WorldWideScience

Sample records for putative mobile forms

  1. The intracellular mobility of NPY and a putative mitochondrial form of NPY in neuronal cells.

    Science.gov (United States)

    Kaipio, Katja; Pesonen, Ullamari

    2009-01-30

    Preproneuropeptide Y is a precursor peptide to mature neuropeptide Y (NPY), which is a universally expressed peptide in the central and peripheral nervous system. NPY is normally routed to endoplasmic reticulum and secretory vesicles in cells, which secrete NPY. In our previous studies, we found a functional Leucine7 to Proline7 (L7P) polymorphism in the signal peptide sequence of preproNPY. This polymorphism affects the secretion of NPY and causes multiple physiological effects in humans. The sequence of NPY mRNA contains two in frame kozak sequences that allow translation initiation to shift, and translation of two proteins. In addition to mature NPY(1-36) also a putative truncated NPY(17-36) with mitochondrial targeting signal is produced. The purpose of this study was to investigate the protein mobility of the putative mitochondrial fragment and the effect of the L7P polymorphism on the cellular level using GFP tagged constructs. The mobility was studied with fluorescence recovery after photobleaching technique in a neuronal cell line. We found that the mobility of the secretory vesicles with NPY(1-36) in cells with L7P genotype was increased in comparison to vesicle mobility in cells with the more abundant L7L genotype. The mobility in the cells with the putative mitochondrial construct was found to be very low. According to the results of the present study, the mitochondrial truncated peptide stays in the mitochondrion. It can be hypothesized that this could be one of the factors affecting energy balance of the membranes of the mitochondrion.

  2. A putatively novel form of spontaneous coordination in neural activity.

    Science.gov (United States)

    Hermer-Vazquez, Raymond; Hermer-Vazquez, Linda; Srinivasan, Sridhar

    2009-04-06

    We simultaneously recorded local field potentials from three sites along the olfactory-entorhinal axis in rats lightly anesthetized with isoflurane, as part of another experiment. While analyzing the initial data from that experiment with spectrograms, we discovered a potentially novel form of correlated neural activity, with near-simultaneous occurrence across the three widely separated brain sites. After validating their existence further, we named these events Synchronous Frequency Bursts (SFBs). Here we report our initial investigations into their properties and their potential functional significance. In Experiment 1, we found that SFBs have highly regular properties, consisting of brief (approximately 250 ms), high amplitude bursts of LFP energy spanning frequency ranges from the delta band (1-4 Hz) to at least the low gamma band (30-50 Hz). SFBs occurred almost simultaneously across recording sites, usually with onsets sites. While the SFBs had fairly typical, exponentially decaying power spectral density plots, their coherence structure was unusual, with high peaks in several narrow frequency ranges and little coherence in other bands. In Experiment 2, we found that SFBs occurred far more often under light anesthesia than deeper anesthetic states, and were especially prevalent as the animals regained consciousness. Finally, in Experiment 3 we showed that SFBs occur simultaneously at a significant rate across brain sites from putatively different functional subsystems--olfactory versus motor pathways. We suggest that SFBs do not carry information per se, but rather, play a role in coordinating activity in different frequency bands, potentially brain-wide, as animals progress from sleep or anesthesia toward full consciousness.

  3. Mobile based optical form evaluation system

    Directory of Open Access Journals (Sweden)

    Asım Sinan YÜKSEL

    2016-05-01

    Full Text Available Optical forms that contain multiple-choice answers are widely used both for electing students and evaluating student achievements in education systems in our country and worldwide. Optical forms are evaluated by employing optical mark recognition techniques through optical readers. High cost of these machines, limited access to them, long waiting time for evaluation results make the process hard for educationists working in cities or countries. In this study, a mobile application was developed for the educationists who own mobile phones or tablets for the purpose of evaluating students' answer sheets quickly and independent of location and optical readers. Optical form recognition, reading and evaluation processes are done on the image of student's answer sheet that is taken with the mobile phone or tablet of educationist. The Android based mobile application that we developed has a user-friendly interface, high success rate and is the first of our knowledge application that operates on mobile platforms in this field.

  4. Diarrhea-associated biofilm formed by enteroaggregative Escherichia coli and aggregative Citrobacter freundii: a consortium mediated by putative F pili

    Directory of Open Access Journals (Sweden)

    Araújo Ana CG

    2010-02-01

    Full Text Available Abstract Background Enteroaggregative Escherichia coli (EAEC are enteropathogenic strains identified by the aggregative adhesion (AA pattern that share the capability to form biofilms. Citrobacter freundii is classically considered as an indigenous intestinal species that is sporadically associated with diarrhea. Results During an epidemiologic study focusing on infantile diarrhea, aggregative C. freundii (EACF and EAEC strains were concomitantly recovered from a severe case of mucous diarrhea. Thereby, the occurrence of synergic events involving these strains was investigated. Coinfection of HeLa cells with EACF and EAEC strains showed an 8-fold increase in the overall bacterial adhesion compared with single infections (P traA were capable of forming bacterial aggregates only in the presence of EACF. Scanning electronic microscopy analyses revealed that bacterial aggregates as well as enhanced biofilms formed by EACF and traA-positive EAEC were mediated by non-bundle forming, flexible pili. Moreover, mixed biofilms formed by EACF and traA-positive EAEC strains were significantly reduced using nonlethal concentration of zinc, a specific inhibitor of F pili. In addition, EAEC strains isolated from diarrheic children frequently produced single biofilms sensitive to zinc. Conclusions Putative F pili expressed by EAEC strains boosted mixed biofilm formation when in the presence of aggregative C. freundii.

  5. Network Coding Opportunities for Wireless Grids Formed by Mobile Devices

    DEFF Research Database (Denmark)

    Nielsen, Karsten Fyhn; Madsen, Tatiana Kozlova; Fitzek, Frank

    2008-01-01

    link should be taken into account. We focus on the question how nodes can efficiently communicate and distribute data in a wireless grid. We show the potential of a network coding approach when nodes have the possibility to combine packets thus increasing the amount of information per transmission. Our......Wireless grids have potential in sharing communication, computational and storage resources making these networks more powerful, more robust, and less cost intensive. However, to enjoy the benefits of cooperative resource sharing, a number of issues should be addressed and the cost of the wireless...... implementation demonstrates the feasibility of network coding for wireless grids formed by mobile devices....

  6. Mobilization of horizontally acquired island 2 is induced in planta in the phytopathogen Pectobacterium atrosepticum SCRI1043 and involves the putative relaxase ECA0613 and quorum sensing.

    Science.gov (United States)

    Vanga, Bhanupratap R; Ramakrishnan, Pavithra; Butler, Ruth C; Toth, Ian K; Ronson, Clive W; Jacobs, Jeanne M E; Pitman, Andrew R

    2015-11-01

    Integrative and conjugative elements (ICEs) contribute to the rapid evolution of bacterial pathogens via horizontal gene transfer of virulence determinants. ICEs have common mechanisms for transmission, yet the cues triggering this process under natural environmental or physiological conditions are largely unknown. In this study, mobilization of the putative ICE horizontally acquired island 2 (HAI2), present in the chromosome of the phytopathogen Pectobacterium atrosepticum SCRI1043, was examined during infection of the host plant potato. Under these conditions, mobilization of HAI2 increased markedly compared with in vitro cultures. In planta-induced mobilization of HAI2 was regulated by quorum sensing and involved the putative ICE-encoded relaxase ECA0613. Disruption of ECA0613 also reduced transcription of genes involved in production of coronafacic acid (Cfa), the major virulence factor harboured on HAI2, whereas their expression was unaffected in the quorum-sensing (expI) mutant. Thus, suppression of cfa gene expression was not regulated by the mobilization of the ICE per se, but was due directly to inactivation of the relaxase. The identification of genetic factors associated solely with in planta mobilization of an ICE demonstrates that this process is highly adapted to the natural environment of the bacterial host and can influence the expression of virulence determinants.

  7. Measurement campaign on connectivity of mesh networks formed by mobile devices

    DEFF Research Database (Denmark)

    Pietrarca, Beatrice; Sasso, Giovanni; Perrucci, Gian Paolo

    2007-01-01

    This paper reports the results of a measurement campaign on the connectivity level of mobile devices using Bluetooth (BT) to form cooperative mobile mesh networks. Such mobile mesh networks composed of mobile devices are the basis for any peer-to-peer communication like wireless grids or social...

  8. Impeding 99Tc(IV) mobility in novel waste forms

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Mal Soon; Um, Wooyong; Wang, Guohui; Kruger, Albert A.; Lukens, Wayne W.; Rousseau, Roger J.; Glezakou, Vassiliki Alexandra

    2016-06-30

    Technetium (99Tc) is a long-lived radioactive fission product whose mobility in the subsurface is largely governed by its oxidation state1. Immobilization of Tc in mineral substrates is crucial for radioactive waste management and environmental remediation. Tc(IV) incorporation in spinels2, 3 has been proposed as a novel method to increase Tc retention in glass waste forms. However, experiments with Tc-magnetite under high temperature and oxic conditions showed re-oxidation of Tc(IV) to volatile pertechnetate Tc(VII)O4-.4, 5 Here we address this problem with large-scale ab initio molecular dynamics simulations and propose that elevated temperatures, 1st row transition metal dopants can significantly enhance Tc retention in the order Co > Zn > Ni. Experiments with doped spinels at T=700 ºC provided quantitative confirmation of increased Tc retention in the same order predicted by theory. This work highlights the power of modern state-of-the-art simulations to provide essential insights and generate bottom-up design criteria of complex oxide materials at elevated temperatures.

  9. Impeding 99Tc(IV) mobility in novel waste forms

    Science.gov (United States)

    Lee, Mal-Soon; Um, Wooyong; Wang, Guohui; Kruger, Albert A.; Lukens, Wayne W.; Rousseau, Roger; Glezakou, Vassiliki-Alexandra

    2016-06-01

    Technetium (99Tc) is an abundant, long-lived radioactive fission product whose mobility in the subsurface is largely governed by its oxidation state. Tc immobilization is crucial for radioactive waste management and environmental remediation. Tc(IV) incorporation in spinels has been proposed as a novel method to increase Tc retention in glass waste forms during vitrification. However, experiments under high-temperature and oxic conditions show reoxidation of Tc(IV) to volatile pertechnetate, Tc(VII). Here we examine this problem with ab initio molecular dynamics simulations and propose that, at elevated temperatures, doping with first row transition metal can significantly enhance Tc retention in magnetite in the order Co>Zn>Ni. Experiments with doped spinels at 700 °C provide quantitative confirmation of the theoretical predictions in the same order. This work highlights the power of modern, state-of-the-art simulations to provide essential insights and generate theory-inspired design criteria of complex materials at elevated temperatures.

  10. Synthesis and Analysis of Putative Terpene Oxidation Products and the Secondary Organic Aerosol Particles that Form from Them

    Science.gov (United States)

    Ebben, C. J.; Strick, B. F.; Upshur, M.; Shrestha, M.; Velarde, L.; Lu, Z.; Wang, H.; Xiao, D.; Batista, V. S.; Martin, S. T.; Thomson, R. J.; Geiger, F. M.

    2013-12-01

    The terpenes isoprene and α-pinene are abundant volatile organic compounds (VOCs) that are emitted by trees and oxidized in the atmosphere. However, the chemical processes involved in the formation of secondary organic aerosol (SOA) particles from VOCs are not well understood. In this work, we use a combined synthetic, analytical, and theoretical approach to gain a molecular level understanding of the chemistry involved in the formation of SOA particles from VOC precursors. To this end, we have synthesized putative products of isoprene and α-pinene oxidation and the oligomers that form from them. Specifically, we have focused on the epoxide and 2-methyltetraols that form from isoprene oxidation by hydroxyl radicals, as well as products of α-pinene ozonolysis. In our analysis, we utilize a spectroscopic technique called sum frequency generation (SFG). SFG is a coherent, surface-specific, vibrational spectroscopy that uses infrared and visible laser light fields, overlapped spatially and temporally at a surface, to probe vibrational transitions within molecules. Our use of this technique allows us to assess the chemical identity of aerosol-forming components at their surfaces, where interactions with the gas phase occur. The spectral responses from these compounds are compared to those of synthetic isoprene- and α-pinene-derived aerosol particles, as well as natural aerosol particles collected in tropical and boreal forests to begin to predict the constituents that may be present at the surfaces of these particles. In addition, isotope editing is utilized to gain a better understanding of α-pinene. The rigidity of this molecule makes it difficult to understand spectroscopically. The combination of synthesis with deuterium labeling, theory, and broadband and high-resolution SFG spectroscopy in the C-H and C-D stretching regions allow us to determine the orientation of this important molecule on a surface, which could have implications for its reactivity in the

  11. An Extended Application form of Mobile Computing──Augmented Reality

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    With the rapid developments of wireless communication and microelectronic technology, the bandwidth of wireless communication is becoming wider than ever, up to 100Gbps and the computer can be designed as small as a match with powerful computing and controlling capability. These rapid developments have extended the mobile computing. There are many application forms of mobile computing, such as mobile databases, mobile data management, wearable computing etc. A great branch of mobile computing, Augmented Reality (AR), which is the combination of mobile computing and wearable computers was discussed.

  12. Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer.

    Science.gov (United States)

    Hadi, S M; Ullah, M F; Azmi, A S; Ahmad, A; Shamim, U; Zubair, H; Khan, H Y

    2010-06-01

    Plant polyphenols are important components of human diet, and a number of them are considered to possess chemopreventive and therapeutic properties against cancer. They are recognized as naturally occurring anti-oxidants but also act as pro-oxidants catalyzing DNA degradation in the presence of metal ions such as copper. The plant polyphenol resveratrol confers resistance to plants against fungal agents and has been implicated as a cancer chemopreventive agent. Of particular interest is the observation that resveratrol has been found to induce apoptosis in cancer cell lines but not in normal cells. Over the last few years, we have shown that resveratrol is capable of causing DNA breakage in cells such as human lymphocytes. Such cellular DNA breakage is inhibited by copper specific chelators but not by iron and zinc chelating agents. Similar results are obtained by using permeabilized cells or with isolated nuclei, indicating that chromatin-bound copper is mobilized in this reaction. It is well established that tissue, cellular and serum copper levels are considerably elevated in various malignancies. Therefore, cancer cells may be more subject to electron transfer between copper ions and resveratrol to generate reactive oxygen species responsible for DNA cleavage. The results are in support of our hypothesis that anti-cancer mechanism of plant polyphenols involves mobilization of endogenous copper and the consequent pro-oxidant action. Such a mechanism better explains the anti-cancer effects of resveratrol, as it accounts for the preferential cytotoxicity towards cancer cells.

  13. Designing Mobile Interactions: The continual convergence of form and context

    DEFF Research Database (Denmark)

    Kjeldskov, Jesper

    2013-01-01

    fremmes en design-orienteret måde at opnå konvergens mellem form og kontekst gennem en kontekstuelt forankret, helhedsorienteret, og kontinuerligt udfoldende designproces. “Fantasi er vigtigere end viden. For viden er begrænset, mens fantasien favner hele verden” sagde Albert Einstein i 1931. Inden...

  14. Mobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer Mechanism

    Directory of Open Access Journals (Sweden)

    Haseeb Zubair

    2016-06-01

    Full Text Available There is compelling evidence that serum, tissue and intracellular levels of copper are elevated in all types of cancer. Copper has been suggested as an important co-factor for angiogenesis. It is also a major metal ion present inside the nucleus, bound to DNA bases, particularly guanine. We have earlier proposed that the interaction of phenolic-antioxidants with intracellular copper leads to the generation of reactive oxygen species (ROS that ultimately serve as DNA cleaving agents. To further validate our hypothesis we show here that the antioxidant gossypol and its semi-synthetic derivative apogossypolone induce copper-mediated apoptosis in breast MDA-MB-231, prostate PC3 and pancreatic BxPC-3 cancer cells, through the generation of ROS. MCF10A breast epithelial cells refractory to the cytotoxic property of these compounds become sensitized to treatment against gossypol, as well as apogossypolone, when pre-incubated with copper. Our present results confirm our earlier findings and strengthen our hypothesis that plant-derived antioxidants mobilize intracellular copper instigating ROS-mediated cellular DNA breakage. As cancer cells exist under significant oxidative stress, this increase in ROS-stress to cytotoxic levels could be a successful anticancer approach.

  15. Comparison of the PTSD Checklist (PCL) Administered via a Mobile Device Relative to a Paper Form.

    Science.gov (United States)

    Price, Matthew; Kuhn, Eric; Hoffman, Julia E; Ruzek, Josef; Acierno, Ron

    2015-10-01

    Mobile devices are increasingly used to administer self-report measures of mental health symptoms. There are significant differences, however, in the way that information is presented on mobile devices compared to the traditional paper forms that were used to administer such measures. Such differences may systematically alter responses. The present study evaluated if and how responses differed for a self-report measure, the PTSD Checklist (PCL), administered via mobile device relative to paper and pencil. Participants were 153 trauma-exposed individuals who completed counterbalanced administrations of the PCL on a mobile device and on paper. PCL total scores (d = 0.07) and item responses did not meaningfully or significantly differ across administrations. Power was sufficient to detect a difference in total score between administrations determined by prior work of 3.46 with a d = 0.23. The magnitude of differences between administration formats was unrelated to prior use of mobile devices or participant age. These findings suggest that responses to self-report measures administered via mobile device are equivalent to those obtained via paper and they can be used with experienced as well as naïve users of mobile devices. Copyright © 2015 Wiley Periodicals, Inc., A Wiley Company.

  16. Forming Professional Mobility in the Process of Future Master Philologists’ Training in Ukraine and Abroad

    Directory of Open Access Journals (Sweden)

    Semenog Olena

    2016-12-01

    Full Text Available On the basis of scientific research, the experience of higher education institutions in Ukraine and abroad (the USA, the Swiss Confederation concerning the forming of future philologists’ professional mobility in the process of Master training has been generalized. It has been overviewed, that professional mobility is an essential indicator of the professional and social maturity of a worker. It has been found out that the content of the Master training has to ensure the forming of such features of professional mobility: openness and creativity, which are expressed in susceptibility to new and rejection from stereotypes, in the creative attitude to the profession; commitment to occupy the new activities; an ability for quick adaptation to changing conditions of professional activity; communication. It has been proved, that the forming of specialists’ professional mobility in philology in the process of Master training is more productive when it is based on the ground of values and consistent with professional competence. Having analysed the experience of the aforementioned universities, state standards of competence training of Master philologists have been developed. They are oriented to innovation in professional activities. As a result of fundamental scientific training, which is undertaken during problem lectures, seminars, discussions, scientific workshops, there is a specialist with high social maturity, professional liability, with philological and pedagogical knowledge, words and style, reading culture, compression, editing, translation, building a new high-quality text, communicative culture, with the willingness to use the experience in various fields of teaching, scientific research, administrative innovation.

  17. Personal mobility and its forming at a student in the process of physical education at general school.

    Directory of Open Access Journals (Sweden)

    Artyushenko A.A.

    2011-08-01

    Full Text Available Rich in content essence of concept «Personality mobility» and its structure is considered. The model of forming at the student of general school of personality mobility is developed in the process of physical education. A model contains the constituents of personality mobility, functions, facilities, pedagogical terms. 386 student junior classes, teenagers and senior pupils, took part in a two-year forming pedagogical experiment. It is rotined that moving of student experimental classes with the low and middle levels of formed of constituents of personality mobility in groups with sufficient and high levels took place considerably more intensive, than in control classes.

  18. The concept of a walkable city as an alternative form of urban mobility

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    Katarzyna TUROŃ

    2017-06-01

    Full Text Available The article is dedicated to the concept of the walkable city as an alternative form of urban mobility. In the work, the authors present basic principles connected with the notion of walkability in the context of sustainable development and sustainable transport. The authors also discuss pro-pedestrian solutions implemented in the Polish cities of Łódź, Rybnik, Szczecin, Gdynia, Wrocław and Katowice, including examples of good practice regarding walkability and the “Walk Score” indicator. The article also introduces typical problems related to pedestrians’ movement around the city. The advantages of implementing the walkability concept and the factors related to making cities more “pedestrianfriendly” are mentioned as well. Overall, the aim of this work is to introduced the concept of walkability as an alternative form of smart mobility in the context of urban logistics.

  19. The levels of forming at students of general school operating mobility as executive component of arbitrary management of moving activity.

    Directory of Open Access Journals (Sweden)

    Artyushenko A.A.

    2011-03-01

    Full Text Available The aim of researches is to determine concept «Personality mobility» in the light of pictures of arbitrary management conduct and activity of man In the article is considered question of diagnostics of forming operating mobility for the students of general school as activity of constituent of arbitrary management. It is certain four levels of formed operating mobility for lower boys, for teenagers and for senior pupils. It is well-proven that for period of studies at general school the indexes of operating mobility of students are not change substantially.

  20. Small Form Factor Information Storage Devices for Mobile Applications in Korea

    Science.gov (United States)

    Park, Young-Pil; Park, No-Cheol; Kim, Chul-Jin

    Recently, the ubiquitous environment in which anybody can reach a lot of information data without any limitations on the place and time has become an important social issue. There are two basic requirements in the field of information storage devices which have to be satisfied; the first is the demand for the improvement of memory capacity to manage the increased data capacity in personal and official purposes. The second is the demand for new development of information storage devices small enough to be applied to mobile multimedia digital electronics, including digital camera, PDA and mobile phones. To summarize, for the sake of mobile applications, it is necessary to develop information storage devices which have simultaneously a large capacity and a small size. Korea possesses the necessary infrastructure for developing such small sized information storage devices. It has a good digital market, major digital companies, and various research institutes. Nowadays, many companies and research institutes including university cooperate together in the research on small sized information storage devices. Thus, it is expected that small form factor optical disk drives will be commercialized in the very near future in Korea.

  1. Identification of a novel variant of staphylococcal cassette chromosome mec, type II.5, and Its truncated form by insertion of putative conjugative transposon Tn6012.

    Science.gov (United States)

    Han, Xiao; Ito, Teruyo; Takeuchi, Fumihiko; Ma, Xiao Xue; Takasu, Michihiko; Uehara, Yoshio; Oliveira, Duarte C; de Lencastre, Hermínia; Hiramatsu, Keiichi

    2009-06-01

    We identified two novel staphylococcal cassette chromosome mec (SCCmec) elements in sequence type 8 methicillin-resistant Staphylococcus aureus strains isolated in Japan: type II.5 SCCmec, whose J1 region was highly homologous to that of type I.2 SCCmec of strain PL72 (previously isolated in Poland), and its J1 region variant caused by the deletion/insertion of putative conjugative transposon Tn6012, identified in four S. aureus genomes.

  2. Mobil tabanlı optik form değerlendirme sistemi

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    Asım Sinan YÜKSEL

    2016-05-01

    Full Text Available Ülkemizde ve dünyadaki eğitim sistemlerinde gerek öğrencilerin başarılarının değerlendirilmesinde gerekse öğrenci seçiminde çoktan seçmeli şıklar içeren optik formlar çok sık kullanılmaktadır. Optik formlar optik okuyucu cihazlar sayesinde optik işaret tanıma teknikleri kullanılarak değerlendirilmektedir. Bu tip cihazların pahalı olması, bu cihazlara erişimin sınırlı olması ve değerlendirme sonuçlarını bekleme süresinin uzun olması hem büyük şehirlerde hem de taşrada çalışan eğitimcilere zorluk çıkarmaktadır. Bu çalışmada eğitimcilerin sahip oldukları akıllı telefon ya da tabletleri aracılığı ile bir mekâna ya da optik cihaza bağlı kalmadan, hızlı bir şekilde öğrenci cevap formlarını değerlendirebilecekleri mobil bir yazılım geliştirilmiştir. Optik form tanıma, okuma ve değerlendirme işlemi eğitimcinin mobil telefonu ya da tableti aracılığı ile çektiği öğrencinin cevap formu görüntüsü üzerinde yapılmaktadır. Geliştirdiğimiz Android tabanlı mobil uygulama kullanıcı dostu bir arayüze sahip olup başarı oranı yüksektir ve bu alanda mobil ortamlarda çalışan ilk uygulama olma özelliğini taşımaktadır.

  3. Mobilities

    DEFF Research Database (Denmark)

    simple movements of people, goods, and information from A to B. The ‘mobilities turn’ has made it its hallmark to explore the ‘more than’ effects of a world increasingly on the move. This new title in the Routledge Series ‘Critical Concepts in Built Environment’ creates a state-of-the-art reference work......The world is on the move. This is a widespread understanding by many inhabitants of contemporary society across the Globe. But what does it actually mean? During over one decade the ‘mobilities turn’ within the social sciences have provided a new set of insights into the repercussions of mobilities...... to social networks, personal identities, and our relationship to the built environment. The omnipresence of mobilities within everyday life, high politics, technology, and tourism (to mention but a few) all point to a key insight harnessed by the ‘mobilities turn’. Namely that mobilities is much more than...

  4. Mobilization

    Science.gov (United States)

    1987-01-01

    istic and romantic emotionalism that typifies this genre. Longino, James C., et al. “A Study of World War Procurement and Industrial Mobilization...States. Harrisburg, PA: Military Service Publishing Co., 1941. CARL 355.22 J72b. Written in rough prose , this World War II era document explains the

  5. Forms and mobility of trace elements in soils of park areas from the city of Bydgoszcz, north Poland

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    Dąbkowska-Naskręt Halina

    2016-06-01

    Full Text Available Increasing human activity affects urban ecosystem, including soils. The objective of the study were examine the content of lead, cadmium, copper, zinc, and manganese in soils of city parks and green areas from Bydgoszcz agglomeration, north Poland, estimate their forms and mobility, characterize distribution within soil profile, and estimate their origin – anthropogenic or natural. Three green areas from the older part of the city were selected for the study. Multistep sequential extraction method was conducted for the separation of seven metal fractions. It is concluded that soil studied were contaminated mainly by zinc and lead. These metals exist mainly in relatively non mobile forms i.e. associated with amorphous and crystalline iron oxides and with soil organic matter. The distribution within soil depth varied due to the elution process and variation of mixed soil material and additives.

  6. The capacity of Listeria monocytogenes mutants with in-frame deletions in putative ATP-binding cassette transporters to form biofilms and comparison with the wild type

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    Marina Ceruso

    2014-02-01

    Full Text Available Listeria monocytogenes (Lm is a food-borne pathogen responsible for human listeriosis, an invasive infection with high mortality rates. Lm has developed efficient strategies for survival under stress conditions such as starvation and wide variations in temperature, pH, and osmolarity. Therefore, Lm can survive in food under multiple stress conditions. Detailed studies to determine the mode of action of this pathogen for survival under stress conditions are important to control Lm in food. It has been shown that genes encoding for ATP-binding cassette (ABC transporters are induced in Lm in food, in particular under stress conditions. Previous studies showed that these genes are involved in sensitivity to nisin, acids, and salt. The aim of this study was to determine the involvement of some ABC transporters in biofilm formation. Therefore, deletion mutants of ABC transporter genes (LMOf2365_1875 and LMOf2365_1877 were created in Lm F2365, and then were compared to the wild type for their capacity to form biofilms. Lm strain F2365 was chosen as reference since the genome is fully sequenced and furthermore this strain is particularly involved in food-borne outbreaks of listeriosis. Our results showed that DLMOf2365_1875 had an increased capacity to form biofilms compared to the wild type, indicating that LMOf2365_1875 negatively regulates biofilm formation. A deeper knowledge on the ability to form biofilms in these mutants may help in the development of intervention strategies to control Lm in food and in the environment.

  7. The Capacity of Listeria Monocytogenes Mutants with In-Frame Deletions in Putative ATP-Binding Cassette Transporters to form Biofilms and Comparison with the Wild Type

    Science.gov (United States)

    Ceruso, Marina; Fratamico, Pina; Chirollo, Claudia; Taglialatela, Rosanna; Cortesi, Maria Luisa

    2014-01-01

    Listeria monocytogenes (Lm) is a food-borne pathogen responsible for human listeriosis, an invasive infection with high mortality rates. Lm has developed efficient strategies for survival under stress conditions such as starvation and wide variations in temperature, pH, and osmolarity. Therefore, Lm can survive in food under multiple stress conditions. Detailed studies to determine the mode of action of this pathogen for survival under stress conditions are important to control Lm in food. It has been shown that genes encoding for ATP-binding cassette (ABC) transporters are induced in Lm in food, in particular under stress conditions. Previous studies showed that these genes are involved in sensitivity to nisin, acids, and salt. The aim of this study was to determine the involvement of some ABC transporters in biofilm formation. Therefore, deletion mutants of ABC transporter genes (LMOf2365_1875 and LMOf2365_1877) were created in Lm F2365, and then were compared to the wild type for their capacity to form biofilms. Lm strain F2365 was chosen as reference since the genome is fully sequenced and furthermore this strain is particularly involved in food-borne outbreaks of listeriosis. Our results showed that ΔLMOf2365_1875 had an increased capacity to form biofilms compared to the wild type, indicating that LMOf2365_1875 negatively regulates biofilm formation. A deeper knowledge on the ability to form biofilms in these mutants may help in the development of intervention strategies to control Lm in food and in the environment. PMID:27800311

  8. Closed-form inverse kinematics for intra-operative mobile C-arm positioning with six degrees of freedom

    Science.gov (United States)

    Wang, Lejing; Zou, Rui; Weidert, Simon; Landes, Juergen; Euler, Ekkehard; Burschka, Darius; Navab, Nassir

    2011-03-01

    For trauma and orthopedic surgery, maneuvering a mobile C-arm X-ray device into a desired position in order to acquire the right picture is a routine task. The precision and ease of use of the C-arm positioning becomes even more important for more advanced imaging techniques as parallax-free X-ray image stitching, for example. Standard mobile C-arms have only five degrees of freedom (DOF), which definitely restricts their motions that have six DOF in 3D Cartesian space. We have proposed a method to model the kinematics of the mobile Carm and operating table as an integrated 6DOF C-arm X-ray imaging system.1 This enables mobile C-arms to be positioned relative to the patient's table with six DOF in 3D Cartesian space. Moving mobile C-arms to a desired position and orientation requires finding the necessary joint values, which is an inverse kinematics problem. In this paper, we present closed-form solutions, i.e. analytic expressions, obtained in an algebraic way for the inverse kinematics problem of the 6DOF C-arm model. In addition, we implement a 6DOF C-arm system for interactively radiation-free C-arm positioning based on a continuous guidance from C-arm pose estimation. For this we employ a visual marker pattern attached under the operating table and a mobile C-arm system augmented by a video camera and mirror construction. In our experiment, repositioning C-arm to a pre-defined pose in a phantom study demonstrates the practicality and accuracy of our developed 6DOF C-arm system.

  9. Functional significance of the highly conserved Glu(570) in the putative pore-forming helix 3 of the Bordetella pertussis haemolysin toxin.

    Science.gov (United States)

    Kurehong, Chattip; Powthongchin, Busaba; Thamwiriyasati, Niramon; Angsuthanasombat, Chanan

    2011-05-01

    Adenylate cyclase-haemolysin toxin (CyaA) is a virulence factor secreted from the etiologic agent of whooping cough, Bordetella pertussis. Previously, the haemolysin or pore-forming domain (CyaA-PF) has been shown to cause cell lysis of sheep erythrocytes independently, and the predicted helix 3((570-593)) within the PF-hydrophobic stretch could be a pore-lining constituent. Here, a plausible involvement in haemolytic activity of polar or charged residues (Glu(570), Gln(574), Glu(581), Ser(584) and Ser(585)) lining the hydrophilic side of CyaA-PF helix 3 was investigated via single-alanine substitutions. All the 126-kDa mutant proteins over-expressed in Escherichia coli were verified for toxin acylation as the results are corresponding to the wild-type toxin. When haemolytic activity of E. coli lysates containing soluble mutant proteins was tested against sheep erythrocytes, the importance of Glu(570), which is highly conserved among the pore-forming RTX cytotoxin family, was revealed for pore formation, conceivably for a general pore-lining residue involved in ion conduction.

  10. Data on the calcium-induced mobility shift of myristoylated and non-myristoylated forms of neurocalcin delta

    Directory of Open Access Journals (Sweden)

    Jeffrey Viviano

    2016-06-01

    Full Text Available This data article presents the differences observed between the myristoylated and non-myristoylated forms of the neuronal calcium sensor protein, neurocalcin delta (NCALD. Analysis of the myristoylated and non-myristoylated versions of the protein by mass spectrometry provided difference in mass values consistent with addition of myristoyl group. In the presence of calcium, mobility retardation was observed upon electrophoresis of the protein in native gels. The retardation was dose-dependent and was exhibited by both the myristoylated and non-myristoylated forms of the protein.

  11. Evisceration caused by the explosion of mobile phone battery: A rare form of domestic accident in a child

    Directory of Open Access Journals (Sweden)

    K. Simlawo

    2016-11-01

    Full Text Available A penetrating abdominal injuries with evisceration in a child caused by an explosion of a mobile phone battery, is a rare form of accident. This is a case report on a 7 year-old boy who has been brought by his parents to the Emergency Room of the Regional Hospital Center of Lomé Commune (Togo, for penetrating abdominal injury with bowel evisceration at the left flank. The boy was playing outside the house while a mobile phone battery exploded out of a burning waste, and hit him on the left flank. The examination revealed an evisceration of about 50 cm on the left flank. He benefited from a laparotomy 8 h later with lesion repair. The post-operative was simple.

  12. Long-term preservation of early formed mantle heterogeneity by mobile lid convection: Importance of grainsize evolution

    Science.gov (United States)

    Foley, Bradford J.; Rizo, Hanika

    2017-10-01

    The style of tectonics on the Hadean and Archean Earth, particularly whether plate tectonics was in operation or not, is debated. One important, albeit indirect, constraint on early Earth tectonics comes from observations of early-formed geochemical heterogeneities: 142Nd and 182W anomalies recorded in Hadean to Phanerozoic rocks from different localities indicate that chemically heterogeneous reservoirs, formed during the first ∼500 Myrs of Earth's history, survived their remixing into the mantle for over 1 Gyrs. Such a long mixing time is difficult to explain because hotter mantle temperatures, expected for the early Earth, act to lower mantle viscosity and increase convective vigor. Previous studies found that mobile lid convection typically erases heterogeneity within ∼100 Myrs under such conditions, leading to the hypothesis that stagnant lid convection on the early Earth was responsible for the observed long mixing times. However, using two-dimensional Cartesian convection models that include grainsize evolution, we find that mobile lid convection can preserve heterogeneity at high mantle temperature conditions for much longer than previously thought, because higher mantle temperatures lead to larger grainsizes in the lithosphere. These larger grainsizes result in stronger plate boundaries that act to slow down surface and interior convective motions, in competition with the direct effect temperature has on mantle viscosity. Our models indicate that mobile lid convection can preserve heterogeneity for ≈0.4-1 Gyrs at early Earth mantle temperatures when the initial heterogeneity has the same viscosity as the background mantle, and ≈1-4 Gyrs when the heterogeneity is ten times more viscous than the background mantle. Thus, stagnant lid convection is not required to explain long-term survival of early formed geochemical heterogeneities, though these heterogeneities having an elevated viscosity compared to the surrounding mantle may be essential for their

  13. Ion Mobility-Mass Spectrometry Differentiates Protein Quaternary Structures Formed in Solution and in Electrospray Droplets.

    Science.gov (United States)

    Han, Linjie; Ruotolo, Brandon T

    2015-07-01

    Electrospray ionization coupled to mass spectrometry is a key technology for determining the stoichiometries of multiprotein complexes. Despite highly accurate results for many assemblies, challenging samples can generate signals for artifact protein-protein binding born of the crowding forces present within drying electrospray droplets. Here, for the first time, we study the formation of preferred protein quaternary structures within such rapidly evaporating nanodroplets. We use ion mobility and tandem mass spectrometry to investigate glutamate dehydrogenase dodecamers and serum amyloid P decamers as a function of protein concentration, along with control experiments using carefully chosen protein analogues, to both establish the formation of operative mechanisms and assign the bimodal conformer populations observed. Further, we identify an unprecedented symmetric collision-induced dissociation pathway that we link directly to the quaternary structures of the precursor ions selected.

  14. Mobile health IT: The effect of user interface and form factor on doctor-patient communication

    DEFF Research Database (Denmark)

    Alsos, Ole Andreas; Das, Anita; Svanæs, Dag

    2012-01-01

    -establishment of eye contact, better verbal and non-verbal contact, more gesturing, good visibility of actions, and quick information retrieval. The digital information devices lacked many of these affordances; physicians’ actions were not visible for the patients, the user interfaces required much attention...... support or hinder aspects of doctor–patient communication, such as face-to-face dialogue, nonverbal communication, and action transparency. Method The study draws on two different experimental simulation studies where 22 doctors, in 80 simulated ward rounds, accessed patient-related information from...... that physicians can use the devices to support face-to-face dialogue, nonverbal communication, and action visibility. The ability to facilitate and support the doctor–patient collaboration is a noteworthy usability factor in the design of mobile EPR systems. The paper also presents possible design guidelines...

  15. Wing Chun’s Chum Kiu Form. A Study in Stability and Mobility

    Directory of Open Access Journals (Sweden)

    Joyotpaul Chaudhuri

    2012-07-01

    Full Text Available This article analyzes the keys to motion in the second empty-hand form of Wing Chun gongfu: Chum Kiu. The focus is on the proper maintenance of the body’s central axis and its motions, which helps with the development of Wing Chun power and the foundations of delivering that power. The form includes short bridges, stepping, turning, and kicking. The motions are built on the structural foundations created by regular practice of the first form, Siu Lim Tau.

  16. Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of small molecule tyrosine kinase inhibitors and cytotoxic drugs

    Science.gov (United States)

    Puvanenthiran, Soozana; Essapen, Sharadah; Seddon, Alan M.; Modjtahedi, Helmout

    2016-01-01

    Increased expression and activation of human epidermal growth factor receptor (EGFR) and HER-2 have been reported in numerous cancers. The aim of this study was to determine the sensitivity of a large panel of human ovarian cancer cell lines (OCCLs) to treatment with various forms of small molecule tyrosine kinase inhibitors (TKIs) and cytotoxic drugs. The aim was to see if there was any association between the protein expression of various biomarkers including three putative ovarian cancer stem cell (CSC) markers (CD24, CD44, CD117/c-Kit), P-glycoprotein (P-gp), and HER family members and response to treatment with these agents. The sensitivity of 10 ovarian tumour cell lines to the treatment with various forms of HER TKIs (gefitinib, erlotinib, lapatinib, sapitinib, afatinib, canertinib, neratinib), as well as other TKIs (dasatinib, imatinib, NVP-AEW541, crizotinib) and cytotoxic agents (paclitaxel, cisplatin and doxorubicin), as single agents or in combination, was determined by SRB assay. The effect on these agents on the cell cycle distribution, and downstream signaling molecules and tumour migration were determined using flow cytometry, western blotting, and the IncuCyte Clear View cell migration assay respectively. Of the HER inhibitors, the irreversible pan-TKIs (canertinib, neratinib and afatinib) were the most effective TKIs for inhibiting the growth of all ovarian cancer cells, and for blocking the phosphorylation of EGFR, HER-2, AKT and MAPK in SKOV3 cells. Interestingly, while the majority of cancer cells were highly sensitive to treatment with dasatinib, they were relatively resistant to treatment with imatinib (i.e., IC50 >10 μM). Of the cytotoxic agents, paclitaxel was the most effective for inhibiting the growth of OCCLs, and of various combinations of these drugs, only treatment with a combination of NVP-AEW541 and paclitaxel produced a synergistic or additive anti-proliferative effect in all three cell lines examined (i.e., SKOV3, Caov3, ES2

  17. Analyzing the mobility in granular forms of P fertilizer in Brazilians soils under laboratory conditions

    Energy Technology Data Exchange (ETDEWEB)

    Castro, Robson C. de; Oliveira, Davi Ferreira de; Oliveira, Luis Fernando de; Anjos, Marcelino Jose dos, E-mail: prof.robinho@gmail.com [Universidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ (Brazil). Inst. de Fisica Armando Dias Tavares; Teixeira, Paulo Cesar; Benites, Vinicius Melo, E-mail: paulo.c.teixeira@embrapa.br [Embrapa Solos, Rio de Janeiro, RJ (Brazil)

    2013-07-01

    Phosphorus is an essential nutrient for plant growth. Million of tones of P are applied to the soils annually. However, only a small fraction of the P applied with fertilizers is taken up by crops in the year of application, and the effectiveness of any residual P fertilizer declines with time. To improve our understanding of the mechanisms underlying this response to P in the field, we have studied the mobility of P from 3 different fertilizes: monoammonium phosphate (MAP), polymer coated monoammonium phosphate (MAPp) and Organomineral phosphate (OMP) applied on high weathered soil samples in a Petri dish experiment. Total Reflection X-Ray Fluorescence (TXRF) was used to determine the P diffusive flux at different distances (0 - 7.5, 7.5 – 13.5, 13.5 – 25.5 and 25.5 – 43 mm) from granular fertilizer. TXRF analyses were performed at the X-Ray Fluorescence Beamline D09B at Brazilian National Synchrotron Light Laboratory (LNLS), in Campinas, Sao Paulo, using a polychromatic beam with maximum energy of 20 keV for the excitation and an Ultra-LEGe detector with resolution of 148 eV at 5.9 keV. Besides that, the detections were performed in a high vacuum chamber (2.5 x 10-5 mbar) to avoid air absorption. After a period of five weeks, the total P concentration increased in the soil sampled 7.5 to 13.5 mm from the fertilizer showing a diffusive flux of P. About 20% (considering MAP and MAPp) of the total P applied diffused out of the central soil ring. Different sources showed differences in diffusive flux of P. Soil pH also influenced diffusive flux of P showing higher flux on lower pH soils. (author)

  18. Determination of mobile form contents of Zn, Cd, Pb and Cu in soil extracts by combined stripping voltammetry

    Energy Technology Data Exchange (ETDEWEB)

    Nedeltcheva, T. [Department of Analytical Chemistry, University of Chemical Technology and Metallurgy, 8 Kl. Ohridsi Blvd., 1756 Sofia (Bulgaria)]. E-mail: nedel@uctm.edu; Atanassova, M. [Department of Analytical Chemistry, University of Chemical Technology and Metallurgy, 8 Kl. Ohridsi Blvd., 1756 Sofia (Bulgaria); Dimitrov, J. [N. Pushkarov Institute of Soil Science and Agroecology, 7 Shosse Bankya St., 1080 Sofia (Bulgaria); Stanislavova, L. [N. Pushkarov Institute of Soil Science and Agroecology, 7 Shosse Bankya St., 1080 Sofia (Bulgaria)

    2005-01-10

    The amount of mobile forms of Zn, Pb, Cd and Cu in extracts obtained by treating soil samples with ammonium nitrate were determined by an appropriate combination of anodic and cathodic stripping voltammetry with hanging mercury drop electrode. Every analysis required three mercury drops: on the first one, zinc was determined; on the second, cadmium and lead; on the third, copper was determined. Zinc, lead and cadmium were determined by conventional differential-pulse anodic stripping voltammetry. For copper determination, adsorptive differential-pulse cathodic stripping voltammetry with amalgamation using chloride ions as a complexing agent was applied. The standard deviation of the results was from 1 to 10% depending on the metal content in the sample. Voltammetric results were in good agreement with the AAS analysis. No microwave digestion of soil extracts was necessary.

  19. Effects of Application of Biogas Slurry on the Form and Mobility of Soil Phosphorus in Vegetable Greenhouse Field

    Directory of Open Access Journals (Sweden)

    WANG Min-feng

    2017-06-01

    Full Text Available A packed soil column experiment was conducted to investigate the effects of biogas slurry on phosphorus(P form and mobility in a vegetable greenhouse soil with different P fertility levels. The results showed that application of biogas slurry all significantly reduced leachate volume and total phosphorus leaching in the experimental soil with different fertility levels. Compared with control treatments, the application of biogas slurry decreased total phosphorus content in leachate by 722.3 μg·column-1 through reducing leachate volume. Total inorganic phosphorus(TIP decreased by 507.2 μg·column-1 and 1 319 μg·column-1 in the moderate-P-fertility and high-P-fertility soil, respectively. Dissolved inorganic phosphorus(DIP was decreased by 158.1 μg·column-1 and 474.3 μg·column-1 in the low-P-fertility and moderate-P-fertility soil, respectively. In low-P-fertility soil, biogas slurry application significantly increased soil total P, Olsen-P and organic P in 0~7 cm soil depth by a proportion of 34.8%, 37.7% and 148%, respectively. It also reduced soil pH by 0.39 units. In 7~14 cm soil depth, biogas slurry application significantly increased soil total P, Olsen-P and organic P by a proportion of 18.5%, 29.3% and 32.9%, respectively. SoipH was also decreased by 0.28 units. In moderate-P-fertility soil, application of biogas slurry had no significantly influence on soil total P, but increased soil Olsen-P by 20.1% in 0~7 cm soil depth compared with control treatment. In 7~14 cm soil depth, application of biogas slurry reduced soil pH by 0.33 units. In high-P-fertility soil, application of biogas slurry had no significantly influence on soil total P, Olsen-P and organic P in 0~7 cm soil depth compared with control treatment. In 7~14 cm soil depth, application of biogas slurry reduced soil pH by 0.34 units. In conclusion, application of biogas slurry significantly increased different forms of phosphorus contents in low-P-fertility soil, however

  20. Mobilities Mobilities

    Directory of Open Access Journals (Sweden)

    César Pompeyo

    2011-12-01

    Full Text Available Urry, John (2007 Mobilities.Oxford: Polity Press.Urry, John (2007 Mobilities.Oxford: Polity Press.John Urry (1946-, profesor en la Universidad de Lancaster, es un sociólogo de sobra conocido y altamente reputado en el panorama internacional de las ciencias sociales. Su dilatada carrera, aparentemente dispersa y diversificada, ha seguido senderos bastante bien definidos dejando tras de sí un catálogo extenso de obras sociológicas de primer nivel. Sus primeros trabajos se centraban en el campo de la teoría social y la filosofía de las ciencias sociales o de la sociología del poder [...

  1. Circular job-related spatial mobility in Germany:Comparative analyses of two representative surveys on the forms, prevalence and relevance in the context of partnership and family development

    Directory of Open Access Journals (Sweden)

    Heiko Rüger

    2012-01-01

    In this regard, the present article aims at achieving three essential objectives. First, we will introduce a common indicator for circular job mobility patterns found in the two surveys. On the basis of this common indicator, we will comparatively analyse the prevalence of different mobility forms and their composition according to key socio-demographic characteristics. In addition, we will use multivariate analyses to illustrate the relevance of job mobility for partnership and family development. Results suggest mobility patterns to be an important individual context factor when explaining processes relevant to partnerships and family. In particular, women who exhibit some degree of job mobility are less often married and rarely have children.

  2. Final report - Reduction of mercury in saturated subsurface sediments and its potential to mobilize mercury in its elemental form

    Energy Technology Data Exchange (ETDEWEB)

    Bakray, Tamar [Rutgers University

    2013-06-13

    The goal of our project was to investigate Hg(II) reduction in the deep subsurface. We focused on microbial and abiotic pathways of reduction and explored how it affected the toxicity and mobility of Hg in this unique environment. The project’s tasks included: 1. Examining the role of mer activities in the reduction of Hg(II) in denitrifying enrichment cultures; 2. Investigating the biotic/abiotic reduction of Hg(II) under iron reducing conditions; 3. Examining Hg(II) redox transformations under anaerobic conditions in subsurface sediments from DOE sites.

  3. A novel mutation in the putative DNA helicase XH2 is responsible for male-to-female sex reversal associated with an atypical form of the ATR-X syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Ion, A.; Telvi, L.; Galacteros, F.; McElreavey, K. [Institut Pasteur, Paris (France)] [and others

    1996-06-01

    We describe a pedigree presenting X-linked severe mental retardation associated with multiple congenital abnormalities and 46,XY gonadal dysgenesis, leading in one family member to female gender assignment. Female carriers are unaffected. The dysmorphic features are similar to those described in the {alpha}-thalassemia and mental retardation (ATR-X) syndrome, although there is no clinical evidence of {alpha}-thalassemia in this family. In addition, the family had other clinical features not previously observed in the ATR-X syndrome, including partial optic-nerve atrophy and partial ocular albinism. Mutations in a putative DNA helicase, termed XH2, have been reported to give rise to the ATR-X syndrome. We screened the YCH2 gene for mutations in affected members of the family and identified a 4-bp deletion at an intron/exon boundary that removes an invariant 3{prime} splice-acceptor site. The mutation cosegregates with the syndrome. The genomic deletion causes missplicing of the pre-mRNA, which results in the loss of 8 bp of coding sequence, thereby generating a frameshift and a downstream premature stop codon. Our finding increases the range of clinical features associated with mutations in the XH2 gene. 17 refs., 4 figs., 2 tabs.

  4. Carbon Metabolism, Uptake Kinetics, and Export: how Watershed Form Influences Carbon Mobilization and In-Stream Transformations in Headwater Catchments

    Science.gov (United States)

    Seybold, E. C.; McGlynn, B. L.

    2014-12-01

    Previous research has demonstrated the highly dynamic nature of hydrologic connectivity, and the vertical and spatial expansion of the active watershed area during wet periods. While activation of variable DOM and solute sources during expansion and contraction periods has been well documented in a number of systems, changes in nutrient loading to streams have rarely been linked explicitly to in-stream function. To this end, we investigated the linkages between terrestrial mobilization of DOC and DIC, in-stream biogeochemical cycling, and downstream transport across scales in two geomorphically contrasting watersheds located in Tenderfoot Creek Experimental Forest, Montana. We deployed a network of in-situ high frequency sensors with a focus on CO2, dissolved oxygen, fluorescent DOM, nitrate, and a suite of supporting chemical constituents every 30 minutes beginning with the onset of snowmelt and through summer baseflow recession. Our results suggest that DOM and DIC fluxes, as well as ecosystem processes such as metabolism, were coupled to watershed scale carbon accumulation and mobilization. In both watersheds, metabolism tracked the temporal trends of DOM loading from the terrestrial landscape, indicating that the streams are actively transforming allochthonous organic materials during transport. Headwater stream reaches in the watershed with more hydrologically connected riparian source areas exhibited elevated metabolism, carbon uptake, and carbon export as compared to streams in the watershed with less riparian connectivity, suggesting that the degree of riparian connectivity may explain spatial variation in metabolism and in-stream carbon cycling within and across stream networks. Ultimately, this study highlights the tight coupling between terrestrial uplands and in-stream ecosystem processes in headwater catchments, and identifies spatio-temporal variation in hydrologic connectivity as a key driver of in-stream metabolic variation. We posit that the

  5. The Tobacco etch virus P3 protein forms mobile inclusions via the early secretory pathway and traffics along actin microfilaments.

    Science.gov (United States)

    Cui, Xiaoyan; Wei, Taiyun; Chowda-Reddy, R V; Sun, Guangyu; Wang, Aiming

    2010-02-05

    Plant potyviruses encode two membrane proteins, 6K and P3. The 6K protein has been shown to induce virus replication vesicles. However, the function of P3 remains unclear. In this study, subcellular localization of the Tobacco etch virus (TEV) P3 protein was investigated in Nicotiana benthamiana leaf cells. The TEV P3 protein localized on the endoplasmic reticulum (ER) membrane and formed punctate inclusions in association with the Golgi apparatus. The trafficking of P3 to the Golgi was mediated by the early secretory pathway. The Golgi-associated punctate structures originated from the ER exit site (ERES). Deletion analyses identified P3 domains required for the retention of P3 at the Golgi. Moreover, the P3 punctate structure was found to traffic along the actin filaments and colocalize with the 6K-containing replication vesicles. Taken together, these data support previous suggestions that P3 may play dual roles in virus movement and replication.

  6. Restricted Mobilities

    DEFF Research Database (Denmark)

    Nielsen, Mette; Lassen, Claus

    2012-01-01

    communities and shopping centres through mobility lenses. The article shows how different mobility systems enable and restrict the public access to private-public spaces, and it points out that proprietary communities create an unequal potential for human movement and access in the city. The main argument......Privatisation of public spaces in the contemporary city has increased during the last decades but only few studies have approached this field from a mobility perspective. Therefore the article seeks to rectify this by exploring two Australian examples of private spaces in the city; gated...... in the article is that the many mobility systems enable specialization of places that are targeted at a special section of the population. This means that various forms of motilities not only create new opportunities for urban life but it is also one of the most critical components of production of new exclusion...

  7. Iridium oxides based gate interface of AlGaN/GaN high electron mobility transistors formed by high temperature oxidation

    Energy Technology Data Exchange (ETDEWEB)

    Lalinský, T. [Institute of Electrical Engineering of the Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava (Slovakia); Vallo, M., E-mail: martin.vallo@savba.sk [Institute of Electrical Engineering of the Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava (Slovakia); Vanko, G.; Dobročka, E. [Institute of Electrical Engineering of the Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava (Slovakia); Vincze, A. [International Laser Centre, Ilkovičova 3, 841 04 Bratislava (Slovakia); Osvald, J.; Rýger, I.; Dzuba, J. [Institute of Electrical Engineering of the Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava (Slovakia)

    2013-10-15

    We report on a high temperature forming of iridium oxides (IrO{sub 2}) gates of circular AlGaN/GaN high electron mobility transistors (C-HEMTs) to be predetermined for high temperature applications. IrO{sub 2} gate interfacial layer is formed by high temperature oxidation (T = 500–800 °C, for 1 min) of 15 nm thick Ir gate contact layer. A comprehensive microstructural and electrical characterization of the IrO{sub 2} gates is carried out to explain the improved transport properties and thermal stability of the gate interfaces. It is found that the transformation of Ir gate layer into its crystalline IrO{sub 2} phase at oxidation temperatures of 700 °C and 800 °C provides the high barrier gate interface with prevailing thermionic emission transport mechanism. Accelerated reliability tests are used to confirm C-HEMT thermally stable performance deduced from both the gate interface and 2DEG channel stability. The introduced AlGaN/GaN C-HEMTs with high temperature grown IrO{sub 2} gates seem to be very attractive for both the high temperature operated electronic and sensor devices.

  8. Staging Mobilities / Designing Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    2015-01-01

    In recent years, urban research has taken a ‘mobilities turn’. There has been a developing realisation that mobilities do not ‘just happen.’ Mobilities are carefully and meticulously designed, planned and staged (from above). However, they are equally importantly acted out, performed and lived...... as people are ‘staging themselves’ (from below). Staging mobilities is a dynamic process between ‘being staged’ (for example, being stopped at traffic lights) and the ‘mobile staging’ of interacting individuals (negotiating a passage on the pavement). Staging mobilities is about the fact that mobility...... asks: what are the physical, social, technical, and cultural conditions to the staging of contemporary urban mobilities? The theoretical framing in the Staging mobilities book is applied to four in-depth cases in the accompanying volume Designing mobilities.This book explore how places, sites...

  9. Arsenic and other oxyanion-forming trace elements in an alluvial basin aquifer: Evaluating sources and mobilization by isotopic tracers (Sr, B, S, O, H, Ra)

    Energy Technology Data Exchange (ETDEWEB)

    Vinson, David S., E-mail: dsv3@duke.edu [Duke University, Division of Earth and Ocean Sciences, Box 90227, Durham, NC 27708 (United States); McIntosh, Jennifer C. [University of Arizona, Department of Hydrology and Water Resources, 1133 E. James E. Rogers Way, Tucson, AZ 85721 (United States); Dwyer, Gary S.; Vengosh, Avner [Duke University, Division of Earth and Ocean Sciences, Box 90227, Durham, NC 27708 (United States)

    2011-08-15

    Highlights: > Elevated natural As and F occur in the Willcox Basin aquifer of Arizona. > Oxyanion-forming elements are derived from volcanic-source aquifer sediments. > Sr isotopes trace sediment sources linked to oxyanion-forming trace elements. > {sup 87}Sr/{sup 86}Sr > 0.720 indicates Proterozoic crystalline-source sediment contributing low As. > Both sediment source and hydrogeochemical evolution (Ca/Na) affect As levels. - Abstract: The Willcox Basin is a hydrologically closed basin in semi-arid southeastern Arizona (USA) and, like many other alluvial basins in the southwestern USA, is characterized by oxic, near-neutral to slightly basic groundwater containing naturally elevated levels of oxyanion-forming trace elements such as As. This study evaluates the sources and mobilization of these oxyanionic trace elements of health significance by using several isotopic tracers of water-rock interaction and groundwater sources ({sup 87}Sr/{sup 86}Sr, {delta}{sup 34}S{sub SO4}, {delta}{sup 11}B, {delta}{sup 2}H, {delta}{sup 18}O, {sup 3}H). Values of {delta}{sup 2}H (-85 per mille to -64 per mille) and {delta}{sup 18}O (-11.8 per mille to -8.6 per mille) are consistent with precipitation and groundwater in adjacent alluvial basins, and low to non-detectable {sup 3}H activities further imply that modern recharge is slow in this semi-arid environment. Large variations in {sup 87}Sr/{sup 86}Sr ratios imply that groundwater has interacted with multiple sediment sources that constitute the basin-fill aquifer, including Tertiary felsic volcanic rocks, Paleozoic sedimentary rocks, and Proterozoic crystalline rocks. In general, low concentrations of oxyanion-forming trace elements and F{sup -} are associated with a group of waters exhibiting highly radiogenic values of {sup 87}Sr/{sup 86}Sr (0.72064-0.73336) consistent with waters in Proterozoic crystalline rocks in the mountain blocks (0.73247-0.75010). Generally higher As concentrations (2-29 {mu}g L{sup -1}), other

  10. Mobile healthcare.

    Science.gov (United States)

    Morgan, Stephen A; Agee, Nancy Howell

    2012-01-01

    Mobile technology's presence in healthcare has exploded over the past five years. The increased use of mobile devices by all segments of the US population has driven healthcare systems, providers, and payers to accept this new form of communication and to develop strategies to implement and leverage the use of mobile healthcare (mHealth) within their organizations and practices. As healthcare systems move toward a more value-driven model of care, patient centeredness and engagement are the keys to success. Mobile healthcare will provide the medium to allow patients to participate more in their care. Financially, mHealth brings to providers the ability to improve efficiency and deliver savings to both them and the healthcare consumer. However, mHealth is not without challenges. Healthcare IT departments have been reluctant to embrace this shift in technology without fully addressing security and privacy concerns. Providers have been hesitant to adopt mHealth as a form of communication with patients because it breaks with traditional models. Our healthcare system has just started the journey toward the development of mHealth. We offer an overview of the mobile healthcare environment and our approach to solving the challenges it brings to healthcare organizations.

  11. Origin of fine oscillations in the photoluminescence spectrum of 2-dimensional electron gas formed in AlGaN/GaN high electron mobility transistor structures

    Energy Technology Data Exchange (ETDEWEB)

    Jana, Dipankar, E-mail: dip2602@gmail.com; Porwal, S.; Oak, S. M.; Sharma, T. K., E-mail: tarun@rrcat.gov.in [Semiconductor Physics and Devices Laboratory, Raja Ramanna Centre for Advanced Technology, Indore 452013, Madhya Pradesh (India); Jain, Anubha [Solid State Physics Laboratory, Lucknow Road, New Delhi 110054 (India)

    2015-10-28

    An unambiguous identification of the fine oscillations observed in the low temperature photoluminescence (PL) spectra of AlGaN/GaN based high electron mobility transistor (HEMT) structures is carried out. In literature, such oscillations have been erroneously identified as the sub-levels of 2-dimensional electron gas (2DEG) formed at AlGaN/GaN heterointerface. Here, the origin of these oscillations is probed by performing the angle dependent PL and reflectivity measurements under identical conditions. Contrary to the reports available in literature, we find that the fine oscillations are not related to 2DEG sub-levels. The optical characteristics of these oscillations are mainly governed by an interference phenomenon. In particular, peculiar temperature dependent redshift and excitation intensity dependent blueshift, which have been interpreted as the characteristics of 2DEG sub-levels in HEMT structures by other researchers, are understood by invoking the wavelength and temperature dependence of the refractive index of GaN within the framework of interference phenomenon. The results of other researchers are also consistently explained by considering the fine oscillatory features as the interference oscillations.

  12. Sequencing of IncX-plasmids suggests ubiquity of mobile forms of a biofilm-promoting gene cassette recruited from Klebsiella pneumoniae.

    Directory of Open Access Journals (Sweden)

    Mette Burmølle

    Full Text Available Plasmids are a highly effective means with which genetic traits that influence human health, such as virulence and antibiotic resistance, are disseminated through bacterial populations. The IncX-family is a hitherto sparsely populated group of plasmids that are able to thrive within Enterobacteriaceae. In this study, a replicon-centric screening method was used to locate strains from wastewater sludge containing plasmids belonging to the IncX-family. A transposon aided plasmid capture method was then employed to transport IncX-plasmids from their original hosts (and co-hosted plasmids into a laboratory strain (Escherichia coli Genehogs® for further study. The nucleotide sequences of the three newly isolated IncX-plasmids (pLN126_33, pMO17_54, pMO440_54 and the hitherto un-sequenced type-plasmid R485 revealed a remarkable occurrence of whole or partial gene cassettes that promote biofilm-formation in Klebsiella pneumonia or E. coli, in all four instances. Two of the plasmids (R485 and pLN126_33 were shown to directly induce biofilm formation in a crystal violet retention assay in E. coli. Sequence comparison revealed that all plasmid-borne forms of the type 3 fimbriae encoding gene cassette mrkABCDF were variations of a composite transposon Tn6011 first described in the E. coli IncX plasmid pOLA52. In conclusion, IncX-plasmids isolated from Enterobacteriaceae over almost 40 years and on three different continents have all been shown to carry a type 3 fimbriae gene cassette mrkABCDF stemming from pathogenic K. pneumoniae. Apart from contributing general knowledge about IncX-plasmids, this study also suggests an apparent ubiquity of a mobile form of an important virulence factor and is an illuminating example of the recruitment, evolution and dissemination of genetic traits through plasmid-mediated horizontal gene transfer.

  13. Sequencing of IncX-plasmids suggests ubiquity of mobile forms of a biofilm-promoting gene cassette recruited from Klebsiella pneumoniae.

    Science.gov (United States)

    Burmølle, Mette; Norman, Anders; Sørensen, Søren J; Hansen, Lars Hestbjerg

    2012-01-01

    Plasmids are a highly effective means with which genetic traits that influence human health, such as virulence and antibiotic resistance, are disseminated through bacterial populations. The IncX-family is a hitherto sparsely populated group of plasmids that are able to thrive within Enterobacteriaceae. In this study, a replicon-centric screening method was used to locate strains from wastewater sludge containing plasmids belonging to the IncX-family. A transposon aided plasmid capture method was then employed to transport IncX-plasmids from their original hosts (and co-hosted plasmids) into a laboratory strain (Escherichia coli Genehogs®) for further study. The nucleotide sequences of the three newly isolated IncX-plasmids (pLN126_33, pMO17_54, pMO440_54) and the hitherto un-sequenced type-plasmid R485 revealed a remarkable occurrence of whole or partial gene cassettes that promote biofilm-formation in Klebsiella pneumonia or E. coli, in all four instances. Two of the plasmids (R485 and pLN126_33) were shown to directly induce biofilm formation in a crystal violet retention assay in E. coli. Sequence comparison revealed that all plasmid-borne forms of the type 3 fimbriae encoding gene cassette mrkABCDF were variations of a composite transposon Tn6011 first described in the E. coli IncX plasmid pOLA52. In conclusion, IncX-plasmids isolated from Enterobacteriaceae over almost 40 years and on three different continents have all been shown to carry a type 3 fimbriae gene cassette mrkABCDF stemming from pathogenic K. pneumoniae. Apart from contributing general knowledge about IncX-plasmids, this study also suggests an apparent ubiquity of a mobile form of an important virulence factor and is an illuminating example of the recruitment, evolution and dissemination of genetic traits through plasmid-mediated horizontal gene transfer.

  14. Mobile marketing for mobile games

    OpenAIRE

    Vu, Giang

    2016-01-01

    Highly developed mobile technology and devices enable the rise of mobile game industry and mobile marketing. Hence mobile marketing for mobile game is an essential key for a mobile game success. Even though there are many articles on marketing for mobile games, there is a need of highly understanding mobile marketing strategies, how to launch a mobile campaign for a mobile game. Besides that, it is essential to understand the relationship between mobile advertising and users behaviours. There...

  15. Putative bronchopulmonary flagellated protozoa in immunosuppressed patients.

    Science.gov (United States)

    Kilimcioglu, Ali Ahmet; Havlucu, Yavuz; Girginkardesler, Nogay; Celik, Pınar; Yereli, Kor; Özbilgin, Ahmet

    2014-01-01

    Flagellated protozoa that cause bronchopulmonary symptoms in humans are commonly neglected. These protozoal forms which were presumed to be "flagellated protozoa" have been previously identified in immunosuppressed patients in a number of studies, but have not been certainly classified so far. Since no human cases of bronchopulmonary flagellated protozoa were reported from Turkey, we aimed to investigate these putative protozoa in immunosuppressed patients who are particularly at risk of infectious diseases. Bronchoalveolar lavage fluid samples of 110 immunosuppressed adult patients who were admitted to the Department of Chest Diseases, Hafsa Sultan Hospital of Celal Bayar University, Manisa, Turkey, were examined in terms of parasites by light microscopy. Flagellated protozoal forms were detected in nine (8.2%) of 110 cases. Metronidazole (500 mg b.i.d. for 30 days) was given to all positive cases and a second bronchoscopy was performed at the end of the treatment, which revealed no parasites. In conclusion, immunosuppressed patients with bronchopulmonary symptoms should attentively be examined with regard to flagellated protozoa which can easily be misidentified as epithelial cells.

  16. N-MOSFETs Formed on Solid Phase Epitaxially Grown GeSn Film with Passivation by Oxygen Plasma Featuring High Mobility.

    Science.gov (United States)

    Fang, Yung-Chin; Chen, Kuen-Yi; Hsieh, Ching-Heng; Su, Chang-Chia; Wu, Yung-Hsien

    2015-12-09

    Solid phase epitaxially grown GeSn was employed as the platform to assess the eligibility of direct O2 plasma treatment on GeSn surface for passivation of GeSn N-MOSFETs. It has been confirmed that O2 plasma treatment forms a GeSnO(x) film on the surface and the GeSnO(x) topped by in situ Al2O3 constitutes the gate stack of GeSn MOS devices. The capability of the surface passivation was evidenced by the low interface trap density (D(it)) of 1.62 × 10(11) cm(-2) eV(-1), which is primarily due to the formation of Ge-O and Sn-O bonds at the surface by high density/reactivity oxygen radicals that effectively suppress dangling bonds and decrease gap states. The good D(it) not only makes tiny frequency dispersion in the characterization of GeSn MOS capacitors, but results in GeSn N-MOSFETs with outstanding peak electron mobility as high as 518 cm(2)/(V s) which outperforms other devices reported in the literature due to reduced undesirable carrier scattering. In addition, the GeSn N-MOSFETs also exhibit promising characteristics in terms of acceptable subthreshold swing of 156 mV/dec and relatively large I(ON)/I(OFF) ratio more than 4 orders. Moreover, the robust reliability in terms small V(t) variation against high field stress attests the feasibility of using the O2 plasma-treated passivation to advanced GeSn technology.

  17. Ion mobility sensor system

    Science.gov (United States)

    Xu, Jun; Watson, David B.; Whitten, William B.

    2013-01-22

    An ion mobility sensor system including an ion mobility spectrometer and a differential mobility spectrometer coupled to the ion mobility spectrometer. The ion mobility spectrometer has a first chamber having first end and a second end extending along a first direction, and a first electrode system that generates a constant electric field parallel to the first direction. The differential mobility spectrometer includes a second chamber having a third end and a fourth end configured such that a fluid may flow in a second direction from the third end to the fourth end, and a second electrode system that generates an asymmetric electric field within an interior of the second chamber. Additionally, the ion mobility spectrometer and the differential mobility spectrometer form an interface region. Also, the first end and the third end are positioned facing one another so that the constant electric field enters the third end and overlaps the fluid flowing in the second direction.

  18. Developments and key issues in tourism mobilities

    OpenAIRE

    Hannam, Kevin; Butler, Gareth; Paris, Cody Morris

    2013-01-01

    This paper examines key developments in recent tourism mobilities research. It begins by outlining the recent conceptualisation of tourism mobilities, arguing that it is not just that tourism is a form of mobility like other forms of mobility but that different mobilities inform and are informed by tourism. It then examines work which has been developed in terms of materialities, autmobilities and new technologies. It concludes by discussing mobile methodologies and some thoughts on future re...

  19. Mobile Learning Using Mobile Phones

    Science.gov (United States)

    Vicente, Paula

    2013-01-01

    The participation in mobile learning programs is conditioned by having/using mobile communication technology. Those who do not have or use such technology cannot participate in mobile learning programs. This study evaluates who are the most likely participants of mobile learning programs by examining the demographic profile and mobile phone usage…

  20. Territory, Rights and Mobility

    DEFF Research Database (Denmark)

    Zhang, Chenchen

    2014-01-01

    attention to the excessive forms of mobility that challenge and break with the official formulation of free movement rights. Thus we turn to the intricate relationship between mobility and citizenship in Europe following our dialogical approach: focusing on the rationalities implied in the government...... of free movement on one hand, and the paths through which to redefine the right to mobility on the other. In the light of Rancière’s reconceptualisation of rights and democracy, I present two examples each employing different strategies to politicise and mobilise mobility: one is through appealing......The overarching objective of this dissertation is to conceptualise the spatiality of citizenship through an exposure to its various others – especially to mobile subjectivity. In particular, it examines the changing patterns of territorialising space, distributing rights and regulating mobility...

  1. Mobility management in mobile IP

    Science.gov (United States)

    Medidi, Sirisha; Golshani, Forouzan

    2002-07-01

    There is an emerging interest in integrating mobile wireless communication with the Internet based on the Ipv6 technology. Many issues introduced by the mobility of users arise when such an integration is attempted. This paper addresses the problem of mobility management, i.e., that of tracking the current IP addresses of mobile terminals and sustaining active IP connections as mobiles move. The paper presents some architectural and mobility management options for integrating wireless access to the Internet. We then present performance results for Mobile IPv4, route optimization and Mobile IPv6.

  2. Isolation and Identification of Putative Oral Cancer Stem Cells

    Institute of Scientific and Technical Information of China (English)

    ZHANG Min; ZHAO Yan-Hua; TANG Xiao-Fei

    2011-01-01

    Objective: To isolate and characterize putative cancer stem cells in Tea8113 oral squmous cell carcinoma cell line. Methods: Putative cancer stem cells were isolated by limited dilution assay in Tea8113 cell line. Biological features of putative cancer stem cells were detected by MTT assay, flow cytometry, immunofluorescence, Colony Forming Efficiency assays, cell motility assay and in vivo tumor formation experiment. Results: Compared with untreated Tea8113 cells, the putative cancer stem cells proliferated more quickly and showed heteroploid cell cycle,higher G0/G1-arrested cells, higher CFE and higher expression levels of ABCG2 belonged to tumor stem cell phenotypes. The putative cancer stem cells had stronger capacity to generate tumors in vivo. Conclusion: The holoclone cells have higher proliferation and self-renewal abilities, which may be cancer stem cells existed in Tea8113 oral squmous cell carcinoma cell line.%目的:分离鉴定口腔鳞癌细胞系Tca8113中的肿瘤干细胞.方法:利用有限稀释的方法分离Tca8113细胞系中的肿瘤干细胞.通过MTT法、流式细胞技术、细胞免疫荧光、克隆形成率分析、细胞迁移能力检测和裸鼠皮下成瘤实验确定分离得到的肿瘤干细胞的生物学特点.结果:分离得到的紧密型克隆肿瘤细胞表现为异倍体样细胞周期,大部分细胞处于G0/G1期,增殖能力、克隆形成率和体外迁移能力都明显高于未分离的肿瘤细胞.紧密型克隆肿瘤细胞肿瘤干细胞标记物ABCG2表达也高于未分离的肿瘤细胞,并且具有更强的裸鼠皮下成瘤能力.结论:我们分离得到的紧密型克隆细胞具有较强的细胞增殖和自我更新能力,可能就是口腔鳞癌细胞系Tca8113中的肿瘤干细胞.

  3. Classification and Evaluation of Mobility Metrics for Mobility Model Movement Patterns in Mobile Ad-Hoc Networks

    Directory of Open Access Journals (Sweden)

    Santosh Kumar S

    2011-10-01

    Full Text Available A mobile ad hoc network is collection of self configuring and adaption of wireless link between communicating devices (mobile devices to form an arbitrary topology and multihop wireless connectivity without the use of existing infrastructure. It requires efficient dynamic routing protocol to determine the routes subsequent to a set of rules that enables two or more devices to communicate with each others. This paper basically classifies and evaluates the mobility metrics into two categories- direct mobility metrics and derived mobility metrics. These two mobility metrics has been used to measure different mobility models, this paper considers some of mobility models i.e Random Waypoint Model, Reference Point Group Mobility Model, Random Direction Mobility Model, Random Walk Mobility Model, Probabilistic Random Walk, Gauss Markov, Column Mobility Model, Nomadic Community Mobility Model and Manhattan Grid Model.

  4. Data Management Infrastructure for the Mobile Web

    DEFF Research Database (Denmark)

    Jensen, Christian Søndergaard

    2009-01-01

    The Internet is going mobile, and indications are that the mobile Internet will be "bigger" than the conventional Internet. Due to aspects such as user mobility, much more diverse use situations, and the form factor of mobile devices, context awareness is important on the mobile Internet. Focusing...... on geo-spatial context awareness, this talk covers research that aims to build infrastructure for mobile data management....

  5. Mobilities Design

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Lanng, Ditte Bendix

    that of ‘mobilities design’. The book revolves around the following research question: How are design decisions and interventions staging mobilities? It builds upon the Staging Mobilities model (Jensen 2013) in an explorative inquiry into the problems and potentials of the design of mobilities. The exchange value...... between mobilities and design research is twofold. To mobilities research this means getting closer to the ‘material’, and to engage in the creative, explorative and experimental approaches of the design world which offer new potentials for innovative research. Design research, on the other hand, might...... enter into a fruitful relationship with mobilities research, offering a relational and mobile design thinking and a valuable base for a reflective design practice around the ubiquitous structures, spaces and systems of mobilities....

  6. Putative archaeal viruses from the mesopelagic ocean.

    Science.gov (United States)

    Vik, Dean R; Roux, Simon; Brum, Jennifer R; Bolduc, Ben; Emerson, Joanne B; Padilla, Cory C; Stewart, Frank J; Sullivan, Matthew B

    2017-01-01

    Oceanic viruses that infect bacteria, or phages, are known to modulate host diversity, metabolisms, and biogeochemical cycling, while the viruses that infect marine Archaea remain understudied despite the critical ecosystem roles played by their hosts. Here we introduce "MArVD", for Metagenomic Archaeal Virus Detector, an annotation tool designed to identify putative archaeal virus contigs in metagenomic datasets. MArVD is made publicly available through the online iVirus analytical platform. Benchmarking analysis of MArVD showed it to be >99% accurate and 100% sensitive in identifying the 127 known archaeal viruses among the 12,499 viruses in the VirSorter curated dataset. Application of MArVD to 10 viral metagenomes from two depth profiles in the Eastern Tropical North Pacific (ETNP) oxygen minimum zone revealed 43 new putative archaeal virus genomes and large genome fragments ranging in size from 10 to 31 kb. Network-based classifications, which were consistent with marker gene phylogenies where available, suggested that these putative archaeal virus contigs represented six novel candidate genera. Ecological analyses, via fragment recruitment and ordination, revealed that the diversity and relative abundances of these putative archaeal viruses were correlated with oxygen concentration and temperature along two OMZ-spanning depth profiles, presumably due to structuring of the host Archaea community. Peak viral diversity and abundances were found in surface waters, where Thermoplasmata 16S rRNA genes are prevalent, suggesting these archaea as hosts in the surface habitats. Together these findings provide a baseline for identifying archaeal viruses in sequence datasets, and an initial picture of the ecology of such viruses in non-extreme environments.

  7. Overproduced Brucella abortus PdhS-mCherry forms soluble aggregates in Escherichia coli, partially associating with mobile foci of IbpA-YFP

    Directory of Open Access Journals (Sweden)

    Matroule Jean-Yves

    2010-09-01

    Full Text Available Abstract Background When heterologous recombinant proteins are produced in Escherichia coli, they often precipitate to form insoluble aggregates of unfolded polypeptides called inclusion bodies. These structures are associated with chaperones like IbpA. However, there are reported cases of "non-classical" inclusion bodies in which proteins are soluble, folded and active. Results We report that the Brucella abortus PdhS histidine kinase fused to the mCherry fluorescent protein forms intermediate aggregates resembling "non-classical" inclusion bodies when overproduced in E. coli, before forming "classical" inclusion bodies. The intermediate aggregates of PdhS-mCherry are characterized by the solubility of PdhS-mCherry, its ability to specifically recruit known partners fused to YFP, suggesting that PdhS is folded in these conditions, and the quick elimination (in less than 10 min of these structures when bacterial cells are placed on fresh rich medium. Moreover, soluble PdhS-mCherry foci do not systematically colocalize with IpbA-YFP, a marker of inclusion bodies. Instead, time-lapse experiments show that IbpA-YFP exhibits rapid pole-to-pole shuttling, until it partially colocalizes with PdhS-mCherry aggregates. Conclusion The data reported here suggest that, in E. coli, recombinant proteins like PdhS-mCherry may transit through a soluble and folded state, resembling previously reported "non-classical" inclusion bodies, before forming "classical" inclusion bodies. The dynamic localization of IbpA-YFP foci suggests that the IbpA chaperone could scan the E. coli cell to find its substrates.

  8. Mobility Divides

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    Contemporary mobilities are cultural and social manifestations, and the mobile practices in the everyday life of billions of humans are re-configuring senses of place, self, other and relationships to the built environment. The way ‘mobile situations’ are staged in designed and built environments...... are increasingly becoming ‘second nature’ but also expressions of power, exclusion, and difference. In this talk I will be applying a perspective of ‘mobile situationism’ illustrating how mobile everyday life practices are staged ‘from above’ in planning and policy frameworks, design codes and architectural...... designs, but also how the situated and embodied mobile everyday life practices are staged ‘from below’ in concrete acts of choice concerning modes of mobilities, ways of moving and interacting. The ‘staging mobilites’ framework opens up to an understanding of the meaning of ‘mobilities design...

  9. Mobile payment

    CERN Document Server

    Lerner, Thomas

    2013-01-01

    Paying with mobile devices such as mobile phones or smart phones will expand worldwide in the coming years. This development provides opportunities for various industries (banking, telecommunications, credit card business, manufacturers, suppliers, retail) and for consumers.

  10. Mobile Lexicography

    DEFF Research Database (Denmark)

    Køhler Simonsen, Henrik

    2015-01-01

    are already mobile – but lexicography is not yet fully ready for the mobile challenge, mobile users and mobile user situations. The article is based on empirical data from two surveys comprising 10 medical doctors, who were asked to look up five medical substances with the medical dictionary app Medicin...... and that lexicographic innovation is needed. A new type of users, new user situations and new access methods call for new lexicographic solutions, and this article proposes a six-pointed hexagram model, which can be used during dictionary app design to lexicographically calibrate the six dimensions in mobile......Mobile phones are ubiquitous and have completely transformed the way we live, work, learn and conduct our everyday activities. Mobile phones have also changed the way users access lexicographic data. In fact, it can be argued that mobile phones and lexicography are not yet compatible. Modern users...

  11. Mobility Divides

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    Contemporary mobilities are cultural and social manifestations, and the mobile practices in the everyday life of billions of humans are re-configuring senses of place, self, other and relationships to the built environment. The way ‘mobile situations’ are staged in designed and built environments...... are increasingly becoming ‘second nature’ but also expressions of power, exclusion, and difference. In this talk I will be applying a perspective of ‘mobile situationism’ illustrating how mobile everyday life practices are staged ‘from above’ in planning and policy frameworks, design codes and architectural...... designs, but also how the situated and embodied mobile everyday life practices are staged ‘from below’ in concrete acts of choice concerning modes of mobilities, ways of moving and interacting. The ‘staging mobilites’ framework opens up to an understanding of the meaning of ‘mobilities design...

  12. Mobile Lexicography

    DEFF Research Database (Denmark)

    Køhler Simonsen, Henrik

    2015-01-01

    Mobile phones are ubiquitous and have completely transformed the way we live, work, learn and conduct our everyday activities. Mobile phones have also changed the way users access lexicographic data. In fact, it can be argued that mobile phones and lexicography are not yet compatible. Modern users...... are already mobile – but lexicography is not yet fully ready for the mobile challenge, mobile users and mobile user situations. The article is based on empirical data from two surveys comprising 10 medical doctors, who were asked to look up five medical substances with the medical dictionary app Medicin...... and that lexicographic innovation is needed. A new type of users, new user situations and new access methods call for new lexicographic solutions, and this article proposes a six-pointed hexagram model, which can be used during dictionary app design to lexicographically calibrate the six dimensions in mobile...

  13. Mobile robots

    Energy Technology Data Exchange (ETDEWEB)

    Wolfe, W.J.; Marquina, N.

    1986-01-01

    This book presents papers given at a conference on mobile robots. Topics the conference included are the following: mobility systems for robotic vehicles; detection and control of mobile robot motion by real-time computer vision, obstacle avoidance algorithms for an autonomous land vehicle; hierarchical processor and matched filters for range image processing; asynchronous distributed control system for a mobile robot, and, planning in a hierarchical nested autonomous control system.

  14. Mobile Lexicography

    DEFF Research Database (Denmark)

    Køhler Simonsen, Henrik

    2014-01-01

    Users are already mobile, but the question is to which extent knowledge-based dictionary apps are designed for the mobile user situation. The objective of this article is to analyse the characteristics of the mobile user situation and to look further into the stationary user situation and the mob...

  15. Mobilities Design

    DEFF Research Database (Denmark)

    Lanng, Ditte Bendix; Wind, Simon; Jensen, Ole B.

    2017-01-01

    utilitarian transport from A to B; they constitute a rich societal phenomenon with, for example, social, cultural, sensorial, emotional, and material dimensions. The article proposes two fruitful links between the mobilities turn and the designerly examination of mobilities spaces. First, the mobilities turn...

  16. Subversive Mobilities

    DEFF Research Database (Denmark)

    Thelle, Mikkel

    2013-01-01

    The article approaches mobility through a cultural history of urban conflict. Using a case of “The Copenhagen Trouble,“ a series of riots in the Danish capital around 1900, a space of subversive mobilities is delineated. These turn-of-the-century riots points to a new pattern of mobile gathering...

  17. Combination of stem cell factor and granulocyte colony-stimulating factor mobilizes the highest number of primitive haemopoietic progenitors as shown by pre-colony-forming unit (pre-CFU) assay.

    Science.gov (United States)

    Horsfall, M J; Hui, C H; To, L B; Begley, C G; Basser, R L; Simmons, P J

    2000-06-01

    Fifty-two patients with poor prognosis carcinoma of the breast underwent peripheral blood stem cell (PBSC) mobilization using five different regimens. The yields of primitive haemopoietic progenitors were quantified by a recently described pre-colony-forming unit (pre-CFU) assay using limiting dilution analysis (LDA). Results of days 14 and 35 pre-CFU were also correlated with conventional CD34+ cell enumeration, CFU-GM (granulocyte-macrophage) and long-term culture-initiating cell (LTCIC) assays. The yield of pre-CFUs with the combination of granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) was significantly higher than with G-CSF alone, cyclophosphamide (Cyclo) and granulocyte-monocyte colony-stimulating factor (GM-CSF), interleukin (IL)-3 and GM-CSF, or Cyclo alone. No significant correlation between neutrophil engraftment and pre-CFU could be demonstrated. Furthermore, CFU-GM was shown to bear a stronger correlation with pre-CFU and LTCIC than CD34+ cell measurement; thus, CFU-GM remains a useful biological tool for haemopoietic stem cell assay. We conclude that the combination of G-CSF and SCF mobilizes the highest number of pre-CFUs as measured by functional pre-CFU assay, which provides an alternative measurement of primitive haemopoietic progenitors to the LTCIC assay.

  18. Towards urban mobility designs

    DEFF Research Database (Denmark)

    Lanng, Ditte Bendix; Harder, Henrik; Jensen, Ole B.

    2012-01-01

    Functionalist traffic design aims at a rational organisation of movement from A to B in a segregated and uniform physical environment. Such urban areas have been criticized for being exclusively functional and lacking sensuous and social qualities. Recent research on mobilities challenges the mor......, in relation to re-conceptualisation of the transit site, to mapping, and to design intervention. These propositions form part of our on-going work with urban mobility designs....

  19. Mobile Tools | Smokefree 60+

    Science.gov (United States)

    These mobile resources can help you quit when you're on the go. SmokefreeTXT SmokefreeTXT is a mobile text messaging service designed for adults across the United States who are trying to quit smoking. The program offers 24/7 encouragement, advice, and tips to help smokers quit smoking and stay quit. If you are interested in signing up, fill out this form.

  20. Determination and Analysis of the Putative AcaCD-Responsive Promoters of Salmonella Genomic Island 1

    Science.gov (United States)

    Olasz, Ferenc; Kiss, János

    2016-01-01

    The integrative genomic island SGI1 and its variants confer multidrug resistance in numerous Salmonella enterica serovariants and several Proteus mirabilis and Acinetobacter strains. SGI1 is mobilized by the IncA/C family plasmids. The island exploits not only the conjugation apparatus of the plasmid, but also utilizes the plasmid-encoded master regulator AcaCD to induce the excision and formation of its transfer-competent form, which is a key step in the horizontal transfer of SGI1. Triggering of SGI1 excision occurs via the AcaCD-dependent activation of xis gene expression. AcaCD binds in Pxis to an unusually long recognition sequence. Beside the Pxis promoter, upstream regions of four additional SGI1 genes, S004, S005, S012 and S018, also contain putative AcaCD-binding sites. Furthermore, SGI1 also encodes an AcaCD-related activator, FlhDCSGI1, which has no known function. Here, we have analysed the functionality of the putative AcaCD-dependent promoter regions and proved their activation by either AcaCD or FlhDCSGI1. Moreover, we provide evidence that both activators act on the same binding site in Pxis and that FlhDCSGI1 is able to complement the acaCD deletion of the IncA/C family plasmid R16a. We determined the transcription start sites for the AcaCD-responsive promoters and showed that orf S004 is expressed probably from a different start codon than predicted earlier. Additionally, expression of S003 from promoter PS004 was ruled out. Pxis and the four SGI1 promoters examined here also lack obvious -35 promoter box and their promoter profile is consistent with the class II-type activation pathway. Although the role of the four additionally analysed AcaCD/FlhDCSGI1-controlled genes in transfer and/or maintenance of SGI1 is not yet clear, the conservation of the whole region suggests the existence of some selection for their functionality. PMID:27727307

  1. Mobile Probes in Mobile Learning

    DEFF Research Database (Denmark)

    Ørngreen, Rikke; Blomhøj, Ulla; Duvaa, Uffe

    as an agent for acquiring empirical data (as the situation in hitherto mobile probe settings) but was also the technological medium for which data should say something about (mobile learning). Consequently, not only the content of the data but also the ways in which data was delivered and handled, provided......In this paper experiences from using mobile probes in educational design of a mobile learning application is presented. The probing process stems from the cultural probe method, and was influenced by qualitative interview and inquiry approaches. In the project, the mobile phone was not only acting...... a valuable dimension for investigating mobile use. The data was collected at the same time as design activities took place and the collective data was analysed based on user experience goals and cognitive processes from interaction design and mobile learning. The mobile probe increased the knowledge base...

  2. Putative cryptoendolithic life in Devonian pillow basalt, Rheinisches Schiefergebirge, Germany.

    Science.gov (United States)

    Peckmann, J; Bach, W; Behrens, K; Reitner, J

    2008-03-01

    Middle Devonian (Givetian) pillow basalt and inter-pillow breccia from the Rheinisches Schiefergebirge in Germany were found to contain putative biogenic filaments that indicate that life once proliferated within these volcanic rocks. Mineralized filaments are found in carbonate amygdules (vesicles filled by carbonate cement) in the volcanic rock, where they started to form on the internal surface of the once water-filled vesicles. Biogenicity of the filaments is indicated by (1) their size and shape resembling modern microorganisms including a constant diameter along the length of curved filaments, (2) their independence of crystal faces or cleavage planes, (3) branching patterns reminiscent of modern microorganisms, and (4) their spatial clustering and preferential occurrence close to the margin of pillows and in the inter-pillow breccias. A time lag between the deposition of pillow basalt and the activity of endoliths is revealed by the sequence of carbonate cements filling the amygdules. The putative filamentous microorganisms thrived after the formation of early fibrous rim cement, but before later equant calcite spar filled most of the remaining porosity. Microbial clay authigenesis analogous to the encrustation of prokaryotes in modern iron-rich environments led to the preservation of filaments. The filaments predominantly consist of the clay minerals chamosite and illite. Having dwelled in water-filled vesicles, the Devonian basalt-hosted filaments apparently represent cryptoendoliths. This finding suggests that a previously unrecognized niche for life exists within volcanic rock.

  3. Mobile Semiotics

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    2013-01-01

    This chapter aims to understand the mobile condition of contemporary life with a particular view to the signifying dimension of the environment and its ‘readability’. The chapter explores the potentials of semiotics and its relationship to the new mobilities literature. What takes place...... is a ‘mobile sense making’ where signs and materially situated meanings connect to the moving human body and thus create particular challenges and complexities of making sense of the world. The chapter includes notions of mobility systems and socio-technical networks in order to show how a ‘semiotic layer’ may...... work to afford or restrict mobile practices....

  4. Staging Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    that mobility is more than movement between point A and B. It explores how the movement of people, goods, information, and signs influences human understandings of self, other and the built environment. Moving towards a new understanding of the relationship between movement, interaction and environments......In recent years, the social sciences have taken a “mobilities turn.” There has been a developing realisation that mobilities do not “just happen.” Mobilities are carefully and meticulously designed, planned and staged (from above). However, they are equally importantly acted out, performed...... and lived as people are “staging themselves” (from below). Staging mobilities is a dynamic process between “being staged” (for example, being stopped at traffic lights) and the “mobile staging” of interacting individuals (negotiating a passage on the pavement). Staging Mobilities is about the fact...

  5. Mobile Lexicography

    DEFF Research Database (Denmark)

    Køhler Simonsen, Henrik

    2014-01-01

    Users are already mobile, but the question is to which extent knowledge-based dictionary apps are designed for the mobile user situation. The objective of this article is to analyse the characteristics of the mobile user situation and to look further into the stationary user situation...... and the mobile user situation. The analysis is based on an empirical survey involving ten medical doctors and a monolingual app designed to support cognitive lexicographic functions, cf. (Tarp 2006:61-64). In test A the doctors looked up five medical terms while sitting down at a desk and in test B the doctors......:565), and it was found that the information access success of the mobile user situation is lower than that of the stationary user situation, primarily because users navigate in the physical world and in the mobile device at the same time. The data also suggest that the mobile user situation is not fully compatible...

  6. 多移动机器人的组队规划研究%Planning method for multiple mobile robots form team.

    Institute of Scientific and Technical Information of China (English)

    李强; 刘国栋

    2011-01-01

    研究了多移动机器人在组队时目标点的优化选取与避障控制问题.依据最近距离最大值优先获得目标点的规则,提出建立机器人与目标位置距离矩阵,并对矩阵进行映射分析,使机器人快速准确地确定对应目标点.采用模糊控制理论,依据经验制定模糊规则,使机器人灵活地避开障碍,仿真实验证明了算法的有效性.%This paper studies the target points optimization select and obstacle-avoiding control problem when multiple mo bile robots form a team. According to the rule that maximum from recent target point is priority to get, distance matrix about the robots away from the target location is proposed,and matrix mapping is analyzed,and makes the robots fast and accurate determinating the corresponding target points.Using fuzzy control theory, fuzzy rules are developed based on human experience,the robots avoid obstacles flexiblely. The simulation results show the effectiveness of the algorithm.

  7. Teaching Form as Form

    DEFF Research Database (Denmark)

    Keiding, Tina Bering

    2012-01-01

    understanding of form per se, or, to use an expression from this text, of form as form. This challenge can be reduced to one question: how can design teaching support students in achieving not only the ability to recognize and describe different form-related concepts in existing design (i.e. analytical...... means that form serves both as the connective value and as the concept for reflection. In other words, form is observed as form, not anything else. The didactical challenge of teaching form as form is accentuated by students’ everyday-based pre-orientation towards function at the expense of form....... In general, students enter design education as far more skilled observers with regards to function than form. They are, in other words, predisposed to observe objects asking ‘what is?’, rather than ‘how is?’. This habit has not only cognitive implications. It is closely intertwined with a rudimentary...

  8. Teaching Form as Form

    DEFF Research Database (Denmark)

    Keiding, Tina Bering

    2012-01-01

    understanding of form per se, or, to use an expression from this text, of form as form. This challenge can be reduced to one question: how can design teaching support students in achieving not only the ability to recognize and describe different form-related concepts in existing design (i.e. analytical...... means that form serves both as the connective value and as the concept for reflection. In other words, form is observed as form, not anything else. The didactical challenge of teaching form as form is accentuated by students’ everyday-based pre-orientation towards function at the expense of form...... vocabulary of form. Even in cases in which teaching uses terms and phrases from everyday life (for instance, ‘intersection’), the meaning of the word cannot necessarily be transmitted directly from an ordinary vocabulary into a design context. And it is clearly a common issue for the contributions...

  9. Ten Putative Contributors to the Obesity Epidemic

    Science.gov (United States)

    McAllister, Emily J.; Dhurandhar, Nikhil V.; Keith, Scott W.; Aronne, Louis J.; Barger, Jamie; Baskin, Monica; Benca, Ruth M.; Biggio, Joseph; Boggiano, Mary M.; Eisenmann, Joe C.; Elobeid, Mai; Fontaine, Kevin R.; Gluckman, Peter; Hanlon, Erin C.; Katzmarzyk, Peter; Pietrobelli, Angelo; Redden, David T.; Ruden, Douglas M.; Wang, Chenxi; Waterland, Robert A.; Wright, Suzanne M.; Allison, David B.

    2010-01-01

    The obesity epidemic is a global issue and shows no signs of abating, while the cause of this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally-driven declines in physical activity are the alleged perpetrators for the epidemic, despite a lack of solid evidence to demonstrate their causal role. While both may contribute to obesity, we call attention to their unquestioned dominance in program funding and public efforts to reduce obesity, and propose several alternative putative contributors that would benefit from equal consideration and attention. Evidence for microorganisms, epigenetics, increasing maternal age, greater fecundity among people with higher adiposity, assortative mating, sleep debt, endocrine disruptors, pharmaceutical iatrogenesis, reduction in variability of ambient temperatures, and intrauterine and intergenerational effects, as contributing factors to the obesity epidemic are reviewed herein. While the evidence is strong for some contributors such as pharmaceutical-induced weight gain, it is still emerging for other reviewed factors. Considering the role of such putative etiological factors of obesity may lead to comprehensive, cause specific, and effective strategies for prevention and treatment of this global epidemic. PMID:19960394

  10. Structure determination and biochemical characterization of a putative HNH endonuclease from Geobacter metallireducens GS-15.

    Directory of Open Access Journals (Sweden)

    Shuang-yong Xu

    Full Text Available The crystal structure of a putative HNH endonuclease, Gmet_0936 protein from Geobacter metallireducens GS-15, has been determined at 2.6 Å resolution using single-wavelength anomalous dispersion method. The structure contains a two-stranded anti-parallel β-sheet that are surrounded by two helices on each face, and reveals a Zn ion bound in each monomer, coordinated by residues Cys38, Cys41, Cys73, and Cys76, which likely plays an important structural role in stabilizing the overall conformation. Structural homologs of Gmet_0936 include Hpy99I endonuclease, phage T4 endonuclease VII, and other HNH endonucleases, with these enzymes sharing 15-20% amino acid sequence identity. An overlay of Gmet_0936 and Hpy99I structures shows that most of the secondary structure elements, catalytic residues as well as the zinc binding site (zinc ribbon are conserved. However, Gmet_0936 lacks the N-terminal domain of Hpy99I, which mediates DNA binding as well as dimerization. Purified Gmet_0936 forms dimers in solution and a dimer of the protein is observed in the crystal, but with a different mode of dimerization as compared to Hpy99I. Gmet_0936 and its N77H variant show a weak DNA binding activity in a DNA mobility shift assay and a weak Mn²⁺-dependent nicking activity on supercoiled plasmids in low pH buffers. The preferred substrate appears to be acid and heat-treated DNA with AP sites, suggesting Gmet_0936 may be a DNA repair enzyme.

  11. Ballistic gelatin as a putative substrate for EEG phantom devices

    CERN Document Server

    Hairston, W David; Yu, Alfred B

    2016-01-01

    Phantom devices allow the human variable to be controlled for in order to allow clear comparison and validation of biomedical imaging hardware and software. There is currently no standard phantom for electroencephalography (EEG). To be useful, such a device would need to: (a) accurately recreate the real and imaginary components of scalp electrical impedance, (b) contain internal emitters to create electrical dipoles, and (c) be easily replicable across various labs and research groups. Cost-effective materials, which are conductive, repeatable, and easily formed are a missing key enabler for EEG phantoms. Here, we explore the use of ballistics gelatin, an inexpensive, easily-formable and repeatable material, as a putative substrate by examining its electrical properties and physical stability over time. We show that varied concentrations of NaCl salt relative to gelatin powder shifts the phase/frequency response profile, allowing for selective tuning of the material electrical properties.

  12. Mobilities Design

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Lanng, Ditte Bendix; Wind, Simon

    2016-01-01

    In this paper, we identify the nexus between design (architecture, urban design, service design, etc.) and mobilities as a new and emerging research field. In this paper, we apply a “situational mobilities” perspective and take point of departure in the pragmatist question: “What design decisions...... and interventions affords this particular mobile situation?” The paper presents the contours of an emerging research agenda within mobilities research. The advent of “mobilities design” as an emerging research field points towards a critical interest in the material as well as practical consequences of contemporary...... sites of mobilities and technology. Furthermore, the paper argues that heightened material sensitivity with an acute focus on situations and the multi-sensorial dimensions of human mobilities is largely under-prioritised within much contemporary city planning and transport planning as well as policy...

  13. Designing Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    of departure in the sociological perspective termed ‘Staging Mobilities’ (Jensen 2013a) and utilizes this as an analytical frame for exploring cases of mobility design. The paper put focus on how the material shape, design and architectures of technologies, spaces and sites influence mobilities practices......, mobilitiy technologies or urban sites of movement we get much closer to understanding the meaning of mobilities to social interaction and culture. The cases are still representing work-in-progress but will be reported in the book ‘Designing Mobilites’ (Jensen 2013b) and will cover the four cases of......Within the so-called ‘mobilities turn’ (Adey 2010; Cresswell 2006; Urry 2007) much research has taken place during the last decade bringing mobilities into the centre of sociological analysis. However, the materiality and spatiality of artefacts, infrastructures, and sites hosting mobilities...

  14. Mobilities Design

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Lanng, Ditte Bendix; Wind, Simon

    2016-01-01

    In this paper, we identify the nexus between design (architecture, urban design, service design, etc.) and mobilities as a new and emerging research field. In this paper, we apply a “situational mobilities” perspective and take point of departure in the pragmatist question: “What design decisions...... and interventions affords this particular mobile situation?” The paper presents the contours of an emerging research agenda within mobilities research. The advent of “mobilities design” as an emerging research field points towards a critical interest in the material as well as practical consequences of contemporary......-making. The paper proposes that increased understanding of the material affordances facilitated through design provides important insight to planning and policymaking that at times might be in risk of becoming too detached from the everyday life of the mobile subject within contemporary mobilities landscapes....

  15. Mobile Semiotics

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    2013-01-01

    This chapter aims to understand the mobile condition of contemporary life with a particular view to the signifying dimension of the environment and its ‘readability’. The chapter explores the potentials of semiotics and its relationship to the new mobilities literature. What takes place is a ‘mob......This chapter aims to understand the mobile condition of contemporary life with a particular view to the signifying dimension of the environment and its ‘readability’. The chapter explores the potentials of semiotics and its relationship to the new mobilities literature. What takes place...... is a ‘mobile sense making’ where signs and materially situated meanings connect to the moving human body and thus create particular challenges and complexities of making sense of the world. The chapter includes notions of mobility systems and socio-technical networks in order to show how a ‘semiotic layer’ may...

  16. Designing Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    , mobilitiy technologies or urban sites of movement we get much closer to understanding the meaning of mobilities to social interaction and culture. The cases are still representing work-in-progress but will be reported in the book ‘Designing Mobilites’ (Jensen 2013b) and will cover the four cases of......Within the so-called ‘mobilities turn’ (Adey 2010; Cresswell 2006; Urry 2007) much research has taken place during the last decade bringing mobilities into the centre of sociological analysis. However, the materiality and spatiality of artefacts, infrastructures, and sites hosting mobilities...... of departure in the sociological perspective termed ‘Staging Mobilities’ (Jensen 2013a) and utilizes this as an analytical frame for exploring cases of mobility design. The paper put focus on how the material shape, design and architectures of technologies, spaces and sites influence mobilities practices...

  17. Mobile Clouds

    DEFF Research Database (Denmark)

    Fitzek, Frank; Katz, Marcos

    users in very different ways and for various purposes. The book provides many stimulating examples of resource-sharing applications. Enabling technologies for mobile clouds are also discussed, highlighting the key role of network coding. Mobile clouds have the potential to enhance communications...... of resource sharing takes a wider and deeper meaning, creating the foundations for a global real-time multidimensional resource pool, the underlying infrastructure for shareconomy. Above all, this is an inspiring book for anyone who is concerned about the future of wireless and mobile communications networks...... and their relationship with Social networks. Key Features: Provides fundamental ideas and promising concepts for exploiting opportunistic cooperation and cognition in wireless and mobile networks Gives clear definitions of mobile clouds from different perspectives Associates mobile and wireless networks with social...

  18. Mobility Work

    DEFF Research Database (Denmark)

    Bardram, Jakob Eyvind; Bossen, Claus

    2005-01-01

    We posit the concept of Mobility Work to describe efforts of moving about people and things as part of accomplishing tasks. Mobility work can be seen as a spatial parallel to the concept of articulation work proposed by the sociologist Anselm Strauss. Articulation work describes efforts...... of coordination necessary in cooperative work, but focuses, we argue, mainly on the temporal aspects of cooperative work. As a supplement, the concept of mobility work focuses on the spatial aspects of cooperative work. Whereas actors seek to diminish the amount of articulation work needed in collaboration...... by constructing Standard Operation Procedures (SOPs), actors minimise mobility work by constructing Standard Operation Configurations (SOCs). We apply the concept of mobility work to the ethnography of hospital work, and argue that mobility arises because of the need to get access to people, places, knowledge and...

  19. Mobility Work

    DEFF Research Database (Denmark)

    Bardram, Jakob Eyvind; Bossen, Claus

    2005-01-01

    by constructing Standard Operation Procedures (SOPs), actors minimise mobility work by constructing Standard Operation Configurations (SOCs). We apply the concept of mobility work to the ethnography of hospital work, and argue that mobility arises because of the need to get access to people, places, knowledge and....../or resources. To accomplish their work, actors have to make the right configuration of these four aspects emerge....

  20. Mobile museology

    DEFF Research Database (Denmark)

    Baggesen, Rikke Haller

    Drawing together perspectives from museology, digital culture studies and fashion theory, this thesis considers changes in and challenges for current - day museums as related to ‘mobile museology’. This concept is developed for and elucidated in the thesis to describe an orientation towards...... the fashionable, the ephemeral, and towards an (ideal) state of change and changeability. This orientation is characterised with the triplet concepts of mobile, mobility, and mobilisation, as related to mobile media and movability; to ‘trans - museal’ mediation; and to the mobilisation of collections, audiences...

  1. Privacy issues in mobile advertising

    DEFF Research Database (Denmark)

    Cleff, Evelyne Beatrix

    The emergence of the wired Internet and mobile telecommunication networks is creating new opportunities for advertisers to generate new revenue streams through mobile users. As consumer adoption of mobile technology continues to increase, it is only a question of time when mobile advertising...... becomes an important part of marketing strategies. The development of mobile advertising, however, will be dependent on acceptance and usability issues in order to ensure permission-based advertising. Growing concerns about the protection of the users' privacy have been raised since mobile advertising may...... become extremely intrusive practices in an intimate personal space. This article focuses on the evaluation of legal problems raised by this novel form of advertising. It is assumed that a technological design, which is in line with the legal framework, will ensure that the benefits of mobile advertising...

  2. Privacy issues in mobile advertising

    DEFF Research Database (Denmark)

    Cleff, Evelyne Beatrix

    2007-01-01

    The emergence of the wired Internet and mobile telecommunication networks is creating new opportunities for advertisers to generate new revenue streams through mobile users. As consumer adoption of mobile technology continues to increase, it is only a question of time when mobile advertising...... becomes an important part of marketing strategies. The development of mobile advertising, however, will be dependent on acceptance and usability issues in order to ensure permission-based advertising. Growing concerns about the protection of the users' privacy have been raised since mobile advertising may...... become extremely intrusive practices in an intimate personal space. This article focuses on the evaluation of legal problems raised by this novel form of advertising. It is assumed that a technological design, which is in line with the legal framework, will ensure that the benefits of mobile advertising...

  3. Privacy issues in mobile advertising

    DEFF Research Database (Denmark)

    Cleff, Evelyne Beatrix

    2007-01-01

    The emergence of the wired Internet and mobile telecommunication networks is creating new opportunities for advertisers to generate new revenue streams through mobile users. As consumer adoption of mobile technology continues to increase, it is only a question of time when mobile advertising...... become extremely intrusive practices in an intimate personal space. This article focuses on the evaluation of legal problems raised by this novel form of advertising. It is assumed that a technological design, which is in line with the legal framework, will ensure that the benefits of mobile advertising...... becomes an important part of marketing strategies. The development of mobile advertising, however, will be dependent on acceptance and usability issues in order to ensure permission-based advertising. Growing concerns about the protection of the users' privacy have been raised since mobile advertising may...

  4. Privacy issues in mobile advertising

    DEFF Research Database (Denmark)

    Cleff, Evelyne Beatrix

    The emergence of the wired Internet and mobile telecommunication networks is creating new opportunities for advertisers to generate new revenue streams through mobile users. As consumer adoption of mobile technology continues to increase, it is only a question of time when mobile advertising...... become extremely intrusive practices in an intimate personal space. This article focuses on the evaluation of legal problems raised by this novel form of advertising. It is assumed that a technological design, which is in line with the legal framework, will ensure that the benefits of mobile advertising...... becomes an important part of marketing strategies. The development of mobile advertising, however, will be dependent on acceptance and usability issues in order to ensure permission-based advertising. Growing concerns about the protection of the users' privacy have been raised since mobile advertising may...

  5. Putative Nitrogen Sensing Systems in Higher Plants

    Institute of Scientific and Technical Information of China (English)

    Hon-Ming Lam; Ying Ann Chiao; Man-Wah Li; Yuk-Kwong Yung; Sang Ji

    2006-01-01

    Nitrogen (N) metabolism is essential for the biosynthesis of vital biomolecules. N status thus exerts profound effects on plant growth and development, and must be closely monitored. In bacteria and fungi, a few sophisticated N sensing systems have been extensively studied. In animals, the ability to receive amino acid signals has evolved to become an integral part of the nervous coordination system. In this review, we will summarize recent developments in the search for putative N sensing systems in higher plants based on homologous systems in bacteria, fungi, and animals. Apparently, although plants have separated and diversified from other organisms during the evolution process, striking similarities can be found in their N sensing systems compared with those of their counterparts; however, our understanding of these systems is still incomplete. Significant modifications of the N sensing systems (including cross-talk with other signal transduction pathways) in higher plants may be a strategy of adaptation to their unique mode of life.

  6. Putative respiratory chain of Porphyromonas gingivalis.

    Science.gov (United States)

    Meuric, Vincent; Rouillon, Astrid; Chandad, Fatiha; Bonnaure-Mallet, Martine

    2010-05-01

    The electron transfer chain in Porphyromonas gingivalis, or periodontopathogens, has not yet been characterized. P. gingivalis, a strict anaerobic bacteria and the second colonizer of the oral cavity, is considered to be a major causal agent involved in periodontal diseases. Primary colonizers create a favorable environment for P. gingivalis growth by decreasing oxygen pressure. Oxygen does not appear to be the final electron acceptor of the respiratory chain. Fumarate and cytochrome b have been implicated as major components of the respiratory activity. However, the P. gingivalis genome shows many other enzymes that could be implicated in aerobic or nitrite respiration. Using bioinformatic tools and literature studies of respiratory pathways, the ATP synthesis mechanism from the sodium cycle and nutrients metabolism, the putative respirasome of P. gingivalis has been proposed.

  7. Molecular diagnosis of putative Stargardt disease by capture next generation sequencing.

    Science.gov (United States)

    Zhang, Xiao; Ge, Xianglian; Shi, Wei; Huang, Ping; Min, Qingjie; Li, Minghan; Yu, Xinping; Wu, Yaming; Zhao, Guangyu; Tong, Yi; Jin, Zi-Bing; Qu, Jia; Gu, Feng

    2014-01-01

    Stargardt Disease (STGD) is the commonest genetic form of juvenile or early adult onset macular degeneration, which is a genetically heterogeneous disease. Molecular diagnosis of STGD remains a challenge in a significant proportion of cases. To address this, seven patients from five putative STGD families were recruited. We performed capture next generation sequencing (CNGS) of the probands and searched for potentially disease-causing genetic variants in previously identified retinal or macular dystrophy genes. Seven disease-causing mutations in ABCA4 and two in PROM1 were identified by CNGS, which provides a confident genetic diagnosis in these five families. We also provided a genetic basis to explain the differences among putative STGD due to various mutations in different genes. Meanwhile, we show for the first time that compound heterozygous mutations in PROM1 gene could cause cone-rod dystrophy. Our findings support the enormous potential of CNGS in putative STGD molecular diagnosis.

  8. Mobile Semiotics - signs and mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    This paper is about how to comprehend the mobile condition of contemporary life with a particular view to the signifying dimension of the environment and its ‘readability’. The paper explores the potentials of semiotics and its relationship to the new mobilities literature. The theoretical scope...... is therefore an attempt to mobilize semiotics by drawing on a central body of theory within and adjacent to the discipline. For instance the founding works of C. S. Peirce will be related to the contemporary notions of ‘geosemiotics’ by Scollon & Scollon. The paper’s theoretical claim is that semiotics hold...... a potential for mobilities studies if the awareness of seeing the environment as a semiotic layer and system can be sensitized to the insights of the ‘mobilities turn’. Empirically the paper tentatively explores the usefulness of a mobile semiotics approach to cases such as street signage, airport design...

  9. Mobile phones and mobile communication

    DEFF Research Database (Denmark)

    Ling, Richard; Donner, Jonathan

    With staggering swiftness, the mobile phone has become a fixture of daily life in almost every society on earth. In 2007, the world had over 3 billion mobile subscriptions. Prosperous nations boast of having more subscriptions than people. In the developing world, hundreds of millions of people who...... could never afford a landline telephone now have a mobile number of their own. With a mobile in our hand many of us feel safer, more productive, and more connected to loved ones, but perhaps also more distracted and less involved with things happening immediately around us. Written by two leading...... researchers in the field, this volume presents an overview of the mobile telephone as a social and cultural phenomenon. Research is summarized and made accessible though detailed descriptions of ten mobile users from around the world. These illustrate popular debates, as well as deeper social forces at work...

  10. Management of Mobile Web Application Development with Quality Assurance

    OpenAIRE

    Alin Zamfiroiu; Bogdan Vintila

    2013-01-01

    Mobile applications are becoming increasingly used because of the multitude of existing mobile devices. Mobile application development becomes more complex. For mobile devices there are native applications that run directly on the device, web applications accessed via mobile browsers and hybrid applications. Mobile Application Development in any form should be made with quality assurance since when determining the target group and the application architecture. Management of mobile application...

  11. Mobile Clouds

    DEFF Research Database (Denmark)

    Fitzek, Frank; Katz, Marcos

    examples of mobile clouds applications, based on both existing commercial initiatives as well as proof-of-concept test-beds. Visions and prospects are also discussed, paving the way for further development. As mobile networks and social networks become more and more reliant on each other, the concept...

  12. Residential mobility

    DEFF Research Database (Denmark)

    Morris, Tim; Manley, David; Sabel, Clive

    2016-01-01

    lacks the detail and temporal perspectives now seen as critical to understanding residential mobility decisions. Through a critical re-think of mobility processes with respect to health outcomes and an exploitation of longitudinal analytical techniques we argue that health geographers have the potential...

  13. Staging Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    In recent years, the social sciences have taken a “mobilities turn.” There has been a developing realisation that mobilities do not “just happen.” Mobilities are carefully and meticulously designed, planned and staged (from above). However, they are equally importantly acted out, performed...... that mobility is more than movement between point A and B. It explores how the movement of people, goods, information, and signs influences human understandings of self, other and the built environment. Moving towards a new understanding of the relationship between movement, interaction and environments......, the book asks: what are the physical, social, technical, and cultural conditions to the staging of contemporary urban mobilities?...

  14. Designing Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    How is the width of the pavement shaping the urban experience? How is the material design of transport infrastructure and mobile technology affording social interaction in everyday life spaces? How do people inhabit these spaces with their bodies and in accordance to social and cultural norms......? These are some of the questions that this book raises in order to explore how the design of mobile sites and situations affect people's everyday life. The book takes point of departure in the author's book 'Staging Mobilities' (Routledge, 2013) in which it is argued that mobility is much more than simple...... acts of moving in the city. 'Designing Mobilities' is based on more than a decade of academic research by Professor of Urban Theory, Ole B. Jensen and a must-read for students and scholars with an interest in urban studies, urban design, architecture, urban planning, transport planning and geography...

  15. In vitro culture and characterization of putative porcine embryonic germ cells derived from domestic breeds and yucatan mini pig embryos at days 20-24 of gestation

    DEFF Research Database (Denmark)

    Petkov, Stoyan Gueorguiev; Marks, Hendrik; Klein, Tino

    2011-01-01

    annotation clustering of the gene expression pattern of the putative EGC suggests partial differentiation toward endo/mesodermal lineages. The putative EGC were able to form embryoid bodies in suspension culture and to differentiate into epithelial-like, mesenchymal-like, and neuronal-like cells. However...

  16. Mobile probes

    DEFF Research Database (Denmark)

    2016-01-01

    A project investigating the effectiveness of a collection of online resources for teachers' professional development used mobile probes as a data collection method. Teachers received questions and tasks on their mobile in a dialogic manner while in their everyday context as opposed to in an inter......A project investigating the effectiveness of a collection of online resources for teachers' professional development used mobile probes as a data collection method. Teachers received questions and tasks on their mobile in a dialogic manner while in their everyday context as opposed...... to in an interview. This method provided valuable insight into the contextual use, i.e. how did the online resource transfer to the work practice. However, the research team also found that mobile probes may provide the scaffolding necessary for individual and peer learning at a very local (intra-school) community...... level. This paper is an initial investigation of how the mobile probes process proved to engage teachers in their efforts to improve teaching. It also highlights some of the barriers emerging when applying mobile probes as a scaffold for learning....

  17. Composition of the Putative Prepore Complex of Bacillus thuringiensis Cry1Ab Toxin

    Science.gov (United States)

    Nair, Manoj S.; Dean, Donald H.

    2015-01-01

    Prepore formation is hypothesized to be an obligate step in the insertion of Cry1Ab toxin into insect brush border membrane vesicles. We examined the architecture of the putative prepore when isolated using the published protocols [1] [2]. Our results demonstrate that the putative prepore form of Cry1Ab is a combination of receptor proteins attached to the toxin, when purified. The results also suggest that this prepore form as prepared by the methods published is different from other membrane-extracted oligomeric forms of Cry toxins and prepore of other toxins in general. While most other known prepores are composed of multimers of a single protein, the Cry1Ab prepore, as generated, is a protein-receptor complex oligomer and monomers of Cry toxins. PMID:26702367

  18. The Biogeography of Putative Microbial Antibiotic Production.

    Directory of Open Access Journals (Sweden)

    Hélène Morlon

    Full Text Available Understanding patterns in the distribution and abundance of functional traits across a landscape is of fundamental importance to ecology. Mapping these distributions is particularly challenging for species-rich groups with sparse trait measurement coverage, such as flowering plants, insects, and microorganisms. Here, we use likelihood-based character reconstruction to infer and analyze the spatial distribution of unmeasured traits. We apply this framework to a microbial dataset comprised of 11,732 ketosynthase alpha gene sequences extracted from 144 soil samples from three continents to document the spatial distribution of putative microbial polyketide antibiotic production. Antibiotic production is a key competitive strategy for soil microbial survival and performance. Additionally, novel antibiotic discovery is highly relevant to human health, making natural antibiotic production by soil microorganisms a major target for bioprospecting. Our comparison of trait-based biogeographical patterns to patterns based on taxonomy and phylogeny is relevant to our basic understanding of microbial biogeography as well as the pressing need for new antibiotics.

  19. Mechanosensory neurons, cutaneous mechanoreceptors, and putative mechanoproteins.

    Science.gov (United States)

    Del Valle, M E; Cobo, T; Cobo, J L; Vega, J A

    2012-08-01

    The mammalian skin has developed sensory structures (mechanoreceptors) that are responsible for different modalities of mechanosensitivity like touch, vibration, and pressure sensation. These specialized sensory organs are anatomically and functionally connected to a special subset of sensory neurons called mechanosensory neurons, which electrophysiologically correspond with Aβ fibers. Although mechanosensory neurons and cutaneous mechanoreceptors are rather well known, the biology of the sense of touch still remains poorly understood. Basically, the process of mechanosensitivity requires the conversion of a mechanical stimulus into an electrical signal through the activation of ion channels that gate in response to mechanical stimuli. These ion channels belong primarily to the family of the degenerin/epithelium sodium channels, especially the subfamily acid-sensing ion channels, and to the family of transient receptor potential channels. This review compiles the current knowledge on the occurrence of putative mechanoproteins in mechanosensory neurons and mechanoreceptors, as well as the involvement of these proteins on the biology of touch. Furthermore, we include a section about what the knock-out mice for mechanoproteins are teaching us. Finally, the possibilities for mechanotransduction in mechanoreceptors, and the common involvement of the ion channels, extracellular membrane, and cytoskeleton, are revisited.

  20. AN AGENT BASED TRANSACTION PROCESSING SCHEME FOR DISCONNECTED MOBILE NODES

    Directory of Open Access Journals (Sweden)

    J.L. Walter Jeyakumar

    2010-12-01

    Full Text Available We present a mobile transaction framework in which mobile users can share data which is stored in the cache of a mobile agent. This mobile agent is a special mobile node which coordinates the sharing process. The proposed framework allows mobile affiliation work groups to be formed dynamically with a mobile agent and mobile hosts. Using short range wireless communication technology, mobile users can simultaneously access the data from the cache of the mobile agent. The data Access Manager module at the mobile agent enforces concurrency control using cache invalidation technique. This model supports disconnected mobile computing allowing mobile agent to move along with the Mobile Hosts. The proposed Transaction frame work has been simulated in Java 2 and performance of this scheme is compared with existing frame works.

  1. Mobilities Design

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Lanng, Ditte Bendix

    2016-01-01

    of increasing concern and societal importance, regardless if the focus is on new inequalities, environmental sustainability, or the meaning of vernacular mobilities design to the everyday life. The theme of ‘mobilities design’ opens up the agenda of architectural research into infrastructure spaces as ‘spaces...... insights, concepts of space and place, and relations between fixities and flows. The new and emerging field of ‘mobilities design’ will be exploring the borderlines between architecture, urban design, urban planning, and infrastructure design. The field will address the ‘gap’ in research on an issue...... of life’ for billions of people in the everyday life. This paper is structured in three parts. After the general introduction we present the mobilities theory perspective of ‘staging mobilities’ and connects this to the empirical phenomenon of parking lots and their design. The paper ends in section three...

  2. Mobile Learning

    Directory of Open Access Journals (Sweden)

    Anke Petschenka

    2014-03-01

    Full Text Available Rezension zu: de Witt, Claudia, und Almut Sieber, Hrsg. 2013. Mobile Learning: Potenziale, Einsatzszenarien und Perspektiven des Lernens mit mobilen Endgeräten. Wiesbaden: Springer VS.

  3. Designing Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    How is the width of the pavement shaping the urban experience? How is the material design of transport infrastructure and mobile technology affording social interaction in everyday life spaces? How do people inhabit these spaces with their bodies and in accordance to social and cultural norms......? These are some of the questions that this book raises in order to explore how the design of mobile sites and situations affect people's everyday life. The book takes point of departure in the author's book 'Staging Mobilities' (Routledge, 2013) in which it is argued that mobility is much more than simple...... movements of people, goods, and information 'from A to B'. Accordingly, the way people, goods, and information moves shapes the way we understand our built environment, other consociates, and ourselves. The book contributes with a new and critical-creative gaze on what might seem to be trivial and mundane...

  4. Mobile museology

    DEFF Research Database (Denmark)

    Baggesen, Rikke Haller

    posts from the research project blog with three research articles: ‘Museum metamorphosis à la mode’, proposing a fashion perspective on ongoing museum developments; ‘Augmenting the agora: media and civic engagement in museums’, questioning the idea of social media holding a vital potential......Drawing together perspectives from museology, digital culture studies and fashion theory, this thesis considers changes in and challenges for current - day museums as related to ‘mobile museology’. This concept is developed for and elucidated in the thesis to describe an orientation towards...... the fashionable, the ephemeral, and towards an (ideal) state of change and changeability. This orientation is characterised with the triplet concepts of mobile, mobility, and mobilisation, as related to mobile media and movability; to ‘trans - museal’ mediation; and to the mobilisation of collections, audiences...

  5. Mobile Commerce

    Directory of Open Access Journals (Sweden)

    Maria Cristina Enache

    2016-07-01

    Full Text Available Mobile commerce, or m-commerce, refers to the use of wireless digital devices to enable transactions on the Web. Described more fully in Chapter 3, m-commerce involves the use of wireless networks to connect cell phones, handheld devices such Blackberries, and personal computers to the Web. Once connected, mobile consumers can conduct transactions, including stock trades, in-store price comparisons, banking, travel reservations, and more.

  6. Territory, Rights and Mobility

    DEFF Research Database (Denmark)

    Zhang, Chenchen

    2014-01-01

    looks at two different notions of territory – a statist one and a networked one – that are visible in the official discourses, yet it highlights the fact that the technologies that are supposed to produce each type of territoriality often converge. Thus I read the politics of Eurostar and the Channel...... attention to the excessive forms of mobility that challenge and break with the official formulation of free movement rights. Thus we turn to the intricate relationship between mobility and citizenship in Europe following our dialogical approach: focusing on the rationalities implied in the government...

  7. Mobility Challenges

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Lassen, Claus

    2011-01-01

    This article takes point of departure in the challenges to understand the importance of contemporary mobility. The approach advocated is a cross-disciplinary one drawing on sociology, geography, urban planning and design, and cultural studies. As such the perspective is to be seen as a part of th...... mobilities. In particular the article discusses 1) the physical city, its infrastructures and technological hardware/software, 2) policies and planning strategies for urban mobility and 3) the lived everyday life in the city and the region.......This article takes point of departure in the challenges to understand the importance of contemporary mobility. The approach advocated is a cross-disciplinary one drawing on sociology, geography, urban planning and design, and cultural studies. As such the perspective is to be seen as a part...... of the so-called ‘mobility turn’ within social science. The perspective is illustrative for the research efforts at the Centre for Mobility and Urban Studies (C-MUS), Aalborg University. The article presents the contours of a theoretical perspective meeting the challenges to research into contemporary urban...

  8. Management of Mobile Web Application Development with Quality Assurance

    Directory of Open Access Journals (Sweden)

    Alin Zamfiroiu

    2013-06-01

    Full Text Available Mobile applications are becoming increasingly used because of the multitude of existing mobile devices. Mobile application development becomes more complex. For mobile devices there are native applications that run directly on the device, web applications accessed via mobile browsers and hybrid applications. Mobile Application Development in any form should be made with quality assurance since when determining the target group and the application architecture. Management of mobile application development is the result obtained and the quality of applications developed in the decisions taken. In this paper decisions made in the development of mobile web applications are presented and how this mobile web application is used by the students.

  9. Evaluating the function of putative hormone transporters.

    Science.gov (United States)

    Frommer, Wolf B; Schulz, Burkhard; Murphy, Angus S

    2009-02-01

    Hormones typically serve as long distance signaling molecules. To reach their site of action, hormones need to be transported from the sites of synthesis. Many plant hormones are mobile, thus requiring specific transport systems for the export from their source cells as well as subsequent import into target cells. Hormone transport in general is still poorly understood. Auxin is probably the most intensively studied plant hormone concerning transport in the moment. To advance our understanding of hormone transport we need two principal data sets: information on the properties of the transport systems including substrate specificity and kinetics, and we need to identify candidate genes for the respective transporters. Physiological transport data can provide an important basis for identifying and characterizing candidate transporters and to define their in vivo role. A recent publication in Plant Physiology highlights how kinetic and specificity studies may help to identify cytokinin transporters.

  10. Intensive mobilities:

    DEFF Research Database (Denmark)

    Vannini, Phillip; Bissell, David; Jensen, Ole B.

    This paper explores the intensities of long distance commuting journeys as a way of exploring how bodily sensibilities are being changed by the mobilities that they undertake. The context of this paper is that many people are travelling further to work than ever before owing to a variety of facto....... By exploring how experiences of long-distance workers become constituted by a range of different material forces enables us to more sensitively consider the practical, technical, and political implications of this increasingly prevalent yet underexplored regime of work....... which relate to transport, housing and employment. Yet we argue that the experiential dimensions of long distance mobilities have not received the attention that they deserve within geographical research on mobilities. This paper combines ideas from mobilities research and contemporary social theory...... with fieldwork conducted in Canada, Denmark and Australia to develop our understanding of the experiential politics of long distance workers. Rather than focusing on the extensive dimensions of mobilities that are implicated in patterns and trends, our paper turns to the intensive dimensions of this experience...

  11. Collaborative form(s)

    DEFF Research Database (Denmark)

    Gunn, Wendy

    Gunn asks us to consider beauty as collaborative forms of action generated by moving between design by means of anthropology and anthropology by means of design. Specifically, she gives focus to play-like reflexions on practices of designing energy products, systems and infrastructure. Design...

  12. A new putative alphapartitivirus recovered from the powdery mildew fungus Erysiphe palczewskii.

    Science.gov (United States)

    Xiong, Guihong; Qiu, Ping; Li, Cong; Chen, Zhuo; Islam, Saif Ul; Fang, Shouguo; Wu, Zujian; Zhang, Songbai; Du, Zhenguo

    2017-02-27

    Two double-stranded RNAs (dsRNA) likely representing the genome of a novel alphapartitivirus which we provisionally named Erysiphe palczewskii alphapartitivirus 1 (EpV1) were recovered from the powdery mildew fungus E. palczewskii infecting Sophora japonica in Jingzhou, Hubei province of China. The two dsRNAs, 1955 (dsRNA1) and 1917 (dsRNA2) bp in size, respectively, each contains a single open reading frame (ORF) encoding a 585- and 528-aa protein, respectively. The 585-aa protein contains a conserved RNA-dependent RNA polymerase (RdRp) domain and shows significant homology to RdRps of approved or putative partitiviruses, particularly those belonging to the genus Alphapartitivirus. However, it shares an aa sequence identity lower than 80% with its closest relative, the RdRp of the putative alphapartitivirus Grapevine partitivirus, and lower than 60% with the RdRps of other partitiviruses. In a phylogenetic tree constructed with RdRp aa sequences of selected partitiviruses, the putative virus EpV1 clustered with Grapevine partitivirus and formed a well-supported monophyletic clade with known or putative alphapartitiviruses.

  13. Putative role of Tat-Env interaction in HIV infection.

    Science.gov (United States)

    Poon, Selina; Moscoso, Carlos G; Xing, Li; Kan, Elaine; Sun, Yide; Kolatkar, Prasanna R; Vahlne, Anders G; Srivastava, Indresh K; Barnett, Susan W; Cheng, R Holland

    2013-09-24

    To study the complex formed between Tat protein and Env soluble trimeric immunogen, and compare with previously determined structures of Env native trimers and Env-CD4m complexes. The soluble Env trimer was used to mimic the spike glycoprotein on the virus surface for the study. To overcome limitations of other structural determination methods, cryoelectron microscopy was employed to image the complex, and single particle reconstruction was utilized to reconstruct the structure of the complex from collected micrographs. Molecular modeling of gp120-Tat was performed to provide atomic coordinates for docking. Images were preprocessed by multivariate statistical analysis to identify principal components of variation then submitted for reconstruction. Reconstructed structures were docked with modeled gp120-Tat atomic coordinates to study the positions of crucial epitopes. Analysis of the Env-Tat complex demonstrated an intermediate structure between Env native trimers and Env-CD4m structures. Docking results indicate that the CD4-binding site and the V3 loop are exposed in the Env-Tat complex. The integrin-binding sequence in Tat was also exposed in Env-Tat docking. The intermediate structure induced by Tat-interaction with Env could potentially provide an explanation for increased virus infection in the presence of Tat protein. Consequently, exposure of CD4-binding sites and a putative integrin-binding sequence on Tat in the complex may provide a new avenue for rational design of an effective HIV vaccine. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins

  14. A new putative sigma factor of Myxococcus xanthus.

    Science.gov (United States)

    Apelian, D; Inouye, S

    1993-06-01

    A third putative sigma factor gene, sigC, has been isolated from Myxococcus xanthus by using the sigA gene (formerly rpoD of M. xanthus) as a probe. The nucleotide sequence of sigC has been determined, and an open reading frame of 295 residues (M(r) = 33,430) has been identified. The deduced amino acid sequence of sigC exhibits the features which are characteristic of other bacterial sigma factors. The characterization of a sigC-lacZ strain has demonstrated that sigC expression is induced immediately after cells enter into the developmental cycle and is dramatically reduced at the onset of sporulation. A deletion mutant of sigC grows normally in vegetative culture and is able to develop normally. However, in contrast to the wild-type cells, the sigC deletion mutant cells became capable of forming fruiting bodies and myxospores on semirich agar plates. This suggests that sigC may play a role in expression of genes involved in negatively regulating the initiation of fruiting body formation.

  15. Mobile Agents

    Science.gov (United States)

    Satoh, Ichiro

    Mobile agents are autonomous programs that can travel from computer to computer in a network, at times and to places of their own choosing. The state of the running program is saved, by being transmitted to the destination. The program is resumed at the destination continuing its processing with the saved state. They can provide a convenient, efficient, and robust framework for implementing distributed applications and smart environments for several reasons, including improvements to the latency and bandwidth of client-server applications and reducing vulnerability to network disconnection. In fact, mobile agents have several advantages in the development of various services in smart environments in addition to distributed applications.

  16. Mobile Usability

    DEFF Research Database (Denmark)

    Aryana, Bijan; Clemmensen, Torkil

    2013-01-01

    In this article, a country specific comparative mobile usability study is presented, using Iran and Turkey as the two chosen emerging/emergent nation exemplars of smartphone usage and adoption. In a focus group study, three mobile applications were selected by first-time users of smartphones....... In both countries, the music player application was tested, wherein common patterns of accessing and sorting songs emerged. Whereas the Iranian users appeared to be more interested in social networking via use of an SMS service, the Turkish users tended to prefer to apply hierarchies to their own daily...

  17. Within-genome evolution of REPINs: a new family of miniature mobile DNA in bacteria.

    Directory of Open Access Journals (Sweden)

    Frederic Bertels

    2011-06-01

    Full Text Available Repetitive sequences are a conserved feature of many bacterial genomes. While first reported almost thirty years ago, and frequently exploited for genotyping purposes, little is known about their origin, maintenance, or processes affecting the dynamics of within-genome evolution. Here, beginning with analysis of the diversity and abundance of short oligonucleotide sequences in the genome of Pseudomonas fluorescens SBW25, we show that over-represented short sequences define three distinct groups (GI, GII, and GIII of repetitive extragenic palindromic (REP sequences. Patterns of REP distribution suggest that closely linked REP sequences form a functional replicative unit: REP doublets are over-represented, randomly distributed in extragenic space, and more highly conserved than singlets. In addition, doublets are organized as inverted repeats, which together with intervening spacer sequences are predicted to form hairpin structures in ssDNA or mRNA. We refer to these newly defined entities as REPINs (REP doublets forming hairpins and identify short reads from population sequencing that reveal putative transposition intermediates. The proximal relationship between GI, GII, and GIII REPINs and specific REP-associated tyrosine transposases (RAYTs, combined with features of the putative transposition intermediate, suggests a mechanism for within-genome dissemination. Analysis of the distribution of REPs in a range of RAYT-containing bacterial genomes, including Escherichia coli K-12 and Nostoc punctiforme, show that REPINs are a widely distributed, but hitherto unrecognized, family of miniature non-autonomous mobile DNA.

  18. HinT proteins and their putative interaction partners in Mollicutes and Chlamydiaceae

    Directory of Open Access Journals (Sweden)

    Hegemann Johannes H

    2005-05-01

    Full Text Available Background HinT proteins are found in prokaryotes and eukaryotes and belong to the superfamily of HIT proteins, which are characterized by an histidine-triad sequence motif. While the eukaryotic variants hydrolyze AMP derivates and modulate transcription, the function of prokaryotic HinT proteins is less clearly defined. In Mycoplasma hominis, HinT is concomitantly expressed with the proteins P60 and P80, two domains of a surface exposed membrane complex, and in addition interacts with the P80 moiety. Results An cluster of hitABL genes, similar to that of M. hominis was found in M. pulmonis, M. mycoides subspecies mycoides SC, M. mobile and Mesoplasma florum. RT-PCR analyses provided evidence that the P80, P60 and HinT homologues of M. pulmonis were polycistronically organized, suggesting a genetic and physical interaction between the proteins encoded by these genes in these species. While the hit loci of M. pneumoniae and M. genitalium encoded, in addition to HinT, a protein with several transmembrane segments, the hit locus of Ureaplasma parvum encoded a pore-forming protein, UU270, a P60 homologue, UU271, HinT, UU272, and a membrane protein of unknown function, UU273. Although a full-length mRNA spanning the four genes was not detected, amplification of all intergenic regions from the center of UU270 to the end of UU273 by RT-PCR may be indicative of a common, but unstable mRNA. In Chlamydiaceae the hit gene is flanked upstream by a gene predicted to encode a metal dependent hydrolase and downstream by a gene putatively encoding a protein with ARM-repeats, which are known to be involved in protein-protein interactions. In RT-PCR analyses of C. pneumoniae, regions comprising only two genes, Cp265/Cp266 and Cp266/Cp267 were able to be amplified. In contrast to this in vivo interaction analysis using the yeast two-hybrid system and in vitro immune co-precipitation revealed an interaction between Cp267, which contains the ARM repeats, Cp265, the

  19. Sustainable Mobility

    DEFF Research Database (Denmark)

    Kjærulff, Aslak Aamot

    This paper combines strands of mobilities theory and planning theory, and develops a qualitative approach to look across emerging planning practices. By actively following 8 Danish urban and transport planners, over the course of 2 years, we learn how their practices have changed, inspired...

  20. Mobile Phone

    Institute of Scientific and Technical Information of China (English)

    籍万杰

    2004-01-01

    Your mobile phone rings.and instead of usual electronic signals,it's playing your favorite music.A friend sends your favorite song to cheer you up.One day,a record company might forward new records and music videos to your phone.

  1. Mobil nationalisme

    DEFF Research Database (Denmark)

    Koefoed, Lasse Martin

    2006-01-01

    , varer, mennesker og kapital men derimod en integreret del af disse tendenser. Gennem begrebet mobil nationalisme argumenteres der for en analytisk optik, hvor nationalisme forstås som en proces hvorigennem skiftende relationer og bevægelser mellem forskellige socio-rumlige skalaer som kroppen...

  2. Mobile IP

    NARCIS (Netherlands)

    Heijenk, Geert; Sallent, S.; Pras, A.

    1999-01-01

    The Internet is growing exponentially, both in the amount of traffic carried, and in the amount of hosts connected. IP technology is becoming more and more important, in company networks (Intranets), and also in the core networks for the next generation mobile networks. Further, wireless access to I

  3. Sustainable Mobility

    DEFF Research Database (Denmark)

    Kjærulff, Aslak Aamot

    This paper combines strands of mobilities theory and planning theory, and develops a qualitative approach to look across emerging planning practices. By actively following 8 Danish urban and transport planners, over the course of 2 years, we learn how their practices have changed, inspired...

  4. Mobile IP

    NARCIS (Netherlands)

    Heijenk, Gerhard J.; Sallent, S.; Pras, Aiko

    1999-01-01

    The Internet is growing exponentially, both in the amount of traffic carried, and in the amount of hosts connected. IP technology is becoming more and more important, in company networks (Intranets), and also in the core networks for the next generation mobile networks. Further, wireless access to

  5. Mobile Misfortune

    DEFF Research Database (Denmark)

    Vigh, Henrik Erdman

    2015-01-01

    for themselves and their families, it shows how involvement in the cocaine trade is both a curse and a catalyst. Though trading the drug may facilitate migration and mobility, generating social being and worth in the process, it is an activity that is haunted by the threat of deportation and the termination...

  6. Spatiotemporal features of human mobility

    CERN Document Server

    Bagrow, James P

    2012-01-01

    The individual movements of large numbers of people are important in many contexts, from urban planning to disease spreading. Datasets that capture human mobility are now available and many interesting features have been discovered, including the ultra-slow spatial growth of individual mobility. However, the detailed substructures and spatiotemporal flows of mobility-the sets and sequences of visited locations-have not been well studied. We show that individual mobility is dominated by small groups of frequently visited, dynamically close locations, forming primary "habitats" capturing typical daily activity, along with subsidiary habitats representing additional travel. These habitats do not correspond to typical contexts such as home or work. The temporal evolution of mobility within habitats, which constitutes most motion, is universal across habitats and exhibits scaling patterns both distinct from all previous observations and unpredicted by current models. The delay to enter subsidiary habitats is a pri...

  7. Putative Corneal Neuralgia Responding to Vitamin D Supplementation

    Directory of Open Access Journals (Sweden)

    Eric L. Singman

    2013-09-01

    Full Text Available A patient with putative corneal neuralgia was incidentally discovered to have hypovitaminosis D. Supplementation of vitamin D appears to have led to a resolution of the patient's pain, whereas other efforts to treat the patient were unsuccessful.

  8. User Experience of Mobile Devices

    DEFF Research Database (Denmark)

    Raptis, Dimitrios

    , and it continues with related work on usability, coolness and previous studies that investigated their relation to physical form. It then presents a research classification that guided my research work, where the papers are placed in relation to their research purpose: exploration and validation. Explorative......This thesis focuses on mobile devices and it specifically investigates the effect of their physical form on two perceived user experience qualities, usability and coolness. With the term mobile devices, I refer to interactive products that users interact with while being on the move......, and with the term physical form I refer to the physical elements that constitute a mobile device as a whole, such as weight, size and materials. The selected research area was addressed through two research questions, one focusing on effects of physical form on usability and the other on effects on coolness...

  9. The Ambiguous Attractiveness of Mobility

    DEFF Research Database (Denmark)

    Presskorn-Thygesen, Thomas

    2015-01-01

    ’ can help us understand the attractiveness of constantly being ‘on the move’. Qualitative data from three exemplars of this elite group of workers is used to illustrate how the ideal of being mobile is perceived as an often problematic imperative, but also as one which is nevertheless rewarding......This article examines the forms of mobility that characterize contemporary work life. In doing so, it applies the theoretical framework associated with Luc Boltanski’s sociology of critique (Boltanski, 2012 [1990]; Boltanski and Thévenot, 2006 [1991]) and argues that this framework offers...... a fruitful and important perspective in conceptualizing and understanding the forms of mobility that are becoming increasingly prevalent in today’s knowledge work. The sociology of critique allows one to chart the economic and historical conditions of mobility critically, while its sociology of morals also...

  10. Mobile Immersion: An Experiment Using Mobile Instant Messenger to Support Second-Language Learning

    Science.gov (United States)

    Lai, Arthur

    2016-01-01

    Immersion has been an acclaimed approach for second-language acquisition, but is not available to most students. The idea of this study was to create a mobile immersion environment on a smartphone using a mobile instant messenger, WhatsApp™. Forty-five Form-1 (7th grade) students divided into the Mobile Group and Control Group participated in a…

  11. Mobile Immersion: An Experiment Using Mobile Instant Messenger to Support Second-Language Learning

    Science.gov (United States)

    Lai, Arthur

    2016-01-01

    Immersion has been an acclaimed approach for second-language acquisition, but is not available to most students. The idea of this study was to create a mobile immersion environment on a smartphone using a mobile instant messenger, WhatsApp™. Forty-five Form-1 (7th grade) students divided into the Mobile Group and Control Group participated in a…

  12. The Models and Politics of Mobile Media

    Directory of Open Access Journals (Sweden)

    Gerard Goggin

    2008-01-01

    Full Text Available In this paper I seek to critically evaluate the models at play in an important area of new media cultures -- mobile media. By 'mobile', I mean the new technologies, cultural practices, and arrangements of production, consumption, and exchange, emerging with hand-held, networked devices --especially those based on mobile cellular networks. These mobile phone technologies are now commonly being framed as media; and so we see the appearance of objects such as mobile television, mobile film, mobile games, and mobile Internet. This much-heralded move, with its large cultural and commercial claims, raises important theoretical and political questions. To zero in on what it at stake in the shift from mobile phone to mobile media, I consider three distinct though related models that for ease of reference I will term: phones; commons; publics. Firstly, I look at the model of the telephone (latterly, telecommunications that is still strongly influential in the shaping of mobiles as they now figure as media. This is something that is not widely recognised, however -- for instance, when mobiles as simply seen as an extension of new media cultures based on ideas formed through the experience of the Internet. Secondly, I consider the model of the commons and what light it throws on the politics of mobile media. Discussions of the commons -- for instance, the lucid work of Yochai Benkler in his 2006 The Wealth of Networks -- typically take the Internet as their paradigm example. But what how does the model of commons relate to mobiles, and what might it tell us about mobile media? Thirdly, while the telephone and mobile phone also have often been modelled through the concept of 'community', mobile media encourage us to think about the different and sometimes opposed model of publics. In drawing upon recent work on publics, what I am interested here is how new kinds of publics are emerging with mobile media.

  13. Mobile-to-mobile wireless channels

    CERN Document Server

    Zajic, Alenka

    2013-01-01

    Present-day mobile communications systems can be classified as fixed-to-mobile because they allow mobility on only one end (e.g. the mobile phone to a fixed mobile operator's cell tower). In answer to the consumer demand for better coverage and quality of service, emerging mobile-to-mobile (M-to-M) communications systems allow mobile users or vehicles to directly communicate with each other. This practical book provides a detailed introduction to state-of-the-art M-to-M wireless propagation. Moreover, the book offers professionals guidance for rapid implementation of these communications syste

  14. The Ambiguous Attractiveness of Mobility

    DEFF Research Database (Denmark)

    Presskorn-Thygesen, Thomas

    2015-01-01

    allows us to explore the distinctly normative side of new forms of mobility without succumbing to a celebratory picture of work-related mobility. More specifically and in the context of the ‘kinetic elite’, the article explores how Boltanski and Chiapello’s (2005) analysis of a ‘projective order of worth......’ can help us understand the attractiveness of constantly being ‘on the move’. Qualitative data from three exemplars of this elite group of workers is used to illustrate how the ideal of being mobile is perceived as an often problematic imperative, but also as one which is nevertheless rewarding...... and worth living up to....

  15. Coalescence for Mobile Sensor Networks

    OpenAIRE

    Poduri, Sameera; Sukhatme, Gaurav S.

    2007-01-01

    Coalescence is the problem of isolated mobile robots independently searching for peers with the goal of forming a single connected network. This paper analyzes coalescence time for a worst-case scenario where the robots do not have any knowledge about the environment or positions of other robots and perform independent, memory less search. Using the random direction mobility model, we show that coalescence time has an exponential distribution which is a function of the number of robots, speed...

  16. Urban Mobility

    DEFF Research Database (Denmark)

    2017-01-01

    This anthology is the proceedings publication from the 2015 NAF Symposium in Malmö, Sweden. The aim of the 2015 NAF Symposium “Urban Mobility – Architectures, Geographies and Social Space” was to facilitate a cross-disciplinary discussion on urban mobility in which the juxtaposition of different...... discursive perceptions of the concept would foster greater insight into and understanding of both the challenges and potentials that it represents. It focused on some of the key themes currently facing cities and the urban: the transformation of the city and our built environment; migration; rural decline......; the interaction between city, architecture, and inhabitants; the role of architects and architecture in the creation of democratic and sustainable urban contexts; the city and its representation; the politics of intervention; and the actions of governing and developing. This proceedings publication from...

  17. A putative ABC transporter is involved in negative regulation of biofilm formation by Listeria monocytogenes

    DEFF Research Database (Denmark)

    Zhu, Xinna; Long, Fei; Chen, Yonghui

    2008-01-01

    Listeria monocytogenes may persist for long periods in food processing environments. In some instances, this may be due to aggregation or biofilm formation. To investigate the mechanism controlling biofilm formation in the food-borne pathogen L. monocytogenes, we characterized LM-49, a mutant...... with enhanced ability of biofilm-formation generated via transposon Tn917 mutagenesis of L. monocytogenes 4b G. In this mutant, a Tn917 insertion has disrupted the coding region of the gene encoding a putative ATP binding cassette (ABC) transporter permease identical to Lmof2365_1771 (a putative ABC......-transporter permease) presented in the sequenced strain L. monocytogenes str. 4b F2365. This disrupted gene, denoted lm.G_1771, encoded a protein with 10 transmembrane helixes. The revertant, LM-49RE, was obtained by replacing lm.G_1771::Tn917 with lm.G_1771 via homologous recombination. We found that LM-49RE formed...

  18. The solution structure of ChaB, a putative membrane ion antiporter regulator from Escherichia coli

    Directory of Open Access Journals (Sweden)

    Iannuzzi Pietro

    2004-08-01

    Full Text Available Abstract Background ChaB is a putative regulator of ChaA, a Na+/H+ antiporter that also has Ca+/H+ activity in E. coli. ChaB contains a conserved 60-residue region of unknown function found in other bacteria, archaeabacteria and a series of baculoviral proteins. As part of a structural genomics project, the structure of ChaB was elucidated by NMR spectroscopy. Results The structure of ChaB is composed of 3 α-helices and a small sheet that pack tightly to form a fold that is found in the cyclin-box family of proteins. Conclusion ChaB is distinguished from its putative DNA binding sequence homologues by a highly charged flexible loop region that has weak affinity to Mg2+ and Ca2+ divalent metal ions.

  19. Discussion on the Forms of and Problems in University Library 's Mobile Reading%论高校图书馆手机阅读的形式及存在的问题

    Institute of Scientific and Technical Information of China (English)

    倪俊蓉

    2015-01-01

    阐述了高校图书馆电子信息化的发展趋势,介绍了高校图书馆手机阅读模式应用概况,针对手机图书馆面临的问题,提出了相应对策.%This paper expounds the development trend of university library's electronic computerization, introduces the general situation of application of university library's mobile reading model, and in the light of the problems existing in mobile library, puts forward some corresponding countermeasures.

  20. Robotique Mobile

    OpenAIRE

    Filliat, David

    2011-01-01

    1 Introduction I Les bases de la navigation 2 Les différents types de navigation 3 Les sources d'information 4 Matériels courants en robotique mobile II Navigation réactive 5 Navigation vers un but 6 Évitement d'obstacles 7 Apprentissage par renforcement III Navigation utilisant une carte 8 Localisation, Cartographie et Planification 9 Les représentations de l'environne 10 Localisation 11 Cartographie 12 Planification; Engineering school

  1. The African Mobile Story

    DEFF Research Database (Denmark)

    This book identifies the factors that has enabled the growth of mobile telephony in Africa. The book covers the regulatory factors, the development and usage of mobile application, mobile security and sustainable power source for mobile networks......This book identifies the factors that has enabled the growth of mobile telephony in Africa. The book covers the regulatory factors, the development and usage of mobile application, mobile security and sustainable power source for mobile networks...

  2. The African Mobile Story

    DEFF Research Database (Denmark)

    This book identifies the factors that has enabled the growth of mobile telephony in Africa. The book covers the regulatory factors, the development and usage of mobile application, mobile security and sustainable power source for mobile networks......This book identifies the factors that has enabled the growth of mobile telephony in Africa. The book covers the regulatory factors, the development and usage of mobile application, mobile security and sustainable power source for mobile networks...

  3. Spectroscopy of Putative Brown Dwarfs in Taurus

    CERN Document Server

    Luhman, K L

    2010-01-01

    Quanz and coworkers have reported the discovery of the coolest known member of the Taurus star-forming complex (L2+/-0.5) and Barrado and coworkers have identified a possible protostellar binary brown dwarf in the same region. We have performed infrared spectroscopy on the former and the brighter component of the latter to verify their substellar nature. The resulting spectra do not exhibit the strong steam absorption bands that are expected for cool objects, demonstrating that they are not young brown dwarfs. The optical magnitudes and colors for these sources are also indicative of background stars rather than members of Taurus. Although the fainter component of the candidate protostellar binary lacks spectroscopy, we conclude that it is a galaxy rather than a substellar member of Taurus based on its colors and the constraints on its proper motion.

  4. Network Mobiles

    Directory of Open Access Journals (Sweden)

    Alhamali Masoud Alfrgani .Ali

    2015-07-01

    Full Text Available Mobile devices are becoming increasingly popular for delivering multimedia content, particularly by means of streaming. The main disadvantage of these devices is their limited battery life. Unfortunately, streaming of multimedia content causes the battery of the device to discharge very fast, often causing the battery to deplete before the streaming task finishes, resulting in user dissatisfaction. It is generally not possible to charge the device while on the go as electricity socket and charger are required. Therefore, to avoid this user dissatisfaction, it is necessary to find ways to prolong the battery lifetime and to support the completion of the multimedia streaming tasks. A typical architecture for mobile multimedia streaming is presented In this architecture, a wired server streams multimedia content over a wireless IP network to a number of client devices. These devices could be PDAs, smartphones or any other mobile device with 802.11 connectivity. In relation to possible power savings, the multimedia streaming process can be described as consisting of three stages: reception, decoding and playing. Other researchers have shown that energy savings can be made in each stage, for example by using pre-buffering in the reception stage, feedback control during decoding and backlight adjustment for playing. However, it is not a common practice to combine energy savings in the three stages in order to achieve the best

  5. Going mobile

    Science.gov (United States)

    Brus, Eric

    1987-12-01

    By 1990, all metropolitan areas in the U.S. and rural areas close to major cities or towns are expected to have cellular telephone service; 22 Canadian cities also feature cellular service. To supply mobile telecommunication services to sparsely-populated rural areas, a mobile satellite service (MSS) is now being developed. In this paper the projected possibilities of the MSS system are discussed, including a possibility that a piggyback-MSS payload be added to the GSTAR-4 satellite which is scheduled for a launch in 1988 or 1989; one in which some of the hardware from aborted direct-broadcast satellites would be used; and the possibility of building a new MSS satellite with large servicing capacity. Canada is planning to launch its own mobile satellite, MSAT, in the early 1990s. The MSS is expected to be 'generic', serving not only people on land but maritime and aeronautical users as well. It will also offer major benefits to truck and automobile drivers, making it possible for them to conduct business or to call for assistance from locations beyond the range of cellular systems.

  6. Performance Evaluation Analysis of Group Mobility in Mobile Ad Hoc Networks

    Science.gov (United States)

    Irshad, Ehtsham; Noshairwan, Wajahat; Shafiq, Muhammad; Khurram, Shahzada; Irshad, Azeem; Usman, Muhammad

    Mobility of nodes is an important issue in mobile adhoc networks (MANET). Nodes in MANET move from one network to another individually and in the form of group. In single node mobility scheme every node performs registration individually in new MANET whereas in group mobility scheme only one node in a group i.e group representative (GR) performs registration on behalf of all other nodes in the group and is assigned Care of Address (CoA). Internet protocol (IP) of all other nodes in the group remains same. Our simulated results prove that group mobility scheme reduces number of messages and consumes less time for registration of nodes as compared to single node mobility scheme. Thus network load is reduced in group mobility scheme. This research paper evaluates the performance of group mobility with single node mobility scheme. Test bed for this evaluation is based on Network Simulator 2 (NS-2) environment.

  7. Molecular diagnosis of putative Stargardt disease probands by exome sequencing

    Directory of Open Access Journals (Sweden)

    Strom Samuel P

    2012-08-01

    Full Text Available Abstract Background The commonest genetic form of juvenile or early adult onset macular degeneration is Stargardt Disease (STGD caused by recessive mutations in the gene ABCA4. However, high phenotypic and allelic heterogeneity and a small but non-trivial amount of locus heterogeneity currently impede conclusive molecular diagnosis in a significant proportion of cases. Methods We performed whole exome sequencing (WES of nine putative Stargardt Disease probands and searched for potentially disease-causing genetic variants in previously identified retinal or macular dystrophy genes. Follow-up dideoxy sequencing was performed for confirmation and to screen for mutations in an additional set of affected individuals lacking a definitive molecular diagnosis. Results Whole exome sequencing revealed seven likely disease-causing variants across four genes, providing a confident genetic diagnosis in six previously uncharacterized participants. We identified four previously missed mutations in ABCA4 across three individuals. Likely disease-causing mutations in RDS/PRPH2, ELOVL, and CRB1 were also identified. Conclusions Our findings highlight the enormous potential of whole exome sequencing in Stargardt Disease molecular diagnosis and research. WES adequately assayed all coding sequences and canonical splice sites of ABCA4 in this study. Additionally, WES enables the identification of disease-related alleles in other genes. This work highlights the importance of collecting parental genetic material for WES testing as the current knowledge of human genome variation limits the determination of causality between identified variants and disease. While larger sample sizes are required to establish the precision and accuracy of this type of testing, this study supports WES for inherited early onset macular degeneration disorders as an alternative to standard mutation screening techniques.

  8. 移动学习模式下测绘专业知识测试系统设计与实现%Design and Implementation of Surveying and Mapping Expertise Test System Under the Form of Mobile Learning

    Institute of Scientific and Technical Information of China (English)

    杨金玲; 曹先革; 梁欣; 刘江

    2015-01-01

    随着WIFI和智能移动终端的普及,移动学习正在快速地发展。本文主要介绍了智能移动终端上的测绘专业知识测试系统的总体设计和部分实体E-R图,从系统登录与注册模块、个人中心模块、教师编辑试题模块、编辑测试模块、学生自测模块、学生考试模块等方面阐述了测绘专业知识系统的设计与实现,弥补了测绘专业在移动学习应用上的短缺状况。%With the popularity of WIFI and intelligent mobile terminals, mobile learning is rapid developing.This paper describes the overall design and some entity’ s E-R diagram of Surveying and Mapping expertise test system based on intelligent mobile devices, and from the log in and registration module, individual center module, teacher edit questions module, edit the test module, students self-test module, test module and other aspects, describes the design and implementation of Surveying and Mapping expertise test system, and this makes up for shortages of surveying and mapping professional on mobile learning applications.

  9. Characterization of three putative xylulose 5-phosphate/fructose 6-phosphate phosphoketolases in the cyanobacterium Anabaena sp. PCC 7120.

    Science.gov (United States)

    Moriyama, Takashi; Tajima, Naoyuki; Sekine, Kohsuke; Sato, Naoki

    2015-01-01

    Xylulose 5-phosphate/fructose 6-phosphate phosphoketolase (Xfp) is a key enzyme in the central carbohydrate metabolism in heterofermentative bacteria, in which enzymatic property of Xfps is well characterized. This is not the case in other microbes. The cyanobacterium Anabaena sp. PCC 7120 possesses three putative genes encoding Xfp, all1483, all2567, and alr1850. We purified three putative Xfps as recombinant proteins. The results of gel filtration indicated that these proteins form homomultimer complex. All1483 and All2567 showed phosphoketolase activity, whereas Alr1850 did not show the activity. Kinetic analyses demonstrated that substrates, fructose 6-phosphate and inorganic phosphate, are cooperatively bound to enzymes positively and negatively, respectively.

  10. Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthase.

    Science.gov (United States)

    Piel, Jörn; Wen, Gaiping; Platzer, Matthias; Hui, Dequan

    2004-01-03

    Polyketides of the pederin group are highly potent antitumor compounds found in terrestrial beetles and marine sponges. Pederin is used by beetles of the genera Paederus and Paederidus as a chemical defense. We have recently identified a group of putative pederin biosynthesis genes and localized them to the genome of an as yet unculturable Pseudomonas sp. symbiont, the likely true pederin producer. However, this polyketide synthase cluster lacks several genes expected for pederin production. Here we report an additional polyketide synthase encoded on a separate region of the symbiont genome. It contains at least three novel catalytic domains that are predicted to be involved in pederin chain initiation and the formation of an unusual exomethylene bond. The region is bordered by mobility pseudogenes; this suggests that gene transposition led to the disjointed cluster organization. With this work, all putative pederin genes have been identified. Their heterologous expression in a culturable bacterium will provide important insights into how sustainable sources of invertebrate-derived drug candidates can be created.

  11. The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers.

    Science.gov (United States)

    Amiri, Mahdi; Diekmann, Lena; von Köckritz-Blickwede, Maren; Naim, Hassan Y

    2015-08-28

    Lactase-phlorizin hydrolase (LPH) is a membrane glycoprotein and the only β-galactosidase of the brush border membrane of the intestinal epithelium. Besides active transcription, expression of the active LPH requires different maturation steps of the polypeptide through the secretory pathway, including N- and O-glycosylation, dimerization and proteolytic cleavage steps. The inability to digest lactose due to insufficient lactase activity results in gastrointestinal symptoms known as lactose intolerance. In this review, we will concentrate on the structural and functional features of LPH protein and summarize the cellular and molecular mechanism required for its maturation and trafficking. Then, different types of lactose intolerance are discussed, and the molecular aspects of lactase persistence/non-persistence phenotypes are investigated. Finally, we will review the literature focusing on the lactase persistence/non-persistence populations as a comparative model in order to determine the protective or adverse effects of milk and dairy foods on the incidence of colorectal, ovarian and prostate cancers.

  12. Plant phloem sterol content: forms, putative functions, and implications for phloem-feeding insects

    Directory of Open Access Journals (Sweden)

    Spencer eBehmer

    2013-09-01

    Full Text Available All eukaryotes contain sterols, which serve as structural components in cell membranes, and as precursors for important hormones. Plant vegetative tissues are known to contain mixtures of sterols, but very little is known about the sterol composition of phloem. Plants are food for many animals, but plant-feeding arthropods (including phloem-feeding insets are unique among animals in that they have lost the ability to synthesize sterols, and must therefore acquire these essential nutrients from their food, or via endosymbionts. Our paper starts by providing a very brief overview of variation in plant sterol content, and how different sterols can affect insect herbivores, including those specializing on phloem. We then describe an experiment, where we bulk collected phloem sap exudate from bean and tobacco, and analyzed its sterol content. This approach revealed two significant observations concerning phloem sterols. First, the phloem exudate from each plant was found to contain sterols in three different fractions – free sterols, sterols conjugated to lipids (acylated, and sterols conjugated to carbohydrates (glycosylated. Second, for both plants, cholesterol was identified as the dominant sterol in each phloem exudate fraction; the remaining sterol in the fraction was a mixture of common phytosterols. We discuss our phloem exudate sterol profiles in a plant physiology/biochemistry context, and how it relates to the nutritional physiology/ecology of phloem-feeding insects. We close by proposing important next steps that will advance our knowledge concerning plant phloem sterol biology, and how phloem-sterol content might affect phloem-feeding insects.

  13. The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers

    Directory of Open Access Journals (Sweden)

    Mahdi Amiri

    2015-08-01

    Full Text Available Lactase-phlorizin hydrolase (LPH is a membrane glycoprotein and the only β-galactosidase of the brush border membrane of the intestinal epithelium. Besides active transcription, expression of the active LPH requires different maturation steps of the polypeptide through the secretory pathway, including N- and O-glycosylation, dimerization and proteolytic cleavage steps. The inability to digest lactose due to insufficient lactase activity results in gastrointestinal symptoms known as lactose intolerance. In this review, we will concentrate on the structural and functional features of LPH protein and summarize the cellular and molecular mechanism required for its maturation and trafficking. Then, different types of lactose intolerance are discussed, and the molecular aspects of lactase persistence/non-persistence phenotypes are investigated. Finally, we will review the literature focusing on the lactase persistence/non-persistence populations as a comparative model in order to determine the protective or adverse effects of milk and dairy foods on the incidence of colorectal, ovarian and prostate cancers.

  14. NETWORK MOBILITY SUPPORTED PROXY MOBILE IPV6

    Directory of Open Access Journals (Sweden)

    Ananthi Jebaseeli SamuelRaj

    2014-01-01

    Full Text Available Proxy Mobile IPV6 (PMIPV6 is a network-based mobility management protocol, designed to keep track of individual mobile node’s movement. So a mobile node can easily roam in PMIPV6 network without changing it’s IP address. Network Mobility-Basic Support Protocol (NEMO-BSP, based on MIPV6, is the protocol designed for mobility management of NEMO in MPIV6 network. But NEMO-BSP cannot be directly used in PMIPV6 due to differences in the underlying protocols. To make PMIPV6 as a complete mobility management protocol, functionality of PMIPV6 should be enhanced to support network mobility in PMIPV6. This work enhances functionality of PMIPV6 and NEMO-BSP protocols and proposes a new architecture called NEMO supported PMIPV6 that supports movement of mobile nodes as well as network mobility in PMIPV6 network.

  15. Mobile Biomass Pelletizing System

    Energy Technology Data Exchange (ETDEWEB)

    Thomas Mason

    2009-04-16

    This grant project examines multiple aspects of the pelletizing process to determine the feasibility of pelletizing biomass using a mobile form factor system. These aspects are: the automatic adjustment of the die height in a rotary-style pellet mill, the construction of the die head to allow the use of ceramic materials for extreme wear, integrating a heat exchanger network into the entire process from drying to cooling, the use of superheated steam for adjusting the moisture content to optimum, the economics of using diesel power to operate the system; a break-even analysis of estimated fixed operating costs vs. tons per hour capacity. Initial development work has created a viable mechanical model. The overall analysis of this model suggests that pelletizing can be economically done using a mobile platform.

  16. Mobile Autonomous Humanoid Assistant

    Science.gov (United States)

    Diftler, M. A.; Ambrose, R. O.; Tyree, K. S.; Goza, S. M.; Huber, E. L.

    2004-01-01

    A mobile autonomous humanoid robot is assisting human co-workers at the Johnson Space Center with tool handling tasks. This robot combines the upper body of the National Aeronautics and Space Administration (NASA)/Defense Advanced Research Projects Agency (DARPA) Robonaut system with a Segway(TradeMark) Robotic Mobility Platform yielding a dexterous, maneuverable humanoid perfect for aiding human co-workers in a range of environments. This system uses stereo vision to locate human team mates and tools and a navigation system that uses laser range and vision data to follow humans while avoiding obstacles. Tactile sensors provide information to grasping algorithms for efficient tool exchanges. The autonomous architecture utilizes these pre-programmed skills to form human assistant behaviors. The initial behavior demonstrates a robust capability to assist a human by acquiring a tool from a remotely located individual and then following the human in a cluttered environment with the tool for future use.

  17. An Application of Mobile Agent System in Network Management

    Institute of Scientific and Technical Information of China (English)

    YANGChen-xiang; DUJun-ping; YINYi-xin

    2004-01-01

    This paper describes an application of a reusable mobile agent system in network management. A mobile agent reusable system is constructed to realize a new method in forming mobile agent systems. By using this method, an agent can change its route dynamically without making any change to its specific behavior. By classifying mobile agents into two categories, the task agent can be reusable in different networks. In this way, a mobile agent system can easily carry out network management tasks.

  18. Social Mobilization.

    Science.gov (United States)

    Rogers, Todd; Goldstein, Noah J; Fox, Craig R

    2017-09-25

    This article reviews research from several behavioral disciplines to derive strategies for prompting people to perform behaviors that are individually costly and provide negligible individual or social benefits but are meaningful when performed by a large number of individuals. Whereas the term social influence encompasses all the ways in which people influence other people, social mobilization refers specifically to principles that can be used to influence a large number of individuals to participate in an activity. The motivational force of social mobilization is amplified by the fact that others benefit from the encouraged behaviors, and its overall impact is enhanced by the fact that people are embedded within social networks. This article may be useful to those interested in the provision of public goods, collective action, and prosocial behavior, and we give special attention to field experiments on election participation, environmentally sustainable behaviors, and charitable giving. Expected final online publication date for the Annual Review of Psychology Volume 69 is January 4, 2018. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

  19. Mobile Transporter

    Science.gov (United States)

    2001-01-01

    The Space Shuttle Atlantis, STS-110 mission, deployed this railcar, called the Mobile Transporter, and an initial 43-foot section of track, the S0 (S-zero) truss, preparing the International Space Station (ISS) for future spacewalks. The first railroad in space, the Mobile Transporter will allow the Station's robotic arm to travel up and down the finished truss for future assembly and maintenance. The 27,000-pound S0 truss is the first of 9 segments that will make up the Station's external framework that will eventually stretch 356 feet (109 meters), or approximately the length of a football field. The completed truss structure will hold solar arrays and radiators to provide power and cooling for additional international research laboratories from Japan and Europe that will be attached to the Station. The Space Shuttle Orbiter Atlantis, STS-110 mission, was launched April 8, 2002 and returned to Earth April 19, 2002. STS-110's Extravehicular Activity (EVA) marked the first use of the Station's robotic arm to maneuver spacewalkers around the Station.

  20. Mobile Misfortune

    Directory of Open Access Journals (Sweden)

    Henrik Vigh

    2015-06-01

    Full Text Available This article examines how the emergent cocaine trade in Bissau, the capital of the west African country of Guinea-Bissau, has become entangled with and trickled into the life worlds, hopes and fears of the city's many impoverished young men. The article is divided into two parts. While the first part looks at the predicament of youth and the hope of migration in Bissau, the second illuminates the anguish of deportation and the despair of being forcefully "displaced back home." Following in the footsteps of the young men that seek to navigate the cocaine trade, in order to obtain better lives for themselves and their families, it shows how involvement in the cocaine trade is both a curse and a catalyst. Though trading the drug may facilitate migration and mobility, generating social being and worth in the process, it is an activity that is haunted by the threat of deportation and the termination of the mobility it enables. This article, thus, looks at the motives and manners in which young men in Bissau become caught up in transnational flows of cocaine. It shows how motion is emotively anchored and affectively bound: tied to and directed toward a feeling of worth and realisation of being, and how migration from the global South often has negative potentiality as an end-point via the ascription of illegality and condition of deportability that shade it.

  1. Mobility Impact on Performance of Mobile Grids

    CERN Document Server

    Nandeppanavar, A S; Manvi, S S; Shridhar,

    2010-01-01

    Wireless mobile grids are one of the emerging grid types, which help to pool the resources of several willing and cooperative mobile devices to resolve a computationally intensive task. The mobile grids exhibit stronger challenges like mobility management of devices, providing transparent access to grid resources, task management and handling of limited resources so that resources are shared efficiently. Task execution on these devices should not be affected by their mobility. The proposed work presents performance evaluation of wireless mobile grid using normal walk mobility model. The normal walk model represents daily motion of users and the direction of motion is mostly symmetric in a real life environment, thus it is effective in location updating of a mobile station and in turn helps task distribution among these available mobile stations. Some of the performance parameters such as Task Execution Time, task failure rate, communication overhead on Brokering Server and Monitoring Cost are discussed.

  2. Playful Mobility Choices: Motivating informed mobility decision making by applying game mechanics

    Directory of Open Access Journals (Sweden)

    A. Millonig

    2014-10-01

    Full Text Available Motivating people to change their mobility behaviour patterns towards more sustainable forms of mobility is one of the major challenges regarding climate change and quality of life. Recently, an increasing amount of attempts to use gamification for triggering such behavioural changes can be observed. However, little is known about the actual impact of using game elements. This contribution describes a concept for systematically analysing the group-specific effects of different game mechanics on mobility decision processes (e.g. mode and route choice. Based on theoretical findings concerning player types and mobility styles we developed a framework for identifying effective game mechanics motivating users to explore mobility alternatives and take more informed and more sustainable mode or route choice decisions. The results will form the basis for implementing game mechanics in mobility information services motivating users to explore unfamiliar but more sustainable mobility options.

  3. Mobile video with mobile IPv6

    CERN Document Server

    Minoli, Daniel

    2012-01-01

    Increased reliance on mobile devices and streaming of video content are two of the most recent changes that have led those in the video distribution industry to be concerned about the shifting or erosion of traditional advertising revenues. Infrastructure providers also need to position themselves to take advantage of these trends. Mobile Video with Mobile IPv6provides an overview of the current mobile landscape, then delves specifically into the capabilities and operational details of IPv6. The book also addresses 3G and 4G services, the application of Mobile IPv6 to streaming and other mobil

  4. An Investigation of Mobile Learning Readiness in Higher Education Based on the Theory of Planned Behavior

    Science.gov (United States)

    Cheon, Jongpil; Lee, Sangno; Crooks, Steven M.; Song, Jaeki

    2012-01-01

    This study investigated the current state of college students' perceptions toward mobile learning in higher education. Mobile learning is a new form of learning utilizing the unique capabilities of mobile devices. Although mobile devices are ubiquitous on college campuses, student readiness for mobile learning has yet to be fully explored in the…

  5. An Investigation of Mobile Learning Readiness in Higher Education Based on the Theory of Planned Behavior

    Science.gov (United States)

    Cheon, Jongpil; Lee, Sangno; Crooks, Steven M.; Song, Jaeki

    2012-01-01

    This study investigated the current state of college students' perceptions toward mobile learning in higher education. Mobile learning is a new form of learning utilizing the unique capabilities of mobile devices. Although mobile devices are ubiquitous on college campuses, student readiness for mobile learning has yet to be fully explored in the…

  6. A putative viral defence mechanism in archaeal cells

    DEFF Research Database (Denmark)

    Lillestøl, Reidun K; Redder, Peter; Garrett, Roger Antony

    2006-01-01

    in cells, and that both the mode of inhibition of viral propagation and the mechanism of adding spacer-repeat units to clusters, are dependent on RNAs transcribed from the clusters. Moreover, the putative inhibitory apparatus (piRNA-based) may be evolutionarily related to the interference RNA systems (si...

  7. Putative Lineage of Novel African Usutu Virus, Central Europe

    Centers for Disease Control (CDC) Podcasts

    2015-10-15

    Sarah Gregory reads an abridged version of "Putative Lineage of Novel African Usutu Virus, Central Europe.".  Created: 10/15/2015 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 10/15/2015.

  8. Putative golden proportions as predictors of facial esthetics in adolescents.

    NARCIS (Netherlands)

    Kiekens, R.M.A.; Kuijpers-Jagtman, A.M.; Hof, M.A. van 't; Hof, BE van 't; Maltha, J.C.

    2008-01-01

    INTRODUCTION: In orthodontics, facial esthetics is assumed to be related to golden proportions apparent in the ideal human face. The aim of the study was to analyze the putative relationship between facial esthetics and golden proportions in white adolescents. METHODS: Seventy-six adult laypeople

  9. Dynamics of putative raft-associated proteins at the cell surface.

    Science.gov (United States)

    Kenworthy, Anne K; Nichols, Benjamin J; Remmert, Catha L; Hendrix, Glenn M; Kumar, Mukesh; Zimmerberg, Joshua; Lippincott-Schwartz, Jennifer

    2004-06-07

    Lipid rafts are conceptualized as membrane microdomains enriched in cholesterol and glycosphingolipid that serve as platforms for protein segregation and signaling. The properties of these domains in vivo are unclear. Here, we use fluorescence recovery after photobleaching to test if raft association affects a protein's ability to laterally diffuse large distances across the cell surface. The diffusion coefficients (D) of several types of putative raft and nonraft proteins were systematically measured under steady-state conditions and in response to raft perturbations. Raft proteins diffused freely over large distances (> 4 microm), exhibiting Ds that varied 10-fold. This finding indicates that raft proteins do not undergo long-range diffusion as part of discrete, stable raft domains. Perturbations reported to affect lipid rafts in model membrane systems or by biochemical fractionation (cholesterol depletion, decreased temperature, and cholesterol loading) had similar effects on the diffusional mobility of raft and nonraft proteins. Thus, raft association is not the dominant factor in determining long-range protein mobility at the cell surface.

  10. Amplification of tumor inducing putative cancer stem cells (CSCs) by vitamin A/retinol from mammary tumors

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, Rohit B. [Department of Microbiology and Molecular Genetics, University of Pittsburgh, PA 15261 (United States); Wang, Qingde [Department of Surgery, University of Pittsburgh, PA 15261 (United States); Khillan, Jaspal S., E-mail: khillan@pitt.edu [Department of Microbiology and Molecular Genetics, University of Pittsburgh, PA 15261 (United States)

    2013-07-12

    Highlights: •Vitamin A supports self renewal of putative CSCs from mammary tumors. •These cells exhibit impaired retinol metabolism into retinoic acid. •CSCs from mammary tumors differentiate into mammary specific cell lineages. •The cells express mammary stem cell specific CD29 and CD49f markers. •Putative CSCs form highly metastatic tumors in NOD SCID mouse. -- Abstract: Solid tumors contain a rare population of cancer stem cells (CSCs) that are responsible for relapse and metastasis. The existence of CSC however, remains highly controversial issue. Here we present the evidence for putative CSCs from mammary tumors amplified by vitamin A/retinol signaling. The cells exhibit mammary stem cell specific CD29{sup hi}/CD49f{sup hi}/CD24{sup hi} markers, resistance to radiation and chemo therapeutic agents and form highly metastatic tumors in NOD/SCID mice. The cells exhibit indefinite self renewal as cell lines. Furthermore, the cells exhibit impaired retinol metabolism and do not express enzymes that metabolize retinol into retinoic acid. Vitamin A/retinol also amplified putative CSCs from breast cancer cell lines that form highly aggressive tumors in NOD SCID mice. The studies suggest that high purity putative CSCs can be isolated from solid tumors to establish patient specific cell lines for personalized therapeutics for pre-clinical translational applications. Characterization of CSCs will allow understanding of basic cellular and molecular pathways that are deregulated, mechanisms of tumor metastasis and evasion of therapies that has direct clinical relevance.

  11. A Mobile Application Prototype using Network Coding

    DEFF Research Database (Denmark)

    Pedersen, Morten Videbæk; Heide, Janus; Fitzek, Frank

    2010-01-01

    This paper looks into implementation details of network coding for a mobile application running on commercial mobile phones. We describe the necessary coding operations and algorithms that implements them. The coding algorithms forms the basis for a implementation in C++ and Symbian C++. We report...

  12. MOBILITY: A SYSTEMS APPROACH

    Directory of Open Access Journals (Sweden)

    Mykola I. Striuk

    2015-10-01

    Full Text Available A comprehensive study on the problem of mobility in the socio-educational and technical systems was carried out: the evolution of the concept of mobility in scientific sources of XIX–XXI centuries was analyzed and the new sources on the issue of mobility introduced into scientific circulation, the interrelation of the types of mobility in the socio-pedagogical and technical systems are theoretically grounded, an integrative model of mobility in the information society is proposed. The major trends in academic mobility are identified (the transition from student mobility to mobility programs and educational services providers, the new mobility programs (franchising, double/joint degrees, combinations, nostrification etc. are characterized. The new types of mobility providers are reviewed and attention is focused on virtual universities that are now the basis of virtual mobility of students and activities which are based on the use of new ICT in higher education, especially – the Internet and mobile learning environments.

  13. Mobile Inquiry Based Learning

    NARCIS (Netherlands)

    Specht, Marcus

    2012-01-01

    Specht, M. (2012, 8 November). Mobile Inquiry Based Learning. Presentation given at the Workshop "Mobile inquiry-based learning" at the Mobile Learning Day 2012 at the Fernuniversität Hagen, Hagen, Germany.

  14. Mobile Inquiry Based Learning

    NARCIS (Netherlands)

    Specht, Marcus

    2012-01-01

    Specht, M. (2012, 8 November). Mobile Inquiry Based Learning. Presentation given at the Workshop "Mobile inquiry-based learning" at the Mobile Learning Day 2012 at the Fernuniversität Hagen, Hagen, Germany.

  15. Cooperating mobile robots

    Energy Technology Data Exchange (ETDEWEB)

    Harrington, John J.; Eskridge, Steven E.; Hurtado, John E.; Byrne, Raymond H.

    2004-02-03

    A miniature mobile robot provides a relatively inexpensive mobile robot. A mobile robot for searching an area provides a way for multiple mobile robots in cooperating teams. A robotic system with a team of mobile robots communicating information among each other provides a way to locate a source in cooperation. A mobile robot with a sensor, a communication system, and a processor, provides a way to execute a strategy for searching an area.

  16. Trends in Mobile Marketing

    OpenAIRE

    Chocholová, Petra

    2010-01-01

    The principal aim of this thesis is to assess the state of the mobile marketing as of the first quarter of 2011 and to discuss various scenarios of the future development. This thesis defines the terms "mobile marketing" and "mobile advertising" and identifies the main players in the industry. It explores the main categories of mobile advertising such as mobile messaging, in-content and mobile internet advertising. Later, it analyzes the latest trends in the industry and describes in detail t...

  17. The molecular dimension of microbial species: 1. Ecological distinctions among, and homogeneity within, putative ecotypes of Synechococcus inhabiting the cyanobacterial mat of Mushroom Spring, Yellowstone National Park

    Directory of Open Access Journals (Sweden)

    Eric Daniel Becraft

    2015-06-01

    Full Text Available Based on the Stable Ecotype Model, evolution leads to the divergence of ecologically distinct populations (e.g., with different niches and/or behaviors of ecologically interchangeable membership. In this study, pyrosequencing was used to provide deep sequence coverage of Synechococcus psaA genes and transcripts over a large number of habitat types in the Mushroom Spring microbial mat. Putative ecological species (putative ecotypes, which were predicted by an evolutionary simulation based on the Stable Ecotype Model (Ecotype Simulation, exhibited distinct distributions relative to temperature-defined positions in the effluent channel and vertical position in the upper 1 mm-thick mat layer. Importantly, in most cases variants predicted to belong to the same putative ecotype formed unique clusters relative to temperature and depth in the mat in canonical correspondence analysis, supporting the hypothesis that while the putative ecotypes are ecologically distinct, the members of each ecotype are ecologically homogeneous. Putative ecotypes responded differently to experimental perturbations of temperature and light, but the genetic variation within each putative ecotype was maintained as the relative abundances of putative ecotypes changed, further indicating that each population responded as a set of ecologically interchangeable individuals. Compared to putative ecotypes that predominate deeper within the mat photic zone, the timing of transcript abundances for selected genes differed for putative ecotypes that predominate in microenvironments closer to upper surface of the mat with spatiotemporal differences in light and O2 concentration. All of these findings are consistent with the hypotheses that Synechococcus species in hot spring mats are sets of ecologically interchangeable individuals that are differently adapted, that these adaptations control their distributions, and that the resulting distributions constrain the activities of the species

  18. Mobile Schools for a Mobile World

    Science.gov (United States)

    Booth, Susan

    2013-01-01

    Overwhelmingly, independent schools are embracing mobile devices--laptops, iPads or other tablets, and smartphones--to enhance teaching and learning. This article describes the results of the "NAIS 2012 Mobile Learning Survey." Among its findings were that 75 percent of NAIS-member schools currently use mobile learning devices in at…

  19. Proceedings of the Mobile Satellite Conference

    Science.gov (United States)

    Rafferty, William

    1988-01-01

    A satellite-based mobile communications system provides voice and data communications to mobile users over a vast geographic area. The technical and service characteristics of mobile satellite systems (MSSs) are presented and form an in-depth view of the current MSS status at the system and subsystem levels. Major emphasis is placed on developments, current and future, in the following critical MSS technology areas: vehicle antennas, networking, modulation and coding, speech compression, channel characterization, space segment technology and MSS experiments. Also, the mobile satellite communications needs of government agencies are addressed, as is the MSS potential to fulfill them.

  20. Mobility management in LTE heterogeneous networks

    CERN Document Server

    Karandikar, Abhay; Mehta, Mahima

    2017-01-01

    This book is the first of its kind, compiling information on the Long-Term Evolution (LTE) standards, which are enhanced to address new mobility-related challenges in Heterogeneous Networks (HetNets). It identifies the related challenges and discusses solutions and the simulation methodology for modeling HetNet mobility – cutting-edge information that was previously accessible only in the form of 3GPP specifications and documents, and research papers. The book reviews the current LTE mobility framework and discusses some of the changes for enhancing mobility management in HetNets. It describes the measurement procedures, handover (HO) mechanisms and HO success/failure scenarios. HetNets are intended to provide very high spectral efficiency while ensuring seamless coverage by deploying low-power nodes within the umbrella macrocell network. While mobility management in homogeneous networks is well understood, LTE standards are being enhanced to address the HetNet-specific mobility management challenges emergi...

  1. Putative melatonin receptors in a human biological clock

    Energy Technology Data Exchange (ETDEWEB)

    Reppert, S.M.; Weaver, D.R.; Rivkees, S.A.; Stopa, E.G.

    1988-10-07

    In vitro autoradiography with /sup 125/I-labeled melatonin was used to examine melatonin binding sites in human hypothalamus. Specific /sup 125/I-labeled melatonin binding was localized to the suprachiasmatic nuclei, the site of a putative biological clock, and was not apparent in other hypothalamic regions. Specific /sup 125/I-labeled melatonin binding was consistently found in the suprachiasmatic nuclei of hypothalami from adults and fetuses. Densitometric analysis of competition experiments with varying concentrations of melatonin showed monophasic competition curves, with comparable half-maximal inhibition values for the suprachiasmatic nuclei of adults (150 picomolar) and fetuses (110 picomolar). Micromolar concentrations of the melatonin agonist 6-chloromelatonin completely inhibited specific /sup 125/I-labeled melatonin binding, whereas the same concentrations of serotonin and norepinephrine caused only a partial reduction in specific binding. The results suggest that putative melatonin receptors are located in a human biological clock.

  2. Trypanosoma brucei: a putative RNA polymerase II promoter.

    Science.gov (United States)

    Bayele, Henry K

    2009-12-01

    RNA polymerase II (pol II) promoters are rare in the African trypanosome Trypanosoma brucei because gene regulation in the parasite is complex and polycistronic. Here, we describe a putative pol II promoter and its structure-function relationship. The promoter has features of an archetypal eukaryotic pol II promoter including putative canonical CCAAT and TATA boxes, and an initiator element. However, the spatial arrangement of these elements is only similar to yeast pol II promoters. Deletion mapping and transcription assays enabled delineation of a minimal promoter that could drive orientation-independent reporter gene expression suggesting that it may be a bidirectional promoter. In vitro transcription in a heterologous nuclear extract revealed that the promoter can be recognized by the basal eukaryotic transcription complex. This suggests that the transcription machinery in the parasite may be very similar to those of other eukaryotes.

  3. Chromosomal Abnormalities and Putative Susceptibility Genes in Autism Spectrum Disorders

    DEFF Research Database (Denmark)

    Nielsen, Mette Gilling

    Autism spectrum disorders (ASDs) is a heterogeneous group of neurodevelopmental disorders with a significant genetic component as shown by family and twin studies. However, only a few genes have repeatedly been shown to be involved in the development of ASDs. The aim of this study has been...... to identify possible ASD susceptibility genes. Genome screens in ASD patients suggest possible susceptibility gene regions on almost every chromosome. We identified four ASD patients with chromosomal rearrangements, two of which were familial rearrangements involving one of these putative susceptibility gene......) was performed for all four patients. By combination of these methods we identified several putative susceptibility genes for ASDs. Expression patterns were established for several of these genes by Quantitative PCR (Q-PCR) or in situ hybridization and one gene was sequenced in 157 ASD patients. Our results...

  4. Cloning of partial putative gonadotropin hormone receptor sequence from fish

    Indian Academy of Sciences (India)

    G Kumaresan; T Venugopal; A Vikas; T J Pandian; S M Athavan

    2000-03-01

    A search for the presence of mariner-like elements in the Labeo rohita genome by polymerase chain reaction led to the amplification of a partial DNA sequence coding for a putative transmembrane domain of gonadotropin hormone receptor. The amplified DNA sequence shows a high degree of homology to the available turkey and human luteinizing and follicle stimulating hormone receptor coding sequences. This is the first report on cloning such sequences of piscine origin.

  5. A putative role for apelin in the etiology of obesity.

    Science.gov (United States)

    Rayalam, Srujana; Della-Fera, Mary Anne; Krieg, Paul A; Cox, Christopher M; Robins, Allan; Baile, Clifton A

    2008-04-11

    Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.

  6. TYPOLOGIES OF MOBILE APPLICATIONS

    OpenAIRE

    Ion Ivan; Alin Zamfiroiu; Dragoş Palaghiţă3

    2013-01-01

    Mobile applications and their particularities are analyzed. Mobile application specific characteristics are defined. Types of applications are identified and analyzed. The paper established differences between mobile applications and mobile application categories. For each identified type the specific structures and development model are identified.

  7. Mobile Support For Logistics

    Science.gov (United States)

    2016-03-01

    mobile app . This would include all tablets and smartphones and be compatible with all mobile operating systems such as Android , iOS, BlackBerry, and... SMARTPHONE SENSORS ....................................................................12 H. DEPARTMENT OF DEFENSE MOBILE DEVICE STRATEGY...2014, p. 51. .................................................................................9 Figure 3. GCSS-MC Mobile App Architecture

  8. Machine learning techniques to identify putative genes involved in nitrogen catabolite repression in the yeast Saccharomyces cerevisiae

    Science.gov (United States)

    Kontos, Kevin; Godard, Patrice; André, Bruno; van Helden, Jacques; Bontempi, Gianluca

    2008-01-01

    Background Nitrogen is an essential nutrient for all life forms. Like most unicellular organisms, the yeast Saccharomyces cerevisiae transports and catabolizes good nitrogen sources in preference to poor ones. Nitrogen catabolite repression (NCR) refers to this selection mechanism. All known nitrogen catabolite pathways are regulated by four regulators. The ultimate goal is to infer the complete nitrogen catabolite pathways. Bioinformatics approaches offer the possibility to identify putative NCR genes and to discard uninteresting genes. Results We present a machine learning approach where the identification of putative NCR genes in the yeast Saccharomyces cerevisiae is formulated as a supervised two-class classification problem. Classifiers predict whether genes are NCR-sensitive or not from a large number of variables related to the GATA motif in the upstream non-coding sequences of the genes. The positive and negative training sets are composed of annotated NCR genes and manually-selected genes known to be insensitive to NCR, respectively. Different classifiers and variable selection methods are compared. We show that all classifiers make significant and biologically valid predictions by comparing these predictions to annotated and putative NCR genes, and by performing several negative controls. In particular, the inferred NCR genes significantly overlap with putative NCR genes identified in three genome-wide experimental and bioinformatics studies. Conclusion These results suggest that our approach can successfully identify potential NCR genes. Hence, the dimensionality of the problem of identifying all genes involved in NCR is drastically reduced. PMID:19091052

  9. PERSONAL AND PROFESSIONAL MOBILITY: THE CONJUGACY PROBLEM

    Directory of Open Access Journals (Sweden)

    Tamara B. Sergeeva

    2015-01-01

    Full Text Available RETRACTED ARTICLEThe purpose of the paper is to develop a theoretical model conjugation of personal and professional mobility on the high school teachers’ example. Specific research problems of the study are to analyze the correlation properties of the mobile identity and mobile professional; the possibilities of forming professional mobility of teachers in the absence or underdevelopment of personal preconditions for mobility; search the features that can compensate this deficiency.Methods. The study is based on a theoretical analysis of different methodological approaches to the description of the personal and professional mobility. Also there were used the results of non-formal interview which was aimed at identifying the characteristics of the mobile professional teacher of high school.Results and scientific novelty. The concepts of «personal mobility» and «professional mobility» are clarified. Personal mobility is defined in the work as an integrative personal qualities, based on the individual properties (activity, plasticity, flexibility, adaptability, high energy source and manifests itself in the behavior and activities of the entity in the form of commitment, independence, openness to new experience, creativity and motivation for self-development, speed decisionmaking. Professional mobility is interpreted as a strategy to adapt to the changing conditions of professional activity, which is a special case of the general personal life strategy.Psychological readiness for pedagogical activity is considered as a link between the personal and professional mobility. Nine types of teacher's professional mobility, emerging as a result of different levels of personal mobility combined with the severity of psychological readiness for pedagogical activity are described.Practical significance. The analysis of the conjugacy problem of personal and professional mobility creates an informational basis for prolonged work on the formation of

  10. Next generation mobile broadcasting

    CERN Document Server

    Gómez-Barquero, David

    2013-01-01

    Next Generation Mobile Broadcasting provides an overview of the past, present, and future of mobile multimedia broadcasting. The first part of the book-Mobile Broadcasting Worldwide-summarizes next-generation mobile broadcasting technologies currently available. This part covers the evolutions of the Japanese mobile broadcasting standard ISDB-T One-Seg, ISDB-Tmm and ISDB-TSB; the evolution of the South Korean T-DMB mobile broadcasting technology AT-DMB; the American mobile broadcasting standard ATSC-M/H; the Chinese broadcasting technologies DTMB and CMMB; second-generation digital terrestrial

  11. E-Commerce Mobile Marketing Model Resolving Users Acceptance Criteria

    Directory of Open Access Journals (Sweden)

    Veronica S. Moertini

    2012-12-01

    Full Text Available The growth of e-commerce and mobile services has been creating business opportunities. Among these,mobile marketing is predicted to be a new trend of marketing. As mobile devices are personal tools suchthat the services ought to be unique, in the last few years, researches have been conducted studies relatedto the user acceptance of mobile services and produced results. This research aims to develop a model ofmobile e-commerce mobile marketing system, in the form of computer-based information system (CBISthat addresses the recommendations or criteria formulated by researchers. In this paper, the criteriaformulated by researches are presented then each of the criteria is resolved and translated into mobileservices. A model of CBIS, which is an integration of a website and a mobile application, is designed tomaterialize the mobile services. The model is presented in the form of business model, system procedures,network topology, software model of the website and mobile application, and database models.

  12. Mobile platform security

    CERN Document Server

    Asokan, N; Dmitrienko, Alexandra

    2013-01-01

    Recently, mobile security has garnered considerable interest in both the research community and industry due to the popularity of smartphones. The current smartphone platforms are open systems that allow application development, also for malicious parties. To protect the mobile device, its user, and other mobile ecosystem stakeholders such as network operators, application execution is controlled by a platform security architecture. This book explores how such mobile platform security architectures work. We present a generic model for mobile platform security architectures: the model illustrat

  13. ON MOBILE MESH NETWORKS

    OpenAIRE

    2015-01-01

    With the advances in mobile computing technologies and the growth of the Net, mobile mesh networks are going through a set of important evolutionary steps. In this paper, we survey architectural aspects of mobile mesh networks and their use cases and deployment models. Also, we survey challenging areas of mobile mesh networks and describe our vision of promising mobile services. This paper presents a basic introductory material for Masters of Open Information Technologies Lab, interested in m...

  14. LTE mobile network technology

    OpenAIRE

    Sladič, Klemen

    2012-01-01

    The main purpose of this thesis is an introduction to long term evolution of fourth generation mobile networks based on LTE mobile network standard. Fourth generation mobile networks are currently one of the most developed technology in the world of mobile communications and are somewhere already available for commercial use. At the beginning is a short history of mobile networks evolution, for easier understanding. In the history you can find information from first researches of magnetic...

  15. MOBILE AGENT: EMERGING TECHNOLOGY

    OpenAIRE

    RAJGURU P. V. DR. DESHMUKH S. D

    2011-01-01

    Mobile agent technology has been promoted as an emerging technology that makes it much easier to design, implement, and maintain distributed systems, introduction to basic concepts of mobile agents like agent mobility, agent types and places and agent communication. Then benefits of the usage of mobile agents are summarized and illustrated by selected applications. The next section lists requirements and desirable properties for mobile agent languages and systems. We study the main features, ...

  16. Islamic Mobility

    DEFF Research Database (Denmark)

    Fischer, Johan

    2016-01-01

    assert themselves in modern Malaysia, the more the growing Malay Muslim middle class is split between desiring cars as positional commodities, on the one hand, and claims for piety through consumption, on the other. An important question is how Malay Muslim middle-class identity is practised through...... divergent forms of car consumption. Discussing ethnographic material from fieldwork among Malay middle-class families, I show how car consumption generates not only distinctions, practices and moral symbolic boundaries but also ideas about Islam, nation and excess....

  17. Upward social mobility and identity.

    Science.gov (United States)

    Destin, Mesmin; Debrosse, Régine

    2017-08-09

    As psychological research on socioeconomic status (SES) continues to expand, greater attention should be devoted to the influence of social mobility and the dynamic and malleable aspects of SES on people's lives. Status-based identity describes how people's socioeconomic circumstances relate to their broader sense of self and the meaning that they make of their own SES. Such an approach allows for complex study of the challenges and consequences of a change in SES. Research related to status-based identity suggests that although social mobility is often considered a signifier of reduced inequality, upward social mobility may also exacerbate other forms of inequality by instigating a destabilizing sense of status uncertainty that impairs motivation and well-being for class migrants. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Haemolytic and cytotoxic activities of the Tween 80-extracted putative haemolysin of Pasteurella multocida B:2.

    Science.gov (United States)

    Chachra, D; Coote, J G; Parton, R; Jand, S K

    2011-06-02

    The objective of this study was to investigate the haemolytic and cytotoxic activity of Pasteurella multocida B:2 strains, originally from cases of haemorrhagic septicaemia in cattle. All six P. multocida B:2 strains were non-haemolytic on sheep blood agar (SBA) and horse blood agar (HBA) when grown aerobically and on SBA anaerobically but they were haemolytic on HBA when grown anaerobically. No haemolytic activity against horse red blood cells was detected in culture supernates from aerobically or anaerobically grown cultures and only very weak haemolytic activity was obtained in supernates or pellet fractions from sonicated cells. However, after repeated extraction of sonicated cells with Tween 80, haemolytic activity was found in various cell fractions, both Tween-soluble and -insoluble. The Tween-extracted putative haemolysin and other bacterial fractions were also cytotoxic for mouse macrophage-like J774.2 cells. Further characterisation of the putative haemolysin revealed it to be a heat-labile, non-pore-forming protein of molecular weight >10 kDa whose activity was completely destroyed by trypsin and greatly reduced with protease and proteinase K treatment. Congo red also reduced the haemolytic activity. Non-denaturing gel-electrophoresis and RBC agar overlay revealed clear haemolytic zones but suggested that Tween was bound to some component of the P. multocida B:2 fractions and was responsible, to some extent, for the haemolytic activity observed. However, the effect of heat and other reagents on the Tween-extracted fractions and the lack of haemolytic activity in different Tween-extracted cell fractions of organisms other than P. multocida suggested that some proteinaceous component of the organism could indeed act as a haemolysin. This putative haemolysin may be one of the virulence attributes of P. multocida, but its characterisation and role in pathogenesis require further study.

  19. Identification and characterization of a gene encoding a putative lysophosphatidyl acyltransferase from Arachis hypogaea

    Indian Academy of Sciences (India)

    Si-Long Chen; Jia-Quan Huang; Lei Yong; Yue-Ting Zhang; Xiao-Ping Ren; Yu-Ning Chen; Hui-Fang Jiang; Li-Ying Yan; Yu-Rong Li; Bo-Shou Liao

    2012-12-01

    Lysophosphatidyl acyltransferase (LPAT) is the important enzyme responsible for the acylation of lysophosphatidic acid (LPA), leading to the generation of phosphatidic acid (PA) in plant. Its encoding gene is an essential candidate for oil crops to improve oil composition and increase seed oil content through genetic engineering. In this study, a full-length AhLPAT4 gene was isolated via cDNA library screening and rapid amplification of cDNA ends (RACE); our data demonstrated that AhLPAT4 had 1631 nucleotides, encoding a putative 43.8 kDa protein with 383 amino acid residues. The deduced protein included a conserved acyltransferase domain and four motifs (I–IV) with putative LPA and acyl-CoA catalytic and binding sites. Bioinformatic analysis indicated that AhLPAT4 contained four transmembrane domains (TMDs), localized to the endoplasmic reticulum (ER) membrane; detailed analysis indicated that motif I and motifs II–III in AhLPAT4 were separated by the third TMD, which located on cytosolic and ER luminal side respectively, and hydrophobic residues on the surface of AhLPAT4 protein fold to form a hydrophobic tunnel to accommodate the acyl chain. Subcellular localization analysis confirmed that AhLPAT4 was a cytoplasm protein. Phylogenetic analysis revealed that AhLPAT4 had a high homology (63.7–78.3%) with putative LPAT4 proteins from Glycine max, Arabidopsis thaliana and Ricinus communis. AhLPAT4 was ubiquitously expressed in diverse tissues except in flower, which is almost undetectable. The expression analysis in different developmental stages in peanut seeds indicated that AhLPAT4 did not coincide with oil accumulation.

  20. Identification of putative rhamnogalacturonan-II specific glycosyltransferases in Arabidopsis using a combination of bioinformatics approaches.

    Science.gov (United States)

    Voxeur, Aline; André, Aurélie; Breton, Christelle; Lerouge, Patrice

    2012-01-01

    Rhamnogalacturonan-II (RG-II) is a complex plant cell wall polysaccharide that is composed of an α(1,4)-linked homogalacturonan backbone substituted with four side chains. It exists in the cell wall in the form of a dimer that is cross-linked by a borate di-ester. Despite its highly complex structure, RG-II is evolutionarily conserved in the plant kingdom suggesting that this polymer has fundamental functions in the primary wall organisation. In this study, we have set up a bioinformatics strategy aimed at identifying putative glycosyltransferases (GTs) involved in RG-II biosynthesis. This strategy is based on the selection of candidate genes encoding type II membrane proteins that are tightly coexpressed in both rice and Arabidopsis with previously characterised genes encoding enzymes involved in the synthesis of RG-II and exhibiting an up-regulation upon isoxaben treatment. This study results in the final selection of 26 putative Arabidopsis GTs, including 10 sequences already classified in the CAZy database. Among these CAZy sequences, the screening protocol allowed the selection of α-galacturonosyltransferases involved in the synthesis of α4-GalA oligogalacturonides present in both homogalacturonans and RG-II, and two sialyltransferase-like sequences previously proposed to be involved in the transfer of Kdo and/or Dha on the pectic backbone of RG-II. In addition, 16 non-CAZy GT sequences were retrieved in the present study. Four of them exhibited a GT-A fold. The remaining sequences harbored a GT-B like fold and a fucosyltransferase signature. Based on homologies with glycosyltransferases of known functions, putative roles in the RG-II biosynthesis are proposed for some GT candidates.

  1. Does chronic exposure to mobile phones affect cognition?

    OpenAIRE

    Mohan, Mamta; Khaliq, Farah; Panwar, Aprajita; Vaney, Neelam

    2016-01-01

    Mobile phones form an integral part of our modern lifestyle. Following the drastic rise in mobile phone use in recent years, it has become important to study its potential public health impact. Amongst the various mobile phone health hazards, the most alarming is the possible effect on the brain. The aim of the present study was to explore whether chronic exposure to mobile phones affects cognition. Ninety subjects aged 17–25 years with normal hearing were recruited for the study and divided ...

  2. Charging of mobile services by mobile payment reference model

    OpenAIRE

    Pousttchi, Key; Wiedemann, Dietmar Georg

    2005-01-01

    The purpose of the paper is to analyze mobile payments in the mobile commerce scenario. Therefore, we first classify the mobile payment in the mobile commerce scenario by explaining general offer models, charging concepts, and intermediaries. Second, we describe the mobile payment reference model, especially, the mobile payment reference organization model and different mobile payment standard types. Finally, we conclude our findings.

  3. Abrechnung mobiler Dienste im Mobile-Payment-Referenzmodell

    OpenAIRE

    Pousttchi, Key; Wiedemann, Dietmar Georg

    2005-01-01

    The purpose of the paper is to analyze mobile payments in the mobile commerce scenario. Therefore, we first classify the mobile payment in the mobile commerce scenario by explaining general offer models, charging concepts, and intermediaries. Second, we describe the mobile payment reference model, especially, the mobile payment reference organization model and different mobile payment standard types. Finally, we conclude our findings.

  4. Abrechnung mobiler Dienste im Mobile-Payment-Referenzmodell

    OpenAIRE

    Pousttchi, Key; Wiedemann, Dietmar Georg

    2005-01-01

    The purpose of the paper is to analyze mobile payments in the mobile commerce scenario. Therefore, we first classify the mobile payment in the mobile commerce scenario by explaining general offer models, charging concepts, and intermediaries. Second, we describe the mobile payment reference model, especially, the mobile payment reference organization model and different mobile payment standard types. Finally, we conclude our findings.

  5. The dynamics of mobile promoters: Enhanced stability in promoter regions.

    Science.gov (United States)

    Rabbani, Mahnaz; Wahl, Lindi M

    2016-10-21

    Mobile promoters are emerging as a new class of mobile genetic elements, first identified by examining prokaryote genome sequences, and more recently confirmed by experimental observations in bacteria. Recent datasets have identified over 40,000 putative mobile promoters in sequenced prokaryote genomes, however only one-third of these are in regions of the genome directly upstream from coding sequences, that is, in promoter regions. The presence of many promoter sequences in non-promoter regions is unexplained. Here we develop a general mathematical model for the dynamics of mobile promoters, extending previous work to capture the dynamics both within and outside promoter regions. From this general model, we apply rigorous model selection techniques to identify which parameters are statistically justified in describing the available mobile promoter data, and find best-fit values of these parameters. Our results suggest that high rates of horizontal gene transfer maintain the population of mobile promoters in promoter regions, and that once established at these sites, mobile promoters are rarely lost, but are commonly copied to other genomic regions. In contrast, mobile promoter copies in non-promoter regions are more numerous and more volatile, experiencing substantially higher rates of duplication, loss and diversification.

  6. Mobility Charters and Manifestos

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    2010-01-01

    the ‘mobility turn’ that mobility is much more than movement from A to B. Seeing the cultural dimension as well as the underpinning power plays of normative mobility discourses opens up the reflection about imagined futures and imagined mobile subjects. Theoretically the paper bridges discourse studies......This paper explore a number of different cases of articulating notions of ‘correct’ mobility behavior and practice by looking into charters, manifestos and codes of mobility regulation. Within such discourses of ‘correct mobility’ more or less subtle expressions of power as well as normative...... and ethical positions on mobility prevail. Such ‘imagined correct mobility behavior’ are drawing on larger issues of societal change that need to be brought out in a critical analysis and discussion reflecting the attempts to control, design and orchestrate mobility patterns. The paper therefore argues within...

  7. Mobility Charters and Manifestos

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    2010-01-01

    and ethical positions on mobility prevail. Such ‘imagined correct mobility behavior’ are drawing on larger issues of societal change that need to be brought out in a critical analysis and discussion reflecting the attempts to control, design and orchestrate mobility patterns. The paper therefore argues within......This paper explore a number of different cases of articulating notions of ‘correct’ mobility behavior and practice by looking into charters, manifestos and codes of mobility regulation. Within such discourses of ‘correct mobility’ more or less subtle expressions of power as well as normative...... the ‘mobility turn’ that mobility is much more than movement from A to B. Seeing the cultural dimension as well as the underpinning power plays of normative mobility discourses opens up the reflection about imagined futures and imagined mobile subjects. Theoretically the paper bridges discourse studies...

  8. Children's velo-mobility

    DEFF Research Database (Denmark)

    Carstensen, Trine Agervig; Nielsen, Thomas Sick; Olafsson, Anton Stahl

    2014-01-01

    Sustainable mobilities play a dominate role in low carbon futures and cycling is an integral element. Children are heirs of transport cultures and crucial for future sustainable mobility. Moreover cycling is important for children’s independent mobility and geographical experience. Dominating app...... the paper inform a discussion of urban planning and transport policy measures important for stabilizing sustainable mobility.......Sustainable mobilities play a dominate role in low carbon futures and cycling is an integral element. Children are heirs of transport cultures and crucial for future sustainable mobility. Moreover cycling is important for children’s independent mobility and geographical experience. Dominating...... approaches in transport research, including cycling, understand travel behaviour individualistic and lack to grasp the relational complexities, which are inevitable when considering children’s mobilities. Furthermore has children’s cycling largely been studied as independent mobility and active school travel...

  9. Active Network Supports for Mobile IP

    Institute of Scientific and Technical Information of China (English)

    LU Yueming; QIAN Depei; XU Bin; WANG Lei

    2001-01-01

    The basic mobile IP protocol is difficult to implement on the traditional IP network and not flexible and efficient under certain conditions. For example, firewalls or boundary routers may drop packets sent by mobile nodes for security reasons. Traditional networking devices such as routers cannot dynamically load and unload extended services to achieve different qualities of services. In this paper, a new scheme of using the active network to support the mobile IP is presented. The Softnet, a prototype of active networks based on mobile agents,is introduced. The active network is characterized by the programmability of its intermediatenodes and therefore presents dynamic and flexible behaviors. Special services can be dynamically deployed onto the active nodes in the Softnet. This property is definitely required in implementing the mobile IP protocols. The Softnet supports not only the basic mobile IP protocol but also other extended mobile IP protocols. Virtual networks for mobile IP services are dynamically formed by mobile agents in the Softnet to provide different qualities of services.

  10. Mobile Learning in Medical Education: Review.

    Science.gov (United States)

    Walsh, Kieran

    2015-10-01

    In the past several years, mobile learning made rapid inroads into the provision of medical education. There are significant advantages associated with mobile learning. These include high access, low cost, more situated and contextual learning, convenience for the learner, continuous communication and interaction between learner and tutor and between learner and other learners, and the ability to self-assess themselves while learning. Like any other form of medical pedagogy, mobile learning has its downsides. Disadvantages of mobile learning include: inadequate technology, a risk of distraction from learning by using a device that can be used for multiple purposes, and the potential for breakdown in barriers between personal usage of the mobile device and professional or educational use. Despite these caveats, there is no question but that mobile learning offers much potential. In the future, it is likely that the strategy of mobile first, whereby providers of e-learning think of the user experience on a mobile first, will result in learners who increasingly expect that all e-learning provision will work seamlessly on a mobile device.

  11. Toward Risk Reduction for Mobile Service Composition.

    Science.gov (United States)

    Deng, Shuiguang; Huang, Longtao; Li, Ying; Zhou, Honggeng; Wu, Zhaohui; Cao, Xiongfei; Kataev, Mikhail Yu; Li, Ling

    2016-08-01

    The advances in mobile technologies enable us to consume or even provide services through powerful mobile devices anytime and anywhere. Services running on mobile devices within limited range can be composed to coordinate together through wireless communication technologies and perform complex tasks. However, the mobility of users and devices in mobile environment imposes high risk on the execution of the tasks. This paper targets reducing this risk by constructing a dependable service composition after considering the mobility of both service requesters and providers. It first proposes a risk model and clarifies the risk of mobile service composition; and then proposes a service composition approach by modifying the simulated annealing algorithm. Our objective is to form a service composition by selecting mobile services under the mobility model and to ensure the service composition have the best quality of service and the lowest risk. The experimental results demonstrate that our approach can yield near-optimal solutions and has a nearly linear complexity with respect to a problem size.

  12. Putative cholesterol-binding sites in human immunodeficiency virus (HIV) coreceptors CXCR4 and CCR5.

    Science.gov (United States)

    Zhukovsky, Mikhail A; Lee, Po-Hsien; Ott, Albrecht; Helms, Volkhard

    2013-04-01

    Using molecular docking, we identified a cholesterol-binding site in the groove between transmembrane helices 1 and 7 near the inner membrane-water interface of the G protein-coupled receptor CXCR4, a coreceptor for HIV entry into cells. In this docking pose, the amino group of lysine K67 establishes a hydrogen bond with the hydroxyl group of cholesterol, whereas tyrosine Y302 stacks with cholesterol by its aromatic side chain, and a number of residues form hydrophobic contacts with cholesterol. Sequence alignment showed that a similar putative cholesterol-binding site is also present in CCR5, another HIV coreceptor. We suggest that the interaction of cholesterol with these putative cholesterol-binding sites in CXCR4 and CCR5 is responsible for the presence of these receptors in lipid rafts, for the effect of cholesterol on their conformational stability and function, and for the role that cell cholesterol plays in the cell entry of HIV strains that use these membrane proteins as coreceptors. We propose that mutations of residues that are involved in cholesterol binding will make CXCR4 and CCR5 insensitive to membrane cholesterol content. Cholesterol-binding sites in HIV coreceptors are potential targets for steroid drugs that bind to CXCR4 and CCR5 with higher binding affinity than cholesterol, but do not stabilize the native conformation of these proteins.

  13. On the Origin of the Supergiant HI Shell and Putative Companion in NGC 6822

    CERN Document Server

    Cannon, John M; Weisz, Daniel R; Skillman, Evan D; Dolphin, Andrew E; Bigiel, Frank; Cole, Andrew A; de Blok, W J G; Walter, Fabian

    2012-01-01

    We present new Hubble Space Telescope Advanced Camera for Surveys imaging of six positions spanning 5.8 kpc of the HI major axis of the Local Group dIrr NGC 6822, including both the putative companion galaxy and the large HI hole. The resulting deep color magnitude diagrams show that NGC 6822 has formed >50% of its stars in the last ~5 Gyr. The star formation histories of all six positions are similar over the most recent 500 Myr, including low-level star formation throughout this interval and a weak increase in star formation rate during the most recent 50 Myr. Stellar feedback can create the giant HI hole, assuming that the lifetime of the structure is longer than 500 Myr; such long-lived structures have now been observed in multiple systems and may be the norm in galaxies with solid-body rotation. The old stellar populations (red giants and red clump stars) of the putative companion are consistent with those of the extended halo of NGC 6822; this argues against the interpretation of this structure as a bon...

  14. ON THE ORIGIN OF THE SUPERGIANT H I SHELL AND PUTATIVE COMPANION IN NGC 6822

    Energy Technology Data Exchange (ETDEWEB)

    Cannon, John M.; O' Leary, Erin M. [Department of Physics and Astronomy, Macalester College, 1600 Grand Avenue, Saint Paul, MN 55105 (United States); Weisz, Daniel R. [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); Skillman, Evan D. [Minnesota Institute for Astrophysics, University of Minnesota, Minneapolis, MN 55455 (United States); Dolphin, Andrew E. [Raytheon Company, 1151 East Hermans Road, Tucson, AZ 85706 (United States); Bigiel, Frank [Institut fuer Theoretische Astrophysik, Universitaet Heidelberg, Albert-Ueberle-Str. 2, 69120 Heidelberg (Germany); Cole, Andrew A.; Walter, Fabian [School of Mathematics and Physics, University of Tasmania, Private Bag 37, Hobart 7001, Tasmania (Australia); De Blok, W.J.G., E-mail: jcannon@macalester.edu, E-mail: eoleary@macalester.edu, E-mail: dweisz@astro.washington.edu, E-mail: skillman@astro.umn.edu, E-mail: adolphin@raytheon.com, E-mail: bigiel@uni-heidelberg.de, E-mail: andrew.cole@utas.edu.au, E-mail: edeblok@ast.uct.ac.za, E-mail: walter@mpia.de [Department of Astronomy, University of Cape Town, Rondebosch 7700 (South Africa)

    2012-03-10

    We present new Hubble Space Telescope Advanced Camera for Surveys imaging of six positions spanning 5.8 kpc of the H I major axis of the Local Group dIrr NGC 6822, including both the putative companion galaxy and the large H I hole. The resulting deep color-magnitude diagrams show that NGC 6822 has formed >50% of its stars in the last {approx}5 Gyr. The star formation histories of all six positions are similar over the most recent 500 Myr, including low-level star formation throughout this interval and a weak increase in star formation rate during the most recent 50 Myr. Stellar feedback can create the giant H I hole, assuming that the lifetime of the structure is longer than 500 Myr; such long-lived structures have now been observed in multiple systems and may be the norm in galaxies with solid-body rotation. The old stellar populations (red giants and red clump stars) of the putative companion are consistent with those of the extended halo of NGC 6822; this argues against the interpretation of this structure as a bona fide interacting companion galaxy and against its being linked to the formation of the H I hole via an interaction. Since there is no evidence in the stellar population of a companion galaxy, the most likely explanation of the extended H I structure in NGC 6822 is a warped disk inclined to the line of sight.

  15. Evolution and structural diversification of PILS putative auxin carriers in plants

    Directory of Open Access Journals (Sweden)

    Elena eFeraru

    2012-10-01

    Full Text Available The phytohormone auxin contributes to virtually every aspect of the plant development. The spatiotemporal distribution of auxin depends on a complex interplay between auxin metabolism and intercellular auxin transport. Intracellular auxin compartmentalization provides another link between auxin transport processes and auxin metabolism. The PIN-LIKES (PILS putative auxin carriers localize to the endoplasmic reticulum (ER and contribute to cellular auxin homeostasis. PILS proteins regulate intracellular auxin accumulation, the rate of auxin conjugation and subsequently, affect nuclear auxin signalling. Here, we investigate sequence diversification of the PILS family in Arabidopsis thaliana and provide insights into the evolution of these novel putative auxin carriers in plants. Our data suggest that PILS proteins are conserved throughout the plant lineage and expanded during higher plant evolution. PILS proteins diversified early during plant evolution into three clades. Besides the ancient Clade I encompassing non-land plant species, PILS proteins evolved into two clades. The diversification of Clade II and Clade III occurred already at the level of non-vascular plant evolution and, hence, both clades contain vascular and non-vascular plant species. Nevertheless, Clade III contains fewer non- and increased numbers of vascular plants, indicating higher importance of Clade III for vascular plant evolution. Notably, PILS proteins are distinct and appear evolutionarily older than the prominent PIN-FORMED auxin carriers. Moreover, we revealed particular PILS sequence divergence in Arabidopsis and assume that these alterations could contribute to distinct gene regulations and protein functions.

  16. Regulation of Arabidopsis Early Anther Development by Putative Cell-Cell Signaling Molecules and Transcriptional Regulators

    Institute of Scientific and Technical Information of China (English)

    Yu-Jin Sun; Carey LH Hord; Chang-Bin Chen; Hong Ma

    2007-01-01

    Anther development in flowering plants involves the formation of several cell types, including the tapetal and pollen mother cells. The use of genetic and molecular tools has led to the identification and characterization of genes that are critical for normal cell division and differentiation in Arabidopsis early anther development. We review here several recent studies on these genes, including the demonstration that the putative receptor protein kinases BAM1 and BAM2 together play essential roles in the control of early cell division and differentiation. In addition, we discuss the hypothesis that BAM1/2 may form a positive-negative feedback regulatory loop with a previously identified key regulator, SPOROCYTELESS (also called NOZZLE),to control the balance between sporogenous and somatic cell types in the anther. Furthermore, we summarize the isolation and functional analysis of the DYSFUNCTIONAL TAPETUM1 (DYT1) gene in promoting proper tapetal cell differentiation. Our finding that DYT1 encodes a putative transcription factor of the bHLH family, as well as relevant expression analyses, strongly supports a model that DYT1 serves as a critical link between upstream factors and downstream target genes that are critical for normal tapetum development and function. These studies, together with other recently published works, indicate that cell-cell communication and transcriptional control are key processes essential for cell fate specification in anther development.

  17. Characterization of Putative cis-Regulatory Elements in Genes Preferentially Expressed in Arabidopsis Male Meiocytes

    Directory of Open Access Journals (Sweden)

    Junhua Li

    2014-01-01

    Full Text Available Meiosis is essential for plant reproduction because it is the process during which homologous chromosome pairing, synapsis, and meiotic recombination occur. The meiotic transcriptome is difficult to investigate because of the size of meiocytes and the confines of anther lobes. The recent development of isolation techniques has enabled the characterization of transcriptional profiles in male meiocytes of Arabidopsis. Gene expression in male meiocytes shows unique features. The direct interaction of transcription factors (TFs with DNA regulatory sequences forms the basis for the specificity of transcriptional regulation. Here, we identified putative cis-regulatory elements (CREs associated with male meiocyte-expressed genes using in silico tools. The upstream regions (1 kb of the top 50 genes preferentially expressed in Arabidopsis meiocytes possessed conserved motifs. These motifs are putative binding sites of TFs, some of which share common functions, such as roles in cell division. In combination with cell-type-specific analysis, our findings could be a substantial aid for the identification and experimental verification of the protein-DNA interactions for the specific TFs that drive gene expression in meiocytes.

  18. Putative monofunctional type I polyketide synthase units: a dinoflagellate-specific feature?

    Directory of Open Access Journals (Sweden)

    Karsten Eichholz

    Full Text Available Marine dinoflagellates (alveolata are microalgae of which some cause harmful algal blooms and produce a broad variety of most likely polyketide synthesis derived phycotoxins. Recently, novel polyketide synthesase (PKS transcripts have been described from the Florida red tide dinoflagellate Karenia brevis (gymnodiniales which are evolutionarily related to Type I PKS but were apparently expressed as monofunctional proteins, a feature typical of Type II PKS. Here, we investigated expression units of PKS I-like sequences in Alexandrium ostenfeldii (gonyaulacales and Heterocapsa triquetra (peridiniales at the transcript and protein level. The five full length transcripts we obtained were all characterized by polyadenylation, a 3' UTR and the dinoflagellate specific spliced leader sequence at the 5'end. Each of the five transcripts encoded a single ketoacylsynthase (KS domain showing high similarity to K. brevis KS sequences. The monofunctional structure was also confirmed using dinoflagellate specific KS antibodies in Western Blots. In a maximum likelihood phylogenetic analysis of KS domains from diverse PKSs, dinoflagellate KSs formed a clade placed well within the protist Type I PKS clade between apicomplexa, haptophytes and chlorophytes. These findings indicate that the atypical PKS I structure, i.e., expression as putative monofunctional units, might be a dinoflagellate specific feature. In addition, the sequenced transcripts harbored a previously unknown, apparently dinoflagellate specific conserved N-terminal domain. We discuss the implications of this novel region with regard to the putative monofunctional organization of Type I PKS in dinoflagellates.

  19. Molecular genetics: DNA analysis of a putative dog clone.

    Science.gov (United States)

    Parker, Heidi G; Kruglyak, Leonid; Ostrander, Elaine A

    2006-03-09

    In August 2005, Lee et al. reported the first cloning of a domestic dog from adult somatic cells. This putative dog clone was the result of somatic-cell nuclear transfer from a fibroblast cell of a three-year-old male Afghan hound into a donor oocyte provided by a dog of mixed breed. In light of recent concerns regarding the creation of cloned human cell lines from the same institution, we have undertaken an independent test to determine the validity of the claims made by Lee et al..

  20. Learning to Be Mobile

    DEFF Research Database (Denmark)

    McIlvenny, Paul

    of this creative cyclomobility research focuses on adult cycling or more extreme sports, such as BMX trials or mountain biking. There is, however, little qualitative research to date on family bike rides, eg. how children learn to sit in or ride a bike and how parents or caregivers talk and interact with children...... to instruct them in how to ride safely and to construct the moral order of the road in situ. Moreover, much research conducted in the US/UK depicts a hostile urban environment for bikes, in which bikers must navigate a dangerous, car-centred roadscape. This paper reports on a preliminary investigation of two...... features of the local organisation of the ride from the participants’ perspective(s). In addition, new ways to represent (in transcript form) specific features of the sensefulness of riding together were developed, eg. the relative mobility of different actors while doing ‘being mobile’. Several phenomena...

  1. Head First Mobile Web

    CERN Document Server

    Gardner, Lyza; Grigsby, Jason

    2011-01-01

    Despite the huge number of mobile devices and apps in use today, your business still needs a website. You just need it to be mobile. Head First Mobile Web walks you through the process of making a conventional website work on a variety smartphones and tablets. Put your JavaScript, CSS media query, and HTML5 skills to work-then optimize your site to perform its best in the demanding mobile market. Along the way, you'll discover how to adapt your business strategy to target specific devices. Navigate the increasingly complex mobile landscapeTake both technical and strategic approaches to mobile

  2. Mobile Portal Implementation Strategy

    DEFF Research Database (Denmark)

    Gao, Ping; Damsgaard, Jan

    2005-01-01

    Mobile portal plays an important role in mobile commerce market. Current literature focuses on static analysis on the value chain of mobile portals. This article provides a dynamic perspective on mobile portal strategy. Drawing upon network economics, we describe mobile portal implementation...... as a fourphase process. In different phase, a portal provider has various challenges to overcome and adopt diverse strategies, and correspondingly the regulator has different foci. The conceptual framework proposed in this article offers a basis for further analyses on the market dynamics of mobile commerce......, and can be generalized to studying other networked technologies...

  3. Mobile Router Technology Development

    Science.gov (United States)

    Ivancic, William D.; Stewart, David H.; Bell, Terry L.; Kachmar, Brian A.; Shell, Dan; Leung, Kent

    2002-01-01

    Cisco Systems and NASA have been performing joint research on mobile routing technology under a NASA Space Act Agreement. Cisco developed mobile router technology and provided that technology to NASA for applications to aeronautic and space-based missions. NASA has performed stringent performance testing of the mobile router, including the interaction of routing and transport-level protocols. This paper describes mobile routing, the mobile router, and some key configuration parameters. In addition, the paper describes the mobile routing test network and test results documenting the performance of transport protocols in dynamic routing environments.

  4. Genetic profiling of putative breast cancer stem cells from malignant pleural effusions.

    Science.gov (United States)

    Tiran, Verena; Stanzer, Stefanie; Heitzer, Ellen; Meilinger, Michael; Rossmann, Christopher; Lax, Sigurd; Tsybrovskyy, Oleksiy; Dandachi, Nadia; Balic, Marija

    2017-01-01

    A common symptom during late stage breast cancer disease is pleural effusion, which is related to poor prognosis. Malignant cells can be detected in pleural effusions indicating metastatic spread from the primary tumor site. Pleural effusions have been shown to be a useful source for studying metastasis and for isolating cells with putative cancer stem cell (CSC) properties. For the present study, pleural effusion aspirates from 17 metastatic breast cancer patients were processed to propagate CSCs in vitro. Patient-derived aspirates were cultured under sphere forming conditions and isolated primary cultures were further sorted for cancer stem cell subpopulations ALDH1+ and CD44+CD24-/low. Additionally, sphere forming efficiency of CSC and non-CSC subpopulations was determined. In order to genetically characterize the different tumor subpopulations, DNA was isolated from pleural effusions before and after cell sorting, and compared with corresponding DNA copy number profiles from primary tumors or bone metastasis using low-coverage whole genome sequencing (SCNA-seq). In general, unsorted cells had a higher potential to form spheres when compared to CSC subpopulations. In most cases, cell sorting did not yield sufficient cells for copy number analysis. A total of five from nine analyzed unsorted pleura samples (55%) showed aberrant copy number profiles similar to the respective primary tumor. However, most sorted subpopulations showed a balanced profile indicating an insufficient amount of tumor cells and low sensitivity of the sequencing method. Finally, we were able to establish a long term cell culture from one pleural effusion sample, which was characterized in detail. In conclusion, we confirm that pleural effusions are a suitable source for enrichment of putative CSC. However, sequencing based molecular characterization is impeded due to insufficient sensitivity along with a high number of normal contaminating cells, which are masking genetic alterations of

  5. Isolation and identification of Porphyromonas spp. and other putative pathogens from cats with periodontal disease.

    Science.gov (United States)

    Pérez-Salcedo, L; Herrera, D; Esteban-Saltiveri, D; León, R; Jeusette, I; Torre, C; O'Connor, A; González, I; González, I

    2013-01-01

    The purpose of this study was to evaluate the subgingival microbiota and determine the most prevalent periodontal pathogens implicated in feline periodontal disease and to correlate these findings with the clinical periodontal status. Subgingival microbiological samples were taken under sedation from 50 cats with clinical signs of periodontal disease. Pooled paper point samples from 4 selected subgingival sites were cultured on blood agar and on Dentaid-1 medium. Suspected pathogens were identified, subcultured, and preserved. The association between the microbiological findings and the clinical status was studied using correlation coefficients (CC). In addition, cats were stratified in subgroups according to presence of putative pathogens, and comparisons were carried out using unpaired t-test. Three bacterial species were frequently detected including Porphyromonas gulae (86%), Porphyromonas circumdentaria (70%) and Fusobacterium nucleatum (90%). The mean proportion of total flora was high for P. gulae (32.54%), moderate for P. circundentaria (8.82%), and low for F. nucleatum (3.96%). Among the clinical variables, tooth mobility was correlated (CC > 0.50, p < 0.001) with recession, pocket depth, attachment level, gingival index, and calculus index (CC = 0.29, p = 0.04) as well as with total bacterial counts (CC = 0.38, p = 0.006). Cats with more than 10% of P. gulae showed significantly more mobility (p = 0.014) and recession (p = 0.038), and a tendency for deeper probing pocket depths (p = 0.084) and attachment loss (p = 0.087). The results from this cross-sectional study confirmed that P. gulae is the most relevant pathogen in periodontal disease in cats.

  6. MobiLED: mobile-led and leading via mobile

    CSIR Research Space (South Africa)

    Ford, M

    2009-03-01

    Full Text Available ” of these devices. MobilED (Mobile EDucation) started as a 3-year initiative in 2006 which aimed to take advantage of the cell phone as the only effective technology device in the hands of African children and youth. Although cell phones currently do not play...-and-SMS-only models through to multimedia and smartphones; 2. GSM/GPRS/3G/Bluetooth communication channels; 3. Wikipedia: The Free Encyclopedia; 4. Social Software: MediaWiki, blogs; instant messaging; 5. Open Source Language technologies: Speech interfaces...

  7. Narrative form

    CERN Document Server

    Keen, Suzanne

    2015-01-01

    This revised and expanded handbook concisely introduces narrative form to advanced students of fiction and creative writing, with refreshed references and new discussions of cognitive approaches to narrative, nonfiction, and narrative emotions.

  8. Mobile robot sense net

    Science.gov (United States)

    Konolige, Kurt G.; Gutmann, Steffen; Guzzoni, Didier; Ficklin, Robert W.; Nicewarner, Keith E.

    1999-08-01

    Mobile robot hardware and software is developing to the point where interesting applications for groups of such robots can be contemplated. We envision a set of mobots acting to map and perform surveillance or other task within an indoor environment (the Sense Net). A typical application of the Sense Net would be to detect survivors in buildings damaged by earthquake or other disaster, where human searchers would be put a risk. As a team, the Sense Net could reconnoiter a set of buildings faster, more reliably, and more comprehensibly than an individual mobot. The team, for example, could dynamically form subteams to perform task that cannot be done by individual robots, such as measuring the range to a distant object by forming a long baseline stereo sensor form a pari of mobots. In addition, the team could automatically reconfigure itself to handle contingencies such as disabled mobots. This paper is a report of our current progress in developing the Sense Net, after the first year of a two-year project. In our approach, each mobot has sufficient autonomy to perform several tasks, such as mapping unknown areas, navigating to specific positions, and detecting, tracking, characterizing, and classifying human and vehicular activity. We detail how some of these tasks are accomplished, and how the mobot group is tasked.

  9. Saddlebags, Paperbacks and Mobile Media

    Science.gov (United States)

    Zwick, Carola

    Information is shaped by its format. The printing press with its repeatable layout laid ground for footnotes and references from other sources, and thus can be seen as the technology that initially generated the concept of hyperlinks. In the fifteenth century, printed matter quickly developed other formats like the paperback book or the flyer. These formats changed the content in almost every aspect significantly: books that fit in a saddlebag are mobile media and thus not as precious as the gigantic and prestigious folio placed on a lectern stand in a monastery. So books became a widespread, "ordinary" mobile medium and developed a multitude of purposes, aimed at different audiences, and generated a wide range of ideas for adequate content. The flyer in its limited size and public nature generated other forms of organizing and designing content: in order to fit the format and draw attention it uses a condensed form of messaging and an exaggerated typography.

  10. Exploring the Mobility of Mobile Phone Users

    CERN Document Server

    Csáji, Balázs Cs; Traag, V A; Delvenne, Jean-Charles; Huens, Etienne; Van Dooren, Paul; Smoreda, Zbigniew; Blondel, Vincent D

    2013-01-01

    Mobile phone datasets allow for the analysis of human behavior on an unprecedented scale. The social network, temporal dynamics and mobile behavior of mobile phone users have often been analyzed independently from each other using mobile phone datasets. In this article, we explore the connections between various features of human behavior extracted from a large mobile phone dataset. Our observations are based on the analysis of communication data of 100000 anonymized and randomly chosen individuals in a dataset of communications in Portugal. We show that clustering and principal component analysis allow for a significant dimension reduction with limited loss of information. The most important features are related to geographical location. In particular, we observe that most people spend most of their time at only a few locations. With the help of clustering methods, we then robustly identify home and office locations and compare the results with official census data. Finally, we analyze the geographic spread ...

  11. Solid colloids with surface-mobile linkers.

    Science.gov (United States)

    van der Meulen, Stef A J; Helms, Gesa; Dogterom, Marileen

    2015-06-17

    In this report we review the possibilities of using colloids with surface mobile linkers for the study of colloidal self-assembly processes. A promising route to create systems with mobile linkers is the use of lipid (bi-)layers. These lipid layers can be either used in the form of vesicles or as coatings for hard colloids and emulsion droplets. Inside the lipid bilayers molecules can be inserted via membrane anchors. Due to the fluidity of the lipid bilayer, the anchored molecules remain mobile. The use of different lipid mixtures even allows creating Janus-like particles that exhibit directional bonding if linkers are used which have a preference for a certain lipid phase. In nature mobile linkers can be found e.g. as receptors in cells. Therefore, towards the end of the review, we also briefly address the possibility of using colloids with surface mobile linkers as model systems to mimic cell-cell interactions and cell adhesion processes.

  12. Workforce mobility: Contributing towards smart city

    Science.gov (United States)

    Nor, N. M.; Wahap, N. A.

    2014-02-01

    Smart cities gained importance as a means of making ICT enabled services and applications available to the citizens, companies and authorities that form part of a city's system. It aims at increasing citizen's quality of life, and improving the efficiency and quality of the services provided by governing entities and businesses. This perspective requires an integrated vision of a city and of its infrastructures in all components. One of the characteristics of a smart city is mobility. The concept of mobility, especially for the workforce, is studied through a research carried out on a daily work undertaken as a prototype in the administrative town of Putrajaya, Malaysia. Utilizing the location track from GNSS integrated with mobile devices platform, information on movement and mobility was analysed for quality and efficiency of services rendered. This paper will highlight the research and outcomes that were successfully carried out and will suggest that workforce mobility management can benefit the authorities towards implementing a smart city concept.

  13. Putative golden proportions as predictors of facial esthetics in adolescents.

    Science.gov (United States)

    Kiekens, Rosemie M A; Kuijpers-Jagtman, Anne Marie; van 't Hof, Martin A; van 't Hof, Bep E; Maltha, Jaap C

    2008-10-01

    In orthodontics, facial esthetics is assumed to be related to golden proportions apparent in the ideal human face. The aim of the study was to analyze the putative relationship between facial esthetics and golden proportions in white adolescents. Seventy-six adult laypeople evaluated sets of photographs of 64 adolescents on a visual analog scale (VAS) from 0 to 100. The facial esthetic value of each subject was calculated as a mean VAS score. Three observers recorded the position of 13 facial landmarks included in 19 putative golden proportions, based on the golden proportions as defined by Ricketts. The proportions and each proportion's deviation from the golden target (1.618) were calculated. This deviation was then related to the VAS scores. Only 4 of the 19 proportions had a significant negative correlation with the VAS scores, indicating that beautiful faces showed less deviation from the golden standard than less beautiful faces. Together, these variables explained only 16% of the variance. Few golden proportions have a significant relationship with facial esthetics in adolescents. The explained variance of these variables is too small to be of clinical importance.

  14. CRYSTAL STRUCTURE ANALYSIS OF A PUTATIVE OXIDOREDUCTASE FROM KLEBSIELLA PNEUMONIAE

    Energy Technology Data Exchange (ETDEWEB)

    Baig, M.; Brown, A.; Eswaramoorthy, S.; Swaminathan, S.

    2009-01-01

    Klebsiella pneumoniae, a gram-negative enteric bacterium, is found in nosocomial infections which are acquired during hospital stays for about 10% of hospital patients in the United States. The crystal structure of a putative oxidoreductase from K. pneumoniae has been determined. The structural information of this K. pneumoniae protein was used to understand its function. Crystals of the putative oxidoreductase enzyme were obtained by the sitting drop vapor diffusion method using Polyethylene glycol (PEG) 3350, Bis-Tris buffer, pH 5.5 as precipitant. These crystals were used to collect X-ray data at beam line X12C of the National Synchrotron Light Source (NSLS) at Brookhaven National Laboratory (BNL). The crystal structure was determined using the SHELX program and refi ned with CNS 1.1. This protein, which is involved in the catalysis of an oxidation-reduction (redox) reaction, has an alpha/beta structure. It utilizes nicotinamide adenine dinucleotide phosphate (NADP) or nicotine adenine dinucleotide (NAD) to perform its function. This structure could be used to determine the active and co-factor binding sites of the protein, information that could help pharmaceutical companies in drug design and in determining the protein’s relationship to disease treatment such as that for pneumonia and other related pathologies.

  15. Modeling putative therapeutic implications of exosome exchange between tumor and immune cells.

    Science.gov (United States)

    Lu, Mingyang; Huang, Bin; Hanash, Samir M; Onuchic, José N; Ben-Jacob, Eshel

    2014-10-07

    Development of effective strategies to mobilize the immune system as a therapeutic modality in cancer necessitates a better understanding of the contribution of the tumor microenvironment to the complex interplay between cancer cells and the immune response. Recently, effort has been directed at unraveling the functional role of exosomes and their cargo of messengers in this interplay. Exosomes are small vesicles (30-200 nm) that mediate local and long-range communication through the horizontal transfer of information, such as combinations of proteins, mRNAs and microRNAs. Here, we develop a tractable theoretical framework to study the putative role of exosome-mediated cell-cell communication in the cancer-immunity interplay. We reduce the complex interplay into a generic model whose three components are cancer cells, dendritic cells (consisting of precursor, immature, and mature types), and killer cells (consisting of cytotoxic T cells, helper T cells, effector B cells, and natural killer cells). The framework also incorporates the effects of exosome exchange on enhancement/reduction of cell maturation, proliferation, apoptosis, immune recognition, and activation/inhibition. We reveal tristability-possible existence of three cancer states: a low cancer load with intermediate immune level state, an intermediate cancer load with high immune level state, and a high cancer load with low immune-level state, and establish the corresponding effective landscape for the cancer-immunity network. We illustrate how the framework can contribute to the design and assessments of combination therapies.

  16. Innovative Design of Gear System for Mobile Pipe Thread Forming Machines%可移式管螺纹成形机传动装置创新设计

    Institute of Scientific and Technical Information of China (English)

    安美玲; 穆玺清

    2011-01-01

    对管螺纹成形机传动装置进行了设计方案分析和比较,设计了无轴式二级齿轮传动装置,应用Matlab软件对其尺寸参数进行了优化,使该传动装置结构紧凑,便于移动.%Design schemes for gear system of pipe thread forming machines were analyzed and compared to design a shaftless two-stage gear system and to have its size parameters optimized with Matlab software. The compact structure and easy to move characterize this gear system.

  17. Tandem mobile robot system

    Energy Technology Data Exchange (ETDEWEB)

    Buttz, James H. (Albuquerque, NM); Shirey, David L. (Albuquerque, NM); Hayward, David R. (Albuquerque, NM)

    2003-01-01

    A robotic vehicle system for terrain navigation mobility provides a way to climb stairs, cross crevices, and navigate across difficult terrain by coupling two or more mobile robots with a coupling device and controlling the robots cooperatively in tandem.

  18. Mobile systems development

    DEFF Research Database (Denmark)

    Pedersen, Ole; Kristiansen, Martin Lund; Kammersgaard, Marc N.

    2007-01-01

    Development of mobile software is Surrounded by much uncertainty. Immature software platforms on mobile clients, a highly competitive market calling for innovation, efficiency and effectiveness in the development life cycle, and lacking end-user adoption are just some of the realities facing...... development teams in the mobile software industry. By taking a process view on development of mobile systems we seek to explore the strengths and limitations of eXtreme Programming (XP) in the context of mobile software development. Following an experimental approach a mobile systems development project...... running for four months is conducted. Experiences from the project are used for analysis and discussion of the fit of XP in mobile systems development. First, requirements for mobile systems development projects are proposed. Second, these are analysed and compared to the prescribed principles suggested...

  19. Mobile Informal Learning

    NARCIS (Netherlands)

    Glahn, Christian; Börner, Dirk

    2010-01-01

    Glahn, C., & Börner, D. (2009). Mobile Informal Learning. Presented at Mobile Learning in Context Symposium at the Open University of the Netherlands. September, 11, 2009, Heerlen, The Netherlands: Open University of the Netherlands.

  20. Mobile Informal Learning

    NARCIS (Netherlands)

    Glahn, Christian; Börner, Dirk

    2010-01-01

    Glahn, C., & Börner, D. (2009). Mobile Informal Learning. Presented at Mobile Learning in Context Symposium at the Open University of the Netherlands. September, 11, 2009, Heerlen, The Netherlands: Open University of the Netherlands.

  1. Mobile Phones on Campus

    Institute of Scientific and Technical Information of China (English)

    朴春宝

    2007-01-01

    After entering the 21st century, more and more people have mobile phones in China. At the end of 2002, there were 20 million mobile phone users. By the year 2005 the number has reached up to 30 million.

  2. ECG by mobile technologies.

    Science.gov (United States)

    Guzik, Przemyslaw; Malik, Marek

    Mobile electrocardiographs consist of three components: a mobile device (e.g. a smartphone), an electrocardiographic device or accessory, and a mobile application. Mobile platforms are small computers with sufficient computational power, good quality display, suitable data storage, and several possibilities of data transmission. Electrocardiographic electrodes and sensors for mobile use utilize unconventional materials, e.g. rubber, e-textile, and inkjet-printed nanoparticle electrodes. Mobile devices can be handheld, worn as vests or T-shirts, or attached to patient's skin as biopatches. Mobile electrocardiographic devices and accessories may additionally record other signals including respiratory rate, activity level, and geolocation. Large-scale clinical studies that utilize electrocardiography are easier to conduct using mobile technologies and the collected data are suitable for "big data" processing. This is expected to reveal phenomena so far inaccessible by standard electrocardiographic techniques.

  3. Mobile IP: Security & application

    NARCIS (Netherlands)

    Tuquerres, Gloria; Salvador, Marcos Rogério; Sprenkels, Ron

    1999-01-01

    As required in the TGS Mobile IP Advanced Module, this paper presents a survey of common security threats which mobile IP networks are exposed to as well as some proposed solutions to deal with such threats.

  4. Mobile systems development

    DEFF Research Database (Denmark)

    Pedersen, Ole; Kristiansen, Martin Lund; Kammersgaard, Marc N.

    2007-01-01

    Development of mobile software is Surrounded by much uncertainty. Immature software platforms on mobile clients, a highly competitive market calling for innovation, efficiency and effectiveness in the development life cycle, and lacking end-user adoption are just some of the realities facing...... development teams in the mobile software industry. By taking a process view on development of mobile systems we seek to explore the strengths and limitations of eXtreme Programming (XP) in the context of mobile software development. Following an experimental approach a mobile systems development project...... running for four months is conducted. Experiences from the project are used for analysis and discussion of the fit of XP in mobile systems development. First, requirements for mobile systems development projects are proposed. Second, these are analysed and compared to the prescribed principles suggested...

  5. Fundamental Properties of Wireless Mobile Ad-hoc Networks

    NARCIS (Netherlands)

    Hekmat, R.

    2005-01-01

    Wireless mobile ad-hoc networks are formed by mobile devices that set up a possibly short-lived network for communication needs of the moment. Ad-hoc networks are decentralized, self-organizing networks capable of forming a communication network without relying on any fixed infrastructure. Each nod

  6. Fixed mobile convergence handbook

    CERN Document Server

    Ahson, Syed A

    2010-01-01

    From basic concepts to future directions, this handbook provides technical information on all aspects of fixed-mobile convergence (FMC). The book examines such topics as integrated management architecture, business trends and strategic implications for service providers, personal area networks, mobile controlled handover methods, SIP-based session mobility, and supervisory and notification aggregator service. Case studies are used to illustrate technical and systematic implementation of unified and rationalized internet access by fixed-mobile network convergence. The text examines the technolo

  7. Mobile Learning Applications Audit

    OpenAIRE

    2010-01-01

    While mobile learning (m-learning) applications have proven their value in educational activities, there is a need to measure their reliability, accessibility and further more their trustworthiness. Mobile devices are far more vulnerable then classic computers and present inconvenient interfaces due to their size, hardware limitations and their mobile connectivity. Mobile learning applications should be audited to determine if they should be trusted or not, while multimedia contents like auto...

  8. Ion mobility spectrometry

    CERN Document Server

    Eiceman, GA

    2005-01-01

    Key Developments for Faster, More Precise Detection Capabilities Driven by the demand for the rapid and advanced detection of explosives, chemical and biological warfare agents, and narcotics, ion mobility spectrometry (IMS) undergone significant refinements in technology, computational capabilities, and understanding of the principles of gas phase ion chemistry and mobility. Beginning with a thorough discussion of the fundamental theories and physics of ion mobility, Ion Mobility Spectrometry, Second Edition describes the recent advances in instrumentation and newly

  9. Staging interrail mobilities

    DEFF Research Database (Denmark)

    Jensen, Martin Trandberg; Gyimóthy, Szilvia; Jensen, Ole B.

    2016-01-01

    This article applies the multiscalar ‘staging mobilities’ framework from the emergent subfield of mobilities design to analyse an enduring European rail travel phenomenon, interrail. This discussion extends and contributes to tourism mobilities research. Second, the article enriches previous...... and seat reservations. To reach these aims, the research design intertwines multi-sited ethnography, netnography, survey and interviews. The conclusion offers theoretical reflections pertaining to the role of mobilities designs and methodical hybrids in tourism mobilities research....

  10. Fri form

    DEFF Research Database (Denmark)

    Jensen, Henrik

    2006-01-01

    Dette Kompendiun er lavet i forbindelse med en workshop i møbeldesign. En række af form-Z's værktøjer til konstruktion af dobbeltkrumme flader gennemgås. Kompendiet kan bruges til selvstudie.......Dette Kompendiun er lavet i forbindelse med en workshop i møbeldesign. En række af form-Z's værktøjer til konstruktion af dobbeltkrumme flader gennemgås. Kompendiet kan bruges til selvstudie....

  11. Mobile Student Information System

    Science.gov (United States)

    Asif, Muhammad; Krogstie, John

    2011-01-01

    Purpose: A mobile student information system (MSIS) based on mobile computing and context-aware application concepts can provide more user-centric information services to students. The purpose of this paper is to describe a system for providing relevant information to students on a mobile platform. Design/methodology/approach: The research…

  12. Mobile Student Information System

    Science.gov (United States)

    Asif, Muhammad; Krogstie, John

    2011-01-01

    Purpose: A mobile student information system (MSIS) based on mobile computing and context-aware application concepts can provide more user-centric information services to students. The purpose of this paper is to describe a system for providing relevant information to students on a mobile platform. Design/methodology/approach: The research…

  13. Potenziale des Mobile Commerce

    OpenAIRE

    Turowski, Klaus

    2004-01-01

    Potenziale des Mobile Commerce / B. Bazijanec, K. Turowski. - In: Mobile economy : 4. Workshop Mobile Commerce, 02.-03. Februar 2004, Univ. Augsburg / Key Pousttchi ... (Hrsg.). - Bonn : Ges. für Informatik, 2004. - S. 7-11. - (GI-Edition : Proceedings ; 42)

  14. Revision of the stereochemistry of elisabethatriene, a putative biosynthetic intermediate of pseudopterosins.

    Science.gov (United States)

    Nasuda, Masayuki; Ohmori, Miho; Ohyama, Kiyoshi; Fujimoto, Yoshinori

    2012-01-01

    In the past, we have questioned the accuracy of the stereochemistry of elisabethatriene, a putative biosynthetic intermediate of pseudopterosins, in light of the configuration of elisabethatrienol isolated from Pseudopterogorgia elisabethae, which was represented as 1S,4R,9S,11S. We have reinvestigated the stereochemistry of elisabethatriene. Elisabethatriene with the reported 1S,4R,9R,11S configuration was synthesized starting from (-)-isopulegol in its enantiomeric form. The (1)H- and (13)C-NMR data of the synthesized compound differed from those reported for elisabethatriene. In addition to the fact that elisabethatriene is converted into pseudopterosins, this finding has allowed us to propose that elisabethatriene should have the 1S,4R,9S,11S stereochemistry, which is identical to that of elisabethatrienol.

  15. On the Need of Network coding for Mobile Clouds

    DEFF Research Database (Denmark)

    Fitzek, Frank; Heide, Janus; Pedersen, Morten Videbæk

    This paper advocates the need of network coding for mobile clouds. Mobile clouds as well as network coding are describing two novel concepts. The concept of mobile clouds describes the potential of mobile devices to communicate with each other and form a cooperative cluster in which new services...... and potentials are created. Network coding on the other side enables the mobile cloud to communicate in a very efficient and secure way in terms of energy and bandwidth usage. Even though network coding can be applied in a variety of communication networks, it has some inherent features that makes it suitable...... for mobile clouds. The paper will list the benefits of network coding for mobile clouds as well as introduce both concepts in a tutorial way. The results used throughout this paper are collaborative work of different research institutes, but mainly taken from the mobile device group at Aalborg University....

  16. Automorphic Forms

    DEFF Research Database (Denmark)

    von Essen, Flemming Brændgaard

    systems. For automorphic forms wrt. Hecke triangle groups and Fuchsian groups with no elliptic elements and genus 0, we show that some logarithms of multiplier systems can be interpreted as a linking number. Finally we show a "twisted" version of the prime geodesics theorem, and logarithms of multiplier...

  17. Cosmic Forms

    CERN Document Server

    Kleman, Maurice

    2011-01-01

    The continuous 1D defects of an isotropic homogeneous material in an Euclidean 3D space are classified by a construction method, the Volterra process (VP). We employ the same method to classify the continuous 2D defects (which we call \\textit{cosmic forms}) of a vacuum in a 4D maximally symmetric spacetime. These defects fall into three different classes: i)- $m$-forms, akin to 3D space disclinations, related to ordinary rotations and analogous to Kibble's global cosmic strings (except that being continuous any deficit angle is allowed); ii)- $t$-forms, related to Lorentz boosts (hyperbolic rotations); iii)- $r$-forms, never been considered so far, related to null rotations. A detailed account of their metrics is presented. Their inner structure in many cases appears as a non-singular \\textit{core} separated from the outer part by a timelike hypersurface with distributional curvature and/or torsion, yielding new types of geometrical interactions with cosmic dislocations and other cosmic disclinations. Whereas...

  18. Intermittently connected mobile ad hoc networks

    CERN Document Server

    Jamalipour, Abbas

    2011-01-01

    In the last few years, there has been extensive research activity in the emerging area of Intermittently Connected Mobile Ad Hoc Networks (ICMANs). By considering the nature of intermittent connectivity in most real word mobile environments without any restrictions placed on users' behavior, ICMANs are eventually formed without any assumption with regard to the existence of a end-to-end path between two nodes wishing to communicate. It is different from the conventional Mobile Ad Hoc Networks (MANETs), which have been implicitly viewed as a connected graph with established complete paths betwe

  19. The Research on Mobile-agent Security

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Mobile agent technology offers a new computing paradigm in which a program, in the form of a software agent, can suspend its execution in a host computer, transfer itself to another agent-enabled host in the network, and resume execution of the new host. As the sophistication of mobile software has increased with the time, so have the associated threats to security. This paper provides an overview of the range of threats facing the designers of mobile agent. The paper also identifies generic security objectives, and a range of measures for countering the identified threats.

  20. Predicateμ-Calculus for Mobile Ambients

    Institute of Scientific and Technical Information of China (English)

    Hui-Min Lin

    2005-01-01

    Ambient logics have been proposed to describe properties for mobile agents which may evolve over time as well as space. This paper takes a predicate-based approach to extending an ambient logic with recursion, yielding a predicate t-calculus in which fixpoint formulas are formed using predicate variables. An algorithm is developed for model checking finite-control mobile ambients against formulas of the logic, providing the first decidability result for model checking a spatial logic with recursion.

  1. Exceptional error minimization in putative primordial genetic codes

    Directory of Open Access Journals (Sweden)

    Koonin Eugene V

    2009-11-01

    Full Text Available Abstract Background The standard genetic code is redundant and has a highly non-random structure. Codons for the same amino acids typically differ only by the nucleotide in the third position, whereas similar amino acids are encoded, mostly, by codon series that differ by a single base substitution in the third or the first position. As a result, the code is highly albeit not optimally robust to errors of translation, a property that has been interpreted either as a product of selection directed at the minimization of errors or as a non-adaptive by-product of evolution of the code driven by other forces. Results We investigated the error-minimization properties of putative primordial codes that consisted of 16 supercodons, with the third base being completely redundant, using a previously derived cost function and the error minimization percentage as the measure of a code's robustness to mistranslation. It is shown that, when the 16-supercodon table is populated with 10 putative primordial amino acids, inferred from the results of abiotic synthesis experiments and other evidence independent of the code's evolution, and with minimal assumptions used to assign the remaining supercodons, the resulting 2-letter codes are nearly optimal in terms of the error minimization level. Conclusion The results of the computational experiments with putative primordial genetic codes that contained only two meaningful letters in all codons and encoded 10 to 16 amino acids indicate that such codes are likely to have been nearly optimal with respect to the minimization of translation errors. This near-optimality could be the outcome of extensive early selection during the co-evolution of the code with the primordial, error-prone translation system, or a result of a unique, accidental event. Under this hypothesis, the subsequent expansion of the code resulted in a decrease of the error minimization level that became sustainable owing to the evolution of a high

  2. Residential mobility microsimulation models

    Science.gov (United States)

    Wang, Yifei; Wu, Lun

    2010-09-01

    Residential mobility refers to the spatial movement of individuals and households between dwellings within an urban area. This considerable amount of intra-urban movement affects the urban structure and has significant repercussions for urban transportation. In order to understand and project related impacts, a considerable number of residential mobility models has been developed and used in the regional planning process. Within this context, the history and state-of-art residential mobility models are discussed and indicated. Meanwhile, a residential mobility Microsimulation model, called URM-Microsim (Urban Residential Mobility Microsimulation), is introduced and discussed.

  3. Mobile intention recognition

    CERN Document Server

    Kiefer, Peter

    2011-01-01

    Mobile Intention Recognition addresses problems of practical relevance for mobile system engineers: how can we make mobile assistance systems more intelligent? How can we model and recognize patterns of human behavior which span more than a limited spatial context? This text provides an overview on plan and intention recognition, ranging from the late 1970s to very recent approaches. This overview is unique as it discusses approaches with respect to the specificities of mobile intention recognition. This book covers problems from research on mobile assistance systems using methods from artific

  4. Mobile Virtual Private Networking

    Science.gov (United States)

    Pulkkis, Göran; Grahn, Kaj; Mårtens, Mathias; Mattsson, Jonny

    Mobile Virtual Private Networking (VPN) solutions based on the Internet Security Protocol (IPSec), Transport Layer Security/Secure Socket Layer (SSL/TLS), Secure Shell (SSH), 3G/GPRS cellular networks, Mobile IP, and the presently experimental Host Identity Protocol (HIP) are described, compared and evaluated. Mobile VPN solutions based on HIP are recommended for future networking because of superior processing efficiency and network capacity demand features. Mobile VPN implementation issues associated with the IP protocol versions IPv4 and IPv6 are also evaluated. Mobile VPN implementation experiences are presented and discussed.

  5. European mobility cultures

    DEFF Research Database (Denmark)

    Haustein, Sonja; Nielsen, Thomas A. Sick

    2016-01-01

    More targeted European policies promoting green travel patterns require better knowledge on differing mobility cultures across European regions. As a basis for this, we clustered the EU population into eight mobility styles based on Eurobarometer data. The mobility styles - including, for example......-economic resources. In a second step, the 28 EU member countries were clustered into six country clusters based on their representation of mobility styles. The country clusters indicate the existence of considerably different mobility cultures across the EU. Sub-regions can be identified that have highly different...

  6. Mobile Applications for Knowledge Workers and Field Workers

    Directory of Open Access Journals (Sweden)

    Stefan Stieglitz

    2015-01-01

    Full Text Available In recent years, the diffusion of mobile applications (mobile apps has risen significantly. Nowadays, mobile business apps are strongly emerging in business, enhancing productivity and employees’ satisfaction, whilst the usage of customized individual enterprise apps is still an exception. Standardized business apps enable basic functionalities, for example, mobile data storage and exchange (e.g., Dropbox, communication (e.g., Skype, and other routine processes, which support mobile workers. In addition, mobile apps can, for example, increase the flexibility of mobile workers by easing the access to firm’s information from outside the enterprise and by enabling ubiquitous collaboration. Hence, mobile apps can generate competitive advantages and can increase work efficiency on a broad scale. But mobile workers form no coherent group. Our research reveals, based on two case studies, that they can be clustered into two groups: knowledge workers and field workers. Knowledge workers and field workers fulfill different tasks and work in different environments. Hence, they have different requirements for mobile support. In this paper we conclude that standardized mobile business apps cannot meet the different requirements of various groups of mobile workers. Task- and firm-specific (individualized requirements determine the specification, implementation, and application of mobile apps.

  7. Basal ganglia calcification as a putative cause for cognitive decline

    Directory of Open Access Journals (Sweden)

    João Ricardo Mendes de Oliveira

    Full Text Available ABSTRACT Basal ganglia calcifications (BGC may be present in various medical conditions, such as infections, metabolic, psychiatric and neurological diseases, associated with different etiologies and clinical outcomes, including parkinsonism, psychosis, mood swings and dementia. A literature review was performed highlighting the main neuropsychological findings of BGC, with particular attention to clinical reports of cognitive decline. Neuroimaging studies combined with neuropsychological analysis show that some patients have shown progressive disturbances of selective attention, declarative memory and verbal perseveration. Therefore, the calcification process might represent a putative cause for dementia syndromes, suggesting a probable link among calcinosis, the aging process and eventually with neuronal death. The increasing number of reports available will foster a necessary discussion about cerebral calcinosis and its role in determining symptomatology in dementia patients

  8. Probing the putative active site of YjdL

    DEFF Research Database (Denmark)

    Jensen, Johanne Mørch; Ismat, Fouzia; Szakonyi, Gerda;

    2012-01-01

    YjdL from E. coli is an unusual proton-coupled oligopeptide transporter (POT). Unlike prototypical POTs, dipeptides are preferred over tripeptides, in particular dipeptides with a positively charged C-terminal residue. To further understand this difference in peptide specificity, the sequences...... of YjdL and YdgR, a prototypical E. coli POT, were compared in light of the crystal structure of a POT from Shewanella oneidensis. Several residues found in the putative active site were mutated and the activities of the mutated variants were assessed in terms of substrate uptake assays, and changes...... pocket that opens towards the extracellular space. The C-terminal side chain faces in the opposite direction into a sub pocket that faces the cytoplasm. These data indicated a stabilizing effect on a bulky N-terminal residue by an Ala281Phe variant and on the dipeptide backbone by Trp278...

  9. Novel putative mechanisms to link circadian clocks to healthy aging.

    Science.gov (United States)

    Popa-Wagner, Aurel; Catalin, Bogdan; Buga, Ana-Maria

    2015-08-01

    The circadian clock coordinates the internal physiology to increase the homeostatic capacity thereby providing both a survival advantage to the system and an optimization of energy budgeting. Multiple-oscillator circadian mechanisms are likely to play a role in regulating human health and may contribute to the aging process. Our aim is to give an overview of how the central clock in the hypothalamus and peripheral clocks relate to aging and metabolic disorders, including hyperlipidemia and hyperglycemia. In particular, we unravel novel putative mechanisms to link circadian clocks to healthy aging. This review may lead to the design of large-scale interventions to help people stay healthy as they age by adjusting daily activities, such as feeding behavior, and or adaptation to age-related changes in individual circadian rhythms.

  10. Putative benefits of microalgal astaxanthin on exercise and human health

    Directory of Open Access Journals (Sweden)

    Marcelo P. Barros

    2011-04-01

    Full Text Available Astaxanthin (ASTA is a pinkish-orange carotenoid produced by microalgae, but also commonly found in shrimp, lobster and salmon, which accumulate ASTA from the aquatic food chain. Numerous studies have addressed the benefits of ASTA for human health, including the inhibition of LDL oxidation, UV-photoprotection and prophylaxis of bacterial stomach ulcers. ASTA is recognized as a powerful scavenger of reactive oxygen species (ROS, especially those involved in lipid peroxidation. Both aerobic and anaerobic exercise are closely related to overproduction of ROS in muscle tissue. Post-exercise inflammatory processes can even exacerbate the oxidative stress imposed by exercise. Thus, ASTA is suggested here as a putative nutritional alternative/coadjutant for antioxidant therapy to afford additional protection to muscle tissues against oxidative damage induced by exercise, as well as for an (overall integrative redox re-balance and general human health.

  11. An Analysis of the Mobile Payment Problem in Europe

    OpenAIRE

    Pousttchi, Key

    2004-01-01

    Mobile payment is crucial for, but not limited to mobile commerce. But a role as an established payment system still seems to be a distant prospect for it. In this paper we examine the basic conditions to mobile payment with special regard to the European market. Based on this, we analyze the current deadlock on the mobile payment market in order to develop a set of requirements to an integrative solution in the form of a Universal Mobile Payment System (UMPS). Finally, applications and const...

  12. Embodied Cultures of Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.

    2010-01-01

    contemporary theorists understanding bodily movement, material sites of mobility, and social interactions must be consulted along the road (e.g. Latour’s work on objects and ANT, Thrift’s work on the body and ‘non-representational theory, and Massumi’s notions of affects and emotions related to bodily mobility......The paper explores the relationship between the body and mobility by looking into a number of modes of transportation and their ways of constructing particular engagements with mobility. The ‘mobile embodiments’ are significant to a material and symbolic set of relations between human agents...... and material artifacts. The paper target the complex relationship between the moving, sensing body and the material and built environment of infrastructures and mobility modes in order to explore what norms, and meanings, and everyday life mobility cultures are being produced and re-produced in this process...

  13. Engaging with mobile methods

    DEFF Research Database (Denmark)

    Jensen, Martin Trandberg

    2014-01-01

    This chapter showcases how mobile methods are more than calibrated techniques awaiting application by tourism researchers, but productive in the enactment of the mobile (Law and Urry, 2004). Drawing upon recent findings deriving from a PhD course on mobility and mobile methods it reveals...... the conceptual ambiguousness of the term ‘mobile methods’. In order to explore this ambiguousness the chapter provides a number of examples deriving from tourism research, to explore how mobile methods are always entangled in ideologies, predispositions, conventions and practice-realities. Accordingly......, the engagements with methods are acknowledged to be always political and contextual, reminding us to avoid essentialist discussions regarding research methods. Finally, the chapter draws on recent fieldwork to extend developments in mobilities-oriented tourism research, by employing auto-ethnography to call...

  14. Cryptic species in putative ancient asexual darwinulids (Crustacea, Ostracoda.

    Directory of Open Access Journals (Sweden)

    Isa Schön

    Full Text Available BACKGROUND: Fully asexually reproducing taxa lack outcrossing. Hence, the classic Biological Species Concept cannot be applied. METHODOLOGY/PRINCIPAL FINDINGS: We used DNA sequences from the mitochondrial COI gene and the nuclear ITS2 region to check species boundaries according to the evolutionary genetic (EG species concept in five morphospecies in the putative ancient asexual ostracod genera, Penthesilenula and Darwinula, from different continents. We applied two methods for detecting cryptic species, namely the K/θ method and the General Mixed Yule Coalescent model (GMYC. We could confirm the existence of species in all five darwinulid morphospecies and additional cryptic diversity in three morphospecies, namely in Penthesilenula brasiliensis, Darwinula stevensoni and in P. aotearoa. The number of cryptic species within one morphospecies varied between seven (P. brasiliensis, five to six (D. stevensoni and two (P. aotearoa, respectively, depending on the method used. Cryptic species mainly followed continental distributions. We also found evidence for coexistence at the local scale for Brazilian cryptic species of P. brasiliensis and P. aotearoa. Our ITS2 data confirmed that species exist in darwinulids but detected far less EG species, namely two to three cryptic species in P. brasiliensis and no cryptic species at all in the other darwinulid morphospecies. CONCLUSIONS/SIGNIFICANCE: Our results clearly demonstrate that both species and cryptic diversity can be recognized in putative ancient asexual ostracods using the EG species concept, and that COI data are more suitable than ITS2 for this purpose. The discovery of up to eight cryptic species within a single morphospecies will significantly increase estimates of biodiversity in this asexual ostracod group. Which factors, other than long-term geographic isolation, are important for speciation processes in these ancient asexuals remains to be investigated.

  15. Putative regulatory factors associated with intramuscular fat content.

    Directory of Open Access Journals (Sweden)

    Aline S M Cesar

    Full Text Available Intramuscular fat (IMF content is related to insulin resistance, which is an important prediction factor for disorders, such as cardiovascular disease, obesity and type 2 diabetes in human. At the same time, it is an economically important trait, which influences the sensorial and nutritional value of meat. The deposition of IMF is influenced by many factors such as sex, age, nutrition, and genetics. In this study Nellore steers (Bos taurus indicus subspecies were used to better understand the molecular mechanisms involved in IMF content. This was accomplished by identifying differentially expressed genes (DEG, biological pathways and putative regulatory factors. Animals included in this study had extreme genomic estimated breeding value (GEBV for IMF. RNA-seq analysis, gene set enrichment analysis (GSEA and co-expression network methods, such as partial correlation coefficient with information theory (PCIT, regulatory impact factor (RIF and phenotypic impact factor (PIF were utilized to better understand intramuscular adipogenesis. A total of 16,101 genes were analyzed in both groups (high (H and low (L GEBV and 77 DEG (FDR 10% were identified between the two groups. Pathway Studio software identified 13 significantly over-represented pathways, functional classes and small molecule signaling pathways within the DEG list. PCIT analyses identified genes with a difference in the number of gene-gene correlations between H and L group and detected putative regulatory factors involved in IMF content. Candidate genes identified by PCIT include: ANKRD26, HOXC5 and PPAPDC2. RIF and PIF analyses identified several candidate genes: GLI2 and IGF2 (RIF1, MPC1 and UBL5 (RIF2 and a host of small RNAs, including miR-1281 (PIF. These findings contribute to a better understanding of the molecular mechanisms that underlie fat content and energy balance in muscle and provide important information for the production of healthier beef for human consumption.

  16. MobilED – a mobile tools and services platform for formal and informal learning

    CSIR Research Space (South Africa)

    Ford, M

    2006-10-01

    Full Text Available The MobilED initiative is aimed at designing teaching and learning environments that are meaningfully enhanced with mobile technologies and services. The MobilED deliverables are to develop a set of scenarios and guidelines of how mobile...

  17. 33 CFR 165.835 - Security Zone; Port of Mobile, Mobile Ship Channel, Mobile, AL.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone; Port of Mobile, Mobile Ship Channel, Mobile, AL. 165.835 Section 165.835 Navigation and Navigable Waters COAST GUARD... § 165.835 Security Zone; Port of Mobile, Mobile Ship Channel, Mobile, AL. (a) Definition. As used...

  18. Robonaut Mobile Autonomy: Initial Experiments

    Science.gov (United States)

    Diftler, M. A.; Ambrose, R. O.; Goza, S. M.; Tyree, K. S.; Huber, E. L.

    2006-01-01

    A mobile version of the NASA/DARPA Robonaut humanoid recently completed initial autonomy trials working directly with humans in cluttered environments. This compact robot combines the upper body of the Robonaut system with a Segway Robotic Mobility Platform yielding a dexterous, maneuverable humanoid ideal for interacting with human co-workers in a range of environments. This system uses stereovision to locate human teammates and tools and a navigation system that uses laser range and vision data to follow humans while avoiding obstacles. Tactile sensors provide information to grasping algorithms for efficient tool exchanges. The autonomous architecture utilizes these pre-programmed skills to form complex behaviors. The initial behavior demonstrates a robust capability to assist a human by acquiring a tool from a remotely located individual and then following the human in a cluttered environment with the tool for future use.

  19. Content Sharing for Mobile Devices

    CERN Document Server

    Ball, Rudi

    2008-01-01

    The miniaturisation of computing devices has seen computing devices become increasingly pervasive in society. With this increased pervasiveness, the technologies of small computing devices have also improved. Mobile devices are now capable of capturing various forms of multimedia and able to communicate wirelessly using increasing numbers of communication techniques. The owners and creators of local content are motivated to share this content in ever increasing volume; the conclusion has been that social networks sites are seeing a revolution in the sharing of information between communities of people. As load on centralised systems increases, we present a novel decentralised peer-to-peer approach dubbed the Market Contact Protocol (MCP) to achieve cost effective, scalable and efficient content sharing using opportunistic networking (pocket switched networking), incentive, context-awareness, social contact and mobile devices. Within the report we describe how the MCP is simulated with a superimposed geographi...

  20. CERN Mobility Survey

    CERN Multimedia

    GS Department

    2011-01-01

    The Institute of Shipping and Transport of the University of the Aegean and the National Technical University of Athens are partners with CERN in a study of mobility patterns between and within the CERN sites and to that effect have realized a mobility survey dedicated to the CERN community.         The study aims to understand: How you presently get around the CERN sites; What problems you encounter regarding mobility; What your needs are; What improvements you’d like to see; What measures you would like to see implemented most. The replies we receive will enable us to define a general policy promoting the diversity of mobility at CERN and to establish and quantify the strategic actions to be implemented for both the short and medium term. The objectives of the transport mobility plans are to: Facilitate mobility within and between the CERN sites by identifying adequate solutions in response to individual ...

  1. Making Everyday Mobility

    DEFF Research Database (Denmark)

    Wind, Simon

    practices. Specific heterogeneous configurations in mobility practices facilitate instrumental movement of family members, but can also engender care, quality time of togetherness, recreational and productive in-betweens, as well as sensorial and emotional experiences through the orchestration of affective......Based upon a qualitative PhD study of 11 families everyday mobility, this paper inquiries into the everyday mobility of families with children in the Greater Copenhagen Area and the role mobility plays in contributing to coping in the families’ everyday life. Drawing on Mobilities theory (Jensen...... 2013; Urry 2007) and family theory (Holdsworth 2013; Morgan 2011), it is argued that family mobility is far from only an instrumental phenomenon, displacing family members back and forth between activities and doings, but also a type of family practice (Morgan, 2011) carrying social and emotional...

  2. Understanding pastoral mobility

    DEFF Research Database (Denmark)

    Adriansen, Hanne Kirstine

    2008-01-01

    Based on a case study from Sahelian Senegal, this paper analyses how various actors perceive the importance of pastoral mobility and presents issues of importance for understanding the use of mobility among Fulani of Ferlo. One knowledge system is a scientific one, the 'new rangeland paradigm......'. According to this, pastoral mobility is a means to balance variability in dryland resources; hence, 'nature' is the point of departure. Another knowledge system is local pastoral knowledge. For the pastoralists, the well-being of their animals is the point of departure and mobility is used to ensure...... that the livestock are in good condition. The paper shows that it is important to distinguish between mobility of pastoralists and of their herd; even though the pastoralists of northern Senegal have become semi-sedentary, their herds are still quite mobile. The pastoralists are willing to move around within a small...

  3. SOD FORM OF PERENNIAL GRASSES

    OpenAIRE

    Belyuchenko I. S.

    2014-01-01

    The article considers the peculiarities of turf and sod, specificity of formation of kidneys for regeneration, types of shoots, vegetative mobility and specificity of growth in certain conditions, turf grasses are divided into loosely-and tightly-turf characterized, by specific features of environmental, biological characteristics; forming turf from generative rosettes, elongated and shortened vegetative, side ground shoots, differing specificity of morphological, biochemical and fitocoenotic...

  4. Mobile learning in medicine

    Science.gov (United States)

    Serkan Güllüoüǧlu, Sabri

    2013-03-01

    This paper outlines the main infrastructure for implicating mobile learning in medicine and present a sample mobile learning application for medical learning within the framework of mobile learning systems. Mobile technology is developing nowadays. In this case it will be useful to develop different learning environments using these innovations in internet based distance education. M-learning makes the most of being on location, providing immediate access, being connected, and acknowledges learning that occurs beyond formal learning settings, in places such as the workplace, home, and outdoors. Central to m-learning is the principle that it is the learner who is mobile rather than the device used to deliver m learning. The integration of mobile technologies into training has made learning more accessible and portable. Mobile technologies make it possible for a learner to have access to a computer and subsequently learning material and activities; at any time and in any place. Mobile devices can include: mobile phone, personal digital assistants (PDAs), personal digital media players (eg iPods, MP3 players), portable digital media players, portable digital multimedia players. Mobile learning (m-learning) is particularly important in medical education, and the major users of mobile devices are in the field of medicine. The contexts and environment in which learning occurs necessitates m-learning. Medical students are placed in hospital/clinical settings very early in training and require access to course information and to record and reflect on their experiences while on the move. As a result of this paper, this paper strives to compare and contrast mobile learning with normal learning in medicine from various perspectives and give insights and advises into the essential characteristics of both for sustaining medical education.

  5. Mobility decline in old age

    DEFF Research Database (Denmark)

    Rantakokko, Merja; Mänty, Minna Regina; Rantanen, Taina

    2013-01-01

    Mobility is important for community independence. With increasing age, underlying pathologies, genetic vulnerabilities, physiological and sensory impairments, and environmental barriers increase the risk for mobility decline. Understanding how mobility declines is paramount to finding ways to pro...... to promote mobility in old age.......Mobility is important for community independence. With increasing age, underlying pathologies, genetic vulnerabilities, physiological and sensory impairments, and environmental barriers increase the risk for mobility decline. Understanding how mobility declines is paramount to finding ways...

  6. Exploring the mobility of mobile phone users

    Science.gov (United States)

    Csáji, Balázs Cs.; Browet, Arnaud; Traag, V. A.; Delvenne, Jean-Charles; Huens, Etienne; Van Dooren, Paul; Smoreda, Zbigniew; Blondel, Vincent D.

    2013-03-01

    Mobile phone datasets allow for the analysis of human behavior on an unprecedented scale. The social network, temporal dynamics and mobile behavior of mobile phone users have often been analyzed independently from each other using mobile phone datasets. In this article, we explore the connections between various features of human behavior extracted from a large mobile phone dataset. Our observations are based on the analysis of communication data of 100,000 anonymized and randomly chosen individuals in a dataset of communications in Portugal. We show that clustering and principal component analysis allow for a significant dimension reduction with limited loss of information. The most important features are related to geographical location. In particular, we observe that most people spend most of their time at only a few locations. With the help of clustering methods, we then robustly identify home and office locations and compare the results with official census data. Finally, we analyze the geographic spread of users’ frequent locations and show that commuting distances can be reasonably well explained by a gravity model.

  7. Mobile networks and computing

    CERN Document Server

    Rajasekaran, Sanguthevar; Hsu, D Frank

    2000-01-01

    Advances in the technologies of networking, wireless communications, and miniaturization of computers have lead to rapid development in mobile communication infrastructure and have engendered a new paradigm of computing. Users carrying portable devices can now move freely about while remaining connected to the network. This "portability" allows for access to information from anywhere and at any time. The flexibility has resulted in new levels of complexity not encountered previously in software and protocol design for wired networking. New challenges in designing software systems for mobile networks include location and mobility management, channel allocation, power conservation, and more. In this book, renowned researchers in the field address these aspects of mobile networking.

  8. Mobile Solar Tracker Facility

    Data.gov (United States)

    Federal Laboratory Consortium — NIST's mobile solar tracking facility is used to characterize the electrical performance of photovoltaic panels. It incorporates meteorological instruments, a solar...

  9. Mobile Test Capabilities

    Data.gov (United States)

    Federal Laboratory Consortium — The Electrical Power Mobile Test capabilities are utilized to conduct electrical power quality testing on aircraft and helicopters. This capability allows that the...

  10. Practical mobile forensics

    CERN Document Server

    Bommisetty, Satish; Mahalik, Heather

    2014-01-01

    The book is an easy-to-follow guide with clear instructions on various mobile forensic techniques. The chapters and the topics within are structured for a smooth learning curve, which will swiftly empower you to master mobile forensics. If you are a budding forensic analyst, consultant, engineer, or a forensic professional wanting to expand your skillset, this is the book for you. The book will also be beneficial to those with an interest in mobile forensics or wanting to find data lost on mobile devices. It will be helpful to be familiar with forensics in general but no prior experience is re

  11. The Mobilization Methods

    Science.gov (United States)

    Manpower Research Visibility, 1973

    1973-01-01

    Approaches to training hard-to-employ'' populations by the Mobilization for Youth Experimental Manpower Laboratory. Manpower Research Visibility is a supplement to American Vocational Journal. (Editor)

  12. Guest Editorial ~ Mobile Learning

    Directory of Open Access Journals (Sweden)

    Mohamed Ally

    2007-06-01

    Full Text Available This special IRRODL issue on mobile learning is timely because of the proliferation of mobile technology in society, globalization, and the need to re-examine how learning materials are designed and delivered for the new generation of learners. In today’s world, people are on the move and are demanding access to learning materials and information anytime and anywhere. At the same time, there is increasing use of mobile technology in different sectors of society to meet the needs of people on the move. In business, there is increasing use of mobile technologies for individuals to conduct their business anywhere and anytime. In healthcare, medical staff are using mobile technologies to access just-in-time information and to enter information in real time. People working in the field away from the central office use mobile technologies to access information and to communicate with other workers. Also, younger generations of learners are using mobile technologies for entertainment and socialization. These learners are using mobile devices to access information and multimedia materials and to communicate with friends. These new generations of learners do not see technology as something foreign. They readily accept technology and consider technology to be part of their lives. Moreover, the use of mobile technology is a 21st Century skill that students and workers must have to function in society.

  13. Mobile Project Management

    Directory of Open Access Journals (Sweden)

    Catalin BOJA

    2006-01-01

    Full Text Available Based on the development of new communication and data transfer technologies, the mobile solutions for the management process have been able to provide new ways to conduct management actions. This environment describes methods and tools available only here, which will bring information, speed and efficiency to any stage and component of the management process. The paper takes into discussion the impact of the technological development on the management process paradigm. The paper presents the main aspects regarding the business and management models used in mobile management. The role of mobile multimedia informatics applications in mobile management is highlighted.

  14. Programming the Mobile Web

    CERN Document Server

    Firtman, Maximiliano

    2010-01-01

    Today's market for mobile apps goes beyond the iPhone to include BlackBerry, Nokia, Windows Phone, and smartphones powered by Android, webOS, and other platforms. If you're an experienced web developer, this book shows you how to build a standard app core that you can extend to work with specific devices. You'll learn the particulars and pitfalls of building mobile apps with HTML, CSS, and other standard web tools. You'll also explore platform variations, finicky mobile browsers, Ajax design patterns for mobile, and much more. Before you know it, you'll be able to create mashups using Web 2.

  15. Mobile computing handbook

    CERN Document Server

    Ilyas, Mohammad

    2004-01-01

    INTRODUCTION AND APPLICATIONS OF MOBILE COMPUTING Wearable Computing,A. Smailagic and D.P. Siewiorek Developing Mobile Applications: A Lime Primer,G.P. Picco, A.L. Murphy, and G.-C. Roman Pervasive Application Development: Approaches and Pitfalls,G. Banavar, N. Cohen, and D. Soroker ISAM, Joining Context-Awareness and Mobility to Building Pervasive Applications,I. Augustin, A. Corrêa Yamin, J.L. Victória Barbosa, L. Cavalheiro da Silva, R. Araújo Real, G. Frainer, G.G. Honrich Cavalheiro, and C.F. Resin Geyer Integrating Mobile Wireless Devices into the Computational Grid,T. Phan, L. Huan

  16. Proxemic Mobile Collocated Interactions

    DEFF Research Database (Denmark)

    Porcheron, Martin; Lucero, Andrés; Quigley, Aaron

    2016-01-01

    and their digital devices (i.e. the proxemic relationships). Building on the ideas of proxemic interactions, this workshop is motivated by the concept of ‘proxemic mobile collocated interactions’, to harness new or existing technologies to create engaging and interactionally relevant experiences. Such approaches......Recent research on mobile collocated interactions has been looking at situations in which collocated users engage in collaborative activities using their mobile devices. However, existing practices fail to fully account for the culturally-dependent spatial relationships between people...... in exploring proxemics and mobile collocated interactions....

  17. The setup of a mobile mobility panel for the Netherlands

    NARCIS (Netherlands)

    Geurs, K.T.; Veenstra, S.A.; Thomas, T.

    2013-01-01

    This paper describes the setup of the Dutch Mobile Mobility Panel project, in which GPS-enabled mobile phones (smartphones) are used as a passive multiple-week and multiple-year travel behaviour data collection tool. The data collection methodology used in the Dutch Mobile Mobility Panel comprised f

  18. Mobile lifestyles : Conceptualizing heterogeneity in mobile youth culture

    NARCIS (Netherlands)

    Vanden Abeele, M.M.P.

    2014-01-01

    Adolescents’ characteristic understanding and use of mobile phones have led observers to speak of a “mobile youth culture.” This article explores whether we can differentiate lifestyles within mobile youth culture. We construct a user typology of Flemish adolescent mobile phone users based on mobile

  19. Mobile lifestyles : Conceptualizing heterogeneity in mobile youth culture

    NARCIS (Netherlands)

    Vanden Abeele, M.M.P.

    2014-01-01

    Adolescents’ characteristic understanding and use of mobile phones have led observers to speak of a “mobile youth culture.” This article explores whether we can differentiate lifestyles within mobile youth culture. We construct a user typology of Flemish adolescent mobile phone users based on mobile

  20. The Use and Perception of Mobility among Senegalese Fulani

    DEFF Research Database (Denmark)

    Adriansen, Hanne Kirstine

    and the cultural construction of identity, the shaping of space into place, the influence of commercialisation on mobility, and quantitative and spatial assessments of mobility. In combination with aspects of the ‘new rangeland paradigm’ these form the ‘mobility complex’, which is suggested as an analytical tool......According to the ‘new rangeland paradigm’, which developed in the early 1990s, pastoral mobility is a flexible strategy that balances the variability in natural resources. Today this view is widely acknowledged. However, in order to understand future dynamics of the pastoral way of life......, the pastoralists’ own perceptions of mobility need to be understood. Furthermore, pastoral mobility should be studied in the broader context of livelihood strategies. The purpose of this paper is to provide a more comprehensive understanding of pastoral mobility than the one offered by the ‘new rangeland paradigm...

  1. Mobile multimedia understanding applications: an overview

    Science.gov (United States)

    Lin, Xiaofan

    2011-03-01

    In recent years, mobile devices are quickly reaching almost every corner of our daily life in a variety of forms: personal media players, smart phones, netbooks, and tablets. Besides the more powerful, smaller, and more versatile hardware, another driving force is the vast number of software applications ("apps") on those mobile devices. A number of mobile apps employ intelligent multimedia understanding (MU) technologies. This paper gives an overview of such apps. The focus is not on the underlying MU techniques, which are already covered by a huge amount of literature. Instead, it attempts to shed some light on the junction of mobile apps and MU. For this purpose, it addresses a number of important aspects: unique requirements and characteristics of MU-related apps, values brought in by MU, typical MU technologies, various system architectures, available development tools, and related standards.

  2. Putative uremic encephalopathy in horses: five cases (1978-1998).

    Science.gov (United States)

    Frye, M A; Johnson, J S; Traub-Dargatz, J L; Savage, C J; Fettman, M J; Gould, D H

    2001-02-15

    To determine historical, physical examination, clinicopathologic, and postmortem findings in horses with putative uremic encephalopathy. Design-Retrospective study. Animals-5 horses with renal failure and neurologic disease not attributable to abnormalities in any other organ system. Medical records from 1978 to 1998 were examined for horses with renal disease and neurologic signs not attributable to primary neurologic, hepatic, or other diseases. Signalment, history, physical examination findings, clinicopathologic data, renal ultrasonographic findings, and postmortem data were reviewed. Of 332 horses with renal disease, 5 met selection criteria. Historical findings, physical examination findings, clinicopathologic data, ultrasonographic data, and postmortem findings were consistent with chronic renal failure. Swollen astrocytes were detected in all 4 horses examined at necropsy. A single criterion was not determined to be pathognomonic for uremic encephalopathy in horses. Uremic encephalopathy should be considered as a differential diagnosis in horses with evidence of chronic renal failure and encephalopathic neurologic sign not attributable to other causes. Astrocyte swelling, which was common to all 4 horses examined at necropsy, may serve as a microscopic indicator of uremic encephalopathy in horses.

  3. Phytophthora infestans specific phosphorylation patterns and new putative control targets.

    Science.gov (United States)

    Frades, Itziar; Andreasson, Erik

    2016-04-01

    In this study we applied biomathematical searches of gene regulatory mechanisms to learn more about oomycete biology and to identify new putative targets for pesticides or biological control against Phytophthora infestans. First, oomycete phylum-specific phosphorylation motifs were found by discriminative n-gram analysis. We found 11.600 P. infestans specific n-grams, mapping 642 phosphoproteins. The most abundant group among these related to phosphatidylinositol metabolism. Due to the large number of possible targets found and our hypothesis that multi-level control is a sign of usefulness as targets for intervention, we identified overlapping targets with a second screen. This was performed to identify proteins dually regulated by small RNA and phosphorylation. We found 164 proteins to be regulated by both sRNA and phosphorylation and the dominating functions where phosphatidylinositol signalling/metabolism, endocytosis, and autophagy. Furthermore we performed a similar regulatory study and discriminative n-gram analysis of proteins with no clear orthologs in other species and proteins that are known to be unique to P. infestans such as the RxLR effectors, Crinkler (CRN) proteins and elicitins. We identified CRN proteins with specific phospho-motifs present in all life stages. PITG_12626, PITG_14042 and PITG_23175 are CRN proteins that have species-specific phosphorylation motifs and are subject to dual regulation.

  4. Rapid Discrimination Among Putative Mechanistic Models of Biochemical Systems.

    Science.gov (United States)

    Lomnitz, Jason G; Savageau, Michael A

    2016-08-31

    An overarching goal in molecular biology is to gain an understanding of the mechanistic basis underlying biochemical systems. Success is critical if we are to predict effectively the outcome of drug treatments and the development of abnormal phenotypes. However, data from most experimental studies is typically noisy and sparse. This allows multiple potential mechanisms to account for experimental observations, and often devising experiments to test each is not feasible. Here, we introduce a novel strategy that discriminates among putative models based on their repertoire of qualitatively distinct phenotypes, without relying on knowledge of specific values for rate constants and binding constants. As an illustration, we apply this strategy to two synthetic gene circuits exhibiting anomalous behaviors. Our results show that the conventional models, based on their well-characterized components, cannot account for the experimental observations. We examine a total of 40 alternative hypotheses and show that only 5 have the potential to reproduce the experimental data, and one can do so with biologically relevant parameter values.

  5. Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene

    Directory of Open Access Journals (Sweden)

    Cheryl K. Zogg

    2014-01-01

    Full Text Available Exemplified by cancer cells’ preference for glycolysis, for example, the Warburg effect, altered metabolism in tumorigenesis has emerged as an important aspect of cancer in the past 10–20 years. Whether due to changes in regulatory tumor suppressors/oncogenes or by acting as metabolic oncogenes themselves, enzymes involved in the complex network of metabolic pathways are being studied to understand their role and assess their utility as therapeutic targets. Conversion of glycolytic intermediate 3-phosphoglycerate into phosphohydroxypyruvate by the enzyme phosphoglycerate dehydrogenase (PHGDH—a rate-limiting step in the conversion of 3-phosphoglycerate to serine—represents one such mechanism. Forgotten since classic animal studies in the 1980s, the role of PHGDH as a potential therapeutic target and putative metabolic oncogene has recently reemerged following publication of two prominent papers near-simultaneously in 2011. Since that time, numerous studies and a host of metabolic explanations have been put forward in an attempt to understand the results observed. In this paper, I review the historic progression of our understanding of the role of PHGDH in cancer from the early work by Snell through its reemergence and rise to prominence, culminating in an assessment of subsequent work and what it means for the future of PHGDH.

  6. Small intestinal mucosa expression of putative chaperone fls485

    Directory of Open Access Journals (Sweden)

    Raupach Kerstin

    2010-03-01

    Full Text Available Abstract Background Maturation of enterocytes along the small intestinal crypt-villus axis is associated with significant changes in gene expression profiles. fls485 coding a putative chaperone protein has been recently suggested as a gene involved in this process. The aim of the present study was to analyze fls485 expression in human small intestinal mucosa. Methods fls485 expression in purified normal or intestinal mucosa affected with celiac disease was investigated with a molecular approach including qRT-PCR, Western blotting, and expression strategies. Molecular data were corroborated with several in situ techniques and usage of newly synthesized mouse monoclonal antibodies. Results fls485 mRNA expression was preferentially found in enterocytes and chromaffine cells of human intestinal mucosa as well as in several cell lines including Rko, Lovo, and CaCo2 cells. Western blot analysis with our new anti-fls485 antibodies revealed at least two fls485 proteins. In a functional CaCo2 model, an increase in fls485 expression was paralleled by cellular maturation stage. Immunohistochemistry demonstrated fls485 as a cytosolic protein with a slightly increasing expression gradient along the crypt-villus axis which was impaired in celiac disease Marsh IIIa-c. Conclusions Expression and synthesis of fls485 are found in surface lining epithelia of normal human intestinal mucosa and deriving epithelial cell lines. An interdependence of enterocyte differentiation along the crypt-villus axis and fls485 chaperone activity might be possible.

  7. Small intestinal mucosa expression of putative chaperone fls485.

    Science.gov (United States)

    Reinartz, Andrea; Ehling, Josef; Franz, Susanne; Simon, Verena; Bravo, Ignacio G; Tessmer, Claudia; Zentgraf, Hanswalter; Lyer, Stefan; Schneider, Ursula; Köster, Jan; Raupach, Kerstin; Kämmerer, Elke; Klaus, Christina; Tischendorf, Jens J W; Kopitz, Jürgen; Alonso, Angel; Gassler, Nikolaus

    2010-03-07

    Maturation of enterocytes along the small intestinal crypt-villus axis is associated with significant changes in gene expression profiles. fls485 coding a putative chaperone protein has been recently suggested as a gene involved in this process. The aim of the present study was to analyze fls485 expression in human small intestinal mucosa. fls485 expression in purified normal or intestinal mucosa affected with celiac disease was investigated with a molecular approach including qRT-PCR, Western blotting, and expression strategies. Molecular data were corroborated with several in situ techniques and usage of newly synthesized mouse monoclonal antibodies. fls485 mRNA expression was preferentially found in enterocytes and chromaffine cells of human intestinal mucosa as well as in several cell lines including Rko, Lovo, and CaCo2 cells. Western blot analysis with our new anti-fls485 antibodies revealed at least two fls485 proteins. In a functional CaCo2 model, an increase in fls485 expression was paralleled by cellular maturation stage. Immunohistochemistry demonstrated fls485 as a cytosolic protein with a slightly increasing expression gradient along the crypt-villus axis which was impaired in celiac disease Marsh IIIa-c. Expression and synthesis of fls485 are found in surface lining epithelia of normal human intestinal mucosa and deriving epithelial cell lines. An interdependence of enterocyte differentiation along the crypt-villus axis and fls485 chaperone activity might be possible.

  8. Putative impact of RNA editing on drug discovery.

    Science.gov (United States)

    Decher, Niels; Netter, Michael F; Streit, Anne K

    2013-01-01

    Virtually all organisms use RNA editing as a powerful post-transcriptional mechanism to recode genomic information and to increase functional protein diversity. The enzymatic editing of pre-mRNA by ADARs and CDARs is known to change the functional properties of neuronal receptors and ion channels regulating cellular excitability. However, RNA editing is also an important mechanism for genes expressed outside the brain. The fact that RNA editing breaks the 'one gene encodes one protein' hypothesis is daunting for scientists and a probable drawback for drug development, as scientists might search for drugs targeting the 'wrong' protein. This possible difficulty for drug discovery and development became more evident from recent publications, describing that RNA editing events have profound impact on the pharmacology of some common drug targets. These recent studies highlight that RNA editing can cause massive discrepancies between the in vitro and in vivo pharmacology. Here, we review the putative impact of RNA editing on drug discovery, as RNA editing has to be considered before using high-throughput screens, rational drug design or choosing the right model organism for target validation.

  9. Epigenetic regulation of putative tumor suppressor TGFBI in human leukemias

    Institute of Scientific and Technical Information of China (English)

    Fang Hongbo; Liu Jing; Guo Dan; Liu Peixiang; Zhao Yongliang

    2014-01-01

    Background Both in vitro and in vivo data have demonstrated the TGFBI gene functions as a putative tumor suppressor and is frequently downregulated in human tumors of different histological types.The hypermethylation of the TGFBI promoter,as one of the main regulatory mechanisms,is associated with TGFBI silencing.In this study,we used a methylation-specific PCR (MSP) method to evaluate the methylation status of the TGFBI promoter in human leukemias.Methods Real-time RT-PCR and methylation-specific PCR approaches were performed to define the TGFBI expression and promoter methylation in human leukemia call lines and clinical samples.Genomic DNA was isolated from peripheral blood mononuclear cells from leukemia patients,bisulfite-converted,and analyzed by the MSP method.Results Hypermethylation of the TGFBI promoter occurred in leukemia cell lines and demethylation treatment reexpressed TGFBI at a substantially increased level in most of leukemia cell lines tested.Furthermore,a much higher level of CpG island methylation and a significantly lower TGFBI expression were also identified in clinical leukemia samples.Conclusion The results suggest an important role of promoter methylation in regulating TGFBI expression in leukemia,which provides a useful diagnostic marker for clinical management of human leukemias.

  10. Expression and characterization of rice putative PAUSED gene

    Institute of Scientific and Technical Information of China (English)

    Chengguo Yao; Liangfa Ge; Wei Li; Botao Zhao; Chaoqun Li; Kangcheng Ruan; Hongxuan Lin; Youxin Jin

    2008-01-01

    In Arab idopsis, PA USED ( PSD ) encodes the ortholog of loslp/ exportin-t, which mediates the nuclear export of transfer RNA (tRNA) in yeast and mammals. However, in monocot plants such as rice, knowledge of the corresponding ortholog is limited, and its effects on growth development and productivity remain unknown. In this study, we verified a rice transfer-DNA insertional mutantpsd line and analyzed its phenotypes;the mutant displayed severe morphological defects including retarded development and low fertility compared with wild-type rice. Examining intronless tRNA-Tyr and intron-containing pre-tRNA-Ala expression levels in cytoplasmic and nuclear fraction with Northern blot analysis between wild -type and mutant leaf tissue suggested that rice PSD might be involved in tRNA export from the nucleus to the cytoplasm.Additionally, reverse transcription-polymerase chain reaction analysis revealed that PSD transcript was expressed throughout normal rice plant development, and subcellular localization assays showed that rice PSD protein was present in both the nucleus and cytoplasm. In summary, our data implied that the putative PSD gene might be indispensable for normal rice development and its function might be the same as that ofArabidopsis PSD.

  11. Conformational study of a putative HLTV-1 retroviral protease inhibitor.

    Science.gov (United States)

    Llido, S; d'Estaintot, B L; Dautant, A; Geoffre, S; Picard, P; Precigoux, G

    1993-05-01

    The crystal structure of prolyl-glutaminyl-valyl-statyl-alanyl-leucine (Pro-Gln-Val-Sta-Ala-Leu, C(32)H(57)N(7)0(9).5H(2)0, M(r) = 683.9 + 90.1), a putative HTLV-1 protease inhibitor based on one of the consensus retroviral protease cleavage sequences, and containing the statine residue [(4S,3S)-4-amino-3-hydroxy-6-methylheptanoic acid], has been determined by X-ray diffraction. The same molecule has been modelled in the active site of the HTLV-1 protease and both conformations have been compared. The peptide crystallizes as a pentahydrate in space group P2(1) with a = 10.874(2), b = 9.501(2), c = 21.062(5) A, beta = 103.68 (1) degrees, Z = 2, V= 2114.3 A(3), D(x) = 1.21 g cm(-3), micro = 8.02 cm(-1), T= 293 K, lambda(Cu Kalpha) = 1.5418 A. The structure has been refined to an R value of 0.070 for 2152 observed reflections. The peptide main chain can be described as extended and adopts the usual zigzag conformation from the prolyl to the statyl residue. The main difference in conformation between the individual observed and modelled molecules is located on the Sta, Ala and Leu residues with the main chain of the modelled molecule rotated by about 180 degrees as compared to the observed conformation in the crystal state.

  12. Predictors of Social Mobilization Speed

    CERN Document Server

    Alstott, Jeff; Velu, Chander

    2013-01-01

    Mobilization across social networks is becoming increasingly influential, but little is known about what traits of individuals and their relationships affect their speed of mobilization between them. We ran a global social mobilization contest and recorded personal traits of the participants and those they mobilized. We examined how those traits influenced the speed of mobilization. Individuals mobilized faster when they heard about the contest directly from the contest organization, and decreased in speed when hearing from less personal source types (e.g. family vs. media). Mobilization was faster when the mobilizer and the mobilized heard about the contest through the same source type, and slower when both individuals were in different countries. Females mobilized other females faster than males mobilized other males. Mobilization was faster with young recruiters and old recruits, and slower with old recruiters and young recruits. These findings suggest ways to optimize the speed of social mobilization.

  13. MstX and a putative potassium channel facilitate biofilm formation in Bacillus subtilis.

    Directory of Open Access Journals (Sweden)

    Matthew E Lundberg

    Full Text Available Biofilms constitute the predominant form of microbial life and a potent reservoir for innate antibiotic resistance in systemic infections. In the spore-forming bacterium Bacillus subtilis, the transition from a planktonic to sessile state is mediated by mutually exclusive regulatory pathways controlling the expression of genes required for flagellum or biofilm formation. Here, we identify mstX and yugO as novel regulators of biofilm formation in B. subtilis. We show that expression of mstX and the downstream putative K+ efflux channel, yugO, is necessary for biofilm development in B. subtilis, and that overexpression of mstX induces biofilm assembly. Transcription of the mstX-yugO operon is under the negative regulation of SinR, a transcription factor that governs the switch between planktonic and sessile states. Furthermore, mstX regulates the activity of Spo0A through a positive autoregulatory loop involving KinC, a histidine kinase that is activated by potassium leakage. The addition of potassium abrogated mstX-mediated biofilm formation. Our findings expand the role of Spo0A and potassium homeostasis in the regulation of bacterial development.

  14. Tidal Forms

    Science.gov (United States)

    Bolla Pittaluga, M.; Seminara, G.; Tambroni, N.

    2003-04-01

    We give an overview of some recent investigations on the mechanics of the processes whereby forms develop in tidal environments. The viewpoint taken here is mechanistic. Some of the questions which deserve an answer may be summarised as follows: i) do tidal channels tend to some altimetric long term equilibrium? ii) why are they typically convergent and weakly meandering? iii) how is such equilibrium affected by the hydrodynamics and morphodynamics of tidal inlets? iv) what is the hydrodynamic and morphodynamic role played by tidal flats adjacent to the channels? Some of the above questions have received a considerable attention in the last few years. Schuttelaars and de Swart (1996), Lanzoni and Seminara (2002) and, more recently, Bolla Pittaluga (2003) have investigated the first problem. In particular, the latter two contributions have shown that a straight tidal channel connected to a tidal sea at one end and closed at the other end tends to reach a long term equilibrium profile, which is slightly concave seaward and convex landward where a beach forms. The equilibrium profile is strongly sensitive to the harmonic content of the tidal forcing as well as to the value of sediment concentration established by the coastal hydrodynamics in the far field of the inlet region. Less important are the effect of channel convergence and the role of settling lag in the transport of suspended load. Insufficient attention has been devoted to the understanding of what mechanisms control channel convergence and meandering, though some similarities and differences between tidal and fluvial channels have emerged from some recent works. In particular, free bars form in tidal channels due to an instability mechanism essentially similar to that occurring under steady conditions though the oscillatory character of the flow field makes the bar pattern non migrating (Seminara and Tubino, 2001). Similarly, forced bars in curved tidal channels are driven by the development of

  15. EXAMINING THE MOVEMENTS OF MOBILE NODES IN THE REAL WORLD TO PRODUCE ACCURATE MOBILITY MODELS

    Directory of Open Access Journals (Sweden)

    TANWEER ALAM

    2010-09-01

    Full Text Available All communication occurs through a wireless median in an ad hoc network. Ad hoc networks are dynamically created and maintained by the individual nodes comprising the network. Random Waypoint Mobility Model is a model that includes pause times between changes in destination and speed. To produce a real-world environment within which an ad hoc network can be formed among a set of nodes, there is a need for the development of realistic, generic and comprehensive mobility models. In this paper, we examine the movements of entities in the real world and present the production of mobility model in an ad hoc network.

  16. Efficient use of available network in mobile for executing mobile application with real time constraints.

    Directory of Open Access Journals (Sweden)

    A.D.Saraf

    2013-06-01

    Full Text Available In today’s world mobile fulfill most of computational needs of average persons in form of different applications. As smart phones works in multiprocessing mode, no of applications gets executedsimultaneously executed in mobile device. Though mobile configurations are improving in (battery, processing speed it still needs additional computing speed to run apps with real time constraints. Thus to fulfill computational needs of real time mobile applications such as augmented reality , some part of execution can be shared with cloud having no of cloud service provider such as Amazon Cloud, Windows Azure. Mobiles can also use machines and other mobile devices such as laptops, smart phones with higher configurations of ram and processor, tablets etc for transferring execution load of applications running on mobile using different wireless connections such as wifi network or blue tooth network. Mobile must able to utilize all available networks in an efficient way to provide best solution in running augmented reality application. In this paper we are providing modified design of Adhoc networks for providing better computation efficiency as well as terms of services in augmented reality application.

  17. Playful Mobility Choices: Motivating informed mobility decision making by applying game mechanics

    OpenAIRE

    2014-01-01

    Motivating people to change their mobility behaviour patterns towards more sustainable forms of mobility is one of the major challenges regarding climate change and quality of life. Recently, an increasing amount of attempts to use gamification for triggering such behavioural changes can be observed. However, little is known about the actual impact of using game elements. This contribution describes a concept for systematically analysing the group-specific effects of different game mechanics ...

  18. Introduction: New Forms of Voter Mobilization in Southeast Asia

    Directory of Open Access Journals (Sweden)

    Eva-Lotta E. Hedman

    2010-01-01

    Full Text Available Southeast Asia in the twenty-first century is no longer what it used to be, at least not at its ASEAN core. By the 1990s, competitive elections had (reemerged as the primary mechanism for the assumption of state office in the Philippines and Thailand. By the turn of the century, Indonesia had experienced two orderly transfers of presidential power, as well as the country’s freest and fairest elections since 1955. Meanwhile, opposition parties made strong showings in federal elections in Malaysia, seizing control over state assemblies and increasing their share of seats in the national legislature.

  19. Results form RESUME 95. Measurements with mobile equipment

    Energy Technology Data Exchange (ETDEWEB)

    Lidstroem, K.; Ulvsand, T.; Aagren, G. [National Defence Research Establisment, Div. of Ionising Radiation and Fallout, Umeaa (Sweden)

    1997-12-31

    This paper presents the results obtained during the NKS, (EKO-3), Exercise Resume-95 by a group from the Division of Ionising Radiation and Fallout, FOA, Umeaa, Sweden. Field gamma measurements were performed in two areas with a HPGe-detector (p-type, 50% relative efficiency) mounted vertically 1 m above the ground or horizontally in a car. One of the areas was an airfield, Vesivehmaa, where 19 measurements were done. The calculated Cs-137 activity was 52.1 {+-} 4.5 kBq/m{sup 2} assuming a two slice distribution model with a homogenous density and activity distribution in each slice. The report contains also the results from a task which included the finding, classification and estimation of the activity of hidden sources within two 10{sup *} 10 m-areas. (au).

  20. Evaluating the mobility potential of antibiotic resistance genes in environmental resistomes without metagenomics

    Science.gov (United States)

    Pärnänen, Katariina; Karkman, Antti; Tamminen, Manu; Lyra, Christina; Hultman, Jenni; Paulin, Lars; Virta, Marko

    2016-01-01

    Antibiotic resistance genes are ubiquitous in the environment. However, only a fraction of them are mobile and able to spread to pathogenic bacteria. Until now, studying the mobility of antibiotic resistance genes in environmental resistomes has been challenging due to inadequate sensitivity and difficulties in contig assembly of metagenome based methods. We developed a new cost and labor efficient method based on Inverse PCR and long read sequencing for studying mobility potential of environmental resistance genes. We applied Inverse PCR on sediment samples and identified 79 different MGE clusters associated with the studied resistance genes, including novel mobile genetic elements, co-selected resistance genes and a new putative antibiotic resistance gene. The results show that the method can be used in antibiotic resistance early warning systems. In comparison to metagenomics, Inverse PCR was markedly more sensitive and provided more data on resistance gene mobility and co-selected resistances. PMID:27767072

  1. Mobile Apps for Librarians

    Science.gov (United States)

    Power, June L.

    2013-01-01

    In an increasing mobile environment, library and reading-related activities often take place on a phone or tablet device. Not only does this mean that library Web sites must keep mobile navigability in mind, but also develop and utilize apps that allow patrons to interact with information and with libraries. While apps do not serve every purpose,…

  2. Innovazione nel mobile learning

    Directory of Open Access Journals (Sweden)

    Immaculada Arnedillo-Sànchez

    2008-01-01

    Full Text Available Descrizione, da una prospettiva europea, dell’innovazione nel settore del mobile learning e l’utilizzabilita’ del mobile learning in contesti educativi. Vengono illustrate i principali progetti europei di m-learning e si esamina le prospettive pedagogiche e teoriche relative al campo.

  3. Mobility Test Article (MTA)

    Science.gov (United States)

    1965-01-01

    A concept of a possible Lunar Roving Vehicle (LRV) built for NASA's Marshall Space Flight Center (MSFC). This Mobility Test Article (MTA) is one of many that provided data contributing to the design of the LRV, developed under the direction of MSFC. The LRV was designed to allow Apollo astronauts a greater range of mobility during lunar exploration missions.

  4. Mobilities, Futures & the City

    DEFF Research Database (Denmark)

    Freudendal-Pedersen, Malene; Kesselring, Sven

    2016-01-01

    The future of cities and regions will be strongly shaped by the mobilities of people, goods, modes of transport, waste and information. In many ways, the ‘why and ‘for what’ often get lost in discourses on planning and designing mobilities. The predominant planning paradigm still conceptualizes...

  5. Mobile Goes Mainstream

    Science.gov (United States)

    Eisele-Dyrli, Kurt

    2011-01-01

    Mobile learning--the use of mobile devices for educational purposes by students--is rapidly moving from an experimental initiative by a few innovative districts over the last five years to a broadly accepted concept in K12. The latest research and surveys, results of pilot programs, and analysis of trends in both public education and the broader…

  6. Designing for mobile interaction

    DEFF Research Database (Denmark)

    Nazzi, Elena

    2009-01-01

    The theme of this PhD project is designing for mobile interaction with devices and services, for the accessing, making, and sharing of information, taking into account the dynamic physical and social settings that embrace this interaction. To narrow down this theme, the whole project focuses...... on the exploitation of social interaction --- in particular among senior citizens --- to enhance and support mobile interaction....

  7. Mobile Informal Learning

    NARCIS (Netherlands)

    Börner, Dirk; Glahn, Christian; Specht, Marcus

    2009-01-01

    Börner, D., Glahn, C., & Specht, M. (2009). Mobile Informal Learning. Presentation for the Education in the Wild: contextual and location-based mobile learning in action workshop at the STELLAR Alpine Rendez-Vous 2009. November, 30-December, 3, 2009, Garmisch-Partenkirchen, Germany.

  8. Mobile Learning Anytime, Anywhere

    Science.gov (United States)

    Hlodan, Oksana

    2010-01-01

    Some educational institutions are taking the leap to mobile learning (m-learning) by giving out free iPods. For example, Abilene Christian University gave iPods or iPhones to freshman students and developed 15 Web applications specifically for the mobile devices. The iPod is not the only ubiquitous m-learning device. Any technology that connects…

  9. Micro Mobility Marketing

    DEFF Research Database (Denmark)

    Hosbond, Jens Henrik; Skov, Mikael B.

    2008-01-01

    and differences between micro mobility marketing and the traditional mobile marketing in the large. Finally, we suggest areas for further study.Journal of Targeting, Measurement and Analysis for Marketing (2007) 16, 68-77. doi:10.1057/palgrave.jt.5750058; published online 24 December 2007...

  10. Mobile Informal Learning

    NARCIS (Netherlands)

    Börner, Dirk; Glahn, Christian; Specht, Marcus

    2009-01-01

    Börner, D., Glahn, C., & Specht, M. (2009). Mobile Informal Learning. Presentation for the Education in the Wild: contextual and location-based mobile learning in action workshop at the STELLAR Alpine Rendez-Vous 2009. November, 30-December, 3, 2009, Garmisch-Partenkirchen, Germany.

  11. Mobile-first Bootstrap

    CERN Document Server

    Magno, Alexandre

    2013-01-01

    A practical, step-by-step tutorial on developing websites for mobile using Bootstrap.This book is for anyone who wants to get acquainted with the new features available in Bootstrap 3 and who wants to develop websites with the mobile-first feature of Bootstrap. The reader should have a basic knowledge of Bootstrap as a frontend framework.

  12. Mastering Mobile Security

    Science.gov (United States)

    Panettieri, Joseph C.

    2007-01-01

    Without proper security, mobile devices are easy targets for worms, viruses, and so-called robot ("bot") networks. Hackers increasingly use bot networks to launch massive attacks against eCommerce websites--potentially targeting one's online tuition payment or fundraising/financial development systems. How can one defend his mobile systems against…

  13. Mobile communication security

    NARCIS (Netherlands)

    Broek, F.M.J. van den

    2016-01-01

    Security of the mobile network Fabian van den Broek We looked at the security of the wireless connection between mobile phone and cell towers and suggested possible improvements. The security was analysed on a design level, by looking at the protocols and encryption techniques, but also on an impl

  14. Mastering Mobile Security

    Science.gov (United States)

    Panettieri, Joseph C.

    2007-01-01

    Without proper security, mobile devices are easy targets for worms, viruses, and so-called robot ("bot") networks. Hackers increasingly use bot networks to launch massive attacks against eCommerce websites--potentially targeting one's online tuition payment or fundraising/financial development systems. How can one defend his mobile systems against…

  15. Mobile communication security

    NARCIS (Netherlands)

    Broek, F.M.J. van den

    2016-01-01

    Security of the mobile network Fabian van den Broek We looked at the security of the wireless connection between mobile phone and cell towers and suggested possible improvements. The security was analysed on a design level, by looking at the protocols and encryption techniques, but also on an impl

  16. Children, Mobility, and Space

    DEFF Research Database (Denmark)

    Christensen, Pia; Romero Mikkelsen, Miguel; Nielsen, Thomas Alexander Sick

    2011-01-01

    This article discusses the potentials of a mixed methods approach to the study of children’s mobility patterns. The methodology presented here combined ethnographic fieldwork with global positioning system technology and an interactive questionnaire that children completed via mobile phone. This ...

  17. Security for Mobility

    DEFF Research Database (Denmark)

    Nielson, Hanne Riis; Nielson, Flemming; Buchholtz, Mikael

    2004-01-01

    We show how to use static analysis to provide information about security issues related to mobility. First the syntax and semantics of Mobile Ambients is reviewed and we show how to obtain a so-called 0CFA analysis that can be implemented in polynomial time. Next we consider discretionary access...

  18. Mobile Apps for Librarians

    Science.gov (United States)

    Power, June L.

    2013-01-01

    In an increasing mobile environment, library and reading-related activities often take place on a phone or tablet device. Not only does this mean that library Web sites must keep mobile navigability in mind, but also develop and utilize apps that allow patrons to interact with information and with libraries. While apps do not serve every purpose,…

  19. Security for Mobility

    DEFF Research Database (Denmark)

    Nielson, Hanne Riis; Nielson, Flemming; Buchholtz, Mikael

    2004-01-01

    We show how to use static analysis to provide information about security issues related to mobility. First the syntax and semantics of Mobile Ambients is reviewed and we show how to obtain a so-called 0CFA analysis that can be implemented in polynomial time. Next we consider discretionary access...

  20. Security for Mobility

    DEFF Research Database (Denmark)

    Nielson, Hanne Riis; Nielson, Flemming; Buchholtz, Mikael

    2002-01-01

    We show how to use static analysis to provide information about security issues related to mobility. First the syntax and semantics of Mobile Ambients is reviewed and we show how to obtain a so-called 0CFA analysis that can be implemented in polynomial time. Next we consider discretionary access...

  1. Increasing mobile radiography productivity.

    Science.gov (United States)

    Wong, Edward; Lung, Ngan Tsz; Ng, Kris; Jeor, Patrick

    2013-01-01

    Mobile radiography using computed radiography (CR) cassettes is a common equipment combination with a workflow bottleneck limited by location of CR readers. Advent of direct digital radiography (DDR) mobile x-ray machines removes this limitation by immediate image review and quality control. Through the use of key performance indicators (KPIs), the increase in efficiency can be quantified.

  2. Mobility Test Article (MTA)

    Science.gov (United States)

    1965-01-01

    A concept of a possible Lunar Roving Vehicle (LRV) built for NASA's Marshall Space Flight Center (MSFC). This Mobility Test Article (MTA) is one of many that provided data contributing to the design of the LRV, developed under the direction of MSFC. The LRV was designed to allow Apollo astronauts a greater range of mobility during lunar exploration missions.

  3. Learning to Be Mobile

    DEFF Research Database (Denmark)

    McIlvenny, Paul

    As an antidote to the fixation with automobility, cycling and other such highly mobile ‘carbon neutral’ leisure activities are the focus of recent studies that use mobile ‘travelling with’ methods such as the ‘ride along’ or headcam POV video technology with post-ride debriefing. Much...

  4. Wireless mobile Internet security

    CERN Document Server

    Rhee, Man Young

    2013-01-01

      The mobile industry for wireless cellular services has grown at a rapid pace over the past decade. Similarly, Internet service technology has also made dramatic growth through the World Wide Web with a wire line infrastructure. Realization for complete wired/wireless mobile Internet technologies will become the future objectives for convergence of these technologies thr

  5. Mobile medical visual information retrieval.

    Science.gov (United States)

    Depeursinge, Adrien; Duc, Samuel; Eggel, Ivan; Müller, Henning

    2012-01-01

    In this paper, we propose mobile access to peer-reviewed medical information based on textual search and content-based visual image retrieval. Web-based interfaces designed for limited screen space were developed to query via web services a medical information retrieval engine optimizing the amount of data to be transferred in wireless form. Visual and textual retrieval engines with state-of-the-art performance were integrated. Results obtained show a good usability of the software. Future use in clinical environments has the potential of increasing quality of patient care through bedside access to the medical literature in context.

  6. Smartphones Based Mobile Mapping Systems

    Science.gov (United States)

    Al-Hamad, A.; El-Sheimy, N.

    2014-06-01

    The past 20 years have witnessed an explosive growth in the demand for geo-spatial data. This demand has numerous sources and takes many forms; however, the net effect is an ever-increasing thirst for data that is more accurate, has higher density, is produced more rapidly, and is acquired less expensively. For mapping and Geographic Information Systems (GIS) projects, this has been achieved through the major development of Mobile Mapping Systems (MMS). MMS integrate various navigation and remote sensing technologies which allow mapping from moving platforms (e.g. cars, airplanes, boats, etc.) to obtain the 3D coordinates of the points of interest. Such systems obtain accuracies that are suitable for all but the most demanding mapping and engineering applications. However, this accuracy doesn't come cheaply. As a consequence of the platform and navigation and mapping technologies used, even an "inexpensive" system costs well over 200 000 USD. Today's mobile phones are getting ever more sophisticated. Phone makers are determined to reduce the gap between computers and mobile phones. Smartphones, in addition to becoming status symbols, are increasingly being equipped with extended Global Positioning System (GPS) capabilities, Micro Electro Mechanical System (MEMS) inertial sensors, extremely powerful computing power and very high resolution cameras. Using all of these components, smartphones have the potential to replace the traditional land MMS and portable GPS/GIS equipment. This paper introduces an innovative application of smartphones as a very low cost portable MMS for mapping and GIS applications.

  7. mSpace Mobile: Exploring Support for Mobile Tasks

    OpenAIRE

    Wilson, Max L.; Russell, Alistair; Smith, Daniel A.; Schraefel, M. C.

    2006-01-01

    In the following paper we present a formative study comparing two Web application interfaces, mSpace Mobile and Google Local in supporting Web-based location discovery tasks on mobile devices while stationary and while on the move. While mSpace Mobile performed well in both stationary and mobile conditions, performance in Google Local dropped significantly in the mobile condition. We postulate that mSpace Mobile performed better because it breaks the paradigm of the page for delivering Web co...

  8. MOBILIZING KNOWLEDGE IN DENMARK

    DEFF Research Database (Denmark)

    Holm, Claus

    2011-01-01

    competition state – that is to be realized by fulfilling the ambitions for comprehensive knowledge mobilization through education.1 On the other hand, Denmark is having a hard time finding a broad consensus when what is, in principle, supposed to be a common political will is to be translated into knowledge......Knowledge mobilization is not only a new expression in a Danish context. It is also an interesting concept to introduce and discuss. For doesn’t knowledge mobilization have more – or, at least, as much – to do with politics as with education research or education in itself? Doesn’t modern knowledge...... mobilization have to do with a new political will to mobilize the population by creating a connection between education research and education? On the basis of this report on the Danish efforts with respect to ’knowledge mobilization’, these questions can be answered affirmatively; the extent of knowledge...

  9. Intergenerational earnings mobilities

    DEFF Research Database (Denmark)

    Hussain, Azhar; Munk, Martin D.; Bonke, Jens

    2009-01-01

    This article gives various estimates of intergenerational earnings mobility by applying different earning periods, age brackets, and earning components. The methodology enables us to investigate how sensitive results are to different delimitations and, thereby, to make more accurate international...... comparisons of intergenerational earnings mobility. We find that intergenerational earnings mobility is found to be substantially lower when hourly wage rates rather than annual earnings are used, whether the latter are inclusive or exclusive of public transfers. Moreover, when the same specifications...... are applied for Denmark as for other countries, we find that intergenerational earnings mobility from father to son in Denmark is on the same level as in Sweden, Norway, and Finland, whereas the intergenerational earnings mobility in all the Nordic countries is found to be higher than in the United Kingdom...

  10. Making Daily Mobility

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Wind, Simon

    ’s normative and affective orientation towards daily mobility, spanning from being a ‘waste of time’ to being a ‘meaningful’ activity. For instance, besides fulfilling a practical purpose, mobility practices are often ‘mobile-with’ constellations of synchronised, however temporal, movement and thus household......In 2012 the average daily transportation distance for every Dane were 40 km (TU Data). Realising how much of life is spend thinking about, planning and performing mobility practices it becomes evident that it is much more than an instrumental physical phenomenon – it has great repercussions on life......, social networks, understanding of places and ultimately ourselves and others. To successfully accomplish everyday life, households have to cope with large number of different activities and mobility in relation to their children, work, social life, obligations, expectations, needs and wishes. Drawing...

  11. Contextualizing mobile IT

    DEFF Research Database (Denmark)

    Messeter, Jörn; Brandt, Eva; Halse, Joachim

    2004-01-01

    Information and communication technologies are moving into the era of ubiquitous computing, with increased density of technology and increased mobility and continuity in use. From a design perspective, addressing the accommodation and coordination of multiple devices and services in situated use...... across different contexts is becoming increasingly important. In the COMIT project, ethnographic fieldwork has been combined with participatory design engaging users, designers and researchers in order to explore mobile IT use as well as the design of mobile IT concepts. Four seclected scenarios from...... the project are presented and discussed regarding implications for the design of mobile IT devices, with particular focus on (1) coping with multiple social contexts, and (2) the configuration and connectivity of mobile devices...

  12. Mobile Collocated Interactions

    DEFF Research Database (Denmark)

    Lucero, Andrés; Clawson, James; Lyons, Kent

    2015-01-01

    Mobile devices such as smartphones and tablets were originally conceived and have traditionally been utilized for individual use. Research on mobile collocated interactions has been looking at situations in which collocated users engage in collaborative activities using their mobile devices, thus...... going from personal/individual toward shared/multiuser experiences and interactions. However, computers are getting smaller, more powerful, and closer to our bodies. Therefore, mobile collocated interactions research, which originally looked at smartphones and tablets, will inevitably include ever......-smaller computers, ones that can be worn on our wrists or other parts of the body. The focus of this workshop is to bring together a community of researchers, designers and practitioners to explore the potential of extending mobile collocated interactions to the use of wearable devices....

  13. The aerosols' fate in a putative ammonia ocean on Titan

    Science.gov (United States)

    Ramírez, S. I.; Coll, P.; Buch, A.; Brassé, C.; Poch, O.; Raulin, F.

    2010-04-01

    A laboratory study on the chemical transformation of Titan's aerosol analogues placed under putative surface conditions of the satellite was performed. The surface of Titan was one of the targets of the Cassini-Huygens mission and of several of the Cassini orbiter instruments, especially ISS, VIMS and Radar. The first images revealed an interesting solid surface with features that suggest aeolian, tectonic, fluvial processes and even an impact structure[1]. Since then, more detailed descriptions of dunes, channels, lakes, impact craters and cryovolcanic structures have been documented[2]. The existence of an internal liquid water ocean, containing a few percent ammonia has been proposed[2, 3]. It has also been proposed that ammonia-water mixtures can erupt from the putative subsurface ocean leading to cryovolcanism[4]. The Cassini Titan Radar Mapper obtained Synthetic Aperture Radar (SAR) images during 2004 and 2005 that revealed a highly complex geology occurring at Titan's surface[5], among which cryovolcanic features play a central role. The composition of the cryomagma is mainly proposed to be a mixture of water ice and ammonia[6, 7, 8], although ammonia has not been directly detected on Titan, but suggested by recent Cassini-VIMS observations[9]. In order to understand the role that ammonia may play on the chemical transformation of atmospheric aerosols once they reach the surface, we designed the following protocol: laboratory analogues of Titan's aerosols were synthesized from a N2:CH4 (98:2) mixture irradiated under a continuous flow regime of 845 sccm inside which, a cold plasma of 180 W was established. The synthesized analogues were recovered and partitioned in several 10.0 mg samples that were placed in 4.0 mL-volume of aqueous ammonia solutions (25.00, 12.50, 6.25 and 3.125%) at different temperatures (298, 277, 253 and 93 K) for 10 weeks. After a derivatization process performed to the aerosols' refractory phase with N

  14. Gone Mobile? (Mobile Libraries Survey 2010)

    Science.gov (United States)

    Thomas, Lisa Carlucci

    2010-01-01

    Librarians, like patrons and researchers, are caught between traditional library service models and the promise of evolving information technologies. In recent years, professional conferences have strategically featured programs and presentations geared toward building a mobile agenda and adapting or adopting services to meet new demands of mobile…

  15. Tissue factor residues that putatively interact with membrane phospholipids.

    Directory of Open Access Journals (Sweden)

    Ke Ke

    Full Text Available Blood clotting is initiated by the two-subunit enzyme consisting of the plasma protease, factor VIIa (the catalytic subunit, bound to the integral membrane protein, tissue factor (the regulatory subunit. Molecular dynamics simulations have predicted that certain residues in the tissue factor ectodomain interact with phosphatidylserine headgroups to ensure optimal positioning of the tissue factor/factor VIIa complex relative to its membrane-bound protein substrates, factors IX and X. In this study, we individually mutated to alanine all the putative phosphatidylserine-interactive residues in the tissue factor ectodomain and measured their effects on tissue factor cofactor function (activation of factors IX and X by tissue factor/factor VIIa, and clotting of plasma. Some tissue factor mutants exhibited decreased activity in all three assays, with the most profound defects observed from mutations in or near the flexible loop from Lys159 to Gly164. The decreased activity of all of these tissue factor mutants could be partially or completely overcome by increasing the phosphatidylserine content of tissue factor-liposomes. Additionally, yeast surface display was used to screen a random library of tissue factor mutants for enhanced factor VIIa binding. Surprisingly, mutations at a single amino acid (Lys165 predominated, with the Lys165→Glu mutant exhibiting a 3-fold enhancement in factor VIIa binding affinity. Our studies reveal the functional contributions of residues in the C-terminal half of the tissue factor ectodomain that are implicated in interacting with phosphatidylserine headgroups to enhance tissue factor cofactor activity, possibly by allosterically modulating the conformation of the adjacent substrate-binding exosite region of tissue factor.

  16. A putative viral defence mechanism in archaeal cells

    Directory of Open Access Journals (Sweden)

    Reidun Lillestøl

    2006-01-01

    Full Text Available Clusters of regularly spaced direct repeats, separated by unconserved spacer sequences, are ubiquitous in archaeal chromosomes and occur in some plasmids. Some clusters constitute around 1% of chromosomal DNA. Similarly structured clusters, generally smaller, also occur in some bacterial chromosomes. Although early studies implicated these clusters in segregation/partition functions, recent evidence suggests that the spacer sequences derive from extrachromosomal elements, and, primarily, viruses. This has led to the proposal that the clusters provide a defence against viral propagation in cells, and that both the mode of inhibition of viral propagation and the mechanism of adding spacer-repeat units to clusters, are dependent on RNAs transcribed from the clusters. Moreover, the putative inhibitory apparatus (piRNA-based may be evolutionarily related to the interference RNA systems (siRNA and miRNA, which are common in eukarya. Here, we analyze all the current data on archaeal repeat clusters and provide some new insights into their diverse structures, transcriptional properties and mode of structural development. The results are consistent with larger cluster transcripts being processed at the centers of the repeat sequences and being further trimmed by exonucleases to yield a dominant, intracellular RNA species, which corresponds approximately to the size of a spacer. Furthermore, analysis of the extensive clusters of Sulfolobus solfataricus strains P1 and P2B provides support for the presence of a flanking sequence adjoining a cluster being a prerequisite for the incorporation of new spacer-repeat units, which occurs between the flanking sequence and the cluster. An archaeal database summarizing the data will be maintained at http://dac.molbio.ku.dk/dbs/SRSR/.

  17. Putative Risk Factors in Developmental Dyslexia: A Case-Control Study of Italian Children

    Science.gov (United States)

    Mascheretti, Sara; Marino, Cecilia; Simone, Daniela; Quadrelli, Ermanno; Riva, Valentina; Cellino, Maria Rosaria; Maziade, Michel; Brombin, Chiara; Battaglia, Marco

    2015-01-01

    Although dyslexia runs in families, several putative risk factors that cannot be immediately identified as genetic predict reading disability. Published studies analyzed one or a few risk factors at a time, with relatively inconsistent results. To assess the contribution of several putative risk factors to the development of dyslexia, we conducted…

  18. Putative Risk Factors in Developmental Dyslexia: A Case-Control Study of Italian Children

    Science.gov (United States)

    Mascheretti, Sara; Marino, Cecilia; Simone, Daniela; Quadrelli, Ermanno; Riva, Valentina; Cellino, Maria Rosaria; Maziade, Michel; Brombin, Chiara; Battaglia, Marco

    2015-01-01

    Although dyslexia runs in families, several putative risk factors that cannot be immediately identified as genetic predict reading disability. Published studies analyzed one or a few risk factors at a time, with relatively inconsistent results. To assess the contribution of several putative risk factors to the development of dyslexia, we conducted…

  19. Improving TCP Performance over Mobile Satellite Channels: The ACKPrime Approach

    Science.gov (United States)

    Scott, Keith; Czetty, Stephen

    1998-01-01

    Various issues associated with "Improving TCP Performance over Mobile Satellite Channels: The ACKPrime Approach" are presented in viewgraph form. Specific topics include: 1) TCP over mobile satellite links; 2) ways of breaking the control loop at the groundstation; 3) ACK implementation; and 4) ACK performance.

  20. A Review of Integrating Mobile Phones for Language Learning

    Science.gov (United States)

    Darmi, Ramiza; Albion, Peter

    2014-01-01

    Mobile learning (m-learning) is gradually being introduced in language classrooms. All forms of mobile technology represent portability with smarter features. Studies have proven the concomitant role of technology beneficial for language learning. Various features in the technology have been exploited and researched for acquiring and learning…

  1. Contributors Form

    Directory of Open Access Journals (Sweden)

    Chief Editor

    2016-06-01

    to produce preprints or reprints and translate into languages other than English for sale or free distribution; and 4 the right to republish the work in a collection of articles in any other mechanical or electronic format. We give the rights to the corresponding author to make necessary changes as per the request of the journal, do the rest of the correspondence on our behalf and he/she will act as the guarantor for the manuscript on our behalf. All persons who have made substantial contributions to the work reported in the manuscript, but who are not contributors, are named in the Acknowledgment and have given me/us their written permission to be named. If I/we do not include an Acknowledgment that means I/we have not received substantial contributions from non-contributors and no contributor has been omitted.S NoAuthors' NamesContribution (IJCME Guidelines{1 substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; 2 drafting the article or revising it critically for important intellectual content; and 3 final approval of the version to be published. Authors should meet conditions 1, 2, and 3}.SignatureDate                              Note: All the authors are required to sign independently in this form in the sequence given above. In case an author has left the institution/country and whose whereabouts are not known, the senior author may sign on his/her behalf taking the responsibility.No addition/deletion/ or any change in the sequence of the authorship will be permissible at a later stage, without valid reasons and permission of the Editor.If the authorship is contested at any stage, the article will be either returned or will not be processed for publication till the issue is solved.Maximum up to 4 authors for short communication and up to 6 authors for original article.

  2. HUMAN INTERACTION WITH MOBILE APPLICATIONS

    OpenAIRE

    Alin Zamfiroiu; Emanuel Herteliu; Bogdan Vintila

    2012-01-01

    Computing - human interaction is a very important paradigm because informatics applications are created to be used by people via human interaction. Nowadays mobile applications are more used so is necessarily to talk about mobile - human interaction. In this paper types of mobile devices are presented. Citizen oriented character of mobile application and his utility are described. Different means of interactions with mobile devices are analyzed and in the end of the paper direction of mobile ...

  3. Controlling mobile robot via bluetooth

    OpenAIRE

    Cekova, Katerina; Gelev, Saso

    2016-01-01

    This paper describes hardware architecture of mobile robot, design and implementation of Android and Windows applications. It is use Bluetooth communication between mobile phone and mobile robot. The mobile robot is control by applications. Applications send message to the mobile robot to turn left, right or move forward or backward and to stop. The mobile robot is composed of Bluetooth module, Arduino Uno, H-Bridge, two DC motors, jumper wires and Breadboard.

  4. Exploration of mobile educational technology

    OpenAIRE

    Hosny, W.

    2007-01-01

    Recent advances in mobile and wireless technology could be utilised to enhance the delivery of educational programmes. The use of this technology is known as “Mobile Education”. Mobile education technology provides unique opportunities for educators to flexibly deliver their educational material to learners via mobile services anywhere at any time. Moreover, the material delivered could be adapted to the learners’ needs and preferences. Examples of mobile devices which could be used in mobile...

  5. Mobile Phones and Politics in China

    DEFF Research Database (Denmark)

    Liu, Jun

    2013-01-01

    The penetration of mobile phones in Chinese daily life has made collective actions easier to organize and challenged government censorship. Highlighting this new form of communication, the following essay shows how the traditional mass media’s role as gatekeeper is waning....

  6. DMC - Distributed and mobile collaboration workshop report

    NARCIS (Netherlands)

    Aiello, Marco; Dustdar, Schahram; Gall, Harald; Reddy, SM

    2007-01-01

    The latest trends in distributed and mobile collaboration technologies allow people to move across team forms and organizational boundaries as well as to collaborate among/in organizations and communities. The ability to query the company's distributed knowledge base and to cooperate with co-workers

  7. DMC - Distributed and mobile collaboration workshop report

    NARCIS (Netherlands)

    Aiello, Marco; Dustdar, Schahram; Gall, Harald; Reddy, SM

    2007-01-01

    The latest trends in distributed and mobile collaboration technologies allow people to move across team forms and organizational boundaries as well as to collaborate among/in organizations and communities. The ability to query the company's distributed knowledge base and to cooperate with co-workers

  8. Client Mobile Software Design Principles for Mobile Learning Systems

    Directory of Open Access Journals (Sweden)

    Qing Tan

    2009-01-01

    Full Text Available In a client-server mobile learning system, client mobile software must run on the mobile phone to acquire, package, and send student’s interaction data via the mobile communications network to the connected mobile application server. The server will receive and process the client data in order to offer appropriate content and learning activities. To develop the mobile learning systems there are a number of very important issues that must be addressed. Mobile phones have scarce computing resources. They consist of heterogeneous devices and use various mobile operating systems, they have limitations with their user/device interaction capabilities, high data communications cost, and must provide for device mobility and portability. In this paper we propose five principles for designing Client mobile learning software. A location-based adaptive mobile learning system is presented as a proof of concept to demonstrate the applicability of these design principles.

  9. Mobile and contextual learning

    Directory of Open Access Journals (Sweden)

    Agnes Kukulska-Hulme

    2009-12-01

    Full Text Available Is mobile learning just a part of everyday learning? This is a relevant question in an age when most people throughout the world now have access to mobile phones and mobility is increasingly taken for granted. In one sense, mobile learning is no different to carrying a textbook or learning through conversations at home, as part of formal education or in the workplace. The technology may be more engaging, but is the learning any different? Despite the ubiquity of mobile phones, smartphones, mp3 players and, increasingly, access to Wi-Fi connections and GPS navigation, the reasons for using mobile and wireless technologies in education are not yet widely known. There is significant specialist expertise, built from ten years of research (and more recently, reflective practice to demonstrate the unique characteristics of mobile learning, which include orchestrating shared learning with personal devices across formal and informal settings, providing immediately useful information, offering timely revision and reflection, connecting real and virtual locations, and enriching field trips and cultural visits. This knowledge needs to be disseminated and examined from new perspectives.

  10. Mobile Sensing Systems

    Directory of Open Access Journals (Sweden)

    Elsa Macias

    2013-12-01

    Full Text Available Rich-sensor smart phones have made possible the recent birth of the mobile sensing research area as part of ubiquitous sensing which integrates other areas such as wireless sensor networks and web sensing. There are several types of mobile sensing: individual, participatory, opportunistic, crowd, social, etc. The object of sensing can be people-centered or environment-centered. The sensing domain can be home, urban, vehicular… Currently there are barriers that limit the social acceptance of mobile sensing systems. Examples of social barriers are privacy concerns, restrictive laws in some countries and the absence of economic incentives that might encourage people to participate in a sensing campaign. Several technical barriers are phone energy savings and the variety of sensors and software for their management. Some existing surveys partially tackle the topic of mobile sensing systems. Published papers theoretically or partially solve the above barriers. We complete the above surveys with new works, review the barriers of mobile sensing systems and propose some ideas for efficiently implementing sensing, fusion, learning, security, privacy and energy saving for any type of mobile sensing system, and propose several realistic research challenges. The main objective is to reduce the learning curve in mobile sensing systems where the complexity is very high.

  11. Mobile Sensing Systems

    Science.gov (United States)

    Macias, Elsa; Suarez, Alvaro; Lloret, Jaime

    2013-01-01

    Rich-sensor smart phones have made possible the recent birth of the mobile sensing research area as part of ubiquitous sensing which integrates other areas such as wireless sensor networks and web sensing. There are several types of mobile sensing: individual, participatory, opportunistic, crowd, social, etc. The object of sensing can be people-centered or environment-centered. The sensing domain can be home, urban, vehicular… Currently there are barriers that limit the social acceptance of mobile sensing systems. Examples of social barriers are privacy concerns, restrictive laws in some countries and the absence of economic incentives that might encourage people to participate in a sensing campaign. Several technical barriers are phone energy savings and the variety of sensors and software for their management. Some existing surveys partially tackle the topic of mobile sensing systems. Published papers theoretically or partially solve the above barriers. We complete the above surveys with new works, review the barriers of mobile sensing systems and propose some ideas for efficiently implementing sensing, fusion, learning, security, privacy and energy saving for any type of mobile sensing system, and propose several realistic research challenges. The main objective is to reduce the learning curve in mobile sensing systems where the complexity is very high. PMID:24351637

  12. Cooperative Mobile Web Browsing

    Directory of Open Access Journals (Sweden)

    Zhang Q

    2009-01-01

    Full Text Available This paper advocates a novel approach for mobile web browsing based on cooperation among wireless devices within close proximity operating in a cellular environment. In the actual state of the art, mobile phones can access the web using different cellular technologies. However, the supported data rates are not sufficient to cope with the ever increasing traffic requirements resulting from advanced and rich content services. Extending the state of the art, higher data rates can only be achieved by increasing complexity, cost, and energy consumption of mobile phones. In contrast to the linear extension of current technology, we propose a novel architecture where mobile phones are grouped together in clusters, using a short-range communication such as Bluetooth, sharing, and accumulating their cellular capacity. The accumulated data rate resulting from collaborative interactions over short-range links can then be used for cooperative mobile web browsing. By implementing the cooperative web browsing on commercial mobile phones, it will be shown that better performance is achieved in terms of increased data rate and therefore reduced access times, resulting in a significantly enhanced web browsing user experience on mobile phones.

  13. Editorial: Mobile (March 2010

    Directory of Open Access Journals (Sweden)

    Thomas Kunz

    2010-02-01

    Full Text Available Open source software and hardware has become an accepted way of developing new and interesting applications in many information and communication technology domains: operating systems, databases, Web infrastructure, and applications. It's not surprising that with the increasing popularity of mobile handheld devices, users and researchers have explored the power of open approaches to providing innovative new applications and services in this domain. However, unlike personal computers and the Internet, mobile handsets were tightly controlled by mobile network operators (MNOs who developed a vertical ecosystem by integrating the communication infrastructure, the handheld device hardware, and often the applications installed on those devices. The software and protocols running the mobile communications infrastructure and devices are often standardized by membership-only bodies, where large MNOs and manufacturers have a predominant influence. These players invest significant financial resources into shaping the industry along their vision to gain a competitive advantage. A current example is the ongoing battle about the dominant radio access technology for 4G cellular systems: LTE vs. Wimax. These trends have changed recently. Companies such as Google, Nokia, or Openmoko and Industry Alliances such as the Open Handset Alliance are providing the core building blocks, both in hardware as well as software, of increasingly open mobile devices. This issue of the OSBR reviews the relevant trends in the open mobile platform space from a number of perspectives. As the articles in these issue show, there is a lot of exciting ongoing work that brings the power of open source development to the mobile space. This trend is not just confined to the mobile devices as there are also efforts in the development of open mobile infrastructure elements and whole systems.

  14. Putative DNA G-quadruplex formation within the promoters of Plasmodium falciparum var genes

    Directory of Open Access Journals (Sweden)

    Rowe J

    2009-08-01

    Full Text Available Abstract Background Guanine-rich nucleic acid sequences are capable of folding into an intramolecular four-stranded structure called a G-quadruplex. When found in gene promoter regions, G-quadruplexes can downregulate gene expression, possibly by blocking the transcriptional machinery. Here we have used a genome-wide bioinformatic approach to identify Putative G-Quadruplex Sequences (PQS in the Plasmodium falciparum genome, along with biophysical techniques to examine the physiological stability of P. falciparum PQS in vitro. Results We identified 63 PQS in the non-telomeric regions of the P. falciparum clone 3D7. Interestingly, 16 of these PQS occurred in the upstream region of a subset of the P. falciparum var genes (group B var genes. The var gene family encodes PfEMP1, the parasite's major variant antigen and adhesin expressed at the surface of infected erythrocytes, that plays a key role in malaria pathogenesis and immune evasion. The ability of the PQS found in the upstream regions of group B var genes (UpsB-Q to form stable G-quadruplex structures in vitro was confirmed using 1H NMR, circular dichroism, UV spectroscopy, and thermal denaturation experiments. Moreover, the synthetic compound BOQ1 that shows a higher affinity for DNA forming quadruplex rather than duplex structures was found to bind with high affinity to the UpsB-Q. Conclusion This is the first demonstration of non-telomeric PQS in the genome of P. falciparum that form stable G-quadruplexes under physiological conditions in vitro. These results allow the generation of a novel hypothesis that the G-quadruplex sequences in the upstream regions of var genes have the potential to play a role in the transcriptional control of this major virulence-associated multi-gene family.

  15. OS Independent Mobile Solutions for Manufacturing Execution Systems

    Directory of Open Access Journals (Sweden)

    Heiko Meyer

    2013-12-01

    Full Text Available From the suppliers' perspective it is best to provide the user of a plant with a mobile solution in the form of perfectly matching Apps for the rolled-out manufacturing execution system. Due to the extremely short innovation cycle in the mobile phone development and not least because of the first iPhone generation launch in 2007 the mobile phone market completely changed over the past four years. Today, a large percentage of the sold devices can be classified as smart phones. The paper describes an easy and reliable way to develop OS independent mobile solutions for all common smartphones based on standard technologies.

  16. ANALYSE OF LABOR FORCE MOBILITY PHENOMENOM ON ROMANIAN INTERNAL MARKET

    Directory of Open Access Journals (Sweden)

    LUCIAN-ION MEDAR

    2012-01-01

    Full Text Available Labor force mobility is an increasingly important component of contemporary society and equally adjustment tool imbalances in labor markets. The phenomenon of labor mobility is nowadays the most dynamic form of movement of potentially active population. Using cluster analysis this paper aims to highlight the relationship between economic and regional development of counties and the phenomenon of internal labor mobility. Labor mobility is both an explanatory factor of economic development and its effect or result, based on the natural desire of individuals to increase income and improve quality of life by changing jobs, which could contribute to GDP growth and economic growth.

  17. Within- and cross-firm mobility and earnings growth

    DEFF Research Database (Denmark)

    Frederiksen, Anders; Halliday, Timothy; Koch, Alexander Karl

    While it is well established that both promotions within firms and mobility across firms lead to substantial earnings progression, few studies offer an integrated analysis of the effects of these two types of mobility on earnings growth. To do this, we exploit a large Danish panel data set......, and not horizontal mobility across firms is what ultimately matters for gross earnings growth. However, because of progressive taxation, we do not see any effects of vertical mobility on net earnings growth. Instead, the fruits of promotions are enjoyed in the form of tax shields such as future consumption via tax...

  18. Mobile Game Probes

    DEFF Research Database (Denmark)

    Borup Lynggaard, Aviaja

    2006-01-01

    This paper will examine how probes can be useful for game designers in the preliminary phases of a design process. The work is based upon a case study concerning pervasive mobile phone games where Mobile Game Probes have emerged from the project. The new probes are aimed towards a specific target...... group and the goal is to specify the probes so they will cover the most relevant areas for our project. The Mobile Game Probes generated many interesting results and new issues occurred, since the probes came to be dynamic and favorable for the process in new ways....

  19. Mobility Management in Denmark

    DEFF Research Database (Denmark)

    Guasco, Clement Nicolas

    2012-01-01

    There is today an undisputed superiority of cars on any other means of transportation, both practically and psychologically. However, the reliance on cars as the main means of transportation has led to a number of social and environmental problems. Mobility Management aims at managing the way...... people fulfil their mobility needs so that they rely less on their cars and start using alternatives such as bicycles and public transport. This article analyses the possibility to use businesses as vectors for introducing Mobility Management within social practices in Denmark in the light of the recent...

  20. Mobile sociology. 2000.

    Science.gov (United States)

    Urry, John

    2010-01-01

    This article seeks to develop a manifesto for a sociology concerned with the diverse mobilities of peoples, objects, images, information, and wastes; and of the complex interdependencies between, and social consequences of, such diverse mobilities. A number of key concepts relevant for such a sociology are elaborated: 'gamekeeping', networks, fluids, scapes, flows, complexity and iteration. The article concludes by suggesting that a 'global civil society' might constitute the social base of a sociology of mobilities as we move into the twenty-first century.

  1. Mobile energy sharing futures

    DEFF Research Database (Denmark)

    Worgan, Paul; Knibbe, Jarrod; Plasencia, Diego Martinez

    2016-01-01

    We foresee a future where energy in our mobile devices can be shared and redistributed to suit our current task needs. Many of us are beginning to carry multiple mobile devices and we seek to re-evaluate the traditional view of a mobile device as only accepting energy. In our vision, we can...... leverage the energy stored in our devices to wirelessly distribute energy between our friends, family, colleagues and strangers devices. In this paper we explore the opportunities and interactions presented by such spontaneous energy transfer interactions and present some envisaged collaborative energy...

  2. Virtually connected, practically mobile

    OpenAIRE

    Perry, M.; Brodie, J.

    2006-01-01

    This is the post-print version of the Chapter. The official published version can be accessed from the links below - Copyright @ 2006 Springer This chapter addresses a central issue in studies of mobile work and mobile technology – what is the work of mobile workers, and how do they use the resources that they have to undertake this work (i.e. the work they have to do in order to do their work)? In contrast to many of the other papers in this collection, the objective of this chapter is to...

  3. Utopias of Mobilities

    DEFF Research Database (Denmark)

    Jensen, Ole B.; Freudendal-Pedersen, Malene

    2012-01-01

    and visions as ‘prisms’ for the contemporary mobility debate in order to get closer to new imaginaries of technologies, complex systems and cultural change. The chapter is structured in five parts. After the introduction, part two discusses utopian and critical perspectives within urbanism in order......Contemporary global challenges to the distribution and organization of mobilities require new ways of envisioning and imagining to bring forward the discussion about new visions and thus policies of future mobilities. This chapter explores the imaginary visioning by using earlier utopian thoughts...

  4. Mobile Context Toolbox

    DEFF Research Database (Denmark)

    Stopczynski, Arkadiusz; Larsen, Jakob Eg; Skomail, Lukasz

    2010-01-01

    In this paper we describe an open framework utilizing sensors and application data on the Maemo mobile platform enabling rapid prototyping of context-aware mobile applications. The framework has an extensible layered architecture allowing new hardware and software sensors and features to be added...... to the context framework. We present initial results from in-the-wild experiments where contextual data was acquired using the tool. In the experiments 6 participants were using a Nokia N900 mobile phone continuously with a logger application for an average of 33 days. The study has provided valuable insights...

  5. Data mining mobile devices

    CERN Document Server

    Mena, Jesus

    2013-01-01

    With today's consumers spending more time on their mobiles than on their PCs, new methods of empirical stochastic modeling have emerged that can provide marketers with detailed information about the products, content, and services their customers desire.Data Mining Mobile Devices defines the collection of machine-sensed environmental data pertaining to human social behavior. It explains how the integration of data mining and machine learning can enable the modeling of conversation context, proximity sensing, and geospatial location throughout large communities of mobile users

  6. Mobile radio channels

    CERN Document Server

    Pätzold, Matthias

    2011-01-01

    Providing a comprehensive overview of the modelling, analysis and simulation of mobile radio channels, this book gives a detailed understanding of fundamental issues and examines state-of-the-art techniques in mobile radio channel modelling. It analyses several mobile fading channels, including terrestrial and satellite flat-fading channels, various types of wideband channels and advanced MIMO channels, providing a fundamental understanding of the issues currently being investigated in the field. Important classes of narrowband, wideband, and space-time wireless channels are explored in deta

  7. Mobile networks architecture

    CERN Document Server

    Perez, Andre

    2013-01-01

    This book explains the evolutions of architecture for mobiles and summarizes the different technologies:- 2G: the GSM (Global System for Mobile) network, the GPRS (General Packet Radio Service) network and the EDGE (Enhanced Data for Global Evolution) evolution;- 3G: the UMTS (Universal Mobile Telecommunications System) network and the HSPA (High Speed Packet Access) evolutions:- HSDPA (High Speed Downlink Packet Access),- HSUPA (High Speed Uplink Packet Access),- HSPA+;- 4G: the EPS (Evolved Packet System) network.The telephone service and data transmission are the

  8. Mobile communication and intermediality

    DEFF Research Database (Denmark)

    Helles, Rasmus

    2013-01-01

    The article argues the importance of intermediality as a concept for research in mobile communication and media. The constant availability of several, partially overlapping channels for communication (texting, calls, email, Facebook, etc.) requires that we adopt an integrated view of the various...... communicative affordances of mobile devices in order to understand how people choose between them for different purposes. It is argued that mobile communication makes intermediality especially central, as the choice of medium is detached from the location of stationary media and begins to follow the user across...

  9. Windows Azure mobile services

    CERN Document Server

    Johnson, Bruce

    2013-01-01

    Get up and running with Windows Azure Mobile Services Windows Azure Mobile Services (WAMS) is a turn-key backend solution for applications, mobile or otherwise, to utilize structured storage in the cloud. It includes basic data access functionality and built-in authentication with Microsoft Account, Facebook, Twitter and Google, as well as push notification to the client app. This compact, to the point book gives you just what you need to get up and running with these tools. Demonstrates how to add, update, delete and retrieve data using standard .NET classes or REST-based requestsDescribes h

  10. Anonymous Mobile Payment Solution

    Directory of Open Access Journals (Sweden)

    Alhaj Ali Jalila

    2015-09-01

    Full Text Available The evolution and increasing popularity of mobile handheld devices has led to the development of payment applications. The global acceptance of mobile payments is hindered by security and privacy concerns. One of the main problems evoked is the anonymity related with banking transactions. In this paper I propose a new secured architecture for mobile banking. Anonymity and privacy protection are the measures to be enhanced in order to satisfy people’s current needs. The banking platform must provide the highest level of security for messages exchanged between bank and the customer.

  11. Mobile ad hoc networking

    CERN Document Server

    John Wiley & Sons

    2004-01-01

    "Assimilating the most up-to-date information on research and development activities in this rapidly growing area, Mobile Ad Hoc Networking covers physical, data link, network, and transport layers, as well as application, security, simulation, and power management issues in sensor, local area, personal, and mobile ad hoc networks. Each of the book's sixteen chapters has been written by a top expert and discusses in-depth the most important topics in the field. Mobile Ad Hoc Networking is an excellent reference and guide for professionals seeking an in-depth examination of topics that also provides a comprehensive overview of the current state-of-the-art."--Jacket.

  12. Increasing clinical presence of mobile communication technology: avoiding the pitfalls.

    Science.gov (United States)

    Visvanathan, Akila; Gibb, Alan P; Brady, Richard R W

    2011-10-01

    Mobile communication technologies are employed in many diverse areas of healthcare delivery to provide improved quality and efficiency of communication and facilitate increased rapidity of data or information transfer. Mobile phones enable healthcare professionals to possess a portable platform from which to provide many healthcare-related applications and are a popular means to directly communicate with colleagues and patients. As involvement of mobile communication technology in healthcare delivery continues to rapidly expand, there are also important considerations of relevance to patient safety and security as a result. Here, we review the previous evidence of reported clinical risks associated with mobile communication technology, such as electromagnetic interference, confidentiality and data security, distraction/noise, infection control, and cross contamination. In conclusion, although mobile phones provide much putative potential improvement to healthcare delivery, further evaluation and research are required to both inform and protect health professionals and users of such technology in the healthcare environment and provide the evidence base to support the provision of clear and comprehensive guidelines.

  13. Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis

    Science.gov (United States)

    d'Amaro, Rocca; Scheidegger, Rolf; Blumer, Susan; Pazera, Pawel; Katsaros, Christos; Graf, Daniel; Chiquet, Matthias

    2012-01-01

    Cleft palate is a common birth defect in humans. Elevation and fusion of paired palatal shelves are coordinated by growth and transcription factors, and mutations in these can cause malformations. Among the effector genes for growth factor signaling are extracellular matrix (ECM) glycoproteins. These provide substrates for cell adhesion (e.g., fibronectin, tenascins), but also regulate growth factor availability (e.g., fibrillins). Cleft palate in Bmp7 null mouse embryos is caused by a delay in palatal shelf elevation. In contrast, palatal shelves of Tgf-β3 knockout mice elevate normally, but a cleft develops due to their failure to fuse. However, nothing is known about a possible functional interaction between specific ECM proteins and Tgf-β/Bmp family members in palatogenesis. To start addressing this question, we studied the mRNA and protein distribution of relevant ECM components during secondary palate development, and compared it to growth factor expression in wildtypewild type and mutant mice. We found that fibrillin-2 (but not fibrillin-1) mRNA appeared in the mesenchyme of elevated palatal shelves adjacent to the midline epithelial cells, which were positive for Tgf-β3 mRNA. Moreover, midline epithelial cells started expressing fibronectin upon contact of the two palatal shelves. These findings support the hypothesis that fibrillin-2 and fibronectin are involved in regulating the activity of Tgf-β3 at the fusing midline. In addition, we observed that tenascin-W (but not tenascin-C) was misexpressed in palatal shelves of Bmp7-deficient mouse embryos. In contrast to tenascin-C, tenascin-W secretion was strongly induced by Bmp7 in embryonic cranial fibroblasts in vitro. These results are consistent with a putative function for tenascin-W as a target of Bmp7 signaling during palate elevation. Our results indicate that distinct ECM proteins are important for morphogenesis of the secondary palate, both as downstream effectors and as regulators of Tgf

  14. Septal Junctions in Filamentous Heterocyst-Forming Cyanobacteria.

    Science.gov (United States)

    Flores, Enrique; Herrero, Antonia; Forchhammer, Karl; Maldener, Iris

    2016-02-01

    In the filaments of heterocyst-forming cyanobacteria, septal junctions that traverse the septal peptidoglycan join adjacent cells, allowing intercellular communication. Perforations in the septal peptidoglycan have been observed, and proteins involved in the formation of such perforations and putative protein components of the septal junctions have been identified, but their relationships are debated.

  15. Mobile Internet: Politics of Mobile Code and Networks

    NARCIS (Netherlands)

    L. Mosemghvdlishvili (Lela)

    2015-01-01

    markdownabstract__Abstract__ The term mobile internet refers to accessing the internet through (cellular) mobile devices and represents the convergence of mobile telephony, internet services, and personal computing. Whereas iMode (mobile internet and data services) was introduced in Japan as long a

  16. Research in Mobile Intelligence Mobile Computing and Computational Intelligence

    CERN Document Server

    Yang, Laurence T

    2010-01-01

    * Focuses on learning patterns and knowledge from data generated by mobile users and mobile technology. * Covers research and application issues in applying computational intelligence applications to mobile computing. * Delivers benefits to a wide range of applications. * Introduces the state of the art of computational intelligence to the mobile paradigm

  17. Mobile Internet: Politics of Mobile Code and Networks

    NARCIS (Netherlands)

    L. Mosemghvdlishvili (Lela)

    2015-01-01

    markdownabstract__Abstract__ The term mobile internet refers to accessing the internet through (cellular) mobile devices and represents the convergence of mobile telephony, internet services, and personal computing. Whereas iMode (mobile internet and data services) was introduced in Japan as long a

  18. jQuery Mobile

    CERN Document Server

    Reid, Jon

    2011-01-01

    Native apps have distinct advantages, but the future belongs to mobile web apps that function on a broad range of smartphones and tablets. Get started with jQuery Mobile, the touch-optimized framework for creating apps that look and behave consistently across many devices. This concise book provides HTML5, CSS3, and JavaScript code examples, screen shots, and step-by-step guidance to help you build a complete working app with jQuery Mobile. If you're already familiar with the jQuery JavaScript library, you can use your existing skills to build cross-platform mobile web apps right now. This b

  19. Are mobile phones harmful?

    DEFF Research Database (Denmark)

    Blettner, M; Berg, Gabriele

    2000-01-01

    in cells. Implications of these experimental results on public health concerns are yet unclear. Few epidemiological studies are available on the use of mobile phones or on the radiofrequency exposure and the development of cancer. Most of these studies have no or little quantitative exposure data......There is increasing public interest in health risks of mobile phone use. Although there is a vast body of material on the biological effects of radiofrequency fields, current risk assessment is still limited. The article describes several hypotheses and results of biological effects such as thermal...... and they are limited by the small number of observations. Large epidemiological studies are necessary in order to investigate the use of mobile phones on the development of cancer. It should be emphasized that even a small elevated risk may have a large implication for public health, as the use of mobile phones...

  20. Talk, Mobility and Materialities

    DEFF Research Database (Denmark)

    McIlvenny, Paul

    The intersection of the quotidian practices of social interaction, learning and mobility outside of the classroom – for example, the ways in which talk shapes how children learn to be actively mobile – has been little studied until recently. This paper develops a social interactional approach...... to analysing talk and mobile action in what are arguably two quintessentially Nordic mobility practices, namely cycling and skiing. More specifically the focus is on investigating and comparing how a child learns to cycle in a bike-friendly urban infrastructure, and how a child learns to ski cross...... is collaboratively constructed in interaction by the participants as part and parcel of their kinaesthetic experience of the respective material environment and infrastructure. Especially when skiing, the more malleable snowscape is (re)territorialised by laying down tracks, which can be reused by participants, both...

  1. Mobile Learning Applications Audit

    Directory of Open Access Journals (Sweden)

    Paul POCATILU

    2010-01-01

    Full Text Available While mobile learning (m-learning applications have proven their value in educational activities, there is a need to measure their reliability, accessibility and further more their trustworthiness. Mobile devices are far more vulnerable then classic computers and present inconvenient interfaces due to their size, hardware limitations and their mobile connectivity. Mobile learning applications should be audited to determine if they should be trusted or not, while multimedia contents like automatic speech recognition (ASR can improve their accessibility. This article will start with a brief introduction on m-learning applications, then it will present the audit process for m-learning applications, it will iterate their specific security threats, it will define the ASR process, and it will elaborate how ASR can enhance accessibility of these types of applications.

  2. Intergenerational earnings mobilities

    DEFF Research Database (Denmark)

    Hussain, Azhar; Munk, Martin D.; Bonke, Jens

    2009-01-01

    This article gives various estimates of intergenerational earnings mobility by applying different earning periods, age brackets, and earning components. The methodology enables us to investigate how sensitive results are to different delimitations and, thereby, to make more accurate international...

  3. Mobility: A Critical Appraisal

    DEFF Research Database (Denmark)

    McIntosh, James; D. Munk, Martin

    This paper deals with the methodological and statistical problems that have arisen in the literature which analyzes social and economic mobility. These problems are considered in the context of both simulated data and Danish mobility data on social classes and earnings. We first show...... that traditional methods used in the analysis of mobility tables will produce biased and, hence, unreliable estimates of the model's parameters if there are individual attributes that can be observed by the researcher like ability, for example. We also show that the schemata that are used to define social classes...... based on occupational groupings can be tested using classical statistical methods. Using Danish mobility data we found that there were plausible situations where these schemata are rejected by the data. A model of income was developed whose structural parameters could be estimated consistently...

  4. Cooperative Mobile Web Browsing

    DEFF Research Database (Denmark)

    Perrucci, GP; Fitzek, FHP; Zhang, Qi

    2009-01-01

    This paper advocates a novel approach for mobile web browsing based on cooperation among wireless devices within close proximity operating in a cellular environment. In the actual state of the art, mobile phones can access the web using different cellular technologies. However, the supported data...... extension of current technology, we propose a novel architecture where mobile phones are grouped together in clusters, using a short-range communication such as Bluetooth, sharing, and accumulating their cellular capacity. The accumulated data rate resulting from collaborative interactions over short...... rates are not sufficient to cope with the ever increasing trafic requirements resulting from advanced and rich content services. Extending the state of the art, higher data rates can only be achieved by increasing complexity, cost, and energy consumption of mobile phones. In contrast to the linear...

  5. Prioritization of putative metabolite identifications in LC-MS/MS experiments using a computational pipeline.

    Science.gov (United States)

    Zhou, Bin; Xiao, Jun Feng; Ressom, Habtom W

    2013-01-01

    One of the major bottle-necks in current LC-MS-based metabolomic investigations is metabolite identification. An often-used approach is to first look up metabolites from databases through peak mass, followed by verification of the obtained putative identifications using MS/MS data. However, the mass-based search may provide inappropriate putative identifications when the observed peak is from isotopes, fragments, or adducts. In addition, a large fraction of peaks is often left with multiple putative identifications. To differentiate these putative identifications, manual verification of metabolites through comparison between biological samples and authentic compounds is necessary. However, such experiments are laborious, especially when multiple putative identifications are encountered. It is desirable to use computational approaches to obtain more reliable putative identifications and prioritize them before performing experimental verification of the metabolites. In this article, a computational pipeline is proposed to assist metabolite identification with improved metabolome coverage and prioritization capability. Multiple publicly available software tools and databases, along with in-house developed algorithms, are utilized to fully exploit the information acquired from LC-MS/MS experiments. The pipeline is successfully applied to identify metabolites on the basis of LC-MS as well as MS/MS data. Using accurate masses, retention time values, MS/MS spectra, and metabolic pathways/networks, more appropriate putative identifications are retrieved and prioritized to guide subsequent metabolite verification experiments.

  6. Telocytes and putative stem cells in the lungs: electron microscopy, electron tomography and laser scanning microscopy.

    Science.gov (United States)

    Popescu, Laurentiu M; Gherghiceanu, Mihaela; Suciu, Laura C; Manole, Catalin G; Hinescu, Mihail E

    2011-09-01

    This study describes a novel type of interstitial (stromal) cell - telocytes (TCs) - in the human and mouse respiratory tree (terminal and respiratory bronchioles, as well as alveolar ducts). TCs have recently been described in pleura, epicardium, myocardium, endocardium, intestine, uterus, pancreas, mammary gland, etc. (see www.telocytes.com ). TCs are cells with specific prolongations called telopodes (Tp), frequently two to three per cell. Tp are very long prolongations (tens up to hundreds of μm) built of alternating thin segments known as podomers (≤ 200 nm, below the resolving power of light microscope) and dilated segments called podoms, which accommodate mitochondria, rough endoplasmic reticulum and caveolae. Tp ramify dichotomously, making a 3-dimensional network with complex homo- and heterocellular junctions. Confocal microscopy reveals that TCs are c-kit- and CD34-positive. Tp release shed vesicles or exosomes, sending macromolecular signals to neighboring cells and eventually modifying their transcriptional activity. At bronchoalveolar junctions, TCs have been observed in close association with putative stem cells (SCs) in the subepithelial stroma. SCs are recognized by their ultrastructure and Sca-1 positivity. Tp surround SCs, forming complex TC-SC niches (TC-SCNs). Electron tomography allows the identification of bridging nanostructures, which connect Tp with SCs. In conclusion, this study shows the presence of TCs in lungs and identifies a TC-SC tandem in subepithelial niches of the bronchiolar tree. In TC-SCNs, the synergy of TCs and SCs may be based on nanocontacts and shed vesicles.

  7. Insilico Analysis unveils Putative Metabolic Pathways and Essential Genes within Leishmania donovani ‘Orfeome’

    Directory of Open Access Journals (Sweden)

    Nithin eRavooru

    2014-08-01

    Full Text Available Leishmaniasis is a parasitic disease caused by the protozoan Leishmania, which is active in two broad forms namely, Visceral Leishmaniasis (VL or Kala Azar and Cutaneous Leishmaniasis (CL. The disease is most prevalent in the tropical regions and poses a threat to more than 70 countries across the globe. In the Indian subcontinent, about 200 million people are estimated to be at risk of developing VL and this area harbours an estimated 67% of the global VL disease burden. The state of Bihar alone has captured almost 50% of the total cases in the Indian region. While no vaccination exists, several pentavalent antimonials and drugs like Paromomycin, Amphotericin, Miltefosine etc., are used in the treatment of Leishmaniasis. However, due to low efficacy of these drugs and the resistance developed by the bug to these medications, there is an urgent need to look into species specific targets. The proteome information available suggests that among the 7960 proteins, a staggering 65% of it remains to be annotated with clarity.Hence, in the present study, we have demonstrated a protocol to integrate the seqeunce and functional information from various databases, such as GO, PFAM, KEGG, String DB, COG and DEG, to assign putative functions to many of the hypothetical seqeucences present in this proteome. These crucial information related to pathways and essential genes show promise for exploring the design strategies towards developing drugs, to tackle this notorious parasitic disease.

  8. Structural analysis of a putative SAM-dependent methyltransferase, YtqB, from Bacillus subtilis.

    Science.gov (United States)

    Park, Sun Cheol; Song, Wan Seok; Yoon, Sung-il

    2014-04-18

    S-adenosyl-L-methionine (SAM)-dependent methyltransferases (MTases) methylate diverse biological molecules using a SAM cofactor. The ytqB gene of Bacillus subtilis encodes a putative MTase and its biological function has never been characterized. To reveal the structural features and the cofactor binding mode of YtqB, we have determined the crystal structures of YtqB alone and in complex with its cofactor, SAM, at 1.9 Å and 2.2 Å resolutions, respectively. YtqB folds into a β-sheet sandwiched by two α-helical layers, and assembles into a dimeric form. Each YtqB monomer contains one SAM binding site, which shapes SAM into a slightly curved conformation and exposes the reactive methyl group of SAM potentially to a substrate. Our comparative structural analysis of YtqB and its homologues indicates that YtqB is a SAM-dependent class I MTase, and provides insights into the substrate binding site of YtqB.

  9. Characterization of a Novel Putative S-Adenosylmethionine Decarboxylase-Like Protein from Leishmania donovani.

    Directory of Open Access Journals (Sweden)

    Saurabh Pratap Singh

    Full Text Available In addition to the S-adenosylmethionine decarboxylase (AD present in all organisms, trypanosomatids including Leishmania spp. possess an additional copy, annotated as the putative S-adenosylmethionine decarboxylase-like proenzyme (ADL. Phylogenetic analysis confirms that ADL is unique to trypanosomatids and has several unique features such as lack of autocatalytic cleavage and a distinct evolutionary lineage, even from trypanosomatid ADs. In Trypanosoma ADL was found to be enzymaticaly dead but plays an essential regulatory role by forming a heterodimer complex with AD. However, no structural or functional information is available about ADL from Leishmania spp. Here, in this study, we report the cloning, expression, purification, structural and functional characterization of Leishmania donovani (L. donovani ADL using biophysical, biochemical and computational techniques. Biophysical studies show that, L. donovani ADL binds S-adenosylmethionine (SAM and putrescine which are natural substrates of AD. Computational modeling and docking studies showed that in comparison to the ADs of other organisms including human, residues involved in putrescine binding are partially conserved while the SAM binding residues are significantly different. In silico protein-protein interaction study reveals that L. donovani ADL can interact with AD. These results indicate that L. donovani ADL posses a novel substrate binding property and may play an essential role in polyamine biosynthesis with a different mode of function from known proteins of the S-adenosylmethionine decarboxylase super family.

  10. [The (putative) pathological impact of fibromyalgia on the orofacial system].

    Science.gov (United States)

    de Baat, C; Gerritsen, A E; de Baat-Ananta, M; de Baat, P

    2016-03-01

    Fibromyalgia is a syndrome without apparent aetiology, characterised by pain, fatigue, memory disorders, mood disorders, and sleep disturbances. The syndrome is considered to be one of the rheumatic diseases. In the general population, the prevalence varies from 2 to 8%, with a women-men ratio of about 2:1. Suspicion of fibromyalgia arises when a patient has pain at multiple locations that cannot be attributed to trauma or inflammation, and when the pain is especially musculoskeletal. Primary management includes explaining the syndrome and offering reassurance. In addition, one can also attempt to increase mobility, avoid overloading, and improve physical condition and the level of activity, and to activate problem-solving skills. Subsequently, behavioural therapy and pharmacotherapy may be considered. The most important manifestations of fibromyalgia in the orofacial and occlusal system seem to be temporomandibular dysfunction, headache, xerostomia, hyposalivation, burning mouth and dysgeusia. However, with respect to the precise relation of fibromyalgia with the orofacial system, much needs to be elucidated.

  11. Mobile Database System: Role of Mobility on the Query Processing

    CERN Document Server

    Sharma, Samidha Dwivedi

    2010-01-01

    The rapidly expanding technology of mobile communication will give mobile users capability of accessing information from anywhere and any time. The wireless technology has made it possible to achieve continuous connectivity in mobile environment. When the query is specified as continuous, the requesting mobile user can obtain continuously changing result. In order to provide accurate and timely outcome to requesting mobile user, the locations of moving object has to be closely monitored. The objective of paper is to discuss the problem related to the role of personal and terminal mobility and query processing in the mobile environment.

  12. A Simulative Study on the Performance Evaluation for Simultaneous and Successive Mobility for Mobile IPv6

    Directory of Open Access Journals (Sweden)

    Ibrahim Abdullah

    2010-01-01

    Full Text Available Problem statement: Mobile Internet Protocol (MIP is the forms of the backbone for next generation wireless internet technology to provide uninterrupted network service while a node on the move. The original MIP use Home Agent to forward the traffic. Thus, it does not have problem with simultaneous mobility, i.e., the special case when both end nodes are mobile and move at about the same time. However, MIPv6 uses location binding updates which sent directly to a correspondent node to complete its registration. Thus, MIPv6 is vulnerable to the simultaneous mobility problem which leads to the interruption of communication and cause messages lost, especially protocol messages. Approach: This article analyzed the simultaneous and successive fast mobility problems and handover latency. Then propose a mechanism by adopting technique to the mobile node’s Home Agent. Results: We simulated the proposed scheme using ns-2 and we present and analyze the performance testing for the proposed scheme by comparing it with the conventional MIPv6. Conclusion: Simulation results showed this scheme can effectively resolve simultaneous and successive mobility problems and reduce the handover latency which is affected by long registration time.

  13. Mobile Phone on Campus

    Institute of Scientific and Technical Information of China (English)

    周成

    2005-01-01

    Communication revolution has brought a great convenience to modem society and people. Especially, the occurrence of mobile phone, in away, has changed the world where we live. Maybe the mobile phone was a luxury for only a decade ago. Now, it is no exaggeration4 to say that the difference between the parts and the present is as vast as that between earth and heaven. With no exception6, campus students also fall into the category called “cell-phone school”.

  14. Mobile-Phone Microscopes

    Institute of Scientific and Technical Information of China (English)

    程杰

    2008-01-01

    Simple accessories could turn mobile phones into useful medical devices Robi Marrmari stares intently at the screen of his mobile phone.The student is not squinting to tap out yet another daft text message,but looking carefully for the faint blue dots that are the tell-tale diagnostic signature of malaria.Mr.Maamari is a member of a research team led by Dan Fletcher,a professor of bioengineering

  15. Plant Mobile Small RNAs

    OpenAIRE

    Dunoyer, Patrice; Melnyk, Charles; Molnar, Attila; Slotkin, R Keith

    2013-01-01

    In plants, RNA silencing is a fundamental regulator of gene expression, heterochromatin formation, suppression of transposable elements, and defense against viruses. The sequence specificity of these processes relies on small noncoding RNA (sRNA) molecules. Although the spreading of RNA silencing across the plant has been recognized for nearly two decades, only recently have sRNAs been formally demonstrated as the mobile silencing signals. Here, we discuss the various types of mobile sRNA mol...

  16. Social Perspectives on Mobility

    DEFF Research Database (Denmark)

    Uth Thomsen, Thyra; Gudmundsson, Henrik; Drewes Nielsen, Lise

    Globalisation is heavily dependent on physical transport, as people and goods travel over longer distances and with higher frequency. Movement and mobility have become integrated parts of late modern identity and practice, and a state of flux can be sensed everywhere. Bringing together the latest...... for both research and policy. In the final section of the book new visions for research into sustainability and mobility are laid out....

  17. Brave New Mobile World

    Institute of Scientific and Technical Information of China (English)

    Maya; Reid

    2011-01-01

    An oral history of the mobile app boom in East Africa APPS are taking East Africa by storm.As mobile phone penetration rates increase,technologists and software developers in the region are scrambling to provide bigger and better services for an evergrowing consumer base. At the center of this flurry of activity is Nairobi,Kenya. But Dar Es Salaam in Tanzania and Uganda’s

  18. Mobile Agents - Smart Messages

    OpenAIRE

    Hurst, Leon; Cunningham, Padraig

    1997-01-01

    Wireless communication with Mobile Computing devices is known to be problematic. It is very different in character from conventional communication over wired networks. Since many distributed applications make assumptions about network characteristics, they may not be used in a hostile mobile environment. We are proposing a new kind of messaging system which incorporates adaptive behaviour into the messages themselves. We call these `Smart Messages?, and implement them using ...

  19. Mobile systems development

    DEFF Research Database (Denmark)

    Hosbond, Jens Henrik

    2005-01-01

    This paper takes a systems development perspective on mobility, building on preliminary findings of an on-going multiple case study covering 7 companies. The questions driving this paper are: What are the challenges facing development practice in the mobile industry, how do they affect practice...... and a development dimension. Finally, implications stemming from these challenges are discussed and issues inviting for future research are proposed....

  20. Mobile Uninterruptible Power Supply

    Science.gov (United States)

    Mears, Robert L.

    1990-01-01

    Proposed mobile unit provides 20 kVA of uninterruptible power. Used with mobile secondary power-distribution centers to provide power to test equipment with minimal cabling, hazards, and obstacles. Wheeled close to test equipment and system being tested so only short cable connections needed. Quickly moved and set up in new location. Uninterruptible power supply intended for tests which data lost or equipment damaged during even transient power failure.

  1. REST based mobile applications

    Science.gov (United States)

    Rambow, Mark; Preuss, Thomas; Berdux, Jörg; Conrad, Marc

    2008-02-01

    Simplicity is the major advantage of REST based webservices. Whereas SOAP is widespread in complex, security sensitive business-to-business aplications, REST is widely used for mashups and end-user centric applicatons. In that context we give an overview of REST and compare it to SOAP. Furthermore we apply the GeoDrawing application as an example for REST based mobile applications and emphasize on pros and cons for the use of REST in mobile application scenarios.

  2. Soft Soil Mobility

    Science.gov (United States)

    2016-02-11

    also presented and defined . 15. SUBJECT TERMS trafficability, floatation, traction, vehicle cone index, mobility 16. SECURITY...Atlantic Treaty Organization (NATO) Reference Mobility Model (NRMM) are also presented and defined . 1.2 Background. a. Throughout history terrain...The use of brand names does not constitute endorsement by the Army or any other agency of the Federal Government, nor does it imply that it is

  3. Mobile Software Testing – Automated Test Case Design Strategies

    Directory of Open Access Journals (Sweden)

    Selvam R,

    2011-04-01

    Full Text Available Mobile devices are poised to challenge PCs as the application platform of choice, with 500 million mobile internet devices expected to ship in 2012 compared to 150 million PCs. The convergence ofall digital devices into mobile platform model augments the software companies, software developer, and venture capitalist firms to turn their focus into mobile application platform (for example mobile social networking application like face book and mobile VOIP like Skype a futuristic platform for increased revenue, new challenges and growth potential. But the commercial success of these applications depends on their working smoothly and securely on a wide variety of handheld devices and wireless networks. More and more virtual mobile application stores are built on the web. The web itself is in the transforming form to adapt to the mobile devices to thrive on. The sudden growth in the mobile application and the complexity in the divergence of the devices that uses these applications present increased challenges and opportunities for the software testing companies and software testers to conquerthis small device. Performing such testing quickly and cost-effectively greatly expands the market for such applications. This paper deals the nuances of Automated Test Case Design Strategies for Mobile Software Testing.

  4. Learning for intelligent mobile robots

    Science.gov (United States)

    Hall, Ernest L.; Liao, Xiaoqun; Alhaj Ali, Souma M.

    2003-10-01

    Unlike intelligent industrial robots which often work in a structured factory setting, intelligent mobile robots must often operate in an unstructured environment cluttered with obstacles and with many possible action paths. However, such machines have many potential applications in medicine, defense, industry and even the home that make their study important. Sensors such as vision are needed. However, in many applications some form of learning is also required. The purpose of this paper is to present a discussion of recent technical advances in learning for intelligent mobile robots. During the past 20 years, the use of intelligent industrial robots that are equipped not only with motion control systems but also with sensors such as cameras, laser scanners, or tactile sensors that permit adaptation to a changing environment has increased dramatically. However, relatively little has been done concerning learning. Adaptive and robust control permits one to achieve point to point and controlled path operation in a changing environment. This problem can be solved with a learning control. In the unstructured environment, the terrain and consequently the load on the robot"s motors are constantly changing. Learning the parameters of a proportional, integral and derivative controller (PID) and artificial neural network provides an adaptive and robust control. Learning may also be used for path following. Simulations that include learning may be conducted to see if a robot can learn its way through a cluttered array of obstacles. If a situation is performed repetitively, then learning can also be used in the actual application. To reach an even higher degree of autonomous operation, a new level of learning is required. Recently learning theories such as the adaptive critic have been proposed. In this type of learning a critic provides a grade to the controller of an action module such as a robot. The creative control process is used that is "beyond the adaptive critic." A

  5. Function-Biased Choice of Additives for Optimization of Protein Crystallization: The Case of the Putative Thioesterase PA5185 from Pseudomonas aeruginosa PAO1

    Energy Technology Data Exchange (ETDEWEB)

    Chruszcz, Maksymilian; Zimmerman, Matthew D.; Wang, Shuren; Koclega, Katarzyna D.; Zheng, Heping; Evdokimova, Elena; Kudritska, Marina; Cymborowski, Marcin; Savchenko, Alexei; Edwards, Aled; Minor, Wladek (Toronto); (UV)

    2009-09-15

    The crystal structure of PA5185, a putative thioesterase from Pseudomonas aeruginosa strain PAO1, was solved using multi-wavelength anomalous diffraction to 2.4 {angstrom}. Analysis of the structure and information about the putative function of the protein were used to optimize crystallization conditions. The crystal growth was optimized by applying additives with chemical similarity to a fragment of a putative PA5185 substrate (CoA or its derivative). Using new crystallization conditions containing this function-biased set of additives, several new crystal forms were produced, and structures of three of them (in three different space groups) were determined. One of the new crystal forms had an improved resolution limit of 1.9 {angstrom}, and another displayed an alternative conformation of the highly conserved loop containing Asn26, which could play a physiological role. Surprisingly, none of the additives were ordered in the crystal structures. Application of function-biased additives could be used as a standard optimization protocol for producing improved diffraction, or new crystal forms, which may lead to better understanding of the biological functions of proteins.

  6. A mobile and portable trusted computing platform

    Directory of Open Access Journals (Sweden)

    Nepal Surya

    2011-01-01

    Full Text Available Abstract The mechanism of establishing trust in a computing platform is tightly coupled with the characteristics of a specific machine. This limits the portability and mobility of trust as demanded by many emerging applications that go beyond the organizational boundaries. In order to address this problem, we propose a mobile and portable trusted computing platform in a form of a USB device. First, we describe the design and implementation of the hardware and software architectures of the device. We then demonstrate the capabilities of the proposed device by developing a trusted application.

  7. Technologies of Mobility in the Americas: Introduction

    DEFF Research Database (Denmark)

    2012-01-01

    . This relational approach to technology demonstrates that technology is neither a utopian nor a dystopian force driving the universe towards progress or involution. For all the contributors to this book, what mobile communication technologies like smart phones and spatial mobility technologies like cars and ferry......Technics, technicians, and techniques form the three basic cornerstones of what this book is about. Whether it is cell phones or airplanes, passengers or magazine advertisements, what the chapters collected here have in common is a basic orientation towards technology as a set of relations...

  8. Extra- and intracellular lactose catabolism in Penicillium chrysogenum: phylogenetic and expression analysis of the putative permease and hydrolase genes.

    Science.gov (United States)

    Jónás, Ágota; Fekete, Erzsébet; Flipphi, Michel; Sándor, Erzsébet; Jäger, Szilvia; Molnár, Ákos P; Szentirmai, Attila; Karaffa, Levente

    2014-07-01

    Penicillium chrysogenum is used as an industrial producer of penicillin. We investigated its catabolism of lactose, an abundant component of whey used in penicillin fermentation, comparing the type strain NRRL 1951 with the high producing strain AS-P-78. Both strains grew similarly on lactose as the sole carbon source under batch conditions, exhibiting almost identical time profiles of sugar depletion. In silico analysis of the genome sequences revealed that P. chrysogenum features at least five putative β-galactosidase (bGal)-encoding genes at the annotated loci Pc22g14540, Pc12g11750, Pc16g12750, Pc14g01510 and Pc06g00600. The first two proteins appear to be orthologs of two Aspergillus nidulans family 2 intracellular glycosyl hydrolases expressed on lactose. The latter three P. chrysogenum proteins appear to be distinct paralogs of the extracellular bGal from A. niger, LacA, a family 35 glycosyl hydrolase. The P. chrysogenum genome also specifies two putative lactose transporter genes at the annotated loci Pc16g06850 and Pc13g08630. These are orthologs of paralogs of the gene encoding the high-affinity lactose permease (lacpA) in A. nidulans for which P. chrysogenum appears to lack the ortholog. Transcript analysis of Pc22g14540 showed that it was expressed exclusively on lactose, whereas Pc12g11750 was weakly expressed on all carbon sources tested, including D-glucose. Pc16g12750 was co-expressed with the two putative intracellular bGal genes on lactose and also responded on L-arabinose. The Pc13g08630 transcript was formed exclusively on lactose. The data strongly suggest that P. chrysogenum exhibits a dual assimilation strategy for lactose, simultaneously employing extracellular and intracellular hydrolysis, without any correlation to the penicillin-producing potential of the studied strains.

  9. Experimental Evidence for a Revision in the Annotation of Putative Pyridoxamine 5'-Phosphate Oxidases P(N/MP from Fungi.

    Directory of Open Access Journals (Sweden)

    Tatiana Domitrovic

    Full Text Available Pyridoxinamine 5'-phosphate oxidases (P(N/MP oxidases that bind flavin mononucleotide (FMN and oxidize pyridoxine 5'-phosphate or pyridoxamine 5'-phosphate to form pyridoxal 5'-phosphate (PLP are an important class of enzymes that play a central role in cell metabolism. Failure to generate an adequate supply of PLP is very detrimental to most organisms and is often clinically manifested as a neurological disorder in mammals. In this study, we analyzed the function of YLR456W and YPR172W, two homologous genes of unknown function from S. cerevisiae that have been annotated as putative P(N/MP oxidases based on sequence homology. Different experimental approaches indicated that neither protein catalyzes PLP formation nor binds FMN. On the other hand, our analysis confirmed the enzymatic activity of Pdx3, the S. cerevisiae protein previously implicated in PLP biosynthesis by genetic and structural characterization. After a careful sequence analysis comparing the putative and confirmed P(N/MP oxidases, we found that the protein domain (PF01243 that led to the YLR456W and YPR172W annotation is a poor indicator of P(N/MP oxidase activity. We suggest that a combination of two Pfam domains (PF01243 and PF10590 present in Pdx3 and other confirmed P(N/MP oxidases would be a stronger predictor of this molecular function. This work exemplifies the importance of experimental validation to rectify genome annotation and proposes a revision in the annotation of at least 400 sequences from a wide variety of fungal species that are homologous to YLR456W and are currently misrepresented as putative P(N/MP oxidases.

  10. Isolation and characterization of a new chemokine receptor gene, the putative chicken CXCR1.

    Science.gov (United States)

    Li, Q J; Lu, S; Ye, R D; Martins-Green, M

    2000-10-31

    This study delineates the isolation and characterization of a novel chemokine receptor gene, the putative chicken CXC receptor 1 (cCXCR1). Using a human CXCR1 probe, we isolated several positive clones from a chicken genomic library. One of the clones contained a fragment of approximately 5000bp that hybridized strongly with the hCXCR1 probe. This fragment was sequenced and subjected to a variety of computer analyses. The open reading frame for this gene predicts a seven transmembrane domain protein with all the characteristics of a chemokine receptor and with 67% sequence homology to hCXCR1, 65% to hCXCR2 and also with considerable sequence homology to other human chemokine receptors such as hCXCR4 (50%), hCCR2 (49%) and hCCR1 (49%). However, the homology to a previously isolated potential G-protein-coupled receptor for chickens (AvCRL1) is only 47%. Using 5' RACE, two transcription initiation sites were identified suggesting the potential for the expression of two protein isoforms (I and II) in vivo. The promoter for the putative cCXCR1 contains a variety of consensus transcription factor binding elements that can potentially be involved in the expression of this chicken receptor upon stimulation by stress-inducing agents. RT-PCR analysis was used to determine the pattern of expression of the larger isoform (I) of this receptor in a variety of tissues. This form of the receptor is expressed primarily in the organs of the gastrointestinal tract, tissues that are frequently exposed to stress-inducing agents, but not in the central nervous system, tissues that are protected from insult by the blood barrier. Using the same RT-PCR approach we show that stress-inducing agents, such as 'first-hand' and 'second-hand' cigarette smoke components, tumor promoters and thrombin, differentially stimulate the expression of the isoform I in primary fibroblasts. Thrombin is an enzyme that plays many important roles in thrombosis, angiogenesis and wound healing and exposure to

  11. Functional characterisation of a putative rhamnogalacturonan II specific xylosyltransferase

    DEFF Research Database (Denmark)

    Madsen, Jack Egelund; Damager, Iben; Faber, Kirsten;

    2008-01-01

    An Arabidopsis thaliana gene, At1g56550, was expressed in Pichia pastoris and the recombinant protein was shown to catalyse transfer of d-xylose from UDP-alpha-d-xylose onto methyl alpha-l-fucoside. The product formed was shown by 1D and 2D (1)H NMR spectroscopy to be Me alpha-d-Xyl-(1,3)-alpha...

  12. Mobility and QoS Support in Mobile IP Networks

    Institute of Scientific and Technical Information of China (English)

    DUAN Lian; WU Wei-ling

    2004-01-01

    This paper presents the state of the art of the Quality of Service (QoS) and mobility support mechanisms for mobile IP networks, which includes the issues and challenges in QoS support, an overview of the Mobile IP protocol, a general description of the QoS and Mobility framework, and the End-To-End QoS architecture in the next-generation all-IP mobile network.

  13. INTERNET MOBILE USERS FROM ROMANIA AND MOBILE APPS

    OpenAIRE

    MIHAELA TUTUNEA

    2011-01-01

    The development of mobile technologies triggered also the development of the software industry for mobile devices. Any mobile phone, depending on its features, has preinstalled basic applications, which make it functional. Along these, the user can install more applications according to his needs. Must be noticed the current trend: companies developing and offering their own mobile applications, which can be downloaded directly from the mobile websites. The present study tries to identify the...

  14. The Potential of a Mobile Group Blog to Support Cultural Learning among Overseas Students

    Science.gov (United States)

    Shao, Yinjuan; Crook, Charles

    2015-01-01

    We explored the use of mobile social software, in the form of a mobile group blog, to assist cultural learning. The potential of using this technology for cultural adaptation among overseas students was examined as those students adapted to the everyday life of studying abroad. Two pilot studies and a successful field study of a mobile group blog…

  15. Mobility. Snapshot Report, Fall 2011

    Science.gov (United States)

    National Student Clearinghouse, 2011

    2011-01-01

    This paper presents information on student mobility for 2011. It offers data on the following: (1) Mobility Rates by Student Enrollment Status; (2) Mobile Student Enrollment at 2-/4-Year Institutions; and (3) Mobile Student Enrollment at Public/Private Institutions.

  16. Mastering jQuery mobile

    CERN Document Server

    Lambert, Chip

    2015-01-01

    You've started down the path of jQuery Mobile, now begin mastering some of jQuery Mobile's higher level topics. Go beyond jQuery Mobile's documentation and master one of the hottest mobile technologies out there. Previous JavaScript and PHP experience can help you get the most out of this book.

  17. Mobile library services best practices

    CERN Document Server

    Harmon, Charles

    2013-01-01

    Mobile Library Services provides 11 proven ways to reach out to mobile users and increase your library's relevance to their day-to-day lives. Librarians detail how they created mobile apps to how they went mobile on a shoestring budget. Written by public, academic, and special librarians, these 11 best practices offer models for libraries of every type and size.

  18. Interactive TV meets Mobile Computing

    OpenAIRE

    Rauschenbach, Uwe

    2005-01-01

    The talk presents some recent developments in interactive digital television and discusses the trends and challenges of bringing TV services to mobile devices. Two areas will be addressed: portable use of mobile devices to complement the TV set in the home and mobile TV services while on the move using mobile broadcasting technology.

  19. Mobility decline in old age

    DEFF Research Database (Denmark)

    Nilsson, C.J.; Siersma, V.; Mänty, Minna Regina

    2014-01-01

    BACKGROUND: Mobility-related fatigue and low socioeconomic position predicts mobility limitations and disability in old age, but the interplay between these two factors is unknown. To evaluate whether mobility-related fatigue is a stronger risk factor for mobility limitations in certain socioecon......BACKGROUND: Mobility-related fatigue and low socioeconomic position predicts mobility limitations and disability in old age, but the interplay between these two factors is unknown. To evaluate whether mobility-related fatigue is a stronger risk factor for mobility limitations in certain...... socioeconomic groups, the aim of this study was to examine the combined effect of mobility-related fatigue and socioeconomic position on mobility limitations in a prospective study among older Danish men and women. METHODS: Multivariate linear regression models with combined exposure variables using generalised...

  20. Implications of Galaxy Buildup for Putative IMF Variations in Massive Galaxies

    Science.gov (United States)

    Blancato, Kirsten; Genel, Shy; Bryan, Greg

    2017-08-01

    Recent observational evidence for initial mass function (IMF) variations in massive quiescent galaxies at z = 0 challenges the long-established paradigm of a universal IMF. While a few theoretical models relate the IMF to birth cloud conditions, the physical driver underlying these putative IMF variations is still largely unclear. Here we use post-processing analysis of the Illustris cosmological hydrodynamical simulation to investigate possible physical origins of IMF variability with galactic properties. We do so by tagging stellar particles in the simulation (each representing a stellar population of ≈ {10}6 {M}⊙ ) with individual IMFs that depend on various physical conditions, such as velocity dispersion, metallicity, or star formation rate, at the time and place in which the stars are formed. We then follow the assembly of these populations throughout cosmic time and reconstruct the overall IMF of each z = 0 galaxy from the many distinct IMFs it is composed of. Our main result is that applying the observed relations between IMF and galactic properties to the conditions at the star formation sites does not result in strong enough IMF variations between z = 0 galaxies. Steeper physical IMF relations are required for reproducing the observed IMF trends, and some stellar populations must form with more extreme IMFs than those observed. The origin of this result is the hierarchical nature of massive galaxy assembly, and it has implications for the reliability of the strong observed trends, for the ability of cosmological simulations to capture certain physical conditions in galaxies, and for theories of star formation aiming to explain the physical origin of a variable IMF.

  1. Zuotin, a putative Z-DNA binding protein in Saccharomyces cerevisiae

    Science.gov (United States)

    Zhang, S.; Lockshin, C.; Herbert, A.; Winter, E.; Rich, A.

    1992-01-01

    A putative Z-DNA binding protein, named zuotin, was purified from a yeast nuclear extract by means of a Z-DNA binding assay using [32P]poly(dG-m5dC) and [32P]oligo(dG-Br5dC)22 in the presence of B-DNA competitor. Poly(dG-Br5dC) in the Z-form competed well for the binding of a zuotin containing fraction, but salmon sperm DNA, poly(dG-dC) and poly(dA-dT) were not effective. Negatively supercoiled plasmid pUC19 did not compete, whereas an otherwise identical plasmid pUC19(CG), which contained a (dG-dC)7 segment in the Z-form was an excellent competitor. A Southwestern blot using [32P]poly(dG-m5dC) as a probe in the presence of MgCl2 identified a protein having a molecular weight of 51 kDa. The 51 kDa zuotin was partially sequenced at the N-terminal and the gene, ZUO1, was cloned, sequenced and expressed in Escherichia coli; the expressed zuotin showed similar Z-DNA binding activity, but with lower affinity than zuotin that had been partially purified from yeast. Zuotin was deduced to have a number of potential phosphorylation sites including two CDC28 (homologous to the human and Schizosaccharomyces pombe cdc2) phosphorylation sites. The hexapeptide motif KYHPDK was found in zuotin as well as in several yeast proteins, DnaJ of E.coli, csp29 and csp32 proteins of Drosophila and the small t and large T antigens of the polyoma virus. A 60 amino acid segment of zuotin has similarity to several histone H1 sequences. Disruption of ZUO1 in yeast resulted in a slow growth phenotype.

  2. Functional Characterization of Four Putative δ1-Pyrroline-5-Carboxylate Reductases from Bacillus subtilis

    Directory of Open Access Journals (Sweden)

    Giuseppe Forlani

    2017-08-01

    Full Text Available In most living organisms, the amino acid proline is synthesized starting from both glutamate and ornithine. In prokaryotes, in the absence of an ornithine cyclodeaminase that has been identified to date only in a small number of soil and plant bacteria, these pathways share the last step, the reduction of δ1-pyrroline-5-carboxylate (P5C catalyzed by P5C reductase (EC 1.5.1.2. In several species, multiple forms of P5C reductase have been reported, possibly reflecting the dual function of proline. Aside from its common role as a building block of proteins, proline is indeed also involved in the cellular response to osmotic and oxidative stress conditions. Genome analysis of Bacillus subtilis identifies the presence of four genes (ProH, ProI, ProG, and ComER that, based on bioinformatic and phylogenic studies, were defined as respectively coding a putative P5C reductase. Here we describe the cloning, heterologous expression, functional analysis and small-angle X-ray scattering studies of the four affinity-purified proteins. Results showed that two of them, namely ProI and ComER, lost their catalytic efficiency or underwent subfunctionalization. In the case of ComER, this could be likely explained by the loss of the ability to form a dimer, which has been previously shown to be an essential structural feature of the catalytically active P5C reductase. The properties of the two active enzymes are consistent with a constitutive role for ProG, and suggest that ProH expression may be beneficial to satisfy an increased need for proline.

  3. Functional Characterization of Four Putative d1-Pyrroline-5-Carboxylate Reductases from Bacillus subtilis

    Energy Technology Data Exchange (ETDEWEB)

    Forlani, Giuseppe; Nocek, Boguslaw; Chakravarthy, Srinivas; Joachimiak, Andrzej

    2017-08-02

    In most living organisms, the amino acid proline is synthesized starting from both glutamate and ornithine. In prokaryotes, in the absence of an ornithine cyclodeaminase that has been identified to date only in a small number of soil and plant bacteria, these pathways share the last step, the reduction of delta(1)-pyrroline-5-carboxylate (P5C) catalyzed by P5C reductase (EC 1.5.1.2). In several species, multiple forms of P5C reductase have been reported, possibly reflecting the dual function of proline. Aside from its common role as a building block of proteins, proline is indeed also involved in the cellular response to osmotic and oxidative stress conditions. Genome analysis of Bacillus subtilis identifies the presence of four genes (ProH, ProI, ProG, and ComER) that, based on bioinformatic and phylogenic studies, were defined as respectively coding a putative P5C reductase. Here we describe the cloning, heterologous expression, functional analysis and small-angle X-ray scattering studies of the four affinity-purified proteins. Results showed that two of them, namely ProI and ComER, lost their catalytic efficiency or underwent subfunctionalization. In the case of ComER, this could be likely explained by the loss of the ability to form a dimer, which has been previously shown to be an essential structural feature of the catalytically active P5C reductase. The properties of the two active enzymes are consistent with a constitutive role for ProG, and suggest that ProH expression may be beneficial to satisfy an increased need for proline.

  4. ExpR coordinates the expression of symbiotically important, bundle-forming Flp pili with quorum sensing in Sinorhizobium meliloti.

    Science.gov (United States)

    Zatakia, Hardik M; Nelson, Cassandra E; Syed, Umair J; Scharf, Birgit E

    2014-04-01

    Type IVb pili in enteropathogenic bacteria function as a host colonization factor by mediating tight adherence to host cells, but their role in bacterium-plant symbiosis is currently unknown. The genome of the symbiotic soil bacterium Sinorhizobium meliloti contains two clusters encoding proteins for type IVb pili of the Flp (fimbrial low-molecular-weight protein) subfamily. To establish the role of Flp pili in the symbiotic interaction of S. meliloti and its host, Medicago sativa, we deleted pilA1, which encodes the putative pilin subunit in the chromosomal flp-1 cluster and conducted competitive nodulation assays. The pilA1 deletion strain formed 27% fewer nodules than the wild type. Transmission electron microscopy revealed the presence of bundle-forming pili protruding from the polar and lateral region of S. meliloti wild-type cells. The putative pilus assembly ATPase CpaE1 fused to mCherry showed a predominantly unilateral localization. Transcriptional reporter gene assays demonstrated that expression of pilA1 peaks in early stationary phase and is repressed by the quorum-sensing regulator ExpR, which also controls production of exopolysaccharides and motility. Binding of acyl homoserine lactone-activated ExpR to the pilA1 promoter was confirmed with electrophoretic mobility shift assays. A 17-bp consensus sequence for ExpR binding was identified within the 28-bp protected region by DNase I footprinting analyses. Our results show that Flp pili are important for efficient symbiosis of S. meliloti with its plant host. The temporal inverse regulation of exopolysaccharides and pili by ExpR enables S. meliloti to achieve a coordinated expression of cellular processes during early stages of host interaction.

  5. Barcode Payment System in Trusted Mobile Devices

    OpenAIRE

    Vibha Kaw Raina

    2012-01-01

    Mobile payment is an application of mobile commerce which facilitates mobile commerce transactions by providing the mobile customer with a convenient means to pay. Many mobile payment methods have been proposed and implemented like user friendly, customer centric, merchant centric where security concerns are highly addressed. This paper proposes a mobile payment model with barcodes for mobile users to improve mobile user experience in mobile payment. Unlike other existing mobile payment syste...

  6. Mobility Network and Safety

    Directory of Open Access Journals (Sweden)

    Adriana Galderisi

    2010-04-01

    Full Text Available Mobility network is crucial for ensuring territorial safety with respect to natural and technological hazards. They represent a basic support to community’s everyday life although being exposed elements often characterized by high vulnerability to different hazards and, in the meanwhile, strategic equipments for emergency management. Physical damages or the lack in functioning of those networks may greatly increase the loss of human lives caused by hazardous events as well as produce relevant economic damages at medium and long term. Although the relevance of the mobility networks in assuring territorial safety is at present largely recognized, risk analyses have been long focused on buildings’ vulnerability or, even where they have paid attention to mobility network, they have been mainly focused on the physical damages that a given hazard could may induce on individual elements of such network. It is recent the awareness that mobility network represents a system, characterized by relevant interdependences both among its elements and among network infrastructures and urban systems. Based on these assumptions, this paper points out the heterogeneous aspects of the mobility network vulnerability and their relevance in increasing the overall territorial or urban vulnerability to hazardous events. Therefore, an in-depth investigation of the concept of mobility network vulnerability is provided, in order to highlight the aspects mostly investigated and more recent research perspectives. Finally, a case study in the Campania Region is presented in order to point out how traditional risk analyses, generally referred to individual hazards, can sometimes led to invest in the mobility network improvement or development which, targeted to increase the security of a territory result, on the opposite, in an increase of the territorial vulnerability.

  7. Phylogenetic and comparative gene expression analysis of barley (Hordeum vulgare)WRKY transcription factor family reveals putatively retained functions betweenmonocots and dicots

    Energy Technology Data Exchange (ETDEWEB)

    Mangelsen, Elke; Kilian, Joachim; Berendzen, Kenneth W.; Kolukisaoglu, Uner; Harter, Klaus; Jansson, Christer; Wanke, Dierk

    2008-02-01

    WRKY proteins belong to the WRKY-GCM1 superfamily of zinc finger transcription factors that have been subject to a large plant-specific diversification. For the cereal crop barley (Hordeum vulgare), three different WRKY proteins have been characterized so far, as regulators in sucrose signaling, in pathogen defense, and in response to cold and drought, respectively. However, their phylogenetic relationship remained unresolved. In this study, we used the available sequence information to identify a minimum number of 45 barley WRKY transcription factor (HvWRKY) genes. According to their structural features the HvWRKY factors were classified into the previously defined polyphyletic WRKY subgroups 1 to 3. Furthermore, we could assign putative orthologs of the HvWRKY proteins in Arabidopsis and rice. While in most cases clades of orthologous proteins were formed within each group or subgroup, other clades were composed of paralogous proteins for the grasses and Arabidopsis only, which is indicative of specific gene radiation events. To gain insight into their putative functions, we examined expression profiles of WRKY genes from publicly available microarray data resources and found group specific expression patterns. While putative orthologs of the HvWRKY transcription factors have been inferred from phylogenetic sequence analysis, we performed a comparative expression analysis of WRKY genes in Arabidopsis and barley. Indeed, highly correlative expression profiles were found between some of the putative orthologs. HvWRKY genes have not only undergone radiation in monocot or dicot species, but exhibit evolutionary traits specific to grasses. HvWRKY proteins exhibited not only sequence similarities between orthologs with Arabidopsis, but also relatedness in their expression patterns. This correlative expression is indicative for a putative conserved function of related WRKY proteins in mono- and dicot species.

  8. Phylogenetic and comparative gene expression analysis of barley (Hordeum vulgare WRKY transcription factor family reveals putatively retained functions between monocots and dicots

    Directory of Open Access Journals (Sweden)

    Jansson Christer

    2008-04-01

    Full Text Available Abstract Background WRKY proteins belong to the WRKY-GCM1 superfamily of zinc finger transcription factors that have been subject to a large plant-specific diversification. For the cereal crop barley (Hordeum vulgare, three different WRKY proteins have been characterized so far as regulators in sucrose signaling, pathogen defense, and in response to cold and drought. However, their phylogenetic relationship remained unresolved. Results In this study, we used available sequence information to identify a minimum number of 45 barley WRKY transcription factor (HvWRKY genes. According to their structural features, the HvWRKY factors were classified into the previously defined polyphyletic WRKY subgroups 1 to 3. Furthermore, we could assign putative orthologs of the HvWRKY proteins in Arabidopsis and rice. While in most cases clades of orthologous proteins were formed within each group or subgroup, other clades were composed of paralogous proteins for the grasses and Arabidopsis only, which is indicative of specific gene radiation events. To gain insight into their putative functions, we examined expression profiles of WRKY genes from publicly available microarray data resources and found group specific expression patterns. While putative orthologs of the HvWRKY transcription factors have been inferred from phylogenetic sequence analysis, we performed a comparative expression analysis of WRKY genes in Arabidopsis and barley. Indeed, highly correlative expression profiles were found between some of the putative orthologs. Conclusion HvWRKY genes have not only undergone radiation in monocot or dicot species, but exhibit evolutionary traits specific to grasses. HvWRKY proteins exhibited not only sequence similarities between orthologs with Arabidopsis, but also relatedness in their expression patterns. This correlative expression is indicative for a putative conserved function of related WRKY proteins in monocot and dicot species.

  9. Spacecraft (Mobile Satellite) configuration design study

    Science.gov (United States)

    1985-01-01

    The relative costs to procure and operate a two-satellite mobile satellite system designed to operate either in the UHF band of the L Band, and with several antenna diameter options in each frequency band was investigated. As configured, the size of the spacecraft is limited to the current RCA Series 4000 Geosynchronous Communications Spacecraft bus, which spans the range from 4000 to 5800 pounds in the transfer orbit. The Series 4000 bus forms the basis around which the Mobile Satellite transponder and associated antennas were appended. Although the resultant configuration has little outward resemblance to the present Series 4000 microwave communications spacecraft, the structure, attitude control, thermal, power, and command and control subsystems of the Series 4000 spacecraft are all adapted to support the Mobile Satellite mission.

  10. Uncovering the spatial structure of mobility networks

    CERN Document Server

    Louail, Thomas; Picornell, Miguel; Cantú, Oliva García; Herranz, Ricardo; Frias-Martinez, Enrique; Ramasco, José J; Barthelemy, Marc

    2015-01-01

    The extraction of a clear and simple footprint of the structure of large, weighted and directed networks is a general problem that has many applications. An important example is given by origin-destination matrices which contain the complete information on commuting flows, but are difficult to analyze and compare. We propose here a versatile method which extracts a coarse-grained signature of mobility networks, under the form of a $2\\times 2$ matrix that separates the flows into four categories. We apply this method to origin-destination matrices extracted from mobile phone data recorded in thirty-one Spanish cities. We show that these cities essentially differ by their proportion of two types of flows: integrated (between residential and employment hotspots) and random flows, whose importance increases with city size. Finally the method allows to determine categories of networks, and in the mobility case to classify cities according to their commuting structure.

  11. MobilED: a mobile tools and services platform for formal and informal learning

    CSIR Research Space (South Africa)

    Ford, M

    2009-03-01

    Full Text Available MobilED is a South African initiative aimed at designing teaching and learning environments that are meaningfully enhanced with mobile technologies and services. The deliverables are the development of a set of scenarios and guidelines on how mobile...

  12. Densified waste form and method for forming

    Science.gov (United States)

    Garino, Terry J.; Nenoff, Tina M.; Sava Gallis, Dorina Florentina

    2015-08-25

    Materials and methods of making densified waste forms for temperature sensitive waste material, such as nuclear waste, formed with low temperature processing using metallic powder that forms the matrix that encapsulates the temperature sensitive waste material. The densified waste form includes a temperature sensitive waste material in a physically densified matrix, the matrix is a compacted metallic powder. The method for forming the densified waste form includes mixing a metallic powder and a temperature sensitive waste material to form a waste form precursor. The waste form precursor is compacted with sufficient pressure to densify the waste precursor and encapsulate the temperature sensitive waste material in a physically densified matrix.

  13. Structure of protease-cleaved Escherichia coli α-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment

    Energy Technology Data Exchange (ETDEWEB)

    Fyfe, Cameron D.; Grinter, Rhys; Josts, Inokentijs; Mosbahi, Khedidja [University of Glasgow, Glasgow G12 8QQ, Scotland (United Kingdom); Roszak, Aleksander W. [University of Glasgow, Glasgow G12 8QQ, Scotland (United Kingdom); University of Glasgow, Glasgow G12 8QQ, Scotland (United Kingdom); Cogdell, Richard J.; Wall, Daniel M.; Burchmore, Richard J. S.; Byron, Olwyn; Walker, Daniel, E-mail: daniel.walker@glasgow.ac.uk [University of Glasgow, Glasgow G12 8QQ, Scotland (United Kingdom)

    2015-06-30

    The X-ray structure of protease-cleaved E. coli α-2-macroglobulin is described, which reveals a putative mechanism of activation and conformational change essential for protease inhibition. Bacterial α-2-macroglobulins have been suggested to function in defence as broad-spectrum inhibitors of host proteases that breach the outer membrane. Here, the X-ray structure of protease-cleaved Escherichia coli α-2-macroglobulin is described, which reveals a putative mechanism of activation and conformational change essential for protease inhibition. In this competitive mechanism, protease cleavage of the bait-region domain results in the untethering of an intrinsically disordered region of this domain which disrupts native interdomain interactions that maintain E. coli α-2-macroglobulin in the inactivated form. The resulting global conformational change results in entrapment of the protease and activation of the thioester bond that covalently links to the attacking protease. Owing to the similarity in structure and domain architecture of Escherichia coli α-2-macroglobulin and human α-2-macroglobulin, this protease-activation mechanism is likely to operate across the diverse members of this group.

  14. Characterization of putative class II bacteriocins identified from a non-bacteriocin-producing strain Lactobacillus casei ATCC 334.

    Science.gov (United States)

    Kuo, Yang-Cheng; Liu, Cheng-Feng; Lin, Jhao-Fen; Li, An-Chieh; Lo, Ta-Chun; Lin, Thy-Hou

    2013-01-01

    Several putative class II bacteriocin-like genes were identified in Lactobacillus casei ATCC 334, all of which might encode peptides with a double-glycine leader. Six peptides encoded by these genes were heterologously expressed in Escherichia coli and then partially purified in order to test their bacteriocin activity. The results revealed that the mature LSEI_2163 peptide was a class IId bacteriocin that exhibited antimicrobial activity against some lactobacilli and several Listeria species. Similarly, mature LSEI_2386 was a putative pheromone peptide that also had significant bacteriocin activity against several Listeria species. The activities of both peptides tolerated 121°C for 30 min but not treatment with proteinase K or trypsin. The two Cys residues located at positions 4 and 24 in the mature LSEI_2163 peptide were shown by mass spectrometry to form a disulfide bridge, which was required for optimal antibacterial activity. However, replacement of one or both Cys with Ser would cause significant reduction of the antibacterial activity, the reduction being greater when only one of the Cys residues (C4S) was replaced than when both (C4S/C24S) were replaced.

  15. Isolation of a putative receptor for KDEL-tailed cysteine proteinase (SH-EP) from cotyledons of Vigna mungo seedlings.

    Science.gov (United States)

    Tsuru-Furuno, A; Okamoto, T; Minamikawa, T

    2001-10-01

    SH-EP is the major papain-type proteinase expressed in cotyledons of germinated Vigna mungo seeds. The proteinase possesses a KDEL sequence at the C-terminus although the mature form of SH-EP is localized in vacuoles. It has also been shown that the proform of SH-EP is accumulated at the edge or middle region of the endoplasmic reticulum, and the accumulated proSH-EP is directly transported to vacuoles via the KDEL-tailed cysteine proteinase-accumulating vesicle, KV. In this study, to address the transport machinery of proSH-EP through KV, putative receptor for proSH-EP was isolated from membrane proteins of cotyledons of V. mungo seedlings using a proSH-EP-immobilized column. The deduced amino acid sequence from cDNA to the protein revealed that the putative receptor for proSH-EP is a member of vacuolar sorting receptor, VSR, that is known to be localized in the Golgi-complex and/or clathrin coated vesicle. We carried out subcellular fractionation of cotyledon cells and subsequently conducted SDS-PAGE/immunoblotting and immunocytochemistry with anti-V. mungo VSR (VmVSR) or SH-EP antibody. The results showed that VmVSR is co-localized in the fraction of the gradient in which KV existed.

  16. Early embryonic expression of a putative ecdysteroid-phosphate phosphatase in the water flea, Daphnia magna (Cladocera: Daphniidae).

    Science.gov (United States)

    Asada, Miki; Kato, Yasuhiko; Matsuura, Tomoaki; Watanabe, Hajime

    2014-01-01

    Ecdysteroids, known as molting hormones, play central roles in the onset of molting, metamorphosis, and reproduction in arthropods. The ecdysteroids stored in eggs also play an important role in embryogenesis. In insects, ecdysteroids are stored as phosphate esters, which are converted to an active form by ecdysteroid-phosphate phosphatase (EPPase). Although EPPase is believed to be widely conserved in the Ecdysozoa, little is known about its expression in clades other than Insecta. In this study, we cloned a putative EPPase gene from a small fresh water crustacean known as a water flea, Daphnia magna Straus (Cladocera: Daphniidae), and examined its expression during embryogenesis. The amino acid sequence of the putative crustacean EPPase cDNA showed high similarity to insect EPPase and human suppressor of T-cell receptor signaling-1. We also found that the D. magna EPPase was highly expressed during early embryogenesis; its expression rapidly decreased 6 h after oviposition. This timing corresponds to the onset of organogenesis in D. magna. The expression of EPPase could not be detected in diapaused eggs. This is the first report of an EPPase from crustaceans, and the results suggest that the function of EPPase is conserved between insects and crustaceans. © The Author 2014. Published by Oxford University Press on behalf of the Entomological Society of America.

  17. The putative Leishmania telomerase RNA (LeishTER undergoes trans-splicing and contains a conserved template sequence.

    Directory of Open Access Journals (Sweden)

    Elton J R Vasconcelos

    Full Text Available Telomerase RNAs (TERs are highly divergent between species, varying in size and sequence composition. Here, we identify a candidate for the telomerase RNA component of Leishmania genus, which includes species that cause leishmaniasis, a neglected tropical disease. Merging a thorough computational screening combined with RNA-seq evidence, we mapped a non-coding RNA gene localized in a syntenic locus on chromosome 25 of five Leishmania species that shares partial synteny with both Trypanosoma brucei TER locus and a putative TER candidate-containing locus of Crithidia fasciculata. Using target-driven molecular biology approaches, we detected a ∼2,100 nt transcript (LeishTER that contains a 5' spliced leader (SL cap, a putative 3' polyA tail and a predicted C/D box snoRNA domain. LeishTER is expressed at similar levels in the logarithmic and stationary growth phases of promastigote forms. A 5'SL capped LeishTER co-immunoprecipitated and co-localized with the telomerase protein component (TERT in a cell cycle-dependent manner. Prediction of its secondary structure strongly suggests the existence of a bona fide single-stranded template sequence and a conserved C[U/C]GUCA motif-containing helix II, representing the template boundary element. This study paves the way for further investigations on the biogenesis of parasite TERT ribonucleoproteins (RNPs and its role in parasite telomere biology.

  18. Application of a Colorimetric Assay to Identify Putative Ribofuranosylaminobenzene 5'-Phosphate Synthase Genes Expressed with Activity in Escherichia coli

    Directory of Open Access Journals (Sweden)

    Bechard Matthew E.

    2003-01-01

    Full Text Available Tetrahydromethanopterin (H4MPT is a tetrahydrofolate analog originally discovered in methanogenic archaea, but later found in other archaea and bacteria. The extent to which H4MPT occurs among living organisms is unknown. The key enzyme which distinguishes the biosynthetic pathways of H4MPT and tetrahydrofolate is ribofuranosylaminobenzene 5'-phosphate synthase (RFAP synthase. Given the importance of RFAP synthase in H4MPT biosynthesis, the identification of putative RFAP synthase genes and measurement of RFAP synthase activity would provide an indication of the presence of H4MPT in untested microorganisms. Investigation of putative archaeal RFAP synthase genes has been hampered by the tendency of the resulting proteins to form inactive inclusion bodies in Escherichia coli. The current work describes a colorimetric assay for measuring RFAP synthase activity, and two modified procedures for expressing recombinant RFAP synthase genes to produce soluble, active enzyme. By lowering the incubation temperature during expression, RFAP synthase from Archaeoglobus fulgidus was produced in E. coli and purified to homogeneity. The production of active RFAP synthase from Methanothermobacter thermautotrophicus was achieved by coexpression of the gene MTH0830 with a molecular chaperone. This is the first direct biochemical identification of a methanogen gene that codes for an active RFAP synthase.

  19. Efficient Mobility Management Signalling in Network Mobility Supported PMIPV6.

    Science.gov (United States)

    Samuelraj, Ananthi Jebaseeli; Jayapal, Sundararajan

    2015-01-01

    Proxy Mobile IPV6 (PMIPV6) is a network based mobility management protocol which supports node's mobility without the contribution from the respective mobile node. PMIPV6 is initially designed to support individual node mobility and it should be enhanced to support mobile network movement. NEMO-BSP is an existing protocol to support network mobility (NEMO) in PMIPV6 network. Due to the underlying differences in basic protocols, NEMO-BSP cannot be directly applied to PMIPV6 network. Mobility management signaling and data structures used for individual node's mobility should be modified to support group nodes' mobility management efficiently. Though a lot of research work is in progress to implement mobile network movement in PMIPV6, it is not yet standardized and each suffers with different shortcomings. This research work proposes modifications in NEMO-BSP and PMIPV6 to achieve NEMO support in PMIPV6. It mainly concentrates on optimizing the number and size of mobility signaling exchanged while mobile network or mobile network node changes its access point.

  20. Efficient Mobility Management Signalling in Network Mobility Supported PMIPV6

    Directory of Open Access Journals (Sweden)

    Ananthi Jebaseeli Samuelraj

    2015-01-01

    Full Text Available Proxy Mobile IPV6 (PMIPV6 is a network based mobility management protocol which supports node’s mobility without the contribution from the respective mobile node. PMIPV6 is initially designed to support individual node mobility and it should be enhanced to support mobile network movement. NEMO-BSP is an existing protocol to support network mobility (NEMO in PMIPV6 network. Due to the underlying differences in basic protocols, NEMO-BSP cannot be directly applied to PMIPV6 network. Mobility management signaling and data structures used for individual node’s mobility should be modified to support group nodes’ mobility management efficiently. Though a lot of research work is in progress to implement mobile network movement in PMIPV6, it is not yet standardized and each suffers with different shortcomings. This research work proposes modifications in NEMO-BSP and PMIPV6 to achieve NEMO support in PMIPV6. It mainly concentrates on optimizing the number and size of mobility signaling exchanged while mobile network or mobile network node changes its access point.

  1. mobility of children with myelomeningocele

    Directory of Open Access Journals (Sweden)

    Agata Korzeniecka-Kozerska

    2016-02-01

    Full Text Available Background. Myelomenigocele (MMC is the most severe form of spina bifida, caused by genetic and environmental components; it has many serious complications in a patient’s future life, where dysfunctional mobility is one of the most troublesome. Objectives. The aim of our study was to explore the role of selected factors: parental and perinatal in children with myelomenigocele and correlate them with their future motor function. Material and methods. This retrospective analysis was based on 95 births that occurred from 1985 to 2013. Clinical data were collected using medical records and supplemented by a questionnaire for parents. Standard deviation of WHO scores (Z-scores for weight, length, and body mass index (BMI at birth were calculated. Hoffer’s scale was used to assess MMC children’s motor function. Results . There were no statistically significant differences between 53 girls and 42 boys who were enrolled in the study, excluding the month of conception. The tested parameters did not vary substantially according to maternal age. Maternal age correlated positively with paternal age at conception, birth order, and stillbirth rate. Mode of delivery was strongly associated with Apgar scale and birth weight. Apgar score, birth length, and thus WHO Z-score for length-for-age had positive correlations with future mobility of MMC children. Conclusions . 1. Perinatal factors have a significant effect on children’s physical activity. 2. There is no clinical evidence that cesarean section improves early neurological outcome of MMC infants. 3. Parental factors, particularly maternal age, do not determine the future mobility of children with myelomeningocele.

  2. Tropomyosin-1, A Putative Tumor-Suppressor and a Biomarker of Human Breast Cancer

    Science.gov (United States)

    2004-10-01

    cDNA. Lobular carcinoma - 2 A polyclonal pan-TM antibody that recognizes multiple TM Phyllodes tumor - 1 Not determined from the initial pathology...AD Award Number: DAMD17-98-1-8162 TITLE: Tropomyosin-1, A Putative Tumor -Suppressor and a Biomarker of Human Breast Cancer PRINCIPAL INVESTIGATOR...4. TITLE AND SUBTITLE 5. FUNDING NUMBERS Tropomyosin-l, A Putative Tumor -Suppressor and a Biomarker DAMD17-98-1-8162 of Human Breast Cancer 6. A UTHOR

  3. Fluoroquinolone-Resistant Haemophilus parasuis Isolates Exhibit More Putative Virulence Factors than Their Susceptible Counterparts

    OpenAIRE

    Zhang, Qiang; Liu, Jiantao; Yan, Shuxian; Yang, Yujie; Zhang, Anding; Jin, Meilin

    2013-01-01

    The prevalence of 23 putative virulence factors among fluoroquinolone-susceptible and -resistant Haemophilus parasuis isolates was analyzed. Putative hemolysin precursor, fimbrial assembly chaperone, and type I site-specific restriction modification system R subunit genes were more prevalent among fluoroquinolone-resistant H. parasuis isolates than among fluoroquinolone-susceptible H. parasuis isolates. Fluoroquinolone resistance may be associated with an increase in the presence of some viru...

  4. Structural Encoding of Static Single Assignment Form

    DEFF Research Database (Denmark)

    Gal, Andreas; Probst, Christian; Franz, Michael

    2005-01-01

    Static Single Assignment (SSA) form is often used as an intermediate representation during code optimization in Java Virtual Machines. Recently, SSA has successfully been used for bytecode verification. However, constructing SSA at the code consumer is costly. SSAbased mobile code transport formats...

  5. [Mobility and balance].

    Science.gov (United States)

    Schmitt, Katrin; Kressig, Reto W

    2008-08-01

    Quality of life is strongly associated with the mobility of elderly people. Falls often cause restricted mobility, a decline in activities of daily living and an increased risk of institutionalisation. Frailty, commonly associated with aging, is a biologic syndrome of decreased resistance to stressors, resulting from declines across multiple physiological systems. Changes in mobility and gait constitute part of the frailty syndrome. Since more than one third of persons over the age of 65 fall each year, prevention of falls is very important. Already while taking the patients' history special emphasis should be laid on matters associated with an increased risk of falling, such as the use of more than four medications. To assess mobility several brief tests exist (i.e. Timed up & go [17], Walking while Talking [20]) which immediately yield information regarding mobility and falling risk. Patients with poor performance on such tests or those with a history of several falls should undergo a spatio-temporal gait analysis in order to determine a possible cause as well as suitable interventions. Additionally, the objective measurement of temporo-spatial gait parameters under dual task conditions may detect deficits in cognitive function. Several interventions have been shown to have favourable effects on gait stability and the occurrence of falls. Proprioceptive problems can be partially compensated for by wearing special shoes. Also, different movement exercises such as Tai Chi Chuan, Jaques-Dalcroze eurhythmics and social dancing are associated with better balance and gait safety, and a reduction of falls.

  6. Mobile Marketing Applications of Travel Agencies

    Directory of Open Access Journals (Sweden)

    Murat Selim Selvi

    2014-11-01

    Full Text Available In recent years, the use of mobile devices in the marketing world is increasing parallel with technological advances. The main problem of this research is to determine agencies’ use of what type of mobile tools for what type of purposes in the marketing process. The aim of this research is to identify Mobile Marketing (MM applications used by group A travel agencies, and to describe the attitudes towards MM applications of agencies. According to related law, it is only group A agencies give all agency services. Therefore, it is thought that MM is more widely used by those agencies. Thus, this research was made only on the group A agencies. The population of study was consisted of 675 groups A agencies’ representatives deployed in the European and Asian sides of Istanbul. A questionnaire was used as data collection tool. Questionnaire form consisted of two parts. In the first part, questions concerning MM and in the second part, questions regarding demographic issues to managers and travel agents took place. The results were given as descriptive statistics (frequencies, percentages, mean and standard deviation on the tables. T-test and One Way ANOVA analysis were performed for the differences of mean among groups. In the study it was concluded that agencies use mobile phones mostly and mobile computers for increasing sales firstly and direct marketing. Thus, the main hypothesis established was confirmed partly.

  7. Mobile Marketing Applications of Travel Agencies

    Directory of Open Access Journals (Sweden)

    Murat Selim Selvi

    2016-01-01

    Full Text Available In recent years, the use of mobile devices in the marketing world is increasing parallel with technological advances. The main problem of this research is to determine agencies’ use of what type of mobile tools for what type of purposes in the marketing process. The aim of this research is to identify Mobile Marketing (MM applications used by group A travel agencies, and to describe the attitudes towards MM applications of agencies. According to related law, it is only group A agencies give all agency services. Therefore, it is thought that MM is more widely used by those agencies. Thus, this research was made only on the group A agencies. The population of study was consisted of 675 groups A agencies’ representatives deployed in the European and Asian sides of Istanbul. A questionnaire was used as data collection tool. Questionnaire form consisted of two parts. In the first part, questions concerning MM and in the second part, questions regarding demographic issues to managers and travel agents took place. The results were given as descriptive statistics (frequencies, percentages, mean and standard deviation on the tables. T-test and One Way ANOVA analysis were performed for the differences of mean among groups. In the study it was concluded that agencies use mobile phones mostly and mobile computers for increasing sales firstly and direct marketing. Thus, the main hypothesis established was confirmed partly.

  8. Comparative Evaluation of Mobile Forensic Tools

    Directory of Open Access Journals (Sweden)

    Oluwafemi Osho

    2016-01-01

    Full Text Available Mobile technology, over the years, has improved tremendously in sophistication and functionality. Today, there are mobile phones, known as smartphones, that can perform virtually most functions associated with personal computers. This has translated to increase in the adoption of mobile technology. Consequently, there has been an increase in the number of attacks against and with the aid of this technology. Mobile phones will often contain data that are needed as evidence in a court of law. And, therefore, the need to be able to acquire and present this data in an admissible form cannot be overemphasized. This requires the right forensic tools. This is the focus of this study. We evaluated the ability of four forensic tools to extract data, with emphasis on deleted data, from Android phones. Our results show that AccessData FTK Imager and EnCase performed better than MOBILedit Forensic and Oxygen Forensic Suite at acquiring deleted data. The conclusion is that, finding a forensic tool or toolkit that is virtually applicable across all mobile device platforms and operating systems is currently infeasible.

  9. Prevalence and characteristics of Streptococcus pneumoniae "putative serotype 6E" isolates from Asian countries.

    Science.gov (United States)

    Baek, Jin Yang; Park, In Ho; So, Thomas Man-kit; Lalitha, M K; Shimono, Nobuyuki; Yasin, Rohani Md; Carlos, Celia C; Perera, Jennifer; Thamlikitkul, Visanu; Hsueh, Po-Ren; Van, Pham Hung; Shibl, Atef M; Song, Jae-Hoon; Ko, Kwan Soo

    2014-12-01

    The prevalence, antimicrobial susceptibility, and genotypes of Streptococcus pneumoniae “putative serotype 6E” isolates from Asian countries were investigated. A total of 244 S. pneumoniae serogroup 6 isolates obtained from 11 Asian countries were included in this study. Of the 244 serogroup 6 isolates, 101 (41.4%) were typed as "putative serotype 6E," followed by serotypes 6A, 6B, 6C, and 6D (27.0, 20.1, 5.7, and 5.7%, respectively). Multilocus sequence typing revealed that clonal complex (CC) 90, including ST90 and its variants, was the most prevalent clonal group of "putative serotype 6E" isolates (n = 63; 62.4%). CC146 and CC315 were also found frequently in some of the countries. Most of the "putative serotype 6E" isolates showed very high resistance rates against cefuroxime, erythromycin, azithromycin, clarithromycin, clindamycin, and trimethoprim/sulfamethoxazole, probably due to their highly resistant to antimicrobials clone, CC90. Our results indicate that “putative serotype 6E” is prevalent in Asian countries. The clonal dissemination of "putative serotype 6E" isolates was also identified.

  10. Characterization of putative effectors from the cereal cyst nematode Heterodera avenae.

    Science.gov (United States)

    Cui, Jiangkuan; Peng, Huan; Qiao, Fen; Wang, Gaofeng; Huang, Wenkun; Wu, Duqign; Peng, Deliang

    2017-09-20

    Few molecular details of effectors of Heterodera avenae parasitism are known. We performed a high-throughput sequencing analysis of the H. avenae transcriptome at five developmental stages. A total of 82,549 unigenes were ultimately obtained, and 747 transcripts showed best hits to genes putatively encoding carbohydrate-active enzymes in plant parasitic nematodes that play an important role in the invasion process. A total of 1480 unigenes were homologous to known phytonematode effectors, and 63 putative novel effectors were identified in the H. avenae transcriptomes. Twenty-three unigenes were analyzed by qRT-PCR and confirmed to be highly expressed during at least one developmental stage. For in situ hybridization, 17 of the 22 tested putative effectors were specifically expressed and located in the subventral gland cells, and five putative novel effectors were specifically expressed in the dorsal gland. Furthermore, 115 transcripts were found to have putative lethal RNA interference (RNAi) phenotypes. Three target genes with lethal RNAi phenotypes and two of the four tested putative effectors were associated with a decrease in the number of cysts through in vitro RNAi technology. These transcriptomic data lay a foundation for further studies of interactions of H. avenae with cereal and H. avenae parasitic control.

  11. Total Synthesis of Putative 11-epi-Lyngbouilloside Aglycon

    Science.gov (United States)

    Kolleth, Amandine; Gebauer, Julian; ElMarrouni, Abdelatif; Lebeuf, Raphael; Prévost, Céline; Brohan, Eric; Arseniyadis, Stellios; Cossy, Janine

    2016-01-01

    We report here the total synthesis of 11-epi-lyngbouilloside aglycon. Our strategy features a Boeckman-type esterification followed by a RCM to form the 14-membered ring macrolactone and a late-stage side chain introduction via a Wittig olefination. Overall, the final product was obtained in 20 steps and 2% overall yield starting from commercially available 3-methyl-but-3-enol. Most importantly, the strategy employed is versatile enough to eventually allow us to complete the synthesis of the natural product and irrevocably confirm its structure. PMID:27556024

  12. Cosmopolitanism through mobility: physical-corporeal or virtual-imagined?

    Science.gov (United States)

    Petzold, Knut

    2017-04-01

    In the context of increasing cross-border mobility and the associated interconnections and diversities, 'cosmopolitanism' has become a key concept in sociology. Understood as individual real-world orientation, many authors consider a central cause for cosmopolitanism in physical-corporeal mobility, in particular transnationally. However, the significance of virtual and imagined mobility, such as via television or the Internet, is increasingly emphasized. Nevertheless, it has so far been little examined how and with which relative strength physical-corporeal and virtual-imagined mobility are associated with cosmopolitan orientations. Unlike previous studies, the two forms of mobility are considered simultaneously. On the basis of existing studies and theoretical considerations, it is assumed that the dimension of global orientation is influenced rather by physical-corporeal than by virtual-imagined mobility, whereas the dimension of cultural openness is influenced rather by virtual-imagined than by physical mobility. One reason could be the different potential of the mobility forms to respond to perceived conflicts in the confrontation with the Other. The hypotheses are preliminary tested using data from an online survey that allows both to distinguish locals, (national) shuttles and transnationals, and to query media use. An exploratory principal component analysis confirmed, as in other studies, that global orientation and cultural openness are distinct dimensions. The results of the multivariate analyses largely support the hypotheses and indicate that in investigations of cosmopolitanism, the processes of identity-related self-categorization should be distinguished from pure socialization processes.

  13. Molecular mobility in glassy dispersions

    Science.gov (United States)

    Mehta, Mehak; McKenna, Gregory B.; Suryanarayanan, Raj

    2016-05-01

    Dielectric spectroscopy was used to characterize the structural relaxation in pharmaceutical dispersions containing nifedipine (NIF) and either poly(vinyl) pyrrolidone (PVP) or hydroxypropyl methylcellulose acetate succinate (HPMCAS). The shape of the dielectric response (permittivity versus log time) curve was observed to be independent of temperature. Thus, for the pure NIF as well as the dispersions, the validity of the time-temperature superposition principle was established. Furthermore, though the shape of the full dielectric response varied with polymer concentration, the regime related to the α- or structural relaxation was found to superimpose for the dispersions, though not with the response of the NIF itself. Hence, there is a limited time-temperature-concentration superposition for these systems as well. Therefore, in this polymer concentration range, calculation of long relaxation times in these glass-forming systems becomes possible. We found that strong drug-polymer hydrogen bonding interactions improved the physical stability (i.e., delayed crystallization) by reducing the molecular mobility. The strength of hydrogen bonding, structural relaxation time, and crystallization followed the order: NIF-PV P>NIF-HPMCAS>NIF. With an increase in polymer concentration, the relaxation times were longer indicating a decrease in molecular mobility. The temperature dependence of relaxation time, in other words fragility, was independent of polymer concentration. This is the first application of the superposition principle to characterize structural relaxation in glassy pharmaceutical dispersions.

  14. Molecular mobility in glassy dispersions

    Energy Technology Data Exchange (ETDEWEB)

    Mehta, Mehak [Univ. of Minnesota, Minneapolis, MN (United States). Dept. of Pharmaceutics; McKenna, Gregory B. [Texas Tech Univ., Lubbock, TX (United States). Dept. of Chemical Engineering; Suryanarayanan, Raj [Univ. of Minnesota, Minneapolis, MN (United States). Dept. of Pharmaceutics

    2016-05-27

    Dielectric spectroscopy was used to characterize the structural relaxation in pharmaceutical dispersions containing nifedipine (NIF) and either poly(vinyl) pyrrolidone (PVP) or hydroxypropyl methylcellulose acetate succinate (HPMCAS). The shape of the dielectric response (permittivity versus log time) curve was observed to be independent of temperature. Thus, for the pure NIF as well as the dispersions, the validity of the time-temperature superposition principle was established. Furthermore, though the shape of the full dielectric response varied with polymer concentration, the regime related to the α- or structural relaxation was found to superimpose for the dispersions, though not with the response of the NIF itself. Hence, there is a limited time-temperature-concentration superposition for these systems as well. Therefore, in this polymer concentration range, calculation of long relaxation times in these glass-forming systems becomes possible. We found that strong drug-polymer hydrogen bonding interactions improved the physical stability (i.e., delayed crystallization) by reducing the molecular mobility. The strength of hydrogen bonding, structural relaxation time, and crystallization followed the order: NIF$-$PV P>NIF$-$HPMCAS>NIF. With an increase in polymer concentration, the relaxation times were longer indicating a decrease in molecular mobility. The temperature dependence of relaxation time, in other words fragility, was independent of polymer concentration. This is the first application of the superposition principle to characterize structural relaxation in glassy pharmaceutical dispersions.

  15. Intensities of Mobility

    DEFF Research Database (Denmark)

    Bissell, David; Vannini, Phillip; Jensen, Ole B.

    2016-01-01

    This paper explores the intensities of long-distance commuting journeys in order to understand how bodily sensibilities become attuned to the regular mobilities which they undertake. More people are travelling farther to and from work than ever before, owing to a variety of factors which relate...... to complex social and geographical dynamics of transport, housing, lifestyle, and employment. Yet, the experiential dimensions of long-distance commuting have not received the attention that they deserve within research on mobilities. Drawing from fieldwork conducted in Australia, Canada, and Denmark...... this paper aims to further develop our collective understanding of the experiential particulars of long-distance workers or ‘supercommuters’. Rather than focusing on the extensive dimensions of mobilities that are implicated in broad social patterns and trends, our paper turns to the intensive dimensions...

  16. Supplier Resource Mobilization

    DEFF Research Database (Denmark)

    Ellegaard, Chris; Kragh, Hanne; Andersen, Poul Houman

    Companies that wish to draw benefit from supplier resources beyond standard market offerings must actively make an effort to mobilize these resources. This task has been a major topic of interest in the management literature, but the continued reported problems of companies attempting to influence...... suppliers suggests that the knowledge of this challenge is yet inadequate. The purpose of this paper is therefore to establish a research agenda on supplier resource mobilization that can improve this knowledge. To fulfill the purpose we review the management literature and identify the most prevalent...... theoretical perspectives. This review, synthesis, and resultant discussion allow us to propose that future research should look closer at the resource activation process on the supplier side, the role of the buyer-supplier relationship in resource mobilization, and the approach of the buying company...

  17. Graphene mobility mapping

    DEFF Research Database (Denmark)

    Buron, Jonas Christian Due; Pizzocchero, Filippo; Jepsen, Peter Uhd

    2015-01-01

    Carrier mobility and chemical doping level are essential figures of merit for graphene, and large-scale characterization of these properties and their uniformity is a prerequisite for commercialization of graphene for electronics and electrodes. However, existing mapping techniques cannot directly...... assess these vital parameters in a non-destructive way. By deconvoluting carrier mobility and density from non-contact terahertz spectroscopic measurements of conductance in graphene samples with terahertz-transparent backgates, we are able to present maps of the spatial variation of both quantities over...... graphene indicates dominance by charged scatterers. Unexpectedly, significant variations in mobility rather than doping are the cause of large conductance inhomogeneities, highlighting the importance of statistical approaches when assessing large-area graphene transport properties....

  18. Mobile Probing and Probes

    DEFF Research Database (Denmark)

    2013-01-01

    Mobile probing is a method, developed for learning about digital work situations, as an approach to discover new grounds. The method can be used when there is a need to know more about users and their work with certain tasks, but where users at the same time are distributed (in time and space......). Mobile probing was inspired by the cultural probe method, and was influenced by qualitative interview and inquiry approaches. The method has been used in two subsequent projects, involving school children (young adults at 15-17 years old) and employees (adults) in a consultancy company. Findings point...... to mobile probing being a flexible method for uncovering the unknowns, as a way of getting rich data to the analysis and design phases. On the other hand it is difficult to engage users to give in depth explanations, which seem easier in synchronous dialogs (whether online or face2face). The development...

  19. Mobile Probing and Probes

    DEFF Research Database (Denmark)

    2012-01-01

    Mobile probing is a method, which has been developed for learning about digital work situations, as an approach to discover new grounds. The method can be used when there is a need to know more about users and their work with certain tasks, but where users at the same time are distributed (in time...... and space). Mobile probing was inspired by the cultural probe method, and was influenced by qualitative interview and inquiry approaches. The method has been used in two subsequent projects, involving school children (young adults at 15-17 years old) and employees (adults) in a consultancy company. Findings...... point to mobile probing being a flexible method for uncovering the unknowns, as a way of getting rich data to the analysis and design phases. On the other hand it is difficult to engage users to give in depth explanations, which seem easier in synchronous dialogs (whether online or face2face...

  20. Sensing interrail mobility

    DEFF Research Database (Denmark)

    Jensen, Martin Trandberg

    Tourism encapsulates human experiences driven by desires, affective urges and sensuous dispositions. This dissertation is a hymn to the embodied and affective experiences of one particular mode of tourism mobility, interrail. I suggest that mobility means much more than functional movement between...... A and B. Rather, mobility is explored as a socio-material, embodied and non-representational experience set in the mundanity of ordinary train travel. While such everyday experience may appear banal as we come across them they are in no ways trivial. By adopting and developing innovative and multimodal...... materialities. Consequently, this doctoral work wrestles with questions pertaining to the ontologies, epistemologies and methodologies of tourism research, and extends and contributes to post-structural movements in tourism studies. Martin Trandberg Jensen is part of the Tourism Research Unit at the Department...