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Sample records for pulse emp survey

  1. Electromagnetic pulse (EMP) survey of the FEMA Region X Federal Regional Center, Bothell, Washington

    Energy Technology Data Exchange (ETDEWEB)

    Crutcher, R.I.; Buchanan, M.E.; Jones, R.W.

    1991-11-01

    The purpose of this report is to develop an engineering design package to protect the Federal Emergency Management Agency (FEMA) National Radio System (FNARS) facilities against the effects of high-altitude electromagnetic pulses (HEMPS). This report refers to the FEMA Federal Regional Center (FRC) in Bothell, Washington. It is highly probably that there will be a heavy dependence upon high-frequency (hf) radio communications for long-haul communications following a nuclear attack on the continental United States, should one occur. To maintain the viability of the FEMA hf radio network during such a situation, the FNARS facilities must take measures to protect against the effects of HEMP that are likely to be created in a nuclear confrontation. The equipment under stress has already been designed and built so that little opportunity exists for equipment design changes that could raise the threshold levels at which malfunctions occur. The solution must then be to reduce HEMP-induced stresses on the system by means of tailored retrofit hardening measures using commercial protection devices when available. If is the intent of this report to define the particular hardening measures that will minimize the susceptibility of the network components to HEMP effects. To the extent economically viable, protective actions have been recommended for implementation, along with necessary changes or additions, during the period of the FNARS upgrade program. This report addresses electromagnetic pulse (EMP) effects only, and disregards any condition in which radiation effects may be a factor. This report identifies the systems in the facility considered critical for emergency option. To identify the critical systems in the facility and the EMP coupling paths into these systems, an EMP survey of the facility was conducted. Results of the survey are presented along with recommendations for tailored retrofit hardening measures to be implemented to protect the facility from EMP.

  2. Protection of Medical Equipment against Electromagnetic Pulse (EMP): phase I

    Science.gov (United States)

    1986-06-12

    characteriitic associated with a typical EMP pin threat. This pin threat can be s ecified either as a damped sine wave or a rectangular pulse having a short ...Spectrophotometer, Stasar ............................... 77 7.12 Opthalmic Diathermy , TR 3000 ........................... 80 7.13 Birtcher 771 Micro...Opthalmic Diathermy TR 3000 ............................................. 82 7.12b Opthalmic Diathermy TR 3000 ................................... 83 7.13

  3. Analysis of electromagnetic pulse (EMP measurements in the National Ignition Facility's target bay and chamber

    Directory of Open Access Journals (Sweden)

    Brown C.G.

    2013-11-01

    Full Text Available From May 2009 to the present we have recorded electromagnetic pulse (EMP strength and spectrum (100 MHz – 5 GHz in the target bay and chamber of the National Ignition Facility (NIF. The dependence of EMP strength and frequency spectrum on target type and laser energy is discussed. The largest EMP measured was for relatively low-energy, short-pulse (100 ps flat targets.

  4. The cause of outliers in electromagnetic pulse (EMP) locations

    Energy Technology Data Exchange (ETDEWEB)

    Fenimore, Edward E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-10-02

    We present methods to calculate the location of EMP pulses when observed by 5 or more satellites. Simulations show that, even with a good initial guess and fitting a location to all of the data, there are sometime outlier results whose locations are much worse than most cases. By comparing simulations using different ionospheric transfer functions (ITFs), it appears that the outliers are caused by not including the additional path length due to refraction rather than being caused by not including higher order terms in the Appleton-Hartree equation. We suggest ways that the outliers can be corrected. These correction methods require one to use an electron density profile along the line of sight from the event to the satellite rather than using the total electron content (TEC) to characterize the ionosphere.

  5. Mitigation of Electromagnetic Pulse (EMP) Effects from Short-Pulse Lasers and Fusion Neutrons

    Energy Technology Data Exchange (ETDEWEB)

    Eder, D C; Throop, A; Brown, Jr., C G; Kimbrough, J; Stowell, M L; White, D A; Song, P; Back, N; MacPhee, A; Chen, H; DeHope, W; Ping, Y; Maddox, B; Lister, J; Pratt, G; Ma, T; Tsui, Y; Perkins, M; O' Brien, D; Patel, P

    2009-03-06

    Our research focused on obtaining a fundamental understanding of the source and properties of EMP at the Titan PW(petawatt)-class laser facility. The project was motivated by data loss and damage to components due to EMP, which can limit diagnostic techniques that can be used reliably at short-pulse PW-class laser facilities. Our measurements of the electromagnetic fields, using a variety of probes, provide information on the strength, time duration, and frequency dependence of the EMP. We measure electric field strengths in the 100's of kV/m range, durations up to 100 ns, and very broad frequency response extending out to 5 GHz and possibly beyond. This information is being used to design shielding to mitigate the effects of EMP on components at various laser facilities. We showed the need for well-shielded cables and oscilloscopes to obtain high quality data. Significant work was invested in data analysis techniques to process this data. This work is now being transferred to data analysis procedures for the EMP diagnostics being fielded on the National Ignition Facility (NIF). In addition to electromagnetic field measurements, we measured the spatial and energy distribution of electrons escaping from targets. This information is used as input into the 3D electromagnetic code, EMSolve, which calculates time dependent electromagnetic fields. The simulation results compare reasonably well with data for both the strength and broad frequency bandwidth of the EMP. This modeling work required significant improvements in EMSolve to model the fields in the Titan chamber generated by electrons escaping the target. During dedicated Titan shots, we studied the effects of varying laser energy, target size, and pulse duration on EMP properties. We also studied the effect of surrounding the target with a thick conducting sphere and cube as a potential mitigation approach. System generated EMP (SGEMP) in coaxial cables does not appear to be a significant at Titan. Our

  6. Electromagnetic pulse (EMP): Exposure of missile 56 in EMP simulator sapiens

    Science.gov (United States)

    Dikvall, T.

    1985-06-01

    The effects on the electric field caused by the object (missile) in the SAPIENS electromagnetic pulse simulator were studied. A noticeable effect on the field strength is noted close to the object, due to the characteristics of the field. This effect also appears in real electromagnetic pulse environments. During these tests 200 pulses were distributed with good accuracy of reproduction. The SAPIENS is an outdoor device and tests carried out in winter show that weather has very little influence on results.

  7. Did high-altitude EMP (electromagnetic pulse) cause the Hawaiian streetlight incident

    Energy Technology Data Exchange (ETDEWEB)

    Vittitoe, C N

    1989-04-01

    Studies of electromagnetic pulse (EMP) effects on civilian and military systems predict results ranging from severe destruction to no damage. Convincing analyses that support either extreme are rare. The Hawaiian streetlight incident associated with the Starfish nuclear burst is the most widely quoted observed damage. We review the streetlight characteristics and estimate the coupling between the Starfish EMP and a particular streetlight circuit identified as one of the few that failed. Evidence indicates that the damage was EMP-generated. The main contributing factors were the azimuthal angle of the circuit relative to the direction of EMP propagation, and the rapid rise of the EMP signal. The azimuthal angle provided coherent buildup of voltage as the EMP swept across the transmission line. The rapid rise allowed substantial excitation before the canceling effects of ground reflections limited the signals. Resulting voltages were at the threshold for causing the observed fuse damage and are consistent with this damage occurring in only some of the strings in the systems. 15 refs., 16 figs., 4 tabs.

  8. Electromagnetic Pulse Sensor and Simulation Notes - EMP 1-27

    Science.gov (United States)

    1980-05-01

    22zo 0 v a (5) Y r. where. r 2 x + z2 The constant V is defined by normalizing the o 0 0 voltage between the plates to unity: i.e. V rA E(x,z...cones. Again, normalizing each 3ource to 1 volt, one obtains a magnetic aource for the upper cone as Jk -(r(x a/4)2 + Z2 ) M e [(X - a/4) 2 + z2 ( 0 0...2 dx’ (50) 48 V EMP 1-27 245-45 The comments regarding the solution of (36) in section 2 are also applicable to the solucion of (50). d. Time

  9. Development of Design Information Template for Nuclear Power Plants for Electromagnetic Pulse (EMP) Effect Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Minyi; Ryu, Hosan; Ye, Songhae; Lee, Euijong [KNHP CRI, Daejeon (Korea, Republic of)

    2016-10-15

    An electromagnetic pulse (EMP) is a transient electromagnetic shock wave that has powerful electric and magnetic fields that can destroy electronic equipment. It is generally well-known that EMPs can cause the malfunction and disorder of electronic equipment and serious damages to electric power systems and communication networks. Research is being carried out to protect nuclear power plants (NPPs) from EMP threats. Penetration routes of EMPs can be roughly categorized into two groups, radioactivity and conductivity. The radioactive effect refers to an impact transmitted to the ground from high-altitude electromagnetic pulses (HEMP). Such an impact may affect target equipment through the point of entry (POE) of the concrete structure of an NPP. The conductive effect refers to induced voltage or current coupled to the NPPs cable structure. The induced voltage and current affect the target equipment via connected cables. All these factors must be considered when taking into account EMP effect analysis for NPPs. To examine all factors, it is necessary to fully understand the schemes of NPPs. This paper presents a four type design information template that can be used to analyze the EMP effect in operating nuclear power plants. In order to analyze of the effects of EMPs on operating NPPs, we must consider both the conductive and radioactive effects on the target (system, equipment, structure). For these reasons, not only the equipment information, but also the information about the structure and the external penetration will be required. We are developing a design information template for robust nuclear design information acquisition. We expect to develop a block diagram on the basis of the template.

  10. Minimizing the Effects of Electromagnetic Pulse (EMP) on Field Medical Equipment

    Science.gov (United States)

    1991-06-07

    Keep wiring short . Unplug unused equipment, Run power cabling and tents in a magnetic North-South direction. Avoid running power cabling in the East...electromagnetic pulse (EMP) is a radiated electromagnetic (EM) wave caused by the detonation of a nuclear weapcn above the earth’s atmosphere. A one megaton...Analyzer Endoscopic Light Source Ophthalmic Diathermy Flame Photometer These wudies demons rated that selected items of otherwise unprotected medical

  11. The Establishment of Object Selection Criteria for Effect Analysis of Electromagnetic Pulse (EMP) in Operating Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Ye, Song Hae; Ryu, Hosun; Kim, Minyi; Lee, Euijong [KHNP CRI, Daejeon (Korea, Republic of)

    2016-10-15

    The electromagnetic pulse (EMP) can be used as a strategic weapon by inducing damaging voltage and currents that the electrical circuits are not designed to withstand. EMPs are lethal to electronic systems. All EMP events have three common components: a source, coupling path, and receptor. It can also travel across power grids, destroying electronics as it passes in less than a second. There have been no research studies on the effect analysis for EMP in domestic nuclear power plants and power grids. To ensure the safety of operating nuclear power plants in this environment, the emission of EMP is needed for the effect analysis and safety measures against EMPs. Actually, it is difficult and inefficient to conduct the effect analysis of EMP with all the equipment and systems in nuclear power plants (NPPs). Therefore, this paper presents the results of establishing the object selection criteria for the effect analysis of EMP in operating nuclear power plants through reviewing previous research in the US and the safety related design concepts in domestic NPPs. It is not necessary to ensure the continued operation of the plant in intense multiple EMP environments. The most probable effect of EMP on a modern nuclear power plant is an unscheduled shutdown. EMP may also cause an extended shutdown by the unnecessary activation of some safety related systems. In general, EMP can be considered a nuisance to nuclear plants, but it is not considered a serious threat to plant safety. The results of EMP effect analysis show less possibility of failure in the tested individual equipment. It was also confirmed that there is no possibility of simultaneous failure for devices in charge of the safety shutdown in the NPP.

  12. High Voltage Pulse Testing Survey.

    Science.gov (United States)

    1985-10-01

    Cryogenic 23 E. Liquids 26 F. Solids 28 1. Polyethylene 28 2. Cross-Linked Polyethylene ( XLPE ) 29 3. Polyimide and Polyvenylchloride (PVC) 31 VI Benefits 35 A...Strength of XLPE Cables 29 vii * 4" I PROGRAM OBJECTIVES The Pulse Test Survey summarizes government, industry, and technical reports on high voltage pulse...system of silicone oil on a XLPE (cross-linked polyethylene) spacer tends to lower the impulse breakdown by approximately 10 percent. The negative impulse

  13. EMP coupling to ships

    Energy Technology Data Exchange (ETDEWEB)

    Deadrick, F.J.; Cabayan, H.S.; Kunz, K.F.; Bevensee, R.M.; Martin, L.C.; Egbert, R.W.

    1980-01-01

    Scale-model tests were conducted to establish the adequacy and limitations of model measurements as tools for predicting electromagnetic pulse (EMP) coupling voltages and currents to the critical antennas, cables, and metallic structures on ships. The scale-model predictions are compared with the results of the full-scale EMP simulation test of the Canadian ASW ship, HMCS Huron. (The EMP coupling predictions in this report were made without prior knowledge of the results of the data from the HMCS Huron tests.) This report establishes that the scale-model tests in conjunction with the data base from EMP coupling modules provides the necessary information for source model development and permits effective, low-cost study of particular system configurations. 184 figures, 9 tables.

  14. A Nuclear Electromagnetic Pulse (EMP) Vulnerability/Lethality (V/L) Taxonomy With Focus on Component Assessment.

    Science.gov (United States)

    1994-11-01

    Martin 1983) and upset/burnout experiments were performed (Tasca, Peden, and Miletta 1972, Kalab 1981; Thomas and Diloreto 1985; Wenaas and Fromme ...Also, conservation of total current is assumed S÷J-P ). In PNJUNCTION , the previous equations are num erically im plem ented through the Yee Finite...Wenaas, E. P., and D. A. Fromme . "Electronics Malfunction Levels and Related EMP Hardening Approaches for Aircraft." DNA001-84-C-0295, Jaycor, San Diego

  15. New SETI Sky Surveys for Radio Pulses

    CERN Document Server

    Siemion, Andrew; McMahon, Peter; Korpela, Eric; Werthimer, Dan; Anderson, David; Bower, Geoff; Cobb, Jeff; Foster, Griffin; Lebofsky, Matt; van Leeuwen, Joeri; Mallard, William; Wagner, Mark

    2008-01-01

    Berkeley conducts 7 SETI programs at IR, visible and radio wavelengths. Here we review two of the newest efforts, Astropulse and Fly's Eye. A variety of possible sources of microsecond to millisecond radio pulses have been suggested in the last several decades, among them such exotic events as evaporating primordial black holes, hyper-flares from neutron stars, emissions from cosmic strings or perhaps extraterrestrial civilizations, but to-date few searches have been conducted capable of detecting them. We are carrying out two searches in hopes of finding and characterizing these uS to mS time scale dispersed radio pulses. These two observing programs are orthogonal in search space; the Allen Telescope Array's (ATA) "Fly's Eye" experiment observes a 100 square degree field by pointing each 6m ATA antenna in a different direction; by contrast, the Astropulse sky survey at Arecibo is extremely sensitive but has 1/3,000 of the instantaneous sky coverage. Astropulse's multibeam data is transferred via the interne...

  16. Meterwavelength Single-pulse Polarimetric Emission Survey

    CERN Document Server

    Mitra, Dipanjan; Maciesiak, Krzysztof; Skrzypczak, Anna; Melikidze, George I; Szary, Andrzej; Krzeszowski, Krzysztof

    2016-01-01

    We have conducted the Meterwavelength Single-pulse Polarimetric Emission Survey to study the radio emission properties of normal pulsars. A total of 123 pulsars with periods between 0.1 seconds and 8.5 seconds were observed in the survey at two different frequencies, 105 profiles at 333 MHz, 118 profiles at 618 MHz and 100 pulsars at both. In this work we concentrate primarily on the time-averaged properties of the pulsar emission. The measured widths of the pulsar profiles in our sample usually exhibit the radius to frequency mapping. We validate the existence of lower bounds for the distribution of profile widths with pulsar period ($P$), which is seen for multiple definitions of the width, viz. a lower boundary line (LBL) at $2.7^{\\circ} P^{-0.5}$ with width measured at 50% level of profile peak, a LBL at $5.7^{\\circ} P^{-0.5}$ for 10% level of peak and LBL at $6.3^{\\circ} P^{-0.5}$ for width defined as 5$\\sigma$ above the baseline level. In addition we have measured the degree of linear polarization in th...

  17. Lightning driven EMP in the upper atmosphere

    Science.gov (United States)

    Rowland, H. L.; Fernsler, R. F.; Huba, J. D.; Bernhardt, P. A.

    1995-01-01

    Large lightning discharges can drive electromagnetic pulses (EMP) that cause breakdown of the neutral atmosphere between 80 and 95 km leading to order of magnitude increases in the plasma density. The increase in the plasma density leads to increased reflection and absorption, and limits the pulse strength that propagates higher into the ionosphere.

  18. The Effects of Corona on Current Surges Induced on Conducting Lines by EMP (Electromagnetic Pulse): A Comparison of Experiment Data with Results of Analytic Corona Models

    Science.gov (United States)

    1987-09-01

    265-281. 18. Rogers , S.R., and R.A. Perala, "The Effects of Corona and Angle of Arrival on the EMP Response of Cables Lying on the Surface of the...Survivability Organization, Boeing Aerospace COmpany, P. 0. Box 399, Seattle, WA 98124 74. V. L. Chartier , Bonneville Power Administration, P. 0. Box

  19. Interim Report of the Defense Science Board (DSB) Task Force on the Survivability of Systems and Assets to Electromagnetic Pulse (EMP) and other Nuclear Weapon Effects (NWE)

    Science.gov (United States)

    2011-08-01

    major platforms for High Altitude EMP ( HEMP ) protection, and the Navy implemented a requirements review process. United States Strategic Command...Army improving process for independent review of survivability – Air Force committing resources for testing major platforms for HEMP protection...battlespaces where nuclear weapons are threatening or are being employed. The most likely case(s) are use of nuclear weapons by others. Although

  20. EMP-002a Phase Shift through the Ionosphere

    Energy Technology Data Exchange (ETDEWEB)

    Soltz, R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Simons, D. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Fenimore, E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Wilks, S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Carey, T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-10-20

    In this note we review the derivation and use of the Ionospheric Transfer Function (ITF) in the DIO- RAMA model to calculate the propagation of a broad band ElectroMagnetic Pulse (EMP) through the Ionosphere in the limit of geometric optics. This note is intended to resolve a misunderstanding between the NDS VVA and EMP modeling teams regarding the appropriate use of the phase and group velocities in DIORAMA. The di erent approaches are documented in EMP-002 note, \\Phase vs. Group" [1], generated by the LLNL DIORAMA VVA team, and the subsequent response from the DIORAMA EMP modeling team' [2].

  1. Plasma radome designed for the EMP effects defense

    Science.gov (United States)

    Li, Zhigang; Wang, Jiachun; Cheng, Li; Wang, Qichao

    2016-11-01

    Radar, as the main detection means, plays an extremely important role in modern warfare. However, it is easily attacked by the electromagnetic pulse (EMP) weapon. In order to defense the threat, a radome formed by plasma is designed. The plasma radome is used to protect the radar systems against EMP coupling through both `front door' and `back door'. What's more, the damage effects of EMP to the radar systems are analyzed, and the protection mechanism of plasma to EMP weapon is discussed. In addition, a simulation experiment is carried out to verify the feasibility of the plasma radome to defense against EMP. The results indicate that the structure performs well, which makes it a new method against EMP weapon.

  2. EMP/GMD Phase 0 Report, A Review of EMP Hazard Environments and Impacts

    Energy Technology Data Exchange (ETDEWEB)

    Rivera, Michael Kelly [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Backhaus, Scott N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Woodroffe, Jesse Richard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Henderson, Michael Gerard [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Bos, Randall J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Nelson, Eric Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kelic, Andjelka [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-11-01

    The purpose of this study is to determine methods to analyze the hazard environments, impacts, and consequences of different sources of electromagnetic pulse (EMP), including nuclear electromagnetic pulse (NEMP) and geomagnetic disturbance (GMD) on the U.S. electric power infrastructures and to use those methods to determine EMP and GMD events of concern. The study will be carried out in four phases, each of which will provide higher levels of analytic fidelity that focuses on those EMP/GMD sources and events that create significant consequences, or whose consequences are sufficiently uncertain, to require more in-depth study. This study will leverage the best experimental data; device, equipment and system models; and simulation tools currently available. This study focuses primarily on the bulk electric system (BES) including large generating stations, large power transformers, the transmission network, and transmission system protection. Electrical distribution systems may potentially be included, if warranted, after consideration of the consequences for the bulk power system.

  3. Changing pattern of the subcellular distribution of erythroblast macrophage protein (Emp) during macrophage differentiation.

    Science.gov (United States)

    Soni, Shivani; Bala, Shashi; Kumar, Ajay; Hanspal, Manjit

    2007-01-01

    Erythroblast macrophage protein (Emp) mediates the attachment of erythroid cells to macrophages and is required for normal differentiation of both cell lineages. In erythroid cells, Emp is believed to be involved in nuclear extrusion, however, its role in macrophage differentiation is unknown. Information on the changes in the expression level and subcellular distribution of Emp in differentiating macrophages is essential for understanding the function of Emp. Macrophages of varying maturity were examined by immunofluorescence microscopy and biochemical methods. Our data show that Emp is expressed in all stages of maturation, but its localization pattern changes dramatically during maturation: in immature macrophages, a substantial fraction of Emp is associated with the nuclear matrix, whereas in more mature cells, Emp is expressed largely at cell surface. Pulse-chase experiments show that nascent Emp migrates intracellularly from the cytoplasm to the plasma membrane more efficiently in mature macrophages than in immature cells. Incubation of erythroid cells with macrophages in culture shows that erythroid cells attach to mature macrophages but not to immature macrophage precursors. Together, our data show that the temporal and spatial expression of Emp correlates with its role in erythroblastic island formation and suggest that Emp may be involved in multiple cellular functions.

  4. Survey of pork, poultry, coffee, beer and pulses for ochratoxin A

    DEFF Research Database (Denmark)

    Jørgensen, Kevin

    1998-01-01

    Surveys have been carried out to estimate the levels of ochratoxin A in pork, poultry, coffee, beer and pulses.. A total of 286 samples were analysed The results show that compared with cereals and cereal products the contribution from the foods surveyed to the total intake of ochratoxin A by the......Surveys have been carried out to estimate the levels of ochratoxin A in pork, poultry, coffee, beer and pulses.. A total of 286 samples were analysed The results show that compared with cereals and cereal products the contribution from the foods surveyed to the total intake of ochratoxin...

  5. EMP INDUCES APOPTOSIS IN HUMAN LUNG CARCINOMA CELL LINE GLC-82

    Institute of Scientific and Technical Information of China (English)

    曹晓哲; 赵梅兰; 王德文; 董波

    2002-01-01

    Objective: To study the effect of electromagnetic pulse (EMP) on apoptosis of human lung carcinoma cell line GLC-82. Methods: The injury changes in GLC-82 cells after irradiated by EMP (electric field intensity was 60 kV/m with 5 pulses/2 min) were analyzed by cytometry, MTT chronometry and flow cytometry. The immuno- histochemical SP staining was used to determine the expressions of bcl-2 protein and p53 protein. The stained positive cells were analyzed by CMIAS-II image analysis system at a magnification 400. All data were analyzed by SPSS8.0 software. Results: EMP could obviously inhibited lung carcinoma cell line GLC-82 proliferation and increased the number of non-adherent cells. The absorbance value (A570) of MTT decreased immediately, at 0 h, 1 h and 6 h after the GLC-82 cells irradiated by EMP as compared with control group. The highest apoptosis rate was found to reach 13.38% by flow cytometry at 6 h after EMP irradiation. Down-regulation of bcl-2 expression and up-regulation of bax expression were induced by EMP. Conclusion: EMP promoted apoptosis of GLC-82 cells. At same time, EMP can down-regulate bcl-2 expression and up-regulate p53 expression in GLC-82 cells. The bcl-2 and the p53 protein may involve the apoptotic process.

  6. A Low Frequency Survey of Giant Pulses from the Crab Pulsar

    CERN Document Server

    Eftekhari, T; Dowell, J; Schinzel, F K; Taylor, G B

    2016-01-01

    We present a large survey of giant pulses from the Crab Pulsar as observed with the first station of the Long Wavelength Array. Automated methods for detecting giant pulses at low frequencies where scattering becomes prevalent are also explored. More than 1400 pulses were detected across four frequency bands between 20 - 84 MHz over a seven month period beginning in 2013, with additional followup observations in late 2014 and early 2015. A handful of these pulses were detected simultaneously across all four frequency bands. We examine pulse characteristics, including pulse broadening and power law indices for amplitude distributions. We find that the flux density increases toward shorter wavelengths, consistent with a spectral turnover at 100 MHz. Our observations uniquely span multiple scattering epochs, manifesting as a notable trend in the number of detections per observation. These results are characteristic of the variable interface between the synchrotron nebula and the surrounding interstellar medium.

  7. Survey of pork, poultry, coffee, beer and pulses for ochratoxin A

    DEFF Research Database (Denmark)

    Jørgensen, Kevin

    1998-01-01

    Surveys have been carried out to estimate the levels of ochratoxin A in pork, poultry, coffee, beer and pulses.. A total of 286 samples were analysed The results show that compared with cereals and cereal products the contribution from the foods surveyed to the total intake of ochratoxin...... A by the Danish population must be considered to be of less importance....

  8. Methods for Free-Space Ultra-Short Solitary EMP Measurement

    Directory of Open Access Journals (Sweden)

    Eva Kadlecova

    2006-01-01

    Full Text Available There are some suitable methods for ultra-short solitary electromagnetic pulses (EMP measurement. The EMPs are generated by high power microwave generators. The characteristic of EMPs is high power level (Pmax = 250 MW and very short time duration (tp Î ns. Special requirements for measurement methods are placed because of the specific EMPs properties.Two suitable methods for this application are presented in the paper. The first – calorimetric method, utilizes the thermal impacts of microwave absorption. The second method presented – magneto-optic method, use the Faraday’s magneto-optic effect as a sensor principle. It was realized combined calorimetric sensor and there were made some experimental EMP measurements with good results. The sensor utilizing magneto-optic method is in development.

  9. EMP response modeling of TVS based on the recurrent neural network

    Directory of Open Access Journals (Sweden)

    Zhiqiang JI

    2015-04-01

    Full Text Available Due to the larger workload in the implementation process and the poor consistence between the test results and actual situation problems when using the transmission line pulse (TLP testing methods, a modeling method based on the recurrent neural network is proposed for EMP response forecast. Based on the TLP testing system, two categories of EMP are increased, which are the machine model ESD EMP and human metal model ESD EMP. Elman neural network, Jordan neural network and their combination namely Elman-Jordan neural network are established for response modeling of NUP2105L transient voltage suppressor (TVS forecasting the response under different EMP. The simulation results show that the recurrent neural network has satisfying modeling effects and high computation efficiency.

  10. The High Time Resolution Universe Survey - III. Single-pulse searches and preliminary analysis

    CERN Document Server

    Burke-Spolaor, S; Johnston, S; Bates, S D; Bhat, N D R; Burgay, M; D'Amico, N; Jameson, A; Keith, M J; Kramer, M; Levin, L; Milia, S; Possenti, A; Stappers, B; van Straten, W

    2011-01-01

    We present the search methods and initial results for transient radio signals in the High Time Resolution Universe (HTRU) Survey. The HTRU survey's single-pulse search, the software designed to perform the search, and a determination of the HTRU survey's sensitivity to single pulses are described. Initial processing of a small fraction of the survey has produced 11 discoveries, all of which are sparsely-emitting neutron stars, as well as provided confirmation of two previously unconfirmed neutron stars. Most of the newly discovered objects lie in regions surveyed previously, indicating both the improved sensitivity of the HTRU survey observing system and the dynamic nature of the radio sky. The cycles of active and null states in nulling pulsars, rotating radio transients (RRATs), and long-term intermittent pulsars are explored in the context of determining the relationship between these populations, and of the sensitivity of a search to the various radio-intermittent neutron star populations. This analysis s...

  11. Analysis of a Van de Graaff Generator for EMP Direct Current Survivability Testing

    Science.gov (United States)

    2013-03-01

    13.82 (A) at a spark gap of 3″ to 354 ± 22.10 (A) for a spark gap of 8″. Using the settings explored in this thesis, the VDG has some value for use ...7 2.2 High Altitude Electromagnetic Pulse ( HEMP ) ................................................. 11 2.3 Dielectric Breakdown of Air...situation that results in High Altitude EMP ( HEMP ) [9]. .............. 11 Figure 7. The magnitude of EMP, lighting and electrostatic discharge [2

  12. Taking the Pulse of Undergraduate Health Psychology: A Nationwide Survey

    Science.gov (United States)

    Brack, Amy Badura; Kesitilwe, Kutlo; Ware, Mark E.

    2010-01-01

    We conducted a random national survey of 100 doctoral, 100 comprehensive, and 100 baccalaureate institutions to determine the current state of the undergraduate health psychology course. We found clear evidence of a maturing course with much greater commonality in name (health psychology), theoretical foundation (the biopsychosocial model), and…

  13. Endothelial microparticles (EMP) bind and activate monocytes: elevated EMP-monocyte conjugates in multiple sclerosis.

    Science.gov (United States)

    Jy, Wenche; Minagar, Alireza; Jimenez, Joaquin J; Sheremata, William A; Mauro, Lucia M; Horstman, Lawrence L; Bidot, Carlos; Ahn, Yeon S

    2004-09-01

    Elevated plasma endothelial microparticles (EMP) have been documented in MS during exacerbation. However, the role of EMP in pathogenesis of MS remains unclear. We investigated the formation of EMP-monocyte conjugates (EMP-MoC) and their potential role in transendothelial migration of inflammatory cells in MS. EMP-MoC were assayed in 30 MS patients in exacerbation, 20 in remission and in 35 controls. EMP-leukocyte conjugation was investigated flowcytometrically by employing alpha-CD54 or alpha-CD62E for EMP, and alpha-CD45 for leukocytes. EMP-MoC were characterized by identifying adhesion molecules involved and their effect on monocyte function. In vivo (clinical): EMP-MoC were markedly elevated in exacerbation vs. remission and controls, correlating with presence of GD+ MRI lesions. Free CD54+ EMP were not elevated but free CD62E+ EMP were. In vitro: EMP bound preferentially to monocytes, less to neutrophils, but little to lymphocytes. Bound EMP activated monocytes: CD11b expression increased 50% and migration through cerebral endothelial cell layer increased 2.6-fold. Blockade of CD54 reduced binding by 80%. Most CD54+ EMP bound to monocytes, leaving little free EMP, while CD62+ EMP were found both free and bound. These results demonstrated that phenotypic subsets of EMP interacted differently with monocytes. Based on our observations, EMP may enhance inflammation and increase transendothelial migration of monocytes in MS by binding to and activating monocytes through CD54. EMP-MoC were markedly increased in MS patients in exacerbation compared to remission and may serve as a sensitive marker of MS disease activity.

  14. Pulse

    Science.gov (United States)

    ... resting for at least 10 minutes. Take the exercise heart rate while you are exercising. ... pulse rate can help determine if the person's heart is pumping. Pulse ... rate gives information about your fitness level and health.

  15. Comparison of equilibrium ohmic and nonequilibrium swarm models for monitoring conduction electron evolution in high-altitude EMP calculations

    Science.gov (United States)

    Pusateri, Elise N.; Morris, Heidi E.; Nelson, Eric; Ji, Wei

    2016-10-01

    Atmospheric electromagnetic pulse (EMP) events are important physical phenomena that occur through both man-made and natural processes. Radiation-induced currents and voltages in EMP can couple with electrical systems, such as those found in satellites, and cause significant damage. Due to the disruptive nature of EMP, it is important to accurately predict EMP evolution and propagation with computational models. CHAP-LA (Compton High Altitude Pulse-Los Alamos) is a state-of-the-art EMP code that solves Maxwell's equations for gamma source-induced electromagnetic fields in the atmosphere. In EMP, low-energy, conduction electrons constitute a conduction current that limits the EMP by opposing the Compton current. CHAP-LA calculates the conduction current using an equilibrium ohmic model. The equilibrium model works well at low altitudes, where the electron energy equilibration time is short compared to the rise time or duration of the EMP. At high altitudes, the equilibration time increases beyond the EMP rise time and the predicted equilibrium ionization rate becomes very large. The ohmic model predicts an unphysically large production of conduction electrons which prematurely and abruptly shorts the EMP in the simulation code. An electron swarm model, which implicitly accounts for the time evolution of the conduction electron energy distribution, can be used to overcome the limitations exhibited by the equilibrium ohmic model. We have developed and validated an electron swarm model previously in Pusateri et al. (2015). Here we demonstrate EMP damping behavior caused by the ohmic model at high altitudes and show improvements on high-altitude, upward EMP modeling obtained by integrating a swarm model into CHAP-LA.

  16. Epson EMP-S1投影机的升级产品EMP-S1H

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    EMP-S1是Epson公司推出的1款颇具影响力的经济型投影机,2004年5月Epson推出了EMP-S1的升级产品EMP-S1H。EMP.S1H在原有EMP-S1投影机的基础上亮度提高到了1400流明,同时对比度也提高到500:1,对比度的提高使图像层次感更好,影像更富有质感。

  17. EMP-induced alterations of tight junction protein expression and disruption of the blood-brain barrier.

    Science.gov (United States)

    Ding, Gui-Rong; Qiu, Lian-Bo; Wang, Xiao-Wu; Li, Kang-Chu; Zhou, Yong-Chun; Zhou, Yan; Zhang, Jie; Zhou, Jia-Xing; Li, Yu-Rong; Guo, Guo-Zhen

    2010-07-15

    The blood-brain barrier (BBB) is critical to maintain cerebral homeostasis. In this study, we examined the effects of exposure to electromagnetic pulse (EMP) on the functional integrity of BBB and, on the localization and expression of tight junction (TJ) proteins (occludin and ZO-1) in rats. Animals were sham or whole-body exposed to EMP at 200 kV/m for 400 pulses. The permeability of BBB in rat cerebral cortex was examined by using Evans Blue (EB) and lanthanum nitrate as vascular tracers. The localization and expression of TJ proteins were assessed by western blot and immunofluorescence analysis, respectively. The data indicated that EMP exposure caused: (i) increased permeability of BBB, and (ii) altered localization as well as decreased levels of TJ protein ZO-1. These results suggested that the alteration of ZO-1 may play an important role in the disruption of tight junctions, which may lead to dysfunction of BBB after EMP exposure.

  18. [Endothelial microparticles (EMP) in physiology and pathology].

    Science.gov (United States)

    Sierko, Ewa; Sokół, Monika; Wojtukiewicz, Marek Z

    2015-08-18

    Endothelial microparticles (EMP) are released from endothelial cells (ECs) in the process of activation and/or apoptosis. They harbor adhesive molecules, enzymes, receptors and cytoplasmic structures and express a wide range of various constitutive antigens, typical for ECs, at their surface. Under physiological conditions the concentration of EMP in the blood is clinically insignificant. However, it was reported that under pathological conditions EMP concentration in the blood might slightly increase and contribute to blood coagulation, angiogenesis and inflammation. It has been shown that EMP directly and indirectly contribute to the activation of blood coagulation. Endothelial microparticles directly participate in blood coagulation through their surface tissue factor (TF) - a major initiator of blood coagulation. Furthermore, EMP exhibit procoagulant potential via expression of negatively charged phospholipids at their surface, which may promote assembly of coagulation enzymes (TF/VII, tenases and prothrombinase complexes), leading to thrombus formation. In addition, they provide a binding surface for coagulation factors: IXa, VIII, Va and IIa. Moreover, it is possible that EMP transfer TF from TF-bearing EMP to activated platelets and monocytes by binding them through adhesion molecules. Also, EMP express von Willebrand factor, which may facilitate platelet aggregation. Apart from their procoagulant properties, it was demonstrated that EMP may express adhesive molecules and metalloproteinases (MMP-2, MMP-9) at their surface and release growth factors, which may contribute to angiogenesis. Additionally, surface presence of C3 and C4 - components of the classical pathway - suggests pro-inflammatory properties of these structures. This article contains a summary of available data on the biology and pathophysiology of endothelial microparticles and their potential role in blood coagulation, angiogenesis and inflammation.

  19. Mechanisms involved in the blood-testis barrier increased permeability induced by EMP.

    Science.gov (United States)

    Wang, Xiao-Wu; Ding, Gui-Rong; Shi, Chang-Hong; Zeng, Li-Hua; Liu, Jun-Ye; Li, Jing; Zhao, Tao; Chen, Yong-Bin; Guo, Guo-Zhen

    2010-09-30

    The blood-testis barrier (BTB) plays an important role in male reproductive system. Lots of environmental stimulations can increase the permeability of BTB and then result in antisperm antibody (AsAb) generation, which is a key step in male immune infertility. Here we reported the results of male mice exposed to electromagnetic pulse (EMP) by measuring the expression of tight-junction-associated proteins (ZO-1 and Occludin), vimentin microfilaments, and transforming growth factor-beta (TGF-beta3) as well as AsAb level in serum. Male BALB/c mice were sham exposed or exposed to EMP at two different intensities (200kV/m and 400kV/m) for 200 pulses. The testes were collected at different time points after EMP exposure. Immunofluorescence histocytochemistry, western blotting, laser confocal microscopy and RT-PCR were used in this study. Compared with sham group, the expression of ZO-1 and TGF-beta3 significantly decreased accompanied with unevenly stained vimentin microfilaments and increased serum AsAb levels in EMP-exposed mice. These results suggest a potential BTB injury and immune infertility in male mice exposed to a certain intensity of EMP.

  20. observaciones empíricas

    Directory of Open Access Journals (Sweden)

    Beatriz González Vázquez

    2007-01-01

    Full Text Available En el desarrollo y éxito de los espacios innovadores las relaciones entre los agentes integrantes de los mismos resultan esenciales. En este artículo se analizan las redes de relaciones en varias áreas tecnológicas, con el objetivo de comprobar si existe un mismo modelo en todas ellas. La red en dichos espacios se estudia tanto desde una perspectiva reticular, apoyándose en los atributos de las empresas y en las variables relacionales extraídas de los flujos entre las mismas, como desde la búsqueda de un modelo cuantitativo explicativo. El análisis empírico se realiza en las redes de tres Parques Tecnológicos, y de los resultados se extrae que la morfología de la red está influenciada por la estrategia de crecimiento que haya mantenido la dirección del parque en función de las condiciones industriales de su área geográfica. El análisis cuantitativo confirma el modelo centro-periferia observado en las redes.

  1. Experiences with intercropping design - a survey about pulse cereal-combinations in Europe

    DEFF Research Database (Denmark)

    von Fragstein und Niemsdorff, P.; Knudsen, Marie Trydeman; Gooding, M.J.

    2008-01-01

    A survey was carried out within five European countries with regard to the practice of cereal grain legume intercropping. The mostly given combination was spring barleyspring pea beside 27 other combinations between pulses and cereals. 72 % of all examples consisted of spring varieties, the rest...... of winter varieties, mainly a special case of the French South West with mild winter climate. Intercrops were mainly used for feeding purposes. Best experiences were named as better yield stability, effective weed suppression, and good quality of feed. Of the negative experiences complicated mechanical weed...

  2. Assessment and mitigation of radiation, EMP, debris & shrapnel impacts at megajoule-class laser facilities

    Science.gov (United States)

    Eder, D. C.; Anderson, R. W.; Bailey, D. S.; Bell, P.; Benson, D. J.; Bertozzi, A. L.; Bittle, W.; Bradley, D.; Brown, C. G.; Clancy, T. J.; Chen, H.; Chevalier, J. M.; Combis, P.; Dauffy, L.; Debonnel, C. S.; Eckart, M. J.; Fisher, A. C.; Geille, A.; Glebov, V. Y.; Holder, J.; Jadaud, J. P.; Jones, O.; Kaiser, T. B.; Kalantar, D.; Khater, H.; Kimbrough, J.; Koniges, A. E.; Landen, O. L.; MacGowan, B. J.; Masters, N. D.; MacPhee, A.; Maddox, B. R.; Meyers, M.; Osher, S.; Prasad, R.; Raffestin, D.; Raimbourg, J.; Rekow, V.; Sangster, C.; Song, P.; Stoeckl, C.; Stowell, M. L.; Teran, J. M.; Throop, A.; Tommasini, R.; Vierne, J.; White, D.; Whitman, P.

    2010-08-01

    The generation of neutron/gamma radiation, electromagnetic pulses (EMP), debris and shrapnel at mega-Joule class laser facilities (NIF and LMJ) impacts experiments conducted at these facilities. The complex 3D numerical codes used to assess these impacts range from an established code that required minor modifications (MCNP - calculates neutron and gamma radiation levels in complex geometries), through a code that required significant modifications to treat new phenomena (EMSolve - calculates EMP from electrons escaping from laser targets), to a new code, ALE-AMR, that is being developed through a joint collaboration between LLNL, CEA, and UC (UCSD, UCLA, and LBL) for debris and shrapnel modelling.

  3. Modeling High Altitude EMP using a Non-Equilibrium Electron Swarm Model to Monitor Conduction Electron Evolution (LA-UR-15-26151)

    Science.gov (United States)

    Pusateri, E. N.; Morris, H. E.; Nelson, E.; Ji, W.

    2015-12-01

    Electromagnetic pulse (EMP) events in the atmosphere are important physical phenomena that occur through both man-made and natural processes, such as lightning, and can be disruptive to surrounding electrical systems. Due to the disruptive nature of EMP, it is important to accurately predict EMP evolution and propagation with computational models. In EMP, low-energy conduction electrons are produced from Compton electron or photoelectron ionizations with air. These conduction electrons continue to interact with the surrounding air and alter the EMP waveform. Many EMP simulation codes use an equilibrium ohmic model for computing the conduction current. The equilibrium model works well when the equilibration time is short compared to the rise time or duration of the EMP. However, at high altitude, the conduction electron equilibration time can be comparable to or longer than the rise time or duration of the EMP. This matters, for example, when calculating the EMP propagating upward toward a satellite. In these scenarios, the equilibrium ionization rate becomes very large for even a modest electric field. The ohmic model produces an unphysically large number of conduction electrons that prematurely and abruptly short the EMP in the simulation code. An electron swarm model, which simulates the time evolution of conduction electrons, can be used to overcome the limitations exhibited by the equilibrium ohmic model. We have developed and validated an electron swarm model in an environment characterized by electric field and pressure previously in Pusateri et al. (2015). This swarm model has been integrated into CHAP-LA, a state-of-the-art EMP code developed by researchers at Los Alamos National Laboratory, which previously calculated conduction current using an ohmic model. We demonstrate the EMP damping behavior caused by the ohmic model at high altitudes and show improvements on high altitude EMP modeling obtained by employing the swarm model.

  4. 爱普生EMP-TW2000

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    爱普生EMP-TW2000是爱普生家用投影机中规格最高的一款产品。它具有1600流明的高亮度,两组HDMI接口。EMP-TW2000采用爱普生最新研发的0.74英寸C2Fine技术的D6液晶面板,C2 FINE技术中独有的VA(垂直取向)模式,能大幅度地减少光泄漏,

  5. Role of Off-Line-of-Sight Propagation in Geomagnetic EMP Formation

    Energy Technology Data Exchange (ETDEWEB)

    Kruger, Hans W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-05-23

    The author’s synchrotron radiation based 3D geomagnetic EMP code MACSYNC has been used to explore the impact on pulse rise time and air conductivity of EMP propagation paths to the observer that are located off the direct line-of-sight (LOS) between gamma source and observer. This geometry is always present because, for an isotropic source, most the gammas are emitted at an angle with respect to the LOS. Computations for a 1 kt near-surface burst observed from space yield two principal findings: 1. The rise time is generated by the combined actions of a) electron spreading along the LOS due to the Compton electron emission angular distribution folded with electron multiple scattering effects, and b) radiation arrival time spreading due to length differences for different off-LOS propagation paths. The pulse rise time does not depend on the rise time of the conductivity. The conductivity rise time determines the pulse amplitude. 2. One-dimensional legacy EMP codes are inherently incapable of producing the correct pulse shape because they cannot treat the dependence of the conductivity on two dimensions, i.e. the radius from the source and the angle of the propagation path with the LOS. This divergence from one-dimensionality begins at a small fraction of a nanosecond for a sea-level burst. This effect will also be present in high-altitude bursts, however, determination of its onset time and magnitude requires high-altitude computations which have not yet been done.

  6. Requirement for erythroblast-macrophage protein (Emp) in definitive erythropoiesis.

    Science.gov (United States)

    Soni, Shivani; Bala, Shashi; Hanspal, Manjit

    2008-01-01

    Emp, erythroblast-macrophage protein was initially identified as a mediator of erythroblast-macrophage interactions during erythroid differentiation. More recent studies have shown that targeted disruption of Emp leads to abnormal erythropoiesis in the fetal liver, and fetal demise. To further address the activity of Emp in the hematopoietic lineage in adult bone marrow, we conducted fetal liver HSC reconstitution assay. Emp null fetal liver cells were transplanted into lethally irradiated wild-type sibling mice, and assessed the erythropoietic activity. We found that Emp null cells rescued lethally irradiated mice with efficiency comparable to that of wild-type cells. However, the recipients of Emp null cells showed abnormal erythropoiesis as indicated by the presence of persistent anemia, extensive extramedullary erythropoiesis, and increased apoptosis of erythroid precursors. Extramedullary erythropoiesis suggests perturbed interactions between the Emp-deficient hematopoietic cells and the wild-type niche. Furthermore, in spleen colony-forming unit assays, proliferation rates of the Emp null cells were greater than those of the wild-type cells. Similarly, in vitro burst-forming unit-erythroid and colony-forming unit-erythroid assays showed increased erythroid colony numbers from Emp null livers. Morphologic examination showed that Emp null CFU-E-derived erythroblasts were immature compared to those derived from wild-type CFU-Es, suggesting that loss of Emp function in erythroid cells results in impaired proliferation and terminal differentiation. These results demonstrate that Emp plays a cell intrinsic role in the erythroid lineage.

  7. 更亮更美更平价投影机——Epson EMP-S1H/EMP-TW10H

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Epson最新推出的两都家用入门级投影机——EMP-S1H及EMP-TW10H,都是上一代EMP-S1和EMP-TW10的加强版.同时加强了显示的亮度与对比度。奠中.EMP-S1H拥有较亮的1,400流明亮度及500:1的对比度;而EMP-TW10H则拥有鞍高显示品质的1,200流明及800:1对比度。而最重要的.就是两机分别都比上一

  8. 更亮更美更平价投影机 Epson EMP-S1H / EMP-TW10H

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Epson最新推出的两部家用入门级投影机——EMP-SIH及EMP-TW10H,都是一代EMP-S1和EMP-TW10的加强版,同时加强了显示的亮度与对比度,其中,EMP-S1H拥有较高的1.400流明亮度及500:1的对比度;而EMP-TW10H则拥有较高显示器质的1.200流明及800:1对比度。而最重要的,就是两机分别都比上一

  9. The development of the time dependence of the nuclear EMP electric field

    Energy Technology Data Exchange (ETDEWEB)

    Eng, C

    2009-10-30

    The nuclear electromagnetic pulse (EMP) electric field calculated with the legacy code CHAP is compared with the field given by an integral solution of Maxwell's equations, also known as the Jefimenko equation, to aid our current understanding on the factors that affect the time dependence of the EMP. For a fair comparison the CHAP current density is used as a source in the Jefimenko equation. At first, the comparison is simplified by neglecting the conduction current and replacing the standard atmosphere with a constant density air slab. The simplicity of the resultant current density aids in determining the factors that affect the rise, peak and tail of the EMP electric field versus time. The three dimensional nature of the radiating source, i.e. sources off the line-of-sight, and the time dependence of the derivative of the current density with respect to time are found to play significant roles in shaping the EMP electric field time dependence. These results are found to hold even when the conduction current and the standard atmosphere are properly accounted for. Comparison of the CHAP electric field with the Jefimenko electric field offers a direct validation of the high-frequency/outgoing wave approximation.

  10. Plasmodium falciparum Expressing Domain Cassette 5 Type PfEMP1 (DC5-PfEMP1) Bind PECAM1

    DEFF Research Database (Denmark)

    Berger, Sanne S; Turner, Louise; Wang, Christian W

    2013-01-01

    associated with the expression of particular subsets of PfEMP1 molecules. PfEMP1 are grouped into subtypes based on upstream sequences and the presence of semi-conserved PfEMP1 domain compositions named domain cassettes (DCs). Earlier studies have indicated that DC5-containing PfEMP1 (DC5-PfEMP1) are more......, and show that two genetically different parasite lines expressing DC5-PfEMP1 bind PECAM1, and that anti-DC5-specific antibodies inhibit binding of DC5-PfEMP1-expressing parasites to transformed human bone marrow endothelial cells (TrHBMEC). We also show that antibodies against each of the four domains...

  11. The High Time Resolution Universe Survey - V: Single-pulse energetics and modulation properties of 315 pulsars

    CERN Document Server

    Burke-Spolaor, S; Bailes, M; Bates, S D; Bhat, N D R; Burgay, M; Champion, D J; D'Amico, N; Keith, M J; Kramer, M; Levin, L; Possenti, S Milia A; Stappers, B; van Straten, W

    2012-01-01

    We report on the pulse-to-pulse energy distributions and phase-resolved modulation properties for catalogued pulsars in the southern High Time Resolution Universe intermediate-latitude survey. We selected the 315 pulsars detected in a single-pulse search of this survey, allowing a large sample unbiased regarding any rotational parameters of neutron stars. We found that the energy distribution of many pulsars is well-described by a log-normal distribution, with few deviating from a small range in log-normal scale and location parameters. Some pulsars exhibited multiple energy states corresponding to mode changes, and implying that some observed "nulling" may actually be a mode-change effect. PSRJ1900-2600 was found to emit weakly in its previously-identified "null" state. We found evidence for another state-change effect in two pulsars, which show bimodality in their nulling time scales; that is, they switch between a continuous-emission state and a single-pulse-emitting state. Large modulation occurs in many ...

  12. Effects of electromagnetic pulse on serum element levels in rat.

    Science.gov (United States)

    Li, Kangchu; Ma, Shirong; Ren, Dongqing; Li, Yurong; Ding, Guirong; Liu, Junye; Guo, Yao; Guo, Guozhen

    2014-04-01

    Electromagnetic pulse (EMP) was a potentially harmful factor to the human body, and a biological dosimetry to evaluate effects of EMP is necessary. Little is known about effects of EMP on concentration of macro and trace elements in serum so far. In this study, Sprague-Dawley rats were randomly divided into 50-kV/m EMP-exposed group (n = 10), 100-kV/m EMP-exposed group (n = 10), 200-kV/m EMP-exposed group (n = 40), and the sham-exposed group (n = 20). The macro and trace element concentrations in serum were examined at 6, 12, 24, and 48 h after EMP exposure at different electric field intensities. Compared with the sham-exposed groups, the concentration of sodium (Na), potassium (K), magnesium (Mg), calcium (Ca), zinc (Zn), copper (Cu), iron (Fe), selenium (Se), and manganese (Mn) in rat serum was not changed significantly within 48 h after 200 pulses of EMP exposure at electric field intensity of 50, 100, and 200 kV/m although the K level was decreased and the Ca level was increased with the electric field intensity of EMP increasing. In addition, there was a tendency that the Zn level was decreased with the time going on within 48 h after EMP exposure. Under our experimental conditions, EMP exposure cannot affect the concentration of macro and trace elements in rat serum. There was no time-effect or dose-effect relationship between EMP exposure and serum element levels. The macro and trace elements in serum are not suitable endpoints of biological dosimetry of EMP.

  13. Empédocles de Agrimento

    OpenAIRE

    García Gual, Carlos

    2014-01-01

    A través de la presentación y comentario de los textos de Empédocles, el autor se propone restaurar la complejidad de la vida y obra de este maestro de la verdad, más allá del reduccionismo al que ha estado sometido su estudio, o de la imagen de incoherencia que para algunos eruditos tiene su obra e incluso de las artificiosas explicaciones o intentos de conciliación de esa incoherencia. Tanto por las fuentes de su saber como por su peculiar situación histórica, así como por su universal amor...

  14. Numerical simulation of compact intracloud discharge and generated electromagnetic pulse

    Science.gov (United States)

    Babich, L. P.; Bochkov, E. I.; Kutsyk, I. M.

    2015-06-01

    Using the concept of the relativistic runaway electron avalanche, numerical simulation of compact intracloud discharge as a generator of powerful natural electromagnetic pulses (EMPs) in the HF-UHF range was conducted. We evaluated the numbers of electrons initiating the avalanche, with which the calculated EMP characteristics are consistent with measured ones. The discharge capable of generating EMPs produces runaway electrons in numbers close to those in the source of terrestrial γ-flashes (TGF) registered in the nearest space, which may be an argument for a joint EMP and TGF source.

  15. fs/ns dual-pulse LIBS analytic survey for copper-based alloys

    Energy Technology Data Exchange (ETDEWEB)

    Santagata, A. [CNR-IMIP, Unita Operativa di Potenza, Zona Industriale di Tito Scalo, 85050 Tito Scalo, PZ (Italy)], E-mail: santagata@pz.imip.cnr.it; Teghil, R. [Universita degli Studi della Basilicata, Dipartimento di Chimica, Via N. Sauro 85, 85100 Potenza (Italy); Albano, G.; Spera, D.; Villani, P. [CNR-IMIP, Unita Operativa di Potenza, Zona Industriale di Tito Scalo, 85050 Tito Scalo, PZ (Italy); De Bonis, A. [Universita degli Studi della Basilicata, Dipartimento di Chimica, Via N. Sauro 85, 85100 Potenza (Italy); Parisi, G.P. [CNR-IMIP, Unita Operativa di Potenza, Zona Industriale di Tito Scalo, 85050 Tito Scalo, PZ (Italy); Galasso, A. [Universita degli Studi della Basilicata, Dipartimento di Chimica, Via N. Sauro 85, 85100 Potenza (Italy)

    2007-12-15

    The quantitative analytic capability of a fs/ns dual-pulse Laser-Induced Breakdown Spectroscopy technique, based on the orthogonal reheating of a fs-laser ablation plume by a ns-laser pulse, is presented. In this work, it is shown how the effect played by the delay times between the two laser beams can vary the analytical response of this dual-pulse LIBS configuration. In order to address this task, the Sn, Pb and Zn calibration curves of five certified copper-based samples have been investigated. These calibration curves have been obtained, in air at atmospheric pressure, by integrating the emission data collected in two different inter-pulse delay zones, one in the delay interval of 1-41 {mu}s, the other within the range of 46-196 {mu}s. For drawing the species calibration curves, the emission intensities of the considered Pb(I), Sn(I) and Zn(I) electronic transitions have been normalized with a non-resonant Cu(I) emission line. The experimental results have shown that, by varying the inter-pulse delay between the two laser beams, complementary analytical results can be induced. By considering at once all data acquired within the inter-pulse delay time of 1-196 {mu}s, this hypothesis has been strengthened. The calibration curves obtained in this way are characterized by excellent linear regression coefficients (0.988-0.999) despite of the large Sn, Pb and Zn compositional variation of the targets employed. The results presented reveal, for the first time, that, by taking into account the role played by the inter-pulse delay time between the two laser beams, the fs/ns dual-pulse LIBS configuration here used can be improved and provide very good opportunities for performing quantitative analysis of copper-based alloys.

  16. Oxygen and pulse oximetry in childhood pneumonia: a survey of healthcare providers in resource-limited settings.

    Science.gov (United States)

    Ginsburg, Amy Sarah; Van Cleve, William C; Thompson, Mary I W; English, Mike

    2012-10-01

    Globally, pneumonia is the leading cause of death in children provider perceptions and practices regarding their role in childhood pneumonia, we conducted a survey using a convenience sampling strategy targeting clinicians working in resource-limited countries. Most respondents were physicians from public district and provincial hospitals with access to oxygen and pulse oximetry; however, reported therapeutic use for childhood pneumonia was low. Common barriers included insufficient supply, competition for use, lack of policies, guidelines and training and perceived high cost. Despite the frequency of hypoxemia, the inaccuracy of clinical predictors, the poor outcome hypoxemia portends and the effectiveness of pulse oximetry and oxygen in childhood pneumonia, our data indicate that these tools may be underused in resource-limited settings.

  17. A statistical survey of dayside pulsed ionospheric flows as seen by the CUTLASS Finland HF radar

    Directory of Open Access Journals (Sweden)

    K. A. McWilliams

    Full Text Available Nearly two years of 2-min resolution data and 7- to 21-s resolution data from the CUTLASS Finland HF radar have undergone Fourier analysis in order to study statistically the occurrence rates and repetition frequencies of pulsed ionospheric flows in the noon-sector high-latitude ionosphere. Pulsed ionospheric flow bursts are believed to be the ionospheric footprint of newly reconnected geomagnetic field lines, which occur during episodes of magnetic flux transfer to the terrestrial magnetosphere - flux transfer events or FTEs. The distribution of pulsed ionospheric flows were found to be well grouped in the radar field of view, and to be in the vicinity of the radar signature of the cusp footprint. Two thirds of the pulsed ionospheric flow intervals included in the statistical study occurred when the interplanetary magnetic field had a southward component, supporting the hypothesis that pulsed ionospheric flows are a reconnection-related phenomenon. The occurrence rate of the pulsed ionospheric flow fluctuation period was independent of the radar scan mode. The statistical results obtained from the radar data are compared to occurrence rates and repetition frequencies of FTEs derived from spacecraft data near the magnetopause reconnection region, and to ground-based optical measurements of poleward moving auroral forms. The distributions obtained by the various instruments in different regions of the magnetosphere were remarkably similar. The radar, therefore, appears to give an unbiased sample of magnetopause activity in its routine observations of the cusp footprint.

    Key words: Magnetospheric physics (magnetosphere-ionosphere interactions; plasma convection; solar wind-magnetosphere interactions

  18. Psicoterapia y Procesos Empáticos

    Directory of Open Access Journals (Sweden)

    Zagmutt, A

    2008-07-01

    Full Text Available Se revisa la situación actual de la terapia cognitiva postulando una continuidad desde los enfoques conductistas hasta el posracionalismo en términos de la complejidad evolutiva de los modelos en relación a su concepción de la mente. Desde los mas objetivistas y representacionales hasta los mas autorreferenciales. En segundo lugar se hace referencia a la relevancia de la dimensión corporal para la comprensión de la experiencia humana de acuerdo a los datos invariantes que surgen desde los avances en el conocimiento. En tercer lugar se ofrecen algunas observaciones de como estos hallazgos pueden ser incorporados a nuestro quehacer como clínicos enfatizando la relevancia de los procesos empáticos.

  19. Implementing network constraints in the EMPS model

    Energy Technology Data Exchange (ETDEWEB)

    Helseth, Arild; Warland, Geir; Mo, Birger; Fosso, Olav B.

    2010-02-15

    This report concerns the coupling of detailed market and network models for long-term hydro-thermal scheduling. Currently, the EPF model (Samlast) is the only tool available for this task for actors in the Nordic market. A new prototype for solving the coupled market and network problem has been developed. The prototype is based on the EMPS model (Samkjoeringsmodellen). Results from the market model are distributed to a detailed network model, where a DC load flow detects if there are overloads on monitored lines or intersections. In case of overloads, network constraints are generated and added to the market problem. Theoretical and implementation details for the new prototype are elaborated in this report. The performance of the prototype is tested against the EPF model on a 20-area Nordic dataset. (Author)

  20. Effect of Electromagnetic Pulse Exposure on Brain Micro Vascular Permeability in Rats

    Institute of Scientific and Technical Information of China (English)

    GUI-RONG DING; KANG-CHU LI; XIAO-WU WANG; YONG-CHUN ZHOU; LIAN-BO QIU; JUAN TAN; SHENG-LONG XU; GUO-ZHEN GUO

    2009-01-01

    Objective To observe the effect of electromagnetic pulse (EMP) exposure on cerebral micro vascular permeability in rats.Methods The whole-body of male Sprague-Dawley rats were exposed or sham exposed to 200 pulses or 400 pulses (1 Hz) of EMP at 200 kV/m.At 0.5,1,3,6,and 12 h after EMP exposure,the permeability of cerebral micro vascular was detected by transmission electron microscopy and immunohistochemistry using lanthanum nitrate and endogenous albumin as vascular tracers,respectively. Results The lanthanum nitrate tracer was limited to the micro vascular lumen with no lanthanum nitrate or albumin tracer extravasation in control rat brain.After EMP exposure,the lanthanum nitrate ions reached the tight junction,basal lamina and pericapillary tissue.Similarly,the albumin immunopositive staining was identified in pericapillary tissue.The changes in brain micro vascular permeability were transient,the leakage of micro vascular vessels appeared at 1 h,and reached its peak at 3 h,and nearly recovered at 12 h,after EMP exposure.In addition,the leakage of micro vascular was more obvious after exposure of EMP at 400 pulses than after exposure of EMP at 200 pulses. Conclusion Exposure to 200 and 400 pulses (1 Hz) of EMP at 200 kV/m can increase cerebral micro vascular permeability in rats,which is recoverable.

  1. Pulse pressure and heart rate in patients with metabolic syndrome across Europe: insights from the GOOD survey.

    Science.gov (United States)

    Perlini, S; Naditch-Brule, L; Farsang, C; Zidek, W; Kjeldsen, S E

    2013-07-01

    The Global Cardiometabolic Risk Profile in Patients with hypertension disease (GOOD) survey investigated the global cardiometabolic risk profile in 3464 adult outpatients with hypertension across 289 sites in 12 European countries. The pulse pressure and heart rate profile of the survey population was evaluated according to the presence or absence of metabolic syndrome and/or type 2 diabetes mellitus. History and treatment of hypertension were not counted as criteria for metabolic syndrome as they applied to all patients. Out of the 3370 recruited patients, 1033 had metabolic syndrome and 1177 had neither metabolic syndrome nor diabetes. When compared with patients with no metabolic syndrome or diabetes, patients with metabolic syndrome had higher pulse pressure (59±14 vs. 55±14 mm Hg) and heart rate (75.2±11.0 vs. 72.5±10.0 beats per min) (Ppulse pressure, which may at least in part reflect increased arterial stiffness and increased sympathetic tone. This may contribute, to some extent, to explaining the increased cardiovascular risk attributed to the presence of metabolic syndrome.

  2. Conducting ethanobotanical surveys: an example from Ghana on plants used for the protection of stored cereals and pulses (NRI Bulletin 77)

    OpenAIRE

    Cobbinah, J.R.; Moss, C.; Golob, P.; Belmain, S. R.

    1999-01-01

    A survey was undertaken in the Ashanti Region of Ghana to assess the use of plant materials with insecticidal and repellent properties on local farms. Emphasis was placed on plant materials used to protect stores containing cereals and pulses. A total of 27 plant species were recorded as having protective qualities against storage pests of cereals and pulses. The species Chromolaena odorata (L.) [siam weed], Azadirachta indica A. Juss [neem] and Capsicum annuum L. [chilli pepper] were the mos...

  3. Inertial confinement fusion driven by long wavelength electromagnetic pulses

    Institute of Scientific and Technical Information of China (English)

    Baifei; Shen; Xueyan; Zhao; Longqing; Yi; Wei; Yu; Zhizhan; Xu

    2013-01-01

    A method for inertial confinement fusion driven by powerful long wavelength electromagnetic pulses(EMPs), such as CO2 laser pulses or high power microwave pulses, is proposed. Due to the high efficiency of generating such long wavelength electromagnetic pulses, this method is especially important for the future fusion electricity power. Special fuel targets are designed to overcome the shortcomings of the long wavelength electromagnetic pulses.

  4. Nuclear pulse. III - Playing a wild card

    Science.gov (United States)

    Broad, W. J.

    1981-06-01

    Implications of the phenomenon of electromagnetic pulse (EMP), a high-voltage by-product of nuclear explosions in space which could render useless unprotected communications equipment and power grids over a wide area, for the feasibility of conducting a limited nuclear war by the United States are discussed. Arguments on the one hand that the effects of EMP demand direct investigation and should be protected against by the hardening of U.S. military communications are summarized and contrasted with those on the other hand which assert that the presence of EMP, as well as other exotic nuclear effects, would, despite any attempts at hardening, make it impossible to maintain the precision of command and control necessary for a limited nuclear action against Soviet military targets. Uncertainties about Soviet intentions in regard to the use of EMP as a weapon are also pointed out.

  5. X-Shooter GTO: Chemical analysis of a sample of EMP candidates

    CERN Document Server

    Caffau, E; François, P; Spite, M; Spite, F; Zaggia, S; Ludwig, H -G; Monaco, L; Sbordone, L; Cayrel, R; Hammer, F; Randich, S; Hill, V; Molaro, P

    2011-01-01

    Context: Extremely metal-poor stars (EMP) are very rare objects that hold in their atmospheres the fossil record of the chemical composition of the early phases of Galactic evolution. Finding these objects and determining their chemical composition provides important constraints on these early phases. Aims: Using a carefully designed selection method, we chose a sample of candidate EMP stars from the low resolution spectra of the Sloan Digital Sky Survey and observed them with X-Shooter at the VLT to confirm their metallicities and determine abundances for as many elements as possible. Method: The X-Shooter spectra are analysed by means of one-dimensional, plane-parallel, hydrostatic model atmospheres. Corrections for the granulation effects are computed using CO5BOLD hydrodynamical simulations. Results: All the candidates are confirmed to be EMP stars, proving the efficiency of our selection method within about 0.5 dex. The chemical composition of this sample is compatible with those of brighter samples, sug...

  6. Bioelectromagnetic Effects of EMP: Preliminary Findings

    Science.gov (United States)

    1988-06-01

    return- stroke fields. Geophysical Research Letters 7(11): 955-958. ........ Wertheimer, N. and E. Leeper (1979). Electrical wiring configurations and...distances of the test stations from the FMr source in the field study. The lack of effects was attributed to the combination of extremely short pulse

  7. Improving high-altitude emp modeling capabilities by using a non-equilibrium electron swarm model to monitor conduction electron evolution

    Science.gov (United States)

    Pusateri, Elise Noel

    An Electromagnetic Pulse (EMP) can severely disrupt the use of electronic devices in its path causing a significant amount of infrastructural damage. EMP can also cause breakdown of the surrounding atmosphere during lightning discharges. This makes modeling EMP phenomenon an important research effort in many military and atmospheric physics applications. EMP events include high-energy Compton electrons or photoelectrons that ionize air and produce low energy conduction electrons. A sufficient number of conduction electrons will damp or alter the EMP through conduction current. Therefore, it is important to understand how conduction electrons interact with air in order to accurately predict the EMP evolution and propagation in the air. It is common for EMP simulation codes to use an equilibrium ohmic model for computing the conduction current. Equilibrium ohmic models assume the conduction electrons are always in equilibrium with the local instantaneous electric field, i.e. for a specific EMP electric field, the conduction electrons instantaneously reach steady state without a transient process. An equilibrium model will work well if the electrons have time to reach their equilibrium distribution with respect to the rise time or duration of the EMP. If the time to reach equilibrium is comparable or longer than the rise time or duration of the EMP then the equilibrium model would not accurately predict the conduction current necessary for the EMP simulation. This is because transport coefficients used in the conduction current calculation will be found based on equilibrium reactions rates which may differ significantly from their non-equilibrium values. We see this deficiency in Los Alamos National Laboratory's EMP code, CHAP-LA (Compton High Altitude Pulse-Los Alamos), when modeling certain EMP scenarios at high altitudes, such as upward EMP, where the ionization rate by secondary electrons is over predicted by the equilibrium model, causing the EMP to short

  8. EMP Threats to US National Security: Congressional Responses

    Science.gov (United States)

    Huessy, Peter

    2011-04-01

    The US Congress is considering how best to respond to concerns that EMP is a real and present danger to US security. The threats come from a variety of areas: solar storms, non-nuclear EMP from man-made machines and devices; and nuclear EMP from a nuclear device exploded above CONUS or other critical areas important to the United States and its allies. Responses have to date included passage in the House of legislation to protect the electrical grid in the United States from such threats and hearings before the Homeland Security Committee. Additional efforts include examining missile defense responses, protection of the maritime domain, and hardening of US military and related civilian infrastructure. The House of Representatives has also examined what Europe, the European Union and NATO, both government and private industry, have done in these areas. Complicating matters are related issues of cyber-security and overall homeland security priorities.

  9. A cross-country Exchange Market Pressure (EMP) dataset.

    Science.gov (United States)

    Desai, Mohit; Patnaik, Ila; Felman, Joshua; Shah, Ajay

    2017-06-01

    The data presented in this article are related to the research article titled - "An exchange market pressure measure for cross country analysis" (Patnaik et al. [1]). In this article, we present the dataset for Exchange Market Pressure values (EMP) for 139 countries along with their conversion factors, ρ (rho). Exchange Market Pressure, expressed in percentage change in exchange rate, measures the change in exchange rate that would have taken place had the central bank not intervened. The conversion factor ρ can interpreted as the change in exchange rate associated with $1 billion of intervention. Estimates of conversion factor ρ allow us to calculate a monthly time series of EMP for 139 countries. Additionally, the dataset contains the 68% confidence interval (high and low values) for the point estimates of ρ's. Using the standard errors of estimates of ρ's, we obtain one sigma intervals around mean estimates of EMP values. These values are also reported in the dataset.

  10. Electromagnetic Pulse - A Catastrophic Threat to the Homeland

    Science.gov (United States)

    2011-03-24

    which could be very destructive to the electrical power grid. 3 A high altitude electromagnetic pulse ( HEMP ), caused by the detonation of a...recreate EMP on a large enough scale to draw reliable conclusions. But history has provided us with a few historical events to learn from. In 1962 the...circuit board systems used today are much more sensitive and vulnerable to EMP than the solid state, vacuum tube systems used 50 years ago

  11. EMP: A Diagnostic and Therapeutic Approach.

    Science.gov (United States)

    Stephens, Jill

    A 2-year study examined the relevance of English-as-a-second-language instructional materials for students in health care fields. The study gathered specific information on common medical activities requiring the use of English and identified problem areas. A random sample of students of medicine, pharmacy, and research science was surveyed, the…

  12. Plasminogen activator inhibitor-1 fused with erythropoietin (EPO) mimetic peptide (EMP) enhances the EPO activity of EMP.

    Science.gov (United States)

    Kuai, L; Wu, C; Qiu, Q; Zhang, J; Zhou, A; Wang, S; Zhang, H; Song, Q; Liao, S; Han, Y; Liu, J; Ma, Z

    2000-08-01

    Erythropoietin (EPO) mimetic peptide (EMP) encoding sequence was inserted into the gene of plasminogen activator inhibitor-1 (PAI-1) between Ala348 and Pro349 (P2'-P3'), generating a novel gene, PAI-1/EMP (PMP). This was cloned into pET32a expression vector, fused with TrxA peptide in the vector, and a 63-kDa protein was expressed in inclusion bodies with an expression level >50%. The TrxA/PMP protein was purified by Ni-NTA-agarose metal-ligand affinity chromatography to a purity >90%, showing a single, silver-stained band on SDS-PAGE. Using a reticulocyte counting assay, the EPO activity of PMP was determined to be 5,000 IU/mg, 2,500-fold that of EMP.

  13. EMP Shielding Properties of Conduit Systems and Related Hardware

    Science.gov (United States)

    1975-06-01

    degradation in performance. An integral part of this EMP-shielding system is the condut runs that carry the instrumentation and power cables between the...Practically, however, heat loss from the chamber combined with the thermal inertia of the chamber and thermostat cause these values to vary with time. These

  14. Susceptibility of personal computer systems to electromagnetic pulses with double exponential character

    Directory of Open Access Journals (Sweden)

    M. Camp

    2004-01-01

    Full Text Available In this paper the susceptibility of personal computer systems to fast transient electromagnetic pulses with double exponential pulse shapes (EMP, UWB is determined. The influence of the computer generation, RAM-values, different program states and the pulse shape, as well as the destruction thresholds of single PC-components (CPU, RAM, BIOS, Mainboard have been investigated.

  15. Steroid hormone regulation of EMP2 expression and localization in the endometrium

    Directory of Open Access Journals (Sweden)

    Williams Carmen J

    2008-04-01

    Full Text Available Abstract Background The tetraspan protein epithelial membrane protein-2 (EMP2, which mediates surface display of diverse proteins, is required for endometrial competence in blastocyst implantation, and is uniquely correlated with poor survival from endometrial adenocarcinoma tumors. Because EMP2 is differentially expressed in the various stages of the murine and human estrous cycle, we tested the hypothesis that the steroid hormones progesterone and estrogen influence EMP2 expression and localization. Methods Frozen human proliferative and secretory endometrium were collected and analyzed for EMP2 expression using SDS-PAGE/Western blot analysis. The response of EMP2 to progesterone and estradiol was determined using a combination of real-time PCR, SDS-PAGE/Western blot analysis, and confocal immunofluorescence in the human endometrial carcinoma cell line RL95-2. To confirm the in vitro results, ovariectomized mice were treated with progesterone or estradiol, and EMP2 expression was analyzed using immunohistochemistry. Results Within normal human endometrium, EMP2 expression is upregulated in the secretory phase relative to the proliferative phase. To understand the role of steroid hormones on EMP2 expression, we utilized RL95-2 cells, which express both estrogen and progesterone receptors. In RL95-2 cells, both estradiol and progesterone induced EMP2 mRNA expression, but only progesterone induced EMP2 protein expression. To compare steroid hormone regulation of EMP2 between humans and mice, we analyzed EMP2 expression in ovarectomized mice. Similar to results observed in humans, progesterone upregulated endometrial EMP2 expression and induced EMP2 translocation to the plasma membrane. Estradiol did not promote translocation to the cell surface, but moderately induced EMP2 expression in cytoplasmic compartments in vivo. Conclusion These findings suggest that targeting of EMP2 to specific locations under the influence of these steroid hormones may

  16. Control over spectral characteristics of electromagnetic pulses

    Energy Technology Data Exchange (ETDEWEB)

    Bolotov, V.N., E-mail: bolotov@ukrpost.u [Karazin National University, Kharkov 61007 (Ukraine); Fedorchenko, V.D.; Gritsenko, V.I.; Muratov, V.I. [Karazin National University, Kharkov 61007 (Ukraine)

    2010-05-01

    A theory was elaborated on transition radiation (TR) from electron bunches that pass through diaphragms of various geometries. At the base of this theory are induced charges and currents in the conductive diaphragms that are generated by electron bunches. An important role of the earth points of diaphragms was proven experimentally and theoretically. A feasibility study was made on controlling the spectra of electromagnetic pulses (EMP) and their directivity patterns. A new configuration for the diaphragms was proposed: twin diaphragms. Calculated and experimentally measured were spectra of such EMPs that were formed by the induced conduction current during the flight of the electron bunch through the twin diaphragms.

  17. Hospitalidade Organizacional: Panorama Teórico-Empírico

    Directory of Open Access Journals (Sweden)

    José Alberto Carvalho dos Santos Claro

    2015-10-01

    Full Text Available O objetivo deste texto é o de apresentar as discussões teórico-conceituais sobre Hospitalidade, particularmente a vertente da Hospitalidade Organizacional (HO, que se ocupa das relações hospitaleiras no ambiente do espaço de trabalho. Trata-se de um estudo exploratório, baseado em revisão bibliográfica, seguida de pesquisa de campo por meio de levantamento junto a gestores de pessoas (especialistas ou juízes, sobre o entendimento do tema, visando contribuir para a futura criação de escala de medida para quantificar o grau de HO em uma organização. Como resultado, apresenta-se contribuição teórica para o amadurecimento desta tendência organizacional e indicadores que poderão ser futuramente usados em estudos empíricos e na construção de um instrumento com escala validada para ser utilizada em organizações em qualquer setor de atividade econômica. Palavras-chave: Hospitalidade. Hospitalidade Organizacional. Gestão de Pessoas.Organizational Hospitality: Theorical and Empirical Developments This paper aim is to present the theoretical and conceptual discussions about hospitality, particularly the  Organizational Hospitality (OH, which is concerned with the hospitable relations in the workplace. It’s an exploratory study, based on literature review and field survey with people managers (experts or judges about their understanding about the question. The result indicates that the development of organizational indicators could be used in future empirical studies and to the construction of a validated scale that can be used in any sector of the economic activity. Keywords: Hospitality. Organizational Hospitality. People Management. Indicators.José Alberto Carvalho dos Santos Claro – Doutor. Professor Adjunto da Universidade Federal de São Paulo [UNIFESP], Campus Baixada Santista, Santos, SP. Endereço Lattes http://lattes.cnpq.br/0865792662046289 E-mail: albertoclaro@albertoclaro.pro.br  

  18. A randomized phase II trial of personalized peptide vaccine plus low dose estramustine phosphate (EMP) versus standard dose EMP in patients with castration resistant prostate cancer.

    Science.gov (United States)

    Noguchi, Masanori; Kakuma, Tatsuyuki; Uemura, Hirotsugu; Nasu, Yasutomo; Kumon, Hiromi; Hirao, Yasuhiko; Moriya, Fukuko; Suekane, Shigetaka; Matsuoka, Kei; Komatsu, Nobukazu; Shichijo, Shigeki; Yamada, Akira; Itoh, Kyogo

    2010-07-01

    Personalized peptide vaccination (PPV) combined with chemotherapy could be a novel approach for many cancer patients. In this randomized study, we evaluated the anti-tumor effect and safety of PPV plus low-dose estramustine phosphate (EMP) as compared to standard-dose EMP for HLA-A2- or -A24-positive patients with castration resistant prostate cancer. Patients were randomized into groups receiving either PPV plus low-dose EMP (280 mg/day) or standard-dose EMP (560 mg/day). After disease progression, patients were switched to the opposite regime. The primary end point was progression-free survival (PFS). We randomly assigned 28 patients to receive PPV plus low-dose EMP and 29 patients to receive standard-dose EMP. Nineteen events in the PPV group and 20 events in the EMP group occurred during the first treatment. Median PFS for the first treatment was 8.5 months in the PPV group and 2.8 months in the EMP group with a hazard ratio (HR) of 0.28 (95% CI, 0.14-0.61; log-rank P = 0.0012), while there was no difference for median PFS for the second treatment. The HR for overall survival was 0.3 (95% CI, 0.1-0.91) in favor of the PPV plus low-dose EMP group (log-rank, P = 0.0328). The PPV plus low-dose EMP was well tolerated without major adverse effects and with increased levels of IgG and cytotoxic-T cell responses to the vaccinated peptides. PPV plus low-dose EMP was associated with an improvement in PSA-based PFS as compared to the standard-dose EMP alone.

  19. Samnett: the EMPS model with power flow constraints: implementation details

    Energy Technology Data Exchange (ETDEWEB)

    Helseth, Arild; Warland, Geir; Mo, Birger; Fosso, Olav B.

    2011-12-15

    This report describes the development and implementation of Samnett. Samnett is a new prototype for solving the coupled market and transmission network problem. The prototype is based on the EMPS model (Samkjoeringsmodellen). Results from the market model are distributed to a detailed transmission network model, where a DC power flow detects if there are overloads on monitored lines or interconnections. In case of overloads, power flow constraints are generated and added to the market problem. This report is an updated version of TR A6891 {sup I}mplementing Network Constraints in the EMPS model{sup .} It further elaborates on theoretical and implementation details in Samnett, but does not contain the case studies and file descriptions presented in TR A6891.(auth)

  20. Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency.

    Science.gov (United States)

    Williams, Carmen J; Chu, Alison; Jefferson, Wendy N; Casero, David; Sudhakar, Deepthi; Khurana, Nevil; Hogue, Claire P; Aryasomayajula, Chinmayi; Patel, Priya; Sullivan, Peggy; Padilla-Banks, Elizabeth; Mohandessi, Shabnam; Janzen, Carla; Wadehra, Madhuri

    2017-03-14

    Epithelial membrane protein-2 (EMP2) is a tetraspan protein predicted to regulate placental development. Highly expressed in secretory endometrium and trophectoderm cells, previous studies suggest that it may regulate implantation by orchestrating the surface expression of integrins and other membrane proteins. In order to test the role of EMP2 in pregnancy, mice lacking EMP2 (Emp2(-/-) ) were generated. Emp2(-/-) females are fertile but have reduced litter sizes when carrying Emp2(-/-) but not Emp2(+/-) fetuses. Placentas of Emp2(-/-) fetuses exhibit dysregulation in pathways related to neoangiogenesis, coagulation, and oxidative stress, and have increased fibrin deposition and altered vasculature. Given that these findings often occur due to placental insufficiency resulting in an oxygen-poor environment, the expression of hypoxia-inducible factor-1 alpha (HIF-1α) was examined. Placentas from Emp2(-/-) fetuses had increased total HIF-1α expression in large part through an increase in uterine NK (uNK) cells, demonstrating a unique interplay between uNK cells and trophoblasts modulated through EMP2. To determine if these results translated to human pregnancy, placentas from normal, term deliveries or those complicated by placental insufficiency resulting in intrauterine growth restriction (IUGR) were stained for EMP2. EMP2 was significantly reduced in both villous and extravillous trophoblast populations in IUGR placentas. Experiments in vitro using human trophoblast cells lines indicate that EMP2 modulates angiogenesis by altering HIF-1α expression. Our results reveal a novel role for EMP2 in regulating trophoblast function and vascular development in mice and humans and suggest it may be a new biomarker for placental insufficiency.

  1. 强光环境也适用——Epson EMP-61/EMP-81

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    如果大家有需要在较亮的环境中投射大型的影像,一般家用的入门级投影机.因为亮度不太够.所以在早上室外光线能打入屋时未必够用,但Epson即将推出的这两部亮度和分辨率都较高的EMP-61/EMP-81就最适合这种环境下使用。两部投影机同时拥有高达2,000流明的高亮度.并分别拥有800×600和更高的1,024×758高

  2. 78 FR 58605 - Proposed Collection; Comment Request for Form 8453-EMP, Form 8453-F, Form 8453-FE, Form 8879-F...

    Science.gov (United States)

    2013-09-24

    ... Internal Revenue Service Proposed Collection; Comment Request for Form 8453-EMP, Form 8453-F, Form 8453-FE, Form 8879-F, and 8879-EMP. AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request...- file Return; Form 8453-EMP, Employment Tax Declaration for an IRS e- file Return; Form 8879-EMP, IRS...

  3. Pulse on Pulse

    DEFF Research Database (Denmark)

    Schmidt, Ulrik; Carlson, Merete

    2012-01-01

    Pulse on Pulse” investigates the relation between signifying processes and non-signifying material dynamism in the installation Pulse Room (2006-) by Mexican Canadian artist Rafael Lozano-Hemmer. In Pulse Room the sense of pulse is ambiguous. Biorhythms are transmitted from the pulsing energy...... and pulsating ‘room’. Hence, the visitors in Pulse Room are invited into a complex scenario that continuously oscillates between various aspects of signification (the light bulbs representing individual lives; the pulse itself as the symbolic ‘rhythm of life’) and instants of pure material processuality...... a multilayered sense of time and space that is central to the sensory experience of Pulse Room as a whole. Pulse Room is, at the very same time, an anthropomorfized archive of a past intimacy and an all-encompassing immersive environment modulating continuously in real space-time....

  4. 投影机 爱普生EMP-TW20

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    在爱普生的EMP-TW系列家用投影机中,EMP-TW20是最新的一款低端产品。在外观方面,它仍保持了爱普生EMP-TW投影机简浩高质感的设计风格,而且乳白色的机身可以很容易地与家居环境融合.

  5. Exponential megapriming PCR (EMP) cloning--seamless DNA insertion into any target plasmid without sequence constraints.

    Science.gov (United States)

    Ulrich, Alexander; Andersen, Kasper R; Schwartz, Thomas U

    2012-01-01

    We present a fast, reliable and inexpensive restriction-free cloning method for seamless DNA insertion into any plasmid without sequence limitation. Exponential megapriming PCR (EMP) cloning requires two consecutive PCR steps and can be carried out in one day. We show that EMP cloning has a higher efficiency than restriction-free (RF) cloning, especially for long inserts above 2.5 kb. EMP further enables simultaneous cloning of multiple inserts.

  6. Exponential megapriming PCR (EMP cloning--seamless DNA insertion into any target plasmid without sequence constraints.

    Directory of Open Access Journals (Sweden)

    Alexander Ulrich

    Full Text Available We present a fast, reliable and inexpensive restriction-free cloning method for seamless DNA insertion into any plasmid without sequence limitation. Exponential megapriming PCR (EMP cloning requires two consecutive PCR steps and can be carried out in one day. We show that EMP cloning has a higher efficiency than restriction-free (RF cloning, especially for long inserts above 2.5 kb. EMP further enables simultaneous cloning of multiple inserts.

  7. Pulse on Pulse

    DEFF Research Database (Denmark)

    Schmidt, Ulrik; Carlson, Merete

    2012-01-01

    and pulsating ‘room’. Hence, the visitors in Pulse Room are invited into a complex scenario that continuously oscillates between various aspects of signification (the light bulbs representing individual lives; the pulse itself as the symbolic ‘rhythm of life’) and instants of pure material processuality......“Pulse on Pulse” investigates the relation between signifying processes and non-signifying material dynamism in the installation Pulse Room (2006-) by Mexican Canadian artist Rafael Lozano-Hemmer. In Pulse Room the sense of pulse is ambiguous. Biorhythms are transmitted from the pulsing energy...... of the visitor’s beating heart to the blink of a fragile light bulb, thereby transforming each light bulb into a register of individual life. But at the same time the blinking light bulbs together produce a chaotically flickering light environment composed by various layers of repetitive rhythms, a vibrant...

  8. Influence of irradiation on release of endothelial microparticles (EMP) in vitro.

    Science.gov (United States)

    Neuber, Christin; Pufe, Johanna; Pietzsch, Jens

    2015-01-01

    Survivors of Hodgkin's disease as well as of breast and lung cancer are at risk of radiation-associated cardiovascular disease. Recent studies demonstrated a correlation between cardiovascular risk factors and circulating endothelial microparticles (EMP) and thereby suggest increased EMP levels in circulation to be an early biomarker of endothelial dysfunction and cardiovascular risk. This prompted us to analyze the amount of EMP released by human aortic endothelial cells (HAEC) after exposure to different doses of X-ray (0.4, 2, 4, 6, and 20 Gy) using antibodies against the endothelial cell markers CD31, CD144, and CD146 by flow cytometry. In this pilot experiment only CD146 proved appropriate for quantification of HAEC-derived EMP. Exposure of HAEC to different doses of X-ray did not significantly influence formation of CD146-positive EMP. However, low doses (0.4 Gy) tended to decrease EMP formation, whereas higher doses (2 or 4 Gy) slightly increased release of CD146-positive EMP. By contrast, inflammatory activation of HAEC by TPA significantly increased EMP release about 15-fold (P EMP did not prove a suitable biomarker for radiation-induced endothelial dysfunction in vitro.

  9. Epson新品投影机EMP-81/61

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Epson EMP-81和EMP-61设计上注重为用户提供实用的功能和简便自如的操作,提供了新型遥控器、安全保护功能、短距离投影、EMP监控、直接投影、自动梯形校正和快速开机、关机功能,EMP-81和EMP-61还提供了适合不同投影环境的多种投影模式供选择。

  10. DEVELOPING LINGUISTIC SKILLS AND ABILITIES IN EMP STUDENTS

    Directory of Open Access Journals (Sweden)

    Nataša Milosavljević

    2012-03-01

    Full Text Available English for medical purposes falls within the category of discipline-specific language learning. It is characterized by specific linguistic features and requires specific study that is possible to carry out using specially designed programmes. Reading skill is one way of learning strategy of English for medical purposes. Most often, students use this skill in order to obtain information for some particular topic from the area of medical science, or because they need some sort of instruction in order to carry out certain task. Vocabulary acquisition plays a very important role in EMP teaching. It is achieved best through learning vocabulary in context, rather than in isolation. One of the most important questions in EMP teaching is related to what grammatical constructions should be analysed and emphasised. Some types of these activities would include, for example, asking students to find examples of one particular structure in the text or fill in the blanks with the missing forms such as tenses, passive forms, prepositions, etc. Speaking skill represents productive skill the aim of which is communication. In order for foreign language communication to be suucessful, a student should know linguistic and cultural features of native speakers and follow certain rules and conventions that are not easy to define. It is of crucial importance that during teaching process students develop strategies and techniques that will help them use linguistic structures fluently, apply language in different situations, take part in discussions, and use acquired vocabulary in accurate and precise way.

  11. Strategies, Protections and Mitigations for Electric Grid from Electromagnetic Pulse Effects

    Energy Technology Data Exchange (ETDEWEB)

    Foster, Rita Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States); Frickey, Steven Jay [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-01-01

    The mission of DOE’s Office of Electricity Delivery and Energy Reliability (OE) is to lead national efforts to modernize the electricity delivery system, enhance the security and reliability of America’s energy infrastructure and facilitate recovery from disruptions to the energy supply. One of the threats OE is concerned about is a high-altitude electro-magnetic pulse (HEMP) from a nuclear explosion and eletro-magnetic pulse (EMP) or E1 pulse can be generated by EMP weapons. DOE-OE provides federal leadership and technical guidance in addressing electric grid issues. The Idaho National Laboratory (INL) was chosen to conduct the EMP study for DOE-OE due to its capabilities and experience in setting up EMP experiments on the electric grid and conducting vulnerability assessments and developing innovative technology to increase infrastructure resiliency. This report identifies known impacts to EMP threats, known mitigations and effectiveness of mitigations, potential cost of mitigation, areas for government and private partnerships in protecting the electric grid to EMP, and identifying gaps in our knowledge and protection strategies.

  12. Strategies, Protections and Mitigations for Electric Grid Affets from Electro-Magnetic Pulse

    Energy Technology Data Exchange (ETDEWEB)

    Foster, Rita Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States); Frickey, Steven Jay [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2016-01-01

    The mission of DOE’s Office of Electricity Delivery and Energy Reliability (OE) is to lead national efforts to modernize the electricity delivery system, enhance the security and reliability of America’s energy infrastructure and facilitate recovery from disruptions to the energy supply. One of the threats OE is concerned about is a high-altitude electro-magnetic pulse (HEMP) from a nuclear explosion and eletro-magnetic pulse (EMP) or E1 pulse can be generated by EMP weapons. DOE-OE provides federal leadership and technical guidance in addressing electric grid issues. The Idaho National Laboratory (INL) was chosen to conduct the EMP study for DOE-OE due to its capabilities and experience in setting up EMP experiments on the electric grid and conducting vulnerability assessments and developing innovative technology to increase infrastructure resiliency. This report identifies known impacts to EMP threats, known mitigations and effectiveness of mitigations, potential cost of mitigation, areas for government and private partnerships in protecting the electric grid to EMP, and identifying gaps in our knowledge and protection strategies.

  13. Interface Control Document for the EMPACT Module that Estimates Electric Power Transmission System Response to EMP-Caused Damage

    Energy Technology Data Exchange (ETDEWEB)

    Werley, Kenneth Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Mccown, Andrew William [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)ory

    2016-06-26

    The EPREP code is designed to evaluate the effects of an Electro-Magnetic Pulse (EMP) on the electric power transmission system. The EPREP code embodies an umbrella framework that allows a user to set up analysis conditions and to examine analysis results. The code links to three major physics/engineering modules. The first module describes the EM wave in space and time. The second module evaluates the damage caused by the wave on specific electric power (EP) transmission system components. The third module evaluates the consequence of the damaged network on its (reduced) ability to provide electric power to meet demand. This third module is the focus of the present paper. The EMPACT code serves as the third module. The EMPACT name denotes EMP effects on Alternating Current Transmission systems. The EMPACT algorithms compute electric power transmission network flow solutions under severely damaged network conditions. Initial solutions are often characterized by unacceptible network conditions including line overloads and bad voltages. The EMPACT code contains algorithms to adjust optimally network parameters to eliminate network problems while minimizing outages. System adjustments include automatically adjusting control equipment (generator V control, variable transformers, and variable shunts), as well as non-automatic control of generator power settings and minimal load shedding. The goal is to evaluate the minimal loss of customer load under equilibrium (steady-state) conditions during peak demand.

  14. 78 FR 35073 - Compass Efficient Model Portfolios, LLC and Compass EMP Funds Trust; Notice of Application

    Science.gov (United States)

    2013-06-11

    ... COMMISSION Compass Efficient Model Portfolios, LLC and Compass EMP Funds Trust; Notice of Application June 4.... Applicants: Compass Efficient Model Portfolios, LLC (the ``Adviser'') and Compass EMP Funds Trust (``the... perspective of the investor, the role of the Subadvisers is comparable to that of the individual...

  15. Promoter Hypermethylation of the EMP3 Gene in a Series of 229 Human Gliomas

    Directory of Open Access Journals (Sweden)

    Marta Mellai

    2013-01-01

    Full Text Available The epithelial membrane protein 3 (EMP3 is a candidate tumor suppressor gene in the critical region 19q13.3 for several solid tumors, including tumors of the nervous systems. The aim of this study was to investigate the EMP3 promoter hypermethylation status in a series of 229 astrocytic and oligodendroglial tumors and in 16 GBM cell lines. The analysis was performed by methylation-specific PCR and capillary electrophoresis. Furthermore, the EMP3 expression at protein level was evaluated by immunohistochemistry and Western blotting analysis. Associations of EMP3 hypermethylation with total 1p/19q codeletion, MGMT promoter hypermethylation, IDH1/IDH2 and TP53 mutations, and EGFR amplification were studied, as well as its prognostic significance. The EMP3 promoter hypermethylation has been found in 39.5% of gliomas. It prevailed in low-grade tumors, especially in gliomas with an oligodendroglial component, and in sGBMs upon pGBMs. In oligodendroglial tumors, it was strongly associated with both IDH1/IDH2 mutations and total 1p/19q codeletion and inversely with EGFR gene amplification. No association was found with MGMT hypermethylation and TP53 mutations. In the whole series, the EMP3 hypermethylation status correlated with 19q13.3 loss and lack of EMP3 expression at protein level. A favorable prognostic significance on overall survival of the EMP3 promoter hypermethylation was found in patients with oligodendroglial tumors.

  16. EMP-1 promotes tumorigenesis of NSCLC through PI3K/AKT pathway.

    Science.gov (United States)

    Lai, Senyan; Wang, Guihua; Cao, Xiaonian; Li, Zhaoming; Hu, Junbo; Wang, Jing

    2012-12-01

    This study examined the role of EMP-1 in tumorigenesis of non-small cell lung carcinoma (NSCLC) and the possible mechanism. Specimens were collected from 28 patients with benign lung diseases and 28 with NSCLC, and immunohistochemically detected to evaluate the correlation of EMP-1 expression to the clinical features of NSCLC. Recombinant adenovirus was constructed to over-express EMP-1 and then infect PC9 cells. Cell proliferation was measured by Ki67 staining. Western blotting was performed to examine the effect of EMP-1 on the PI3K/AKT signaling. Moreover, tumor xenografts were established by subcutaneous injection of PC9 cell suspension (about 5×10(7)/mL in 100 μL of PBS) into the right hind limbs of athymic nude mice. The results showed EMP-1 was significantly up-regulated in NSCLC patients as compared with those with benign lung diseases. Over-expression of EMP-1 promoted proliferation of PC9 cells, which coincided with the activation of the PI3K/AKT pathway. EMP-1 promoted the growth of xenografts of PC9 cells in athymic nude mice. It was concluded that EMP-1 expression may contribute to the development and progress of NSCLC by activating PI3K/AKT pathway.

  17. EMP Needs of Medical Undergraduates in a Saudi Context

    CERN Document Server

    Javid, Choudhary Zahid

    2014-01-01

    Needs analysis (NA) is an information gathering process (Nunan 1988) that is executed to identify the learners reasons for learning a language so that they might be taught the relevant teaching materials. This study was undertaken at College of Medicine and Medical Sciences (CMMS), Taif University during the academic year 2008 to identify English for Medical Purposes (EMP) needs of the medical undergraduates. Multiple methods of data collection such as exploratory interviews, observations and a questionnaire were used to find out their linguistic needs and the data were triangulated to validate the findings. The findings offered significant insights in selecting suitable course contents to teach English to freshmen medical undergraduates of CMMS. It has been reported that 1) the students lacked the required level of English language proficiency, 2) they needed reading and speaking skills more than others and 3) the data analysis also helped identify the most important language tasks in the context of CMMS. Bo...

  18. EPSON(爱普生)EMP-TW2000

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    EPSON不久前推出的EMP—TW10003 LCD 1080p高清投影机自问世以来一直是人们关注的焦点之一,当热潮还未降温,EPSON紧接着又发布了最新的旗舰机种EMP-TW2000。EMP—TW2000同样是一款3LCD的1080P高清投影机,但采用了新开发的Crystal C1ear Fine(C2Fine)D7投影芯片,并且提供了对HDMI1.3a连接的支持,此外还运用了提高画面黑色表现的DEEPBLACK技术和大大扩展色域表现的x.v.Color技术,

  19. SEMICONDUCTOR DEVICES: EMP injection damage effects of a bipolar transistor and its relationship between the injecting voltage and energy

    Science.gov (United States)

    Xiaowen, Xi; Changchun, Chai; Xingrong, Ren; Yintang, Yang; Bing, Zhang; Xiao, Hong

    2010-04-01

    The response of a bipolar transistor (BJT) under a square-wave electromagnetic pulse (EMP) with different injecting voltages is investigated. Adopting the curve fitting method, the relationship between the burnout time, the damage energy and the injecting voltage is obtained. Research shows that the damage energy is not a constant value, but changes with the injecting voltage level. By use of the device simulator Medici, the internal behavior of the burned device is analyzed. Simulation results indicate that the variation of the damage energy with injecting voltage is caused by the distribution change of hot spot position under different injection levels. Therefore, the traditional way to evaluate the trade-off between the burnout time and the injecting voltage is not comprehensive due to the variation of the damage energy.

  20. EMP injection damage effects of a bipolar transistor and its relationship between the injecting voltage and energy

    Energy Technology Data Exchange (ETDEWEB)

    Xi Xiaowen; Chai Changchun; Ren Xingrong; Yang Yintang; Zhang Bing; Hong Xiao, E-mail: xixiaowen523103@163.co [Key Laboratory of Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi' an 710071 (China)

    2010-04-15

    The response of a bipolar transistor (BJT) under a square-wave electromagnetic pulse (EMP) with different injecting voltages is investigated. Adopting the curve fitting method, the relationship between the burnout time, the damage energy and the injecting voltage is obtained. Research shows that the damage energy is not a constant value, but changes with the injecting voltage level. By use of the device simulator Medici, the internal behavior of the burned device is analyzed. Simulation results indicate that the variation of the damage energy with injecting voltage is caused by the distribution change of hot spot position under different injection levels. Therefore, the traditional way to evaluate the trade-off between the burnout time and the injecting voltage is not comprehensive due to the variation of the damage energy. (semiconductor devices)

  1. A compra de votos: uma aproximação empírica

    Directory of Open Access Journals (Sweden)

    Bruno Wilhelm Speck

    2003-05-01

    Full Text Available O artigo aborda o fenômeno da compra de votos no contexto histórico e apresenta dados de um levantamento empírico realizado através de uma pesquisa de opinião após as eleições municipais no Brasil no ano 2000. São discutidas questões relacionadas ao significado da compra de votos no conjunto das questões ligadas à lisura do processo eleitoral. O texto aborda também os problemas enfrentados na pesquisa em função do assunto abordado e soluções metodológicas encontradas.The author presents the results of a national survey on vote buying during the local elections in Braszil in 2000. In his analysis he places vote buying into the broader historical perspective of electoral and other forms of manipulation and corruption. Specific methodological questions of surveys on such critical questions like fraude and corruption are discussed

  2. Analysis of the research development on HPM/EMP protection%强电磁防护技术研究进展

    Institute of Scientific and Technical Information of China (English)

    刘培国; 刘晨曦; 谭剑锋; 董雁飞; 易波

    2015-01-01

    高功率微波武器是现代战场上极具杀伤性的攻击手段。针对现代武器装备的强电磁防护问题,通过介绍高功率微波武器及防护研究发展进程,结合传统电磁防护方法,分析电磁自适应防护、微波加固和硬件演化等前沿技术手段,从电路防护和空间防护的角度出发,论述射频电磁防护单元、皮秒级电磁脉冲抑制器件、频率选择表面等强电磁防护器件和装置的研究成果以及强电磁防护的新材料,并从系统综合防护、设备潜在失效性、强电磁防护标准3个方面对强电磁防护技术的发展给出相应的建议。%High power microwave(HPM)and electromagnetic pulse(EMP)weapons both are highly lethal weapons in modern warfare. In order to protect modern weaponry agalnst HPM/EMP attack,frontier tech⁃nologies and methods such as adaptive electromagnetic protection,microwave reinforcement,and evolv⁃able hardware are reviewed in this paper,where conventional protection methods are first described based on the development process of HPM/EMP weaponry and the protection research. Research achievements such as radio frequency electromagnetic protection units,picosecond EMP suppression device,and fre⁃quency selective surface are summarized,with new protection materials being presented in the end. Also, suggestions are given for the future development direction of HPM/EMP protection technology from the per⁃spective of systematic protection,potential loss of effectiveness of equipment,as well as the standard on HPM/EMP protection.

  3. Federal Aviation Administration Electromagnetic Pulse (EMP) Protection Study: A Reexamination and Update,

    Science.gov (United States)

    1979-11-01

    Transistor 2t291 4 x10-3 Ge PXP Audio Transistor 2N331 1 x10-2 Ge PU? Audio Transistor 2H226 1.5 X0- Ge PNP Audio Transistor 2N224...5 x10_ 3 Ge PNP Audio Transistor13 7A 1,6 210" Si PNP Audio Transistor 2041 2 16 02 Ge PNP Audio Transistor 2N526 1.2 x10- " Ge PH? Audio Transistor ...MPH Switching Transistors 2N661 a x8( - 4 Ge M?’ Switching Transistors 21017 2 IO -4 Ge PNP Switching

  4. Electromagnetic Pulse (EMP) Handbook for Air Force Communications Service Communications-Electronics-Meteorological Engineers

    Science.gov (United States)

    1976-11-01

    OF INoV ,, OUSOLRT% APPROVAL PAGE This report has been reviewed and in approved for publication and dis- tribution. GRL T. HARIS Chief, Electronics G...the collision of gamma rays with air molecules or other materials . The collision knocks electrons free of the air molecules and causes the electrons...penetrations of such conductors. Ground currents entering the vicinity of a structure through conductive materials are conducted around the structure through a

  5. Neuroprotective effects of sevoflurane against electromagnetic pulse-induced brain injury through inhibition of neuronal oxidative stress and apoptosis.

    Directory of Open Access Journals (Sweden)

    Bin Deng

    Full Text Available Electromagnetic pulse (EMP causes central nervous system damage and neurobehavioral disorders, and sevoflurane protects the brain from ischemic injury. We investigated the effects of sevoflurane on EMP-induced brain injury. Rats were exposed to EMP and immediately treated with sevoflurane. The protective effects of sevoflurane were assessed by Nissl staining, Fluoro-Jade C staining and electron microscopy. The neurobehavioral effects were assessed using the open-field test and the Morris water maze. Finally, primary cerebral cortical neurons were exposed to EMP and incubated with different concentration of sevoflurane. The cellular viability, lactate dehydrogenase (LDH release, superoxide dismutase (SOD activity and malondialdehyde (MDA level were assayed. TUNEL staining was performed, and the expression of apoptotic markers was determined. The cerebral cortexes of EMP-exposed rats presented neuronal abnormalities. Sevoflurane alleviated these effects, as well as the learning and memory deficits caused by EMP exposure. In vitro, cell viability was reduced and LDH release was increased after EMP exposure; treatment with sevoflurane ameliorated these effects. Additionally, sevoflurane increased SOD activity, decreased MDA levels and alleviated neuronal apoptosis by regulating the expression of cleaved caspase-3, Bax and Bcl-2. These findings demonstrate that Sevoflurane conferred neuroprotective effects against EMP radiation-induced brain damage by inhibiting neuronal oxidative stress and apoptosis.

  6. Consumer Electronics Testing to Fast-Rise EMP (Electromagnetic Pulse) (VEMPS (Vertical Electromagnetic Pulse Simulator) 2 Development)

    Science.gov (United States)

    1989-06-01

    complete descrip- tion of all test configurations used at FEMPS, see Erler and Dancz [7]. Three types of test data were collected throughout the test...under HDL contract DAAL02-87-C-0052 (November 1987). 7. J. Erler and J. Dancz, Consumer Electronics Updated Test Plan, Sci- ence Applications...International Corporation, SAIC-102-87-021, under HDL contract DAAL02-86-D-0041 (15 July 1987). 8. J. Erler and W. Byers, FEMPS Consumer Electronics Tests

  7. Absence of erythroblast macrophage protein (Emp) leads to failure of erythroblast nuclear extrusion.

    Science.gov (United States)

    Soni, Shivani; Bala, Shashi; Gwynn, Babette; Sahr, Kenneth E; Peters, Luanne L; Hanspal, Manjit

    2006-07-21

    In mammals, the functional unit for definitive erythropoiesis is the erythroblastic island, a multicellular structure composed of a central macrophage surrounded by developing erythroblasts. Erythroblast-macrophage interactions play a central role in the terminal maturation of erythroblasts, including enucleation. One possible mediator of this cell-cell interaction is the protein Emp (erythroblast macrophage protein). We used targeted gene inactivation to define the function of Emp during hematopoiesis. Emp null embryos die perinatally and show profound alterations in the hematopoietic system. A dramatic increase in the number of nucleated, immature erythrocytes is seen in the peripheral blood of Emp null fetuses. In the fetal liver virtually no erythroblastic islands are observed, and the number of F4/80-positive macrophages is substantially reduced. Those present lack cytoplasmic projections and are unable to interact with erythroblasts. Interestingly, wild type macrophages can bind Emp-deficient erythroblasts, but these erythroblasts do not extrude their nuclei, suggesting that Emp impacts enucleation in a cell autonomous fashion. Previous studies have implicated the actin cytoskeleton and its reorganization in both erythroblast enucleation as well as in macrophage development. We demonstrate that Emp associates with F-actin and that this interaction is important in the normal distribution of F-actin in both erythroblasts and macrophages. Thus, Emp appears to be required for erythroblast enucleation and in the development of the mature macrophages. The availability of an Emp null model provides a unique experimental system to study the enucleation process and to evaluate the function of macrophages in definitive erythropoiesis.

  8. SURVEY

    DEFF Research Database (Denmark)

    SURVEY er en udbredt metode og benyttes inden for bl.a. samfundsvidenskab, humaniora, psykologi og sundhedsforskning. Også uden for forskningsverdenen er der mange organisationer som f.eks. konsulentfirmaer og offentlige institutioner samt marketingsafdelinger i private virksomheder, der arbejder...... med surveys. Denne bog gennemgår alle surveyarbejdets faser og giver en praktisk indføring i: • design af undersøgelsen og udvælgelse af stikprøver, • formulering af spørgeskemaer samt indsamling og kodning af data, • metoder til at analysere resultaterne...

  9. Environmental management plan (EMP) for Melamchi water supply project, Nepal.

    Science.gov (United States)

    Khadka, Ram B; Khanal, Anil B

    2008-11-01

    More than 1.5 million people live in the Kathmandu valley. The valley is facing an extreme shortage of water supply. At the same time the demand is escalating rapidly. To address this issue of scarcity of water, the government of Nepal has proposed a project of inter-basin transfer of water from Melamchi River located 40 km north-east of the Kathmandu valley. The project will cover two districts and three municipalities and will potentially have significant impacts on the environment. In accordance with the Environmental Protection Regulation of Nepal (1997), the Melamchi Water Supply Project (MWSP) has undergone an EIA during the feasibility study stage of the proposed project. The recommendations contained in the EIA were integrated into the project design for implementation in 2006. This paper summarizes the background of MWSP, the environmental concerns described in the EIA and the status of Environmental Management Plan (EMP) developed to address environmental compliance and other issues involving participation and support of the local people. This paper also provides some lessons to learn on the modalities of addressing the demands and grievances of the local people concerning environmental management.

  10. EMP combination chemotherapy and low-dose monotherapy in advanced prostate cancer.

    Science.gov (United States)

    Kitamura, Tadaichi; Nishimatsu, Hiroaki; Hamamoto, Toshiaki; Tomita, Kyoichi; Takeuchi, Takumi; Ohta, Nobutaka

    2002-02-01

    Many chemotherapeutic regimens combined with estramustine phosphate (EMP) have been elaborated for the treatment of hormone-refractory prostate cancer over 30 years. However, older EMP-based combination chemotherapies with vinblastine, vinorelbine, doxorubicin or cyclophosphamide showed relatively low PSA response rate (25-58%) accompanied with high toxicities. On the other hand, newly developed EMP-based combination regimens with etoposide, pacitaxel, carboplatin or docetaxel demonstrated promising PSA response rate (43-77%) with moderate to severe toxicity in the rate of thromboembolic event (5-18%) and of neutropenia (9-41%). Treatment-related death was less in the latter combination group (5/615, 0.8%) than that in the former group (3/234, 1.3%). Of note, in the docetaxel combination with EMP, PSA response rate is as high as 77% with high rate (41%) of neutropenia but no treatment-related death was observed. Docetaxel combination with EMP seems to be the best regimen, though not completely justified by randomized trials, to be selected in the modern era, which will be followed by paclitaxel, carboplatin and EMP combination with PSA response rate of 71%. In addition, an interim report in 83 patients was presented. They were not consecutively enrolled but were treated on low-dose EMP monotherapy for previously untreated advanced prostate cancer in Department of Urology of Tokyo University and our 21 affiliated hospitals. Overall PSA response rate was as high as 93.4% out of 76 assessable patients. However, overall toxicity rate was abnormally high (39.5%) with drug discontinuation rate of 32.1%. The reason of low drug compliance may be attributed to gastrointestinal symptoms. To overcome the low drug compliance, appropriate patients for EMP administration should be selected by using gene analysis on the basis of sophisticated tailor-made medicine.

  11. High throughput functional assays of the variant antigen PfEMP1 reveal a single domain in the 3D7 Plasmodium falciparum genome that binds ICAM1 with high affinity and is targeted by naturally acquired neutralizing antibodies.

    Directory of Open Access Journals (Sweden)

    Andrew V Oleinikov

    2009-04-01

    Full Text Available Plasmodium falciparum-infected erythrocytes bind endothelial receptors to sequester in vascular beds, and binding to ICAM1 has been implicated in cerebral malaria. Binding to ICAM1 may be mediated by the variant surface antigen family PfEMP1: for example, 6 of 21 DBLbetaC2 domains from the IT4 strain PfEMP1 repertoire were shown to bind ICAM1, and the PfEMP1 containing these 6 domains are all classified as Group B or C type. In this study, we surveyed binding of ICAM1 to 16 DBLbetaC2 domains of the 3D7 strain PfEMP1 repertoire, using a high throughput Bioplex assay format. Only one DBL2betaC2 domain from the Group A PfEMP1 PF11_0521 showed strong specific binding. Among these 16 domains, DBL2betaC2(PF11_0521 best preserved the residues previously identified as conserved in ICAM1-binding versus non-binding domains. Our analyses further highlighted the potential role of conserved residues within predominantly non-conserved flexible loops in adhesion, and, therefore, as targets for intervention. Our studies also suggest that the structural/functional DBLbetaC2 domain involved in ICAM1 binding includes about 80 amino acid residues upstream of the previously suggested DBLbetaC2 domain. DBL2betaC2(PF11_0521 binding to ICAM1 was inhibited by immune sera from east Africa but not by control US sera. Neutralizing antibodies were uncommon in children but common in immune adults from east Africa. Inhibition of binding was much more efficient than reversal of binding, indicating a strong interaction between DBL2betaC2(PF11_0521 and ICAM1. Our high throughput approach will significantly accelerate studies of PfEMP1 binding domains and protective antibody responses.

  12. EMP-1 is a junctional protein in a liver stem cell line and in the liver.

    Science.gov (United States)

    Lee, Hsuan-Shu; Sherley, James L; Chen, Jeremy J W; Chiu, Chien-Chang; Chiou, Ling-Ling; Liang, Ja-Der; Yang, Pan-Chyr; Huang, Guan-Tarn; Sheu, Jin-Chuan

    2005-09-09

    In an attempt to discover cell markers for liver stem cells, a cDNA microarray analysis was carried out to compare the gene expression profiles between an adult liver stem cell line, Lig-8, and mature hepatocytes. Several genes in the categories of extracellular matrix, cell membrane, cell adhesion, transcription factor, signal molecule, transporter, and metabolic enzyme were shown to be differentially expressed in Lig-8 cells. Among them, epithelial membrane protein (EMP)-1 has been previously implicated with stem cell phenotypes. Antiserum to EMP-1 was produced to localize its expression. On monolayers of Lig-8 cells, EMP-1 was expressed along the intercellular border. In the liver harboring proliferating oval cells, the liver progenitors, EMP-1 was localized as ribbon bands, a staining pattern for epithelial junctions, all the way through bile duct epithelia, oval cell ductules, and into peri-hepatocytic regions. These peri-hepatocytic regions were proved to be bile canaliculi by co-localization of EMP-1 and dipeptidyl peptidase IV, an enzyme located on bile canaliculi. This report is the first to indicate EMP-1 to be a junctional protein in the liver.

  13. Iron-regulated biofilm formation in Staphylococcus aureus Newman requires ica and the secreted protein Emp.

    Science.gov (United States)

    Johnson, Miranda; Cockayne, Alan; Morrissey, Julie A

    2008-04-01

    Staphylococcus aureus biofilm formation is induced in iron-restricted growth conditions in vitro. In this study, we showed that Emp and Eap play important roles in low-iron-induced biofilm formation of S. aureus Newman. Eap and Emp are secreted proteins which are non-covalently attached to the S. aureus cell surface and have previously been implicated in a number of aspects of S. aureus pathogenesis. We showed here that the transcription of these important virulence factors is induced by growth in low-iron medium, reflective of the in vivo environment. Our results show that iron regulation of Eap and Emp is Fur independent. However, Fur is required for full induction of eap and emp expression in low-iron conditions. In this study, we demonstrated that in addition to Fur, low-iron-induced biofilm formation requires Sae, Agr, and SarA. In iron-restricted growth conditions, Sae and Agr are essential for Emp and Eap expression and hence for biofilm formation, whereas SarA appears to have a less-significant role. We also showed that expression of the ica operon is required for biofilm formation in iron-restricted growth conditions. We demonstrated that in fact, ica is required for the expression of the important multifunctional virulence determinants eap and emp.

  14. Electromagnetic pulses produced by expanding laser-produced Au plasma

    Directory of Open Access Journals (Sweden)

    De Marco Massimo

    2015-06-01

    Full Text Available The interaction of an intense laser pulse with a solid target produces large number of fast free electrons. This emission gives rise to two distinct sources of the electromagnetic pulse (EMP: the pulsed return current through the holder of the target and the outflow of electrons into the vacuum. A relation between the characteristics of laser-produced plasma, the target return current and the EMP emission are presented in the case of a massive Au target irradiated with the intensity of up to 3 × 1016 W/cm2. The emission of the EMP was recorded using a 12 cm diameter Moebius loop antennas, and the target return current was measured using a new type of inductive target probe (T-probe. The simultaneous use of the inductive target probe and the Moebius loop antenna represents a new useful way of diagnosing the laser–matter interaction, which was employed to distinguish between laser-generated ion sources driven by low and high contrast laser pulses.

  15. analysis of large electromagnetic pulse simulators using the electric field integral equation method in time domain

    CERN Document Server

    Jamali, J; Moini, R; Sadeghi, H

    2002-01-01

    A time-domain approach is presented to calculate electromagnetic fields inside a large Electromagnetic Pulse (EMP) simulator. This type of EMP simulator is used for studying the effect of electromagnetic pulses on electrical apparatus in various structures such as vehicles, a reoplanes, etc. The simulator consists of three planar transmission lines. To solve the problem, we first model the metallic structure of the simulator as a grid of conducting wires. The numerical solution of the governing electric field integral equation is then obtained using the method of moments in time domain. To demonstrate the accuracy of the model, we consider a typical EMP simulator. The comparison of our results with those obtained experimentally in the literature validates the model introduced in this paper.

  16. Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division.

    Science.gov (United States)

    Bala, Shashi; Kumar, Ajay; Soni, Shivani; Sinha, Sudha; Hanspal, Manjit

    2006-04-21

    Emp, originally detected in erythroblastic islands, is expressed in numerous cell types and tissues suggesting a functionality not limited to hematopoiesis. To study the function of Emp in non-hematopoietic cells, an epitope-tagged recombinant human Emp was expressed in HEK cells. Preliminary studies revealed that Emp partitioned into both the nuclear and Triton X-100-insoluble cytoskeletal fractions in approximately a 4:1 ratio. In this study, we report investigations of Emp in the nucleus. Sequential extractions of interphase nuclei showed that recombinant Emp was present predominantly in the nuclear matrix. Immunofluorescence microscopy showed that Emp was present in typical nuclear speckles enriched with the spliceosome assembly factor SC35 and partially co-localized with actin staining. Coimmunoprecipitation and GST-pull-down assays confirmed the apparent close association of Emp with nuclear actin. During mitosis, Emp was detected at the mitotic spindle/spindle poles, as well as in the contractile ring during cytokinesis. These results suggest that Emp undergoes dynamic rearrangements within the nuclear architecture that are correlated with cell division.

  17. Integrating ADDIE Instructional Design Models into EMP Teaching%ADDIE 模型在 EMP 教学中的实践研究

    Institute of Scientific and Technical Information of China (English)

    郭书法; 权继振; 汪田田

    2013-01-01

      介绍了国内外关教学设计及其模型的相关研究,把ADDIE教学设计模型引入EMP(English for Medical Purposes)教学,旨在分析个变量之间的关系,优化课堂教学效果。通过ADDIE教学设计模型在EMP教学中的实践研究,探讨了EMP教学中ADDIE教学设计模型各要素的内涵和相互关系。研究发现ADDIE教学设计模型在EMP的教学卓有成效,同时指出EMP作为语言的特殊性,ADDIE教学设计环节的动态变化和ADDIE教学设计模型的生成性、回应性及验证性等内在特点。%After introducing some domestic and overseas researches about the instructional design , this paper integrates ADDIE instructional model into EMP (English for Medical Purposes ) teaching and demonstrates the key elements and their re-lationship in medical students teaching procedure by conducting the case study of ADDIE model in EMP teaching .The results of EMP teaching with ADDIE instructional model are satisfying , the author also suggests that EMP teaching is special in ADDIE model because it is a language teaching process , all the elements in ADDIE model are dynamic and ADDIE instructional model is a generative, responsive and validating process .

  18. A Search for Meteoroid Lunar Impact Generated Electromagnetic Pulses

    Science.gov (United States)

    Kesaraju, Saiveena; Mathews, John D.; Vierinen, Juha; Perillat, Phil; Meisel, David D.

    2016-11-01

    Lunar white light flashes associated with meteoroid impacts are now regularly observed using modest optical instrumentation. In this paper, we hypothesize that the developing, optically-dense hot ejecta cloud associated with these hypervelocity impacts also produce an associated complex plasma component that rapidly evolves resulting in a highly-transient electro magnetic pulse (EMP) in the VHF/UHF spectral region. Discovery of the characteristics and event frequency of impact EMPs would prove interesting to meteoroid flux and complex plasma physics studies especially if EMPs from the same event are detected from at least two locations on the Earth with relative delays appropriate to the propagation paths. We describe a prototype observational search, conducted in May 2014, for meteoroid lunar-impact EMPs that was conducted using simultaneous, overlapping-band, UHF radio observations at the Arecibo (AO; Puerto Rico) and Haystack (HO, Massachusetts, USA) Observatories. Monostatic/bistatic lunar radar imaging observations were also performed with HO transmitting and HO/AO receiving to confirm tracking, the net delay, and the pointing/timing ephemeris at both observatories. Signal analysis was performed using time-frequency signal processing techniques. Although, we did not conclusively identify EMP returns, this search detected possible EMPs and we have confirmed the search paradigm and established the sensitivity of the AO-HO system in detecting the hypothesized events. We have also characterized the difficult radio-frequency interference environment surrounding these UHF observations. We discuss the wide range of terrestrial-origin, Moon-bounce signals that were observed which additionally validate the observational technique. Further observations are contemplated.

  19. Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

    DEFF Research Database (Denmark)

    Duffy, Michael F; Noviyanti, Rintis; Tsuboi, Takafumi;

    2016-01-01

    BACKGROUND: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements...... of functional domains called domain cassettes. Despite their tremendous diversity there is compelling evidence that a restricted subset of PfEMP1s is expressed in severe disease. In this study antibodies from patients with severe and uncomplicated malaria were compared for differences in reactivity with a range...... of PfEMP1s to determine whether antibodies to particular PfEMP1 domains were associated with severe or uncomplicated malaria. METHODS: Parts of expressed var genes in a severe malaria patient were identified by RNAseq and several of these partial PfEMP1 domains were expressed together with others from...

  20. SAPIENS Memo 8: Electromagnetic properties of the EMP simulator SAPIENS

    Science.gov (United States)

    Garmland, S.

    1985-01-01

    The electric and the magnetic fields were measured inside as well as outside an electromagnetic pulse simulator. The measurements confirm the good quality of the simulator design regarding antenna bandwidth, field impedance, homogeneity, polarization, and the effect of the termination field amplitude in the operation volume is 7% lower than the expected value, due to damping between the support structure and the antenna. Radiation diagrams describing the field outside the simulator are presented.

  1. Apontamentos sobre as bases empíricas do desenvolvimento

    Directory of Open Access Journals (Sweden)

    Dieter Rugard Siedenberg

    2013-03-01

    Full Text Available Neste artigo se procura compreender as bases empíricas sobre as quais se fundamentam as teorias do crescimento e do desenvolvimento socioeconômico. Parte-se do pressuposto de que a concepção contemporânea de desenvolvimento, no contexto das ciências sociais (especialmente, das aplicadas, tem raízes que se alimentaram de, pelo menos, três importantes fontes: as contribuições filosóficas da Grécia Antiga, as práticas políticas vigentes na República e no Império Romano e, por fim, as influências exercidas pela Igreja sobre o modo de produção vigente na sociedade medieval. De forma que a proposta deste artigo é abordar, sucintamente, um conjunto de aspectos considerados significativos que, herdados de cada um desses diferentes contextos históricos, contribuíram para a constituição da concepção de desenvolvimento atualmente vigente. O artigo resulta de apontamentos de leituras e percepções decorrentes de tais leituras, tendo em vista a recuperação de um passado remoto que, de um modo geral, influenciou a história recente da humanidade e, de maneira especial, as teorias econômicas que informam a concepção de desenvolvimento hoje dominante.Palavras-chave | Ciências sociais; crescimento econômico; desenvolvimento; história.Código JEL | B15; O10; P16. NOTES ON THE EMPIRICAL BASIS OF DEVELOPMENTAbstractThis paper seeks to understand the empirical basis on which the theories of growth and socioeconomic development are based. The starting point is the assumption that the contemporary concept of development, in the context of the social sciences (especially of the applied ones, has roots that fed on at least three major sources: the philosophical contributions of ancient Greece, the prevailing political practices in the Republic and the Roman Empire, and finally, the influences exerted by the Church on the production mode prevailing in medieval society. So the purpose of this article is to briefly discuss a number of

  2. sae is essential for expression of the staphylococcal adhesins Eap and Emp.

    Science.gov (United States)

    Harraghy, Niamh; Kormanec, Jan; Wolz, Christiane; Homerova, Dagmar; Goerke, Christiane; Ohlsen, Knut; Qazi, Saara; Hill, Philip; Herrmann, Mathias

    2005-06-01

    Eap and Emp are two Staphylococcus aureus adhesins initially described as extracellular matrix binding proteins. Eap has since emerged as being important in adherence to and invasion of eukaryotic cells, as well as being described as an immunomodulator and virulence factor in chronic infections. This paper describes the mapping of the transcription start point of the eap and emp promoters. Moreover, using reporter-gene assays and real-time PCR in defined regulatory mutants, environmental conditions and global regulators affecting expression of eap and emp were investigated. Marked differences were found in expression of eap and emp between strain Newman and the 8325 derivatives SH1000 and 8325-4. Moreover, both genes were repressed in the presence of glucose. Analysis of expression of both genes in various regulatory mutants revealed that sarA and agr were involved in their regulation, but the data suggested that there were additional regulators of both genes. In a sae mutant, expression of both genes was severely repressed. sae expression was also reduced in the presence of glucose, suggesting that repression of eap and emp in glucose-containing medium may, in part, be a consequence of a decrease in expression of sae.

  3. Role of the Emp Pilus Subunits of Enterococcus faecium in Biofilm Formation, Adherence to Host Extracellular Matrix Components, and Experimental Infection.

    Science.gov (United States)

    Montealegre, Maria Camila; Singh, Kavindra V; Somarajan, Sudha R; Yadav, Puja; Chang, Chungyu; Spencer, Robert; Sillanpää, Jouko; Ton-That, Hung; Murray, Barbara E

    2016-05-01

    Enterococcus faecium is an important cause of hospital-associated infections, including urinary tract infections (UTIs), bacteremia, and infective endocarditis. Pili have been shown to play a role in the pathogenesis of Gram-positive bacteria, including E. faecium We previously demonstrated that a nonpiliated ΔempABC::cat derivative of E. faecium TX82 was attenuated in biofilm formation and in a UTI model. Here, we studied the contributions of the individual pilus subunits EmpA, EmpB, and EmpC to pilus architecture, biofilm formation, adherence to extracellular matrix (ECM) proteins, and infection. We identified EmpA as the tip of the pili and found that deletion of empA reduced biofilm formation to the same level as deletion of the empABC operon, a phenotype that was restored by reconstituting in situ the empA gene. Deletion of empB also caused a reduction in biofilm, while EmpC was found to be dispensable. Significant reductions in adherence to fibrinogen and collagen type I were observed with deletion of empA and empB, while deletion of empC had no adherence defect. Furthermore, we showed that each deletion mutant was significantly attenuated in comparison to the isogenic parental strain, TX82, in a mixed-inoculum UTI model (P Emp pilins are important for E. faecium to cause infection in the urinary tract.

  4. Research on fast rise time EMP radiating-wave simulator

    Science.gov (United States)

    Fan, Lisi; Liu, Haitao; Wang, Yun

    2013-03-01

    This paper presents an antenna of High altitude electromagnetic pulse (HEMP) radiating-wave simulator which expands the testing zone larger than the traditional transmission line simulator. The numerical results show that traverse electramagnetic (TEM) antenna can be used to radiate HEMP simulation radiating wave, but in low frequency band the emissive capability is poor. The experiment proves the numerical model is valid. The results of this paper show that TEM antenna can be used to HEMP radiating-wave simulator, and can prove the low frequency radiation capability through resistance loaded method.

  5. Impact of expression of EMP enzymes on glucose metabolism in Zymomonas mobilis.

    Science.gov (United States)

    Chen, Rachel Ruizhen; Agrawal, Manoj; Mao, Zichao

    2013-06-01

    Zymomonas mobilis is the only known microorganism that utilizes the Entner-Doudoroff (ED) pathway anaerobically. In this work, we investigated whether the overexpression of a phosphofructokinase (PFK), the only missing Embden-Meyerhof-Parnas (EMP) pathway enzyme, could establish the pathway in this organism. Introduction of a pyrophosphate-dependent PFK, along with co-expression of homologous fructose-1,6-bisphosphate aldolase and triosephosphate isomerase, did not result in an EMP flux to any appreciable level. However, the metabolism of glucose was impacted significantly. Eight percent of glucose was metabolized to form a new metabolite, dihydroxyacetone. Reducing flux through the ED pathway by as much as 40 % through antisense of a key enzyme, ED aldolase, did not result in a fully functional EMP pathway, suggesting that the ED pathway, especially the lower arm, downstream from glyceraldehyde-3-phosphate, is very rigid, possibly due to redox balance.

  6. EPSON dorimio EMP-TW10H投影机

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    爱普生去年用dorimio品牌第一次发售了dorimio EMP-TW10投影机。具有普及性价格、真实感动的高画质和动人的大画面.加上简单到谁都能使用的理念.因此得到市场的好评。这次爱普生推出了EMP-TW10的升级版EMP-TW10H.在万元级的投影市场上又增加了一个很有竞争力的选手。

  7. Epson高端超便携投影机EMP-740/745

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    Epson高端超便携投影机EMP-740/745是LCD投影机在重量方面的一次跨越,其重量达到了1.7kg(EMP-745重量是1.8kg),成为世界上最轻的LCD投影机之一。而且2500流明的亮度,满足了商务人士对投影机体积和亮度的需求。

  8. The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs

    DEFF Research Database (Denmark)

    Joergensen, Lars M; Salanti, Ali; Dobrilovic, Tina

    2010-01-01

    ABSTRACT: BACKGROUND: Infected humans make protective antibody responses to the PfEMP1 adhesion antigens exported by Plasmodium falciparum parasites to the erythrocyte membrane, but little is known about the kinetics of this antibody-receptor binding reaction or how the topology of PfEMP1 on the ...

  9. Design and Fabrication of a Breadboard, Fully Conductively Cooled, 2-Micron, Pulsed Laser for the 3-D Winds Decadal Survey Mission Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Design and fabricate a space-qualifiable, fully conductively cooled, 2-micron pulsed laser breadboard meeting the projected 3-D Winds mission requirements. Utilize...

  10. Parasites causing cerebral falciparum malaria bind multiple endothelial receptors and express EPCR and ICAM-1-binding PfEMP1

    DEFF Research Database (Denmark)

    Tuikue Ndam, Nicaise; Moussiliou, Azizath; Lavstsen, Thomas

    2017-01-01

    Background: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues. Specific interactions have been described between PfEMP1 and human endothelial proteins CD36, intercellular adhesion molecule-1...

  11. Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

    DEFF Research Database (Denmark)

    Duffy, Michael F; Noviyanti, Rintis; Tsuboi, Takafumi

    2016-01-01

    BACKGROUND: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of fu...

  12. Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

    DEFF Research Database (Denmark)

    Duffy, Michael F; Noviyanti, Rintis; Tsuboi, Takafumi;

    2016-01-01

    BACKGROUND: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants are encoded by var genes and mediate pathogenic cytoadhesion and antigenic variation in malaria. PfEMP1s can be broadly divided into three principal groups (A, B and C) and they contain conserved arrangements of fu...

  13. The relationship between various exposure metrics for elongate mineral particles (EMP) in the taconite mining and processing industry.

    Science.gov (United States)

    Hwang, Jooyeon; Ramachandran, Gurumurthy; Raynor, Peter C; Alexander, Bruce H; Mandel, Jeffrey H

    2014-01-01

    Different dimensions of elongate mineral particles (EMP) have been proposed as being relevant to respiratory health end-points such as mesothelioma and lung cancer. In this article, a methodology for converting personal EMP exposures measured using the National Institute for Occupational Safety and Health (NIOSH) 7400/7402 methods to exposures based on other size-based definitions has been proposed and illustrated. Area monitoring for EMP in the taconite mines in Minnesota's Mesabi Iron Range was conducted using a Micro Orifice Uniform Deposit Impactor (MOUDI) size-fractionating sampler. EMP on stages of the MOUDI were counted and sized according to each EMP definition using an indirect-transfer transmission electron microscopy (ISO Method 13794). EMP were identified using energy-dispersive x-ray and electron diffraction analysis. Conversion factors between the EMP counts based on different definitions were estimated using (1) a linear regression model across all locations and (2) a location-specific ratio of the count based on each EMP definition to the NIOSH 7400/7402 count. The highest fractions of EMP concentrations were found for EMP that were 1-3 μm in length and 0.2-0.5 μm in width. Therefore, the current standard NIOSH Method 7400, which only counts EMP >5 μm in length and ≥ 3 in aspect ratio, may underestimate amphibole EMP exposures. At the same time, there was a high degree of correlation between the exposures estimated according to the different size-based metrics. Therefore, the various dimensional definitions probably do not result in different dose-response relationships in epidemiological analyses. Given the high degree of correlation between the various metrics, a result consistent with prior research, a more reasonable metric might be the measurement of all EMP irrespective of size. [Supplementary materials are available for this article. Go to the publisher's online edition of Journal of Occupational and Environmental Hygiene for the

  14. 爱普生投影机家族再添生力军EMP-S1H

    Institute of Scientific and Technical Information of China (English)

    王颖

    2004-01-01

    @@ 继市场反馈效果非常好的EMP-S1之后,爱普生公司全新推出其的加强版机型--EMP-S1H.此款新机型不但保留了原有EMP-S1的诸多强项,而且专门针对商务使用时较常出现的问题渗入更完善的技术解决与设计理念,从而打造出功能更强大的实用商务投影机EMP-S1H.不相信么?看看以下问题EMP-S1H是如何解决的吧!

  15. Gel shift analysis of the empA promoter region in Vibrio anguillarum

    Directory of Open Access Journals (Sweden)

    Denkin Steven M

    2004-10-01

    Full Text Available Abstract Background The induction of metalloprotease encoded by empA in Vibrio anguillarum occurs at high cell density in salmon intestinal mucus. Previously we have shown that there are significant differences in empA expression in two strains of V. anguillarum, M93Sm and NB10. It is hypothesized that differences in empA regulation are due to differences in binding of regulatory elements. Results Two strains of V. anguillarum, M93Sm and NB10, were examined and compared for the presence of DNA regulatory proteins that bind to and control the empA promoter region. Gel mobility shift assays, using a digoxigenin (DIG-labeled oligomer containing a lux box-like element and the promoter for empA, were done to demonstrate the presence of a DNA-binding protein. Protein extracts from NB10 cells incubated in Luria Bertani broth + 2% NaCl (LB20, nine salts solution + 200 μg/ml mucus (NSSM, 3M (marine minimal medium, or NSS resulted in a gel mobility shift. No gel mobility shift was seen when protein extracts from either LB20- or NSSM-grown M93Sm cells were mixed with the DIG-labeled empA oligomer. The azocasein assay detected protease activity in all incubation conditions for NB10 culture supernatants. In contrast, protease activity was detected in M93Sm culture supernatants only when incubated in NSSM. Since the luxR homologue in V. anguillarum, vanT, has been cloned, sequenced, and shown to be required for protease activity, we wanted to determine if vanT mutants of NB10 exhibit the same gel shift observed in the wild-type. Site-directed mutagenesis was used to create vanT mutants in V. anguillarum M93Sm and NB10 to test whether VanT is involved with the gel mobility shift. Both vanT mutants, M02 and NB02, did not produce protease activity in any conditions. However, protein extracts from NB02 incubated in each condition still exhibited a gel shift when mixed with the DIG-labeled empA oligomer. Conclusions The data demonstrate that protein extracts of V

  16. Detection of electromagnetic pulses produced by hypervelocity micro particle impact plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Close, Sigrid; Lee, Nicolas; Johnson, Theresa; Goel, Ashish; Fletcher, Alexander [Department of Aeronautics and Astronautics, Stanford University, Stanford, California 94305 (United States); Linscott, Ivan; Strauss, David; Lauben, David [Department of Electrical Engineering, Stanford University, Stanford, California 94305 (United States); Srama, Ralf; Mocker, Anna; Bugiel, Sebastian [Institut für Raumfahrtsysteme, Universität Stuttgart, Pfaffenwaldring 29, 70569 Stuttgart (Germany)

    2013-09-15

    Hypervelocity micro particles (mass < 1 ng), including meteoroids and space debris, routinely impact spacecraft and produce plasmas that are initially dense (∼10{sup 28} m{sup −3}), but rapidly expand into the surrounding vacuum. We report the detection of radio frequency (RF) emission associated with electromagnetic pulses (EMPs) from hypervelocity impacts of micro particles in ground-based experiments using micro particles that are 15 orders of magnitude less massive than previously observed. The EMP production is a stochastic process that is influenced by plasma turbulence such that the EMP detection rate that is strongly dependent on impact speed and on the electrical charge conditions at the impact surface. In particular, impacts of the fastest micro particles occurring under spacecraft charging conditions representative of high geomagnetic activity are the most likely to produce RF emission. This new phenomenon may provide a source for unexplained RF measurements on spacecraft charged to high potentials.

  17. EMP径向滑动轴承热弹流分析与仿真%Thermo-elasto-hydrodynamic Analysis and Simulation of EMP Journal Bearing

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    Elastic metal plastic (EMP) journal bearing is a kind of original bearing. Because of the specialty of the composite materials, elastic and thermal deformations of the EMP bush are much larger than that of common metal bush. In this paper, the three-dimensional mathematical model is established to analyze thermo-elasto-hydrodynamics (TEHD) of EMP. The numerical TEHD analysis software is programmed. An example is given to prove the lubrication performance of EMP.

  18. r-Process Elements in EMP stars: Indicators of Inhomogeneous Early Halo Enrichment

    Science.gov (United States)

    Andersen, Johannes; Nordström, Birgitta; Thidemann Hansen, Terese

    2015-08-01

    Extremely metal-poor (EMP) halo stars with [Fe/H] below ~ -3 are considered to be fossil records of conditions in the early halo. In the simplest picture where iron is a proxy for overall metallicity and indirectly for time, EMP stars formed before the oldest and most metal-poor Galactic globular clusters. High-resolution spectroscopy with 8m-class telescopes has shown the detailed abundance pattern of these stars to be surprisingly uniform (e.g. Bonifacio+ 2012) and essentially Solar, apart from the α-enhancement typical of SN II nucleosynthesis. A small fraction (~3%) of EMP stars, however, is strongly enhanced in the heaviest (r-process) neutron-capture elements, highlighting that the periodic system of elements was fully populated already this early.These striking departures from the general chemical homogeneity could be produced by local or distant sources. The former case is simple - mass transfer from a binary companion that evolved to produce a highly neutron-rich environment (one or more NS). Alternatively, the r-process elements were formed in a site at interstellar distance and preferentially seeded into the natal clouds of the present-day EMP-r stars. Our long-term, precise monitoring of the radial velocities of a sample of such stars (Hansen+ 2011) disproved the binary hypothesis, which would in fact also fail to explain the existence of r-process poor stars, such as HD 122653. We thus conclude that the chemical enrichment of the early halo was far more complex, patchy and likely anisotropic than assumed in current models of Galactic chemical evolution: The EMP-r stars are not just peculiarities to be ignored, but indicate that a new level of complexity must be invoked. That r-process elements have not (yet) been observed in high-redshift DLA systems is readily explained by their low abundance relative to the lighter species and the rarity of strong enrichment events.

  19. Mapping the transcription start points of the Staphylococcus aureus eap, emp, and vwb promoters reveals a conserved octanucleotide sequence that is essential for expression of these genes.

    Science.gov (United States)

    Harraghy, Niamh; Homerova, Dagmar; Herrmann, Mathias; Kormanec, Jan

    2008-01-01

    Mapping the transcription start points of the eap, emp, and vwb promoters revealed a conserved octanucleotide sequence (COS). Deleting this sequence abolished the expression of eap, emp, and vwb. However, electrophoretic mobility shift assays gave no evidence that this sequence was a binding site for SarA or SaeR, known regulators of eap and emp.

  20. An Approach for Effect Analysis of Electromagnetic Pulse in Operating NPPs

    Energy Technology Data Exchange (ETDEWEB)

    Ryu, Ho Sun; Ye, Song Hae; Kim, Minyi; Lee, Euijong [KHNP CRI, Daejeon (Korea, Republic of)

    2016-10-15

    Recently, there is a growing Electromagnetic Pulse (EMP) threat caused by North Korea’s nuclear weapons and unmanned aerial vehicles (UAVs). KHNP CRI is currently conducting a research project that will evaluate the safety of domestic nuclear power plants (NPPs) against EMP effects and prepare safety measures to counter vulnerable points. We will instead use simulation tools to evaluate the electromagnetic shielding ability and the conductivity of cables through vulnerable points in NPPs. Through a study of electromagnetic simulation techniques and tools, this paper suggests a simulation method for analysis of EMP effects in operating NPPs. Although 3D tools are relatively accurate, is difficult to use only 3D tools to simulate EMP effects for huge and complex structures such as NPPs. It is more efficient in terms of cost and time to use a 3D tool and an EMT tool for the simulation of such structures. We have compared the advantages and disadvantages of various methods and have selected the most appropriate tools; we will proceed in our next paper with the simulation of EMP effects.

  1. Analysis of gene expression profile induced by EMP-1 in esophageal cancer cells using cDNA Microarray

    Institute of Scientific and Technical Information of China (English)

    Hai-Tao Wang; Jian-Ping Kong; Fang Ding; Xiu-Qin Wang; Ming-Rong Wang; Lian-Xin Liu; Min Wu; Zhi-Hua Liu

    2003-01-01

    AIM: To obtain human esophageal cancer cell EC9706 stably expressed epithelial membrane protein-1 (EMP-1) with integrated eukaryotic plasmid harboring the open reading frame (ORF) of human EMP-1, and then to study the mechanism by which EMP-1 exerts its diverse cellular action on cell proliferation and altered gene profile by exploring the effect of EMP-1.METHODS: The authors first constructed pcDNA3.1/mychis expression vector harboring the ORF of EMP-1 and then transfected it into human esophageal carcinoma cell line EC9706. The positive clones were analyzed by Western blot and RT-PCR. Moreover, the cell growth curve was observed and the cell cycle was checked by FACS technique. Using cDNA microarray technology, the authors compared the gene expression pattern in positive clones with control. To confirm the gene expression profile, semi-quantitative RT-PCR was carried out for 4 of the randomly picked differentially expressed genes. For those differentially expressed genes,classification was performed according to their function and cellular component.RESULTS: Human EMP-1 gene can be stably expressed in ECg706 cell line transfected with human EMP-1. The authors found the cell growth decreased, among which S phase was arrested and G1 phase was prolonged in the transfected positive clones. By cDNA microarray analysis, 35 genes showed an over 2.0 fold change in expression level after transfection, with 28 genes being consistently up-regulated and 7 genes being down-regulated. Among the classified genes, almost half of the induced genes (13 out of 28 genes) were related to cell signaling, cell communication and particularly to adhesion.CONCLUSION: Overexpression of human EMP-1 gene can inhibit the proliferation of EC9706 cell with S phase arrested and G1 phase prolonged. The cDNA microarray analysis suggested that EMP-1 may be one of regulators involved incell signaling, cell communication and adhesion regulators.

  2. Effects of EMP Disturbance Parameters on Electronic Equipment Response%电路端口电磁脉冲响应影响参数分析

    Institute of Scientific and Technical Information of China (English)

    刘卫超; 魏明; 樊高辉; 吴启蒙

    2012-01-01

    To understand the response of the equipment under test (EUT) to electromagnetic pulse (EMP) and the relation of the response and the pulse disturbance, a pulse input experiment is conducted on an operational amplifier composed of two different operational amplifier chips. The effects of EMP parameters such as peak, rise time and fall time on the response are analyzed according to the experimental data. It is found that for a circuit with special function, same type of pulse but with different parameters induces different responses. An energy-coupling circuit model is established by using input and output data according to the artificial neural network (ANN) identification theory. The goodness of fit of the model can reach 88.4%, and it has a good generalization capability to qualitatively make response prediction.%为了探寻电子设备中的单元电路在电磁脉冲激励下的响应规律以及响应输出与输入脉冲干扰之间的关系,笔者选用两种不同型号的运算放大器集成芯片组成的仪表放大电路进行了脉冲注入实验.根据采集的实验数据,分析了脉宽、幅值等因素对响应输出的影响.通过对比发现:一定功能的电路,在同一类但不同参数的脉冲激励下,响应有所不同,且与各参数有一定的联系.根据基于人工神经网络的系统辨识理论,建立了能量耦合模型.经过自验证,其拟合度能够达到88.4%,且具有较好地泛化能力,能够定性地对电路做出响应预测.

  3. A influência da idade e da escolaridade sobre a experiência empática de adultos

    OpenAIRE

    Vanessa Dordron de Pinho; Conceição Santos Fernandes; Eliane Mary de Oliveira Falcone

    2011-01-01

    Atualmente, os teóricos começam a compartilhar uma visão da experiência empática humana como um fenômeno multidimensional influenciado por diversos aspectos, dentre eles, a idade e a escolaridade. No presente estudo, investigou-se as relações entre a habilidade social empática e essas duas variáveis sociodemográficas, em 537 participantes adultos. A habilidade empática foi estudada em quatro dimensões, que correspondem aos quatro fatores que compõem o instrumento utilizado, o Inventário de Em...

  4. Effect of Electromagnetic Pulse Exposure on Permeability of Blood-testicle Barrier in Mice

    Institute of Scientific and Technical Information of China (English)

    XIAO-WU WANG; GUI-RONG DING; CHANG-HONG SHI; TAO ZHAO; JIE ZHANG; LI-HUA ZENG; GUO-ZHEN GUO

    2008-01-01

    Objective To study the effect of electromagnetic pulse (EMP) exposure on the permeability of blood-testicle barrier (BTB) in mice. Methods Adult male BALB/c mice were exposed to EMP at 200 kV/m for 200 pulses with 2 seconds interval. The mice were injected with 2% Evans Blue solution through caudal vein at different time points after exposure, and the permeability of BTB was monitored using a fluorescence microscope. The testis sample for the transmission electron microscopy was prepared at 2 h after EMP exposure. The permeability of BTB in mice was observed by using Evans Blue tracer and lanthanum nitrate tracer. Results After exposure, cloudy Evans Blue was found in the testicle convoluted seminiferous tubule of mice. Lanthanum nitrate was observed not only between testicle spermatogonia near seminiferous tubule wall and sertoli cells, but also between sertofi cells and primary spermatocyte or secondary spermatocyte. In contrast,lanthanum nitrate in control group was only found in the testicle sertoli cells between seminiferous tubule and near seminiferous tubule wall. Conclusion EMP exposure could increase the permeability of BTB in the mice.

  5. Pulse Voltammetry.

    Science.gov (United States)

    Osteryoung, Janet

    1983-01-01

    Discusses the nature of pulse voltammetry, indicating that its widespread use arises from good sensitivity and detection limits and from ease of application and low cost. Provides analytical and mechanistic applications of the procedure. (JN)

  6. Exploring the SDSS Data Set with Linked Scatter Plots. I. EMP, CEMP, and CV Stars

    Science.gov (United States)

    Carbon, Duane F.; Henze, Christopher; Nelson, Bron C.

    2017-02-01

    We present the results of a search for extremely metal-poor (EMP), carbon-enhanced metal-poor (CEMP), and cataclysmic variable (CV) stars using a new exploration tool based on linked scatter plots (LSPs). Our approach is especially designed to work with very large spectrum data sets such as the SDSS, LAMOST, RAVE, and Gaia data sets, and it can be applied to stellar, galaxy, and quasar spectra. As a demonstration, we conduct our search using the SDSS DR10 data set. We first created a 3326-dimensional phase space containing nearly 2 billion measures of the strengths of over 1600 spectral features in 569,738 SDSS stars. These measures capture essentially all the stellar atomic and molecular species visible at the resolution of SDSS spectra. We show how LSPs can be used to quickly isolate and examine interesting portions of this phase space. To illustrate, we use LSPs coupled with cuts in selected portions of phase space to extract EMP stars, CEMP stars, and CV stars. We present identifications for 59 previously unrecognized candidate EMP stars and 11 previously unrecognized candidate CEMP stars. We also call attention to 2 candidate He ii emission CV stars found by the LSP approach that have not yet been discussed in the literature.

  7. Analysis of COPII Vesicles Indicates a Role for the Emp47-Ssp120 Complex in Transport of Cell Surface Glycoproteins.

    Science.gov (United States)

    Margulis, Neil G; Wilson, Joshua D; Bentivoglio, Christine M; Dhungel, Nripesh; Gitler, Aaron D; Barlowe, Charles

    2016-03-01

    Coat protein complex II (COPII) vesicle formation at the endoplasmic reticulum (ER) transports nascent secretory proteins forward to the Golgi complex. To further define the machinery that packages secretory cargo and targets vesicles to Golgi membranes, we performed a comprehensive proteomic analysis of purified COPII vesicles. In addition to previously known proteins, we identified new vesicle proteins including Coy1, Sly41 and Ssp120, which were efficiently packaged into COPII vesicles for trafficking between the ER and Golgi compartments. Further characterization of the putative calcium-binding Ssp120 protein revealed a tight association with Emp47 and in emp47Δ cells Ssp120 was mislocalized and secreted. Genetic analyses demonstrated that EMP47 and SSP120 display identical synthetic positive interactions with IRE1 and synthetic negative interactions with genes involved in cell wall assembly. Our findings support a model in which the Emp47-Ssp120 complex functions in transport of plasma membrane glycoproteins through the early secretory pathway.

  8. Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed

    DEFF Research Database (Denmark)

    Subramani, Ramesh; Quadt, Katharina; Jeppesen, Anine Engholm

    2015-01-01

    regardless of the PfEMP1 expressed. Our study documents for the first time that knob density is related to the PfEMP1 variant expressed. This may reflect topological requirements to ensure optimal adhesive properties of the IEs. IMPORTANCE: Infections with Plasmodium falciparum malaria parasites are still...... responsible for many deaths, especially among children and pregnant women. New interventions are needed to reduce severe illness and deaths caused by this malaria parasite. Thus, a better understanding of the mechanisms behind the pathogenesis is essential. A main reason why Plasmodium falciparum malaria......UNLABELLED: Members of the clonally variant Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediate adhesion of infected erythrocytes (IEs) to vascular receptors. PfEMP1 expression is normally confined to nanoscale knob protrusions on the IE surface membrane. To investigate...

  9. Plasmodium falciparum-Infected Erythrocyte Knob Density Is Linked to the PfEMP1 Variant Expressed

    DEFF Research Database (Denmark)

    Subramani, Ramesh; Quadt, Katharina; Jeppesen, Anine Engholm;

    2015-01-01

    UNLABELLED: Members of the clonally variant Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediate adhesion of infected erythrocytes (IEs) to vascular receptors. PfEMP1 expression is normally confined to nanoscale knob protrusions on the IE surface membrane. To investigate...... regardless of the PfEMP1 expressed. Our study documents for the first time that knob density is related to the PfEMP1 variant expressed. This may reflect topological requirements to ensure optimal adhesive properties of the IEs. IMPORTANCE: Infections with Plasmodium falciparum malaria parasites are still...... responsible for many deaths, especially among children and pregnant women. New interventions are needed to reduce severe illness and deaths caused by this malaria parasite. Thus, a better understanding of the mechanisms behind the pathogenesis is essential. A main reason why Plasmodium falciparum malaria...

  10. A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytes

    DEFF Research Database (Denmark)

    Bengtsson, Dominique; Sowa, Kordai M; Salanti, Ali;

    2008-01-01

    BACKGROUND: The insertion of parasite antigens into the host erythrocyte membrane and the structure and distribution of Plasmodium falciparum adhesion receptors on that membrane are poorly understood. Laser scanning confocal microscopy (LSCM) and a novel labelling and fixation method have been used...... to obtain high resolution immuno-fluorescent images of erythrocyte surface PfEMP1 and internal antigens which allow analysis of the accumulation of PfEMP1 on the erythrocyte membrane during asexual development. METHODS: A novel staining technique has been developed which permits distinction between...... erythrocyte surface PfEMP1 and intracellular PfEMP1, in parasites whose nuclear material is exceptionally well resolved. Primary antibody detection by fluorescence is carried out on the live parasitized erythrocyte. The surface labelled cells are then fixed using paraformaldehyde and permeabilized with a non...

  11. 复合材料雷体的UWB-EMP耦合效应研究%Coupling effect of UWB-EMP on landmine shell made with composite materials

    Institute of Scientific and Technical Information of China (English)

    高振儒; 方向; 赵惠昌; 易韵; 李德林

    2014-01-01

    In view of the serious threats of high power microwave ( HPM ) mine sweepers to modern landmines,in order to improve the capability of landmines against electromagnetic damage, a new kind of landmine shell made with composite materials is studied using stainless steel fibers( SSF) to fill polyamide resin. Based on the shell structure and setting pose of landmines, the slot coupling effect of ultra-wide band electromagnetic pulse( UWB-EMP) on landmine shell is analyzed by finite difference time domain ( FDTD ) numerical calculation. Landmine shell samples are prepared with composite materials. When electronical fuzes connected with electrical fire head are fit under the shell in the microwave anechoic chamber, experiments of damage effect of UWB electromagnetic pulse radiation with peak power of 1 GW are conducted. When the distance between shell and antenna is more than 50 cm,the fuze in the shell can work normally. The results show the shells can promote the viability of landmines with electronical fuzes against strong electromagnetic damage in high power electromagnetic environment.%针对高功率微波( High power microwave,HPM)扫雷装置对现代地雷构成的严重威胁,为提高地雷抗电磁毁伤能力,将不锈钢纤维( Stainless steel fibers,SSF)作为聚酰胺树脂的导电填料,研究新型复合屏蔽材料地雷壳体。针对雷体结构和布设状态,采用时域有限差分( Finite difference time domain, FDTD )数值方法,分析该壳体的超宽带电磁脉冲( Ultra-wide band electromagnetic pulse,UWB-EMP)孔缝耦合规律。加工复合材料地雷壳体样品,内置电子引信并连接电引火头,在微波暗室进行峰值功率1 GW的UWB-EMP辐照下的效应实验,壳体放置天线前的距离大于0.5 m时,内部电子引信能正常工作。结果表明:该壳体能有效提高电子引信地雷抗强电磁毁伤等复杂战场电磁环境下的生存能力。

  12. Differential diagnosis of acute rejection and chronic cyclosporine nephropathy after rat renal transplantation by detection of endothelial microparticles (EMP).

    Science.gov (United States)

    Cui, Jiewei; Yang, Jing; Cao, Weike; Sun, Yi

    2010-12-01

    Endothelial microparticles (EMP) are small vesicles smaller than 1.0μm, released from endothelial cells (EC) during their activation and (or) apoptosis. The assay of the level of elevated EMP is a new approach to evaluate the dysfunction of endothelial cell. EMP can be classified into several types according to their membrane molecular, and the levels of various types of EMP may be different. As the most cost-effective immunodepressant, cyclosporine A (CsA) has been used widely in organ transplantation. But its dose is hard to control, under-medication may cause the acute rejection (AR) and overdose may cause chronic cyclosporine nephropathy (CCN). The cyclosporine A (CsA) caused CCN and the AR caused renal injury after renal transplantation are both vascular diseases related with endothelial dysfunction, and up to now, there is still no effective method to distinguish the two kinds of diseases. Owing to distinct pathogenesis of the two kinds of vascular diseases, the level of each type of EMP originated from vascular endothelial cells may be different. We hypothesize that maybe we can distinguish them by detecting the different levels of some types of EMP which is also related with vascular disease, and we propose to prove our hypothesis through animal experiment. If our hypothesis is proved, it will be more helpful for clinicians to adjust the dose of CsA promptly according to the differential diagnosis of the two kinds of diseases.

  13. Restrain of bone growth by estrogen-mimetic peptide-1 (EMP-1): a micro-computed tomographic study.

    Science.gov (United States)

    Kasher, Roni; Bajayo, Alon; Gabet, Yankel; Nevo, Nava; Fridkin, Mati; Katchalski-Katzir, Ephraim; Kohen, Fortune; Bab, Itai

    2009-06-01

    Estrogen has a key role in the regulation of skeletal growth and maintenance of bone mass. Recently, we developed peptides having estrogen-like activity as potential estrogen-based new drugs. The aim of the present study was to evaluate the influence of long-term administration of the most efficacious of these peptides, the hexapeptide EMP-1 (VSWFFE), on bone mass and development. EMP-1 was injected daily to ovariectomized (OVX) and intact young, sexually mature female mice for 10 weeks. Whole femora, including the cartilaginous growth plates were analyzed by micro-computed tomography (microCT). We found that peptide EMP-1 restrains bone growth in OVX mice: it inhibited dramatically bone longitudinal growth (40%), and decreased femoral diaphyseal diameter. Peptide EMP-1 had no effect on bone growth in normal mice, and did not influence the OVX-induced bone loss. We then developed a new microCT methodology to evaluate uncalcified and calcified growth plate parameters. In the OVX mice, peptide EMP-1 reduced volume and thickness of the uncalcified growth plate, a possible cause for the inhibition of bone longitudinal growth. Peptide EMP-1 may be used as a lead compound for the development of drugs to treat acromegalic patients.

  14. Report of the Commission to Assess the Threat to the United States from Electromagnetic Pulse (EMP) Attack: Critical National Infrastructures

    Science.gov (United States)

    2008-04-01

    important avenue for intercontinental com- merce today. The 18th century saw the rise of canals in the eastern states, and interest in them lasted...through the first decades of the 19th century. Later the railroad supplanted canals in the east and opened the western territories for large-scale...filters and screens must be backwashed regularly. Disinfection uses chemicals to kill any microorganisms that may have survived the fil - tration

  15. Pulse plating

    CERN Document Server

    Hansal, Wolfgang E G; Green, Todd; Leisner, Peter; Reichenbach, Andreas

    2012-01-01

    The electrodeposition of metals using pulsed current has achieved practical importance in recent years. Although it has long been known that changes in potential, with or without polarity reversal, can significantly affect the deposition process, the practical application of this has been slow to be adopted. This can largely be explained in terms of the complex relationship between the current regime and its effect on the electrodeposition process. In order to harness these effects, an understanding of the anodic and cathodic electrochemical processes is necessary, together with the effects of polarity reversal and the rate of such reversals. In this new monograph, the basics of metal electrodeposition from solution are laid out in great detail in seven distinct chapters. With this knowledge, the reader is able to predict how a given pulse train profile can be adopted to achieve a desired outcome. Equally important is the choice of a suitable rectifier and the ancillary control circuits to enable pulse platin...

  16. Preventing Electromagnetic Pulse Irradiation Damage on Testis Using Selenium-rich Cordyceps Fungi. A Preclinical Study in Young Male Mice.

    Science.gov (United States)

    Miao, Xia; Wang, Yafeng; Lang, Haiyang; Lin, Yanyun; Guo, Qiyan; Yang, Mingjuan; Guo, Juan; Zhang, Yanjun; Zhang, Jie; Liu, Junye; Liu, Yaning; Zeng, Lihua; Guo, Guozhen

    2017-02-01

    Networked 21st century society, globalization, and communications technologies are paralleled by the rise of electromagnetic energy intensity in our environments and the growing pressure of the environtome on human biology and health. The latter is the entire complement of environmental factors, including the electromagnetic energy and the technologies that generate them, enacting on the digital citizen in the new century. Electromagnetic pulse (EMP) irradiation might have serious damaging effects not only on electronic equipment but also in the whole organism and reproductive health, through nonthermal effects and oxidative stress. We sought to determine whether EMP exposure (1) induces biological damage on reproductive health and (2) the extent to which selenium-rich Cordyceps fungi (daily coadministration) offer protection on the testicles and spermatozoa. In a preclinical randomized study, 3-week-old male BALB/c mice were repeatedly exposed to EMP (peak intensity 200 kV/m, pulse edge 3.5 ns, pulse width 15 ns, 0.1 Hz, and 400 pulses/day) 5 days per week for four consecutive weeks, with or without coadministration of daily selenium-rich Cordyceps fungi (100 mg/kg). Testicular index and spermatozoa formation were measured at baseline and 1, 7, 14, 28, and 60 day time points after EMP exposure. The group without Cordyceps cotreatment displayed decreased spermatozoa formation, shrunk seminiferous tubule diameters, and diminished antioxidative capacity at 28 and 60 days after exposure (p < 0.05). The Cordyceps daily cotreatment alleviated the testicular damage by EMP exposure, increased spermatozoa formation, and reduced apoptotic spermatogenic cells. These observations warrant further preclinical and clinical studies as an innovative approach for potential protection against electromagnetic radiation in the current age of networked society and digital citizenship.

  17. Numerical simulation of narrow bipolar electromagnetic pulses generated by thunderstorm discharges

    Science.gov (United States)

    Bochkov, E. I.; Babich, L. P.; Kutsyk, I. M.

    2013-07-01

    Using the concept of avalanche relativistic runaway electrons (REs), we perform numerical simulations of compact intracloud discharge (CID) as a generator of powerful natural electromagnetic pulses (EMPs) in the HF-VHF range, called narrow bipolar pulses (NBPs). For several values of the field overvoltage and altitude at which the discharge develops, the numbers of seed electrons initiating the avalanche are evaluated, with which the calculated EMP characteristics are consistent with the measured NBP parameters. We note shortcomings in the hypothesis assuming participation of cosmic ray air showers in avalanche initiation. The discharge capable of generating NBPs produces REs in numbers close to those in the source of terrestrial γ-ray flashes (TGFs), which can be an argument in favor of a unified NBP and TGF source.

  18. Numerical simulation of narrow bipolar electromagnetic pulses generated by thunderstorm discharges

    Energy Technology Data Exchange (ETDEWEB)

    Bochkov, E. I.; Babich, L. P., E-mail: babich@elph.vniief.ru; Kutsyk, I. M. [All-Russia Research Institute of Experimental Physics, Russian Federal Nuclear Center (Russian Federation)

    2013-07-15

    Using the concept of avalanche relativistic runaway electrons (REs), we perform numerical simulations of compact intracloud discharge (CID) as a generator of powerful natural electromagnetic pulses (EMPs) in the HF-VHF range, called narrow bipolar pulses (NBPs). For several values of the field overvoltage and altitude at which the discharge develops, the numbers of seed electrons initiating the avalanche are evaluated, with which the calculated EMP characteristics are consistent with the measured NBP parameters. We note shortcomings in the hypothesis assuming participation of cosmic ray air showers in avalanche initiation. The discharge capable of generating NBPs produces REs in numbers close to those in the source of terrestrial {gamma}-ray flashes (TGFs), which can be an argument in favor of a unified NBP and TGF source.

  19. Long-term electromagnetic pulse exposure induces Abeta deposition and cognitive dysfunction through oxidative stress and overexpression of APP and BACE1.

    Science.gov (United States)

    Jiang, Da-Peng; Li, Jin-Hui; Zhang, Jie; Xu, Sheng-Long; Kuang, Fang; Lang, Hai-Yang; Wang, Ya-Feng; An, Guang-Zhou; Li, Jing; Guo, Guo-Zhen

    2016-07-01

    A progressively expanded literature has been devoted in the past years to the noxious or beneficial effects of electromagnetic field (EMF) to Alzheimer׳s disease (AD). This study concerns the relationship between electromagnetic pulse (EMP) exposure and the occurrence of AD in rats and the underlying mechanisms, focusing on the role of oxidative stress (OS). 55 healthy male Sprague Dawley (SD) rats were used and received continuous exposure for 8 months. Morris water maze (MWM) test was conducted to test the ability of cognitive and memory. The level of OS was detected by superoxide dismutase (SOD) activity and glutathione (GSH) content. We found that long-term EMP exposure induced cognitive damage in rats. The content of β-amyloid (Aβ) protein in hippocampus was increased after long-term EMP exposure. OS of hippocampal neuron was detected. Western blotting and immunohistochemistry (IHC) assay showed that the content of Aβ protein and its oligomers in EMP-exposed rats were higher than that of sham-exposed rats. The content of Beta Site App Cleaving Enzyme (BACE1) and microtubule-associated protein 1 light chain 3-II (LC3-II) in EMP-exposed rats hippocampus were also higher than that of sham-exposed rats. SOD activity and GSH content in EMP-exposed rats were lower than sham-exposed rats (pEMP exposure-induced OS, including increased amyloid precursor protein (APP) aberrant cleavage. Although further study is needed, the present results suggest that long-term EMP exposure is harmful to cognitive ability in rats and could induce AD-like pathological manifestation.

  20. Electromagnetic Pulse Weapons as an Emergent Technology and Their Place on Battlefields of the Future

    Science.gov (United States)

    2010-04-19

    relationship of target’s hardening with respect to the generated electromagnetic pulse strength, electromagnetic atmospherics, and the electronic...Here targeting analysis becomes marked more complex and needs to encompass neighboring population centers which may be codependent on power or water...How is there relationship here at all? At first glance, it may seem absurd to consider an EMP a weapon of mass destruction. If improperly employed

  1. Measurement of electromagnetic pulses generated during interactions of high power lasers with solid targets

    Science.gov (United States)

    De Marco, M.; Krása, J.; Cikhardt, J.; Pfeifer, M.; Krouský, E.; Margarone, D.; Ahmed, H.; Borghesi, M.; Kar, S.; Giuffrida, L.; Vrana, R.; Velyhan, A.; Limpouch, J.; Korn, G.; Weber, S.; Velardi, L.; Delle Side, D.; Nassisi, V.; Ullschmied, J.

    2016-06-01

    A target irradiated with a high power laser pulse, blows off a large amount of charge and as a consequence the target itself becomes a generator of electromagnetic pulses (EMP) owing to high return current flowing to the ground through the target holder. The first measurement of the magnetic field induced by the neutralizing current reaching a value of a few kA was performed with the use of an inductive target probe at the PALS Laser Facility (Cikhardt et al. Rev. Sci. Instrum. 85 (2014) 103507). A full description of EMP generation should contain information on the spatial distribution and temporal variation of the electromagnetic field inside and outside of the interaction chamber. For this reason, we consider the interaction chamber as a resonant cavity in which different modes of EMP oscillate for hundreds of nanoseconds, until the EMP is transmitted outside through the glass windows and EM waves are attenuated. Since the experimental determination of the electromagnetic field distribution is limited by the number of employed antennas, a mapping of the electromagnetic field has to be integrated with numerical simulations. Thus, this work reports on a detailed numerical mapping of the electromagnetic field inside the interaction chamber at the PALS Laser Facility (covering a frequency spectrum from 100 MHz to 3 GHz) using the commercial code COMSOL Multiphysics 5.2. Moreover we carried out a comparison of the EMP generated in the parallelepiped-like interaction chamber used in the Vulcan Petawatt Laser Facility at the Rutherford Appleton Laboratory, against that produced in the spherical interaction chamber of PALS.

  2. Characteristics of Electromagnetic Pulse Coupling into Annular Apertures

    Directory of Open Access Journals (Sweden)

    Yan-Peng Sun

    2013-11-01

    Full Text Available Electromagnetic pulse (EMP coupling into the annular apertures can disturb or damage much electronic equipment. To enhance electronic system’s  capability of anti-electromagnetic interference, the finite difference time domain method (FDTD was employed to study the characteristics of electromagnetic pulse coupling into the cavity enclosures with annular apertures. The coupling characteristics of annular apertures with different shapes (rectangle, square and circle were discussed. It shows that, in the case of the same aperture area, the coupling energy of electromagnetic pulse into the circular annular aperture is smaller than that into the rectangular and the square ones. To the rectangular annular aperture, while the polarization direction of the incident electromagnetic pulse is perpendicular to the long side of the rectangular annular aperture, the coupling energy is larger when the aspect ratio of the rectangular annular aperture is larger. The coupling effect of incident pulse with short pulse width is obviously better than the one with longer pulse width. The resonance phenomenon of the coupled waveform occurs in the cavity.

  3. PERANAN HOME INDUSTRI EMPING MELINJO DALAM MENINGKATKAN PENDAPATAN KELUARGA DI KECAMATAN BURNEH KABUPATEN BANGKALAN

    Directory of Open Access Journals (Sweden)

    Yusrianto Sholeh

    2017-04-01

    Full Text Available ABSTRAKPenelitian ini bertujuan untuk mengetahui hal-hal sebagai berikut: (1 Untuk mengetahui pendapatan tenaga tenaga kerja Industri Emping Melinjo di Kecamatan Burneh Kabupaten Bangkalan, (2 Untuk mengetahui kontribusi pendapatan tenaga kerja terhadap pendapatan keluarga di sektor industri Emping Melinjo di Kecamatan Burneh Kabupaten Bangkalan. Hasil penelitian menunjukkan bahwa pendapatan keluarga di Kecamatan Burneh Kabupaten Bangkalan (Dengan jumlah pendapatan terkecil yaitu 38 orang atau 44% yaitu Rp 750.000-Rp 1.100.000. Kemudian pada jumlah pendapatan terbesar yang diperoleh tenaga kerja ialah Rp.2.150.000-Rp.2.500.000 berjumlah 2 orang atau 2%. Sedangkan kontribusi terhadap pendapatan di sektor industri Emping Melinjo di Kecamatan Burneh Kabupaten Bangkalan bahwa kontribusi pendapatan keluarga terbesar/Tinggi  sebanyak 24 orang atau 28 %, kemudian  nilai yang terkecil/sangat rendah ialah 10 orang atau 11 %.HOME INDUSTRY MELINJO ROLE IN IMPROVING INCOME FAMILIES IN THE DISTRICT DISTRICT BURNEH BANGKALANABSTRACTThis study aims to determine the following matters: (1 to determine the earnings of industrialworkers in the district chips melinjo Burneh Bangkalan district. (2 to determine the contribution of labor income to the family income in theindustrial sectorin the sub chips melinjo Burneh Bangkalan district.the result showed that the income of families in the district (with the smallest amount of income that is 38 or 44% is Rp 750.000-Rp 1.100.000, then the largest amount of income earned is labor Rp.2.150.000-2.500.000 amounted to 2 or 2%.While the contribution to earning in the industrial sector in the sub chips melinjo Burneh Bangkalan district that contributes the largest family incomeas many as 24 people or 28%, then the smallest value is 10 or 11%

  4. Empowerment impact assessment (EmpIA), a tool for poverty alleviation and capacity building

    CSIR Research Space (South Africa)

    Louw, MR

    2006-09-01

    Full Text Available : “Project specifications will provide minimum targets for employment of local labour and for training of labour and ABEs.” “Design specifications and contract documentation will be such to maximise the impact on empowerment.” 1.2 EmpIA and other...), the tendency is for the entire unemployed and under- employed segment to be attracted to the opportunities presented by the project (assuming the wage rate is < or = to the average wage in the area), instead of those with a genuine interest in the industry...

  5. Contraste empírico del CAPM en el mercado accionario chileno

    OpenAIRE

    Carlos A Díaz Contreras; Freddy H Higuera Cartes

    2012-01-01

    El modelo de valoración de activos de capital (Capital Asset Pricing Model - CAPM) es uno de los modelos más utilizados en la práctica para determinar el premio por riesgo de un activo individual o cartera. El presente trabajo realiza un contraste empírico del CAPM en el mercado accionario chileno, empleando las metodologías de serie temporal y de eficiencia media-varianza, basada en la estimación por el método generalizado de momentos (MGM). El contraste se llevó a cabo usando rentabilidades...

  6. Una Evaluación Empírica del Fondo de Comercio

    OpenAIRE

    Manuel Larrán Jorge; Juan Monterrey Mayoral; Eva Mulero Mendigorri

    2000-01-01

    En el presente trabajo se analizará bajo una perspectiva empírica uno de los activos empresariales más controvertidos como es el fondo de comercio. Dicha controversia no se materializa únicamente en su definición, sino también en su cuantificación y tratamiento contable, dando lugar en los últimos años a una importante línea de investigación centrada en la relevancia valorativa del fondo de comercio en particular y de los intangibles en general. Nuestro trabajo plantea un doble objetivo: en p...

  7. Evidencia empírica sobre la paridad del poder adquisitivo en México

    OpenAIRE

    Lorena Medina; Noriega, Antonio E.

    2001-01-01

    En este artículo se describe la aplicación de métodos recientes para probar la estacionariedad del tipo de cambio real peso/dólar, tomando en cuenta la presencia de un número desconocido de cambios estructurales en el nivel de largo plazo de la serie. En nuestra implementación empírica, la inferencia se basa en valores críticos fundamentados en técnicas de remuestreo. Se presenta evidencia contundente sobre la estacionariedad del tipo de cambio real, apoyando así la hipótesis de la paridad de...

  8. Analysis of threat coming from EMP to RF receiver%电磁脉冲对射频接收机威胁分析

    Institute of Scientific and Technical Information of China (English)

    郭力闻; 张占月; 张喆

    2015-01-01

    射频接收机是现代电子系统中最重要的组成部分,应用在通信、导航等许多领域。射频接收机一般位于天线后端,直接发送和接收空间中的各种电磁信息。然而,由于接收机可以接收到任何信息,因此它也极易被干扰,如高功率噪声和电磁脉冲。首先分析了电子设备的电磁环境,然后主要以射频接收机为对象,将电子系统模块化建模,分析在空间环境中遭遇电磁脉冲攻击时的受损情况,最后通过系统建模仿真,分析了电磁脉冲对射频接收机后端系统的损坏情况。%RF receiver is the most important part of modern electronic system,and widely applied in communication,navi⁃gation and other fields. Generally the RF receiver is located in the back⁃end of the antenna,and used to send and receive a variety of electromagnetic information in the space directly. Since the receiver can receive any information,it is also vulnerable to the interference,such as high power noise and electromagnetic pulse (EMP). The electromagnetic environment of electronic equip⁃ment is analyzed,then taking the RF receiver as the main object,and the electronic system is conducted with modular modeling. The damaged condition of the receiver attacked by EMP in the space environment is analyzed. The damaged condition coming from electromagnetic pulse to the back⁃end system of the RF receiver is analyzed by system modeling and simulation.

  9. Pulsed thermoelectricity

    Science.gov (United States)

    Apostol, M.; Nedelcu, M.

    2010-07-01

    A special mechanism of thermoelectric transport is described, consisting of pulses of charge carriers which "fly" periodically through the external circuit from the hot end of the sample to the cold end, with a determined duration of the "on" and "off" times of the electric contacts, while maintaining continuously the thermal contacts. It is shown that such a "resonant" ideal thermogenerator may work cyclically, with the same efficiency quotient as the ideal efficiency quotient of the thermoelectric devices operated in the usual stationary transport regime but the electric flow and power are increased, as a consequence of the concentration of the charge carriers on pulses of small spatial extent. The process is reversible, in the sense that it can be operated either as a thermoelectric generator or as an electrothermal cooler.

  10. Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed

    DEFF Research Database (Denmark)

    Subramani, Ramesh; Quadt, Katharina; Jeppesen, Anine Engholm;

    2015-01-01

    UNLABELLED: Members of the clonally variant Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediate adhesion of infected erythrocytes (IEs) to vascular receptors. PfEMP1 expression is normally confined to nanoscale knob protrusions on the IE surface membrane. To investigate...... the relationship between the densities of these IE surface knobs and the PfEMP1 variant expressed, we used specific antibody panning to generate three sublines of the P. falciparum clone IT4, which expresses the PfEMP1 variants IT4VAR04, IT4VAR32b, and IT4VAR60. The knob density in each subline was then determined...... by atomic force microscopy (AFM) and scanning electron microscopy (SEM) and compared to PfEMP1 and knob-associated histidine-rich protein (KAHRP) expression. Selection for uniform expression of IT4VAR04 produced little change in knob density, compared to unselected IEs. In contrast, selection for IT4VAR32b...

  11. Numerical simulation of the coupling of ultra-wide band electromagnetic pulse into landmine by aperture

    Science.gov (United States)

    Gao, Zhen-Ru; Zhao, Hui-Chang; Yang, Li; Wang, Feng-Shan

    2015-09-01

    The modern landmine’s electronic fuse is susceptible to strong interference or can even be damaged by the ultra-wide band electromagnetic pulse (UWB-EMP). The finite-difference time-domain (FDTD) method in lossy media with cylindrical coordinates is used to study the interactions of the UWB-EMP with the landmine. First, the coupling of UWB-EMP into the landmine shielding shell through an aperture is numerically simulated. Second, the coupled electromagnetic field of mine shells made of different shielding materials and with apertures of different sizes is plotted. Third, the aperture coupling laws of UWB-EMP into shells are analyzed and categorized. Such an algorithm is capable of effectively preventing ladder similar errors, and consequently improving the calculation precision, and in addition to adopting the message passing interface (MPI) parallel method to divide the total calculating range into more sub-ranges, the overall calculating efficiency is greatly increased. These calculations are surely a constructive reference for modern landmine design against electromagnetic damage. Project supported by the Postdoctoral Science Foundation of China (Grant No. 2014M552610).

  12. A economia da sonegação: teorias e evidências empíricas The economics of tax evasion: theories and emprirical evidences

    Directory of Open Access Journals (Sweden)

    Marcelo Lettieri Siqueira

    2005-12-01

    Full Text Available Este artigo fornece uma visão geral da literatura teórica e empírica, nacional e internacional, acerca do estudo econômico da sonegação de impostos. Após apresentar uma definição da sonegação fiscal, em confronto com a elisão fiscal, e analisar a questão da mensuração da sonegação, discutimos o modelo básico de análise da sonegação fiscal de Allingham e Sandmo (1972, apresentamos uma revisão de suas numerosas extensões, avaliamos os efeitos da política de imposição tributária sobre a decisão de sonegar e, por fim, examinamos as evidências empíricas acerca do comportamento do contribuinte e dos níveis de sonegação gerados por ele.This paper provides an overview of the findings of the theoretical and empirical literature on tax evasion. After we define tax evasion, as opposed to tax avoidance, and analyze the question of the tax evasion measurement, we discuss the Allingham and Sandmo's basic model on tax evasion, with a brief review of its numerous extensions, we deal with the effects of tax enforcement policy on the decision to evade taxes, and, finally, we survey the empirical evidence on taxpayer compliance and the tax gap produced for the taxpayer behavior.

  13. EMP Attachment 3 DOE-SC PNNL Site Dose Assessment Guidance

    Energy Technology Data Exchange (ETDEWEB)

    Snyder, Sandra F.

    2011-12-21

    This Dose Assessment Guidance (DAG) describes methods to use to determine the Maximally-Exposed Individual (MEI) location and to estimate dose impact to that individual under the U.S. Department of Energy Office of Science (DOE-SC) Pacific Northwest National Laboratory (PNNL) Site Environmental Monitoring Plan (EMP). This guidance applies to public dose from radioactive material releases to the air from PNNL Site operations. This document is an attachment to the Pacific Northwest National Laboratory (PNNL) Environmental Monitoring Plan (EMP) and describes dose assessment guidance for radiological air emissions. The impact of radiological air emissions from the U.S. Department of Energy Office of Science (DOE-SC) PNNL Site is indicated by dose estimates to a maximally exposed member of the public, referred to as the maximally exposed individual (MEI). Reporting requirements associated with dose to members of the public from radiological air emissions are in 40 CFR Part 61.94, WAC 246-247-080, and DOE Order 458.1. The DOE Order and state standards for dose from radioactive air emissions are consistent with U.S. Environmental Protection Agency (EPA) dose standards in 40 CFR 61.92 (i.e., 10 mrem/yr to a MEI). Despite the fact that the current Contract Requirements Document (CRD) for the DOE-SC PNNL Site operations does not include the requirement to meet DOE CRD 458.1, paragraph 2.b, public dose limits, the DOE dose limits would be met when EPA limits are met.

  14. Comercio, empleo y salarios en Colombia: Teoría y evidencia empírica

    Directory of Open Access Journals (Sweden)

    De Lombaerde Philippe

    2002-08-01

    Full Text Available El autor parte de la observación de que el debate academico sobre la apertura en Colombia es un debate demasiado polarizado, y sostiene que se requiere una combinación de teorías y de enfoques para poder analizar el tema, y un mayor enfasis en el análisis empírico. Con base en un análisis de la evidencia disponible hasta el momento, llega a las siguientes conclusiones; ies la combinación de la políticas de apertura, por un lado, y las tendencias en materia de cambio tecnologico y de cambio a nivel de los facotres de producción, por otro que explica el comportamiento de las variables comerciales, laborales y de producción; iiaunque ciertos flujos comerciales responden a la logica de los modelos clasicos y neoclasicos, la aperura en su conjunto no se captan en ellos; iiien cuanto a la formulacion de politicas industriales y comerciales alternativas, deben sustentarse teórica y empíricamente, y deben estar acompañadas por un analisis detallado de los costos y beneficios económicos, y sociales y de los efectos redistributivos; ivno hay duda de que la apertura este relacionada con los efectos adversos en el empleo y los salarios de los 90's.

  15. First Stars XIV. Sulphur abundances in extremely metal-poor (EMP) stars

    CERN Document Server

    Spite, Monique; Andrievsky, S M; Korotin, S A; Depagne, E; Spite, F; Bonifacio, P; Ludwig, H -G; Cayrel, R; Francois, P; Hill, V; Plez, B; Andersen, J; Barbuy, B; Beers, T C; Molaro, P; Nordstrom, B; Primas, F

    2010-01-01

    Sulphur is important: the site of its formation is uncertain, and at very low metallicity the trend of [S/Fe] against [Fe/H] is controversial. Below [Fe/H]=-2.0, [S/Fe] remains constant or it decreases with [Fe/H], depending on the author and the multiplet used in the analysis. Moreover, although sulphur is not significantly bound in dust grains in the ISM, it seems to behave differently in DLAs and in old metal-poor stars. We aim to determine precise S abundance in a sample of extremely metal-poor stars taking into account NLTE and 3D effects. NLTE profiles of the lines of the multiplet 1 of SI have been computed using a new model atom for S. We find sulphur in EMP stars to behave like the other alpha-elements, with [S/Fe] remaining approximately constant below [Fe/H]=-3. However, [S/Mg] seems to decrease slightly as a function of [Mg/H]. The overall abundance patterns of O, Na, Mg, Al, S, and K are best matched by the SN model yields by Heger & Woosley. The [S/Zn] ratio in EMP stars is solar, as found a...

  16. Empédocles entre Mýthos e Lógos : um estudo sobre a relação entre os poemas de Empédocles depois do Papiro de Estrasburgo

    OpenAIRE

    Leão, Eryc de Oliveira

    2013-01-01

    Essa dissertação de mestrado tem como objetivo principal fornecer evidências de ordem filosófica, sociológica, filológica e historiográfica, para o fato da unidade temática dos dois poemas de Empédocles, intitulados “Sobre a Natureza” e “Purificações”. Tal fato encontra-se registrado na evidência direta do texto de Empédocles conhecido como Papiro de Estrasburgo, publicado por Martin-Primavesi (1999). Para ficar apenas com o exemplo mais importante, no conjunto d do Papiro de Estrasburgo...

  17. La ilusión científica en la macroeconomía empírica

    Directory of Open Access Journals (Sweden)

    Summers Lawrence H.

    1995-12-01

    Full Text Available Muchos macroeconomistas y la mayoría de los econometristas creen y enseñan a sus estudiantes que 1 el trabajo empírico en macroeconomía debe dedicarse a identificar los ‘parámetros estructurales básicos’ que representan las preferencias y la tecnología; 2 el mejor trabajo empírico en macroeconomía prueba formalmente las hipótesis esenciales derivadas rigurosamente de la teoría económica; 3 las técnicas estadísticas sofisticadas pueden jugar un papel importante para determinar la causación en sistemas con muchas variables independientes. Estas creencias constituyen el núcleo de los que yo llamo la ilusión científica en la macroeconomía empírica.

  18. Necessity of re-evaluation of estramustine phosphate sodium (EMP) as a treatment option for first-line monotherapy in advanced prostate cancer.

    Science.gov (United States)

    Kitamura, T

    2001-02-01

    Estramustine phosphate sodium (EMP) was first introduced in the early 1970s for the treatment of prostate cancer, when EMP was supposed to have the dual effect of estrogenic activity and cytotoxicity. For the following decades, it was used mainly in hormone-refractory cases, with a conventional dosage of 4-9 capsules/day, which showed a 30-35% objective response rate. However, a very limited number of cases have been reported that used EMP as a first-line monotherapy in the conventional dosage. One study showed a response rate of 82%, which is at least as effective as conventional estrogen (diethylstilbestrol; DES) monotherapy. Nevertheless, EMP was almost abandoned for the treatment of prostate cancer because of severe adverse side-effects, especially in the cardiovascular system and gastrointestinal tract. Recently, two facts have become evident. First, EMP interferes with cellular microtubule dynamics but does not show alkylating effects. Second, EMP is able to produce a complex with calcium when dairy products are taken concomitantly with EMP, resulting in a decrease in the absorption rate of EMP from the gut. Many clinical trials have been undertaken without warning against concomitant dairy product intake since the introduction of EMP. This fact will jeopardize almost all the clinical trials performed before 1990. It is considered that response rates have been underestimated and better results could have been obtained because side-effects decrease dose-dependently. Low-dose EMP monotherapy (2 capsules/day) has been performed infrequently in previously untreated advanced prostate cancer. The only large trial by the European Organization for Research and Treatment of Cancer in 1984 was biased in selecting patients. Nevertheless, the response rate of EMP is comparable to that of DES. In this study, the adverse side-effects of EMP were less than that of DES. Recently, a study was conducted at the University of Tokyo of 11 patients with advanced prostate cancer on

  19. PULSE COLUMN

    Science.gov (United States)

    Grimmett, E.S.

    1964-01-01

    This patent covers a continuous countercurrent liquidsolids contactor column having a number of contactor states each comprising a perforated plate, a layer of balls, and a downcomer tube; a liquid-pulsing piston; and a solids discharger formed of a conical section at the bottom of the column, and a tubular extension on the lowest downcomer terminating in the conical section. Between the conical section and the downcomer extension is formed a small annular opening, through which solids fall coming through the perforated plate of the lowest contactor stage. This annular opening is small enough that the pressure drop thereacross is greater than the pressure drop upward through the lowest contactor stage. (AEC)

  20. Hemiparesia esquerda consecutiva a empeçonhamento: Por Bothrops Jararacussu

    Directory of Open Access Journals (Sweden)

    Napoleão L. Teixeira

    1944-09-01

    Full Text Available O A. apresenta uma observação de hemiparesia esquerda, consecutiva a envenenamento por Bothrops Jararacussu. É o segundo caso que publica, com idêntica etiologia; além das suas, há duas outras observações semelhantes, de Octávio de Magalhães. Depois de discorrer sobre as hemiplegias cerebrais infantis - mais comuns - lembra que estas nem sempre se acompanham de espasticidade, podendo apresentar-se, raramente, com hipotonia muscular, ou mesmo de coréia, atetose, ou movimentos córeo-atetóticos que falam em favor de comprometimento extrapiramidal. Assinala, também, que crises epileptiformes - generalizadas ou parciais - podem ocorrer, o mesmo se podendo dizer de distúrbios psíquicos. Traduzir-se-iam, estes, por déficit intelectual marcado, podendo ir desde a debilidade mental até a idiotia; ou então, mesmo quando não há aparente comprometimento da esfera intelectual, por perturbações da afetividade, da vontade e do pragmatismo. Passando em revista as causas mais frequentes das hemiplegias cerebrais infantis, abre lugar, dentre elas, para os empeçonhamentos ofídico e escorpiônico (Magalhães e Guimarães. Estuda, a seguir, a patogenia das hemiplegias no decurso dos referidos empeçonhamentos, alinhando as hipóteses correntes, da preferência de conceituadas autoridades no assunto. Transcreve, finalmente, sua observação clínica, da qual se pode concluir, sem dúvida possível, haver, no caso "que apresenta, estreita e imediata ligação entre o envenenamento ofídico e a hemiparesia em estudo. O observado seria portador, além do mais, de crises epileptiformes generalizadas, aparecidas logo a seguir ao empeçonhamento. Além da fotografia do caso que apresenta, mostra-nos o A. outra, de caso anteriormente publicado, este, porém, de hemiplegia cerebral infantil típica, instalada aos 11 anos, após picada de Bothrops jararaca.

  1. The Duffy-Binding-Like β domain (DBLβ) of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variant, PFD1235w, binds ICAM1

    DEFF Research Database (Denmark)

    Andersen, M. A.; Bengtsson, A.; Rask, Thomas Salhøj

    2012-01-01

    Plasmodium falciparum is by far the most virulent human malaria parasite. P. falciparum variant erythrocyte surface antigens, known as PfEMP1, play a crucial role in malaria pathogenesis as they mediate adhesion to host endothelial receptors. The PfEMP1 variant, PFD1235w, encoded by the 3D7 group...

  2. Insect cells are superior to Escherichia coli in producing malaria proteins inducing IgG targeting PfEMP1 on infected erythrocytes

    DEFF Research Database (Denmark)

    Victor, Michala E; Bengtsson, Anja; Andersen, Gorm

    2010-01-01

    The PFD1235w Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigen is associated with severe malaria in children and can be expressed on the surface of infected erythrocytes (IE) adhering to ICAM1. However, the exact three-dimensional structure of this PfEMP1 and its surface-expos...

  3. Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria

    DEFF Research Database (Denmark)

    Lau, Clinton K.Y.; Turner, Louise; Jespersen, Jakob S.;

    2015-01-01

    The PfEMP1 family of surface proteins is central for Plasmodium falciparum virulence and must retain the ability to bind to host receptors while also diversifying to aid immune evasion. The interaction between CIDRa1 domains of PfEMP1 and endothelial protein C receptor (EPCR) is associated...

  4. La depresión en la infancia desde la perspectiva de las taxonomías empíricas

    OpenAIRE

    1998-01-01

    En este trabajo se analiza la depresión infantil desde el modelo de taxonomías empíricas propuesto por Achenbach y Edelbrock. Se revisan algunos aspectos diferenciales en el diagnóstico de la depresión en menores y adultos. La parte empírica se cent

  5. Surface co-expression of two different PfEMP1 antigens on single Plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1

    DEFF Research Database (Denmark)

    Joergensen, Louise; Bengtsson, Dominique C; Bengtsson, Anja;

    2010-01-01

    The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens play a major role in cytoadhesion of infected erythrocytes (IE), antigenic variation, and immunity to malaria. The current consensus on control of variant surface antigen expression is that only one PfEMP1 encoded by one var...

  6. Análisis semiótico en secuencias de interacción empáticas y no empáticas: un estudio microgenético

    Directory of Open Access Journals (Sweden)

    Pablo Fossa

    Full Text Available Resumen Este estudio tuvo por objetivo explorar y describir el proceso de regulación dialógica en interacciones conversacionales. Se registraron en video treinta díadas de estudiantes desconocidos entre sí en interacciones que tuvieron una manipulación orientada a generar una situación empática o bien no-empática. Se seleccionaron cuatro segmentos de conversación, dos por cada tipo de interacción. El texto fue analizado con un protocolo de análisis semiótico basado en el modelo de análisis propuesto por (Molina, 2007. Los resultados muestran que las interacciones empáticas se caracterizan por un proceso de coconstrucción de significados, con una adecuada administración de la tensión y una identificación con el signo lingüístico. Por otra parte, las interacciones no empáticas se caracterizan por la emergencia de signos lingüísticos que no continúan la secuencia de construcción de significados; con una alta tensión dialógica, y una estrategia de distanciamiento o abandono del campo de significado.

  7. Investigation into the electromagnetic impulses from long-pulse laser illuminating solid targets inside a laser facility

    Science.gov (United States)

    Yi, Tao; Yang, Jinwen; Yang, Ming; Wang, Chuanke; Yang, Weiming; Li, Tingshuai; Liu, Shenye; Jiang, Shaoen; Ding, Yongkun; Xiao, Shaoqiu

    2016-09-01

    Emission of the electromagnetic pulses (EMP) due to laser-target interaction in laser facility had been evaluated using a cone antenna in this work. The microwave in frequencies ranging from several hundreds of MHz to 2 GHz was recorded when long-pulse lasers with several thousands of joules illuminated the solid targets, meanwhile the voltage signals from 1 V to 4 V were captured as functions of laser energy and backlight laser, where the corresponding electric field strengths were obtained by simulating the cone antenna in combination with conducting a mathematical process (Tiknohov Regularization with L curve). All the typical coupled voltage oscillations displayed multiple peaks and had duration of up to 80 ns before decaying into noise and mechanisms of the EMP generation was schematically interpreted in basis of the practical measuring environments. The resultant data were expected to offer basic know-how to achieve inertial confinement fusion.

  8. Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers

    DEFF Research Database (Denmark)

    Turner, Louise; Wang, Christian W; Lavstsen, Thomas;

    2011-01-01

    Antibodies to polymorphic antigens expressed during the parasites erythrocytic stages are important mediators of protective immunity against P. falciparum malaria. Therefore, polymorphic blood stage antigens like MSP3, EBA-175 and GLURP and variant surface antigens PfEMP1 and RIFIN are considered...... antigens, PfEMP1 and RIFIN as well as MSP3 and GLURP, are acquired during a single short low density P. falciparum infection in non-immune individuals including strain transcendent PfEMP1 immune responses. These data indicate that the immunogenicity of the variant surface antigens is similar to the less...... diverse merozoite antigens. The acquisition of a broad and strain transcendent repertoire of PfEMP1 antibodies may reflect a parasite strategy of expressing most or all PfEMP1 variants at liver release optimizing the likelihood of survival and establishment of chronic infections in the new host....

  9. Consideraciones teóricas y empíricas acerca del Resale Price Maintenance

    Directory of Open Access Journals (Sweden)

    DAVID ANDRÉS CAMARGO MAYORGA

    2010-01-01

    orden económico, sino legal. Para ello, el tema se abordará en dos aspectos. En primer lugar, se describen las implicaciones teóricas del RPM, y por otra parte, se muestra la evidencia empírica encontrada a partir de una exploración documental. De manera que la reflexión planteada sugiere que las restricciones verticales evitan el free riding tanto en fabricación como en distribución, dada la tentación de aprovechar el esfuerzo de otros comercializadores en gastos de publicidad, entrenamiento de asesores, reputación de la marca, inversiones en salas de exhibición, etc., en beneficio propio, además de reducir la incertidumbre.

  10. Factores de resistencia ante el ABP: evidencia empírica en contabilidad

    Directory of Open Access Journals (Sweden)

    Javier Corral-Lage

    2015-01-01

    Full Text Available El objetivo de este trabajo es dilucidar cómo la “zona de confort” es el principal óbice para implementar el Aprendizaje Basado en Problemas (ABP. A través de un proceso empírico, se averiguan qué implicaciones supusieron la utilización del ABP frente al tradicional, en los agentes principales: alumnado y profesorado. Se testan opiniones del alumnado mediante encuestas y la del profesorado con grupos de discusión. Se demuestra que la resistencia al cambio para el profesorado, y los miedos y dificultades para dar a conocer sus opiniones por parte de los estudiantes, son la causa principal que dificulta la materialización ABP.

  11. Comercio, empleo y salarios en colombia: teoría y evidencia empírica

    OpenAIRE

    De Lombaerde Philippe

    2009-01-01

    El autor parte de la observación de que el debate académico sobre la apertura en Colombia es un debate demasiado polarizado, y sostiene que se requiere una combinación de teorías y de enfoques para poder analizar el tema, y un mayor énfasis en el análisis empírico. Con base en un análisis de la evidencia disponible hasta el momento, llega a las siguientes conclusiones: i) es la combinación de políticas de apertura, por un lado, y las tendencias en materia del cambio tecnológico y de los cambi...

  12. La dialéctica del amor-odio en Empédocles y Schopenhauer

    Directory of Open Access Journals (Sweden)

    Morales Troncoso, David Emilio

    2010-04-01

    Full Text Available The dialectical thinking can be described as a way of understand an idea which involves the necessary coexistence of the contrary. In the philosophy of Empedocles and Schopenhauer we can find a similar sense of dialectic thought, that is recognized by the last and points to the reevaluation of the moral experience as the ground of representation of the motion of the world of the life.

    El pensamiento dialéctico se puede describir como un modo de concebir una idea que involucra la necesaria coexistencia de su contrario o complementario. En las filosofías de Empédocles y en Schopenhauer se da una semejanza en este sentido, que es advertida por este último y que apunta a la reivindicación de la experiencia moral como soporte de una representación del devenir del mundo de la vida.

  13. Differential PfEMP1 expression is associated with cerebral malaria pathology.

    Directory of Open Access Journals (Sweden)

    Dumizulu L Tembo

    2014-12-01

    Full Text Available Plasmodium falciparum is unique among human malarias in its ability to sequester in post-capillary venules of host organs. The main variant antigens implicated are the P. falciparum erythrocyte membrane protein 1 (PfEMP1, which can be divided into three major groups (A-C. Our study was a unique examination of sequestered populations of parasites for genetic background and expression of PfEMP1 groups. We collected post-mortem tissue from twenty paediatric hosts with pathologically different forms of cerebral malaria (CM1 and CM2 and parasitaemic controls (PC to directly examine sequestered populations of parasites in the brain, heart and gut. Use of two different techniques to investigate this question produced divergent results. By quantitative PCR, group A var genes were upregulated in all three organs of CM2 and PC cases. In contrast, in CM1 infections displaying high levels of sequestration but negligible vascular pathology, there was high expression of group B var. Cloning and sequencing of var transcript tags from the same samples indicated a uniformly low expression of group A-like var. Generally, within an organ sample, 1-2 sequences were expressed at dominant levels. 23% of var tags were detected in multiple patients despite the P. falciparum infections being genetically distinct, and two tags were observed in up to seven hosts each with high expression in the brains of 3-4 patients. This study is a novel examination of the sequestered parasites responsible for fatal cerebral malaria and describes expression patterns of the major cytoadherence ligand in three organ-derived populations and three pathological states.

  14. Differential PfEMP1 Expression Is Associated with Cerebral Malaria Pathology

    Science.gov (United States)

    Tembo, Dumizulu L.; Nyoni, Benjamin; Murikoli, Rekah V.; Mukaka, Mavuto; Milner, Danny A.; Berriman, Matthew; Rogerson, Stephen J.; Taylor, Terrie E.; Molyneux, Malcolm E.; Mandala, Wilson L.; Craig, Alister G.; Montgomery, Jacqui

    2014-01-01

    Plasmodium falciparum is unique among human malarias in its ability to sequester in post-capillary venules of host organs. The main variant antigens implicated are the P. falciparum erythrocyte membrane protein 1 (PfEMP1), which can be divided into three major groups (A–C). Our study was a unique examination of sequestered populations of parasites for genetic background and expression of PfEMP1 groups. We collected post-mortem tissue from twenty paediatric hosts with pathologically different forms of cerebral malaria (CM1 and CM2) and parasitaemic controls (PC) to directly examine sequestered populations of parasites in the brain, heart and gut. Use of two different techniques to investigate this question produced divergent results. By quantitative PCR, group A var genes were upregulated in all three organs of CM2 and PC cases. In contrast, in CM1 infections displaying high levels of sequestration but negligible vascular pathology, there was high expression of group B var. Cloning and sequencing of var transcript tags from the same samples indicated a uniformly low expression of group A-like var. Generally, within an organ sample, 1–2 sequences were expressed at dominant levels. 23% of var tags were detected in multiple patients despite the P. falciparum infections being genetically distinct, and two tags were observed in up to seven hosts each with high expression in the brains of 3–4 patients. This study is a novel examination of the sequestered parasites responsible for fatal cerebral malaria and describes expression patterns of the major cytoadherence ligand in three organ-derived populations and three pathological states. PMID:25473835

  15. Team-Based Programs: The EMP. An Industry/University Partnership-The Educational Model for the 21st Century.

    Science.gov (United States)

    Haynes, Ray; And Others

    California Polytechnic State University's College of Business and College of Engineering have joined forces to create a joint Engineering Management Program (EMP). Students holding undergraduate engineering or equivalent degrees enter and earn both Masters in Business Administration and Masters of Science in Engineering in 24 months. The program…

  16. PfEMP1 - A Parasite Protein Family of Key Importance in Plasmodium falciparum Malaria Immunity and Pathogenesis.

    Science.gov (United States)

    Hviid, Lars; Jensen, Anja T R

    2015-04-01

    Plasmodium falciparum causes the most severe form of malaria and is responsible for essentially all malaria-related deaths. The accumulation in various tissues of erythrocytes infected by mature P. falciparum parasites can lead to circulatory disturbances and inflammation, and is thought to be a central element in the pathogenesis of the disease. It is mediated by the interaction of parasite ligands on the erythrocyte surface and a range of host receptor molecules in many organs and tissues. Among several proteins and protein families implicated in this process, the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family of high-molecular weight and highly variable antigens appears to be the most prominent. In this chapter, we aim to provide a systematic overview of the current knowledge about these proteins, their structure, their function, how they are presented on the erythrocyte surface, and how the var genes encoding them are regulated. The role of PfEMP1 in the pathogenesis of malaria, PfEMP1-specific immune responses, and the prospect of PfEMP1-specific vaccination against malaria are also covered briefly. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Time-resolved absolute measurements by electro-optic effect of giant electromagnetic pulses due to laser-plasma interaction in nanosecond regime

    Science.gov (United States)

    Consoli, F.; de Angelis, R.; Duvillaret, L.; Andreoli, P. L.; Cipriani, M.; Cristofari, G.; di Giorgio, G.; Ingenito, F.; Verona, C.

    2016-06-01

    We describe the first electro-optical absolute measurements of electromagnetic pulses (EMPs) generated by laser-plasma interaction in nanosecond regime. Laser intensities are inertial-confinement-fusion (ICF) relevant and wavelength is 1054 nm. These are the first direct EMP amplitude measurements with the detector rather close and in direct view of the plasma. A maximum field of 261 kV/m was measured, two orders of magnitude higher than previous measurements by conductive probes on nanosecond regime lasers with much higher energy. The analysis of measurements and of particle-in-cell simulations indicates that signals match the emission of charged particles detected in the same experiment, and suggests that anisotropic particle emission from target, X-ray photoionization and charge implantation on surfaces directly exposed to plasma, could be important EMP contributions. Significant information achieved on EMP features and sources is crucial for future plants of laser-plasma acceleration and inertial-confinement-fusion and for the use as effective plasma diagnostics. It also opens to remarkable applications of laser-plasma interaction as intense source of RF-microwaves for studies on materials and devices, EMP-radiation-hardening and electromagnetic compatibility. The demonstrated extreme effectivity of electric-fields detection in laser-plasma context by electro-optic effect, leads to great potential for characterization of laser-plasma interaction and generated Terahertz radiation.

  18. Excimer Laser Pulse Compress With Pulse Feedback

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>To attain a shorter laser pulse, a compressing technique called pulse feedback was developed from the saturation gain switch applied to the amplification in a discharge pumping excimer laser cavity. It can

  19. Approaches to Simulating the Prompt Electromagnetic Pulse

    Science.gov (United States)

    Friedman, Alex; Cohen, Bruce I.; Eng, Chester D.; Farmer, William A.; Grote, David P.; Kruger, Hans W.; Larson, David J.

    2016-10-01

    LLNL is developing a suite of modern tools for simulating the generation and propagation of the prompt (E1) electromagnetic pulse (EMP). These include the 3-D EMPulse code, based on PIC methods with a Cartesian grid in the laboratory frame, and a companion 3-D approach which builds on the methods used in Longmire's fast-running CHAP code. In CHAP, and in our own CHAP-lite, 1-D spherical symmetry is assumed, and the calculation takes advantage of a separation of scales. The independent coordinates are (r, τ) , where r is the distance from the source and τ = t-r/c; the pulse varies slowly with r at fixed τ, so a coarse radial grid can be used. We seek similar efficiencies in 3-D, incorporating non-spherically-symmetric physics via a vector spherical harmonic decomposition. For each (l,m) harmonic, the radial equation is similar to that in CHAP-lite. We describe this approach, along with other aspects of our project. This work was performed under the auspices of the U.S. DOE by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  20. Pulsed Optics

    Science.gov (United States)

    Hirlimann, C.

    Optics is the field of physics which comprises knowledge on the interaction between light and matter. When the superposition principle can be applied to electromagnetic waves or when the properties of matter do not depend on the intensity of light, one speaks of linear optics. This situation occurs with regular light sources such as light bulbs, low-intensity light-emitting diodes and the sun. With such low-intensity sources the reaction of matter to light can be characterized by a set of parameters such as the index of refraction, the absorption and reflection coefficients and the orientation of the medium with respect to the polarization of the light. These parameters depend only on the nature of the medium. The situation changed dramatically after the development of lasers in the early sixties, which allowed the generation of light intensities larger than a kilowatt per square centimeter. Actual large-scale short-pulse lasers can generate peak powers in the petawatt regime. In that large-intensity regime the optical parameters of a material become functions of the intensity of the impinging light. In 1818 Fresnel wrote a letter to the French Academy of Sciences in which he noted that the proportionality between the vibration of the light and the subsequent vibration of matter was only true because no high intensities were available. The intensity dependence of the material response is what usually defines nonlinear optics.

  1. Survey Questionnaire on Environmental Management Practices: Summary of Results by Industry and practices

    OpenAIRE

    Delmas, Magali A; Michael W. Toffel

    2008-01-01

    This document provides a summary of the results of a survey on Environmental Management Practices (EMP) conducted by the University of California at Santa Barbara during October and November 2003. The survey was sent to 3255 facilities in 8 industrial sectors: pulp, paper and paperboard mills, chemical and allied products, refining, primary metals, machinery, electronics /electrical, automotive, and utilities. The survey yielded 562 responses, which constitutes a 17.2% response rate. This sum...

  2. Plasma Ang2 and ADAM17 levels are elevated during clinical malaria; Ang2 level correlates with severity and expression of EPCR-binding PfEMP1

    DEFF Research Database (Denmark)

    Petersen, Jens E V; Mkumbaye, Sixbert I; Vaaben, Anna V;

    2016-01-01

    Membrane Protein 1 (PfEMP1) containing Cysteine Rich Inter Domain Region α1 (CIDRα1) domains predicted to bind Endothelial Protein C receptor (EPCR). ADAM17 levels were not associated with expression of var genes encoding different PfEMP1 types when controlling for age. These data are the first to report...... ADAM17 plasma levels in malaria-exposed individuals, and support the notion that parasite sequestration mediated by EPCR-binding PfEMP1 is associated with endothelial activation and pathology in severe paediatric malaria....

  3. Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from em>P. falciparum malaria

    DEFF Research Database (Denmark)

    Magistrado, Pamela A; Lusingu, John; Vestergaard, Lasse S;

    2007-01-01

    Variant surface antigens (VSA) on the surface of Plasmodium falciparum-infected red blood cells play a major role in the pathogenesis of malaria and are key targets for acquired immunity. The best-characterized VSA belong to the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family. In areas...... where P. falciparum is endemic, parasites causing severe malaria and malaria in young children with limited immunity tend to express semiconserved PfEMP1 molecules encoded by group A var genes. Here we investigated antibody responses of Tanzanians who were 0 to 19 years old to PF11_0008, a group A PfEMP...

  4. Programmable pulse generator

    CERN Document Server

    Xue Zhi Hua; Duan Xiao Hui

    2002-01-01

    The author introduces the design of programmable pulse generator that is based on a micro-controller and controlled by RS232 interface of personal computer. The whole system has good stability. The pulse generator can produce TTL pulse and analog pulse. The pulse frequency can be selected by EPLD. The voltage amplitude and pulse width of analog pulse can be adjusted by analog switches and digitally-controlled potentiometers. The software development tools of computer is National Instruments LabView5.1. The front panel of this virtual instrumentation is intuitive and easy-to-use. Parameters can be selected and changed conveniently by knob and slide

  5. Um estudo empírico de um sistema de reconhecimento facial utilizando o classificador KNN

    Directory of Open Access Journals (Sweden)

    Fabio Abrantes Diniz

    2016-06-01

    Full Text Available Neste artigo, apresenta-se um estudo empírico de otimização das taxas de acurácias resultantes de um sistema de reconhecimento facial baseado nas técnicas Eigenfaces e K-Nearest Neighbors. Foram investigadas as seguintes variáveis: imagens com três dimensões distintas, número de características (Eigenfaces, valores de k da técnica K-Nearest Neighbors e três medidas de distância (euclidiana, Manhattan e euclidiana normalizada. Os estudos foram importantes para entender empiricamente quais parâmetros são os mais relevantes para as técnicas analisadas e que resultam em melhores taxas de acurácias de reconhecimento facial. Os resultados dos experimentos comprovaram que as imagens com dimensões 12x9 pixels produzem as melhores taxas de acurácias de reconhecimento facial, combinando com a medida de distância euclidiana normalizada e um número de Eigenfaces igual a vinte.

  6. PPIC, EMP3 and CHI3L1 Are Novel Prognostic Markers for High Grade Glioma

    Science.gov (United States)

    Gao, Yuan-Feng; Zhu, Tao; Mao, Chen-Xue; Liu, Zhi-Xiong; Wang, Zhi-Bin; Mao, Xiao-Yuan; Li, Ling; Yin, Ji-Ye; Zhou, Hong-Hao; Liu, Zhao-Qian

    2016-01-01

    Current treatment methods for patients diagnosed with gliomas have shown limited success. This is partly due to the lack of prognostic genes available to accurately predict disease outcomes. The aim of this study was to investigate novel prognostic genes based on the molecular profile of tumor samples and their correlation with clinical parameters. In the current study, microarray data (GSE4412 and GSE7696) downloaded from Gene Expression Omnibus were used to identify differentially expressed prognostic genes (DEPGs) by significant analysis of microarray (SAM) between long-term survivors (>2 years) and short-term survivors (≤2 years). DEPGs generated from these two datasets were intersected to obtain a list of common DEPGs. The expression of a subset of common DEPGs was then independently validated by real-time reverse transcription quantitative PCR (qPCR). Survival value of the common DEPGs was validated using known survival data from the GSE4412 and TCGA dataset. After intersecting DEPGs generated from the above two datasets, three genes were identified which may potentially be used to determine glioma patient prognosis. Independent validation with glioma patients tissue (n = 70) and normal brain tissue (n = 19) found PPIC, EMP3 and CHI3L1 were up-regulated in glioma tissue. Survival value validation showed that the three genes correlated with patient survival by Kaplan-Meir analysis, including grades, age and therapy. PMID:27801851

  7. Claudins reign: The claudin/EMP/PMP22/γ channel protein family in C. elegans.

    Science.gov (United States)

    Simske, Jeffrey S

    2013-07-01

    The claudin family of integral membrane proteins was identified as the major protein component of the tight junctions in all vertebrates. Since their identification, claudins, and their associated pfam00822 superfamily of proteins have been implicated in a wide variety of cellular processes. Claudin homologs have been identified in invertebrates as well, including Drosophila and C. elegans. Recent studies demonstrate that the C. elegans claudins, clc-1-clc- 5, and similar proteins in the greater PMP22/EMP/claudin/voltage-gated calcium channel γ subunit family, including nsy-4, and vab-9, while highly divergent at a sequence level from each other and from the vertebrate claudins, in many cases play roles similar to those traditionally assigned to their vertebrate homologs. These include regulating cell adhesion and passage of small molecules through the paracellular space, channel activity, protein aggregation, sensitivity to pore-forming toxins, intercellular signaling, cell fate specification and dynamic changes in cell morphology. Study of claudin superfamily proteins in C. elegans should continue to provide clues as to how claudin family protein function has been adapted to perform diverse functions at specialized cell-cell contacts in metazoans.

  8. Matrimonios mixtos intraeuropeos: un modelo empírico (Intra-European intermarriage: an empirical model

    Directory of Open Access Journals (Sweden)

    Alaminos Chica, Antonio Francisco

    2008-06-01

    Full Text Available Resumen: La heterogeneidad con la que nos encontramos al estudiar las parejas interculturales o mixtas, va más allá de las diferencias de origen sociocultural; interviene factores tales como el rol que cada individuo adopta dentro de la pareja (por ejemplo, quién contribuye más económicamente, el status, el nivel educativo, etc.. En este artículo se propone un modelo empírico que muestra el efecto de un conjunto de variables, que expresan circunstancias sociales, sobre la decisión de formar un matrimonio interculturalmente mixto. También las consecuencias en la vida social del individuo.Abstract: The intercultural marriages or mixed marriages depend upon several factor. Not only the different cultural origin. Other determinants like the role of the partner (i.e. economic contribution, status, educational level, etc. or the type of the family (modern, traditional, etc. influence the outcomes. This paper contains a proposal of empirical model for study the intra-European mixed marriages.

  9. La relación entre creatividad y expertise: contribuciones teóricas y empíricas

    Directory of Open Access Journals (Sweden)

    Afonso C. T. Galvao

    2009-06-01

    Full Text Available La creatividad y el expertise son temas que están recibiendo mayor atención de los inves­tigadores en distintos campos del conocimiento. Atributos personales asociados a la alta producción creativa, factores que favorecen el desarrollo, la expresión de la creatividad y el expertise, así como los procesos implicados en el desarrollo de la alta competencia y la creatividad, son temas que han sido objeto de numerosos estudios. El presente estudio pre­senta contribuciones teóricas y estudios empíricos acerca de la creatividad y el expertise. Se describen los elementos comunes para el desarrollo de la creatividad y el expertise, así como las características de los ambientes educativos que los promueven, los modelos teóricos y estudios empíricos.

  10. PENGOLAHAN BUAH DAN BIJI RAMBUTAN SEBAGAI MAKANAN TRADISIONAL KOKTAIL, MANISAN, EMPING BIJI RAMBUTAN DAN OBAT HERBAL YANG BERKHASIAT

    Directory of Open Access Journals (Sweden)

    Nuni Widiarti

    2013-02-01

    Full Text Available Kegiatan pengabdian kepada masyarakat berupa penyuluhan Pengolahan Buah Dan Biji Rambutan Sebagai Makanan Tradisional Koktail, Manisan, Emping Biji Rambutan Dan Obat Herbal Yang Berkhasiat bertujuan untuk memberikan pengetahuan kepada masyarakat khususnya ibu-ibu PKK dukuh kanggan Desa Wringinputih terhadap manfaat rambutan, dan biji rambutan terhadap kesehatan beserta bagaimana meningkatkan nilai jual rambutan dan biji rambutan pada saat panen raya. Khalayak sasaran dalam pengabdian masyarakat ini adalah ibu-ibu rumah tangga di dukuh Kanggan Desa Wringinputih khususnya warga RT 01 dan 02 RW XIII yang berjumlah 20 orang. Metode yang dilakukan dalam pngabdian ini adalah penyuluhan dan demonstrasi pembuatan emping serta manisan buah rambutan. Manfaat yang diperoleh dari hasil pengabdian ini adalah masyarakat menjadi tahu manfaat dari daun hingga akar dan buah rambutan terhadap berbagai penyakit dan kecantikan.

  11. La ilusión científica en la macroeconomía empírica

    OpenAIRE

    Summers Lawrence H.

    1995-01-01

    Muchos macroeconomistas y la mayoría de los econometristas creen y enseñan a sus estudiantes que 1) el trabajo empírico en macroeconomía debe dedicarse a identificar los ‘parámetros estructurales básicos’ que representan las preferencias y la tecnología; 2) el mejor trabajo empírico en macroeconomía prueba formalmente las hipótesis esenciales derivadas rigurosamente de la teoría económica; 3) las técnicas estadísticas sofisticadas pueden jugar un papel importante para determinar la causación ...

  12. Numerical Simulation of Transient Gauss pulse Coupling through Small Apertures

    Directory of Open Access Journals (Sweden)

    Jinshi Xiao

    2011-08-01

    Full Text Available Transient electromagnetic pulse (EMP can easily couple into equipments through small apertures in its shells. To study the coupling effects of transient Gauss pulse to a cubic cavity with openings, coupling course is simulated using sub-gridding finite difference in time domain (FDTD algorithm in this paper. A new grid partition approach is provided to simulate each kind of apertures with complex shapes. With this approach, the whole calculation space is modeled, and six kinds of aperture with different shapes are simulated. Coupling course is simulate in the whole time domain using sub-gridding FDTD approach. Selecting apertures with dimension of several millimeters to research, coupled electric field waveform, power density and coupling coefficient are calculated. The affect on coupling effects by varied incident angle and varied pulse width are also analyzed. The main conclusion includes interior resonance phenomenon, increase effect around rectangle aperture and several distributing rules of coupled electric field in the cavity. The correctness of these results is validated by comparing with other scholars’ results. These numerical results can help us to understand coupling mechanism of the transient Gauss pulse.

  13. STATIC{sub T}EMP: a useful computer code for calculating static formation temperatures in geothermal wells

    Energy Technology Data Exchange (ETDEWEB)

    Santoyo, E. [Universidad Nacional Autonoma de Mexico, Centro de Investigacion en Energia, Temixco (Mexico); Garcia, A.; Santoyo, S. [Unidad Geotermia, Inst. de Investigaciones Electricas, Temixco (Mexico); Espinosa, G. [Universidad Autonoma Metropolitana, Co. Vicentina (Mexico); Hernandez, I. [ITESM, Centro de Sistemas de Manufactura, Monterrey (Mexico)

    2000-07-01

    The development and application of the computer code STATIC{sub T}EMP, a useful tool for calculating static formation temperatures from actual bottomhole temperature data logged in geothermal wells is described. STATIC{sub T}EMP is based on five analytical methods which are the most frequently used in the geothermal industry. Conductive and convective heat flow models (radial, spherical/radial and cylindrical/radial) were selected. The computer code is a useful tool that can be reliably used in situ to determine static formation temperatures before or during the completion stages of geothermal wells (drilling and cementing). Shut-in time and bottomhole temperature measurements logged during well completion activities are required as input data. Output results can include up to seven computations of the static formation temperature by each wellbore temperature data set analysed. STATIC{sub T}EMP was written in Fortran-77 Microsoft language for MS-DOS environment using structured programming techniques. It runs on most IBM compatible personal computers. The source code and its computational architecture as well as the input and output files are described in detail. Validation and application examples on the use of this computer code with wellbore temperature data (obtained from specialised literature) and with actual bottomhole temperature data (taken from completion operations of some geothermal wells) are also presented. (Author)

  14. VizieR Online Data Catalog: Exploring the SDSS data set. I. EMP & CV stars (Carbon+, 2017)

    Science.gov (United States)

    Carbon, D. F.; Henze, C.; Nelson, B. C.

    2017-08-01

    We present the results of a search for extremely metal-poor (EMP), carbon-enhanced metal-poor (CEMP), and cataclysmic variable (CV) stars using a new exploration tool based on linked scatter plots (LSPs). Our approach is especially designed to work with very large spectrum data sets such as the SDSS, LAMOST, RAVE, and Gaia data sets, and it can be applied to stellar, galaxy, and quasar spectra. As a demonstration, we conduct our search using the SDSS DR10 data set. We first created a 3326-dimensional phase space containing nearly 2 billion measures of the strengths of over 1600 spectral features in 569738 SDSS stars. These measures capture essentially all the stellar atomic and molecular species visible at the resolution of SDSS spectra. We show how LSPs can be used to quickly isolate and examine interesting portions of this phase space. To illustrate, we use LSPs coupled with cuts in selected portions of phase space to extract EMP stars, CEMP stars, and CV stars. We present identifications for 59 previously unrecognized candidate EMP stars and 11 previously unrecognized candidate CEMP stars. We also call attention to 2 candidate He II emission CV stars found by the LSP approach that have not yet been discussed in the literature. (3 data files).

  15. A influência da idade e da escolaridade sobre a experiência empática de adultos

    Directory of Open Access Journals (Sweden)

    Vanessa Dordron de Pinho

    2011-08-01

    Full Text Available Atualmente, os teóricos começam a compartilhar uma visão da experiência empática humana como um fenômeno multidimensional influenciado por diversos aspectos, dentre eles, a idade e a escolaridade. No presente estudo, investigou-se as relações entre a habilidade social empática e essas duas variáveis sociodemográficas, em 537 participantes adultos. A habilidade empática foi estudada em quatro dimensões, que correspondem aos quatro fatores que compõem o instrumento utilizado, o Inventário de Empatia (IE: Tomada de Perspectiva (TP, Flexibilidade Interpessoal (FI, Altruísmo (Al e Sensibilidade Afetiva (SA. Os resultados indicaram correlações significativas do ponto de vista estatístico entre idade e dois aspectos da empatia: altruísmo e sensibilidade afetiva. Os grupos de escolaridade se diferenciaram quanto à flexibilidade interpessoal e ao altruísmo. Através deste artigo é possível hipotetizar que as variáveis estudadas estão relacionadas à empatia, corroborando estudos anteriores que apontam como variáveis cognitivas caminham juntas com o desenvolvimento e podem ser afetadas pelo aprimoramento educacional.

  16. Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant

    DEFF Research Database (Denmark)

    Petersen, Jens E V; Bouwens, Eveline A M; Tamayo, Ibai;

    2015-01-01

    The Endothelial Protein C receptor (EPCR) is essential for the anticoagulant and cytoprotective functions of the Protein C (PC) system. Selected variants of the malaria parasite protein, Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) associated with severe malaria, including cerebral...... malaria, specifically target EPCR on vascular endothelial cells. Here, we examine the cellular response to PfEMP1 engagement to elucidate its role in malaria pathogenesis. Binding of the CIDRα1.1 domain of PfEMP1 to EPCR obstructed activated PC (APC) binding to EPCR and induced a loss of cellular EPCR...... not interfere with (A)PC binding to cellular EPCR. E86A-sEPCR used as a decoy to capture PfEMP1, permitted normal PC activation on endothelial cells, normal barrier protective effects of APC, and greatly reduced cytoadhesion of infected erythrocytes to brain endothelial cells. These data imply important...

  17. Mapping the binding site of a cross-reactive Plasmodium falciparum PfEMP1 monoclonal antibody inhibitory of ICAM-1 binding

    DEFF Research Database (Denmark)

    Lennartz, Frank; Bengtsson, Anja; Olsen, Rebecca W

    2015-01-01

    The virulence of Plasmodium falciparum is linked to the ability of infected erythrocytes (IE) to adhere to the vascular endothelium, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). In this article, we report the functional characterization of an mAb that recognizes a panel of Pf......EMP1s and inhibits ICAM-1 binding. The 24E9 mouse mAb was raised against PFD1235w DBLβ3_D4, a domain from the group A PfEMP1s associated with severe malaria. 24E9 recognizes native PfEMP1 expressed on the IE surface and shows cross-reactivity with and cross-inhibition of the ICAM-1 binding capacity...

  18. Efficacy of estramustine phosphate sodium hydrate (EMP) monotherapy in castration-resistant prostate cancer patients: report of 102 cases and review of literature.

    Science.gov (United States)

    Matsumoto, Kazuhiro; Tanaka, Nobuyuki; Hayakawa, Nozomi; Ezaki, Taisuke; Suzuki, Kenjiro; Maeda, Takahiro; Ninomiya, Akiharu; Nakamura, So

    2013-12-01

    This retrospective chart review study was conducted to evaluate the efficacy of estramustine phosphate sodium hydrate (EMP) monotherapy in patients with castration-resistant prostate cancer (CRPC) and to determine who would benefit from EMP therapy. EMP was administered at a daily dose of 560 mg to 102 patients as a third-line therapy, who had already received combined androgen blockade (CAB) and subsequent alternative antiandrogen therapy. The responses to EMP after its induction and its toxicity were evaluated. We also analyzed the association between the clinicopathological factors of the patients and their responses to EMP therapy. A reduction in the serum prostate-specific antigen (PSA) 4 weeks after induction was observed in 70 patients (68.6%), while 30 cases (29.4%) achieved more than 50% reduction of PSA. Long-term reduction of PSA from baseline for more than 6 months was observed in 31 patients (30.4%). EMP treatment was discontinued in 11 patients (10.8%) because of side effects (nausea in six patients, gynecomastia in three patients, eruption in one patient, and liver dysfunction in one patient). Multivariate analysis demonstrated that long duration of prior hormonal therapy was an independent favorable factor for reduced PSA levels, long responses, and overall survival. The data suggest that oral EMP administration as a third-line monotherapy is well tolerated and effective to some degree in patients with CRPC who have already received CAB and subsequent alternative antiandrogen therapy. Thus, EMP can be regarded as one treatment option, especially for patients whose prior duration of hormonal therapy was long.

  19. Recommended engineering practice to enhance the EMI/EMP immunity of electric power systems

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, C.L.; Feero, W.E. [Electric Research and Management, Inc., State College, PA (United States)

    1992-12-01

    Many papers and reports have been written on studies conducted by the Oak Ridge National Laboratory and investigations by others on the effect of high-altitude electromagnetic pulses (HEMP) on electric power systems. More than 100 of the published unclassified documents were reviewed with the objectives of: 1. summarizing the mitigation methods suggested in the documents and providing a subjective evaluation of each 2. discussing various standards . that presently apply to the effects of HEMP on utility systems and suggesting additions or modifications or new standards where deficiencies appear to exist; and 3. recommending future studies or actions to improve the utility response to HEMP. While all three components of HEMP were mentioned, only the early-time short-duration E{sub 1} pulse and the late-time long-duration E{sub 3} pulse were considered in detail; the E{sub 2} intermediate component was not considered to affect the power system significantly.

  20. Recommended engineering practice to enhance the EMI/EMP immunity of electric power systems

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, C.L.; Feero, W.E. (Electric Research and Management, Inc., State College, PA (United States))

    1992-12-01

    Many papers and reports have been written on studies conducted by the Oak Ridge National Laboratory and investigations by others on the effect of high-altitude electromagnetic pulses (HEMP) on electric power systems. More than 100 of the published unclassified documents were reviewed with the objectives of: 1. summarizing the mitigation methods suggested in the documents and providing a subjective evaluation of each 2. discussing various standards . that presently apply to the effects of HEMP on utility systems and suggesting additions or modifications or new standards where deficiencies appear to exist; and 3. recommending future studies or actions to improve the utility response to HEMP. While all three components of HEMP were mentioned, only the early-time short-duration E[sub 1] pulse and the late-time long-duration E[sub 3] pulse were considered in detail; the E[sub 2] intermediate component was not considered to affect the power system significantly.

  1. Structure and biological activities of eumenine mastoparan-AF (EMP-AF), a new mast cell degranulating peptide in the venom of the solitary wasp (Anterhynchium flavomarginatum micado).

    Science.gov (United States)

    Konno, K; Hisada, M; Naoki, H; Itagaki, Y; Kawai, N; Miwa, A; Yasuhara, T; Morimoto, Y; Nakata, Y

    2000-11-01

    A new mast cell degranulating peptide, eumenine mastoparan-AF (EMP-AF), was isolated from the venom of the solitary wasp Anterhynchium flavomarginatum micado, the most common eumenine wasp found in Japan. The structure was analyzed by FAB-MS/MS together with Edman degradation, which was corroborated by solid-phase synthesis. The sequence of EMP-AF, Ile-Asn-Leu-Leu-Lys-Ile-Ala-Lys-Gly-Ile-Ile-Lys-Ser-Leu-NH(2), was similar to that of mastoparan, a mast cell degranulating peptide from a hornet venom; tetradecapeptide with C-terminus amidated and rich in hydrophobic and basic amino acids. In fact, EMP-AF exhibited similar activity to mastoparan in stimulating degranulation from rat peritoneal mast cells and RBL-2H3 cells. It also showed significant hemolytic activity in human erythrocytes. Therefore, this is the first example that a mast cell degranulating peptide is found in the solitary wasp venom. Besides the degranulation and hemolytic activity, EMP-AF also affects on neuromuscular transmission in the lobster walking leg preparation. Three analogs EMP-AF-1 approximately 3 were snythesized and biologically tested together with EMP-AF, resulting in the importance of the C-terminal amide structure for biological activities.

  2. Electromagnetic Pulses Generated From Laser Target Interactions at Shenguang II Laser Facility

    Science.gov (United States)

    Yang, Jinwen; Li, Tingshuai; Yi, Tao; Wang, Chuanke; Yang, Ming; Yang, Weiming; Liu, Shenye; Jiang, Shaoen; Ding, Yongkun

    2016-10-01

    Significant electromagnetic pulses (EMP) can be generated by the intensive laser irradiating solid targets in inertial confinement fusion (ICF). To evaluate the EMP intensity and distribution in and outside the laser chamber, we designed and fabricated a discone antenna with ultra-wide bands of over 10 GHz. The return loss (S11 parameter) of this antenna was below -10 dB and could even achieve under -30 dB at 3.1 GHz. The EMP intensity in this study at 80 cm and 40 cm away from the target chamber center (TCC) reached 400 kV/m and 2000 kV/m. The current results are expected to offer preliminary information to study physics regarding laser plasma interactions and will also lay experimental foundation for EMI shielding design to protect various diagnostics. supported by the Fundamental Research Funds for the Central Universities of China (No. ZYGX2015J108) and National Natural Science Foundation of China (Nos. 11575166 and 51581140)

  3. Efectividad del aprendizaje cooperativo en contabilidad: una contrastación empírica

    Directory of Open Access Journals (Sweden)

    María del Mar Delgado Hurtado

    2015-07-01

    Full Text Available La presente investigación tiene como objetivo verificar uno de los principales beneficios atribuidos a la metodología docente «aprendizaje cooperativo»: la obtención de mejores resultados de aprendizaje. Para ello hemos realizado un cuasiexperimento con la finalidad de comparar las calificaciones de un grupo de alumnos, en cuyo proceso de aprendizaje se ha empleado el aprendizaje cooperativo junto con la clase magistral, con las calificaciones de otro grupo, donde solo ha sido utilizada la clase magistral. Los resultados obtenidos tras la aplicación de un análisis de covarianza (ANCOVA, controlando el género, edad, las calificaciones previas del alumno, asistencia a clase, dedicación y motivación, revelan mejores resultados en el grupo de aprendizaje cooperativo que en el grupo de clase magistral. Adicionalmente comprobamos la efectividad de la metodología del aprendizaje cooperativo en diferentes niveles de aprendizaje, de acuerdo con la taxonomía de Bloom (1956. Los resultados reflejan diferencias significativas en el nivel de aplicación-análisis pero no en el nivel conocimiento-comprensión. Este trabajo contribuye a la literatura empírica sobre aprendizaje cooperativo, proporcionando evidencia adicional sobre la obtención de mejores resultados de aprendizaje en contabilidad, tras haber controlado el efecto de variables que previamente no habían sido consideradas en la contrastación de esta metodología como la dedicación del alumno y la motivación.

  4. Interaction of electromagnetic pulse with commercial nuclear-power-plant systems

    Energy Technology Data Exchange (ETDEWEB)

    Ericson, D.M. Jr.; Strawe, D.F.; Sandberg, S.J.; Jones, V.K.; Rensner, G.D.; Shoup, R.W.; Hanson, R.J.; Williams, C.B.

    1983-02-01

    This study examines the interaction of the electromagnetic pulse from a high altitude nuclear burst with commercial nuclear power plant systems. The potential vulnerability of systems required for safe shutdown of a specific nuclear power plant are explored. EMP signal coupling, induced plant response and component damage thresholds are established using techniques developed over several decades under Defense Nuclear Agency sponsorship. A limited test program was conducted to verify the coupling analysis technique as applied to a nuclear power plant. The results are extended, insofar as possible, to other nuclear plants.

  5. Radial pulse (image)

    Science.gov (United States)

    ... heart. The arteries are the vessels with the "pulse", a rhythmic pushing of the blood in the ... a refilling of the heart chamber. To determine heart rate, one feels the beats at a pulse point ...

  6. Wrist pulse (image)

    Science.gov (United States)

    To measure the pulse at the wrist, place the index and middle finger over the underside of the opposite wrist, below the base ... firmly with flat fingers until you feel the pulse in the radial artery.

  7. Endothelial microparticles (EMP for the assessment of endothelial function: an in vitro and in vivo study on possible interference of plasma lipids.

    Directory of Open Access Journals (Sweden)

    Sabrina H van Ierssel

    Full Text Available BACKGROUND: Circulating endothelial microparticles (EMP reflect the condition of the endothelium and are of increasing interest in cardiovascular and inflammatory diseases. Recently, increased numbers of EMP following oral fat intake, possibly due to acute endothelial injury, have been reported. On the other hand, the direct interference of lipids with the detection of EMP has been suggested. This study aimed to investigate the effect of lipid-rich solutions, commonly administered in clinical practice, on the detection, both in vitro and in vivo, of EMP. METHODS: For the in vitro assessment, several lipid-rich solutions were added to whole blood of healthy subjects (n = 8 and patients with coronary heart disease (n = 5. EMP (CD31+/CD42b- were detected in platelet poor plasma by flow cytometry. For the in vivo study, healthy volunteers were evaluated on 3 different study-days: baseline evaluation, following lipid infusion and after a NaCl infusion. EMP quantification, lipid measurements and peripheral arterial tonometry were performed on each day. RESULTS: Both in vitro addition and in vivo administration of lipids significantly decreased EMP (from 198.6 to 53.0 and from 272.6 to 90.6/µl PPP, respectively, p = 0.001 and p = 0.012. The EMP number correlated inversely with the concentration of triglycerides, both in vitro and in vivo (r = -0.707 and -0.589, p<0.001 and p = 0.021, respectively. The validity of EMP as a marker of endothelial function is supported by their inverse relationship with the reactive hyperemia index (r = -0.758, p = 0.011. This inverse relation was confounded by the intravenous administration of lipids. CONCLUSION: The confounding effect of high circulating levels of lipids, commonly found in patients that receive intravenous lipid-based solutions, should be taken into account when flow cytometry is used to quantify EMP.

  8. MnSOD expression inhibited by electromagnetic pulse radiation in the rat testis.

    Science.gov (United States)

    Zeng, LiHua; Ji, XiTuan; Zhang, YanJun; Miao, Xia; Zou, ChangXu; Lang, HaiYang; Zhang, Jie; Li, YuRong; Wang, XiaoWu; Qi, HongXing; Ren, DongQin; Guo, GuoZhen

    2011-12-01

    Male Sprague Dawley rats were exposed to EMP irradiation of 100 kV/m peak-to-peak e-field intensity and different numbers of pulses. Rat sperm samples were prepared for analysis of sperm qualities; Testes were assessed by transmission electron microscopy and serum hormone concentrations were examined by radioimmunoassay; Enzymatic activities of Total-superoxide dismutase(T-SOD) and manganese-superoxide dismutase (MnSOD), the mRNA levels of MnSOD and cuprozinc-superoxide dismutase (CuZnSOD), and the density of malondialdehyde (MDA) were also determined. EMP irradiation did not affect spermatozoon morphology, micronucleus formation rate, sperm number or viability, but the acrosin reaction rate decreased at 24 h and 48 h and recovered by 72 h after irradiation as compared to the controls. The ultrastructure of rat testis displayed more serious damage at 24 h than at other time points (6 h, 12 h, 48 h). Serum levels of luteotrophic hormone (LH) and testosterone (T) were elevated in irradiated rats as compared to controls. After irradiation, enzymatic activities of T-SOD and MnSOD were reduced by 24 h, consistent with the changes observed in MnSOD mRNA expression; MDA content increased at 6 h in turn. These studies have quantified the morphological damage and dysfunction in the rat reproductive system induced by EMP. The mechanism of EMP induced damage may be associated with the inhibition of MnSOD expression.

  9. Pulse-Width Jitter Measurement for Laser Diode Pulses

    Institute of Scientific and Technical Information of China (English)

    TANG Jun-Hua; WANG Yun-Cai

    2006-01-01

    @@ Theoretical analysis and experimental measurement of pulse-width jitter of diode laser pulses are presented. The expression of pulse power spectra with all amplitude jitter, timing jitter and pulse-width jitter is deduced.

  10. Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.

    Directory of Open Access Journals (Sweden)

    Ashfaq Ghumra

    Full Text Available BACKGROUND: Rosetting is a Plasmodium falciparum virulence factor implicated in the pathogenesis of life-threatening malaria. Rosetting occurs when parasite-derived P. falciparum Erythrocyte Membrane Protein One (PfEMP1 on the surface of infected erythrocytes binds to human receptors on uninfected erythrocytes. PfEMP1 is a possible target for a vaccine to induce antibodies to inhibit rosetting and prevent severe malaria. METHODOLOGY/FINDINGS: We examined the vaccine potential of the six extracellular domains of a rosette-mediating PfEMP1 variant (ITvar9/R29var1 from the R29 parasite strain by immunizing rabbits with recombinant proteins expressed in E. coli. Antibodies raised to each domain were tested for surface fluorescence with live infected erythrocytes, rosette inhibition and phagocytosis-induction. Antibodies to all PfEMP1 domains recognized the surface of live infected erythrocytes down to low concentrations (0.02-1.56 µg/ml of total IgG. Antibodies to all PfEMP1 domains except for the second Duffy-Binding-Like region inhibited rosetting (50% inhibitory concentration 0.04-4 µg/ml and were able to opsonize and induce phagocytosis of infected erythrocytes at low concentrations (1.56-6.25 µg/ml. Antibodies to the N-terminal region (NTS-DBL1α were the most effective in all assays. All antibodies were specific for the R29 parasite strain, and showed no functional activity against five other rosetting strains. CONCLUSIONS/SIGNIFICANCE: These results are encouraging for vaccine development as they show that potent antibodies can be generated to recombinant PfEMP1 domains that will inhibit rosetting and induce phagocytosis of infected erythrocytes. However, further work is needed on rosetting mechanisms and cross-reactivity in field isolates to define a set of PfEMP1 variants that could induce functional antibodies against a broad range of P. falciparum rosetting parasites.

  11. Gobierno Corporativo y Calidad de la Información Contable: Evidencia Empírica

    Directory of Open Access Journals (Sweden)

    JUAN MONTERREY MAYORAL

    2008-06-01

    Full Text Available En el presente trabajo analizamos empíricamente los efectos de las actividades de Gobierno Corporativo sobre la calidad del resultado de las compañías cotizadas en el mercado español de capitales. Nuestros resultados han puesto de manifiesto una moderada influencia de las tareas desempeñadas por el grado de actividad del Consejo de Administración, que guarda una relación positiva y significativa con la calidad del resultado, pero no su tamaño y composición. Con relación al Comité de Auditoría, ninguna de las variables ha resultado ser estadísticamente significativa, y con respecto a la participación del equipo directivo en la propiedad de la firma, los resultados obtenidos indican cómo moderados niveles de propiedad gerencial aportan un efecto benéfico sobre la calidad contable, si bien a medida que su participación se eleva el efecto se invierte y se hace adverso. También hemos mostrado cómo la presencia de las familias fundadoras en el capital favorece la calidad contable, sin que hayamos obtenido evidencia de efecto alguno de la participación de tenedores de bloques significativos.This paper presents an empirical analysis of the impact of Corporate Governance practices on the quality of earnings reported by Spanish listed companies. Based on a sample of 136 non-financial firms over the period 2003-2005, we computed abnormal accruals based on Jones (1991 model as a proxy for earnings quality and experimental variables representing size, independence and activeness of the Board of Directors and the Audit Committee, CEO power concentration, board members’ compensation schemes and ownership structure. Our results suggest that earnings quality is slightly positively affected by the nature and intensiveness of the activities carried out by the Board, but has no relationship with its size and composition. None of the variables related to the Audit Committee showed a significant association with earnings quality. As for

  12. Spinal Cord Stimulation Provides Pain Relief with Improved Psychosocial Function: Results from EMP3OWER.

    Science.gov (United States)

    Rosenberg, Jason; Fabi, Alain; Candido, Kenneth; Knezevic, Nick; Creamer, Michael; Carayannopoulos, Alexios; Ghodsi, Abdi; Nelson, Christopher; Bennett, Matthew

    2016-12-01

    The EMP(3)OWER™ study evaluated spinal cord stimulation (SCS) safety and efficacy and the associated changes in psychosocial and functional outcomes. Upon informed consent and IRB approval, 620 eligible subjects were enrolled prior to SCS trial evaluation and were assessed at baseline, 3, 6 and 12 months post-implant. Patient-reported pain relief (PRP), numerical rating scale (NRS), satisfaction, quality of life (QOL), and pain disability index (PDI) were assessed at all follow-up visits while the pain catastrophizing scale (PCS), short form-36 (SF-36), short form-McGill pain questionnaire version 2 (SF-MPQ-2), and the state-trait anxiety inventory (STAI) were assessed at the 6- and 12-month follow-up visits. Device and/or procedure-related adverse events were also recorded and reported. Subjects reporting a PRP ≥ 50% were considered responders. Repeated measures analysis of variance (RMANOVA) examined the changes across time for all continuous measures. A total of 401 (71%) subjects received a permanent implant. Mean (±SD) patient-reported pain relief was 59.3% (±26.2), 59.2% (±28.9), and 58.2% (±32.0) at 3, 6, and 12 months, respectively. A majority of enrolled subjects were responders at 3 (75.5%), 6 (74.7%), and 12 months (69.7%). RMANOVA revealed a statistically significant change for NRS, PCS, PDI, SF-36, SF-MPQ-2, and STAI scores. At 3 months, the majority of subjects (85.7%) were either very satisfied or satisfied with their device, with similar results at 6 and 12 months. At 3 months, the majority of subjects (73.3%) reported greatly improved or improved QOL with similar results at 6 and 12 months. Spinal cord stimulation provided pain relief and significant improvement of patient psychological and functional outcome measures. © 2016 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  13. Search for the Giant Pulses Search for the Giant Pulses - an extreme phenomenon in radio pulsar emission

    CERN Document Server

    Kazantsev, A N

    2016-01-01

    Here we present results of our search for Giant Pulses(GPs) from pulsars of Northern Hemisphere. Our survey was carried out at a frequency of 111 MHz using the Large Phased Array (LPA) radio telescope. Up to now we have detected regular generation of strong pulses satisfying the criteria of GPs from 2 pulsars: B1133+16, B1237+25.

  14. El rol de las emociones positivas empáticas en el comportamiento social de los adolescentes

    OpenAIRE

    de la Vega, Noely; Oros, Laura Beatriz

    2015-01-01

    El objetivo del presente estudio fue analizar si las emociones positivas empáticas, simpatía y gratitud, influyen sobre el comportamiento social en los adolescentes. La muestra estuvo compuesta por 255 participantes de ambos sexos (109 mujeres y 146 varones), de entre 14 y 18 años de edad (M = 15.97; DE = 1.18), que asistían a diferentes instituciones educativas en la provincia de Buenos Aires. Para recabar la información se utilizaron: (a) el...

  15. PfEMP1 – A Parasite Protein Family of Key Importance in Plasmodium falciparum Malaria Immunity and Pathogenesis

    DEFF Research Database (Denmark)

    Hviid, Lars; Jensen, Anja T R

    2015-01-01

    to be a central element in the pathogenesis of the disease. It is mediated by the interaction of parasite ligands on the erythrocyte surface and a range of host receptor molecules in many organs and tissues. Among several proteins and protein families implicated in this process, the P. falciparum erythrocyte...... membrane protein 1 (PfEMP1) family of high-molecular weight and highly variable antigens appears to be the most prominent. In this chapter, we aim to provide a systematic overview of the current knowledge about these proteins, their structure, their function, how they are presented on the erythrocyte...

  16. El carácter empírico y lógico de la contabilidad

    OpenAIRE

    Scarano, Eduardo R.

    2009-01-01

    El objetivo de este artículo es argumentar acerca del carácter esencialmente empírico y científico de la contabilidad. Este punto de vista implica rechazar el carácter predominantemente normativo que posee la contabilidad, por lo menos, en Latinoamérica. Se considera que el normativismo de cualquier tipo es meramente secundario.La contabilidad es una disciplina científica, pero al carecer de leyes estrictas no constituye una ciencia básica, es una tecnología social.Se mostrará que tiene una e...

  17. El enfoque empírico-inductivo y los problemas de la investigación social en Venezuela

    Directory of Open Access Journals (Sweden)

    Sorayda Rincón

    2001-05-01

    Full Text Available El hombre históricamente ha estudiado el conocimiento humano, buscando diferenciar el conocimiento vulgar del conocimiento científico. Existen diversas formas de producir el conocimiento científico que comienzan a formalizarse antes del siglo XX y en el siglo XX. En el siglo XX uno de los enfoques más importantes para la producción de conocimiento fue el enfoque empírico inductivo (positivismo que aún hoy día tiene gran influencia en las ciencias sociales en Venezuela. Es por ello, que la presente investigación tiene como propósito disertar de manera teórica acerca del enfoque empírico inductivo, su influencia y limitaciones en la producción del conocimiento científico en las ciencias sociales; así como, conocer y describir la opinión de los profesores universitarios sobre el mismo y su utilidad en las asesorías de tesis de pre-grado y postgrado. Para lograr este último objetivo, se utilizó un sondeo de opinión a los profesores universitarios sobre los criterios fundamentales del enfoque empírico inductivo, a saber: criterio de demarcación, inducción probabilística, lenguaje lógico y unificación de la ciencia. Los datos obtenidos del sondeo de opinión se tabularon a través de estadística descriptiva, con análisis de frecuencia. Obteniendo como conclusión que este enfoque es aún utilizado por muchos investigadores en el área de lo social, que a pesar que en el discurso muchos niegan su uso, en las asesorías de tesis lo promueven, orientando las mismas hacia un referente empírico y generalizando a partir de probabilidades y estadísticas

  18. Antigenic variation and the genetics and epigenetics of the PfEMP1 erythrocyte surface antigens in Plasmodium falciparum malaria

    DEFF Research Database (Denmark)

    Arnot, David E; Jensen, Anja T R

    2011-01-01

    do become immune to P. falciparum malaria, but this is a slow process requiring multiple disease episodes which many, particularly young children, do not survive. Adult survivors are immune to the symptoms of malaria, and unless pregnant, can control the growth of most or all new inoculations....... Sterile immunity is not achieved and chronic parasitization of apparently healthy adults is the norm. In this article, we analyse the best understood malaria "antigenic variation" system, that based on Plasmodium falciparum's PfEMP1-type cytoadhesion antigens, and critically review recent literature...

  19. Altered expression of CLC, DSG3, EMP3, S100A2, and SLPI in corneal epithelium from keratoconus patients

    DEFF Research Database (Denmark)

    Nielsen, Kim; Heegaard, Steffen; Vorum, Henrik

    2005-01-01

    PURPOSE: This investigation was designed to determine whether the five genes, CLC, DSG3, EMP3, S100A2 and SLPI, are differentially expressed in keratoconus, as indicated from another study. METHODS: Gene expression was monitored using quantitative real-time PCR on 14 keratoconus samples and 16...... differentially expressed in keratoconus (P ... SNPs (rs374185 and rs384138) were observed in the CLC gene, each with an allele frequency of 68%. No other mutations were detected. CONCLUSIONS: The five genes, and three of the encoded proteins, were shown differentially expressed between a group of keratoconus patients and a reference group using...

  20. El carácter empírico y lógico de la contabilidad

    OpenAIRE

    Scarano, Eduardo R.

    2009-01-01

    El objetivo de este artículo es argumentar acerca del carácter esencialmente empírico y científico de la contabilidad. Este punto de vista implica rechazar el carácter predominantemente normativo que posee la contabilidad, por lo menos, en Latinoamérica. Se considera que el normativismo de cualquier tipo es meramente secundario.La contabilidad es una disciplina científica, pero al carecer de leyes estrictas no constituye una ciencia básica, es una tecnología social.Se mostrará que tiene una e...

  1. Relaciones Empíricas Entre Empresas y Bancos. Una Visión Financiera Relaciones Empíricas Entre Empresas y Bancos. Una Visión Financiera

    Directory of Open Access Journals (Sweden)

    Andrea Escobar Grisales

    2003-12-01

    Full Text Available The research group on economics and business carried out the project "theoretical and empiricalaspects of firms – banks" relationship. The general objective was developing an investigationabout the channels and variables through which a relationship is establish between firms returnand performance, on one hand, and banks´ solvency and returns´ on the other.The main purpose of this paper is discussing the importance of firms´ financial management onfinancial sector credit policy establishment.El Grupo de Estudios en Economía y Empresa desarrolló, durante 2003, el proyecto Aspectosteóricos y empíricos de la relación empresas-bancos, cuyo objetivo general fue realizar una indagación sobre los canales y las variables a través de los cuales se establece una relación entre la rentabilidad y desempeño de las empresas, con la solidez y rentabilidad de los bancos (con datos de la economía colombiana para el lapso 1995-2000: para ello, se realizaron dos ejercicios, uno de carácter estadístico y otro de análisis financiero. El propósito de este artículo es presentar, en detalle, el análisis financiero de las relaciones empíricas entre bancos y empresas del sector real.

  2. Fatores de impacto na Atitude e na Intenção de uso do M-learning: um teste empírico

    Directory of Open Access Journals (Sweden)

    Renata Kurtz

    Full Text Available Este artigo apresenta os resultados de uma pesquisa empírica em que se propõe um modelo para avaliar a atitude e a intenção de uso do mobile-learning(m-learning por estudantes do ensino superior de um curso de administração baseado na teoria do flow, no Modelo de Aceitação de Tecnologia e na Teoria do Comportamento Planejado. A partir deste arcabouço teórico elaborou-se uma atividade prática envolvendo o uso de dispositivos com tecnologia móvel digital (celulares em que se buscou aplicar o m-learning para estimular os estudantes a unir a teoria à prática. Em seguida, foi feita uma survey respondida por 235 universitários, em que se buscou compreender os fatores que influenciam a atitude e a intenção de uso do m-learning para o processo de ensino-aprendizagem. Os dados coletados foram tratados por meio de equações estruturais e os resultados mostraram fortes efeitos positivos dos fatores utilidade, diversão e controle do comportamento percebidos pelos estudantes na atitude e na intenção de uso do m-learning. Por fim, verificou-se que a atividade de uso prático realizada com os alunos mostrou que o uso do celular em uma atividade acadêmica pôde proporcionar a construção e o entendimento deles das relações entre a teoria apresentada e a prática em um ambiente real.

  3. La comprensión de la solidaridad. Análisis de estudios empíricos

    Directory of Open Access Journals (Sweden)

    Yicel Nayrobis Giraldo

    2015-01-01

    Full Text Available En este escrito analizamos una serie de estudios empíricos sobrela solidaridad realizados en distintos países de América Latina. Se trata de trabajos en los queconvergen diversas disciplinas de las ciencias sociales, la educación y las humanidades, realizados enlos últimos catorce años. La base del análisis es de carácter documental y el corpus estuvo integradopor 39 textos (artículos, libros, informes de carácter investigativo. De ese modo, identificamostres tendencias en el abordaje investigativo de la solidaridad: 1. Como acción dirigida a quien esconsiderado vulnerable; 2. Como espacio de mediación experta; y 3. Como práctica social orientadaa la superación de la injusticia y la desigualdad. Finalmente, el análisis de estos estudios empíricospermite derivar una serie de reflexiones sobre la solidaridad en los tiempos actuales, y una propuestageneral para la formulación de un programa de investigación en este campo.

  4. La comprensión de la solidaridad. Análisis de estudios empíricos

    Directory of Open Access Journals (Sweden)

    Yicel Nayrobis Giraldo

    2015-07-01

    Full Text Available (descriptivo: En este escrito analizamos una serie de estudios empíricos sobre la solidaridad realizados en distintos países de América Latina. Se trata de trabajos en los que convergen diversas disciplinas de las ciencias sociales, la educación y las humanidades, realizados en los últimos catorce años. La base del análisis es de carácter documental y el corpus estuvo integrado por 39 textos (artículos, libros, informes de carácter investigativo. De ese modo, identificamos tres tendencias en el abordaje investigativo de la solidaridad: 1. Como acción dirigida a quien es considerado vulnerable; 2. Como espacio de mediación experta; y 3. Como práctica social orientada a la superación de la injusticia y la desigualdad. Finalmente, el análisis de estos estudios empíricos permite derivar una serie de reflexiones sobre la solidaridad en los tiempos actuales, y una propuesta general para la formulación de un programa de investigación en este campo.

  5. Empirical validation of CAPM Validación empírica del modelo CAPM para Colombia 2003-2010

    Directory of Open Access Journals (Sweden)

    Maribel Serna Rodriguez

    2012-06-01

    Full Text Available This paper pretends to show empirical evidence of the CAPM model of Sharpe-Lintner (1964 for Colombia from 2003 to 2010, whose validation is carried out using the method of Black, Jensen and Scholes (1972 but introducing certain methodological econometric type changes associated to the requirements imposed by the used sample. Specifically, we found no empirical evidence to reject the CAPM for the Colombian economyin the period under analysis.En este trabajo se pretende mostrar una evidencia empírica para Colombia, desde el año 2003 hasta el 2010, del modelo CAPM de Sharpe –Lintner (1964, validación que se lleva a cabo utilizando el procedimiento de Black, Jensen y Scholes (1972 pero introduciendo ciertos cambios metodológicos de índole econométrico asociados a las necesidades que impone la muestra utilizada. Específicamente, se encontró que no hay evidencia empírica para rechazar el modelo CAPM para la economía colombiana en el período objeto de análisis.

  6. PulseSoar

    Energy Technology Data Exchange (ETDEWEB)

    Carter, P.; Peglow, S.

    1992-07-21

    This paper is an introduction to the PulseSoar concept. PulseSoar is a hypervelocity airplane that uses existing airport facilities and current technologies to fly at the very edge of space. It will be shown that PulseSoar can fly between any two points on the globe in less than two hours with fuel efficiency exceeding current state of the art commercial airliners. In addition, it will be shown that PulseSoar avoids environmental issues concerning the ozone layer and sonic booms because of its unique flight profile. All of this can be achieved with current technology. PulseSoar does not require the development of enabling technology. It is a concept which can be demonstrated today. The importance of this idea goes beyond the technical significance`s of PulseSoar in terms of feasibility and performance. PulseSoar could provide a crucial economic advantage to America`s largest export market: commercial aircraft. PulseSoar is a breakthrough concept for addressing the emerging markets of long range and high speed aircraft. Application of PulseSoar to commercial transport could provide the US Aerospace industry a substantial lead in offering high speed/long range aircraft to the world`s airlines. The rapid emergence of a US developed high speed aircraft could also be important to our competitiveness in the Pacific Rim and South American economies. A quick and inexpensive demonstration vehicle is proposed to bang the concept to reality within two years. This discussion will address all the major technical subjects encompassed by PulseSoar and identifies several near-term, and low risk, applications which may be further explored with the initial demonstration vehicle. What is PulseSoar? PulseSoar could enable high speed, high altitude and long range flight without many of the difficulties encountered by traditional hypersonic vehicles.

  7. Una Evaluación Empírica del Fondo de Comercio

    Directory of Open Access Journals (Sweden)

    Manuel Larrán Jorge

    2000-06-01

    Full Text Available En el presente trabajo se analizará bajo una perspectiva empírica uno de los activos empresariales más controvertidos como es el fondo de comercio. Dicha controversia no se materializa únicamente en su definición, sino también en su cuantificación y tratamiento contable, dando lugar en los últimos años a una importante línea de investigación centrada en la relevancia valorativa del fondo de comercio en particular y de los intangibles en general. Nuestro trabajo plantea un doble objetivo: en primer lugar, estudiar los efectos económicos ocasionados por tratamientos contables alternativos del fondo de comercio, mediante el análisis de la sensibilidad de determinados ratios ante las diversas opciones contables existentes; y, en segundo término, verificar la relevancia valorativa del fondo de comercio desde la perspectiva del mercado de capitales. Para la realización del trabajo hemos utilizado información contable de grupos de empresas españoles e información bursátil correspondiente a la dominante para los ejercicios 1991-1997.Las conclusiones básicas obtenidas se centran en que el análisis empresarial basado en ratios puede verse afectado por el tratamiento contable a que se haya sometido al fondo de comercio. Por otra parte, se obtienen evidencias del incremento en el tiempo de la relevancia valorativa del fondo de comercio en el mercado bursátil español, así como de la dependencia de dicha relevancia de ciertos factores contextuales como el nivel de resultados, la participación del fondo de comercio en el total de activo, etc. This paper analyses from an empirical perspective one of the most controversial of company assets, namely goodwill. The controversial nature of goodwill lies not only in its definition but also in its quantification and accounting treatment, giving rise in recent years to an important line of research centred on the value relevance of goodwill in particular and intangibles in general.The paper has

  8. 水平极化EMP模拟器参考场位置的选取%Selection of Position for Reference Field of Horizontally Polarized EMP Simulator

    Institute of Scientific and Technical Information of China (English)

    陈向跃; 孙蓓云; 刘顺坤; 孙东阳

    2009-01-01

    水平极化EMP模拟器是开展大型系统电磁脉冲效应试验的典型装置,参考场是效应试验中最重要的测量参数.分析了地面和受试对象对辐射波电场环境的影响,对水平极化EMP模拟器参考场位置的选取给出建议.%Horizontally polarized EMP simulator is a typical facility to progress researching EMP effect of complex system. The reference field is the most important parameter. The effect of the electromagnetic environment caused by ground and equipment under test (EUT) is researched. Some suggestions about selection of position for reference field of horizontally polarized EMP simulators are put forward.

  9. Structural Studies on Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Malaria Antigens Using Small Angle X-Ray Scattering (SAXS)

    DEFF Research Database (Denmark)

    Christoffersen, Stig

    against placental malaria, VAR2CSA was studied extensively. By the use of SAXS on multiple truncated VAR2CSA constructs it was possible to combine the acquired information and present a structural model for the DBL and CIDR domain arrangement in VAR2CSA. This work was published in Journal of Biological...... symptoms and vaccine research is focused on trying to mimic or advance this immune acquisition. Immunity is primarily caused by acquisition of antibodies directed against a family of Plasmodium protein antigens called PfEMP1s located on the surface of infected erythrocytes. The PfEMP1 proteins are adhesive...... knowledge for these proteins is required. During the time course of this PhD thesis I have studied a number of PfEMP1 proteins using the SAXS technique. This biophysical technique has gained widespread attention during the past decade due to scientific and computational developments. SAXS is X...

  10. Pulse Tube Refrigerator

    Science.gov (United States)

    Matsubara, Yoichi

    The pulse tube refrigerator is one of the regenerative cycle refrigerators such as Stirling cycle or Gifford-McMahon cycle which gives the cooling temperature below 150 K down to liquid helium temperature. In 1963, W. E. Gifford invented a simple refrigeration cycle which is composed of compressor, regenerator and simple tube named as pulse tube which gives a similar function of the expander in Stirling or Gifford-McMahon cycle. The thermodynamically performance of this pulse tube refrigerator is inferior to that of other regenerative cycles. In 1984, however, Mikulin and coworkers made a significant advance in pulse tube configuration called as orifice pulse tube. After this, several modifications of the pulse tube hot end configuration have been developed. With those modifications, the thermodynamic performance of the pulse tube refrigerator became the same order to that of Stirling and Gifford-McMahon refrigerator. This article reviews the brief history of the pulse tube refrigerator development in the view point of its thermodynamically efficiency. Simplified theories of the energy flow in the pulse tube have also been described.

  11. Ultrashort Laser Pulse Phenomena

    CERN Document Server

    Diels, Jean-Claude

    2006-01-01

    Ultrashort Laser Pulse Phenomena, 2e serves as an introduction to the phenomena of ultra short laser pulses and describes how this technology can be used to examine problems in areas such as electromagnetism, optics, and quantum mechanics. Ultrashort Laser Pulse Phenomena combines theoretical backgrounds and experimental techniques and will serve as a manual on designing and constructing femtosecond (""faster than electronics"") systems or experiments from scratch. Beyond the simple optical system, the various sources of ultrashort pulses are presented, again with emphasis on the basic

  12. Strong and superstrong pulsed magnetic fields generation

    CERN Document Server

    Shneerson, German A; Krivosheev, Sergey I

    2014-01-01

    Strong pulsed magnetic fields are important for several fields in physics and engineering, such as power generation and accelerator facilities. Basic aspects of the generation of strong and superstrong pulsed magnetic fields technique are given, including the physics and hydrodynamics of the conductors interacting with the field as well as an account of the significant progress in generation of strong magnetic fields using the magnetic accumulation technique. Results of computer simulations as well as a survey of available field technology are completing the volume.

  13. 恶性疟原虫毒性蛋白PfEMP1的作用与运输%Pathologic role of PfEMP1 and its trafficking in host cells

    Institute of Scientific and Technical Information of China (English)

    贾默稚; 吴伟; 鲁凤民

    2011-01-01

    One of the obvious modifications of Plasmodium falciparuni-infected erythrocytes is the development of thousands of knobs. The virulence protein, P. falciparum erythrocyte membrane protein 1 (PfEMPl), is anchored on the outer face of erythrocytes via the knobs and mediates the adhesion of infected erythrocytes to the endothelial cells, thereby avoiding splenic clearance and resulting in host organ dysfunction due to the accumulation of infected erythrocytes within microvasculature. The PfEMPl expressed by the parasite's genome is exported to the parasitophorous vacuole in accordance with the specific domains of the protein. Since mature erythrocytes lack subcelluar organelles, the transporta-tion of parasite proteins to the outside of the host cell depends on the parasite's protein trafficking. Maurer's clefts are se-cretory organelles that play an important role in the export of PfEMPl from PV to the host cytosol and membrane.%受恶性疟原虫感染的宿主红细胞会进行细胞重建,其中最明显的改变就是受染红细胞表面出现很多疣状突起(knob).恶性疟红细胞膜相关蛋白1(PfEMP1)是疟原虫产生的毒性蛋白;这种蛋白通过受染红细胞表面的疣状突起被锚定在红细胞表面,介导红细胞与宿主内皮细胞受体结合,从而使恶性疟原虫能够逃避宿主的清除,并因阻塞作用致宿主脏器功能受损.PfEMP1由疟原虫基因组编码产生,通过其自身的一些特殊结构域将PfEMP1输送至包绕恶性疟原虫的纳虫空泡.由于红细胞没有亚细胞器,因此疟原虫必须建立自己的蛋白运输通路方可将虫体蛋白运至宿主细胞表面.受染红细胞胞质出现的茂氏裂褶是一种分泌细胞器,它将毒性蛋白由纳虫空泡运至红细胞膜表面.

  14. Antibody reactivity to conserved linear epitopes of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)

    DEFF Research Database (Denmark)

    Staalsø, T; Khalil, E A; Elhassan, I M;

    1998-01-01

    The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of protein antigens are involved in adhesion of P. falciparum infected erythrocytes to the capillary endothelium of the host. Antibodies to variable regions of these proteins, measured by agglutination, correlates with clini......The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of protein antigens are involved in adhesion of P. falciparum infected erythrocytes to the capillary endothelium of the host. Antibodies to variable regions of these proteins, measured by agglutination, correlates...

  15. Economía de la familia: una aplicación empírica del modelo unitario para colombia

    OpenAIRE

    2009-01-01

    Serrano, Edgar David. "Economía de una Familia: Una Aplicación Empírica del Modelo Unitario para Colombia". Cuadernos de Economía, V. XXII, n. 38, Bogotá, 2003, páginas 151-177.

    El articulo expone los elementos sustanciales del modelo unitario en la perspectiva de Samuelson (Concenso) (1956), con el proposito de discutir la fortaleza teórica de los supuestos de preferencias de grupo y el fondo de ingresos común. El desarrollo del modelo empírico aplicado en esta vía...

  16. Análisis del nivel de implantación de la calidad : estudio empírico en el sector de alojamiento turístico

    OpenAIRE

    Álvarez García, José

    2012-01-01

    La importancia de la calidad para las empresas turísticas como estrategia para obtener ventajas competitivas frente a los competidores, nos hace comprender la necesaria investigación, tanto teórica como empírica, que ayude a desarrollar un marco teórico-práctico para las empresas del sector de alojamiento turístico que deseen implantar la calidad para poder sobrevivir en un mundo altamente competitivo. En esta tesis se realizó un estudio empírico en 186 empresas de alojamiento turístico ...

  17. Analysis of the damage threshold of the GaAs pseudomorphic high electron mobility transistor induced by the electromagnetic pulse

    Science.gov (United States)

    Xi, Xiao-Wen; Chai, Chang-Chun; Liu, Yang; Yang, Yin-Tang; Fan, Qing-Yang; Shi, Chun-Lei

    2016-08-01

    An electromagnetic pulse (EMP)-induced damage model based on the internal damage mechanism of the GaAs pseudomorphic high electron mobility transistor (PHEMT) is established in this paper. With this model, the relationships among the damage power, damage energy, pulse width and signal amplitude are investigated. Simulation results show that the pulse width index from the damage power formula obtained here is higher than that from the empirical formula due to the hotspot transferring in the damage process of the device. It is observed that the damage energy is not a constant, which decreases with the signal amplitude increasing, and then changes little when the signal amplitude reaches up to a certain level. Project supported by the National Basic Research Program of China (Grant No. 2014CB339900) and the Open Fund of Key Laboratory of Complex Electromagnetic Environment Science and Technology, China Academy of Engineering Physics (CAEP) (Grant No. 2015-0214.XY.K).

  18. Pulsed Plasma Electron Sources

    Science.gov (United States)

    Krasik, Yakov

    2008-11-01

    Pulsed (˜10-7 s) electron beams with high current density (>10^2 A/cm^2) are generated in diodes with electric field of E > 10^6 V/cm. The source of electrons in these diodes is explosive emission plasma, which limits pulse duration; in the case E Hadas and Ya. E. Krasik, Europhysics Lett. 82, 55001 (2008).

  19. PULSE AMPLITUDE DISTRIBUTION RECORDER

    Science.gov (United States)

    Cowper, G.

    1958-08-12

    A device is described for automatica1ly recording pulse annplitude distribution received from a counter. The novelty of the device consists of the over-all arrangement of conventional circuit elements to provide an easy to read permanent record of the pulse amplitude distribution during a certain time period. In the device a pulse analyzer separates the pulses according to annplitude into several channels. A scaler in each channel counts the pulses and operates a pen marker positioned over a drivable recorder sheet. Since the scalers in each channel have the sanne capacity, the control circuitry permits counting of the incoming pulses until one scaler reaches capacity, whereupon the input is removed and an internal oscillator supplies the necessary pulses to fill up the other scalers. Movement of the chart sheet is initiated wben the first scaler reaches capacity to thereby give a series of marks at spacings proportional to the time required to fill the remaining scalers, and accessory equipment marks calibration points on the recorder sheet to facilitate direct reading of the number of external pulses supplied to each scaler.

  20. Pulse consumption in Canadian adults influences nutrient intakes.

    Science.gov (United States)

    Mudryj, Adriana N; Yu, Nancy; Hartman, Terryl J; Mitchell, Diane C; Lawrence, Frank R; Aukema, Harold M

    2012-08-01

    Pulses (dry beans, peas, lentils) are nutrient-dense foods that are recommended as good choices in either the vegetable or meat and alternative food groups in Canada's Food Guide. To examine the prevalence and the effect of pulse consumption on nutrient intake in Canadian adults ( ≥ 19 years), we analysed cross-sectional data (n 20,156) from the 2004 Canadian Community Health Survey, Cycle 2·2. Participants were divided into non-consumers and quartiles of pulse intake. Sample weights were applied and logistic regression analysis was used to explore the association of nutrient intakes and pulse consumption, with cultural background, sex, age and economic status included as covariates. On any given day, 13 % of Canadians consume pulses, with the highest consumption in the Asian population. The pulse intake of consumers in the highest quartile was 294 (se 40) g/d and, compared with non-consumers, these individuals had higher intakes of carbohydrate, fibre and protein. As well, the micronutrient intake of pulse consumers was enhanced, resulting in fewer individuals who were below the estimated average requirement for thiamin, vitamin B6, folate, Fe, Mg, P and Zn, compared with non-consumers. Although pulses are generally low in Na, its intake also was higher in pulse consumers. Among the higher quartiles of pulse consumers, fruit and vegetable intake was one serving higher. These data indicate that pulse consumption supports dietary advice that pulses be included in healthful diets. Further studies elucidating the sources of increased Na in pulse consumers will be necessary so that dietary advice to increase consumption of pulses will maximise their nutritional benefits.

  1. SAPIENS Memo 11. Electromagnetic characteristics of the conical transmission-line EMP simulator SAPIENS

    Science.gov (United States)

    Garmland, S.

    1986-02-01

    A bounded wave electromagnetic pulse simulator was tested. Electric field measurements reveal deviations from an ideal curve shape. The largest deviation is traced to the termination of the simulator antenna. High-frequency components radiate through the termination and low-frequency ones are terminated by a resistive load. The space in between, where the wavelength is equal to the dimension of the termination, presents difficulties. Here, the inductance of the termination is crucial. By increasing the diameter of the wires connecting the resistors of the termination, the inductance may be reduced. It is shown how TEM-reflections from the termination can be diminished from 10% to 2% by replacing the wires with cylinders made of chicken-wire. The electric and the magnetic fields measured inside and outside the simulator confirm the good qualities of the simulator design regarding the antenna bandwidth, the field impedance, homogeneity, and polarization.

  2. Pulsed electron beam precharger

    Energy Technology Data Exchange (ETDEWEB)

    Finney, W.C. (ed.); Shelton, W.N.

    1990-01-01

    Florida State University is investigating the concept of pulsed electron beams for fly ash precipitation. This report describes the results and data on three of the subtasks of this project and preliminary work only on the remaining five subtasks. Described are the modification of precharger for pulsed and DC energization of anode; installation of the Q/A measurement system; and modification and installation of pulsed power supply to provide both pulsed and DC energization of the anode. The other tasks include: measurement of the removal efficiency for monodisperse simulated fly ash particles; measurement of particle charge; optimization of pulse energization schedule for maximum removal efficiency; practical assessment of results; and measurement of the removal efficiency for polydisperse test particles. 15 figs., 1 tab. (CK)

  3. Pulse Distortion in Saturated Fiber Optical Parametric Chirped Pulse Amplification

    DEFF Research Database (Denmark)

    Lali-Dastjerdi, Zohreh; Da Ros, Francesco; Rottwitt, Karsten

    2012-01-01

    Fiber optical parametric chirped pulse amplification is experimentally compared for different chirped pulses in the picosecond regime. The amplified chirped pulses show distortion appearing as pedestals after recompression when the amplifier is operated in saturation.......Fiber optical parametric chirped pulse amplification is experimentally compared for different chirped pulses in the picosecond regime. The amplified chirped pulses show distortion appearing as pedestals after recompression when the amplifier is operated in saturation....

  4. Evicencia Empírica en Torno al Estudio del Factor Tamaño cono Condicionante Empresarial

    OpenAIRE

    María Elena Gómez Miranda; Lázaro Rodríguez Ariza

    2004-01-01

    En este trabajo presentamos las principales conclusiones obtenidas a través de la realización de un estudio empírico, con el que contrastamos la hipótesis del condicionamiento empresarial por razón de su dimensión. La investigación se ha realizado a través de la aplicación de diversas técnicas de análisis multivariable, concretamente el análisis factorial, cluster y discriminante, sobre la información relativa a una muestra integrada por 6.600 empresas. Para la definición del tamaño empresari...

  5. El modelo de ciclo y crecimiento de Richard Goodwin. Una evaluación empírica para Colombia

    Directory of Open Access Journals (Sweden)

    Moreno R. Álvaro Martín

    2002-12-01

    Full Text Available

    El objetivo del presente trabajo es exponer y evaluar la
    hipótesis del crecimiento cíclico de Richard Goodwin. Se
    utilizan datos colombianos para contrastar los supuestos del
    modelo. Se encontró que a nivel cualitativo, la dinámica de
    las variables de estado en el espacio de fases muestra cierta
    correspondencia con las predicciones teóricas, al menos
    para dos períodos: 1957-1966 y 1968-1974. Los resultados
    cuantitativos rechazan los supuestos del modelo y los modelos
    empíricos no describen el verdadero proceso generador de
    los datos.

  6. Sustentabilidade e responsabilidade social: proposta de modelo de diagnóstico socioambiental baseada em pesquisa empírica

    Directory of Open Access Journals (Sweden)

    Takeshy Tachizawa

    2009-12-01

    Full Text Available O trabalho apresenta uma arquitetura de dados socioambientais para diagnóstico das organizações em termos de sustentabilidade econômica. É proposto um modelo de base de dados de indicadores socioambientais, fundamentado em pesquisa empírica, desenvolvida pelo método grounded theory. A ênfase da grounded theory é o aprendizado a partir dos dados (interativa e indutiva, e não a partir de uma visão teórica existente (dedutiva. Tais indicadores, além de refletir o estágio de sustentabilidade em que se encontra a empresa analisada, subsidiariam o mapeamento socioambiental dos diferentes segmentos econômicos do universo empresarial brasileiro. A arquitetura, estruturada com o suporte de recursos das tecnologias da informação possibilitaria o planejamento de decisões inerentes à gestão socioambiental de sua cadeia produtiva.

  7. La burocracia mexicana como actor: construyendo las bases para su análisis empírico

    OpenAIRE

    Gault, David Arellano

    2009-01-01

    Empíricamente, el actor burocrático ha sido poco estudiado en México.  A la luz del dominio de un partido, en la era contemporánea este actor, en la escala federal, fue considerado básicamente un apéndice, una maquinaria obediente al régimen. La teoría de las camarillas ha perdurado desde entonces. Sin embargo, esta teoría es poco sostenible considerando lo que ha sucedido políticamente en los últimos años. Los servidores públicos que no pertenecen a una camarilla son una gran mayoría, como l...

  8. The Triassic reworking of the Yunkai massif (South China): EMP monazite and U-Pb zircon geochronologic evidence

    Science.gov (United States)

    Chen, Cheng-Hong; Liu, Yung-Hsin; Lee, Chi-Yu; Sano, Yuji; Zhou, Han-Wen; Xiang, Hua; Takahata, Naoto

    2017-01-01

    Geohistory of the Yunkai massif in South China Block is important in understanding the geodynamics for the build-up of this block during the Phanerozoic orogenies. To investigate this massif, we conduct EMP monazite and U-Pb zircon geochronological determinations on mineral inclusions and separate for seventeen samples in four groups, representing metamorphic rocks from core domain, the Gaozhou Complex (amphibolite facies, NE-striking) and the Yunkai Group (greenschist facies, NW-striking) of this massif and adjacent undeformed granites. Some EMP monazite ages are consistent with the NanoSIMS results. Monazite inclusions, mostly with long axis parallel to the cleavage of platy and elongated hosts, give distinguishable age results for NW- and NE-trending deformations at 244-236 Ma and 236-233 Ma, respectively. They also yield ages of 233-230 Ma for core domain gneissic granites and 232-229 Ma for undefomed granites. Combining U-Pb zircon ages of the same group, 245 Ma and 230 Ma are suggested to constrain the time of two phases of deformation. Aside from ubiquity of Triassic ages in studied rocks, ages of detrital monazite in the meta-sandstone match the major U-Pb zircon age clusters of the metamorphic rock that are largely concentrated at Neoproterozoic (1.0-0.9 Ga) and Early Paleozoic (444-431 Ma). Based on these geochronological data, Triassic is interpreted as representing the time for recrystallization of these host minerals on the Early Paleozoic protolith, and the also popular Neoproterozoic age is probably inherited. With this context, Yunkai massif is regarded as a strongly reactivated Triassic metamorphic terrain on an Early Paleozoic basement which had incorporated sediments with Neoproterozoic provenances. Triassic tectonic evolution of the Yunkai massif is suggested to have been controlled by converging geodynamics of the South China and Indochina Blocks as well as mafic magma emplacement related to the Emeishan large igneous province (E-LIP).

  9. El efecto del posicionamiento en la lealtad del cliente: Un análisis empírico para el caso de Iberdrola

    OpenAIRE

    Forcada Sainz, Francisco Javier; Hartmann, Patrick; Apaolaza Ibáñez, Vanesa

    2002-01-01

    [ES] En el presente trabajo se analiza la relación causal entre los conceptos de fidelidad del cliente y posicionamiento. Concretamente, se estudia el efecto diferenciado del posicionamiento percibido de una empresa en la lealtad de sus clientes, comprobando empíricamente dicha relación para el caso de Iberdrola.

  10. Contramedidas em segurança da informação e vulnerabilidade cibernética: evidência empírica de empresas brasileiras

    National Research Council Canada - National Science Library

    Igor Siqueira Cortez; Luis Claudio Kubota

    2013-01-01

    ... ou não medidas de segurança da informação. No presente estudo foi desenvolvida uma avaliação empírica desse fenômeno no Brasil. Modelos logit e probit ordenado foram desenvolvidos como forma de avaliar os efeitos sobre a probabilidade...

  11. α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes

    DEFF Research Database (Denmark)

    Stevenson, Liz; Laursen, Erik; Cowan, Graeme J;

    2015-01-01

    Rosetting, the adhesion of Plasmodium falciparum-infected erythrocytes to uninfected erythrocytes, involves clonal variants of the parasite protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) and soluble serum factors. While rosetting is a well-known phenotypic marker of parasites......-macroglobulin (α2M), which is both required and sufficient for rosetting mediated by the PfEMP1 protein HB3VAR06 and some other rosette-mediating PfEMP1 proteins. We map the α2M binding site to the C terminal end of HB3VAR06, and demonstrate that α2M can bind at least four HB3VAR06 proteins, plausibly....... Together, our results are evidence that P. falciparum parasites exploit α2M (and IgM) to expand the repertoire of host receptors available for PfEMP1-mediated IE adhesion, such as the erythrocyte carbohydrate moieties that lead to formation of rosettes. It is likely that this mechanism also affects IE...

  12. Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites

    DEFF Research Database (Denmark)

    Sleebs, Brad E; Lopaticki, Sash; Marapana, Danushka S;

    2014-01-01

    PEXEL cleavage occurs cotranslationaly, similar to signal peptidase. Treatment of P. falciparum-infected erythrocytes with the inhibitor caused dose-dependent inhibition of PEXEL processing as well as protein export, including impaired display of the major virulence adhesin, PfEMP1, on the erythrocyte...

  13. Antibodies against PfEMP1, RIFIN, MSP3 and GLURP Are Acquired during Controlled Plasmodium falciparum Malaria Infections in Naive Volunteers.

    NARCIS (Netherlands)

    Turner, L.; Wang, C.W.; Lavstsen, T.; Mwakalinga, S.B.; Sauerwein, R.W.; Hermsen, C.C.; Theander, T.G.

    2011-01-01

    Antibodies to polymorphic antigens expressed during the parasites erythrocytic stages are important mediators of protective immunity against P. falciparum malaria. Therefore, polymorphic blood stage antigens like MSP3, EBA-175 and GLURP and variant surface antigens PfEMP1 and RIFIN are considered

  14. Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

    DEFF Research Database (Denmark)

    Lennartz, Frank; Adams, Yvonne; Bengtsson, Anja

    2017-01-01

    Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display parasite proteins of the PfEMP1 family that bind various endothelial receptors. Despite the importance of cerebral malaria,...

  15. α2-macroglobulin can crosslink multiple Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) molecules and may facilitate adhesion of parasitized erythrocytes

    DEFF Research Database (Denmark)

    Stevenson, Liz; Laursen, Erik; Cowan, Graeme J;

    2015-01-01

    Rosetting, the adhesion of Plasmodium falciparum-infected erythrocytes to uninfected erythrocytes, involves clonal variants of the parasite protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) and soluble serum factors. While rosetting is a well-known phenotypic marker of parasites......-macroglobulin (α2M), which is both required and sufficient for rosetting mediated by the PfEMP1 protein HB3VAR06 and some other rosette-mediating PfEMP1 proteins. We map the α2M binding site to the C terminal end of HB3VAR06, and demonstrate that α2M can bind at least four HB3VAR06 proteins, plausibly....... Together, our results are evidence that P. falciparum parasites exploit α2M (and IgM) to expand the repertoire of host receptors available for PfEMP1-mediated IE adhesion, such as the erythrocyte carbohydrate moieties that lead to formation of rosettes. It is likely that this mechanism also affects IE...

  16. α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes

    DEFF Research Database (Denmark)

    Stevenson, Liz; Laursen, Erik; Cowan, Graeme J;

    2015-01-01

    Rosetting, the adhesion of Plasmodium falciparum-infected erythrocytes to uninfected erythrocytes, involves clonal variants of the parasite protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) and soluble serum factors. While rosetting is a well-known phenotypic marker of parasites...

  17. RF Pulsed Heating

    Energy Technology Data Exchange (ETDEWEB)

    Pritzkau, David P.

    2002-01-03

    RF pulsed heating is a process by which a metal is heated from magnetic fields on its surface due to high-power pulsed RF. When the thermal stresses induced are larger than the elastic limit, microcracks and surface roughening will occur due to cyclic fatigue. Pulsed heating limits the maximum magnetic field on the surface and through it the maximum achievable accelerating gradient in a normal conducting accelerator structure. An experiment using circularly cylindrical cavities operating in the TE{sub 011} mode at a resonant frequency of 11.424 GHz is designed to study pulsed heating on OFE copper, a material commonly used in normal conducting accelerator structures. The high-power pulsed RF is supplied by an X-band klystron capable of outputting 50 MW, 1.5 {micro}s pulses. The test pieces of the cavity are designed to be removable to allow testing of different materials with different surface preparations. A diagnostic tool is developed to measure the temperature rise in the cavity utilizing the dynamic Q change of the resonant mode due to heating. The diagnostic consists of simultaneously exciting a TE{sub 012} mode to steady-state in the cavity at 18 GHz and measuring the change in reflected power as the cavity is heated from high-power pulsed RF. Two experimental runs were completed. One run was executed at a calculated temperature rise of 120 K for 56 x 10{sup 6} pulses. The second run was executed at a calculated temperature rise of 82 K for 86 x 10{sup 6} pulses. Scanning electron microscope pictures show extensive damage occurring in the region of maximum temperature rise on the surface of the test pieces.

  18. Efficient Pulsed Quadrupole

    CERN Document Server

    Petzenhauser, I.; Spiller, P.; Tenholt, C.

    2016-01-01

    In order to raise the focusing gradient in case of bunched beam lines, a pulsed quadrupole was designed. The transfer channels between synchrotrons as well as the final focusing for the target line are possible applications. The quadrupole is running in a pulsed mode, which means an immense saving of energy by avoiding standby operation. Still the high gradients demand high currents. Hence a circuit had to be developed which is able to recover a significant amount of the pulsing energy for following shots. The basic design of the electrical circuit of the quadrupole is introduced. Furthermore more energy efficient circuits are presented and the limits of adaptability are considered.

  19. Pulse joining cartridges

    Energy Technology Data Exchange (ETDEWEB)

    Golovashchenko, Sergey Fedorovich; Bonnen, John Joseph Francis

    2016-08-23

    A pulsed joining tool includes a tool body that defines a cavity that receives an inner tubular member and an outer tubular member and a pulse joining cartridge. The tubular members are nested together with the cartridge being disposed around the outer tubular member. The cartridge includes a conductor, such as a wire or foil, that extends around the outer tubular member and is insulated to separate a supply segment from a return segment. A source of stored electrical energy is discharged through the conductor to join the tubular members with an electromagnetic force pulse.

  20. DogPulse

    DEFF Research Database (Denmark)

    Skovgaard, Christoffer; Thomsen, Josephine Raun; Verdezoto, Nervo;

    2015-01-01

    This paper presents DogPulse, an ambient awareness system to support the coordination of dog walking among family members at home. DogPulse augments a dog collar and leash set to activate an ambient shape-changing lamp and visualize the last time the dog was taken for a walk. The lamp gradually...... changes its form and pulsates its lights in order to keep the family members aware of the dog walking activity. We report the iterative prototyping of DogPulse, its implementation and its preliminary evaluation. Based on our initial findings, we present the limitations and lessons learned as well...

  1. 电磁脉冲对犬淋巴细胞损伤及其机制的实验研究%Effect and mechanism of electronic magnetic pulse on peripheral lymphocytes in dogs

    Institute of Scientific and Technical Information of China (English)

    崔玉芳; 杨红; 高亚兵; 崔雪梅; 熊呈琦; 高临路; 王德文

    2001-01-01

    Objective To study the effects of electronic magnetic pulse (EMP) on peripheral lymphocytes in dogs and to explore the mechanisms of the biological effects of EMP. Methods T, TH and Ts lymphocytes were estimated by acid phosphatase cytochemistry. Apoptotic lymphocytes and Bax and Bcl-2 proteins related to apoptosis were observed with in situ terminal labeling and immunocytochemistry. Results Peripheral T lymphocyte subpopulations decreased obviously after EMP irradiation with (2 - 12) × 104 V/m. Apoptotic percentages of lymphocytes increased with the elevation of EMP doses. Ten days after different intensity radiation, the Bax protein was found to be elevated in accord with the peak value of lymphocyte apoptosis. However, Bcl-2 protein decreased obviously. Conclusion A definite field intensity EMP could induce injury to lymphocytes. Apoptosis induced by EMP is one of the main causes of peripheral lymphocyte death and leads to immunosuppression of the body. These results suggest that people should pay more attention to the injury caused by EMP, especially to the immunological functions of the body.%目的研究电磁脉冲(EMP)对犬淋巴细胞的损伤效应,并探讨其作用机理。 方法用酸性磷酸酯酶细胞化学方法检测T、TH和Ts淋巴细胞,用原位末端标记和免疫细胞化学技术分析淋巴细胞凋亡和Bcl-2、Bax蛋白的改变。结果 (2-12)×104 V/m的场强能使外周血T细胞及其亚群出现明显降低;凋亡淋巴细胞随照射剂量的增加而明显升高;不同剂量照射后10天,淋巴细胞Bax蛋白的表达明显增强,与淋巴细胞凋亡呈现出比较好的相关性,而Bcl-2蛋白显著降低。 结论首次证实一定场强的EMP确实能损伤淋巴细胞,并呈现出较好的剂量效应关系。淋巴细胞凋亡是EMP引起淋巴细胞死亡和机体免疫功能降低的主要原因,Bax和Bcl-2在上述凋亡调控中起着重要作用。

  2. Retrospective survey of the efficacy of mandatory implementation of the Essential Medicine Policy in the primary healthcare setting in China: failure to promote the rational use of antibiotics in clinics.

    Science.gov (United States)

    Xiao, Yonghong; Wang, Jin; Shen, Ping; Zheng, Beiwen; Zheng, Yingdong; Li, Lanjuan

    2016-10-01

    The objective of this study was to understand the impact of implementation of the Essential Medicine Policy (EMP) on the rational use of antibiotics in primary medical institutions in China. A retrospective survey was conducted in 39 primary medical institutions to compare the efficacy of EMP in rational antibiotic use. All institutions completed the survey 1 year before and 1 year after implementation of the EMP. In particular, antibiotic use and its rationality were closely examined. The institutions mainly dealt with common diseases, especially non-infectious chronic diseases. Antibiotic usage was very inappropriate both before and after EMP implementation. Before and after EMP implementation, respectively, the median outpatient cost was US$6.34 and US$5.05, 52.50% (2005/3819) and 53.41% (1865/3492) of the outpatient prescriptions contained antibiotics, and 76.23% (1132/1485) and 78.83% (1106/1403) of inpatients were administered antibiotics. In addition, 98.38% (425/432) and 97.52% (512/525) of surgical inpatients were administered antibiotics, respectively, and 80.76% (638/790) and 75.19% (503/669) of patients with a cold were prescribed antibiotics, respectively. The most commonly used antibiotics were broad-spectrum and injectable agents, including cephalosporins, fluoroquinolones and penicillins. This profile showed little change following implementation of the EMP. In conclusion, inappropriate antibiotic use is a serious problem in primary medical institutions in China. Whilst enforcing the EMP reduced the cost of medical services, it had little effect on promoting the rational use of antibiotics.

  3. Bullying e Homofobia: Aproximações Teóricas e Empíricas

    OpenAIRE

    Souza,Jackeline Maria de; Silva,Joilson Pereira da; Faro, André

    2015-01-01

    Resumo:Este estudo objetivou verificar como os fenômenos bullying e homofobia se aproximam, comparando a homofobia entre os atores do bullying (autor, alvo, alvo/autor e testemunhas) e observando se o conteúdo homofóbico é utilizado no bullying verbal. Foi realizado um estudo descritivo e quantitativo como método survey. Participaram 808 jovens com idade média de 14,9 anos (DP = 1,98), oriundos de 9escolas estaduais de Aracaju-SE, que responderam a um questionário contendo questões sociodemog...

  4. Vertical Electromagnetic Pulse (VEMP) Testing

    Science.gov (United States)

    2009-09-11

    Device Measurement Accuracy Current Current Probes ±5% E-Field D-Dot Probe ±5% H-field B-Dot Probe ±5% Test Setup Digital Camera > 2 Megapixel...electromagnetic environment produced by a nuclear weapon consists of the ionization of the atmosphere and generation of an EMP. The gamma rays, neutrons , beta...Measurements . Measurements of each illumination will be made using an Electric Flux Density per unit time (D-dot) probes, so that the magnitude of

  5. Pulse measurement apparatus and method

    Science.gov (United States)

    Marciante, John R.; Donaldson, William R.; Roides, Richard G.

    2011-10-25

    An embodiment of the invention is directed to a pulse measuring system that measures a characteristic of an input pulse under test, particularly the pulse shape of a single-shot, nano-second duration, high shape-contrast optical or electrical pulse. An exemplary system includes a multi-stage, passive pulse replicator, wherein each successive stage introduces a fixed time delay to the input pulse under test, a repetitively-gated electronic sampling apparatus that acquires the pulse train including an entire waveform of each replica pulse, a processor that temporally aligns the replicated pulses, and an averager that temporally averages the replicated pulses to generate the pulse shape of the pulse under test. An embodiment of the invention is directed to a method for measuring an optical or an electrical pulse shape. The method includes the steps of passively replicating the pulse under test with a known time delay, temporally stacking the pulses, and temporally averaging the stacked pulses. An embodiment of the invention is directed to a method for increasing the dynamic range of a pulse measurement by a repetitively-gated electronic sampling device having a rated dynamic range capability, beyond the rated dynamic range of the sampling device; e.g., enhancing the dynamic range of an oscilloscope. The embodied technique can improve the SNR from about 300:1 to 1000:1. A dynamic range enhancement of four to seven bits may be achieved.

  6. Aspectos conceptuales y empíricos de la financiación de nuevas empresas en Colombia Conceptual and empirical aspects of the financing of new companies in Colombia

    Directory of Open Access Journals (Sweden)

    Bernardo Barona Zuluaga

    2010-06-01

    Full Text Available Este artículo presenta los resultados de una investigación empírica sobre la utilización de diferentes fuentes de financiación por parte de empresas nuevas en los primeros anos de vida. El principal soporte conceptual del estudio es el paradigma del ciclo de crecimiento financiero desarrollado por Berger y Udell (1998, el cual explica satisfactoriamente los hallazgos encontrados en el componente empírico del estudio aquí presentado, que se basa en una encuesta realizada a 130 empresarios de la Ciudad de Cali (Colombia. Los entrevistados reportaron de manera mayoritaria el uso de recursos propios y de familiares y amigos y la retención de utilidades en los primeros anos de vida de una empresa. Le sigue en importancia a estas fuentes, la financiación provista por establecimientos de crédito; llama la atención la importancia relativa del leasing. Las recomendaciones mas importantes incluyen: fortalecer las fuentes de capital semilla, darle mayor peso en los cursos de finanzas de nivel universitario al estudio de los problemas de las empresas nuevas y MIPYMES, adelantar una reforma financiera que facilite la emisión de acciones y mejorar la cantidad y calidad de información pública disponible sobre la financiación de las empresas objeto de este estudio.This article presents the results of an empirical research on the type of financial resources used by a sample of new enterprises in their early years of life. The main conceptual support of the study is the financial growth cycle paradigm developed by Berger and Udell (1998. This paradigm successfully explains the findings in the empirical component of the study presented here, which is based on a survey of 130 entrepreneurs in the city of Cali, Colombia. The survey results highlighted the importance of the use of financial resources provided by the owner and theirs family and friends, and of the retention of profits in their companies in the early years. Next in importance is the

  7. Pulse subtraction Doppler

    Science.gov (United States)

    Mahue, Veronique; Mari, Jean Martial; Eckersley, Robert J.; Caro, Colin G.; Tang, Meng-Xing

    2010-01-01

    Recent advances have demonstrated the feasibility of molecular imaging using targeted microbubbles and ultrasound. One technical challenge is to selectively detect attached bubbles from those freely flowing bubbles and surrounding tissue. Pulse Inversion Doppler is an imaging technique enabling the selective detection of both static and moving ultrasound contrast agents: linear scatterers generate a single band Doppler spectrum, while non-linear scatterers generate a double band spectrum, one being uniquely correlated with the presence of contrast agents and non-linear tissue signals. We demonstrate that similar spectrums, and thus the same discrimination, can be obtained through a Doppler implementation of Pulse Subtraction. This is achieved by reconstructing a virtual echo using the echo generated from a short pulse transmission. Moreover by subtracting from this virtual echo the one generated from a longer pulse transmission, it is possible to fully suppress the echo from linear scatterers, while for non-linear scatterers, a signal will remain, allowing classical agent detection. Simulations of a single moving microbubble and a moving linear scatterer subject to these pulses show that when the virtual echo and the long pulse echo are used to perform pulsed Doppler, the power Doppler spectrum allows separation of linear and non-linear moving scattering. Similar results are obtained on experimental data acquired on a flow containing either microbubble contrast agents or linear blood mimicking fluid. This new Doppler method constitutes an alternative to Pulse Inversion Doppler and preliminary results suggest that similar dual band spectrums could be obtained by the combination of any non-linear detection technique with Doppler demodulation.

  8. Pulsed spallation Neutron Sources

    Energy Technology Data Exchange (ETDEWEB)

    Carpenter, J.M. [Argonne National Lab., IL (United States)

    1994-12-31

    This paper reviews the early history of pulsed spallation neutron source development at Argonne and provides an overview of existing sources world wide. A number of proposals for machines more powerful than currently exist are under development, which are briefly described. The author reviews the status of the Intense Pulsed Neutron Source, its instrumentation, and its user program, and provides a few examples of applications in fundamental condensed matter physics, materials science and technology.

  9. Four pulse recoupling

    Science.gov (United States)

    Khaneja, Navin; Kumar, Ashutosh

    2016-11-01

    The paper describes a family of novel recoupling pulse sequences in magic angle spinning (MAS) solid state NMR, called four pulse recoupling. These pulse sequences can be employed for both homonuclear and heteronuclear recoupling experiments and are robust to dispersion in chemical shifts and rf-inhomogeneity. The homonuclear pulse sequence consists of a building block (π/2) 0 °(3π/2) ϕ°(π/2) 180 ° + ϕ°(3π/2) 180 ° where ϕ = π/n (ϕ° = 180°/n) , and n is number of blocks in a two rotor period. The heteronuclear recoupling pulse sequence consists of a building block (π/2) 0 °(3π/2) ϕ1 °(π/2) 180 ° +ϕ1 °(3π/2) 180 ° and (π/2) 0 °(3π/2) ϕ2 °(π/2) 180 ° +ϕ2 °(3π/2) 180 ° on channel I and S, where ϕ1 = 3π/2n, ϕ2 = π2/n and n is number of blocks in a two rotor period. The recoupling pulse sequences mix the y magnetization. We show that four pulse recoupling is more broadband compared to three pulse recoupling [1]. Experimental quantification of this method is shown for 13Cα-13CO, homonuclear recoupling in a sample of Glycine and 15N-13Cα, heteronuclear recoupling in Alanine. Application of this method is demonstrated on a sample of tripeptide N-formyl-[U-13C,15N]-Met-Leu-Phe-OH (MLF).

  10. High voltage pulse generator

    Science.gov (United States)

    Fasching, George E.

    1977-03-08

    An improved high-voltage pulse generator has been provided which is especially useful in ultrasonic testing of rock core samples. An N number of capacitors are charged in parallel to V volts and at the proper instance are coupled in series to produce a high-voltage pulse of N times V volts. Rapid switching of the capacitors from the paralleled charging configuration to the series discharging configuration is accomplished by using silicon-controlled rectifiers which are chain self-triggered following the initial triggering of a first one of the rectifiers connected between the first and second of the plurality of charging capacitors. A timing and triggering circuit is provided to properly synchronize triggering pulses to the first SCR at a time when the charging voltage is not being applied to the parallel-connected charging capacitors. Alternate circuits are provided for controlling the application of the charging voltage from a charging circuit to be applied to the parallel capacitors which provides a selection of at least two different intervals in which the charging voltage is turned "off" to allow the SCR's connecting the capacitors in series to turn "off" before recharging begins. The high-voltage pulse-generating circuit including the N capacitors and corresponding SCR's which connect the capacitors in series when triggered "on" further includes diodes and series-connected inductors between the parallel-connected charging capacitors which allow sufficiently fast charging of the capacitors for a high pulse repetition rate and yet allow considerable control of the decay time of the high-voltage pulses from the pulse-generating circuit.

  11. O paraíso do astrónomo: o Céu Empíreo segundo Cristoforo Borri (1583-1632

    Directory of Open Access Journals (Sweden)

    Luís Miguel Carolino

    2009-06-01

    Full Text Available Neste artigo, analisar-se-á a teoria do céu empíreo segundo o astrônomo Cristoforo Borri (1583-1632. Esta era uma das poucas teorias que, a partir de inícios do século XVII e salvo casos excepcionais, foi defendida quase exclusivamente por autores católicos e, em particular, por jesuítas. Na concepção cosmológica tradicional, o céu empíreo era um céu corpóreo que limitava o universo e no qual se encontravam Deus e os bem-aventurados. Não havia evidência física deste céu e, por isso, as razões para defender a existência do céu empíreo eram basicamente de natureza teológica e filosófica. Assim, se compreende que a maioria dos autores que fundamentam a existência e discutem as características deste céu sejam teólogos ou filósofos. Contudo, na primeira metade do século XVII, um conjunto de astrônomos jesuítas dedicou-se, também, à análise do céu empíreo, propondo uma visão integrada do cosmos onde explicações provenientes da teologia, filosofia e matemática se complementavam. Entre estes astrônomos, destaca-se o italiano Cristoforo Borri, autor de Collecta astronomica ex doctrina, obra publicada em Lisboa, em 1631. Nesta obra, que teve grande impacto no mundo cultural de influência portuguesa, Borri defendeu uma divisão tripartida dos céus, segundo a qual o universo se organizaria em céu aéreo, céu etéreo e céu empíreo. Qual era a natureza deste último céu? Era o céu empíreo um corpo sólido ou fluido? Qual era a sua forma? Estas são algumas das questões em análise no presente artigo.

  12. Sequence variation of PfEMP1-DBLα in association with rosette formation in Plasmodium falciparum isolates causing severe and uncomplicated malaria

    Directory of Open Access Journals (Sweden)

    Craig Alister

    2009-08-01

    Full Text Available Abstract Background Rosetting and cytoadherence of Plasmodium falciparum-infected red blood cells have been associated with severity of malaria. ICAM-1 and CD36 are the main host cell receptors, while PfEMP1-DBLα is a major parasite ligand, which can contribute to rosette formation. This study is aimed at demonstrating whether the highly polymorphic PfEMP1-DBLα sequences occurring among Thai isolates causing severe and uncomplicated malaria are associated with their ability to form rosettes and reflected the clinical outcome of the patients. Methods Two hundred and ninety five PfEMP1-DBLα sequences from Thai clinical isolates causing severe and uncomplicated malaria were evaluated by sequencing and direct comparison using the specific text string analysis functions in Microsoft Excel and Perl. The relationships between the PfEMP1-DBLα sequences were also analysed by network analysis. The binding abilities of parasitized red blood cells (PRBCs to CD36, wild type ICAM-1, ICAM-1Kilifi and ICAM-1S22/A under static condition were included. Results Two hundred and eighty one non-identical amino acid sequences were identified (p = 0.027. By using a simple non-phylogenetic approach to visualize the sharing of polymorphic blocks (position specific polymorphic block, PSPB and cys/PoLV among DBLα sequences, the sequence group 1 was split from the other five sequence groups. The isolates belonging to sequence group 5 gave the highest mean rosetting rate (21.31%. However, within sequence group 2 and group 6, the isolates causing severe malaria had significantly higher rosetting rate than those causing uncomplicated malaria (p = 0.014, p = 0.007, respectively. Conclusion This is the first report of PfEMP1-DBLα analysis in clinical Thai isolates using semi-conserved features (cys/PoLV and PSPBs. The cys/PoLV group 5 gave the highest rosetting rate. PfEMP1-DBLα domains in Thai isolates are highly diverse, however, clinical isolates from severe and

  13. Orientación empática en estudiantes de medicina de las Universidades Libre y San Martín, Barranquilla, Colombia

    Directory of Open Access Journals (Sweden)

    Jorge Luis Bilbao

    2015-10-01

    Full Text Available Antecedentes. La empatía es un importante atributo que los estudiantes de medicina deben tener y ha sido poco estudiado en América Latina. Objetivo. Determinar el nivel de orientación empática de los estudiantes de medicina de las universidades Libre, seccional Barranquilla, y San Martín, sede Puerto Colombia, Barranquilla. Materiales y métodos. La orientación empática de los estudiantes se midió mediante la aplicación de la Escala de Empatía Médica de Jefferson en español, diseñada para estudiantes -versión S-, validada en otros países de Latinoamérica y adaptada culturalmente a Colombia. La comparación de los datos se realizó mediante análisis de varianza bifactorial -Modelo III-. Resultados. El nivel de orientación empática de los estudiantes tiene valores bajos, ubicados por encima del valor central del rango de la escala, 20 a140. Las diferencias entre las puntuaciones, según cursos y género, no fueron estadísticamente significativas al comparar los promedios de las sumatorias del puntaje de los estudiantes; sin embargo, se observó, un comportamiento diferente según el género entre las universidades: el femenino tuvo valores de orientación empática mejores que el masculino en la Universidad San Martín, mientras que en la Universidad Libre sucedió, relativamente, lo contrario. La comparación de las respuestas permitió observar que existen diferencias entre ellas. Conclusiones. Los resultados de este estudio no explican la contradicción encontrada en relación a las diferencias de género y cursos entre universidades; sin embargo, estos resultados son consistentes con otros trabajos, especialmente realizados en Latinoamérica, que muestran variabilidad de la respuesta empática en estudiantes de medicina. Las diferencias entre las universidades no pueden atribuirse a causas psicológicas solamente, sino a la presencia de otros factores que también influyen en la respuesta empática.

  14. Organização de Reparo na Conversa Cotidiana: um Estudo Empírico

    Directory of Open Access Journals (Sweden)

    Caroline Caputo Pires

    2017-02-01

    Full Text Available O presente trabalho visa analisar ocorrências de trajetórias de reparo com dados em fala-em-interação em uma filmagem com quatro brasileiros intercambistas na Alemanha, no qual apresentam suas experiências no período de um ano em contato com outra língua e cultural. Assim, para descrever o fenômeno de reparo (SIDNELL, 2010, GARCEZ, 2008, LODER, 2005 é importante destacar que os participantes em interação e demonstrável pela articulação de análises comunicacionais, o fenômeno do reparo é importante para a interpretação em relação à correção na fala-em-interação, na medida em que o reparo se refere às práticas que participantes usam para contornar problemas ou obstáculos na fala, audição ou compreensão da fala. Enfatiza-se, nesse trabalho, que os estudos sobre reparo na fala-em-interação se deram no campo dos estudos da Análise da Conversa, entre estudiosos que se interessam nas ações cotidianas na vida das pessoas. Dessa forma, a base empírica desse trabalho focalizará os conceitos da Análise da Conversa, fenômenos de reparo em uma filmagem de uma interação de brasileiros em intercambio no ano de 2014. Os dados empíricos fazem parte do projeto da UFMG que investiga perspectivas comunicativas e as atitudes extracomunicativas que indivíduos realizam e desenvolvem no decorrer de um encontro intercultural de duração maior.

  15. Evidencia Empírica sobre la Paridad del Poder Adquisitivo en México Evidencia Empírica sobre la Paridad del Poder Adquisitivo en México

    Directory of Open Access Journals (Sweden)

    Lorena Medina

    2012-02-01

    Full Text Available This article describes the application of methods recently developed for testing stationarity in the Mexico/US real exchange rate, while allowing for an unknown number of structural breaks in the long-run level of the series. In our empirical implementation, inference relies on bootstraped critical values. As a result, we present unambiguous empirical evidence on the stationarity of the real exchange rate, thus favoring long-run purchasing power parity. En este artículo se describe la aplicación de métodos recientes para probar la estacionariedad del tipo de cambio real peso/dólar, tomando en cuenta la presencia de un número desconocido de cambios estructurales en el nivel de largo plazo de la serie. En nuestra implementación empírica, la inferencia se basa en valores críticos fundamentados en técnicas de remuestreo. Se presenta evidencia contundente sobre la estacionariedad del tipo de cambio real, apoyando así la hipótesis de la paridad del poder adquisitivo.

  16. EMPulse, a new 3-D simulation code for electromagnetic pulse studies

    Science.gov (United States)

    Cohen, Bruce; Eng, Chester; Farmer, William; Friedman, Alex; Grote, David; Kruger, Hans; Larson, David

    2016-10-01

    EMPulse is a comprehensive and modern 3-D simulation code for electro-magnetic pulse (EMP) formation and propagation studies, being developed at LLNL as part of a suite of codes to study E1 EMP originating from prompt gamma rays. EMPulse builds upon the open-source Warp particle-in-cell code framework developed by members of this team and collaborators at other institutions. The goal of this endeavor is a new tool enabling the detailed and self-consistent study of multi-dimensional effects in geometries that have typically been treated only approximately. Here we present an overview of the project, the models and methods that have been developed and incorporated into EMPulse, tests of these models, comparisons to simulations undertaken in CHAP-lite (derived from the legacy code CHAP due to C. Longmire and co-workers), and some approaches to increased computational efficiency being studied within our project. This work was performed under the auspices of the U.S. DOE by Lawrence Livermore National Security, LLC, Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  17. Discharge pulse phenomenology

    Science.gov (United States)

    Frederickson, A. R.

    1985-01-01

    A model was developed which places radiation induced discharge pulse results into a unified conceptual framework. Only two phenomena are required to interpret all space and laboratory results: (1) radiation produces large electrostatic fields inside insulators via the trapping of a net space charge density; and (2) the electrostatic fields initiate discharge streamer plasmas similar to those investigated in high voltage electrical insulation materials; these streamer plasmas generate the pulsing phenomena. The apparent variability and diversity of results seen is an inherent feature of the plasma streamer mechanism acting in the electric fields which is created by irradiation of the dielectrics. The implications of the model are extensive and lead to constraints over what can be done about spacecraft pulsing.

  18. Pulsed ELDOR detected NMR

    Science.gov (United States)

    Schosseler, P.; Wacker, Th.; Schweiger, A.

    1994-07-01

    A pulsed EPR method for the determination of small hyperfine interactions in disordered systems is described. A selective preparation pulse of frequency ω mw(1) excites allowed and forbidden transitions, thereby burning spectral holes into the EPR line. The positions of the holes caused by the excitation of forbidden transitions correspond to the nuclear transition frequencies of the spin system. A selective detection pulse of frequency ω mw(2) creates an FID with integrated intensity proportional to the magnetization at frequency ω mw(2). The entire hole pattern is obtained by recording the integrated intensity of the FID while varying the frequency difference Δω mw=ω mw(1)-ω mw(2) step by step.

  19. Herophilus on pulse

    Directory of Open Access Journals (Sweden)

    Afonasin, Eugene

    2015-01-01

    Full Text Available The first detailed study of the pulse (sphygmology is associated in antiquity with Herophilus (the end of the 4th century BCE, an Alexandrian physician, renowned for his anatomical discoveries. The scholars also attribute to him a discovery of a portable and adjustable water-clock, used for measuring ‘natural’ and ‘unnatural’ pulse and, accordingly, temperature of the patient. In the article we translate the principal ancient evidences and comment upon them. We study both the practical aspects of ancient sphygmology and the theoretical speculations associated with it. Ancient theory of proportion and musical harmony allowed to build a classification of the pulses, but the medical experience did not fit well in the Procrustean bed of this rather simple theory.

  20. Pulsed Artificial Electrojet Generation

    Science.gov (United States)

    Papadopoulos, K.

    2008-12-01

    Traditional techniques for generating low frequency signals in the ULF/ELF range (.1-100 Hz) and rely on ground based Horizontal Electric Dipole (HED) antennas. It is, furthermore, well known that a Vertical Electric Dipole (VED) is by more than 50 dB more efficient than a HED with the same dipole current moment. However, the prohibitively long length of VED antennas in the ELF/ULF range coupled with voltage limitations due to corona discharge in the atmosphere make them totally impracticable. In this paper we discuss a novel concept, inspired by the physics of the equatorial electrojet, that allows for the conversion of a ground based HED to a VED in the E-region of the equatorial ionosphere with current moment comparable to the driving HED. The paper focuses in locations near the dip-equator, where the earth's magnetic is in predominantly in the horizontal direction. The horizontal electric field associated with a pulsed HED drives a large Hall current in the ionospheric E-region, resulting in a vertical current. It is shown that the pulsed vertical current in the altitude range 80-130 km, driven by a horizontal electric field of, approximately, .1 mV/m at 100 km altitude, is of the order of kA. This results in a pulsed VED larger than 106 A-m. Such a pulsed VED will drive ELF/ULF pulses with amplitude in excess of .1 nT at a lateral range larger than few hundred kilometers. This is by three orders of magnitude larger than the one expected by a HED with comparable current moment. The paper will conclude with the description of a sneak-through technique that allows for creating pulsed electric fields in the ionosphere much larger than expected from steady state oscillatory HED antennas.

  1. Two pulse recoupling

    Science.gov (United States)

    Khaneja, Navin; Kumar, Ashutosh

    2017-08-01

    The paper describes a family of novel recoupling pulse sequences in magic angle spinning (MAS) solid state NMR, called two pulse recoupling. These pulse sequences can be employed for both homonuclear and heteronuclear recoupling experiments and are robust to dispersion in chemical shifts and rf-inhomogeneity. The homonuclear pulse sequence consists of a building block (π)ϕ(π) - ϕ where ϕ =π/4n, and n is number of blocks in a rotor period. The recoupling block is made robust to rf-inhomogeneity by extending it to (π)ϕ(π) - ϕ(π) π + ϕ(π) π - ϕ . The heteronuclear recoupling pulse sequence consists of a building block (π)ϕ1(π)-ϕ1 and (π)ϕ2(π)-ϕ2 on channel I and S, where ϕ1 = 3π/8n, ϕ2 = π/8n and n is number of blocks in a rotor period. The recoupling block is made robust to rf-inhomogeneity by extending it to (π)ϕ1(π)-ϕ1(π) π +ϕ1(π) π -ϕ1 and (π)ϕ2(π)-ϕ2(π) π +ϕ2(π) π -ϕ2 on two channels respectively. The recoupling pulse sequences mix the z magnetization. Experimental quantification of this method is shown for 13Cα-13CO homonuclear recoupling in a sample of Glycine and 15N-13Cα heteronuclear recoupling in Alanine. Application of this method is demonstrated on a sample of tripeptide N-formyl-[U-13C,15N]-Met-Leu-Phe-OH (MLF). Compared to R-sequences (Levitt, 2002), these sequences are more robust to rf-inhomogeneity and give better sensitivity, as shown in Fig. 3.

  2. Pulse Doppler radar

    CERN Document Server

    Alabaster, Clive

    2012-01-01

    This book is a practitioner's guide to all aspects of pulse Doppler radar. It concentrates on airborne military radar systems since they are the most used, most complex, and most interesting of the pulse Doppler radars; however, ground-based and non-military systems are also included. It covers the fundamental science, signal processing, hardware issues, systems design and case studies of typical systems. It will be a useful resource for engineers of all types (hardware, software and systems), academics, post-graduate students, scientists in radar and radar electronic warfare sectors and milit

  3. Pulsed Electron Holography

    CERN Document Server

    Germann, Matthias; Escher, Conrad; Fink, Hans-Werner

    2013-01-01

    A technique of pulsed low-energy electron holography is introduced that allows for recording highly resolved holograms within reduced exposure times. Therefore, stacks of holograms are accumulated in a pulsed mode with individual acquisition times as short as 50 {\\mu}s. Subsequently, these holograms are aligned and finally superimposed. The resulting holographic record reveals previously latent high-order interference fringes and thereby pushing interference resolution into the sub-nanometer regime. In view of the non-damaging character of low-energy electrons, the method is of particular interest for structural analysis of fragile biomolecules.

  4. Modelo empírico para previsión de la temperatura superfi cial del mar peruano

    Directory of Open Access Journals (Sweden)

    Benjamin Matellini

    2013-04-01

    Full Text Available En el presente trabajo se estudia un modelo empírico basado en el volumen de agua cálida en el Pacífi co ecuatorial que se aplica para hacer previsiones de temperatura superfi cial del mar frente a Perú, lo cual sirve como una herramienta de alerta temprana de los efectos de El Niño. La relación del volumen de agua cálida con la profundidad de la isoterma de 20 °C es mayor en el Pacífi co central en la latitud cero. Los cambios de este volumen afectan después varios meses la temperatura superfi cial del mar frente a Perú, particularmente cuando este volumen presenta anomalías positivas. El modelo logra estimar el momento en que se inicia el aumento de temperatura superfi cial del mar asociado a los efectos de El Niño en la Región Niño 1 costera, el momento de ocurrencia del pico de los eventos, y las tendencias a mediano plazo.

  5. Aprendizaje Cooperativo: Bases teóricas y hallazgos empíricos que explican su eficacia

    Directory of Open Access Journals (Sweden)

    Edurne Goikoetxea

    2002-01-01

    Full Text Available El aprendizaje cooperativo (AC es una de las formas de organizar la enseñanza con mayor respaldo teórico y empírico, y cada vez más empleada. Este trabajo revisa la teoría del contacto de Allport (1954/1962 para explicar por qué los métodos de AC tienen efectos positivos en las relaciones intergrupales e interétnicas. El modelo de Slavin (1984 se revisa para juzgar los elementos de una instrucción eficaz que logran ser satisfechos por el AC, dando lugar a efectos positivos en el rendimiento académico. Se describen, además, los nueve métodos de AC más investigados y se resumen los principales hallazgos sobre sus efectos, así como los mecanismos que explican dichos efectos, según los estudios de revisión y de meta-análisis

  6. Persistencia y capacidad predictiva de márgenes y rotaciones. un análisis empírico

    Directory of Open Access Journals (Sweden)

    Juan Monterrey

    2011-01-01

    Full Text Available En el presente trabajo abordamos el estudio empírico de la persistencia y capacidad predictiva de los componentes margen y rotación de la rentabilidad. A partir de una amplia muestra de compañías españolas, hemos documentado cómo la persistencia de la rotación es superior a la del margen, y cómo los componentes anormales de margen y rotación son menos persistentes que sus componentes sectoriales. Con relación a la capacidad predictiva, nuestros hallazgos confirman que el poder de predicción del margen es más elevado que el de la rotación, aunque su persistencia sea menor. Al separar los componentes sectorial y anormal de margen y rotación hemos comprobado cómo los componentes anormales muestran una capacidad predictiva superior a los componentes sectoriales. Los análisis complementarios muestran el distinto poder predictivo según el signo positivo o negativo de márgenes y rotaciones anormales, y según el signo del resultado, así como la robustez de nuestros hallazgos.

  7. El carácter empírico y lógico de la contabilidad

    Directory of Open Access Journals (Sweden)

    Eduardo R. Scarano

    2009-12-01

    Full Text Available El objetivo de este artículo es argumentar acerca del carácter esencialmente empírico y científico de la contabilidad. Este punto de vista implica rechazar el carácter predominantemente normativo que posee la contabilidad, por lo menos, en Latinoamérica. Se considera que el normativismo de cualquier tipo es meramente secundario.La contabilidad es una disciplina científica, pero al carecer de leyes estrictas no constituye una ciencia básica, es una tecnología social.Se mostrará que tiene una estructura axiomática específica que se puede exponer con la lógica estándar, lo mismo que la matemática contable que supone la partida doble.The aim of this article is to argue about the essentially empirical and scientific character of the accounting. This point of view implies rejecting the predominantly normative character that possesses the accounting, at least, in Latin America. It thinks that the normativism of any type is merely secondary.The accounting is a scientific discipline, but it lacks strict laws, therefore, it does not constitute a basic science, is a social technology.It will appear that it has an axiomatic specific structure that can be exposed by the standard logic the same as the accounting mathematics that supposes the double entry.

  8. Resiliencia en Enfermería: definición, evidencia empírica e intervenciones

    Directory of Open Access Journals (Sweden)

    Óscar Arrogante

    2015-12-01

    Full Text Available La resiliencia (adaptación positiva a la adversidad se encuentra dentro de las competencias enfermeras al relacionarse con tres diagnósticos de la taxonomía NANDA y, además, la investigación enfermera señala que es una característica propia de la Enfermería. Sin embargo, la resiliencia es un concepto novedoso para la mayoría de las enfermeras. El artículo tiene como objetivos definir el concepto de resiliencia, exponer la evidencia empírica encontrada en la investigación enfermera y describir los principales programas e intervenciones para su desarrollo. La resiliencia tiene importantes implicaciones clínicas tanto para el cuidado de pacientes, como para el propio autocuidado de la Enfermería. La resiliencia se puede considerar como una característica esencial e inherente a la Enfermería debido a la exposición continua al sufrimiento humano y a unas condiciones laborales estresantes. Por lo tanto, su entrenamiento debería promoverse desde las universidades hasta los centros sanitarios para mejorar la práctica clínica enfermera.

  9. Paternidade no Brasil: revisão sistemática de artigos empíricos

    Directory of Open Access Journals (Sweden)

    Mauro Luís Vieira

    2014-01-01

    Full Text Available El objetivo del estudio fue caracterizar la producción de artículos empíricos rela - cionados con el tema de la paternidad y su contribución al desarrollo del niño y de la familia, publicados entre 2000 y 2012 en revistas brasileñas indexadas en bases de datos IndexPsi, SciELO y PePSIC. Los descriptores usados fueron: “padre”, “paternidad” y “paternal”. Un centenar de artículos fueron analizados en su totalidad. En el 70% de ellos, los autores utilizaron el análisis cualitativo de los datos. Se observó la preferencia por el método de recolección de datos (60% y por la entrevista como técnica de recogida (47%. Entre los temas investigados se destacan: embarazo, parto y puerperio (25%, el ejercicio de la paternidad (22%, el desarrollo del niño (15%, la adolescencia (14% y concep - tos sobre el comportamiento paternal (13%. Estudios futuros deben investigar al padre en diferentes contextos y la división de papeles en la familia, la inte - gración de los enfoques cuantitativos y cualitativos y los estudios longitudinales.

  10. Responsabilidad Social Universitaria: estudio empírico sobre la fiabilidad de un conjunto de indicadores de Gobierno Corporativo

    Directory of Open Access Journals (Sweden)

    Montserrat Núñez Chicharro

    2015-10-01

    Full Text Available La Responsabilidad Social de la Universidad (RSU puede ser definida observando los impactos que provoca en el desarrollo de sus actividades. Partiendo de los grupos de impactos, podemos considerar un modelo de medición, identificando los aspectos de la RSU, con cuatro dimensiones: 1 organizacional, 2 educativa, 3 investigadora y 4 epistemológica y social. El objetivo del presente trabajo consiste en verificar la validez de un conjunto de indicadores propuestos de RSU, bajo el prisma de la dimensión organizacional. Los indicadores de medición de los impactos a nivel organizacional se definen partiendo de la clasificación por dimensiones propuesta por el Global Reporting Initiative, incorporando aquellos considerados específicos de la actividad universitaria. De las cuatro categorías identificadas en esta dimensión, analizaremos la del Gobierno Corporativo, ya que los indicadores del impacto económico, social y medioambiental están ampliamente contrastados por el mismo. La metodología utilizada es de naturaleza empírica y está basada en la interacción directa con un conjunto de expertos. Un requisito que la información contable externa debe cumplir es el de fiabilidad. En el estudio, se plantea inferir la validez de los indicadores propuestos, en relación con el citado requisito, mediante valoraciones particulares relativas a la Imparcialidad, Objetividad, Verificabilidad y Representación fiel.

  11. Determinantes de la equidad en el financiamiento de los medicamentos en Argentina: un estudio empírico

    Directory of Open Access Journals (Sweden)

    Mariana Dondo

    2016-01-01

    Full Text Available Resumen Los medicamentos constituyen un alto porcentaje del gasto en salud de los hogares, por eso, tener un sistema progresivo de financiamiento de medicamentos es fundamental para lograr un sistema de salud equitativo. Se ha propuesto que los determinantes de la equidad en el financiamiento son socioeconómicos, demográficos y asociados a la intervención pública, sin embargo, se ha avanzado poco en su evaluación empírica y en la cuantificación de su importancia relativa. En este trabajo estimamos regresiones por cuantiles a nivel provincial en Argentina y encontramos que la población mayor a 65 años, el desempleo, la existencia de laboratorios públicos de producción de medicamentos, las transferencias de tratamientos y la orientación del sistema de salud a la atención primaria, son importantes predictores de la progresividad en el esquema de pagos. Ingresos bajos, instituciones débiles, infraestructura y provisión de servicios insuficientes redundan en respuestas sociales más regresivas a las necesidades sanitarias, empeorando las condiciones de vida y limitando las oportunidades de desarrollo.

  12. Sobre la disociación entre marco teórico y datos empíricos

    Directory of Open Access Journals (Sweden)

    Fernando Leal Carretero

    2009-01-01

    Full Text Available La observación y la experiencia muestran que tanto los proyectos de investigación en ciencias sociales como las tesis de grado o posgrado constan, con alarmante frecuencia, de dos partes claramente diferenciables: por un lado se presenta una serie de conceptos (más o menos bien definidos y una serie de referencias o incluso citas textuales a autores más o menos compatibles entre sí; por otro lado se presenta una serie de datos empíricos (cifras absolutas y relativas, correlaciones, acontecimientos, decretos, políticas, discursos más o menos heterogénea y más o menos fiable, la cual se discute, analiza o interpreta, bien independientemente de los conceptos y referencias de la primera parte o bien estableciendo apenas relaciones tenues con unos y otras. Esto puede verse como una anomalía que exige corrección o como el estado normal de las ciencias sociales en su situación actual. El artículo discute cuál de estas dos visiones se aproxima más a la realidad.

  13. La demanda de trabajo: teoría y evidencia empírica para el caso colombiano

    Directory of Open Access Journals (Sweden)

    Jairo Guillermo Isaza Castro

    2004-07-01

    Full Text Available Este documento presenta algunos de los aspectos teóricos más importantes para el análisis de la demanda de trabajo, así como la evidencia empírica disponible para el caso colombiano. En cuanto a los aspectos teóricos, la exposición se centra en la discusión microeonómica concerniente a las propiedades de la demanda de trabajo del empresario maximizador debeneficios que enfrenta un proceso productivo con dos factores: capital y trabajo. Luego se discuten las implicaciones de los procesos de liberalización y reformas estructurales en la demanda de trabajo. La revisión de literatura efectuada para el caso colombiano muestra cómo, en general, los estimativos de elasticidades de la demanda por trabajadores frente al producto y el salario real difieren sustancialmente debido a la diversidad de especificaciones econométricas, la temporalidad de los datos y las fuentes de los mismos.

  14. EMP chemical ages of monazites from Central Zone of the eastern Kunlun Orogen: Records of multi-tectonometamorphic events

    Institute of Scientific and Technical Information of China (English)

    CHEN NengSong; SUN Min; WANG QingYan; ZHAO GuoChun; CHEN Qiang; SHU GuiMing

    2007-01-01

    Two generations of monazite were identified in one mica schist sample from the central zone of the eastern Kunlun Orogen at the northern margin of the Qinghai-Tibet Plateau.The first generation was found in the cores of garnet porphyroblasts with relatively high Y2O3 contents (averaging 1.012±0.088 wt%).The second generation occurs either as inclusions in the rims of garnet porphyroblasts, matrix kyanite, plagioclase and quartz, or as separate crystals associated with matrix biotite and muscovite mostly having a relatively low Y2O3 content (averaging 0.479±0.100 wt%).Electron microprobe (EMP) Th-U-Pbtotal chemical dating for two grains of the first generation monazite yields average ages of 455 ± 18 Ma and 420 ± 20 Ma, respectively; six grains of the second generation gave an average age of 246.1 ± 3.8 Ma.These ages suggest that the core and rim of the garnet porphyroblasts and their associated assemblages record two events of significant tectonometamorphism.The formation of the Ordovician monazite is related to the tectonometamorphic event responsible for continuous amalgamation of the Gondwanaland in the Late Pan-African period or for consumption of the Proto-Tethys, whereas the development of the Triassic monazite is related to the tectonometamorphic event for consumption of the Paleo-Tethys.

  15. La PYME innovadora mexicana ante la crisis económica. Un estudio empírico

    Directory of Open Access Journals (Sweden)

    Edwin Estrella Pacheco

    2011-09-01

    Full Text Available Este trabajo estudia el crecimiento y el empleo de las empresas industriales manufactureras que son innovadoras del estado de Yucatán, en México, durante 2007-2009, periodo de la crisis financiera global. El incremento del desempleo es consecuencia del cierre de empresas, para recortar gastos. Se estudia el impacto de dicha crisis comparando el efecto en aquellas empresas que son innovadoras, con aquellas que no lo son. Se realiza un estudio empírico a 138 PYME, usando una entrevista dirigida a los gerentes, recolectando la información con un cuestionario, y analizándolo con técnicas multivariantes. Los resultados muestran que las PYME son en mayor medida poco innovadoras, que ambos tipos de empresas (innovadoras y no innovadoras en general conservaron el empleo, aunque las innovadoras mostraron mayor aumento en número de empleados que aquellas que son poco innovadoras. También se encontró que aquellas que son innovadoras tuvieron un mayor crecimiento que aquellas que son poco innovadoras. Referente al empleo, se encontró que aquellas que son innovadoras contrataron mayor número de trabajadores durante la crisis comparado con aquellas que son poco innovadoras. Se observó que las empresas innovadoras son en menor medida familiares, sus directivos cuentan con mayor formación universitaria, usan una estrategia agresiva (Exploradora-Analizadora y poseen mejor tecnología (Fuerte-Buena, contrastando con aquellas que son poco innovadoras.

  16. Modelo semi-empírico de protuberancia solar a partir del diagnóstico de densidades

    Science.gov (United States)

    Cirigliano, D.; Vial, J. C.; Rovira, M.

    A partir de la observación del espectro del quintuplete de C III alrededor de 1175 Å, se ha realizado el diagnóstico de la densidad y presión electrónica, basado en el cálculo del cociente de las intensidades observadas. Una vez establecida la densidad electrónica, y con el cálculo de las velocidades Doppler, hemos investigado el flujo de masa en la protuberancia en función de la temperatura. Estableciendo como hipótesis la conservación del número de partículas que ingresan y salen del cuerpo de la protuberancia, se investiga la variación del área de un tubo de flujo semi-empírico en función de la temperatura. A partir de dicho diagnóstico, se examina el comportamiento del radio del tubo magnético en función de la temperatura, los que dan cuenta de la abertura de las líneas de campo magnético que confinan el plasma y de la divergencia del campo magnético en diferentes alturas de la atmósfera solar.

  17. Overproduction, purification and crystallization of a chondroitin sulfate A-binding DBL domain from a Plasmodium falciparum var2csa-encoded PfEMP1 protein

    Energy Technology Data Exchange (ETDEWEB)

    Higgins, Matthew K., E-mail: mkh20@cam.ac.uk [Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA (United Kingdom)

    2008-03-01

    A chondroitin sulfate A-binding DBL important in placental malaria has been overproduced, purified and crystallized. Diffraction data were collected to 1.9 Å resolution. The PfEMP1 proteins of the malaria parasite Plasmodium falciparum are inserted into the membrane of infected red blood cells, where they mediate adhesion to a variety of human receptors. The DBL domains of the var2csa-encoded PfEMP1 protein play a critical role in malaria of pregnancy, tethering infected cells to the surface of the placenta through interactions with the glycosaminoglycan carbohydrate chondroitin sulfate A (CSA). A CSA-binding DBL domain has been overproduced in a bacterial expression system, purified and crystallized. Native data sets extending to 1.9 Å resolution have been collected and phasing is under way.

  18. Los conceptos innatos en la obra de Chomsky: definición y propuesta de un método empírico para su estudio

    Directory of Open Access Journals (Sweden)

    Oliver Müller

    2013-06-01

    Full Text Available Este artículo versa sobre los conceptos innatos: su definición, de acuerdo a la obra lingüística de Noam Chomsky, y el esbozo de un método que permita su estudio. A manera de introducción se refieren algunas concepciones académicas sobre la adquisición conceptual y se comenta la falta de un método de estudio empírico de los conceptos nativos. Enseguida, se presenta la definición que a lo largo del tiempo ha defendido Chomsky sobre dichos conceptos. Finalmente, se instauran de manera teórica las condiciones de un procedimiento empírico para el estudio de los conceptos innatos, titulado análisis semántico de corpus.

  19. Economía de la Familia: Una Aplicación Empírica del Modelo Unitario para Colombia

    Directory of Open Access Journals (Sweden)

    Serrano Edgar David

    2003-08-01

    Full Text Available

    Serrano, Edgar David. "Economía de una Familia: Una Aplicación Empírica del Modelo Unitario para Colombia". Cuadernos de Economía, V. XXII, n. 38, Bogotá, 2003, páginas 151-177.

    El articulo expone los elementos sustanciales del modelo unitario en la perspectiva de Samuelson (Concenso (1956, con el proposito de discutir la fortaleza teórica de los supuestos de preferencias de grupo y el fondo de ingresos común. El desarrollo del modelo empírico aplicado en esta vía de corroborar si estas presuposiciones teóricas se sostienen en el caso colombiano para la información disponible, analizando además las implicaciones que en política social tiene el implementar el modelo unitario.

  20. Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolates

    DEFF Research Database (Denmark)

    Sander, Adam F; Salanti, Ali; Lavstsen, Thomas;

    2009-01-01

    BACKGROUND: The var2csa gene encodes a Plasmodium falciparum adhesion receptor which binds chondroitin sulfate A (CSA). This var gene is more conserved than other PfEMP1/var genes and is found in all P. falciparum isolates. In isolates 3D7, FCR3/It4 and HB3, var2csa is transcribed from a sub...... distinct phylogenetic groups possessing one or the other variant of a large (approximately 26 amino acid) dimorphic motif, but whether either motif variant is linked to a specific locus is not known. CONCLUSIONS/SIGNIFICANCE: Two or more related but distinct var2csa-type PfEMP1/var genes exist in many P...

  1. La dialéctica temporal de la observación empírica en las ciencias de la sociedad

    Directory of Open Access Journals (Sweden)

    JAVIER CALLEJO

    2012-01-01

    Full Text Available A partir de un diálogo entre las obras de autores tan distantes como Michel de Certeau y Niklas Luhmann, se realiza un trabajo de proyección de los conceptos de estrategia y táctica en el análisis de las distintas dimensiones temporales presentes en la observación empírica de las ciencias sociales. Aparecen dos temporalidades prácticamente opuestas, la de la duración de las estrategias y la del instante de las tácticas. La temporalidad propia del sistema social de la ciencia y la temporalidad del encuentro entre este sistema social y los sistemas sociales observados. Dos temporalidades que parecen negarse recíprocamente y que, sin embargo, en su relación, construyen la observación empírica.

  2. La tasa de crecimiento garantizada de Harrod como ley del crecimiento económico. Una comprobación empírica

    Directory of Open Access Journals (Sweden)

    Bernal Bellón José Reyes Reyes

    2008-12-01

    Full Text Available En teoría del crecimiento hubo desarrollos importantes en la década de los 50 a partir del modelo de crecimiento poskeynesiano de Harrod (1939, los cuales buscaban solucionar teóricamente el problema de inestabilidad que presentaba este modelo. No obstante, no se ha realizado una comprobación empírica literal del modelo. En el presente trabajo se modifica el modelo de Harrod incluyendo el cambio técnico y se realiza una comprobación
    empírica a través de diferentes metodologías. Se concluye que la tasa de crecimiento garantizada de Harrod tiende a ser una ley en teoría del crecimiento económico.

  3. Implicaciones teóricas y empíricas de la nueva definición de desempleo en Colombia.

    Directory of Open Access Journals (Sweden)

    Juan Carlos Guataqui

    2010-05-01

    Full Text Available En junio de 2000 Colombia adoptó una nueva definición de desempleo siguiendo los estándares de la OIT. Este cambio implicó una reducción de la tasa de desempleo del orden de dos puntos porcentuales. En este documento contrastamos el caso Colombiano con las experiencias de otros países en términos de la transformación metodológica y sus implicaciones empíricas. Posteriormente, evaluamos el soporte empírico del cambio de metodología. Nuestros resultados sugieren implicaciones específicas sobre el desempleo estructural y su relación con el perfil educativo de los desempleados; por lo tanto, cuestionan la aplicación práctica de la definición estándar de desempleo de la OIT al caso colombiano.

  4. Encuadre normativo y empírico para un diagnóstico del trabajo infantil en México (Normative and empirical framework for a diagnose of child labour in Mexico

    Directory of Open Access Journals (Sweden)

    Mónica González Contró

    2012-05-01

    Full Text Available This paper seeks to diagnose the phenomenon of children and adolescent labour in Mexico from the legal and empirical perspective, while expecting to make visible underlying, persistent and oftenly hidden realities. With this framework, we present a general path concerning some legal instruments that allow us to define and categorize the studied phenomenon, and we carry out an empirical analysis from a series of indicators developed in the Module of child labour included in the National Survey of Occupation and Employment raised by National Institute of Statistics and Geography (Instituto Nacional de Estadística y Geografía, INEGI in 2009. Information and analyzed data allow us to conclude in a broad manner that the constitutional and legal prohibition to child labour has not fulfill its eradication, further more, not starting from the approach of rights has implied a position of more vulnerability to underage persons who work due to several circumstances, whether economical, social or cultural. En este trabajo se busca realizar una aproximación diagnóstica al fenómeno del trabajo infantil y adolescente en México con miras a visibilizar aspectos que han estado invisibilizados a lo largo del tiempo, desde la perspectiva legal y empírica. En este marco, se hace un recorrido general de algunos instrumentos legales que permiten definir y categorizar el fenómeno, y se realiza un análisis empírico a partir de una serie de indicadores surgidos del Módulo de Trabajo Infantil incluido en la Encuesta Nacional de Ocupación y Empleo levantada por el Instituto Nacional de Estadística y Geografía en el año 2009. La información manejada, así como los datos analizados permiten concluir de manera general que la prohibición constitucional y legal del trabajo infantil no ha conseguido su erradicación, y el no partir de un enfoque de derechos colocaría en una posición de mayor vulnerabilidad a las personas menores de edad que trabajan por

  5. SNMR pulse sequence phase cycling

    Science.gov (United States)

    Walsh, David O; Grunewald, Elliot D

    2013-11-12

    Technologies applicable to SNMR pulse sequence phase cycling are disclosed, including SNMR acquisition apparatus and methods, SNMR processing apparatus and methods, and combinations thereof. SNMR acquisition may include transmitting two or more SNMR pulse sequences and applying a phase shift to a pulse in at least one of the pulse sequences, according to any of a variety cycling techniques. SNMR processing may include combining SNMR from a plurality of pulse sequences comprising pulses of different phases, so that desired signals are preserved and indesired signals are canceled.

  6. The Earth Microbiome Project: Meeting report of the "1 EMP meeting on sample selection and acquisition" at Argonne National Laboratory October 6 2010.

    Science.gov (United States)

    Gilbert, Jack A; Meyer, Folker; Jansson, Janet; Gordon, Jeff; Pace, Norman; Tiedje, James; Ley, Ruth; Fierer, Noah; Field, Dawn; Kyrpides, Nikos; Glöckner, Frank-Oliver; Klenk, Hans-Peter; Wommack, K Eric; Glass, Elizabeth; Docherty, Kathryn; Gallery, Rachel; Stevens, Rick; Knight, Rob

    2010-12-25

    This report details the outcome the first meeting of the Earth Microbiome Project to discuss sample selection and acquisition. The meeting, held at the Argonne National Laboratory on Wednesday October 6(th) 2010, focused on discussion of how to prioritize environmental samples for sequencing and metagenomic analysis as part of the global effort of the EMP to systematically determine the functional and phylogenetic diversity of microbial communities across the world.

  7. Algunos resultados empíricos de la serie "Gasto Público" para el periodo de la guerra civil española

    OpenAIRE

    Samamed Rodríguez, Mª Obdulia

    1986-01-01

    Se presenta la forma en que se han construido, por medios empíricos, los valores más probables de los datos que corresponden a los años de la guerra civil (periodo 1936-39). La metodología utilizada toma como base el análisis de BOX - JENKINS (B/J) de series temporales siendo un instrumento para el análisis de regresión y sus extensiones.

  8. A teoria da lógica mental: e os estudos empíricos em crianças e adultos

    Directory of Open Access Journals (Sweden)

    Dias Maria da Graça Bompastor Borges

    2003-01-01

    Full Text Available Discorremos sobre a teoria da lógica mental como hoje se apresenta, as controvérsias oriundas dos estudos que utilizam a Tabela de Verdade da Lógica Padrão e os estudos empíricos com crianças e adultos que dão suporte à lógica proposicional e à lógica predicativa.

  9. La educación de posgrado en España. Un estudio empírico de la estructura de motivaciones latentes

    Directory of Open Access Journals (Sweden)

    Joaquín Sánchez Herrera

    2009-12-01

    Full Text Available En este trabajo empírico se analiza la estructura de motivaciones que tienen los estudiantes hacia los estudios de posgrado, para poder describir las diferencias que existen entre ellos. Para esto se utiliza el análisis de clases latentes, cuyo resultado muestra tres grupos claramente separados en términos motivacionales, que exigen un tratamiento particular desde la perspectiva de las escuelas de negocios y universidades.

  10. B-cell epitopes in NTS-DBL1α of PfEMP1 recognized by human antibodies in Rosetting Plasmodium falciparum.

    Directory of Open Access Journals (Sweden)

    Letusa Albrecht

    Full Text Available Plasmodium falciparum is the most lethal of the human malaria parasites. The virulence is associated with the capacity of the infected red blood cell (iRBC to sequester inside the deep microvasculature where it may cause obstruction of the blood-flow when binding is excessive. Rosetting, the adherence of the iRBC to uninfected erythrocytes, has been found associated with severe malaria and found to be mediated by the NTS-DBL1α-domain of Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1. Here we show that the reactivity of plasma of Cameroonian children with the surface of the FCR3S1.2-iRBC correlated with the capacity to disrupt rosettes and with the antibody reactivity with a recombinant PfEMP1 (NTS-DBL1α of IT4var60 expressed by parasite FCR3S1.2. The plasma-reactivity in a microarray, consisting of 96 overlapping 15-mer long peptides covering the NTS-DBL1α domain from IT4var60 sequence, was compared with their capacity to disrupt rosettes and we identified five peptides where the reactivity were correlated. Three of the peptides were localized in subdomain-1 and 2. The other two peptide-sequences were localized in the NTS-domain and in subdomain-3. Further, principal component analysis and orthogonal partial least square analysis generated a model that supported these findings. In conclusion, human antibody reactivity with short linear-peptides of NTS-DBL1α of PfEMP1 suggests subdomains 1 and 2 to hold anti-rosetting epitopes recognized by anti-rosetting antibodies. The data suggest rosetting to be mediated by the variable areas of PfEMP1 but also to involve structurally relatively conserved areas of the molecule that may induce biologically active antibodies.

  11. B-cell epitopes in NTS-DBL1α of PfEMP1 recognized by human antibodies in Rosetting Plasmodium falciparum.

    Science.gov (United States)

    Albrecht, Letusa; Angeletti, Davide; Moll, Kirsten; Blomqvist, Karin; Valentini, Davide; D'Alexandri, Fabio Luiz; Maurer, Markus; Wahlgren, Mats

    2014-01-01

    Plasmodium falciparum is the most lethal of the human malaria parasites. The virulence is associated with the capacity of the infected red blood cell (iRBC) to sequester inside the deep microvasculature where it may cause obstruction of the blood-flow when binding is excessive. Rosetting, the adherence of the iRBC to uninfected erythrocytes, has been found associated with severe malaria and found to be mediated by the NTS-DBL1α-domain of Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1). Here we show that the reactivity of plasma of Cameroonian children with the surface of the FCR3S1.2-iRBC correlated with the capacity to disrupt rosettes and with the antibody reactivity with a recombinant PfEMP1 (NTS-DBL1α of IT4var60) expressed by parasite FCR3S1.2. The plasma-reactivity in a microarray, consisting of 96 overlapping 15-mer long peptides covering the NTS-DBL1α domain from IT4var60 sequence, was compared with their capacity to disrupt rosettes and we identified five peptides where the reactivity were correlated. Three of the peptides were localized in subdomain-1 and 2. The other two peptide-sequences were localized in the NTS-domain and in subdomain-3. Further, principal component analysis and orthogonal partial least square analysis generated a model that supported these findings. In conclusion, human antibody reactivity with short linear-peptides of NTS-DBL1α of PfEMP1 suggests subdomains 1 and 2 to hold anti-rosetting epitopes recognized by anti-rosetting antibodies. The data suggest rosetting to be mediated by the variable areas of PfEMP1 but also to involve structurally relatively conserved areas of the molecule that may induce biologically active antibodies.

  12. Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes

    DEFF Research Database (Denmark)

    Jensen, Anja T R; Magistrado, Pamela; Sharp, Sarah;

    2004-01-01

    Parasite-encoded variant surface antigens (VSAs) like the var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic variation and infected red blood cell (RBC) cytoadhesion in P. falciparum malaria. Parasites causing severe malaria...... genes, such as PFD1235w/MAL7P1.1, appear to be involved in the pathogenesis of severe disease and are thus attractive candidates for a vaccine against life-threatening P. falciparum malaria....

  13. Verificación empírica de la curva de Laffer en la economía colombiana (1980 - 2005)

    OpenAIRE

    2008-01-01

    En Colombia se han llevado a cabo varias reformas tributarias las cuales tuvieron como objetivo el aumento de los ingresos tributarios para asegurar el equilibrio de las fi nanzas públicas a corto y mediano plazo. Si bien, las diversas reformas tributarias lograron incrementar los ingresos del gobierno, los efectos de cada una fueron transitorios, lo que han obligado a realizar nuevas reformas. Este trabajo busca evidenciar empíricamente a partir de la curva de Laffer, que dados ...

  14. Pulse distortion in single-mode fibers. 3: Chirped pulses.

    Science.gov (United States)

    Marcuse, D

    1981-10-15

    The theory of pulse distortion in single-mode fibers is extended to include laser sources that suffer a linear wavelength sweep (chirp) during the duration of the pulse. The transmitted pulse is expressed as a Fourier integral whose spectral function is given by an analytical expression in closed form. The rms width of the transmitted pulse is also expressed in closed form. Numerical examples illustrate the influence of the chirp on the shape and rms width of the pulse. A somewhat paradoxical situation exists. A given input pulse can be made arbitrarily short by a sufficiently large amount of chirping, and, after a given fiber length, this chirped pulse returns to its original width. But at this particular distance an unchirped pulse would be only [equiation] times longer. Thus chirping can improve the rate of data transmission by only 40%.

  15. Solid-state pulse forming module with adjustable pulse duration

    Science.gov (United States)

    Wang, Langning; Liu, Jinliang; Qiu, Yongfeng; Chu, Xu; Zhang, Qingmeng

    2017-03-01

    A new solid-state pulse forming module is described in this paper. The pulse forming module is fabricated on a glass ceramic substrate, with the dimension of 250 mm × 95 mm × 4 mm. By changing the copper strips used in the pulse forming modules, the pulse duration of the obtained pulsed can range from 80 ns to 140 ns. Both the simulation and tests show that the pulse forming module has a good pulse forming ability. Under a high voltage in microsecond's time, the new pulse forming modules can hold off a voltage up to 25 kV higher than that of the previous study. In addition, future optimization for the field enhancement near the thin electrode edge has been proposed and simulated.

  16. Ultrafast optomechanical pulse picking

    Science.gov (United States)

    Lilienfein, Nikolai; Holzberger, Simon; Pupeza, Ioachim

    2017-01-01

    State-of-the-art optical switches for coupling pulses into and/or out of resonators are based on either the electro-optic or the acousto-optic effect in transmissive elements. In high-power applications, the damage threshold and other nonlinear and thermal effects in these elements impede further improvements in pulse energy, duration, and average power. We propose a new optomechanical switching concept which is based solely on reflective elements and is suitable for switching times down to the ten-nanosecond range. To this end, an isolated section of a beam path is moved in a system comprising mirrors rotating at a high angular velocity and stationary imaging mirrors, without affecting the propagation of the beam thereafter. We discuss three variants of the concept and exemplify practical parameters for its application in regenerative amplifiers and stack-and-dump enhancement cavities. We find that optomechanical pulse picking has the potential to achieve switching rates of up to a few tens of kilohertz while supporting pulse energies of up to several joules.

  17. Pulsed electric fields

    Science.gov (United States)

    The concept of pulsed electric fields (PEF) was first proposed in 1967 to change the behavior or microorganisms. The electric field phenomenon was identified as membrane rupture theory in the 1980s. Increasing the membrane permeability led to the application of PEF assisted extraction of cellular co...

  18. Pulsed inductive HF laser

    Energy Technology Data Exchange (ETDEWEB)

    Razhev, A M; Kargapol' tsev, E S [Institute of Laser Physics, Siberian Branch, Russian Academy of Sciences, Novosibirsk (Russian Federation); Churkin, D S; Demchuk, S V [Novosibirsk State University, Novosibirsk (Russian Federation)

    2016-03-31

    We report the results of experimentally investigated dependences of temporal, spectral and spatial characteristics of an inductive HF-laser generation on the pump conditions. Gas mixtures H{sub 2} – F{sub 2}(NF{sub 3} or SF6{sub 6}) and He(Ne) – H{sub 2} – F{sub 2}(NF{sub 3} or SF{sub 6}) were used as active media. The FWHM pulse duration reached 0.42 μs. This value corresponded to a pulsed power of 45 kW. For the first time, the emission spectrum of an inductive HF laser was investigated, which consisted of seven groups of bands with centres around the wavelengths of 2732, 2736, 2739, 2835, 2837, 2893 and 2913 nm. The cross section profile of the laser beam was a ring with a diameter of about 20 mm and width of about 5 mm. Parameters of laser operation in the repetitively pulsed regime were sufficiently stable. The amplitude instability of light pulses was no greater than 5% – 6%. (lasers)

  19. Downhole pulse tube refrigerators

    Energy Technology Data Exchange (ETDEWEB)

    Swift, G.; Gardner, D. [Los Alamos National Lab., NM (United States). Condensed Matter and Thermal Physics Group

    1997-12-01

    This report summarizes a preliminary design study to explore the plausibility of using pulse tube refrigeration to cool instruments in a hot down-hole environment. The original motivation was to maintain Dave Reagor`s high-temperature superconducting electronics at 75 K, but the study has evolved to include three target design criteria: cooling at 30 C in a 300 C environment, cooling at 75 K in a 50 C environment, cooling at both 75 K and 30 C in a 250 C environment. These specific temperatures were chosen arbitrarily, as representative of what is possible. The primary goals are low cost, reliability, and small package diameter. Pulse-tube refrigeration is a rapidly growing sub-field of cryogenic refrigeration. The pulse tube refrigerator has recently become the simplest, cheapest, most rugged and reliable low-power cryocooler. The authors expect this technology will be applicable downhole because of the ratio of hot to cold temperatures (in absolute units, such as Kelvin) of interest in deep drilling is comparable to the ratios routinely achieved with cryogenic pulse-tube refrigerators.

  20. A Finite Element Analysis of EMP Journal Bearing%EMP径向滑动轴承弹性变形的有限元求解

    Institute of Scientific and Technical Information of China (English)

    张国贤; 金楗; 吴白羽

    2000-01-01

    Since special properties of synthetic material uses in pad of the EMP journal bearing, the elastic deformation and thenno-deformation will be larger than that of traditional bearing with metal pad. This paper puts the emphasis on the elastic deformation. Compares the result obtained by using the finite element method with that obtained by using Winkler assumption. At last, an example is given to prove the lubrication per formance of EMP journal bearing.%轴瓦材料的特殊性使弹性金属塑料瓦(EMP)径向滑动轴承的热弹变形远大于普通金属瓦轴承,本文着重分析其弹性变形对轴承润滑特性的影响。并对采用三维有限元法和Winkler假设方法计算得出的轴瓦弹性变形进行了比较。给出了EMP径向滑动轴承弹性变形分析研究的一个实例,对其润滑特性进行了初步分析。

  1. Sequentially pulsed traveling wave accelerator

    Science.gov (United States)

    Caporaso, George J.; Nelson, Scott D.; Poole, Brian R.

    2009-08-18

    A sequentially pulsed traveling wave compact accelerator having two or more pulse forming lines each with a switch for producing a short acceleration pulse along a short length of a beam tube, and a trigger mechanism for sequentially triggering the switches so that a traveling axial electric field is produced along the beam tube in synchronism with an axially traversing pulsed beam of charged particles to serially impart energy to the particle beam.

  2. Bacterial inactivation using pulsed light

    OpenAIRE

    Elmnasser, Noura; Ritz, Magali; Leroi, Francoise; Orange, Nicole; Bakhrouf, Amina; Federighi, Michel

    2007-01-01

    Pulsed light is a new method intended for the decontamination of food surfaces using short, high frequency pulses of an intense broad spectrum. The effects of broad spectrum pulsed light on the survival of Listeria monocytogenes Scott A, Listeria monocytogenes CNL, Pseudomonas fluorescens MF37 and Photobacterium phosphoreum SF680 populations on agar and in a liquid medium were investigated during this study. The sterilisation system generated 1.5 J cm(-2) per pulse with eight lamps for 300 mu...

  3. Performance Financeira Corporativa e Performance Social Corporativa: desenvolvimento metodológico e contribuição teórica dos estudos empíricos

    Directory of Open Access Journals (Sweden)

    João Maurício Gama Boaventura

    2012-12-01

    Full Text Available Um dos papéis da contabilidade é prover informações sobre o desempenho empresarial, quer seja por indicadores contábil-financeiros ou não. Dentro deste escopo do interesse da contabilidade, observa-se que a publicação de estudos teórico-empíricos sobre as relações entre Performance Corporativa Financeira (CFP e a Performance Social Corporativa (CSP vem crescendo nos últimos anos, sintoma do desenvolvimento deste campo de pesquisa. Entretanto, a contribuição à teoria pelos trabalhos empíricos se faz de forma pontual, uma vez que normalmente cada estudo foca um aspecto particular da teoria. Periodicamente, portanto, é necessária uma análise que avalie como, de forma agregada, os estudos empíricos contribuíram para a evolução da teoria, e elaborar essa análise constituiu o objetivo do presente estudo. O referencial teórico abrangeu: teoria dos stakeholders, relação entre CSP e CFP, good management theory e slack resource theory. Esta pesquisa abrangeu um período de 15 anos (1996 a 2010 e a coleta de dados empregou a ferramenta de busca das bases de dados: Ebsco, Proquest e ISI. O processo de amostragem obteve um conjunto de 58 artigos exclusivamente teórico-empíricos quantitativos que testam a relação CSP-CFP. Os principais resultados no campo teórico demonstram um reforço da proposição de relação positiva entre CSP e CFP e da good management theory, uma deficiência na explicação na defasagem de tempo (lag na relação de causalidade entre CSP e CFP, e deficiências na descrição do constructo de CSP. Isto sugere estudos futuros para investigar a defasagem de tempo na relação de causalidade entre CSP e CFP e as possíveis razões que levaram diversos estudos empíricos a não atestarem uma associação positiva entre CSP e CFP.

  4. Applications of ultra-short pulsed laser ablation: thin films deposition and fs/ns dual-pulse laser-induced breakdown spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Teghil, R; De Bonis, A; Galasso, A [Dipartimento di Chimica, Universita della Basilicata, Via N. Sauro 85, 85100 Potenza (Italy); Santagata, A; Albano, G; Villani, P; Spera, D; Parisi, G P [CNR-IMIP, Unita di Potenza, Via S. Loja, 85050 Tito Scalo (Italy)], E-mail: roberto.teghil@unibas.it

    2008-10-15

    In this paper, we report a survey of two of the large number of possible practical applications of the laser ablation performed by an ultra-short pulse laser, namely pulsed laser deposition (PLD) and fs/ns dual-pulse laser-induced breakdown spectroscopy (DP-LIBS). These applications differ from those using just longer pulsed lasers as a consequence of the distinctive characteristics of the plasma produced by ultra-short laser beams. The most important feature of this plasma is the large presence of particles with nanometric size which plays a fundamental role in both applications.

  5. The Effect of Ionospheric Models on Electromagnetic Pulse Locations

    Energy Technology Data Exchange (ETDEWEB)

    Fenimore, Edward E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Triplett, Laurie A. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-07-01

    Locations of electromagnetic pulses (EMPs) determined by time-of-arrival (TOA) often have outliers with significantly larger errors than expected. In the past, these errors were thought to arise from high order terms in the Appleton-Hartree equation. We simulated 1000 events randomly spread around the Earth into a constellation of 22 GPS satellites. We used four different ionospheres: “simple” where the time delay goes as the inverse of the frequency-squared, “full Appleton-Hartree”, the “BobRD integrals” and a full raytracing code. The simple and full Appleton-Hartree ionospheres do not show outliers whereas the BobRD and raytracing do. This strongly suggests that the cause of the outliers is not additional terms in the Appleton-Hartree equation, but rather is due to the additional path length due to refraction. A method to fix the outliers is suggested based on fitting a time to the delays calculated at the 5 GPS frequencies with BobRD and simple ionospheres. The difference in time is used as a correction to the TOAs.

  6. A THERMAL PULSE SHAPER MECHANISM.

    Science.gov (United States)

    A shaped pulse of intense thermal radiation, corresponding to the pulses from nuclear weapons, is obtained by the output of a QM carbon arc. A flywheel driven by a DC motor actuated a venetian blind shutter placed between a mirror and the target to control the flux. The combination produced reasonably good simulation and reproduction of the generalized field pulse.

  7. Construcción empírica de la homoparentalidad: necesidad de una aproximación cualitativa

    Directory of Open Access Journals (Sweden)

    Laura Domínguez de la Rosa

    2016-05-01

    Full Text Available Este artículo tiene como objetivo mostrar los estudios más relevantes que, desde distintas disciplinas de las ciencias sociales, se han realizado sobre la parentalidad gay y lesbiana tanto en Europa como en América. Hasta la década del 2000 los estudios prohomoparentales eran principalmente de carácter cuantitativo y se centraban en premisas heterocentradas, es decir, en comparar la competencia parental y ajuste psicosocial «normal» de los niños criados en familias heteroparentales con los niños criados en familias homoparentales. Este tipo de investigaciones han apostado por normalizar y asimilar el fenómeno homoparental a la experiencia de paternidad y maternidad en relaciones heterosexuales. De esta forma, consideramos que en el proceso de construcción social de la homoparentalidad existe un predominio de recursos básicos privilegiados normalizadores, a la vez que se difuminan experiencias y matices que pudieran contribuir a un conocimiento del fenómeno más fértil en su reflejo sobre la acción legislativa, política y social. Así, planteamos la necesidad de consolidar una agenda empírica alternativa de naturaleza cualitativa cuyo objetivo sea indagar sobre qué planteamientos se están construyendo social y culturalmente las dinámicas familiares de normalización e innovación social en torno a estas nuevas experiencias de convivencia.

  8. Determinantes multidimensionales en la calidad percibida del empleo. Evidencia empírica para España

    Directory of Open Access Journals (Sweden)

    Díaz-Chao, Ángel

    2015-04-01

    Full Text Available Through a representative sample of 8.755 employees in 2010, and using a structural equations model (SEM, this article analyzes empirically the multidimensional determinants (direct effects of the perceived work quality in Spain. The research concludes that the perceived work quality combines a broad set of explanatory dimensions that are linked with de workplace itself (intrinsic work quality, organization, access and inclusion, and compensations, but also with their environment and labor relations (social relations, work intensity, skills and training, and health and safety. Therefore, the public employment policies for ending the economic crisis should not only address the quality or workplace, but also meet the dimensions related to their environment and labor relations.A través de una muestra representativa para 8.755 empleados asalariados en 2010, y utilizando un sistema de ecuaciones estructurales, este artículo analiza empíricamente los determinantes multidimensionales (efectos directos de la calidad percibida del empleo en España. La investigación concluye que la calidad del empleo combina un amplio conjunto de dimensiones explicativas que están vinculadas con el propio puesto de trabajo (calidad intrínseca, organización, inclusión y acceso y compensación, pero también con su entorno y las relaciones laborales (relaciones sociales, intensidad del empleo, formación, y salud y seguridad en el trabajo. Por consiguiente, las políticas públicas de empleo para la salida de la crisis no solo deberían abordar la calidad del puesto de trabajo, sino también atender a las dimensiones vinculadas con su entorno y las relaciones laborales.

  9. Criminologia e Prisão: caminhos e desafios da pesquisa empírica no campo prisional

    Directory of Open Access Journals (Sweden)

    Ana Gabriela Mendes Braga

    2014-01-01

    Full Text Available O presente artigo é um dos frutos da pesquisa de doutoramento “Reintegração social: discursos e práticas na prisão ‒ um estudo comparado”, na qual foram analisados alguns projetos desenvolvidos por entidades da sociedade civil em estabelecimentos prisionais de São Paulo e da Catalunha (Espanha. Para tanto, utilizou-se metodologia qualitativa de pesquisa, com o emprego de três métodos: entrevistas semidirigidas com os envolvidos direta e indiretamente com os projetos (voluntários, presos, diretores de entidades, funcionários da prisão; pesquisa documental (projetos, memoriais, manuais; e, relatos etnográficos produzidos a partir da observação in loco do trabalho desenvolvido pelas entidades selecionadas nos estabelecimentos prisionais. Neste paper, ganha destaque a questão do método em criminologia e as reflexões acerca da pesquisa empírica na prisão. Em uma pesquisa situada em um espaço tão hermético como a prisão, explicitar os caminhos de inserção do campo é um exercício que desvela os mecanismos de poder em funcionamento, e acaba por levar o pesquisador de volta ao objeto da própria tese. Afinal, muitos dos empecilhos e barreiras criadas para a entrada do pesquisador na prisão são os mesmos com que se deparam as entidades e pessoas da sociedade civil. Esse artigo é uma reflexão acerca dos caminhos e dos desafios vivenciados por aqueles que adentram o espaço prisional enfrentando o isolamento impostos por seus muros.

  10. Problemas na mensuração da estrutura de capital: evidências empíricas no Brasil

    Directory of Open Access Journals (Sweden)

    Márcio André Veras Machado

    2010-01-01

    Full Text Available Este artigo, empírico-analítico, teve por objetivo verificar se a estrutura de capital é sensível às medidas utilizadas para mensurar a alavancagem. Buscou-se, também, verificar se maior parte da variabilidade na alavancagem é devida à variabilidade do Passivo Oneroso. A amostra consistiu de todas as empresas nãofinanceiras com disponibilidade de dados, patrimônio líquido positivo e com ações listadas na Bovespa entre 1995 e 2007, totalizando, em média, 133 empresas por ano. Os dados necessários para análise foram extraídos do banco de dados da Economática. Para análise dos dados, fez-se uso da regressão linear em cross-section, de modo a estimar os coeficientes e demais estatísticas de interesse, seguindo a metodologia de Fama e MacBeth (1973. Como resultados principais, tem-se que mais da metade da heterogeneidade cross-seccional do índice de alavancagem é proveniente de variações no índice PNO/AT. No que diz respeito à sensibilidade às medidas utilizadas para mensurar a alavancagem, conclui-se que a variável lucratividade foi a única que se mostrou razoavelmente consistente, em termos de magnitude, sinal e significância, com as diferentes medidas de alavancagem utilizadas.

  11. Barriers and Opportunities to Serving Pulses in School Meals in Washington Schools

    Science.gov (United States)

    Smith, Diane K.; Riddle, Lee Anne; Kerr, Susan; Atterberry, Kelly; Lanigan, Jane; Miles, Carol

    2016-01-01

    Pulses are nutritionally important grain legumes that include dry beans, dry peas, garbanzo beans, and lentils. Schools are required to offer one-half cup pulses per week for each student participating in the National School Lunch Program [NSLP]. A survey of school nutrition directors and nutrition specialists was administered in Washington State…

  12. Barriers and Opportunities to Serving Pulses in School Meals in Washington Schools

    Science.gov (United States)

    Smith, Diane K.; Riddle, Lee Anne; Kerr, Susan; Atterberry, Kelly; Lanigan, Jane; Miles, Carol

    2016-01-01

    Pulses are nutritionally important grain legumes that include dry beans, dry peas, garbanzo beans, and lentils. Schools are required to offer one-half cup pulses per week for each student participating in the National School Lunch Program [NSLP]. A survey of school nutrition directors and nutrition specialists was administered in Washington State…

  13. Noisy homoclinic pulse dynamics

    Science.gov (United States)

    Eaves, T. S.; Balmforth, Neil J.

    2016-04-01

    The effect of stochastic perturbations on nearly homoclinic pulse trains is considered for three model systems: a Duffing oscillator, the Lorenz-like Shimizu-Morioka model, and a co-dimension-three normal form. Using the Duffing model as an example, it is demonstrated that the main effect of noise does not originate from the neighbourhood of the fixed point, as is commonly assumed, but due to the perturbation of the trajectory outside that region. Singular perturbation theory is used to quantify this noise effect and is applied to construct maps of pulse spacing for the Shimizu-Morioka and normal form models. The dynamics of these stochastic maps is then explored to examine how noise influences the sequence of bifurcations that take place adjacent to homoclinic connections in Lorenz-like and Shilnikov-type flows.

  14. Computationally intelligent pulsed photoacoustics

    Science.gov (United States)

    Lukić, Mladena; Ćojbašić, Žarko; Rabasović, Mihailo D.; Markushev, Dragan D.

    2014-12-01

    In this paper, the application of computational intelligence in pulsed photoacoustics is discussed. Feedforward multilayer perception networks are applied for real-time simultaneous determination of the laser beam spatial profile and vibrational-to-translational relaxation time of the polyatomic molecules in gases. Networks are trained and tested with theoretical data adjusted for a given experimental set-up. Genetic optimization has been used for calculation of the same parameters, fitting the photoacoustic signals with a different number of generations. Observed benefits from the application of computational intelligence in pulsed photoacoustics and advantages over previously developed methods are discussed, such as real-time operation, high precision and the possibility of finding solutions in a wide range of parameters, similar to in experimental conditions. In addition, the applicability for practical uses, such as the real-time in situ measurements of atmospheric pollutants, along with possible further developments of obtained results, is argued.

  15. Micro pulse laser radar

    Science.gov (United States)

    Spinhirne, James D. (Inventor)

    1993-01-01

    An eye safe, compact, solid state lidar for profiling atmospheric cloud and aerosol scattering is disclosed. The transmitter of the micro pulse lidar is a diode pumped micro-J pulse energy, high repetition rate Nd:YLF laser. Eye safety is obtained through beam expansion. The receiver employs a photon counting solid state Geiger mode avalanche photodiode detector. Data acquisition is by a single card multichannel scaler. Daytime background induced quantum noise is controlled by a narrow receiver field-of-view and a narrow bandwidth temperature controlled interference filter. Dynamic range of the signal is limited to optical geometric signal compression. Signal simulations and initial atmospheric measurements indicate that micropulse lider systems are capable of detecting and profiling all significant cloud and aerosol scattering through the troposphere and into the stratosphere. The intended applications are scientific studies and environmental monitoring which require full time, unattended measurements of the cloud and aerosol height structure.

  16. Magnetic Pulse Welding Technology

    Directory of Open Access Journals (Sweden)

    Ahmad K. Jassim

    2011-12-01

    Full Text Available In this paper, the benefits of using Magnetic Pulse machine which is belong to Non-conventional machine instead of conventional machine. Magnetic Pulse Technology is used for joining dissimilar metals, and for forming and cutting metals. It is a non contact technique. Magnetic field is used to generate impact magnetic pressure for welding and forming the work piece by converted the electrical energy to mechanical energy. It is enable us to design previously not possible by welding dissimilar materials and allowing to welds light and stronger materials together. It can be used to weld metallic with non metallic materials to created mechanical lock on ceramics, polymers, rubbers and composites. It is green process; there is no heat, no radiation, no gas, no smoke and sparks, therefore the emissions are negligible.

  17. Measurement of pulse lengthening with pulse energy increase in picosecond Nd:YAG laser pulses

    Energy Technology Data Exchange (ETDEWEB)

    Cutolo, A.; Zeni, L.; Berardi, V.; Bruzzese, R.; Solimeno, S.; Spinelli, N.

    1989-03-15

    Taking advantage of a new technique, we have monitored the relative variations of time duration and mode size as a function of the pulse energy for 30-ps-long Nd:YAG laser pulses. In particular, by carrying out a statistical analysis, we have observed that the pulse time duration is an increasing function of the pulse energy, according to the theoretical modeling of passively mode-locked lasers. The measurements can be easily extended to the femtosecond regime.

  18. Twitter's visual pulse

    OpenAIRE

    Hare, Jonathon; Samangooei, Sina; Dupplaw, David; Lewis, Paul H.

    2013-01-01

    Millions of images are tweeted every day, yet very little research has looked at the non-textual aspect of social media communication. In this work we have developed a system to analyse streams of image data. In particular we explore trends in similar, related, evolving or even duplicated visual artefacts in the mass of tweeted image data — in short, we explore the visual pulse of Twitter.

  19. Pulse Portraiture: Pulsar timing

    Science.gov (United States)

    Pennucci, Timothy T.; Demorest, Paul B.; Ransom, Scott M.

    2016-06-01

    Pulse Portraiture is a wideband pulsar timing code written in python. It uses an extension of the FFTFIT algorithm (Taylor 1992) to simultaneously measure a phase (TOA) and dispersion measure (DM). The code includes a Gaussian-component-based portrait modeling routine. The code uses the python interface to the pulsar data analysis package PSRCHIVE (ascl:1105.014) and also requires the non-linear least-squares minimization package lmfit (ascl:1606.014).

  20. STUCTURE OF PULSED BED

    Directory of Open Access Journals (Sweden)

    I. A. Bokun

    2014-01-01

    Full Text Available The structure of pulsed layer is proposed which can be suggested as a state of particulates that is blown by intermittent gas flow with speed which has the force to start material moving. Layer during one cycle is in a suspension, falling down and immobile state resulting in changes of particles arrangement as well as ways of gas flowing through layer. Moreover, it allows carrying out effective interphase heat exchange even adamant real granulation.The process of formation of impact flows is considered aw well as their influence on formation of air bubbles in pulsed layer. At startup of air blast the balance between the force of hydro-dynamic resistance is broken, on one side, and forces of gravity, particles inertia and their links with walls on the other side. The layer is transferred in the state of pulsed pseudo-fluidization, and presents gas-disperse mixture, inside of which impulse of pressure increasing is spreading to all sides as pressure waves (compression. These waves are the sources of impact flows’ formation, the force of which is two times more than during the stationary flow.The waves of pressure are divided into weak and strong ones depending on movement velocity within gas-disperse system. Weak waves are moving with a sound speed and strong ones in active phase of pulsed layer are moving over the speed of sound limit within gas-disperse system. The peculiarity of strong wave is that parameters of system (pressure, density and others are changing in discrete steps.The article describes the regime of layer’s falling down in the passive stage of cycle, which begins after finishing of gas impulse action. And suspension layer of moving up granular material is transferred in the state of falling resulting in change of the layer structure.

  1. Downhole pulse radar

    Science.gov (United States)

    Chang, Hsi-Tien

    1987-09-28

    A borehole logging tool generates a fast rise-time, short duration, high peak-power radar pulse having broad energy distribution between 30 MHz and 300 MHz through a directional transmitting and receiving antennas having barium titanate in the electromagnetically active region to reduce the wavelength to within an order of magnitude of the diameter of the antenna. Radar returns from geological discontinuities are sampled for transmission uphole. 7 figs.

  2. Ptychographic ultrafast pulse reconstruction

    CERN Document Server

    Spangenberg, D; Brügmann, M H; Feurer, T

    2014-01-01

    We demonstrate a new ultrafast pulse reconstruction modality which is somewhat reminiscent of frequency resolved optical gating but uses a modified setup and a conceptually different reconstruction algorithm that is derived from ptychography. Even though it is a second order correlation scheme it shows no time ambiguity. Moreover, the number of spectra to record is considerably smaller than in most other related schemes which, together with a robust algorithm, leads to extremely fast convergence of the reconstruction.

  3. PULSE Pilot Certification Results

    Directory of Open Access Journals (Sweden)

    Pamela Pape-Lindstrom

    2015-08-01

    Full Text Available The pilot certification process is an ambitious, nationwide endeavor designed to motivate important changes in life sciences education that are in line with the recommendations of the 2011 Vision and Change Report: A Call to Action (American Association for the Advancement of Science [AAAS], 2011.  It is the goal of the certification process to acknowledge departments that have progressed towards full implementation of the tenets of Vision and Change and to motivate departments that have not begun to adopt the recommendations to consider doing so.  More than 70 life science departments applied to be part of the pilot certification process, funded by a National Science Foundation grant, and eight were selected based on initial evidence of transformed and innovative educational practices.  The programs chosen represent a wide variety of schools, including two-year colleges, liberal-arts institutions, regional comprehensive colleges, research universities and minority serving institutions.  Outcomes from this pilot were released June 1, 2015 (www.pulsecommunity.org, with all eight programs being recognized as having progressed along a continuum of change.  Five levels of achievement were defined as PULSE Pilot Progression Levels.  Of the eight departments in the pilot, one achieved “PULSE Progression Level III: Accomplished”.  Six departments achieved “PULSE Progression Level II: Developing” and one pilot department achieved “PULSE Progression Level I: Beginning”.  All of the schools have made significant movement towards the recommendations of Vision and Change relative to a traditional life sciences curriculum.  Overall, the response from the eight pilot schools has been positive. 

  4. Uses of pulsed electron beam to solid-states studies

    Energy Technology Data Exchange (ETDEWEB)

    Itoh, Noriaki; Nakayama, Takeyoshi; Tanimura, Katsumi; Chong, Taisu; Saidoh, Masahiro

    1982-03-01

    A survey is given on the use of the pulsed electron beams to studies of solid states. Even though main emphasis is placed on the studies carried out at the Faculty of Engineering, Nagoya University, using the Pulsed Electron Facilities installed in 1970, the works carried out at other institutes are also included. Only the studies of crystalline solids with simple structures, such as alkali halides and aromatic hydrocarbons are covered. In the first place several instrumentations which have extended utilities of pulsed-electron beams are presented. Then we discuss the studies of the dynamic of excitons, emphasizing the advantages and disadvantages of the usage of the electron pulses. Then usages of the pulsed-electron beam for the studies of the excited states of the quasi-stable defects are described. Application of the electron pulse for studies of the excitation spectroscopy of the photochemistry is described. The dynamic studies of defects introduced by electron-pulse bombardment is discussed finally. A summary is given, which includes also the possible future experiments.

  5. Petawatt pulsed-power accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Stygar, William A. (Albuquerque, NM); Cuneo, Michael E. (Albuquerque, NM); Headley, Daniel I. (Albuquerque, NM); Ives, Harry C. (Albuquerque, NM); Ives, legal representative; Berry Cottrell (Albuquerque, NM); Leeper, Ramon J. (Albuquerque, NM); Mazarakis, Michael G. (Albuquerque, NM); Olson, Craig L. (Albuquerque, NM); Porter, John L. (Sandia Park, NM); Wagoner; Tim C. (Albuquerque, NM)

    2010-03-16

    A petawatt pulsed-power accelerator can be driven by various types of electrical-pulse generators, including conventional Marx generators and linear-transformer drivers. The pulsed-power accelerator can be configured to drive an electrical load from one- or two-sides. Various types of loads can be driven; for example, the accelerator can be used to drive a high-current z-pinch load. When driven by slow-pulse generators (e.g., conventional Marx generators), the accelerator comprises an oil section comprising at least one pulse-generator level having a plurality of pulse generators; a water section comprising a pulse-forming circuit for each pulse generator and a level of monolithic triplate radial-transmission-line impedance transformers, that have variable impedance profiles, for each pulse-generator level; and a vacuum section comprising triplate magnetically insulated transmission lines that feed an electrical load. When driven by LTD generators or other fast-pulse generators, the need for the pulse-forming circuits in the water section can be eliminated.

  6. Pulse Distributing Manifold; Pulse Distributing Manifold

    Energy Technology Data Exchange (ETDEWEB)

    Schutting, Eberhard [Technische Univ. Graz (Austria); Sams, Theodor [AVL List GmbH, Graz (Austria); Glensvig, Michael [Forschungsgesellschaft mbH, Graz (AT). Kompetenzzentrum ' ' Das virtuelle Fahrzeug' ' (VIF)

    2011-07-01

    The Pulse Distributing Manifold is a new charge exchange method for turbocharged diesel engines with exhaust gas recirculation (EGR). The method is characterized in that the EGR mass flow is not diverted from the exhaust gas mass flow continuously, but over time broken into sub-streams. The temporal interruption is achieved by two phase-shifted outlet valves which are connected via separate manifolds only with the turbocharger or only with the EGR path. The time points of valve opening are chosen such that the turbocharger and the aftertreatment process of exhaust gas is perfused by high-energy exhaust gas of the blowdown phase while cooler and less energy-rich exhaust gas of the exhaust period is used for the exhaust gas recirculation. This increases the enthalpy for the turbocharger and the temperature for the exhaust gas treatment, while the cooling efficiency at the EGR cooler is reduced. The elimination of the continuous EGR valve has a positive effect on pumping losses. The principle functioning and the potential of this system could be demonstrated by means of a concept study using one-dimensional simulations. Without disadvantages in fuel consumption for the considered commercial vehicle engine, a reduction the EGR cooler performance by 15 % and an increase in exhaust temperature of 35 K could be achieved. The presented charge exchange method was developed, evaluated and patented within the scope of the research program 'K2-mobility' of the project partners AVL (Mainz, Federal Republic of Germany) and University of Technology Graz (Austria). The research project 'K2-Mobility' is supported by the competence center 'The virtual vehicle' Forschungsgesellschaft mbH (Graz, Austria).

  7. High-speed pulse-shape generator, pulse multiplexer

    Science.gov (United States)

    Burkhart, Scott C.

    2002-01-01

    The invention combines arbitrary amplitude high-speed pulses for precision pulse shaping for the National Ignition Facility (NIF). The circuitry combines arbitrary height pulses which are generated by replicating scaled versions of a trigger pulse and summing them delayed in time on a pulse line. The combined electrical pulses are connected to an electro-optic modulator which modulates a laser beam. The circuit can also be adapted to combine multiple channels of high speed data into a single train of electrical pulses which generates the optical pulses for very high speed optical communication. The invention has application in laser pulse shaping for inertial confinement fusion, in optical data links for computers, telecommunications, and in laser pulse shaping for atomic excitation studies. The invention can be used to effect at least a 10.times. increase in all fiber communication lines. It allows a greatly increased data transfer rate between high-performance computers. The invention is inexpensive enough to bring high-speed video and data services to homes through a super modem.

  8. Aircraft EMP Isolation Study.

    Science.gov (United States)

    1980-07-01

    Acrylic parameters. 57 11 Specifications: FABCO SA bearing pads. 58 12 Humidity resistant film adhesive for hermetic 59 sealing of microelectronic packages ...PROCESSING Blow, foam, in- jection, rota- tional mldg; extrusion Thermoforming . ’I5 { 56 - .... i Table 10. Acrylic parameters. Type -G General...D150 0.02-0.03 Arc Resistance, sec ...................... No track APPLICABLE PROCESSING METHODS Thermoforming , casting CHEMICAL RESISTANCE Resists

  9. Coiled transmission line pulse generators

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, Kenneth Fox (Columbia, MO)

    2010-11-09

    Methods and apparatus are provided for fabricating and constructing solid dielectric "Coiled Transmission Line" pulse generators in radial or axial coiled geometries. The pour and cure fabrication process enables a wide variety of geometries and form factors. The volume between the conductors is filled with liquid blends of monomers, polymers, oligomers, and/or cross-linkers and dielectric powders; and then cured to form high field strength and high dielectric constant solid dielectric transmission lines that intrinsically produce ideal rectangular high voltage pulses when charged and switched into matched impedance loads. Voltage levels may be increased by Marx and/or Blumlein principles incorporating spark gap or, preferentially, solid state switches (such as optically triggered thyristors) which produce reliable, high repetition rate operation. Moreover, these Marxed pulse generators can be DC charged and do not require additional pulse forming circuitry, pulse forming lines, transformers, or an a high voltage spark gap output switch. The apparatus accommodates a wide range of voltages, impedances, pulse durations, pulse repetition rates, and duty cycles. The resulting mobile or flight platform friendly cylindrical geometric configuration is much more compact, light-weight, and robust than conventional linear geometries, or pulse generators constructed from conventional components. Installing additional circuitry may accommodate optional pulse shape improvements. The Coiled Transmission Lines can also be connected in parallel to decrease the impedance, or in series to increase the pulse length.

  10. Green Light Pulse Oximeter

    Energy Technology Data Exchange (ETDEWEB)

    Scharf, John Edward (Oldsmar, FL)

    1998-11-03

    A reflectance pulse oximeter that determines oxygen saturation of hemoglobin using two sources of electromagnetic radiation in the green optical region, which provides the maximum reflectance pulsation spectrum. The use of green light allows placement of an oximetry probe at central body sites (e.g., wrist, thigh, abdomen, forehead, scalp, and back). Preferably, the two green light sources alternately emit light at 560 nm and 577 nm, respectively, which gives the biggest difference in hemoglobin extinction coefficients between deoxyhemoglobin, RHb, and oxyhemoglobin, HbO.sub.2.

  11. Pulsed differential pumping system

    Energy Technology Data Exchange (ETDEWEB)

    Antipov, G.N.; Bagautdinov, F.A.; Rybalov, S.V.

    1985-06-01

    A pulsed differential pumping system is described for extracting an electron beam from a shaping region at a pressure of 10/sup -5/ torr into a volume with a pressure of 10-100 torr. A fast valve is used with appropriate geometrical parameters to reduce the length of the outlet channel considerable while increasing its diameter. Test results are given. The pumping system has two sections which communicate one with the other and with the volume at the elevated pressure which is produced by gasdynamic nozzles.

  12. Pulse Field Gel Electrophoresis.

    Science.gov (United States)

    Sharma-Kuinkel, Batu K; Rude, Thomas H; Fowler, Vance G

    2016-01-01

    Pulse Field Gel Electrophoresis (PFGE) is a powerful genotyping technique used for the separation of large DNA molecules (entire genomic DNA) after digesting it with unique restriction enzymes and applying to a gel matrix under the electric field that periodically changes direction. PFGE is a variation of agarose gel electrophoresis that permits analysis of bacterial DNA fragments over an order of magnitude larger than that with conventional restriction enzyme analysis. It provides a good representation of the entire bacterial chromosome in a single gel with a highly reproducible restriction profile, providing clearly distinct and well-resolved DNA fragments.

  13. A Pulsed Sphere Tutorial

    Energy Technology Data Exchange (ETDEWEB)

    Cullen, Dermott E. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-01-30

    Here I attempt to explain what physically happens when we pulse an object with neutrons, specifically what we expect the time dependent behavior of the neutron population to look like. Emphasis is on the time dependent emission of both prompt and delayed neutrons. I also describe how the TART Monte Carlo transport code models this situation; see the appendix for a complete description of the model used by TART. I will also show that, as we expect, MCNP and MERCURY, produce similar results using the same delayed neutron model (again, see the appendix).

  14. Evicencia Empírica en Torno al Estudio del Factor Tamaño cono Condicionante Empresarial

    Directory of Open Access Journals (Sweden)

    María Elena Gómez Miranda

    2004-06-01

    Full Text Available En este trabajo presentamos las principales conclusiones obtenidas a través de la realización de un estudio empírico, con el que contrastamos la hipótesis del condicionamiento empresarial por razón de su dimensión. La investigación se ha realizado a través de la aplicación de diversas técnicas de análisis multivariable, concretamente el análisis factorial, cluster y discriminante, sobre la información relativa a una muestra integrada por 6.600 empresas. Para la definición del tamaño empresarial se han tomado como referencia diversos criterios, los cuales están basados en los utilizados por algunas Centrales de Balances españolas para la clasificación y explotación de sus bases de datos. La interpretación de los resultados obtenidos nos permite concluir que las características económico-financieras de las empresas que integran nuestra muestra son independientes de su dimensión, incumpliéndose por tanto la hipótesis del condicionamiento empresarial por razón de su tamaño. In this paper we point out the main conclusions obtained through an empirical study carried out in order to check the hypothesis with regard to firm conditioning in view of its size. The research has been carried out by applying diverse techniques of multivariable analysis, specifically factorial analysis, cluster and discriminant, on the basis of the information available from a sample made up by 6.600 firms. Diverse criteria used by certain Spanish Commercial Performance Information Bureaus to classify and work with their database, have been taken as a reference in the outline of a firms size. According to the analysis of the results obtained, we conclude that the economic and financial characteristics of the firms examined do not depend on their size, and therefore the hypothesis of firm nature according to its size is not confirmed.

  15. Análisis empírico de la financiación de nuevas empresas en Colombia

    Directory of Open Access Journals (Sweden)

    Bernardo Barona-Zuluaga

    2012-03-01

    Full Text Available Este artículo identifica y analiza los patrones de financiación de las empresas nuevas en Colombia. Como marco de referencia se toma la moderna teoría financiera que incorpora los conceptos de asimetría de información y de la economía institucional en el estudio de la estructura financiera y de capital empresariales. En especial, se emplea el concepto desarrollado por Berger y Udell (1998 de que el ciclo de vida en que se encuentra una empresa particular afecta su estructura de capital óptima, y se someten a prueba varias hipótesis respecto a la forma en que se financian las empresas jóvenes colombianas. Para la contrastación empírica de las hipótesis se utiliza una base de datos provista (a solicitud de los investigadores por la Superintendencia de Sociedades de Colombia, de empresas creadas entre los años 1999 y 2007; la muestra depurada quedó conformada por 4.034 empresas, 922 con edad inferior a cinco años (infantes–adolecentes, I&A y 3.112 con existencia mayor a cinco años (mediana edad, EM. Los análisis univariado y multivariado realizados, tomados de manera conjunta, indican que la etapa en el ciclo de vida de una empresa importa en la definición de su estructura de capital: no solo la importancia de las fuentes específicas de financiación es diferente en las dos categorías etarias, sino también algunos de los factores que se relacionan de manera significativa con su estructura financiera. El patrimonio se revela como la fuente de financiación más importante en ambos tipos de categorías; la inversión de los dueños es la partida patrimonial más importante en las I&A, en tanto que las utilidades retenidas lo son en las EM. Tanto el tamaño como la tangibilidad de los activos están relacionados de manera positiva con el porcentaje de apalancamiento de las empresas de los dos grupos estudiados. La rentabilidad se relaciona de manera negativa y significativa con el apalancamiento de las EM. Estos hallazgos tienen

  16. Persistencia y capacidad predictiva de márgenes y rotaciones. Un análisis empírico.

    Directory of Open Access Journals (Sweden)

    Juan Monterrey

    2011-06-01

    Full Text Available ABSTRACTThis paper presents an empirical analysis of the persistence and predictive ability of the components the profitability ratio, namely, margin and turnover. Based on a large sample of Spanish companies, we document that the persistence of turnover is greater than that of profit margin and that abnormal components of both, turnover and margin have a lower degree of persistence when compared to industry components. As for predictive ability, our findings confirm that albeit having a lower persistence, margin has a greater predictive power than turnover. By decomposing margin and turnover into their industry and abnormal components, we confirm that abnormal items have a greater predictive ability than industry components. Additional tests revealed that our findings are robust, although the predictive power of our variables changes depending on their sign as well as in the presence of positive and negative earnings.RESUMENEn el presente trabajo abordamos el estudio empírico de la persistencia y capacidad predictiva de los componentes margen y rotación de la rentabilidad. A partir de una amplia muestra de compañías españolas, hemos documentado cómo la persistencia de la rotación es superior a la del margen, y cómo los componentes anormales de margen y rotación son menos persistentes que sus componentes sectoriales. Con relación a la capacidad predictiva, nuestros hallazgos confirman que el poder de predicción del margen es más elevado que el de la rotación, aunque su persistencia sea menor. Al separar los componentes sectorial y anormal de margen y rotación hemos comprobado cómo los componentes anormales muestran una capacidad predictiva superior a los componentes sectoriales. Los análisis complementarios muestran el distinto poder predictivo según el signo positivo o negativo de márgenes y rotaciones anormales, y según el signo del resultado, así como la robustez de nuestros hallazgos.

  17. Convergência de renda: uma breve revisão dos principais conceitos e trabalhos empíricos

    Directory of Open Access Journals (Sweden)

    Vilmar Nogueira Duarte

    2011-07-01

    Full Text Available Este artigo teve a intenção de apresentar os conceitos mais relevantes relacionados à convergência de renda, no que se refere às convergências absoluta, condicional e clubes de convergência, bem como mostrar o resultado de alguns estudos realizados no Brasil e no mundo sobre o tema. Foi realizado através de um estudo descritivo com base em bibliografias especializadas sobre o assunto e trabalhos empíricos realizados até então. O trabalho mostra que a discussão sobre o tema é um assunto novo na teoria econômica e teve início com estudos desenvolvidos a partir dos anos de 1980. Mostra também que os resultados são bastante divergentes em relação às hipóteses de convergência absoluta, condicional e de clubes, quando se analisa a convergência entre países, o mesmo acontecendo em relação os estados. No caso dos municípios, os estudos apontam para a predominância da hipótese de clubes de convergência em praticamente todos os casos analisados no país. Finalmente conclui que dependendo da metodologia utilizada para os testes e do período considerado para análise, os resultados podem apresentar divergências mesmo quando considerada a mesma amostra, seja ela constituída por países, estados ou municípios.Abstract This article was intended to present the most relevant concepts related to income convergence in the case of absolute convergence, conditional convergence clubs, as well as show the results of some studies in Brazil and worldwide on the topic. It was carried out through a descriptive study based on specialized bibliographies on the subject and empirical work done so far. The work shows that the discussion on the topic is a new subject in economic theory and began with studies developed from the 1980s. It also shows that the results are very different in relation to cases of absolute convergence, conditional and clubs, when analyzing the convergence between countries, as do over the states. In the case of

  18. Testes empíricos sobre o comportamento assimétrico dos custos nas empresas brasileiras

    Directory of Open Access Journals (Sweden)

    Otávio Ribeiro de Medeiros

    2005-08-01

    Full Text Available Este estudo testa e confirma a hipótese de que os custos das empresas brasileiras apresentam elasticidade assimétrica em relação a variações nas receitas, ou seja, que os custos aumentam com maior intensidade quando a receita aumenta do que no sentido oposto, conforme evidências empíricas recentes com empresas norte-americanas. Ao contrário da evidência, no entanto, essa assimetria não parece diminuir quando se consideram períodos maiores do que um exercício. A confirmação de uma possível reversão parcial da assimetria quando se consideram períodos defasados, observada em pesquisas anteriores, é confirmada no estudo. A metodologia utilizada envolve diferentes tipos de regressão em panel data. O artigo pretende contribuir para o melhor conhecimento do comportamento dos custos das empresas brasileiras em relação a variações no seu nível de atividade, tema relevante para a sua administração, para os contadores e para os analistas financeiros externos. Utilizando uma amostra de 198 empresas num período de 17 anos, constatou-se que os modelos de custos assimétricos propostos por Anderson, Banker e Janakiraman (2003 são, parcialmente, aplicáveis ao Brasil.The study tests and confirms the hypothesis that costs of Brazilian firms are sticky, i.e. that costs increase with more intensity when revenues increase than in the opposite direction, as shown by recent empirical evidence involving American firms. As opposed to this evidence, however, the sticky behavior does not seem to decrease when periods over one year are considered. The possibility of a partial reversion of the asymmetry when lagged periods are tested is confirmed in the study. The adopted methodology involves different types of panel data regressions. The paper intends to contribute to a better understanding of Brazilian firms' cost behavior related to changes in the firms' activity level, which is a relevant theme for business administration, accountants and

  19. Topographic Lidar Survey of the Chandeleur Islands, Louisiana, February 6, 2012 -- Bare Earth DEMs

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — A topographic Lidar survey was conducted on February 6, 2012, over the Chandeleur Islands, Louisiana. The data were collected at a nominal pulse space of 0.5-meter...

  20. Topographic Lidar Survey of the Chandeleur Islands, Louisiana, February 6, 2012 -- Bare Earth DEMs

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — A topographic Lidar survey was conducted on February 6, 2012, over the Chandeleur Islands, Louisiana. The data were collected at a nominal pulse space of 0.5-meter...

  1. Um estudo comparativo da freqüência de verbalização empática entre psicoterapeutas de diferentes abordagens teóricas

    OpenAIRE

    Falcone,Eliane Mary de Oliveira; Gil,Débora Barbosa; Ferreira,Maria Cristina

    2007-01-01

    O estudo comparou a freqüência de verbalização empática entre dezesseis terapeutas distribuídos em quatro grupos de diferentes orientações: terapia centrada na pessoa, Gestalt-terapia, terapia cognitivo-comportamental e lacaniana. Cada terapeuta entrevistou a mesma cliente que apresentou a mesma queixa e o conteúdo das entrevistas foi avaliado por três juízes independentes e pela cliente. De acordo com a avaliação dos juízes, o grupo de terapia centrada na pessoa revelou freqüência de verbali...

  2. La teoría fundamentada en el estudio empírico de las representaciones sociales: un caso sobre el rol orientador del docente

    OpenAIRE

    María Campo-Redondo; Catalina Labarca Reverol

    2009-01-01

    Este artículo tiene como objetivo, explicar y demostrar la aplicación de la teoría fundamentada al estudio de las representaciones sociales. Se considera adecuada la postura estructural para este estudio, ya que es mediante el uso del núcleo figurativo que se puede hacer una integración de esta teoría con la teoría fundamentada. Se presenta una ejemplificación empírica de la utilización y aplicación de la teoría fundamentada en el estudio de las representaciones sociales del rol orientador de...

  3. El conductismo en la ciencia política: descifrando un concepto poco maleable en los horizontes de la investigación empírica

    Directory of Open Access Journals (Sweden)

    John Fredy Bedoya Marulanda

    2015-01-01

    Full Text Available Este artículo tiene como objetivo revivir el conductismo como una forma derealizar investigación empírica en la ciencia política, haciendo el llamado a lacientificidad de la disciplina con un objeto de estudio específico: elcomportamiento político de los individuos. Desde allí se presenta como sepuede definir el conductismo, sus cánones metodológicos y una aproximación acómo debe entenderse el comportamiento político.

  4. La dirección soft y hard de recursos humanos desde los principios éticos: una contrastación empírica

    OpenAIRE

    Ting Ding, Jyh-Ming

    2007-01-01

    [ES] Teniendo en cuenta la importancia de una gestión ética de los recursos humanos, el objetivo del presente trabajo consiste en determinar si las empresas aplican diferentes modelos de gestión. Para ello, se ha tratado de comprobar si las empresas aplican una dirección de recursos humanos (DRRHH) soft o hard y sobre la base de qué perspectivas éticas lo hacen, tratando de contrastar los cuatro modelos de DRRHH propuestos por Greenwood (2004). El estudio empírico realizado a una muestra de 1...

  5. La seducción en "Los empeños de una casa" o cómo subvertir los espacios del deseo.

    Directory of Open Access Journals (Sweden)

    Rubén Domínguez Quintana

    2010-01-01

    Full Text Available En este trabajo abordaremos el texto dramático de Sor Juana Inés de la Cruz cuestionando las estructuras patriarcales que distribuyen espacialmente a los sujetos dentro y fuera de la escena. Mediante el estudio de las maniobras seductoras que la performance del personaje Castaño realiza al vestirse de mujer, podremos comprobar cómo Los empeños de una casa desafía los mecanismos del deseo genérico-sexual que dejarán evidencia el orden patriarcal, al tiempo que subvierten los espacios asignados a hombres y mujeres en la obra.

  6. El Síndrome de "Burnout" o el desgaste profesional (II): Estudio empírico de los profesionales gallegos del área de Salud Mental.

    OpenAIRE

    E Álvarez Gallego; Luis Fernández Ríos

    1991-01-01

    Este trabajo supone una aproximación empírica al síndrome de "Burnout". Para ello se ha tomado un grupo de profesionales gallegos del área de Salud Mental. Los instrumentos utilizados para operativizar las variables han sido, el Maslach Burnout Inventory (M.B.I.) de Maslach and Jackson para la medición del "desgaste profesional" y la Escala de Clima Social en el Trabajo (W.E.S.) de R.H. Moos. Los resultados muestran la presencia de un considerable cansancio emocional como resultado del contex...

  7. Estudio conformacional, utilizando un potencial átomo-átomo empírico, de análogos de Taurina

    OpenAIRE

    Ana M. Rodríguez; Ciuffo,Gladys M.; Estrada, Mario R.; Jáuregui, Esteban A.

    1989-01-01

    Taurina es un ß-aminoácido reconocido como neuromodulador. Se realizó un estudio conformacional sobre una serie de análogos estructuralmente relacionados a taurina: L-cisteinsulfínico, homotaurina, ß-alanina, ß-alanina y L-cisteina. Todos ellos se estudiaron en la forma zwitter-iónica, por ser la especie preponderante a pH fisiológico. Para realizar el análisis conformacional se empleó un potencial átomo-átomo empírico. En todos los casos estudiados se obtiene un equilibrio conformacional ent...

  8. La restricción intertemporal del presupuesto. Una evaluación empírica para el Gobierno Nacional Central de Colombia, 1950-2010

    Directory of Open Access Journals (Sweden)

    Hernando Chaves Álvaro

    2003-12-01

    Full Text Available En este documento se analiza la sostenibilidad fiscal del Gobierno Nacional Central en Colombia utilizando el enfoque de la Restricción Intertemporal de Presupuesto. Los resultados empíricos revelan que la estrategia fiscal actual es sostenible. No obstante, se vislumbran problemas de insolvencia en el largo plazo, lo que implica generar un mayor superávit primario en comparación con el actualmente programado. Lo anterior, se sustenta en los valores estimados de los indicadores de sostenibilidad fiscal.

  9. Extramedullary (EMP) relapse in unusual locations in multiple myeloma: Is there an association with precedent thalidomide administration and a correlation of special biological features with treatment and outcome?

    Science.gov (United States)

    Katodritou, E; Gastari, V; Verrou, E; Hadjiaggelidou, C; Varthaliti, M; Georgiadou, S; Laschos, K; Xirou, P; Yiannaki, E; Constantinou, N; Markala, D; Zervas, K

    2009-08-01

    Extramedullary relapse constitutes an uncommon manifestation of multiple myeloma (MM), characterized by highly malignant histology, special biological features, resistance to treatment and poor outcome. Its incidence has been increased during the last years, probably due to the introduction of novel strategies in the management of MM, including intensified treatment and immunomodulatory drugs. Here we report nine cases of extramedullary relapse of MM, presented in unusual locations, seven of which had previously been treated with thalidomide-containing regimens (TCR). Our aim was to explore the morphological, immunophenotypical, molecular and laboratory characteristics accompanying EMP-relapse and seek possible correlations with treatment and clinical outcome.

  10. La especialidad del Derecho penal de adolescentes: Fundamentos empíricos y normativos, y consecuencias para una aplicación diferenciada del Derecho penal sustantivo

    OpenAIRE

    Couso,Jaime

    2012-01-01

    A la luz de los conocimientos empíricos aportados por la psicología del desarrollo y la criminología, y de los principios de derecho internacional que exigen dar un tratamiento jurídico especial a los adolescentes en materia penal, distinto del que reciben los mayores de edad, el artículo identifica una serie de estándares de juzgamiento diferenciado que deberían ser tenidos en cuenta en la aplicación del derecho penal sustantivo por parte de los tribunales. Para determinar con mayor precisió...

  11. Funcionamiento cognitivo en la vejez: desde el modelo bidimensional y desde el modelo de pensamiento crítico : Un estudio empírico

    OpenAIRE

    Maccarone, Silvina; Monchietti, Alicia

    2009-01-01

    Este trabajo presenta resultados de un proyecto de investigación realizado durante el año 2008 en el marco de una Beca de investigación otorgada por la Universidad Nacional de Mar del Plata. El mismo forma parte de los proyectos que desarrolla el Grupo de Investigación “Temas de Psicología del Desarrollo” orientados a caracterizar la cognición y el pensamiento en la vejez. Aquí se explora el funcionamiento cognitivo en el envejecimiento normal, desde dos modelos teórico-empíricos: bidimension...

  12. El conductismo en la ciencia política: descifrando un concepto poco maleable en los horizontes de la investigación empírica

    OpenAIRE

    John Fredy Bedoya Marulanda

    2015-01-01

    Este artículo tiene como objetivo revivir el conductismo como una forma derealizar investigación empírica en la ciencia política, haciendo el llamado a lacientificidad de la disciplina con un objeto de estudio específico: elcomportamiento político de los individuos. Desde allí se presenta como sepuede definir el conductismo, sus cánones metodológicos y una aproximación acómo debe entenderse el comportamiento político.

  13. Crecimiento económico en Colombia: una aproximación empírica fundamentada en la perspectiva capital humano (1960-2009)

    OpenAIRE

    Maria Esperanza Cuenca Coral; Ignacio Penagos Montoya

    2014-01-01

    El objetivo de este artículo es especificar un modelo empírico basado en los argumentos teóricos, que cuantifique la influencia del capital humano, medido a través de un conjunto de variables que reflejan el comportamiento de la salud y la educación, sobre el resultado del crecimiento económico observado para Colombia, entre los años 1960 y 2009. Realiza un recorrido por la literatura referente al crecimiento económico y el capital humano, representado por la salud y la educación, de tal mane...

  14. El conductismo en la ciencia política: descifrando un concepto poco maleable en los horizontes de la investigación empírica

    OpenAIRE

    John Fredy Bedoya Marulanda

    2015-01-01

    Este artículo tiene como objetivo revivir el conductismo como una forma derealizar investigación empírica en la ciencia política, haciendo el llamado a lacientificidad de la disciplina con un objeto de estudio específico: elcomportamiento político de los individuos. Desde allí se presenta como sepuede definir el conductismo, sus cánones metodológicos y una aproximación acómo debe entenderse el comportamiento político.

  15. Um estudo comparativo da freqüência de verbalização empática entre psicoterapeutas de diferentes abordagens teóricas

    OpenAIRE

    Falcone,Eliane Mary de Oliveira; Gil,Débora Barbosa; Ferreira, Maria Cristina

    2007-01-01

    O estudo comparou a freqüência de verbalização empática entre dezesseis terapeutas distribuídos em quatro grupos de diferentes orientações: terapia centrada na pessoa, Gestalt-terapia, terapia cognitivo-comportamental e lacaniana. Cada terapeuta entrevistou a mesma cliente que apresentou a mesma queixa e o conteúdo das entrevistas foi avaliado por três juízes independentes e pela cliente. De acordo com a avaliação dos juízes, o grupo de terapia centrada na pessoa revelou freqüência de verbali...

  16. Verificación empírica del modelo de precios rígidos en la economía colombiana, 1995:I–2006:I

    Directory of Open Access Journals (Sweden)

    Andrés Ramírez Hassan

    2007-10-01

    Full Text Available En este artículo se contrasta empíricamente la validez del enfoque monetario de precios rígidos para la determinación de la tasa de cambio en la economía colombiana para el período 1995-2006 a través de la técnica econométrica de cointegración. Se encuentra que las variables relevantes en el modelo forman una relación estable de largo plazo, y que los signos de las elasticidades estimadas son conformes a lo planteado por la teoría.

  17. Identificación con los personajes y disfrute ante largometrajes de ficción. Una investigación empírica

    OpenAIRE

    Igartua, J.J. (Juan José); Múñiz, C. (Carlos)

    2008-01-01

    La investigación sobre entretenimiento mediático ha teorizado que uno de los principales factores explicativos del disfrute de los formatos narrativos es la identificación con los personajes. Sin embargo es escasa la investigación empírica al respecto. Se presentan los resultados de una investigación cuantitativa en la que se entrevistó a 300 sujetos, a la salida de las salas de cine en las que se exhibían los largometrajes Mar adentro, El lobo y Bridget Jones: sobreviviré. Los resultados ind...

  18. Responsabilidad Social Corporativa de la Empresas de Distribución Comercial Españolas. Evidencias Empíricas

    OpenAIRE

    Díaz Heredia, Isabel

    2013-01-01

    En este Trabajo Fin de Máster se analiza la Responsabilidad Social Corporativa de las grandes empresas de distribución comercial en España. En él se trata el desarrollo teórico de la RSC, el sector de la distribución comercial y, por último, se realiza un estudio empírico para el análisis del grado de RSC on-line en las grandes empresas de distribución comercial.

  19. Estimación de escalas de equivalencia a partir de las preferencias de consumo reveladas. Un aporte empírico para los hogares de CABA

    OpenAIRE

    Echeverría, Lucía

    2013-01-01

    El objetivo de la presente investigación consiste en estimar escalas de equivalencia asociadas a un nivel de subsistencia (mínimo nivel de bienestar) para los tipos de hogares más representativos de la Ciudad Autónoma de Buenos Aires. Para ello, se estima un sistema completo de demanda cuadrático (QES) empleando los datos de la Encuesta Nacional de Gastos de los Hogares correspondiente al período 2004/2005. Adicionalmente, se comparan las escalas obtenidas empíricamente a partir preferencias ...

  20. Análisis empírico descriptivo de empresas bajo el régimen de oferta pública

    OpenAIRE

    Granieri, Constanza; Juarros, María Laura; Flores, N. Magalí

    2013-01-01

    El presente trabajo tiene como objetivo presentar las características de aquellas empresas que están bajo régimen directo de la Comisión Nacional de Valores (CNV) y sus subsidiarias, en función de ciertas variables contempladas en nuestra investigación empírica. Se encuentra enmarcado en el proyecto de investigación “Análisis de los marcos regulatorios en la información contable, los sectores económicos y los modelos decisorios”, en el cual se ha desarrollado una base de datos utilizada co...

  1. COMPUTER BASED HEART PULSES MEASUREMENT

    Directory of Open Access Journals (Sweden)

    Ali N. Hamoodi

    2013-05-01

    Full Text Available In this work the measurement and displays of blood oxygen saturation and pulse rate are investigated practically using computer.The analysis involves the variation in blood oxygen saturation ratio and pulse rate. The results obtained are compared with kontron pulse oximeter 7840 device. The value obtained for the same person pulse rate is approximately equal to that obtained by the konton pulse oximeter 7840 device. The sensor used in this work is the finger clip.The advantages of using computer over kontron pulse oximeter 7840 device is that the data of the patient can be saved in the computer for many years and also it can be display at any time so that the doctor get file contains all data for each patient. 

  2. Angular momentum of sound pulses.

    Science.gov (United States)

    Lekner, John

    2006-07-05

    Three-dimensionally localized acoustic pulses in an isotropic fluid medium necessarily have transverse components of momentum density. Those with an azimuthal component of momentum density can carry angular momentum. The component of total pulse angular momentum along the direction of the total momentum is an invariant (constant in time and independent of choice of origin). The pulse energy, momentum and angular momentum are evaluated analytically for a family of localized solutions of the wave equation. In the limit where the pulses have many oscillations within their spatial extent ([Formula: see text], where k is the wavenumber and a determines the size of a pulse), the energy, momentum and angular momentum are consistent with a multiphonon representation of the pulse, each phonon having energy [Formula: see text], momentum [Formula: see text] and angular momentum [Formula: see text] (with integer m).

  3. The Brightest Pulses in the Universe

    Science.gov (United States)

    McLaughlin, Maura

    2016-06-01

    Over the past decade, the transient radio sky has been probed with unprecedented depth and time resolution. This has resulted in the recognition of a new class of short-duration radio transients called Fast Radio Bursts (FRBs). FRBs have pulse widths of 1-20 milliseconds and dispersion measures much higher than predicted from Galactic electron density models, indicating a likely extragalactic origin. Many models have been put forward for the origin of FRBs. Some of these models involve cataclysmic events such as a neutron star merger and others energetic but repeatable emission such as giant pulses from an extragalactic radio pulsar. Over the past year, several discoveries have provided tantalizing evidence for the origin of these bursts. These include measurements of scintillation and polarization, a possible detection of an associated host galaxy, and the first detection of repeated bursts from an FRB. At the same time, interferometric surveys are soon expected to result in the first detections of highly localized FRBs, which may lead to definitive associations with known sources. In this talk, I will review the history of FRB detection and the properties of the roughly 20 known FRBs. I will then review the evidence for the extragalactic origin of these bursts, and discuss possible sources. Finally, I will look to the future of this emerging field, describe the capabilities of upcoming surveys and instruments, and how FRBs could be used as astrophysical and cosmological probes.

  4. Bipolar pulse forming line

    Science.gov (United States)

    Rhodes, Mark A.

    2008-10-21

    A bipolar pulse forming transmission line module for linear induction accelerators having first, second, third, fourth, and fifth planar conductors which form an interleaved stack with dielectric layers between the conductors. Each conductor has a first end, and a second end adjacent an acceleration axis. The first and second planar conductors are connected to each other at the second ends, the fourth and fifth planar conductors are connected to each other at the second ends, and the first and fifth planar conductors are connected to each other at the first ends via a shorting plate adjacent the first ends. The third planar conductor is electrically connectable to a high voltage source, and an internal switch functions to short a high voltage from the first end of the third planar conductor to the first end of the fourth planar conductor to produce a bipolar pulse at the acceleration axis with a zero net time integral. Improved access to the switch is enabled by an aperture through the shorting plate and the proximity of the aperture to the switch.

  5. Heat driven pulse pump

    Science.gov (United States)

    Benner, Steve M (Inventor); Martins, Mario S. (Inventor)

    2000-01-01

    A heat driven pulse pump includes a chamber having an inlet port, an outlet port, two check valves, a wick, and a heater. The chamber may include a plurality of grooves inside wall of the chamber. When heated within the chamber, a liquid to be pumped vaporizes and creates pressure head that expels the liquid through the outlet port. As liquid separating means, the wick, disposed within the chamber, is to allow, when saturated with the liquid, the passage of only liquid being forced by the pressure head in the chamber, preventing the vapor from exiting from the chamber through the outlet port. A plurality of grooves along the inside surface wall of the chamber can sustain the liquid, which is amount enough to produce vapor for the pressure head in the chamber. With only two simple moving parts, two check valves, the heat driven pulse pump can effectively function over the long lifetimes without maintenance or replacement. For continuous flow of the liquid to be pumped a plurality of pumps may be connected in parallel.

  6. Assembly delay line pulse generators

    CERN Document Server

    1971-01-01

    Assembly of six of the ten delay line pulse generators that will power the ten kicker magnet modules. One modulator part contains two pulse generators. Capacitors, inductances, and voltage dividers are in the oil tank on the left. Triggered high-pressure spark gap switches are on the platforms on the right. High voltage pulse cables to the kicker magnet emerge under the spark gaps. In the centre background are the assembled master gaps.

  7. Multi pulse control of entanglement

    CERN Document Server

    Uchiyama, C; Uchiyama, Chikako; Aihara, Masaki

    2004-01-01

    We study the effectiveness of multi pulse control to suppress the degradation of entanglement. Based on a linearly interacting spin-boson model, we show that the multi pulse application recovers the decay of concurrence when an entangled pair of spins interacts with a reservoir that has the non-Markovian nature. We present the effectiveness of multi pulse control for both the common bath case and the individual bath case.

  8. "Suntelligence" Survey

    Science.gov (United States)

    ... to the American Academy of Dermatology's "Suntelligence" sun-smart survey. Please answer the following questions to measure ... be able to view a ranking of major cities suntelligence based on residents' responses to this survey. ...

  9. Analysis of Pulse Modulated Control Systems (Ⅲ) Stability of Systems with Pulse Frequency Modulation and Systems with Combined Pulse Frequency and Pulse Width Modulation

    OpenAIRE

    OI,Shigemitsu

    1993-01-01

    Sufficient conditions for finite pulse stability of interconnected systems with combined pulse frequency and pulse width modulation are developed in this paper using a direct method. The stability criteria established provide upper bounds on the number of pulses emitted by each modulator. The results are also applicable to those systems which contain a finite number of pulse frequency modulators and a finite number of combined pulse frequency and pulse width modulators

  10. Population inversion by chirped pulses

    Energy Technology Data Exchange (ETDEWEB)

    Lu Tianshi [Department of Mathematics and Statistics, Wichita State University, Wichita, Kansas 67260-0033 (United States)

    2011-09-15

    In this paper, we analyze the condition for complete population inversion by a chirped pulse over a finite duration. The nonadiabatic transition probability is mapped in the two-dimensional parameter space of coupling strength and detuning amplitude. Asymptotic forms of the probability are derived by the interference of nonadiabatic transitions for sinusoidal and triangular pulses. The qualitative difference between the maps for the two types of pulses is accounted for. The map is used for the design of stable inversion pulses under specific accuracy thresholds.

  11. Double pulse laser wakefield accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Changbum [Department of Physics, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of)], E-mail: chbkim@postech.ac.kr; Kim, Jin-Cheol B. [Department of Physics, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Kim, Kukhee [National Fusion Reserch Center, Daejeon 305-333 (Korea, Republic of); Ko, In Soo [Department of Physics, Pohang University of Science and Technology, Pohang 790-784 (Korea, Republic of); Suk, Hyyong [Center for Advanced Accelerators, Korea Electrotechnology Research Institute, Changwon 641-120 (Korea, Republic of)

    2007-10-22

    Two-dimensional simulation studies are performed for modified laser wakefield acceleration. After one laser pulse, another identical laser pulse is sent to the plasma to amplify the wake wave resonantly. The simulation results show that the number of injected electrons is bigger than that of the single pulse case and the beam energy is higher as well. In addition, increase of the transverse amplitude is noticed in the wake wave after the second laser pulse. This shows that the transverse motion of the wake wave enhances the wave breaking for strong injection and acceleration of electron beams.

  12. Pulse oximetry in severe anaemia

    DEFF Research Database (Denmark)

    Ramsing, T; Rosenberg, J

    1992-01-01

    Measurement of arterial oxygen saturation by pulse oximetry was performed in two patients with acute and chronic anaemia (haemoglobin concentrations: 2.9 mmol/l (4.7 g/dl) and 1.9 mmol/l (3.0 g/dl), respectively) using a Radiometer OXI and a Nellcor N-200 pulse oximeter. The two oximeters read...... alternating different values in the two patients. In conclusion, pulse oximeters are able to give a value for oxygen saturation even at extreme anaemia, and when a high value is given, it possibly reflects arterial oxygen saturation. The value of pulse oximetry in severe anaemia is discussed....

  13. A semi-automated multiplex high-throughput assay for measuring IgG antibodies against Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) domains in small volumes of plasma

    DEFF Research Database (Denmark)

    Cham, Gerald K K; Kurtis, Jonathan; Lusingu, John;

    2008-01-01

    BACKGROUND: The level of antibodies against PfEMP1 is routinely quantified by the conventional microtitre enzyme-linked immunosorbent assay (ELISA). However, ELISA only measures one analyte at a time and requires a relatively large plasma volume if the complete antibody profile of the sample...... of twenty nine PfEMP1 domains were PCR amplified from 3D7 genomic DNA, expressed in the Baculovirus system and purified by metal-affinity chromatography. The antibody reactivity level to the recombinant PfEMP1 proteins in human hyper-immune plasma was measured by ELISA. In parallel, these recombinant PfEMP1......-based assay was sensitive, accurate and reproducible. Four recombinant PfEMP1 proteins C17, D5, D9 and D12, selected on the basis that they showed a spread of median fluorescent intensity (MFI) values from low to high when analysed by the bead-based assay were analysed by ELISA and the results from both...

  14. Survey Says

    Science.gov (United States)

    McCarthy, Susan K.

    2005-01-01

    Survey Says is a lesson plan designed to teach college students how to access Internet resources for valid data related to the sexual health of young people. Discussion questions based on the most recent available data from two national surveys, the Youth Risk Behavior Surveillance-United States, 2003 (CDC, 2004) and the National Survey of…

  15. Theoretical Studies of the Output Pulse with Variation of the Pumping Pulse for RF Excited CO2 Pulsed Waveguide Laser

    Institute of Scientific and Technical Information of China (English)

    A Rauf; ZHOU Wei; XIN Jian-guo

    2006-01-01

    The behavior of a RF-excited waveguide CO2 laser in the pulse regime is studied theoretically. The output pulse evolution is studied by applying three types of pulses namely the square, sine and the triangular ones as the excitation pulses. The frequency dependence behavior of the output pulse is also presented.

  16. Pulse-shaping strategies in short-pulse fiber amplifiers

    Energy Technology Data Exchange (ETDEWEB)

    Schimpf, Damian Nikolaus

    2010-02-09

    Ultrashort pulse lasers are an important tool in scientific and industrial applications. However, many applications are demanding higher average powers from these ultrashort pulse sources. This can be achieved by combining direct diode pumping with novel gain media designs. In particular, ultrashort pulse fiber lasers are now delivering average powers in the kW range. However, the design of fiber lasers, producing pulses with high peak-powers, is challenging due to the impact of nonlinear effects. To significantly reduce these detrimental effects in ultrashort pulse fiber amplifers, the combination of chirped pulse amplification (CPA) and large mode area fibers is employed. Using these methods, the pulse energy of fiber lasers has been steadily increasing for the past few years. Recently, a fiber-based CPA-system has been demonstrated which produces pulse energies of around 1 mJ. However, both the stretching and the enlargement of the mode area are limited, and therefore, the impact of nonlinearity is still noticed in systems employing such devices. The aim of this thesis is the analysis of CPA-systems operated beyond the conventional nonlinear limit, which corresponds to accumulated nonlinear phase-shifts around 1 rad. This includes a detailed discussion of the influence of the nonlinear effect self-phase modulation on the output pulse of CPA-systems. An analytical model is presented. Emphasis is placed on the design of novel concepts to control the impact of self-phase modulation. Pulse-shaping is regarded as a powerful tool to accomplish this goal. Novel methods to control the impact of SPM are experimentally demonstrated. The design of these concepts is based on the theoretical findings. Both amplitude- and phase-shaping are studied. Model-based phase-shaping is implemented in a state-of-the-art fiber CPA-system. The influence of the polarization state is also highlighted. Additionally, existing techniques and recent advances are put into context. (orig.)

  17. The effect of electromagnetic pulse on neuronal ultrastructure and the space learning and memory ability in rats%电磁脉冲辐射致大鼠皮层神经元超微结构损伤效应及对空间学习记忆能力的影响

    Institute of Scientific and Technical Information of China (English)

    张进; 邓斌; 徐浩; 李俊钢; 邓克强; 刘太阳生; 徐礼鲜

    2013-01-01

    目的:电磁脉冲辐射(electromagnetic pulse,EMP)可以引起中枢神经系统(CNS)损伤和神经行为学的改变.因此,研究EMP对CNS短期的生物学效应具有重要意义.方法:本文通过电子显微镜技术和Morris水迷宫技术,研究了场强为400 kV/m,脉冲为200次的EMP辐射后短时间内对大鼠皮层神经元超微结构及空间学习记忆能力的影响.结果:辐照射后6h的大鼠皮层神经元超微结构显示,神经元胞核内异染色质增多;核膜有不同程度凹陷、破损及皱缩.胞质内有明显的线粒体肿胀;胞内粗面内质网呈囊性变、脱颗粒.EMP辐射后24 h时,部分神经元出现染色质浓集、边移,甚至细胞核明显皱缩而失去结构,类似凋亡细胞特点,并有凋亡小体出现.Morris水迷宫结果显示,与正常对照组相比,EMP损伤后,大鼠逃避潜伏期明显延长(P<0.05);动物在平台象限停留时间明显缩短(P<0.01).结论:400 kV/m的EMP可引起大脑皮层神经元超微结构发生损伤,且导致实验动物空间学习记忆能力的下降.%Objective:Electromagnetic pulse (EMP) can cause central nervous system (CNS) damage and neurobehavioral disorders.To study the biological effects of EMP on CNS may have important applied value.Here we reported that the biological effects of EMP (400 kV/m for 200 pulses) on neuronal ultrastructure and the space learning and memory ability in rats.Methods:The electron microscopic technology and Morris water maze was used to observe the effect of EMP on cerebral cortex neurons.Results:Electron microscope results showed the ultrastructure of rat cortical neurons in EMP group 6 h after radiation changed markedly,characterized with nuclear membrane folds,collapses,blurred boundaries,nuclear condensation.It also showed obvious swelling of mitochondria in the cytoplasm was as spherical.Moreover,at 24 h after EMP radiation,some cellular cytoplasm concentration happened as electron density increased

  18. Pulsed plasma arc cladding

    Institute of Scientific and Technical Information of China (English)

    龙; 白钢; 李振民; 张赋升; 杨思乾

    2004-01-01

    A prototype of Pulsed Plasma Arc Cladding system was developed, in which single power source supplies both transferred plasma arc (TPA) and non-transferred plasma arc (N-TPA). Both plasmas work in turn in a high frequency controlled by an IGBT connecting nozzle and workpiece. The working frequency of IGBT ranges from 50 ~ 7000Hz, in which the plasmas can work in turn smoothly. Higher than 500 Hz of working frequency is suggested for promotion of cladding quality and protection of IGBT. Drag phenomenon of TPA intensifies as the frequency goes up, which tends to increase the current proportion of TPA and suppress N-TPA. The occupation ratio of IGBT can be regulated from 5% ~ 95%, which balances the power supplies of both plasmas. An occupation ratio higher than 50% gives adequate proportion of arc current for N-TPA to preheat powder.

  19. Nanofabrication with Pulsed Lasers

    Directory of Open Access Journals (Sweden)

    Kabashin AV

    2010-01-01

    Full Text Available Abstract An overview of pulsed laser-assisted methods for nanofabrication, which are currently developed in our Institute (LP3, is presented. The methods compass a variety of possibilities for material nanostructuring offered by laser–matter interactions and imply either the nanostructuring of the laser-illuminated surface itself, as in cases of direct laser ablation or laser plasma-assisted treatment of semiconductors to form light-absorbing and light-emitting nano-architectures, as well as periodic nanoarrays, or laser-assisted production of nanoclusters and their controlled growth in gaseous or liquid medium to form nanostructured films or colloidal nanoparticles. Nanomaterials synthesized by laser-assisted methods have a variety of unique properties, not reproducible by any other route, and are of importance for photovoltaics, optoelectronics, biological sensing, imaging and therapeutics.

  20. Nanosecond Pulse Technique

    Science.gov (United States)

    1989-03-17

    tunnel diodes, to ferrites, etc.) and to the need for the review of the methods of formation and converting the pulses, to a considerable degree...4n3l) 0 1 + 4n 21)2 + (4n2l) (.84) _ 4 nf tl 5 (I - 4n12/) 2 - (4nil)’ (1.85) " ( - 2o) l - 4’n2% 2 I3 (I + 4n =2/)2 + ( 41a2 )’ -arg + 4ni,21. + j4na,tJ...recirculator is borrowed from the article of Yu. I. Neymark, Yu. K. Maklakov and L. P. Yelkins [105]. ENDFOOTNOTE. DOC = 88076720 PAGE d a) t l I t S6) t�t

  1. Nanofabrication with pulsed lasers.

    Science.gov (United States)

    Kabashin, Av; Delaporte, Ph; Pereira, A; Grojo, D; Torres, R; Sarnet, Th; Sentis, M

    2010-02-24

    An overview of pulsed laser-assisted methods for nanofabrication, which are currently developed in our Institute (LP3), is presented. The methods compass a variety of possibilities for material nanostructuring offered by laser-matter interactions and imply either the nanostructuring of the laser-illuminated surface itself, as in cases of direct laser ablation or laser plasma-assisted treatment of semiconductors to form light-absorbing and light-emitting nano-architectures, as well as periodic nanoarrays, or laser-assisted production of nanoclusters and their controlled growth in gaseous or liquid medium to form nanostructured films or colloidal nanoparticles. Nanomaterials synthesized by laser-assisted methods have a variety of unique properties, not reproducible by any other route, and are of importance for photovoltaics, optoelectronics, biological sensing, imaging and therapeutics.

  2. Pulsed plasma electron sourcesa)

    Science.gov (United States)

    Krasik, Ya. E.; Yarmolich, D.; Gleizer, J. Z.; Vekselman, V.; Hadas, Y.; Gurovich, V. Tz.; Felsteiner, J.

    2009-05-01

    There is a continuous interest in research of electron sources which can be used for generation of uniform electron beams produced at E ≤105 V/cm and duration ≤10-5 s. In this review, several types of plasma electron sources will be considered, namely, passive (metal ceramic, velvet and carbon fiber with and without CsI coating, and multicapillary and multislot cathodes) and active (ferroelectric and hollow anodes) plasma sources. The operation of passive sources is governed by the formation of flashover plasma whose parameters depend on the amplitude and rise time of the accelerating electric field. In the case of ferroelectric and hollow-anode plasma sources the plasma parameters are controlled by the driving pulse and discharge current, respectively. Using different time- and space-resolved electrical, optical, spectroscopical, Thomson scattering and x-ray diagnostics, the parameters of the plasma and generated electron beam were characterized.

  3. Micro pulse lidar

    Science.gov (United States)

    Spinhirne, James D.

    1993-01-01

    An eye safe, compact, solid state lidar for profiling atmospheric cloud and aerosol scattering has been demonstrated. The transmitter of the micropulse lidar is a diode pumped micro-J pulse energy, high repetition rate Nd:YLF laser. Eye safety is obtained through beam expansion. The receiver employs a photon counting solid state Geiger mode avalanche photodiode detector. Data acquisition is by a single card multichannel scaler. Daytime background induced quantum noise is controlled by a narrow receiver field-of-view and a narrow bandwidth temperature controlled interference filter. Dynamic range of the signal is limited by optical geometric signal compression. Signal simulations and initial atmospheric measurements indicate that systems built on the micropulse lidar concept are capable of detecting and profiling all significant cloud and aerosol scattering through the troposphere and into the stratosphere. The intended applications are scientific studies and environmental monitoring which require full time, unattended measurements of the cloud and aerosol height structure.

  4. Capacitor discharge pulse analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Michael Sean; Griffiths, Stewart K.; Tanner, Danelle Mary

    2013-08-01

    Capacitors used in firing sets and other high discharge current applications are discharge tested to verify performance of the capacitor against the application requirements. Parameters such as capacitance, inductance, rise time, pulse width, peak current and current reversal must be verified to ensure that the capacitor will meet the application needs. This report summarizes an analysis performed on the discharge current data to extract these parameters by fitting a second-order system model to the discharge data and using this fit to determine the resulting performance metrics. Details of the theory and implementation are presented. Using the best-fit second-order system model to extract these metrics results in less sensitivity to noise in the measured data and allows for direct extraction of the total series resistance, inductance, and capacitance.

  5. ¿Son los mercados de internet más eficientes?: Resumen de las últimas evidencias empíricas

    Directory of Open Access Journals (Sweden)

    Francesc Sole

    2004-01-01

    Full Text Available Uno de los fenómenos asociados a la Nueva Economía es el E-Business, es decir, la realización de negocios a través de Internet y la consecuente aparición de marketplaces o mercados electrónicos que ‘conviven’ con los mercados tradicionales. Es oportuno plantear elestado del arte de los estudios empíricos centrados en comparar cuan eficiente es cada tipo de mercado. En términos generales, se trata de ver si los actuales estudios han confirmado o no, la hipótesis intuitiva de que los mercados electrónicos son más eficientes, y en consecuencia, más próximos al mercado de competencia perfecta que describe la teoría económica clásica. Este paper centrará su interés en resumir los avances empíricos en el estudio de variables relacionadas con la eficiencia del mercado, como son el precio, su variabilidad, su dispersión y su elasticidad.

  6. Contramedidas em segurança da informação e vulnerabilidade cibernética: evidência empírica de empresas brasileiras

    Directory of Open Access Journals (Sweden)

    Igor Siqueira Cortez

    2013-12-01

    Full Text Available Recentemente, uma série de ataques cibernéticos a empresas e governos no Brasil e no exterior tornou público o potencial impacto econômico desse tipo de atividade, do ponto de vista tanto privado quanto público. Existe extensa literatura econômica - teórica e empírica - que avalia os incentivos para que as empresas adotem ou não medidas de segurança da informação. No presente estudo foi desenvolvida uma avaliação empírica desse fenômeno no Brasil. Modelos logit e probit ordenado foram desenvolvidos como forma de avaliar os efeitos sobre a probabilidade de ocorrência de problemas de segurança da informação, levando-se em conta as características das firmas, inclusive as medidas de segurança de informação. Os resultados apontam para uma relação positiva entre as medidas de segurança da informação e a probabilidade de identificar a ocorrência de problemas cibernéticos, sugerindo que a sofisticação dessas medidas de proteção aumenta a probabilidade de identificação dos problemas.

  7. Relationships between the use of Embden Meyerhof pathway (EMP) or Phosphoketolase pathway (PKP) and lactate production capabilities of diverse Lactobacillus reuteri strains.

    Science.gov (United States)

    Burgé, Grégoire; Saulou-Bérion, Claire; Moussa, Marwen; Allais, Florent; Athes, Violaine; Spinnler, Henry-Eric

    2015-10-01

    The aims of this study is to compare the growth and glucose metabolism of three Lactobacillus reuteri strains (i.e. DSM 20016, DSM 17938, and ATCC 53608) which are lactic acid bacteria of interest used for diverse applications such as probiotics implying the production of biomass, or for the production of valuable chemicals (3-hydroxypropionaldehyde, 3-hydroxypropionic acid, 1,3-propanediol). However, the physiological diversity inside the species, even for basic metabolisms, like its capacity of acidification or glucose metabolism, has not been studied yet. In the present work, the growth and metabolism of three strains representative of the species diversity have been studied in batch mode. The strains were compared through characterization of growth kinetics and evaluation of acidification kinetics, substrate consumption and product formation. The results showed significant differences between the three strains which may be explained, at least in part, by variations in the distribution of carbon source between two glycolytic pathways during the bacterial growth: the phosphoketolase or heterolactic pathway (PKP) and the Embden-Meyerhof pathway (EMP). It was also shown that, in the context of obtaining a large amount of biomass, DSM 20016 and DSM 17938 strains were the most effective in terms of growth kinetics. The DSM 17938 strain, which shows the more significant metabolic shift from EMP to PKP when the pH decreases, is more effective for lactate production.

  8. Ayudas públicas a la innovación: una evidencia empírica de la PYME industrial del sureste mexicano

    Directory of Open Access Journals (Sweden)

    Gabriel Góngora-Biachi

    2009-08-01

    Full Text Available Este trabajo tiene como propósito estudiar la existencia de tres tipos de sesgo en el proceso de solicitud y concesión de ayudas a la innovación a la PYME industrial en México (sesgo de motivación, sesgo de selección administrativa y sesgo de información. Para ello se realiza un estudio empírico sobre 169 PYME industriales, subvencionadas y no subvencionadas. Los datos del estudio empírico han sido recogidos a través de un cuestionario dirigido al gerente de la empresa. Los resultados muestran que las empresas que solicitan ayudas públicas cuentan con una mejor tecnología. Las empresas elegidas por la Administración para otorgar las ayudas tienen tecnología fuerte-buena, estrategia exploradora-analizadora y una mayor proporción de exportaciones. Finalmente se obtiene, al analizar el sesgo de información en las empresas que no solicitan ayudas, que las mejor informadas se caracterizan por tener un mayor grado de exportación y ser más antiguas.

  9. A tipologia ocupacional Erikson-Goldthorpe-Portocarero (EGP: uma avaliação analítica e empírica

    Directory of Open Access Journals (Sweden)

    Flavio Alex de Oliveira Carvalhaes

    2015-12-01

    Full Text Available Resumo As classes sociais são consideradas um conceito sociológico por excelência. Neste artigo, propomos uma avaliação empírica do conceito, motivada por questionamentos contemporâneos que têm sido críticos a análises que recorrem ao conceito de classe como dimensão heuristicamente interessante. Nosso esforço se concentra em uma validação da proposta popularmente conhecida como a tipologia EGP (Erikson-Goldthorpe-Portocarero. Através da utilização de uma técnica estatística, sensível ao padrão dos dados - a análise de classes latentes -, verificamos o padrão de associação da tipologia com aspectos relevantes do mercado de trabalho brasileiro. Como principal resultado que emerge a partir das análises empreendidas, apontamos uma série de restrições à proposta avaliada. Isso indica para a necessidade dos sociólogos e de outros pesquisadores interessados no trabalho com o conceito estarem sensíveis para as particularidades impostas pelo contexto brasileiro que impõe limites não triviais à sua validade empírica.

  10. La fuerza de los lazos: una exploración teórica y empírica de sus múltiples significados

    Directory of Open Access Journals (Sweden)

    Irene Cruz Gómez

    2013-01-01

    Full Text Available La fuerza del vínculo es una de las características recurrentemente estudiadas en las redes personales. Es un dato aparentemente sencillo de generar, con una potencial capacidad predictiva sobre los intercambios dentro de la relación y de la posición del contacto dentro de la red. Sin embargo, la gran diversidad de indicadores que se emplean en la literatura para medir esta fuerza del vínculo da fe de la vaguedad en la definición del concepto y las consecuentes dificultades para operativizarlo, dando lugar a resultados ambivalentes en su observación empírica. Con este trabajo de revisión teórica, metodológica y empírica se pre- tende ofrecer una base sobre la cual contribuir a la delimitación del concepto. Se propone una dimensionalización teórica de la noción, distinguiendo sus aspectos expresivos, sociales y estructurales, y a continuación se compara el comportamiento de diversos indicadores de las distintas dimensiones empleando una muestra de 441 redes personales y 13.230 relaciones provenientes de una encuesta realizada en Cataluña entre 2009 y 2010.

  11. Análise da Volatilidade do Índice Bovespa: um estudo empírico utilizando modelos da classe ARCH

    Directory of Open Access Journals (Sweden)

    Leiziane Neves de Ázara

    2007-05-01

    Full Text Available A utilização de estudos sobre volatil idade como instrumento de orientação de investimentos e classifica ção de riscos tem sido uma estratégia muito utilizada no mercado de capitais. Este artigo faz uma análise empírica da volatilidade dos retornos do índice Bovespa por meio de modelos da classe ARCH. Os resultados empíricos sugerem fortes sinais de persis- tência e assimetria da volatilidade dos retornos da série Além disso, todos os modelos da classe ARCH estima- dos tiveram um bom desempenho, destacando o modelo EGARCH (1,1, gaussiano, apresentando o melhor ajuste considerando os critérios de qualidade. Os resultados sugerem, também, a diversificação da carteira de investimentos como um importante instru- mento da administração do risco e de suas operações comerciais, uma vez que, os choques negativos e positivos têm impactos diferenciados sobre a volatilidade dos retornos.

  12. Template Reproduction of GRB Pulse Light Curves

    Science.gov (United States)

    Hakkila, Jon E.; Preece, R. D.; Loredo, T. J.; Wolpert, R. L.; Broadbent, M. E.

    2014-01-01

    A study of well-isolated pulses in gamma ray burst light curves indicates that simple models having smooth and monotonic pulse rises and decays are inadequate. Departures from the Norris et al. (2005) pulse shape are in the form of a wave-like pre-peak residual that is mirrored and stretched following the peak. Pulse shape departures are present in GRB pulses of all durations, but placement of the departures relative to pulse peaks correlates with asymmetry. This establishes an additional link between temporal structure and spectral evolution, as pulse asymmetry is related to initial hardness while pulse duration indicates the rate of hard-to-soft pulse evolution.

  13. 一种电磁脉冲前门耦合效应的事件分解评估方法%An affair-decomposability evaluation method to calculate the front-door coupling effect of electromagnetic pulse

    Institute of Scientific and Technical Information of China (English)

    肖金石; 任雄伟; 樊强

    2013-01-01

    电磁脉冲弹是一种利用辐射高功率电磁脉冲干扰/毁伤目标电子系统的新概念武器.为计算电磁脉冲通过前门耦合毁伤目标的效能,提出一种基于事件分解的效能评估方法,按时间序列将前门耦合-毁伤过程分为弹体爆炸辐射电磁脉冲、大气传输衰减、目标系统耦合3个子事件,分别用不同算法计算其发生效能.用该方法对美国MK84导弹搭载的电磁脉冲弹进行评估,得到具有一定参考价值的效能评估值.%Electromagnetic pulse (EMP) bomb is a kind of new concept weapon,which can be used to disturb or damage electronic system by radiating high power electromagnetic pulse. To calculate damage efficiency of high power EMP through front-door coupling, a kind of efficiency evaluation method based on affair-decomposability is raised. Front-door coupling - damage course is decomposed into three affairs in chronological sequence, which is EMP bomb radiating power, electromagnetic energy transmission and electromagnetic energy coupling into target system. Efficiency of these three affairs is calculated with different algorithms. Finally, type MK 84 electromagnetic pulse bomb of USA is evaluated using this method. Some conclusions about efficiency evaluation are gotten.

  14. Modelación empírica de flotación en columna a escala piloto

    Directory of Open Access Journals (Sweden)

    Simpson, J.

    2010-04-01

    úrgicos (ley de concentrado, ley de relaves, razón de enriquecimiento y recuperación en función de las variables operacionales que sean manipulables busca entregarle mayor libertad al operador y al ingeniero de procesos para lograr la sintonización operacional de la columna. El método empleado para el desarrollo de los modelos fue Stepwise Regression (Regresión por Pasos considerando relaciones empíricas entre variables operacionales y los resultados experimentales. Todos los modelos presentaron sobre un 90 % de exactitud, salvo uno de ellos que fue sobre 70 %.

  15. Research agenda shrimp pulse fishery

    NARCIS (Netherlands)

    Marlen, van B.; Rasenberg, M.M.M.; Verschueren, B.; Polet, H.

    2015-01-01

    In the recent decennia, many developments have taken place to improve the selectivity of the shrimp fishing gears. Recently, the development of a pulse gear for catching shrimps has taken up again as an opportunity to decrease discards, inspired by developments in the flatfish pulse fishery.

  16. Pulse oximetry for perioperative monitoring

    DEFF Research Database (Denmark)

    Pedersen, Tom; Møller, Ann Merete; Hovhannisyan, Karen

    2009-01-01

    Pulse oximetry is extensively used in the perioperative period and might improve patient outcomes by enabling an early diagnosis and, consequently, correction of perioperative events that might cause postoperative complications or even death. Only a few randomized clinical trials of pulse oximetry...

  17. A Single-Pulse Integrator

    DEFF Research Database (Denmark)

    Miller, Arne

    1974-01-01

    A single-pulse integrator is described. It gives a relative measure of the integral of the output signal from a coil monitor on the Risø 10 MeV linear accelerator, and displays the value on a digital voltmeter. The reproduccibility is found to be better than ±1% for an accelerated pulse charge...

  18. NMR in pulsed magnetic field

    KAUST Repository

    Abou-Hamad, Edy

    2011-09-01

    Nuclear magnetic resonance (NMR) experiments in pulsed magnetic fields up to 30.4 T focused on 1H and 93Nb nuclei are reported. Here we discuss the advantage and limitation of pulsed field NMR and why this technique is able to become a promising research tool. © 2011 Elsevier Inc. All Rights Reserved.

  19. Dexamethasone pulse therapy in pemphigus

    NARCIS (Netherlands)

    Toth, GG; van de Meer, JB; Jonkman, MF

    2002-01-01

    Pulse therapy with high-dose glucocorticoids was introduced 20 years ago as a treatment modality for autoimmune disease and transplant rejection. The most popular dermatological indication for pulse therapy is severe pemphigus. We reviewed the sequelae of 14 patients with pemphigus who were treated

  20. Research progress of the anti-inflammatory effect of EMP on periodontal cells%釉基质蛋白对牙周细胞抗炎作用的研究进展

    Institute of Scientific and Technical Information of China (English)

    陆嘉玲; 束蓉

    2016-01-01

    It has been widely proved that enamel matrix protein (EMP) can enhance periodontal regeneration. Recently, the anti⁃in⁃flammatory effect of EMP has also been discovered in many relevant studies. The article reviewed the current research process of the an⁃ti⁃inflammatory activity of EMP on several periodontal cells.%釉基质蛋白(enamel matrix protein,EMP)促进牙周组织再生的作用已得到大量研究证实。近来,随着EMP的研究进展,其抗炎作用也逐渐被发现。本文就EMP对多种牙周相关细胞的抗炎作用作一综述。

  1. Pulse oximetry for perioperative monitoring

    DEFF Research Database (Denmark)

    Pedersen, Tom; Nicholson, Amanda; Hovhannisyan, Karen

    2014-01-01

    . Results indicated that hypoxaemia was reduced in the pulse oximetry group, both in the operating theatre and in the recovery room. During observation in the recovery room, the incidence of hypoxaemia in the pulse oximetry group was 1.5 to three times less. Postoperative cognitive function was independent...... postoperative complications or even death. Only a few randomized clinical trials of pulse oximetry during anaesthesia and in the recovery room have been performed that describe perioperative hypoxaemic events, postoperative cardiopulmonary complications and cognitive dysfunction. OBJECTIVES: To study the use...... checked the reference lists of trials and review articles. The original search was performed in January 2005, and a previous update was performed in May 2009. SELECTION CRITERIA: We included all controlled trials that randomly assigned participants to pulse oximetry or no pulse oximetry during...

  2. Neurostimulation using subnanosecond electric pulses

    Science.gov (United States)

    Xiao, Shu; Pakhomov, Andrei; Guo, Fei; Polisetty, Swetha; Schoenbach, Karl H.

    2013-02-01

    We have for the first time recorded action potentials in rat hippocampus neurons when they were stimulated by subnanosecond electric pulses. The preliminary results show that applying a series of pulses allowed the accumulation of depolarization before activating the voltage gated channels. The depolarization only occurred when the electric pulses were applied. It is unclear whether the depolarization is caused by the charge accumulation across the membrane or the cation influx due to the membrane permeabilization. We have also conducted an electromagnetic simulation of delivering subnanosecond pulses to tissues using an impulse radiating antenna. The results show that the pulses can be confined in the deep region in the brain but the amplitude is reduced significantly due to the attenuation of the tissues. A partially lossy dielectric lens may be used to reverse the decreasing trend of the electric field.

  3. Pre-earthquake Magnetic Pulses

    CERN Document Server

    Scoville, John; Freund, Friedemann

    2014-01-01

    A semiconductor model of rocks is shown to describe unipolar magnetic pulses, a phenomenon that has been observed prior to earthquakes. These pulses are observable because their extremely long wavelength allows them to pass through the Earth's crust. Interestingly, the source of these pulses may be triangulated to pinpoint locations where stress is building deep within the crust. We couple a semiconductor drift-diffusion model to a magnetic field in order to describe the electromagnetic effects associated with electrical currents flowing within rocks. The resulting system of equations is solved numerically and it is seen that a volume of rock may act as a diode that produces transient currents when it switches bias. These unidirectional currents are expected to produce transient unipolar magnetic pulses similar in form, amplitude, and duration to those observed before earthquakes, and this suggests that the pulses could be the result of geophysical semiconductor processes.

  4. La percepción del esfuerzo publicitario como antecedente en el modelo de medición del valor de marca. Contrastación empírica para el caso de un producto duradero.

    OpenAIRE

    Villarejo Ramos, Ángel Francisco

    2002-01-01

    En el presente trabajo pretendemos establecer una base teórica y empírica para la consideración de la influencia que ejerce el esfuerzo publicitario percibido por el mercado en la determinación del valor de marca del producto publicitado. Tras la revisión teórica que sustenta la posibilidad de aplicar técnicas de análisis basadas en los modelos de ecuaciones estructurales planteamos la confirmación empírica, en su caso, de las relaciones existen...

  5. Bancos Cooperativos y Sociedades de Ahorro y Crédito en El Salvador: modelo de supervisión prudencial y análisis empírico del coeficiente de solvencia

    OpenAIRE

    Hernández, Ana Verónica

    2013-01-01

    Estudio bibliográfico empírico, con el que se presenta una propuesta de supervisión para la superintendencia financiera de El Salvador, que incluye requisitos mínimos a considerar por el auditor, tomando como base Basilea II, III y siguiendo el Modelo OSFI de Canadá. Además se presenta un estudio empírico sobre los determinantes del coeficiente patrimonial en bancos cooperativos y sociedades de ahorro y crédito de El Salvador. Economía Financiera y Contabilidad Máster en Investigación ...

  6. Influence of the external component on the damage of the bipolar transistor induced by the electromagnetic pulse

    Science.gov (United States)

    Xiaowen, Xi; Changchun, Chai; Xingrong, Ren; Yintang, Yang; Zhenyang, Ma; Jing, Wang

    2010-07-01

    A study on the influence of the external resistor and the external voltage source during the injection of the electromagnetic pulse (EMP) into the bipolar transistor (BJT) is carried out. Research shows that the increase of the external resistor Rb at base makes the burnout time of the device decrease slightly, the increase of the external voltage source Vbe at base can aid the damage of the device when the magnitude of the injecting voltage is relatively low and has little influence when the magnitude is sufficiently high causing the device appearing the PIN structure damage, and the increase of the external resistor Re can remarkably reduce the voltage drops added to the device and improve the durability of the device. In the final analysis, the effect of the external circuit component on the BJT damage is the influence on the condition which makes the device appear current-mode second breakdown.

  7. Influence of the external component on the damage of the bipolar transistor induced by the electromagnetic pulse

    Energy Technology Data Exchange (ETDEWEB)

    Xi Xiaowen; Chai Changchun; Ren Xingrong; Yang Yintang; Ma Zhenyang; Wang Jing, E-mail: xixiaowen523103@163.co [Key Laboratory of Ministry of Education for Wide Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi' an 710071 (China)

    2010-07-15

    A study on the influence of the external resistor and the external voltage source during the injection of the electromagnetic pulse (EMP) into the bipolar transistor (BJT) is carried out. Research shows that the increase of the external resistor R{sub b} at base makes the burnout time of the device decrease slightly, the increase of the external voltage source V{sub be} at base can aid the damage of the device when the magnitude of the injecting voltage is relatively low and has little influence when the magnitude is sufficiently high causing the device appearing the PIN structure damage, and the increase of the external resistor R{sub e} can remarkably reduce the voltage drops added to the device and improve the durability of the device. In the final analysis, the effect of the external circuit component on the BJT damage is the influence on the condition which makes the device appear current-mode second breakdown.

  8. Pulse shaping using a spatial light modulator

    CSIR Research Space (South Africa)

    Botha, N

    2009-07-01

    Full Text Available Femtosecond pulse shaping can be done by different kinds of pulse shapers, such as liquid crystal spatial light modulators (LC SLM), acousto optic modulators (AOM) and deformable and movable mirrors. A few applications where pulse shaping...

  9. Pulse source requirements for OTDM systems

    DEFF Research Database (Denmark)

    Clausen, Anders; Poulsen, Henrik Nørskov; Oxenløwe, Leif Katsuo

    2003-01-01

    A simulation model for investigating the impact of incoherent crosstalk due to pulse tail overlapping is proposed. Requirements to pulse width and pulse tail extinction ratio introducing a maximum of 1 dB penalty is extracted....

  10. Bomb pulse biology

    Energy Technology Data Exchange (ETDEWEB)

    Falso, Miranda J. Sarachine [Center for Accelerator Mass Spectrometry, Mail Stop L-397, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94551 (United States); Buchholz, Bruce A., E-mail: buchholz2@llnl.gov [Center for Accelerator Mass Spectrometry, Mail Stop L-397, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94551 (United States)

    2013-01-15

    The past decade has seen an explosion in use of the {sup 14}C bomb pulse to do fundamental cell biology. Studies in the 1960s used decay counting to measure tissue turnover when the atmospheric {sup 14}C/C concentration was changing rapidly. Today bulk tissue measurements are of marginal interest since most of the carbon in the tissue resides in proteins, lipids and carbohydrates that turn over rapidly. Specific cell types with specialized functions are the focus of cell turnover investigations. Tissue samples need to be fresh or frozen. Fixed or preserved samples contain petroleum-derived carbon that has not been successfully removed. Cell or nuclear surface markers are used to sort specific cell types, typically by fluorescence-activated cell sorting (FACS). Specific biomolecules need to be isolated with high purity and accelerator mass spectrometry (AMS) measurements must accommodate samples that generally contain less than 40 {mu}g of carbon. Furthermore, all separations must not add carbon to the sample. Independent means such as UV absorbance must be used to confirm molecule purity. Approaches for separating specific proteins and DNA and combating contamination of undesired molecules are described.

  11. Pulsed electron beam precharger

    Energy Technology Data Exchange (ETDEWEB)

    Finney, W.C. (ed.); Shelton, W.N.

    1990-01-01

    Electrostatic collection of a high resistivity aerosol using the Electron Beam Precipitator (EBP) collecting section was demonstrated during this reporting period (Quarter Five). Collection efficiency experiments were designed to confirm and extend some of the work performed under the previous contract. The reason for doing this was to attempt to improve upon the collection efficiency of the precipitator alone when testing with a very high resistivity, moderate-to-high concentration dust load. From the collector shakedown runs, a set of suitable operational parameters were determined for the downstream electrostatic collecting sections of the Electron Beam Precipitator wind tunnel. These parameters, along with those for the MINACC electron beam, will generally be held constant while the numerous precharging parameters are varied to produce an optimum particle charge. The electrostatic collector experiments were part of a larger, comprehensive investigation on electron beam precharging of high resistivity aerosol particles performed during the period covered by Quarters Five, Six, and Seven. This body of work used the same experimental apparatus and procedures and the experimental run period lasted nearly continuously for six months. A summary of the Quarter Five work is presented in the following paragraphs. Section II-A of TPR 5 contains a report on the continuing effort which was expended on the modification and upgrade of the pulsed power supply and the monitoring systems prior to the initiation of the electron beam precharging experimental work.

  12. Magnetic Alignment of Pulsed Solenoids Using the Pulsed Wire Method

    Energy Technology Data Exchange (ETDEWEB)

    Arbelaez, D.; Madur, A.; Lipton, T.M.; Waldron, W.L.; Kwan, J.W.

    2011-04-01

    A unique application of the pulsed-wire measurement method has been implemented for alignment of 2.5 T pulsed solenoid magnets. The magnetic axis measurement has been shown to have a resolution of better than 25 {micro}m. The accuracy of the technique allows for the identification of inherent field errors due to, for example, the winding layer transitions and the current leads. The alignment system is developed for the induction accelerator NDCX-II under construction at LBNL, an upgraded Neutralized Drift Compression experiment for research on warm dense matter and heavy ion fusion. Precise alignment is essential for NDCX-II, since the ion beam has a large energy spread associated with the rapid pulse compression such that misalignments lead to corkscrew deformation of the beam and reduced intensity at focus. The ability to align the magnetic axis of the pulsed solenoids to within 100 pm of the induction cell axis has been demonstrated.

  13. Causality effects on accelerating light pulses

    National Research Council Canada - National Science Library

    Kaminer, Ido; Lumer, Yaakov; Segev, Mordechai; Christodoulides, Demetrios N

    2011-01-01

    .... We explore the effects of causality, and find that, whereas decelerating pulses can asymptotically reach zero group velocity, pulses that accelerate towards infinite group velocity inevitably break...

  14. Insect cells are superior to Escherichia coli in producing malaria proteins inducing IgG targeting PfEMP1 on infected erythrocytes

    Directory of Open Access Journals (Sweden)

    Joergensen Louise

    2010-11-01

    Full Text Available Abstract Background The PFD1235w Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1 antigen is associated with severe malaria in children and can be expressed on the surface of infected erythrocytes (IE adhering to ICAM1. However, the exact three-dimensional structure of this PfEMP1 and its surface-exposed epitopes are unknown. An insect cell and Escherichia coli based system was used to express single and double domains encoded by the pfd1235w var gene. The resulting recombinant proteins have been evaluated for yield and purity and their ability to induce rat antibodies, which react with the native PFD1235w PfEMP1 antigen expressed on 3D7PFD1235w-IE. Their recognition by human anti-malaria antibodies from previously infected Tanzanian donors was also analysed. Methods The recombinant proteins were run on SDS-PAGE and Western blots for quantification and size estimation. Insect cell and E. coli-produced recombinant proteins were coupled to a bead-based Luminex assay to measure the plasma antibody reactivity of 180 samples collected from Tanzanian individuals. The recombinant proteins used for immunization of rats and antisera were also tested by flow cytometry for their ability to surface label 3D7PFD1235w-IE. Results All seven pAcGP67A constructs were successfully expressed as recombinant protein in baculovirus-infected insect cells and subsequently produced to a purity of 60-97% and a yield of 2-15 mg/L. By comparison, only three of seven pET101/D-TOPO constructs expressed in the E. coli system could be produced at all with purity and yield ranging from 3-95% and 6-11 mg/L. All seven insect cell, but only two of the E. coli produced proteins induced antibodies reactive with native PFD1235w expressed on 3D7PFD1235w-IE. The recombinant proteins were recognized in an age- and transmission intensity-dependent manner by antibodies from 180 Tanzanian individuals in a bead-based Luminex assay. Conclusions The baculovirus based insect cell

  15. Fast radio bursts counterparts in the scenario of supergiant pulses

    Science.gov (United States)

    Popov, S. B.; Pshirkov, M. S.

    2016-10-01

    We discuss identification of possible counterparts and persistent sources related to fast radio bursts (FRBs) in the framework of the model of supergiant pulses from young neutron stars with large spin-down luminosities. In particular, we demonstrate that at least some of the sources of FRBs can be observed as ultraluminous X-ray sources (ULXs). At the moment no ULXs are known to be coincident with localization areas of FRBs. We searched for a correlation of FRB positions with galaxies in the 2MASS Redshift survey catalogue. Our analysis produced statistically insignificant overabundance (p-value ≈ 4 per cent) of galaxies in error boxes of FRBs. In the very near future with even modestly increased statistics of FRBs and with the help of dedicated X-ray observations and all-sky X-ray surveys it will be possible to decisively prove or falsify the supergiant pulses model.

  16. Pulsed ultrasonic stir welding method

    Science.gov (United States)

    Ding, R. Jeffrey (Inventor)

    2013-01-01

    A method of performing ultrasonic stir welding uses a welding head assembly to include a plate and a rod passing through the plate. The rod is rotatable about a longitudinal axis thereof. In the method, the rod is rotated about its longitudinal axis during a welding operation. During the welding operation, a series of on-off ultrasonic pulses are applied to the rod such that they propagate parallel to the rod's longitudinal axis. At least a pulse rate associated with the on-off ultrasonic pulses is controlled.

  17. Hyper dispersion pulse compressor for chirped pulse amplification systems

    Science.gov (United States)

    Barty, Christopher P. J.

    2011-11-29

    A grating pulse compressor configuration is introduced for increasing the optical dispersion for a given footprint and to make practical the application for chirped pulse amplification (CPA) to quasi-narrow bandwidth materials, such as Nd:YAG. The grating configurations often use cascaded pairs of gratings to increase angular dispersion an order of magnitude or more. Increased angular dispersion allows for decreased grating separation and a smaller compressor footprint.

  18. Effects of Electromagnetic Pulses on a Multilayered System

    Science.gov (United States)

    2014-07-01

    University at Buffalo, 230 Davis Hall, Buffalo, NY 14260 H. L. Moore, P. Haney US Army ARDEC, AMSRD-AAR-MEM, Building 65 S, Picatinny Arsenal, NJ...types of EMPs that are of concern regarding electronics and system infrastructures; they are high-altitude EMP ( HEMP ) generated from nuclear...is for 3-D full-wave electromagnetic field simulation and high frequency and high speed components [2]. The model used was designed and imported

  19. Pulse-to-pulse Diagnostics at High Reprate

    Science.gov (United States)

    Green, Bertram; Kovalev, Sergey; Golz, Torsten; Stojanovich, Nikola; Fisher, Alan; Kampfrath, Tobias; Gensch, Michael

    2016-03-01

    Femtosecond level diagnostic and control of sub-picosecond electron bunches is an important topic in modern accelerator research. At the same time new linear electron accelerators based on quasi-CW SRF technology will be the drivers of many future 4th Generation lightsources such as X-ray free electron lasers. A high duty cycle, high stability and online pulse to pulse diagnostic at these new accelerators are crucial ingredients to the success of these large scale facilities. A novel THz based online monitor concept is presented that has the potential to give access to pulse to pulse information on bunch form, arrival time and energy at high repetition rate and down to sub pC charges. We furthermore show experimentally that pulse to pulse arrival time measurements can be used to perform pump-probe experiments with a temporal resolution in the few-fs regime and an exceptional dynamic range. Our scheme has been tested at the superradiant test facility TELBE, but can be readily transferred to other SRF accelerator driven photon sources, such as X-FELs.

  20. Pulsed light and pulsed electric field for foods and eggs.

    Science.gov (United States)

    Dunn, J

    1996-09-01

    Two new technologies for use in the food industry are described. The first method discussed uses intense pulse of light. This pulsed light (PureBright) process uses short duration flashes of broad spectrum "white" light to kill all exposed microorganisms, including vegetative bacteria, microbial and fungal spores, viruses, and protozoan oocysts. Each pulse, or flash, of light lasts only a few hundred millionths of a second (i.e., a few hundred microseconds). The intensity of each flash of light is about 20,000 times the intensity of sunlight at the earth's surface. The flashes are typically applied at a rate of about one to tens of flashes per second. For most applications, a few flashes applied in a fraction of a second provide an effective treatment. High microbial kill can be achieved, for example, on the surfaces of packaging materials, on packaging and processing equipment, foods, and medical devices as well as on many other surfaces. In addition, some bulk materials such as water and air that allow penetration of the light can be sterilized. The results of tests to measure the effects of pulsed light on Salmonella enteritiditis on eggs are presented. The second method discussed uses multiple, short duration, high intensity electric field pulses to kill vegetative microorganisms in pumpable products. This pulsed electric field (or CoolPure) process can be applied at modest temperatures at which no appreciable thermal damage occurs and the original taste, color, texture, and functionality of products can be retained.

  1. Didáctica del vocabulario en la Enseñanza Secundaria Obligatoria (estudio empírico

    Directory of Open Access Journals (Sweden)

    Jesús MORENO RAMOS

    2009-11-01

    Full Text Available RESUMEN: Con esta investigación educativa se ha verificado que la competencia léxica así como las habilidades productivas y receptivas de la lengua, se incrementan sustancialmente tras la aplicación de una programación sistemática de vocabulario. Para tal fin, se procedió a un estudio empírico. Los sujetos de la muestra seleccionada fueron setenta estudiantes de catorce y quince años del Instituto La Malladeta, de Villajoyosa (Alicante, durante el curso académico 96/97. El programa comprendía dos metodologías. Una de estilo tradicional (grupo de control y otra de estilo innovador (grupo experimental. En ambos grupos se aplicó el mismo vocabulario básico. Para la primera estrategia didáctica se utilizaron ejercicios como los recogidos por los libros de texto en los diez últimos años. Para la segunda estrategia didáctica se emplearon constelaciones léxicas y prácticas dramáticas (simulación, juego de personajes y creación de guiones escritos. Con esta intervención se han logrado de manera satisfactoria fines lingüísticos y educativos importantes, como son la integración en el aula, el crecimiento personal, el fomento del trabajo cooperativo y el aprecio hacia la lengua.ABSTRACT: This study has been undertaken to show that lexical proficiency and passive and productive competence in a language can be considerably improved by means of a systematic approach to vocabulary. To prove the point, an empirical study was carried out among 70 pupils between the ages of 14 and 15 during the academic year 1996/97. The pupils were from the State Secondary School «La Malladeta» in Villajoyosa, Alicante, Spain. Two methodological systems were used. The first, which was applied to the control group, was a traditional one and the second, applied to the experimental group, was an innovative one. In both groups the same basic vocabulary was use. In the traditional group, exercises were take from text books edited over the last 10 years

  2. Engineering surveying

    CERN Document Server

    Schofield, W

    2001-01-01

    The aim of Engineering Surveying has always been to impart and develop a clear understanding of the basic topics of the subject. The author has fully revised the book to make it the most up-to-date and relevant textbook available on the subject.The book also contains the latest information on trigonometric levelling, total stations and one-person measuring systems. A new chapter on satellites ensures a firm grasp of this vitally important topic.The text covers engineering surveying modules for civil engineering students on degree courses and forms a reference for the engineering surveying module in land surveying courses. It will also prove to be a valuable reference for practitioners.* Simple clear introduction to surveying for engineers* Explains key techniques and methods* Details reading systems and satellite position fixing

  3. Treatment of Persistent Facial Postinflammatory Hyperpigmentation With Novel Pulse-in-Pulse Mode Intense Pulsed Light.

    Science.gov (United States)

    Park, Ji-Hye; Kim, Jung-In; Kim, Won-Serk

    2016-02-01

    Postinflammatory hyperpigmentation (PIH) is an acquired hypermelanosis induced by various causes including inflammatory dermatoses, injury, or cosmetic procedures, such as lasers or chemical peels, and it tends to affect dark-skinned people with greater frequency and severity. There are a variety of treatment options for PIH, including topical agents, chemical peels, laser, and light therapy. However, the results are not up to expectation. The purpose of this study was to examine the clinical efficacy and safety of novel pulse-in-pulse mode intense pulsed light (IPL) for the treatment of persistent facial PIH in Korean patients. Twenty-five Korean female patients (Fitzpatrick skin types III-V) with persistent facial PIH were enrolled in the study. The patients were treated with novel pulse-in-pulse mode IPL for 4 sessions at 1-week interval and 4 sessions at 2-week intervals. Treatment efficacy and patient satisfaction were evaluated using photographs and questionnaires. After 2 months of all treatments, 23 patients (92%) had more than 50% improvement and 22 patients (88%) were satisfied with the treatments. No adverse effects or aggravations were reported. The pulse-in-pulse mode IPL treatment is effective and safe for persistent facial PIH in dark-skinned patients.

  4. Intense pulsed neutron source

    Science.gov (United States)

    The IPNS Progress Report 10th Anniversary Edition is being published in recognition of the first ten years of successful IPNS operation. To emphasize the significance of this milestone, we wanted this report to stand apart from the previous IPNS Progress Reports, and the best way to do this, we thought, was to make the design and organization of the report significantly different. In their articles, authors were asked to emphasize not only advances made since IPNS began operating but also the groundwork that was laid at its predecessor facilities - Argonne's ZING-P and ZING-P' prototype pulsed neutron sources and CP-5 reactor. Each article stands as a separate chapter in the report, since each represents a particular instrument or class of instruments, system, technique, or area of research. In some cases, contributions were similar to review articles in scientific journals, complete with extensive lists of references. Ten-year cumulative lists of members of IPNS committees and of scientists who have visited or done experiments at IPNS were assembled. A list of published and 'in press' articles in journals, books, and conference proceedings, resulting from work done at IPNS during the past ten years, was compiled. And archival photographs of people and activities during the ten-year history of IPNS were located and were used liberally throughout the report. The titles of the chapters in this report are: accelerator; computer; radiation effects; powder; stress; single crystal; superconductivity; amorphous; small angle; reflection; quasielastic; inelastic; inelastic magnetic; deep inelastic; user program; the future; and publications.

  5. Next generation Chirped Pulse Amplification

    Energy Technology Data Exchange (ETDEWEB)

    Nees, J.; Biswal, S.; Mourou, G. [Univ. Michigan, Center for Ultrafast Optical Science, Ann Arbor, MI (United States); Nishimura, Akihiko; Takuma, Hiroshi

    1998-03-01

    The limiting factors of Chirped Pulse Amplification (CPA) are discussed and experimental results of CPA in Yb:glass regenerative amplifier are given. Scaling of Yb:glass to the petawatt level is briefly discussed. (author)

  6. Rapidly pulsed helium droplet source

    Energy Technology Data Exchange (ETDEWEB)

    Pentlehner, Dominik; Riechers, Ricarda; Dick, Bernhard; Slenczka, Alkwin [Institute for Physical and Theoretical Chemistry, University of Regensburg, 93053 Regensburg (Germany); Even, Uzi; Lavie, Nachum; Brown, Raviv; Luria, Kfir [Sackler Faculty of Exact Sciences, School of Chemistry, Tel Aviv University, Ramat Aviv, 69978 Tel Aviv (Israel)

    2009-04-15

    A pulsed valve connected to a closed-cycle cryostat was optimized for producing helium droplets. The pulsed droplet beam appeared with a bimodal size distribution. The leading part of the pulse consists of droplets suitable for doping with molecules. The average size of this part can be varied between 10{sup 4} and 10{sup 6} helium atoms, and the width of the distribution is smaller as compared to a continuous-flow droplet source. The system has been tested in a single pulse mode and at repetition rates of up to 500 Hz with almost constant intensity. The droplet density was found to be increased by more than an order of magnitude as compared to a continuous-flow droplet source.

  7. Low-noise pulse conditioner

    Science.gov (United States)

    Bird, D.A.

    1981-06-16

    A low-noise pulse conditioner is provided for driving electronic digital processing circuitry directly from differentially induced input pulses. The circuit uses a unique differential-to-peak detector circuit to generate a dynamic reference signal proportional to the input peak voltage. The input pulses are compared with the reference signal in an input network which operates in full differential mode with only a passive input filter. This reduces the introduction of circuit-induced noise, or jitter, generated in ground referenced input elements normally used in pulse conditioning circuits, especially speed transducer processing circuits. This circuit may be used for conditioning the sensor signal from the Fidler coil in a gas centrifuge for separation of isotopic gaseous mixtures.

  8. Pulse tube refrigerator; Parusukan reitoki

    Energy Technology Data Exchange (ETDEWEB)

    Hozumi, Yoshikazu [University of Tsukuba, Tsukuba (Japan); Shiraishi, Masao [Hiroshima University, Hiroshima (Japan)

    1999-06-05

    In the cryogenic field, high temperature superconductivity and research and development of the peripheral technology are popular. Refrigerating machine development of the very low temperature is also one of the results. Research and development are mainly advanced as a refrigerating machine of the center for the aerospace plane installation. There is special and small very low temperature refrigerating machine called 'the pulse tube refrigerating machine' of which the practical application is also recently being attempted for the semiconductor cooling using high temperature superconductivity. At present, the basic research of elucidation of refrigeration phenomenon of pulse tube refrigerating machine and development of high-performance pulse tube refrigerating machine is carried out by experiment in the Ministry of International Trade and Industry Mechanical Engineering Lab., Agency of Industrial Sci. and Technology and numerical simulation in Chiyoda Corp. In this report, the pulse tube refrigerating machine is introduced, and the application in the chemical engineering field is considered. (NEDO)

  9. Damage effect and mechanism of the GaAs pseudomorphic high electron mobility transistor induced by the electromagnetic pulse

    Science.gov (United States)

    Xiao-Wen, Xi; Chang-Chun, Chai; Gang, Zhao; Yin-Tang, Yang; Xin-Hai, Yu; Yang, Liu

    2016-04-01

    The damage effect and mechanism of the electromagnetic pulse (EMP) on the GaAs pseudomorphic high electron mobility transistor (PHEMT) are investigated in this paper. By using the device simulation software, the distributions and variations of the electric field, the current density and the temperature are analyzed. The simulation results show that there are three physical effects, i.e., the forward-biased effect of the gate Schottky junction, the avalanche breakdown, and the thermal breakdown of the barrier layer, which influence the device current in the damage process. It is found that the damage position of the device changes with the amplitude of the step voltage pulse. The damage appears under the gate near the drain when the amplitude of the pulse is low, and it also occurs under the gate near the source when the amplitude is sufficiently high, which is consistent with the experimental results. Project supported by the National Basic Research Program of China (Grant No. 2014CB339900), and the Open Fund of Key Laboratory of Complex Electromagnetic Environment Science and Technology, China Academy of Engineering Physics (CAEP) (Grant No. 2015-0214.XY.K).

  10. ¿Cómo afectan los impuestos a la calidad del resultado? evidencia empírica en las empresas espalas no cotizadas

    Directory of Open Access Journals (Sweden)

    Juan Monterrey Mayoral

    2009-01-01

    Full Text Available El presente estudio tiene por objeto analizar empíricamente en qué medida los impuestos afectan a la calidad del resultado en las compañías españolas no cotizadas. Tomando una amplia muestra de empresas, documentamos en qué circunstancias la tributación puede reducir la calidad de la información contable. No obstante, el objetivo de reducir costes fiscales está confinado a las compañías que no presentan riesgos derivados del endeudamiento. Nuestros resultados se mantienen robustos tras controlar las características corporativas que la literatura señala como determinantes innatos de la calidad contable y empleando especificaciones alternativas.

  11. Simulación de ensayos triaxiales cíclicos con presión de confinamiento constante y variable empleando ecuaciones empíricas

    Directory of Open Access Journals (Sweden)

    Hugo Alexander Rondón Quintana

    2009-01-01

    para intentar predecir la acumulación de las deformaciones permanentes que experimentan materiales granulares no tratados (GNT en ensayos triaxiales cíclicos con presión de confinamiento constante (PCC y variable (PCV. Con base en el análisis de dichas ecuaciones, se escogieron las más utilizadas en el mundo con el fin de simular el comportamiento que experimentó un GNT en ensayos tipo PCC y PCV. Las simulaciones realizadas demuestran que la mayor parte de las ecuaciones empíricas que se utilizan para predecir la acumulación de la deformación permanente de un material granular bajo carga cíclica no pueden reproducir su comportamiento en ensayos PCC y PCV. Adicionalmente, los parámetros que emplean dichas ecuaciones no son constantes del material.

  12. Adicción a internet y móvil : una revisión de estudios empíricos españoles

    OpenAIRE

    Sánchez Carbonell, Xavier; Fúster, Héctor; Chamarro Lusar, Andrés; Oberst, Ursula

    2012-01-01

    Determinar los factores que diferencian el uso de Internet y móvil saludable del patológico. Método: Se revisaron doce estudios empíricos publicados por investigadores españoles sobre adicción a Internet y teléfono móvil entre 2002 y 2011, obtenidos a partir de una búsqueda en PsycINFO y en Psicodoc. Resultados y Discusión: Se observó una relación entre el uso problemático de Internet y diversos trastornos psicológicos y entre el uso problemático y el tiempo conectado. La comunicación alterad...

  13. El Síndrome de "Burnout" o el desgaste profesional (II: Estudio empírico de los profesionales gallegos del área de Salud Mental.

    Directory of Open Access Journals (Sweden)

    E Álvarez Gallego

    1991-01-01

    Full Text Available Este trabajo supone una aproximación empírica al síndrome de "Burnout". Para ello se ha tomado un grupo de profesionales gallegos del área de Salud Mental. Los instrumentos utilizados para operativizar las variables han sido, el Maslach Burnout Inventory (M.B.I. de Maslach and Jackson para la medición del "desgaste profesional" y la Escala de Clima Social en el Trabajo (W.E.S. de R.H. Moos. Los resultados muestran la presencia de un considerable cansancio emocional como resultado del contexto laboral, y dentro de los factores intervinientes, es la variable presión la que de manera más clara influye en el surgimiento del stress crónico en los profesionales de Salud Mental

  14. Análisis de la Simplificación de Expresiones Numéricas en Español mediante un Estudio Empírico

    Directory of Open Access Journals (Sweden)

    Susana Bautista

    2012-12-01

    Full Text Available En este artículo se presentan los resultados de un estudio empírico llevado a cabo con un corpus paralelo de textos originales y simplificados a mano, y una posterior encuesta online, con el objetivo de identificar operaciones de simplificación de expresiones numéricas en español. Consideramos una "expresión numérica" como una frase que expresa una cantidad que puede venir acompañada de un modificador numérico, como por ejemplo casi un cuarto. Los resultados se analizan considerando las expresiones numéricas en oraciones con y sin contexto, a partir del análisis del corpus y del análisis de los resultados recogidos en la encuesta. Consideramos como trabajo futuro llevar a cabo una implementación computacional de las reglas de transformación extraídas.

  15. Tradução de sexto empírico, ‘Contra os astrólogos’, 1-22

    Directory of Open Access Journals (Sweden)

    Rodrigo Pinto de Brito

    2015-08-01

    Full Text Available Tradução grego-português de Sexto Empírico, Contra os astrólogos, 1-22 (= M V 1-22, a partir da fixação de Bekker (BEKKER, I. Sextus Empiricus [opera omnia]. Berlim: Typis et Imprensis Ge. Reimeri, 1842, adotando as emendas de H. Mutschmann (MUTSCHMANN, H. Sexti Empirici Opera. v. III. Leipzig: Bibliotheca Scriptorum Graecorum et Romanorum Teubneriana, 1912. Para cotejo, usamos a mui influente versão latina de Henri Estienne e Gentian Hervet (STEPHANI, H.; HERVET, G. Sexti Empirici Opera Graeca et Latini. Leipzig: Sumptu Librariae Kuehnianae, 1841, além da versão inglesa de R. G. Bury, a romena de A. M. Frenkian, as italianas de A. Russo e de E. Spinelli, a espanhola de J. B. Cavero e a francesa de P. Pellegrin, C. Dalimier, D. Delattre, J. Dellatre e B. Prérez.

  16. Structural Studies on Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Malaria Antigens Using Small Angle X-Ray Scattering (SAXS)

    DEFF Research Database (Denmark)

    Christoffersen, Stig

    and allow infected erythrocytes to attach to endothelial cells and tissues. As a consequence infected erythrocytes sequester in the bloodstream, clotting blood vesicles and leading to severe and potentially fatal disease symptoms. The PfEMP1 proteins are multidomain antigens consisting of two types......-ray scattering from solutions and has in recent years proven very effective for obtaining structural information in the 10-15 Å resolution range for proteins. The technique is especially valuable for proteins that have proven difficult to crystallize for macromolecular high-resolution (... purposes. Macromolecular crystallography is typically the biophysical method of choice for obtaining detailed structural information but it unfortunately requires the formation of X-ray scattering protein crystals. The protein crystallization step remains a major bottleneck for X-ray protein...

  17. Impacto de la innovación sobre el rendimiento de la MIPYME: un estudio empírico en Colombia

    Directory of Open Access Journals (Sweden)

    EDGAR JULIÁN GÁLVEZ ALBARRACÍN

    2012-01-01

    Full Text Available El objetivo de este trabajo es verificar empíricamente la relación existente entre el grado de innovación de la empresa y su rendimiento, para lo cual se realiza un estudio con sesenta micro, pequeñas y medianas empresas (MIPYME de mediana y alta tecnología de la ciudad de Cali (Colombia. Los resultados muestran que la innovación en productos y en procesos ejerce una influencia positiva sobre el rendimiento de la MIPYME. Estos hallazgos refuerzan los postulados que muestran a la innovación como una ventaja competitiva sostenible, así mismo pueden ser de utilidad para los empresarios, al constatar la necesidad de innovar para mejorar su competitividad y para la administración pública en su papel de promotora de la innovación a través de programas de apoyo financiero y no financiero.

  18. Analysis on Missile Battle Protective Countermeasure Based on the EMP Environment%基于EMP环境下的导弹作战防护对策分析

    Institute of Scientific and Technical Information of China (English)

    俞坤东; 高桂清; 张欧亚

    2007-01-01

    EMP武器以其极强的破坏性在现代战争中展现出了显著的作战效能.为了提高EMP 环境下导弹作战防护能力,简单分析了EMP的产生过程,阐述了EMP武器在作战运用中的干扰、软(硬)杀伤的作用机理,研究了EMP环境对导弹及测试设备、指挥系统、计算机系统的影响,提出了导弹作战中对EMP的防护应采取设置法拉第笼、可靠接地、滤波等防护对策.

  19. EMP径向滑动轴承边界滑移现象研究%Study on the Interface Slippage of EMP Circular Sliding Bearing

    Institute of Scientific and Technical Information of China (English)

    袁斌; 张国贤; 吴白羽; 楮泽伟

    2000-01-01

    弹性金属塑料瓦(EMP)径向滑动轴承是一种新型的轴承,由于轴瓦所采用的复合材料的特殊特性使得其表面能远低于传统的金属瓦轴承,从而有可能存在油膜边界滑移现象.本文对EMP径向滑动轴承油膜边界滑移现象进行了实验研究,再次证实了边界滑移现象的存在,并推导出了EMP径向滑动轴承油膜边界滑移速度的公式.

  20. Estimativa dos pKa da Rutina empregando modelos semi-empíricos de cálculo mecânico-quântico

    OpenAIRE

    Euqueres, Jander Silva

    2009-01-01

    Neste trabalho, propriedades moleculares e termodinâmicas da molécula da rutina na fase gasosa e em meio aquoso, com a inserção de moléculas discretas de água em posições específicas, foram estudadas por meios de cálculos mecânico quânticos, utilizando especificamente como ferramenta os métodos semi-empíricos AM1 e o PM6 para o cálculo teórico do pKa. A inserção de moléculas discretas de água visou uma melhor descrição da interação soluto-solvente com o mínimo de demanda com...

  1. Evolución y determinantes de las exportaciones industriales regionales: evidencia empírica para Colombia (1977-2002

    Directory of Open Access Journals (Sweden)

    Lotero Contreras Jorge

    2011-09-01

    Full Text Available
    Este artículo examina el impacto de las variables macroeconómicas, de la productividad y de la
    geografía sobre las exportaciones industriales colombianas entre 1977 y 2002, usando datos de la
    Encuesta Nacional Manufacturera y de Comercio Exterior del DANE. El estudio se centra en las
    exportaciones al mundo, a Estados Unidos y a la Comunidad Andina de Naciones-CAN. La
    estrategia empírica incluye análisis de datos de panel cuyos resultados sugieren que para los
    mercados considerados, la distancia, la productividad y la protección efectiva tienen un efecto
    apreciable –aunque diferenciado–, sobre el comportamiento de las exportaciones industriales

  2. Teoria Instrumental dos Stakeholders em Ambientes Turbulentos: Uma Verificação Empírica Utilizando Doações Políticas e Sociais

    Directory of Open Access Journals (Sweden)

    Rosilene Marcon

    2008-01-01

    empresas doadoras e não doadoras (grupo de controle. No segundo modelo, equações estruturais, verifica-se a importância da intensidade do relacionamento (mediadora na relação entre a orientação para os stakeholders e performance com os stakeholders políticos e sociais, em firmas doadoras. A teoria instrumental não encontrou suporte empírico em ambos os modelos. Os resultados sugerem que o mercado ainda percebe a gestão dos stakeholders como custo para as empresas, podendo a intensidade do relacionamento com os stakeholders ser explicada por um construto unidimensional, mensurado por indicadores que descrevem o contexto organizacional.

  3. Distribución condicional de los retornos de la tasa de cambio colombiana: un ejercicio empírico a partir de modelos GARCH univariados.

    Directory of Open Access Journals (Sweden)

    Santiago Gallón Gómez

    2010-05-01

    Full Text Available Un conjunto de modelos GARCH multivariados son estimados y su validez empírica comparada a partir del cálculo de la medida VaR, para los retornos diarios de la tasa de cambio nominal del peso colombiano con respecto al dólar americano, euro, libra esterlina y yen japonés en el periodo 1999–2005. La comparación de las estimaciones para la matriz de covarianza condicional y los resultados obtenidos para la proporción de fallo y el contraste de cuantil dinámico de Engle y Manganelli (2004 presentan evidencia a favor del modelo de correlación condicional constante.

  4. Restricciones a la financiación de la PYME en México: una aproximación empírica

    OpenAIRE

    Alicia Gómez Martínez; Domingo García Pérez de Lema; Salvador Marín Hernández

    2009-01-01

    El objetivo de este análisis consiste en identificar los obstáculos que enfrenta la pyme para la aprobación de un crédito bancario. Se realiza un estudio empírico con 128 empresas del sector manufacturero de Puebla, México. Los resultados, señalan a las tasas de interés como principal restricción a la hora de solicitar un crédito bancario, seguido del exceso de trámites o burocracia bancaria, el tercer lugar, lo ocupan las garantías. Las empresas maduras y medianas, son más proclives a la apr...

  5. Impacto de la innovación sobre el rendimiento de la mipyme: Un estudio empírico en Colombia

    Directory of Open Access Journals (Sweden)

    Edgar Julián Gálvez Albarracín, Ph.D

    2012-01-01

    Full Text Available El objetivo de este trabajo es verificar empíricamente la relación existente entre el grado de innovación de la empresa y su rendimiento, para lo cual se realiza un estudio con sesenta micro, pequeñas y medianas empresas (MIPYME de mediana y alta tecnología de la ciudad de Cali (Colombia. Los resultados muestran que la innovación en productos y en procesos ejerce una influencia positiva sobre el rendimiento de la MIPYME. Estos hallazgos refuerzan los postulados que muestran a la innovación como una ventaja competitiva sostenible, así mismo pueden ser de utilidad para los empresarios, al constatar la necesidad de innovar para mejorar su competitividad y para la administración pública en su papel de promotora de la innovación a través de programas de apoyo financiero y no financiero.

  6. Diferencias del clima laboral entre empleados contratados por outsourcing y empleados directos: evidencia empírica de la zona norte de Colombia.

    Directory of Open Access Journals (Sweden)

    David Juliao Esparragoza

    2014-12-01

    Full Text Available Son pocos los estudios empíricos sobre clima laboral en Colombia que muestran las diferencias entre grupos de trabajadores que, teniendo las mismas funciones en la empresa, cuentan con diferentes tipos de contrato. Esta investigación, a partir de un estudio realizado con empleados de una importante empresa de bebidas ubicada en la costa norte de Colombia, trata de aportar a la resolución de esta carencia, verificando si existen diferencias significativas, en algunas variables del clima laboral, entre los grupos de trabajadores contratados directamente y aquellos vinculados por prestación de servicios. El trabajo es de tipo descriptivo y transversal, se apoya en el método hipotético inductivo y utiliza el instrumento imcoc (evaluando las diferencias inter-grupales en las seis variables que lo componen, a saber: objetivos, cooperación, liderazgo, toma de decisiones, relaciones interpersonales, motivación y control.

  7. Pulsed ultrasonic stir welding system

    Science.gov (United States)

    Ding, R. Jeffrey (Inventor)

    2013-01-01

    An ultrasonic stir welding system includes a welding head assembly having a plate and a rod passing through the plate. The rod is rotatable about a longitudinal axis thereof. During a welding operation, ultrasonic pulses are applied to the rod as it rotates about its longitudinal axis. The ultrasonic pulses are applied in such a way that they propagate parallel to the longitudinal axis of the rod.

  8. Optical pulses, lasers, measuring techniques

    CERN Document Server

    Früngel, Frank B A

    1965-01-01

    High Speed Pulse Technology: Volume II: Optical Pulses - Lasers - Measuring Techniques focuses on the theoretical and engineering problems that result from the capacitor discharge technique.This book is organized into three main topics: light flash production from a capacitive energy storage; signal transmission and ranging systems by capacitor discharges and lasers; and impulse measuring technique. This text specifically discusses the air spark under atmospheric conditions, industrial equipment for laser flashing, and claims for light transmitting system. The application of light impulse sign

  9. Pulsed feedback defers cellular differentiation.

    Directory of Open Access Journals (Sweden)

    Joe H Levine

    2012-01-01

    Full Text Available Environmental signals induce diverse cellular differentiation programs. In certain systems, cells defer differentiation for extended time periods after the signal appears, proliferating through multiple rounds of cell division before committing to a new fate. How can cells set a deferral time much longer than the cell cycle? Here we study Bacillus subtilis cells that respond to sudden nutrient limitation with multiple rounds of growth and division before differentiating into spores. A well-characterized genetic circuit controls the concentration and phosphorylation of the master regulator Spo0A, which rises to a critical concentration to initiate sporulation. However, it remains unclear how this circuit enables cells to defer sporulation for multiple cell cycles. Using quantitative time-lapse fluorescence microscopy of Spo0A dynamics in individual cells, we observed pulses of Spo0A phosphorylation at a characteristic cell cycle phase. Pulse amplitudes grew systematically and cell-autonomously over multiple cell cycles leading up to sporulation. This pulse growth required a key positive feedback loop involving the sporulation kinases, without which the deferral of sporulation became ultrasensitive to kinase expression. Thus, deferral is controlled by a pulsed positive feedback loop in which kinase expression is activated by pulses of Spo0A phosphorylation. This pulsed positive feedback architecture provides a more robust mechanism for setting deferral times than constitutive kinase expression. Finally, using mathematical modeling, we show how pulsing and time delays together enable "polyphasic" positive feedback, in which different parts of a feedback loop are active at different times. Polyphasic feedback can enable more accurate tuning of long deferral times. Together, these results suggest that Bacillus subtilis uses a pulsed positive feedback loop to implement a "timer" that operates over timescales much longer than a cell cycle.

  10. Artistic Representation with Pulsed Holography

    Science.gov (United States)

    Ishii, S.

    2013-02-01

    This thesis describes artistic representation through pulsed holography. One of the prevalent practical problems in making holograms is object movement. Any movement of the object or film, including movement caused by acoustic vibration, has the same fatal results. One way of reducing the chance of movement is by ensuring that the exposure is very quick; using a pulsed laser can fulfill this objective. The attractiveness of using pulsed laser is based on the variety of materials or objects that can be recorded (e.g., liquid material or instantaneous scene of a moving object). One of the most interesting points about pulsed holograms is that some reconstructed images present us with completely different views of the real world. For example, the holographic image of liquid material does not appear fluid; it looks like a piece of hard glass that would produce a sharp sound upon tapping. In everyday life, we are unfamiliar with such an instantaneous scene. On the other hand, soft-textured materials such as a feather or wool differ from liquids when observed through holography. Using a pulsed hologram, we can sense the soft touch of the object or material with the help of realistic three-dimensional (3-D) images. The images allow us to realize the sense of touch in a way that resembles touching real objects. I had the opportunity to use a pulsed ruby laser soon after I started to work in the field of holography in 1979. Since then, I have made pulsed holograms of activities, including pouring water, breaking eggs, blowing soap bubbles, and scattering feathers and popcorn. I have also created holographic art with materials and objects, such as silk fiber, fabric, balloons, glass, flowers, and even the human body. Whenever I create art, I like to present the spectator with a new experience in perception. Therefore, I would like to introduce my experimental artwork through those pulsed holograms.

  11. Análisis de la Simplificación de Expresiones Numéricas en Español mediante un Estudio Empírico

    Directory of Open Access Journals (Sweden)

    Susana Bautista

    2012-12-01

    Full Text Available En este artículo se presentan los resultados de un estudio empírico llevado a cabo con un corpus paralelo de textos originales y simplificados a mano, y una posterior encuesta online, con el objetivo de identificar operaciones de simplificación de expresiones numéricas en español. Consideramos una "expresión numérica" como una frase que expresa una cantidad que puede venir acompañada de un modificador numérico, como por ejemplo casi un cuarto. Los resultados se analizan considerando las expresiones numéricas en oraciones con y sin contexto, a partir del análisis del corpus y del análisis de los resultados recogidos en la encuesta. Consideramos como trabajo futuro llevar a cabo una implementación computacional de las reglas de transformación extraídas.En este artículo se presentan los resultados de un estudio empírico llevado a cabo con un corpus paralelo de textos originales y simplificados a mano, y una posterior encuesta online, con el objetivo de identificar operaciones de simplificación de expresiones numéricas en español. Consideramos una "expresión numérica" como una frase que expresa una cantidad que puede venir acompañada de un modificador numérico, como por ejemplo casi un cuarto. Los resultados se analizan considerando las expresiones numéricas en oraciones con y sin contexto, a partir del análisis del corpus y del análisis de los resultados recogidos en la encuesta. Consideramos como trabajo futuro llevar a cabo una implementación computacional de las reglas de transformación extraídas.

  12. A polyphase metamorphic evolution for the Xitieshan paragneiss of the north Qaidam UHP metamorphic belt, western China: In-situ EMP monazite- and U-Pb zircon SHRIMP dating

    NARCIS (Netherlands)

    Zhang, C.; Roermund, H.L.M. van; Zhang, L.; Spiers, C.

    2012-01-01

    In-situ electron microprobe (EMP) U–Th–Pbmonazite-, sensitive high-resolution ion microprobe (SHRIMP) zircon analyses, metamorphic phase equilibrium (Domino/Theriak)- and geothermobarometric calculations are performed on kyanite/sillimanite-bearing garnet biotite gneisses forming part of the dominan

  13. Millijoule pulse energy picosecond fiber chirped-pulse amplification system

    Institute of Scientific and Technical Information of China (English)

    Zhi Yang; Xiaohong Hu; Yishan Wang; Wei Zhang; Wei Zhao

    2011-01-01

    @@ The efficient generation of a 1.17-mJ laser pul8e with 360 ps duration using an ytterbium (Yb)-doped fiber amplifier chain seeded by a homemade mode-locked fiber laser is demonstrated experimentally.A specially designed figure-of-eight fiber laser acts as the seed source of a chirped-pulse amplification (CPA) system and generates mode-locked pulse8 with hundreds of picosecond widths.Two kinds of large-mode-area (LMA) double-clad Yb-doped fibers are employed to construct the pre-amplifier and main amplifier, All of the adopted instruments help avoid severe nonlinearity in fibers to raise sub-nanosecond pulse energy with acceptable signal-to-noise ratio (SNR).The output spectrum of this fiber-based CPA system shows that amplified spontaneous emission (ASE) is suppressed to better than 30 dB, and the onset of stimulated Raman scattering is excluded.%The efficient generation of a 1.17-mJ laser pulse with 360 ps duration using an ytterbium (Yb)-doped fiber amplifier chain seeded by a homemade mode-locked fiber laser is demonstrated experimentally. A specially designed figure-of-eight fiber laser acts as the seed source of a chirped-pulse amplification (CPA) system and generates mode-locked pulses with hundreds of picosecond widths. Two kinds of large-mode-area (LMA) double-clad Yb-doped fibers are employed to construct the pre-amplifier and main amplifier. All of the adopted instruments help avoid severe nonlinearity in fibers to raise sub-nanosecond pulse energy with acceptable signal-to-noise ratio (SNR). The output spectrum of this fiber-based CPA system shows that amplified spontaneous emission (ASE) is suppressed to better than 30 dB, and the onset of stimulated Raman scattering is excluded.

  14. Arduino based radiation survey meter

    Energy Technology Data Exchange (ETDEWEB)

    Rahman, Nur Aira Abd, E-mail: nur-aira@nm.gov.my; Lombigit, Lojius; Abdullah, Nor Arymaswati; Azman, Azraf; Dolah, Taufik; Jaafar, Zainudin; Mohamad, Glam Hadzir Patai; Ramli, Abd Aziz Mhd; Zain, Rasif Mohd; Said, Fazila; Khalid, Mohd Ashhar; Taat, Muhamad Zahidee [Malaysian Nuclear Agency, 43000, Bangi, Selangor (Malaysia); Muzakkir, Amir [Sinaran Utama Teknologi Sdn Bhd, 43650, Bandar Baru Bangi, Selangor (Malaysia)

    2016-01-22

    This paper presents the design of new digital radiation survey meter with LND7121 Geiger Muller tube detector and Atmega328P microcontroller. Development of the survey meter prototype is carried out on Arduino Uno platform. 16-bit Timer1 on the microcontroller is utilized as external pulse counter to produce count per second or CPS measurement. Conversion from CPS to dose rate technique is also performed by Arduino to display results in micro Sievert per hour (μSvhr{sup −1}). Conversion factor (CF) value for conversion of CPM to μSvhr{sup −1} determined from manufacturer data sheet is compared with CF obtained from calibration procedure. The survey meter measurement results are found to be linear for dose rates below 3500 µSv/hr.

  15. Arduino based radiation survey meter

    Science.gov (United States)

    Rahman, Nur Aira Abd; Lombigit, Lojius; Abdullah, Nor Arymaswati; Azman, Azraf; Dolah, Taufik; Muzakkir, Amir; Jaafar, Zainudin; Mohamad, Glam Hadzir Patai; Ramli, Abd Aziz Mhd; Zain, Rasif Mohd; Said, Fazila; Khalid, Mohd Ashhar; Taat, Muhamad Zahidee

    2016-01-01

    This paper presents the design of new digital radiation survey meter with LND7121 Geiger Muller tube detector and Atmega328P microcontroller. Development of the survey meter prototype is carried out on Arduino Uno platform. 16-bit Timer1 on the microcontroller is utilized as external pulse counter to produce count per second or CPS measurement. Conversion from CPS to dose rate technique is also performed by Arduino to display results in micro Sievert per hour (μSvhr-1). Conversion factor (CF) value for conversion of CPM to μSvhr-1 determined from manufacturer data sheet is compared with CF obtained from calibration procedure. The survey meter measurement results are found to be linear for dose rates below 3500 µSv/hr.

  16. Square pulse linear transformer driver

    Directory of Open Access Journals (Sweden)

    A. A. Kim

    2012-04-01

    Full Text Available The linear transformer driver (LTD technological approach can result in relatively compact devices that can deliver fast, high current, and high-voltage pulses straight out of the LTD cavity without any complicated pulse forming and pulse compression network. Through multistage inductively insulated voltage adders, the output pulse, increased in voltage amplitude, can be applied directly to the load. The usual LTD architecture [A. A. Kim, M. G. Mazarakis, V. A. Sinebryukhov, B. M. Kovalchuk, V. A. Vizir, S. N Volkov, F. Bayol, A. N. Bastrikov, V. G. Durakov, S. V. Frolov, V. M. Alexeenko, D. H. McDaniel, W. E. Fowler, K. LeCheen, C. Olson, W. A. Stygar, K. W. Struve, J. Porter, and R. M. Gilgenbach, Phys. Rev. ST Accel. Beams 12, 050402 (2009PRABFM1098-440210.1103/PhysRevSTAB.12.050402; M. G. Mazarakis, W. E. Fowler, A. A. Kim, V. A. Sinebryukhov, S. T. Rogowski, R. A. Sharpe, D. H. McDaniel, C. L. Olson, J. L. Porter, K. W. Struve, W. A. Stygar, and J. R. Woodworth, Phys. Rev. ST Accel. Beams 12, 050401 (2009PRABFM1098-440210.1103/PhysRevSTAB.12.050401] provides sine shaped output pulses that may not be well suited for some applications like z-pinch drivers, flash radiography, high power microwaves, etc. A more suitable power pulse would have a flat or trapezoidal (rising or falling top. In this paper, we present the design and first test results of an LTD cavity that generates such a type of output pulse by including within its circular array a number of third harmonic bricks in addition to the main bricks. A voltage adder made out of a square pulse cavity linear array will produce the same shape output pulses provided that the timing of each cavity is synchronized with the propagation of the electromagnetic pulse.

  17. High-Altitude Electromagnetic Pulse (HEMP) Testing

    Science.gov (United States)

    2015-07-09

    Electromagnetic Pulse Horizontal Electromagnetic Pulse Advanced Fast Electromagnetic Pulse Nuclear Weapons Effect Testing and Environments 16. SECURITY...TOP 01-2-620A 9 July 2015 G-1 APPENDIX G. ABBREVIATIONS. AFEMP Advanced Fast Electromagnetic ... Electromagnetic Pulse A burst of electromagnetic radiation from a nuclear explosion or a suddenly fluctuating magnetic field. The resulting electric and

  18. X-Ray Scattering Applications Using Pulsed X-Ray Sources

    Energy Technology Data Exchange (ETDEWEB)

    Larson, B.C.

    1999-05-23

    Pulsed x-ray sources have been used in transient structural phenomena investigations for over fifty years; however, until the advent of synchrotrons sources and the development of table-top picosecond lasers, general access to ligh temporal resolution x-ray diffraction was relatively limited. Advances in diffraction techniques, sample excitation schemes, and detector systems, in addition to IncEased access to pulsed sources, have ld tO what is now a diverse and growing array of pulsed-source measurement applications. A survey of time-resolved investigations using pulsed x-ray sources is presented and research opportunities using both present and planned pulsed x-ray sources are discussed.

  19. Laser ranging by time-of-flight measurement of femtosecond light pulses

    Science.gov (United States)

    Kim, Young-Jin

    2014-04-01

    Time-of-flight (TOF) measurement of femtosecond light pulses was investigated for laser ranging of long distances with sub-micrometer precision in the air. The bandwidth limitation of the photo-detection electronics used in timing femtosecond pulses was overcome by adopting a type-II nonlinear second-harmonic crystal that permits producing the balanced optical cross-correlation signal between two overlapped light pulses. This method offered a sub-femtosecond timing resolution in determining the temporal offset between two pulses through lock-in control of the pulse repetition rate with reference to the atomic clock. The exceptional ranging capability was verified by measuring various distances from 1.5 m to 700 m. This method is found suited for terrestrial land surveying and space missions of formation-flying satellites.

  20. High precision laser ranging by time-of-flight measurement of femtosecond pulses

    Science.gov (United States)

    Lee, Joohyung; Lee, Keunwoo; Lee, Sanghyun; Kim, Seung-Woo; Kim, Young-Jin

    2012-06-01

    Time-of-flight (TOF) measurement of femtosecond light pulses was investigated for laser ranging of long distances with sub-micrometer precision in the air. The bandwidth limitation of the photo-detection electronics used in timing femtosecond pulses was overcome by adopting a type-II nonlinear second-harmonic crystal that permits the production of a balanced optical cross-correlation signal between two overlapping light pulses. This method offered a sub-femtosecond timing resolution in determining the temporal offset between two pulses through lock-in control of the pulse repetition rate with reference to the atomic clock. The exceptional ranging capability was verified by measuring various distances of 1.5, 60 and 700 m. This method is found well suited for future space missions based on formation-flying satellites as well as large-scale industrial applications for land surveying, aircraft manufacturing and shipbuilding.