wiggles, irregularities, and features in the primordial power spectrum. Assuming that the primordial cosmological perturbations are adiabatic, we present a function space generalization of the usual Fisher matrix formalism applied to a CMB experiment resembling Planck with and without ancillary data. This work is closely related to other work on recovering the inflationary potential and exploring specific models of non-minimal, or perhaps baroque, primordial power spectra. The approach adopted here, however, most directly expresses what the data is really telling us. We explore in detail the structure of the available information and quantify exactly what features can be reconstructed and at what statistical significance.

  19. Reconstructing the primordial power spectrum from the CMB

    CERN Document Server

    Gauthier, Christopher

    2012-01-01

    We propose a straightforward and model independent methodology for characterizing the sensitivity of CMB and other experiments to wiggles, irregularities, and features in the primordial power spectrum. Assuming that the primordial cosmological perturbations are adiabatic, we present a function space generalization of the usual Fisher matrix formalism, applied to a CMB experiment resembling Planck with and without ancillary data. This work is closely related to other work on recovering the inflationary potential and exploring specific models of non-minimal, or perhaps baroque, primordial power spectra. The approach adopted here, however, most directly expresses what the data is really telling us. We explore in detail the structure of the available information and quantify exactly what features can be reconstructed and at what statistical significance.

  20. [Persistence of the primordial vitreous body and buphthalmos].

    Science.gov (United States)

    Cernea, P; Simionescu, C; Bosun, I

    1995-01-01

    Persistence of the hyperplasic primordial vitreous body is determined by a deletion of embryonal development of the vitreous body and of the hyaloid vascular system. Infant aged 3.5 years presents persistence of primordial vitreous body with crystalline dislocation in the camera aquosa and secondary buphthalmos of the left eye and microphthalmos with dislocation of the crystalline in the vitreous body of the right eye. At the back of the right eye we noticed a whitish mass, richly vascularized with vestiges from the hyaloid artery, but the posterior half of the vitreous cavity is filled with microscopic blood; the fibrovascular membrane is made of conjunctive tissue set in parallel layers and vessels with macrolipophagic degeneration. Microscopic investigation of retina reveals glial hyperplasia zones in the neighbourhood of the vitreous body. In the present paper the authors show the persistence of the primordial vitreous body in the left eye and bilateral dislocation of the crystalline, revealing multiple ocular malformations.

  1. Mechanisms and pathways of growth failure in primordial dwarfism.

    Science.gov (United States)

    Klingseisen, Anna; Jackson, Andrew P

    2011-10-01

    The greatest difference between species is size; however, the developmental mechanisms determining organism growth remain poorly understood. Primordial dwarfism is a group of human single-gene disorders with extreme global growth failure (which includes Seckel syndrome, microcephalic osteodysplastic primordial dwarfism I [MOPD] types I and II, and Meier-Gorlin syndrome). Ten genes have now been identified for microcephalic primordial dwarfism, encoding proteins involved in fundamental cellular processes including genome replication (ORC1 [origin recognition complex 1], ORC4, ORC6, CDT1, and CDC6), DNA damage response (ATR [ataxia-telangiectasia and Rad3-related]), mRNA splicing (U4atac), and centrosome function (CEP152, PCNT, and CPAP). Here, we review the cellular and developmental mechanisms underlying the pathogenesis of these conditions and address whether further study of these genes could provide novel insight into the physiological regulation of organism growth.

  2. Lhx8 regulates primordial follicle activation and postnatal folliculogenesis.

    Science.gov (United States)

    Ren, Yu; Suzuki, Hitomi; Jagarlamudi, Krishna; Golnoski, Kayla; McGuire, Megan; Lopes, Rita; Pachnis, Vassilis; Rajkovic, Aleksandar

    2015-06-16

    The early stages of ovarian follicle formation-beginning with the breakdown of germ cell cysts and continuing with the formation of primordial follicles and transition to primary and secondary follicles-are critical in determining reproductive life span and fertility. Previously, we discovered that global knockouts of germ cell-specific transcriptional co-regulators Sohlh1, Sohlh2, Lhx8, and Nobox, cause rapid oocyte loss and ovarian failure. Also factors such as Nobox and Sohlh1 are associated with human premature ovarian failure. In this study, we developed a conditional knockout of Lhx8 to study oocyte-specific pathways in postnatal folliculogenesis. The conditional deficiency of Lhx8 in the oocytes of primordial follicles leads to massive primordial oocyte activation, in part, by indirectly interacting with the PI3K-AKT pathway, as shown by synergistic effects on FOXO3 nucleocytoplasmic translocation and rpS6 activation. However, LHX8 does not directly regulate members of the PI3K-AKT pathway; instead, we show that LHX8 represses Lin28a expression, a known regulator of mammalian metabolism and of the AKT/mTOR pathway. LHX8 can bind to the Lin28a promoter, and the depletion of Lin28a in Lhx8-deficient oocytes partially suppresses primordial oocyte activation. Moreover, unlike the PI3K-AKT pathway, LHX8 is critical beyond primordial follicle activation, and blocks the primary to secondary follicle transition. Our results indicate that the LHX8-LIN28A pathway is essential in the earliest stages of primordial follicle activation, and LHX8 is an important oocyte-specific transcription factor in the ovary for regulating postnatal folliculogenesis.

  3. Major Quantitative Trait Loci and Putative Candidate Genes for Powdery Mildew Resistance and Fruit-Related Traits Revealed by an Intraspecific Genetic Map for Watermelon (Citrullus lanatus var. lanatus).

    Science.gov (United States)

    Kim, Kwang-Hwan; Hwang, Ji-Hyun; Han, Dong-Yeup; Park, Minkyu; Kim, Seungill; Choi, Doil; Kim, Yongjae; Lee, Gung Pyo; Kim, Sun-Tae; Park, Young-Hoon

    2015-01-01

    An intraspecific genetic map for watermelon was constructed using an F2 population derived from 'Arka Manik' × 'TS34' and transcript sequence variants and quantitative trait loci (QTL) for resistance to powdery mildew (PMR), seed size (SS), and fruit shape (FS) were analyzed. The map consists of 14 linkage groups (LGs) defined by 174 cleaved amplified polymorphic sequences (CAPS), 2 derived-cleaved amplified polymorphic sequence markers, 20 sequence-characterized amplified regions, and 8 expressed sequence tag-simple sequence repeat markers spanning 1,404.3 cM, with a mean marker interval of 6.9 cM and an average of 14.6 markers per LG. Genetic inheritance and QTL analyses indicated that each of the PMR, SS, and FS traits is controlled by an incompletely dominant effect of major QTLs designated as pmr2.1, ss2.1, and fsi3.1, respectively. The pmr2.1, detected on chromosome 2 (Chr02), explained 80.0% of the phenotypic variation (LOD = 30.76). This QTL was flanked by two CAPS markers, wsb2-24 (4.00 cM) and wsb2-39 (13.97 cM). The ss2.1, located close to pmr2.1 and CAPS marker wsb2-13 (1.00 cM) on Chr02, explained 92.3% of the phenotypic variation (LOD = 68.78). The fsi3.1, detected on Chr03, explained 79.7% of the phenotypic variation (LOD = 31.37) and was flanked by two CAPS, wsb3-24 (1.91 cM) and wsb3-9 (7.00 cM). Candidate gene-based CAPS markers were developed from the disease resistance and fruit shape gene homologs located on Chr.02 and Chr03 and were mapped on the intraspecific map. Colocalization of these markers with the major QTLs indicated that watermelon orthologs of a nucleotide-binding site-leucine-rich repeat class gene containing an RPW8 domain and a member of SUN containing the IQ67 domain are candidate genes for pmr2.1 and fsi3.1, respectively. The results presented herein provide useful information for marker-assisted breeding and gene cloning for PMR and fruit-related traits.

  4. Accretion of radiation and Primordial black holes in anisotropic universe

    CERN Document Server

    Mahapatra, Swapna

    2013-01-01

    We consider Primordial black holes (PBHs) in a LRS (locally rotationally symmetric) Bianchi-I anisotropic space time and study the effect of accretion of radiation in the radiation dominated era. We show that the life time of PBHs in anisotropic universe becomes longer by accretion of radiation. We generalize the result by including nonzero angular momentum parameter and study the PBH evolution equation. We find that the evaporation time gets prolonged and it depends on the accretion efficiency as well as angular momentum parameter. This supports the conjecture that Primordial black holes can be considered as a viable candidate for dark matter.

  5. Primordial gravitational waves from the space-condensate inflation model

    CERN Document Server

    Koh, Seoktae; Tumurtushaa, Gansukh

    2015-01-01

    We consider the space-condensate inflation model to study the primordial gravitational waves generated in the early Universe. We calculate the energy spectrum of gravitational waves induced by the space-condensate inflation model for full frequency range with assumption that the phase transition between two consecutive regimes to be abrupt during evolution of the Universe. The suppression of energy spectrum is found in our model for the decreasing frequency of gravitational waves depending on the model parameter. To realize the suppression of energy spectrum of the primordial gravitational waves, we study an existence of the early phase transition during inflation for the space-condensate inflation model.

  6. Chirality oscillation of primordial gravitational waves during inflation

    CERN Document Server

    Cai, Yong; Piao, Yun-Song

    2016-01-01

    We show that if the gravitational Chern-Simons term couples to a massive scalar field ($m>H$), the primordial gravitational waves (GWs) will show itself the chirality oscillation, i.e., the amplitudes of the left- and right-handed GWs modes will convert into each other and oscillate in their propagations. This oscillation will eventually develop a permanent difference of the amplitudes of both modes, which leads to nearly opposite oscillating shapes in the power spectra of the left- and right-handed primordial GWs. We discuss its implication to the CMB B-mode polarization.

  7. Propagating speed of primordial gravitational waves and inflation

    CERN Document Server

    Cai, Yong; Piao, Yun-Song

    2016-01-01

    We show that if the propagating speed of gravitational waves (GWs) gradually diminishes during inflation, the power spectrum of primordial GWs will be strongly blue, while that of the primordial scalar perturbation may be unaffected. We also illustrate that such a scenario is actually a disformal dual to the superinflation, but has no the ghost instability. The blue tilt obtained is $0

  8. The Thermal Sunyaev-Zeldovich Effect of Primordial Recombination Radiation

    CERN Document Server

    Kholupenko, E E; Ivanchik, A V; Varshalovich, D A

    2014-01-01

    It is well known that recombination radiation of primordial hydrogen-helium plasma leads to the distortions of the planckian spectrum shape of the cosmic microwave background radiation (CMB). We discuss the thermal Sunayev-Zeldovich (SZ) effect with taking into account primordial recombination radiation (PRR). Since in the thermal SZ effect the redistribution of the photons depends on the derivatives of the spectrum, the value of relative correction to SZ effect due to PRR significantly higher than relative corrections due to PRR in the initial spectrum. Calculations of corrections to the thermal SZ effect due to PRR show that depending on the cluster parameters: 1) in the range of frequencies $\

  9. Formalism for Primordial Black Hole Formation in Spherical Symmetry

    CERN Document Server

    Bloomfield, Jolyon; Face, Stephen

    2015-01-01

    We present a comprehensive formalism for the description of primordial black hole formation in spherical symmetry based on the formalisms of Misner, Sharp, and Hernandez, which can be used to predict whether or not a black hole will form, and extract the resulting black hole mass when formation does occur. Rigorous derivations of all aspects of the formalism are provided, including a thorough investigation of appropriate initial and boundary conditions. We connect our formalism with numerous other approaches in the literature. Some implementation details for numerical code are provided. We include animations of simulated primordial black hole formation as supplemental material.

  10. Probing the primordial universe with gravitational waves detectors

    Science.gov (United States)

    Wang, Yu-Tong; Cai, Yong; Liu, Zhi-Guo; Piao, Yun-Song

    2017-01-01

    The spectrum of primordial gravitational waves (GWs), especially its tilt nT, carries significant information about the primordial universe. Combining recent aLIGO and Planck2015+BK14 data, we find that the current limit is nT=0.016+0.614‑0.989 at 95% C.L. We also estimate the impacts of Einstein Telescope and LISA on constraining nT. Moreover, based on the effective field theory of cosmological perturbations, we make an attempt to confront some models of early universe scenarios, which produce blue-tilted GWs spectrum (nT>0), with the corresponding datasets.

  11. Evolution of Primordial Magnetic Fields: From Generation Till Today

    CERN Document Server

    Kahniashvili, Tina; Tevzadze, Alexander G

    2015-01-01

    In this presentation we summarize our previous results concerning the evolution of primordial magnetic fields with and without helicity during the expansion of the Universe. We address different magnetogenesis scenarios such as inflation, electroweak and QCD phase transitions magnetogenesis. A high Reynolds number in the early Universe ensures strong coupling between magnetic field and fluid motions. After generation the subsequent dynamics of the magnetic field is governed by decaying hydromagnetic turbulence. We claim that primordial magnetic fields can be considered as a seeds for observed magnetic fields in galaxies and clusters. Magnetic field strength bounds obtained in our analysis are consistent with the upper and lower limits of extragalactic magnetic fields.

  12. Stem cell factor and c-Kit in human primordial germ cells and fetal ovaries

    DEFF Research Database (Denmark)

    Høyer, Poul Erik; Byskov, Anne Grete; Møllgård, Kjeld

    2005-01-01

    Prenatal ovary (human), Primordial germ cells, Folliculogenesis, c-Kit, Stem cell factor, immunohistochemistry......Prenatal ovary (human), Primordial germ cells, Folliculogenesis, c-Kit, Stem cell factor, immunohistochemistry...

  13. Chromosomal Abnormalities and Putative Susceptibility Genes in Autism Spectrum Disorders

    DEFF Research Database (Denmark)

    Nielsen, Mette Gilling

    Autism spectrum disorders (ASDs) is a heterogeneous group of neurodevelopmental disorders with a significant genetic component as shown by family and twin studies. However, only a few genes have repeatedly been shown to be involved in the development of ASDs. The aim of this study has been...... to identify possible ASD susceptibility genes. Genome screens in ASD patients suggest possible susceptibility gene regions on almost every chromosome. We identified four ASD patients with chromosomal rearrangements, two of which were familial rearrangements involving one of these putative susceptibility gene......) was performed for all four patients. By combination of these methods we identified several putative susceptibility genes for ASDs. Expression patterns were established for several of these genes by Quantitative PCR (Q-PCR) or in situ hybridization and one gene was sequenced in 157 ASD patients. Our results...

  14. B-Pol: Detecting Primordial Gravitational Waves Generated During Inflation

    CERN Document Server

    de Bernardis, Paolo; Burigana, Carlo; Piccirillo, Lucio

    2008-01-01

    B-Pol is a medium-class space mission aimed at detecting the primordial gravitational waves generated during inflation through high accuracy measurements of the Cosmic Microwave Background (CMB) polarization. We discuss the scientific background, feasibility of the experiment, and implementation developed in response to the ESA Cosmic Vision 2015-2025 Call for Proposals.

  15. The polytropic equation of state of primordial gas clouds

    NARCIS (Netherlands)

    Spaans, M; Silk, J

    2005-01-01

    The polytropic equation of state (EOS) of primordial gas clouds with modest enrichment is computed, motivated by the recent observations of very Fe-deficient stars, [Fe/H] similar to 10(-3.5) to 10(-5), such as HE 0107 -5240 and CS 29498-043. These stars are overabundant, relative to Fe, in C and O.

  16. The cooling of shock-compressed primordial gas

    CERN Document Server

    Johnson, J L; Johnson, Jarrett L.; Bromm, Volker

    2006-01-01

    We find that at redshifts z > 10, HD line cooling allows strongly-shocked primordial gas to cool to the temperature of the cosmic microwave background (CMB). This temperature is the minimum value attainable via radiative cooling. Provided that the abundance of HD, normalized to the total number density, exceeds a critical level of ~ 10^{-8}, the CMB temperature floor is reached in a time which is short compared to the Hubble time. We estimate the characteristic masses of stars formed out of shocked primordial gas in the wake of the first supernovae, and resulting from the mergers of dark matter haloes during hierarchical structure formation to be ~ 10 M_{solar}. In addition, we show that cooling by HD enables the primordial gas in relic H II regions to cool to temperatures considerably lower than those reached via H_2 cooling alone. We confirm that HD cooling is unimportant in cases where the primordial gas does not go through an ionized phase, as in the formation process of the very first stars in z ~ 20 min...

  17. Black Hole Formation in Primordial Galaxies : Chemical and Radiative Conditions

    NARCIS (Netherlands)

    Schleicher, Dominik R. G.; Spaans, Marco; Glover, Simon C. O.

    2010-01-01

    In massive primordial galaxies, the gas may directly collapse and form a single central massive object if cooling is suppressed. H(2) line cooling can be suppressed in the presence of a strong soft-ultraviolet radiation field, but the role played by other cooling mechanisms is less clear. In optical

  18. Chameleon-Photon Mixing in a Primordial Magnetic Field

    CERN Document Server

    Schelpe, Camilla A O

    2010-01-01

    We consider the non-resonant mixing between photons and scalar axion-like particles (ALPs) in a primordial magnetic field, with specific reference to the chameleon scalar field model. This mixing would affect the intensity and polarization state of the cosmic microwave background (CMB) radiation. We find that the average modification to the CMB polarization modes is negligible. However the average modification to the CMB intensity spectrum is more significant and we compare this to high precision measurements of the CMB monopole made by the far infrared absolute spectrophotometer (FIRAS) on board the COBE satellite. The resulting 95% confidence limit on the scalar-photon conversion probability in the primordial field (at 100 GHz) is P < 2.6x10^{-2}. This corresponds to a degenerate constraint on the photon-scalar coupling strength, g, and the magnitude of the primordial magnetic field. Taking the 95% confidence upper bound on the strength of the primordial magnetic field found by Kahniashvili et al., this ...

  19. Renal tubular leakage complicating microcephalic osteodysplastic primordial dwarfism.

    Science.gov (United States)

    Eason, J; Hall, C M; Trounce, J Q

    1995-01-01

    We describe a male infant with phenotypic and radiological features of microcephalic osteodysplastic primordial dwarfism type I/III. He showed severe osteoporosis and biochemical derangement owing to renal tubular leakage, which has not previously been reported in this condition. He died aged 5 months. Images PMID:7783178

  20. The destruction of cosmological minihalos by primordial supernovae

    NARCIS (Netherlands)

    Whalen, D.; van Veelen, B.; O'Shea, B.W.; Norman, M.L.

    2008-01-01

    We present numerical simulations of primordial supernovae in cosmological minihalos at z ~ 20. We consider Type II supernovae, hypernovae, and pair instability supernovae (PISN) in halos from 6.9 × 105 to 1.2 × 107 M, those in which Population III stars are expected to form via H2 cooling. Our simul

  1. The primordial nucleus of comet 67P/Churyumov-Gerasimenko

    Science.gov (United States)

    Davidsson, B. J. R.; Sierks, H.; Güttler, C.; Marzari, F.; Pajola, M.; Rickman, H.; A'Hearn, M. F.; Auger, A.-T.; El-Maarry, M. R.; Fornasier, S.; Gutiérrez, P. J.; Keller, H. U.; Massironi, M.; Snodgrass, C.; Vincent, J.-B.; Barbieri, C.; Lamy, P. L.; Rodrigo, R.; Koschny, D.; Barucci, M. A.; Bertaux, J.-L.; Bertini, I.; Cremonese, G.; Da Deppo, V.; Debei, S.; De Cecco, M.; Feller, C.; Fulle, M.; Groussin, O.; Hviid, S. F.; Höfner, S.; Ip, W.-H.; Jorda, L.; Knollenberg, J.; Kovacs, G.; Kramm, J.-R.; Kührt, E.; Küppers, M.; La Forgia, F.; Lara, L. M.; Lazzarin, M.; Lopez Moreno, J. J.; Moissl-Fraund, R.; Mottola, S.; Naletto, G.; Oklay, N.; Thomas, N.; Tubiana, C.

    2016-07-01

    Context. We investigate the formation and evolution of comet nuclei and other trans-Neptunian objects (TNOs) in the solar nebula and primordial disk prior to the giant planet orbit instability foreseen by the Nice model. Aims: Our goal is to determine whether most observed comet nuclei are primordial rubble-pile survivors that formed in the solar nebula and young primordial disk or collisional rubble piles formed later in the aftermath of catastrophic disruptions of larger parent bodies. We also propose a concurrent comet and TNO formation scenario that is consistent with observations. Methods: We used observations of comet 67P/Churyumov-Gerasimenko by the ESA Rosetta spacecraft, particularly by the OSIRIS camera system, combined with data from the NASA Stardust sample-return mission to comet 81P/Wild 2 and from meteoritics; we also used existing observations from ground or from spacecraft of irregular satellites of the giant planets, Centaurs, and TNOs. We performed modeling of thermophysics, hydrostatics, orbit evolution, and collision physics. Results: We find that thermal processing due to short-lived radionuclides, combined with collisional processing during accretion in the primordial disk, creates a population of medium-sized bodies that are comparably dense, compacted, strong, heavily depleted in supervolatiles like CO and CO2; they contain little to no amorphous water ice, and have experienced extensive metasomatism and aqueous alteration due to liquid water. Irregular satellites Phoebe and Himalia are potential representatives of this population. Collisional rubble piles inherit these properties from their parents. Contrarily, comet nuclei have low density, high porosity, weak strength, are rich in supervolatiles, may contain amorphous water ice, and do not display convincing evidence of in situ metasomatism or aqueous alteration. We outline a comet formation scenario that starts in the solar nebula and ends in the primordial disk, that reproduces these

  2. POLARBEAR constraints on cosmic birefringence and primordial magnetic fields

    Science.gov (United States)

    Ade, Peter A. R.; Arnold, Kam; Atlas, Matt; Baccigalupi, Carlo; Barron, Darcy; Boettger, David; Borrill, Julian; Chapman, Scott; Chinone, Yuji; Cukierman, Ari; Dobbs, Matt; Ducout, Anne; Dunner, Rolando; Elleflot, Tucker; Errard, Josquin; Fabbian, Giulio; Feeney, Stephen; Feng, Chang; Gilbert, Adam; Goeckner-Wald, Neil; Groh, John; Hall, Grantland; Halverson, Nils W.; Hasegawa, Masaya; Hattori, Kaori; Hazumi, Masashi; Hill, Charles; Holzapfel, William L.; Hori, Yasuto; Howe, Logan; Inoue, Yuki; Jaehnig, Gregory C.; Jaffe, Andrew H.; Jeong, Oliver; Katayama, Nobuhiko; Kaufman, Jonathan P.; Keating, Brian; Kermish, Zigmund; Keskitalo, Reijo; Kisner, Theodore; Kusaka, Akito; Le Jeune, Maude; Lee, Adrian T.; Leitch, Erik M.; Leon, David; Li, Yun; Linder, Eric; Lowry, Lindsay; Matsuda, Frederick; Matsumura, Tomotake; Miller, Nathan; Montgomery, Josh; Myers, Michael J.; Navaroli, Martin; Nishino, Haruki; Okamura, Takahiro; Paar, Hans; Peloton, Julien; Pogosian, Levon; Poletti, Davide; Puglisi, Giuseppe; Raum, Christopher; Rebeiz, Gabriel; Reichardt, Christian L.; Richards, Paul L.; Ross, Colin; Rotermund, Kaja M.; Schenck, David E.; Sherwin, Blake D.; Shimon, Meir; Shirley, Ian; Siritanasak, Praween; Smecher, Graeme; Stebor, Nathan; Steinbach, Bryan; Suzuki, Aritoki; Suzuki, Jun-ichi; Tajima, Osamu; Takakura, Satoru; Tikhomirov, Alexei; Tomaru, Takayuki; Whitehorn, Nathan; Wilson, Brandon; Yadav, Amit; Zahn, Alex; Zahn, Oliver; Polarbear Collaboration

    2015-12-01

    We constrain anisotropic cosmic birefringence using four-point correlations of even-parity E -mode and odd-parity B -mode polarization in the cosmic microwave background measurements made by the POLARization of the Background Radiation (POLARBEAR) experiment in its first season of observations. We find that the anisotropic cosmic birefringence signal from any parity-violating processes is consistent with zero. The Faraday rotation from anisotropic cosmic birefringence can be compared with the equivalent quantity generated by primordial magnetic fields if they existed. The POLARBEAR nondetection translates into a 95% confidence level (C.L.) upper limit of 93 nanogauss (nG) on the amplitude of an equivalent primordial magnetic field inclusive of systematic uncertainties. This four-point correlation constraint on Faraday rotation is about 15 times tighter than the upper limit of 1380 nG inferred from constraining the contribution of Faraday rotation to two-point correlations of B -modes measured by Planck in 2015. Metric perturbations sourced by primordial magnetic fields would also contribute to the B -mode power spectrum. Using the POLARBEAR measurements of the B -mode power spectrum (two-point correlation), we set a 95% C.L. upper limit of 3.9 nG on primordial magnetic fields assuming a flat prior on the field amplitude. This limit is comparable to what was found in the Planck 2015 two-point correlation analysis with both temperature and polarization. We perform a set of systematic error tests and find no evidence for contamination. This work marks the first time that anisotropic cosmic birefringence or primordial magnetic fields have been constrained from the ground at subdegree scales.

  3. Selections from 2016: Primordial Black Holes as Dark Matter

    Science.gov (United States)

    Kohler, Susanna

    2016-12-01

    Editors note:In these last two weeks of 2016, well be looking at a few selections that we havent yet discussed on AAS Nova from among the most-downloaded paperspublished in AAS journals this year. The usual posting schedule will resume after the AAS winter meeting.LIGO Gravitational Wave Detection, Primordial Black Holes, and the Near-IR Cosmic Infrared Background AnisotropiesPublished May2016Main takeaway:A study by Alexander Kashlinsky (NASA Goddard SFC) proposes that the cold dark matter that makes up the majority of the universes matter may be made of black holes. These black holes, Kashlinsky suggests, are primordial: they collapsed directly from dense regions of the universe soon after the Big Bang.Why its interesting:This model would simultaneously explain several observations. In particular, we see similarities in patterns between the cosmic infrared and X-ray backgrounds. This would make sense if accretion onto primordial black holes in halos produced the X-ray background in the same regions where the first stars also formed, producing the infrared background.What this means for current events:In Kashlinskys model, primordial black holes would occasionally form binary pairs and eventually spiral in and merge. The release of energy from such an event would then be observable by gravitational-wave detectors. Could the gravitational-wave signal that LIGO detected last year have been two primordial black holes merging? More observations will be needed to find out.CitationA. Kashlinsky 2016 ApJL 823 L25. doi:10.3847/2041-8205/823/2/L25

  4. From primordial germ cells to primordial follicles: a review and visual representation of early ovarian development in mice.

    Science.gov (United States)

    Wear, Hannah M; McPike, Matthew J; Watanabe, Karen H

    2016-06-21

    Normal development of reproductive organs is crucial for successful reproduction. In mice the early ovarian developmental process occurs during the embryonic and postnatal period and is regulated through a series of molecular signaling events. Early ovarian development in mice is a seventeen-day process that begins with the rise of six primordial germ cells on embryonic day five (E5) and ends with the formation of primordial follicles on postnatal day two (P2). We reviewed the current literature and created a visual representation of early ovarian development that depicts the important molecular events and associated phenotypic outcomes based on primary data. The visual representation shows the timeline of key signaling interactions and regulation of protein expression in different cells involved in ovarian development. The major developmental events were divided into five phases: 1) origin of germ cells and maintenance of pluripotency; 2) primordial germ cell migration; 3) sex differentiation; 4) formation of germ cell nests; and 5) germ cell nest breakdown and primordial follicle formation. This review and visual representation provide a summary of the current scientific understanding of the key regulation and signaling during ovarian development and highlights areas needing further study. The visual representation can be used as an educational resource to link molecular events with phenotypic outcomes; serves as a tool to generate new hypotheses and predictions of adverse reproductive outcomes due to perturbations at the molecular and cellular levels; and provides a comprehendible foundation for computational model development and hypothesis testing.

  5. Microcephalic osteodysplastic primordial dwarfism type II (MOPD II) with multiple vascular complications misdiagnosed as Dubowitz syndrome.

    Science.gov (United States)

    Dieks, Jana-Katharina; Baumer, Alessandra; Wilichowski, Ekkehard; Rauch, Anita; Sigler, Matthias

    2014-09-01

    To date, the genetic basis of Dubowitz syndrome (short stature, microcephaly, facial abnormalities, eczema) is unknown and vascular complications are not known to be associated with this syndrome. In microcephalic osteodysplastic primordial dwarfism type II (MOPD II; disproportionate short statue, microcephaly, facial abnormalities), however, cerebral aneurysms and other vascular abnormalities are frequent complications. MOPD II is a genetic disorder caused by mutations in the pericentrin (PCNT) gene (21q22). We report on a patient who came to our attention as a 22-year-old with subarachnoid bleeding due to a ruptured cranial aneurysm. Until then, the patient was thought and published to have Dubowitz syndrome; previously, he was treated with coronary bypass surgery for extensive coronary angiopathy. Consecutive genetic testing revealed MOPD II. After clinical stabilization, the patient was discharged to a specialized rehabilitation center where he died due to re-rupture of a cranial aneurysm. In patients with short stature-especially when clinical features are accompanied by vascular complications-MOPD II should be considered as a differential diagnosis leading to consecutive genetic testing. After detection of mutations in the PCNT gene, a full vascular status including cerebral imaging and cardiac evaluation needs to be determined in order to analyze vascular abnormalities and initiate prophylactic treatment.

  6. Germline Gene Editing in Chickens by Efficient CRISPR-Mediated Homologous Recombination in Primordial Germ Cells.

    Science.gov (United States)

    Dimitrov, Lazar; Pedersen, Darlene; Ching, Kathryn H; Yi, Henry; Collarini, Ellen J; Izquierdo, Shelley; van de Lavoir, Marie-Cecile; Leighton, Philip A

    2016-01-01

    The CRISPR/Cas9 system has been applied in a large number of animal and plant species for genome editing. In chickens, CRISPR has been used to knockout genes in somatic tissues, but no CRISPR-mediated germline modification has yet been reported. Here we use CRISPR to target the chicken immunoglobulin heavy chain locus in primordial germ cells (PGCs) to produce transgenic progeny. Guide RNAs were co-transfected with a donor vector for homology-directed repair of the double-strand break, and clonal populations were selected. All of the resulting drug-resistant clones contained the correct targeting event. The targeted cells gave rise to healthy progeny containing the CRISPR-targeted locus. The results show that gene-edited chickens can be obtained by modifying PGCs in vitro with the CRISPR/Cas9 system, opening up many potential applications for efficient genetic modification in birds.

  7. Multiple intracranial aneurysms and moyamoya disease associated with microcephalic osteodysplastic primordial dwarfism type II: surgical considerations.

    Science.gov (United States)

    Waldron, James S; Hetts, Steven W; Armstrong-Wells, Jennifer; Dowd, Christopher F; Fullerton, Heather J; Gupta, Nalin; Lawton, Michael T

    2009-11-01

    Microcephalic osteodysplastic primordial dwarfism type II (MOPD II) is a rare genetic syndrome characterized by extremely small stature and microcephaly, and is associated in 25% of patients with intracranial aneurysms and moyamoya disease. Although aneurysmal subarachnoid hemorrhage and stroke are leading causes of morbidity and death in these patients, MOPD II is rarely examined in the neurosurgical literature. The authors report their experience with 3 patients who presented with MOPD II, which includes a patient with 8 aneurysms (the most aneurysms reported in the literature), and the first report of a patient with both moyamoya disease and multiple aneurysms. The poor natural history of these lesions indicates aggressive microsurgical and/or endovascular therapy. Microsurgery, whether for aneurysm clip placement or extracranial-intracranial bypass, is challenging due to tight surgical corridors and diminutive arteries in these patients, but is technically feasible and strongly indicated when multiple aneurysms must be treated or cerebral revascularization is needed.

  8. TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism.

    Science.gov (United States)

    Harley, Margaret E; Murina, Olga; Leitch, Andrea; Higgs, Martin R; Bicknell, Louise S; Yigit, Gökhan; Blackford, Andrew N; Zlatanou, Anastasia; Mackenzie, Karen J; Reddy, Kaalak; Halachev, Mihail; McGlasson, Sarah; Reijns, Martin A M; Fluteau, Adeline; Martin, Carol-Anne; Sabbioneda, Simone; Elcioglu, Nursel H; Altmüller, Janine; Thiele, Holger; Greenhalgh, Lynn; Chessa, Luciana; Maghnie, Mohamad; Salim, Mahmoud; Bober, Michael B; Nürnberg, Peter; Jackson, Stephen P; Hurles, Matthew E; Wollnik, Bernd; Stewart, Grant S; Jackson, Andrew P

    2016-01-01

    DNA lesions encountered by replicative polymerases threaten genome stability and cell cycle progression. Here we report the identification of mutations in TRAIP, encoding an E3 RING ubiquitin ligase, in patients with microcephalic primordial dwarfism. We establish that TRAIP relocalizes to sites of DNA damage, where it is required for optimal phosphorylation of H2AX and RPA2 during S-phase in response to ultraviolet (UV) irradiation, as well as fork progression through UV-induced DNA lesions. TRAIP is necessary for efficient cell cycle progression and mutations in TRAIP therefore limit cellular proliferation, providing a potential mechanism for microcephaly and dwarfism phenotypes. Human genetics thus identifies TRAIP as a component of the DNA damage response to replication-blocking DNA lesions.

  9. Two classes of ovarian primordial follicles exhibit distinct developmental dynamics and physiological functions.

    Science.gov (United States)

    Zheng, Wenjing; Zhang, Hua; Gorre, Nagaraju; Risal, Sanjiv; Shen, Yan; Liu, Kui

    2014-02-15

    In the mammalian ovary, progressive activation of primordial follicles serves as the source of fertilizable ova, and disorders in the development of primordial follicles lead to various ovarian diseases. However, very little is known about the developmental dynamics of primordial follicles under physiological conditions, and the fates of distinct populations of primordial follicles also remain unclear. In this study, by generating the Foxl2-CreER(T2) and Sohlh1-CreER(T2) inducible mouse models, we have specifically labeled and traced the in vivo development of two classes of primordial follicles, the first wave of simultaneously activated follicles after birth and the primordial follicles that are gradually activated in adulthood. Our results show that the first wave of follicles exists in the ovaries for ∼3 months and contributes to the onset of puberty and to early fertility. The primordial follicles at the ovarian cortex gradually replace the first wave of follicles and dominate the ovary after 3 months of age, providing fertility until the end of reproductive life. Moreover, by tracing the time periods needed for primordial follicles to reach various advanced stages in vivo, we were able to determine the exact developmental dynamics of the two classes of primordial follicles. We have now revealed the lifelong developmental dynamics of ovarian primordial follicles under physiological conditions and have clearly shown that two classes of primordial follicles follow distinct, age-dependent developmental paths and play different roles in the mammalian reproductive lifespan.

  10. Mutation in WDR4 impairs tRNA m(7)G46 methylation and causes a distinct form of microcephalic primordial dwarfism.

    Science.gov (United States)

    Shaheen, Ranad; Abdel-Salam, Ghada M H; Guy, Michael P; Alomar, Rana; Abdel-Hamid, Mohamed S; Afifi, Hanan H; Ismail, Samira I; Emam, Bayoumi A; Phizicky, Eric M; Alkuraya, Fowzan S

    2015-09-28

    Primordial dwarfism is a state of extreme prenatal and postnatal growth deficiency, and is characterized by marked clinical and genetic heterogeneity. Two presumably unrelated consanguineous families presented with an apparently novel form of primordial dwarfism in which severe growth deficiency is accompanied by distinct facial dysmorphism, brain malformation (microcephaly, agenesis of corpus callosum, and simplified gyration), and severe encephalopathy with seizures. Combined autozygome/exome analysis revealed a novel missense mutation in WDR4 as the likely causal variant. WDR4 is the human ortholog of the yeast Trm82, an essential component of the Trm8/Trm82 holoenzyme that effects a highly conserved and specific (m(7)G46) methylation of tRNA. The human mutation and the corresponding yeast mutation result in a significant reduction of m(7)G46 methylation of specific tRNA species, which provides a potential mechanism for primordial dwarfism associated with this lesion, since reduced m(7)G46 modification causes a growth deficiency phenotype in yeast. Our study expands the number of biological pathways underlying primordial dwarfism and adds to a growing list of human diseases linked to abnormal tRNA modification.

  11. Imprints of a Primordial Preferred Direction on the Microwave Background

    CERN Document Server

    Ackerman, L; Wise, M B; Ackerman, Lotty; Carroll, Sean M.; Wise, Mark B.

    2007-01-01

    Rotational invariance is a well-established feature of low-energy physics. Violations of this symmetry must be extremely small today, but could have been larger in earlier epochs. In this paper we examine the consequences of a small breaking of rotational invariance during the inflationary era when the primordial density fluctuations were generated. Assuming that a fixed-norm vector picked out a preferred direction during the inflationary era, we explore the imprint it would leave on the cosmic microwave background anisotropy, and provide explicit formulas for the expected amplitudes $$ of the spherical-harmonic coefficients. We suggest that it is natural to expect that the imprint on the primordial power spectrum of a preferred spatial direction is approximately scale-invariant, and examine a simple model in which this is true.

  12. An MCMC determination of the primordial helium abundance

    CERN Document Server

    Aver, Erik; Skillman, Evan D

    2011-01-01

    Spectroscopic observations of the chemical abundances in metal-poor H II regions provide an independent method for estimating the primordial helium abundance. H II regions are described by several physical parameters such as electron density, electron temperature, and reddening, in addition to y, the ratio of helium to hydrogen. It had been customary to estimate or determine self-consistently these parameters to calculate y. Frequentist analyses of the parameter space have been shown to be successful in these determinations, and Markov Chain Monte Carlo (MCMC) techniques have proven to be very efficient in sampling this parameter space. Nevertheless, accurate determination of the primordial helium abundance from observations of H II regions is constrained by both systematic and statistical uncertainties. In an attempt to better reduce the latter, and better characterize the former, we apply MCMC methods to the large dataset recently compiled by Izotov, Thuan, & Stasinska (2007). To improve the reliability...

  13. Primordial Perturbations in Einstein-Aether and BPSH Theories

    CERN Document Server

    Armendariz-Picon, Cristian; Garriga, Jaume

    2010-01-01

    We study the primordial perturbations generated during a stage of single-field inflation in Einstein-aether theories. Quantum fluctuations of the inflaton and aether fields seed long wavelength adiabatic and isocurvature scalar perturbations, as well as transverse vector perturbations. Geometrically, the isocurvature mode is the potential for the velocity field of the aether with respect to matter. For a certain range of parameters, this mode may lead to a sizable random velocity of the aether within the observable universe. The adiabatic mode corresponds to curvature perturbations of co-moving slices (where matter is at rest). In contrast with the standard case, it has a non-vanishing anisotropic stress on large scales. Scalar and vector perturbations may leave significant imprints on the cosmic microwave background. We calculate their primordial spectra, analyze their contributions to the temperature anisotropies, and formulate some of the phenomenological constraints that follow from observations. These ma...

  14. Testing the Standard Model with the Primordial Inflation Explorer

    Science.gov (United States)

    Kogut, Alan J.

    2011-01-01

    The Primordial Inflation Explorer is an Explorer-class mission to measure the gravity-wave signature of primordial inflation through its distinctive imprint on the linear polarization of the cosmic microwave background. PIXIE uses an innovative optical design to achieve background-limited sensitivity in 400 spectral channels spanning 2.5 decades in frequency from 30 GHz to 6 THz (1 cm to 50 micron wavelength). The principal science goal is the detection and characterization of linear polarization from an inflationary epoch in the early universe, with tensor-to-scalar ratio r < 10A{-3) at 5 standard deviations. The rich PIXIE data set will also constrain physical processes ranging from Big Bang cosmology to the nature of the first stars to physical conditions within the interstellar medium of the Galaxy. I describe the PIXIE instrument and mission architecture needed to detect the inflationary signature using only 4 semiconductor bolometers.

  15. High-order Primordial Perturbations with Quantum Gravitational Effects

    CERN Document Server

    Zhu, Tao; Kirsten, Klaus; Cleaver, Gerald; Sheng, Qin

    2016-01-01

    In this paper, we provide a systematic investigation of high-order primordial perturbations with nonlinear dispersion relations due to quantum gravitational effects in the framework of {\\em uniform asymptotic approximations}. Because of these effects, the equation of motion of the mode function in general has multiple-turning points. After obtaining analytically approximated solutions in different regions, associated with different types of turning points, to any order, we match them to the third one. To this order the errors are less than $0.15\\%$. General expressions of the power spectra of the primordial tensor and scalar perturbations are derived explicitly. We also investigate effects of back-reactions of the quantum gravitational corrections, and make sure that inflation lasts long enough in order to solve underlying problems, such as flatness, horizon and monopole. Various features of the spectra that are observationally relevant are investigated. In particular, under a moderate assumption about the en...

  16. Microcephalic Osteodysplastic Primordial Dwarfism, Type II: a Clinical Review.

    Science.gov (United States)

    Bober, Michael B; Jackson, Andrew P

    2017-04-01

    This review will provide an overview of the microcephalic primordial dwarfism (MPD) class of disorders and provide the reader comprehensive clinical review with suggested care guidelines for patients with microcephalic osteodysplastic primordial dwarfism, type II (MOPDII). Over the last 15 years, significant strides have been made in the diagnosis, natural history, and management of MOPDII. MOPDII is the most common and well described form of MPD. The classic features of the MPD group are severe pre- and postnatal growth retardation, with marked microcephaly. In addition to these features, individuals with MOPDII have characteristic facies, skeletal dysplasia, abnormal dentition, and an increased risk for cerebrovascular disease and insulin resistance. Biallelic loss-of-function mutations in the pericentrin gene cause MOPDII, which is inherited in an autosomal recessive manner.

  17. Inflation, Reionization, and All That: The Primordial Inflation Explorer

    Science.gov (United States)

    Kogut, Alan J.

    2012-01-01

    The Primordial Inflation Explorer is an Explorer-class mission to measure the gravity-wave signature of primordial inflation through its distinctive imprint on the linear polarization of the cosmic microwave background. PIXIE uses an innovative optical design to achieve background-limited sensitivity in 400 spectral channels spanning 2.5 decades in frequency from 30 GHz to 6 THz (1 cm to 50 micron wavelength). The principal science goal is the detection and characterization of linear polarization from an inflationary epoch in the early universe, with tensor-to-scalar ratio r < 10(exp -3) at 5 standard deviations. The rich PIXIE data set will also constrain physical processes ranging from Big Bang cosmology to the nature of the first stars to physical conditions within the interstellar medium of the Galaxy. I describe the PIXIE instrument and mission architecture needed to detect the inflationary signature using only 4 semiconductor bolometers.

  18. Primordial Black Holes as Dark Matter: All or Nothing

    CERN Document Server

    Lacki, Brian C

    2010-01-01

    Primordial black holes (PBHs) are expected to accrete particle dark matter around them to form primordially-laid ultracompact minihalos (PLUMs), if the PBHs themselves are not most of the dark matter. We show that if most dark matter is a thermal relic, then the inner regions of PLUMs around PBHs are highly luminous sources of annihilation products. Flux constraints on gamma rays and neutrinos set strong abundance limits, improving previous limits by orders of magnitude. Assuming enough particle dark matter exists to form PLUMs (if PBHs do not compose all of the dark matter), we find that Omega_PBH <~ 10^-4 (for m_DM c^2 ~ 100 GeV) for a vast range in PBH mass, 10^-18 M_sun to 1000 M_sun.

  19. Cosmological long-wavelength solutions and primordial black hole formation

    CERN Document Server

    Harada, Tomohiro; Nakama, Tomohiro; Koga, Yasutaka

    2015-01-01

    We construct cosmological long-wavelength solutions without symmetry in general gauge conditions compatible with the long-wavelength scheme. We then specify the relationship among the solutions in different time slicings. Nonspherical long-wavelength solutions are particularly important for primordial structure formation in the epoch of soft equations of state. Applying this framework to spherical symmetry, we show the equivalence between long-wavelength solutions in the constant mean curvature slicing and asymptotic quasi-homogeneous solutions in the comoving slicing. We derive the correspondence relation and compare the results of numerical simulations of primordial black hole (PBH) formation. In terms of $\\tilde{\\delta}_{c}$, the value which the averaged density perturbation at threshold in the comoving slicing would take at horizon entry in the first-order long-wavelength expansion, we find that the sharper the transition from the overdense region to the FRW universe is, the larger the $\\tilde{\\delta}_{c}...

  20. The primordial helium abundance and the number of neutrino families

    CERN Document Server

    Peimbert, Antonio; Luridiana, Valentina

    2016-01-01

    Based on observations of HII regions and the new computations of the recombination coefficients of the He I lines by Porter et al. (2013) we obtain a primordial helium abundance by mass of $Y_P = 0.2446\\pm0.0029$. We consider thirteen sources of error for the $Y_P$ determination, some of them are mainly due to systematic effects, while the rest are mainly due to statistical effects. We compare our results with other determinations of $Y_P$ present in the literature. Combining our $Y_P$ value with computations of primordial nucleosynthesis we find a number of neutrino species $N_{eff} = 2.90\\pm0.22$, and a neutron mean life $\\tau_{\

  1. Constraints on the Variation of G from Primordial Nucleosynthesis

    CERN Document Server

    Clifton, T; Barrow, J D

    2005-01-01

    We study here the effect of a varying G on the evolution of the early universe and, in particular, on primordial nucleosynthesis. This variation of G is modelled using the Brans-Dicke theory as well as a more general class of scalar-tensor theories. Modified nucleosynthesis codes are used to investigate this effect and the results obtained are used to constrain the parameters of the theories. We extend previous studies of primordial nucleosynthesis in scalar-tensor theories by including effects which can cause a slow variation of G during radiation domination and by including a late-time accelerating phase to the universe's history. We include a brief discussion on the epoch of matter-radiation equality in Brans-Dicke theory, which is also of interest for determining the positions of the CMB power spectrum peaks.

  2. Mutations in XRCC4 cause primordial dwarfism without causing immunodeficiency.

    Science.gov (United States)

    Saito, Shinta; Kurosawa, Aya; Adachi, Noritaka

    2016-08-01

    In successive reports from 2014 to 2015, X-ray repair cross-complementing protein 4 (XRCC4) has been identified as a novel causative gene of primordial dwarfism. XRCC4 is indispensable for non-homologous end joining (NHEJ), the major pathway for repairing DNA double-strand breaks. As NHEJ is essential for V(D)J recombination during lymphocyte development, it is generally believed that abnormalities in XRCC4 cause severe combined immunodeficiency. Contrary to expectations, however, no overt immunodeficiency has been observed in patients with primordial dwarfism harboring XRCC4 mutations. Here, we describe the various XRCC4 mutations that lead to disease and discuss their impact on NHEJ and V(D)J recombination.

  3. Non-standard primordial fluctuations and nongaussianity in string inflation

    CERN Document Server

    Burgess, C P; Gomez-Reino, M; Quevedo, F; Tasinato, G; Zavala, I

    2010-01-01

    Inflationary scenarios in string theory often involve a large number of light scalar fields, whose presence can enrich the post-inflationary evolution of primordial fluctuations generated during the inflationary epoch. We provide a simple example of such post-inflationary processing within an explicit string-inflationary construction, using a Kahler modulus as the inflaton within the framework of LARGE Volume Type-IIB string flux compactifications. We argue that inflationary models within this broad category often have a selection of scalars that are light enough to be cosmologically relevant, whose contributions to the primordial fluctuation spectrum can compete with those generated in the standard way by the inflaton. These models consequently often predict nongaussianity at a level, f_NL ~ O(10), potentially observable by the Planck satellite, with a bi-spectrum maximized by triangles with squeezed shape in a string realisation of the curvaton scenario. We argue that the observation of such a signal would ...

  4. Primordial non-Gaussianities after Planck 2015: an introductory review

    CERN Document Server

    Renaux-Petel, Sébastien

    2015-01-01

    Deviations from Gaussian statistics of the cosmological density fluctuations, so-called primordial non-Gaussianities (NG), are one of the most informative fingerprints of the origin of structures in the universe. Indeed, they can probe physics at energy scales inaccessible to laboratory experiments, and are sensitive to the interactions of the field(s) that generated the primordial fluctuations, contrary to the Gaussian linear theory. As a result, they can discriminate between inflationary models that are otherwise almost indistinguishable. In this short review, we explain how to compute the non-Gaussian properties in any inflationary scenario. We review the theoretical predictions of several important classes of models. We then describe the ways NG can be probed observationally, and we highlight the recent constraints from the Planck mission, as well as their implications. We finally identify well motivated theoretical targets for future experiments and discuss observational prospects.

  5. Forming a Primordial Star in a Relic HII Region

    CERN Document Server

    O'Shea, B W; Whalen, D; Norman, M L; Shea, Brian W. O'; Abel, Tom; Whalen, Dan; Norman, Michael L.

    2005-01-01

    There has been considerable theoretical debate over whether photoionization and supernova feedback from the first Population III stars facilitate or suppress the formation of the next generation of stars. We present results from an Eulerian adaptive mesh refinement simulation demonstrating the formation of a primordial star within a region ionized by an earlier nearby star. Despite the higher temperatures of the ionized gas and its flow out of the dark matter potential wells, this second star formed within 23 million years of its neighbor's death. The enhanced electron fraction within the HII region catalyzes rapid molecular hydrogen formation that leads to faster cooling in the subsequent star forming halos than in the first halos. This ``second generation'' primordial protostar has a much lower accretion rate because, unlike the first protostar, it forms in a rotationally supported disk of approximately 10-100 solar masses. In contrast to unpreprocessed regions, such configurations may allow binaries or mul...

  6. Could supermassive black holes be quintessential primordial black holes?

    CERN Document Server

    Bean, R; Bean, Rachel; Magueijo, Joao

    2002-01-01

    There is growing observational evidence for a population of supermassive black holes (SMBHs) in galactic bulges. We examine in detail the conditions under which these black holes must have originated from primordial black holes (PBHs). We consider the merging and accretion history experienced by SMBHs to find that, whereas it is possible that they were formed by purely astrophysical processes, this is unlikely and most probably a populations of primordial progenitors is necessary. We identify the mass distribution and comoving density of this population and then propose a cosmological scenario producing PBHs with the right properties. Although this is not essential we consider PBHs produced at the end of a period of inflation with a blue spectrum of fluctuations. We constrain the value of the spectral tilt in order to obtain the required PBH comoving density. We then assume that PBHs grow by accreting quintessence showing that their mass scales like the horizon mass while the quintessence field itself is scal...

  7. Ionization Front Instabilities in Primordial H II Regions

    CERN Document Server

    Whalen, Daniel

    2007-01-01

    Radiative cooling by metals in shocked gas mediates the formation of ionization front instabilities in the galaxy today that are responsible for a variety of phenomena in the interstellar medium, from the morphologies of nebulae to triggered star formation in molecular clouds. An important question in early reionization and chemical enrichment of the intergalactic medium is whether such instabilities arose in the H II regions of the first stars and primeval galaxies, which were devoid of metals. We present three-dimensional numerical simulations that reveal both shadow and thin-shell instabilities readily formed in primordial gas. We find that the hard UV spectra of Population III stars broadened primordial ionization fronts, causing H2 formation capable of inciting violent thin- shell instabilities in D-type fronts, even in the presence of intense Lyman-Werner flux. The high post- front gas temperatures associated with He ionization sustained and exacerbated shadow instabilities, unaided by molecular hydroge...

  8. Quantum-gravity phenomenology with primordial black holes

    CERN Document Server

    Vidotto, Francesca; Bolliet, Boris; Shutten, Marrit; Weimer, Celine

    2016-01-01

    Quantum gravity may allow black holes to tunnel into white holes. If so, the lifetime of a black hole could be shorter than the one given by Hawking evaporation, solving the information paradox. More interestingly, this could open to a new window for quantum-gravity phenomenology, in connection with the existence of primordial black holes. We discuss in particular the power of the associated explosion and the possibility to observe an astrophysical signal in the radio and in the gamma wavelengths.

  9. Tracing primordial protein evolution through structurally guided stepwise segment elongation.

    Science.gov (United States)

    Watanabe, Hideki; Yamasaki, Kazuhiko; Honda, Shinya

    2014-02-07

    The understanding of how primordial proteins emerged has been a fundamental and longstanding issue in biology and biochemistry. For a better understanding of primordial protein evolution, we synthesized an artificial protein on the basis of an evolutionary hypothesis, segment-based elongation starting from an autonomously foldable short peptide. A 10-residue protein, chignolin, the smallest foldable polypeptide ever reported, was used as a structural support to facilitate higher structural organization and gain-of-function in the development of an artificial protein. Repetitive cycles of segment elongation and subsequent phage display selection successfully produced a 25-residue protein, termed AF.2A1, with nanomolar affinity against the Fc region of immunoglobulin G. AF.2A1 shows exquisite molecular recognition ability such that it can distinguish conformational differences of the same molecule. The structure determined by NMR measurements demonstrated that AF.2A1 forms a globular protein-like conformation with the chignolin-derived β-hairpin and a tryptophan-mediated hydrophobic core. Using sequence analysis and a mutation study, we discovered that the structural organization and gain-of-function emerged from the vicinity of the chignolin segment, revealing that the structural support served as the core in both structural and functional development. Here, we propose an evolutionary model for primordial proteins in which a foldable segment serves as the evolving core to facilitate structural and functional evolution. This study provides insights into primordial protein evolution and also presents a novel methodology for designing small sized proteins useful for industrial and pharmaceutical applications.

  10. Primordial perturbations in tachyonic power-law inflation

    CERN Document Server

    de Souza, Rudinei C

    2013-01-01

    In this work we determine the power spectrum of the gravitational potential of the primordial fluctuations for an inflationary model whose \\emph{inflaton} is a non-canonical scalar field of the tachyon-type. The respective background field equations for an inverse-square potential produce a power-law inflation, and it is explicitly shown that for such a potential the power spectrum tends to be scale-independent for highly accelerated regimes in the inflationary expansion.

  11. Dark energy and dark matter from primordial QGP

    Energy Technology Data Exchange (ETDEWEB)

    Vaidya, Vaishali, E-mail: vaidvavaishali24@gmail.com; Upadhyaya, G. K., E-mail: gopalujiain@yahoo.co.in [School of Studies in Physics, Vikram University Ujjain (India)

    2015-07-31

    Coloured relics servived after hadronization might have given birth to dark matter and dark energy. Theoretical ideas to solve mystery of cosmic acceleration, its origin and its status with reference to recent past are of much interest and are being proposed by many workers. In the present paper, we present a critical review of work done to understand the earliest appearance of dark matter and dark energy in the scenario of primordial quark gluon plasma (QGP) phase after Big Bang.

  12. Noncommutative Geometry and the Primordial Dipolar Imaginary Power Spectrum

    CERN Document Server

    Jain, P

    2014-01-01

    We argue that an anisotropic dipolar imaginary primordial power spectrum is possible within the framework of noncommutative space-times. We show that such a spectrum provides a good description of the observed dipole modulation in CMBR data. We extract the corresponding power spectrum from data. The dipole modulation is related to the observed hemispherical anisotropy in CMBR data, which might represent the first signature of quantum gravity.

  13. Using Gravitational Waves to put limits on Primordial Magnetic Fields

    CERN Document Server

    Garrison, David

    2016-01-01

    We describe a technique for using simulated tensor perturbations in order to place upper limits on the intensity of magnetic fields in the early universe. As an example, we apply this technique to the beginning of primordial nucleosynthesis. We determined that any magnetic seed fields that existed before that time were still in the process of being amplified. In the future, we plan to apply this technique to a wider range of initial magnetic fields and cosmological epochs.

  14. Cosmological parameter estimation with free-form primordial power spectrum

    CERN Document Server

    Hazra, Dhiraj Kumar; Souradeep, Tarun

    2013-01-01

    Constraints on the main cosmological parameters using CMB or large scale structure data are usually based on power-law assumption of the primordial power spectrum (PPS). However, in the absence of a preferred model for the early universe, this raises a concern that current cosmological parameter estimates are strongly prejudiced by the assumed power-law form of PPS. In this paper, for the first time, we perform cosmological parameter estimation allowing the free form of the primordial spectrum. This is in fact the most general approach to estimate cosmological parameters without assuming any particular form for the primordial spectrum. We use direct reconstruction of the PPS for any point in the cosmological parameter space using recently modified Richardson-Lucy algorithm however other alternative reconstruction methods could be used for this purpose as well. We use WMAP 9 year data in our analysis considering CMB lensing effect and we report, for the first time, that the flat spatial universe with no cosmol...

  15. The Number of Supernovae From Primordial Stars in the Universe

    Energy Technology Data Exchange (ETDEWEB)

    Wise, J

    2004-12-15

    Recent simulations of the formation of the first luminous objects in the universe predict isolated very massive stars to form in dark matter halos with virial temperatures large enough to allow significant amounts of molecular hydrogen to form. We construct a semi-analytic model based on the Press-Schechter formalism and calibrate the minimum halos mass that may form a primordial star with the results from extensive adaptive mesh refinement simulations. The model also includes star formation in objects with virial temperatures in excess of ten thousand Kelvin. The free parameters are tuned to match the optical depth measurements by the WMAP satellite. The models explicitly includes the negative feedback of the destruction of molecular hydrogen by a soft UV background which is computed self-consistently. We predict high redshift supernova rates as one of the most promising tools to test the current scenario of primordial star formation. The supernova rate from primordial stars peaks at redshifts {approx}20. Using an analytic model for the luminosities of pair-instability supernovae we predict observable magnitudes and discuss possible observational strategies. Such supernovae would release enough metals corresponding to a uniform enrichment to a few hundred thousands of solar metalicity. If some of these stars produce gamma ray bursts our rates will be directly applicable to understanding the anticipated results from the SWIFT satellite. This study highlights the great potential for the James Webb space telescope in probing cosmic structure at redshifts greater than 20.

  16. Primordial magnetic field constraints from the end of reionization

    CERN Document Server

    Schleicher, Dominik R G

    2011-01-01

    Primordial magnetic fields generated in the early universe are subject of considerable investigation, and observational limits on their strength are required to constrain the theory. Due to their impact on the reionization process, here the strength of primordial fields is limited using the latest data on reionization and the observed UV-luminosity function of high-redshift galaxies. Given the steep faint-end slope of the luminosity function, faint galaxies contribute substantial ionizing photons, and the low-luminosity cutoff has an impact on the total budget thereof. Magnetic pressure from primordial fields affects such cutoff by preventing collapse in halos with mass below 10^{10} M_solar (B_0 / 3 nG)^3, with B_0 the co-moving field strength. In this letter, the implications of these effects are consistently incorporated in a simplified model for reionization, and the uncertainties due to the cosmological parameters, the reionization parameters and the observed UV luminosity function are addressed. We show...

  17. Non-thermal WIMPs and Primordial Black Holes

    CERN Document Server

    Georg, Julian; Watson, Scott

    2016-01-01

    Non-thermal histories for the early universe have received notable attention as they are a rich source of phenomenology, while also being well motivated by top-down approaches to beyond the Standard Model physics. The early (pre-BBN) matter phase in these models leads to enhanced growth of density perturbations on sub-Hubble scales. Here we consider whether primordial black hole formation associated with the enhanced growth is in conflict with existing observations. Such constraints depend on the tilt of the primordial power spectrum, and we find that non-thermal histories are tightly constrained in the case of a significantly blue spectrum. Alternatively, if dark matter is taken to be of non-thermal origin we can restrict the primordial power spectrum on scales inaccessible to CMB and LSS observations. We establish constraints for a wide range of scalar masses (reheat temperatures) with the most stringent bounds resulting from the formation of $10^{15}$ g black holes. These black holes would be evaporating t...

  18. Dynamical evolution of primordial dark matter haloes through mergers

    Science.gov (United States)

    Ogiya, Go; Nagai, Daisuke; Ishiyama, Tomoaki

    2016-09-01

    Primordial dark matter (DM) haloes are the smallest gravitationally bound DM structures from which the first stars, black holes and galaxies form and grow in the early universe. However, their structures are sensitive to the free streaming scale of DM, which in turn depends on the nature of DM particles. In this work, we test the hypothesis that the slope of the central cusps in primordial DM haloes near the free streaming scale depends on the nature of merging process. By combining and analysing data from a cosmological simulation with the cutoff in the small-scale matter power spectrum as well as a suite of controlled, high-resolution simulations of binary mergers, we find that (1) the primordial DM haloes form preferentially through major mergers in radial orbits; (2) their central DM density profile is more susceptible to a merging process compared to that of galaxy- and cluster-sized DM haloes; (3) consecutive major mergers drive the central density slope to approach the universal form characterized by the Navarro-Frenk-White profile, which is shown to be robust to the impacts of mergers and serves an attractor solution for the density structure of DM haloes. Our work highlights the importance of dynamical processes on the structure formation during the Dark Ages.

  19. Galaxy bispectrum, primordial non-Gaussianity and redshift space distortions

    CERN Document Server

    Tellarini, Matteo; Tasinato, Gianmassimo; Wands, David

    2016-01-01

    Measurements of the non-Gaussianity of the primordial density field have the power to considerably improve our understanding of the physics of inflation. Indeed, if we can increase the precision of current measurements by an order of magnitude, a null-detection would rule out many classes of scenarios for generating primordial fluctuations. Large-scale galaxy redshift surveys represent experiments that hold the promise to realise this goal. Thus, we model the galaxy bispectrum and forecast the accuracy with which it will probe the parameter $f_{\\rm NL}$, which represents the degree of primordial local-type non Gaussianity. Specifically, we address the problem of modelling redshift space distortions (RSD) in the tree-level galaxy bispectrum including $f_{\\rm NL}$. We find novel contributions associated with RSD, with the characteristic large scale amplification induced by local-type non-Gaussianity. These RSD effects must be properly accounted for in order to obtain un-biased measurements of $f_{\\rm NL}$ from ...

  20. Searching for Standard Clocks in the Primordial Universe

    CERN Document Server

    Chen, Xingang

    2012-01-01

    Classically oscillating massive fields can be used as "standard clocks" in the primordial universe. They generate features in primordial density perturbations that directly record the scale factor evolution a(t). Detecting and measuring these "fingerprint" signals is challenging but would provide a direct evidence for a specific primordial universe paradigm. In this paper, such a search is performed for the power spectrum of the Cosmic Microwave Background (CMB) anisotropies using the WMAP7 data. Although a good fit to the data privileges a scale around k=0.01 Mpc^(-1), we do not find statistical significance for, neither against, the presence of any feature. We then forecast the expected constraints a Planck-like CMB experiment can impose on the fingerprint parameters by using Markov-Chain-Monte-Carlo (MCMC) methods on mock data. We exhibit a high sensitivity zone for wavenumbers ranging from 0.01 Mpc^(-1) to 0.1 Mpc^(-1) in which fingerprints show up first on the posterior probability distribution of the wa...

  1. Galaxy bispectrum, primordial non-Gaussianity and redshift space distortions

    Science.gov (United States)

    Tellarini, Matteo; Ross, Ashley J.; Tasinato, Gianmassimo; Wands, David

    2016-06-01

    Measurements of the non-Gaussianity of the primordial density field have the power to considerably improve our understanding of the physics of inflation. Indeed, if we can increase the precision of current measurements by an order of magnitude, a null-detection would rule out many classes of scenarios for generating primordial fluctuations. Large-scale galaxy redshift surveys represent experiments that hold the promise to realise this goal. Thus, we model the galaxy bispectrum and forecast the accuracy with which it will probe the parameter fNL, which represents the degree of primordial local-type non Gaussianity. Specifically, we address the problem of modelling redshift space distortions (RSD) in the tree-level galaxy bispectrum including fNL. We find novel contributions associated with RSD, with the characteristic large scale amplification induced by local-type non-Gaussianity. These RSD effects must be properly accounted for in order to obtain un-biased measurements of fNL from the galaxy bispectrum. We propose an analytic template for the monopole which can be used to fit against data on large scales, extending models used in the recent measurements. Finally, we perform idealised forecasts on σfNL—the accuracy of the determination of local non-linear parameter fNL—from measurements of the galaxy bispectrum. Our findings suggest that current surveys can in principle provide fNL constraints competitive with Planck, and future surveys could improve them further.

  2. Conservation of Poultry Germplasm Through Cryopreservation of Primordial Germ Cells (PGCs

    Directory of Open Access Journals (Sweden)

    A R Setioko

    2008-06-01

    Full Text Available Indonesia has abundantly available genetic potential of local poultry that needs to be conserved for future use of poultry development. Live conservation of poultry, both in-situ and ex-situ, would be very expensive and has a risk of mortality due to diseases such as avian influenza. Cryopreservation of Primordial Germ Cells (PGCs, which are progenitor of eggs and spermatozoa, provides an alternative way to preserve both male and female genetic materials in poultry. PGCs in poultry can be specifically harvested from blatoderm or blood embryo, and preserved in a liquid nitrogen similar to sperm, ovum and embryo in large ruminant. Technique for producing germline chimeric chicken has been established by transferring PGCs into the circulated blood embryo where the original PGCs have been removed or inactivated. Mating of germline chimeras yields offsprings that are derived entirely from the donor stock. Conservation of genetic materials of Indonesian indigenous poultry through preservation of PGCs could be used for future poultry improvement.

  3. Planck 2015 results. XVII. Constraints on primordial non-Gaussianity

    Science.gov (United States)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Arroja, F.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Ballardini, M.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Basak, S.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Gauthier, C.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hamann, J.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Heavens, A.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huang, Z.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kim, J.; Kisner, T. S.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lacasa, F.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Lewis, A.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marinucci, D.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Münchmeyer, M.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Peiris, H. V.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Racine, B.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Shiraishi, M.; Smith, K.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutter, P.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Troja, A.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    The Planck full mission cosmic microwave background (CMB) temperature and E-mode polarization maps are analysed to obtain constraints on primordial non-Gaussianity (NG). Using three classes of optimal bispectrum estimators - separable template-fitting (KSW), binned, and modal - we obtain consistent values for the primordial local, equilateral, and orthogonal bispectrum amplitudes, quoting as our final result from temperature alone ƒlocalNL = 2.5 ± 5.7, ƒequilNL= -16 ± 70, , and ƒorthoNL = -34 ± 32 (68% CL, statistical). Combining temperature and polarization data we obtain ƒlocalNL = 0.8 ± 5.0, ƒequilNL= -4 ± 43, and ƒorthoNL = -26 ± 21 (68% CL, statistical). The results are based on comprehensive cross-validation of these estimators on Gaussian and non-Gaussian simulations, are stable across component separation techniques, pass an extensive suite of tests, and are consistent with estimators based on measuring the Minkowski functionals of the CMB. The effect of time-domain de-glitching systematics on the bispectrum is negligible. In spite of these test outcomes we conservatively label the results including polarization data as preliminary, owing to a known mismatch of the noise model in simulations and the data. Beyond estimates of individual shape amplitudes, we present model-independent, three-dimensional reconstructions of the Planck CMB bispectrum and derive constraints on early universe scenarios that generate primordial NG, including general single-field models of inflation, axion inflation, initial state modifications, models producing parity-violating tensor bispectra, and directionally dependent vector models. We present a wide survey of scale-dependent feature and resonance models, accounting for the "look elsewhere" effect in estimating the statistical significance of features. We also look for isocurvature NG, and find no signal, but we obtain constraints that improve significantly with the inclusion of polarization. The primordial

  4. The potential for archiving and reconstituting valuable strains of turkey (Meleagris gallopavo) using primordial germ cells.

    Science.gov (United States)

    Wade, Alexander J; French, Nick A; Ireland, Grenham W

    2014-04-01

    Diseases such as avian influenza can destroy turkey flocks, potentially resulting in the loss of valuable or rare genetic material. Consequently, there is an urgent need to develop a means to archive such germplasm. Germline chimeras produced by intravascular transfer of primordial germ cells (PGC) have been reported in other avian species but not turkeys. This study examined the feasibility of both establishing an archive of frozen PGC, and producing germline chimeras by injecting the thawed PGC into host embryos. To meet these aims, the following experiments were performed: (1) PGC identification within turkey embryos; (2) development of an efficient method for isolation of turkey PGC; (3) demonstration that PGC can be cryopreserved, recovered, and retain viability; (4) reinjection into embryos and detection of injected PGC. Primordial germ cells were identified using periodic acid-Schiff reagent and the immunological marker OLP-1. Bloodstream PGC were isolated using Ficoll density gradient centrifugation with PGC recovery peaking at stages 13, 14, and 15 with 32 ± 4.9, 33 ± 6.4, and 26 ± 5.4 PGC recovered, respectively. Primordial germ cells were frozen using Dulbecco's modified Eagle medium, 20% fetal calf serum, and 10% dimethylsulfoxide and demonstrated 90 ± 1.7% viability after 3 mo frozen in liquid nitrogen. Freshly isolated and frozen thawed DiI- and Q-Tracker-labeled PGC repopulated stage 30 gonads after vascular transfer into ex ovo cultured embryos. The DiI-labeled cells repopulated gonads less frequently, with 36 ± 13.2% of gonads containing the DiI-labeled PGC, and 7 ± 3.8% of reinjected PGC reaching the gonads of positive embryos. The Q-tracker-labeled cells were detected more frequently in embryos, with 67 ± 21.1% having positive signals, and 44 ± 4.9% of reinjected Q-tracker-labeled PGC colonized the gonads of positive embryos. This study demonstrated the feasibility of using turkey PGC to archive turkey germplasm from different strains

  5. Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation.

    Directory of Open Access Journals (Sweden)

    Hongkai Ji

    Full Text Available The functions of key oncogenic transcription factors independent of context have not been fully delineated despite our richer understanding of the genetic alterations in human cancers. The MYC oncogene, which produces the Myc transcription factor, is frequently altered in human cancer and is a major regulatory hub for many cancers. In this regard, we sought to unravel the primordial signature of Myc function by using high-throughput genomic approaches to identify the cell-type independent core Myc target gene signature. Using a model of human B lymphoma cells bearing inducible MYC, we identified a stringent set of direct Myc target genes via chromatin immunoprecipitation (ChIP, global nuclear run-on assay, and changes in mRNA levels. We also identified direct Myc targets in human embryonic stem cells (ESCs. We further document that a Myc core signature (MCS set of target genes is shared in mouse and human ESCs as well as in four other human cancer cell types. Remarkably, the expression of the MCS correlates with MYC expression in a cell-type independent manner across 8,129 microarray samples, which include 312 cell and tissue types. Furthermore, the expression of the MCS is elevated in vivo in Eμ-Myc transgenic murine lymphoma cells as compared with premalignant or normal B lymphocytes. Expression of the MCS in human B cell lymphomas, acute leukemia, lung cancers or Ewing sarcomas has the highest correlation with MYC expression. Annotation of this gene signature reveals Myc's primordial function in RNA processing, ribosome biogenesis and biomass accumulation as its key roles in cancer and stem cells.

  6. The primordial follicle reserve is not renewed after chemical or γ-irradiation mediated depletion.

    Science.gov (United States)

    Kerr, J B; Brogan, L; Myers, M; Hutt, K J; Mladenovska, T; Ricardo, S; Hamza, K; Scott, C L; Strasser, A; Findlay, J K

    2012-04-01

    Reports indicate that germ-line stem cells present in adult mice can rapidly generate new oocytes and contribute to the primordial follicle reserve following conditions of ovotoxic stress. We further investigated the hypothesis that adult mice have the capacity to generate new oocytes by monitoring primordial follicle numbers throughout postnatal life and following depletion of the primordial follicle reserve by exposure to doxorubicin (DXR), trichostatin A (TSA), or whole-body γ-irradiation. We show that primordial follicle number remains stable in adult C57BL/6 mice between the ages of 25 and 100 days. However, within 2 days of treatment with DXR or TSA, primordial follicle numbers had declined to 65 and 51% respectively (Pprimordial follicles 5 days after treatment, with no indication of follicular renewal. We conclude that neo-folliculogenesis does not occur following chemical or γ-irradiation mediated depletion of the primordial follicle reserve.

  7. Primordial blackholes and gravitational waves for an inflection-point model of inflation

    OpenAIRE

    Choudhury, Sayantan; Mazumdar, Anupam

    2014-01-01

    In this article we provide a new closed relationship between cosmic abundance of primordial gravitational waves and primordial blackholes that originated from initial inflationary perturbations for inflection-point models of inflation where inflation occurs below the Planck scale. The current Planck constraint on tensor-to-scalar ratio, running of the spectral tilt, and from the abundance of dark matter content in the universe, we can deduce a strict bound on the current abundance of primordi...

  8. Improved constraints on primordial blackholes and gravitational waves for a generic model of inflation

    CERN Document Server

    Choudhury, Sayantan

    2014-01-01

    In this article we provide a new closed relationship between the cosmic abundance of primordial gravitational waves and primordial blackholes originated from initial inflationary perturbations for a generic model of inflation where inflation occurs below the Planck scale. We have obtained a strict bound on the current abundance of primordial blackholes from the Planck measurements, $9.99712\\times 10^{-3}<\\Omega_{PBH}h^{2}< 9.99736\\times 10^{-3}$.

  9. Induction of ovarian primordial follicle assembly by connective tissue growth factor CTGF.

    Science.gov (United States)

    Schindler, Ryan; Nilsson, Eric; Skinner, Michael K

    2010-09-24

    Primordial follicle assembly is a process that occurs when oocyte nests break down to form individual primordial follicles. The size of this initial pool of primordial follicles in part determines the reproductive lifespan of the female. Connective tissue growth factor (CTGF) was identified as a potential regulatory candidate for this process in a previous microarray analysis of follicle development. The current study examines the effects of CTGF and associated transforming growth factor beta 1 (TGFβ-1) on follicle assembly. Ovaries were removed from newborn rat pups and placed in an organ culture system. The ovaries treated with CTGF for two days were found to have an increased proportion of assembled follicles. CTGF was found to regulate the ovarian transcriptome during primordial follicle assembly and an integrative network of genes was identified. TGFβ-1 had no effect on primordial follicle assembly and in combination with CTGF decreased oocyte number in the ovary after two days of culture. Over ten days of treatment only the combined treatment of CTGF and TGFβ-1 was found to cause an increase in the proportion of assembled follicles. Interestingly, treatment with TGFβ-1 alone resulted in fewer total oocytes in the ovary and decreased the primordial follicle pool size after ten days of culture. Observations indicate that CTGF alone or in combination with TGFβ-1 stimulates primordial follicle assembly and TGFβ-1 can decrease the primordial follicle pool size. These observations suggest the possibility of manipulating primordial follicle pool size and influencing female reproductive lifespan.

  10. Low expression of SEMA6C accelerates the primordial follicle activation in the neonatal mouse ovary.

    Science.gov (United States)

    Zhou, Su; Yan, Wei; Shen, Wei; Cheng, Jing; Xi, Yueyue; Yuan, Suzhen; Fu, Fangfang; Ding, Ting; Luo, Aiyue; Wang, Shixuan

    2017-09-07

    The primordial follicle assembly, activation and the subsequent development are critical processes for female reproduction. A limited number of primordial follicles are activated to enter the growing follicle pool each wave, and the primordial follicle pool progressively diminishes over a woman's life-time. The number of remaining primordial follicles represents the ovarian reserve. Identification and functional investigation of the factors involved in follicular initial recruitment will be of great significance to the understanding of the female reproduction process and ovarian ageing. In this study, we aimed to study whether and how semaphorin 6C (Sema6c) regulated the primordial follicle activation in the neonatal mouse ovary. The attenuation of SEMA6C expression by SiRNA accelerated the primordial follicle activation in the in vitro ovary culture system. PI3K-AKT-rpS6 pathway was activated when SEMA6C expression was down-regulated. And the LY294002 could reverse the effect of low SEMA6C expression on primordial follicle activation. Our findings revealed that Sema6c was involved in the activation of primordial follicles, and the down-regulation of SEMA6C led to massive primordial follicle activation by interacting with the PI3K-AKT-rpS6 pathway, which might also provide valuable information for understanding premature ovarian failure and ovarian ageing. © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  11. Coacervate droplets, proteinoid microspheres, and the genetic apparatus

    Science.gov (United States)

    Fox, S. W.

    1974-01-01

    Differences between typical coacervate droplets and typical proteinoid microspheres are examined. It is pointed out that coacervate droplets are produced from polymers obtained from contemporary organisms. The microspheres considered are aggregates of proteinoid formed from monomeric amino acids under geologically relevant conditions. Aspects regarding the primordial sequence are discussed along with the origin of the genetic apparatus and the genetic code.

  12. Neuronal migration disorders in microcephalic osteodysplastic primordial dwarfism type I/III.

    Science.gov (United States)

    Juric-Sekhar, Gordana; Kapur, Raj P; Glass, Ian A; Murray, Mitzi L; Parnell, Shawn E; Hevner, Robert F

    2011-04-01

    Microcephalic osteodysplastic primordial dwarfism (MOPD) is a rare microlissencephaly syndrome, with at least two distinct phenotypic and genetic types. MOPD type II is caused by pericentrin mutations, while types I and III appear to represent a distinct entity (MOPD I/III) with variably penetrant phenotypes and unknown genetic basis. The neuropathology of MOPD I/III is little understood, especially in comparison to other forms of lissencephaly. Here, we report postmortem brain findings in an 11-month-old female infant with MOPD I/III. The cerebral cortex was diffusely pachygyric, with a right parietal porencephalic lesion. Histologically, the cortex was abnormally thick and disorganized. Distinct malformations were observed in different cerebral lobes, as characterized using layer-specific neuronal markers. Frontal cortex was severely disorganized and coated with extensive leptomeningeal glioneuronal heterotopia. Temporal cortex had a relatively normal 6-layered pattern, despite cortical thickening. Occipital cortex was variably affected. The corpus callosum was extremely hypoplastic. Brainstem and cerebellar malformations were also present, as well as old necrotic foci. Findings in this case suggest that the cortical malformation in MOPD I/III is distinct from other forms of pachygyria-lissencephaly.

  13. Constraining primordial vector mode from B-mode polarization

    Energy Technology Data Exchange (ETDEWEB)

    Saga, Shohei; Ichiki, Kiyotomo [Department of Physics and Astrophysics, Nagoya University, Aichi 464-8602 (Japan); Shiraishi, Maresuke, E-mail: saga.shohei@nagoya-u.jp, E-mail: maresuke.shiraishi@pd.infn.it, E-mail: ichiki@a.phys.nagoya-u.ac.jp [Dipartimento di Fisica e Astronomia ' ' G. Galilei' ' , Università degli Studi di Padova, via Marzolo 8, I-35131, Padova (Italy)

    2014-10-01

    The B-mode polarization spectrum of the Cosmic Microwave Background (CMB) may be the smoking gun of not only the primordial tensor mode but also of the primordial vector mode. If there exist nonzero vector-mode metric perturbations in the early Universe, they are known to be supported by anisotropic stress fluctuations of free-streaming particles such as neutrinos, and to create characteristic signatures on both the CMB temperature, E-mode, and B-mode polarization anisotropies. We place constraints on the properties of the primordial vector mode characterized by the vector-to-scalar ratio r{sub v} and the spectral index n{sub v} of the vector-shear power spectrum, from the Planck and BICEP2 B-mode data. We find that, for scale-invariant initial spectra, the ΛCDM model including the vector mode fits the data better than the model including the tensor mode. The difference in χ{sup 2} between the vector and tensor models is Δχ{sup 2} = 3.294, because, on large scales the vector mode generates smaller temperature fluctuations than the tensor mode, which is preferred for the data. In contrast, the tensor mode can fit the data set equally well if we allow a significantly blue-tilted spectrum. We find that the best-fitting tensor mode has a large blue tilt and leads to an indistinct reionization bump on larger angular scales. The slightly red-tilted vector mode supported by the current data set can also create O(10{sup -22})-Gauss magnetic fields at cosmological recombination. Our constraints should motivate research that considers models of the early Universe that involve the vector mode.

  14. Hadean Earth and primordial continents: The cradle of prebiotic life

    Directory of Open Access Journals (Sweden)

    M. Santosh

    2017-03-01

    Full Text Available The Hadean history of Earth is shrouded in mystery and it is considered that the planet was born dry with no water or atmosphere. The Earth-Moon system had many features in common during the birth stage. Solidification of the dry magma ocean at 4.53 Ga generated primordial continents with komatiite. We speculate that the upper crust was composed of fractionated gabbros and the middle felsic crust by anorthosite at ca. 21 km depth boundary, underlain by meta-anorthosite (grossular + kyanite + quartz down to 50–60 km in depth. The thickness of the mafic KREEP basalt in the lower crust, separating it from the underlying upper mantle is not well-constrained and might have been up to ca. 100–200 km depending on the degree of fractionation and gravitational stability versus surrounding mantle density. The primordial continents must have been composed of the final residue of dry magma ocean and enriched in several critical elements including Ca, Mg, Fe, Mn, P, K, and Cl which were exposed on the surface of the dry Earth. Around 190 million years after the solidification of the magma ocean, “ABEL bombardment” delivered volatiles including H2O, CO2, N2 as well as silicate components through the addition of icy asteroids. This event continued for 200 Myr with subordinate bombardments until 3.9 Ga, preparing the Earth for the prebiotic chemical evolution and as the cradle of first life. Due to vigorous convection arising from high mantle potential temperatures, the primordial continents disintegrated and were dragged down to the deep mantle, marking the onset of Hadean plate tectonics.

  15. The future of primordial features with 21 cm tomography

    Science.gov (United States)

    Chen, Xingang; Meerburg, P. Daniel; Münchmeyer, Moritz

    2016-09-01

    Detecting a deviation from a featureless primordial power spectrum of fluctuations would give profound insight into the physics of the primordial Universe. Depending on their nature, primordial features can either provide direct evidence for the inflation scenario or pin down details of the inflation model. Thus far, using the cosmic microwave background (CMB) we have only been able to put stringent constraints on the amplitude of features, but no significant evidence has been found for such signals. Here we explore the limit of the experimental reach in constraining such features using 21 cm tomography at high redshift. A measurement of the 21 cm power spectrum from the Dark Ages is generally considered as the ideal experiment for early Universe physics, with potentially access to a large number of modes. We consider three different categories of theoretically motivated models: the sharp feature models, resonance models, and standard clock models. We study the improvements on bounds on features as a function of the total number of observed modes and identify parameter degeneracies. The detectability depends critically on the amplitude, frequency and scale-location of the features, as well as the angular and redshift resolution of the experiment. We quantify these effects by considering different fiducial models. Our forecast shows that a cosmic variance limited 21 cm experiment measuring fluctuations in the redshift range 30 <= z <= 100 with a 0.01-MHz bandwidth and sub-arcminute angular resolution could potentially improve bounds by several orders of magnitude for most features compared to current Planck bounds. At the same time, 21 cm tomography also opens up a unique window into features that are located on very small scales.

  16. Observing the Unobservable: Catching a Glimpse of the Primordial Universe

    Science.gov (United States)

    Fialkov, Anastasia

    In this thesis we discuss the primordial Universe and prospects for detection of smoking gun signatures related to the earliest stages of cosmic evolution. In the first part of this thesis we focus on the epoch of formation of the very first stars and galaxies when the Universe was only ∼ 30-200 million years old. We explore the details of primordial structure formation taking into account a complete set of initial conditions, which include fluctuations in density as well as relative velocities between dark matter and baryons at recombination. We discuss observational prospects related to this era using the redshifted 21-cm emission line of neutral hydrogen and explore the dependence of this radio signal on the complex astrophysics of the early epoch as well as on the relative velocities. This research shows that the prospects for detection of the redshifted 21-cm signal related to the early period are much more promising than was previously thought. The results presented here are likely to stimulate observational efforts focused on the epoch of the primordial star formation. In the second part, we consider cosmological signatures related to a modified set of initial conditions from inflation, focusing on a particular scenario of pre-inflationary relics which was originally motivated by string theory. We entertain the possibility that one such a relic may affect initial conditions for structure formation within our observable Universe, and explore its observational consequences. This study explores the interface between high energy theories and cosmic measurements and opens a unique observational window at the high energy scales of ∼ 10^16 - 10^18 GeV.

  17. Erratum: The Primordial Abundance of 4He: An Update

    Science.gov (United States)

    Olive, Keith A.; Skillman, Evan; Steigman, Gary

    1997-11-01

    In the paper ``The Primordial Abundance of 4He: An Update'' by Keith A. Olive, Evan Skillman, and Gary Steigman (ApJ, 483, 788 [1997]), Evan Skillman's and Gary Steigman's names were interchanged, giving each the wrong address. The correct order of the authors is Keith A. Olive, Evan Skillman, and Gary Steigman; Evan Skillman's address is School of Physics and Astronomy, University of Minnesota, Minneapolis, MN 55455, and Gary Steigman's address is Department of Physics and Astronomy, The Ohio State University, Columbus, OH 43210.

  18. The Burst Mode of Accretion in Primordial Star Formation

    CERN Document Server

    DeSouza, A L; Basu, S

    2012-01-01

    We present simulation results for the formation and long-term evolution of a primordial protostellar disk harbored by a first star. Using a 2+1D nonaxisymmetric thin disk numerical simulation, together with a barotropic relation for the gas, we are able to probe ~20 kyr of the disk's evolution. During this time period we observe fragmentation leading to loosely bound gaseous clumps within the disk. These are then torqued inward and accreted onto the growing protostar, giving rise to a burst phenomenon. The luminous feedback produced by this mechanism may have important consequences for the subsequent growth of the protostar.

  19. Inflationary primordial black holes as all dark matter

    Science.gov (United States)

    Inomata, Keisuke; Kawasaki, Masahiro; Mukaida, Kyohei; Tada, Yuichiro; Yanagida, Tsutomu T.

    2017-08-01

    Following a new microlensing constraint on primordial black holes (PBHs) with ˜1 020- 1 028 g [H. Niikura et al., arXiv:1701.02151.], we revisit the idea of PBH as all dark matter (DM). We have shown that the updated observational constraints suggest the viable mass function for PBHs as all DM to have a peak at ≃1 020 g with a small width σ ≲0.1 , by imposing observational constraints on an extended mass function in a proper way. We have also provided an inflation model that successfully generates PBHs as all DM fulfilling this requirement.

  20. On the Free Energy That Drove Primordial Anabolism

    Directory of Open Access Journals (Sweden)

    Michael Kaufmann

    2009-04-01

    Full Text Available A key problem in understanding the origin of life is to explain the mechanism(s that led to the spontaneous assembly of molecular building blocks that ultimately resulted in the appearance of macromolecular structures as they are known in modern biochemistry today. An indispensable thermodynamic prerequisite for such a primordial anabolism is the mechanistic coupling to processes that supplied the free energy required. Here I review different sources of free energy and discuss the potential of each form having been involved in the very first anabolic reactions that were fundamental to increase molecular complexity and thus were essential for life.

  1. The quark-hadron phase transition and primordial nucleosynthesis

    Science.gov (United States)

    Hogan, Craig J.

    1987-01-01

    After presenting the current view of the processes taking place during the cosmological transition from 'quark soup' to normal hadron matter, attention is given to what happens to cosmological nucleosynthesis in the presence of small-scale baryon inhomogeneities. The QCD phase transition is among the plausible sources of this inhomogeneity. It is concluded that the formation of primordial 'quark nuggets' and other cold exotica requires very low entropy regions at the outset, and that even the more modest nonlinearities perturbing nucleosynthesis probably require some ingredient in addition to a quiescent, mildly supercooled transition.

  2. The quark-hadron phase transition and primordial nucleosynthesis

    Science.gov (United States)

    Hogan, Craig J.

    1987-01-01

    After presenting the current view of the processes taking place during the cosmological transition from 'quark soup' to normal hadron matter, attention is given to what happens to cosmological nucleosynthesis in the presence of small-scale baryon inhomogeneities. The QCD phase transition is among the plausible sources of this inhomogeneity. It is concluded that the formation of primordial 'quark nuggets' and other cold exotica requires very low entropy regions at the outset, and that even the more modest nonlinearities perturbing nucleosynthesis probably require some ingredient in addition to a quiescent, mildly supercooled transition.

  3. Primordial follicle activation in the ovary of Ames dwarf mice

    OpenAIRE

    Schneider, Augusto; Zhi, Xu; Moreira, Fabiana; Lucia, Thomaz; Mondadori,Rafael Gianella; Masternak, Michal M.

    2014-01-01

    Background The insulin receptor substrate 1 (IRS1), phosphoinositide 3-kinase (Pi3k), protein kinase B (Akt1), Forkhead Box O3a (FOXO3a) pathway is directly involved in aging and ovarian activation of follicle growth. Therefore, the aim of this work was to measure the expression of genes related to the ovarian pathway for activation of primordial follicles and FOXO3a protein phosphorylation between young and old female Ames dwarf (df/df) and normal (N) mice. Methods For this study ovaries fro...

  4. Primordial power spectrum of tensor perturbations in Finsler spacetime

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xin [Chongqing University, Department of Physics, Chongqing (China); Chinese Academy of Sciences, State Key Laboratory Theoretical Physics, Institute of Theoretical Physics, Beijing (China); Wang, Sai [Chinese Academy of Sciences, State Key Laboratory Theoretical Physics, Institute of Theoretical Physics, Beijing (China)

    2016-02-15

    We first investigate the gravitational wave in the flat Finsler spacetime. In the Finslerian universe, we derive the perturbed gravitational field equation with tensor perturbations. The Finslerian background spacetime breaks rotational symmetry and induces parity violation. Then we obtain the modified primordial power spectrum of the tensor perturbations. The parity violation feature requires that the anisotropic effect contributes to the TT, TE, EE, BB angular correlation coefficients with l{sup '} = l + 1 and TB, EB with l{sup '} = l. The numerical results show that the anisotropic contributions to the angular correlation coefficients depend on m, and TE and ET angular correlation coefficients are different. (orig.)

  5. Scale-dependent CMB asymmetry from primordial configuration

    Energy Technology Data Exchange (ETDEWEB)

    Kohri, Kazunori [Cosmophysics group, Theory Center, IPNS, KEK, and The Graduate University for Advanced Study (Sokendai), Tsukuba 305-0801 (Japan); Lin, Chia-Min [Department of Physics, Chuo University, Bunkyo-ku, Tokyo 112 (Japan); Matsuda, Tomohiro, E-mail: kohri@post.kek.jp, E-mail: lin@chuo-u.ac.jp, E-mail: matsuda@sit.ac.jp [Laboratory of Physics, Saitama Institute of Technology, Fukaya, Saitama 369-0293 (Japan)

    2014-08-01

    We demonstrate that a topological defect can explain the hemispherical power asymmetry of the CMB. The first point is that a defect configuration, which already exists prior to inflation, can source asymmetry of the CMB. The second point is that modulation mechanisms, such as the curvaton and other modulation mechanisms, can explain scale-dependence of the asymmetry. Using a simple analysis of the δ N formalism, we show models in which scale-dependent hemispherical power asymmetry is explained by primordial configuration of a defect.

  6. Les Houches 1999 Summer School, Session 71 : The Primordial Universe

    CERN Document Server

    Schäffer, R; Silk, J; David, F

    2000-01-01

    This book reviews the interconnection of cosmology and particle physics over the last decade. It provides introductory courses in supersymmetry, superstring and M-theory, responding to an increasing interest to evaluate the cosmological consequences of these theories. Based on a series of extended courses providing an introduction to the physics of the very early universe, in the light of the most recent advances in our understanding of the fundamental interactions, it reviews all the classical issues (inflation, primordial fluctuations, dark matter, baryogenesis), but also introduces the most

  7. Primordial gravitational waves measurements and anisotropies of CMB polarization rotation

    Directory of Open Access Journals (Sweden)

    Si-Yu Li

    2015-12-01

    Full Text Available Searching for the signal of primordial gravitational waves in the B-modes (BB power spectrum is one of the key scientific aims of the cosmic microwave background (CMB polarization experiments. However, this could be easily contaminated by several foreground issues, such as the interstellar dust grains and the galactic cyclotron electrons. In this paper we study another mechanism, the cosmic birefringence, which can be introduced by a CPT-violating interaction between CMB photons and an external scalar field. Such kind of interaction could give rise to the rotation of the linear polarization state of CMB photons, and consequently induce the CMB BB power spectrum, which could mimic the signal of primordial gravitational waves at large scales. With the recently released polarization data of BICEP2 and the joint analysis data of BICEP2/Keck Array and Planck, we perform a global fitting analysis on constraining the tensor-to-scalar ratio r by considering the polarization rotation angle [α(nˆ] which can be separated into a background isotropic part [α¯] and a small anisotropic part [Δα(nˆ]. Since the data of BICEP2 and Keck Array experiments have already been corrected by using the “self-calibration” method, here we mainly focus on the effects from the anisotropies of CMB polarization rotation angle. We find that including Δα(nˆ in the analysis could slightly weaken the constraints on the tensor-to-scalar ratio r, when using current CMB polarization measurements. We also simulate the mock CMB data with the BICEP3-like sensitivity. Very interestingly, we find that if the effects of the anisotropic polarization rotation angle could not be taken into account properly in the analysis, the constraints on r will be dramatically biased. This implies that we need to break the degeneracy between the anisotropies of the CMB polarization rotation angle and the CMB primordial tensor perturbations, in order to measure the signal of primordial

  8. The quark-hadron phase transition and primordial nucleosynthesis

    Science.gov (United States)

    Hogan, Craig J.

    After presenting the current view of the processes taking place during the cosmological transition from 'quark soup' to normal hadron matter, attention is given to what happens to cosmological nucleosynthesis in the presence of small-scale baryon inhomogeneities. The QCD phase transition is among the plausible sources of this inhomogeneity. It is concluded that the formation of primordial 'quark nuggets' and other cold exotica requires very low entropy regions at the outset, and that even the more modest nonlinearities perturbing nucleosynthesis probably require some ingredient in addition to a quiescent, mildly supercooled transition.

  9. Primordial power spectrum of tensor perturbations in Finsler spacetime

    CERN Document Server

    Li, Xin

    2015-01-01

    We first investigate the gravitational wave in the flat Finsler spacetime. In the Finslerian universe, we derive the perturbed gravitational field equation with tensor perturbations. The Finslerian background spacetime breaks rotational symmetry and induces parity violation. Then we obtain the modified primordial power spectrum of tensor perturbations. The parity violation feature requires that the anisotropic effect contributes to $TT,TE,EE,BB$ angular correlation coefficients with $l'=l+1$ and $TB,EB$ with $l'=l$. The numerical results show that the anisotropic contributions to angular correlation coefficients depend on $m$, and $TE$ and $ET$ angular correlation coefficients are different.

  10. Primordial planets, comets and moons foster life in the cosmos

    CERN Document Server

    Gibson, Carl H; Schild, Rudolph E

    2010-01-01

    A key result of hydrogravitational dynamics cosmology relevant to astrobiology is the early formation of vast numbers of hot primordial-gas planets in million-solar-mass clumps as the dark matter of galaxies and the hosts of first life. Photon viscous forces in the expanding universe of the turbulent big bang prevent fragmentations of the plasma for mass scales smaller than protogalaxies. At the plasma to gas transition 300,000 years after the big bang, the 10^7 decrease in kinematic viscosity {\

  11. Lattice Calculation of the Decay of Primordial Higgs Condensate

    CERN Document Server

    Enqvist, Kari; Rusak, Stanislav; Weir, David

    2015-01-01

    We study the resonant decay of the primordial Standard Model Higgs condensate after inflation into $SU(2)$ gauge bosons on the lattice. We find that the non-Abelian interactions between the gauge bosons quickly extend the momentum distribution towards high values, efficiently destroying the condensate after the onset of backreaction. For the inflationary scale $H = 10^8$ GeV, we find that 90% of the Higgs condensate has decayed after $n \\sim 10$ oscillation cycles. This differs significantly from the Abelian case where, given the same couplings strengths, most of the condensate would persist after the resonance.

  12. Lattice calculation of the decay of primordial Higgs condensate

    Science.gov (United States)

    Enqvist, Kari; Nurmi, Sami; Rusak, Stanislav; Weir, David J.

    2016-02-01

    We study the resonant decay of the primordial Standard Model Higgs condensate after inflation into SU(2) gauge bosons on the lattice. We find that the non-Abelian interactions between the gauge bosons quickly extend the momentum distribution towards high values, efficiently destroying the condensate after the onset of backreaction. For the inflationary scale H = 108 GeV, we find that 90% of the Higgs condensate has decayed after n~ 10 oscillation cycles. This differs significantly from the Abelian case where, given the same coupling strengths, most of the condensate would persist after the resonance.

  13. Polytropic equation of state and primordial quantum fluctuations

    Energy Technology Data Exchange (ETDEWEB)

    Freitas, R.C.; Goncalves, S.V.B. [Universidade Federal do Espirito Santo, Departamento de Fisica, Vitoria, Espirito Santo (Brazil)

    2014-12-01

    We study the primordial Universe in a cosmological model where inflation is driven by a fluid with a polytropic equation of state p = αρ + ρ{sup 1+1/n}. We calculate the dynamics of the scalar factor and build a Universe with constant density at the origin. We also find the equivalent scalar field that could create such an equation of state and calculate the corresponding slow-roll parameters. We calculate the scalar perturbations, the scalar power spectrum, and the spectral index. (orig.)

  14. Probing the primordial Universe with MeerKAT and DES

    CERN Document Server

    Fonseca, José; Santos, Mário G

    2016-01-01

    It is usually assumed that we will need to wait until next-generation surveys like Euclid, LSST and SKA, in order to improve on the current best constraints on primordial non-Gaussianity from the Planck experiment. We show that two contemporary surveys, with the SKA precursor MeerKAT and the Dark Energy Survey (DES), can be combined using the multi-tracer technique to deliver an accuracy on measurement of $f_{\\rm NL}$ that is up to four times better than Planck.

  15. Cryopreservation of specialized chicken lines using cultured primordial germ cells.

    Science.gov (United States)

    Nandi, S; Whyte, J; Taylor, L; Sherman, A; Nair, V; Kaiser, P; McGrew, M J

    2016-08-01

    Biosecurity and sustainability in poultry production requires reliable germplasm conservation. Germplasm conservation in poultry is more challenging in comparison to other livestock species. Embryo cryopreservation is not feasible for egg-laying animals, and chicken semen conservation has variable success for different chicken breeds. A potential solution is the cryopreservation of the committed diploid stem cell precursors to the gametes, the primordial germ cells ( PGCS: ). Primordial germ cells are the lineage-restricted cells found at early embryonic stages in birds and form the sperm and eggs. We demonstrate here, using flocks of partially inbred, lower-fertility, major histocompatibility complex- ( MHC-: ) restricted lines of chicken, that we can easily derive and cryopreserve a sufficient number of independent lines of male and female PGCs that would be sufficient to reconstitute a poultry breed. We demonstrate that germ-line transmission can be attained from these PGCs using a commercial layer line of chickens as a surrogate host. This research is a major step in developing and demonstrating that cryopreserved PGCs could be used for the biobanking of specialized flocks of birds used in research settings. The prospective application of this technology to poultry production will further increase sustainability to meet current and future production needs. © The Author 2016. Published by Oxford University Press on behalf of Poultry Science Association.

  16. Dark Matter Density Spikes around Primordial Black Holes

    CERN Document Server

    Eroshenko, Yu N

    2016-01-01

    We show that density spikes begin to form from dark matter particles around primordial black holes immediately after their formation at the radiation-dominated cosmological stage. This follows from the fact that in the thermal velocity distribution of particles there are particles with low velocities that remain in finite orbits around black holes and are not involved in the cosmological expansion. The accumulation of such particles near black holes gives rise to density spikes. These spikes are considerably denser than those that are formed later by the mechanism of secondary accretion. The density spikes must be bright gamma-ray sources. Comparison of the calculated signal from particle annihilation with the Fermi-LAT data constrains the present-day cosmological density parameter for primordial black holes with masses $M_{\\rm BH}\\geq10^{-8}M_\\odot$ from above by values from $\\Omega_{\\rm BH}\\leq1$ to $\\Omega_{\\rm BH}\\leq10^{-8}$, depending on $M_{\\rm BH}$. These constraints are several orders of magnitude mo...

  17. Constraining the primordial power spectrum from SNIa lensing dispersion

    Energy Technology Data Exchange (ETDEWEB)

    Ben-Dayan, Ido [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Kalaydzhyan, Tigran [State Univ. of New York, Stony Brook, NY (United States). Dept. of Physics and Astronomy

    2013-09-15

    The (absence of detecting) lensing dispersion of Supernovae type Ia (SNIa) can be used as a novel and extremely efficient probe of cosmology. In this preliminary example we analyze its consequences for the primordial power spectrum. The main setback is the knowledge of the power spectrum in the non-linear regime, 1 Mpc{sup -1}primordial power spectrum. The probe extends our handle on the spectrum to a total of 12-15 inflation e-folds. These constraints are so strong that they are already ruling out a large portion of the parameter space allowed by PLANCK for running {alpha}{identical_to}dn{sub s}/d ln k and running of running {beta}{identical_to}d{sup 2}n{sub s}/d ln k{sup 2}. The bounds follow a linear relation to a very good accuracy. A conservative bound disfavours any enhancement above the line {beta}(k{sub 0})=0.032-0.41{alpha}(k{sub 0}) and a realistic estimate disfavours any enhancement above the line {beta}(k{sub 0})=0.019-0.45{alpha}(k{sub 0}).

  18. A weak lensing view on primordial non-Gaussianities

    CERN Document Server

    Schaefer, Bjoern Malte; Gerstenlauer, Mischa; Byrnes, Christian T

    2011-01-01

    We investigate the signature of primordial non-Gaussianities in the weak lensing bispectrum, in particular the signals generated by local, orthogonal and equilateral non-Gaussianities. The questions we address include the signal-to-noise ratio generated in the Euclid weak lensing survey (we find the 1sigma-errors for fNL are 200, 575 and 1628 for local, orthogonal and equilateral non-Gaussianities, respectively), misestimations of fNL if one chooses the wrong non-Gaussianity model (misestimations by up to a factor of +/-3 in fNL are possible, depending on the choice of the model), the probability of noticing such a mistake (improbably large values for the chi^2-functional occur from fNL 200 on), degeneracies of the primordial bispectrum with other cosmological parameters (only the matter density Omega_m plays a significant role), and the subtraction of the much larger, structure-formation generated bispectrum. If a prior on a standard wCDM-parameter set is available from Euclid and Planck, the structure forma...

  19. POLARBEAR Constraints on Cosmic Birefringence and Primordial Magnetic Fields

    CERN Document Server

    Ade, Peter A R; Atlas, Matt; Baccigalupi, Carlo; Barron, Darcy; Boettger, David; Borrill, Julian; Chapman, Scott; Chinone, Yuji; Cukierman, Ari; Dobbs, Matt; Ducout, Anne; Dunner, Rolando; Elleflot, Tucker; Errard, Josquin; Fabbian, Giulio; Feeney, Stephen; Feng, Chang; Gilbert, Adam; Goeckner-Wald, Neil; Groh, John; Hall, Grantland; Halverson, Nils W; Hasegawa, Masaya; Hattori, Kaori; Hazumi, Masashi; Hill, Charles; Holzapfel, William L; Hori, Yasuto; Howe, Logan; Inoue, Yuki; Jaehnig, Gregory C; Jaffe, Andrew H; Jeong, Oliver; Katayama, Nobuhiko; Kaufman, Jonathan P; Keating, Brian; Kermish, Zigmund; Keskitalo, Reijo; Kisner, Theodore; Kusaka, Akito; Jeune, Maude Le; Lee, Adrian T; Leitch, Erik M; Leon, David; Li, Yun; Linder, Eric; Lowry, Lindsay; Matsuda, Frederick; Matsumura, Tomotake; Miller, Nathan; Montgomery, Josh; Myers, Michael J; Navaroli, Martin; Nishino, Haruki; Okamura, Takahiro; Paar, Hans; Peloton, Julien; Pogosian, Levon; Poletti, Davide; Puglisi, Giuseppe; Raum, Christopher; Rebeiz, Gabriel; Reichardt, Christian L; Richards, Paul L; Ross, Colin; Rotermund, Kaja M; Schenck, David E; Sherwin, Blake D; Shimon, Meir; Shirley, Ian; Siritanasak, Praween; Smecher, Graeme; Stebor, Nathan; Steinbach, Bryan; Suzuki, Aritoki; Suzuki, Jun-ichi; Tajima, Osamu; Takakura, Satoru; Tikhomirov, Alexei; Tomaru, Takayuki; Whitehorn, Nathan; Wilson, Brandon; Yadav, Amit; Zahn, Alex; Zahn, Oliver

    2015-01-01

    We constrain anisotropic cosmic birefringence using four-point correlations of even-parity $E$-mode and odd-parity $B$-mode polarization in the cosmic microwave background measurements made by the POLARBEAR experiment in its first season of observations. We find that the anisotropic cosmic birefringence signal from any parity violating processes is consistent with zero. The Faraday rotation from anisotropic cosmic birefringence can be compared with the equivalent quantity generated by primordial magnetic fields if they existed. The POLARBEAR non-detection translates into a 95% confidence level (C.L.) upper limit of 93 nano-Gauss (nG) on the amplitude of an equivalent primordial magnetic field inclusive of systematic uncertainties. This four-point correlation constraint on Faraday rotation is about 15 times tighter than the upper limit of 1380 nG inferred from constraining the contribution of Faraday rotation to two-point correlations of $B$-modes measured by Planck in 2015. Metric perturbations sourced by pri...

  20. The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles

    Science.gov (United States)

    Lim, Ai Khim; Lorthongpanich, Chanchao; Chew, Ting Gang; Tan, Chin Wee Godwin; Shue, Yan Ting; Balu, Sathish; Gounko, Natalia; Kuramochi-Miyagawa, Satomi; Matzuk, Martin M.; Chuma, Shinichiro; Messerschmidt, Daniel M.; Solter, Davor; Knowles, Barbara B.

    2013-01-01

    Mobilization of endogenous retrotransposons can destabilize the genome, an imminent danger during epigenetic reprogramming of cells in the germline. The P-element-induced wimpy testis (PIWI)-interacting RNA (piRNA) pathway is known to silence retrotransposons in the mouse testes. Several piRNA pathway components localize to the unique, germline structure known as the nuage. In this study, we surveyed mouse ovaries and found, for the first time, transient appearance of nuage-like structures in oocytes of primordial follicles. Mouse vasa homolog (MVH), Piwi-like 2 (PIWIL2/MILI) and tudor domain-containing 9 (TDRD9) are present in these structures, whereas aggregates of germ cell protein with ankyrin repeats, sterile alpha motif and leucine zipper (GASZ) localize separately in the cytoplasm. Retrotransposons are silenced in primordial ovarian follicles, and de-repressed upon reduction of piRNA expression in Mvh, Mili or Gasz mutants. However, these null-mutant females, unlike their male counterparts, are fertile, uncoupling retrotransposon activation from sterility. PMID:23924633

  1. Single field double inflation and primordial black holes

    Science.gov (United States)

    Kannike, K.; Marzola, L.; Raidal, M.; Veermäe, H.

    2017-09-01

    Within the framework of scalar-tensor theories, we study the conditions that allow single field inflation dynamics on small cosmological scales to significantly differ from that of the large scales probed by the observations of cosmic microwave background. The resulting single field double inflation scenario is characterised by two consequent inflation eras, usually separated by a period where the slow-roll approximation fails. At large field values the dynamics of the inflaton is dominated by the interplay between its non-minimal coupling to gravity and the radiative corrections to the inflaton self-coupling. For small field values the potential is, instead, dominated by a polynomial that results in a hilltop inflation. Without relying on the slow-roll approximation, which is invalidated by the appearance of the intermediate stage, we propose a concrete model that matches the current measurements of inflationary observables and employs the freedom granted by the framework on small cosmological scales to give rise to a sizeable population of primordial black holes generated by large curvature fluctuations. We find that these features generally require a potential with a local minimum. We show that the associated primordial black hole mass function is only approximately lognormal.

  2. New constraints on primordial gravitational waves from Planck 2015

    Science.gov (United States)

    Pagano, Luca; Salvati, Laura; Melchiorri, Alessandro

    2016-09-01

    We show that the new precise measurements of Cosmic Microwave Background (CMB) temperature and polarization anisotropies made by the Planck satellite significantly improves previous constraints on the cosmic gravitational waves background (CGWB) at frequencies f >10-15 Hz. On scales smaller than the horizon at the time of decoupling, primordial gravitational waves contribute to the total radiation content of the Universe. Considering adiabatic perturbations, CGWB affects temperature and polarization CMB power spectra and matter power spectrum in a manner identical to relativistic particles. Considering the latest Planck results we constrain the CGWB energy density to Ωgwh2 CMB power spectra with lensing, BAO and primordial Deuterium abundance observations, we obtain Ωgwh2 < 1.2 ×10-6 at 95% CL, improving previous Planck bounds by a factor 3 and the recent direct upper limit from the LIGO and VIRGO experiments a factor 2. A combined analysis of future satellite missions as COrE and EUCLID could improve current bound by more than an order of magnitude.

  3. Angular dependence of primordial trispectra and CMB spectral distortions

    Science.gov (United States)

    Shiraishi, Maresuke; Bartolo, Nicola; Liguori, Michele

    2016-10-01

    Under the presence of anisotropic sources in the inflationary era, the trispectrum of the primordial curvature perturbation has a very specific angular dependence between each wavevector that is distinguishable from the one encountered when only scalar fields are present, characterized by an angular dependence described by Legendre polynomials. We examine the imprints left by curvature trispectra on the TTμ bispectrum, generated by the correlation between temperature anisotropies (T) and chemical potential spectral distortions (μ) of the Cosmic Microwave Background (CMB). Due to the angular dependence of the primordial signal, the corresponding TTμ bispectrum strongly differs in shape from TTμ sourced by the usual gNL or τNL local trispectra, enabling us to obtain an unbiased estimation. From a Fisher matrix analysis, we find that, in a cosmic-variance-limited (CVL) survey of TTμ, a minimum detectable value of the quadrupolar Legendre coefficient is d2 ~ 0.01, which is 4 orders of magnitude better than the best value attainable from the TTTT CMB trispectrum. In the case of an anisotropic inflationary model with a f(phi)F2 interaction (coupling the inflaton field phi with a vector kinetic term F2), the size of the curvature trispectrum is related to that of quadrupolar power spectrum asymmetry, g*. In this case, a CVL measurement of TTμ makes it possible to measure g* down to 10‑3.

  4. Angular dependence of primordial trispectra and CMB spectral distortions

    CERN Document Server

    Shiraishi, Maresuke; Liguori, Michele

    2016-01-01

    Under the presence of anisotropic sources in the inflationary era, the trispectrum of the primordial curvature perturbation is sensitive to the angles between each wave vector. We examine the imprints left by curvature trispectra, in which the angular dependence is described by Legendre polynomials, on the $TT\\mu$ bispectrum, generated by the correlation between temperature anisotropies (T) and chemical potential spectral distortions ($\\mu$) of the Cosmic Microwave Background (CMB). Due to the angular dependence of the primordial signal, the corresponding $TT\\mu$ bispectrum strongly differs in shape from $TT\\mu$ sourced by the usual $g_{\\rm NL}$ or $\\tau_{\\rm NL}$ local trispectra, enabling us to obtain an unbiased estimation. From a Fisher matrix analysis, we find that, in a cosmic-variance-limited (CVL) survey of $TT\\mu$, a minimum detectable value of the quadrupolar Legendre coefficient is $d_2 \\sim 0.01$, which is 4 orders of magnitude better than the best value attainable from the $TTTT$ CMB trispectrum....

  5. Probing primordial non-Gaussianity consistency relation with galaxy surveys

    CERN Document Server

    Yamauchi, Daisuke

    2015-01-01

    With a radio continuum galaxy survey by Square Kilometre Array (SKA), a photometric galaxy survey by Euclid and their combination, we forecast future constraints on primordial non-Gaussianity. We focus on the potential impact of local-type higher-order nonlinear parameters on the parameter estimation and particularly the confirmation of the inflationary consistency inequality. Non-standard inflationary models, such as multi-field models, introduce the scale-dependent stochastic clustering of galaxies on large scales, which is a unique probe of mechanism for generating primordial density fluctuations. Our Fisher matrix analysis indicates that a deep and wide survey provided by SKA is more advantageous to constrain $\\tau_{\\rm NL}$, while Euclid has a strong constraining power for $f_{\\rm NL}$ due to the redshift information, suggesting that the joint analysis between them are quite essential to break the degeneracy between $f_{\\rm NL}$ and $\\tau_{\\rm NL}$. The combination of full SKA and Euclid will achieve the...

  6. Calculating the mass spectrum of primordial black holes

    CERN Document Server

    Young, Sam; Sasaki, Misao

    2014-01-01

    We reinspect the calculation for the mass fraction of primordial black holes (PBHs) which are formed from primordial perturbations, finding that performing the calculation using the comoving curvature perturbation $\\mathcal{R}_{c}$ in the standard way vastly overestimates the number of PBHs, by many orders of magnitude. This is because PBHs form shortly after horizon entry, meaning modes significantly larger than the PBH are unobservable and should not affect whether a PBH forms or not - this important effect is not taken into account by smoothing the distribution in the standard fashion. We discuss alternative methods and argue that the density contrast, $\\Delta$, should be used instead as super-horizon modes are damped by a factor $k^{2}$. We make a comparison between using a Press-Schechter approach and peaks theory, finding that the two are in close agreement in the region of interest. We also investigate the effect of varying the spectral index, and the running of the spectral index, on the abundance of ...

  7. New constraints on primordial gravitational waves from Planck 2015

    CERN Document Server

    Pagano, Luca; Melchiorri, Alessandro

    2015-01-01

    We show that the new precise measurements of Cosmic Microwave Background (CMB) temperature and polarization anisotropies made by the Planck satellite significantly improves previous constraints on the cosmic gravitational waves background (CGWB) at frequencies $f>10^{-15}$ Hz. On scales smaller than the comoving horizon at the time of decoupling, primordial gravitational waves contribute to the total radiation content of the Universe. Considering adiabatic perturbations, CGWB affects temperature and polarization CMB power spectra and matter power spectrum in a manner identical to relativistic particles. Considering the latest Planck results we constrain the CGWB energy density to $\\Omega_{\\rm gw} h^2 <2.5\\times 10^{-6} $ at 95\\% c.l. Combining CMB power spectra with lensing, BAO and primordial Deuterium abundance observations, we obtain $\\Omega_{\\rm gw} h^2 <1.7\\times 10^{-6} $ at 95\\% c.l., improving previous cosmological bounds by a factor 5 and the recent direct upper limit from the LIGO and VIRGO ex...

  8. Planck 2013 Results. XXIV. Constraints on primordial non-Gaussianity

    CERN Document Server

    Ade, P.A.R.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Banday, A.J.; Barreiro, R.B.; Bartlett, J.G.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoit, A.; Benoit-Levy, A.; Bernard, J.P.; Bersanelli, M.; Bielewicz, P.; Bobin, J.; Bock, J.J.; Bonaldi, A.; Bonavera, L.; Bond, J.R.; Borrill, J.; Bouchet, F.R.; Bridges, M.; Bucher, M.; Burigana, C.; Butler, R.C.; Cardoso, J.F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, L.Y.; Chiang, H.C.; Christensen, P.R.; Church, S.; Clements, D.L.; Colombi, S.; Colombo, L.P.L.; Couchot, F.; Coulais, A.; Crill, B.P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R.D.; Davis, R.J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.M.; Desert, F.X.; Diego, J.M.; Dole, H.; Donzelli, S.; Dore, O.; Douspis, M.; Ducout, A.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Elsner, F.; Ensslin, T.A.; Eriksen, H.K.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Franceschi, E.; Galeotta, S.; Ganga, K.; Giard, M.; Giraud-Heraud, Y.; Gonzalez-Nuevo, J.; Gorski, K.M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Hansen, F.K.; Hanson, D.; Harrison, D.; Heavens, A.; Henrot-Versille, S.; Hernandez-Monteagudo, C.; Herranz, D.; Hildebrandt, S.R.; Hivon, E.; Hobson, M.; Holmes, W.A.; Hornstrup, A.; Hovest, W.; Huffenberger, K.M.; Jaffe, T.R.; Jaffe, A.H.; Jones, W.C.; Juvela, M.; Keihanen, E.; Keskitalo, R.; Kisner, T.S.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lacasa, F.; Lagache, G.; Lahteenmaki, A.; Lamarre, J.M.; Lasenby, A.; Laureijs, R.J.; Lawrence, C.R.; Leahy, J.P.; Leonardi, R.; Lesgourgues, J.; Lewis, A.; Liguori, M.; Lilje, P.B.; Linden-Vornle, M.; Lopez-Caniego, M.; Lubin, P.M.; Macias-Perez, J.F.; Maffei, B.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marinucci, D.; Maris, M.; Marshall, D.J.; Martin, P.G.; Martinez-Gonzalez, E.; Masi, S.; Matarrese, S.; Matthai, F.; Mazzotta, P.; Meinhold, P.R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschenes, M.A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Naselsky, P.; Natoli, P.; Netterfield, C.B.; Norgaard-Nielsen, H.U.; Noviello, F.; Novikov, D.; Novikov, I.; Osborne, S.; Oxborrow, C.A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Peiris, H.V.; Perdereau, O.; Perotto, L.; Perrotta, F.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G.W.; Prezeau, G.; Prunet, S.; Puget, J.L.; Rachen, J.P.; Racine, B.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Roudier, G.; Rubino-Martin, J.A.; Rusholme, B.; Sandri, M.; Santos, D.; Savini, G.; Scott, D.; Seiffert, M.D.; Shellard, E.P.S.; Smith, K.; Spencer, L.D.; Starck, J.L.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sureau, F.; Sutton, D.; Suur-Uski, A.S.; Sygnet, J.F.; Tauber, J.A.; Tavagnacco, D.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Varis, J.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L.A.; Wandelt, B.D.; White, M.; White, S.D.M.; Yvon, D.; Zacchei, A.; Zonca, A.

    2014-01-01

    The Planck nominal mission cosmic microwave background (CMB) maps yield unprecedented constraints on primordial non-Gaussianity (NG). Using three optimal bispectrum estimators, separable template-fitting (KSW), binned, and modal, we obtain consistent values for the primordial local, equilateral, and orthogonal bispectrum amplitudes, quoting as our final result fNL^local= 2.7+/-5.8, fNL^equil= -42+/-75, and fNL^ortho= -25+\\-39 (68% CL statistical). NG is detected in the data; using skew-C_l statistics we find a nonzero bispectrum from residual point sources, and the ISW-lensing bispectrum at a level expected in the LambdaCDM scenario. The results are based on comprehensive cross-validation of these estimators on Gaussian and non-Gaussian simulations, are stable across component separation techniques, pass an extensive suite of tests, and are confirmed by skew-C_l, wavelet bispectrum and Minkowski functional estimators. Beyond estimates of individual shape amplitudes, we present model-independent, 3-dimensional...

  9. Non-standard primordial fluctuations and nongaussianity in string inflation

    Energy Technology Data Exchange (ETDEWEB)

    Burgess, C.P. [McMaster Univ., Hamilton, ON (Canada). Dept. of Physics and Astronomy; Perimeter Institute for Theoretical Physics, Waterloo, ON (Canada); Cicoli, M. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Gomez-Reino, M. [CERN, Geneve (Switzerland). Theory Div.; Oviedo Univ. (Spain). Dept. of Physics; Quevedo, F. [Cambridge Univ. (United Kingdom). DAMTP/CMS; Abdus Salam ICTP, Trieste (Italy); Tasinato, G. [Heidelberg Univ. (Germany). Inst. fuer Theoretische Physik; Zavala, I. [Bonn Univ. (Germany). Bethe Center for Theoretical Physics and Physikalisches Inst.

    2010-05-15

    Inflationary scenarios in string theory often involve a large number of light scalar fields, whose presence can enrich the post-inflationary evolution of primordial fluctuations generated during the inflationary epoch. We provide a simple example of such post-inflationary processing within an explicit string-inflationary construction, using a Kaehler modulus as the inflaton within the framework of LARGE Volume Type-IIB string flux compactifications. We argue that inflationary models within this broad category often have a selection of scalars that are light enough to be cosmologically relevant, whose contributions to the primordial fluctuation spectrum can compete with those generated in the standard way by the inflaton. These models consequently often predict nongaussianity at a level, f{sub NL}{approx_equal}O(10), potentially observable by the Planck satellite, with a bi-spectrum maximized by triangles with squeezed shape in a string realization of the curvaton scenario. We argue that the observation of such a signal would robustly prefer string cosmologies such as these that predict a multi-field dynamics during the very early universe. (orig.)

  10. Deciphering primordial cyanobacterial genome functions from protein network analysis.

    Science.gov (United States)

    Harel, Arye; Karkar, Slim; Cheng, Shu; Falkowski, Paul G; Bhattacharya, Debashish

    2015-03-02

    The Great Oxidation Event (GOE) ∼2.4 billion years ago resulted from the accumulation of oxygen by the ancestors of cyanobacteria [1-3]. Cyanobacteria continue to play a significant role in primary production [4] and in regulating the global marine and limnic nitrogen cycles [5, 6]. Relatively little is known, however, about the evolutionary history and gene content of primordial cyanobacteria [7, 8]. To address these issues, we used protein similarity networks [9], containing proteomes from 48 cyanobacteria as the test group, and reference proteomes from 84 microbes representing four distinct metabolic groups from most reducing to most oxidizing: methanogens, obligate anaerobes (nonmethanogenic), facultative aerobes, and obligate aerobes. These four metabolic groups represent extant bioinformatic proxies for ancient redox chemistries, extending from an anoxic origin through the GOE and ultimately to obligate aerobes [10-13]. Analysis of the network metric degree showed a strong relationship between cyanobacteria and obligate anaerobes, from which cyanobacteria presumably arose, for core functions that include translation, photosynthesis, energy conservation, and environmental interactions. These data were used to reconstruct primordial functions in cyanobacteria that included nine gene families involved in photosynthesis, hydrogenases, and proteins involved in defense from environmental stress. The presence of 60% of these genes in both reaction center I (RC-I) and RC-II-type bacteria may be explained by selective loss of either RC in the evolutionary history of some photosynthetic lineages. Finally, the network reveals that cyanobacteria occupy a unique position among prokaryotes as a hub between anaerobes and obligate aerobes.

  11. Measuring primordial non-Gaussianity with weak-lensing surveys

    CERN Document Server

    Hilbert, Stefan; Smith, Robert E; Desjacques, Vincent

    2012-01-01

    We study the ability of future weak lensing (WL) surveys to constrain primordial non-Gaussianity of the local type. We use a large ensemble of simulated WL maps with survey specifications relevant to Euclid and LSST. The simulations assume Cold Dark Matter cosmologies that vary certain parameters around fiducial values: the non-Gaussianity parameter f_NL, the matter density parameter Omega_m, the amplitude of the matter power spectrum sigma_8, the spectral index of the primordial power spectrum n_s, and the dark-energy equation-of-state parameter w_0. We assess the sensitivity of the cosmic shear correlation functions, the third-order aperture mass statistics, and the abundance of shear peaks to these parameters. We find that each of the considered probes provides unmarginalized constraints of Delta f_NL ~ 20 on f_NL. Marginalized constraints from any individual WL probe are much weaker due to strong correlations between parameters. However, the parameter errors can be substantially reduced by combining infor...

  12. Primordial Molecular Cloud Material in Metal-Rich Carbonaceous Chondrites

    Science.gov (United States)

    Taylor, G. J.

    2016-03-01

    The menagerie of objects that make up our Solar System reflects the composition of the huge molecular cloud in which the Sun formed, a late addition of short-lived isotopes from an exploding supernova or stellar winds from a neighboring massive star, heating and/or alteration by water in growing planetesimals that modified and segregated the primordial components, and mixing throughout the Solar System. Outer Solar System objects, such as comets, have always been cold, hence minimizing the changes experienced by more processed objects. They are thought to preserve information about the molecular cloud. Elishevah Van Kooten (Natural History Museum of Denmark and the University of Copenhagen) and co-authors in Denmark and at the University of Hawai'i, measured the isotopic compositions of magnesium and chromium in metal-rich carbonaceous chondrites. They found that the meteorites preserve an isotopic signature of primordial molecular cloud materials, providing a potentially detailed record of the molecular cloud's composition and of materials that formed in the outer Solar System.

  13. Inhibitory actions of Anti-Müllerian Hormone (AMH) on ovarian primordial follicle assembly.

    Science.gov (United States)

    Nilsson, Eric E; Schindler, Ryan; Savenkova, Marina I; Skinner, Michael K

    2011-01-01

    The current study was designed to investigate the actions of Anti-Müllerian Hormone (AMH) on primordial follicle assembly. Ovarian primordial follicles develop from the breakdown of oocyte nests during fetal development for the human and immediately after birth in rodents. AMH was found to inhibit primordial follicle assembly and decrease the initial primordial follicle pool size in a rat ovarian organ culture. The AMH expression was found to be primarily in the stromal tissue of the ovaries at this period of development, suggesting a stromal-epithelial cell interaction for primordial follicle assembly. AMH was found to promote alterations in the ovarian transcriptome during primordial follicle assembly with over 200 genes with altered expression. A gene network was identified suggesting a potential central role for the Fgf2/Nudt6 antisense transcript in the follicle assembly process. A number of signal transduction pathways are regulated by AMH actions on the ovarian transcriptome, in particular the transforming growth factor-beta (TGFß) signaling process. AMH is the first hormone/protein shown to have an inhibitory action on primordial follicle assembly. Due to the critical role of the primordial follicle pool size for female reproduction, elucidation of factors, such as AMH, that regulate the assembly process will provide insights into potential therapeutics to manipulate the pool size and female reproduction.

  14. Effect of gonadotropin-releasing hormone antagonist on primordial follicle survival in the primate ovary.

    Science.gov (United States)

    Attaman, Jill; Arbogast, Laura K; Friedman, Chad I; Danforth, Douglas R

    2014-01-01

    To examine the effects of gonadotropin-releasing hormone (GnRH) antagonist on primordial follicle reserve in the primate ovary. A prospective basic research study in which 10 juvenile cynomolgus monkeys (Macaca fascicularis) had 1 ovary surgically removed. Six animals were then treated with the GnRH antagonist antide (1.0 mg/kg/day) for 14 days, and 4 animals were treated with vehicle. After treatment the contralateral ovary was removed and both ovaries were prepared for assessment of primordial, primary, and secondary follicle numbers. Antide treatment resulted in a modest (13%) but significant decrease in primordial follicle number in juvenile macaques (p = 0.048, n = 6). Three animals demonstrated a marked reduction in primordial follicles (19%, 25%, 36%) and 3 animals had no (primordial follicles after antide treatment. Control animals demonstrated no change in primordial follicle number following vehicle treatment. Antide had no effect on primary, secondary, or early antral follicle numbers and did not affect circulating estradiol concentrations. In contrast to mice, in which GnRH antagonist treatment markedly reduces primordial follicle reserve, the effect of antide in nonhuman primates was less dramatic and somewhat variable. These data suggest there may be a subset of animals susceptible to the adverse effects of GnRH antagonist on primordial follicle survival.

  15. Modification of the halo mass function by kurtosis associated with primordial non-Gaussianity

    NARCIS (Netherlands)

    Yokoyama, Shuichiro; Sugiyama, Naoshi; Zaroubi, Saleem; Silk, Joseph

    2011-01-01

    We study the halo mass function in the presence of a kurtosis type of primordial non-Gaussianity. The kurtosis corresponds to the trispectrum as defined in Fourier space. The primordial trispectrum is commonly characterized by two parameters, tNL and gNL. We focus on tNL which is an important

  16. Ultrastructure of sheep primordial follicles cultured in the presence of indol acetic acid, EGF, and FSH

    DEFF Research Database (Denmark)

    Andrade, Evelyn Rabelo; Hyttel, Poul; Landim-Alvarenga, Fernanda Da Cruz;

    2011-01-01

    The aim of this study was to investigate the ultrastructural characteristics of primordial follicles after culturing of sheep ovarian cortical slices in the presence of indol acetic acid (IAA), Epidermal Growth Factor (EGF), and FSH. To evaluate ultrastructure of primordial follicles cultured...

  17. Inhibitory actions of Anti-Mullerian Hormone (AMH on ovarian primordial follicle assembly.

    Directory of Open Access Journals (Sweden)

    Eric E Nilsson

    Full Text Available The current study was designed to investigate the actions of Anti-Müllerian Hormone (AMH on primordial follicle assembly. Ovarian primordial follicles develop from the breakdown of oocyte nests during fetal development for the human and immediately after birth in rodents. AMH was found to inhibit primordial follicle assembly and decrease the initial primordial follicle pool size in a rat ovarian organ culture. The AMH expression was found to be primarily in the stromal tissue of the ovaries at this period of development, suggesting a stromal-epithelial cell interaction for primordial follicle assembly. AMH was found to promote alterations in the ovarian transcriptome during primordial follicle assembly with over 200 genes with altered expression. A gene network was identified suggesting a potential central role for the Fgf2/Nudt6 antisense transcript in the follicle assembly process. A number of signal transduction pathways are regulated by AMH actions on the ovarian transcriptome, in particular the transforming growth factor-beta (TGFß signaling process. AMH is the first hormone/protein shown to have an inhibitory action on primordial follicle assembly. Due to the critical role of the primordial follicle pool size for female reproduction, elucidation of factors, such as AMH, that regulate the assembly process will provide insights into potential therapeutics to manipulate the pool size and female reproduction.

  18. Primordial follicle assembly was regulated by Notch signaling pathway in the mice.

    Science.gov (United States)

    Chen, Chun-Lei; Fu, Xia-Fei; Wang, Lin-Qing; Wang, Jun-Jie; Ma, Hua-Gang; Cheng, Shun-Feng; Hou, Zhu-Mei; Ma, Jin-Mei; Quan, Guo-Bo; Shen, Wei; Li, Lan

    2014-03-01

    Notch signaling pathway, a highly conserved cell signaling system, exists in most multicellular organisms. The objective of this study was to examine Notch signaling pathway in germ cell cyst breakdown and primordial follicle formation. The receptor and ligand genes of Notch pathway (Notch1, Notch2, Jagged1, Jagged2 and Hes1) were extremely down-regulated after newborn mouse ovaries were cultured then exposed to DAPT or L-685,458 in vitro (P primordial follicles. Down-regulated mRNA expression of specific genes including Lhx8, Figla, Sohlh2 and Nobox, were also observed. The percentages of female germ cells in germ cell cysts and primordial follicles were counted after culture of newborn ovaries for 3 days in vitro. The result showed female germ cells in cysts was remarkably up-regulated while as the oocytes in primordial follicles was significantly down-regulated (P primordial follicle in mice.

  19. Inhibition of primordial germ cell proliferation by the medaka male determining gene Dmrt1bY

    Directory of Open Access Journals (Sweden)

    Hornung Ute

    2007-08-01

    Full Text Available Abstract Background Dmrt1 is a highly conserved gene involved in the determination and early differentiation phase of the primordial gonad in vertebrates. In the fish medaka dmrt1bY, a functional duplicate of the autosomal dmrt1a gene on the Y-chromosome, has been shown to be the master regulator of male gonadal development, comparable to Sry in mammals. In males mRNA and protein expression was observed before morphological sex differentiation in the somatic cells surrounding primordial germ cells (PGCs of the gonadal anlage and later on exclusively in Sertoli cells. This suggested a role for dmrt1bY during male gonad and germ cell development. Results We provide functional evidence that expression of dmrt1bY leads to negative regulation of PGC proliferation. Flow cytometric measurements revealed a G2 arrest of dmrt1bY expressing cells. Interestingly, also non-transfected cells displayed a significantly lower fraction of proliferating cells, pointing to a possible non-cell autonomous action of dmrt1bY. Injection of antisense morpholinos led to an increase of PGCs in genetically male embryos due to loss of proliferation inhibition. Conclusion In medaka, dmrt1bY mediates a mitotic arrest of PGCs in males prior to testes differentiation at the sex determination stage. This occurs possibly via a cross-talk of Sertoli cells and PGCs.

  20. p27(Kip1) negatively regulates the activation of murine primordial oocytes.

    Science.gov (United States)

    Hirashima, Yumiko; Moniruzzaman, Mohammad; Miyano, Takashi

    2011-04-01

    In mice, small oocytes (primordial oocytes) are enclosed within flattened granulosa cells to form primordial follicles around birth. A small number of primordial oocytes enter the growth phase, whereas others are quiescent. The mechanism regulating this selection of primordial oocytes is not well understood. The objective of the present study was to understand the role of p27(Kip1), which regulates cell cycle progression in somatic cells, in the growth initiation of primordial oocytes in neonatal mice. We studied the localization of p27(Kip1) in 0-, 3-, 5-, 7- and 21-day-old mouse ovaries by immunohistochemistry. Ovaries from 3-day-old mice were treated with p27(Kip1) siRNAs (small interfering RNAs), and knockdown of p27(Kip1) was determined by immunohistochemistry and Western blotting. Ovaries treated with siRNAs were organ-cultured for 6 days, and oocyte growth was estimated histologically. Expression of p27(Kip1) was undetectable in the primordial oocytes of newborn mice. In the 3-day-old ovaries (n=3), p27(Kip1) was demonstrated in the nucleus of 36 ± 6% primordial oocytes. The percentage of p27(Kip1)-positive primordial oocytes increased to 72 ± 8 (n=3), 85 ± 7 (n=3) and 93 ± 5 (n=3) in the 5-, 7- and 21-day-old mouse ovaries, respectively. After knockdown of the p27(Kip1) protein by siRNAs, a higher proportion of oocytes entered the growth phase in cultured ovaries than those in the control. These results suggest that p27(Kip1) negatively regulates primordial oocyte growth and that knockdown of p27(Kip1) leads primordial oocytes to enter the growth phase in vitro.

  1. Putative archaeal viruses from the mesopelagic ocean.

    Science.gov (United States)

    Vik, Dean R; Roux, Simon; Brum, Jennifer R; Bolduc, Ben; Emerson, Joanne B; Padilla, Cory C; Stewart, Frank J; Sullivan, Matthew B

    2017-01-01

    Oceanic viruses that infect bacteria, or phages, are known to modulate host diversity, metabolisms, and biogeochemical cycling, while the viruses that infect marine Archaea remain understudied despite the critical ecosystem roles played by their hosts. Here we introduce "MArVD", for Metagenomic Archaeal Virus Detector, an annotation tool designed to identify putative archaeal virus contigs in metagenomic datasets. MArVD is made publicly available through the online iVirus analytical platform. Benchmarking analysis of MArVD showed it to be >99% accurate and 100% sensitive in identifying the 127 known archaeal viruses among the 12,499 viruses in the VirSorter curated dataset. Application of MArVD to 10 viral metagenomes from two depth profiles in the Eastern Tropical North Pacific (ETNP) oxygen minimum zone revealed 43 new putative archaeal virus genomes and large genome fragments ranging in size from 10 to 31 kb. Network-based classifications, which were consistent with marker gene phylogenies where available, suggested that these putative archaeal virus contigs represented six novel candidate genera. Ecological analyses, via fragment recruitment and ordination, revealed that the diversity and relative abundances of these putative archaeal viruses were correlated with oxygen concentration and temperature along two OMZ-spanning depth profiles, presumably due to structuring of the host Archaea community. Peak viral diversity and abundances were found in surface waters, where Thermoplasmata 16S rRNA genes are prevalent, suggesting these archaea as hosts in the surface habitats. Together these findings provide a baseline for identifying archaeal viruses in sequence datasets, and an initial picture of the ecology of such viruses in non-extreme environments.

  2. Signatures of the primordial Universe from its emptiness

    CERN Document Server

    Kitaura, Francisco-Shu; Liang, Yu; Zhao, Cheng; Tao, Charling; Rodriguez-Torres, Sergio; Eisenstein, Daniel J; Gil-Marin, Hector; Kneib, Jean-Paul; McBride, Cameron; Percival, Will; Ross, Ashley J; Sanchez, Ariel G; Tinker, Jeremy; Tojeiro, Rita; Vargas-Magana, Mariana; Zhao, Gong-Bo

    2015-01-01

    Sound waves from the primordial fluctuations of the Universe imprinted in the large-scale structure, called baryon acoustic oscillations (BAOs), can be used as standard rulers to measure the scale of the Universe. These oscillations have already been detected in the distribution of galaxies. Here we propose to measure BAOs from the troughs (minima) of the density field. Based on two sets of accurate mock halo catalogues with and without BAOs in the seed initial conditions, we demonstrate that the BAO signal cannot be obtained from the clustering of classical disjoint voids, but is clearly detected from overlapping voids. The latter represent an estimate of all troughs of the density field. We compute them from the empty circumspheres centres constrained by tetrahedra of galaxies using Delaunay triangulation. Our theoretical models based on an unprecedented large set of detailed simulated void catalogues are remarkably well confirmed by observational data. We use the largest recently publicly available sample ...

  3. Primordial Trispectrum from Entropy Perturbations in Multifield DBI Model

    CERN Document Server

    Gao, Xian

    2009-01-01

    We compute the leading-order contributions to the trispectrum of primordial curvature perturbation from the entropic modes in multifield DBI inflationary models. We focus on the case from exchanging one mode. We investigate four-point functions for entropy fluctuations, in which four external entropic modes exchange one adiabatic mode. In the limit of small sound speed ($c_s\\ll1$) and large transfer coefficient ($T_{\\textrm{RS}}\\gg1$), our result shows that the nonlinear parameter $\\tau_{NL}$ is of order $T^{-2}_{RS}c^{-4}_s$ in the equilateral configuration. This result implies that trispectrum from exchanging one mode is approximately the same order as from direct four-point interaction in single-field models $c^{-4}_s$, but suppressed by the large transfer coefficient $T_{\\textrm{RS}}$.

  4. Constraining CMB-consistent primordial voids with cluster evolution

    CERN Document Server

    Mathis, H; Griffiths, L M; Kunz, M

    2004-01-01

    Using cosmological simulations, we make predictions for the distribution of clusters in a plausible non-gaussian model where primordial voids nucleated during inflation act together with scale-invariant adiabatic gaussian fluctuations as seeds for the formation of large-scale structure. This model agrees with most recent observations of the anisotropies of the cosmic microwave background (CMB) and can account for the excess of power measured on cluster scales by the Cosmic Background Imager (CBI), the large empty regions apparent in nearby galaxy redshift surveys and the number of giant arcs measured in deep cluster lensing surveys. We show that the z=0 cluster mass function differs from predictions for a standard LCDM cosmology with the same sigma_8. Moreover, as massive clusters also form much earlier in the "void" scenario, we show that integrated number counts of SZ sources and simple statistics of strong lensing can easily falsify this model.

  5. Primordial Black Holes from Supersymmetry in the Early Universe

    Science.gov (United States)

    Cotner, Eric; Kusenko, Alexander

    2017-07-01

    Supersymmetric extensions of the standard model generically predict that in the early Universe a scalar condensate can form and fragment into Q balls before decaying. If the Q balls dominate the energy density for some period of time, the relatively large fluctuations in their number density can lead to formation of primordial black holes (PBH). Other scalar fields, unrelated to supersymmetry, can play a similar role. For a general charged scalar field, this robust mechanism can generate black holes over the entire mass range allowed by observational constraints, with a sufficient abundance to account for all dark matter in some parameter ranges. In the case of supersymmetry the mass range is limited from above by 1 023 g . We also comment on the role that topological defects can play for PBH formation in a similar fashion.

  6. Random-walk baryogenesis via primordial black holes

    CERN Document Server

    Semiz, İbrahim

    2016-01-01

    Gravitation violates baryon number $B$: A star has a huge amount of it, while a black hole forming from the star has none. Consider primordial black holes before the hadronic annihiliation in the early universe, encountering and absorbing baryons and antibaryons: Each such absorption changes $B$ of the universe by one unit, up or down. But the absorption events are $uncorrelated$ $and$ $random$, hence they amount to a random walk in $B$-space, leading to the expectation of a net $|B|$ at the end. While the scale of this effect is most uncertain, it must exist. We explore some ramifications, including the change of net $|B|$ with expansion, connection with universe topology, and possible observational signatures.

  7. Primordial black hole constraints for extended mass functions

    Science.gov (United States)

    Carr, Bernard; Raidal, Martti; Tenkanen, Tommi; Vaskonen, Ville; Veermäe, Hardi

    2017-07-01

    We revisit the cosmological and astrophysical constraints on the fraction of the dark matter in primordial black holes (PBHs) with an extended mass function. We consider a variety of mass functions, all of which are described by three parameters: a characteristic mass and width and a dark matter fraction. Various observations then impose constraints on the dark matter fraction as a function of the first two parameters. We show how these constraints relate to those for a monochromatic mass function, demonstrating that they usually become more stringent in the extended case than the monochromatic one. Considering only the well-established bounds, and neglecting the ones that depend on additional astrophysical assumptions, we find that there are three mass windows, around 5 ×10-16M⊙ , 2 ×10-14M⊙ and 25 - 100 M⊙ , where PBHs can constitute all the dark matter. However, if one includes all the bounds, PBHs can only constitute of order 10% of the dark matter.

  8. Primordial power spectra for scalar perturbations in loop quantum cosmology

    CERN Document Server

    de Blas, Daniel Martín

    2016-01-01

    We provide the power spectrum of small scalar perturbations propagating in an inflationary scenario within loop quantum cosmology. We consider the hybrid quantization approach applied to a Friedmann--Robertson--Walker spacetime with flat spatial sections coupled to a massive scalar field. We study the quantum dynamics of scalar perturbations on an effective background within this hybrid approach. We consider in our study adiabatic states of different orders. For them, we find that the hybrid quantization is in good agreement with the predictions of the dressed metric approach. We also propose an initial vacuum state for the perturbations, and compute the primordial and the anisotropy power spectrum in order to qualitatively compare with the current observations of Planck mission. We find that our vacuum state is in good agreement with them, showing a suppression of the power spectrum for large scale anisotropies. We compare with other choices already studied in the literature.

  9. Nuclear Physics Solutions to the Primordial Lithium Problem

    Directory of Open Access Journals (Sweden)

    Williams E.

    2012-10-01

    Full Text Available The primordial lithium problem is one of the major outstanding issues in the standard model of the Big Bang. Measurements of the baryon to photon ratio in the cosmic microwave background constrain model predictions, giving abundances of 7Li two to four times larger than observed via spectroscopic measurements of metal-poor stars. In an attempt to reconcile this discrepancy, significant effort has been directed at measuring reaction cross sections of light nuclei at astrophysically relevant energies. However, there remain reaction cross sections with large uncertainties, and some that have not yet been measured. Particularly relevant are those involving the destruction of 7Be, a progenitor of 7Li. Key issues that can be improved by nuclear physics input will be highlighted, and the applicability of detectors and event reconstruction techniques recently developed at the ANU will be discussed.

  10. The Divergence and Natural Selection of Autocatalytic Primordial Metabolic Systems

    Science.gov (United States)

    Marakushev, Sergey A.; Belonogova, Ol'ga V.

    2013-06-01

    The diversity of the central metabolism of modern organisms is caused by the existence of a few metabolic modules, combination of which produces multiple metabolic pathways. This paper analyzes biomimetically reconstructed coupled autocatalytic cycles as the basis of ancestral metabolic systems. The mechanism for natural selection and evolution in autocatalytic chemical systems may be affected by natural homeostatic parameters such as ambient chemical potentials, temperature, and pressure. Competition between separate parts of an autocatalytic network with positive-plus-negative feedback resulted in the formation of primordial autotrophic, mixotrophic, and heterotrophic metabolic systems. This work examined the last common ancestor of a set of coupled metabolic cycles in a population of protocells. Physical-chemical properties of these cycles determined the main principles of natural selection for the ancestral Bacteria and Archaea taxa.

  11. Fluctuations in the relativistic plasma and primordial magnetic fields

    Energy Technology Data Exchange (ETDEWEB)

    Lemoine, D. (Institut d' Astrophysique de Paris, CNRS, 98bis Bd Arago, F-75014 Paris (France) DAEC, Observatoire de Paris, Universite Paris VII, CNRS (UA173), F-92195 Meudon Cedex (France))

    1995-03-15

    The stochastic fluctuations of the electromagnetic field in a relativistic electron-positron plasma are studied. The correlation functions of the fluctuating four-current, electric and magnetic fields are computed to leading order using the Schwinger-Keldysh closed time path formulation of thermal field theory. As an application, we consider the scenario proposed by Tajima [ital et] [ital al]. for generating a primordial magnetic field from thermal fluctuations in the prerecombination plasma. We compute the level of magnetic fluctuations sustained by the pair plasma at or before the epoch of big bang nucleosynthesis and conclude that the early Universe was pervaded by a strong low-frequency, albeit small-scale, random magnetic field. The astrophysical implications are briefly discussed.

  12. Primordial black hole formation from non-Gaussian curvature perturbations

    CERN Document Server

    Klimai, P A

    2012-01-01

    We consider several early Universe models that allow for production of large curvature perturbations at small scales. As is well known, such perturbations can lead to production of primordial black holes (PBHs). We briefly review the Gaussian case and then focus on two models which produce strongly non-Gaussian perturbations: hybrid inflation waterfall model and the curvaton model. We show that limits on the values of curvature perturbation power spectrum amplitude are strongly dependent on the shape of perturbations and can significantly (by two orders of magnitude) deviate from the usual Gaussian limit of ${\\cal P}_\\zeta \\lesssim 10^{-2}$. We give examples of PBH mass spectra calculations for each case.

  13. Primordial heavy elements in composite dark matter models

    CERN Document Server

    Khlopov, M Yu

    2008-01-01

    A widely accepted viewpoint is to consider candidates for cosmological dark matter as neutral and weakly interacting particles, as well as to consider only light elements in the pregalactic chemical composition. It is shown that stable charged leptons and quarks can exist and, hidden in elusive atoms, play the role of dark matter. The inevitable consequence of realistic scenarios with such composite atom-like dark matter is existence of significant or even dominant fraction of "atoms", binding heavy -2 charged particles and He-4 nuclei. Being alpha-particles with shielded electric charge, such atoms catalyse a new path of nuclear transformations in the period of Big Bang Nucleosynthesis, which result in primordial heavy elements. The arguments are given, why such scenario escapes immediate contradiction with observations and challenges search for heavy stable charged particles in cosmic rays and at accelerators.

  14. The Burst Mode of Accretion in Primordial Protostars

    CERN Document Server

    Vorobyov, Eduard I; Basu, Shantanu

    2013-01-01

    We study the formation and long-term evolution of primordial protostellar disks harbored by first stars using numerical hydrodynamics simulations in the thin-disk limit. The initial conditions are specified by pre-stellar cores with distinct mass, angular momentum, and temperature. This allows us to probe several tens of thousand years of the disk's initial evolution, during which we observe multiple episodes of fragmentation leading to the formation of gravitationally bound gaseous clumps within spiral arms. These fragments are torqued inward due to gravitational interaction with the spiral arms on timescales of 10^3 - 10^4 yr and accreted onto the growing protostar, giving rise to accretion and luminosity bursts. The burst phenomenon is fueled by continuing accretion of material falling onto the disk from the collapsing parent core, which replenishes the mass lost by the disk due to accretion, and triggers repetitive episodes of disk fragmentation. We show that the burst phenomenon is expected to occur for ...

  15. The quantum-to-classical transition of primordial cosmological perturbations

    CERN Document Server

    Pinto-Neto, Nelson; Struyve, Ward

    2011-01-01

    There is a widespread belief that the classical small inhomogeneities which gave rise to all structures in the Universe through gravitational instability originated from primordial quantum cosmological fluctuations. However, this transition from quantum to classical fluctuations is plagued with important conceptual issues, most of them related to the application of standard quantum theory to the Universe as a whole. In this paper, we show how these issues can easily be overcome in the framework of the de Broglie-Bohm quantum theory. This theory is an alternative to standard quantum theory that provides an objective description of physical reality, where rather ambiguous notions of measurement or observer play no fundamental role, and which can hence be applied to the Universe as a whole. In addition, it allows for a simple and unambiguous characterization of the classical limit.

  16. Evolution of Primordial Protostellar Clouds Quasi-Static Analysis

    CERN Document Server

    Omukai, K; Uehara, H; Susa, H; Omukai, Kazuyuki; Nishi, Ryoichi; Uehara, Hideya; Susa, Hajime

    1998-01-01

    The contraction processes of metal-free molecular clouds of starlike mass (or cloud cores) are investigated. We calculate radiative transfer of the H_2 lines and examine quasi-static contraction with radiative cooling. Comparing two time-scales, the free-fall time t_ff and the time-scale of quasi-static contraction t_qsc (nearly equal to t_cool, the cooling time) of these cores, we find that the ratio of the two time-scales t_ff/t_qsc, i.e., the efficiency of cooling, becomes larger with contraction even under the existence of cold and opaque envelopes. In particular, for fragments of primordial filamentary clouds, for which t_ff is nearly equal to t_qsc at the fragmentation epoch, they collapse dynamically in the free-fall time-scale. This efficiency of cooling is unique to line cooling.

  17. Contribution of HD molecules in cooling of the primordial gas

    CERN Document Server

    Vasiliev, E O; Shchekinov, Yu. A.

    2005-01-01

    We study the effects of HD molecules on thermochemical evolution of the primordial gas behind shock waves, possibly arised in the process of galaxy formation. We find the critical shock velocity when deuterium transforms efficiently into HD molecules which then dominate gas cooling. Above this velocity the shocked gas is able to cool down to the temperature of the cosmic microwave background. Under these conditions the corresponding Jeans mass depends only on redshift and initial density of baryons $M_J \\propto \\delta_c^{-0.5} (1+z)^{0.5}$. At $z\\simgt 45$ HD molecules heat shocked gas, and at larger redshift their contribution to thermal evolution becomes negligible.

  18. Primordial GWs from universality classes of pseudo-scalar inflation

    Science.gov (United States)

    Pieroni, M.

    2017-05-01

    In this contribution we discuss the possibility of generating an observable gravitational wave (GW) background by coupling a pseudo-scalar inflaton to some Abelian gauge fields. This analysis is performed by dividing inflationary models into universality classes. We find that of the most promising scenario is a Starobinsky-like model, which may lead to the generation of observational signatures both in upcoming CMB detectors as well as for direct GW detectors. The signal which can be produced in these models would both be observable in ground-based detectors, such as advanced LIGO, and in space-based detectors, such as LISA. The complementarity between the CMB and direct GW detection may be used to extract informations on the microphysics of inflation. Interestingly the mechanism discussed in this contribution may also be relevant for the generation of Primordial Black Holes (PBHs).

  19. Primordial Black Holes from Supersymmetry in the Early Universe.

    Science.gov (United States)

    Cotner, Eric; Kusenko, Alexander

    2017-07-21

    Supersymmetric extensions of the standard model generically predict that in the early Universe a scalar condensate can form and fragment into Q balls before decaying. If the Q balls dominate the energy density for some period of time, the relatively large fluctuations in their number density can lead to formation of primordial black holes (PBH). Other scalar fields, unrelated to supersymmetry, can play a similar role. For a general charged scalar field, this robust mechanism can generate black holes over the entire mass range allowed by observational constraints, with a sufficient abundance to account for all dark matter in some parameter ranges. In the case of supersymmetry the mass range is limited from above by 10^{23}  g. We also comment on the role that topological defects can play for PBH formation in a similar fashion.

  20. All-sky reconstruction of the primordial scalar potential & implications

    Science.gov (United States)

    Dorn, Sebastian; Greiner, Maksim; Ensslin, Torsten A.

    2015-08-01

    An essential quantity required to understand the physics of the early Universe is the primordial scalar potential and its statistics. We present an inexpensive all-sky reconstruction of the potential from CMB temperature data as well as an extension including polarization data. This has been achieved by applying a fully parallelized Bayesian inference method that separates the whole inverse problem into many, each of them solved by an optimal linear filter. Once explicitly having the potential, its statistics and underlying physics can be directly obtained avoiding expensive CMB analyses. This reconstruction, for instance, allows to infer the spatial structure of magnetic fields within the recombination epoch, the potential seeds of large-scale magnetic fields nowadays.

  1. Very Short Gamma Ray Bursts Study and Primordial Black Holes

    Energy Technology Data Exchange (ETDEWEB)

    Cline, David [UCLA Physics and Astronomy Department, Physics and Astronomy Building, 430 Portola Plaza, Los Angeles, CA 90095-1547 (United States)

    2010-07-01

    We show the locations of the SWIFT short hard bursts (SHB) with afterglows on the Galactic map and compare with the VSB BATSE events. As we have pointed out before, there is an excess of events in the galactic map of BATSE VSB events. We note, that none of VSB SWIFT era events fall into this cluster. More SWIFT events are needed to check this claim. We also report a new study with KONUS data of the VSB sample with an average energy above 90 keV showing a clear excess of events below 100 ms duration (T90) that have large mean energy photons. We suggest that VSB themselves consists of two subclasses: a reaction of events have peculiar distribution properties and have no detectable counter parts, as might be expected for exotic sources such as Primordial Black Holes. New results from SWIFT will be compared with the BATSE VSB data. (author)

  2. Bicycling to Work and Primordial Prevention of Cardiovascular Risk

    DEFF Research Database (Denmark)

    Grøntved, Anders; Koivula, Robert W; Johansson, Ingegerd

    2016-01-01

    BACKGROUND: Bicycling to work may be a viable approach for achieving physical activity that provides cardiovascular health benefits. In this study we investigated the relationship of bicycling to work with incidence of obesity, hypertension, hypertriglyceridemia, and impaired glucose tolerance...... across a decade of follow-up in middle-aged men and women. METHODS AND RESULTS: We followed 23 732 Swedish men and women with a mean age of 43.5 years at baseline who attended a health examination twice during a 10-year period (1990-2011). In multivariable adjusted models we calculated the odds......% CI 0.74-0.91) compared with participants not cycling to work at both times points or who switched from cycling to other modes of transport during follow-up. CONCLUSIONS: These data suggest that commuting by bicycle to work is an important strategy for primordial prevention of clinical cardiovascular...

  3. Solving puzzles of GW150914 by primordial black holes

    CERN Document Server

    Blinnikov, S; Porayko, N K; Postnov, K

    2016-01-01

    The black hole binary properties inferred from the LIGO gravitational wave signal GW150914 posed several serious problems. The high masses and low effective spin of black hole binary can be explained if they are primordial (PBH) rather than the products of the stellar binary evolution. Such PBH properties are postulated ad hoc but not derived from fundamental theory. We show that the necessary features of PBHs naturally follow from the slightly modified Affleck-Dine (AD) mechanism of baryogenesis. The log-normal distribution of PBHs, predicted within the AD paradigm, is adjusted to provide an abundant population of low-spin stellar mass black holes. The same distribution gives a sufficient number of quickly growing seeds of supermassive black holes observed at high redshifts and may comprise an appreciable fraction of Dark Matter which does not contradict any existing observational limits. Testable predictions of this scenario are discussed.

  4. Primordial perturbations from slow-roll inflation on a brane

    CERN Document Server

    Koyama, K; Mennim, A; Rubakov, V A; Wands, D; Hiramatsu, Takashi; Koyama, Kazuya; Mennim, Andrew; Wands, David

    2007-01-01

    In this paper we quantise scalar perturbations in a Randall-Sundrum-type model of inflation where the inflaton field is confined to a single brane embedded in five-dimensional anti-de Sitter space-time. In the high energy regime, small-scale inflaton fluctuations are strongly coupled to metric perturbations in the bulk and gravitational back-reaction has a dramatic effect on the behaviour of inflaton perturbations on sub-horizon scales. This is in contrast to the standard four-dimensional result where gravitational back-reaction can be neglected on small scales. Nevertheless, this does not give rise to significant particle production, and the correction to the power spectrum of the curvature perturbations on super-horizon scales is shown to be suppressed by a slow-roll parameter. We calculate the complete first order slow-roll corrections to the spectrum of primordial curvature perturbations.

  5. Prospects for Primordial Gravitational Waves in String Inflation

    CERN Document Server

    Parameswaran, Susha L

    2016-01-01

    Assuming that the early universe had (i) a description using perturbative string theory and its field theory limit (ii) an epoch of slow-roll inflation within a four-dimensional effective field theory and a hierarchy of scales $M_{inf} < M_{mod} < M_{kk} < m_s \\lesssim M_{pl}$ that keeps the latter under control, we derive an upper bound on the amplitude of primordial gravitational waves. The bound is very sensitive to mild changes in numerical coefficients and the expansion parameters. For example, allowing couplings and mass-squared hierarchies $\\lesssim 0.2$, implies $r \\lesssim 0.002$, but asking more safely for hierarchies $\\lesssim 0.1$, the bound becomes $r \\lesssim 10^{-8}$. Moreover, large volumes -- typically used in string models to keep backreaction and moduli stabilisation under control -- drive $r$ down. Consequently, any detection of inflationary gravitational waves would present an interesting but difficult challenge for string theory.

  6. Small-Scale Dynamo Action in Primordial Halos

    CERN Document Server

    Schober, Jennifer; Klessen, Ralf S; Federrath, Christoph; Bovino, Stefano; Glover, Simon; Banerjee, Robi

    2012-01-01

    The first galaxies form due to gravitational collapse of primordial halos. During this collapse, weak magnetic seed fields get amplified exponentially by the small-scale dynamo - a process converting kinetic energy from turbulence into magnetic energy. We use the Kazantsev theory, which describes the small-scale dynamo analytically, to study magnetic field amplification for different turbulent velocity correlation functions. For incompressible turbulence (Kolmogorov turbulence), we find that the growth rate is proportional to the square root of the hydrodynamic Reynolds number, Re^(1/2). In the case of highly compressible turbulence (Burgers turbulence) the growth rate increases proportional to Re^(1/3). With a detailed chemical network we are able to follow the chemical evolution and determine the kinetic and magnetic viscosities (due to Ohmic and ambipolar diffusion) during the collapse of the halo. This way, we can calculate the growth rate of the small-scale dynamo quantitatively and predict the evolution...

  7. Noncommutative geometry and the primordial dipolar imaginary power spectrum

    Energy Technology Data Exchange (ETDEWEB)

    Jain, Pankaj; Rath, Pranati K. [Indian Institue of Technology Kanpur, Department of Physics, Kanpur (India)

    2015-03-01

    We argue that noncommutative space-times lead to an anisotropic dipolar imaginary primordial power spectrum. We define a new product rule, which allows us to consistently extract the power spectrum in such space-times. The precise nature of the power spectrum depends on the model of noncommutative geometry. We assume a simple dipolar model which has a power dependence on the wave number, k, with a spectral index, α. We show that such a spectrum provides a good description of the observed dipole modulation in the cosmic microwave background radiation (CMBR) data with α ∼ 0. We extract the parameters of this model from the data. The dipole modulation is related to the observed hemispherical anisotropy in the CMBR data, which might represent the first signature of quantum gravity. (orig.)

  8. Noncommutative geometry and the primordial dipolar imaginary power spectrum

    Science.gov (United States)

    Jain, Pankaj; Rath, Pranati K.

    2015-03-01

    We argue that noncommutative space-times lead to an anisotropic dipolar imaginary primordial power spectrum. We define a new product rule, which allows us to consistently extract the power spectrum in such space-times. The precise nature of the power spectrum depends on the model of noncommutative geometry. We assume a simple dipolar model which has a power dependence on the wave number, , with a spectral index, . We show that such a spectrum provides a good description of the observed dipole modulation in the cosmic microwave background radiation (CMBR) data with . We extract the parameters of this model from the data. The dipole modulation is related to the observed hemispherical anisotropy in the CMBR data, which might represent the first signature of quantum gravity.

  9. Precision of future experiments measuring primordial tensor fluctuation

    CERN Document Server

    Wang, Yi

    2014-01-01

    Recently the second phase of Background Imaging of Cosmic Extragalactic Polarization (BICEP2) claimed a detection of the tensor-to-scalar ratio ($r$) of primordial fluctuation at $5\\sigma$ confidence level. If it is true, this large and measurable amplitude ($r \\simeq 0.2$) of B-mode polarization indicates that it is possible to measure the shape of CMB B-mode polarization with future experiments. Given the current understanding of the experimental noise and foreground contamination, we forecast the precision of $r$ and the tensor spectral index $n_{\\rm t}$ measurements from Planck, Spider and POLARBEAR with $n_{\\rm t}$ as a free parameter. We quantitatively determine the signal-to-noise of the measurement in $r$-$n_{\\rm t}$ parameter space for the three experiments. The forecasted signal-to-noise ratio of the B-mode polarization somewhat depends on $n_{\\rm t}$, but strongly depends on the true value of $r$.

  10. Quantum Origin of the Primordial Fluctuation Spectrum and its Statistics

    CERN Document Server

    Leon, Gabriel; Sudarsky, Daniel

    2013-01-01

    The account of the origin of cosmic structure, as provided by the standard inflationary paradigm, is not fully satisfactory, as has been argued in Perez et al 2006. The central point of that work is to point out the need to discuss and explore the physical mechanism that is capable of generating the inhomogeneity and anisotropy of our Universe, starting from an exactly homogeneous and isotropic initial state associated with the early inflationary regime. We review this issue briefly here together with the proposal to address this shortcoming in terms of a dynamical collapse of the vacuum state of the inflaton field. We also briefly indicate how this issues might be connected to other questions being faced in the study of the quantum/gravity interface, and their relevance to the investigations concerning the statistical characterization of the primordial spectrum.

  11. Effective conductance method for the primordial recombination spectrum

    CERN Document Server

    Ali-Haïmoud, Yacine

    2012-01-01

    As atoms formed for the first time during primordial recombination, they emitted bound-bound and free-bound radiation leading to spectral distortions to the cosmic microwave background. These distortions might become observable in the future with high-sensitivity spectrometers, and provide a new window into physical conditions in the early universe. The standard multilevel atom method habitually used to compute the recombination spectrum is computationally expensive, impeding a detailed quantitative exploration of the information contained in spectral distortions thus far. In this work it is shown that the emissivity in optically thin allowed transitions can be factored into a computationally expensive but cosmology-independent part and a computationally cheap, cosmology-dependent part. The slow part of the computation consists in pre-computing temperature-dependent effective "conductances", linearly relating line or continuum intensity to departures from Saha equilibrium of the lowest-order excited states (2...

  12. Generation of dynamo magnetic fields in the primordial solar nebula

    Science.gov (United States)

    Stepinski, Tomasz F.

    1992-01-01

    The present treatment of dynamo-generated magnetic fields in the primordial solar nebula proceeds in view of the ability of the combined action of Keplerian rotation and helical convention to generate, via alpha-omega dynamo, large-scale magnetic fields in those parts of the nebula with sufficiently high, gas-and magnetic field coupling electrical conductivity. Nebular gas electrical conductivity and the radial distribution of the local dynamo number are calculated for both a viscous-accretion disk model and the quiescent-minimum mass nebula. It is found that magnetic fields can be easily generated and maintained by alpha-omega dynamos occupying the inner and outer parts of the nebula.

  13. Volatile inventories in clathrate hydrates formed in the primordial nebula

    CERN Document Server

    Mousis, O; Picaud, S; Cordier, D

    2010-01-01

    Examination of ambient thermodynamic conditions suggest that clathrate hydrates could exist in the martian permafrost, on the surface and in the interior of Titan, as well as in other icy satellites. Clathrate hydrates probably formed in a significant fraction of planetesimals in the solar system. Thus, these crystalline solids may have been accreted in comets, in the forming giant planets and in their surrounding satellite systems. In this work, we use a statistical thermodynamic model to investigate the composition of clathrate hydrates that may have formed in the primordial nebula. In our approach, we consider the formation sequence of the different ices occurring during the cooling of the nebula, a reasonable idealization of the process by which volatiles are trapped in planetesimals. We then determine the fractional occupancies of guests in each clathrate hydrate formed at given temperature. The major ingredient of our model is the description of the guest-clathrate hydrate interaction by a spherically a...

  14. Primordial Universe Inside the Black Hole and Inflation

    CERN Document Server

    Firouzjahi, Hassan

    2016-01-01

    We speculate that the early Universe was inside a primordial black hole. The interior of the the black hole is a dS background and the two spacetimes are separated on the surface of black hole's event horizon. We argue that this picture provides a natural realization of inflation without invoking the inflaton field. The black hole evaporation by Hawking radiation provides a natural mechanism for terminating inflation so reheating and the hot big bang cosmology starts from the evaporation of black hole to relativistic particles. The quantum gravitational fluctuations at the boundary of black hole generate the nearly scale invariant scalar and tensor perturbations with the ratio of tensor to scalar power spectra at the order of $10^{-3}$. As the black hole evaporates, the radius of its event horizon shrinks and the Hubble expansion rate during inflation increases slowly so the quantum Hawking radiation provides a novel mechanism for the violation of null energy condition in cosmology.

  15. Probing polarization states of primordial gravitational waves with CMB anisotropies

    CERN Document Server

    Saito, Shun; Taruya, Atsushi

    2007-01-01

    We discuss the polarization signature of primordial gravitational waves imprinted in cosmic microwave background (CMB) anisotropies. The high-energy physics motivated by superstring theory or M-theory generically yield parity violating terms, which may produce a circularly polarized gravitational wave background (GWB) during inflation. In contrast to the standard prediction of inflation with un-polarized GWB, circularly polarized GWB generates non-vanishing TB and EB-mode power spectra of CMB anisotropies. We evaluate the TB and EB-mode power spectra taking into account the secondary effects and investigate the dependence of cosmological parameters. We then discuss current constraints on the circularly polarized GWB from large angular scales (l < 16) of the three year WMAP data. Prospects for future CMB experiments are also investigated based on a Monte Carlo analysis of parameter estimation, showing that the circular polarization degree, varepsilon, which is the asymmetry of the tensor power spectra betwe...

  16. The origin of large molecules in primordial autocatalytic reaction networks

    CERN Document Server

    Giri, Varun

    2011-01-01

    Large molecules such as proteins and nucleic acids are crucial for life, yet their primordial origin remains a major puzzle. The production of large molecules, as we know it today, requires good catalysts, and the only good catalysts we know that can accomplish this task consist of large molecules. Thus the origin of large molecules is a chicken and egg problem in chemistry. Here we present a mechanism, based on autocatalytic sets (ACSs), that is a possible solution to this problem. We discuss a mathematical model describing the population dynamics of molecules in a stylized but prebiotically plausible chemistry. Large molecules can be produced in this chemistry by the coalescing of smaller ones, with the smallest molecules, the `food set', being buffered. Some of the reactions can be catalyzed by molecules within the chemistry with varying catalytic strengths. Normally the concentrations of large molecules in such a scenario are very small, diminishing exponentially with their size. ACSs, if present in the c...

  17. The Nature of Primordial Fluctuations from Anisotropic Inflation

    CERN Document Server

    Watanabe, Masa-aki; Soda, Jiro

    2010-01-01

    We study the statistical nature of primordial fluctuations from an anisotropic inflation which is realized by a vector field coupled to an inflaton. We find a suitable gauge, which we call the canonical gauge, for anisotropic inflation by generalizing the flat slicing gauge in conventional isotropic inflation. Using the canonical gauge, we reveal the structure of the couplings between curvature perturbations, vector waves, and gravitational waves. We identify two sources of anisotropy, i.e. the anisotropy due to the anisotropic expansion of the universe and that due to the anisotropic couplings among variables. It turns out that the latter effect is dominant. Since the coupling between the curvature perturbations and vector waves is the strongest one, the statistical anisotropy in the curvature perturbations is larger than that in gravitational waves. We find the cross correlation between the curvature perturbations and gravitational waves which never occurs in conventional inflation. We also find the linear ...

  18. FGF, Insulin, and SMAD Signaling Cooperate for Avian Primordial Germ Cell Self-Renewal

    Directory of Open Access Journals (Sweden)

    Jemima Whyte

    2015-12-01

    Full Text Available Precise self-renewal of the germ cell lineage is fundamental to fertility and reproductive success. The early precursors for the germ lineage, primordial germ cells (PGCs, survive and proliferate in several embryonic locations during their migration to the embryonic gonad. By elucidating the active signaling pathways in migratory PGCs in vivo, we were able to create culture conditions that recapitulate this embryonic germ cell environment. In defined medium conditions without feeder cells, the growth factors FGF2, insulin, and Activin A, signaling through their cognate-signaling pathways, were sufficient for self-renewal of germline-competent PGCs. Forced expression of constitutively active MEK1, AKT, and SMAD3 proteins could replace their respective upstream growth factors. Unexpectedly, we found that BMP4 could replace Activin A in non-clonal growth conditions. These defined medium conditions identify the key molecular pathways required for PGC self-renewal and will facilitate efforts in biobanking of chicken genetic resources and genome editing.

  19. Testing the Creation of the Universe: The Primordial Helium Abundance

    Directory of Open Access Journals (Sweden)

    R. P. Bauman

    2003-01-01

    Full Text Available Las mediciones de alta precisión de la abundancia primordial de elementos ligeros es una de las pruebas fundamentales del Big Bang. La abundancia primordial de helio, Yp, el cociente de He a H por masa, se determina por las líneas de emisión que se forman durante el proceso de recombinación-decaimiento, He++e- → Heº (nL+hv, seguido de la cascada radiativa. Una prueba definitiva del Big Bang requiere una precisión del 1% o mejor. Yp se mide de los cocientes de intensidades de líneas de recombinación de He I y H I en regiones H II. El cociente de densidad n(He+/n(H+ es proporcional a la intensidad de las líneas observadas y al cociente inverso de los coeficientes de recombinación. Los estudios previos de coeficientes de recombinación de He I suponen que los tripletes y singuletes son diferentes sistemas de cascadas radiativas que se comunican únicamente por colisiones con intercambio de electrones. De hecho, algunos niveles de alto momento angular tienen multiplicidades de espin mixto, lo que lleva a decaiminetos convencionales de dipolo eléctrico que mezclan a los tripletes y singuletes. Presentamos cálculos tentativos de los coeficientes de recombinación de He I a una temperatura de 10,000 K en el “caso B". Se anticipan diferencias de 1% o mayor que pueden afectar la Yp en cantidades cosmológicamente significativas.

  20. Cosmological long-wavelength solutions and primordial black hole formation

    Science.gov (United States)

    Harada, Tomohiro; Yoo, Chul-Moon; Nakama, Tomohiro; Koga, Yasutaka

    2015-04-01

    We construct cosmological long-wavelength solutions without symmetry in general gauge conditions which are compatible with the long-wavelength scheme. We then specify the relationship among the solutions in different time slicings. Nonspherical long-wavelength solutions are particularly important for primordial structure formation in the epoch of very soft equations of state. Applying this general framework to spherical symmetry, we show the equivalence between long-wavelength solutions in the constant mean curvature slicing with conformally flat spatial coordinates and asymptotic quasihomogeneous solutions in the comoving slicing with the comoving threading. We derive the correspondence relation between these two solutions and compare the results of numerical simulations of primordial black hole (PBH) formation in these two different approaches. To discuss the PBH formation, it is convenient and conventional to use δ˜c, the value which the averaged density perturbation at threshold in the comoving slicing would take at horizon entry in the lowest-order long-wavelength expansion. We numerically find that within (approximately) compensated models, the sharper the transition from the overdense region to the Friedmann-Robertson-Walker universe is, the larger the δ˜ c becomes. We suggest that, for the equation of state p =(Γ -1 )ρ , we can apply the analytic formulas for the minimum δ˜ c ,min≃[3 Γ /(3 Γ +2 )]sin2[π √{Γ -1 }/(3 Γ -2 )] and the maximum δ˜ c ,max≃3 Γ /(3 Γ +2 ) . As for the threshold peak value of the curvature variable ψ0 ,c , we find that the sharper the transition is, the smaller the ψ0 ,c becomes. We analytically explain this intriguing feature qualitatively with a compensated top-hat density model. Using simplified models, we also analytically deduce an environmental effect that ψ0 ,c can be significantly larger (smaller) if the underlying perturbation of much longer wavelength is positive (negative).

  1. The evolution of primordial magnetic fields since their generation

    Science.gov (United States)

    Kahniashvili, Tina; Brandenburg, Axel; Tevzadze, Alexander G.

    2016-10-01

    We study the evolution of primordial magnetic fields in an expanding cosmic plasma. For this purpose we present a comprehensive theoretical model to consider the evolution of MHD turbulence that can be used over a wide range of physical conditions, including cosmological and astrophysical applications. We model different types of decaying cosmic MHD turbulence in the expanding Universe and characterize the large-scale magnetic fields in such a medium. Direct numerical simulations of freely decaying MHD turbulence are performed for different magnetogenesis scenarios: magnetic fields generated during cosmic inflation as well as electroweak and QCD phase transitions in the early Universe. Magnetic fields and fluid motions are strongly coupled due to the high Reynolds number in the early Universe. Hence, we abandon the simple adiabatic dilution model to estimate magnetic field amplitudes in the expanding Universe and include turbulent mixing effects on the large-scale magnetic field evolution. Numerical simulations have been carried out for non-helical and helical magnetic field configurations. The numerical results show the possibility of inverse transfer of energy in magnetically dominated non-helical MHD turbulence. On the other hand, decay properties of helical turbulence depend on whether the turbulent magnetic field is in a weakly or a fully helical state. Our results show that primordial magnetic fields can be considered as a seed for the observed large-scale magnetic fields in galaxies and clusters. Bounds on the magnetic field strength are obtained and are consistent with the upper and lower limits set by observations of extragalactic magnetic fields.

  2. Molecular diagnosis of putative Stargardt disease probands by exome sequencing

    Directory of Open Access Journals (Sweden)

    Strom Samuel P

    2012-08-01

    Full Text Available Abstract Background The commonest genetic form of juvenile or early adult onset macular degeneration is Stargardt Disease (STGD caused by recessive mutations in the gene ABCA4. However, high phenotypic and allelic heterogeneity and a small but non-trivial amount of locus heterogeneity currently impede conclusive molecular diagnosis in a significant proportion of cases. Methods We performed whole exome sequencing (WES of nine putative Stargardt Disease probands and searched for potentially disease-causing genetic variants in previously identified retinal or macular dystrophy genes. Follow-up dideoxy sequencing was performed for confirmation and to screen for mutations in an additional set of affected individuals lacking a definitive molecular diagnosis. Results Whole exome sequencing revealed seven likely disease-causing variants across four genes, providing a confident genetic diagnosis in six previously uncharacterized participants. We identified four previously missed mutations in ABCA4 across three individuals. Likely disease-causing mutations in RDS/PRPH2, ELOVL, and CRB1 were also identified. Conclusions Our findings highlight the enormous potential of whole exome sequencing in Stargardt Disease molecular diagnosis and research. WES adequately assayed all coding sequences and canonical splice sites of ABCA4 in this study. Additionally, WES enables the identification of disease-related alleles in other genes. This work highlights the importance of collecting parental genetic material for WES testing as the current knowledge of human genome variation limits the determination of causality between identified variants and disease. While larger sample sizes are required to establish the precision and accuracy of this type of testing, this study supports WES for inherited early onset macular degeneration disorders as an alternative to standard mutation screening techniques.

  3. Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.

    Science.gov (United States)

    Kim, Bongki; Kim, Youngha; Sakuma, Rui; Hui, Chi-Chung; Rüther, Ulrich; Jorgensen, Joan S

    2011-01-15

    Over the first 4 days of their life, primordial germ cells invade the endoderm, migrate into and through the developing hindgut, and traverse to the genital ridge where they cluster and ultimately inhabit the nascent gonad. Specific signal-receptor combinations between primordial germ cells and their immediate environment establish successful migration and colonization. Here we demonstrate that disruption of a cluster of six genes on murine chromosome 8, as exemplified by the Fused Toes (Ft) mutant mouse model, results in severely decreased numbers of primordial germ cells within the early gonad. Primordial germ cell migration appeared normal within Ft mutant embryos; however, germ cell counts progressively decreased during this time. Although no difference in apoptosis was detected, we report a critical decrease in primordial germ cell proliferation by E12.5. The six genes within the Ft locus include the IrxB cluster (Irx3, -5, -6), Fts, Ftm, and Fto, of which only Ftm, Fto, and Fts are expressed in primordial germ cells of the early gonad. From these studies, we have discovered that the Ft locus on mouse chromosome 8 is associated with cell cycle deficits within the primordial germ cell population that initiates just before translocation into the genital ridge. Copyright © 2010 Elsevier Inc. All rights reserved.

  4. Comparative proteomic analysis of primordial follicles from ovaries of immature and aged rats.

    Science.gov (United States)

    Govindaraj, Vijayakumar; Rao, A Jagannadha

    2015-01-01

    Age related decline in reproductive performance in women is well documented and apoptosis has been considered as one of the reasons for the decline of primordial follicle reserve. Recently we observed a decline in the efficiency of DNA repair ability in aged rat primordial follicles as demonstrated by decreased mRNA levels of DNA repair genes BRCA1 and H2AX. In the present study, a two-dimensional electrophoresis (2DE) proteomic approach was employed to identify differentially expressed proteins in primordial follicles isolated from ovaries of immature (∼20 days) and aged (∼400-450 days) rats. Using MALDI-TOF/TOF MS, we identified 13 differentially expressed proteins (p primordial follicles. These proteins are involved in a wide range of biological functions including apoptosis, DNA repair, and the immune system. Interestingly, the differentially expressed proteins such as FIGNL1 (DNA repair) and BOK (apoptotic protein) have not been previously reported in the rat primordial follicles and these proteins can be related to some common features of ovarian aging such as loss of follicle reserve and genome integrity. The quantitative differences of two important proteins BOK and FIGNL1 observed by the proteomic analysis were correlated with the transcript levels, as determined by semi-quantitative RT-PCR. Our results improve the current knowledge about protein factors associated with molecular changes in rat primordial follicles as a function of aging and our understanding of the proteomic processes involved in degenerative changes observed in aging primordial follicles.

  5. Isolated primate primordial follicles require a rigid physical environment to survive and grow in vitro.

    Science.gov (United States)

    Hornick, J E; Duncan, F E; Shea, L D; Woodruff, T K

    2012-06-01

    In vitro follicle growth is a promising fertility preservation strategy in which ovarian follicles are cultured to produce mature and fertilization-competent oocytes. However, in primates, there has been limited success with in vitro follicle growth starting from primordial and primary follicles because adequate isolation methods and culture strategies have not been established. Understanding how to use primordial follicles for fertility preservation has significant implications because these follicles are the most abundant in the ovary, are found in all females and are fairly resistant to cryopreservation and chemotherapeutics. In the primate ovary, primordial follicles are concentrated near the collagen-rich ovarian cortex. To obtain these follicles, we separated the ovarian cortex prior to enzymatic digestion and enriched the primordial follicle concentration by using a novel double filtration system. To test the hypothesis that a rigid physical environment, as found in vivo, is optimal for survival, primordial follicles were cultured in different concentrations of alginate for up to 6 days. Follicle survival and morphology were monitored throughout the culture. We found that primate ovarian tissue can be maintained for up to 24 h at 4°C without compromising tissue or follicle health. Hundreds of intact and viable primordial follicles were isolated from each ovary independent of animal age. Follicle survival and morphology were more optimal when follicles were cultured in 2% alginate compared with 0.5% alginate. By mimicking the rigid ovarian environment through the use of biomaterials, we have established conditions that support primordial follicle culture. These results lay the foundations for studying the basic biology of primordial follicles in a controlled environment and for using primordial follicles for fertility preservation methods.

  6. Genetic susceptibility of periodontitis

    NARCIS (Netherlands)

    Laine, M.L.; Crielaard, W.; Loos, B.G.

    2012-01-01

    In this systematic review, we explore and summarize the peer-reviewed literature on putative genetic risk factors for susceptibility to aggressive and chronic periodontitis. A comprehensive literature search on the PubMed database was performed using the keywords ‘periodontitis’ or ‘periodontal dise

  7. New evidence for the origin of intracranial germ cell tumours from primordial germ cells

    DEFF Research Database (Denmark)

    Hoei-Hansen, C E; Sehested, A; Juhler, M

    2006-01-01

    Primary intracranial germ cell tumours are rare neoplasms that occur in children and adolescents. This study examined both the biology and the origin of these tumours, as it has been hypothesized that they originate from a totipotent primordial germ cell. We applied recent knowledge from gonadal...... with their gonadal equivalents, including a close similarity with primordial germ cells. A notable difference was the sex-specific expression of TSPY, a gene previously implicated in the origin of gonadoblastoma. TSPY was only detected in germ cell tumours in the central nervous system (CNS) from males, suggesting...... is a hallmark of primordial germ cells....

  8. Primordial gravitational waves induced by magnetic fields in an ekpyrotic scenario

    Science.gov (United States)

    Ito, Asuka; Soda, Jiro

    2017-08-01

    Both inflationary and ekpyrotic scenarios can account for the origin of the large scale structure of the universe. It is often said that detecting primordial gravitational waves is the key to distinguish both scenarios. We show that this is not true if the gauge kinetic function is present in the ekpyrotic scenario. In fact, primordial gravitational waves sourced by the gauge field can be produced in an ekpyrotic universe. We also study scalar fluctuations sourced by the gauge field and show that it is negligible compared to primordial gravitational waves. This comes from the fact that the fast roll condition holds in ekpyrotic models.

  9. Gravitational Wave Signatures of Dark Matter Sub-Millimeter Primordial Black Holes

    CERN Document Server

    Davoudiasl, Hooman

    2016-01-01

    We entertain the possibility that primordial black holes of mass $\\sim (10^{24} - 10^{26})$ g, with sub-millimeter Schwarzschild radii, constitute all or a significant fraction of cosmic dark matter, as allowed by various constraints. In case such primordial black holes get captured in orbits around neutron stars or astrophysical black holes in our galactic neighborhood, gravitational waves from the resulting "David & Goliath" binaries could be detectable at Advanced LIGO or Advanced Virgo from days to years, for a range of possible parameters. The proposed Einstein Telescope would further expand the reach for dark matter primordial black holes in this search mode.

  10. Primordial blackholes and gravitational waves for an inflection-point model of inflation

    Energy Technology Data Exchange (ETDEWEB)

    Choudhury, Sayantan [Physics and Applied Mathematics Unit, Indian Statistical Institute, 203 B.T. Road, Kolkata 700 108 (India); Mazumdar, Anupam [Consortium for Fundamental Physics, Physics Department, Lancaster University, LA1 4YB (United Kingdom)

    2014-06-02

    In this article we provide a new closed relationship between cosmic abundance of primordial gravitational waves and primordial blackholes that originated from initial inflationary perturbations for inflection-point models of inflation where inflation occurs below the Planck scale. The current Planck constraint on tensor-to-scalar ratio, running of the spectral tilt, and from the abundance of dark matter content in the universe, we can deduce a strict bound on the current abundance of primordial blackholes to be within a range, 9.99712×10{sup −3}<Ω{sub PBH}h{sup 2}<9.99736×10{sup −3}.

  11. Primordial blackholes and gravitational waves for an inflection-point model of inflation

    Science.gov (United States)

    Choudhury, Sayantan; Mazumdar, Anupam

    2014-06-01

    In this article we provide a new closed relationship between cosmic abundance of primordial gravitational waves and primordial blackholes that originated from initial inflationary perturbations for inflection-point models of inflation where inflation occurs below the Planck scale. The current Planck constraint on tensor-to-scalar ratio, running of the spectral tilt, and from the abundance of dark matter content in the universe, we can deduce a strict bound on the current abundance of primordial blackholes to be within a range, 9.99712 ×10-3 <ΩPBHh2 < 9.99736 ×10-3.

  12. Review of Big Bang Nucleosynthesis and Primordial Abundances

    Science.gov (United States)

    Tytler, David; O'Meara, John M.; Suzuki, Nao; Lubin, Dan

    2001-03-01

    Big Bang Nucleosynthesis (BBN) is the synthesis of the light nuclei, Deuterium (D or 2H), 3He, 4He and 7Li during the first few minutes of the universe. This review concentrates on recent improvements in the measurement of the primordial (after BBN, and prior to modification) abundances of these nuclei. We mention improvement in the standard theory, and the non-standard extensions which are limited by the data. We have achieved an order of magnitude improvement in the precision of the measurement of primordial D/H, using the HIRES spectrograph on the W. M. Keck telescope to measure D in gas with very nearly primordial abundances towards quasars. From 1994 - 1996, it appeared that there could be a factor of ten range in primordial D/H, but today four examples of low D are secure. High D/H should be much easier to detect, and since there are no convincing examples, it must be extremely rare or non-existent. All data are consistent with a single low value for D/H, and the examples which are consistent with high D/H are readily interpreted as H contamination near the position of D. The new D/H measurements give the most accurate value for the baryon to photon ratio, η, and hence the cosmological baryon density. A similar density is required to explain the amount of Lyα absorption from neutral Hydrogen in the intergalactic medium (IGM) at redshift z ≃ 3, and to explain the fraction of baryons in local clusters of galaxies. The D/H measurements lead to predictions for the abundances of the other light nuclei, which generally agree with measurements. The remaining differences with some measurements can be explained by a combination of measurement and analysis errors or changes in the abundances after BBN. The measurements do not require physics beyond the standard BBN model. Instead, the agreement between the abundances is used to limit the non-standard physics. New measurements are giving improved understanding of the difficulties in estimating the abundances of all

  13. Cryptic species in putative ancient asexual darwinulids (Crustacea, Ostracoda.

    Directory of Open Access Journals (Sweden)

    Isa Schön

    Full Text Available BACKGROUND: Fully asexually reproducing taxa lack outcrossing. Hence, the classic Biological Species Concept cannot be applied. METHODOLOGY/PRINCIPAL FINDINGS: We used DNA sequences from the mitochondrial COI gene and the nuclear ITS2 region to check species boundaries according to the evolutionary genetic (EG species concept in five morphospecies in the putative ancient asexual ostracod genera, Penthesilenula and Darwinula, from different continents. We applied two methods for detecting cryptic species, namely the K/θ method and the General Mixed Yule Coalescent model (GMYC. We could confirm the existence of species in all five darwinulid morphospecies and additional cryptic diversity in three morphospecies, namely in Penthesilenula brasiliensis, Darwinula stevensoni and in P. aotearoa. The number of cryptic species within one morphospecies varied between seven (P. brasiliensis, five to six (D. stevensoni and two (P. aotearoa, respectively, depending on the method used. Cryptic species mainly followed continental distributions. We also found evidence for coexistence at the local scale for Brazilian cryptic species of P. brasiliensis and P. aotearoa. Our ITS2 data confirmed that species exist in darwinulids but detected far less EG species, namely two to three cryptic species in P. brasiliensis and no cryptic species at all in the other darwinulid morphospecies. CONCLUSIONS/SIGNIFICANCE: Our results clearly demonstrate that both species and cryptic diversity can be recognized in putative ancient asexual ostracods using the EG species concept, and that COI data are more suitable than ITS2 for this purpose. The discovery of up to eight cryptic species within a single morphospecies will significantly increase estimates of biodiversity in this asexual ostracod group. Which factors, other than long-term geographic isolation, are important for speciation processes in these ancient asexuals remains to be investigated.

  14. Putative regulatory factors associated with intramuscular fat content.

    Directory of Open Access Journals (Sweden)

    Aline S M Cesar

    Full Text Available Intramuscular fat (IMF content is related to insulin resistance, which is an important prediction factor for disorders, such as cardiovascular disease, obesity and type 2 diabetes in human. At the same time, it is an economically important trait, which influences the sensorial and nutritional value of meat. The deposition of IMF is influenced by many factors such as sex, age, nutrition, and genetics. In this study Nellore steers (Bos taurus indicus subspecies were used to better understand the molecular mechanisms involved in IMF content. This was accomplished by identifying differentially expressed genes (DEG, biological pathways and putative regulatory factors. Animals included in this study had extreme genomic estimated breeding value (GEBV for IMF. RNA-seq analysis, gene set enrichment analysis (GSEA and co-expression network methods, such as partial correlation coefficient with information theory (PCIT, regulatory impact factor (RIF and phenotypic impact factor (PIF were utilized to better understand intramuscular adipogenesis. A total of 16,101 genes were analyzed in both groups (high (H and low (L GEBV and 77 DEG (FDR 10% were identified between the two groups. Pathway Studio software identified 13 significantly over-represented pathways, functional classes and small molecule signaling pathways within the DEG list. PCIT analyses identified genes with a difference in the number of gene-gene correlations between H and L group and detected putative regulatory factors involved in IMF content. Candidate genes identified by PCIT include: ANKRD26, HOXC5 and PPAPDC2. RIF and PIF analyses identified several candidate genes: GLI2 and IGF2 (RIF1, MPC1 and UBL5 (RIF2 and a host of small RNAs, including miR-1281 (PIF. These findings contribute to a better understanding of the molecular mechanisms that underlie fat content and energy balance in muscle and provide important information for the production of healthier beef for human consumption.

  15. Ten Putative Contributors to the Obesity Epidemic

    Science.gov (United States)

    McAllister, Emily J.; Dhurandhar, Nikhil V.; Keith, Scott W.; Aronne, Louis J.; Barger, Jamie; Baskin, Monica; Benca, Ruth M.; Biggio, Joseph; Boggiano, Mary M.; Eisenmann, Joe C.; Elobeid, Mai; Fontaine, Kevin R.; Gluckman, Peter; Hanlon, Erin C.; Katzmarzyk, Peter; Pietrobelli, Angelo; Redden, David T.; Ruden, Douglas M.; Wang, Chenxi; Waterland, Robert A.; Wright, Suzanne M.; Allison, David B.

    2010-01-01

    The obesity epidemic is a global issue and shows no signs of abating, while the cause of this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally-driven declines in physical activity are the alleged perpetrators for the epidemic, despite a lack of solid evidence to demonstrate their causal role. While both may contribute to obesity, we call attention to their unquestioned dominance in program funding and public efforts to reduce obesity, and propose several alternative putative contributors that would benefit from equal consideration and attention. Evidence for microorganisms, epigenetics, increasing maternal age, greater fecundity among people with higher adiposity, assortative mating, sleep debt, endocrine disruptors, pharmaceutical iatrogenesis, reduction in variability of ambient temperatures, and intrauterine and intergenerational effects, as contributing factors to the obesity epidemic are reviewed herein. While the evidence is strong for some contributors such as pharmaceutical-induced weight gain, it is still emerging for other reviewed factors. Considering the role of such putative etiological factors of obesity may lead to comprehensive, cause specific, and effective strategies for prevention and treatment of this global epidemic. PMID:19960394

  16. Follistatin288 Regulates Germ Cell Cyst Breakdown and Primordial Follicle Assembly in the Mouse Ovary.

    Science.gov (United States)

    Wang, Zhengpin; Niu, Wanbao; Wang, Yijing; Teng, Zhen; Wen, Jia; Xia, Guoliang; Wang, Chao

    2015-01-01

    In mammals, the primordial follicle pool represents the entire reproductive potential of a female. The transforming growth factor-β (TGF-β) family member activin (ACT) contributes to folliculogenesis, although the exact mechanism is not known. The role of FST288, the strongest ACT-neutralizing isoform of follistatin (FST), during cyst breakdown and primordial follicle formation in the fetal mice ovary was assessed using an in vitro culture system. FST was continuously expressed in the oocytes as well as the cuboidal granulosa cells of growing follicles in perinatal mouse ovaries. Treatment with FST288 delayed germ cell nest breakdown, particularly near the periphery of the ovary, and dramatically decreased the percentage of primordial follicles. In addition, there was a dramatic decrease in proliferation of granulosa cells and somatic cell expression of Notch signaling was impaired. In conclusion, FST288 impacts germ cell nest breakdown and primordial follicle assembly by inhibiting somatic cell proliferation.

  17. Ultrastructure of Sheep Primordial Follicles Cultured in the Presence of Indol Acetic Acid, EGF, and FSH

    Directory of Open Access Journals (Sweden)

    Evelyn Rabelo Andrade

    2011-01-01

    Full Text Available The aim of this study was to investigate the ultrastructural characteristics of primordial follicles after culturing of sheep ovarian cortical slices in the presence of indol acetic acid (IAA, Epidermal Growth Factor (EGF, and FSH. To evaluate ultrastructure of primordial follicles cultured in MEM (control or in MEM containing IAA, EGF, and FSH, fragments of cultured tissue were processes for transmission electron microscopy. Except in the control, primordial follicles cultured in supplemented media for 6 d were ultrastructurally normal. They had oocyte with intact nucleus and the cytoplasm contained heterogeneous-sized lipid droplets and numerous round or elongated mitochondria with intact parallel cristae were observed. Rough endoplasmic reticulum (RER was rarely found. The granulosa cells cytoplasm contained a great number of mitochondria and abundant RER. In conclusion, the presence of IAA, EGF, and FSH helped to maintain ultrastructural integrity of sheep primordial follicles cultured in vitro.

  18. Follistatin288 Regulates Germ Cell Cyst Breakdown and Primordial Follicle Assembly in the Mouse Ovary.

    Directory of Open Access Journals (Sweden)

    Zhengpin Wang

    Full Text Available In mammals, the primordial follicle pool represents the entire reproductive potential of a female. The transforming growth factor-β (TGF-β family member activin (ACT contributes to folliculogenesis, although the exact mechanism is not known. The role of FST288, the strongest ACT-neutralizing isoform of follistatin (FST, during cyst breakdown and primordial follicle formation in the fetal mice ovary was assessed using an in vitro culture system. FST was continuously expressed in the oocytes as well as the cuboidal granulosa cells of growing follicles in perinatal mouse ovaries. Treatment with FST288 delayed germ cell nest breakdown, particularly near the periphery of the ovary, and dramatically decreased the percentage of primordial follicles. In addition, there was a dramatic decrease in proliferation of granulosa cells and somatic cell expression of Notch signaling was impaired. In conclusion, FST288 impacts germ cell nest breakdown and primordial follicle assembly by inhibiting somatic cell proliferation.

  19. Expanding the phenotypic and mutational spectrum in microcephalic osteodysplastic primordial dwarfism type I.

    Science.gov (United States)

    Abdel-Salam, Ghada M H; Abdel-Hamid, Mohamed S; Issa, Mahmoud; Magdy, Ahmed; El-Kotoury, Ahmed; Amr, Khalda

    2012-06-01

    Mutations in the RNU4ATAC gene cause microcephalic osteodysplastic primordial dwarfism type I. It encodes U4atac, a small nuclear RNA that is a component of the minor spliceosome. Six distinct mutations in 30 patients diagnosed as microcephalic osteodysplastic primordial dwarfism type I have been described. We report on three additional patients from two unrelated families presenting with a milder phenotype of microcephalic osteodysplastic primordial dwarfism type I and metopic synostosis. Patient 1 had two novel heterozygous mutations in the 3' prime stem-loop, g.66G > C and g.124G > A while Patients 2 and 3 had a homozygous mutation g.55G > A in the 5' prime stem-loop. Although they manifested the known spectrum of clinical features of microcephalic osteodysplastic primordial dwarfism type I, they lacked evidence of severe developmental delay and neurological symptoms. These findings expand the mutational and phenotypic spectrum of this syndrome. Copyright © 2012 Wiley Periodicals, Inc.

  20. Novel Approach to the Dark Matter Problem: Primordial Intermediate-Mass Black Holes

    CERN Document Server

    Frampton, Paul H

    2016-01-01

    A discussion at a Scientific American level of the idea that the constituents of the dark mater in galactic halos are primordial intermediate-mass black holes with masses between ten and one hundred thousand times the solar mass.

  1. An MCMC determination of the primordial helium abundance

    Energy Technology Data Exchange (ETDEWEB)

    Aver, Erik; Olive, Keith A.; Skillman, Evan D., E-mail: aver@physics.umn.edu, E-mail: olive@umn.edu, E-mail: skillman@astro.umn.edu [School of Physics and Astronomy, University of Minnesota, 116 Church St. SE, Minneapolis, MN 55455 (United States)

    2012-04-01

    Spectroscopic observations of the chemical abundances in metal-poor H II regions provide an independent method for estimating the primordial helium abundance. H II regions are described by several physical parameters such as electron density, electron temperature, and reddening, in addition to y, the ratio of helium to hydrogen. It had been customary to estimate or determine self-consistently these parameters to calculate y. Frequentist analyses of the parameter space have been shown to be successful in these parameter determinations, and Markov Chain Monte Carlo (MCMC) techniques have proven to be very efficient in sampling this parameter space. Nevertheless, accurate determination of the primordial helium abundance from observations of H II regions is constrained by both systematic and statistical uncertainties. In an attempt to better reduce the latter, and continue to better characterize the former, we apply MCMC methods to the large dataset recently compiled by Izotov, Thuan, and Stasińska (2007). To improve the reliability of the determination, a high quality dataset is needed. In pursuit of this, a variety of cuts are explored. The efficacy of the He I λ4026 emission line as a constraint on the solutions is first examined, revealing the introduction of systematic bias through its absence. As a clear measure of the quality of the physical solution, a χ{sup 2} analysis proves instrumental in the selection of data compatible with the theoretical model. Nearly two-thirds of the observations fall outside a standard 95% confidence level cut, which highlights the care necessary in selecting systems and warrants further investigation into potential deficiencies of the model or data. In addition, the method also allows us to exclude systems for which parameter estimations are statistical outliers. As a result, the final selected dataset gains in reliability and exhibits improved consistency. Regression to zero metallicity yields Y{sub p} = 0.2534 ± 0.0083, in

  2. Precision Measures of the Primordial Abundance of Deuterium

    Science.gov (United States)

    Cooke, Ryan J.; Pettini, Max; Jorgenson, Regina A.; Murphy, Michael T.; Steidel, Charles C.

    2014-01-01

    We report the discovery of deuterium absorption in the very metal-poor ([Fe/H] = -2.88) damped Lyα system at z abs = 3.06726 toward the QSO SDSS J1358+6522. On the basis of 13 resolved D I absorption lines and the damping wings of the H I Lyα transition, we have obtained a new, precise measure of the primordial abundance of deuterium. Furthermore, to bolster the present statistics of precision D/H measures, we have reanalyzed all of the known deuterium absorption-line systems that satisfy a set of strict criteria. We have adopted a blind analysis strategy (to remove human bias) and developed a software package that is specifically designed for precision D/H abundance measurements. For this reanalyzed sample of systems, we obtain a weighted mean of (D/H)p = (2.53 ± 0.04) × 10-5, corresponding to a universal baryon density 100 Ωb, 0 h 2 = 2.202 ± 0.046 for the standard model of big bang nucleosynthesis (BBN). By combining our measure of (D/H)p with observations of the cosmic microwave background (CMB), we derive the effective number of light fermion species, N eff = 3.28 ± 0.28. We therefore rule out the existence of an additional (sterile) neutrino (i.e., N eff = 4.046) at 99.3% confidence (2.7σ), provided that the values of N eff and of the baryon-to-photon ratio (η10) did not change between BBN and recombination. We also place a strong bound on the neutrino degeneracy parameter, independent of the 4He primordial mass fraction, Y P: ξD = +0.05 ± 0.13 based only on the CMB+(D/H)p observations. Combining this value of ξD with the current best literature measure of Y P, we find a 2σ upper bound on the neutrino degeneracy parameter, |ξ| financial support of the W. M. Keck Foundation. Keck telescope time was partially granted by NOAO, through the Telescope System Instrumentation Program (TSIP). TSIP is funded by NSF.

  3. An MCMC determination of the primordial helium abundance

    Science.gov (United States)

    Aver, Erik; Olive, Keith A.; Skillman, Evan D.

    2012-04-01

    Spectroscopic observations of the chemical abundances in metal-poor H II regions provide an independent method for estimating the primordial helium abundance. H II regions are described by several physical parameters such as electron density, electron temperature, and reddening, in addition to y, the ratio of helium to hydrogen. It had been customary to estimate or determine self-consistently these parameters to calculate y. Frequentist analyses of the parameter space have been shown to be successful in these parameter determinations, and Markov Chain Monte Carlo (MCMC) techniques have proven to be very efficient in sampling this parameter space. Nevertheless, accurate determination of the primordial helium abundance from observations of H II regions is constrained by both systematic and statistical uncertainties. In an attempt to better reduce the latter, and continue to better characterize the former, we apply MCMC methods to the large dataset recently compiled by Izotov, Thuan, & Stasińska (2007). To improve the reliability of the determination, a high quality dataset is needed. In pursuit of this, a variety of cuts are explored. The efficacy of the He I λ4026 emission line as a constraint on the solutions is first examined, revealing the introduction of systematic bias through its absence. As a clear measure of the quality of the physical solution, a χ2 analysis proves instrumental in the selection of data compatible with the theoretical model. Nearly two-thirds of the observations fall outside a standard 95% confidence level cut, which highlights the care necessary in selecting systems and warrants further investigation into potential deficiencies of the model or data. In addition, the method also allows us to exclude systems for which parameter estimations are statistical outliers. As a result, the final selected dataset gains in reliability and exhibits improved consistency. Regression to zero metallicity yields Yp = 0.2534 ± 0.0083, in broad agreement

  4. Changes in ovarian protein expression during primordial follicle formation in the hamster.

    Science.gov (United States)

    Mukherjee, Anindit; Reisdorph, Nichole; Guda, Chttibabu; Pandey, Sanjit; Roy, Shyamal K

    2012-01-02

    Although many proteins have been shown to affect the transition of primordial follicles to the primary stage, factors regulating the formation of primordial follicles remains sketchy at best. Differentiation of somatic cells into early granulosa cells during ovarian morphogenesis is the hallmark of primordial follicle formation; hence, critical changes are expected in protein expression. We wanted to identify proteins, the expression of which would correlate with the formation of primordial follicles as a first step to determine their biological function in folliculogenesis. Proteins were extracted from embryonic (E15) and 8-day-old (P8) hamster ovaries and fractionated by two-dimensional gel electrophoresis. Gels were stained with Proteosilver, and images of protein profiles corresponding to E15 and P8 ovaries were overlayed to identify protein spots showing altered expression. Some of the protein spots were extracted from SyproRuby-stained preparative gels, digested with trypsin, and analyzed by mass spectrometry. Both E15 and P8 ovaries had high molecular weight proteins at acidic, basic, and neutral ranges; however, we focused on small molecular weight proteins at 4-7 pH range. Many of those spots might represent post-translational modification. Mass spectrometric analysis revealed the identity of these proteins. The formation of primordial follicles on P8 correlated with many differentially and newly expressed proteins. Whereas Ebp1 expression was downregulated in ovarian somatic cells, Sfrs3 expression was specifically upregulated in newly formed granulosa cells of primordial follicles on P8. The results show for the first time that the morphogenesis of primordial follicles in the hamster coincides with altered and novel expression of proteins involved in cell proliferation, transcriptional regulation, and metabolism. Therefore, formation of primordial follicles is an active process requiring differentiation of somatic cells into early granulosa cells and

  5. Cytokine (IL16) and tyrphostin actions on ovarian primordial follicle development.

    Science.gov (United States)

    Feeney, Amanda; Nilsson, Eric; Skinner, Michael K

    2014-09-01

    An ovarian follicle is composed of an oocyte and surrounding theca and granulosa cells. Oocytes are stored in an arrested state within primordial follicles until they are signaled to re-initiate development by undergoing primordial-to-primary follicle transition. Previous gene bionetwork analyses of primordial follicle development identified a number of critical cytokine signaling pathways and genes potentially involved in the process. In the current study, candidate regulatory genes and pathways from the gene network analyses were tested for their effects on the formation of primordial follicles (follicle assembly) and on primordial follicle transition using whole ovary organ culture experiments. Observations indicate that the tyrphostin inhibitor (E)-2-benzylidene-3-(cyclohexylamino)-2,3-dihydro-1H-inden-1-one increased follicle assembly significantly, supporting a role for the MAPK signaling pathway in follicle assembly. The cytokine interleukin 16 (IL16) promotes primordial-to-primary follicle transition as compared with the controls, where as Delta-like ligand 4 (DLL4) and WNT-3A treatments have no effect. Immunohistochemical experiments demonstrated the localization of both the cytokine IL16 and its receptor CD4 in the granulosa cells surrounding each oocyte within the ovarian follicle. The tyrphostin LDN193189 (LDN) is an inhibitor of the bone morphogenic protein receptor 1 within the TGFB signaling pathway and was found to promote the primordial-to-primary follicle transition. Observations support the importance of cytokines (i.e., IL16) and cytokine signaling pathways in the regulation of early follicle development. Insights into regulatory factors affecting early primordial follicle development are provided that may associate with ovarian disease and translate to improved therapy in the future. © 2014 Society for Reproduction and Fertility.

  6. White holes as the asymptotic limit of evaporating primordial black holes

    Science.gov (United States)

    Lee, Jeffrey S.; Cleaver, Gerald B.

    2016-10-01

    This paper examines the interaction of an intense fermion field with all of the particle species of an attometer primordial black hole’s (PBH) high energy Hawking radiation spectrum. By extrapolating to Planck-sized PBHs, it is shown that although Planck-sized PBHs closely simulate the zero absorption requirement of white holes, the absorption probability is not truly zero, and therefore, thermodynamically, Planck-sized primordial black holes are not true white holes.

  7. Implications of primordial power spectra with statistical anisotropy on CMB temperature fluctuation and polarizations

    CERN Document Server

    Chang, Zhe

    2013-01-01

    Both the Wilkinson Microwave Anisotropy Probe (WMAP) and Planck observations reported the hemispherical asymmetry of the cosmic microwave background (CMB) temperature fluctuation. The hemispherical asymmetry might be stemmed from the primordial statistical anisotropy during the inflationary era of the universe. In this paper, we study possible implications of the primordial power spectra with dipolar anisotropy on the CMB temperature fluctuation and polarizations. We explicitly show that the statistical dipolar anisotropy may induce the off-diagonal (\\(\\ell'\

  8. Evaluation of two putative susceptibility loci for oral clefts in the Danish population

    DEFF Research Database (Denmark)

    Mitchell, L E; Murray, J C; O'Brien, S;

    2001-01-01

    Previous studies suggest that the risk of nonsyndromic cleft lip with or without cleft palate (CL+/-P) and isolated cleft palate (CP) is influenced by genetic variation at several loci and that the relation between specific genetic variants and disease risk may be modified by environmental factors....... The present study evaluated potential associations between CL+/-P and CP and two putative clefting susceptibility loci, MSX1 and TGFB3, using data from a nationwide case-control study conducted in Denmark from 1991 to 1994. The potential effects of interactions between these genes and two common environmental...

  9. Vasoactive intestinal peptide can promote the development of neonatal rat primordial follicles during in vitro culture.

    Science.gov (United States)

    Chen, Niannian; Li, Yu; Wang, Wenjun; Ma, Yun; Yang, Dongzi; Zhang, Qingxue

    2013-01-01

    Recruitment of primordial follicles is essential for female fertility. Some of the intraovarian growth factors involved in the initiation of primordial follicle growth have been identified, but the exact mechanisms regulating follicle activation are poorly understood. Strong evidence indicates that vasoactive intestinal peptide (VIP), a neuropeptide found in ovarian nerves, plays a role in the physiology of follicle development and function. The aim of the present study was to determine whether VIP might regulate the activation and growth of neonatal rat primordial follicles in an in vitro culture system. Ovaries from 4-day-old rats were cultured for 14 days in medium containing 10(-7) M VIP. At the end of the culture, the developmental stages and viability of the follicles were evaluated using histological sections. Immunohistochemistry studies for proliferating cell nuclear antigen (PCNA) were performed to assess the mitotic activity of granulosa cells. In addition, the expression level of kit ligand (KL) mRNA was examined after culture. Histology showed that primordial follicles could survive and start to grow in vitro. The proportion of primordial follicles was decreased and the proportion of early primary follicles increased after in vitro culture with VIP. Immunolocalization of PCNA showed that follicle growth was initiated after VIP treatment. The expression level of KL mRNA was increased in the VIP treatment group. Thus, VIP can promote primordial follicle development, possibly mediated in part through upregulating the expression of KL.

  10. Ruling out the power-law form of the scalar primordial spectrum

    Energy Technology Data Exchange (ETDEWEB)

    Hazra, Dhiraj Kumar; Shafieloo, Arman [Asia Pacific Center for Theoretical Physics, Pohang, Gyeongbuk 790-784 (Korea, Republic of); Smoot, George F. [Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Starobinsky, Alexei A., E-mail: dhiraj@apctp.org, E-mail: arman@apctp.org, E-mail: gfsmoot@lbl.gov, E-mail: alstar@landau.ac.ru [Landau Institute for Theoretical Physics RAS, Moscow, 119334 (Russian Federation)

    2014-06-01

    Combining Planck CMB temperature [1] and BICEP2 B-mode polarization data [2,3] we show qualitatively that, assuming inflationary consistency relation, the power-law form of the scalar primordial spectrum is ruled out at more than 3σ CL. This is an important finding, since the power-law form of the scalar primordial spectrum is one of the main assumptions of concordance model of cosmology and also a direct prediction of many inflationary scenarios. We show that a break or step in the form of the primordial scalar perturbation spectrum, similar to what we studied recently analyzing Planck data [4], can address both Planck and BICEP2 results simultaneously. Our findings also indicate that the data may require more flexibilities than what running of scalar spectral index can provide. Finally we show that an inflaton potential, originally appeared in [5], can generate both the step and the break model of scalar primordial spectrum in two different limits. The discussed potential is found to be favored by Planck data but marginally disfavored by BICEP2 results as it produces slightly lower amplitude of tensor primordial spectrum. Hence, if the tensor-to-scalar ratio (r) quoted by BICEP2 persists, it is of importance that we generate inflationary models with large r and at the same time provide suppression in scalar primordial spectrum at large scales.

  11. GARD: a genetic algorithm for recombination detection

    National Research Council Canada - National Science Library

    Kosakovsky Pond, Sergei L; Posada, David; Gravenor, Michael B; Woelk, Christopher H; Frost, Simon D W

    2006-01-01

    .... We developed a likelihood-based model selection procedure that uses a genetic algorithm to search multiple sequence alignments for evidence of recombination breakpoints and identify putative recombinant sequences...

  12. Primordial Black Holes: Observational characteristics of the final evaporation

    Science.gov (United States)

    Ukwatta, T. N.; Stump, D. R.; Linnemann, J. T.; MacGibbon, J. H.; Marinelli, S. S.; Yapici, T.; Tollefson, K.

    2016-07-01

    Many early universe theories predict the creation of Primordial Black Holes (PBHs). PBHs could have masses ranging from the Planck mass to 105 solar masses or higher depending on the size of the universe at formation. A Black Hole (BH) has a Hawking temperature which is inversely proportional to its mass. Hence a sufficiently small BH will quasi-thermally radiate particles at an ever-increasing rate as emission lowers its mass and raises its temperature. The final moments of this evaporation phase should be explosive and its description is dependent on the particle physics model. In this work we investigate the final few seconds of BH evaporation, using the Standard Model and incorporating the most recent Large Hadron Collider (LHC) results, and provide a new parameterization for the instantaneous emission spectrum. We calculate for the first time energy-dependent PBH burst light curves in the GeV/TeV energy range. Moreover, we explore PBH burst search methods and potential observational PBH burst signatures. We have found a unique signature in the PBH burst light curves that may be detectable by GeV/TeV gamma-ray observatories such as the High Altitude Water Cerenkov (HAWC) observatory. The implications of beyond the Standard Model theories on the PBH burst observational characteristics are also discussed, including potential sensitivity of the instantaneous photon detection rate to a squark threshold in the 5-10 TeV range.

  13. Higgs vacuum metastability in primordial inflation, preheating, and reheating

    Science.gov (United States)

    Kohri, Kazunori; Matsui, Hiroki

    2016-11-01

    Current measurements of the Higgs boson mass and top Yukawa coupling suggest that the effective Higgs potential develops an instability below the Planck scale. If the energy scale of inflation is as high as the grand unified theory (GUT) scale, inflationary quantum fluctuations of the Higgs field can easily destabilize the standard electroweak vacuum and produce a lot of anti-de Sitter (AdS) domains. This destabilization during inflation can be avoided if a relatively large nonminimal Higgs-gravity or inflaton-Higgs coupling is introduced. Such couplings generate a large effective mass term for the Higgs, which can raise the effective Higgs potential and suppress the vacuum fluctuation of the Higgs field. After primordial inflation, however, such effective masses drops rapidly and the nonminimal Higgs-gravity or inflaton-Higgs coupling can cause large fluctuations of the Higgs field to be generated via parametric resonance, thus producing AdS domains in the preheating stage. Furthermore, thermal fluctuations of the Higgs field cannot be neglected in the proceeding reheating epoch. We discuss the Higgs vacuum fluctuations during inflation, preheating, and reheating, and show that the Higgs metastability problem is severe unless the energy scale of the inflaton potential is much lower than the GUT scale.

  14. Tracing Primordial Black Holes in Nonsingular Bouncing Cosmology

    CERN Document Server

    Chen, Jie-Wen; Xu, Hao-Lan; Cai, Yi-Fu

    2016-01-01

    We, in the present paper, investigate the formation and evolution of primordial black hole (PBH) within the scenario of nonsingular bouncing cosmology. We first analyze the PBH formation during the phase of matter contraction, which is different from that in an expanding background, and then evaluate the PBH abundance at the end of the contracting phase. Our result shows that it is generally small unless the energy scale parameter associated with the bouncing phase is as high as the Planck scale, i.e., $|H_{-}|\\gtrsim M_p$, or the sound speed parameter of cosmological perturbations is sufficiently small, which implies, $c_s \\ll 1$. Afterwards, we study the subsequent evolution of generating PBHs during the bouncing phase. For the PBH growth ignoring the Hawking radiation, a relation upon model parameters of the bouncing phase $\\Upsilon \\geq c_s^2 \\pi^2 H^2_{-}$ is expected to be satisfied, in case that PBHs would grow to infinity before the bouncing point. We also calculate the back-reaction of PBHs in order ...

  15. Current and Future Constraints on Primordial Magnetic Fields

    Science.gov (United States)

    Sutton, Dylan R.; Feng, Chang; Reichardt, Christian L.

    2017-09-01

    We present new limits on the amplitude of potential primordial magnetic fields (PMFs) using temperature and polarization measurements of the cosmic microwave background (CMB) from Planck, the BICEP2/Keck Array, Polarbear, and SPTpol. We reduce twofold the 95% confidence upper limit on the CMB anisotropy power due to a nearly scale-invariant PMF, with an allowed B-mode power at ℓ = 1500 of {D}{\\ell =1500}{BB}< 0.071 μ {K}2 for Planck versus {D}{\\ell =1500}{BB}< 0.034 μ {K}2 for the combined data set. We also forecast the expected limits from soon-to-deploy CMB experiments (like SPT-3G, Adv. ACTpol, or the Simons Array) and the proposed CMB-S4 experiment. Future CMB experiments should dramatically reduce the current uncertainties by one order of magnitude for the near-term experiments and two orders of magnitude for the CMB-S4 experiment. The constraints from CMB-S4 have the potential to rule out much of the parameter space for PMFs.

  16. Primordial black holes in linear and non-linear regimes

    CERN Document Server

    Allahyari, Alireza; Abolhasani, Ali Akbar

    2016-01-01

    Using the concept of apparent horizon for dynamical black holes, we revisit the formation of primordial black holes (PBH) in the early universe for both linear and non-linear regimes. First, we develop the perturbation theory for spherically symmetric spacetimes to study the formation of spherical PBHs in linear regime and we fix two gauges. We also introduce a well defined gauge invariant quantity for the expansion. Using this quantity, we argue that PBHs do not form in the linear regime. Finally, we study the non-linear regime. We adopt the spherical collapse picture by taking a closed FRW model in the radiation dominated era to investigate PBH formation. Taking the initial condition of the spherical collapse from the linear theory of perturbations, we allow for both density and velocity perturbations. Our model gives a constraint on the velocity perturbation. This model also predicts that the apparent horizon of PBHs forms when $\\delta > 3$. Applying the sound horizon constraint, we have shown the threshol...

  17. Generation of primordial magnetic fields on linear overdensity scales.

    Science.gov (United States)

    Naoz, Smadar; Narayan, Ramesh

    2013-08-02

    Magnetic fields appear to be present in all galaxies and galaxy clusters. Recent measurements indicate that a weak magnetic field may be present even in the smooth low density intergalactic medium. One explanation for these observations is that a seed magnetic field was generated by some unknown mechanism early in the life of the Universe, and was later amplified by various dynamos in nonlinear objects like galaxies and clusters. We show that a primordial magnetic field is expected to be generated in the early Universe on purely linear scales through vorticity induced by scale-dependent temperature fluctuations, or equivalently, a spatially varying speed of sound of the gas. Residual free electrons left over after recombination tap into this vorticity to generate magnetic field via the Biermann battery process. Although the battery operates even in the absence of any relative velocity between dark matter and gas at the time of recombination, the presence of such a relative velocity modifies the predicted spatial power spectrum of the magnetic field. At redshifts of order a few tens, we estimate a root mean square field strength of order 10(-25)-10(-24) G on comoving scales ~10 kpc. This field, which is generated purely from linear perturbations, is expected to be amplified significantly after reionization, and to be further boosted by dynamo processes during nonlinear structure formation.

  18. Planck 2015 results. XIX. Constraints on primordial magnetic fields

    CERN Document Server

    Ade, P.A.R.; Arnaud, M.; Arroja, F.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Ballardini, M.; Banday, A.J.; Barreiro, R.B.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J.J.; Bonaldi, A.; Bonavera, L.; Bond, J.R.; Borrill, J.; Bouchet, F.R.; Bucher, M.; Burigana, C.; Butler, R.C.; Calabrese, E.; Cardoso, J.-F.; Catalano, A.; Chamballu, A.; Chiang, H.C.; Chluba, J.; Christensen, P.R.; Church, S.; Clements, D.L.; Colombi, S.; Colombo, L.P.L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B.P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R.D.; Davis, R.J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Diego, J.M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T.A.; Eriksen, H.K.; Fergusson, J.; Finelli, F.; Florido, E.; Forni, O.; Frailis, M.; Fraisse, A.A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K.M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J.E.; Hansen, F.K.; Hanson, D.; Harrison, D.L.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S.R.; Hivon, E.; Hobson, M.; Holmes, W.A.; Hornstrup, A.; Hovest, W.; Huffenberger, K.M.; Hurier, G.; Jaffe, A.H.; Jaffe, T.R.; Jones, W.C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kim, J.; Kisner, T.S.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C.R.; Leahy, J.P.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P.B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P.M.; Macías-Pérez, J.F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P.G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P.R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Molinari, D.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J.A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C.B.; Nørgaard-Nielsen, H.U.; Noviello, F.; Novikov, D.; Novikov, I.; Oppermann, N.; Oxborrow, C.A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G.W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J.P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J.A.; Ruiz-Granados, B.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M.D.; Shellard, E.P.S.; Shiraishi, M.; Spencer, L.D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J.A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L.A.; Wandelt, B.D.; Wehus, I.K.; Yvon, D.; Zacchei, A.

    2016-01-01

    We predict and investigate four types of imprint of a stochastic background of primordial magnetic fields (PMFs) on the cosmic microwave background (CMB) anisotropies: the impact of PMFs on the CMB spectra; the effect on CMB polarization induced by Faraday rotation; magnetically-induced non-Gaussianities; and the magnetically-induced breaking of statistical isotropy. Overall, Planck data constrain the amplitude of PMFs to less than a few nanogauss. In particular, individual limits coming from the analysis of the CMB angular power spectra, using the Planck likelihood, are $B_{1\\,\\mathrm{Mpc}}< 4.4$ nG (where $B_{1\\,\\mathrm{Mpc}}$ is the comoving field amplitude at a scale of 1 Mpc) at 95% confidence level, assuming zero helicity, and $B_{1\\,\\mathrm{Mpc}}< 5.6$ nG when we consider a maximally helical field. For nearly scale-invariant PMFs we obtain $B_{1\\,\\mathrm{Mpc}}<2.1$ nG and $B_{1\\,\\mathrm{Mpc}}<0.7$ nG if the impact of PMFs on the ionization history of the Universe is included in the analysis...

  19. Planck 2015 results. XVII. Constraints on primordial non-Gaussianity

    CERN Document Server

    Ade, P.A.R.; Arnaud, M.; Arroja, F.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Ballardini, M.; Banday, A.J.; Barreiro, R.B.; Bartolo, N.; Basak, S.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.P.; Bersanelli, M.; Bielewicz, P.; Bock, J.J.; Bonaldi, A.; Bonavera, L.; Bond, J.R.; Borrill, J.; Bouchet, F.R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R.C.; Calabrese, E.; Cardoso, J.F.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H.C.; Christensen, P.R.; Church, S.; Clements, D.L.; Colombi, S.; Colombo, L.P.L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B.P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R.D.; Davis, R.J.; de Bernardis, P.; De Rosa, A.; De Zotti, G.; Delabrouille, J.; Désert, F.X.; Diego, J.M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T.A.; Eriksen, H.K.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A.A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Gauthier, C.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K.M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J.E.; Hamann, J.; Hansen, F.K.; Hanson, D.; Harrison, D.L.; Heavens, A.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S.R.; Hivon, E.; Hobson, M.; Holmes, W.A.; Hornstrup, A.; Hovest, W.; Huang, Z.; Huffenberger, K.M.; Hurier, G.; Jaffe, A.H.; Jaffe, T.R.; Jones, W.C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kim, J.; Kisner, T.S.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lacasa, F.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.M.; Lasenby, A.; Lattanzi, M.; Lawrence, C.R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Lewis, A.; Liguori, M.; Lilje, P.B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P.M.; Macías-Pérez, J.F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marinucci, D.; Maris, M.; Martin, P.G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P.R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Münchmeyer, M.; Munshi, D.; Murphy, J.A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C.B.; Nørgaard-Nielsen, H.U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C.A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Peiris, H.V.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G.W.; Prézeau, G.; Prunet, S.; Puget, J.L.; Rachen, J.P.; Racine, B.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J.A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Scott, D.; Seiffert, M.D.; Shellard, E.P.S.; Shiraishi, M.; Smith, K.; Spencer, L.D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutter, P.; Sutton, D.; Suur-Uski, A.S.; Sygnet, J.F.; Tauber, J.A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Troja, A.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; van Tent, B.; Vielva, P.; Villa, F.; Wade, L.A.; Wandelt, B.D.; Wehus, I.K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-01-01

    The Planck full mission cosmic microwave background(CMB) temperature and E-mode polarization maps are analysed to obtain constraints on primordial non-Gaussianity(NG). Using three classes of optimal bispectrum estimators - separable template-fitting (KSW), binned, and modal - we obtain consistent values for the local, equilateral, and orthogonal bispectrum amplitudes, quoting as our final result from temperature alone fNL^local=2.5+\\-5.7, fNL^equil=-16+\\-70 and fNL^ortho=-34+\\-33(68%CL). Combining temperature and polarization data we obtain fNL^local=0.8+\\-5.0, fNL^equil=-4+\\-43 and fNL^ortho=-26+\\-21 (68%CL). The results are based on cross-validation of these estimators on simulations, are stable across component separation techniques, pass an extensive suite of tests, and are consistent with Minkowski functionals based measurements. The effect of time-domain de-glitching systematics on the bispectrum is negligible. In spite of these test outcomes we conservatively label the results including polarization da...

  20. Primordial bispectrum from inflation with background gauge fields

    CERN Document Server

    Funakoshi, Hiroyuki

    2013-01-01

    We study the primordial bispectrum of curvature perturbation in the uniform-density slicing generated by the interaction between the inflaton and isotropic background gauge fields. We derive the action up to cubic order in perturbation and take into account all the relevant effects in the leading order of slow-roll expansion. We first treat the quadratic vertices perturbatively and confirm the results of past studies, while identifying their regime of validity. We then extend the analysis to include the effect of the quadratic vertices at all orders by introducing exact linear mode functions, allowing us to make a reliable prediction long after horizon crossing where the features of both power spectrum and bispectrum are drastically different. It is shown that the spectra become constant and scale invariant in the limit of large e-folding, which implies the model can be consistent with the observational constraints regardless of the magnitude of the background gauge fields. It is found that depending on the p...

  1. Testing for New Physics: Neutrinos and the Primordial Power Spectrum

    CERN Document Server

    Canac, Nicolas; Abazajian, Kevork N; Easther, Richard; Price, Layne C

    2016-01-01

    We test the sensitivity of neutrino parameter constraints from combinations of CMB and LSS data sets to the assumed form of the primordial power spectrum (PPS) using Bayesian model selection. Significantly, none of the tested combinations, including recent high-precision local measurements of $\\mathrm{H}_0$ and cluster abundances, indicate a signal for massive neutrinos or extra relativistic degrees of freedom. For PPS models with a large, but fixed number of degrees of freedom, neutrino parameter constraints do not change significantly if the location of any features in the PPS are allowed to vary, although neutrino constraints are more sensitive to PPS features if they are known a priori to exist at fixed intervals in $\\log k$. Although there is no support for a non-standard neutrino sector from constraints on both neutrino mass and relativistic energy density, we see surprisingly strong evidence for features in the PPS when it is constrained with data from Planck 2015, SZ cluster counts, and recent high-pr...

  2. Testing for new physics: neutrinos and the primordial power spectrum

    Science.gov (United States)

    Canac, Nicolas; Aslanyan, Grigor; Abazajian, Kevork N.; Easther, Richard; Price, Layne C.

    2016-09-01

    We test the sensitivity of neutrino parameter constraints from combinations of CMB and LSS data sets to the assumed form of the primordial power spectrum (PPS) using Bayesian model selection. Significantly, none of the tested combinations, including recent high-precision local measurements of H0 and cluster abundances, indicate a signal for massive neutrinos or extra relativistic degrees of freedom. For PPS models with a large, but fixed number of degrees of freedom, neutrino parameter constraints do not change significantly if the location of any features in the PPS are allowed to vary, although neutrino constraints are more sensitive to PPS features if they are known a priori to exist at fixed intervals in log k. Although there is no support for a non-standard neutrino sector from constraints on both neutrino mass and relativistic energy density, we see surprisingly strong evidence for features in the PPS when it is constrained with data from Planck 2015, SZ cluster counts, and recent high-precision local measurements of H0. Conversely combining Planck with matter power spectrum and BAO measurements yields a much weaker constraint. Given that this result is sensitive to the choice of data this tension between SZ cluster counts, Planck and H0 measurements is likely an indication of unmodeled systematic bias that mimics PPS features, rather than new physics in the PPS or neutrino sector.

  3. Corrections to halo model in presence of primordial magnetic field

    Science.gov (United States)

    Varalakshmi, Cheera; Nigam, Rahul

    2017-01-01

    We study the role played by the primordial magnetic field in the process of structure formation in the early universe. We have compared the halo mass abundance in the presence and absence of the magnetic field. We derive a modified Press-Schechter formula in presence of another source for matter perturbation and use it to study how this extra source affects halo count. This other source is the magnetic field with a given power spectrum. We find the ranges for the magnetic field strength over which the field enhances the halo formation for a mass range for spectral index nb = -2.95. We found that for field strength less than or equal to B = 7.0 nG, which we call the cut-off field strength, the presence of magnetic field enhances halo formation at low mass scale while it disrupts for a stronger field. We further investigate the dependence of halo count on the spectral index of the magnetic field power spectrum. We observe that at the cut-off field strength, halo formation is disrupted for a spectral index larger than -2.9. We carry out similar investigation for the more generic ellipsoidal collapse where the mass function is given by the Sheth-Tormen formula. For this case we find the cut-off field strength is 5.5 nG.

  4. Primordial black hole evaporation and spontaneous dimensional reduction

    Energy Technology Data Exchange (ETDEWEB)

    Mureika, J.R., E-mail: jmureika@lmu.edu [Department of Physics, Loyola Marymount University, Los Angeles, CA 90045 (United States)

    2012-09-17

    Several different approaches to quantum gravity suggest the effective dimension of spacetime reduces from four to two near the Planck scale. In light of such evidence, this Letter re-examines the thermodynamics of primordial black holes (PBHs) in specific lower-dimensional gravitational models. Unlike in four dimensions, (1+1)-D black holes radiate with power P{approx}M{sub BH}{sup 2}, while it is known no (2+1)-D (BTZ) black holes can exist in a non-anti-de Sitter universe. This has important relevance to the PBH population size and distribution, and consequently on cosmological evolution scenarios. The number of PBHs that have evaporated to present day is estimated, assuming they account for all dark matter. Entropy conservation during dimensional transition imposes additional constraints. If the cosmological constant is non-negative, no black holes can exist in the (2+1)-dimensional epoch, and consequently a (1+1)-dimensional black hole will evolve to become a new type of remnant. Although these results are conjectural and likely model-dependent, they open new questions about the viability of PBHs as dark matter candidates.

  5. Primordial chemistry and enzyme evolution in a hot environment.

    Science.gov (United States)

    Wolfenden, Richard

    2014-08-01

    Ever since the publication of Darwin's Origin of Species, questions have been raised about whether enough time has elapsed for living organisms to have reached their present level of complexity by mutation and natural selection. More recently, it has become apparent that life originated very early in Earth's history, and there has been controversy as to whether life originated in a hot or cold environment. This review describes evidence that rising temperature accelerates slow reactions disproportionately, and to a much greater extent than has been generally recognized. Thus, the time that would have been required for primordial chemistry to become established would have been abbreviated profoundly at high temperatures. Moreover, if the catalytic effect of a primitive enzyme (like that of modern enzymes) were to reduce a reaction's heat of activation, then the rate enhancement that it produced would have increased as the surroundings cooled, quite aside from changes arising from mutation (which is itself highly sensitive to temperature). Some nonenzymatic catalysts of slow reactions, including PLP as a catalyst of amino acid decarboxylation, and the Ce(IV) ion as a catalyst of phosphate ester hydrolysis, have been shown to meet that criterion. The work reviewed here suggests that elevated temperatures collapsed the time required for early evolution on Earth, furnishing an appropriate setting for exploring the vast range of chemical possibilities and for the rapid evolution of enzymes from primitive catalysts.

  6. Primordial power spectrum features in phenomenological descriptions of inflation

    CERN Document Server

    Gariazzo, Stefano; Ramirez, Hector; Boubekeur, Lotfi

    2016-01-01

    In this paper, we extend an alternative, phenomenological approach to inflation by means of an equation of state and a sound speed, both of them functions of the number of $e$-folds and three phenomenological parameters. This approach captures a number of possible inflationary models, including those with non-canonical kinetic terms or scale-dependent non-gaussianities. We perform Markov Chain Monte Carlo analyses using the latest cosmological publicly available measurements, which include Cosmic Microwave Background (CMB) data from the Planck satellite. In the context of the phenomenological description studied here, the sound speed of the primordial curvature perturbation is found to be $c_s> 0.2$ at $95\\%$~CL for a number of $e$-folds $N=60$. Within this parametrization, we discard scale invariance with a significance of about $10\\sigma$, and the running of the spectral index is constrained as $\\alpha_s=-0.62\\,^{+0.08}_{-0.09} \\times 10^{-3}$. The limit on the tensor-to-scalar ratio is $r<0.003$ at $95\\...

  7. Primordial monopoles, proton decay, gravity waves and GUT inflation

    CERN Document Server

    Şenoğuz, Vedat Nefer

    2016-01-01

    We consider non-supersymmetric GUT inflation models in which intermediate mass monopoles may survive inflation because of the restricted number of e-foldings experienced by the accompanying symmetry breaking. Thus, an observable flux of primordial magnetic monopoles, comparable to or a few orders below the Parker limit, may be present in the galaxy. The mass scale associated with the intermediate symmetry breaking is $10^{13}$ GeV for an observable flux level, with the corresponding monopoles an order of magnitude or so heavier. Examples based on $SO(10)$ and $E_6$ yield such intermediate mass monopoles carrying respectively two and three units of Dirac magnetic charge. For GUT inflation driven by a gauge singlet scalar field with a Coleman-Weinberg or Higgs potential, compatibility with the Planck measurement of the scalar spectral index yields a Hubble constant (during horizon exit of cosmological scales) $H \\sim 7$--$9\\times10^{13}$ GeV, with the tensor to scalar ratio $r$ predicted to be $\\gtrsim0.02$. Pr...

  8. Gamma-Rays from Ultracompact Primordial Dark Matter Minihalos

    CERN Document Server

    Scott, Pat

    2009-01-01

    Primordially-laid ultracompact minihalos (PLUMs) have recently been proposed as a new class of dark matter structure. PLUMs would be produced by phase transitions in the early Universe, and constitute non-baryonic massive compact halo objects (MACHOs) today. We examine the prospects for detecting PLUMs in gamma-rays if dark matter consists of self-annihilating particles. We compute present-day fluxes from PLUMs produced in the electroweak and QCD phase transitions in the early universe, and from the electron-positron annihilation epoch. PLUMs produced during the electron-positron epoch should be eminently detectable today, either by the Fermi satellite, current Air Cherenkov telescopes, or even in archival data from EGRET. If they exist within 2 kpc of Earth, PLUMs from the electron-positron epoch should also appear as extended sources to Fermi. PLUMs formed in the QCD phase transition have similar predicted fluxes to the dwarf spheroidal galaxies targeted by current indirect searches for dark matter, and mig...

  9. Sensitivity of HAWC to Primordial Black Hole Bursts

    CERN Document Server

    Ukwatta, T N; MacGibbon, D Stump J H; Marinelli, S S; Yapici, T; Tollefson, K

    2015-01-01

    Primordial Black Holes (PBHs) are black holes that may have been created in the early Universe and could be as large as supermassive black holes or as small as the Planck scale. It is believed that a black hole has a temperature inversely proportional to its mass and will thermally emit all species of fundamental particles. PBHs with initial masses of 5.0 x 10^14 g should be expiring today with bursts of high-energy gamma radiation in the GeV/TeV energy range. The High Altitude Water Cherenkov (HAWC) observatory is sensitive to the high end of the PBH gamma-ray burst spectrum. Due to its large field of view, duty cycle above 90% and sensitivity up to 100 TeV, the HAWC observatory is well suited to perform a search for PBH bursts. We report that if the PBH explodes within 0.25 light years from Earth and within 26 degrees of zenith, HAWC will have a 95% probability of detecting the PBH burst at the 5 sigma level. Conversely, a null detection from a 2 year or longer HAWC search will set PBH upper limits which ar...

  10. A pilgrim's progress: Seeking meaning in primordial germ cell migration.

    Science.gov (United States)

    Cantú, Andrea V; Laird, Diana J

    2017-07-18

    Comparative studies of primordial germ cell (PGC) development across organisms in many phyla reveal surprising diversity in the route of migration, timing and underlying molecular mechanisms, suggesting that the process of migration itself is conserved. However, beyond the perfunctory transport of cellular precursors to their later arising home of the gonads, does PGC migration serve a function? Here we propose that the process of migration plays an additional role in quality control, by eliminating PGCs incapable of completing migration as well as through mechanisms that favor PGCs capable of responding appropriately to migration cues. Focusing on PGCs in mice, we explore evidence for a selective capacity of migration, considering the tandem regulation of proliferation and migration, cell-intrinsic and extrinsic control, the potential for tumors derived from failed PGC migrants, the potential mechanisms by which migratory PGCs vary in their cellular behaviors, and corresponding effects on development. We discuss the implications of a selective role of PGC migration for in vitro gametogenesis. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  11. Cultivation and Biological Characterization of Chicken Primordial Germ Cells

    Directory of Open Access Journals (Sweden)

    Meng Ji

    2016-01-01

    Full Text Available The purpose of this work was to investigate the isolation, culture process of chicken gonadal primordial germ cells (PGCs and study their biological characterization. PGCs were harvested from 5.5-day-old chicken embryonic genital ridges and explanted onto chicken embryonic fibroblasts (CEFs. The results showed that the primary cultivation of chicken PGCs on their own gonadal stroma cells were better than CEFs at first two days for reproduction. The conditioned media supported the growth and colony formation of PGCs for a prolonged time in vitro and maintained a normal diploid karyotype, which were positively stained by alkaline phosphatase (AKP, periodic acid Schiff (PAS and reacted with anti-SSEA-1, SSEA-3, Oct4, Blimp1 and Sox2. Real-time PCR showed that they expressed the stage specific genes CVH, Blimp1 and Dazl, the stem cell specific genes Sox2, Pouv and Nanog. They also formed the embryoid bodies (EBs. These results suggested that the chicken PGCs cultured in vitro not only had strong self-renewal ability, but also had the potential capability of multi-lineage differentiation.

  12. The Early Evolution of Primordial Pair-Instability Supernovae

    CERN Document Server

    Joggerst, C C

    2010-01-01

    The observational signatures of the first cosmic explosions and their chemical imprint on second-generation stars both crucially depend on how heavy elements mix within the star at the earliest stages of the blast. We present numerical simulations of the early evolution of Population III pair-instability supernovae with the new adaptive mesh refinement code CASTRO. In stark contrast to 15 - 40 Msun core-collapse primordial supernovae, we find no mixing in most 150 - 250 Msun pair-instability supernovae out to times well after breakout from the surface of the star. This may be the key to determining the mass of the progenitor of a primeval supernova, because vigorous mixing will cause emission lines from heavy metals such as Fe and Ni to appear much sooner in the light curves of core-collapse supernovae than in those of pair-instability explosions. Our results also imply that unlike low-mass Pop III supernovae, whose collective metal yields can be directly compared to the chemical abundances of extremely metal...

  13. Interspecific germline transmission of cultured primordial germ cells.

    Directory of Open Access Journals (Sweden)

    Marie-Cecile van de Lavoir

    Full Text Available In birds, the primordial germ cell (PGC lineage separates from the soma within 24 h following fertilization. Here we show that the endogenous population of about 200 PGCs from a single chicken embryo can be expanded one million fold in culture. When cultured PGCs are injected into a xenogeneic embryo at an equivalent stage of development, they colonize the testis. At sexual maturity, these donor PGCs undergo spermatogenesis in the xenogeneic host and become functional sperm. Insemination of semen from the xenogeneic host into females from the donor species produces normal offspring from the donor species. In our model system, the donor species is chicken (Gallus domesticus and the recipient species is guinea fowl (Numida meleagris, a member of a different avian family, suggesting that the mechanisms controlling proliferation of the germline are highly conserved within birds. From a pragmatic perspective, these data are the basis of a novel strategy to produce endangered species of birds using domesticated hosts that are both tractable and fecund.

  14. Primordial gas cooling behind shock waves in merging halos

    CERN Document Server

    Vasiliev, E O; Shchekinov, Yu.A.

    2006-01-01

    We investigate thermal regime of the baryons behind shock waves arising in the process of virialization of dark matter halos. We find a fraction of the shocked gas cooled by radiation of HD molecules down to the temperature of the cosmic microwave background (CMB): this fraction increases sharply from about $f_{\\rm c}\\sim 10^{-3}$ for dark halos of $M=5\\times 10^7\\msun$ to $\\sim 0.1$ for halos with $M=10^8\\msun$ at $z=10$. We show, however, that further increase of the mass does not lead to a significant growth of $f_{\\rm c}$ -- the assymptotic value for $M\\gg 10^8\\msun$ is of 0.2. We estimate star formation rate associated with such shock waves, and show that it can be a small but not negligible fraction of the star formation connected with cooling by HI and H$_2$. We argue that extremely metal-poor low-mass stars in the Milky Way may have been formed from primordial gas behind such shocks.

  15. Low-temperature primordial gas in merging halos

    CERN Document Server

    Vasiliev, E O

    2008-01-01

    Thermal regime of the baryons behind shock waves arising in the process of virialization of dark matter halos is governed at cetrain conditions by radiation of HD lines. A small fraction of the shocked gas can cool down to the temperature of the cosmic microwave background (CMB). We estimate an upper limit for this fraction: at $z=10$ it increases sharply from about $q_{_T}\\sim 10^{-3}$ for dark halos of $M=5\\times 10^7\\msun$ to $\\sim 0.1$ for halos with $M=10^8\\msun$. Further increase of the halo mass does not lead however to a significant growth of $q_T$ -- the asymptotic value for $M\\gg 10^8\\msun$ is of 0.3. We estimate star formation rate associated with such shock waves, and show that they can provide a small but not negligible fraction of the star formation. We argue that extremely metal-poor low-mass stars in the Milky Way may have been formed from primordial gas behind such shocks.

  16. Formation of Massive Primordial Stars in a Reionized Gas

    CERN Document Server

    Yoshida, Naoki; Hernquist, Lars

    2007-01-01

    We use cosmological hydrodynamic simulations with unprecedented resolution to study the formation of primordial stars in an ionized gas at high redshifts. Our approach includes all the relevant atomic and molecular physics to follow the thermal evolution of a prestellar gas cloud to very high densities of ~10^{18} cm^{-3}. We locate a star-forming gas cloud within a reionized region in our cosmological simulation. The first run-away collapse is triggered when the gas cloud's mass is ~40 Msun. We show that the cloud core remains stable against chemo-thermal instability and also against gravitational deformation throughout its evolution. Consequently, a single proto-stellar seed is formed, which accretes the surrounding hot gas at the rate ~10^{-3} Msun/year. We carry out proto-stellar evolution calculations using the inferred accretion rate. The resulting mass of the star when it reaches the zero-age main sequence is M_ZAMS ~ 40 Msun. We argue that, since the obtained M_ZAMS is as large as the mass of the coll...

  17. The formation of massive primordial stars in rapidly rotating disks

    CERN Document Server

    Latif, M A

    2014-01-01

    Massive primordial halos exposed to moderate UV backgrounds are the potential birthplaces of very massive stars or even supermassive black holes. In such a halo, an initially isothermal collapse will occur, leading to high accretion rates of $\\sim0.1$~M$_\\odot$~yr$^{-1}$. During the collapse, the gas in the interior will turn into a molecular state, and form an accretion disk due to the conservation of angular momentum. We consider here the structure of such an accretion disk and the role of viscous heating in the presence of high accretion rates for a central star of $10$, $100$ and $10^4$~M$_\\odot$. Our results show that the temperature in the disk increases considerably due to viscous heating, leading to a transition from the molecular to the atomic cooling phase. We found that the atomic cooling regime may extend out to several $100$~AU for a $10^4$~M$_\\odot$ central star and provides substantial support to stabilize the disk. It therefore favors the formation of a massive central object. The comparison o...

  18. The state of globular clusters at birth II: primordial binaries

    CERN Document Server

    Leigh, Nathan W C; Marks, Michael; Webb, Jeremy J; Hypki, Arkadiusz; Heinke, Craig O; Kroupa, Pavel; Sills, Alison

    2014-01-01

    (abridged) In this paper, we constrain the properties of primordial binary populations in Galactic globular clusters using the MOCCA Monte Carlo code for cluster evolution. Our results are compared to the observations of Milone et al. (2012) using the photometric binary populations as proxies for the true underlying distributions, in order to test the hypothesis that the data are consistent with an universal initial binary fraction near unity and the binary orbital parameter distributions of Kroupa (1995). With the exception of a few possible outliers, we find that the data are to first-order consistent with the universality hypothesis. Specifically, the present-day binary fractions inside the half-mass radius r$_{\\rm h}$ can be reproduced assuming either high initial binary fractions near unity with a dominant soft binary component as in the Kroupa distribution combined with high initial densities (10$^4$-10$^6$ M$_{\\odot}$ pc$^{-3}$), or low initial binary fractions ($\\sim$ 5-10%) with a dominant hard binar...

  19. QUBIC: A Fizeau Interferometer Targeting Primordial B-Modes

    Science.gov (United States)

    Tartari, A.; Aumont, J.; Banfi, S.; Battaglia, P.; Battistelli, E. S.; Baù, A.; Bélier, B.; Bennett, D.; Bergé, L.; Bernard, J. Ph.; Bersanelli, M.; Bigot-Sazy, M. A.; Bleurvacq, N.; Bordier, G.; Brossard, J.; Bunn, E. F.; Buzi, D.; Cammilleri, D.; Cavaliere, F.; Chanial, P.; Chapron, C.; Coppolecchia, A.; D'Alessandro, G.; De Bernardis, P.; Decourcelle, T.; Del Torto, F.; De Petris, M.; Dumoulin, L.; Franceschet, C.; Gault, A.; Gayer, D.; Gervasi, M.; Ghribi, A.; Giard, M.; Giraud-Héraud, Y.; Gradziel, M.; Grandsire, L.; Hamilton, J. Ch.; Haynes, V.; Holtzer, N.; Kaplan, J.; Korotkov, A.; Lande, J.; Lowitz, A.; Maffei, B.; Marnieros, S.; Martino, J.; Masi, S.; McCulloch, M.; Melhuish, S.; Mennella, A.; Montier, L.; Murphy, A.; Néel, D.; Ng, M. W.; O'Sullivan, C.; Pajot, F.; Passerini, A.; Perbost, C.; Piacentini, F.; Piat, M.; Piccirillo, L.; Pisano, G.; Prêle, D.; Rambaud, D.; Rigaut, O.; Salatino, M.; Schillaci, A.; Scully, S.; Stolpovskiy, M. M.; Timbie, P.; Tucker, G.; Viganò, D.; Voisin, F.; Watson, B.; Zannoni, M.

    2016-08-01

    Q and U Bolometric Interferometer for Cosmology (QUBIC) is a Fizeau interferometer sensitive to linear polarisation, to be deployed at the Antarctic station of Dome C. This experiment in its final configuration will be operated at 97, 150 and 220 GHz and is intended to target CMB primordial B-modes in a multipole window 20<ℓ <150. A sensitivity of r = 0.05 (95 % CL) can be reached by the first module alone, after 2 years of operation. Here we review in particular its working principles, and we show how the QUBIC interferometric configuration can be considered equivalent to a pupil-plane filtered imaging system. In this context, we show how our instrument can be self-calibrated. Finally, we conclude by showing an overview of the first dual-band module (150/220 GHz), which will serve also as a demonstrator for the subsequent units, and review the technological choices we made for each subsystem, with particular emphasis on the detection system.

  20. Fermi LAT Limits on Primordial Black Hole Evaporation

    Science.gov (United States)

    Johnson, Chistian; Malyshev, Dmitry; Funk, Stefan; Ritz, Steven; Fermi LAT Collaboration

    2017-01-01

    Primordial black holes (PBHs) of sufficiently small mass emit gamma rays in the Fermi Large Area Telescope (LAT) energy range. PBHs with lifetimes shorter than the Fermi observation time will appear as moving point sources with gamma-ray emission that becomes harder and brighter with time until the PBH completely evaporates. Previous searches for gamma rays from PBHs have focused on either short time scale bursts or the contribution of PBH bursts to the isotropic diffuse emission. Here we use Fermi LAT point source catalogs to search for PBH candidates that evaporate on a time scale of several years. In addition to looking for the spectral signatures of a PBH, we also develop an algorithm to detect proper motion. There are a few unassociated point sources with spectra consistent with PBH evaporation; however, none of these sources show significant proper motion. We derive a conservative limit on PBH evaporation rate in the vicinity of the Earth by using a threshold on the gamma-ray flux above 10 GeV such that there are no sources above this threshold with spectra consistent with Hawking radiation from PBHs. The derived limit is more stringent than the limits obtained with ground-based gamma-ray observatories.

  1. Supernova explosions in magnetized, primordial dark matter halos

    CERN Document Server

    Seifried, D; Schleicher, D

    2013-01-01

    We present a set of high resolution simulations studying the effect of supernova explosions on magnetized, primordial halos. We focus on the evolution of an initially small-scale magnetic field formed during the collapse of the halo. We vary the degree of magnetization, the halo mass, and the amount of explosion energy in order to account for expected variations as well as to infer systematical dependencies of the results on initial conditions. Our simulations suggest that core collapse supernovae with an explosion energy of 10^51 erg and more violent pair instability supernovae with 10^53 erg are able to disrupt halos with masses up to a few 10^6 and 10^7 M_sun, respectively. The peak of the magnetic field spectra shows a continuous shift towards smaller k-values, i.e. larger length scales, over time reaching values as low as k = 4. On small scales the magnetic energy decreases at the cost of the energy on large scales resulting in well-ordered magnetic field with strengths up to about 10^-8 G depending on t...

  2. Hydrogen peroxide thermochemical oscillator as driver for primordial RNA replication.

    Science.gov (United States)

    Ball, Rowena; Brindley, John

    2014-06-06

    This paper presents and tests a previously unrecognized mechanism for driving a replicating molecular system on the prebiotic earth. It is proposed that cell-free RNA replication in the primordial soup may have been driven by self-sustained oscillatory thermochemical reactions. To test this hypothesis, a well-characterized hydrogen peroxide oscillator was chosen as the driver and complementary RNA strands with known association and melting kinetics were used as the substrate. An open flow system model for the self-consistent, coupled evolution of the temperature and concentrations in a simple autocatalytic scheme is solved numerically, and it is shown that thermochemical cycling drives replication of the RNA strands. For the (justifiably realistic) values of parameters chosen for the simulated example system, the mean amount of replicant produced at steady state is 6.56 times the input amount, given a constant supply of substrate species. The spontaneous onset of sustained thermochemical oscillations via slowly drifting parameters is demonstrated, and a scheme is given for prebiotic production of complementary RNA strands on rock surfaces.

  3. Primordial features due to a step in the inflaton potential

    CERN Document Server

    Hazra, Dhiraj Kumar; Jain, Rajeev Kumar; Sriramkumar, L; Souradeep, Tarun

    2010-01-01

    Certain oscillatory features in the primordial scalar power spectrum are known to provide a better fit to the outliers in the cosmic microwave background data near the multipole moments of $\\ell=22$ and 40. These features are usually generated by introducing a step in the popular, quadratic potential describing the canonical scalar field. Such a model will be ruled out, if the tensors remain undetected at a level corresponding to a tensor-to-scalar ratio of, say, $r\\simeq 0.1$. In this work, in addition to the popular quadratic potential, we investigate the effects of the step in a small field model and a tachyon model. With possible applications to future datasets (such as PLANCK) in mind, we evaluate the tensor power spectrum exactly, and include its contribution in our analysis. We compare the models with the WMAP (five as well as seven-year), the QUaD and the ACBAR data. As expected, a step at a particular location and of a suitable magnitude and width is found to improve the fit to the outliers (near $\\e...

  4. Reheating and Primordial Gravitational Waves in Generalized Galilean Genesis

    CERN Document Server

    Nishi, Sakine

    2016-01-01

    Galilean genesis is an alternative to inflation, in which the universe starts expanding from Minkowski with the stable violation of the null energy condition. In this paper, we discuss how the early universe is reheated through the gravitational particle production at the trasition from the genesis phase to the subsequent phase where the kinetic energy of the scalar field is dominant. We then study the consequences of gravitational reheating after Galilean genesis on the spectrum of primordial gravitational waves. The resultant spectrum is strongly blue, and at high frequencies $\\Omega_{\\rm gw}\\propto f^3$ in terms of the energy density per unit logarithmic frequency. Though this cannot be detected in existing detctors, the amplitude can be as large as $\\Omega_{\\rm gw}\\sim 10^{-12}$ at $f\\sim 100\\,$MHz, providing a future test of the genesis scenario. The analysis is performed within the framework of generalized Galilean genesis based on the Horndeski theory, which enables us to derive generic formulas.

  5. Precision measures of the primordial abundance of deuterium

    CERN Document Server

    Cooke, Ryan; Jorgenson, Regina A; Murphy, Michael T; Steidel, Charles C

    2013-01-01

    We report the discovery of deuterium absorption in the very metal-poor ([Fe/H] = -2.87) damped Lyman-alpha system at z_abs = 3.06726 towards the QSO SDSS J1358+6522. On the basis of 13 resolved D I absorption lines and the damping wings of the H I Lyman alpha transition, we have obtained a new, precise measure of the primordial abundance of deuterium. Furthermore, to bolster the present statistics of precision D/H measures, we have reanalyzed all of the known deuterium absorption-line systems that satisfy a set of strict criteria. We have adopted a blind analysis strategy (to remove human bias), and developed a software package that is specifically designed for precision D/H abundance measurements. For this reanalyzed sample of systems, we obtain a weighted mean of (D/H)_p = (2.53 +/- 0.04) x 10^-5, corresponding to a Universal baryon density 100 Omega_b h^2 = 2.202 +/- 0.045 for the standard model of Big Bang Nucleosynthesis. By combining our measure of (D/H)_p with observations of the cosmic microwave backg...

  6. Gene expression profiling of chicken primordial germ cell ESTs

    Directory of Open Access Journals (Sweden)

    Lim Dajeong

    2006-08-01

    Full Text Available Abstract Background Germ cells are the only cell type that can penetrate from one generation to next generation. At the early embryonic developmental stages, germ cells originally stem from primordial germ cells, and finally differentiate into functional gametes, sperm in male or oocyte in female, after sexual maturity. This study was conducted to investigate a large-scale expressed sequence tag (EST analysis in chicken PGCs and compare the expression of the PGC ESTs with that of embryonic gonad. Results We constructed 10,851 ESTs from a chicken cDNA library of a collection of highly separated embryonic PGCs. After chimeric and problematic sequences were filtered out using the chicken genomic sequences, there were 5,093 resulting unique sequences consisting of 156 contigs and 4,937 singlets. Pearson chi-square tests of gene ontology terms in the 2nd level between PGC and embryonic gonad set showed no significance. However, digital gene expression profiling using the Audic's test showed that there were 2 genes expressed significantly with higher number of transcripts in PGCs compared with the embryonic gonads set. On the other hand, 17 genes in embryonic gonads were up-regulated higher than those in the PGC set. Conclusion Our results in this study contribute to knowledge of mining novel transcripts and genes involved in germline cell proliferation and differentiation at the early embryonic stages.

  7. Lyman-Werner UV escape fractions from primordial haloes

    Science.gov (United States)

    Schauer, Anna T. P.; Whalen, Daniel J.; Glover, Simon C. O.; Klessen, Ralf S.

    2015-12-01

    Population III (Pop III) stars can regulate star formation in the primordial Universe in several ways. They can ionize nearby haloes, and even if their ionizing photons are trapped by their own haloes, their Lyman-Werner (LW) photons can still escape and destroy H2 in other haloes, preventing them from cooling and forming stars. LW escape fractions are thus a key parameter in cosmological simulations of early reionization and star formation but have not yet been parametrized for realistic haloes by halo or stellar mass. To do so, we perform radiation hydrodynamical simulations of LW UV escape from 9-120 M⊙ Pop III stars in 105-107 M⊙ haloes with ZEUS-MP. We find that photons in the LW lines (i.e. those responsible for destroying H2 in nearby systems) have escape fractions ranging from 0 to 85 per cent. No LW photons escape the most massive halo in our sample, even from the most massive star. Escape fractions for photons elsewhere in the 11.18-13.6 eV energy range, which can be redshifted into the LW lines at cosmological distances, are generally much higher, being above 60 per cent for all but the least massive stars in the most massive haloes. We find that shielding of H2 by neutral hydrogen, which has been neglected in most studies to date, produces escape fractions that are up to a factor of 3 smaller than those predicted by H2 self-shielding alone.

  8. Cholesterol induces proliferation of chicken primordial germ cells.

    Science.gov (United States)

    Chen, Dongyang; Chen, Meijuan; Lu, Zhenping; Yang, Mengmeng; Xie, Long; Zhang, Wenxin; Xu, Huiyan; Lu, Kehuan; Lu, Yangqing

    2016-08-01

    Primordial germ cells (PGCs) are the precursors of sperm and eggs and may serve as suitable cells for use in research in developmental biology and transgenic animals. However, the long-term propagation of PGCs in vitro has so far been plagued by the loss of their germ cell characteristics. This is largely because of the scarcity of knowledge concerning cell division and proliferation in these cells and the poor optimization of the culture medium. The sonic hedgehog (SHH) signaling pathway is involved in proliferation of many types of cells, but little is known about its role in chicken PGCs. The results of the current study indicate that the proliferation of chicken PGCs increases significantly when cholesterol, a molecule that facilitates the trafficking of HH ligands, is supplemented in the culture medium. This effect was attenuated when an SHH antagonist, cyclopamine was added, suggesting the involvement of SHH signaling in this process. The characterization of PGCs treated with cholesterol has shown that these cells express germ-cell-related markers and retain their capability to colonize the embryonic gonad after re-introduction to vasculature of stage-15 HH embryos, indicating that proliferation of PGCs induced by cholesterol does not alter the germ cell characteristics of these cells.

  9. A primordial star in the heart of the Lion

    CERN Document Server

    Caffau, E; François, P; Spite, M; Spite, F; Zaggia, S; Ludwig, H -G; Steffen, M; Mashonkina, L; Monaco, L; Sbordone, L; Molaro, P; Cayrel, R; Plez, B; Hill, V; Hammer, F; Randich, S

    2012-01-01

    Context: The discovery and chemical analysis of extremely metal-poor stars permit a better understanding of the star formation of the first generation of stars and of the Universe emerging from the Big Bang. aims: We report the study of a primordial star situated in the centre of the constellation Leo (SDSS J102915+172027). method: The star, selected from the low resolution-spectrum of the Sloan Digital Sky Survey, was observed at intermediate (with X-Shooter at VLT) and at high spectral resolution (with UVES at VLT). The stellar parameters were derived from the photometry. The standard spectroscopic analysis based on 1D ATLAS models was completed by applying 3D and non-LTE corrections. results: An iron abundance of [Fe/H]=--4.89 makes SDSS J102915+172927 one of the lowest [Fe/H] stars known. However, the absence of measurable C and N enhancements indicates that it has the lowest metallicity, Z<= 7.40x10^{-7} (metal-mass fraction), ever detected. No oxygen measurement was possible. conclusions: The discove...

  10. Lyman-Werner UV Escape Fractions from Primordial Halos

    CERN Document Server

    Schauer, Anna T P; Glover, Simon C O; Klessen, Ralf S

    2015-01-01

    Population III stars can regulate star formation in the primordial Universe in several ways. They can ionize nearby halos, and even if their ionizing photons are trapped by their own halos, their Lyman-Werner (LW) photons can still escape and destroy H$_2$ in other halos, preventing them from cooling and forming stars. LW escape fractions are thus a key parameter in cosmological simulations of early reionization and star formation but have not yet been parametrized for realistic halos by halo or stellar mass. To do so, we perform radiation hydrodynamical simulations of LW UV escape from 9--120 M$_{\\odot}$ Pop III stars in $10^5$ to $10^7$ M$_{\\odot}$ halos with ZEUS-MP. We find that photons in the LW lines (i.e. those responsible for destroying H$_{2}$ in nearby systems) have escape fractions ranging from 0% to 85%. No LW photons escape the most massive halo in our sample, even from the most massive star. Escape fractions for photons elsewhere in the 11.18--13.6~eV energy range, which can be redshifted into t...

  11. The chemical evolution of self-gravitating primordial disks

    CERN Document Server

    Schleicher, Dominik R G; Latif, Muhammad A; Ferrara, Andrea; Grassi, Tommaso

    2016-01-01

    Numerical simulations show the formation of self-gravitating primordial disks during the assembly of the first structures in the Universe, in particular during the formation of Pop. III and supermassive stars. Their subsequent evolution is expected to be crucial to determine the mass scale of the first cosmological objects, which depends on the temperature of the gas and the dominant cooling mechanism. Here, we derive a one-zone framework to explore the chemical evolution of such disks and show that viscous heating leads to the collisional dissociation of an initially molecular gas. The effect is relevant on scales of 10 AU (1000 AU) for a central mass of 10 M_solar (10^4 M_solar) at an accretion rate of 0.1 M_solar/yr, and provides a substantial heat input to stabilize the disk. If the gas is initially atomic, it remains atomic during the further evolution, and the effect of viscous heating is less significant. The additional thermal support is particularly relevant for the formation of very massive objects,...

  12. Primordial Globular Clusters, X-Ray Binaries & Cosmological Reionisation

    CERN Document Server

    Power, C; Combet, C; Wilkinson, M I

    2009-01-01

    Globular clusters are dense stellar systems that have typical ages of ~13 billion years, implying that they formed at redshifts of z>~6. Massive stars in newly formed or primordial globular clusters could have played an important role during the epoch of cosmological reionisation (z>~6) as sources of energetic, neutral hydrogen ionising UV photons. We investigate whether or not these stars could have been as important in death as sources of energetic X-ray photons as they were during their main sequence lives. Most massive stars are expected to form in binaries, and an appreciable fraction of these (as much as ~30%) will evolve into X-ray luminous (L_X~10^38 erg/s) high-mass X-ray binaries (HMXBs). These sources would have made a contribution to the X-ray background at z>~6. Using Monte Carlo models of a globular cluster, we estimate the total X-ray luminosity of a population of HMXBs. We compare and contrast this with the total UV luminosity of the massive stars during their main sequence lives. For reasonab...

  13. Primordial nucleosynthesis during the keV era

    Energy Technology Data Exchange (ETDEWEB)

    Dimopoulos, S.; Esmailzadeh, R.; Hall, L.J.; Starkman, G.D.

    1987-09-09

    Energetic hadronic and electromagnetic showers in the keV era of the hot big bang are produced by the decays of long lived particles. These showers initiate a new phase of nucleosynthesis. The abundance ratios of D, /sup 3/He, /sup 6/Li and /sup 7/Li are given by fixed points of rate equations, which are determined by nuclear physics not by the nature of the decaying particle. The fixed points are independent of prior abundances, so that constraints from the MeV era of nucleosynthesis evaporate, except for a requirement that /sup 4/He not be underproduced. For example, ..cap omega../sub B/ = 1 and many more than four neutrino species are both possible. Within the accuracy of our calculation (there are uncertainties of at least a factor of three), the abundances agree with those inferred from observations. Considerable /sup 6/Li is produced and must be depleted in both population II halo stars and in the galactic disk. We predict /sup 6/Li, /sup 3/He and D abundances in primordial material which are higher than conventional nucleosynthesis. 8 refs.

  14. Primordial magnetic fields from self-ordering scalar fields

    CERN Document Server

    Horiguchi, Kouichirou; Sekiguchi, Toyokazu; Sugiyama, Naoshi

    2015-01-01

    A symmetry-breaking phase transition in the early universe could have led to the formation of cosmic defects. Because these defects dynamically excite not only scalar and tensor type cosmological perturbations but also vector type ones, they may serve as a source of primordial magnetic fields. In this study, we calculate the time evolution and the spectrum of magnetic fields that are generated by a type of cosmic defects, called global textures, using the non-linear sigma (NLSM) model. Based on the standard cosmological perturbation theory, we show, both analytically and numerically, that a vector-mode relative velocity between photon and baryon fluids is induced by textures, which inevitably leads to the generation of magnetic fields over a wide range of scales. We find that the amplitude of the magnetic fields is given by $B\\sim{10^{-9}}{((1+z)/10^3)^{-2.5}}({v}/{m_{\\rm pl}})^2({k}/{\\rm Mpc^{-1}})^{3.5}/{\\sqrt{N}}$ Gauss in the radiation dominated era for $k\\lesssim 1$ Mpc$^{-1}$, with $v$ being the vacuum ...

  15. Formation and cultivation of medaka primordial germ cells.

    Science.gov (United States)

    Li, Zhendong; Li, Mingyou; Hong, Ni; Yi, Meisheng; Hong, Yunhan

    2014-07-01

    Primordial germ cell (PGC) formation is pivotal for fertility. Mammalian PGCs are epigenetically induced without the need for maternal factors and can also be derived in culture from pluripotent stem cells. In egg-laying animals such as Drosophila and zebrafish, PGCs are specified by maternal germ plasm factors without the need for inducing factors. In these organisms, PGC formation and cultivation in vitro from indeterminate embryonic cells have not been possible. Here, we report PGC formation and cultivation in vitro from blastomeres dissociated from midblastula embryos (MBEs) of the fish medaka (Oryzias latipes). PGCs were identified by using germ-cell-specific green fluorescent protein (GFP) expression from a transgene under the control of the vasa promoter. Embryo perturbation was exploited to study PGC formation in vivo, and dissociated MBE cells were cultivated under various conditions to study PGC formation in vitro. Perturbation of somatic development did not prevent PGC formation in live embryos. Dissociated MBE blastomeres formed PGCs in the absence of normal somatic structures and of known inducing factors. Most importantly, under culture conditions conducive to stem cell derivation, some dissociated MBE blastomeres produced GFP-positive PGC-like cells. These GFP-positive cells contained genuine PGCs, as they expressed PGC markers and migrated into the embryonic gonad to generate germline chimeras. Our data thus provide evidence for PGC preformation in medaka and demonstrate, for the first time, that PGC formation and derivation can be obtained in culture from early embryos of medaka as a lower vertebrate model.

  16. Primordial monopoles, proton decay, gravity waves and GUT inflation

    Directory of Open Access Journals (Sweden)

    Vedat Nefer Şenoğuz

    2016-01-01

    Full Text Available We consider non-supersymmetric GUT inflation models in which intermediate mass monopoles may survive inflation because of the restricted number of e-foldings experienced by the accompanying symmetry breaking. Thus, an observable flux of primordial magnetic monopoles, comparable to or a few orders below the Parker limit may be present in the galaxy. The mass scale associated with the intermediate symmetry breaking is 1013 GeV for an observable flux level, with the corresponding monopoles an order of magnitude or so heavier. Examples based on SO(10 and E6 yield such intermediate mass monopoles carrying respectively two and three units of Dirac magnetic charge. For GUT inflation driven by a gauge singlet scalar field with a Coleman–Weinberg or Higgs potential, compatibility with the Planck measurement of the scalar spectral index yields a Hubble constant (during horizon exit of cosmological scales H∼7–9×1013 GeV, with the tensor to scalar ratio r predicted to be ≳0.02. Proton lifetime estimates for decays mediated by the superheavy gauge bosons are also provided.

  17. Multimode Bolometer Development for the Primordial Inflation Explorer (PIXIE) Instrument

    Science.gov (United States)

    Nagler, Peter C.; Crowley, Kevin T.; Denis, Kevin L.; Devasia, Archana M.; Fixsen, Dale J.; Kogut, Alan J.; Manos, George; Porter, Scott; Stevenson, Thomas R.

    2016-01-01

    The Primordial Inflation Explorer (PIXIE) is an Explorer-class mission concept designed to measure the polarization and absolute intensity of the cosmic microwave background [1]. In this work, we report on the design, fabrication, and performance of the multimode polarization-sensitive bolometers for PIXIE, which are based on silicon thermistors. In particular we focus on several recent advances in the detector design, including the implementation of a tensioning scheme to greatly raise the frequencies of the internal vibrational modes of the large-area, low-mass optical absorber structure consisting of a grid of micromachined, ion-implanted silicon wires. With 30 times the absorbing area of the spider-web bolometers used by Planck, the tensioning scheme enables the PIXIE bolometers to be robust in the vibrational and acoustic environment at launch of the space mission. More generally, it could be used to reduce microphonic sensitivity in other types of low temperature detectors. We also report on the performance of the PIXIE bolometers in a dark cryogenic environment.

  18. Over-expression of a putative oxidoreductase (UcpA) for increasing furfural or 5-hydroxymethylfurfural tolerance

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Xuan; Miller, Elliot N.; Yomano, Lorraine P.; Shanmugam, Keelnatham T.; Ingram, Lonnie O' Neal

    2016-05-24

    The subject invention pertains to overexpression of a putative oxidoreductase (ucpA) for increasing furfural tolerance in genetically modified microorganisms. Genetically modified microorganisms capable of overexpressing UcpA are also provided. Increased expression of ucpA was shown to increase furfural tolerance by 50%, and to permit the fermentation of sugars to products in the presence of 15 mM furfural.

  19. Putative Nitrogen Sensing Systems in Higher Plants

    Institute of Scientific and Technical Information of China (English)

    Hon-Ming Lam; Ying Ann Chiao; Man-Wah Li; Yuk-Kwong Yung; Sang Ji

    2006-01-01

    Nitrogen (N) metabolism is essential for the biosynthesis of vital biomolecules. N status thus exerts profound effects on plant growth and development, and must be closely monitored. In bacteria and fungi, a few sophisticated N sensing systems have been extensively studied. In animals, the ability to receive amino acid signals has evolved to become an integral part of the nervous coordination system. In this review, we will summarize recent developments in the search for putative N sensing systems in higher plants based on homologous systems in bacteria, fungi, and animals. Apparently, although plants have separated and diversified from other organisms during the evolution process, striking similarities can be found in their N sensing systems compared with those of their counterparts; however, our understanding of these systems is still incomplete. Significant modifications of the N sensing systems (including cross-talk with other signal transduction pathways) in higher plants may be a strategy of adaptation to their unique mode of life.

  20. Putative respiratory chain of Porphyromonas gingivalis.

    Science.gov (United States)

    Meuric, Vincent; Rouillon, Astrid; Chandad, Fatiha; Bonnaure-Mallet, Martine

    2010-05-01

    The electron transfer chain in Porphyromonas gingivalis, or periodontopathogens, has not yet been characterized. P. gingivalis, a strict anaerobic bacteria and the second colonizer of the oral cavity, is considered to be a major causal agent involved in periodontal diseases. Primary colonizers create a favorable environment for P. gingivalis growth by decreasing oxygen pressure. Oxygen does not appear to be the final electron acceptor of the respiratory chain. Fumarate and cytochrome b have been implicated as major components of the respiratory activity. However, the P. gingivalis genome shows many other enzymes that could be implicated in aerobic or nitrite respiration. Using bioinformatic tools and literature studies of respiratory pathways, the ATP synthesis mechanism from the sodium cycle and nutrients metabolism, the putative respirasome of P. gingivalis has been proposed.

  1. BRCA-1 Gene Expression and Comparative Proteomic Profile of Primordial Follicles from Young and Adult Buffalo (Bubalus bubalis) Ovaries.

    Science.gov (United States)

    Govindaraj, Vijayakumar; Krishnagiri, Harshini; Chauhan, Manmohan Singh; Rao, A J

    2017-04-03

    In our previous study, we demonstrated that the repair efficiency of DNA double-strand breaks declines with increasing age in rat primordial follicles. In the present study, we extended our studies to buffalo (Bubalus bubalis) wherein we studied the expression of BRCA-1 related DNA repair genes in primordial follicles of young (12 months-22 months) and adult (72-96 months) buffaloes. The relative expression of selected genes, as determined by RT-PCR, revealed a significant (p primordial follicles as compared to the young. Western blot analysis revealed a significant (p primordial follicles. The protein expression profile of young and adult buffalo primordial follicles revealed differential expression of proteins involved in mitochondrial function, cell survival and cell metabolism. Similar to reports from aging rodent and human primordial follicles, our findings support the fact that impairment of DNA repair may be an universal mechanism involved in oocyte aging.

  2. Formation of germline chimera Gaok chicken used circulation primordial germ cells (circulation PGCs fresh and thawed

    Directory of Open Access Journals (Sweden)

    Kostaman T

    2014-03-01

    Full Text Available Formation of germline chimeras by transfer of chicken primordial germ cells (PGCs is one of the effective techniques for preservation and regeneration of genetic resources in chickens. This study attempted to form germline chimeras of Gaok chicken buy purifying circulated PGCs of donor embryo before it is transferred to the recipient (White Leghorn chickens=WL and studied the ability of recipient embryo on survival in incubators, and hatchability. This study used 200 fertile eggs of Gaok and 90 fertile WL breed all of the eggs was incubated at 380C and 60% humidity in a portable incubator. PGCs-circulation of the blood collected Gaok embryos at stage 14-16 were taken from the dorsal aorta, and then purified by centrifugation method using nycodenz. PGCs-circulation results further purification frozen in liquid nitrogen before being transferred to the recipient embryo. The results showed that for the development of embryos transferred to the fresh circulation of PGCs-circulation as many as 25 cells can survive up to day 14, while one of the transferred of 50 and 100 cells into recipient embryos was hatched (10%. On the contrari recipient embryos that are transferred to the frozen PGCs-circulation the embryos development was shorter, and only survived until day 10th (treatment 25 cells, day 14th (treatment of 50 cells and day 17th (treatment of 100 cells. It is concluded that the amount of PGCs-circulation embryos transferred to the recipient is one factor that influence the success of the development germline chimeras.

  3. De Novo GMNN Mutations Cause Autosomal-Dominant Primordial Dwarfism Associated with Meier-Gorlin Syndrome.

    Science.gov (United States)

    Burrage, Lindsay C; Charng, Wu-Lin; Eldomery, Mohammad K; Willer, Jason R; Davis, Erica E; Lugtenberg, Dorien; Zhu, Wenmiao; Leduc, Magalie S; Akdemir, Zeynep C; Azamian, Mahshid; Zapata, Gladys; Hernandez, Patricia P; Schoots, Jeroen; de Munnik, Sonja A; Roepman, Ronald; Pearring, Jillian N; Jhangiani, Shalini; Katsanis, Nicholas; Vissers, Lisenka E L M; Brunner, Han G; Beaudet, Arthur L; Rosenfeld, Jill A; Muzny, Donna M; Gibbs, Richard A; Eng, Christine M; Xia, Fan; Lalani, Seema R; Lupski, James R; Bongers, Ernie M H F; Yang, Yaping

    2015-12-03

    Meier-Gorlin syndrome (MGS) is a genetically heterogeneous primordial dwarfism syndrome known to be caused by biallelic loss-of-function mutations in one of five genes encoding pre-replication complex proteins: ORC1, ORC4, ORC6, CDT1, and CDC6. Mutations in these genes cause disruption of the origin of DNA replication initiation. To date, only an autosomal-recessive inheritance pattern has been described in individuals with this disorder, with a molecular etiology established in about three-fourths of cases. Here, we report three subjects with MGS and de novo heterozygous mutations in the 5' end of GMNN, encoding the DNA replication inhibitor geminin. We identified two truncating mutations in exon 2 (the 1(st) coding exon), c.16A>T (p.Lys6(∗)) and c.35_38delTCAA (p.Ile12Lysfs(∗)4), and one missense mutation, c.50A>G (p.Lys17Arg), affecting the second-to-last nucleotide of exon 2 and possibly RNA splicing. Geminin is present during the S, G2, and M phases of the cell cycle and is degraded during the metaphase-anaphase transition by the anaphase-promoting complex (APC), which recognizes the destruction box sequence near the 5' end of the geminin protein. All three GMNN mutations identified alter sites 5' to residue Met28 of the protein, which is located within the destruction box. We present data supporting a gain-of-function mechanism, in which the GMNN mutations result in proteins lacking the destruction box and hence increased protein stability and prolonged inhibition of replication leading to autosomal-dominant MGS.

  4. Novel microcephalic primordial dwarfism disorder associated with variants in the centrosomal protein ninein.

    Science.gov (United States)

    Dauber, Andrew; Lafranchi, Stephen H; Maliga, Zoltan; Lui, Julian C; Moon, Jennifer E; McDeed, Cailin; Henke, Katrin; Zonana, Jonathan; Kingman, Garrett A; Pers, Tune H; Baron, Jeffrey; Rosenfeld, Ron G; Hirschhorn, Joel N; Harris, Matthew P; Hwa, Vivian

    2012-11-01

    Microcephalic primordial dwarfism (MPD) is a rare, severe form of human growth failure in which growth restriction is evident in utero and continues into postnatal life. Single causative gene defects have been identified in a number of patients with MPD, and all involve genes fundamental to cellular processes including centrosome functions. The objective of the study was to find the genetic etiology of a novel presentation of MPD. The design of the study was whole-exome sequencing performed on two affected sisters in a single family. Molecular and functional studies of a candidate gene were performed using patient-derived primary fibroblasts and a zebrafish morpholino oligonucleotides knockdown model. Two sisters presented with a novel subtype of MPD, including severe intellectual disabilities. NIN, encoding Ninein, a centrosomal protein critically involved in asymmetric cell division, was identified as a candidate gene, and functional impacts in fibroblasts and zebrafish were studied. From 34,606 genomic variants, two very rare missense variants in NIN were identified. Both probands were compound heterozygotes. In the zebrafish, ninein knockdown led to specific and novel defects in the specification and morphogenesis of the anterior neuroectoderm, resulting in a deformity of the developing cranium with a small, squared skull highly reminiscent of the human phenotype. We identified a novel clinical subtype of MPD in two sisters who have rare variants in NIN. We show, for the first time, that reduction of ninein function in the developing zebrafish leads to specific deficiencies of brain and skull development, offering a developmental basis for the myriad phenotypes in our patients.

  5. Roles of Gremlin 1 and Gremlin 2 in regulating ovarian primordial to primary follicle transition.

    Science.gov (United States)

    Nilsson, Eric E; Larsen, Ginger; Skinner, Michael K

    2014-06-01

    A network of extracellular signaling factors has previously been shown to act in concert to control the ovarian primordial to primary follicle transition. The current study was designed to investigate the roles of the endogenous bone morphogenetic protein (BMP) inhibitors Gremlin 1 (GREM1) and GREM2 in primordial follicle transition in the rat ovary. GREM1 and GREM2 treatments were found to reverse the effects of anti-Müllerian hormone (AMH) to inhibit follicle transition in a whole-ovary culture system. GREM1 reversed the effect of BMP4 to stimulate primordial follicle transition. Immunohistochemical studies showed that GREM2, but not GREM1, was present in primordial follicles suggesting that GREM2 may regulate primordial follicle transition in vivo. Co-immunoprecipitation studies indicated that GREM2 directly binds to AMH, as well as to BMP4. Transcriptome analyses of ovaries treated with GREM2 or GREM1 yielded negligible numbers of differentially expressed genes, suggesting that the immediate effects of GREM2 or GREM1 appear to be at the level of protein-protein interactions, rather than direct actions on the cells. A number of other ovarian growth factors were found to influence the expression of Grem2. Observations suggest that Grem2 is a part of the signaling network of growth factors that regulate the primordial to primary follicle transition. Insights into the regulatory networks affecting the pool of primordial follicles are important to understand the molecular basis for reproductive diseases such as primary ovarian insufficiency. © 2014 Society for Reproduction and Fertility.

  6. Alginate encapsulation supports the growth and differentiation of human primordial follicles within ovarian cortical tissue.

    Science.gov (United States)

    Laronda, Monica M; Duncan, Francesca E; Hornick, Jessica E; Xu, Min; Pahnke, Jennifer E; Whelan, Kelly A; Shea, Lonnie D; Woodruff, Teresa K

    2014-08-01

    In vitro follicle growth (IVFG) is an investigational fertility preservation technique in which immature follicles are grown in culture to produce mature eggs that can ultimately be fertilized. Although progress has been made in growing primate primary and secondary follicles in vitro, it has been a relatively greater challenge to isolate and culture primordial follicles. The purpose of this study was to develop methods to grow human primordial follicles in vitro using alginate hydrogels. We obtained human ovarian tissue for research purposes through the National Physicians Cooperative from nationwide sites and used it to test two methods for culturing primordial follicles. First, primordial follicles were isolated from the ovarian cortex and encapsulated in alginate hydrogels. Second, 1 mm × 1 mm pieces of 500 μm-thick human ovarian cortex containing primordial follicles were encapsulated in alginate hydrogels, and survival and follicle development within the tissue was assessed for up to 6 weeks. We found that human ovarian tissue could be kept at 4 °C for up to 24 h while still maintaining follicle viability. Primordial follicles isolated from ovarian tissue did not survive culture. However, encapsulation and culture of ovarian cortical pieces supported the survival, differentiation, and growth of primordial and primary follicles. Within several weeks of culture, many of the ovarian tissue pieces had formed a defined surface epithelium and contained growing preantral and antral follicles. The early stages of in vitro human follicle development require the support of the native ovarian cortex.

  7. Somatic cells initiate primordial follicle activation and govern the development of dormant oocytes in mice.

    Science.gov (United States)

    Zhang, Hua; Risal, Sanjiv; Gorre, Nagaraju; Busayavalasa, Kiran; Li, Xin; Shen, Yan; Bosbach, Benedikt; Brännström, Mats; Liu, Kui

    2014-11-03

    The majority of oocytes in the mammalian ovary are dormant oocytes that are enclosed in primordial follicles by several somatic cells, which we refer to as primordial follicle granulosa cells (pfGCs). Very little is known, however, about how the pfGCs control the activation of primordial follicles and the developmental fates of dormant oocytes. By targeting molecules in pfGCs with several mutant mouse models, we demonstrate that the somatic pfGCs initiate the activation of primordial follicles and govern the quiescence or awakening of dormant oocytes. Inhibition of mTORC1 signaling in pfGCs prevents the differentiation of pfGCs into granulosa cells, and this arrests the dormant oocytes in their quiescent states, leading to oocyte death. Overactivation of mTORC1 signaling in pfGCs accelerates the differentiation of pfGCs into granulosa cells and causes premature activation of all dormant oocytes and primordial follicles. We further show that pfGCs trigger the awakening of dormant oocytes through KIT ligand (KITL), and we present an essential communication network between the somatic cells and germ cells that is based on signaling between the mTORC1-KITL cascade in pfGCs and KIT-PI3K signaling in oocytes. Our findings provide a relatively complete picture of how mammalian primordial follicles are activated. The microenvironment surrounding primordial follicles can activate mTORC1-KITL signaling in pfGCs, and these cells trigger the awakening of dormant oocytes and complete the process of follicular activation. Such communication between the microenvironment, somatic cells, and germ cells is essential to maintaining the proper reproductive lifespan in mammals. Copyright © 2014 Elsevier Ltd. All rights reserved.

  8. A new determination of the primordial helium abundance

    Science.gov (United States)

    Peimbert, M.; Peimbert, A.; Luridiana, V.

    2017-07-01

    We present new Y values for five H II regions, from these values we determine the primordial helium abundance, YP, and obtain that YP = 0.2446 ± 0.0029, (Peimbert, A. et al. 2016, RMxAA, 52, 419). The main difference of our new value with the YP value by Peimbert, M. et al. (2007, ApJ , 666, 633) is due to the use of updated atomic physics parameters. Our YP value is consistent with that by Aver, E. et al. (2015, JCAP, 7, 11), that amounts to YP = 0.2449 ± 0.0040, but in disagreement by more than 3σ with that by Izotov, Y. I. et al. (2014, MNRAS, 443, 778), that amounts to YP = 0.2551 ± 0.0022. YP together with Big Bang Nucleosynthesis, BBN, can be used to put constraints on the number of neutrino families, Nν, and the neutron mean life, τn. The adoption of a neutron mean life of τn = 880.3 ± 1.1 (s) (Olive, K. A et al. 2014, Chinese Physics C, 38, 090001) and our YP value imply that Neff = 2.90 ± 0.22, consistent with 3 neutrino families but not with 4 neutrino families. The adoption of Neff = 3.046 (Mangano, G. and Serpico, P. D. 2011, PhLB, 701, 296) and our YP value imply that τn = 872 ± 14 (s), consistent with both high and low values of τn in the literature. An increase on the quality of the YP determination from H II regions will provide stronger constraints on the Nν and τn values.

  9. The state of globular clusters at birth - II. Primordial binaries

    Science.gov (United States)

    Leigh, Nathan W. C.; Giersz, Mirek; Marks, Michael; Webb, Jeremy J.; Hypki, Arkadiusz; Heinke, Craig O.; Kroupa, Pavel; Sills, Alison

    2015-01-01

    In this paper, we constrain the properties of primordial binary populations in Galactic globular clusters. Using the MOCCA Monte Carlo code for cluster evolution, our simulations cover three decades in present-day total cluster mass. Our results are compared to the observations of Milone et al. using the photometric binary populations as proxies for the true underlying distributions, in order to test the hypothesis that the data are consistent with a universal initial binary fraction near unity and the binary orbital parameter distributions of Kroupa. With the exception of a few possible outliers, we find that the data are to first-order consistent with the universality hypothesis. Specifically, the present-day binary fractions inside the half-mass radius can be reproduced assuming either high initial binary fractions near unity with a dominant soft binary component as in the Kroupa distribution combined with high initial densities (104-106 M⊙ pc-3), or low initial binary fractions (˜5-10 per cent) with a dominant hard binary component combined with moderate initial densities near their present-day values (102-103 M⊙ pc-3). This apparent degeneracy can potentially be broken using the binary fractions outside the half-mass radius - only high initial binary fractions with a significant soft component combined with high initial densities can reproduce the observed anticorrelation between the binary fractions outside the half-mass radius and the total cluster mass. We further illustrate using the simulated present-day binary orbital parameter distributions and the technique first introduced in Leigh et al. that the relative fractions of hard and soft binaries can be used to further constrain both the initial cluster density and the initial mass-density relation. Our results favour an initial mass-density relation of the form r_h ∝ M_clus^{α } with α < 1/3, corresponding to an initial correlation between cluster mass and density.

  10. The Origin of Large Molecules in Primordial Autocatalytic Reaction Networks

    Science.gov (United States)

    Giri, Varun; Jain, Sanjay

    2012-01-01

    Large molecules such as proteins and nucleic acids are crucial for life, yet their primordial origin remains a major puzzle. The production of large molecules, as we know it today, requires good catalysts, and the only good catalysts we know that can accomplish this task consist of large molecules. Thus the origin of large molecules is a chicken and egg problem in chemistry. Here we present a mechanism, based on autocatalytic sets (ACSs), that is a possible solution to this problem. We discuss a mathematical model describing the population dynamics of molecules in a stylized but prebiotically plausible chemistry. Large molecules can be produced in this chemistry by the coalescing of smaller ones, with the smallest molecules, the ‘food set’, being buffered. Some of the reactions can be catalyzed by molecules within the chemistry with varying catalytic strengths. Normally the concentrations of large molecules in such a scenario are very small, diminishing exponentially with their size. ACSs, if present in the catalytic network, can focus the resources of the system into a sparse set of molecules. ACSs can produce a bistability in the population dynamics and, in particular, steady states wherein the ACS molecules dominate the population. However to reach these steady states from initial conditions that contain only the food set typically requires very large catalytic strengths, growing exponentially with the size of the catalyst molecule. We present a solution to this problem by studying ‘nested ACSs’, a structure in which a small ACS is connected to a larger one and reinforces it. We show that when the network contains a cascade of nested ACSs with the catalytic strengths of molecules increasing gradually with their size (e.g., as a power law), a sparse subset of molecules including some very large molecules can come to dominate the system. PMID:22238620

  11. On the Maximum Mass of Accreting Primordial Supermassive Stars

    Science.gov (United States)

    Woods, T. E.; Heger, Alexander; Whalen, Daniel J.; Haemmerlé, Lionel; Klessen, Ralf S.

    2017-06-01

    Supermassive primordial stars are suspected to be the progenitors of the most massive quasars at z ˜ 6. Previous studies of such stars were either unable to resolve hydrodynamical timescales or considered stars in isolation, not in the extreme accretion flows in which they actually form. Therefore, they could not self-consistently predict their final masses at collapse, or those of the resulting supermassive black hole seeds, but rather invoked comparison to simple polytropic models. Here, we systematically examine the birth, evolution, and collapse of accreting, non-rotating supermassive stars under accretion rates of 0.01-10 M ⊙ yr-1 using the stellar evolution code Kepler. Our approach includes post-Newtonian corrections to the stellar structure and an adaptive nuclear network and can transition to following the hydrodynamic evolution of supermassive stars after they encounter the general relativistic instability. We find that this instability triggers the collapse of the star at masses of 150,000-330,000 M ⊙ for accretion rates of 0.1-10 M ⊙ yr-1, and that the final mass of the star scales roughly logarithmically with the rate. The structure of the star, and thus its stability against collapse, is sensitive to the treatment of convection and the heat content of the outer accreted envelope. Comparison with other codes suggests differences here may lead to small deviations in the evolutionary state of the star as a function of time, that worsen with accretion rate. Since the general relativistic instability leads to the immediate death of these stars, our models place an upper limit on the masses of the first quasars at birth.

  12. Hip pathology in Majewski osteodysplastic primordial dwarfism type II.

    Science.gov (United States)

    Karatas, Ali F; Bober, Michael B; Rogers, Kenneth; Duker, Angela L; Ditro, Colleen P; Mackenzie, William G

    2014-09-01

    Majewski osteodysplastic primordial dwarfism type II (MOPDII) is characterized by severe prenatal and postnatal growth failure with microcephaly, characteristic skeletal dysplasia, an increased risk for cerebrovascular disease, and insulin resistance. MOPDII is caused by mutations in the pericentrin (PCNT) gene and is inherited in an autosomal-recessive manner. This study aimed to determine the incidence of hip pathology in patients with molecularly confirmed MOPDII and to describe the functional outcomes of surgical treatment. Thirty-three enrolled patients had a clinical diagnosis of MOPDII. Biallelic PCNT mutations or absent pericentrin protein was confirmed in 25 of these patients. Twelve patients (7 female) had appropriate clinical and radiographic records at this institution and were included in this study. The data collected included age at presentation, age at surgery, sex, body weight and height, weight-bearing status at diagnosis, and the clinical examination. Four patients (31%) had coxa vara: 3 unilateral and 1 bilateral. Three unilateral patients had in situ pinning at a mean age 4 years. The patient with bilateral coxa vara had valgus osteotomy at the age of 5 years. Two children had bilateral hip dysplasia and subluxation with no surgery. One patient had bilateral developmental hip dislocations. The patient was treated by open reduction-spica cast and 2 years after surgery, coxa valga was noted. Another patient was diagnosed at an age of 12 years with bilateral avascular necrosis of the hips. Four patients did not have hip pathology. Hip pathology is common among children with MOPDII; coxa vara is the most frequent diagnosis. Routine clinical and radiographic hip evaluation is important. The capital femoral epiphysis appears to slip down along the shaft, giving the appearance of a proximal femoral epiphysiolysis. A hip diagnosed with slipped capital femoral epiphysis in early life may progress to severe coxa vara. Level IV.

  13. Putative bronchopulmonary flagellated protozoa in immunosuppressed patients.

    Science.gov (United States)

    Kilimcioglu, Ali Ahmet; Havlucu, Yavuz; Girginkardesler, Nogay; Celik, Pınar; Yereli, Kor; Özbilgin, Ahmet

    2014-01-01

    Flagellated protozoa that cause bronchopulmonary symptoms in humans are commonly neglected. These protozoal forms which were presumed to be "flagellated protozoa" have been previously identified in immunosuppressed patients in a number of studies, but have not been certainly classified so far. Since no human cases of bronchopulmonary flagellated protozoa were reported from Turkey, we aimed to investigate these putative protozoa in immunosuppressed patients who are particularly at risk of infectious diseases. Bronchoalveolar lavage fluid samples of 110 immunosuppressed adult patients who were admitted to the Department of Chest Diseases, Hafsa Sultan Hospital of Celal Bayar University, Manisa, Turkey, were examined in terms of parasites by light microscopy. Flagellated protozoal forms were detected in nine (8.2%) of 110 cases. Metronidazole (500 mg b.i.d. for 30 days) was given to all positive cases and a second bronchoscopy was performed at the end of the treatment, which revealed no parasites. In conclusion, immunosuppressed patients with bronchopulmonary symptoms should attentively be examined with regard to flagellated protozoa which can easily be misidentified as epithelial cells.

  14. The Biogeography of Putative Microbial Antibiotic Production.

    Directory of Open Access Journals (Sweden)

    Hélène Morlon

    Full Text Available Understanding patterns in the distribution and abundance of functional traits across a landscape is of fundamental importance to ecology. Mapping these distributions is particularly challenging for species-rich groups with sparse trait measurement coverage, such as flowering plants, insects, and microorganisms. Here, we use likelihood-based character reconstruction to infer and analyze the spatial distribution of unmeasured traits. We apply this framework to a microbial dataset comprised of 11,732 ketosynthase alpha gene sequences extracted from 144 soil samples from three continents to document the spatial distribution of putative microbial polyketide antibiotic production. Antibiotic production is a key competitive strategy for soil microbial survival and performance. Additionally, novel antibiotic discovery is highly relevant to human health, making natural antibiotic production by soil microorganisms a major target for bioprospecting. Our comparison of trait-based biogeographical patterns to patterns based on taxonomy and phylogeny is relevant to our basic understanding of microbial biogeography as well as the pressing need for new antibiotics.

  15. Mechanosensory neurons, cutaneous mechanoreceptors, and putative mechanoproteins.

    Science.gov (United States)

    Del Valle, M E; Cobo, T; Cobo, J L; Vega, J A

    2012-08-01

    The mammalian skin has developed sensory structures (mechanoreceptors) that are responsible for different modalities of mechanosensitivity like touch, vibration, and pressure sensation. These specialized sensory organs are anatomically and functionally connected to a special subset of sensory neurons called mechanosensory neurons, which electrophysiologically correspond with Aβ fibers. Although mechanosensory neurons and cutaneous mechanoreceptors are rather well known, the biology of the sense of touch still remains poorly understood. Basically, the process of mechanosensitivity requires the conversion of a mechanical stimulus into an electrical signal through the activation of ion channels that gate in response to mechanical stimuli. These ion channels belong primarily to the family of the degenerin/epithelium sodium channels, especially the subfamily acid-sensing ion channels, and to the family of transient receptor potential channels. This review compiles the current knowledge on the occurrence of putative mechanoproteins in mechanosensory neurons and mechanoreceptors, as well as the involvement of these proteins on the biology of touch. Furthermore, we include a section about what the knock-out mice for mechanoproteins are teaching us. Finally, the possibilities for mechanotransduction in mechanoreceptors, and the common involvement of the ion channels, extracellular membrane, and cytoskeleton, are revisited.

  16. Further insight into reproductive incompatibility between putative cryptic species of the Bemisia tabaci whitefly complex.

    Science.gov (United States)

    Qin, Li; Pan, Li-Long; Liu, Shu-Sheng

    2016-04-01

    The whitefly Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae), with its global distribution and extensive genetic diversity, is now known to be a complex of over 35 cryptic species. However, a satisfactory resolution of the systematics of this species complex is yet to be achieved. Here, we designed experiments to examine reproductive compatibility among species with different levels of mitochondrial cytochrome oxidase I (mtCOI) divergence. The data show that putative species with mtCOI divergence of >8% between them consistently exhibited complete reproductive isolation. However, two of the putative species, Asia II 9 and Asia II 3, with mtCOI divergence of 4.47% between them, exhibited near complete reproductive compatibility in one direction of their cross, and partial reproductive compatibility in the other direction. Together with some recent reports on this topic from the literature, our data indicates that, while divergence in the mtCOI sequences provides a valid molecular marker for species delimitation in most clades, more genetic markers and more sophisticated molecular phylogeny will be required to achieve adequate delimitation of all species in this whitefly complex. While many attempts have been made to examine the reproductive compatibility among genetic groups of the B. tabaci complex, our study represents the first effort to conduct crossing experiments with putative species that were chosen with considerations of their genetic divergence. In light of the new data, we discuss the best strategy and protocols to conduct further molecular phylogenetic analysis and crossing trials, in order to reveal the overall pattern of reproductive incompatibility among species of this whitefly complex.

  17. The Atacama Cosmology Telescope: A Measurement of the Primordial Power Spectrum

    Science.gov (United States)

    Hlozek, Renee; Dunkley, Joanna; Addison, Graeme; Appel, John William; Bond, J. Richard; Carvalho, C. Sofia; Das, Sudeep; Devlin, Mark J.; Duenner, Rolando; Essinger-Hileman, Thomas; hide

    2011-01-01

    We present constraints on the primordial power spectrum of adiabatic fluctuations using data from the 2008 Southern Survey of the Atacama Cosmology Telescope (ACT). The angular resolution of ACT provides sensitivity to scales beyond l = 1000 for resolution of multiple peaks in the primordial temperature power spectrum, which enables us to probe the primordial power spectrum of adiabatic scalar perturbations with wavenumbers up to k approx. = 0.2 Mp/c. We find no evidence for deviation from power-law fluctuations over two decades in scale. Matter fluctuations inferred from the primordial temperature power spectrum evolve over cosmic time and can be used to predict the matter power spectrum at late times; we illustrate the overlap of the matter power inferred from CMB measurements (which probe the power spectrum in thc linear regime) with existing probes of galaxy clustering, cluster abundances and weak lensing constraints on the primordial power. This highlights the range of scales probed by current measurement.s of the matter power spectrum.

  18. Proteomic Analysis of Fetal Ovaries Reveals That Primordial Follicle Formation and Transition Are Differentially Regulated.

    Science.gov (United States)

    Xu, Mengmeng; Che, Long; Yang, Zhenguo; Zhang, Pan; Shi, Jiankai; Li, Jian; Lin, Yan; Fang, Zhengfeng; Che, Lianqiang; Feng, Bin; Wu, De; Xu, Shengyu

    2017-01-01

    Primordial follicle formation represents a critical phase of the initiation of embryonic reproductive organ development, while the primordial follicle transition into primary follicle determines whether oestrus or ovulation will occur in female animals. To identify molecular mechanism of new proteins which are involved in ovarian development, we employed 2D-DIGE to compare the protein expression profiles of primordial follicles and primary follicles of fetal ovaries in pigs. Fetal ovaries were collected at distinct time-points of the gestation cycle (g55 and g90). The identified proteins at the g55 time-point are mainly involved in the development of anatomical structures [reticulocalbin-1 (RCN1), reticulocalbin-3 (RCN3)], cell differentiation (actin), and stress response [heterogeneous nuclear ribonucleoprotein K (HNRNPK)]. Meanwhile, at the g90 stage, the isolated proteins with altered expression levels were mainly associated with cell proliferation [major vault protein (MVP)] and stress response [heat shock-related 70 kDa protein 2 (HSPA2)]. In conclusion, our work revealed that primordial follicle formation is regulated by RCN1, RCN3, actin, and HNRNPK, while the primordial follicle transformation to primary follicle is regulated by MVP and HSPA2. Therefore, our results provide further information for the prospective understanding of the molecular mechanism(s) involved in the regulation of the ovarian follicle development.

  19. Cyclic AMP in oocytes controls meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary.

    Science.gov (United States)

    Wang, Yijing; Teng, Zhen; Li, Ge; Mu, Xinyi; Wang, Zhengpin; Feng, Lizhao; Niu, Wanbao; Huang, Kun; Xiang, Xi; Wang, Chao; Zhang, Hua; Xia, Guoliang

    2015-01-15

    In mammalian ovaries, a fixed population of primordial follicles forms during the perinatal stage and the oocytes contained within are arrested at the dictyate stage of meiotic prophase I. In the current study, we provide evidence that the level of cyclic AMP (cAMP) in oocytes regulates oocyte meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary. Our results show that the early meiotic development of oocytes is closely correlated with increased levels of intra-oocyte cAMP. Inhibiting cAMP synthesis in fetal ovaries delayed oocyte meiotic progression and inhibited the disassembly and degradation of synaptonemal complex protein 1. In addition, inhibiting cAMP synthesis in in vitro cultured fetal ovaries prevented primordial follicle formation. Finally, using an in situ oocyte chromosome analysis approach, we found that the dictyate arrest of oocytes is essential for primordial follicle formation under physiological conditions. Taken together, these results suggest a role for cAMP in early meiotic development and primordial follicle formation in the mouse ovary. © 2015. Published by The Company of Biologists Ltd.

  20. The Initial State of a Primordial Anisotropic Stage of Inflation

    Energy Technology Data Exchange (ETDEWEB)

    Blanco-Pillado, Jose J. [Department of Theoretical Physics, University of the Basque Country UPV/EHU,48080 Bilbao (Spain); IKERBASQUE, Basque Foundation for Science,Maria Diaz de Haro 3, 48013 Bilbao (Spain); Minamitsuji, Masato [Yukawa Institute for Theoretical Physics, Kyoto University,Kitashirakawa-Oiwakecho, Sakyo-Ku, Kyoto 606-8502 (Japan); CENTRA, Instituto Superior Tecnico, Universidade de Lisboa,Avenida Rovisco Pais 1, 1049-001 Lisboa (Portugal)

    2015-06-12

    We investigate the possibility that the inflationary period in the early universe was preceded by a primordial stage of strong anisotropy. In particular we focus on the simplest model of this kind, where the spacetime is described by a non-singular Kasner solution that quickly evolves into an isotropic de Sitter space, the so-called Kasner-de Sitter solution. The initial Big Bang singularity is replaced, in this case, by a horizon. We show that the extension of this metric to the region behind the horizon contains a timelike singularity which will be visible by cosmological observers. This makes it impossible to have a reliable prediction of the quantum state of the cosmological perturbations in the region of interest. In this paper we consider the possibility that this Kasner-de Sitter universe is obtained as a result of a quantum tunneling process effectively substituting the region behind the horizon by an anisotropic parent vacuum state, namely a 1+1 dimensional spacetime compactified over an internal flat torus, T{sub 2}, which we take it to be of the form de Sitter{sub 2}×T{sub 2} or Minkowski{sub 2}×T{sub 2}. As a first approximation to understand the effects of this anisotropic initial state, we compute the power spectrum of a massless scalar field in these backgrounds. In both cases, the spectrum converges at small scales to the isotropic scale invariant form and only present important deviations from it at the largest possible scales. We find that the decompactification scenario from M{sub 2}×T{sub 2} leads to a suppressed and slightly anisotropic power spectrum at large scales which could be related to some of the anomalies present in the current CMB data. On the other hand, the spectrum of the universe with a dS{sub 2}×T{sub 2} parent vacuum presents an enhancement in power at large scales not consistent with observations.